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    <TITLE>GSM3072491: S1_L001: Control rep1; Escherichia coli str. K-12 substr. MG1655; RNA-Seq</TITLE>
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      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
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      <PRIMARY_ID>SRX3867273</PRIMARY_ID>
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    <TITLE>GSM3072492: S1_L002: Control rep2; Escherichia coli str. K-12 substr. MG1655; RNA-Seq</TITLE>
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        <PRIMARY_ID>SRP136815</PRIMARY_ID>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated using Zymo RNA isolation kit (Zymo Research, Irvine, CA) by following the manufacturer's suggested protocol. Total RNA was quantified by Qubit and the RNA integrity (RIN) was assessed by Agilent 2200 TapeStation.  Ribo-Zero rRNA removal Kit (Illumina, San Diego, CA) was used to remove ribosomal RNA from 1 µg of total RNA sample by following the protocol supplied in the kit. cDNA was synthesized by reverse transcription and amplified to generate library using ScriptSeq Complete Kit (Epicenter, Madison, WI) and thermal cycler by following the library preparation protocol provided by the manufacturer. Libraries were sequenced on an Illumina NextSeq500 with 2x75bp reads on a Mid Output Sequencing Flow Cell.</LIBRARY_CONSTRUCTION_PROTOCOL>
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      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
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      <PRIMARY_ID>SRX3867274</PRIMARY_ID>
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    <TITLE>GSM3072493: S1_L003: Control rep3; Escherichia coli str. K-12 substr. MG1655; RNA-Seq</TITLE>
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        <PRIMARY_ID>SRP136815</PRIMARY_ID>
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        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated using Zymo RNA isolation kit (Zymo Research, Irvine, CA) by following the manufacturer's suggested protocol. Total RNA was quantified by Qubit and the RNA integrity (RIN) was assessed by Agilent 2200 TapeStation.  Ribo-Zero rRNA removal Kit (Illumina, San Diego, CA) was used to remove ribosomal RNA from 1 µg of total RNA sample by following the protocol supplied in the kit. cDNA was synthesized by reverse transcription and amplified to generate library using ScriptSeq Complete Kit (Epicenter, Madison, WI) and thermal cycler by following the library preparation protocol provided by the manufacturer. Libraries were sequenced on an Illumina NextSeq500 with 2x75bp reads on a Mid Output Sequencing Flow Cell.</LIBRARY_CONSTRUCTION_PROTOCOL>
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      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
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      <PRIMARY_ID>SRX3867275</PRIMARY_ID>
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    <TITLE>GSM3072494: S1_L004: Control rep4; Escherichia coli str. K-12 substr. MG1655; RNA-Seq</TITLE>
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        <PRIMARY_ID>SRP136815</PRIMARY_ID>
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        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated using Zymo RNA isolation kit (Zymo Research, Irvine, CA) by following the manufacturer's suggested protocol. Total RNA was quantified by Qubit and the RNA integrity (RIN) was assessed by Agilent 2200 TapeStation.  Ribo-Zero rRNA removal Kit (Illumina, San Diego, CA) was used to remove ribosomal RNA from 1 µg of total RNA sample by following the protocol supplied in the kit. cDNA was synthesized by reverse transcription and amplified to generate library using ScriptSeq Complete Kit (Epicenter, Madison, WI) and thermal cycler by following the library preparation protocol provided by the manufacturer. Libraries were sequenced on an Illumina NextSeq500 with 2x75bp reads on a Mid Output Sequencing Flow Cell.</LIBRARY_CONSTRUCTION_PROTOCOL>
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      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
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      <PRIMARY_ID>SRX3867276</PRIMARY_ID>
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    <TITLE>GSM3072495: S2_L001: ET2DA rep1; Escherichia coli str. K-12 substr. MG1655; RNA-Seq</TITLE>
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        <PRIMARY_ID>SRP136815</PRIMARY_ID>
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          <PRIMARY_ID>SRS3110349</PRIMARY_ID>
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        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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          <PAIRED/>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated using Zymo RNA isolation kit (Zymo Research, Irvine, CA) by following the manufacturer's suggested protocol. Total RNA was quantified by Qubit and the RNA integrity (RIN) was assessed by Agilent 2200 TapeStation.  Ribo-Zero rRNA removal Kit (Illumina, San Diego, CA) was used to remove ribosomal RNA from 1 µg of total RNA sample by following the protocol supplied in the kit. cDNA was synthesized by reverse transcription and amplified to generate library using ScriptSeq Complete Kit (Epicenter, Madison, WI) and thermal cycler by following the library preparation protocol provided by the manufacturer. Libraries were sequenced on an Illumina NextSeq500 with 2x75bp reads on a Mid Output Sequencing Flow Cell.</LIBRARY_CONSTRUCTION_PROTOCOL>
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    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
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      <PRIMARY_ID>SRX3867277</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3072496</SUBMITTER_ID>
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    <TITLE>GSM3072496: S2_L002: ET2DA rep2; Escherichia coli str. K-12 substr. MG1655; RNA-Seq</TITLE>
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        <PRIMARY_ID>SRP136815</PRIMARY_ID>
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          <PRIMARY_ID>SRS3110348</PRIMARY_ID>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated using Zymo RNA isolation kit (Zymo Research, Irvine, CA) by following the manufacturer's suggested protocol. Total RNA was quantified by Qubit and the RNA integrity (RIN) was assessed by Agilent 2200 TapeStation.  Ribo-Zero rRNA removal Kit (Illumina, San Diego, CA) was used to remove ribosomal RNA from 1 µg of total RNA sample by following the protocol supplied in the kit. cDNA was synthesized by reverse transcription and amplified to generate library using ScriptSeq Complete Kit (Epicenter, Madison, WI) and thermal cycler by following the library preparation protocol provided by the manufacturer. Libraries were sequenced on an Illumina NextSeq500 with 2x75bp reads on a Mid Output Sequencing Flow Cell.</LIBRARY_CONSTRUCTION_PROTOCOL>
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      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
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      <PRIMARY_ID>SRX3867278</PRIMARY_ID>
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    <TITLE>GSM3072497: S2_L003: ET2DA rep3; Escherichia coli str. K-12 substr. MG1655; RNA-Seq</TITLE>
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      <IDENTIFIERS>
        <PRIMARY_ID>SRP136815</PRIMARY_ID>
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      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3110350">
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          <PRIMARY_ID>SRS3110350</PRIMARY_ID>
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        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated using Zymo RNA isolation kit (Zymo Research, Irvine, CA) by following the manufacturer's suggested protocol. Total RNA was quantified by Qubit and the RNA integrity (RIN) was assessed by Agilent 2200 TapeStation.  Ribo-Zero rRNA removal Kit (Illumina, San Diego, CA) was used to remove ribosomal RNA from 1 µg of total RNA sample by following the protocol supplied in the kit. cDNA was synthesized by reverse transcription and amplified to generate library using ScriptSeq Complete Kit (Epicenter, Madison, WI) and thermal cycler by following the library preparation protocol provided by the manufacturer. Libraries were sequenced on an Illumina NextSeq500 with 2x75bp reads on a Mid Output Sequencing Flow Cell.</LIBRARY_CONSTRUCTION_PROTOCOL>
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      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
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      <PRIMARY_ID>SRX3867279</PRIMARY_ID>
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    <TITLE>GSM3072498: S2_L004: ET2DA rep4; Escherichia coli str. K-12 substr. MG1655; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP136815" refname="GSE112545">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP136815</PRIMARY_ID>
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      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3110351">
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          <PRIMARY_ID>SRS3110351</PRIMARY_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated using Zymo RNA isolation kit (Zymo Research, Irvine, CA) by following the manufacturer's suggested protocol. Total RNA was quantified by Qubit and the RNA integrity (RIN) was assessed by Agilent 2200 TapeStation.  Ribo-Zero rRNA removal Kit (Illumina, San Diego, CA) was used to remove ribosomal RNA from 1 µg of total RNA sample by following the protocol supplied in the kit. cDNA was synthesized by reverse transcription and amplified to generate library using ScriptSeq Complete Kit (Epicenter, Madison, WI) and thermal cycler by following the library preparation protocol provided by the manufacturer. Libraries were sequenced on an Illumina NextSeq500 with 2x75bp reads on a Mid Output Sequencing Flow Cell.</LIBRARY_CONSTRUCTION_PROTOCOL>
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    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
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        <XREF_LINK>
          <DB>gds</DB>
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          <LABEL>GSM3072498</LABEL>
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