SRP208081 JCVI ESCHERICHIA COLI E22 Sequencing ESCHERICHIA COLI E22 SRP295945 PRJNA15577 Enteropathogenic Escherichia coli <i><B>Escherichia coli</i> strain E22</B>. This is an enteropathogenic (EPEC) strain of <i>Escherichia coli</i> and has been used in the development of a model system of infection in rabbits. It was provided by Drs. James B. Kaper and Edward Boedeker from the School of Medicine, University of Maryland. This strain produces a number of virulence factors including serotype O103:H2 and the locus of enterocyte effacement (LEE) type III secretion system pathogenicity island that is responsible for producing secreted effector proteins that cause the typical attachment/effacing (A/E) lesions of the epithelial layer. Genomic sequencing included a small insert library (4-5 kb) and a large insert library (10-12 kb) from which 22,181 and 48,178 reads were sequenced, respectively. This amount of sequence represents 11X coverage of the genome. The preliminary project assembly is composed of 109 contigs. Escherichia coli E22 GOLD http://genomesonline.org/cgi-bin/GOLD/bin/GOLDCards.cgi?goldstamp=Gi01135