SRX4634279 GSM3373932 SRP159458 SRS3734905 GSM3373932 RNA-Seq TRANSCRIPTOMIC cDNA The samples were processed directly using the SMARTer Ultra Low Input RNA for Illumina sequencing kit (Clontech Laboratories, Mountain View, CA, USA) to ensure minimum loss of cells. According to the manufacturer's suggested protocol, samples were collected in 2µl of DMEM-F12 + Glutamax (Invitrogen) with 25% bovine serum albumin (Sigma) and transferred to 5µl of pre-prepared reaction buffer. A final volume of 9µl was set up using nuclease-free water. The sample reaction mixture was then mixed with the first primer (3' SMART CDS primer II A) for first strand synthesis. This reaction mixture was placed in a thermocycler for 3 minutes and then incubated on ice. From this step, the first strand cDNA synthesis was set up directly using the SMARTScribe Reverse Transcriptase. Once completed, the first-strand cDNA was purified using SPRI Ampure beads, followed by double stranded (ds) cDNA amplification by long distance PCR. The amplified ds cDNA was then further purified using the Ampure beads. cDNA was fragmented in the 200-500bp range on a Covaris S2 Focused-ultrasonicator (Brighton, UK), according to the SMARTer Ultra Low Input RNA for Illumina sequencing protocol. A sequencing library was made using the Low Input Library Prep Kit (Clontech Laboratories, Mountain View, CA, USA). NextSeq 500 gds 303373932 GSM3373932 GEO Accession GSM3373932 SRX4634280 GSM3373933 SRP159458 SRS3734906 GSM3373933 RNA-Seq TRANSCRIPTOMIC cDNA The samples were processed directly using the SMARTer Ultra Low Input RNA for Illumina sequencing kit (Clontech Laboratories, Mountain View, CA, USA) to ensure minimum loss of cells. According to the manufacturer's suggested protocol, samples were collected in 2µl of DMEM-F12 + Glutamax (Invitrogen) with 25% bovine serum albumin (Sigma) and transferred to 5µl of pre-prepared reaction buffer. A final volume of 9µl was set up using nuclease-free water. The sample reaction mixture was then mixed with the first primer (3' SMART CDS primer II A) for first strand synthesis. This reaction mixture was placed in a thermocycler for 3 minutes and then incubated on ice. From this step, the first strand cDNA synthesis was set up directly using the SMARTScribe Reverse Transcriptase. Once completed, the first-strand cDNA was purified using SPRI Ampure beads, followed by double stranded (ds) cDNA amplification by long distance PCR. The amplified ds cDNA was then further purified using the Ampure beads. cDNA was fragmented in the 200-500bp range on a Covaris S2 Focused-ultrasonicator (Brighton, UK), according to the SMARTer Ultra Low Input RNA for Illumina sequencing protocol. A sequencing library was made using the Low Input Library Prep Kit (Clontech Laboratories, Mountain View, CA, USA). NextSeq 500 gds 303373933 GSM3373933 GEO Accession GSM3373933 SRX4634281 GSM3373934 SRP159458 SRS3734907 GSM3373934 RNA-Seq TRANSCRIPTOMIC cDNA The samples were processed directly using the SMARTer Ultra Low Input RNA for Illumina sequencing kit (Clontech Laboratories, Mountain View, CA, USA) to ensure minimum loss of cells. According to the manufacturer's suggested protocol, samples were collected in 2µl of DMEM-F12 + Glutamax (Invitrogen) with 25% bovine serum albumin (Sigma) and transferred to 5µl of pre-prepared reaction buffer. A final volume of 9µl was set up using nuclease-free water. The sample reaction mixture was then mixed with the first primer (3' SMART CDS primer II A) for first strand synthesis. This reaction mixture was placed in a thermocycler for 3 minutes and then incubated on ice. From this step, the first strand cDNA synthesis was set up directly using the SMARTScribe Reverse Transcriptase. Once completed, the first-strand cDNA was purified using SPRI Ampure beads, followed by double stranded (ds) cDNA amplification by long distance PCR. The amplified ds cDNA was then further purified using the Ampure beads. cDNA was fragmented in the 200-500bp range on a Covaris S2 Focused-ultrasonicator (Brighton, UK), according to the SMARTer Ultra Low Input RNA for Illumina sequencing protocol. A sequencing library was made using the Low Input Library Prep Kit (Clontech Laboratories, Mountain View, CA, USA). NextSeq 500 gds 303373934 GSM3373934 GEO Accession GSM3373934 SRX4634282 GSM3373935 SRP159458 SRS3734908 GSM3373935 RNA-Seq TRANSCRIPTOMIC cDNA The samples were processed directly using the SMARTer Ultra Low Input RNA for Illumina sequencing kit (Clontech Laboratories, Mountain View, CA, USA) to ensure minimum loss of cells. According to the manufacturer's suggested protocol, samples were collected in 2µl of DMEM-F12 + Glutamax (Invitrogen) with 25% bovine serum albumin (Sigma) and transferred to 5µl of pre-prepared reaction buffer. A final volume of 9µl was set up using nuclease-free water. The sample reaction mixture was then mixed with the first primer (3' SMART CDS primer II A) for first strand synthesis. This reaction mixture was placed in a thermocycler for 3 minutes and then incubated on ice. From this step, the first strand cDNA synthesis was set up directly using the SMARTScribe Reverse Transcriptase. Once completed, the first-strand cDNA was purified using SPRI Ampure beads, followed by double stranded (ds) cDNA amplification by long distance PCR. The amplified ds cDNA was then further purified using the Ampure beads. cDNA was fragmented in the 200-500bp range on a Covaris S2 Focused-ultrasonicator (Brighton, UK), according to the SMARTer Ultra Low Input RNA for Illumina sequencing protocol. A sequencing library was made using the Low Input Library Prep Kit (Clontech Laboratories, Mountain View, CA, USA). NextSeq 500 gds 303373935 GSM3373935 GEO Accession GSM3373935 SRX4634283 GSM3373936 SRP159458 SRS3734909 GSM3373936 RNA-Seq TRANSCRIPTOMIC cDNA The samples were processed directly using the SMARTer Ultra Low Input RNA for Illumina sequencing kit (Clontech Laboratories, Mountain View, CA, USA) to ensure minimum loss of cells. According to the manufacturer's suggested protocol, samples were collected in 2µl of DMEM-F12 + Glutamax (Invitrogen) with 25% bovine serum albumin (Sigma) and transferred to 5µl of pre-prepared reaction buffer. A final volume of 9µl was set up using nuclease-free water. The sample reaction mixture was then mixed with the first primer (3' SMART CDS primer II A) for first strand synthesis. This reaction mixture was placed in a thermocycler for 3 minutes and then incubated on ice. From this step, the first strand cDNA synthesis was set up directly using the SMARTScribe Reverse Transcriptase. Once completed, the first-strand cDNA was purified using SPRI Ampure beads, followed by double stranded (ds) cDNA amplification by long distance PCR. The amplified ds cDNA was then further purified using the Ampure beads. cDNA was fragmented in the 200-500bp range on a Covaris S2 Focused-ultrasonicator (Brighton, UK), according to the SMARTer Ultra Low Input RNA for Illumina sequencing protocol. A sequencing library was made using the Low Input Library Prep Kit (Clontech Laboratories, Mountain View, CA, USA). NextSeq 500 gds 303373936 GSM3373936 GEO Accession GSM3373936 SRX4634284 GSM3373937 SRP159458 SRS3734910 GSM3373937 RNA-Seq TRANSCRIPTOMIC cDNA The samples were processed directly using the SMARTer Ultra Low Input RNA for Illumina sequencing kit (Clontech Laboratories, Mountain View, CA, USA) to ensure minimum loss of cells. According to the manufacturer's suggested protocol, samples were collected in 2µl of DMEM-F12 + Glutamax (Invitrogen) with 25% bovine serum albumin (Sigma) and transferred to 5µl of pre-prepared reaction buffer. A final volume of 9µl was set up using nuclease-free water. The sample reaction mixture was then mixed with the first primer (3' SMART CDS primer II A) for first strand synthesis. This reaction mixture was placed in a thermocycler for 3 minutes and then incubated on ice. From this step, the first strand cDNA synthesis was set up directly using the SMARTScribe Reverse Transcriptase. Once completed, the first-strand cDNA was purified using SPRI Ampure beads, followed by double stranded (ds) cDNA amplification by long distance PCR. The amplified ds cDNA was then further purified using the Ampure beads. cDNA was fragmented in the 200-500bp range on a Covaris S2 Focused-ultrasonicator (Brighton, UK), according to the SMARTer Ultra Low Input RNA for Illumina sequencing protocol. A sequencing library was made using the Low Input Library Prep Kit (Clontech Laboratories, Mountain View, CA, USA). NextSeq 500 gds 303373937 GSM3373937 GEO Accession GSM3373937 SRX4634285 GSM3373938 SRP159458 SRS3734911 GSM3373938 RNA-Seq TRANSCRIPTOMIC cDNA The samples were processed directly using the SMARTer Ultra Low Input RNA for Illumina sequencing kit (Clontech Laboratories, Mountain View, CA, USA) to ensure minimum loss of cells. According to the manufacturer's suggested protocol, samples were collected in 2µl of DMEM-F12 + Glutamax (Invitrogen) with 25% bovine serum albumin (Sigma) and transferred to 5µl of pre-prepared reaction buffer. A final volume of 9µl was set up using nuclease-free water. The sample reaction mixture was then mixed with the first primer (3' SMART CDS primer II A) for first strand synthesis. This reaction mixture was placed in a thermocycler for 3 minutes and then incubated on ice. From this step, the first strand cDNA synthesis was set up directly using the SMARTScribe Reverse Transcriptase. Once completed, the first-strand cDNA was purified using SPRI Ampure beads, followed by double stranded (ds) cDNA amplification by long distance PCR. The amplified ds cDNA was then further purified using the Ampure beads. cDNA was fragmented in the 200-500bp range on a Covaris S2 Focused-ultrasonicator (Brighton, UK), according to the SMARTer Ultra Low Input RNA for Illumina sequencing protocol. A sequencing library was made using the Low Input Library Prep Kit (Clontech Laboratories, Mountain View, CA, USA). NextSeq 500 gds 303373938 GSM3373938 GEO Accession GSM3373938 SRX4634286 GSM3373939 SRP159458 SRS3734912 GSM3373939 RNA-Seq TRANSCRIPTOMIC cDNA The samples were processed directly using the SMARTer Ultra Low Input RNA for Illumina sequencing kit (Clontech Laboratories, Mountain View, CA, USA) to ensure minimum loss of cells. According to the manufacturer's suggested protocol, samples were collected in 2µl of DMEM-F12 + Glutamax (Invitrogen) with 25% bovine serum albumin (Sigma) and transferred to 5µl of pre-prepared reaction buffer. A final volume of 9µl was set up using nuclease-free water. The sample reaction mixture was then mixed with the first primer (3' SMART CDS primer II A) for first strand synthesis. This reaction mixture was placed in a thermocycler for 3 minutes and then incubated on ice. From this step, the first strand cDNA synthesis was set up directly using the SMARTScribe Reverse Transcriptase. Once completed, the first-strand cDNA was purified using SPRI Ampure beads, followed by double stranded (ds) cDNA amplification by long distance PCR. The amplified ds cDNA was then further purified using the Ampure beads. cDNA was fragmented in the 200-500bp range on a Covaris S2 Focused-ultrasonicator (Brighton, UK), according to the SMARTer Ultra Low Input RNA for Illumina sequencing protocol. A sequencing library was made using the Low Input Library Prep Kit (Clontech Laboratories, Mountain View, CA, USA). NextSeq 500 gds 303373939 GSM3373939 GEO Accession GSM3373939 SRX4634287 GSM3373940 SRP159458 SRS3734913 GSM3373940 RNA-Seq TRANSCRIPTOMIC cDNA The samples were processed directly using the SMARTer Ultra Low Input RNA for Illumina sequencing kit (Clontech Laboratories, Mountain View, CA, USA) to ensure minimum loss of cells. According to the manufacturer's suggested protocol, samples were collected in 2µl of DMEM-F12 + Glutamax (Invitrogen) with 25% bovine serum albumin (Sigma) and transferred to 5µl of pre-prepared reaction buffer. A final volume of 9µl was set up using nuclease-free water. The sample reaction mixture was then mixed with the first primer (3' SMART CDS primer II A) for first strand synthesis. This reaction mixture was placed in a thermocycler for 3 minutes and then incubated on ice. From this step, the first strand cDNA synthesis was set up directly using the SMARTScribe Reverse Transcriptase. Once completed, the first-strand cDNA was purified using SPRI Ampure beads, followed by double stranded (ds) cDNA amplification by long distance PCR. The amplified ds cDNA was then further purified using the Ampure beads. cDNA was fragmented in the 200-500bp range on a Covaris S2 Focused-ultrasonicator (Brighton, UK), according to the SMARTer Ultra Low Input RNA for Illumina sequencing protocol. A sequencing library was made using the Low Input Library Prep Kit (Clontech Laboratories, Mountain View, CA, USA). NextSeq 500 gds 303373940 GSM3373940 GEO Accession GSM3373940