<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE136976" accession="SRP220528">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP220528</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA564140</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE136976</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>ATAC-seq from erythroid cells generated through ex vivo differentiation</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Other"/>
      <STUDY_ABSTRACT>CD34+ Haematopoietic stem cells were differentiated under two ex vivo protocols to generate ATAC-seq data for machine learning of rules underlying open chromatin dynamics. Overall design: CD34+ cells were isolated from peripheral blood from three healthy donors (Two males, one female) and differentiatied ex vivo using two different protocols. The first protocol (P1) uses a 2-phase differentiation and the second protcol (P2) uses a 3-phase differentiation which includes co-culture on a layer of stromal MS-5 cells. ATAC-seq was perfroemd at various days throughout differentiation.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE136976</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_LINKS>
      <STUDY_LINK>
        <XREF_LINK>
          <DB>pubmed</DB>
          <ID>33046896</ID>
        </XREF_LINK>
      </STUDY_LINK>
    </STUDY_LINKS>
    <STUDY_ATTRIBUTES>
      <STUDY_ATTRIBUTE>
        <TAG>parent_bioproject</TAG>
        <VALUE>PRJNA574096</VALUE>
      </STUDY_ATTRIBUTE>
    </STUDY_ATTRIBUTES>
  </STUDY>
</STUDY_SET>
