SRX5493729 GSM3660451 SRP187886 SRS4463587 GSM3660451 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660451 GSM3660451 GEO Accession GSM3660451 SRX5493730 GSM3660452 SRP187886 SRS4463588 GSM3660452 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660452 GSM3660452 GEO Accession GSM3660452 SRX5493731 GSM3660453 SRP187886 SRS4463589 GSM3660453 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660453 GSM3660453 GEO Accession GSM3660453 SRX5493732 GSM3660454 SRP187886 SRS4463590 GSM3660454 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660454 GSM3660454 GEO Accession GSM3660454 SRX5493733 GSM3660455 SRP187886 SRS4463591 GSM3660455 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660455 GSM3660455 GEO Accession GSM3660455 SRX5493734 GSM3660456 SRP187886 SRS4463592 GSM3660456 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660456 GSM3660456 GEO Accession GSM3660456 SRX5493735 GSM3660457 SRP187886 SRS4463593 GSM3660457 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660457 GSM3660457 GEO Accession GSM3660457 SRX5493736 GSM3660458 SRP187886 SRS4463594 GSM3660458 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660458 GSM3660458 GEO Accession GSM3660458 SRX5493737 GSM3660459 SRP187886 SRS4463595 GSM3660459 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660459 GSM3660459 GEO Accession GSM3660459 SRX5493738 GSM3660460 SRP187886 SRS4463596 GSM3660460 OTHER GENOMIC other The initial steps of 4C protocol were performed as published before (Splinter et al., 2012; Methods (PMID: 22929766)). Briefly, cells are cross-linked using 2% formaldehyde for 10min at room temperature in PBS 10%FCS and nuclei are isolated, after which chromatin is digested with DpnII and subsequently ligated. After reversal of the cross-links, the DNA is purified and treated with the second restriction enzyme Csp6I. After a second re-ligation step, the sample is purified and a 4C PCR directly on this template for mouse genome viewpoints. In order to PCR amplify the ectopic TetO viewpoint, 4C templates were treated with Cas9 in vitro. Cas9 is targeted into the TetO repeats by using a sgRNA designed in between 4C viewpoint primers. NextSeq 500 gds 303660460 GSM3660460 GEO Accession GSM3660460