SRP164745 PRJNA495144 Mucispirillum schaedleri protects mice against non-typhoidal Salmonella colitis The microbiota and host genotype determine susceptibility to enteric Salmonella enterica serovar Typhimurium (S. Tm) infection. In particular, the intestinal mucus layer plays an important role in innate immune defense. Using gnotobiotic mouse models, we identified Mucispirillum schaedleri to be causally involved in protection against S. Tm colitis.