<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE124817" accession="SRP176637">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP176637</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA513860</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE124817</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Glucocorticoids Promote Breast Cancer Metastasis</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>Next Generation Sequencing was applied to investigate the heterogeneity between tumors and distant metastases in different models of Breast Cancer cell lines and primary-derived xenografts. Global transcriptional profiling of the primary tumor and matched distant metastases (lung, liver, spleen) as well as circulating tumor cells (CTCs) allowed to identify glucocorticoid signalling as a mediator of metastasis. Overall design: RNA-Seq in 4 different Breast Cancer models to investigate glucorticoid signalling role in metastasis</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE124817</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_LINKS>
      <STUDY_LINK>
        <XREF_LINK>
          <DB>pubmed</DB>
          <ID>30867597</ID>
        </XREF_LINK>
      </STUDY_LINK>
    </STUDY_LINKS>
  </STUDY>
</STUDY_SET>
