SRP213718 PRJNA553231 GSE133978 RNA-seq of cold stimulated inguinal fat of wild type and Rarres2-/- mice Although various stimuli and mediators have been identified to promote thermogenic beige fat development, less is known about the negative regulator of cold-induced beiging. We here show that lack of chemerin that is highly expressed in white adipose tissue or its receptor CMKLR1 in adipocytes enhances cold-induced beiging and thermogenesis. Our results reveal a previously unrecognized beige-inhibitory role of chemerin-CMKLR1 axis, and suggests CMKLR1 as a therapeutic target for obesity-related metabolic disorders. Overall design: Total RNA profiles of 8-week old wild type (WT) and Rarres2-/- mice were generated by deep sequencing using Illumina Hiseq 2000. GSE133978