<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE137349" accession="SRP221499">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP221499</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA565223</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE137349</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>The transcriptomic landscape of MAIT cell development in the thymus (C006 RNAseq data set)</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Other"/>
      <STUDY_ABSTRACT>We report the transcriptomic landscape of MAIT cell development by examining thymic immature stage 1 and mature stage 3 MAIT cells from mouse thymus, and thymic immature stage 1, stage 2  mature stage 3 MAIT cells from human thymus using RNAseq. Overall design: We bulk-sorted (100 cell) each MAIT cell subset by flow cytometry and compared the differentially expressed genes (DEGs) between subsets. In addition, we single-cell sorted mouse mature MAIT cell subsets, performed single cell RNAseq comparison of mature thymic MAIT cell populations via clustering analysis to obtain in-depth information about the heterogeneity of functionally diverse mouse MAIT cells.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE137349</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_LINKS>
      <STUDY_LINK>
        <XREF_LINK>
          <DB>pubmed</DB>
          <ID>31757835</ID>
        </XREF_LINK>
      </STUDY_LINK>
    </STUDY_LINKS>
    <STUDY_ATTRIBUTES>
      <STUDY_ATTRIBUTE>
        <TAG>parent_bioproject</TAG>
        <VALUE>PRJNA565220</VALUE>
      </STUDY_ATTRIBUTE>
    </STUDY_ATTRIBUTES>
  </STUDY>
</STUDY_SET>
