SRX7189705 AC2623 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695778 PAT_48_U_Exo_SC AC2623 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189706 AB4584 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695779 PAT_49_EXO AB4584 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189707 AB4536 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695780 PAT_49_P AB4536 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189708 AC2512 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695781 PAT_06_U_exo AC2512 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189709 AC2552 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695782 PAT_49_U_exo AC2552 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189710 AC2624 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695783 PAT_49_U_Exo_SC AC2624 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189711 AB4585 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695784 PAT_50_EXO AB4585 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189712 AB4537 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695785 PAT_50_P AB4537 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189713 AC2553 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695786 PAT_50_U_exo AC2553 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189714 AC2625 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695787 PAT_50_U_Exo_SC AC2625 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189715 AB4586 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695788 PAT_51_EXO AB4586 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189716 AB4538 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695789 PAT_51_P AB4538 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189717 AC2554 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695790 PAT_51_U_exo AC2554 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189718 AC2626 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695791 PAT_51_U_Exo_SC AC2626 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189719 AB4545 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695792 PAT_07_EXO AB4545 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189720 AB4539 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695793 PAT_52_P AB4539 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189721 AC2555 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695794 PAT_52_U_exo AC2555 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189722 AC2627 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695795 PAT_52_U_Exo_SC AC2627 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189723 AB4497 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695796 PAT_07_P AB4497 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189724 AC2513 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695797 PAT_07_U_exo AC2513 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189725 AB4546 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695798 PAT_08_EXO AB4546 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189726 AC2514 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695799 PAT_08_U_exo AC2514 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189727 AB4547 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695800 PAT_09_EXO AB4547 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189728 AC2508 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695801 PAT_01_U_exo AC2508 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189729 AB4548 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695802 PAT_10_EXO AB4548 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189730 AB4500 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695803 PAT_10_P AB4500 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189731 AB4501 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695804 PAT_11_P AB4501 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189732 AC2517 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695805 PAT_11_U_exo AC2517 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189733 AB4550 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695806 PAT_12_EXO AB4550 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189734 AB4502 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695807 PAT_12_P AB4502 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189735 AC2518 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695808 PAT_12_U_exo AC2518 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189736 AB4551 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695809 PAT_13_EXO AB4551 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189737 AB4503 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695810 PAT_13_P AB4503 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189738 AC2519 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695811 PAT_13_U_exo AC2519 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189739 AB4541 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695812 PAT_02_EXO AB4541 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189740 AB4552 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695813 PAT_14_EXO AB4552 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189741 AB4504 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695814 PAT_14_P AB4504 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189742 AC2520 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695815 PAT_14_U_exo AC2520 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189743 AB4553 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695816 PAT_15_EXO AB4553 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189744 AB4505 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695817 PAT_15_P AB4505 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189745 AC2521 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695818 PAT_15_U_exo AC2521 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189746 AB4554 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695819 PAT_16_EXO AB4554 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189747 AB4506 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695820 PAT_16_P AB4506 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189748 AC2522 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695821 PAT_16_U_exo AC2522 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189749 AB4555 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695822 PAT_17_EXO AB4555 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189750 AB4493 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695823 PAT_02_P AB4493 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189751 AC2642 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695824 PAT_17_P AC2642 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189752 AB4556 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695825 PAT_18_EXO AB4556 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189753 AC2524 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695826 PAT_18_U_exo AC2524 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189754 AB4509 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695827 PAT_19_P AB4509 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189755 AC2525 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695828 PAT_19_U_exo AC2525 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189756 AB4558 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695829 PAT_20_EXO AB4558 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189757 AC2526 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695830 PAT_20_U_exo AC2526 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189758 AB4511 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695831 PAT_21_P AB4511 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189759 AC2527 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695832 PAT_21_U_exo AC2527 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189760 AC2647 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695833 PAT_23_P AC2647 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189761 AC2509 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695834 PAT_02_U_exo AC2509 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189762 AC2528 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695835 PAT_23_U_exo AC2528 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189763 AB4561 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695836 PAT_24_EXO AB4561 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189764 AC2529 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695837 PAT_24_U_exo AC2529 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189765 AB4562 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695838 PAT_25_EXO AB4562 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189766 AB4514 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695839 PAT_25_P AB4514 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189767 AB4563 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695840 PAT_26_EXO AB4563 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189768 AB4515 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695841 PAT_26_P AB4515 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189769 AB4564 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695842 PAT_27_EXO AB4564 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189770 AB4517 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695843 PAT_27_P AB4517 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189771 AC2604 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695844 PAT_27_U_Exo_SC AC2604 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189772 AB4542 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695845 PAT_04_EXO AB4542 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189773 AB4565 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695846 PAT_29_EXO AB4565 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189774 AB4518 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695847 PAT_29_P AB4518 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189775 AC2533 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695848 PAT_29_U_exo AC2533 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189776 AC2605 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695849 PAT_29_U_Exo_SC AC2605 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189777 AB4566 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695850 PAT_30_EXO AB4566 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189778 AB4519 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695851 PAT_30_P AB4519 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189779 AC2534 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695852 PAT_30_U_exo AC2534 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189780 AC2606 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695853 PAT_30_U_Exo_SC AC2606 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189781 AB4567 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695854 PAT_31_EXO AB4567 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189782 AB4520 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695855 PAT_31_P AB4520 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189783 AB4494 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695856 PAT_04_P AB4494 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189784 AC2535 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695857 PAT_31_U_exo AC2535 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189785 AC2607 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695858 PAT_31_U_Exo_SC AC2607 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189786 AB4568 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695859 PAT_32_EXO AB4568 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189787 AB4521 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695860 PAT_32_P AB4521 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189788 AC2536 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695861 PAT_32_U_exo AC2536 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189789 AB4522 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695862 PAT_33_P AB4522 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189790 AC2537 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695863 PAT_33_U_exo AC2537 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189791 AC2609 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695864 PAT_33_U_Exo_SC AC2609 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189792 AB4570 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695865 PAT_34_EXO AB4570 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189793 AB4523 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695866 PAT_34_P AB4523 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189794 AC2510 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695867 PAT_04_U_exo AC2510 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189795 AC2538 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695868 PAT_34_U_exo AC2538 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189796 AC2610 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695869 PAT_34_U_Exo_SC AC2610 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189797 AB4571 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695870 PAT_35_EXO AB4571 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189798 AB4524 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695871 PAT_35_P AB4524 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189799 AC2539 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695872 PAT_35_U_exo AC2539 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189800 AC2611 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695873 PAT_35_U_Exo_SC AC2611 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189801 AB4540 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695874 PAT_01_EXO AB4540 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189802 AB4492 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695875 PAT_01_P AB4492 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189803 AC2511 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695876 PAT_05_U_exo AC2511 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189804 AC2544 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695877 PAT_40_U_exo AC2544 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189805 AC2616 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695878 PAT_40_U_Exo_SC AC2616 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189806 AB4577 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695879 PAT_41_EXO AB4577 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189807 AB4529 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695880 PAT_41_P AB4529 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189808 AC2545 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695881 PAT_41_U_exo AC2545 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189809 AC2617 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695882 PAT_41_U_Exo_SC AC2617 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189810 AB4578 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695883 PAT_42_EXO AB4578 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189811 AB4530 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695884 PAT_42_P AB4530 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189812 AC2546 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695885 PAT_42_U_exo AC2546 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189813 AC2618 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695886 PAT_42_U_Exo_SC AC2618 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189814 AB4544 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695887 PAT_06_EXO AB4544 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189815 AB4531 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695888 PAT_43_P AB4531 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189816 AC2547 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695889 PAT_43_U_exo AC2547 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189817 AB4572 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695890 PAT_36_EXO AB4572 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189818 AB4525 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695891 PAT_36_P AB4525 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189819 AC2540 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695892 PAT_36_U_exo AC2540 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189820 AC2612 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695893 PAT_36_U_Exo_SC AC2612 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189821 AB4495 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695894 PAT_05_P AB4495 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189822 AB4526 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695895 PAT_37_P AB4526 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189823 AC2541 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695896 PAT_37_U_exo AC2541 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189824 AC2613 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695897 PAT_37_U_Exo_SC AC2613 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189825 AB4574 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695898 PAT_38_EXO AB4574 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189826 AB4527 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695899 PAT_38_P AB4527 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189827 AC2542 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695900 PAT_38_U_exo AC2542 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189828 AC2614 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695901 PAT_38_U_Exo_SC AC2614 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189829 AB4575 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695902 PAT_39_EXO AB4575 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189830 AC2543 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695903 PAT_39_U_exo AC2543 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189831 AC2615 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695904 PAT_39_U_Exo_SC AC2615 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189832 AC2619 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695905 PAT_43_U_Exo_SC AC2619 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189833 AB4580 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695906 PAT_44_EXO AB4580 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189834 AC2643 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695907 PAT_44_P AC2643 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189835 AC2548 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695908 PAT_44_U_exo AC2548 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189836 AC2620 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695909 PAT_44_U_Exo_SC AC2620 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189837 AB4581 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695910 PAT_46_EXO AB4581 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189838 AB4533 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695911 PAT_46_P AB4533 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189839 AC2549 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695912 PAT_46_U_exo AC2549 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189840 AB4496 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695913 PAT_06_P AB4496 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189841 AC2621 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695914 PAT_46_U_Exo_SC AC2621 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189842 AB4534 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695915 PAT_47_P AB4534 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189843 AC2550 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695916 PAT_47_U_exo AC2550 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189844 AC2622 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695917 PAT_47_U_Exo_SC AC2622 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189845 AB4583 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695918 PAT_48_EXO AB4583 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189846 AC2646 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695919 PAT_48_P AC2646 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000 SRX7189847 AC2551 SRP230732 bp0 Plasma and urinary exosomal smaples were obtained by ultracentrifugation then total RNA were extracted from exosomal and plasma samples and stored at -80C until library preparation. Individual samples were analyzed by random sequencing of small RNAs. Single patient libraries were prepared from 2 L of total RNA from each condition (total plasma urine exosomes or plasma exosomes) using CleanTag Small RNA library preparation kit (TriLink Biotechnologies US) adapting manufacturers protocol to very low input samples (Shore 2016). Briefly after adapter ligation and cDNA amplification containing 1 of 48 index sequences libraries were size-selected (138155 bp fragments) on a 15% Novex TBE PAGE gel (Life Technologies US) purified re-amplified 10 cycles quantified by RT-qPCR and pooled for multiplexed sequencing. Pools were normalized to 2 nM and sequenced on the HiSeq 2000 platform (Illumina US) with a 50-cycle single read mode (CNAG Barcelona Spain). SRS5695920 PAT_48_U_exo AC2551 miRNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2000