<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE106312" accession="SRP122899">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP122899</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA416270</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE106312</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Genome-wide RNA-seq from c-MYC-depleted and rescued MDA-MB-231BrM cells</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>Purpose: To identify downstream signaling pathways that mediate functions of c-MYC Methods: RNAs isolated from MDA231-BrM cells expressing shCntr or shc-MYC,  pCDH-puro control vector or c-MYC expression vector were analyzed by using an Illumina Nextseq500 Conclusions: Our study represents the first transcriptome profile of c-MYC-depleted and rescured MDA231-BrM Overall design: mRNAs prepared from c-MYC knockdown or c-MYC rescued  MDA-MB-231 BrM cells were analyzed in duplicaters by Illumina Nextseq500. RNA-Seq reads were aligned to the human reference genome (NCBI 38) using the spliced read aligner STAR software (ver2.5)</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE106312</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
  </STUDY>
</STUDY_SET>
