SRX6384029 GSM3911164 SRP212619 SRS5043547 GSM3911164 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911164 GSM3911164 GEO Accession GSM3911164 SRX6384030 GSM3911165 SRP212619 SRS5043548 GSM3911165 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911165 GSM3911165 GEO Accession GSM3911165 SRX6384031 GSM3911166 SRP212619 SRS5043549 GSM3911166 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911166 GSM3911166 GEO Accession GSM3911166 SRX6384032 GSM3911167 SRP212619 SRS5043550 GSM3911167 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911167 GSM3911167 GEO Accession GSM3911167 SRX6384033 GSM3911168 SRP212619 SRS5043551 GSM3911168 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911168 GSM3911168 GEO Accession GSM3911168 SRX6384034 GSM3911169 SRP212619 SRS5043553 GSM3911169 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911169 GSM3911169 GEO Accession GSM3911169 SRX6384035 GSM3911170 SRP212619 SRS5043552 GSM3911170 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911170 GSM3911170 GEO Accession GSM3911170 SRX6384036 GSM3911171 SRP212619 SRS5043554 GSM3911171 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911171 GSM3911171 GEO Accession GSM3911171 SRX6384037 GSM3911172 SRP212619 SRS5043555 GSM3911172 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911172 GSM3911172 GEO Accession GSM3911172 SRX6384038 GSM3911173 SRP212619 SRS5043556 GSM3911173 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911173 GSM3911173 GEO Accession GSM3911173 SRX6384039 GSM3911174 SRP212619 SRS5043557 GSM3911174 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911174 GSM3911174 GEO Accession GSM3911174 SRX6384040 GSM3911175 SRP212619 SRS5043558 GSM3911175 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911175 GSM3911175 GEO Accession GSM3911175 SRX6384041 GSM3911176 SRP212619 SRS5043559 GSM3911176 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911176 GSM3911176 GEO Accession GSM3911176 SRX6384042 GSM3911177 SRP212619 SRS5043560 GSM3911177 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911177 GSM3911177 GEO Accession GSM3911177 SRX6384043 GSM3911178 SRP212619 SRS5043561 GSM3911178 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911178 GSM3911178 GEO Accession GSM3911178 SRX6384044 GSM3911179 SRP212619 SRS5043562 GSM3911179 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911179 GSM3911179 GEO Accession GSM3911179 SRX6384045 GSM3911180 SRP212619 SRS5043563 GSM3911180 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911180 GSM3911180 GEO Accession GSM3911180 SRX6384046 GSM3911181 SRP212619 SRS5043564 GSM3911181 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911181 GSM3911181 GEO Accession GSM3911181 SRX6384047 GSM3911182 SRP212619 SRS5043565 GSM3911182 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911182 GSM3911182 GEO Accession GSM3911182 SRX6384048 GSM3911183 SRP212619 SRS5043566 GSM3911183 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911183 GSM3911183 GEO Accession GSM3911183 SRX6384049 GSM3911184 SRP212619 SRS5043567 GSM3911184 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911184 GSM3911184 GEO Accession GSM3911184 SRX6384050 GSM3911185 SRP212619 SRS5043568 GSM3911185 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911185 GSM3911185 GEO Accession GSM3911185 SRX6384051 GSM3911186 SRP212619 SRS5043569 GSM3911186 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911186 GSM3911186 GEO Accession GSM3911186 SRX6384052 GSM3911187 SRP212619 SRS5043570 GSM3911187 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911187 GSM3911187 GEO Accession GSM3911187 SRX6384053 GSM3911188 SRP212619 SRS5043571 GSM3911188 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911188 GSM3911188 GEO Accession GSM3911188 SRX6384054 GSM3911189 SRP212619 SRS5043573 GSM3911189 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911189 GSM3911189 GEO Accession GSM3911189 SRX6384055 GSM3911190 SRP212619 SRS5043572 GSM3911190 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 2500 gds 303911190 GSM3911190 GEO Accession GSM3911190 SRX6384056 GSM3911191 SRP212619 SRS5043574 GSM3911191 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911191 GSM3911191 GEO Accession GSM3911191 SRX6384057 GSM3911192 SRP212619 SRS5043575 GSM3911192 RNA-Seq TRANSCRIPTOMIC cDNA RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911192 GSM3911192 GEO Accession GSM3911192 SRX6384058 GSM3911193 SRP212619 SRS5043576 GSM3911193 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911193 GSM3911193 GEO Accession GSM3911193 SRX6384059 GSM3911194 SRP212619 SRS5043577 GSM3911194 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911194 GSM3911194 GEO Accession GSM3911194 SRX6384060 GSM3911195 SRP212619 SRS5043578 GSM3911195 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911195 GSM3911195 GEO Accession GSM3911195 SRX6384061 GSM3911196 SRP212619 SRS5043579 GSM3911196 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911196 GSM3911196 GEO Accession GSM3911196 SRX6384062 GSM3911197 SRP212619 SRS5043580 GSM3911197 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911197 GSM3911197 GEO Accession GSM3911197 SRX6384063 GSM3911198 SRP212619 SRS5043581 GSM3911198 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911198 GSM3911198 GEO Accession GSM3911198 SRX6384064 GSM3911199 SRP212619 SRS5043582 GSM3911199 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911199 GSM3911199 GEO Accession GSM3911199 SRX6384065 GSM3911200 SRP212619 SRS5043583 GSM3911200 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911200 GSM3911200 GEO Accession GSM3911200 SRX6384066 GSM3911201 SRP212619 SRS5043584 GSM3911201 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911201 GSM3911201 GEO Accession GSM3911201 SRX6384067 GSM3911202 SRP212619 SRS5043585 GSM3911202 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911202 GSM3911202 GEO Accession GSM3911202 SRX6384068 GSM3911203 SRP212619 SRS5043586 GSM3911203 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911203 GSM3911203 GEO Accession GSM3911203 SRX6384069 GSM3911204 SRP212619 SRS5043587 GSM3911204 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911204 GSM3911204 GEO Accession GSM3911204 SRX6384070 GSM3911205 SRP212619 SRS5043588 GSM3911205 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911205 GSM3911205 GEO Accession GSM3911205 SRX6384071 GSM3911206 SRP212619 SRS5043589 GSM3911206 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911206 GSM3911206 GEO Accession GSM3911206 SRX6384072 GSM3911207 SRP212619 SRS5043590 GSM3911207 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911207 GSM3911207 GEO Accession GSM3911207 SRX6384073 GSM3911208 SRP212619 SRS5043591 GSM3911208 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911208 GSM3911208 GEO Accession GSM3911208 SRX6384074 GSM3911209 SRP212619 SRS5043592 GSM3911209 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911209 GSM3911209 GEO Accession GSM3911209 SRX6384075 GSM3911210 SRP212619 SRS5043593 GSM3911210 ChIP-Seq GENOMIC ChIP RNA-Seq: Cells were sorted using Aria-II and RNA was extracted with Trizol according to manufacturer's instructions, followed by treatment with rDNase from Nucleospin RNA XS extraction kit (Macherey-Nagel) ChIP-Seq: Cells were enriched using MACS CD19 microbeads and LS columns, fixed with 1% pfa at RT for 10 min. Chromatin was precipitated using 5 μg of anti-AP4, 1 μg of anti-H3K27ac (ab4729, Abcam), and 5 μg of anti-rabbit IgG (Thermofisher) and Dynabeads protein-G magnetic beads (Life Technologies). After reverse crosslinking, precipitated DNA was purified using a GenElute PCR Clean Up Kit (Sigma) and quantitated using a Qubit DNA quantitation kit (Life Technologies). RNA-Seq: Library preparation was performed with 0.1-1ug of total RNA, integrity was determined using an Agilent bioanalyzer or tapestation. Ribosomal RNA was removed by a hybridization method using Ribo-ZERO kits (Illumina). mRNA was then fragmented in buffer containing 40mM Tris Acetate pH 8.2, 100mM Potassium Acetate and 30mM Magnesium Acetate and heating to 94 degrees for 150 seconds. mRNA was reverse transcribed to yield cDNA using SuperScript III RT enzyme (Life Technologies, per manufacturer's instructions) and random hexamers. A second strand reaction was performed to yield ds-cDNA. cDNA was blunt ended, had an A base added to the 3' ends, and then had Illumina sequencing adapters ligated to the ends. Ligated fragments were then amplified for 15 cycles using primers incorporating the p5 and p7 sequences and unique index tags. Fragments were sequenced on an Illumina HiSeq2500 or HiSeq3000 using single reads extending 50 bases. ChIP_Seq Library preparation was performed with 10ng of chIP DNA, size range was assayed on Agilent Bioanalyzer High Sensitivity DNA chips. ChIP DNA was blunt ended, had addition of “A” base to 3' end, and had sequencing adapters ligated to the ends. The fragments were size selected to 200-600 base pairs, and underwent amplification for 15 cycles with primers incorporating p5 and p7 sequences and a unique index tag for multiplexing. The resulting libraries were sequenced using the Illumina HiSeq3000 as single reads extending 50 bases. Illumina HiSeq 3000 gds 303911210 GSM3911210 GEO Accession GSM3911210