<?xml version="1.0" encoding="UTF-8"?>
<EXPERIMENT_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <EXPERIMENT alias="GSM3502439" accession="SRX5099255">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX5099255</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3502439</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3502439: 746_WT_Shh_TSS_Rep1; Mus musculus; OTHER</TITLE>
    <STUDY_REF accession="SRP172675" refname="GSE123382">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP172675</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS4109625">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS4109625</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3502439</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>4C-seq libraries were prepared following the published protocol (van de Werken et al., 2012). DpnII was used for the first digestion, and Csp6I was used in the second digestion. For each viewpoint, a total of 1.6 mg of each library was amplified by PCR with the following primers: 4C_Shh_D/C_Read: CCATCCCCAGATGTGAGTGT,4C_Shh_D/C_Rev: CCATCGCAGCCCCAGTCT Samples were sequenced with Ilumina Hi-Seq technology according to standard procedures.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303502439</ID>
          <LABEL>GSM3502439</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3502439</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3502440" accession="SRX5099256">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX5099256</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3502440</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3502440: 747_WT_Shh_TSS_Rep2; Mus musculus; OTHER</TITLE>
    <STUDY_REF accession="SRP172675" refname="GSE123382">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP172675</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS4109626">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS4109626</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3502440</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>4C-seq libraries were prepared following the published protocol (van de Werken et al., 2012). DpnII was used for the first digestion, and Csp6I was used in the second digestion. For each viewpoint, a total of 1.6 mg of each library was amplified by PCR with the following primers: 4C_Shh_D/C_Read: CCATCCCCAGATGTGAGTGT,4C_Shh_D/C_Rev: CCATCGCAGCCCCAGTCT Samples were sequenced with Ilumina Hi-Seq technology according to standard procedures.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303502440</ID>
          <LABEL>GSM3502440</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3502440</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3502441" accession="SRX5099257">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX5099257</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3502441</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3502441: 748_Lmbr1Dprom_Shh TSS_Rep1; Mus musculus; OTHER</TITLE>
    <STUDY_REF accession="SRP172675" refname="GSE123382">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP172675</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS4109627">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS4109627</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3502441</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>4C-seq libraries were prepared following the published protocol (van de Werken et al., 2012). DpnII was used for the first digestion, and Csp6I was used in the second digestion. For each viewpoint, a total of 1.6 mg of each library was amplified by PCR with the following primers: 4C_Shh_D/C_Read: CCATCCCCAGATGTGAGTGT,4C_Shh_D/C_Rev: CCATCGCAGCCCCAGTCT Samples were sequenced with Ilumina Hi-Seq technology according to standard procedures.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303502441</ID>
          <LABEL>GSM3502441</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3502441</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3502442" accession="SRX5099258">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX5099258</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3502442</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3502442: 749_Lmbr1Dprom_Shh TSS_Rep2; Mus musculus; OTHER</TITLE>
    <STUDY_REF accession="SRP172675" refname="GSE123382">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP172675</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS4109628">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS4109628</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3502442</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>4C-seq libraries were prepared following the published protocol (van de Werken et al., 2012). DpnII was used for the first digestion, and Csp6I was used in the second digestion. For each viewpoint, a total of 1.6 mg of each library was amplified by PCR with the following primers: 4C_Shh_D/C_Read: CCATCCCCAGATGTGAGTGT,4C_Shh_D/C_Rev: CCATCGCAGCCCCAGTCT Samples were sequenced with Ilumina Hi-Seq technology according to standard procedures.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303502442</ID>
          <LABEL>GSM3502442</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3502442</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
</EXPERIMENT_SET>
