<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE133922" accession="SRP213598">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP213598</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA553133</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE133922</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>RNA-sequencing of a longitudinal comparison of four principal mesenchymal and endothelial stromal cell types (CXCL12-abundant reticular cells, PDGFR-a+ Sca-1+, sinusoidal and arterial endothelial cells), isolated from early postnatal, adult and aged mice. Additional transcriptional profiling of the response of CXCL12-abundant reticular cells and sinusoidal endothelial cells to infection-mimicking agents. Overall design: RNA-sequencing of four FACS-isolated mouse bone marrow stromal cells at different age stages and conditions.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE133922</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_LINKS>
      <STUDY_LINK>
        <XREF_LINK>
          <DB>pubmed</DB>
          <ID>31801092</ID>
        </XREF_LINK>
      </STUDY_LINK>
    </STUDY_LINKS>
  </STUDY>
</STUDY_SET>
