SRP189088 PRJNA528481 RNA sequencing analysis of therapeutic mechanisms of atrial fibrillation treated with curcumin in rat model We first discovered that curcumin can treat atrial fibrillation in rat model and can reverse the effects of atrial fibrosis. In order to illustrate the potential therapeutic mechanism of curcumin against atrial fibrillation, Transcriptome sequencing and analysis were conducted to help deepen the comprehensive understanding of curcumin's therapeutic effects, to further understand the pathogenesis of atrial fibrillation, and to provide opportunities for new treatment, diagnosis and prevention strategies.