SRX4394582 GSM3272763 SRP153920 SRS3549833 GSM3272763 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).   Purified DNA (~1 µg) were used for End-repair and dA-tailing and adaptor ligation (NEBNext Ultra II DNA Library Prep Kit) following manufacture's instruction.  The DNA was then processed second adaptor ligation.   After quality check, the DNA samples were purified with HighPrep PCR beads, and ligated DNA were PCR amplified by NEBNext Ultra II PCR Master Mix with NEBNext Multiplex Oligos for Illumina (New England Biolabs).  The PCR libraries were purified with HighPrep PCR beads.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272763 GSM3272763 GEO Accession GSM3272763 SRX4394583 GSM3272764 SRP153920 SRS3549834 GSM3272764 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).   Purified DNA (~1 µg) were used for End-repair and dA-tailing and adaptor ligation (NEBNext Ultra II DNA Library Prep Kit) following manufacture's instruction.  The DNA was then processed second adaptor ligation.   After quality check, the DNA samples were purified with HighPrep PCR beads, and ligated DNA were PCR amplified by NEBNext Ultra II PCR Master Mix with NEBNext Multiplex Oligos for Illumina (New England Biolabs).  The PCR libraries were purified with HighPrep PCR beads.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272764 GSM3272764 GEO Accession GSM3272764 SRX4394584 GSM3272765 SRP153920 SRS3549835 GSM3272765 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).   Purified DNA (~1 µg) were used for End-repair and dA-tailing and adaptor ligation (NEBNext Ultra II DNA Library Prep Kit) following manufacture's instruction.  The DNA was then processed second adaptor ligation.   After quality check, the DNA samples were purified with HighPrep PCR beads, and ligated DNA were PCR amplified by NEBNext Ultra II PCR Master Mix with NEBNext Multiplex Oligos for Illumina (New England Biolabs).  The PCR libraries were purified with HighPrep PCR beads.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272765 GSM3272765 GEO Accession GSM3272765 SRX4394585 GSM3272766 SRP153920 SRS3549836 GSM3272766 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).   Purified DNA (~1 µg) were used for End-repair and dA-tailing and adaptor ligation (NEBNext Ultra II DNA Library Prep Kit) following manufacture's instruction.  The DNA was then processed second adaptor ligation.   After quality check, the DNA samples were purified with HighPrep PCR beads, and ligated DNA were PCR amplified by NEBNext Ultra II PCR Master Mix with NEBNext Multiplex Oligos for Illumina (New England Biolabs).  The PCR libraries were purified with HighPrep PCR beads.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272766 GSM3272766 GEO Accession GSM3272766 SRX4394586 GSM3272767 SRP153920 SRS3549837 GSM3272767 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).   Purified DNA (~1 µg) were used for End-repair and dA-tailing and adaptor ligation (NEBNext Ultra II DNA Library Prep Kit) following manufacture's instruction.  The DNA was then processed second adaptor ligation.   After quality check, the DNA samples were purified with HighPrep PCR beads, and ligated DNA were PCR amplified by NEBNext Ultra II PCR Master Mix with NEBNext Multiplex Oligos for Illumina (New England Biolabs).  The PCR libraries were purified with HighPrep PCR beads.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272767 GSM3272767 GEO Accession GSM3272767 SRX4394587 GSM3272768 SRP153920 SRS3549838 GSM3272768 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).   Purified DNA (~1 µg) were used for End-repair and dA-tailing and adaptor ligation (NEBNext Ultra II DNA Library Prep Kit) following manufacture's instruction.  The DNA was then processed second adaptor ligation.   After quality check, the DNA samples were purified with HighPrep PCR beads, and ligated DNA were PCR amplified by NEBNext Ultra II PCR Master Mix with NEBNext Multiplex Oligos for Illumina (New England Biolabs).  The PCR libraries were purified with HighPrep PCR beads.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272768 GSM3272768 GEO Accession GSM3272768 SRX4394588 GSM3272769 SRP153920 SRS3549839 GSM3272769 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).   Purified DNA (~1 µg) were used for End-repair and dA-tailing and adaptor ligation (NEBNext Ultra II DNA Library Prep Kit) following manufacture's instruction.  The DNA was then processed second adaptor ligation.   After quality check, the DNA samples were purified with HighPrep PCR beads, and ligated DNA were PCR amplified by NEBNext Ultra II PCR Master Mix with NEBNext Multiplex Oligos for Illumina (New England Biolabs).  The PCR libraries were purified with HighPrep PCR beads.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272769 GSM3272769 GEO Accession GSM3272769 SRX4394589 GSM3272770 SRP153920 SRS3549840 GSM3272770 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).   Purified DNA (~1 µg) were used for End-repair and dA-tailing and adaptor ligation (NEBNext Ultra II DNA Library Prep Kit) following manufacture's instruction.  The DNA was then processed second adaptor ligation.   After quality check, the DNA samples were purified with HighPrep PCR beads, and ligated DNA were PCR amplified by NEBNext Ultra II PCR Master Mix with NEBNext Multiplex Oligos for Illumina (New England Biolabs).  The PCR libraries were purified with HighPrep PCR beads.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272770 GSM3272770 GEO Accession GSM3272770 SRX4394590 GSM3272771 SRP153920 SRS3549841 GSM3272771 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).  Four hours after injecting cisplatin or saline solution (control group), the mice were sacrificed by carbon dioxide exposure, the kidneys, liver, lung and spleen were removed and washed extensively with cold phosphate buffered saline (PBS), and then homogenized them. The chromatin fraction was then pelleted. The supernatants (containing low molecular DNA-protein fragments) were harvested and immunoprecipitated (IP) with anti-TFIIH (p89 antibody (G-10), and p62 antibody (H-10), Santa-Cruz Biotechnology). The eluted DNA were isolated using phenol-chloroform and ethanol precipitation. The low-molecular excision products were immunoprecipitated with anti-TFIIH (p89 antibody and p62 antibody), and ligated to adaptors on the both ends.  After second round immunoprecipitated with cisplatin-specific anti-body, the Pt-DNA adducts were reversed by incubating in NaCN (200 mM) over-night.  Then the damage free DNAs were amplified by PCR to get XR-seq libraries and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272771 GSM3272771 GEO Accession GSM3272771 SRX4394591 GSM3272772 SRP153920 SRS3549842 GSM3272772 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).  Four hours after injecting cisplatin or saline solution (control group), the mice were sacrificed by carbon dioxide exposure, the kidneys, liver, lung and spleen were removed and washed extensively with cold phosphate buffered saline (PBS), and then homogenized them. The chromatin fraction was then pelleted. The supernatants (containing low molecular DNA-protein fragments) were harvested and immunoprecipitated (IP) with anti-TFIIH (p89 antibody (G-10), and p62 antibody (H-10), Santa-Cruz Biotechnology). The eluted DNA were isolated using phenol-chloroform and ethanol precipitation. The low-molecular excision products were immunoprecipitated with anti-TFIIH (p89 antibody and p62 antibody), and ligated to adaptors on the both ends.  After second round immunoprecipitated with cisplatin-specific anti-body, the Pt-DNA adducts were reversed by incubating in NaCN (200 mM) over-night.  Then the damage free DNAs were amplified by PCR to get XR-seq libraries and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272772 GSM3272772 GEO Accession GSM3272772 SRX4394592 GSM3272773 SRP153920 SRS3549843 GSM3272773 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).  Four hours after injecting cisplatin or saline solution (control group), the mice were sacrificed by carbon dioxide exposure, the kidneys, liver, lung and spleen were removed and washed extensively with cold phosphate buffered saline (PBS), and then homogenized them. The chromatin fraction was then pelleted. The supernatants (containing low molecular DNA-protein fragments) were harvested and immunoprecipitated (IP) with anti-TFIIH (p89 antibody (G-10), and p62 antibody (H-10), Santa-Cruz Biotechnology). The eluted DNA were isolated using phenol-chloroform and ethanol precipitation. The low-molecular excision products were immunoprecipitated with anti-TFIIH (p89 antibody and p62 antibody), and ligated to adaptors on the both ends.  After second round immunoprecipitated with cisplatin-specific anti-body, the Pt-DNA adducts were reversed by incubating in NaCN (200 mM) over-night.  Then the damage free DNAs were amplified by PCR to get XR-seq libraries and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272773 GSM3272773 GEO Accession GSM3272773 SRX4394593 GSM3272774 SRP153920 SRS3549844 GSM3272774 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).  Four hours after injecting cisplatin or saline solution (control group), the mice were sacrificed by carbon dioxide exposure, the kidneys, liver, lung and spleen were removed and washed extensively with cold phosphate buffered saline (PBS), and then homogenized them. The chromatin fraction was then pelleted. The supernatants (containing low molecular DNA-protein fragments) were harvested and immunoprecipitated (IP) with anti-TFIIH (p89 antibody (G-10), and p62 antibody (H-10), Santa-Cruz Biotechnology). The eluted DNA were isolated using phenol-chloroform and ethanol precipitation. The low-molecular excision products were immunoprecipitated with anti-TFIIH (p89 antibody and p62 antibody), and ligated to adaptors on the both ends.  After second round immunoprecipitated with cisplatin-specific anti-body, the Pt-DNA adducts were reversed by incubating in NaCN (200 mM) over-night.  Then the damage free DNAs were amplified by PCR to get XR-seq libraries and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272774 GSM3272774 GEO Accession GSM3272774 SRX4394594 GSM3272775 SRP153920 SRS3549845 GSM3272775 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).  Four hours after injecting cisplatin or saline solution (control group), the mice were sacrificed by carbon dioxide exposure, the kidneys, liver, lung and spleen were removed and washed extensively with cold phosphate buffered saline (PBS), and then homogenized them. The chromatin fraction was then pelleted. The supernatants (containing low molecular DNA-protein fragments) were harvested and immunoprecipitated (IP) with anti-TFIIH (p89 antibody (G-10), and p62 antibody (H-10), Santa-Cruz Biotechnology). The eluted DNA were isolated using phenol-chloroform and ethanol precipitation. The low-molecular excision products were immunoprecipitated with anti-TFIIH (p89 antibody and p62 antibody), and ligated to adaptors on the both ends.  After second round immunoprecipitated with cisplatin-specific anti-body, the Pt-DNA adducts were reversed by incubating in NaCN (200 mM) over-night.  Then the damage free DNAs were amplified by PCR to get XR-seq libraries and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272775 GSM3272775 GEO Accession GSM3272775 SRX4394595 GSM3272776 SRP153920 SRS3549846 GSM3272776 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).  Four hours after injecting cisplatin or saline solution (control group), the mice were sacrificed by carbon dioxide exposure, the kidneys, liver, lung and spleen were removed and washed extensively with cold phosphate buffered saline (PBS), and then homogenized them. The chromatin fraction was then pelleted. The supernatants (containing low molecular DNA-protein fragments) were harvested and immunoprecipitated (IP) with anti-TFIIH (p89 antibody (G-10), and p62 antibody (H-10), Santa-Cruz Biotechnology). The eluted DNA were isolated using phenol-chloroform and ethanol precipitation. The low-molecular excision products were immunoprecipitated with anti-TFIIH (p89 antibody and p62 antibody), and ligated to adaptors on the both ends.  After second round immunoprecipitated with cisplatin-specific anti-body, the Pt-DNA adducts were reversed by incubating in NaCN (200 mM) over-night.  Then the damage free DNAs were amplified by PCR to get XR-seq libraries and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272776 GSM3272776 GEO Accession GSM3272776 SRX4394596 GSM3272777 SRP153920 SRS3549847 GSM3272777 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).  Four hours after injecting cisplatin or saline solution (control group), the mice were sacrificed by carbon dioxide exposure, the kidneys, liver, lung and spleen were removed and washed extensively with cold phosphate buffered saline (PBS), and then homogenized them. The chromatin fraction was then pelleted. The supernatants (containing low molecular DNA-protein fragments) were harvested and immunoprecipitated (IP) with anti-TFIIH (p89 antibody (G-10), and p62 antibody (H-10), Santa-Cruz Biotechnology). The eluted DNA were isolated using phenol-chloroform and ethanol precipitation. The low-molecular excision products were immunoprecipitated with anti-TFIIH (p89 antibody and p62 antibody), and ligated to adaptors on the both ends.  After second round immunoprecipitated with cisplatin-specific anti-body, the Pt-DNA adducts were reversed by incubating in NaCN (200 mM) over-night.  Then the damage free DNAs were amplified by PCR to get XR-seq libraries and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272777 GSM3272777 GEO Accession GSM3272777 SRX4394597 GSM3272778 SRP153920 SRS3549848 GSM3272778 OTHER GENOMIC other  Genomic DNA were extracted using PurLink Genomic DNA kit (Thermo).  Four hours after injecting cisplatin or saline solution (control group), the mice were sacrificed by carbon dioxide exposure, the kidneys, liver, lung and spleen were removed and washed extensively with cold phosphate buffered saline (PBS), and then homogenized them. The chromatin fraction was then pelleted. The supernatants (containing low molecular DNA-protein fragments) were harvested and immunoprecipitated (IP) with anti-TFIIH (p89 antibody (G-10), and p62 antibody (H-10), Santa-Cruz Biotechnology). The eluted DNA were isolated using phenol-chloroform and ethanol precipitation. The low-molecular excision products were immunoprecipitated with anti-TFIIH (p89 antibody and p62 antibody), and ligated to adaptors on the both ends.  After second round immunoprecipitated with cisplatin-specific anti-body, the Pt-DNA adducts were reversed by incubating in NaCN (200 mM) over-night.  Then the damage free DNAs were amplified by PCR to get XR-seq libraries and sequenced using an Illumina HiSeq 4000 with 50-bp single-end read. Illumina HiSeq 4000 gds 303272778 GSM3272778 GEO Accession GSM3272778 SRX4394598 GSM3272779 SRP153920 SRS3549849 GSM3272779 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272779 GSM3272779 GEO Accession GSM3272779 SRX4394599 GSM3272780 SRP153920 SRS3549850 GSM3272780 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272780 GSM3272780 GEO Accession GSM3272780 SRX4394600 GSM3272781 SRP153920 SRS3549851 GSM3272781 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272781 GSM3272781 GEO Accession GSM3272781 SRX4394601 GSM3272782 SRP153920 SRS3549852 GSM3272782 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272782 GSM3272782 GEO Accession GSM3272782 SRX4394602 GSM3272783 SRP153920 SRS3549853 GSM3272783 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272783 GSM3272783 GEO Accession GSM3272783 SRX4394603 GSM3272784 SRP153920 SRS3549854 GSM3272784 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272784 GSM3272784 GEO Accession GSM3272784 SRX4394604 GSM3272785 SRP153920 SRS3549855 GSM3272785 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272785 GSM3272785 GEO Accession GSM3272785 SRX4394605 GSM3272786 SRP153920 SRS3549856 GSM3272786 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272786 GSM3272786 GEO Accession GSM3272786 SRX4394606 GSM3272787 SRP153920 SRS3549857 GSM3272787 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272787 GSM3272787 GEO Accession GSM3272787 SRX4394607 GSM3272788 SRP153920 SRS3549858 GSM3272788 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272788 GSM3272788 GEO Accession GSM3272788 SRX4394608 GSM3272789 SRP153920 SRS3549859 GSM3272789 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272789 GSM3272789 GEO Accession GSM3272789 SRX4394609 GSM3272790 SRP153920 SRS3549860 GSM3272790 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272790 GSM3272790 GEO Accession GSM3272790 SRX4394610 GSM3272791 SRP153920 SRS3549861 GSM3272791 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272791 GSM3272791 GEO Accession GSM3272791 SRX4394611 GSM3272792 SRP153920 SRS3549862 GSM3272792 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272792 GSM3272792 GEO Accession GSM3272792 SRX4394612 GSM3272793 SRP153920 SRS3549863 GSM3272793 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272793 GSM3272793 GEO Accession GSM3272793 SRX4394613 GSM3272794 SRP153920 SRS3549864 GSM3272794 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was extracted from mouse kidney, liver, lung and spleen using TRIzol RNA extraction (Thermo Fisher Scientific).  After phase separation, RNA was purified using the PureLink RNA Mini Kit (Thermo Fisher Scientific).  Purified total RNA sample was treated with DNase I (TURBO DNA-freeTM kit, Ambion Inc.) to remove traces of DNA.  RNA library was prepared using NEBNext Ultra RNA library prep kit (Illumina) according to manufacturer's instruction.  Total RNA starting with 1ug was poly-A selected, fragmented by random priming and then converted to cDNA using ProtoScript II reverse transcriptase.  The cDNA was then end-repaired, adenylated and ligated with Illumina sequencing adaptors.  Libraries from all samples were pooled and sequenced using an Illumina HiSeq 4000 with 50-bp pair-end read. Illumina HiSeq 4000 gds 303272794 GSM3272794 GEO Accession GSM3272794