SRX5828047 GSM3764992 SRP198353 SRS4755747 GSM3764992 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303764992 GSM3764992 SRX5828048 GSM3764993 SRP198353 SRS4755748 GSM3764993 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303764993 GSM3764993 SRX5828049 GSM3764994 SRP198353 SRS4755749 GSM3764994 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303764994 GSM3764994 SRX5828050 GSM3764995 SRP198353 SRS4755750 GSM3764995 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303764995 GSM3764995 SRX5828051 GSM3764996 SRP198353 SRS4755751 GSM3764996 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303764996 GSM3764996 SRX5828052 GSM3764997 SRP198353 SRS4755752 GSM3764997 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303764997 GSM3764997 SRX5828053 GSM3764998 SRP198353 SRS4755753 GSM3764998 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303764998 GSM3764998 SRX5828054 GSM3764999 SRP198353 SRS4755754 GSM3764999 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303764999 GSM3764999 SRX5828055 GSM3765000 SRP198353 SRS4755755 GSM3765000 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303765000 GSM3765000 SRX5828056 GSM3765001 SRP198353 SRS4755756 GSM3765001 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303765001 GSM3765001 SRX5828057 GSM3765002 SRP198353 SRS4755757 GSM3765002 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303765002 GSM3765002 SRX5828058 GSM3765003 SRP198353 SRS4755758 GSM3765003 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303765003 GSM3765003 SRX5828059 GSM3765004 SRP198353 SRS4755759 GSM3765004 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303765004 GSM3765004 SRX5828060 GSM3765005 SRP198353 SRS4755760 GSM3765005 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303765005 GSM3765005 SRX5828061 GSM3765006 SRP198353 SRS4755761 GSM3765006 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303765006 GSM3765006 SRX5828062 GSM3765007 SRP198353 SRS4755762 GSM3765007 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303765007 GSM3765007 SRX5828063 GSM3765008 SRP198353 SRS4755763 GSM3765008 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA were extracted using E.Z.N.A. Total RNA kit I (Omega, R6834), according to manufacture's protocol. RNA samples with RNA Integrity number above 8.0 were seleced for library preparation in Geogia Genomic and Bioinformatic Core (https://dna.uga.edu/). KAPA Stranded mRNA-Seq Kit for Illumina® Platforms (KR0960-v5.17) were used for library constructions of all RNA-Seq samples included in this study. Pair-end stranded libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 303765008 GSM3765008 SRX8213695 GSM4506443 SRP198353 PRJNA542809 SRS6572923 GSM4506443 ATAC-seq GENOMIC other The ATAC-Seq samples were prepared following the Omni-ATAC Seq protocol (Corces et al., 2017). In brief, single cell suspension of PM cells and BA cells were generated using Accumax and collagenase Mix as described in the cell culture and differentiation session of method. 50,000 cells were pelleted at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in sterile water-based resuspension buffer containing 10 mM Tris-HCl pH=7.4 (Thermo Fisher, 15567-027), 10 mM NaCl (Thermo Fisher, AM9760G), 3 mM MgCl2 (Thermo Fisher, AM9530G), 0.1% NP-40 (Abcam, ab142247), 0.1% Tween-20 and 0.01% Digitonin (Thermo Fisher, BN2006) and incubated on ice for 3 minutes. Subsequent to incubation, lysis was washed by a water-based washing buffer containing 10 mM Tris-HCl pH=7.4, 10 mM NaCl, 3 mM MgCl2 and 0.1% Tween-20. The lysis was then subject to centrifuge at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in 50 μl of transposition mixture consisting of 25 μl 2X TD Buffer (illumina, 15027866), 2.5 μl Tn5 transposase (illumina, 15027865), 16.5 μl PBS, 0.5 μl 1% Digitonin, 0.5 μl 10% Tween-20, 5 μl H2O and incubated at 37 °C for 30 minutes. The reaction mix was later cleaned up using Zymo DNA Clean and Concentrator-5 kit (Zymo Research, D4014). Library was then constructed by PCR amplification as instructed in the Omin-ATAC protocol and purified by Omega Mag-Bind RXNPure plus beads (Omega, M1386-01). Single-end libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 304506443 GSM4506443 GEO Accession GSM4506443 SRX8213696 GSM4506444 SRP198353 PRJNA542809 SRS6572924 GSM4506444 ATAC-seq GENOMIC other The ATAC-Seq samples were prepared following the Omni-ATAC Seq protocol (Corces et al., 2017). In brief, single cell suspension of PM cells and BA cells were generated using Accumax and collagenase Mix as described in the cell culture and differentiation session of method. 50,000 cells were pelleted at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in sterile water-based resuspension buffer containing 10 mM Tris-HCl pH=7.4 (Thermo Fisher, 15567-027), 10 mM NaCl (Thermo Fisher, AM9760G), 3 mM MgCl2 (Thermo Fisher, AM9530G), 0.1% NP-40 (Abcam, ab142247), 0.1% Tween-20 and 0.01% Digitonin (Thermo Fisher, BN2006) and incubated on ice for 3 minutes. Subsequent to incubation, lysis was washed by a water-based washing buffer containing 10 mM Tris-HCl pH=7.4, 10 mM NaCl, 3 mM MgCl2 and 0.1% Tween-20. The lysis was then subject to centrifuge at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in 50 μl of transposition mixture consisting of 25 μl 2X TD Buffer (illumina, 15027866), 2.5 μl Tn5 transposase (illumina, 15027865), 16.5 μl PBS, 0.5 μl 1% Digitonin, 0.5 μl 10% Tween-20, 5 μl H2O and incubated at 37 °C for 30 minutes. The reaction mix was later cleaned up using Zymo DNA Clean and Concentrator-5 kit (Zymo Research, D4014). Library was then constructed by PCR amplification as instructed in the Omin-ATAC protocol and purified by Omega Mag-Bind RXNPure plus beads (Omega, M1386-01). Single-end libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 304506444 GSM4506444 GEO Accession GSM4506444 SRX8213697 GSM4506445 SRP198353 PRJNA542809 SRS6572925 GSM4506445 ATAC-seq GENOMIC other The ATAC-Seq samples were prepared following the Omni-ATAC Seq protocol (Corces et al., 2017). In brief, single cell suspension of PM cells and BA cells were generated using Accumax and collagenase Mix as described in the cell culture and differentiation session of method. 50,000 cells were pelleted at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in sterile water-based resuspension buffer containing 10 mM Tris-HCl pH=7.4 (Thermo Fisher, 15567-027), 10 mM NaCl (Thermo Fisher, AM9760G), 3 mM MgCl2 (Thermo Fisher, AM9530G), 0.1% NP-40 (Abcam, ab142247), 0.1% Tween-20 and 0.01% Digitonin (Thermo Fisher, BN2006) and incubated on ice for 3 minutes. Subsequent to incubation, lysis was washed by a water-based washing buffer containing 10 mM Tris-HCl pH=7.4, 10 mM NaCl, 3 mM MgCl2 and 0.1% Tween-20. The lysis was then subject to centrifuge at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in 50 μl of transposition mixture consisting of 25 μl 2X TD Buffer (illumina, 15027866), 2.5 μl Tn5 transposase (illumina, 15027865), 16.5 μl PBS, 0.5 μl 1% Digitonin, 0.5 μl 10% Tween-20, 5 μl H2O and incubated at 37 °C for 30 minutes. The reaction mix was later cleaned up using Zymo DNA Clean and Concentrator-5 kit (Zymo Research, D4014). Library was then constructed by PCR amplification as instructed in the Omin-ATAC protocol and purified by Omega Mag-Bind RXNPure plus beads (Omega, M1386-01). Single-end libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 304506445 GSM4506445 GEO Accession GSM4506445 SRX8213698 GSM4506446 SRP198353 PRJNA542809 SRS6572926 GSM4506446 ATAC-seq GENOMIC other The ATAC-Seq samples were prepared following the Omni-ATAC Seq protocol (Corces et al., 2017). In brief, single cell suspension of PM cells and BA cells were generated using Accumax and collagenase Mix as described in the cell culture and differentiation session of method. 50,000 cells were pelleted at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in sterile water-based resuspension buffer containing 10 mM Tris-HCl pH=7.4 (Thermo Fisher, 15567-027), 10 mM NaCl (Thermo Fisher, AM9760G), 3 mM MgCl2 (Thermo Fisher, AM9530G), 0.1% NP-40 (Abcam, ab142247), 0.1% Tween-20 and 0.01% Digitonin (Thermo Fisher, BN2006) and incubated on ice for 3 minutes. Subsequent to incubation, lysis was washed by a water-based washing buffer containing 10 mM Tris-HCl pH=7.4, 10 mM NaCl, 3 mM MgCl2 and 0.1% Tween-20. The lysis was then subject to centrifuge at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in 50 μl of transposition mixture consisting of 25 μl 2X TD Buffer (illumina, 15027866), 2.5 μl Tn5 transposase (illumina, 15027865), 16.5 μl PBS, 0.5 μl 1% Digitonin, 0.5 μl 10% Tween-20, 5 μl H2O and incubated at 37 °C for 30 minutes. The reaction mix was later cleaned up using Zymo DNA Clean and Concentrator-5 kit (Zymo Research, D4014). Library was then constructed by PCR amplification as instructed in the Omin-ATAC protocol and purified by Omega Mag-Bind RXNPure plus beads (Omega, M1386-01). Single-end libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 304506446 GSM4506446 GEO Accession GSM4506446 SRX8213699 GSM4506447 SRP198353 PRJNA542809 SRS6572927 GSM4506447 ATAC-seq GENOMIC other The ATAC-Seq samples were prepared following the Omni-ATAC Seq protocol (Corces et al., 2017). In brief, single cell suspension of PM cells and BA cells were generated using Accumax and collagenase Mix as described in the cell culture and differentiation session of method. 50,000 cells were pelleted at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in sterile water-based resuspension buffer containing 10 mM Tris-HCl pH=7.4 (Thermo Fisher, 15567-027), 10 mM NaCl (Thermo Fisher, AM9760G), 3 mM MgCl2 (Thermo Fisher, AM9530G), 0.1% NP-40 (Abcam, ab142247), 0.1% Tween-20 and 0.01% Digitonin (Thermo Fisher, BN2006) and incubated on ice for 3 minutes. Subsequent to incubation, lysis was washed by a water-based washing buffer containing 10 mM Tris-HCl pH=7.4, 10 mM NaCl, 3 mM MgCl2 and 0.1% Tween-20. The lysis was then subject to centrifuge at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in 50 μl of transposition mixture consisting of 25 μl 2X TD Buffer (illumina, 15027866), 2.5 μl Tn5 transposase (illumina, 15027865), 16.5 μl PBS, 0.5 μl 1% Digitonin, 0.5 μl 10% Tween-20, 5 μl H2O and incubated at 37 °C for 30 minutes. The reaction mix was later cleaned up using Zymo DNA Clean and Concentrator-5 kit (Zymo Research, D4014). Library was then constructed by PCR amplification as instructed in the Omin-ATAC protocol and purified by Omega Mag-Bind RXNPure plus beads (Omega, M1386-01). Single-end libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 304506447 GSM4506447 GEO Accession GSM4506447 SRX8213700 GSM4506448 SRP198353 PRJNA542809 SRS6572928 GSM4506448 ATAC-seq GENOMIC other The ATAC-Seq samples were prepared following the Omni-ATAC Seq protocol (Corces et al., 2017). In brief, single cell suspension of PM cells and BA cells were generated using Accumax and collagenase Mix as described in the cell culture and differentiation session of method. 50,000 cells were pelleted at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in sterile water-based resuspension buffer containing 10 mM Tris-HCl pH=7.4 (Thermo Fisher, 15567-027), 10 mM NaCl (Thermo Fisher, AM9760G), 3 mM MgCl2 (Thermo Fisher, AM9530G), 0.1% NP-40 (Abcam, ab142247), 0.1% Tween-20 and 0.01% Digitonin (Thermo Fisher, BN2006) and incubated on ice for 3 minutes. Subsequent to incubation, lysis was washed by a water-based washing buffer containing 10 mM Tris-HCl pH=7.4, 10 mM NaCl, 3 mM MgCl2 and 0.1% Tween-20. The lysis was then subject to centrifuge at 500 RCF at 4 °C for 5 mins. After removal of supernatant, pellet was resuspended in 50 μl of transposition mixture consisting of 25 μl 2X TD Buffer (illumina, 15027866), 2.5 μl Tn5 transposase (illumina, 15027865), 16.5 μl PBS, 0.5 μl 1% Digitonin, 0.5 μl 10% Tween-20, 5 μl H2O and incubated at 37 °C for 30 minutes. The reaction mix was later cleaned up using Zymo DNA Clean and Concentrator-5 kit (Zymo Research, D4014). Library was then constructed by PCR amplification as instructed in the Omin-ATAC protocol and purified by Omega Mag-Bind RXNPure plus beads (Omega, M1386-01). Single-end libraries were construced and then sequenced in NextSeq platform with read length 75 bp. Each sample has more than 30 millions read per end. NextSeq 500 gds 304506448 GSM4506448 GEO Accession GSM4506448