<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE131092" accession="SRP198245">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP198245</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA542643</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE131092</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>RNA-seq analysis of vehicle and DOPPA-treated human cord blood CD34+ cells</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>In this study, we did RNA-sequencing analysis to check the transcriptome of vehicle and DOPPA-treated CD34+ cells after 4 days ex-vivo culture. We noticed that expression of many genes which encode cell surface proteins including ITGA6 (CD49f) were significantly up-regulated, FDR-adjusted p-value &lt; 0.01 and the fold change (FC) &gt; 2, by DOPPA treatment. Gene ontology (GO) analysis revealed that many GO functions related to cell surface or plasma membrane related GOs which all include ITGA6 were significantly enriched in up-regulated differentially expressed genes (DEGs) including ITGA6 after DOPPA treatment. These data suggest that DOPPA treatment promotes transcription of ITGA6. Overall design: Identification of the differentially expressed mRNA profiles in vehicle and DOPPA expanded human cord blood CD34+ cells.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE131092</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
  </STUDY>
</STUDY_SET>
