SRX4559720 T2C for shSCR in MEL cells rep1 SRP158024 PRJNA486163 T2C was performed in duplicates as described (Kolovos et al., 2014, 2018). In brief, ~10 million cells were isolated, following cross-linking in 1% paraformaldehyde (10 min, 20C; Electron Microscopy Science), chromatin was cut using ApoI or HindIII (New England Biolabs), and ligated in dilution under conditions that allowed most nuclei to remain intact. SRS3676498 SAMN09842609 T2C for shSCR in MEL cells rep1 Tethered Chromatin Conformation Capture OTHER other Illumina HiSeq 2000 SRX4559721 T2C for shSCR in MEL cells rep2 SRP158024 PRJNA486163 T2C was performed in duplicates as described (Kolovos et al., 2014, 2018). In brief, ~10 million cells were isolated, following cross-linking in 1% paraformaldehyde (10 min, 20C; Electron Microscopy Science), chromatin was cut using ApoI or HindIII (New England Biolabs), and ligated in dilution under conditions that allowed most nuclei to remain intact. SRS3676498 SAMN09842609 T2C for shSCR in MEL cells rep2 Tethered Chromatin Conformation Capture OTHER other Illumina HiSeq 2000 SRX4559722 T2C in mouse fetal liver rep1 SRP158024 PRJNA486163 T2C was performed in duplicates as described (Kolovos et al., 2014, 2018). In brief, ~10 million cells were isolated, following cross-linking in 1% paraformaldehyde (10 min, 20C; Electron Microscopy Science), chromatin was cut using ApoI or HindIII (New England Biolabs), and ligated in dilution under conditions that allowed most nuclei to remain intact. SRS3676499 SAMN09842608 T2C in mouse fetal liver rep1 Tethered Chromatin Conformation Capture OTHER other Illumina HiSeq 2000 SRX4559723 T2C in mouse fetal liver rep2 SRP158024 PRJNA486163 T2C was performed in duplicates as described (Kolovos et al., 2014, 2018). In brief, ~10 million cells were isolated, following cross-linking in 1% paraformaldehyde (10 min, 20C; Electron Microscopy Science), chromatin was cut using ApoI or HindIII (New England Biolabs), and ligated in dilution under conditions that allowed most nuclei to remain intact. SRS3676499 SAMN09842608 T2C in mouse fetal liver rep2 Tethered Chromatin Conformation Capture OTHER other Illumina HiSeq 2000