SRX5183155 GSM3532120 SRP174544 SRS4189948 GSM3532120 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 303532120 GSM3532120 GEO Accession GSM3532120 SRX5183156 GSM3532121 SRP174544 SRS4189949 GSM3532121 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 303532121 GSM3532121 GEO Accession GSM3532121 SRX5183157 GSM3532122 SRP174544 SRS4189950 GSM3532122 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 303532122 GSM3532122 GEO Accession GSM3532122 SRX5183158 GSM3532123 SRP174544 SRS4189951 GSM3532123 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 303532123 GSM3532123 GEO Accession GSM3532123 SRX5183159 GSM3532124 SRP174544 SRS4189952 GSM3532124 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 303532124 GSM3532124 GEO Accession GSM3532124 SRX5183160 GSM3532125 SRP174544 SRS4189954 GSM3532125 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 303532125 GSM3532125 GEO Accession GSM3532125 SRX7405759 GSM4223708 SRP174544 PRJNA511965 SRS5853031 GSM4223708 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 304223708 GSM4223708 GEO Accession GSM4223708 SRX7405760 GSM4223709 SRP174544 PRJNA511965 SRS5853032 GSM4223709 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 304223709 GSM4223709 GEO Accession GSM4223709 SRX7405761 GSM4223710 SRP174544 PRJNA511965 SRS5853033 GSM4223710 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 304223710 GSM4223710 GEO Accession GSM4223710 SRX7405762 GSM4223711 SRP174544 PRJNA511965 SRS5853035 GSM4223711 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 304223711 GSM4223711 GEO Accession GSM4223711 SRX7405763 GSM4223712 SRP174544 PRJNA511965 SRS5853040 GSM4223712 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 304223712 GSM4223712 GEO Accession GSM4223712 SRX7405764 GSM4223713 SRP174544 PRJNA511965 SRS5853036 GSM4223713 RNA-Seq TRANSCRIPTOMIC cDNA The cells were harvested by centrifugation, and the total RNA was isolated using a RNeasy Plus Mini kit (QIAGEN) following the instruction manual. Five microgram of total RNA was treated using a GeneRead rRNA Depletion kit (Qiagen) for remove Ribosomal RNA (rRNA) and an RNeasy MiniElute kit (Qiagen) for cleanup. One hundred ng of rRNA-depleted RNA was incubated at 95 ºC for 10 min for fragmentation and was purified by Magnetic Beads Cleanup Module (Life Technologies). The libraries were constructed using Ion Total RNA-seq kit for AB Libraly builer system (Thermo Fisher Scientific Inc.) and were barcoded with Ion Xpress RNA-seq BC primer ((Thermo Fisher Scientific Inc., 16 PCR cycles). Barcoded library fragment with the size range of 100-200 bp was selected with Agencourt AMPure XP beads (Beckman Coulter, Brea, CA). Templates were prepared using Ion PI Hi-Q Chef Kit (Thermo Fisher Scientific Inc.) on Ion Chef (Thermo Fisher Scientific Inc.). Sequencing was performed on an Ion Proton system by the P1 chip v3 (Thermo Fisher Scientific Inc.) using Hi-Q Sequensing kit (Thermo Fisher Scientific Inc.). Ion Torrent Proton gds 304223713 GSM4223713 GEO Accession GSM4223713