SRX3540918 GSM2915244 SRP128557 SRS2818374 GSM2915244 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915244 GSM2915244 GEO Accession GSM2915244 SRX3540919 GSM2915245 SRP128557 SRS2818323 GSM2915245 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915245 GSM2915245 GEO Accession GSM2915245 SRX3540920 GSM2915246 SRP128557 SRS2818430 GSM2915246 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915246 GSM2915246 GEO Accession GSM2915246 SRX3540921 GSM2915247 SRP128557 SRS2818310 GSM2915247 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915247 GSM2915247 GEO Accession GSM2915247 SRX3540922 GSM2915248 SRP128557 SRS2818321 GSM2915248 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915248 GSM2915248 GEO Accession GSM2915248 SRX3540923 GSM2915249 SRP128557 SRS2818311 GSM2915249 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915249 GSM2915249 GEO Accession GSM2915249 SRX3540924 GSM2915250 SRP128557 SRS2818380 GSM2915250 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915250 GSM2915250 GEO Accession GSM2915250 SRX3540925 GSM2915251 SRP128557 SRS2818316 GSM2915251 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915251 GSM2915251 GEO Accession GSM2915251 SRX3540926 GSM2915252 SRP128557 SRS2818312 GSM2915252 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915252 GSM2915252 GEO Accession GSM2915252 SRX3540927 GSM2915253 SRP128557 SRS2818385 GSM2915253 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915253 GSM2915253 GEO Accession GSM2915253 SRX3540928 GSM2915254 SRP128557 SRS2818313 GSM2915254 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915254 GSM2915254 GEO Accession GSM2915254 SRX3540929 GSM2915255 SRP128557 SRS2818319 GSM2915255 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915255 GSM2915255 GEO Accession GSM2915255 SRX3540930 GSM2915256 SRP128557 SRS2818318 GSM2915256 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915256 GSM2915256 GEO Accession GSM2915256 SRX3540931 GSM2915257 SRP128557 SRS2818317 GSM2915257 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915257 GSM2915257 GEO Accession GSM2915257 SRX3540932 GSM2915258 SRP128557 SRS2818387 GSM2915258 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915258 GSM2915258 GEO Accession GSM2915258 SRX3540933 GSM2915259 SRP128557 SRS2818322 GSM2915259 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915259 GSM2915259 GEO Accession GSM2915259 SRX3540934 GSM2915260 SRP128557 SRS2818373 GSM2915260 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915260 GSM2915260 GEO Accession GSM2915260 SRX3540935 GSM2915261 SRP128557 SRS2818326 GSM2915261 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915261 GSM2915261 GEO Accession GSM2915261 SRX3540936 GSM2915262 SRP128557 SRS2818306 GSM2915262 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915262 GSM2915262 GEO Accession GSM2915262 SRX3540937 GSM2915263 SRP128557 SRS2818309 GSM2915263 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915263 GSM2915263 GEO Accession GSM2915263 SRX3540938 GSM2915264 SRP128557 SRS2818425 GSM2915264 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915264 GSM2915264 GEO Accession GSM2915264 SRX3540939 GSM2915265 SRP128557 SRS2818405 GSM2915265 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915265 GSM2915265 GEO Accession GSM2915265 SRX3540940 GSM2915266 SRP128557 SRS2818314 GSM2915266 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915266 GSM2915266 GEO Accession GSM2915266 SRX3540941 GSM2915267 SRP128557 SRS2818375 GSM2915267 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915267 GSM2915267 GEO Accession GSM2915267 SRX3540942 GSM2915268 SRP128557 SRS2818320 GSM2915268 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915268 GSM2915268 GEO Accession GSM2915268 SRX3540943 GSM2915269 SRP128557 SRS2818131 GSM2915269 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915269 GSM2915269 GEO Accession GSM2915269 SRX3540944 GSM2915270 SRP128557 SRS2818132 GSM2915270 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915270 GSM2915270 GEO Accession GSM2915270 SRX3540945 GSM2915271 SRP128557 SRS2818133 GSM2915271 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915271 GSM2915271 GEO Accession GSM2915271 SRX3540946 GSM2915272 SRP128557 SRS2818248 GSM2915272 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915272 GSM2915272 GEO Accession GSM2915272 SRX3540947 GSM2915273 SRP128557 SRS2818136 GSM2915273 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915273 GSM2915273 GEO Accession GSM2915273 SRX3540948 GSM2915274 SRP128557 SRS2818130 GSM2915274 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915274 GSM2915274 GEO Accession GSM2915274 SRX3540949 GSM2915275 SRP128557 SRS2818134 GSM2915275 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915275 GSM2915275 GEO Accession GSM2915275 SRX3540950 GSM2915276 SRP128557 SRS2818135 GSM2915276 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915276 GSM2915276 GEO Accession GSM2915276 SRX3540951 GSM2915277 SRP128557 SRS2818138 GSM2915277 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915277 GSM2915277 GEO Accession GSM2915277 SRX3540952 GSM2915278 SRP128557 SRS2818139 GSM2915278 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915278 GSM2915278 GEO Accession GSM2915278 SRX3540953 GSM2915279 SRP128557 SRS2818137 GSM2915279 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915279 GSM2915279 GEO Accession GSM2915279 SRX3540954 GSM2915280 SRP128557 SRS2818142 GSM2915280 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915280 GSM2915280 GEO Accession GSM2915280 SRX3540955 GSM2915281 SRP128557 SRS2818140 GSM2915281 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915281 GSM2915281 GEO Accession GSM2915281 SRX3540956 GSM2915282 SRP128557 SRS2818141 GSM2915282 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915282 GSM2915282 GEO Accession GSM2915282 SRX3540957 GSM2915283 SRP128557 SRS2818143 GSM2915283 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915283 GSM2915283 GEO Accession GSM2915283 SRX3540958 GSM2915284 SRP128557 SRS2818145 GSM2915284 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915284 GSM2915284 GEO Accession GSM2915284 SRX3540959 GSM2915285 SRP128557 SRS2818144 GSM2915285 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915285 GSM2915285 GEO Accession GSM2915285 SRX3540960 GSM2915286 SRP128557 SRS2818146 GSM2915286 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915286 GSM2915286 GEO Accession GSM2915286 SRX3540961 GSM2915287 SRP128557 SRS2818147 GSM2915287 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915287 GSM2915287 GEO Accession GSM2915287 SRX3540962 GSM2915288 SRP128557 SRS2818148 GSM2915288 miRNA-Seq TRANSCRIPTOMIC size fractionation Whole blood RNA was isolated from PAXgene tubes using microRNA isolation kit (Qiagen) using TRIsol LS (Invitrogen) following manufacturer's instructions. RNA library preparation was performed following the NEB NEBNext Multiplex Small RNA Library Preparation protocol. Briefly, 400 ng of total RNA was used as the input material. The 3' SR Adapter was ligated to the small RNA, followed by RT primer hybridization to the 3' SR adapter and then the 5' SR Adapter was ligated to the opposite end (this strategy prevents formation of adapter-dimers). First stranded synthesis was then performed off the RT primer and the library was enriched by PCR using the following conditions: initial denaturation at 94oC for 30 seconds, followed by 15 cycles of 94oC for 15 seconds, 62oC for 30 seconds and 70oC for 15 seconds, and finally an extension step for 5 minutes at 70oC; at the amplification step, each sample were amplified with a different barcoded adapters to allow for multiplex sequencing. One ul of the final Small RNA libraries was loaded on a Bioanalyzer 2100 DNA High Sensitivity chip (Agilent Technologies) to check for size and libraries were quantified by qPCR using the Kapa Library Quantification Illumina/ABI Prism Kit protocol (KAPA Biosystems). Libraries were pooled in equimolar quantities and sequenced on a High Throughput Run Mode flowcell with the V4 sequencing chemistry on an Illumina HiSeq 2500 platform following Illumina's recommended protocol to generate single-end reads of 50-bases in length. Illumina HiSeq 2500 gds 302915288 GSM2915288 GEO Accession GSM2915288