SRP212624 PRJNA551678 GSE133521 RNA-seq analysis of A498 cell line treated with siSETD2 or si-NC the coordinated expression of SETD2-miRNAs-MAPK/JNK may be predictive of poor prognostic in patients with RCC. Our findings also emphasize the therapeutic potential of MAP4K4 in RCC therapy and support the development of an effective therapeutic strategy to target MAP4K4 by molecularly targeted approaches. Overall design: six samples. Including three siSETD2 samples and three control samples GSE133521