SRX3423882 GSM2865285 SRP125667 SRS2715523 GSM2865285 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted by PureLink Genomic DNA Mini Kit, then quantified by Nanodrop 2000c and Qubit(Thermo Scientific) according to the manufactor's instruction. Library preparation was performed with SureSelect Mouse Methyl-Seq Reagent Kit(Agilent Technologies), which could enrich about 100 Mb of mouse genomic regions including CpG island, promoters, Dnase I hypersensitive sites and tissue-specific DMRs. DNA was bisulfite-treated using EZ DNA Methylation-Gold Kit. Sequencing libries were assessed by Bioanalyzer and quantified with KAPA Library Quantification Kits. The libraries were then sequenced on HiSeq 2500 (2X50 bp paired-end reads) Illumina HiSeq 2500 gds 302865285 GSM2865285 GEO Accession GSM2865285 SRX3423883 GSM2865286 SRP125667 SRS2715524 GSM2865286 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted by PureLink Genomic DNA Mini Kit, then quantified by Nanodrop 2000c and Qubit(Thermo Scientific) according to the manufactor's instruction. Library preparation was performed with SureSelect Mouse Methyl-Seq Reagent Kit(Agilent Technologies), which could enrich about 100 Mb of mouse genomic regions including CpG island, promoters, Dnase I hypersensitive sites and tissue-specific DMRs. DNA was bisulfite-treated using EZ DNA Methylation-Gold Kit. Sequencing libries were assessed by Bioanalyzer and quantified with KAPA Library Quantification Kits. The libraries were then sequenced on HiSeq 2500 (2X50 bp paired-end reads) Illumina HiSeq 2500 gds 302865286 GSM2865286 GEO Accession GSM2865286