SRP198481 PRJNA543056 GSE131249 RNA-seq of human aneuploid cell lines with Trisomy 21 Trisomy 21, a form of aneuploidy, is one of the few viable forms of trisomy. The goal of this study was to assess the effect of an additional chromosome 21 on gene expression in two different human aneuploid model cell lines. Overall design: HiSeq Illumina sequencing of total RNA for two whole-chromosome aneuploid cell lines with an extra copy of chromosome 21 and their corresponding parental cell line. GSE131249 pubmed 31799603