SRP153912 PRJNA481326 GSE117159 Accurate classification of BRCA1 variants with saturation genome editing We describe the use of saturation genome editing to make and measure the effect of BRCA1 variants on protein function and splicing. We find the results accurately predict the clinical effects of variants. Overall design: Saturation genome editing of the BRCA1 exons encoding the RING and BRCT domain. GSE117159 pubmed 30209399