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    <TITLE>GSM3293966: Sult2B1b knockdown, Batch1 (013876_A1); Homo sapiens; RNA-Seq</TITLE>
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    <TITLE>GSM3293967: Sult2B1b knockdown, Batch1 (013877_C1); Homo sapiens; RNA-Seq</TITLE>
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        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
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    <TITLE>GSM3293968: Sult2B1b knockdown, Batch1 (013878_E1); Homo sapiens; RNA-Seq</TITLE>
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        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
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    <TITLE>GSM3293969: Sult2B1b knockdown, Batch1 (013879_H1); Homo sapiens; RNA-Seq</TITLE>
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        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
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    <TITLE>GSM3293970: Sult2B1b knockdown, Batch1 (013880_A2); Homo sapiens; RNA-Seq</TITLE>
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        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
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      <PRIMARY_ID>SRX4409686</PRIMARY_ID>
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    <TITLE>GSM3293971: Sult2B1b knockdown, Batch1 (013881_B2); Homo sapiens; RNA-Seq</TITLE>
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          <PRIMARY_ID>SRS3563319</PRIMARY_ID>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
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    <TITLE>GSM3293973: Sult2B1b knockdown, Batch1 (013883_D2); Homo sapiens; RNA-Seq</TITLE>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
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        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
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    <TITLE>GSM3293974: Sult2B1b knockdown, Batch1 (013884_G2); Homo sapiens; RNA-Seq</TITLE>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
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        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
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    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409690</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293975</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293975: Sult2B1b knockdown, Batch1 (013885_H2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563323">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563323</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293975</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293975</ID>
          <LABEL>GSM3293975</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293975</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293976" accession="SRX4409691">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409691</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293976</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293976: Sult2B1b knockdown, Batch1 (013886_B3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563324">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563324</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293976</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293976</ID>
          <LABEL>GSM3293976</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293976</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293977" accession="SRX4409692">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409692</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293977</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293977: Sult2B1b knockdown, Batch1 (013887_C3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563325">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563325</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293977</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293977</ID>
          <LABEL>GSM3293977</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293977</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293978" accession="SRX4409693">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409693</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293978</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293978: Sult2B1b knockdown, Batch1 (013888_D3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563327">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563327</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293978</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293978</ID>
          <LABEL>GSM3293978</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293978</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293979" accession="SRX4409694">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409694</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293979</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293979: Sult2B1b knockdown, Batch1 (013889_F3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563328">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563328</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293979</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293979</ID>
          <LABEL>GSM3293979</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293979</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293980" accession="SRX4409695">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409695</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293980</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293980: Sult2B1b knockdown, Batch1 (013890_H3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563326">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563326</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293980</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293980</ID>
          <LABEL>GSM3293980</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293980</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293981" accession="SRX4409696">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409696</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293981</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293981: Sult2B1b knockdown, Batch1 (013891_B4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563329">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563329</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293981</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293981</ID>
          <LABEL>GSM3293981</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293981</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293982" accession="SRX4409697">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409697</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293982</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293982: Sult2B1b knockdown, Batch1 (013892_C4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563331">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563331</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293982</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293982</ID>
          <LABEL>GSM3293982</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293982</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293983" accession="SRX4409698">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409698</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293983</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293983: Sult2B1b knockdown, Batch1 (013893_D4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563330">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563330</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293983</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293983</ID>
          <LABEL>GSM3293983</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293983</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293984" accession="SRX4409699">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409699</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293984</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293984: Sult2B1b knockdown, Batch1 (013894_E4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563332">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563332</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293984</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293984</ID>
          <LABEL>GSM3293984</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293984</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293985" accession="SRX4409700">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409700</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293985</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293985: Sult2B1b knockdown, Batch1 (013895_F4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563334">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563334</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293985</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293985</ID>
          <LABEL>GSM3293985</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293985</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293986" accession="SRX4409701">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409701</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293986</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293986: Sult2B1b knockdown, Batch1 (013896_G4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563333">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563333</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293986</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293986</ID>
          <LABEL>GSM3293986</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293986</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293987" accession="SRX4409702">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409702</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293987</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293987: Sult2B1b knockdown, Batch1 (013897_A5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563335">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563335</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293987</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293987</ID>
          <LABEL>GSM3293987</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293987</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293988" accession="SRX4409703">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409703</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293988</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293988: Sult2B1b knockdown, Batch1 (013898_B5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563336">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563336</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293988</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293988</ID>
          <LABEL>GSM3293988</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293988</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293989" accession="SRX4409704">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409704</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293989</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293989: Sult2B1b knockdown, Batch1 (013899_C5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563337">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563337</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293989</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293989</ID>
          <LABEL>GSM3293989</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293989</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293990" accession="SRX4409705">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409705</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293990</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293990: Sult2B1b knockdown, Batch1 (013900_D5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563338">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563338</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293990</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293990</ID>
          <LABEL>GSM3293990</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293990</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293991" accession="SRX4409706">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409706</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293991</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293991: Sult2B1b knockdown, Batch1 (013901_E5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563339">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563339</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293991</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293991</ID>
          <LABEL>GSM3293991</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293991</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293992" accession="SRX4409707">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409707</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293992</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293992: Sult2B1b knockdown, Batch1 (013902_F5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563340">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563340</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293992</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293992</ID>
          <LABEL>GSM3293992</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293992</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293993" accession="SRX4409708">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409708</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293993</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293993: Sult2B1b knockdown, Batch1 (013903_G5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563341">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563341</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293993</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293993</ID>
          <LABEL>GSM3293993</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293993</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293994" accession="SRX4409709">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409709</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293994</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293994: Sult2B1b knockdown, Batch1 (013904_D6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563343">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563343</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293994</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293994</ID>
          <LABEL>GSM3293994</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293994</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293995" accession="SRX4409710">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409710</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293995</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293995: Sult2B1b knockdown, Batch1 (013905_E6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563342">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563342</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293995</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293995</ID>
          <LABEL>GSM3293995</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293995</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293996" accession="SRX4409711">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409711</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293996</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293996: Sult2B1b knockdown, Batch1 (013906_G6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563345">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563345</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293996</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293996</ID>
          <LABEL>GSM3293996</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293996</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293997" accession="SRX4409712">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409712</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293997</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293997: Sult2B1b knockdown, Batch1 (013907_A7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563344">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563344</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293997</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293997</ID>
          <LABEL>GSM3293997</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293997</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293998" accession="SRX4409713">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409713</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293998</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293998: Sult2B1b knockdown, Batch1 (013908_B7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563346">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563346</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293998</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293998</ID>
          <LABEL>GSM3293998</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293998</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3293999" accession="SRX4409714">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409714</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3293999</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3293999: Sult2B1b knockdown, Batch1 (013909_C7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563347">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563347</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3293999</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303293999</ID>
          <LABEL>GSM3293999</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3293999</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294000" accession="SRX4409715">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409715</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294000</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294000: Sult2B1b knockdown, Batch1 (013910_D7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563348">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563348</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294000</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294000</ID>
          <LABEL>GSM3294000</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294000</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294001" accession="SRX4409716">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409716</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294001</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294001: Sult2B1b knockdown, Batch1 (013911_E7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563349">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563349</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294001</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294001</ID>
          <LABEL>GSM3294001</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294001</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294002" accession="SRX4409717">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409717</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294002</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294002: Sult2B1b knockdown, Batch1 (013912_F7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563350">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563350</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294002</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294002</ID>
          <LABEL>GSM3294002</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294002</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294003" accession="SRX4409718">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409718</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294003</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294003: Sult2B1b knockdown, Batch1 (013913_G7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563351">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563351</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294003</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294003</ID>
          <LABEL>GSM3294003</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294003</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294004" accession="SRX4409719">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409719</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294004</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294004: Sult2B1b knockdown, Batch1 (013914_H7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563352">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563352</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294004</ID>
          <LABEL>GSM3294004</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294004</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294005" accession="SRX4409720">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409720</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294005</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294005: Sult2B1b knockdown, Batch1 (013915_C8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563353">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563353</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294005</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294005</ID>
          <LABEL>GSM3294005</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294005</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294006" accession="SRX4409721">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409721</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294006</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294006: Sult2B1b knockdown, Batch1 (013916_D8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563354">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563354</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294006</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294006</ID>
          <LABEL>GSM3294006</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294006</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294007" accession="SRX4409722">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409722</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294007</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294007: Sult2B1b knockdown, Batch1 (013917_E8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563355">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563355</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294007</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294007</ID>
          <LABEL>GSM3294007</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294007</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294008" accession="SRX4409723">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409723</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294008</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294008: Sult2B1b knockdown, Batch1 (013918_G8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563356">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563356</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294008</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294008</ID>
          <LABEL>GSM3294008</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294008</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294009" accession="SRX4409724">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409724</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294009</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294009: Sult2B1b knockdown, Batch1 (013919_H8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563357">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563357</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294009</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294009</ID>
          <LABEL>GSM3294009</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294009</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294010" accession="SRX4409725">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409725</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294010</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294010: Sult2B1b knockdown, Batch1 (013920_B9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563358">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563358</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294010</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294010</ID>
          <LABEL>GSM3294010</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294010</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294011" accession="SRX4409726">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409726</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294011</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294011: Sult2B1b knockdown, Batch1 (013921_C9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563359">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563359</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294011</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294011</ID>
          <LABEL>GSM3294011</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294011</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294012" accession="SRX4409727">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409727</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294012</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294012: Sult2B1b knockdown, Batch1 (013922_E9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563360">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563360</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294012</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294012</ID>
          <LABEL>GSM3294012</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294012</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294013" accession="SRX4409728">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409728</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294013</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294013: Sult2B1b knockdown, Batch1 (013923_B10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563361">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563361</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294013</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294013</ID>
          <LABEL>GSM3294013</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294013</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294014" accession="SRX4409729">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409729</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294014</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294014: Sult2B1b knockdown, Batch1 (013924_C10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563362">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563362</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294014</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294014</ID>
          <LABEL>GSM3294014</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294014</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294015" accession="SRX4409730">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409730</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294015</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294015: Sult2B1b knockdown, Batch1 (013925_E10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563363">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563363</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294015</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294015</ID>
          <LABEL>GSM3294015</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294015</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294016" accession="SRX4409731">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409731</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294016</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294016: Sult2B1b knockdown, Batch1 (013926_F10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563364">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563364</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294016</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294016</ID>
          <LABEL>GSM3294016</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294016</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294017" accession="SRX4409732">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409732</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294017</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294017: Sult2B1b knockdown, Batch1 (013927_G10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563365">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563365</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294017</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294017</ID>
          <LABEL>GSM3294017</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294017</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294018" accession="SRX4409733">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409733</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294018</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294018: Sult2B1b knockdown, Batch1 (013928_A11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563366">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563366</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294018</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294018</ID>
          <LABEL>GSM3294018</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294018</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294019" accession="SRX4409734">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409734</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294019</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294019: Sult2B1b knockdown, Batch1 (013929_B11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563367">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563367</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294019</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294019</ID>
          <LABEL>GSM3294019</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294019</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294020" accession="SRX4409735">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409735</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294020</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294020: Sult2B1b knockdown, Batch1 (013930_C11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563368">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563368</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294020</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294020</ID>
          <LABEL>GSM3294020</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294020</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294021" accession="SRX4409736">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409736</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294021</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294021: Sult2B1b knockdown, Batch1 (013931_E11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563369">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563369</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294021</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294021</ID>
          <LABEL>GSM3294021</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294021</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294022" accession="SRX4409737">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409737</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294022</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294022: Sult2B1b knockdown, Batch1 (013932_F11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563370">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563370</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294022</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294022</ID>
          <LABEL>GSM3294022</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294022</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294023" accession="SRX4409738">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409738</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294023</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294023: Sult2B1b knockdown, Batch1 (013933_G11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563372">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563372</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294023</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294023</ID>
          <LABEL>GSM3294023</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294023</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294024" accession="SRX4409739">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409739</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294024</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294024: Sult2B1b knockdown, Batch1 (013934_H11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563371">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563371</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294024</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294024</ID>
          <LABEL>GSM3294024</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294024</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294025" accession="SRX4409740">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409740</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294025</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294025: Sult2B1b knockdown, Batch1 (013935_A12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563373">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563373</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294025</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294025</ID>
          <LABEL>GSM3294025</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294025</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294026" accession="SRX4409741">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409741</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294026</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294026: Sult2B1b knockdown, Batch1 (013936_B12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563374">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563374</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294026</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294026</ID>
          <LABEL>GSM3294026</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294026</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294027" accession="SRX4409742">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409742</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294027</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294027: Sult2B1b knockdown, Batch1 (013937_C12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563375">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563375</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294027</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294027</ID>
          <LABEL>GSM3294027</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294027</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294028" accession="SRX4409743">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409743</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294028</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294028: Sult2B1b knockdown, Batch1 (013938_D12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563377">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563377</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294028</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294028</ID>
          <LABEL>GSM3294028</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294028</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294029" accession="SRX4409744">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409744</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294029</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294029: Sult2B1b knockdown, Batch1 (013939_E12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563376">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563376</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294029</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294029</ID>
          <LABEL>GSM3294029</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294029</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294030" accession="SRX4409745">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409745</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294030</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294030: Sult2B1b knockdown, Batch1 (013940_G12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563378">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563378</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294030</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294030</ID>
          <LABEL>GSM3294030</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294030</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294031" accession="SRX4409746">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409746</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294031</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294031: Sult2B1b knockdown, Batch1 (013941_H12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563379">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563379</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294031</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294031</ID>
          <LABEL>GSM3294031</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294031</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294032" accession="SRX4409747">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409747</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294032</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294032: Sult2B1b knockdown, Batch1 tube control with multiple cells (013942_ctrl-S); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563381">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563381</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294032</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294032</ID>
          <LABEL>GSM3294032</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294032</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294033" accession="SRX4409748">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409748</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294033</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294033: scrambled control, Batch1 (013943_B1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563382">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563382</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294033</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294033</ID>
          <LABEL>GSM3294033</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294033</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294034" accession="SRX4409749">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409749</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294034</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294034: scrambled control, Batch1 (013944_C1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563383">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563383</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294034</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294034</ID>
          <LABEL>GSM3294034</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294034</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294035" accession="SRX4409750">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409750</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294035</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294035: scrambled control, Batch1 (013945_E1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563384">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563384</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294035</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294035</ID>
          <LABEL>GSM3294035</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294035</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294036" accession="SRX4409751">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409751</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294036</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294036: scrambled control, Batch1 (013946_F1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563385">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563385</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294036</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294036</ID>
          <LABEL>GSM3294036</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294036</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294037" accession="SRX4409752">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409752</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294037</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294037: scrambled control, Batch1 (013947_G1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563386">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563386</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294037</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294037</ID>
          <LABEL>GSM3294037</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294037</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294038" accession="SRX4409753">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409753</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294038</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294038: scrambled control, Batch1 (013948_H1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563388">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563388</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294038</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294038</ID>
          <LABEL>GSM3294038</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294038</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294039" accession="SRX4409754">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409754</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294039</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294039: scrambled control, Batch1 (013949_C2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563389">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563389</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294039</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294039</ID>
          <LABEL>GSM3294039</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294039</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294040" accession="SRX4409755">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409755</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294040</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294040: scrambled control, Batch1 (013950_D2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563387">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563387</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294040</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294040</ID>
          <LABEL>GSM3294040</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294040</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294041" accession="SRX4409756">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409756</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294041</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294041: scrambled control, Batch1 (013951_F2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563390">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563390</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294041</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294041</ID>
          <LABEL>GSM3294041</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294041</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294042" accession="SRX4409757">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409757</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294042</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294042: scrambled control, Batch1 (013952_G2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563392">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563392</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294042</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294042</ID>
          <LABEL>GSM3294042</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294042</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294043" accession="SRX4409758">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409758</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294043</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294043: scrambled control, Batch1 (013953_H2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563391">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563391</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294043</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294043</ID>
          <LABEL>GSM3294043</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294043</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294044" accession="SRX4409759">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409759</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294044</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294044: scrambled control, Batch1 (013954_A3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563393">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563393</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294044</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294044</ID>
          <LABEL>GSM3294044</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294044</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294045" accession="SRX4409760">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409760</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294045</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294045: scrambled control, Batch1 (013955_C3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563394">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563394</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294045</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294045</ID>
          <LABEL>GSM3294045</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294045</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294046" accession="SRX4409761">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409761</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294046</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294046: scrambled control, Batch1 (013956_F3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563395">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563395</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294046</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294046</ID>
          <LABEL>GSM3294046</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294046</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294047" accession="SRX4409762">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409762</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294047</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294047: scrambled control, Batch1 (013957_A4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563396">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563396</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294047</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294047</ID>
          <LABEL>GSM3294047</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294047</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294048" accession="SRX4409763">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409763</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294048</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294048: scrambled control, Batch1 (013958_B4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563397">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563397</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294048</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294048</ID>
          <LABEL>GSM3294048</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294048</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294049" accession="SRX4409764">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409764</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294049</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294049: scrambled control, Batch1 (013959_C4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563398">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563398</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294049</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294049</ID>
          <LABEL>GSM3294049</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294049</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294050" accession="SRX4409765">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409765</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294050</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294050: scrambled control, Batch1 (013960_D4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563399">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563399</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294050</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294050</ID>
          <LABEL>GSM3294050</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294050</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294051" accession="SRX4409766">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409766</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294051</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294051: scrambled control, Batch1 (013961_E4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563400">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563400</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294051</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294051</ID>
          <LABEL>GSM3294051</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294051</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294052" accession="SRX4409767">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409767</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294052</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294052: scrambled control, Batch1 (013962_F4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563401">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563401</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294052</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294052</ID>
          <LABEL>GSM3294052</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294052</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294053" accession="SRX4409768">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409768</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294053</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294053: scrambled control, Batch1 (013963_G4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563402">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563402</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294053</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294053</ID>
          <LABEL>GSM3294053</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294053</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294054" accession="SRX4409769">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409769</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294054</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294054: scrambled control, Batch1 (013964_H4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563403">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563403</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294054</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294054</ID>
          <LABEL>GSM3294054</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294054</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294055" accession="SRX4409770">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409770</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294055</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294055: scrambled control, Batch1 (013965_A5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563404">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563404</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294055</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294055</ID>
          <LABEL>GSM3294055</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294055</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294056" accession="SRX4409771">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409771</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294056</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294056: scrambled control, Batch1 (013966_B5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563405">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563405</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294056</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294056</ID>
          <LABEL>GSM3294056</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294056</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294057" accession="SRX4409772">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409772</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294057</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294057: scrambled control, Batch1 (013967_C5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563407">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563407</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294057</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294057</ID>
          <LABEL>GSM3294057</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294057</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294058" accession="SRX4409773">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409773</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294058</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294058: scrambled control, Batch1 (013968_D5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563406">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563406</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294058</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294058</ID>
          <LABEL>GSM3294058</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294058</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294059" accession="SRX4409774">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409774</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294059</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294059: scrambled control, Batch1 (013969_E5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563408">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563408</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294059</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294059</ID>
          <LABEL>GSM3294059</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294059</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294060" accession="SRX4409775">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409775</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294060</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294060: scrambled control, Batch1 (013970_F5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563409">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563409</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294060</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294060</ID>
          <LABEL>GSM3294060</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294060</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294061" accession="SRX4409776">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409776</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294061</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294061: scrambled control, Batch1 (013971_G5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563410">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563410</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294061</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294061</ID>
          <LABEL>GSM3294061</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294061</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294062" accession="SRX4409777">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409777</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294062</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294062: scrambled control, Batch1 (013972_H5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563411">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563411</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294062</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294062</ID>
          <LABEL>GSM3294062</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294062</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294063" accession="SRX4409778">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409778</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294063</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294063: scrambled control, Batch1 (013973_A6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563412">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563412</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294063</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294063</ID>
          <LABEL>GSM3294063</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294063</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294064" accession="SRX4409779">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409779</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294064</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294064: scrambled control, Batch1 (013974_B6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563413">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563413</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294064</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294064</ID>
          <LABEL>GSM3294064</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294064</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294065" accession="SRX4409780">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409780</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294065</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294065: scrambled control, Batch1 (013975_C6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563414">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563414</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294065</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294065</ID>
          <LABEL>GSM3294065</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294065</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294066" accession="SRX4409781">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409781</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294066</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294066: scrambled control, Batch1 (013976_D6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563415">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563415</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294066</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294066</ID>
          <LABEL>GSM3294066</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294066</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294067" accession="SRX4409782">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409782</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294067</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294067: scrambled control, Batch1 (013977_E6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563416">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563416</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294067</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294067</ID>
          <LABEL>GSM3294067</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294067</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294068" accession="SRX4409783">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409783</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294068</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294068: scrambled control, Batch1 (013978_F6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563417">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563417</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294068</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294068</ID>
          <LABEL>GSM3294068</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294068</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294069" accession="SRX4409784">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409784</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294069</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294069: scrambled control, Batch1 (013979_G6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563418">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563418</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294069</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294069</ID>
          <LABEL>GSM3294069</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294069</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294070" accession="SRX4409785">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409785</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294070</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294070: scrambled control, Batch1 (013980_H6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563419">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563419</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294070</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294070</ID>
          <LABEL>GSM3294070</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294070</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294071" accession="SRX4409786">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409786</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294071</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294071: scrambled control, Batch1 (013981_B7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563420">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563420</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294071</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294071</ID>
          <LABEL>GSM3294071</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294071</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294072" accession="SRX4409787">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409787</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294072</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294072: scrambled control, Batch1 (013982_C7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563422">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563422</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294072</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294072</ID>
          <LABEL>GSM3294072</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294072</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294073" accession="SRX4409788">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409788</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294073</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294073: scrambled control, Batch1 (013983_F7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563423">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563423</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294073</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294073</ID>
          <LABEL>GSM3294073</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294073</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294074" accession="SRX4409789">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409789</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294074</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294074: scrambled control, Batch1 (013984_H7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563421">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563421</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294074</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294074</ID>
          <LABEL>GSM3294074</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294074</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294075" accession="SRX4409790">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409790</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294075</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294075: scrambled control, Batch1 (013985_A8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563424">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563424</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294075</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294075</ID>
          <LABEL>GSM3294075</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294075</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294076" accession="SRX4409791">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409791</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294076</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294076: scrambled control, Batch1 (013986_B8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563425">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563425</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294076</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294076</ID>
          <LABEL>GSM3294076</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294076</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294077" accession="SRX4409792">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409792</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294077</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294077: scrambled control, Batch1 (013987_C8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563427">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563427</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294077</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294077</ID>
          <LABEL>GSM3294077</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294077</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294078" accession="SRX4409793">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409793</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294078</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294078: scrambled control, Batch1 (013988_D8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563426">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563426</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294078</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294078</ID>
          <LABEL>GSM3294078</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294078</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294079" accession="SRX4409794">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409794</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294079</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294079: scrambled control, Batch1 (013989_E8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563428">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563428</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294079</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294079</ID>
          <LABEL>GSM3294079</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294079</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294080" accession="SRX4409795">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409795</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294080</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294080: scrambled control, Batch1 (013990_F8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563429">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563429</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294080</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294080</ID>
          <LABEL>GSM3294080</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294080</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294081" accession="SRX4409796">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409796</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294081</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294081: scrambled control, Batch1 (013991_G8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563430">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563430</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294081</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294081</ID>
          <LABEL>GSM3294081</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294081</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294082" accession="SRX4409797">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409797</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294082</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294082: scrambled control, Batch1 (013992_H8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563431">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563431</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294082</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294082</ID>
          <LABEL>GSM3294082</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294082</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294083" accession="SRX4409798">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409798</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294083</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294083: scrambled control, Batch1 (013993_A9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563432">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563432</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294083</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294083</ID>
          <LABEL>GSM3294083</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294083</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294084" accession="SRX4409799">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409799</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294084</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294084: scrambled control, Batch1 (013994_D9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563433">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563433</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294084</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294084</ID>
          <LABEL>GSM3294084</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294084</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294085" accession="SRX4409800">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409800</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294085</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294085: scrambled control, Batch1 (013995_E9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563434">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563434</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294085</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294085</ID>
          <LABEL>GSM3294085</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294085</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294086" accession="SRX4409801">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409801</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294086</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294086: scrambled control, Batch1 (013996_F9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563435">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563435</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294086</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294086</ID>
          <LABEL>GSM3294086</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294086</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294087" accession="SRX4409802">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409802</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294087</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294087: scrambled control, Batch1 (013997_G9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563436">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563436</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294087</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294087</ID>
          <LABEL>GSM3294087</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294087</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294088" accession="SRX4409803">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409803</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294088</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294088: scrambled control, Batch1 (013998_A10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563437">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563437</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294088</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294088</ID>
          <LABEL>GSM3294088</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294088</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294089" accession="SRX4409804">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409804</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294089</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294089: scrambled control, Batch1 (013999_B10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563438">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563438</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294089</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294089</ID>
          <LABEL>GSM3294089</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294089</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294090" accession="SRX4409805">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409805</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294090</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294090: scrambled control, Batch1 (014000_C10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563439">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563439</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294090</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294090</ID>
          <LABEL>GSM3294090</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294090</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294091" accession="SRX4409806">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409806</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294091</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294091: scrambled control, Batch1 (014001_D10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563440">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563440</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294091</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294091</ID>
          <LABEL>GSM3294091</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294091</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294092" accession="SRX4409807">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409807</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294092</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294092: scrambled control, Batch1 (014002_E10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563441">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563441</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294092</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294092</ID>
          <LABEL>GSM3294092</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294092</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294093" accession="SRX4409808">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409808</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294093</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294093: scrambled control, Batch1 (014003_F10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563442">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563442</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294093</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294093</ID>
          <LABEL>GSM3294093</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294093</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294094" accession="SRX4409809">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409809</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294094</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294094: scrambled control, Batch1 (014004_G10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563443">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563443</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294094</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294094</ID>
          <LABEL>GSM3294094</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294094</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294095" accession="SRX4409810">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409810</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294095</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294095: scrambled control, Batch1 (014005_A11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563444">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563444</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294095</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294095</ID>
          <LABEL>GSM3294095</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294095</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294096" accession="SRX4409811">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409811</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294096</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294096: scrambled control, Batch1 (014006_B11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563445">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563445</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294096</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294096</ID>
          <LABEL>GSM3294096</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294096</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294097" accession="SRX4409812">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409812</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294097</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294097: scrambled control, Batch1 (014007_C11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563446">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563446</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294097</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294097</ID>
          <LABEL>GSM3294097</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294097</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294098" accession="SRX4409813">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409813</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294098</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294098: scrambled control, Batch1 (014008_D11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563447">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563447</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294098</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294098</ID>
          <LABEL>GSM3294098</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294098</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294099" accession="SRX4409814">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409814</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294099</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294099: scrambled control, Batch1 (014009_E11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563449">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563449</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294099</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294099</ID>
          <LABEL>GSM3294099</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294099</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294100" accession="SRX4409815">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409815</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294100</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294100: scrambled control, Batch1 (014010_F11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563450">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563450</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294100</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294100</ID>
          <LABEL>GSM3294100</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294100</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294101" accession="SRX4409816">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409816</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294101</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294101: scrambled control, Batch1 (014011_G11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563448">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563448</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294101</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294101</ID>
          <LABEL>GSM3294101</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294101</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294102" accession="SRX4409817">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409817</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294102</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294102: scrambled control, Batch1 (014012_H11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563452">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563452</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294102</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294102</ID>
          <LABEL>GSM3294102</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294102</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294103" accession="SRX4409818">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409818</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294103</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294103: scrambled control, Batch1 (014013_B12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563451">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563451</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294103</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294103</ID>
          <LABEL>GSM3294103</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294103</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294104" accession="SRX4409819">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409819</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294104</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294104: scrambled control, Batch1 (014014_C12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563454">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563454</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294104</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294104</ID>
          <LABEL>GSM3294104</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294104</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294105" accession="SRX4409820">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409820</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294105</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294105: scrambled control, Batch1 (014015_E12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563453">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563453</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294105</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294105</ID>
          <LABEL>GSM3294105</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294105</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294106" accession="SRX4409821">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409821</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294106</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294106: scrambled control, Batch1 (014016_F12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563456">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563456</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294106</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294106</ID>
          <LABEL>GSM3294106</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294106</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294107" accession="SRX4409822">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409822</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294107</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294107: scrambled control, Batch1 (014017_G12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563455">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563455</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294107</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294107</ID>
          <LABEL>GSM3294107</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294107</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294108" accession="SRX4409823">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409823</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294108</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294108: scrambled control, Batch1 (014018_H12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563457">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563457</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294108</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294108</ID>
          <LABEL>GSM3294108</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294108</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294109" accession="SRX4409824">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409824</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294109</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294109: scrambled control, Batch1, multiple cells (014019_ctrl); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563458">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563458</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294109</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294109</ID>
          <LABEL>GSM3294109</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294109</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294110" accession="SRX4409825">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409825</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294110</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294110: scrambled control, Batch2 (014992_A1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563459">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563459</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294110</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294110</ID>
          <LABEL>GSM3294110</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294110</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294111" accession="SRX4409826">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409826</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294111</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294111: scrambled control, Batch2 (014993_B1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563460">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563460</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294111</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294111</ID>
          <LABEL>GSM3294111</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294111</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294112" accession="SRX4409827">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409827</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294112</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294112: scrambled control, Batch2 (014994_D1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563461">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563461</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294112</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294112</ID>
          <LABEL>GSM3294112</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294112</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294113" accession="SRX4409828">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409828</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294113</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294113: scrambled control, Batch2 (014995_E1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563462">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563462</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294113</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294113</ID>
          <LABEL>GSM3294113</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294113</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294114" accession="SRX4409829">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409829</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294114</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294114: scrambled control, Batch2 (014996_F1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563464">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563464</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294114</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294114</ID>
          <LABEL>GSM3294114</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294114</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294115" accession="SRX4409830">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409830</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294115</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294115: scrambled control, Batch2 (014997_G1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563463">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563463</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294115</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294115</ID>
          <LABEL>GSM3294115</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294115</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294116" accession="SRX4409831">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409831</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294116</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294116: scrambled control, Batch2 (014998_B2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563465">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563465</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294116</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294116</ID>
          <LABEL>GSM3294116</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294116</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294117" accession="SRX4409832">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409832</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294117</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294117: scrambled control, Batch2 (014999_D2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563466">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563466</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294117</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294117</ID>
          <LABEL>GSM3294117</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294117</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294118" accession="SRX4409833">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409833</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294118</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294118: scrambled control, Batch2 (015000_E2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563467">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563467</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294118</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294118</ID>
          <LABEL>GSM3294118</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294118</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294119" accession="SRX4409834">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409834</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294119</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294119: scrambled control, Batch2 (015001_A3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563468">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563468</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294119</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294119</ID>
          <LABEL>GSM3294119</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294119</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294120" accession="SRX4409835">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409835</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294120</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294120: scrambled control, Batch2 (015002_B3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563469">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563469</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294120</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294120</ID>
          <LABEL>GSM3294120</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294120</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294121" accession="SRX4409836">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409836</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294121</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294121: scrambled control, Batch2 (015003_E3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563470">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563470</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294121</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294121</ID>
          <LABEL>GSM3294121</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294121</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294122" accession="SRX4409837">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409837</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294122</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294122: scrambled control, Batch2 (015004_F3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563471">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563471</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294122</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294122</ID>
          <LABEL>GSM3294122</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294122</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294123" accession="SRX4409838">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409838</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294123</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294123: scrambled control, Batch2 (015005_A4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563472">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563472</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294123</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294123</ID>
          <LABEL>GSM3294123</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294123</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294124" accession="SRX4409839">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409839</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294124</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294124: scrambled control, Batch2 (015006_B4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563473">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563473</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294124</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294124</ID>
          <LABEL>GSM3294124</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294124</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294125" accession="SRX4409840">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409840</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294125</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294125: scrambled control, Batch2 (015007_C4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563477">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563477</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294125</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294125</ID>
          <LABEL>GSM3294125</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294125</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294126" accession="SRX4409841">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409841</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294126</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294126: scrambled control, Batch2 (015008_D4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563474">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563474</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294126</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294126</ID>
          <LABEL>GSM3294126</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294126</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294127" accession="SRX4409842">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409842</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294127</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294127: scrambled control, Batch2 (015009_E4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563476">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563476</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294127</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294127</ID>
          <LABEL>GSM3294127</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294127</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294128" accession="SRX4409843">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409843</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294128</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294128: scrambled control, Batch2 (015010_F4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563475">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563475</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294128</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294128</ID>
          <LABEL>GSM3294128</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294128</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294129" accession="SRX4409844">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409844</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294129</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294129: scrambled control, Batch2 (015011_G4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563479">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563479</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294129</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294129</ID>
          <LABEL>GSM3294129</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294129</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294130" accession="SRX4409845">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409845</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294130</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294130: scrambled control, Batch2 (015012_H4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563478">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563478</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294130</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294130</ID>
          <LABEL>GSM3294130</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294130</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294131" accession="SRX4409846">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409846</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294131</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294131: scrambled control, Batch2 (015013_A5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563480">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563480</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294131</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294131</ID>
          <LABEL>GSM3294131</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294131</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294132" accession="SRX4409847">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409847</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294132</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294132: scrambled control, Batch2 (015014_B5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563482">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563482</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294132</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294132</ID>
          <LABEL>GSM3294132</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294132</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294133" accession="SRX4409848">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409848</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294133</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294133: scrambled control, Batch2 (015015_C5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563481">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563481</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294133</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294133</ID>
          <LABEL>GSM3294133</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294133</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294134" accession="SRX4409849">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409849</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294134</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294134: scrambled control, Batch2 (015016_D5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563483">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563483</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294134</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294134</ID>
          <LABEL>GSM3294134</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294134</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294135" accession="SRX4409850">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409850</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294135</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294135: scrambled control, Batch2 (015017_E5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563484">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563484</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294135</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294135</ID>
          <LABEL>GSM3294135</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294135</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294136" accession="SRX4409851">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409851</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294136</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294136: scrambled control, Batch2 (015018_H5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563486">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563486</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294136</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294136</ID>
          <LABEL>GSM3294136</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294136</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294137" accession="SRX4409852">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409852</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294137</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294137: scrambled control, Batch2 (015019_A6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563485">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563485</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294137</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294137</ID>
          <LABEL>GSM3294137</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294137</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294138" accession="SRX4409853">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409853</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294138</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294138: scrambled control, Batch2 (015020_B6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563487">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563487</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294138</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294138</ID>
          <LABEL>GSM3294138</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294138</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294139" accession="SRX4409854">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409854</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294139</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294139: scrambled control, Batch2 (015021_C6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563489">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563489</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294139</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294139</ID>
          <LABEL>GSM3294139</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294139</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294140" accession="SRX4409855">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409855</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294140</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294140: scrambled control, Batch2 (015022_D6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563488">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563488</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294140</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294140</ID>
          <LABEL>GSM3294140</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294140</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294141" accession="SRX4409856">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409856</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294141</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294141: scrambled control, Batch2 (015023_E6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563490">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563490</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294141</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294141</ID>
          <LABEL>GSM3294141</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294141</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294142" accession="SRX4409857">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409857</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294142</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294142: scrambled control, Batch2 (015024_F6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563491">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563491</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294142</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294142</ID>
          <LABEL>GSM3294142</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294142</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294143" accession="SRX4409858">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409858</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294143</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294143: scrambled control, Batch2 (015025_G6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563492">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563492</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294143</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294143</ID>
          <LABEL>GSM3294143</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294143</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294144" accession="SRX4409859">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409859</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294144</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294144: scrambled control, Batch2 (015026_H6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563493">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563493</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294144</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294144</ID>
          <LABEL>GSM3294144</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294144</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294145" accession="SRX4409860">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409860</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294145</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294145: scrambled control, Batch2 (015027_A7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563631">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563631</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294145</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294145</ID>
          <LABEL>GSM3294145</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294145</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294146" accession="SRX4409861">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409861</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294146</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294146: scrambled control, Batch2 (015028_C7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563494">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563494</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294146</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294146</ID>
          <LABEL>GSM3294146</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294146</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294147" accession="SRX4409862">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409862</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294147</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294147: scrambled control, Batch2 (015029_D7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563495">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563495</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294147</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294147</ID>
          <LABEL>GSM3294147</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294147</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294148" accession="SRX4409863">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409863</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294148</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294148: scrambled control, Batch2 (015030_F7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563496">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563496</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294148</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294148</ID>
          <LABEL>GSM3294148</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294148</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294149" accession="SRX4409864">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409864</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294149</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294149: scrambled control, Batch2 (015031_H7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563497">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563497</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294149</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294149</ID>
          <LABEL>GSM3294149</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294149</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294150" accession="SRX4409865">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409865</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294150</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294150: scrambled control, Batch2 (015032_A8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563498">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563498</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294150</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294150</ID>
          <LABEL>GSM3294150</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294150</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294151" accession="SRX4409866">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409866</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294151</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294151: scrambled control, Batch2 (015033_C8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563499">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563499</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294151</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294151</ID>
          <LABEL>GSM3294151</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294151</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294152" accession="SRX4409867">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409867</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294152</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294152: scrambled control, Batch2 (015034_E8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563500">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563500</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294152</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294152</ID>
          <LABEL>GSM3294152</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294152</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294153" accession="SRX4409868">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409868</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294153</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294153: scrambled control, Batch2 (015035_B9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563502">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563502</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294153</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294153</ID>
          <LABEL>GSM3294153</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294153</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294154" accession="SRX4409869">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409869</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294154</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294154: scrambled control, Batch2 (015036_C9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563501">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563501</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294154</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294154</ID>
          <LABEL>GSM3294154</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294154</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294155" accession="SRX4409870">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409870</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294155</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294155: scrambled control, Batch2 (015037_E9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563503">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563503</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294155</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294155</ID>
          <LABEL>GSM3294155</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294155</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294156" accession="SRX4409871">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409871</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294156</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294156: scrambled control, Batch2 (015038_F9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563504">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563504</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294156</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294156</ID>
          <LABEL>GSM3294156</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294156</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294157" accession="SRX4409872">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409872</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294157</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294157: scrambled control, Batch2 (015039_A10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563505">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563505</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294157</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294157</ID>
          <LABEL>GSM3294157</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294157</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294158" accession="SRX4409873">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409873</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294158</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294158: scrambled control, Batch2 (015040_B10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563506">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563506</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294158</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294158</ID>
          <LABEL>GSM3294158</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294158</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294159" accession="SRX4409874">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409874</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294159</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294159: scrambled control, Batch2 (015041_C10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563507">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563507</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294159</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294159</ID>
          <LABEL>GSM3294159</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294159</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294160" accession="SRX4409875">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409875</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294160</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294160: scrambled control, Batch2 (015042_D10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563508">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563508</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294160</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294160</ID>
          <LABEL>GSM3294160</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294160</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294161" accession="SRX4409876">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409876</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294161</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294161: scrambled control, Batch2 (015043_E10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563509">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563509</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294161</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294161</ID>
          <LABEL>GSM3294161</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294161</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294162" accession="SRX4409877">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409877</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294162</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294162: scrambled control, Batch2 (015044_F10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563510">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563510</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294162</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294162</ID>
          <LABEL>GSM3294162</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294162</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294163" accession="SRX4409878">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409878</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294163</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294163: scrambled control, Batch2 (015045_G10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563511">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563511</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294163</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294163</ID>
          <LABEL>GSM3294163</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294163</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294164" accession="SRX4409879">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409879</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294164</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294164: scrambled control, Batch2 (015046_H10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563512">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563512</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294164</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294164</ID>
          <LABEL>GSM3294164</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294164</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294165" accession="SRX4409880">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409880</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294165</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294165: scrambled control, Batch2 (015047_A11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563513">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563513</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294165</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294165</ID>
          <LABEL>GSM3294165</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294165</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294166" accession="SRX4409881">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409881</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294166</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294166: scrambled control, Batch2 (015048_B11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563514">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563514</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294166</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294166</ID>
          <LABEL>GSM3294166</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294166</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294167" accession="SRX4409882">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409882</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294167</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294167: scrambled control, Batch2 (015049_F11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563515">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563515</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294167</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294167</ID>
          <LABEL>GSM3294167</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294167</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294168" accession="SRX4409883">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409883</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294168</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294168: scrambled control, Batch2 (015050_G11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563516">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563516</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294168</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294168</ID>
          <LABEL>GSM3294168</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294168</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294169" accession="SRX4409884">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409884</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294169</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294169: scrambled control, Batch2 (015051_H11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563517">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563517</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294169</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294169</ID>
          <LABEL>GSM3294169</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294169</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294170" accession="SRX4409885">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409885</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294170</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294170: scrambled control, Batch2 (015052_A12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563518">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563518</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294170</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294170</ID>
          <LABEL>GSM3294170</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294170</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294171" accession="SRX4409886">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409886</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294171</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294171: scrambled control, Batch2 (015053_B12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563519">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563519</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294171</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294171</ID>
          <LABEL>GSM3294171</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294171</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294172" accession="SRX4409887">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409887</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294172</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294172: scrambled control, Batch2 (015054_C12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563520">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563520</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294172</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294172</ID>
          <LABEL>GSM3294172</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294172</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294173" accession="SRX4409888">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409888</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294173</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294173: scrambled control, Batch2 (015055_D12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563521">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563521</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294173</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294173</ID>
          <LABEL>GSM3294173</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294173</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294174" accession="SRX4409889">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409889</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294174</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294174: scrambled control, Batch2 (015056_E12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563523">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563523</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294174</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294174</ID>
          <LABEL>GSM3294174</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294174</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294175" accession="SRX4409890">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409890</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294175</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294175: scrambled control, Batch2 (015057_F12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563522">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563522</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294175</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294175</ID>
          <LABEL>GSM3294175</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294175</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294176" accession="SRX4409891">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409891</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294176</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294176: scrambled control, Batch2 (015058_G12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563524">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563524</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294176</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294176</ID>
          <LABEL>GSM3294176</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294176</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294177" accession="SRX4409892">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409892</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294177</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294177: scrambled control, Batch2, multiple cells (015059_2a-tube-control); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563525">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563525</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294177</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294177</ID>
          <LABEL>GSM3294177</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294177</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294178" accession="SRX4409893">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409893</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294178</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294178: Sult2B1b knockdown, Batch2 (015060_A1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563526">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563526</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294178</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294178</ID>
          <LABEL>GSM3294178</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294178</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294179" accession="SRX4409894">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409894</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294179</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294179: Sult2B1b knockdown, Batch2 (015061_B1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563528">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563528</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294179</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294179</ID>
          <LABEL>GSM3294179</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294179</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294180" accession="SRX4409895">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409895</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294180</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294180: Sult2B1b knockdown, Batch2 (015062_C1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563530">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563530</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294180</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294180</ID>
          <LABEL>GSM3294180</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294180</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294181" accession="SRX4409896">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409896</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294181</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294181: Sult2B1b knockdown, Batch2 (015063_D1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563527">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563527</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294181</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294181</ID>
          <LABEL>GSM3294181</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294181</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294182" accession="SRX4409897">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409897</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294182</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294182: Sult2B1b knockdown, Batch2 (015064_E1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563532">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563532</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294182</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294182</ID>
          <LABEL>GSM3294182</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294182</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294183" accession="SRX4409898">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409898</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294183</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294183: Sult2B1b knockdown, Batch2 (015065_H1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563529">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563529</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294183</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294183</ID>
          <LABEL>GSM3294183</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294183</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294184" accession="SRX4409899">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409899</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294184</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294184: Sult2B1b knockdown, Batch2 (015066_C2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563531">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563531</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294184</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294184</ID>
          <LABEL>GSM3294184</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294184</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294185" accession="SRX4409900">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409900</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294185</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294185: Sult2B1b knockdown, Batch2 (015067_D2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563533">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563533</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294185</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294185</ID>
          <LABEL>GSM3294185</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294185</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294186" accession="SRX4409901">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409901</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294186</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294186: Sult2B1b knockdown, Batch2 (015068_E2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563536">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563536</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294186</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294186</ID>
          <LABEL>GSM3294186</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294186</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294187" accession="SRX4409902">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409902</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294187</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294187: Sult2B1b knockdown, Batch2 (015069_A3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563534">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563534</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294187</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294187</ID>
          <LABEL>GSM3294187</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294187</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294188" accession="SRX4409903">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409903</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294188</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294188: Sult2B1b knockdown, Batch2 (015070_B3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563535">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563535</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294188</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294188</ID>
          <LABEL>GSM3294188</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294188</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294189" accession="SRX4409904">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409904</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294189</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294189: Sult2B1b knockdown, Batch2 (015071_C3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563537">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563537</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294189</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294189</ID>
          <LABEL>GSM3294189</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294189</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294190" accession="SRX4409905">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409905</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294190</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294190: Sult2B1b knockdown, Batch2 (015072_E3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563538">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563538</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294190</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294190</ID>
          <LABEL>GSM3294190</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294190</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294191" accession="SRX4409906">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409906</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294191</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294191: Sult2B1b knockdown, Batch2 (015073_F3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563539">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563539</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294191</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294191</ID>
          <LABEL>GSM3294191</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294191</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294192" accession="SRX4409907">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409907</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294192</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294192: Sult2B1b knockdown, Batch2 (015074_A4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563540">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563540</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294192</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294192</ID>
          <LABEL>GSM3294192</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294192</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294193" accession="SRX4409908">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409908</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294193</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294193: Sult2B1b knockdown, Batch2 (015075_B4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563541">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563541</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294193</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294193</ID>
          <LABEL>GSM3294193</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294193</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294194" accession="SRX4409909">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409909</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294194</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294194: Sult2B1b knockdown, Batch2 (015076_C4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563542">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563542</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294194</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294194</ID>
          <LABEL>GSM3294194</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294194</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294195" accession="SRX4409910">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409910</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294195</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294195: Sult2B1b knockdown, Batch2 (015077_D4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563544">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563544</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294195</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294195</ID>
          <LABEL>GSM3294195</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294195</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294196" accession="SRX4409911">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409911</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294196</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294196: Sult2B1b knockdown, Batch2 (015078_E4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563545">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563545</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294196</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294196</ID>
          <LABEL>GSM3294196</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294196</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294197" accession="SRX4409912">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409912</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294197</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294197: Sult2B1b knockdown, Batch2 (015079_G4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563543">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563543</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294197</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294197</ID>
          <LABEL>GSM3294197</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294197</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294198" accession="SRX4409913">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409913</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294198</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294198: Sult2B1b knockdown, Batch2 (015080_H4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563546">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563546</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294198</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294198</ID>
          <LABEL>GSM3294198</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294198</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294199" accession="SRX4409914">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409914</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294199</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294199: Sult2B1b knockdown, Batch2 (015081_A5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563548">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563548</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294199</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294199</ID>
          <LABEL>GSM3294199</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294199</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294200" accession="SRX4409915">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409915</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294200</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294200: Sult2B1b knockdown, Batch2 (015082_B5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563547">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563547</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294200</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294200</ID>
          <LABEL>GSM3294200</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294200</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294201" accession="SRX4409916">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409916</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294201</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294201: Sult2B1b knockdown, Batch2 (015083_C5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563549">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563549</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294201</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294201</ID>
          <LABEL>GSM3294201</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294201</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294202" accession="SRX4409917">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409917</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294202</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294202: Sult2B1b knockdown, Batch2 (015084_D5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563550">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563550</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294202</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294202</ID>
          <LABEL>GSM3294202</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294202</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294203" accession="SRX4409918">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409918</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294203</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294203: Sult2B1b knockdown, Batch2 (015085_E5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563552">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563552</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294203</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294203</ID>
          <LABEL>GSM3294203</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294203</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294204" accession="SRX4409919">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409919</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294204</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294204: Sult2B1b knockdown, Batch2 (015086_F5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563551">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563551</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294204</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294204</ID>
          <LABEL>GSM3294204</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294204</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294205" accession="SRX4409920">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409920</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294205</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294205: Sult2B1b knockdown, Batch2 (015087_G5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563554">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563554</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294205</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294205</ID>
          <LABEL>GSM3294205</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294205</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294206" accession="SRX4409921">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409921</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294206</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294206: Sult2B1b knockdown, Batch2 (015088_A6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563553">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563553</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294206</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294206</ID>
          <LABEL>GSM3294206</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294206</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294207" accession="SRX4409922">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409922</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294207</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294207: Sult2B1b knockdown, Batch2 (015089_B6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563555">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563555</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294207</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294207</ID>
          <LABEL>GSM3294207</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294207</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294208" accession="SRX4409923">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409923</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294208</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294208: Sult2B1b knockdown, Batch2 (015090_D6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563556">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563556</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294208</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294208</ID>
          <LABEL>GSM3294208</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294208</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294209" accession="SRX4409924">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409924</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294209</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294209: Sult2B1b knockdown, Batch2 (015091_E6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563558">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563558</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294209</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294209</ID>
          <LABEL>GSM3294209</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294209</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294210" accession="SRX4409925">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409925</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294210</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294210: Sult2B1b knockdown, Batch2 (015092_F6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563557">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563557</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294210</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294210</ID>
          <LABEL>GSM3294210</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294210</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294211" accession="SRX4409926">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409926</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294211</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294211: Sult2B1b knockdown, Batch2 (015093_G6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563559">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563559</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294211</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294211</ID>
          <LABEL>GSM3294211</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294211</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294212" accession="SRX4409927">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409927</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294212</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294212: Sult2B1b knockdown, Batch2 (015094_H6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563560">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563560</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294212</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294212</ID>
          <LABEL>GSM3294212</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294212</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294213" accession="SRX4409928">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409928</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294213</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294213: Sult2B1b knockdown, Batch2 (015095_A7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563562">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563562</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294213</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294213</ID>
          <LABEL>GSM3294213</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294213</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294214" accession="SRX4409929">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409929</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294214</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294214: Sult2B1b knockdown, Batch2 (015096_B7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563561">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563561</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294214</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294214</ID>
          <LABEL>GSM3294214</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294214</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294215" accession="SRX4409930">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409930</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294215</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294215: Sult2B1b knockdown, Batch2 (015097_C7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563563">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563563</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294215</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294215</ID>
          <LABEL>GSM3294215</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294215</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294216" accession="SRX4409931">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409931</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294216</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294216: Sult2B1b knockdown, Batch2 (015098_D7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563565">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563565</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294216</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294216</ID>
          <LABEL>GSM3294216</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294216</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294217" accession="SRX4409932">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409932</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294217</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294217: Sult2B1b knockdown, Batch2 (015099_A8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563564">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563564</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294217</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294217</ID>
          <LABEL>GSM3294217</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294217</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294218" accession="SRX4409933">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409933</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294218</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294218: Sult2B1b knockdown, Batch2 (015100_B8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563566">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563566</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294218</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294218</ID>
          <LABEL>GSM3294218</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294218</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294219" accession="SRX4409934">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409934</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294219</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294219: Sult2B1b knockdown, Batch2 (015101_C8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563567">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563567</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294219</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294219</ID>
          <LABEL>GSM3294219</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294219</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294220" accession="SRX4409935">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409935</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294220</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294220: Sult2B1b knockdown, Batch2 (015102_D8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563568">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563568</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294220</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294220</ID>
          <LABEL>GSM3294220</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294220</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294221" accession="SRX4409936">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409936</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294221</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294221: Sult2B1b knockdown, Batch2 (015103_E8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563569">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563569</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294221</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294221</ID>
          <LABEL>GSM3294221</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294221</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294222" accession="SRX4409937">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409937</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294222</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294222: Sult2B1b knockdown, Batch2 (015104_F8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563570">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563570</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294222</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294222</ID>
          <LABEL>GSM3294222</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294222</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294223" accession="SRX4409938">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409938</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294223</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294223: Sult2B1b knockdown, Batch2 (015105_A9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563571">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563571</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294223</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294223</ID>
          <LABEL>GSM3294223</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294223</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294224" accession="SRX4409939">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409939</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294224</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294224: Sult2B1b knockdown, Batch2 (015106_B9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563573">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563573</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294224</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294224</ID>
          <LABEL>GSM3294224</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294224</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294225" accession="SRX4409940">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409940</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294225</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294225: Sult2B1b knockdown, Batch2 (015107_D9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563572">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563572</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294225</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294225</ID>
          <LABEL>GSM3294225</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294225</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294226" accession="SRX4409941">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409941</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294226</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294226: Sult2B1b knockdown, Batch2 (015108_A10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563577">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563577</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294226</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294226</ID>
          <LABEL>GSM3294226</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294226</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294227" accession="SRX4409942">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409942</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294227</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294227: Sult2B1b knockdown, Batch2 (015109_B10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563574">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563574</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294227</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294227</ID>
          <LABEL>GSM3294227</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294227</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294228" accession="SRX4409943">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409943</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294228</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294228: Sult2B1b knockdown, Batch2 (015110_C10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563575">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563575</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294228</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294228</ID>
          <LABEL>GSM3294228</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294228</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294229" accession="SRX4409944">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409944</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294229</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294229: Sult2B1b knockdown, Batch2 (015111_D10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563576">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563576</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294229</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294229</ID>
          <LABEL>GSM3294229</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294229</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294230" accession="SRX4409945">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409945</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294230</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294230: Sult2B1b knockdown, Batch2 (015112_E10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563578">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563578</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294230</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294230</ID>
          <LABEL>GSM3294230</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294230</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294231" accession="SRX4409946">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409946</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294231</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294231: Sult2B1b knockdown, Batch2 (015113_F10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563579">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563579</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294231</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294231</ID>
          <LABEL>GSM3294231</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294231</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294232" accession="SRX4409947">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409947</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294232</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294232: Sult2B1b knockdown, Batch2 (015114_G10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563581">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563581</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294232</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294232</ID>
          <LABEL>GSM3294232</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294232</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294233" accession="SRX4409948">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409948</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294233</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294233: Sult2B1b knockdown, Batch2 (015115_A11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563580">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563580</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294233</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294233</ID>
          <LABEL>GSM3294233</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294233</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294234" accession="SRX4409949">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409949</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294234</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294234: Sult2B1b knockdown, Batch2 (015116_B11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563582">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563582</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294234</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294234</ID>
          <LABEL>GSM3294234</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294234</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294235" accession="SRX4409950">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409950</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294235</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294235: Sult2B1b knockdown, Batch2 (015117_C11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563583">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563583</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294235</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294235</ID>
          <LABEL>GSM3294235</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294235</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294236" accession="SRX4409951">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409951</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294236</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294236: Sult2B1b knockdown, Batch2 (015118_D11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563585">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563585</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294236</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294236</ID>
          <LABEL>GSM3294236</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294236</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294237" accession="SRX4409952">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409952</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294237</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294237: Sult2B1b knockdown, Batch2 (015119_F11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563584">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563584</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294237</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294237</ID>
          <LABEL>GSM3294237</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294237</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294238" accession="SRX4409953">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409953</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294238</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294238: Sult2B1b knockdown, Batch2 (015120_G11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563588">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563588</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294238</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294238</ID>
          <LABEL>GSM3294238</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294238</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294239" accession="SRX4409954">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409954</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294239</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294239: Sult2B1b knockdown, Batch2 (015121_A12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563586">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563586</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294239</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294239</ID>
          <LABEL>GSM3294239</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294239</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294240" accession="SRX4409955">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409955</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294240</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294240: Sult2B1b knockdown, Batch2 (015122_C12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563587">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563587</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294240</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294240</ID>
          <LABEL>GSM3294240</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294240</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294241" accession="SRX4409956">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409956</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294241</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294241: Sult2B1b knockdown, Batch2 (015123_D12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563589">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563589</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294241</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294241</ID>
          <LABEL>GSM3294241</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294241</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294242" accession="SRX4409957">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409957</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294242</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294242: Sult2B1b knockdown, Batch2 (015124_E12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563590">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563590</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294242</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294242</ID>
          <LABEL>GSM3294242</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294242</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294243" accession="SRX4409958">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409958</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294243</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294243: Sult2B1b knockdown, Batch2 (015125_F12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563728">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563728</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294243</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294243</ID>
          <LABEL>GSM3294243</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294243</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294244" accession="SRX4409959">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409959</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294244</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294244: Sult2B1b knockdown, Batch2 (015126_G12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563592">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563592</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294244</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294244</ID>
          <LABEL>GSM3294244</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294244</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294245" accession="SRX4409960">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409960</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294245</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294245: Sult2B1b knockdown, Batch2 (015127_H12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563593">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563593</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294245</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294245</ID>
          <LABEL>GSM3294245</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294245</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294246" accession="SRX4409961">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409961</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294246</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294246: Sult2B1b knockdown, Batch2, multiple cells control (015128_2b-Tube-control); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563594">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563594</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294246</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294246</ID>
          <LABEL>GSM3294246</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294246</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294247" accession="SRX4409962">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409962</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294247</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294247: scrambled control, Batch3 (015129_A1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563591">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563591</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294247</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294247</ID>
          <LABEL>GSM3294247</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294247</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294248" accession="SRX4409963">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409963</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294248</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294248: scrambled control, Batch3 (015130_D1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563595">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563595</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294248</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294248</ID>
          <LABEL>GSM3294248</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294248</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294249" accession="SRX4409964">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409964</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294249</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294249: scrambled control, Batch3 (015131_F1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563596">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563596</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294249</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294249</ID>
          <LABEL>GSM3294249</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294249</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294250" accession="SRX4409965">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409965</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294250</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294250: scrambled control, Batch3 (015132_G1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563597">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563597</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294250</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294250</ID>
          <LABEL>GSM3294250</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294250</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294251" accession="SRX4409966">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409966</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294251</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294251: scrambled control, Batch3 (015133_A2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563598">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563598</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294251</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294251</ID>
          <LABEL>GSM3294251</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294251</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294252" accession="SRX4409967">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409967</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294252</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294252: scrambled control, Batch3 (015134_B2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563599">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563599</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294252</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294252</ID>
          <LABEL>GSM3294252</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294252</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294253" accession="SRX4409968">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409968</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294253</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294253: scrambled control, Batch3 (015135_C2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563600">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563600</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294253</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294253</ID>
          <LABEL>GSM3294253</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294253</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294254" accession="SRX4409969">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409969</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294254</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294254: scrambled control, Batch3 (015136_D2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563602">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563602</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294254</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294254</ID>
          <LABEL>GSM3294254</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294254</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294255" accession="SRX4409970">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409970</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294255</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294255: scrambled control, Batch3 (015137_E2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563601">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563601</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294255</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294255</ID>
          <LABEL>GSM3294255</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294255</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294256" accession="SRX4409971">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409971</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294256</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294256: scrambled control, Batch3 (015138_H2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563605">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563605</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294256</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294256</ID>
          <LABEL>GSM3294256</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294256</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294257" accession="SRX4409972">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409972</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294257</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294257: scrambled control, Batch3 (015139_A3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563603">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563603</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294257</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294257</ID>
          <LABEL>GSM3294257</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294257</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294258" accession="SRX4409973">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409973</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294258</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294258: scrambled control, Batch3 (015140_B3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563604">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563604</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294258</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294258</ID>
          <LABEL>GSM3294258</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294258</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294259" accession="SRX4409974">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409974</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294259</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294259: scrambled control, Batch3 (015141_C3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563606">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563606</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294259</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294259</ID>
          <LABEL>GSM3294259</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294259</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294260" accession="SRX4409975">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409975</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294260</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294260: scrambled control, Batch3 (015142_D3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563607">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563607</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294260</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294260</ID>
          <LABEL>GSM3294260</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294260</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294261" accession="SRX4409976">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409976</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294261</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294261: scrambled control, Batch3 (015143_E3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563608">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563608</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294261</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294261</ID>
          <LABEL>GSM3294261</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294261</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294262" accession="SRX4409977">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409977</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294262</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294262: scrambled control, Batch3 (015144_F3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563610">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563610</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294262</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294262</ID>
          <LABEL>GSM3294262</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294262</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294263" accession="SRX4409978">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409978</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294263</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294263: scrambled control, Batch3 (015145_G3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563612">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563612</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294263</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294263</ID>
          <LABEL>GSM3294263</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294263</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294264" accession="SRX4409979">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409979</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294264</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294264: scrambled control, Batch3 (015146_H3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563613">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563613</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294264</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294264</ID>
          <LABEL>GSM3294264</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294264</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294265" accession="SRX4409980">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409980</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294265</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294265: scrambled control, Batch3 (015147_C4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563609">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563609</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294265</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294265</ID>
          <LABEL>GSM3294265</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294265</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294266" accession="SRX4409981">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409981</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294266</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294266: scrambled control, Batch3 (015148_D4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563611">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563611</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294266</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294266</ID>
          <LABEL>GSM3294266</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294266</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294267" accession="SRX4409982">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409982</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294267</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294267: scrambled control, Batch3 (015149_E4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563614">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563614</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294267</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294267</ID>
          <LABEL>GSM3294267</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294267</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294268" accession="SRX4409983">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409983</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294268</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294268: scrambled control, Batch3 (015150_F4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563615">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563615</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294268</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294268</ID>
          <LABEL>GSM3294268</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294268</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294269" accession="SRX4409984">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409984</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294269</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294269: scrambled control, Batch3 (015151_G4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563616">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563616</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294269</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294269</ID>
          <LABEL>GSM3294269</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294269</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294270" accession="SRX4409985">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409985</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294270</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294270: scrambled control, Batch3 (015152_H4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563618">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563618</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294270</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294270</ID>
          <LABEL>GSM3294270</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294270</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294271" accession="SRX4409986">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409986</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294271</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294271: scrambled control, Batch3 (015153_A5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563617">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563617</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294271</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294271</ID>
          <LABEL>GSM3294271</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294271</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294272" accession="SRX4409987">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409987</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294272</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294272: scrambled control, Batch3 (015154_B5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563619">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563619</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294272</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294272</ID>
          <LABEL>GSM3294272</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294272</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294273" accession="SRX4409988">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409988</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294273</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294273: scrambled control, Batch3 (015155_C5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563620">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563620</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294273</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294273</ID>
          <LABEL>GSM3294273</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294273</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294274" accession="SRX4409989">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409989</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294274</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294274: scrambled control, Batch3 (015156_D5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563621">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563621</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294274</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294274</ID>
          <LABEL>GSM3294274</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294274</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294275" accession="SRX4409990">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409990</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294275</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294275: scrambled control, Batch3 (015157_F5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563622">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563622</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294275</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294275</ID>
          <LABEL>GSM3294275</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294275</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294276" accession="SRX4409991">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409991</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294276</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294276: scrambled control, Batch3 (015158_G5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563623">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563623</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294276</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294276</ID>
          <LABEL>GSM3294276</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294276</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294277" accession="SRX4409992">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409992</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294277</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294277: scrambled control, Batch3 (015159_H5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563624">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563624</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294277</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294277</ID>
          <LABEL>GSM3294277</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294277</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294278" accession="SRX4409993">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409993</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294278</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294278: scrambled control, Batch3 (015160_A6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563626">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563626</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294278</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294278</ID>
          <LABEL>GSM3294278</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294278</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294279" accession="SRX4409994">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409994</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294279</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294279: scrambled control, Batch3 (015161_C6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563627">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563627</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294279</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294279</ID>
          <LABEL>GSM3294279</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294279</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294280" accession="SRX4409995">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409995</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294280</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294280: scrambled control, Batch3 (015162_D6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563625">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563625</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294280</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294280</ID>
          <LABEL>GSM3294280</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294280</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294281" accession="SRX4409996">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409996</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294281</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294281: scrambled control, Batch3 (015163_E6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563628">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563628</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294281</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294281</ID>
          <LABEL>GSM3294281</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294281</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294282" accession="SRX4409997">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409997</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294282</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294282: scrambled control, Batch3 (015164_F6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563629">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563629</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294282</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294282</ID>
          <LABEL>GSM3294282</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294282</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294283" accession="SRX4409998">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409998</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294283</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294283: scrambled control, Batch3 (015165_G6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563630">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563630</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294283</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294283</ID>
          <LABEL>GSM3294283</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294283</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294284" accession="SRX4409999">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4409999</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294284</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294284: scrambled control, Batch3 (015166_H6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563633">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563633</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294284</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294284</ID>
          <LABEL>GSM3294284</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294284</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294285" accession="SRX4410000">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410000</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294285</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294285: scrambled control, Batch3 (015167_A7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563632">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563632</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294285</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294285</ID>
          <LABEL>GSM3294285</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294285</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294286" accession="SRX4410001">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410001</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294286</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294286: scrambled control, Batch3 (015168_C7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563634">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563634</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294286</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294286</ID>
          <LABEL>GSM3294286</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294286</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294287" accession="SRX4410002">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410002</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294287</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294287: scrambled control, Batch3 (015169_D7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563635">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563635</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294287</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294287</ID>
          <LABEL>GSM3294287</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294287</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294288" accession="SRX4410003">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410003</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294288</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294288: scrambled control, Batch3 (015170_G7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563636">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563636</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294288</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294288</ID>
          <LABEL>GSM3294288</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294288</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294289" accession="SRX4410004">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410004</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294289</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294289: scrambled control, Batch3 (015171_H7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563640">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563640</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294289</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294289</ID>
          <LABEL>GSM3294289</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294289</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294290" accession="SRX4410005">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410005</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294290</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294290: scrambled control, Batch3 (015172_A8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563637">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563637</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294290</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294290</ID>
          <LABEL>GSM3294290</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294290</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294291" accession="SRX4410006">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410006</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294291</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294291: scrambled control, Batch3 (015173_D8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563638">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563638</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294291</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294291</ID>
          <LABEL>GSM3294291</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294291</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294292" accession="SRX4410007">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410007</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294292</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294292: scrambled control, Batch3 (015174_F8); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563639">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563639</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294292</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294292</ID>
          <LABEL>GSM3294292</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294292</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294293" accession="SRX4410008">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410008</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294293</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294293: scrambled control, Batch3 (015175_A9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563641">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563641</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294293</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294293</ID>
          <LABEL>GSM3294293</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294293</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294294" accession="SRX4410009">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410009</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294294</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294294: scrambled control, Batch3 (015176_B9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563642">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563642</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294294</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294294</ID>
          <LABEL>GSM3294294</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294294</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294295" accession="SRX4410010">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410010</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294295</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294295: scrambled control, Batch3 (015177_D9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563644">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563644</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294295</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294295</ID>
          <LABEL>GSM3294295</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294295</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294296" accession="SRX4410011">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410011</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294296</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294296: scrambled control, Batch3 (015178_G9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563643">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563643</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294296</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294296</ID>
          <LABEL>GSM3294296</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294296</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294297" accession="SRX4410012">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410012</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294297</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294297: scrambled control, Batch3 (015179_A10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563645">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563645</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294297</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294297</ID>
          <LABEL>GSM3294297</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294297</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294298" accession="SRX4410013">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410013</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294298</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294298: scrambled control, Batch3 (015180_C10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563646">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563646</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294298</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294298</ID>
          <LABEL>GSM3294298</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294298</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294299" accession="SRX4410014">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410014</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294299</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294299: scrambled control, Batch3 (015181_F10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563647">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563647</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294299</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294299</ID>
          <LABEL>GSM3294299</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294299</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294300" accession="SRX4410015">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410015</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294300</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294300: scrambled control, Batch3 (015182_G10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563648">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563648</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294300</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294300</ID>
          <LABEL>GSM3294300</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294300</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294301" accession="SRX4410016">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410016</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294301</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294301: scrambled control, Batch3 (015183_H10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563649">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563649</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294301</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294301</ID>
          <LABEL>GSM3294301</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294301</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294302" accession="SRX4410017">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410017</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294302</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294302: scrambled control, Batch3 (015184_A11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563650">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563650</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294302</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294302</ID>
          <LABEL>GSM3294302</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294302</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294303" accession="SRX4410018">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410018</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294303</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294303: scrambled control, Batch3 (015185_B11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563652">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563652</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294303</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294303</ID>
          <LABEL>GSM3294303</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294303</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294304" accession="SRX4410019">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410019</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294304</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294304: scrambled control, Batch3 (015186_C11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563651">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563651</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294304</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294304</ID>
          <LABEL>GSM3294304</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294304</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294305" accession="SRX4410020">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410020</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294305</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294305: scrambled control, Batch3 (015187_D11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563653">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563653</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294305</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294305</ID>
          <LABEL>GSM3294305</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294305</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294306" accession="SRX4410021">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410021</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294306</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294306: scrambled control, Batch3 (015188_E11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563654">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563654</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294306</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294306</ID>
          <LABEL>GSM3294306</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294306</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294307" accession="SRX4410022">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410022</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294307</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294307: scrambled control, Batch3 (015189_G11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563655">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563655</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294307</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294307</ID>
          <LABEL>GSM3294307</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294307</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294308" accession="SRX4410023">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410023</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294308</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294308: scrambled control, Batch3 (015190_A12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563656">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563656</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294308</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294308</ID>
          <LABEL>GSM3294308</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294308</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294309" accession="SRX4410024">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410024</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294309</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294309: scrambled control, Batch3 (015191_B12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563657">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563657</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294309</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294309</ID>
          <LABEL>GSM3294309</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294309</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294310" accession="SRX4410025">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410025</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294310</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294310: scrambled control, Batch3 (015192_C12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563658">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563658</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294310</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294310</ID>
          <LABEL>GSM3294310</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294310</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294311" accession="SRX4410026">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410026</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294311</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294311: scrambled control, Batch3 (015193_D12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563659">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563659</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294311</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294311</ID>
          <LABEL>GSM3294311</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294311</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294312" accession="SRX4410027">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410027</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294312</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294312: scrambled control, Batch3 (015194_E12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563660">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563660</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294312</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294312</ID>
          <LABEL>GSM3294312</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294312</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294313" accession="SRX4410028">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410028</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294313</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294313: scrambled control, Batch3 (015195_F12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563661">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563661</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294313</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294313</ID>
          <LABEL>GSM3294313</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294313</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294314" accession="SRX4410029">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410029</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294314</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294314: scrambled control, Batch3, multiple cell control (015196_3A-tube-control); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563662">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563662</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294314</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294314</ID>
          <LABEL>GSM3294314</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294314</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294315" accession="SRX4410030">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410030</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294315</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294315: Sult2B1b knock-down, Batch3 (015197_B1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563663">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563663</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294315</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294315</ID>
          <LABEL>GSM3294315</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294315</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294316" accession="SRX4410031">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410031</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294316</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294316: Sult2B1b knock-down, Batch3 (015198_C1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563666">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563666</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294316</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294316</ID>
          <LABEL>GSM3294316</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294316</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294317" accession="SRX4410032">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410032</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294317</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294317: Sult2B1b knock-down, Batch3 (015199_D1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563664">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563664</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294317</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294317</ID>
          <LABEL>GSM3294317</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294317</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294318" accession="SRX4410033">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410033</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294318</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294318: Sult2B1b knock-down, Batch3 (015200_E1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563668">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563668</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294318</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294318</ID>
          <LABEL>GSM3294318</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294318</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294319" accession="SRX4410034">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410034</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294319</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294319: Sult2B1b knock-down, Batch3 (015201_F1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563665">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563665</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294319</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294319</ID>
          <LABEL>GSM3294319</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294319</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294320" accession="SRX4410035">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410035</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294320</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294320: Sult2B1b knock-down, Batch3 (015202_H1); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563667">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563667</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294320</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294320</ID>
          <LABEL>GSM3294320</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294320</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294321" accession="SRX4410036">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410036</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294321</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294321: Sult2B1b knock-down, Batch3 (015203_B2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563669">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563669</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294321</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294321</ID>
          <LABEL>GSM3294321</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294321</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294322" accession="SRX4410037">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410037</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294322</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294322: Sult2B1b knock-down, Batch3 (015204_C2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563670">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563670</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294322</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294322</ID>
          <LABEL>GSM3294322</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294322</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294323" accession="SRX4410038">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410038</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294323</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294323: Sult2B1b knock-down, Batch3 (015205_D2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563672">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563672</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294323</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294323</ID>
          <LABEL>GSM3294323</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294323</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294324" accession="SRX4410039">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410039</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294324</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294324: Sult2B1b knock-down, Batch3 (015206_F2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563673">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563673</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294324</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294324</ID>
          <LABEL>GSM3294324</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294324</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294325" accession="SRX4410040">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410040</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294325</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294325: Sult2B1b knock-down, Batch3 (015207_H2); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563674">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563674</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294325</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294325</ID>
          <LABEL>GSM3294325</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294325</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294326" accession="SRX4410041">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410041</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294326</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294326: Sult2B1b knock-down, Batch3 (015208_A3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563671">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563671</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294326</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294326</ID>
          <LABEL>GSM3294326</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294326</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294327" accession="SRX4410042">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410042</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294327</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294327: Sult2B1b knock-down, Batch3 (015209_B3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563675">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563675</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294327</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294327</ID>
          <LABEL>GSM3294327</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294327</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294328" accession="SRX4410043">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410043</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294328</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294328: Sult2B1b knock-down, Batch3 (015210_C3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563677">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563677</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294328</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294328</ID>
          <LABEL>GSM3294328</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294328</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294329" accession="SRX4410044">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410044</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294329</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294329: Sult2B1b knock-down, Batch3 (015211_D3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563676">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563676</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294329</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294329</ID>
          <LABEL>GSM3294329</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294329</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294330" accession="SRX4410045">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410045</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294330</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294330: Sult2B1b knock-down, Batch3 (015212_G3); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563680">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563680</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294330</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294330</ID>
          <LABEL>GSM3294330</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294330</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294331" accession="SRX4410046">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410046</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294331</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294331: Sult2B1b knock-down, Batch3 (015213_A4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563678">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563678</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294331</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294331</ID>
          <LABEL>GSM3294331</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294331</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294332" accession="SRX4410047">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410047</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294332</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294332: Sult2B1b knock-down, Batch3 (015214_B4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563679">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563679</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294332</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294332</ID>
          <LABEL>GSM3294332</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294332</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294333" accession="SRX4410048">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410048</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294333</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294333: Sult2B1b knock-down, Batch3 (015215_C4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563681">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563681</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294333</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294333</ID>
          <LABEL>GSM3294333</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294333</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294334" accession="SRX4410049">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410049</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294334</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294334: Sult2B1b knock-down, Batch3 (015216_D4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563683">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563683</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294334</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294334</ID>
          <LABEL>GSM3294334</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294334</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294335" accession="SRX4410050">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410050</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294335</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294335: Sult2B1b knock-down, Batch3 (015217_E4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563682">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563682</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294335</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294335</ID>
          <LABEL>GSM3294335</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294335</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294336" accession="SRX4410051">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410051</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294336</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294336: Sult2B1b knock-down, Batch3 (015218_F4); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563685">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563685</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294336</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294336</ID>
          <LABEL>GSM3294336</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294336</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294337" accession="SRX4410052">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410052</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294337</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294337: Sult2B1b knock-down, Batch3 (015219_A5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563684">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563684</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294337</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294337</ID>
          <LABEL>GSM3294337</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294337</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294338" accession="SRX4410053">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410053</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294338</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294338: Sult2B1b knock-down, Batch3 (015220_B5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563686">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563686</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294338</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294338</ID>
          <LABEL>GSM3294338</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294338</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294339" accession="SRX4410054">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410054</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294339</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294339: Sult2B1b knock-down, Batch3 (015221_C5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563687">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563687</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294339</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294339</ID>
          <LABEL>GSM3294339</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294339</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294340" accession="SRX4410055">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410055</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294340</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294340: Sult2B1b knock-down, Batch3 (015222_D5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563688">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563688</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294340</ID>
          <LABEL>GSM3294340</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294340</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294341" accession="SRX4410056">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410056</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294341</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294341: Sult2B1b knock-down, Batch3 (015223_E5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563691">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563691</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294341</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294341</ID>
          <LABEL>GSM3294341</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294341</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294342" accession="SRX4410057">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410057</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294342</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294342: Sult2B1b knock-down, Batch3 (015224_G5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563692">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563692</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294342</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294342</ID>
          <LABEL>GSM3294342</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294342</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294343" accession="SRX4410058">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410058</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294343</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294343: Sult2B1b knock-down, Batch3 (015225_H5); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563690">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563690</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294343</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294343</ID>
          <LABEL>GSM3294343</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294343</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294344" accession="SRX4410059">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410059</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294344</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294344: Sult2B1b knock-down, Batch3 (015226_A6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563689">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563689</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294344</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294344</ID>
          <LABEL>GSM3294344</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294344</VALUE>
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    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294345" accession="SRX4410060">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410060</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294345</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294345: Sult2B1b knock-down, Batch3 (015227_G6); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563693">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563693</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294345</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294345</ID>
          <LABEL>GSM3294345</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294345</VALUE>
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  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294346" accession="SRX4410061">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410061</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294346</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294346: Sult2B1b knock-down, Batch3 (015228_A7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563694">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563694</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294346</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
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    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294346</ID>
          <LABEL>GSM3294346</LABEL>
        </XREF_LINK>
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    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294346</VALUE>
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    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294347" accession="SRX4410062">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410062</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294347</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294347: Sult2B1b knock-down, Batch3 (015229_C7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563695">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563695</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294347</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294347</ID>
          <LABEL>GSM3294347</LABEL>
        </XREF_LINK>
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    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294347</VALUE>
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    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294348" accession="SRX4410063">
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      <PRIMARY_ID>SRX4410063</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294348</SUBMITTER_ID>
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    <TITLE>GSM3294348: Sult2B1b knock-down, Batch3 (015230_E7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
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    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563696">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563696</PRIMARY_ID>
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        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
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    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294348</ID>
          <LABEL>GSM3294348</LABEL>
        </XREF_LINK>
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    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
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    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294349" accession="SRX4410064">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410064</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294349</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294349: Sult2B1b knock-down, Batch3 (015231_F7); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563697">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563697</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294349</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
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    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294349</ID>
          <LABEL>GSM3294349</LABEL>
        </XREF_LINK>
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    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
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    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294350" accession="SRX4410065">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410065</PRIMARY_ID>
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    <TITLE>GSM3294350: Sult2B1b knock-down, Batch3 (015232_B8); Homo sapiens; RNA-Seq</TITLE>
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      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563698">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563698</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294350</EXTERNAL_ID>
        </IDENTIFIERS>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
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    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
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    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294350</ID>
          <LABEL>GSM3294350</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294350</VALUE>
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    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294351" accession="SRX4410066">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410066</PRIMARY_ID>
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    <TITLE>GSM3294351: Sult2B1b knock-down, Batch3 (015233_D8); Homo sapiens; RNA-Seq</TITLE>
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      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563699">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563699</PRIMARY_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
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    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
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    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294351</ID>
          <LABEL>GSM3294351</LABEL>
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    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
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  <EXPERIMENT alias="GSM3294352" accession="SRX4410067">
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      <PRIMARY_ID>SRX4410067</PRIMARY_ID>
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    <TITLE>GSM3294352: Sult2B1b knock-down, Batch3 (015234_G8); Homo sapiens; RNA-Seq</TITLE>
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      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563701">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563701</PRIMARY_ID>
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      <LIBRARY_DESCRIPTOR>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
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    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294352</ID>
          <LABEL>GSM3294352</LABEL>
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    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294352</VALUE>
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    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294353" accession="SRX4410068">
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      <PRIMARY_ID>SRX4410068</PRIMARY_ID>
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    <TITLE>GSM3294353: Sult2B1b knock-down, Batch3 (015235_A9); Homo sapiens; RNA-Seq</TITLE>
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      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563700">
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          <PRIMARY_ID>SRS3563700</PRIMARY_ID>
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      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
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          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294353</ID>
          <LABEL>GSM3294353</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294353</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294354" accession="SRX4410069">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410069</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294354</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294354: Sult2B1b knock-down, Batch3 (015236_B9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563702">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563702</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294354</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294354</ID>
          <LABEL>GSM3294354</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294354</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294355" accession="SRX4410070">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410070</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294355</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294355: Sult2B1b knock-down, Batch3 (015237_C9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563704">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563704</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294355</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294355</ID>
          <LABEL>GSM3294355</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294355</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294356" accession="SRX4410071">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410071</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294356</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294356: Sult2B1b knock-down, Batch3 (015238_G9); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563703">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563703</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294356</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294356</ID>
          <LABEL>GSM3294356</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294356</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294357" accession="SRX4410072">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410072</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294357</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294357: Sult2B1b knock-down, Batch3 (015239_B10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563706">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563706</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294357</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294357</ID>
          <LABEL>GSM3294357</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294357</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294358" accession="SRX4410073">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410073</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294358</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294358: Sult2B1b knock-down, Batch3 (015240_C10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563705">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563705</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294358</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294358</ID>
          <LABEL>GSM3294358</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294358</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294359" accession="SRX4410074">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410074</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294359</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294359: Sult2B1b knock-down, Batch3 (015241_D10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563709">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563709</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294359</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294359</ID>
          <LABEL>GSM3294359</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294359</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294360" accession="SRX4410075">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410075</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294360</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294360: Sult2B1b knock-down, Batch3 (015242_E10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563708">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563708</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294360</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294360</ID>
          <LABEL>GSM3294360</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294360</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294361" accession="SRX4410076">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410076</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294361</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294361: Sult2B1b knock-down, Batch3 (015243_F10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563710">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563710</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294361</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294361</ID>
          <LABEL>GSM3294361</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294361</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294362" accession="SRX4410077">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410077</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294362</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294362: Sult2B1b knock-down, Batch3 (015244_G10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563707">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563707</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294362</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294362</ID>
          <LABEL>GSM3294362</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294362</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294363" accession="SRX4410078">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410078</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294363</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294363: Sult2B1b knock-down, Batch3 (015245_H10); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563714">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563714</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294363</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294363</ID>
          <LABEL>GSM3294363</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294363</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294364" accession="SRX4410079">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410079</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294364</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294364: Sult2B1b knock-down, Batch3 (015246_A11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563712">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563712</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294364</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294364</ID>
          <LABEL>GSM3294364</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294364</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294365" accession="SRX4410080">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410080</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294365</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294365: Sult2B1b knock-down, Batch3 (015247_D11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563713">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563713</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294365</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294365</ID>
          <LABEL>GSM3294365</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294365</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294366" accession="SRX4410081">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410081</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294366</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294366: Sult2B1b knock-down, Batch3 (015248_F11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563711">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563711</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294366</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294366</ID>
          <LABEL>GSM3294366</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294366</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294367" accession="SRX4410082">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410082</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294367</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294367: Sult2B1b knock-down, Batch3 (015249_G11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563716">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563716</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294367</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294367</ID>
          <LABEL>GSM3294367</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294367</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294368" accession="SRX4410083">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410083</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294368</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294368: Sult2B1b knock-down, Batch3 (015250_H11); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563715">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563715</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294368</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294368</ID>
          <LABEL>GSM3294368</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294368</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294369" accession="SRX4410084">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410084</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294369</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294369: Sult2B1b knock-down, Batch3 (015251_A12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563718">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563718</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294369</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294369</ID>
          <LABEL>GSM3294369</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294369</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294370" accession="SRX4410085">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410085</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294370</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294370: Sult2B1b knock-down, Batch3 (015252_B12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563717">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563717</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294370</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294370</ID>
          <LABEL>GSM3294370</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294370</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294371" accession="SRX4410086">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410086</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294371</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294371: Sult2B1b knock-down, Batch3 (015253_C12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563720">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563720</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294371</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294371</ID>
          <LABEL>GSM3294371</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294371</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294372" accession="SRX4410087">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410087</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294372</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294372: Sult2B1b knock-down, Batch3 (015254_D12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563719">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563719</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294372</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294372</ID>
          <LABEL>GSM3294372</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294372</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294373" accession="SRX4410088">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410088</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294373</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294373: Sult2B1b knock-down, Batch3 (015255_E12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563721">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563721</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294373</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294373</ID>
          <LABEL>GSM3294373</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294373</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294374" accession="SRX4410089">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410089</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294374</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294374: Sult2B1b knock-down, Batch3 (015256_G12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563722">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563722</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294374</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294374</ID>
          <LABEL>GSM3294374</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294374</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294375" accession="SRX4410090">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410090</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294375</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294375: Sult2B1b knock-down, Batch3 (015257_H12); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563723">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563723</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294375</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294375</ID>
          <LABEL>GSM3294375</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294375</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294376" accession="SRX4410091">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410091</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294376</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294376: scrambled control, Batch3, multiple cell control (015258_3B-tube-control); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563726">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563726</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294376</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294376</ID>
          <LABEL>GSM3294376</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294376</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294377" accession="SRX4410092">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410092</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294377</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294377: Sult2B1b knockdown, Batch 1 repeated in Batch2 sequencing (015337_Sult2b1b-G12-repeat); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563724">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563724</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294377</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294377</ID>
          <LABEL>GSM3294377</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294377</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294378" accession="SRX4410093">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410093</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294378</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294378: Sult2B1b knockdown, Batch 1 repeated in Batch2 sequencing (015338_Sult2b1b-H12-repeat); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563725">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563725</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294378</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294378</ID>
          <LABEL>GSM3294378</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294378</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3294379" accession="SRX4410094">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX4410094</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3294379</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3294379: scrambled control, Batch 1 repeated in Batch2 sequencing (015339_Sult2b1b-control-repeat); Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP154483" refname="GSE117410">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP154483</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS3563727">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS3563727</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3294379</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Priming of the 17-25µm (large) IFC plate (Fluidigm, 100-5761) was completed according to the manufacturer's instructions.  Following priming, 15µL of cell mix was added to the IFC plate along with LIVE/DEAD cell staining solution containing 4µM ethidium homodimer-1 and calcein AM (Life Technologies, L-3224).  Cells were isolated and stained within the C1 system and then manually observed on an inverted fluorescence microscope with FITC and Texas Red filters (Olympus IX51). Capture sites containing 0 or &gt;1 cell were excluded, and cells with positive ethidium homodimer-1 staining were also excluded.  Cell lysis, reverse transcription, and cDNA amplification of single cells were conducted following the protocol for mRNA sequencing (Fluidigm). RNA sequencing by Illumina HiSeq2500 next generation sequencer</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303294379</ID>
          <LABEL>GSM3294379</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3294379</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
</EXPERIMENT_SET>
