<?xml version="1.0" encoding="UTF-8"?>
<EXPERIMENT_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <EXPERIMENT accession="SRX3401320" alias="343_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 3_HTS44_124.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401320</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">343_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 3_HTS44_124.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695458">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695458</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">343_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 3_HTS44_124.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>343_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 3_HTS44_124.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401321" alias="345_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 3_HTS44_126.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401321</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">345_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 3_HTS44_126.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695459">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695459</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">345_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 3_HTS44_126.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>345_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 3_HTS44_126.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401322" alias="382_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 3_HTS44_139.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401322</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">382_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 3_HTS44_139.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695460">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695460</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">382_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 3_HTS44_139.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>382_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 3_HTS44_139.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401323" alias="380_BthBth fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 2_HTS44_119.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401323</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">380_BthBth fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 2_HTS44_119.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695461">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695461</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">380_BthBth fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 2_HTS44_119.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>380_BthBth fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 2_HTS44_119.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401324" alias="384_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 3_HTS44_141.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401324</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">384_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 3_HTS44_141.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695462">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695462</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">384_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 3_HTS44_141.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>384_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 3_HTS44_141.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401325" alias="383_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 3_HTS44_140.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401325</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">383_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 3_HTS44_140.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695463">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695463</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">383_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 3_HTS44_140.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>383_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 3_HTS44_140.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401326" alias="387_BthBth fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 3_HTS44_144.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401326</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">387_BthBth fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 3_HTS44_144.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695464">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695464</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">387_BthBth fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 3_HTS44_144.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>387_BthBth fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 3_HTS44_144.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401327" alias="378_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 2_HTS44_117.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401327</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">378_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 2_HTS44_117.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695465">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695465</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">378_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 2_HTS44_117.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>378_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 2_HTS44_117.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401328" alias="334_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 2_HTS44_103.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401328</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">334_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 2_HTS44_103.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695466">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695466</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">334_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 2_HTS44_103.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>334_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 2_HTS44_103.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401329" alias="335_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 2_HTS44_104.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401329</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">335_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 2_HTS44_104.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695467">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695467</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">335_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 2_HTS44_104.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>335_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 2_HTS44_104.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401330" alias="336_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 2_HTS44_105.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401330</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">336_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 2_HTS44_105.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695468">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695468</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">336_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 2_HTS44_105.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>336_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 2_HTS44_105.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401331" alias="337_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 2_HTS44_106.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401331</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">337_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 2_HTS44_106.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695469">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695469</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">337_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 2_HTS44_106.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>337_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 2_HTS44_106.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401332" alias="339_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS44_108.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401332</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">339_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS44_108.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695470">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695470</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">339_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS44_108.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>339_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS44_108.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401333" alias="340_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 3_HTS44_121.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401333</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">340_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 3_HTS44_121.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695471">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695471</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">340_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 3_HTS44_121.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>340_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 3_HTS44_121.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401334" alias="341_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 3_HTS44_122.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401334</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">341_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 3_HTS44_122.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695472">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695472</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">341_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 3_HTS44_122.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>341_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 3_HTS44_122.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401335" alias="342_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 3_HTS44_123.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401335</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">342_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 3_HTS44_123.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695473">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695473</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">342_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 3_HTS44_123.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>342_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 3_HTS44_123.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401336" alias="193_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 3_HTS44_136.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401336</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">193_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 3_HTS44_136.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695474">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695474</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">193_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 3_HTS44_136.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>193_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 3_HTS44_136.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401337" alias="192_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 3_HTS44_135.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401337</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">192_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 3_HTS44_135.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695475">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695475</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">192_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 3_HTS44_135.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>192_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 3_HTS44_135.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401338" alias="245_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 3_HTS40_26.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401338</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">245_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 3_HTS40_26.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695476">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695476</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">245_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 3_HTS40_26.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>245_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 3_HTS40_26.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401339" alias="185_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 2_HTS44_111.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401339</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">185_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 2_HTS44_111.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695477">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695477</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">185_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 2_HTS44_111.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>185_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 2_HTS44_111.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401340" alias="184_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 2_HTS44_110.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401340</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">184_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 2_HTS44_110.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695478">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695478</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">184_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 2_HTS44_110.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>184_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 2_HTS44_110.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401341" alias="187_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 2_HTS44_113.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401341</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">187_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 2_HTS44_113.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695479">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695479</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">187_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 2_HTS44_113.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>187_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 2_HTS44_113.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401342" alias="186_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 2_HTS44_112.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401342</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">186_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 2_HTS44_112.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695480">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695480</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">186_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 2_HTS44_112.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>186_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 2_HTS44_112.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401343" alias="189_Bthbth fibroblast-no treatment-replicate 3_HTS44_132.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401343</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">189_Bthbth fibroblast-no treatment-replicate 3_HTS44_132.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695481">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695481</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">189_Bthbth fibroblast-no treatment-replicate 3_HTS44_132.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>189_Bthbth fibroblast-no treatment-replicate 3_HTS44_132.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401344" alias="188_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 2_HTS44_114.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401344</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">188_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 2_HTS44_114.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695482">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695482</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">188_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 2_HTS44_114.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>188_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 2_HTS44_114.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401345" alias="191_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 3_HTS44_134.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401345</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">191_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 3_HTS44_134.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695483">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695483</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">191_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 3_HTS44_134.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>191_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 3_HTS44_134.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401346" alias="190_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 3_HTS44_133.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401346</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">190_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 3_HTS44_133.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695484">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695484</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">190_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 3_HTS44_133.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>190_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 3_HTS44_133.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401347" alias="248_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 4_HTS40_35.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401347</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">248_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 4_HTS40_35.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695485">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695485</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">248_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 4_HTS40_35.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>248_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 4_HTS40_35.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401348" alias="217_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 2_HTS40_46.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401348</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">217_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 2_HTS40_46.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695486">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695486</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">217_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 2_HTS40_46.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>217_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 2_HTS40_46.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401349" alias="385_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 3_HTS44_142.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401349</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">385_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 3_HTS44_142.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695487">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695487</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">385_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 3_HTS44_142.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>385_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 3_HTS44_142.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401350" alias="241_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 3_HTS40_22.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401350</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">241_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 3_HTS40_22.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695516">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695516</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">241_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 3_HTS40_22.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>241_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 3_HTS40_22.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401351" alias="289_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 1_HTS44_10.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401351</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">289_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 1_HTS44_10.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695488">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695488</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">289_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 1_HTS44_10.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>289_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 1_HTS44_10.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401352" alias="288_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 1_HTS44_9.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401352</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">288_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 1_HTS44_9.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695489">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695489</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">288_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 1_HTS44_9.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>288_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 1_HTS44_9.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401353" alias="291_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 1_HTS44_12.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401353</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">291_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 1_HTS44_12.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695490">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695490</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">291_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 1_HTS44_12.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>291_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 1_HTS44_12.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401354" alias="290_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 1_HTS44_11.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401354</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">290_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 1_HTS44_11.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695491">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695491</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">290_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 1_HTS44_11.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>290_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 1_HTS44_11.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401355" alias="285_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 1_HTS44_6.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401355</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">285_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 1_HTS44_6.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695492">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695492</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">285_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 1_HTS44_6.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>285_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 1_HTS44_6.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401356" alias="284_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 1_HTS44_5.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401356</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">284_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 1_HTS44_5.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695493">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695493</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">284_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 1_HTS44_5.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>284_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 1_HTS44_5.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401357" alias="287_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 1_HTS44_8.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401357</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">287_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 1_HTS44_8.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695494">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695494</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">287_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 1_HTS44_8.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>287_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 1_HTS44_8.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401358" alias="286_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 1_HTS44_7.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401358</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">286_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 1_HTS44_7.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695496">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695496</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">286_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 1_HTS44_7.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>286_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 1_HTS44_7.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401359" alias="251_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 4_HTS40_38.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401359</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">251_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 4_HTS40_38.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695495">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695495</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">251_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 4_HTS40_38.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>251_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 4_HTS40_38.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401360" alias="293_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 2_HTS44_26.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401360</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">293_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 2_HTS44_26.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695498">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695498</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">293_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 2_HTS44_26.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>293_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 2_HTS44_26.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401361" alias="292_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 2_HTS44_25.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401361</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">292_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 2_HTS44_25.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695497">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695497</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">292_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 2_HTS44_25.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>292_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 2_HTS44_25.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401362" alias="354_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 1_HTS44_21.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401362</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">354_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 1_HTS44_21.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695499">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695499</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">354_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 1_HTS44_21.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>354_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 1_HTS44_21.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401363" alias="353_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 1_HTS44_20.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401363</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">353_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 1_HTS44_20.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695500">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695500</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">353_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 1_HTS44_20.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>353_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 1_HTS44_20.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401364" alias="352_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 1_HTS44_19.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401364</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">352_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 1_HTS44_19.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695501">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695501</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">352_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 1_HTS44_19.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>352_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 1_HTS44_19.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401365" alias="351_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS44_132.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401365</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">351_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS44_132.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695502">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695502</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">351_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS44_132.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>351_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS44_132.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401366" alias="350_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 3_HTS44_131.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401366</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">350_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 3_HTS44_131.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695503">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695503</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">350_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 3_HTS44_131.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>350_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 3_HTS44_131.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401367" alias="348_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 3_HTS44_129.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401367</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">348_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 3_HTS44_129.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695504">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695504</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">348_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 3_HTS44_129.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>348_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 3_HTS44_129.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401368" alias="347_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 3_HTS44_128.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401368</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">347_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 3_HTS44_128.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695505">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695505</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">347_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 3_HTS44_128.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>347_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 3_HTS44_128.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401369" alias="346_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 3_HTS44_127.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401369</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">346_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 3_HTS44_127.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695506">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695506</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">346_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 3_HTS44_127.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>346_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 3_HTS44_127.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401370" alias="219_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 2_HTS40_48.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401370</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">219_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 2_HTS40_48.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695507">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695507</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">219_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 2_HTS40_48.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>219_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 2_HTS40_48.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401371" alias="218_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 2_HTS40_47.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401371</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">218_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 2_HTS40_47.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695508">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695508</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">218_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 2_HTS40_47.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>218_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 2_HTS40_47.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401372" alias="356_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 1_HTS44_23.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401372</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">356_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 1_HTS44_23.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695509">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695509</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">356_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 1_HTS44_23.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>356_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 1_HTS44_23.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401373" alias="355_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 1_HTS44_22.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401373</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">355_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 1_HTS44_22.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695510">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695510</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">355_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 1_HTS44_22.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>355_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 1_HTS44_22.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401374" alias="182_Bthbth fibroblast-no treatment-replicate 2_HTS44_108.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401374</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">182_Bthbth fibroblast-no treatment-replicate 2_HTS44_108.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695511">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695511</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">182_Bthbth fibroblast-no treatment-replicate 2_HTS44_108.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>182_Bthbth fibroblast-no treatment-replicate 2_HTS44_108.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401375" alias="183_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 2_HTS44_109.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401375</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">183_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 2_HTS44_109.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695512">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695512</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">183_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 2_HTS44_109.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>183_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 2_HTS44_109.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401376" alias="176_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 1_HTS44_85.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401376</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">176_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 1_HTS44_85.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695513">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695513</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">176_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 1_HTS44_85.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>176_Bthbth fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 1_HTS44_85.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401377" alias="177_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 1_HTS44_86.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401377</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">177_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 1_HTS44_86.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695514">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695514</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">177_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 1_HTS44_86.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>177_Bthbth fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 1_HTS44_86.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401378" alias="174_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 3_HTS44_66.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401378</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">174_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 3_HTS44_66.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695515">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695515</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">174_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 3_HTS44_66.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>174_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 3_HTS44_66.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401379" alias="175_Bthbth fibroblast-no treatment-replicate 1_HTS44_84.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401379</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">175_Bthbth fibroblast-no treatment-replicate 1_HTS44_84.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695517">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695517</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">175_Bthbth fibroblast-no treatment-replicate 1_HTS44_84.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>175_Bthbth fibroblast-no treatment-replicate 1_HTS44_84.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401380" alias="180_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 1_HTS44_89.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401380</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">180_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 1_HTS44_89.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695518">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695518</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">180_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 1_HTS44_89.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>180_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 1_HTS44_89.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401381" alias="181_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 1_HTS44_90.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401381</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">181_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 1_HTS44_90.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695519">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695519</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">181_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 1_HTS44_90.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>181_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 1_HTS44_90.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401382" alias="178_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 1_HTS44_87.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401382</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">178_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 1_HTS44_87.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695520">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695520</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">178_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 1_HTS44_87.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>178_Bthbth fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 1_HTS44_87.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401383" alias="179_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 1_HTS44_88.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401383</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">179_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 1_HTS44_88.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695521">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695521</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">179_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 1_HTS44_88.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>179_Bthbth fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 1_HTS44_88.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401384" alias="246_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 3_HTS40_27.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401384</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">246_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 3_HTS40_27.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695522">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695522</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">246_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 3_HTS40_27.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>246_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 3_HTS40_27.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401385" alias="214_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 2_HTS40_43.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401385</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">214_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 2_HTS40_43.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695523">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695523</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">214_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 2_HTS40_43.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>214_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 2_HTS40_43.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401386" alias="215_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 2_HTS40_44.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401386</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">215_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 2_HTS40_44.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695524">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695524</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">215_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 2_HTS40_44.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>215_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 2_HTS40_44.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401387" alias="212_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 4_HTS40_33.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401387</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">212_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 4_HTS40_33.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695525">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695525</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">212_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 4_HTS40_33.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>212_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 4_HTS40_33.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401388" alias="254_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 4_HTS40_41.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401388</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">254_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 4_HTS40_41.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695526">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695526</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">254_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 4_HTS40_41.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>254_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 4_HTS40_41.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401389" alias="255_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 4_HTS40_42.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401389</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">255_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 4_HTS40_42.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695527">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695527</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">255_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 4_HTS40_42.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>255_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 4_HTS40_42.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401390" alias="256_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 2_HTS40_49.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401390</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">256_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 2_HTS40_49.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695528">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695528</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">256_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 2_HTS40_49.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>256_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 2_HTS40_49.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401391" alias="257_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 2_HTS40_50.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401391</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">257_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 2_HTS40_50.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695529">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695529</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">257_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 2_HTS40_50.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>257_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 2_HTS40_50.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401392" alias="258_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 2_HTS40_51.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401392</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">258_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 2_HTS40_51.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695531">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695531</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">258_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 2_HTS40_51.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>258_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 2_HTS40_51.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401393" alias="259_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 2_HTS40_52.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401393</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">259_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 2_HTS40_52.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695530">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695530</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">259_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 2_HTS40_52.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>259_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 2_HTS40_52.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401394" alias="260_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 2_HTS40_53.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401394</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">260_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 2_HTS40_53.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695533">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695533</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">260_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 2_HTS40_53.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>260_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 2_HTS40_53.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401395" alias="261_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 2_HTS40_54.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401395</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">261_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 2_HTS40_54.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695532">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695532</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">261_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 2_HTS40_54.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>261_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 2_HTS40_54.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401396" alias="262_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 2_HTS40_55.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401396</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">262_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 2_HTS40_55.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695534">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695534</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">262_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 2_HTS40_55.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>262_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 2_HTS40_55.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401397" alias="263_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS10_56.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401397</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">263_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS10_56.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695535">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695535</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">263_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS10_56.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>263_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS10_56.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401398" alias="171_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 3_HTS44_63.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401398</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">171_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 3_HTS44_63.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695536">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695536</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">171_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 3_HTS44_63.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>171_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 3_HTS44_63.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401399" alias="170_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 3_HTS44_62.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401399</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">170_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 3_HTS44_62.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695537">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695537</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">170_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 3_HTS44_62.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>170_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 3_HTS44_62.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401400" alias="169_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 3_HTS44_61.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401400</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">169_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 3_HTS44_61.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695538">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695538</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">169_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 3_HTS44_61.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>169_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 3_HTS44_61.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401401" alias="168_WT fibroblast-no treatment-replicate 3_HTS44_60.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401401</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">168_WT fibroblast-no treatment-replicate 3_HTS44_60.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695539">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695539</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">168_WT fibroblast-no treatment-replicate 3_HTS44_60.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>168_WT fibroblast-no treatment-replicate 3_HTS44_60.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401402" alias="167_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 2_HTS44_42.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401402</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">167_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 2_HTS44_42.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695540">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695540</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">167_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 2_HTS44_42.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>167_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 2_HTS44_42.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401403" alias="166_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 2_HTS44_41.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401403</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">166_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 2_HTS44_41.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695541">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695541</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">166_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 2_HTS44_41.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>166_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 2_HTS44_41.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401404" alias="165_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 2_HTS44_40.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401404</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">165_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 2_HTS44_40.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695542">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695542</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">165_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 2_HTS44_40.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>165_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 2_HTS44_40.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401405" alias="164_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 2_HTS44_39.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401405</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">164_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 2_HTS44_39.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695543">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695543</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">164_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 2_HTS44_39.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>164_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 2_HTS44_39.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401406" alias="244_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 3_HTS40_25.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401406</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">244_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 3_HTS40_25.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695544">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695544</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">244_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 3_HTS40_25.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>244_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 3_HTS40_25.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401407" alias="173_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 3_HTS44_65.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401407</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">173_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 3_HTS44_65.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695545">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695545</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">173_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 3_HTS44_65.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>173_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 3_HTS44_65.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401408" alias="172_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 3_HTS44_64.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401408</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">172_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 3_HTS44_64.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695546">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695546</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">172_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 3_HTS44_64.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>172_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 3_HTS44_64.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401409" alias="273_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 4_HTS40_78.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401409</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">273_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 4_HTS40_78.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695547">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695547</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">273_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 4_HTS40_78.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>273_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 4_HTS40_78.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401410" alias="272_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 4_HTS40_77.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401410</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">272_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 4_HTS40_77.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695548">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695548</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">272_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 4_HTS40_77.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>272_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 4_HTS40_77.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401411" alias="271_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS10_70.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401411</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">271_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS10_70.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695591">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695591</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">271_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS10_70.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>271_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS10_70.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401412" alias="270_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 3_HTS40_69.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401412</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">270_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 3_HTS40_69.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695549">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695549</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">270_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 3_HTS40_69.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>270_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 3_HTS40_69.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401413" alias="269_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 3_HTS40_68.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401413</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">269_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 3_HTS40_68.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695550">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695550</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">269_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 3_HTS40_68.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>269_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 3_HTS40_68.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401414" alias="268_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 3_HTS40_67.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401414</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">268_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 3_HTS40_67.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695551">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695551</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">268_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 3_HTS40_67.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>268_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 3_HTS40_67.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401415" alias="267_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 3_HTS40_66.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401415</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">267_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 3_HTS40_66.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695552">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695552</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">267_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 3_HTS40_66.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>267_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 3_HTS40_66.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401416" alias="266_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 3_HTS40_65.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401416</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">266_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 3_HTS40_65.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695553">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695553</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">266_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 3_HTS40_65.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>266_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 3_HTS40_65.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401417" alias="265_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 3_HTS40_64.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401417</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">265_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 3_HTS40_64.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695554">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695554</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">265_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 3_HTS40_64.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>265_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 3_HTS40_64.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401418" alias="264_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 3_HTS40_63.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401418</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">264_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 3_HTS40_63.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695555">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695555</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">264_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 3_HTS40_63.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>264_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 3_HTS40_63.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401419" alias="376_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 2_HTS44_115.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401419</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">376_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 2_HTS44_115.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695556">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695556</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">376_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 2_HTS44_115.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>376_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 2_HTS44_115.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401420" alias="377_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 2_HTS44_116.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401420</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">377_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 2_HTS44_116.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695557">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695557</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">377_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 2_HTS44_116.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>377_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 2_HTS44_116.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401421" alias="371_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 1_HTS44_92.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401421</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">371_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 1_HTS44_92.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695558">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695558</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">371_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 1_HTS44_92.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>371_BthBth fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 1_HTS44_92.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401422" alias="372_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 1_HTS44_93.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401422</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">372_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 1_HTS44_93.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695559">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695559</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">372_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 1_HTS44_93.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>372_BthBth fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 1_HTS44_93.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401423" alias="373_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 1_HTS44_94.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401423</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">373_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 1_HTS44_94.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695560">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695560</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">373_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 1_HTS44_94.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>373_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 1_HTS44_94.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401424" alias="374_BthBth fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 1_HTS44_95.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401424</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">374_BthBth fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 1_HTS44_95.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695561">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695561</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">374_BthBth fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 1_HTS44_95.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>374_BthBth fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 1_HTS44_95.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401425" alias="367_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 3_HTS44_70.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401425</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">367_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 3_HTS44_70.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695562">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695562</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">367_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 3_HTS44_70.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>367_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 3_HTS44_70.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401426" alias="368_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 3_HTS44_71.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401426</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">368_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 3_HTS44_71.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695563">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695563</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">368_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 3_HTS44_71.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>368_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 3_HTS44_71.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401427" alias="369_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 3_HTS44_72.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401427</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">369_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 3_HTS44_72.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695564">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695564</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">369_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 3_HTS44_72.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>369_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 3_HTS44_72.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401428" alias="370_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 1_HTS44_91.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401428</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">370_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 1_HTS44_91.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695565">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695565</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">370_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 1_HTS44_91.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>370_BthBth fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 1_HTS44_91.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401429" alias="229_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 4_HTS40_74.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401429</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">229_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 4_HTS40_74.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695566">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695566</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">229_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 4_HTS40_74.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>229_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 4_HTS40_74.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401430" alias="388-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS41-60.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401430</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">388-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS41-60.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695567">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695567</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">388-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS41-60.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>388-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS41-60.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401431" alias="228_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 4_HTS40_73.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401431</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">228_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 4_HTS40_73.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695568">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695568</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">228_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 4_HTS40_73.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>228_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 4_HTS40_73.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401432" alias="239_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS40_14.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401432</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">239_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS40_14.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695569">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695569</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">239_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS40_14.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>239_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS40_14.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401433" alias="230_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 4_HTS40_75.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401433</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">230_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 4_HTS40_75.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695570">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695570</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">230_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 4_HTS40_75.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>230_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 4_HTS40_75.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401434" alias="216_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 2_HTS40_45.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401434</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">216_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 2_HTS40_45.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695571">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695571</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">216_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 2_HTS40_45.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>216_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 2_HTS40_45.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401435" alias="243_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 3_HTS40_24.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401435</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">243_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 3_HTS40_24.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695572">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695572</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">243_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 3_HTS40_24.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>243_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 3_HTS40_24.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401436" alias="322_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 1_HTS44_79.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401436</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">322_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 1_HTS44_79.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695573">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695573</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">322_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 1_HTS44_79.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>322_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 1_HTS44_79.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401437" alias="323_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 1_HTS44_80.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401437</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">323_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 1_HTS44_80.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695574">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695574</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">323_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 1_HTS44_80.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>323_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 1_HTS44_80.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401438" alias="316_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 1_HTS44_73.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401438</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">316_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 1_HTS44_73.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695575">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695575</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">316_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 1_HTS44_73.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>316_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 1_HTS44_73.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401439" alias="317_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 1_HTS44_74.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401439</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">317_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 1_HTS44_74.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695576">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695576</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">317_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 1_HTS44_74.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>317_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 1_HTS44_74.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401440" alias="314_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 3_HTS44_59.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401440</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">314_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 3_HTS44_59.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695577">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695577</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">314_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 3_HTS44_59.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>314_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 3_HTS44_59.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401441" alias="315_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS44_60.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401441</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">315_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS44_60.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695578">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695578</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">315_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS44_60.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>315_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS44_60.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401442" alias="320_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 1_HTS44_77.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401442</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">320_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 1_HTS44_77.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695579">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695579</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">320_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 1_HTS44_77.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>320_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 1_HTS44_77.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401443" alias="321_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 1_HTS44_78.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401443</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">321_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 1_HTS44_78.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695580">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695580</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">321_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 1_HTS44_78.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>321_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 1_HTS44_78.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401444" alias="318_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 1_HTS44_75.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401444</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">318_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 1_HTS44_75.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695581">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695581</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">318_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 1_HTS44_75.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>318_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 1_HTS44_75.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401445" alias="319_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 1_HTS44_76.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401445</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">319_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 1_HTS44_76.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695582">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695582</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">319_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 1_HTS44_76.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>319_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 1_HTS44_76.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401446" alias="247_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS40_28.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401446</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">247_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS40_28.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695583">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695583</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">247_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS40_28.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>247_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 3_HTS40_28.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401447" alias="366_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 3_HTS44_69.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401447</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">366_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 3_HTS44_69.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695584">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695584</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">366_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 3_HTS44_69.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>366_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 3_HTS44_69.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401448" alias="365_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 3_HTS44_68.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401448</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">365_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 3_HTS44_68.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695585">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695585</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">365_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 3_HTS44_68.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>365_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 3_HTS44_68.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401449" alias="360_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 2_HTS44_45.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401449</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">360_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 2_HTS44_45.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695586">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695586</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">360_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 2_HTS44_45.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>360_WT fibroblast-SaCas9KKH-Tmc1-7-50 nM-Tmc1-replicate 2_HTS44_45.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401450" alias="359_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 2_HTS44_44.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401450</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">359_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 2_HTS44_44.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695587">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695587</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">359_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 2_HTS44_44.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>359_WT fibroblast-SaCas9KKH-Tmc1-7-25 nM-Tmc1-replicate 2_HTS44_44.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401451" alias="358_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 2_HTS44_43.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401451</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">358_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 2_HTS44_43.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695588">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695588</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">358_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 2_HTS44_43.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>358_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 2_HTS44_43.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401452" alias="357_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 1_HTS44_24.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401452</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">357_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 1_HTS44_24.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695589">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695589</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">357_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 1_HTS44_24.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>357_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 1_HTS44_24.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401453" alias="364_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 3_HTS44_67.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401453</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">364_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 3_HTS44_67.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695590">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695590</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">364_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 3_HTS44_67.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>364_WT fibroblast-SaCas9KKH-Tmc1-7-12.5 nM-Tmc1-replicate 3_HTS44_67.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401454" alias="363_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 2_HTS44_48.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401454</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">363_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 2_HTS44_48.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695625">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695625</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">363_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 2_HTS44_48.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>363_WT fibroblast-SaCas9KKH-Tmc1-7-400 nM-Tmc1-replicate 2_HTS44_48.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401455" alias="362_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 2_HTS44_47.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401455</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">362_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 2_HTS44_47.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695592">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695592</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">362_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 2_HTS44_47.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>362_WT fibroblast-SaCas9KKH-Tmc1-7-200 nM-Tmc1-replicate 2_HTS44_47.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401456" alias="361_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 2_HTS44_46.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401456</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">361_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 2_HTS44_46.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695593">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695593</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">361_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 2_HTS44_46.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>361_WT fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 2_HTS44_46.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401457" alias="157_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 1_HTS44_15.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401457</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">157_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 1_HTS44_15.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695595">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695595</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">157_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 1_HTS44_15.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>157_WT fibroblast-Cas9-Tmc1-mut3-50 nM-Tmc1-replicate 1_HTS44_15.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401458" alias="156_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 1_HTS44_14.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401458</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">156_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 1_HTS44_14.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695594">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695594</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">156_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 1_HTS44_14.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>156_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 1_HTS44_14.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401459" alias="155_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 1_HTS44_13.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401459</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">155_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 1_HTS44_13.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695596">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695596</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">155_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 1_HTS44_13.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>155_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 1_HTS44_13.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401460" alias="154_WT fibroblast-no treatment-replicate 1_HTS44_12.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401460</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">154_WT fibroblast-no treatment-replicate 1_HTS44_12.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695597">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695597</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">154_WT fibroblast-no treatment-replicate 1_HTS44_12.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>154_WT fibroblast-no treatment-replicate 1_HTS44_12.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401461" alias="161_WT fibroblast-no treatment-replicate 2_HTS44_36.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401461</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">161_WT fibroblast-no treatment-replicate 2_HTS44_36.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695598">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695598</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">161_WT fibroblast-no treatment-replicate 2_HTS44_36.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>161_WT fibroblast-no treatment-replicate 2_HTS44_36.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401462" alias="160_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 1_HTS44_18.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401462</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">160_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 1_HTS44_18.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695599">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695599</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">160_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 1_HTS44_18.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>160_WT fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 1_HTS44_18.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401463" alias="159_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 1_HTS44_17.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401463</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">159_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 1_HTS44_17.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695600">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695600</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">159_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 1_HTS44_17.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>159_WT fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 1_HTS44_17.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401464" alias="158_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 1_HTS44_16.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401464</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">158_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 1_HTS44_16.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695601">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695601</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">158_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 1_HTS44_16.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>158_WT fibroblast-Cas9-Tmc1-mut3-100 nM-Tmc1-replicate 1_HTS44_16.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401465" alias="233_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 2_HTS40_8.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401465</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">233_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 2_HTS40_8.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695602">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695602</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">233_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 2_HTS40_8.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>233_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 2_HTS40_8.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401466" alias="163_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 2_HTS44_38.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401466</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">163_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 2_HTS44_38.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695603">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695603</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">163_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 2_HTS44_38.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>163_WT fibroblast-Cas9-Tmc1-mut3-25 nM-Tmc1-replicate 2_HTS44_38.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401467" alias="162_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 2_HTS44_37.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401467</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">162_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 2_HTS44_37.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695604">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695604</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">162_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 2_HTS44_37.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>162_WT fibroblast-Cas9-Tmc1-mut3-12.5 nM-Tmc1-replicate 2_HTS44_37.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401468" alias="253_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 4_HTS40_40.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401468</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">253_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 4_HTS40_40.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695605">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695605</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">253_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 4_HTS40_40.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>253_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 4_HTS40_40.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401469" alias="232_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 2_HTS40_7.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401469</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">232_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 2_HTS40_7.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695606">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695606</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">232_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 2_HTS40_7.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>232_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 2_HTS40_7.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401470" alias="333_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 2_HTS44_102.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401470</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">333_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 2_HTS44_102.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695607">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695607</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">333_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 2_HTS44_102.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>333_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 2_HTS44_102.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401471" alias="332_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 2_HTS44_101.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401471</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">332_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 2_HTS44_101.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695608">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695608</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">332_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 2_HTS44_101.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>332_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 2_HTS44_101.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401472" alias="231_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 4_HTS40_76.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401472</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">231_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 4_HTS40_76.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695609">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695609</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">231_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 4_HTS40_76.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>231_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 4_HTS40_76.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401473" alias="207_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 3_HTS40_20.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401473</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">207_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 3_HTS40_20.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695642">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695642</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">207_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 3_HTS40_20.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>207_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 3_HTS40_20.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401474" alias="225_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 3_HTS40_62.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401474</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">225_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 3_HTS40_62.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695610">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695610</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">225_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 3_HTS40_62.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>225_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 3_HTS40_62.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401475" alias="224_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 3_HTS40_61.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401475</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">224_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 3_HTS40_61.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695611">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695611</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">224_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 3_HTS40_61.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>224_BthBth fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 3_HTS40_61.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401476" alias="227_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 4_HTS40_72.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401476</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">227_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 4_HTS40_72.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695612">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695612</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">227_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 4_HTS40_72.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>227_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 4_HTS40_72.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401477" alias="226_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 4_HTS40_71.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401477</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">226_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 4_HTS40_71.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695613">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695613</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">226_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 4_HTS40_71.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>226_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 4_HTS40_71.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401478" alias="325_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 1_HTS44_82.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401478</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">325_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 1_HTS44_82.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695614">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695614</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">325_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 1_HTS44_82.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>325_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 1_HTS44_82.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401479" alias="324_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 1_HTS44_81.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401479</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">324_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 1_HTS44_81.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695615">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695615</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">324_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 1_HTS44_81.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>324_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 1_HTS44_81.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401480" alias="327_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 1_HTS44_84.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401480</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">327_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 1_HTS44_84.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695616">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695616</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">327_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 1_HTS44_84.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>327_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 1_HTS44_84.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401481" alias="326_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 1_HTS44_83.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401481</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">326_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 1_HTS44_83.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695617">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695617</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">326_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 1_HTS44_83.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>326_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 1_HTS44_83.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401482" alias="329_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 2_HTS44_98.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401482</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">329_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 2_HTS44_98.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695618">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695618</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">329_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 2_HTS44_98.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>329_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 2_HTS44_98.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401483" alias="328_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 2_HTS44_97.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401483</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">328_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 2_HTS44_97.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695619">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695619</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">328_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 2_HTS44_97.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>328_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 2_HTS44_97.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401484" alias="331_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 2_HTS44_100.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401484</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">331_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 2_HTS44_100.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695620">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695620</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">331_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 2_HTS44_100.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>331_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 2_HTS44_100.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401485" alias="330_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 2_HTS44_99.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401485</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">330_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 2_HTS44_99.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695621">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695621</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">330_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 2_HTS44_99.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>330_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 2_HTS44_99.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401486" alias="242_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 3_HTS40_23.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401486</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">242_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 3_HTS40_23.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695622">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695622</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">242_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 3_HTS40_23.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>242_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 3_HTS40_23.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401487" alias="206_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 3_HTS40_19.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401487</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">206_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 3_HTS40_19.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695623">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695623</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">206_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 3_HTS40_19.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>206_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 3_HTS40_19.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401488" alias="410-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-12.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401488</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">410-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-12.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695624">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695624</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">410-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-12.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>410-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-12.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401489" alias="411-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-13.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401489</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">411-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-13.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695627">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695627</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">411-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-13.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>411-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-13.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401490" alias="412-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-14.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401490</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">412-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-14.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695626">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695626</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">412-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-14.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>412-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-14.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401491" alias="413-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-15.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401491</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">413-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-15.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695629">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695629</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">413-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-15.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>413-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-15.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401492" alias="414-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-16.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401492</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">414-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-16.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695628">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695628</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">414-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-16.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>414-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-16.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401493" alias="298_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 2_HTS44_31.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401493</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">298_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 2_HTS44_31.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695631">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695631</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">298_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 2_HTS44_31.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>298_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 2_HTS44_31.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401494" alias="299_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 2_HTS44_32.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401494</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">299_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 2_HTS44_32.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695630">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695630</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">299_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 2_HTS44_32.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>299_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 2_HTS44_32.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401495" alias="300_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 2_HTS44_33.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401495</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">300_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 2_HTS44_33.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695632">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695632</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">300_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 2_HTS44_33.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>300_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 2_HTS44_33.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401496" alias="301_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 2_HTS44_34.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401496</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">301_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 2_HTS44_34.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695633">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695633</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">301_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 2_HTS44_34.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>301_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 2_HTS44_34.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401497" alias="294_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 2_HTS44_27.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401497</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">294_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 2_HTS44_27.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695634">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695634</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">294_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 2_HTS44_27.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>294_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 2_HTS44_27.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401498" alias="295_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 2_HTS44_28.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401498</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">295_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 2_HTS44_28.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695635">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695635</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">295_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 2_HTS44_28.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>295_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 2_HTS44_28.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401499" alias="296_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 2_HTS44_29.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401499</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">296_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 2_HTS44_29.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695636">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695636</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">296_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 2_HTS44_29.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>296_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 2_HTS44_29.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401500" alias="297_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 2_HTS44_30.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401500</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">297_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 2_HTS44_30.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695637">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695637</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">297_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 2_HTS44_30.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>297_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 2_HTS44_30.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401501" alias="302_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 2_HTS44_35.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401501</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">302_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 2_HTS44_35.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695638">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695638</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">302_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 2_HTS44_35.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>302_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipo2000_replicate 2_HTS44_35.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401502" alias="303_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS44_36.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401502</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">303_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS44_36.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695639">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695639</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">303_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS44_36.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>303_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 2_HTS44_36.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401503" alias="222_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 3_HTS40_59.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401503</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">222_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 3_HTS40_59.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695640">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695640</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">222_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 3_HTS40_59.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>222_BthBth fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 3_HTS40_59.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401504" alias="223_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 3_HTS40_60.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401504</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">223_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 3_HTS40_60.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695641">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695641</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">223_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 3_HTS40_60.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>223_BthBth fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 3_HTS40_60.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401505" alias="234_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 2_HTS40_9.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401505</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">234_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 2_HTS40_9.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695643">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695643</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">234_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 2_HTS40_9.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>234_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 2_HTS40_9.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401506" alias="235_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 2_HTS40_10.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401506</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">235_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 2_HTS40_10.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695644">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695644</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">235_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 2_HTS40_10.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>235_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 2_HTS40_10.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401507" alias="389-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-21.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401507</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">389-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-21.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695646">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695646</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">389-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-21.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>389-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-21.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401508" alias="236_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 2_HTS40_11.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401508</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">236_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 2_HTS40_11.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695645">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695645</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">236_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 2_HTS40_11.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>236_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 2_HTS40_11.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401509" alias="407-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-9.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401509</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">407-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-9.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695647">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695647</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">407-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-9.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>407-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-9.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401510" alias="406-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-8.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401510</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">406-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-8.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695648">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695648</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">406-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-8.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>406-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-8.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401511" alias="405-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-7.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401511</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">405-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-7.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695649">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695649</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">405-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-7.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>405-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-7.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401512" alias="404-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-6.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401512</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">404-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-6.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695650">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695650</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">404-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-6.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>404-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-6.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401513" alias="403-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-5.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401513</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">403-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-5.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695651">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695651</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">403-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-5.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>403-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-5.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401514" alias="402-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-4.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401514</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">402-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-4.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695652">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695652</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">402-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-4.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>402-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-4.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401515" alias="401-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-3.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401515</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">401-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-3.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695653">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695653</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">401-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-3.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>401-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-3.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401516" alias="400-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-2.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401516</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">400-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-2.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695654">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695654</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">400-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-2.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>400-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-2.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401517" alias="238_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 2_HTS40_13.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401517</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">238_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 2_HTS40_13.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695655">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695655</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">238_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 2_HTS40_13.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>238_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 2_HTS40_13.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401518" alias="409-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-11.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401518</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">409-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-11.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695656">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695656</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">409-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-11.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>409-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-11.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401519" alias="408-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-10.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401519</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">408-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-10.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695657">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695657</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">408-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-10.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>408-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-10.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401520" alias="220_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 3_HTS40_57.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401520</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">220_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 3_HTS40_57.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695658">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695658</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">220_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 3_HTS40_57.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>220_BthBth fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 3_HTS40_57.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401521" alias="240_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 3_HTS40_21.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401521</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">240_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 3_HTS40_21.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695659">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695659</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">240_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 3_HTS40_21.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>240_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_LPF2000_replicate 3_HTS40_21.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401522" alias="211_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 4_HTS40_32.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401522</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">211_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 4_HTS40_32.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695660">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695660</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">211_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 4_HTS40_32.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>211_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 4_HTS40_32.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401523" alias="307_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 3_HTS44_52.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401523</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">307_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 3_HTS44_52.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695661">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695661</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">307_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 3_HTS44_52.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>307_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 3_HTS44_52.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401524" alias="306_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 3_HTS44_51.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401524</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">306_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 3_HTS44_51.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695662">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695662</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">306_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 3_HTS44_51.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>306_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 3_HTS44_51.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401525" alias="305_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 3_HTS44_50.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401525</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">305_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 3_HTS44_50.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695663">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695663</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">305_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 3_HTS44_50.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>305_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 3_HTS44_50.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401526" alias="304_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 3_HTS44_49.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401526</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">304_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 3_HTS44_49.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695664">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695664</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">304_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 3_HTS44_49.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>304_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 3_HTS44_49.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401527" alias="311_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 3_HTS44_56.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401527</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">311_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 3_HTS44_56.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695665">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695665</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">311_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 3_HTS44_56.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>311_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 8_replicate 3_HTS44_56.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401528" alias="310_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 3_HTS44_55.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401528</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">310_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 3_HTS44_55.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695667">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695667</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">310_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 3_HTS44_55.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>310_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 7_replicate 3_HTS44_55.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401529" alias="309_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 3_HTS44_54.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401529</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">309_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 3_HTS44_54.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695666">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695666</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">309_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 3_HTS44_54.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>309_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 6_replicate 3_HTS44_54.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401530" alias="308_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 3_HTS44_53.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401530</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">308_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 3_HTS44_53.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695668">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695668</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">308_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 3_HTS44_53.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>308_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 5_replicate 3_HTS44_53.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401531" alias="313_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 3_HTS44_58.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401531</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">313_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 3_HTS44_58.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695669">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695669</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">313_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 3_HTS44_58.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>313_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 10_replicate 3_HTS44_58.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401532" alias="312_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 3_HTS44_57.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401532</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">312_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 3_HTS44_57.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695670">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695670</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">312_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 3_HTS44_57.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>312_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 9_replicate 3_HTS44_57.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401533" alias="252_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 4_HTS40_39.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401533</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">252_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 4_HTS40_39.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695671">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695671</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">252_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 4_HTS40_39.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>252_WT fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 4_HTS40_39.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401534" alias="221_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 3_HTS40_58.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401534</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">221_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 3_HTS40_58.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695673">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695673</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">221_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 3_HTS40_58.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>221_BthBth fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 3_HTS40_58.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401535" alias="379_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 2_HTS44_118.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401535</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">379_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 2_HTS44_118.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695672">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695672</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">379_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 2_HTS44_118.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>379_BthBth fibroblast-SaCas9KKH-Tmc1-7-100 nM-Tmc1-replicate 2_HTS44_118.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401536" alias="237_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 2_HTS40_12.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401536</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">237_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 2_HTS40_12.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695674">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695674</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">237_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 2_HTS40_12.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>237_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 2_HTS40_12.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401537" alias="210_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 4_HTS40_31.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401537</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">210_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 4_HTS40_31.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695675">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695675</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">210_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 4_HTS40_31.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>210_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 4_HTS40_31.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401538" alias="392-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-45.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401538</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">392-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-45.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695677">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695677</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">392-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-45.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>392-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-45.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401539" alias="393-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-46.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401539</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">393-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-46.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695676">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695676</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">393-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-46.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>393-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-46.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401540" alias="390-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-27.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401540</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">390-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-27.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695678">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695678</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">390-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-27.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>390-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-27.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401541" alias="391-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-31.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401541</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">391-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-31.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695679">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695679</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">391-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-31.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>391-Bth+ mice-injected with Cas9 Tmc1-mut3-purified haircells-Tmc1-HTS43-31.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401542" alias="396-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-49.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401542</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">396-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-49.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695680">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695680</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">396-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-49.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>396-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-49.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401543" alias="397-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-51.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401543</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">397-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-51.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695681">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695681</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">397-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-51.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>397-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-51.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401544" alias="394-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-47.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401544</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">394-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-47.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695682">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695682</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">394-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-47.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>394-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-47.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401545" alias="395-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-48.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401545</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">395-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-48.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695683">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695683</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">395-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-48.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>395-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-48.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401546" alias="398-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-52.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401546</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">398-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-52.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695684">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695684</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">398-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-52.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>398-Bth+ mice-uninjected-purified haircells-Tmc1-HTS43-52.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401547" alias="399-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-1.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401547</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">399-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-1.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695685">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695685</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">399-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-1.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>399-Bth+ mice-uninjected-purified haircells-Tmc1-HTS45-1.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401548" alias="205_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 3_HTS40_18.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401548</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">205_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 3_HTS40_18.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695720">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695720</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">205_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 3_HTS40_18.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>205_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 3_HTS40_18.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401549" alias="249_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 4_HTS40_36.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401549</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">249_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 4_HTS40_36.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695686">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695686</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">249_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 4_HTS40_36.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>249_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_RNAiMAX_replicate 4_HTS40_36.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401550" alias="204_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 3_HTS40_17.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401550</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">204_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 3_HTS40_17.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695687">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695687</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">204_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 3_HTS40_17.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>204_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 3_HTS40_17.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401551" alias="202_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 3_HTS40_15.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401551</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">202_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 3_HTS40_15.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695688">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695688</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">202_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 3_HTS40_15.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>202_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 3_HTS40_15.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401552" alias="203_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 3_HTS40_16.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401552</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">203_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 3_HTS40_16.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695689">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695689</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">203_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 3_HTS40_16.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>203_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 3_HTS40_16.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401553" alias="198_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 2_HTS40_3.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401553</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">198_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 2_HTS40_3.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695690">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695690</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">198_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 2_HTS40_3.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>198_WT fibroblast-Cas9-Tmc1-wt3-Tmc1_replicate 2_HTS40_3.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401554" alias="199_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 2_HTS40_4.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401554</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">199_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 2_HTS40_4.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695691">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695691</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">199_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 2_HTS40_4.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>199_WT fibroblast-Cas9-Tmc1-mut1-Tmc1_replicate 2_HTS40_4.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401555" alias="200_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 2_HTS40_5.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401555</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">200_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 2_HTS40_5.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695692">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695692</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">200_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 2_HTS40_5.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>200_WT fibroblast-Cas9-Tmc1-mut2-Tmc1_replicate 2_HTS40_5.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401556" alias="201_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 2_HTS40_6.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401556</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">201_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 2_HTS40_6.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695693">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695693</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">201_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 2_HTS40_6.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>201_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 2_HTS40_6.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401557" alias="194_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 3_HTS44_137.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401557</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">194_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 3_HTS44_137.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695694">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695694</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">194_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 3_HTS44_137.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>194_Bthbth fibroblast-Cas9-Tmc1-mut3-200 nM-Tmc1-replicate 3_HTS44_137.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401558" alias="195_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 3_HTS44_138.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401558</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">195_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 3_HTS44_138.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695695">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695695</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">195_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 3_HTS44_138.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>195_Bthbth fibroblast-Cas9-Tmc1-mut3-400 nM-Tmc1-replicate 3_HTS44_138.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401559" alias="196_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 2_HTS40_1.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401559</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">196_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 2_HTS40_1.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695696">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695696</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">196_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 2_HTS40_1.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>196_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 2_HTS40_1.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401560" alias="197_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 2_HTS40_2.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401560</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">197_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 2_HTS40_2.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695697">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695697</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">197_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 2_HTS40_2.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>197_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 2_HTS40_2.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401561" alias="209_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 4_HTS40_30.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401561</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">209_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 4_HTS40_30.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695698">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695698</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">209_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 4_HTS40_30.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>209_WT fibroblast-Cas9-Tmc1-wt2-Tmc1_replicate 4_HTS40_30.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401562" alias="250_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 4_HTS40_37.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401562</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">250_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 4_HTS40_37.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695699">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695699</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">250_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 4_HTS40_37.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>250_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 4_HTS40_37.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401563" alias="208_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 4_HTS40_29.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401563</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">208_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 4_HTS40_29.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695700">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695700</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">208_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 4_HTS40_29.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>208_WT fibroblast-Cas9-Tmc1-wt1-Tmc1_replicate 4_HTS40_29.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401564" alias="280_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 1_HTS44_1.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401564</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">280_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 1_HTS44_1.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695701">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695701</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">280_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 1_HTS44_1.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>280_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 1_replicate 1_HTS44_1.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401565" alias="281_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 1_HTS44_2.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401565</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">281_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 1_HTS44_2.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695702">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695702</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">281_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 1_HTS44_2.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>281_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 2_replicate 1_HTS44_2.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401566" alias="278_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 4_HTS40_83.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401566</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">278_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 4_HTS40_83.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695703">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695703</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">278_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 4_HTS40_83.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>278_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_LTX_replicate 4_HTS40_83.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401567" alias="279_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 4_HTS40_84.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401567</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">279_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 4_HTS40_84.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695704">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695704</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">279_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 4_HTS40_84.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>279_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_no lipid_replicate 4_HTS40_84.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401568" alias="276_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 4_HTS40_81.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401568</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">276_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 4_HTS40_81.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695705">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695705</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">276_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 4_HTS40_81.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>276_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1-LPF3000_replicate 4_HTS40_81.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401569" alias="277_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 4_HTS40_82.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401569</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">277_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 4_HTS40_82.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695706">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695706</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">277_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 4_HTS40_82.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>277_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_CRISPERMAX_replicate 4_HTS40_82.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401570" alias="274_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 4_HTS40_79.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401570</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">274_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 4_HTS40_79.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695707">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695707</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">274_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 4_HTS40_79.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>274_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_DMRIE-c_replicate 4_HTS40_79.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401571" alias="275_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 4_HTS40_80.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401571</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">275_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 4_HTS40_80.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695708">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695708</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">275_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 4_HTS40_80.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>275_BthBth fibroblast-Cas9-Tmc1-mut3-Tmc1_IBAfect_replicate 4_HTS40_80.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401572" alias="213_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 4_HTS40_34.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401572</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">213_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 4_HTS40_34.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695709">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695709</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">213_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 4_HTS40_34.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>213_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_replicate 4_HTS40_34.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401573" alias="282_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 1_HTS44_3.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401573</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">282_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 1_HTS44_3.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695710">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695710</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">282_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 1_HTS44_3.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>282_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 3_replicate 1_HTS44_3.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX3401574" alias="283_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 1_HTS44_4.fastq">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3401574</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB3226560">283_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 1_HTS44_4.fastq</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>treatment of genetic hearing disease</TITLE>
    <STUDY_REF accession="SRP103108">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP103108</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA381788</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>sample derived from mouse</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS2695711">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2695711</PRIMARY_ID>
          <SUBMITTER_ID namespace="pda|gaoxueucla">283_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 1_HTS44_4.fastq</SUBMITTER_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>283_WT fibroblast-Cas9-Tmc1-mut3-Tmc1_lipid 4_replicate 1_HTS44_4.fastq</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
</EXPERIMENT_SET>
