<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE125106" accession="SRP179507">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP179507</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA515258</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE125106</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Genome-wide profiling of mutant p53 unveils a subset of lncRNAs correlated with colorectal cancer stemness maintenance [ChIP-seq]</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Other"/>
      <STUDY_ABSTRACT>RNA-sequencing and ChIP-sequencing were used to trace the lncRNAs regulated by p53-R273H in HCT116 endogenous p53 point mutant cell lines. Overall design: We set out to analyze the differentially expressed lncRNAs in p53-R273H colorectal cancer cell lines compared to wildtype control cell lines (wildtype cell lines as reference) by RNA-seq combined with ChIP-seq. RNA-seq profiling contained three replicates including p53-R273H mutant cell lines and wildtype control cell lines respectively. ChIP-seq profiling contained two replicates including input samples and ChIP samples both of p53-R273H mutant cell lines and wildtype control cell lines.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE125106</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_ATTRIBUTES>
      <STUDY_ATTRIBUTE>
        <TAG>parent_bioproject</TAG>
        <VALUE>PRJNA515257</VALUE>
      </STUDY_ATTRIBUTE>
    </STUDY_ATTRIBUTES>
  </STUDY>
</STUDY_SET>
