SRX3511086 GSM2902624 SRP127541 SRS2791624 GSM2902624 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902624 GSM2902624 GEO Accession GSM2902624 SRX3511087 GSM2902625 SRP127541 SRS2791620 GSM2902625 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902625 GSM2902625 GEO Accession GSM2902625 SRX3511088 GSM2902626 SRP127541 SRS2791622 GSM2902626 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902626 GSM2902626 GEO Accession GSM2902626 SRX3511089 GSM2902627 SRP127541 SRS2791621 GSM2902627 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902627 GSM2902627 GEO Accession GSM2902627 SRX3511090 GSM2902628 SRP127541 SRS2791634 GSM2902628 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902628 GSM2902628 GEO Accession GSM2902628 SRX3511091 GSM2902629 SRP127541 SRS2791632 GSM2902629 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902629 GSM2902629 GEO Accession GSM2902629 SRX3511092 GSM2902630 SRP127541 SRS2791625 GSM2902630 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902630 GSM2902630 GEO Accession GSM2902630 SRX3511093 GSM2902631 SRP127541 SRS2791623 GSM2902631 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902631 GSM2902631 GEO Accession GSM2902631 SRX3511094 GSM2902632 SRP127541 SRS2791626 GSM2902632 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902632 GSM2902632 GEO Accession GSM2902632 SRX3511095 GSM2902633 SRP127541 SRS2791628 GSM2902633 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902633 GSM2902633 GEO Accession GSM2902633 SRX3511096 GSM2902634 SRP127541 SRS2791627 GSM2902634 ATAC-seq GENOMIC other ATAC-seq was performed on 100000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. In addition, the centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902634 GSM2902634 GEO Accession GSM2902634 SRX3511097 GSM2902635 SRP127541 SRS2791629 GSM2902635 ATAC-seq GENOMIC other ATAC-seq was performed on 50000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. Cell lysis was performed via a 10 minute centrifugation in lysis buffer, as described in the original protocol (Buenrostro et al., 2013). Illumina HiSeq 2000 gds 302902635 GSM2902635 GEO Accession GSM2902635 SRX3511098 GSM2902636 SRP127541 SRS2791639 GSM2902636 ATAC-seq GENOMIC other ATAC-seq was performed on 50000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. Cell lysis was performed via a 5 minute centrifugation in lysis buffer, as opposed to the 10 minutes described in the original protocol (Buenrostro et al., 2013). Illumina HiSeq 2000 gds 302902636 GSM2902636 GEO Accession GSM2902636 SRX3511099 GSM2902637 SRP127541 SRS2791631 GSM2902637 ATAC-seq GENOMIC other ATAC-seq was performed on 50000 cells, following the published protocol (Buenrostro et al., 2013) but increasing transposition time from 30 minutes to 1 hour. The centrifugation in lysis buffer step was omitted, and the cell pellets were taken directly to the transposition reaction. Illumina HiSeq 2000 gds 302902637 GSM2902637 GEO Accession GSM2902637 SRX3511100 GSM2902638 SRP127541 SRS2791630 GSM2902638 DNase-Hypersensitivity GENOMIC DNase DNase-seq was conducted on 50 million cells as previously described (Song and Crawford, 2010), with the minor modification of using 5' phosphorylated oligo 1b. Samples digested with 12U, 4U and 1.2U total DNase I were pooled. Illumina HiSeq 2500 gds 302902638 GSM2902638 GEO Accession GSM2902638 SRX3511101 GSM2902639 SRP127541 SRS2791633 GSM2902639 DNase-Hypersensitivity GENOMIC DNase DNase-seq was conducted on 50 million cells as previously described (Song and Crawford, 2010), with the minor modification of using 5' phosphorylated oligo 1b. Samples digested with 12U, 4U and 1.2U total DNase I were pooled. Illumina HiSeq 2500 gds 302902639 GSM2902639 GEO Accession GSM2902639