SRX3432965 GSM2870523 SRP125875 SRS2724363 GSM2870523 Bisulfite-Seq GENOMIC Reduced Representation Around 3×106 cells were harvested by 0.25 % trypsin digestion. DNA was extracted according to the instructions of Wizard® Genomic DNA Purification Kit (Promega A1125). Purity of DNA was determined by K5500 spectrophotometer, DNA quantification was performed using Qubit® 3.0 Fluorometer. DNA was digested by MspI followed by end-repaired. The 3'end of the end-repaired, phosphorylated fragments were tailed with dA, and the single A overhangs were ligated by the methylated adaptors. Library fragments of 40~220 bp were band isolated from 2% agarose gel, converted by bisulfite treatment, and amplified by PCR. The RRBS library was sequenced on an Illumina HiSeq2500 Analyzer platform paired-end 50 bp reads. Illumina HiSeq 2500 gds 302870523 GSM2870523 GEO Accession GSM2870523 SRX3432966 GSM2870524 SRP125875 SRS2724364 GSM2870524 Bisulfite-Seq GENOMIC Reduced Representation Around 3×106 cells were harvested by 0.25 % trypsin digestion. DNA was extracted according to the instructions of Wizard® Genomic DNA Purification Kit (Promega A1125). Purity of DNA was determined by K5500 spectrophotometer, DNA quantification was performed using Qubit® 3.0 Fluorometer. DNA was digested by MspI followed by end-repaired. The 3'end of the end-repaired, phosphorylated fragments were tailed with dA, and the single A overhangs were ligated by the methylated adaptors. Library fragments of 40~220 bp were band isolated from 2% agarose gel, converted by bisulfite treatment, and amplified by PCR. The RRBS library was sequenced on an Illumina HiSeq2500 Analyzer platform paired-end 50 bp reads. Illumina HiSeq 2500 gds 302870524 GSM2870524 GEO Accession GSM2870524 SRX3432967 GSM2870525 SRP125875 SRS2724365 GSM2870525 Bisulfite-Seq GENOMIC Reduced Representation Around 3×106 cells were harvested by 0.25 % trypsin digestion. DNA was extracted according to the instructions of Wizard® Genomic DNA Purification Kit (Promega A1125). Purity of DNA was determined by K5500 spectrophotometer, DNA quantification was performed using Qubit® 3.0 Fluorometer. DNA was digested by MspI followed by end-repaired. The 3'end of the end-repaired, phosphorylated fragments were tailed with dA, and the single A overhangs were ligated by the methylated adaptors. Library fragments of 40~220 bp were band isolated from 2% agarose gel, converted by bisulfite treatment, and amplified by PCR. The RRBS library was sequenced on an Illumina HiSeq2500 Analyzer platform paired-end 50 bp reads. Illumina HiSeq 2500 gds 302870525 GSM2870525 GEO Accession GSM2870525 SRX3432968 GSM2870526 SRP125875 SRS2724366 GSM2870526 Bisulfite-Seq GENOMIC Reduced Representation Around 3×106 cells were harvested by 0.25 % trypsin digestion. DNA was extracted according to the instructions of Wizard® Genomic DNA Purification Kit (Promega A1125). Purity of DNA was determined by K5500 spectrophotometer, DNA quantification was performed using Qubit® 3.0 Fluorometer. DNA was digested by MspI followed by end-repaired. The 3'end of the end-repaired, phosphorylated fragments were tailed with dA, and the single A overhangs were ligated by the methylated adaptors. Library fragments of 40~220 bp were band isolated from 2% agarose gel, converted by bisulfite treatment, and amplified by PCR. The RRBS library was sequenced on an Illumina HiSeq2500 Analyzer platform paired-end 50 bp reads. Illumina HiSeq 2500 gds 302870526 GSM2870526 GEO Accession GSM2870526