SRX3464623 GSM2885089 SRP126573 SRS2752600 GSM2885089 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885089 GSM2885089 GEO Accession GSM2885089 SRX3464624 GSM2885090 SRP126573 SRS2752589 GSM2885090 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885090 GSM2885090 GEO Accession GSM2885090 SRX3464625 GSM2885091 SRP126573 SRS2752592 GSM2885091 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885091 GSM2885091 GEO Accession GSM2885091 SRX3464626 GSM2885092 SRP126573 SRS2752617 GSM2885092 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885092 GSM2885092 GEO Accession GSM2885092 SRX3464627 GSM2885093 SRP126573 SRS2752591 GSM2885093 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885093 GSM2885093 GEO Accession GSM2885093 SRX3464628 GSM2885094 SRP126573 SRS2752609 GSM2885094 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885094 GSM2885094 GEO Accession GSM2885094 SRX3464629 GSM2885095 SRP126573 SRS2752594 GSM2885095 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885095 GSM2885095 GEO Accession GSM2885095 SRX3464630 GSM2885096 SRP126573 SRS2752615 GSM2885096 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885096 GSM2885096 GEO Accession GSM2885096 SRX3464631 GSM2885097 SRP126573 SRS2752622 GSM2885097 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885097 GSM2885097 GEO Accession GSM2885097 SRX3464632 GSM2885098 SRP126573 SRS2752597 GSM2885098 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885098 GSM2885098 GEO Accession GSM2885098 SRX3464633 GSM2885099 SRP126573 SRS2752630 GSM2885099 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885099 GSM2885099 GEO Accession GSM2885099 SRX3464634 GSM2885100 SRP126573 SRS2752628 GSM2885100 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885100 GSM2885100 GEO Accession GSM2885100 SRX3464635 GSM2885101 SRP126573 SRS2752621 GSM2885101 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885101 GSM2885101 GEO Accession GSM2885101 SRX3464636 GSM2885102 SRP126573 SRS2752604 GSM2885102 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885102 GSM2885102 GEO Accession GSM2885102 SRX3464637 GSM2885103 SRP126573 SRS2752602 GSM2885103 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885103 GSM2885103 GEO Accession GSM2885103 SRX3464638 GSM2885104 SRP126573 SRS2752649 GSM2885104 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885104 GSM2885104 GEO Accession GSM2885104 SRX3464639 GSM2885105 SRP126573 SRS2752618 GSM2885105 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885105 GSM2885105 GEO Accession GSM2885105 SRX3464640 GSM2885106 SRP126573 SRS2752605 GSM2885106 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885106 GSM2885106 GEO Accession GSM2885106 SRX3464641 GSM2885107 SRP126573 SRS2752620 GSM2885107 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885107 GSM2885107 GEO Accession GSM2885107 SRX3464642 GSM2885108 SRP126573 SRS2752610 GSM2885108 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885108 GSM2885108 GEO Accession GSM2885108 SRX3464643 GSM2885109 SRP126573 SRS2752611 GSM2885109 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885109 GSM2885109 GEO Accession GSM2885109 SRX3464644 GSM2885110 SRP126573 SRS2752612 GSM2885110 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885110 GSM2885110 GEO Accession GSM2885110 SRX3464645 GSM2885111 SRP126573 SRS2752613 GSM2885111 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885111 GSM2885111 GEO Accession GSM2885111 SRX3464646 GSM2885112 SRP126573 SRS2752614 GSM2885112 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885112 GSM2885112 GEO Accession GSM2885112 SRX3464647 GSM2885113 SRP126573 SRS2752624 GSM2885113 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885113 GSM2885113 GEO Accession GSM2885113 SRX3464648 GSM2885114 SRP126573 SRS2752627 GSM2885114 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885114 GSM2885114 GEO Accession GSM2885114 SRX3464649 GSM2885115 SRP126573 SRS2752639 GSM2885115 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885115 GSM2885115 GEO Accession GSM2885115 SRX3464650 GSM2885116 SRP126573 SRS2752651 GSM2885116 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885116 GSM2885116 GEO Accession GSM2885116 SRX3464651 GSM2885117 SRP126573 SRS2752635 GSM2885117 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885117 GSM2885117 GEO Accession GSM2885117 SRX3464652 GSM2885118 SRP126573 SRS2752619 GSM2885118 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885118 GSM2885118 GEO Accession GSM2885118 SRX3464653 GSM2885119 SRP126573 SRS2752623 GSM2885119 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885119 GSM2885119 GEO Accession GSM2885119 SRX3464654 GSM2885120 SRP126573 SRS2752626 GSM2885120 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885120 GSM2885120 GEO Accession GSM2885120 SRX3464655 GSM2885121 SRP126573 SRS2752640 GSM2885121 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885121 GSM2885121 GEO Accession GSM2885121 SRX3464656 GSM2885122 SRP126573 SRS2752625 GSM2885122 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885122 GSM2885122 GEO Accession GSM2885122 SRX3464657 GSM2885123 SRP126573 SRS2752632 GSM2885123 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885123 GSM2885123 GEO Accession GSM2885123 SRX3464658 GSM2885124 SRP126573 SRS2752633 GSM2885124 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885124 GSM2885124 GEO Accession GSM2885124 SRX3464659 GSM2885125 SRP126573 SRS2752636 GSM2885125 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885125 GSM2885125 GEO Accession GSM2885125 SRX3464660 GSM2885126 SRP126573 SRS2752638 GSM2885126 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885126 GSM2885126 GEO Accession GSM2885126 SRX3464661 GSM2885127 SRP126573 SRS2752629 GSM2885127 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885127 GSM2885127 GEO Accession GSM2885127 SRX3464662 GSM2885128 SRP126573 SRS2752631 GSM2885128 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885128 GSM2885128 GEO Accession GSM2885128 SRX3464663 GSM2885129 SRP126573 SRS2752634 GSM2885129 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885129 GSM2885129 GEO Accession GSM2885129 SRX3464664 GSM2885130 SRP126573 SRS2752637 GSM2885130 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885130 GSM2885130 GEO Accession GSM2885130 SRX3464665 GSM2885131 SRP126573 SRS2752647 GSM2885131 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885131 GSM2885131 GEO Accession GSM2885131 SRX3464666 GSM2885132 SRP126573 SRS2752657 GSM2885132 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885132 GSM2885132 GEO Accession GSM2885132 SRX3464667 GSM2885133 SRP126573 SRS2752653 GSM2885133 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885133 GSM2885133 GEO Accession GSM2885133 SRX3464668 GSM2885134 SRP126573 SRS2752655 GSM2885134 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885134 GSM2885134 GEO Accession GSM2885134 SRX3464669 GSM2885135 SRP126573 SRS2752658 GSM2885135 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885135 GSM2885135 GEO Accession GSM2885135 SRX3464670 GSM2885136 SRP126573 SRS2752641 GSM2885136 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885136 GSM2885136 GEO Accession GSM2885136 SRX3464671 GSM2885137 SRP126573 SRS2752643 GSM2885137 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885137 GSM2885137 GEO Accession GSM2885137 SRX3464672 GSM2885138 SRP126573 SRS2752652 GSM2885138 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885138 GSM2885138 GEO Accession GSM2885138 SRX3464673 GSM2885139 SRP126573 SRS2752644 GSM2885139 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885139 GSM2885139 GEO Accession GSM2885139 SRX3464674 GSM2885140 SRP126573 SRS2752642 GSM2885140 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885140 GSM2885140 GEO Accession GSM2885140 SRX3464675 GSM2885141 SRP126573 SRS2752656 GSM2885141 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885141 GSM2885141 GEO Accession GSM2885141 SRX3464676 GSM2885142 SRP126573 SRS2752673 GSM2885142 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885142 GSM2885142 GEO Accession GSM2885142 SRX3464677 GSM2885143 SRP126573 SRS2752685 GSM2885143 OTHER GENOMIC other Exogenously introduced genomic DNA was isolated Quick gDNA micro prep kit (Zymo research) Custom barcodes and Illumina adapters was used for library constructions. Illumina HiSeq 2500 gds 302885143 GSM2885143 GEO Accession GSM2885143 SRX4159281 GSM3173913 SRP126573 PRJNA422111 SRS3371665 GSM3173913 ChIP-Seq GENOMIC ChIP Reprogramming cells (7.5-10 x 106 cells per sample were collected by trypsinization at day 3 and 6 days post transduction and washed twice with PBS (Gibco). Cells were resuspended in PBS at a density of 5 x 105/mL and then chemically crosslinked by the addition of 1% formaldehyde for 10 min at room temperature with gentle rotation. Crosslinking was stopped by the addition of glycine to a final concentration of 125 mM for 5 min at room temperature. Cells were washed twice with 10 mL cold PBS and lysed in 10 mL Lysis Buffer 1 (150 mM NaCl, 0.5% NP40; 1 mM EDTA, 10% glycerol, 0.25% triton-X100, freshly added complete proteinase inhibitor cocktail in 15 mL tubes at 4°C for 10 min with gentle rocking. The lysate was centrifuged for 10 min at 1350 x g at 4°C. The supernatant was discarded and the pellet was resuspended in 10 mL lysis buffer 2 (10 mM Tris-HCl, pH 8.0, 200 mM NaCl, 1 mM EDTA, 0.5 mM EGTA, protease inhibitor) incubated at 4°C for 10 min. The procedure was repeated using 10 mL lysis buffer 3 (1% SDS, 10 mM EDTA, 50 mM Tris-HCl, pH 8.0, protease inhibitor) and 10 min rocking at RT. Nuclei were collected by centrifugation and washed twice with sonication buffer (10 mM Tris-HCl, pH 8.0, 0.5 mM EDTA, protease inhibitor) and finally suspended in sonication buffer. Samples were sonicated using a Covaris S220 machine with settings to obtain DNA fragments with a length from 150 to 500 bp using microTUBEs (130 μL) for 5 cycles of 30 sec ON and 60 sec OFF using default settings recommended for microTUBEs. 10% Triton-X100 was added and the lysate was centrifuged at high speed (20000 x g for 10 min at 4°C). 1/10 of the supernatant was stored as input control. ChIP was performed in an automated fashion using the IP-Star compacted automated system (Diagenode) using 6 g ChIP-grade antibodies and 50 l protein G Dynabeads (Invitrogen). The coupling time for beads and antibody was 5 hours followed by incubation with lysate for 15 hours at 4°C. Automated wash steps of 10 minutes at 4°C were performed in the following order: low salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 150 mM NaCl) , high salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 500 mM NaCl), LiCl buffer (500 mM LiCl, 50 mM Tris-HCl pH 8.0, 2 mM EDTA, 1% NP-40, 0.5% Na-deoxycholate), TE buffer (10 mM Tris-HCl pH 8.0, 1 mM EDTA) with final elution in 10 mM Tris-HCl pH 8.0, 1 mM EDTA, 1% SDS buffer. The eluted chromatin and input samples were reverse‐crosslinked by overnight incubation at 65°C. Samples were treated with RNaseA (0.2 mg/ml final concentration) at 37°C for 2h followed by proteinase K (0.2 g/ml final conc.) at 55°C for 3 hours. DNA was extracted by phenol:chloroform:isoamyl alcohol (25:24:1) and phase separated using heavy phase-lock tubes (TianGen) by centrifugation at 10000 rpm for 10 min at RT and precipitated with 100% ethanol with 20 μg/μl glycogen as co-precipitant. The precipitate was washed with 80% ethanol and finally eluted in 20ul water. DNA concentration was determined using Qubit dsDNA HS assay kit. The libraries were generated using the Trueseq Nano DNA kit (Illumina) Illumina HiSeq 2500 gds 303173913 GSM3173913 GEO Accession GSM3173913 SRX4159282 GSM3173914 SRP126573 PRJNA422111 SRS3371666 GSM3173914 ChIP-Seq GENOMIC ChIP Reprogramming cells (7.5-10 x 106 cells per sample were collected by trypsinization at day 3 and 6 days post transduction and washed twice with PBS (Gibco). Cells were resuspended in PBS at a density of 5 x 105/mL and then chemically crosslinked by the addition of 1% formaldehyde for 10 min at room temperature with gentle rotation. Crosslinking was stopped by the addition of glycine to a final concentration of 125 mM for 5 min at room temperature. Cells were washed twice with 10 mL cold PBS and lysed in 10 mL Lysis Buffer 1 (150 mM NaCl, 0.5% NP40; 1 mM EDTA, 10% glycerol, 0.25% triton-X100, freshly added complete proteinase inhibitor cocktail in 15 mL tubes at 4°C for 10 min with gentle rocking. The lysate was centrifuged for 10 min at 1350 x g at 4°C. The supernatant was discarded and the pellet was resuspended in 10 mL lysis buffer 2 (10 mM Tris-HCl, pH 8.0, 200 mM NaCl, 1 mM EDTA, 0.5 mM EGTA, protease inhibitor) incubated at 4°C for 10 min. The procedure was repeated using 10 mL lysis buffer 3 (1% SDS, 10 mM EDTA, 50 mM Tris-HCl, pH 8.0, protease inhibitor) and 10 min rocking at RT. Nuclei were collected by centrifugation and washed twice with sonication buffer (10 mM Tris-HCl, pH 8.0, 0.5 mM EDTA, protease inhibitor) and finally suspended in sonication buffer. Samples were sonicated using a Covaris S220 machine with settings to obtain DNA fragments with a length from 150 to 500 bp using microTUBEs (130 μL) for 5 cycles of 30 sec ON and 60 sec OFF using default settings recommended for microTUBEs. 10% Triton-X100 was added and the lysate was centrifuged at high speed (20000 x g for 10 min at 4°C). 1/10 of the supernatant was stored as input control. ChIP was performed in an automated fashion using the IP-Star compacted automated system (Diagenode) using 6 g ChIP-grade antibodies and 50 l protein G Dynabeads (Invitrogen). The coupling time for beads and antibody was 5 hours followed by incubation with lysate for 15 hours at 4°C. Automated wash steps of 10 minutes at 4°C were performed in the following order: low salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 150 mM NaCl) , high salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 500 mM NaCl), LiCl buffer (500 mM LiCl, 50 mM Tris-HCl pH 8.0, 2 mM EDTA, 1% NP-40, 0.5% Na-deoxycholate), TE buffer (10 mM Tris-HCl pH 8.0, 1 mM EDTA) with final elution in 10 mM Tris-HCl pH 8.0, 1 mM EDTA, 1% SDS buffer. The eluted chromatin and input samples were reverse‐crosslinked by overnight incubation at 65°C. Samples were treated with RNaseA (0.2 mg/ml final concentration) at 37°C for 2h followed by proteinase K (0.2 g/ml final conc.) at 55°C for 3 hours. DNA was extracted by phenol:chloroform:isoamyl alcohol (25:24:1) and phase separated using heavy phase-lock tubes (TianGen) by centrifugation at 10000 rpm for 10 min at RT and precipitated with 100% ethanol with 20 μg/μl glycogen as co-precipitant. The precipitate was washed with 80% ethanol and finally eluted in 20ul water. DNA concentration was determined using Qubit dsDNA HS assay kit. The libraries were generated using the Trueseq Nano DNA kit (Illumina) Illumina HiSeq 2500 gds 303173914 GSM3173914 GEO Accession GSM3173914 SRX4159283 GSM3173915 SRP126573 PRJNA422111 SRS3371667 GSM3173915 ChIP-Seq GENOMIC ChIP Reprogramming cells (7.5-10 x 106 cells per sample were collected by trypsinization at day 3 and 6 days post transduction and washed twice with PBS (Gibco). Cells were resuspended in PBS at a density of 5 x 105/mL and then chemically crosslinked by the addition of 1% formaldehyde for 10 min at room temperature with gentle rotation. Crosslinking was stopped by the addition of glycine to a final concentration of 125 mM for 5 min at room temperature. Cells were washed twice with 10 mL cold PBS and lysed in 10 mL Lysis Buffer 1 (150 mM NaCl, 0.5% NP40; 1 mM EDTA, 10% glycerol, 0.25% triton-X100, freshly added complete proteinase inhibitor cocktail in 15 mL tubes at 4°C for 10 min with gentle rocking. The lysate was centrifuged for 10 min at 1350 x g at 4°C. The supernatant was discarded and the pellet was resuspended in 10 mL lysis buffer 2 (10 mM Tris-HCl, pH 8.0, 200 mM NaCl, 1 mM EDTA, 0.5 mM EGTA, protease inhibitor) incubated at 4°C for 10 min. The procedure was repeated using 10 mL lysis buffer 3 (1% SDS, 10 mM EDTA, 50 mM Tris-HCl, pH 8.0, protease inhibitor) and 10 min rocking at RT. Nuclei were collected by centrifugation and washed twice with sonication buffer (10 mM Tris-HCl, pH 8.0, 0.5 mM EDTA, protease inhibitor) and finally suspended in sonication buffer. Samples were sonicated using a Covaris S220 machine with settings to obtain DNA fragments with a length from 150 to 500 bp using microTUBEs (130 μL) for 5 cycles of 30 sec ON and 60 sec OFF using default settings recommended for microTUBEs. 10% Triton-X100 was added and the lysate was centrifuged at high speed (20000 x g for 10 min at 4°C). 1/10 of the supernatant was stored as input control. ChIP was performed in an automated fashion using the IP-Star compacted automated system (Diagenode) using 6 g ChIP-grade antibodies and 50 l protein G Dynabeads (Invitrogen). The coupling time for beads and antibody was 5 hours followed by incubation with lysate for 15 hours at 4°C. Automated wash steps of 10 minutes at 4°C were performed in the following order: low salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 150 mM NaCl) , high salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 500 mM NaCl), LiCl buffer (500 mM LiCl, 50 mM Tris-HCl pH 8.0, 2 mM EDTA, 1% NP-40, 0.5% Na-deoxycholate), TE buffer (10 mM Tris-HCl pH 8.0, 1 mM EDTA) with final elution in 10 mM Tris-HCl pH 8.0, 1 mM EDTA, 1% SDS buffer. The eluted chromatin and input samples were reverse‐crosslinked by overnight incubation at 65°C. Samples were treated with RNaseA (0.2 mg/ml final concentration) at 37°C for 2h followed by proteinase K (0.2 g/ml final conc.) at 55°C for 3 hours. DNA was extracted by phenol:chloroform:isoamyl alcohol (25:24:1) and phase separated using heavy phase-lock tubes (TianGen) by centrifugation at 10000 rpm for 10 min at RT and precipitated with 100% ethanol with 20 μg/μl glycogen as co-precipitant. The precipitate was washed with 80% ethanol and finally eluted in 20ul water. DNA concentration was determined using Qubit dsDNA HS assay kit. The libraries were generated using the Trueseq Nano DNA kit (Illumina) Illumina HiSeq 2500 gds 303173915 GSM3173915 GEO Accession GSM3173915 SRX4159284 GSM3173916 SRP126573 PRJNA422111 SRS3371668 GSM3173916 ChIP-Seq GENOMIC ChIP Reprogramming cells (7.5-10 x 106 cells per sample were collected by trypsinization at day 3 and 6 days post transduction and washed twice with PBS (Gibco). Cells were resuspended in PBS at a density of 5 x 105/mL and then chemically crosslinked by the addition of 1% formaldehyde for 10 min at room temperature with gentle rotation. Crosslinking was stopped by the addition of glycine to a final concentration of 125 mM for 5 min at room temperature. Cells were washed twice with 10 mL cold PBS and lysed in 10 mL Lysis Buffer 1 (150 mM NaCl, 0.5% NP40; 1 mM EDTA, 10% glycerol, 0.25% triton-X100, freshly added complete proteinase inhibitor cocktail in 15 mL tubes at 4°C for 10 min with gentle rocking. The lysate was centrifuged for 10 min at 1350 x g at 4°C. The supernatant was discarded and the pellet was resuspended in 10 mL lysis buffer 2 (10 mM Tris-HCl, pH 8.0, 200 mM NaCl, 1 mM EDTA, 0.5 mM EGTA, protease inhibitor) incubated at 4°C for 10 min. The procedure was repeated using 10 mL lysis buffer 3 (1% SDS, 10 mM EDTA, 50 mM Tris-HCl, pH 8.0, protease inhibitor) and 10 min rocking at RT. Nuclei were collected by centrifugation and washed twice with sonication buffer (10 mM Tris-HCl, pH 8.0, 0.5 mM EDTA, protease inhibitor) and finally suspended in sonication buffer. Samples were sonicated using a Covaris S220 machine with settings to obtain DNA fragments with a length from 150 to 500 bp using microTUBEs (130 μL) for 5 cycles of 30 sec ON and 60 sec OFF using default settings recommended for microTUBEs. 10% Triton-X100 was added and the lysate was centrifuged at high speed (20000 x g for 10 min at 4°C). 1/10 of the supernatant was stored as input control. ChIP was performed in an automated fashion using the IP-Star compacted automated system (Diagenode) using 6 g ChIP-grade antibodies and 50 l protein G Dynabeads (Invitrogen). The coupling time for beads and antibody was 5 hours followed by incubation with lysate for 15 hours at 4°C. Automated wash steps of 10 minutes at 4°C were performed in the following order: low salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 150 mM NaCl) , high salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 500 mM NaCl), LiCl buffer (500 mM LiCl, 50 mM Tris-HCl pH 8.0, 2 mM EDTA, 1% NP-40, 0.5% Na-deoxycholate), TE buffer (10 mM Tris-HCl pH 8.0, 1 mM EDTA) with final elution in 10 mM Tris-HCl pH 8.0, 1 mM EDTA, 1% SDS buffer. The eluted chromatin and input samples were reverse‐crosslinked by overnight incubation at 65°C. Samples were treated with RNaseA (0.2 mg/ml final concentration) at 37°C for 2h followed by proteinase K (0.2 g/ml final conc.) at 55°C for 3 hours. DNA was extracted by phenol:chloroform:isoamyl alcohol (25:24:1) and phase separated using heavy phase-lock tubes (TianGen) by centrifugation at 10000 rpm for 10 min at RT and precipitated with 100% ethanol with 20 μg/μl glycogen as co-precipitant. The precipitate was washed with 80% ethanol and finally eluted in 20ul water. DNA concentration was determined using Qubit dsDNA HS assay kit. The libraries were generated using the Trueseq Nano DNA kit (Illumina) Illumina HiSeq 2500 gds 303173916 GSM3173916 GEO Accession GSM3173916 SRX4159285 GSM3173917 SRP126573 PRJNA422111 SRS3371669 GSM3173917 ChIP-Seq GENOMIC ChIP Reprogramming cells (7.5-10 x 106 cells per sample were collected by trypsinization at day 3 and 6 days post transduction and washed twice with PBS (Gibco). Cells were resuspended in PBS at a density of 5 x 105/mL and then chemically crosslinked by the addition of 1% formaldehyde for 10 min at room temperature with gentle rotation. Crosslinking was stopped by the addition of glycine to a final concentration of 125 mM for 5 min at room temperature. Cells were washed twice with 10 mL cold PBS and lysed in 10 mL Lysis Buffer 1 (150 mM NaCl, 0.5% NP40; 1 mM EDTA, 10% glycerol, 0.25% triton-X100, freshly added complete proteinase inhibitor cocktail in 15 mL tubes at 4°C for 10 min with gentle rocking. The lysate was centrifuged for 10 min at 1350 x g at 4°C. The supernatant was discarded and the pellet was resuspended in 10 mL lysis buffer 2 (10 mM Tris-HCl, pH 8.0, 200 mM NaCl, 1 mM EDTA, 0.5 mM EGTA, protease inhibitor) incubated at 4°C for 10 min. The procedure was repeated using 10 mL lysis buffer 3 (1% SDS, 10 mM EDTA, 50 mM Tris-HCl, pH 8.0, protease inhibitor) and 10 min rocking at RT. Nuclei were collected by centrifugation and washed twice with sonication buffer (10 mM Tris-HCl, pH 8.0, 0.5 mM EDTA, protease inhibitor) and finally suspended in sonication buffer. Samples were sonicated using a Covaris S220 machine with settings to obtain DNA fragments with a length from 150 to 500 bp using microTUBEs (130 μL) for 5 cycles of 30 sec ON and 60 sec OFF using default settings recommended for microTUBEs. 10% Triton-X100 was added and the lysate was centrifuged at high speed (20000 x g for 10 min at 4°C). 1/10 of the supernatant was stored as input control. ChIP was performed in an automated fashion using the IP-Star compacted automated system (Diagenode) using 6 g ChIP-grade antibodies and 50 l protein G Dynabeads (Invitrogen). The coupling time for beads and antibody was 5 hours followed by incubation with lysate for 15 hours at 4°C. Automated wash steps of 10 minutes at 4°C were performed in the following order: low salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 150 mM NaCl) , high salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 500 mM NaCl), LiCl buffer (500 mM LiCl, 50 mM Tris-HCl pH 8.0, 2 mM EDTA, 1% NP-40, 0.5% Na-deoxycholate), TE buffer (10 mM Tris-HCl pH 8.0, 1 mM EDTA) with final elution in 10 mM Tris-HCl pH 8.0, 1 mM EDTA, 1% SDS buffer. The eluted chromatin and input samples were reverse‐crosslinked by overnight incubation at 65°C. Samples were treated with RNaseA (0.2 mg/ml final concentration) at 37°C for 2h followed by proteinase K (0.2 g/ml final conc.) at 55°C for 3 hours. DNA was extracted by phenol:chloroform:isoamyl alcohol (25:24:1) and phase separated using heavy phase-lock tubes (TianGen) by centrifugation at 10000 rpm for 10 min at RT and precipitated with 100% ethanol with 20 μg/μl glycogen as co-precipitant. The precipitate was washed with 80% ethanol and finally eluted in 20ul water. DNA concentration was determined using Qubit dsDNA HS assay kit. The libraries were generated using the Trueseq Nano DNA kit (Illumina) Illumina HiSeq 2500 gds 303173917 GSM3173917 GEO Accession GSM3173917 SRX4159286 GSM3173918 SRP126573 PRJNA422111 SRS3371670 GSM3173918 ChIP-Seq GENOMIC ChIP Reprogramming cells (7.5-10 x 106 cells per sample were collected by trypsinization at day 3 and 6 days post transduction and washed twice with PBS (Gibco). Cells were resuspended in PBS at a density of 5 x 105/mL and then chemically crosslinked by the addition of 1% formaldehyde for 10 min at room temperature with gentle rotation. Crosslinking was stopped by the addition of glycine to a final concentration of 125 mM for 5 min at room temperature. Cells were washed twice with 10 mL cold PBS and lysed in 10 mL Lysis Buffer 1 (150 mM NaCl, 0.5% NP40; 1 mM EDTA, 10% glycerol, 0.25% triton-X100, freshly added complete proteinase inhibitor cocktail in 15 mL tubes at 4°C for 10 min with gentle rocking. The lysate was centrifuged for 10 min at 1350 x g at 4°C. The supernatant was discarded and the pellet was resuspended in 10 mL lysis buffer 2 (10 mM Tris-HCl, pH 8.0, 200 mM NaCl, 1 mM EDTA, 0.5 mM EGTA, protease inhibitor) incubated at 4°C for 10 min. The procedure was repeated using 10 mL lysis buffer 3 (1% SDS, 10 mM EDTA, 50 mM Tris-HCl, pH 8.0, protease inhibitor) and 10 min rocking at RT. Nuclei were collected by centrifugation and washed twice with sonication buffer (10 mM Tris-HCl, pH 8.0, 0.5 mM EDTA, protease inhibitor) and finally suspended in sonication buffer. Samples were sonicated using a Covaris S220 machine with settings to obtain DNA fragments with a length from 150 to 500 bp using microTUBEs (130 μL) for 5 cycles of 30 sec ON and 60 sec OFF using default settings recommended for microTUBEs. 10% Triton-X100 was added and the lysate was centrifuged at high speed (20000 x g for 10 min at 4°C). 1/10 of the supernatant was stored as input control. ChIP was performed in an automated fashion using the IP-Star compacted automated system (Diagenode) using 6 g ChIP-grade antibodies and 50 l protein G Dynabeads (Invitrogen). The coupling time for beads and antibody was 5 hours followed by incubation with lysate for 15 hours at 4°C. Automated wash steps of 10 minutes at 4°C were performed in the following order: low salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 150 mM NaCl) , high salt buffer (20 mM Tris-HCl pH 8.0, 0.1% SDS 1% TritonX-100, 2 mM EDTA, 500 mM NaCl), LiCl buffer (500 mM LiCl, 50 mM Tris-HCl pH 8.0, 2 mM EDTA, 1% NP-40, 0.5% Na-deoxycholate), TE buffer (10 mM Tris-HCl pH 8.0, 1 mM EDTA) with final elution in 10 mM Tris-HCl pH 8.0, 1 mM EDTA, 1% SDS buffer. The eluted chromatin and input samples were reverse‐crosslinked by overnight incubation at 65°C. Samples were treated with RNaseA (0.2 mg/ml final concentration) at 37°C for 2h followed by proteinase K (0.2 g/ml final conc.) at 55°C for 3 hours. DNA was extracted by phenol:chloroform:isoamyl alcohol (25:24:1) and phase separated using heavy phase-lock tubes (TianGen) by centrifugation at 10000 rpm for 10 min at RT and precipitated with 100% ethanol with 20 μg/μl glycogen as co-precipitant. The precipitate was washed with 80% ethanol and finally eluted in 20ul water. DNA concentration was determined using Qubit dsDNA HS assay kit. The libraries were generated using the Trueseq Nano DNA kit (Illumina) Illumina HiSeq 2500 gds 303173918 GSM3173918 GEO Accession GSM3173918 SRX4161221 GSM3175206 SRP126573 PRJNA422111 SRS3373587 GSM3175206 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175206 GSM3175206 GEO Accession GSM3175206 SRX4161222 GSM3175207 SRP126573 PRJNA422111 SRS3373589 GSM3175207 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175207 GSM3175207 GEO Accession GSM3175207 SRX4161223 GSM3175208 SRP126573 PRJNA422111 SRS3373588 GSM3175208 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175208 GSM3175208 GEO Accession GSM3175208 SRX4161224 GSM3175209 SRP126573 PRJNA422111 SRS3373590 GSM3175209 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175209 GSM3175209 GEO Accession GSM3175209 SRX4161225 GSM3175210 SRP126573 PRJNA422111 SRS3373591 GSM3175210 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175210 GSM3175210 GEO Accession GSM3175210 SRX4161226 GSM3175211 SRP126573 PRJNA422111 SRS3373592 GSM3175211 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175211 GSM3175211 GEO Accession GSM3175211 SRX4161227 GSM3175212 SRP126573 PRJNA422111 SRS3373593 GSM3175212 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175212 GSM3175212 GEO Accession GSM3175212 SRX4161228 GSM3175213 SRP126573 PRJNA422111 SRS3373594 GSM3175213 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175213 GSM3175213 GEO Accession GSM3175213 SRX4161229 GSM3175214 SRP126573 PRJNA422111 SRS3373595 GSM3175214 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175214 GSM3175214 GEO Accession GSM3175214 SRX4161230 GSM3175215 SRP126573 PRJNA422111 SRS3373597 GSM3175215 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175215 GSM3175215 GEO Accession GSM3175215 SRX4161231 GSM3175216 SRP126573 PRJNA422111 SRS3373596 GSM3175216 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175216 GSM3175216 GEO Accession GSM3175216 SRX4161232 GSM3175217 SRP126573 PRJNA422111 SRS3373598 GSM3175217 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175217 GSM3175217 GEO Accession GSM3175217 SRX4161233 GSM3175218 SRP126573 PRJNA422111 SRS3373599 GSM3175218 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175218 GSM3175218 GEO Accession GSM3175218 SRX4161234 GSM3175219 SRP126573 PRJNA422111 SRS3373601 GSM3175219 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175219 GSM3175219 GEO Accession GSM3175219 SRX4161235 GSM3175220 SRP126573 PRJNA422111 SRS3373600 GSM3175220 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175220 GSM3175220 GEO Accession GSM3175220 SRX4161236 GSM3175221 SRP126573 PRJNA422111 SRS3373602 GSM3175221 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175221 GSM3175221 GEO Accession GSM3175221 SRX4161237 GSM3175222 SRP126573 PRJNA422111 SRS3373603 GSM3175222 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175222 GSM3175222 GEO Accession GSM3175222 SRX4161238 GSM3175223 SRP126573 PRJNA422111 SRS3373604 GSM3175223 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175223 GSM3175223 GEO Accession GSM3175223 SRX4161239 GSM3175224 SRP126573 PRJNA422111 SRS3373605 GSM3175224 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175224 GSM3175224 GEO Accession GSM3175224 SRX4161240 GSM3175225 SRP126573 PRJNA422111 SRS3373606 GSM3175225 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175225 GSM3175225 GEO Accession GSM3175225 SRX4161241 GSM3175226 SRP126573 PRJNA422111 SRS3373607 GSM3175226 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175226 GSM3175226 GEO Accession GSM3175226 SRX4161242 GSM3175227 SRP126573 PRJNA422111 SRS3373608 GSM3175227 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175227 GSM3175227 GEO Accession GSM3175227 SRX4161243 GSM3175228 SRP126573 PRJNA422111 SRS3373610 GSM3175228 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175228 GSM3175228 GEO Accession GSM3175228 SRX4161244 GSM3175229 SRP126573 PRJNA422111 SRS3373609 GSM3175229 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175229 GSM3175229 GEO Accession GSM3175229 SRX4161245 GSM3175230 SRP126573 PRJNA422111 SRS3373611 GSM3175230 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175230 GSM3175230 GEO Accession GSM3175230 SRX4161246 GSM3175231 SRP126573 PRJNA422111 SRS3373612 GSM3175231 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175231 GSM3175231 GEO Accession GSM3175231 SRX4161247 GSM3175232 SRP126573 PRJNA422111 SRS3373615 GSM3175232 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175232 GSM3175232 GEO Accession GSM3175232 SRX4161248 GSM3175233 SRP126573 PRJNA422111 SRS3373613 GSM3175233 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175233 GSM3175233 GEO Accession GSM3175233 SRX4161249 GSM3175234 SRP126573 PRJNA422111 SRS3373614 GSM3175234 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175234 GSM3175234 GEO Accession GSM3175234 SRX4161250 GSM3175235 SRP126573 PRJNA422111 SRS3373616 GSM3175235 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175235 GSM3175235 GEO Accession GSM3175235 SRX4161251 GSM3175236 SRP126573 PRJNA422111 SRS3373617 GSM3175236 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175236 GSM3175236 GEO Accession GSM3175236 SRX4161252 GSM3175237 SRP126573 PRJNA422111 SRS3373618 GSM3175237 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175237 GSM3175237 GEO Accession GSM3175237 SRX4161253 GSM3175238 SRP126573 PRJNA422111 SRS3373619 GSM3175238 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175238 GSM3175238 GEO Accession GSM3175238 SRX4161254 GSM3175239 SRP126573 PRJNA422111 SRS3373620 GSM3175239 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175239 GSM3175239 GEO Accession GSM3175239 SRX4161255 GSM3175240 SRP126573 PRJNA422111 SRS3373622 GSM3175240 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175240 GSM3175240 GEO Accession GSM3175240 SRX4161256 GSM3175241 SRP126573 PRJNA422111 SRS3373621 GSM3175241 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was prepared with TRIzol TruSeq Nano RNA sample prep kit (Illumina) was used for library constructions. Illumina HiSeq 2500 gds 303175241 GSM3175241 GEO Accession GSM3175241