SRX5214058 GSM3544110 SRP176459 SRS4218090 GSM3544110 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544110 GSM3544110 GEO Accession GSM3544110 SRX5214059 GSM3544111 SRP176459 SRS4218091 GSM3544111 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544111 GSM3544111 GEO Accession GSM3544111 SRX5214060 GSM3544112 SRP176459 SRS4218092 GSM3544112 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544112 GSM3544112 GEO Accession GSM3544112 SRX5214061 GSM3544113 SRP176459 SRS4218093 GSM3544113 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544113 GSM3544113 GEO Accession GSM3544113 SRX5214062 GSM3544114 SRP176459 SRS4218094 GSM3544114 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544114 GSM3544114 GEO Accession GSM3544114 SRX5214063 GSM3544115 SRP176459 SRS4218095 GSM3544115 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544115 GSM3544115 GEO Accession GSM3544115 SRX5214064 GSM3544116 SRP176459 SRS4218096 GSM3544116 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544116 GSM3544116 GEO Accession GSM3544116 SRX5214065 GSM3544117 SRP176459 SRS4218097 GSM3544117 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544117 GSM3544117 GEO Accession GSM3544117 SRX5214066 GSM3544118 SRP176459 SRS4218098 GSM3544118 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544118 GSM3544118 GEO Accession GSM3544118 SRX5214067 GSM3544119 SRP176459 SRS4218099 GSM3544119 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544119 GSM3544119 GEO Accession GSM3544119 SRX5214068 GSM3544120 SRP176459 SRS4218100 GSM3544120 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544120 GSM3544120 GEO Accession GSM3544120 SRX5214069 GSM3544121 SRP176459 SRS4218101 GSM3544121 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544121 GSM3544121 GEO Accession GSM3544121 SRX5214070 GSM3544122 SRP176459 SRS4218102 GSM3544122 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544122 GSM3544122 GEO Accession GSM3544122 SRX5214071 GSM3544123 SRP176459 SRS4218103 GSM3544123 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544123 GSM3544123 GEO Accession GSM3544123 SRX5214072 GSM3544124 SRP176459 SRS4218104 GSM3544124 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544124 GSM3544124 GEO Accession GSM3544124 SRX5214073 GSM3544125 SRP176459 SRS4218105 GSM3544125 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544125 GSM3544125 GEO Accession GSM3544125 SRX5214074 GSM3544158 SRP176459 SRS4218106 GSM3544158 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544158 GSM3544158 GEO Accession GSM3544158 SRX5214075 GSM3544159 SRP176459 SRS4218107 GSM3544159 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544159 GSM3544159 GEO Accession GSM3544159 SRX5214076 GSM3544160 SRP176459 SRS4218108 GSM3544160 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544160 GSM3544160 GEO Accession GSM3544160 SRX5214077 GSM3544161 SRP176459 SRS4218109 GSM3544161 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544161 GSM3544161 GEO Accession GSM3544161 SRX5214078 GSM3544162 SRP176459 SRS4218110 GSM3544162 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544162 GSM3544162 GEO Accession GSM3544162 SRX5214079 GSM3544163 SRP176459 SRS4218111 GSM3544163 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544163 GSM3544163 GEO Accession GSM3544163 SRX5214080 GSM3544164 SRP176459 SRS4218112 GSM3544164 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544164 GSM3544164 GEO Accession GSM3544164 SRX5214081 GSM3544165 SRP176459 SRS4218113 GSM3544165 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544165 GSM3544165 GEO Accession GSM3544165 SRX5214082 GSM3544166 SRP176459 SRS4218114 GSM3544166 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544166 GSM3544166 GEO Accession GSM3544166 SRX5214083 GSM3544167 SRP176459 SRS4218115 GSM3544167 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544167 GSM3544167 GEO Accession GSM3544167 SRX5214084 GSM3544168 SRP176459 SRS4218116 GSM3544168 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544168 GSM3544168 GEO Accession GSM3544168 SRX5214085 GSM3544169 SRP176459 SRS4218117 GSM3544169 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544169 GSM3544169 GEO Accession GSM3544169 SRX5214086 GSM3544170 SRP176459 SRS4218118 GSM3544170 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544170 GSM3544170 GEO Accession GSM3544170 SRX5214087 GSM3544171 SRP176459 SRS4218119 GSM3544171 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544171 GSM3544171 GEO Accession GSM3544171 SRX5214088 GSM3544172 SRP176459 SRS4218120 GSM3544172 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544172 GSM3544172 GEO Accession GSM3544172 SRX5214089 GSM3544173 SRP176459 SRS4218121 GSM3544173 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544173 GSM3544173 GEO Accession GSM3544173 SRX5214090 GSM3544174 SRP176459 SRS4218122 GSM3544174 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544174 GSM3544174 GEO Accession GSM3544174 SRX5214091 GSM3544175 SRP176459 SRS4218123 GSM3544175 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544175 GSM3544175 GEO Accession GSM3544175 SRX5214092 GSM3544176 SRP176459 SRS4218124 GSM3544176 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544176 GSM3544176 GEO Accession GSM3544176 SRX5214093 GSM3544177 SRP176459 SRS4218125 GSM3544177 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544177 GSM3544177 GEO Accession GSM3544177 SRX5214094 GSM3544178 SRP176459 SRS4218126 GSM3544178 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544178 GSM3544178 GEO Accession GSM3544178 SRX5214095 GSM3544179 SRP176459 SRS4218127 GSM3544179 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544179 GSM3544179 GEO Accession GSM3544179 SRX5214096 GSM3544180 SRP176459 SRS4218128 GSM3544180 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544180 GSM3544180 GEO Accession GSM3544180 SRX5214097 GSM3544181 SRP176459 SRS4218129 GSM3544181 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544181 GSM3544181 GEO Accession GSM3544181 SRX5214098 GSM3544182 SRP176459 SRS4218130 GSM3544182 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544182 GSM3544182 GEO Accession GSM3544182 SRX5214099 GSM3544183 SRP176459 SRS4218131 GSM3544183 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544183 GSM3544183 GEO Accession GSM3544183 SRX5214100 GSM3544184 SRP176459 SRS4218132 GSM3544184 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544184 GSM3544184 GEO Accession GSM3544184 SRX5214101 GSM3544185 SRP176459 SRS4218133 GSM3544185 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544185 GSM3544185 GEO Accession GSM3544185 SRX5214102 GSM3544186 SRP176459 SRS4218134 GSM3544186 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544186 GSM3544186 GEO Accession GSM3544186 SRX5214103 GSM3544187 SRP176459 SRS4218135 GSM3544187 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544187 GSM3544187 GEO Accession GSM3544187 SRX5214104 GSM3544188 SRP176459 SRS4218136 GSM3544188 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544188 GSM3544188 GEO Accession GSM3544188 SRX5214105 GSM3544189 SRP176459 SRS4218137 GSM3544189 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544189 GSM3544189 GEO Accession GSM3544189 SRX5214106 GSM3544190 SRP176459 SRS4218138 GSM3544190 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544190 GSM3544190 GEO Accession GSM3544190 SRX5214107 GSM3544191 SRP176459 SRS4218139 GSM3544191 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544191 GSM3544191 GEO Accession GSM3544191 SRX5214108 GSM3544192 SRP176459 SRS4218140 GSM3544192 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544192 GSM3544192 GEO Accession GSM3544192 SRX5214109 GSM3544193 SRP176459 SRS4218141 GSM3544193 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544193 GSM3544193 GEO Accession GSM3544193 SRX5214110 GSM3544194 SRP176459 SRS4218142 GSM3544194 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544194 GSM3544194 GEO Accession GSM3544194 SRX5214111 GSM3544195 SRP176459 SRS4218143 GSM3544195 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544195 GSM3544195 GEO Accession GSM3544195 SRX5214112 GSM3544196 SRP176459 SRS4218144 GSM3544196 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544196 GSM3544196 GEO Accession GSM3544196 SRX5214113 GSM3544197 SRP176459 SRS4218145 GSM3544197 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544197 GSM3544197 GEO Accession GSM3544197 SRX5214114 GSM3544198 SRP176459 SRS4218146 GSM3544198 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544198 GSM3544198 GEO Accession GSM3544198 SRX5214115 GSM3544199 SRP176459 SRS4218147 GSM3544199 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544199 GSM3544199 GEO Accession GSM3544199 SRX5214116 GSM3544200 SRP176459 SRS4218148 GSM3544200 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544200 GSM3544200 GEO Accession GSM3544200 SRX5214117 GSM3544201 SRP176459 SRS4218149 GSM3544201 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544201 GSM3544201 GEO Accession GSM3544201 SRX5214118 GSM3544202 SRP176459 SRS4218150 GSM3544202 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544202 GSM3544202 GEO Accession GSM3544202 SRX5214119 GSM3544203 SRP176459 SRS4218151 GSM3544203 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544203 GSM3544203 GEO Accession GSM3544203 SRX5214120 GSM3544204 SRP176459 SRS4218152 GSM3544204 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544204 GSM3544204 GEO Accession GSM3544204 SRX5214121 GSM3544205 SRP176459 SRS4218153 GSM3544205 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544205 GSM3544205 GEO Accession GSM3544205 SRX5214122 GSM3544206 SRP176459 SRS4218154 GSM3544206 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544206 GSM3544206 GEO Accession GSM3544206 SRX5214123 GSM3544207 SRP176459 SRS4218155 GSM3544207 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544207 GSM3544207 GEO Accession GSM3544207 SRX5214124 GSM3544208 SRP176459 SRS4218156 GSM3544208 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544208 GSM3544208 GEO Accession GSM3544208 SRX5214125 GSM3544209 SRP176459 SRS4218157 GSM3544209 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544209 GSM3544209 GEO Accession GSM3544209 SRX5214126 GSM3544210 SRP176459 SRS4218158 GSM3544210 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544210 GSM3544210 GEO Accession GSM3544210 SRX5214127 GSM3544211 SRP176459 SRS4218159 GSM3544211 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544211 GSM3544211 GEO Accession GSM3544211 SRX5214128 GSM3544212 SRP176459 SRS4218160 GSM3544212 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544212 GSM3544212 GEO Accession GSM3544212 SRX5214129 GSM3544213 SRP176459 SRS4218161 GSM3544213 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544213 GSM3544213 GEO Accession GSM3544213 SRX5214130 GSM3544214 SRP176459 SRS4218162 GSM3544214 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544214 GSM3544214 GEO Accession GSM3544214 SRX5214131 GSM3544215 SRP176459 SRS4218163 GSM3544215 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544215 GSM3544215 GEO Accession GSM3544215 SRX5214132 GSM3544216 SRP176459 SRS4218164 GSM3544216 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544216 GSM3544216 GEO Accession GSM3544216 SRX5214133 GSM3544217 SRP176459 SRS4218165 GSM3544217 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. NextSeq 500 gds 303544217 GSM3544217 GEO Accession GSM3544217 SRX5214134 GSM3544218 SRP176459 SRS4218166 GSM3544218 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544218 GSM3544218 GEO Accession GSM3544218 SRX5214135 GSM3544219 SRP176459 SRS4218167 GSM3544219 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544219 GSM3544219 GEO Accession GSM3544219 SRX5214136 GSM3544220 SRP176459 SRS4218168 GSM3544220 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544220 GSM3544220 GEO Accession GSM3544220 SRX5214137 GSM3544221 SRP176459 SRS4218169 GSM3544221 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544221 GSM3544221 GEO Accession GSM3544221 SRX5214138 GSM3544222 SRP176459 SRS4218170 GSM3544222 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544222 GSM3544222 GEO Accession GSM3544222 SRX5214139 GSM3544223 SRP176459 SRS4218171 GSM3544223 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544223 GSM3544223 GEO Accession GSM3544223 SRX5214140 GSM3544224 SRP176459 SRS4218172 GSM3544224 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544224 GSM3544224 GEO Accession GSM3544224 SRX5214141 GSM3544225 SRP176459 SRS4218173 GSM3544225 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544225 GSM3544225 GEO Accession GSM3544225 SRX5214142 GSM3544226 SRP176459 SRS4218174 GSM3544226 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544226 GSM3544226 GEO Accession GSM3544226 SRX5214143 GSM3544227 SRP176459 SRS4218175 GSM3544227 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544227 GSM3544227 GEO Accession GSM3544227 SRX5214144 GSM3544228 SRP176459 SRS4218176 GSM3544228 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544228 GSM3544228 GEO Accession GSM3544228 SRX5214145 GSM3544229 SRP176459 SRS4218177 GSM3544229 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544229 GSM3544229 GEO Accession GSM3544229 SRX5214146 GSM3544230 SRP176459 SRS4218178 GSM3544230 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544230 GSM3544230 GEO Accession GSM3544230 SRX5214147 GSM3544231 SRP176459 SRS4218179 GSM3544231 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544231 GSM3544231 GEO Accession GSM3544231 SRX5214148 GSM3544232 SRP176459 SRS4218180 GSM3544232 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544232 GSM3544232 GEO Accession GSM3544232 SRX5214149 GSM3544233 SRP176459 SRS4218181 GSM3544233 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544233 GSM3544233 GEO Accession GSM3544233 SRX5214150 GSM3544234 SRP176459 SRS4218182 GSM3544234 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544234 GSM3544234 GEO Accession GSM3544234 SRX5214151 GSM3544235 SRP176459 SRS4218183 GSM3544235 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544235 GSM3544235 GEO Accession GSM3544235 SRX5214152 GSM3544236 SRP176459 SRS4218184 GSM3544236 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544236 GSM3544236 GEO Accession GSM3544236 SRX5214153 GSM3544237 SRP176459 SRS4218185 GSM3544237 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544237 GSM3544237 GEO Accession GSM3544237 SRX5214154 GSM3544238 SRP176459 SRS4218186 GSM3544238 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544238 GSM3544238 GEO Accession GSM3544238 SRX5214155 GSM3544239 SRP176459 SRS4218187 GSM3544239 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544239 GSM3544239 GEO Accession GSM3544239 SRX5214156 GSM3544240 SRP176459 SRS4218188 GSM3544240 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544240 GSM3544240 GEO Accession GSM3544240 SRX5214157 GSM3544241 SRP176459 SRS4218189 GSM3544241 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544241 GSM3544241 GEO Accession GSM3544241 SRX5214158 GSM3544242 SRP176459 SRS4218190 GSM3544242 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544242 GSM3544242 GEO Accession GSM3544242 SRX5214159 GSM3544243 SRP176459 SRS4218191 GSM3544243 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544243 GSM3544243 GEO Accession GSM3544243 SRX5214160 GSM3544244 SRP176459 SRS4218192 GSM3544244 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544244 GSM3544244 GEO Accession GSM3544244 SRX5214161 GSM3544245 SRP176459 SRS4218193 GSM3544245 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544245 GSM3544245 GEO Accession GSM3544245 SRX5214162 GSM3544246 SRP176459 SRS4218194 GSM3544246 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544246 GSM3544246 GEO Accession GSM3544246 SRX5214163 GSM3544247 SRP176459 SRS4218195 GSM3544247 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544247 GSM3544247 GEO Accession GSM3544247 SRX5214164 GSM3544248 SRP176459 SRS4218196 GSM3544248 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544248 GSM3544248 GEO Accession GSM3544248 SRX5214165 GSM3544249 SRP176459 SRS4218197 GSM3544249 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544249 GSM3544249 GEO Accession GSM3544249 SRX5214166 GSM3544250 SRP176459 SRS4218198 GSM3544250 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544250 GSM3544250 GEO Accession GSM3544250 SRX5214167 GSM3544251 SRP176459 SRS4218199 GSM3544251 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544251 GSM3544251 GEO Accession GSM3544251 SRX5214168 GSM3544252 SRP176459 SRS4218200 GSM3544252 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544252 GSM3544252 GEO Accession GSM3544252 SRX5214169 GSM3544253 SRP176459 SRS4218201 GSM3544253 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544253 GSM3544253 GEO Accession GSM3544253 SRX5214170 GSM3544126 SRP176459 SRS4218202 GSM3544126 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544126 GSM3544126 GEO Accession GSM3544126 SRX5214171 GSM3544127 SRP176459 SRS4218203 GSM3544127 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544127 GSM3544127 GEO Accession GSM3544127 SRX5214172 GSM3544128 SRP176459 SRS4218204 GSM3544128 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544128 GSM3544128 GEO Accession GSM3544128 SRX5214173 GSM3544129 SRP176459 SRS4218205 GSM3544129 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544129 GSM3544129 GEO Accession GSM3544129 SRX5214174 GSM3544130 SRP176459 SRS4218206 GSM3544130 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544130 GSM3544130 GEO Accession GSM3544130 SRX5214175 GSM3544131 SRP176459 SRS4218207 GSM3544131 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544131 GSM3544131 GEO Accession GSM3544131 SRX5214176 GSM3544132 SRP176459 SRS4218208 GSM3544132 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544132 GSM3544132 GEO Accession GSM3544132 SRX5214177 GSM3544133 SRP176459 SRS4218209 GSM3544133 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544133 GSM3544133 GEO Accession GSM3544133 SRX5214178 GSM3544134 SRP176459 SRS4218210 GSM3544134 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544134 GSM3544134 GEO Accession GSM3544134 SRX5214179 GSM3544135 SRP176459 SRS4218211 GSM3544135 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544135 GSM3544135 GEO Accession GSM3544135 SRX5214180 GSM3544136 SRP176459 SRS4218212 GSM3544136 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544136 GSM3544136 GEO Accession GSM3544136 SRX5214181 GSM3544137 SRP176459 SRS4218213 GSM3544137 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544137 GSM3544137 GEO Accession GSM3544137 SRX5214182 GSM3544138 SRP176459 SRS4218214 GSM3544138 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544138 GSM3544138 GEO Accession GSM3544138 SRX5214183 GSM3544139 SRP176459 SRS4218215 GSM3544139 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544139 GSM3544139 GEO Accession GSM3544139 SRX5214184 GSM3544140 SRP176459 SRS4218216 GSM3544140 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544140 GSM3544140 GEO Accession GSM3544140 SRX5214185 GSM3544141 SRP176459 SRS4218217 GSM3544141 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544141 GSM3544141 GEO Accession GSM3544141 SRX5214186 GSM3544254 SRP176459 SRS4218218 GSM3544254 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544254 GSM3544254 GEO Accession GSM3544254 SRX5214187 GSM3544255 SRP176459 SRS4218219 GSM3544255 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544255 GSM3544255 GEO Accession GSM3544255 SRX5214188 GSM3544256 SRP176459 SRS4218220 GSM3544256 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544256 GSM3544256 GEO Accession GSM3544256 SRX5214189 GSM3544257 SRP176459 SRS4218221 GSM3544257 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544257 GSM3544257 GEO Accession GSM3544257 SRX5214190 GSM3544258 SRP176459 SRS4218222 GSM3544258 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544258 GSM3544258 GEO Accession GSM3544258 SRX5214191 GSM3544259 SRP176459 SRS4218223 GSM3544259 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544259 GSM3544259 GEO Accession GSM3544259 SRX5214192 GSM3544260 SRP176459 SRS4218224 GSM3544260 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544260 GSM3544260 GEO Accession GSM3544260 SRX5214193 GSM3544261 SRP176459 SRS4218225 GSM3544261 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544261 GSM3544261 GEO Accession GSM3544261 SRX5214194 GSM3544262 SRP176459 SRS4218226 GSM3544262 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544262 GSM3544262 GEO Accession GSM3544262 SRX5214195 GSM3544263 SRP176459 SRS4218227 GSM3544263 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544263 GSM3544263 GEO Accession GSM3544263 SRX5214196 GSM3544264 SRP176459 SRS4218228 GSM3544264 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544264 GSM3544264 GEO Accession GSM3544264 SRX5214197 GSM3544265 SRP176459 SRS4218229 GSM3544265 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544265 GSM3544265 GEO Accession GSM3544265 SRX5214198 GSM3544266 SRP176459 SRS4218230 GSM3544266 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544266 GSM3544266 GEO Accession GSM3544266 SRX5214199 GSM3544267 SRP176459 SRS4218231 GSM3544267 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544267 GSM3544267 GEO Accession GSM3544267 SRX5214200 GSM3544268 SRP176459 SRS4218232 GSM3544268 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544268 GSM3544268 GEO Accession GSM3544268 SRX5214201 GSM3544269 SRP176459 SRS4218233 GSM3544269 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544269 GSM3544269 GEO Accession GSM3544269 SRX5214202 GSM3544142 SRP176459 SRS4218234 GSM3544142 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544142 GSM3544142 GEO Accession GSM3544142 SRX5214203 GSM3544143 SRP176459 SRS4218235 GSM3544143 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544143 GSM3544143 GEO Accession GSM3544143 SRX5214204 GSM3544144 SRP176459 SRS4218236 GSM3544144 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544144 GSM3544144 GEO Accession GSM3544144 SRX5214205 GSM3544145 SRP176459 SRS4218237 GSM3544145 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544145 GSM3544145 GEO Accession GSM3544145 SRX5214206 GSM3544146 SRP176459 SRS4218238 GSM3544146 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544146 GSM3544146 GEO Accession GSM3544146 SRX5214207 GSM3544147 SRP176459 SRS4218239 GSM3544147 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544147 GSM3544147 GEO Accession GSM3544147 SRX5214208 GSM3544148 SRP176459 SRS4218240 GSM3544148 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544148 GSM3544148 GEO Accession GSM3544148 SRX5214209 GSM3544149 SRP176459 SRS4218241 GSM3544149 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544149 GSM3544149 GEO Accession GSM3544149 SRX5214210 GSM3544150 SRP176459 SRS4218242 GSM3544150 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544150 GSM3544150 GEO Accession GSM3544150 SRX5214211 GSM3544151 SRP176459 SRS4218243 GSM3544151 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544151 GSM3544151 GEO Accession GSM3544151 SRX5214212 GSM3544152 SRP176459 SRS4218244 GSM3544152 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544152 GSM3544152 GEO Accession GSM3544152 SRX5214213 GSM3544153 SRP176459 SRS4218245 GSM3544153 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544153 GSM3544153 GEO Accession GSM3544153 SRX5214214 GSM3544154 SRP176459 SRS4218246 GSM3544154 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544154 GSM3544154 GEO Accession GSM3544154 SRX5214215 GSM3544155 SRP176459 SRS4218247 GSM3544155 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544155 GSM3544155 GEO Accession GSM3544155 SRX5214216 GSM3544156 SRP176459 SRS4218248 GSM3544156 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544156 GSM3544156 GEO Accession GSM3544156 SRX5214217 GSM3544157 SRP176459 SRS4218249 GSM3544157 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544157 GSM3544157 GEO Accession GSM3544157 SRX5214218 GSM3544270 SRP176459 SRS4218250 GSM3544270 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544270 GSM3544270 GEO Accession GSM3544270 SRX5214219 GSM3544271 SRP176459 SRS4218251 GSM3544271 RNA-Seq TRANSCRIPTOMIC cDNA For in vivo mouse samples, total RNA and DNA was extracted from the liver and the right hemisphere's hippocampus, cortex, and cerebellum with AllPrep® DNA/RNA/miRNA kit (Qiagen). Total RNA-seq libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina – San Diego, CA) according to manufacturer's instructions. 1µg of RNA was used as starting material and 12 PCR cycles were used to minimize bias. Library size was observed on an Agilent 2100 Bioanalyzer and quantity was determined using qPCR (KAPA Biosystems - Wilmington, MA). Libraries were sequences on an Illumina HiSeq 2500 using a 50-cycle rapid run kit or an Illumina NextSeq instrument using a 75-cycle high throughput kit. Reads were aligned to the GRCm38.p3 mouse genome and transcriptome from iGenomes using TopHat and differential expression tests were performed using featureCounts and edgeR with standard settings. Illumina HiSeq 2500 gds 303544271 GSM3544271 GEO Accession GSM3544271