<?xml version="1.0" encoding="UTF-8"?>
<EXPERIMENT_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <EXPERIMENT alias="GSM3956905" accession="SRX6478166">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478166</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956905</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956905: HiC-K562-MockNuclei-5min-R2; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128450">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128450</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956905</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.0</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956905</ID>
          <LABEL>GSM3956905</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956905</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956906" accession="SRX6478167">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478167</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956906</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956906: HiC-K562-HindIII-predigest-4h-R2; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128451">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128451</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956906</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.1</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956906</ID>
          <LABEL>GSM3956906</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956906</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956907" accession="SRX6478168">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478168</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956907</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956907: HiC-K562-DpnII-predigest-16h-R2; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128452">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128452</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956907</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.2</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956907</ID>
          <LABEL>GSM3956907</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956907</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956908" accession="SRX6478169">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478169</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956908</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956908: HiC-K562-DpnII-predigest-4h-R2; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128453">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128453</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956908</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.3</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956908</ID>
          <LABEL>GSM3956908</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956908</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956909" accession="SRX6478170">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478170</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956909</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956909: HiC-K562-DpnII-predigest-3h-R2; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128454">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128454</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956909</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.4</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956909</ID>
          <LABEL>GSM3956909</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956909</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956910" accession="SRX6478171">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478171</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956910</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956910: HiC-K562-DpnII-predigest-2h-R2; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128455">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128455</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956910</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.5</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956910</ID>
          <LABEL>GSM3956910</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956910</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956911" accession="SRX6478172">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478172</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956911</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956911: HiC-K562-DpnII-predigest-1h-R2; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128456">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128456</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956911</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.6</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956911</ID>
          <LABEL>GSM3956911</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956911</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956912" accession="SRX6478173">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478173</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956912</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956912: HiC-K562-DpnII-predigest-5min-R2; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128457">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128457</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956912</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.7</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956912</ID>
          <LABEL>GSM3956912</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956912</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956913" accession="SRX6478174">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478174</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956913</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956913: HiC-K562-MockNuclei-4h-R2; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128458">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128458</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956913</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.8</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956913</ID>
          <LABEL>GSM3956913</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956913</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956914" accession="SRX6478175">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478175</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956914</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956914: HiC-K562-DpnII-predigest-16h-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128459">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128459</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956914</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.9</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956914</ID>
          <LABEL>GSM3956914</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956914</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956915" accession="SRX6478176">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478176</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956915</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956915: HiC-K562-DpnII-predigest-4h-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128460">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128460</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956915</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.10</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956915</ID>
          <LABEL>GSM3956915</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956915</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956916" accession="SRX6478177">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478177</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956916</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956916: HiC-K562-DpnII-predigest-3h-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128461">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128461</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956916</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.11</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956916</ID>
          <LABEL>GSM3956916</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956916</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956917" accession="SRX6478178">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478178</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956917</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956917: HiC-K562-DpnII-predigest-2h-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128462">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128462</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956917</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.12</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956917</ID>
          <LABEL>GSM3956917</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956917</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956918" accession="SRX6478179">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478179</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956918</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956918: HiC-K562-DpnII-predigest-1h-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128463">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128463</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956918</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.13</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956918</ID>
          <LABEL>GSM3956918</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956918</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956919" accession="SRX6478180">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478180</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956919</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956919: HiC-K562-DpnII-predigest-5min-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128464">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128464</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956919</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.14</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956919</ID>
          <LABEL>GSM3956919</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956919</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956920" accession="SRX6478181">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478181</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956920</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956920: HiC-K562-MockNuclei-4h-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128465">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128465</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956920</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.15</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956920</ID>
          <LABEL>GSM3956920</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956920</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956921" accession="SRX6478182">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478182</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956921</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956921: HiC-K562-HindIII-predigest-4h-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128466">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128466</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956921</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.16</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956921</ID>
          <LABEL>GSM3956921</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956921</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956922" accession="SRX6478183">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478183</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956922</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956922: HiC-K562-Nuclei-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128467">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128467</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956922</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) with some modifications in the crosslinking and lysis steps as described below. Crosslinking: isolated, undigested, and  pre-digested (with liquified chromatin) nuclei were not pelleted after the pre-digestion step above but were crosslinked immediately as follows: for each sample 1,250 µL volume of nuclei in the digestion buffer was transferred to a 21.875 mL mix [625 μL of 37% formaldehyde + 21.25 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked nuclei, the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Cells lysis: This step is not needed for isolated, undigested, and pre-digested (with liquified chromatin) nuclei Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.17</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956922</ID>
          <LABEL>GSM3956922</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956922</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956923" accession="SRX6478184">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478184</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956923</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956923: HiC-K562-Cell-R1; Homo sapiens; Hi-C</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128468">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128468</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956923</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>Hi-C</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Hi-C was performed as described (Hi-C 2.0 Belaghzal et al., 2017) . For intact cells: 5 million K562 cells or nuclei were washed twice with 15 mL of HBSS and pelleted at 300 g for 10 min, then resuspended in 2.5 mL of HBSS. The sample was transferred to 20.625 mL crosslinking mix [625 μL of 37% formaldehyde + 20 mL of HBSS]. Samples were incubated at RT for 10 min on a rocking platform. Next, to stop cross-linking 1.25 mL of 2.5 M glycine was added to each sample and the mix was incubated at RT for 5 min on a rocking platform. To pellet the crosslinked cells the sample was centrifuged at 1,000 g for 10 min at 4°C. The supernatant was discarded and the pellet was washed twice with HBSS before going to the next step or storing samples at -80°C. Lysis For Hi-C with intact cells: the 5 million cross-linked cells were lysed by adding 1 mL cold lysis buffer [10 mM Tris-HCl (pH=8.0), 10 mM NaCl, 0.2% Igepal CA-630 (NP40)] and 10 µL of 100X Protease inhibitors. The sample was incubated on ice for 15 min to let the cells swell. The cells were lysed on ice using a dounce homogenizer with pestle A by moving the pest Hi-C 2.0: We prepare the library for sequencing as described in Hi-C 2.17</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956923</ID>
          <LABEL>GSM3956923</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956923</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956924" accession="SRX6478185">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478185</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956924</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956924: DpnII-Seq-K562-90min-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128469">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128469</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956924</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956924</ID>
          <LABEL>GSM3956924</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956924</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956925" accession="SRX6478186">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478186</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956925</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956925: DpnII-Seq-K562-75min-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128470">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128470</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956925</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956925</ID>
          <LABEL>GSM3956925</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956925</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956926" accession="SRX6478187">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478187</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956926</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956926: DpnII-Seq-K562-45min-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128471">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128471</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956926</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956926</ID>
          <LABEL>GSM3956926</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956926</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956927" accession="SRX6478188">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478188</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956927</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956927: DpnII-Seq-K562-30min-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128472">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128472</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956927</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956927</ID>
          <LABEL>GSM3956927</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956927</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956928" accession="SRX6478189">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478189</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956928</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956928: DpnII-Seq-K562-15min-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128473">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128473</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956928</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956928</ID>
          <LABEL>GSM3956928</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956928</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956929" accession="SRX6478190">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478190</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956929</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956929: DpnII-Seq-K562-16h-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128474">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128474</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956929</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956929</ID>
          <LABEL>GSM3956929</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956929</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956930" accession="SRX6478191">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478191</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956930</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956930: DpnII-Seq-K562-4h-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128475">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128475</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956930</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956930</ID>
          <LABEL>GSM3956930</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956930</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956931" accession="SRX6478192">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478192</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956931</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956931: DpnII-Seq-K562-3h-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128476">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128476</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956931</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956931</ID>
          <LABEL>GSM3956931</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956931</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956932" accession="SRX6478193">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478193</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956932</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956932: DpnII-Seq-K562-2h-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128477">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128477</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956932</ID>
          <LABEL>GSM3956932</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956932</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956933" accession="SRX6478194">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478194</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956933</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956933: DpnII-Seq-K562-1h-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128478">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128478</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956933</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956933</ID>
          <LABEL>GSM3956933</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956933</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956934" accession="SRX6478195">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478195</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956934</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956934: DpnII-Seq-K562-5min-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128479">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128479</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956934</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>DpnII-Seq  was performed as described in DpnII_Seq Method DpnII-Seq  was performed as described in DpnII_Seq Method</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 4000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956934</ID>
          <LABEL>GSM3956934</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956934</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956935" accession="SRX6478196">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478196</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956935</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956935: 5C-Cells-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128480">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128480</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956935</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>5C was performed as described in “From cells to chromatin: Capturing snapshots of genome organization with 5C technology” (Ferraiuolo et al., 2012). And Decsribe in Method 5C</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956935</ID>
          <LABEL>GSM3956935</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956935</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956936" accession="SRX6478197">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478197</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956936</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956936: 5C-Cells-R2; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128481">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128481</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956936</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>5C was performed as described in “From cells to chromatin: Capturing snapshots of genome organization with 5C technology” (Ferraiuolo et al., 2012). And Decsribe in Method 5C</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956936</ID>
          <LABEL>GSM3956936</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956936</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956937" accession="SRX6478198">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478198</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956937</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956937: 5C-Nulcei-R1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128482">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128482</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956937</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>5C was performed as described in “From cells to chromatin: Capturing snapshots of genome organization with 5C technology” (Ferraiuolo et al., 2012). And Decsribe in Method 5C</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956937</ID>
          <LABEL>GSM3956937</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956937</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM3956938" accession="SRX6478199">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX6478199</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM3956938</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM3956938: 5C-Nulcei-R2; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP215639" refname="GSE134590">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP215639</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS5128483">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS5128483</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM3956938</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>5C was performed as described in “From cells to chromatin: Capturing snapshots of genome organization with 5C technology” (Ferraiuolo et al., 2012). And Decsribe in Method 5C</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>303956938</ID>
          <LABEL>GSM3956938</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM3956938</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
</EXPERIMENT_SET>
