SRX6384076 GSM3911214 SRP212620 SRS5043594 GSM3911214 ChIP-Seq GENOMIC ChIP ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911214 GSM3911214 GEO Accession GSM3911214 SRX6384077 GSM3911215 SRP212620 SRS5043595 GSM3911215 ChIP-Seq GENOMIC ChIP ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911215 GSM3911215 GEO Accession GSM3911215 SRX6384078 GSM3911216 SRP212620 SRS5043596 GSM3911216 ChIP-Seq GENOMIC ChIP ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911216 GSM3911216 GEO Accession GSM3911216 SRX6384079 GSM3911217 SRP212620 SRS5043597 GSM3911217 ChIP-Seq GENOMIC ChIP ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911217 GSM3911217 GEO Accession GSM3911217 SRX6384080 GSM3911218 SRP212620 SRS5043598 GSM3911218 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911218 GSM3911218 GEO Accession GSM3911218 SRX6384081 GSM3911219 SRP212620 SRS5043599 GSM3911219 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911219 GSM3911219 GEO Accession GSM3911219 SRX6384082 GSM3911220 SRP212620 SRS5043600 GSM3911220 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911220 GSM3911220 GEO Accession GSM3911220 SRX6384083 GSM3911221 SRP212620 SRS5043602 GSM3911221 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911221 GSM3911221 GEO Accession GSM3911221 SRX6384084 GSM3911222 SRP212620 SRS5043601 GSM3911222 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911222 GSM3911222 GEO Accession GSM3911222 SRX6384085 GSM3911223 SRP212620 SRS5043603 GSM3911223 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911223 GSM3911223 GEO Accession GSM3911223 SRX6384086 GSM3911224 SRP212620 SRS5043604 GSM3911224 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911224 GSM3911224 GEO Accession GSM3911224 SRX6384087 GSM3911225 SRP212620 SRS5043605 GSM3911225 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911225 GSM3911225 GEO Accession GSM3911225 SRX6384088 GSM3911226 SRP212620 SRS5043606 GSM3911226 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911226 GSM3911226 GEO Accession GSM3911226 SRX6384089 GSM3911227 SRP212620 SRS5043607 GSM3911227 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911227 GSM3911227 GEO Accession GSM3911227 SRX6384090 GSM3911228 SRP212620 SRS5043608 GSM3911228 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911228 GSM3911228 GEO Accession GSM3911228 SRX6384091 GSM3911229 SRP212620 SRS5043609 GSM3911229 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911229 GSM3911229 GEO Accession GSM3911229 SRX6384092 GSM3911230 SRP212620 SRS5043610 GSM3911230 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911230 GSM3911230 GEO Accession GSM3911230 SRX6384093 GSM3911231 SRP212620 SRS5043611 GSM3911231 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911231 GSM3911231 GEO Accession GSM3911231 SRX6384094 GSM3911232 SRP212620 SRS5043612 GSM3911232 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911232 GSM3911232 GEO Accession GSM3911232 SRX6384095 GSM3911233 SRP212620 SRS5043613 GSM3911233 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911233 GSM3911233 GEO Accession GSM3911233 SRX6384096 GSM3911234 SRP212620 SRS5043614 GSM3911234 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911234 GSM3911234 GEO Accession GSM3911234 SRX6384097 GSM3911235 SRP212620 SRS5043615 GSM3911235 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911235 GSM3911235 GEO Accession GSM3911235 SRX6384098 GSM3911236 SRP212620 SRS5043616 GSM3911236 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911236 GSM3911236 GEO Accession GSM3911236 SRX6384099 GSM3911237 SRP212620 SRS5043617 GSM3911237 RNA-Seq TRANSCRIPTOMIC cDNA ChIP samples were washed with RIPA wash buffer (50mM Hepes, 500mM LiCl, 1mM EDTA, 1% NP-40, 0.7% Na-Deoxycholate) 3 times followed by wash with Annealing buffer (TE+ 50mM NaCl). Elution Buffer (1% SDS, 50mM Tris-HCl, 10mM EDTA) was added to each ChIP samples and heated at 65°C for 30min. Beads were subsequently removed and samples were heated, at 14000rpm, 65°C and supplemented with 0.2 mg/mL RNase A (ThermoFisher). 0.2 mg/mL Proteinase K (Life Technologies) were added the next day to digest proteins by incubating shaking at 450rpm at 65°C for 4h. ChIP purified by PCR purification Kit (Qiagen). PBS and LB1, LB2, LB3 and RIPA wash buffers were all supplemented with Sodium Butyrate (Sigma), cOmplete EDTA-free protease inhibitor cocktail (Roche) and PMSF (Sigma) immediately before use. RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 303911237 GSM3911237 GEO Accession GSM3911237 SRX8453065 GSM4586645 SRP212620 PRJNA551672 SRS6754692 GSM4586645 RNA-Seq TRANSCRIPTOMIC cDNA RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 304586645 GSM4586645 GEO Accession GSM4586645 SRX8453066 GSM4586646 SRP212620 PRJNA551672 SRS6754693 GSM4586646 RNA-Seq TRANSCRIPTOMIC cDNA RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 304586646 GSM4586646 GEO Accession GSM4586646 SRX8453067 GSM4586647 SRP212620 PRJNA551672 SRS6754694 GSM4586647 RNA-Seq TRANSCRIPTOMIC cDNA RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 304586647 GSM4586647 GEO Accession GSM4586647 SRX8453068 GSM4586648 SRP212620 PRJNA551672 SRS6754695 GSM4586648 RNA-Seq TRANSCRIPTOMIC cDNA RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 304586648 GSM4586648 GEO Accession GSM4586648 SRX8453069 GSM4586649 SRP212620 PRJNA551672 SRS6754696 GSM4586649 RNA-Seq TRANSCRIPTOMIC cDNA RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 304586649 GSM4586649 GEO Accession GSM4586649 SRX8453070 GSM4586650 SRP212620 PRJNA551672 SRS6754697 GSM4586650 RNA-Seq TRANSCRIPTOMIC cDNA RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 304586650 GSM4586650 GEO Accession GSM4586650 SRX8453071 GSM4586651 SRP212620 PRJNA551672 SRS6754698 GSM4586651 RNA-Seq TRANSCRIPTOMIC cDNA RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 304586651 GSM4586651 GEO Accession GSM4586651 SRX8453072 GSM4586652 SRP212620 PRJNA551672 SRS6754699 GSM4586652 RNA-Seq TRANSCRIPTOMIC cDNA RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 304586652 GSM4586652 GEO Accession GSM4586652 SRX8453073 GSM4586653 SRP212620 PRJNA551672 SRS6754700 GSM4586653 RNA-Seq TRANSCRIPTOMIC cDNA RNA was extracted from AML cells with RNeasy Plus Mini Kit (Qiagen) according to manufacturer's instructions. Sequencing was performed on Illumina HiSeq v4 platform with 75-bp paired-end sequencing. Illumina HiSeq 2500 gds 304586653 GSM4586653 GEO Accession GSM4586653