<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE137309" accession="SRP221439">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP221439</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA565142</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE137309</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Transcriptomic Analysis of Control and PLX4032 Resistant Clones with RNA Sequencing</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>NGS-derived transcriptome profiling (RNA-seq) of control and PLX4032 resistant clones to identify resistance-associated gene-expression changes and pathway enrichments, and to integrate with exome and methylome analysis. Results provide insight into PLX4032 resistance in BRAF V600E melanoma. Overall design: RNA sequencing of 2 controls (parental and parallel) and 15 PLX4032 resistant clones using Illumina HiSeq 4000.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE137309</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_LINKS>
      <STUDY_LINK>
        <XREF_LINK>
          <DB>pubmed</DB>
          <ID>36202798</ID>
        </XREF_LINK>
      </STUDY_LINK>
    </STUDY_LINKS>
  </STUDY>
</STUDY_SET>
