SRX5101233 GSM3503285 SRP172752 SRS4111515 GSM3503285 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from the ventricular tissue of heterozygous RE6-9 mice and wildtype littermates using Tri Reagent (Sigma Aldrich) according to the manufacturer's protocol (Sigma Aldrich) and further purified using Nucleospin RNA Clean-up Kit with DnaseI treatment (Macherey-Nagel) cDNA was prepared with the Truseq Stranded Total RNA Library Preparation Kit (Illumina, Part# 15031048 Rev. E). Total RNA (1 µg) was purified and sheared into small fragments followed by cDNA synthesis and ligation of the adapter. The quality and size distribution of the cDNA library templates were validated with Agilent DNA 1000 on 2100 Bioanalyzer (Agilent Technologies). cDNA samples were pooled per lane of paired-end 125 bp sequencing on an Illumina HiSeq 2500 instrument. Illumina HiSeq 2500 gds 303503285 GSM3503285 GEO Accession GSM3503285 SRX5101234 GSM3503286 SRP172752 SRS4111516 GSM3503286 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from the ventricular tissue of heterozygous RE6-9 mice and wildtype littermates using Tri Reagent (Sigma Aldrich) according to the manufacturer's protocol (Sigma Aldrich) and further purified using Nucleospin RNA Clean-up Kit with DnaseI treatment (Macherey-Nagel) cDNA was prepared with the Truseq Stranded Total RNA Library Preparation Kit (Illumina, Part# 15031048 Rev. E). Total RNA (1 µg) was purified and sheared into small fragments followed by cDNA synthesis and ligation of the adapter. The quality and size distribution of the cDNA library templates were validated with Agilent DNA 1000 on 2100 Bioanalyzer (Agilent Technologies). cDNA samples were pooled per lane of paired-end 125 bp sequencing on an Illumina HiSeq 2500 instrument. Illumina HiSeq 2500 gds 303503286 GSM3503286 GEO Accession GSM3503286 SRX5101235 GSM3503287 SRP172752 SRS4111517 GSM3503287 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from the ventricular tissue of heterozygous RE6-9 mice and wildtype littermates using Tri Reagent (Sigma Aldrich) according to the manufacturer's protocol (Sigma Aldrich) and further purified using Nucleospin RNA Clean-up Kit with DnaseI treatment (Macherey-Nagel) cDNA was prepared with the Truseq Stranded Total RNA Library Preparation Kit (Illumina, Part# 15031048 Rev. E). Total RNA (1 µg) was purified and sheared into small fragments followed by cDNA synthesis and ligation of the adapter. The quality and size distribution of the cDNA library templates were validated with Agilent DNA 1000 on 2100 Bioanalyzer (Agilent Technologies). cDNA samples were pooled per lane of paired-end 125 bp sequencing on an Illumina HiSeq 2500 instrument. Illumina HiSeq 2500 gds 303503287 GSM3503287 GEO Accession GSM3503287 SRX5101236 GSM3503288 SRP172752 SRS4111518 GSM3503288 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from the ventricular tissue of heterozygous RE6-9 mice and wildtype littermates using Tri Reagent (Sigma Aldrich) according to the manufacturer's protocol (Sigma Aldrich) and further purified using Nucleospin RNA Clean-up Kit with DnaseI treatment (Macherey-Nagel) cDNA was prepared with the Truseq Stranded Total RNA Library Preparation Kit (Illumina, Part# 15031048 Rev. E). Total RNA (1 µg) was purified and sheared into small fragments followed by cDNA synthesis and ligation of the adapter. The quality and size distribution of the cDNA library templates were validated with Agilent DNA 1000 on 2100 Bioanalyzer (Agilent Technologies). cDNA samples were pooled per lane of paired-end 125 bp sequencing on an Illumina HiSeq 2500 instrument. Illumina HiSeq 2500 gds 303503288 GSM3503288 GEO Accession GSM3503288 SRX5101237 GSM3503289 SRP172752 SRS4111519 GSM3503289 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from the ventricular tissue of heterozygous RE6-9 mice and wildtype littermates using Tri Reagent (Sigma Aldrich) according to the manufacturer's protocol (Sigma Aldrich) and further purified using Nucleospin RNA Clean-up Kit with DnaseI treatment (Macherey-Nagel) cDNA was prepared with the Truseq Stranded Total RNA Library Preparation Kit (Illumina, Part# 15031048 Rev. E). Total RNA (1 µg) was purified and sheared into small fragments followed by cDNA synthesis and ligation of the adapter. The quality and size distribution of the cDNA library templates were validated with Agilent DNA 1000 on 2100 Bioanalyzer (Agilent Technologies). cDNA samples were pooled per lane of paired-end 125 bp sequencing on an Illumina HiSeq 2500 instrument. Illumina HiSeq 2500 gds 303503289 GSM3503289 GEO Accession GSM3503289 SRX5101238 GSM3503290 SRP172752 SRS4111520 GSM3503290 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated from the ventricular tissue of heterozygous RE6-9 mice and wildtype littermates using Tri Reagent (Sigma Aldrich) according to the manufacturer's protocol (Sigma Aldrich) and further purified using Nucleospin RNA Clean-up Kit with DnaseI treatment (Macherey-Nagel) cDNA was prepared with the Truseq Stranded Total RNA Library Preparation Kit (Illumina, Part# 15031048 Rev. E). Total RNA (1 µg) was purified and sheared into small fragments followed by cDNA synthesis and ligation of the adapter. The quality and size distribution of the cDNA library templates were validated with Agilent DNA 1000 on 2100 Bioanalyzer (Agilent Technologies). cDNA samples were pooled per lane of paired-end 125 bp sequencing on an Illumina HiSeq 2500 instrument. Illumina HiSeq 2500 gds 303503290 GSM3503290 GEO Accession GSM3503290