<?xml version="1.0" encoding="UTF-8"?>
<EXPERIMENT_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <EXPERIMENT alias="GSM3504643" accession="SRX5104221">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX5104221</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3504643</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3504643: X1 [RNA-seq]; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP172793">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP172793</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA508813</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS4113971">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS4113971</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN10531268</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from TAMs or TAM EVs using RNeasy mini kit (Qiagen, Germany) or SeraMir Exosome RNA Purification for Media &amp; Urine (RA806TC-1, System Biosciences, USA). According to the experimental instructions, the purified total RNA was subjected to rRNA isolation, fragmentation, first strand cDNA synthesis, second strand cDNA synthesis, terminal repair, 3' end plus A, ligation linker, enrichment and other steps to complete the library construction of the samples.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>HiSeq X Ten</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303504643</ID>
          <LABEL>GSM3504643</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3504643</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3504644" accession="SRX5104222">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX5104222</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3504644</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3504644: X3hao [RNA-seq]; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP172793">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP172793</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA508813</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS4113972">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS4113972</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN10531267</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Total RNA was isolated from TAMs or TAM EVs using RNeasy mini kit (Qiagen, Germany) or SeraMir Exosome RNA Purification for Media &amp; Urine (RA806TC-1, System Biosciences, USA). According to the experimental instructions, the purified total RNA was subjected to rRNA isolation, fragmentation, first strand cDNA synthesis, second strand cDNA synthesis, terminal repair, 3' end plus A, ligation linker, enrichment and other steps to complete the library construction of the samples.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>HiSeq X Ten</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303504644</ID>
          <LABEL>GSM3504644</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3504644</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
</EXPERIMENT_SET>
