SRX5099803 GSM3502764 SRP172703 SRS4110138 GSM3502764 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502764 GSM3502764 GEO Accession GSM3502764 SRX5099804 GSM3502765 SRP172703 SRS4110139 GSM3502765 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502765 GSM3502765 GEO Accession GSM3502765 SRX5099805 GSM3502766 SRP172703 SRS4110140 GSM3502766 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502766 GSM3502766 GEO Accession GSM3502766 SRX5099806 GSM3502767 SRP172703 SRS4110141 GSM3502767 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502767 GSM3502767 GEO Accession GSM3502767 SRX5099807 GSM3502768 SRP172703 SRS4110142 GSM3502768 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502768 GSM3502768 GEO Accession GSM3502768 SRX5099808 GSM3502769 SRP172703 SRS4110143 GSM3502769 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502769 GSM3502769 GEO Accession GSM3502769 SRX5099809 GSM3502770 SRP172703 SRS4110144 GSM3502770 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502770 GSM3502770 GEO Accession GSM3502770 SRX5099810 GSM3502771 SRP172703 SRS4110145 GSM3502771 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502771 GSM3502771 GEO Accession GSM3502771 SRX5099811 GSM3502772 SRP172703 SRS4110146 GSM3502772 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502772 GSM3502772 GEO Accession GSM3502772 SRX5099812 GSM3502773 SRP172703 SRS4110147 GSM3502773 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502773 GSM3502773 GEO Accession GSM3502773 SRX5099813 GSM3502774 SRP172703 SRS4110148 GSM3502774 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502774 GSM3502774 GEO Accession GSM3502774 SRX5099814 GSM3502775 SRP172703 SRS4110149 GSM3502775 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502775 GSM3502775 GEO Accession GSM3502775 SRX5099815 GSM3502776 SRP172703 SRS4110150 GSM3502776 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502776 GSM3502776 GEO Accession GSM3502776 SRX5099816 GSM3502777 SRP172703 SRS4110151 GSM3502777 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502777 GSM3502777 GEO Accession GSM3502777 SRX5099817 GSM3502778 SRP172703 SRS4110152 GSM3502778 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502778 GSM3502778 GEO Accession GSM3502778 SRX5099818 GSM3502779 SRP172703 SRS4110153 GSM3502779 RNA-Seq TRANSCRIPTOMIC cDNA RNA was isolated using Trizol and glass bead lysis after which RNA was precipitated and DNase treated followed by a column purification step. 5μg DNase-treated total RNA was subjected to mRNA purification using Dynabeads mRNA purification kit (Invitrogen). Remaining rRNA contamination was checked in the bioanalyzer using Agilent RNA 6000 Pico kit (Agilent). Purified mRNA was subjected to fragmentation using the NEBNext® Magnesium RNA Fragmentation Module (New England Biolabs) and purified with RNeasy Plus Mini kit (Qiagen). Then, first-strand cDNA was synthesized with 50 ng/μl random hexamer primers using SuperScript ® III First-Strand Synthesis System for RT-PCR (Invitrogen). dNTPs were eliminated by purifying with MiniQuickSpin DNA Columns and subjected to second strand cDNA synthesis followed by clean-up with Minielute Reaction cleanup kit (Qiagen). cDNA concentration was measured using Quant-iT Picogreen dsDNA Reagents (Invitrogen) in a NanoDrop Fluorospectrophotometer ND-3300 (Thermo Fisher). Library preparation was done using the KAPA DNA Library Preparation Kit (Kapa Biosystems) according to the manufacturer's instructions. Illumina HiSeq 2500 gds 303502779 GSM3502779 GEO Accession GSM3502779