<?xml version="1.0" encoding="UTF-8"?>
<EXPERIMENT_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <EXPERIMENT alias="GSM2878192" accession="SRX3450354">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450354</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878192</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878192: G00229; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739288">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739288</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878192</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878192</ID>
          <LABEL>GSM2878192</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878192</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878193" accession="SRX3450355">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450355</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878193</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878193: G00230; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739287">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739287</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878193</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878193</ID>
          <LABEL>GSM2878193</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878193</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878194" accession="SRX3450356">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450356</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878194</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878194: G00231; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739289">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739289</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878194</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878194</ID>
          <LABEL>GSM2878194</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878194</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878195" accession="SRX3450357">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450357</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878195</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878195: G00232; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739290">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739290</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878195</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878195</ID>
          <LABEL>GSM2878195</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878195</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878196" accession="SRX3450358">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450358</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878196</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878196: G00233; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739292">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739292</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878196</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878196</ID>
          <LABEL>GSM2878196</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878196</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878197" accession="SRX3450359">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450359</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878197</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878197: G00234; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739291">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739291</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878197</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878197</ID>
          <LABEL>GSM2878197</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878197</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878198" accession="SRX3450360">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450360</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878198</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878198: G00235; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739293">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739293</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878198</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878198</ID>
          <LABEL>GSM2878198</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878198</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878199" accession="SRX3450361">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450361</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878199</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878199: G00236; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739294">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739294</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878199</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878199</ID>
          <LABEL>GSM2878199</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878199</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878200" accession="SRX3450362">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450362</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878200</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878200: G00237; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739295">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739295</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878200</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878200</ID>
          <LABEL>GSM2878200</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878200</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878201" accession="SRX3450363">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450363</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878201</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878201: G00238; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739296">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739296</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878201</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878201</ID>
          <LABEL>GSM2878201</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878201</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878202" accession="SRX3450364">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450364</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878202</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878202: G00239; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739297">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739297</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878202</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878202</ID>
          <LABEL>GSM2878202</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878202</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878203" accession="SRX3450365">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450365</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878203</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878203: G00240; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739298">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739298</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878203</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878203</ID>
          <LABEL>GSM2878203</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878203</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878204" accession="SRX3450366">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450366</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878204</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878204: G00241; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739299">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739299</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878204</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878204</ID>
          <LABEL>GSM2878204</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878204</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878205" accession="SRX3450367">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450367</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878205</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878205: G00242; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739300">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739300</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878205</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878205</ID>
          <LABEL>GSM2878205</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878205</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878206" accession="SRX3450368">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450368</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878206</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878206: G00243; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739301">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739301</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878206</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878206</ID>
          <LABEL>GSM2878206</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878206</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878207" accession="SRX3450369">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450369</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878207</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878207: G00244; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739302">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739302</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878207</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878207</ID>
          <LABEL>GSM2878207</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878207</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878208" accession="SRX3450370">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450370</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878208</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878208: G00245; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739305">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739305</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878208</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878208</ID>
          <LABEL>GSM2878208</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878208</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878209" accession="SRX3450371">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450371</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878209</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878209: G00246; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739303">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739303</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878209</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878209</ID>
          <LABEL>GSM2878209</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878209</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878210" accession="SRX3450372">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450372</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878210</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878210: G00247; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739306">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739306</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878210</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878210</ID>
          <LABEL>GSM2878210</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878210</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878211" accession="SRX3450373">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450373</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878211</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878211: G00248; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739304">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739304</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878211</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878211</ID>
          <LABEL>GSM2878211</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878211</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878212" accession="SRX3450374">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450374</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878212</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878212: G00249; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739307">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739307</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878212</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878212</ID>
          <LABEL>GSM2878212</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878212</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878213" accession="SRX3450375">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450375</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878213</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878213: G00250; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739308">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739308</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878213</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878213</ID>
          <LABEL>GSM2878213</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878213</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878214" accession="SRX3450376">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450376</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878214</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878214: G00251; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739311">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739311</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878214</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878214</ID>
          <LABEL>GSM2878214</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878214</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878215" accession="SRX3450377">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450377</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878215</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878215: G00252; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739310">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739310</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878215</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878215</ID>
          <LABEL>GSM2878215</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878215</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878216" accession="SRX3450378">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450378</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878216</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878216: G00253; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739309">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739309</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878216</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878216</ID>
          <LABEL>GSM2878216</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878216</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878217" accession="SRX3450379">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450379</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878217</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878217: G00254; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739312">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739312</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878217</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878217</ID>
          <LABEL>GSM2878217</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878217</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878218" accession="SRX3450380">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450380</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878218</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878218: G00255; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739313">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739313</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878218</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878218</ID>
          <LABEL>GSM2878218</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878218</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878219" accession="SRX3450381">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450381</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878219</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878219: G00256; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739315">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739315</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878219</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878219</ID>
          <LABEL>GSM2878219</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878219</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878220" accession="SRX3450382">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450382</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878220</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878220: G00257; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739314">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739314</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878220</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878220</ID>
          <LABEL>GSM2878220</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878220</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878221" accession="SRX3450383">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450383</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878221</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878221: G00258; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739316">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739316</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878221</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878221</ID>
          <LABEL>GSM2878221</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878221</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878222" accession="SRX3450384">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450384</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878222</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878222: G00259; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739317">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739317</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878222</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878222</ID>
          <LABEL>GSM2878222</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878222</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878223" accession="SRX3450385">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450385</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878223</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878223: G00260; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739318">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739318</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878223</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878223</ID>
          <LABEL>GSM2878223</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878223</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878224" accession="SRX3450386">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450386</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878224</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878224: G00261; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739319">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739319</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878224</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878224</ID>
          <LABEL>GSM2878224</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878224</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878225" accession="SRX3450387">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450387</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878225</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878225: G00262; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739320">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739320</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878225</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878225</ID>
          <LABEL>GSM2878225</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878225</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878226" accession="SRX3450388">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450388</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878226</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878226: G00263; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739321">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739321</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878226</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878226</ID>
          <LABEL>GSM2878226</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878226</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878227" accession="SRX3450389">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450389</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878227</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878227: G00264; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739322">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739322</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878227</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878227</ID>
          <LABEL>GSM2878227</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878227</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878228" accession="SRX3450390">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450390</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878228</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878228: G00265; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739323">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739323</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878228</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878228</ID>
          <LABEL>GSM2878228</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878228</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878229" accession="SRX3450391">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450391</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878229</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878229: G00266; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739324">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739324</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878229</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878229</ID>
          <LABEL>GSM2878229</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878229</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2878230" accession="SRX3450392">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3450392</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2878230</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2878230: G00267; Mus musculus; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP126245" refname="GSE107759">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP126245</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2739325">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2739325</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2878230</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Tumor tissue and surrounding unaffected tissue of Apc Min/+ and Apc Min/+ ::ADAM17 ex/ex mice were prepared freshly. To isolate total RNA from animal tissue for RNA sequencing, the RNeasy Mini Kit from Qiagen (Hilden, Germany) was used according to supplier's instructions including a QIAshredder column from Qiagen. Individual strand-specific sequencing libraries were prepared with the TruSeq stranded mRNA kit (Illumina) from 500 ng total RNA.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 3000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302878230</ID>
          <LABEL>GSM2878230</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2878230</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
</EXPERIMENT_SET>
