LOCUS       DAUDWO010000001        74663 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.001, whole genome shotgun sequence.
ACCESSION   DAUDWO010000001 DAUDWO010000000
VERSION     DAUDWO010000001.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 74663)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 74663)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..74663
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.001"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            219..1454
                     /gene="arcA"
                     /locus_tag="VHC05_000001"
     CDS             219..1454
                     /gene="arcA"
                     /locus_tag="VHC05_000001"
                     /EC_number="3.5.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine deiminase"
                     /protein_id="HEQ5401357.1"
                     /translation="MTAQTPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDI
                     PFLEDAQKEHDAFAQALRDEGIEVLYLETLAAESLVTPEIREAFIDEYLSEANIRGRA
                     TKKAIRELLMAIEDNQELIEKTMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPN
                     LYFTRDPFATIGTGVSLNHMFSETRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTR
                     IEGGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHL
                     DTVFTMVDYDKFTIHPEIEGDLRVYSVTYDNEELHIVEEKGDLAELLAANLGVEKVDL
                     IRCGGDNLVAAGREQWNDGSNTLTIAPGVVVVYNRNTITNAILESKGLKLIKIHGSEL
                     VRGRGGPRCMSMPFEREDI"
     gene            1554..1895
                     /locus_tag="VHC05_000002"
     CDS             1554..1895
                     /locus_tag="VHC05_000002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEQ5401358.1"
                     /translation="MTDKFDANDETRTVYAVVYDNDQPVSTGQFLAETKIEARLTRIV
                     TLADYCGCGYGAKVTEALETYTRREGFYQLTIHSELTAQTFYENLGYQTYGSKYLEDG
                     EYCQSLVKTIA"
     gene            2019..3032
                     /gene="argF"
                     /locus_tag="VHC05_000003"
     CDS             2019..3032
                     /gene="argF"
                     /locus_tag="VHC05_000003"
                     /EC_number="2.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000195397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine carbamoyltransferase"
                     /protein_id="HEQ5401359.1"
                     /translation="MTQVFQGRSFLAEKDFTRAELEYLIDFSAHLKDLKKRGVPHHYL
                     EGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRMF
                     DGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVKENFGKLEGLTLVY
                     CGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEEEIVTLAEGYAKESGARILITEDA
                     DEAVKGADVLYTDVWVSMGEEDKFKERVELLQPYQVNMDLVQKAGNDKLIFLHCLPAF
                     HDTNTVYGKDVAEKFGVKEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLFI
                     PKV"
     gene            3202..4695
                     /locus_tag="VHC05_000004"
     CDS             3202..4695
                     /locus_tag="VHC05_000004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfcC family protein"
                     /protein_id="HEQ5401360.1"
                     /translation="MTEEKKRGFRIPSSYTVLFIIIAIMAVLTWFIPAGAYETAKGGG
                     VISGTYKTVASNPQGFFDILMAPVRGMLGVEGTDGAIQVSFFILMVGGFLGVVNKTGA
                     LDTGIASVVRKNKGREKMLIAILIPLFALGGTTYGMGEETMAFYPLLIPVMIAVGFDS
                     IVAVAIILIGSQIGCLASTINPFATGVAADAAGVSIADGMIWRVIQWVILVGMSIWFV
                     YNYASKIEEDPSKSLVADKEEEHKELFQLQNSGEDLNKRQRNVLTIFTLTFVIMILSL
                     IPWEDFGIKFFTNINTWLTTMPILGGVIGKTMGAFGTWYFPEITMLFIMMGVLVAIVY
                     RMSEEDFFSSFLTGAGEFLGVAMICAIARGIQVIMNGGMITATILHLGETSLSGLSSQ
                     VFVILAYIFYLPMSFLIPSTSGLAGATMGIMAPLGQFSNVPAHLVITAFQSASGILNM
                     ISPTSAIVMGALALGRVDLGTWWKFIGKFIVMVMLVSVLLLVVATFF"
     gene            4712..6043
                     /locus_tag="VHC05_000005"
     CDS             4712..6043
                     /locus_tag="VHC05_000005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase"
                     /protein_id="HEQ5401361.1"
                     /translation="MESYITPKHQEACVAAIKQIVSYPSVCHEGENGTPFGQAIQDVL
                     EATLDLCQGLGFHTYIDPEGYYGYAELGDQKEVLAILCHLDVVPEGDRQLWKTDPFDC
                     VEADGCLFGRGTQDDKGPTMMALFATKALIDAGVTFNKRIRFIFGTDEETLWRCMNRY
                     NDVEEQATFGFAPDSSFPLTYAEKGLLQAKLVGKGCDKLSLEIGQAYNVVPARASYKG
                     NKLEALQKELDKLGFEYVVKEGELTVYGLAQHAKDAPDGINAMIRLAKALVVLEPNKT
                     LDFLANVIDEDGRALNIFGRIEDEPSGKLSFNAAGLTLTKDKAEIRLDIRIPVLADKE
                     KLVQQLSQKAQEYGLTYEEFDYLAPLYVPLDSELVTTLLSVYRKKTGDQSPAQSSGGA
                     TFARTMKNCVAFGALFPDAVQTEHQENEHIVLADAYRAMDIYAEAIYRLTR"
     gene            6063..7013
                     /gene="arcC"
                     /locus_tag="VHC05_000006"
     CDS             6063..7013
                     /gene="arcC"
                     /locus_tag="VHC05_000006"
                     /EC_number="2.7.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012679157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamate kinase"
                     /protein_id="HEQ5401362.1"
                     /translation="MTKQKIVVALGGNAILSTDASAKAQQEALMSTSKSLVKLIKEGH
                     EVIVTHGNGPQVGNLLLQQAAADSEKNPAMPLDTCVAMTEGSIGFWLVNALDNELQAQ
                     GIQKEVAAVVTQVIVDAKDPAFENPTKPIGPFLTEEDAKKQMSESGASFKEDAGRGWR
                     KVVPSPKPVGIKEANVIRSLVDSGVVVVSAGGGGVPVVEDATSKTLTGVEAVIDKDFA
                     SQTLSELVDADLFIVLTGVDNVYVNFNKPDQTKLEEVTVSQMKEYITQDQFAPGSMLP
                     KVEAAIAFVENKPNAKAIITSLENIDNVLSANAGTQIIAG"
     gene            7326..8318
                     /locus_tag="VHC05_000007"
     CDS             7326..8318
                     /locus_tag="VHC05_000007"
                     /EC_number="6.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016502595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--ammonia ligase"
                     /protein_id="HEQ5401363.1"
                     /translation="MKKSFIHQQEEISFVKNTFTQYLIAKLDVVEVQGPILSRVGDGM
                     QDNLSGTENPVSVNVLKIPNATFEVVHSLAKWKRHTLARFGFNEGEGLVVNMKALRPD
                     EDSLDQTHSVYVDQWDWEKVIPDGKRNLAYLKETVETIYKVIRLTELAVEARYDIEAV
                     LPKKITFIHTEELVAKYPDLTPKERENAITKEFGAVFLIGIGGVLPDGKPHDGRAPDY
                     DDWTTETENGYHGLNGDILVWNDQLGSAFELSSMGIRVDEEALKRQVEMTGDQDRLAF
                     DWHKSLLNGLFPLTIGGGIGQSRMVMFLLRKKHIGEVQTSVWPQEVRDSYDNIL"
     gene            8441..8980
                     /gene="rsmD"
                     /locus_tag="VHC05_000008"
     CDS             8441..8980
                     /gene="rsmD"
                     /locus_tag="VHC05_000008"
                     /EC_number="2.1.1.171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="HEQ5401364.1"
                     /translation="MRVVSGEFGGRPLKTLDGKITRPTSDKVRGAIFNMIGPYFNGGR
                     VLDLFAGSGGLAIEAVSRGMSAAVLVEKNRKAQAIIQDNIIMTKAENRFTLLKMEAER
                     AIDCLTGRFDLVFLDPPYAKETIVATIEALAAKNLLSEQVMVVCETDKTVLLPKEIAT
                     LGIWKEKIYGISKVTVYVN"
     gene            8970..9461
                     /gene="coaD"
                     /locus_tag="VHC05_000009"
     CDS             8970..9461
                     /gene="coaD"
                     /locus_tag="VHC05_000009"
                     /EC_number="2.7.7.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020905327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="HEQ5401365.1"
                     /translation="MLTKIGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKK
                     SYFKLEVRKAMLTQALADFTNVIVVTSHERLAIDVAKELRVTHLIRGLRNATDFEYEE
                     NLEYFNHLLAPNIETVYLISRNKWQALSSSRVRELIHFQSSLEGLVPQSVIAQVEKMN
                     EKT"
     gene            9448..10485
                     /locus_tag="VHC05_000010"
     CDS             9448..10485
                     /locus_tag="VHC05_000010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PDZ domain-containing protein"
                     /protein_id="HEQ5401366.1"
                     /translation="MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTV
                     LQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTPFTEISTAEDTTGGYSDADFLRI
                     NQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
                     QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSV
                     NSEDTVIFSTKGVGGPSAGLMFTLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGG
                     AGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRAAKRLKTKMKIVPVT
                     TVQEALVYLRK"
     gene            10899..11876
                     /locus_tag="VHC05_000011"
     CDS             10899..11876
                     /locus_tag="VHC05_000011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEQ5401367.1"
                     /translation="MVTIKQVAEEAGVSRSTVSRYISQKGYVSDDARHKIKAAIAKLH
                     YTPNVLAQSLKTKKNQLVGLLLPDISNPFFPRLARGAEEYLKEKGYRVMLGNISDSEA
                     LEEEYVHVLLQSNAAGIITTHDFTKRYPTLAIPVVVVDRVDQETQYGVFSDNRAGGLL
                     AAQTVWQAGAKEVLLIRGPLDNAENINERFEASFSYLQKQDVTMYVCDSQNFDFESIQ
                     LEASYNLKCYPTIDSIIAPSDIHAIAYIHELHSQGKKIPQDVQIIGYDDILMSQFIYP
                     SLSTIHQSSYLMGRYAAELVYTIASQLTVKANRIKLPVHYVERETIRKR"
     gene            12300..12944
                     /locus_tag="VHC05_000012"
     CDS             12300..12944
                     /locus_tag="VHC05_000012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1027 domain-containing protein"
                     /protein_id="HEQ5401368.1"
                     /translation="MDFSERCQMKKEISPEMYNYNKFPGPKFIHFEEQVKAEGIDLLL
                     LEDVKNAFDTTSFGQRYTEVLLKYDYIVGDWGNEQLRLKGFYKDSDDIKKTNRISRLE
                     DYIKEFCNFGCAYFVLENLHPQDIKFEEERQPRRKKSPKSKSNRRKPNYSNQQPATPK
                     SKSKRVSKEKQPENQAFTSQKRRSNTKHKEKSKRNQTSQLNTKISHFIIRKKDK"
     gene            12948..14027
                     /gene="rlmN"
                     /locus_tag="VHC05_000013"
     CDS             12948..14027
                     /gene="rlmN"
                     /locus_tag="VHC05_000013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="HEQ5401369.1"
                     /translation="MKPSIYSLTRDELIAWAVERGQKQFRATQIWDWLYKKRVQSFEE
                     MTNISKDFVSILNDSFCVNPLKQRVVQESADGTVKYLFELPDGMLIETVLMRQHYGHS
                     VCVTTQVGCNIGCTFCASGLIKKQRDLNSGEITAQIMLVQKYFDDRKQGERVSHVVVM
                     GIGEPFDNYKNVMCFLRVINDDNGLAIGARHITVSTSGLAHKIRDFANEGVQVNLAVS
                     LHAPNNDLRSSIMRVNRSFPLEKLFSAIEYYIEKTNRRVTFEYIMLNEVNDSIKQAQE
                     LADLTKTIRKLSYVNLIPYNPVSEHDQYSRSPKERVLAFYDVLKKNGVNCVVRQEHGT
                     DIDAACGQLRSKTMKKDREKVTATK"
     gene            complement(14109..14736)
                     /locus_tag="VHC05_000014"
                     /pseudo
     CDS             complement(14109..14736)
                     /locus_tag="VHC05_000014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922497.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
     gene            14964..15491
                     /locus_tag="VHC05_000015"
     CDS             14964..15491
                     /locus_tag="VHC05_000015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012997888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA starvation/stationary phase protection
                     protein"
                     /protein_id="HEQ5401370.1"
                     /translation="MTNTLVENIYASVTHNISKKEASKNEKTKAVLNQAVADLSVAAS
                     IVHQVHWYMRGPGFLYLHPKMDELLDSLNANLDEMSERLITIGGAPYSTLAEFSKHSK
                     LDEAKGTYDKTVAQHLARLVEVYLYLSSLYQVGLDITDEEGDAGTNDLFTAAKTEAEK
                     TIWMLQAERGQGPAL"
     gene            15633..15836
                     /locus_tag="VHC05_000016"
     CDS             15633..15836
                     /locus_tag="VHC05_000016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqgQ family protein"
                     /protein_id="HEQ5401371.1"
                     /translation="MKTLYDVQQLLKNFGIFVYLGKRLYDIEMMKIELQRLYDSGLLD
                     KRDYLNAELILRREHRLELEKEG"
     gene            15841..16812
                     /locus_tag="VHC05_000017"
     CDS             15841..16812
                     /locus_tag="VHC05_000017"
                     /EC_number="2.7.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family glucokinase"
                     /protein_id="HEQ5401372.1"
                     /translation="MSQKLLGIDLGGTTIKFGILTAAGEVQEKWAIETNILEGGKHIV
                     PDIIASIKHRLDLYDLSSADFVGIGMGSPGAVDRDTNTVTGAFNLNWKETQEVGSVVE
                     KELGIPFAIDNDANVAALGERWVGAGENNPDVVFMTLGTGVGGGIIADGNLIHGVAGA
                     GGEIGHMIVEPENGFACTCGSHGCLETVASATGVVKVARLLAEAYEGDSAIKAAIDNG
                     EGVTSKDIFMAAEAGDSFADSVVEKVGYYLGLASANISNILNPDSVVIGGGVSAAGEF
                     LRSRIEKYFVTFTFPQVRYSTKIKIAELGNDAGIIGAASLARQFITK"
     gene            16822..17211
                     /locus_tag="VHC05_000018"
     CDS             16822..17211
                     /locus_tag="VHC05_000018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEQ5401373.1"
                     /translation="MSPITLILWLLLVGIVGYHTWNYFSFRKMAKQVDNETFKDVMRQ
                     GQLIDLREPAAFRTKHILGARNFPAQQFDAAIKGLRKDKPVLIYENMRPQYRVPAVKK
                     LKKAGFEDVYVLKDGIDYWDGKVKQTT"
     gene            17394..19235
                     /gene="typA"
                     /locus_tag="VHC05_000019"
     CDS             17394..19235
                     /gene="typA"
                     /locus_tag="VHC05_000019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translational GTPase TypA"
                     /protein_id="HEQ5401374.1"
                     /translation="MTNLRNDIRNVAIIAHVDHGKTTLVDELLKQSHTLDERKELQER
                     AMDSNDLEKERGITILAKNTAVAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVLVV
                     DAYEGTMPQTRFVLKKALEQNLIPIVVVNKIDKPSARPAEVVDEVLELFIELGADDEQ
                     LEFPVVYASAINGTSSLSDDPADQEHTMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLD
                     YNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAG
                     DLIAVSGMEDIFVGETITPTDCVEALPILRIDEPTLQMTFLVNNSPFAGREGKWITSR
                     KVEERLLAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEV
                     IIKEIDGVKCEPFERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLIFLIPA
                     RGLIGYSTEFLSMTRGYGIMNHTFDQYLPVVQGEIGGRHRGALVSIENGKATTYSIMR
                     IEERGTIFVNPGTEVYEGMIVGENSRDNDLGVNITTAKQMTNVRSATKDQTAVIKTPR
                     ILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAARDKANKKKKSAE"
     gene            19357..19608
                     /locus_tag="VHC05_000020"
     CDS             19357..19608
                     /locus_tag="VHC05_000020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3165 family protein"
                     /protein_id="HEQ5401375.1"
                     /translation="MFYLIMAVLIISYYLYMAPKSVRNTLGMIGLVGLVALLIVLAGL
                     SFIKIMQTPPEFFIGMGMVALGYFALKDVRKMTKKPRVK"
     gene            19964..21322
                     /locus_tag="VHC05_000021"
     CDS             19964..21322
                     /locus_tag="VHC05_000021"
                     /EC_number="6.3.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /protein_id="HEQ5401376.1"
                     /translation="MKVISNFQNKKILILGLAKSGEAAAKLLTKLGALVTVNDSKPFD
                     QNPAAQALLEEGIKVICGSHPVELLDENFEYMVKNPGIPYDNPMVKRALAKEIPILTE
                     VELAYFVSEAPIIGITGSNGKTTTTTMIADVLNAGGQSALLSGNIGYPASKVVQKAIA
                     GDTLVMELSSFQLVGVNAFRPHIAVITNLMPTHLDYHGSFEDYVAAKWMIQAQMTESD
                     YLILNANQEISATLAKTTKATVIPFSTQKVVDGAYLNDGILYFKEQAIIAATDLGVPG
                     SHNIENALATIAVAKLSGIADDIIAQCLSHFGGVKHRLQRVGQIKDITFYNDSKSTNI
                     LATQKALSGFDNSRLILIAGGLDRGNEFDDLVPDLLGLKQMIILGESAERMKRAANKA
                     EVSYLEARSVAEATELAFKLAQTGDTILLSPANASWDMYPNFEVRGDEFLATFDCLRG
                     DA"
     gene            21322..22404
                     /locus_tag="VHC05_000022"
     CDS             21322..22404
                     /locus_tag="VHC05_000022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine--N-acetylmuramyl-
                     (pentapeptide) pyrophosphoryl-undecaprenol
                     N-acetylglucosamine transferase"
                     /protein_id="HEQ5401377.1"
                     /translation="MPKKILFTGGGTVGHVTLNLILIPKFIKDGWEVHYIGDKNGIEH
                     TEIEKSGLDVTFHAIATGKLRRYFSWQNLADVFKVALGLLQSLFIVAKLRPQALFSKG
                     GFVSVPPVVAAKLLGKPVFIHESDRSMGLANKIAYKFATTMYTTFEQEDQLSKVKHLG
                     AVTKVFKDTNQMPESTQLEAVKEYFSRDLKTLLFIGGSAGAHVFNQFISDHPELKQRY
                     NIINITGDPHLNELSSHLYRVDYVTDLYQPLMAMADLVVTRGGSNTLFELLAMAKLHL
                     IVPLGKEASRGDQLENATYFEKRGYAKQLQEPDLTLHNFDQAMADLFEHQADYEATML
                     ATKEIQSPDFFYDLLRADISSAIKEK"
     gene            22405..23553
                     /locus_tag="VHC05_000023"
     CDS             22405..23553
                     /locus_tag="VHC05_000023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsQ/DivIB"
                     /protein_id="HEQ5401378.1"
                     /translation="MAKDKEKQSDDKLVLTEWQKRNIEFLKKKKQQAEEEKKLKEKLL
                     SDKKAQQQAQNASEAVELKTDEKTDSQEIESETTSKPKKPKKVRQPKEKSATQIAFQK
                     SLPVLLGALLLMAVSIFMITPYSKKKEFSVRGNHQTNLDELIKASKVKASDYWLTLLT
                     SPGQYERPILRTIPWVKSVHLSYQFPNHFLFNVIEFEIIAYAQVENGFQPILENGKRV
                     DKVRASELPKSFLILNLKDEKAIQQLVKQLTTLPKKLVKNIKSVSLANSKTTADLLLI
                     EMYDGNVVRVPQSQLTLKLPYYQKLKKNLENDSIVDMEVGIYTTTQEIENQPEVPLTP
                     EQNAADKEGDKPGEHQEQTDNDSETPANQSSPQQAPPFPETVLEQAHG"
     gene            23764..25128
                     /gene="ftsA"
                     /locus_tag="VHC05_000024"
     CDS             23764..25128
                     /gene="ftsA"
                     /locus_tag="VHC05_000024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsA"
                     /protein_id="HEQ5401379.1"
                     /translation="MARNGFFTGLDIGTSSIKVLVAEFISGEMNVIGVSNVPSTGVKD
                     GIIIDIEAAATAIKTAVEQAEEKAGMTIEKVNVGLPANLLQIEPTQGMIPVPSESKEI
                     KDEDVDSVVKSALTKSITPEREVISLVPEEFIVDGFQGIRDPRGMMGIRLEMRGLIYT
                     GPSTILHNLRKTVERAGIKVENIIISPLAMAKTILNEGEREFGATVIDMGGGQTTVAS
                     MRAQELQYTNIYAEGGEYITKDISKVLKTSLAIAEALKFNFGQAEISEASITETVKVD
                     VVGSEEPVEVTERYLSEIISARIRHILDRVKQDLERGRLLDLPGGIVLIGGGAIMPGV
                     VEIAQEIFGVTVKLHVPNQVGIRNPMFSNVISLVEYVGMMSEVDVLAQTAVSGEELLR
                     RKPIDFSGQESYLPDYDDSRRPESTIGYEQQASQTAYDSQVPSDPKQKISERVRGIFG
                     SMFD"
     gene            25152..26471
                     /gene="ftsZ"
                     /locus_tag="VHC05_000025"
     CDS             25152..26471
                     /gene="ftsZ"
                     /locus_tag="VHC05_000025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsZ"
                     /protein_id="HEQ5401380.1"
                     /translation="MAFSFDTASIQGAIIKVIGVGGGGGNAINRMIDEGVAGVEFIAA
                     NTDIQALSSSKAETVIQLGPKLTRGLGAGGQPEVGRKAAEESEEILTEALTGADMVFI
                     TAGMGGGSGTGAAPVIARIAKSLGALTVAVVTRPFGFEGNKRGNFAIEGIEELREQVD
                     TLLIISNNNLLEIVDKKTPLLEALSEADNVLRQGVQGITDLITSPGLINLDFADVKTV
                     MANKGNALMGIGIGSGEERIVEAARKAIYSPLLETTIDGAQDVIVNVTGGLDMTLTEA
                     EEASEIVGQAAGQGVNIWLGTSIDDTMKDDIRVTVVATGVRQEKAEQVSGFRQPRTFT
                     QTNAQQVAGAQYASDQAKQSVQPGFDRRSNFDFDMGESREIPSAQKVISNHNQNQGSA
                     FGNWDLRRDNISRPTEGELDNHLNMSTFSANDDSDDELETPPFFKNR"
     gene            26474..27145
                     /locus_tag="VHC05_000026"
     CDS             26474..27145
                     /locus_tag="VHC05_000026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggS family pyridoxal phosphate-dependent
                     enzyme"
                     /protein_id="HEQ5401381.1"
                     /translation="MDLLTNKKKIFETIRLSTEAANRTNDSVSVIAVTKYVDSTIAGQ
                     LIEAGIEHIAENRVDKFLEKYDALKYMPVKWHLIGTLQRRKVKEVINYVDYFHALDSV
                     RLALEINKRADHPVKCFLQVNISKEESKHGFNISEIDEAIEEIGKMEKIQLVGLMTMA
                     PANASKESIITIFRQANQLRKNLQLKKRKNMPFTELSMGMSNDYPIAIQEGSTFIRIG
                     RAFFH"
     gene            27157..27813
                     /locus_tag="VHC05_000027"
     CDS             27157..27813
                     /locus_tag="VHC05_000027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein SepF"
                     /protein_id="HEQ5401382.1"
                     /translation="MAFKDTFNKMISYFDTDEVNEVEEDVTASTDNVIPRSQQSVRAS
                     SHPKQEPRNNHVQQDHQARSQEQTRSQMHPKHGTSERYYQQSQPKEGHEMVDRRKRMS
                     TSGIANRREQYQQSTCSDQTTIALKYPRKYEDAQEIVDLLIVNECVLIDFQFMLDAQA
                     RRCLDFIDGASKVLYGSLQKVGSSMYLLAPSNVSVNIEEMTIPHTTQDIGFDFDMKRR
                     "
     gene            27818..28072
                     /locus_tag="VHC05_000028"
     CDS             27818..28072
                     /locus_tag="VHC05_000028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggT family protein"
                     /protein_id="HEQ5401383.1"
                     /translation="MILILSILLRLIKVYTYLLIAYALMSWFPGAYDSKIGRLISGIV
                     EPILKPFRAFNLQFAGLDFTIFVVIISLNFLAQVLVRVFI"
     gene            28072..28863
                     /locus_tag="VHC05_000029"
     CDS             28072..28863
                     /locus_tag="VHC05_000029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein"
                     /protein_id="HEQ5401384.1"
                     /translation="MVSHSKIYQHFHQEEYSFIDRMSDMINRVEDYYLLEVTEFLNPR
                     EVMILKSLIALTDLKMFVSTDYYPSEYGRVIIAPGYYDLEQSDFQIALVEISYQAKFN
                     QLTHSQILGTLINELGVKRNLFGDVFVEMGYAQLMIKRELLDYFLGTITKIAKTSVKL
                     REVNFDQLIRSIDNNQTLDILVSSFRLDGVVATILKKSRTQVIALIEANKIKVNYRLA
                     NKASDNLVIGDMVSIRGHGRFTLLADNGVTKHGKQKITLSKMIHK"
     gene            28873..29631
                     /locus_tag="VHC05_000030"
     CDS             28873..29631
                     /locus_tag="VHC05_000030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DivIVA domain-containing protein"
                     /protein_id="HEQ5401385.1"
                     /translation="MALTTLEIKDKTFKTKFRGYCEEEVNEFLDIVVDDYEALVRKNR
                     DNEARIKDLEEKLSYFDEMKESLSQSVILAQETAEKVKATANAEATNLVSKATYDAQH
                     LLDESKAKANQMLRDATDEAKRVAIETEELKRQTRVFHQRLISSIESQLSLSNSPEWD
                     ELLQPTAIYLQNSDDAFKEVVKTVLNEDIPESDDSASFDATRQFTPEELEELQRRVDE
                     SNKELEAYQLDSQSDSTTEPEVNLSETQTFKLNI"
     gene            29904..32705
                     /locus_tag="VHC05_000031"
     CDS             29904..32705
                     /locus_tag="VHC05_000031"
                     /EC_number="6.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoleucine--tRNA ligase"
                     /protein_id="HEQ5401386.1"
                     /translation="MKLKETLNLGKTAFPMRAGLPNKEPQWQAAWEQAELYKKRQELN
                     AGKPAFHLHDGPPYANGNIHVGHALNKISKDIIVRSKSMSGFQAPYVPGWDTHGLPIE
                     QVLAKQGIKRKEMDLAEYLEMCRQYALSQVDKQRNDFKRLGVSADWENPYVTLDPQFE
                     ADQIRVFGAMAEKGYIYRGAKPVYWSWSSESALAEAEIEYHDIDSTSLYYANKVKDGK
                     DILDTNTYIVVWTTTPFTVTASRGLTVGPDMDYLVVKPAGSDRQYVVAEGLLDSLAGK
                     FGWESFETLASHKGADLEYIVTEHPWDTDVEELVILGDHVTLESGTGIVHTAPGFGED
                     DYNVGTKYKLEVAVTVDERGLMMENAGPDFHGQFYNKVTPIVIDKLGDLLLAQEVINH
                     SYPFDWRTKKPIIWRAVPQWFASVSDFRQDILDEIEKTTFHPSWGETRLYNMIRDRGD
                     WVISRQRAWGVPLPIFYAEDGTAIMTKEVTDHVADLFQENGSIIWWQKEAKDLLPEGF
                     THPGSPNGEFTKETDIMDVWFDSGSSWNGVMNARENLSYPADLYLEGSDQYRGWFNSS
                     LITSVAVNGHAPYKAILSQGFVLDGKGEKMSKSKGNIISPNDVAKQYGADILRLWVAS
                     VDTDNDVRVSMEILGQVSETYRKIRNTLRFLIANTSDFNPVTDTVAYADLGAVDKYMT
                     IVFNQLVATITDAYERYDFMAIYKAVVNFVTVDLSAFYLDFAKDVVYIEAANSLERRR
                     MQTVFYDILVKITKLLTPILPHTTEEIWSYLEYESEAFVQLAEMPVAETFSAQEDILE
                     AWSAFMTLRTQAQKALEEARNAKIIGKSLEAHLTIYASEEVKTLLTALDSDIALLLIV
                     SQLTIADLADAPADAVAFEGIAFMVEHAIGEVCERSRRIDPTTRMRSYNAFVCDHSAK
                     IIEENFPEAVAEGFEESGK"
     gene            complement(32970..33272)
                     /locus_tag="VHC05_000032"
     CDS             complement(32970..33272)
                     /locus_tag="VHC05_000032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1827 family protein"
                     /protein_id="HEQ5401387.1"
                     /translation="MRLINTTSSHPELIRNQLKNTDAYLVEVYSAGNTDVIFTQAPKH
                     YELLISNKYRAIKEDELDIIREFFLKRKIDPKIVIPGQSKTLHTNNLIEISFQTSV"
     gene            complement(33323..33778)
                     /locus_tag="VHC05_000033"
     CDS             complement(33323..33778)
                     /locus_tag="VHC05_000033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEQ5401388.1"
                     /translation="MMIPTFGHKNAHNDYVTRYGVYAIIPNHEQTKIILVQAPNGSWF
                     LPGGEIEAGEGQLQALERELIEELGFSATIGSYYGQADEYFYSRHRDTHFYHPAYLYE
                     VTAFQAVSKPLEDFNNLGWFSPIEAIAKLKRESHQWGVKEWQKKHHSTN"
     gene            complement(33906..36188)
                     /locus_tag="VHC05_000034"
     CDS             complement(33906..36188)
                     /locus_tag="VHC05_000034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560820.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEQ5401389.1"
                     /translation="MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSI
                     LNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLPNTPPTQAGQNGNGGGRYGGNYN
                     GQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRIIEILNRRTKNN
                     PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERM
                     QKLMEEIRNRKDVILFIDEIHEIVGAGSAGDGNMDAGNILKPALARGELQLVGATTLN
                     EYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHHVKYSPAAIEAAAHL
                     SNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYE
                     RAAYFRDQITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVN
                     LANDLKAHVIGQDDAVDKIAKAIRRNRVGLGTPNRPIGSFLFVGPTGVGKTELSKQLA
                     IELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPYSLILLD
                     EVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAR
                     EGRTSSVLGELSNFFSPEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIH
                     LDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDYYLEHPTEKQLRALMTNSE
                     NITIKAVKEGDSFLNEKSLD"
     gene            36485..36715
                     /locus_tag="VHC05_000035"
     CDS             36485..36715
                     /locus_tag="VHC05_000035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003105222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YkuJ family protein"
                     /protein_id="HEQ5401390.1"
                     /translation="MESHLVRIINRLELMVTDGGNLKRNFERDGVVVAEVAFSNDPEN
                     GPVFTLRDVEARESYSFDSIDLIAMEIYDLLY"
     gene            36842..37528
                     /locus_tag="VHC05_000036"
     CDS             36842..37528
                     /locus_tag="VHC05_000036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEQ5401391.1"
                     /translation="MDLSFLPKYWAYFNYGVLVTIMISVSVVFFGTLIGVLVTLIKRS
                     HVKPLTWVVNLYVWIFRGTPMVVQIMIAFAWMHFNNMPTIGFGVLDLDFSRLLPGIII
                     ISLNSGAYISEIVRAGIEAVPKGQLEAAYSLGIRPQNAMRYVILPQAFKNILPALGNE
                     FITIIKDSALLQTIGVMELWNGAQSVVTATYSPISPLLVAAFYYLMVTTVMAQLLAVL
                     ERHMAQGGNH"
     gene            37528..38262
                     /locus_tag="VHC05_000037"
     CDS             37528..38262
                     /locus_tag="VHC05_000037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401392.1"
                     /translation="MTEAIISIKDLHKYYGHNEVLKGIDLDIMPGEVVVIIGPSGSGK
                     STLLRTMNLLEVPTKGQIRFEGIDITDKKNDIFSMREKMGMVFQQFNLFPNMTVLENI
                     TLSPIKTKGMAKAEADKTALSLLDKVGLSEKAKAYPASLSGGQQQRIAIARGLAMDPD
                     VLLFDEPTSALDPEMVGEVLAVMQDLAKSGMTMVIVTHEMGFAKEVADRVMFMDGGVI
                     VEEGSPNQLFDLTKEERTKDFLSRVL"
     gene            38410..39819
                     /locus_tag="VHC05_000038"
     CDS             38410..39819
                     /locus_tag="VHC05_000038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="HEQ5401393.1"
                     /translation="MVSVMWFRRDLRIDDQKALAHVIASQSPTLCVFQFNKEQLNLLH
                     SRNQSSFITSVLAFRKLLKCEGIDLYLMYGDLMTCFEQLLTQLKDWTDVYFNYDESGY
                     GRLRDQKAAQFFKKNGIAVHTYQDHYLHGSQEIINQSGQPYKVFTPYYRIWQNYPKET
                     PIKVELSQGRWLNLETPDDVLRTVESFKDEKYQDVATFDEASKQLNRFIQDQLAAYHA
                     NRDFPAQLGTSRLSPFLRIGAIGIRTVYHAVRQAPNSLGQATFLKELAWRDFYNMVYV
                     AYPDQKTQPIQKAFSQIEWVNNPDWFQLWKEGKTGYPIVDAAMLQLQKTGWMHNRLRM
                     IVASFLTKDLLCDWRLGEQYFQQQLIDYDAASNIGGWQWAASTGTDAVPYFRIFNPVT
                     QGKRFDPKGEFIKAYLPQLEHVPEKYLHEPWKMPKNLQESVSCIIGTDYPQPIVDHAK
                     QREQAIAKYEWAKEKAKIE"
     gene            39997..41691
                     /locus_tag="VHC05_000039"
     CDS             39997..41691
                     /locus_tag="VHC05_000039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HEQ5401394.1"
                     /translation="MTYNEVYQEWLHNNDLSDDIKADLAAIKDNEAEIQDRFYKTLEF
                     GTAGLRGKLGAGTNRMNTYMVGKAAQALANTIIDHGPEAVKKGIAVSYDVRYQSRTFA
                     ELTCSIMAANGIKAYLYKGIRPTPMCSYAIRALGCISGVMITASHNPQAYNGYKAYWQ
                     EGSQILDDIADQIAQHMAALTQYQEIKQMPFEKALDSGLVTYIDESIEEAYKKEVLGL
                     TINDTDIDKSVRVVYTPLNGVGNLPVRDVLRRRGFENVYVVPEQEMPDPDFTTVGYPN
                     PEVPKTFAYSEKLGKAVDADILIATDPDCDRVALEVKNAVGDYVFLNGNKIGALLSYY
                     IFSQRFDLGNLPANPVLVKSIVTGDLSRAIASHYGIETVETLTGFKNICGKANEYDVT
                     KQKNYLFGYEESIGFCYGTFVRDKDAVSASMMIVEMAAYYKKKGQNLLDVLQTIYATF
                     GYYNERQIALELEGIEGQKRIARIMEDFRQTPIASVAEMALDKTIDFIDGYQDFPKQN
                     CLKFYLDDGSWYALRPSGTEPKIKFYLYTIGQTQENSATKLDAIEAACRTKINQVN"
     gene            41899..42753
                     /locus_tag="VHC05_000040"
     CDS             41899..42753
                     /locus_tag="VHC05_000040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="HEQ5401395.1"
                     /translation="MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDP
                     ASQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPN
                     HINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKH
                     AVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQ
                     YIKEGAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQ
                     SALRSTHK"
     gene            42906..44246
                     /locus_tag="VHC05_000041"
     CDS             42906..44246
                     /locus_tag="VHC05_000041"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="HEQ5401396.1"
                     /translation="MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQY
                     FSLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDG
                     IGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRF
                     PGVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVV
                     QAIFESQLPVISSVGHETDTTLADFVADRRAATPTAAAELATPITKTDLMSWIVERQN
                     RSYQACLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSA
                     KENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMASQYDSQLARFEKAQDALLS
                     LDASRIIARGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI"
     gene            44224..44439
                     /locus_tag="VHC05_000042"
     CDS             44224..44439
                     /locus_tag="VHC05_000042"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="HEQ5401397.1"
                     /translation="MSKTKTFEENLQDLETIVNKLENGDVPLEEAISEFQKGMLLSKE
                     LQKTLQAAEKTLVKVMQADGTEVDMDD"
     gene            44439..45311
                     /locus_tag="VHC05_000043"
     CDS             44439..45311
                     /locus_tag="VHC05_000043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyprenyl synthetase family protein"
                     /protein_id="HEQ5401398.1"
                     /translation="MDKLARIDEAIRRYYKTTSNGVSEELIDAILYSVDSGGKRIRPL
                     ILLEMIEGFGVSLQNAHFDLAAALEMIHTGSLIHDDLPAMDNDDYRRGRLTNHKQFGE
                     ATAILAGDSLFLDPFGLIAQAELNSEVKVALIQELSLASGTFGMVGGQMLDMKGENQA
                     LSLPQLSLIHLNKTGKLLTFPFKAAALVTEQAITVRQQLEQAGMLIGHAFQIRDDILD
                     VTASFEDLGKTPKKDLFAEKATYPSLLGLEASYQLLTESLDQALTIFQTLESDVGFKP
                     QIITKLIEGLRLNA"
     gene            45304..46131
                     /locus_tag="VHC05_000044"
     CDS             45304..46131
                     /locus_tag="VHC05_000044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015017216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="HEQ5401399.1"
                     /translation="MPKERVDVLAYKQGLFETREQAKRGVMAGLVVSVINGQRYDKPG
                     DKIDDGTELKLKGEKLKYVSRGGLKLEKGLHVFGVSVANQIGIDIGASTGGFTDVMLQ
                     DGAKLVYAVDVGTNQLVWKLRQDPRVRSMEQYNFRYAQPEDFNEGQPVFASIDVSFIS
                     LSLILPALHNVLSDQGQVIALIKPQFEAGREQIGKKGIVKDKQIHEKVIQKVMDFASG
                     YGFTVKGLDFSPIQGGHGNIEFLAHLVKSQTPETLAPHLIQEVVAKAHKEFEKHEKK"
     gene            46118..46588
                     /locus_tag="VHC05_000045"
     CDS             46118..46588
                     /locus_tag="VHC05_000045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEQ5401400.1"
                     /translation="MKKSERLELIKKMVLTHPIETQHDLLRLLAEHGLELTQATISRD
                     MNEIGIVKIPSGSGRYIYGLSQDSGKKIVQGPRSIKSTILAVSDKTKGLEQHLYLKVV
                     PGNSKLIKRYLLADFSKAIFSLIADDDSLLLIAKSPSEADMIRQEILLWMQGIT"
     gene            46609..48270
                     /gene="recN"
                     /locus_tag="VHC05_000046"
     CDS             46609..48270
                     /gene="recN"
                     /locus_tag="VHC05_000046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecN"
                     /protein_id="HEQ5401401.1"
                     /translation="MLLEISIKNFAIIDEISLNFENGMTVLTGETGAGKSIIIDAMNM
                     MLGARASTEVIRRGANKAEIEGFFSVDATPELVACLESSGIAMEEELIIRRDIFANGR
                     SVSRINGQMVNLATLKQVGQFLVDIHGQHDQEELMRPQLHQQILDAFGDKAFEQLKEN
                     YQLIFDRYKSLRRQVIDKQKNEKEHKDRIDMLAFQIAEIEAAALSRGEDDRLNQERDR
                     LMNHKQIADTLTNAYVMLDNDDFSSLSNIRSSMNDLLSIEQFDSEYKGMSTSISEAYY
                     ILEEVSKQLSDTIDQLDFDGGRLQEIEFRLDTLNSLTRKYGGNVNDVLDYYDNIIKEY
                     QLLTGDDLSSGDLESELKALEKQLVAAATNLSERRHQLAEQLEAEIKAELKELYMEKA
                     DFKVHFTTSKFNRDGNESLEFYISTNPGEGFKPLVKVASGGELSRLMLAIKAAISRKE
                     DKTSIVFDEVDTGVSGRVAQAIAQKIYKIGRHGQVLAISHLPQVIAIADYQYFISKES
                     KEESTVSKVRLLTPEERVEEIASMIAGTDMTQAALTQARELLAKH"
     gene            48442..49374
                     /locus_tag="VHC05_000047"
     CDS             48442..49374
                     /locus_tag="VHC05_000047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEQ5401402.1"
                     /translation="MTSKKACLSSIIVLASLTCGNDTVSANHLSATGDKFDDCSTLVE
                     KDVAPKDELEMLAWSSSQTTDDADRDYEDFLDDDSFISQNETDKMFENLTDDRLLNEL
                     DESDEEDEEDTIEPEQNVIMPSDDELFDLTDAVETRLTVSSAPHLEAELPKPHLRSLS
                     DTALRSGEIRGHLDNKLDALSVTATKLALTMAQKFDLTTHVYSIGESFSEVLAAHYED
                     RKAESAFSKKKRFHLPIATPDVVIEELRRLVSSIGSSKEDVSVPYNRKLGMAVAKRKI
                     ALPQTGEGFSYYPVLLGLMILGLTPIMIPKKINN"
     gene            49590..50441
                     /locus_tag="VHC05_000048"
     CDS             49590..50441
                     /locus_tag="VHC05_000048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEQ5401403.1"
                     /translation="MEKYMGTIKIVTDSSITIEPELIKALDITVVPLSVMIDSKLYSD
                     NDLKEEGHFLSLMKASKSLPKTSQPPVGLFAETYENLVKKGVTDIVAIHLSPALSGTI
                     EASRQGAEIAEAPVTVLDSGFTDQAMKFQVVEAAKMAKAGASLNEILAAVQAIKSKTE
                     LYIGVSTLENLVKGGRIGRVTGVLSSLLNVKVVMALKNDELKTLVKGRGNKTFTKWLD
                     SYLAKNSHRPIAEIAISYAGEASLALTLKERIAAYYNHSISVLETGSIIQTHTGEGAF
                     AVMVRYE"
     gene            50434..51276
                     /locus_tag="VHC05_000049"
     CDS             50434..51276
                     /locus_tag="VHC05_000049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="HEQ5401404.1"
                     /translation="MNNRHLFSGIFFFVISLCLAFLLLNIIIPKSNSRLKKSDFLKKE
                     QVAIQYVAIGDSLTEGVGDLTHQGGFVPLLTNDLSEYFKANVNHQNYGVSGDTSQQIL
                     DRMIKQKQIQLSLKKADIMTLTVGGNDVMAVIRKNLADLQVSSFRKPARQYQKRLRQI
                     IELARKDNKDLPIFILGIYNPFYLNFPELTDMQKVIDDWNTKTKEVVGEYDRVYFVPI
                     NDLLYKGINGQEGIVHSSGDQTTIVNDALFTGDHFHPNNTGYQIMSNAVMEKIKKHEK
                     KIKP"
     gene            51254..51841
                     /locus_tag="VHC05_000050"
     CDS             51254..51841
                     /locus_tag="VHC05_000050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YpmS family protein"
                     /protein_id="HEQ5401405.1"
                     /translation="MKKKSNLNWWKWSFLCLLAFNTAFLMVIASRLIQVREPESELIA
                     KKPVKNIKIGTFVTTREQLNETVASYLKDYQTKKMSYKFYATSSSILFEGTYQLLGYE
                     VPLYIYFQPHRLENGAVQLQVISFSVGTLPLPEKDVLQYLKSSYKLPSFVKVMPNQSA
                     IVVNLQDIQNDAKVYLKAKKIDLFNDEISFNIYKK"
     gene            51940..52215
                     /locus_tag="VHC05_000051"
     CDS             51940..52215
                     /locus_tag="VHC05_000051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HEQ5401406.1"
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVDAVFSTIEAFLAEGEKVQ
                     LIGFGNFEVRERAARKGRNPQTGAEIEIAASKVPAFKAGKALKDAVK"
     gene            complement(52304..53446)
                     /locus_tag="VHC05_000052"
     CDS             complement(52304..53446)
                     /locus_tag="VHC05_000052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEQ5401407.1"
                     /translation="MWIEETDNGKFKFRENYKDPYTGTWKPVSVTMEKDNSRAYKAAR
                     KILEQKITEKIAQLKASELLFTELLDEWWAFYKKELKRSSVASLRGNIEEIRETFGIG
                     VKVVNIDPKYVQNYLDNLDCSRNKKERNKSMLNLAFDYAVGLDIIQDNPARRAKLPRV
                     KKTLEDWKKAEEKYLEEDEIKPLLKELYRRPSTYRLGLLAEFISLNGCRIGEAVSIEP
                     CNYESKSRILQLHGTFDHTEGYRNGEKTAPKTLASYRETIMTSRELEILQELEFMNEL
                     EKNTNHRYRDMGYLFTTKNGVPIQTNSFNLALKKANERLEDPITKKLTSHIFRHTLIS
                     RLAENNVPLKSIMERVGHADAKTTAQIYTHVTKKMKSSVADIMENY"
     gene            complement(53570..54088)
                     /locus_tag="VHC05_000053"
     CDS             complement(53570..54088)
                     /locus_tag="VHC05_000053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIRAN domain-containing protein"
                     /protein_id="HEQ5401408.1"
                     /translation="MAKVIFQDNFLLMGTNYHEKEANKVMAEIGKKSPYWDKDKDFIS
                     DYIKSNFKDIYKYYRVSTKDVEVVREPLNRHDPNAIKVMVNKTFVGYFPADLAKRLTP
                     YVKKSSHYQMEATLTGRGGQYKTLKNDLKTVVTKKKDITYKLRLTILKVDRVSKSKNA
                     GLLESIASWFLN"
     gene            54241..54586
                     /locus_tag="VHC05_000054"
                     /pseudo
     CDS             54241..54586
                     /locus_tag="VHC05_000054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988361.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecT"
     gene            54864..56357
                     /locus_tag="VHC05_000055"
     CDS             54864..56357
                     /locus_tag="VHC05_000055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401409.1"
                     /translation="MVDDVLPKLLKSVRQDFEKYFGESDVVTKAFAELQAKKVTYKTV
                     NEFAIEVGRLLSLALTGSVSSDKLPDGKMYYNIAKRLLDETMGRNYKLISGYAGDVQR
                     ILNENAQIGLKVQRPPLNRDKINGMVNRLDSENTFDDVKWLFGEPIVNFSQSIVDDTI
                     KANADLQYKTGMTPQVVRTESGNCCEWCREVVGTYSYPKVPKDVWRRHQRCRCTLDYD
                     PKNGKVQSAWSKIWRKKEKTQESIERVEKFKESALVESIKNDIAKLDMTKVGPSDIID
                     IGKRINYHFRVSEHIGDKEKLKEIFSNFREIGGEIPKNTWAKGSSKLVKDQLQEAFQN
                     YPTEWAAVPDGIGKKLKAIKRKRGYFDGYDEDLVIATNGTRKTTPYHEIGHMIELVNP
                     DLVRLEKAWVDKRTANEAEVRLKDIFPSSNYGIGEVTKKDDFISPYIGKYYSDAAEVF
                     TMGLQGIFVPEERFAKSFDKKTWKYDYKTINDDPEFLNFIIGLFVKV"
     gene            56363..56587
                     /locus_tag="VHC05_000056"
     CDS             56363..56587
                     /locus_tag="VHC05_000056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401410.1"
                     /translation="MEPKLHRQLRQKYDDAEKQYLEKFGEDSLDRVFFWEPDVYFDEW
                     KKVLPDATLELNKAINSGVAIDPDPENAIY"
     gene            56639..56905
                     /locus_tag="VHC05_000057"
     CDS             56639..56905
                     /locus_tag="VHC05_000057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401411.1"
                     /translation="MNKRIKKKRKLETAVVLLIAENARQAEAIKNQNKQIMELKSIVQ
                     RNALATNEELATVKAATLDNQSVIKAIGDTVDYIKKNYKRKWGK"
     gene            56907..57143
                     /locus_tag="VHC05_000058"
                     /pseudo
     CDS             56907..57143
                     /locus_tag="VHC05_000058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106704.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            57225..58640
                     /locus_tag="VHC05_000059"
     CDS             57225..58640
                     /locus_tag="VHC05_000059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="terminase"
                     /protein_id="HEQ5401412.1"
                     /translation="MVTKTKTKLGNQRPTQSVNLHFAKSLAHEAINYYKKTGLSCYPW
                     QENMLIPIMAVDEDGLWVHQKYGYAIPRRNGKTEVVYIVELWALHKGLKILHTAHRIS
                     TSHASFEKVKKYLEMSGYVDGEDFISNKAKGQERIEFKASGAVIQFRTRTSNGGLGEG
                     FDLLIIDEAQEYTSEQESALKYTVTDSDNPMTIMCGTPPTMVSTGTVFEAYRKDCLKG
                     NKRYSGWAEWSVPEMVKINDVSSWYISNPSMGFHLNERKIEAELGEDEIDHNIQRLGY
                     WPSFNQKSVISEKEWAKLKVEQVPELKSKLFVGIKFGQDGNNVSLSIAARTSENKVFV
                     ETIDCLSVRNGTQWIINFLKSADIAKVVIDGASGQELLAQEMKDQGLKKPELPKVAEI
                     ITANMMWEQGIMQETICHSDQPSLTAVVTNCEKRQIGSNGGFGYKSLYDDRDISLMDS
                     ALLAHWICYTTKPKRKQRTSC"
     gene            58720..59181
                     /locus_tag="VHC05_000060"
     CDS             58720..59181
                     /locus_tag="VHC05_000060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4355 domain-containing protein"
                     /protein_id="HEQ5401413.1"
                     /translation="MSEFKVIETQEELDTIVKARIAREREKYQDYDQLKTRVEELETE
                     NSSLQTALNDAKSNTDSYTEEISTLKNQIADYETANLRTKVALQYGLPIDLADRLQGD
                     DEDGLKVDAERLASFIKPSQPQPPAKSNEPNIDSNADANYRALVQGLSTED"
     gene            59206..60117
                     /locus_tag="VHC05_000061"
     CDS             59206..60117
                     /locus_tag="VHC05_000061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage major capsid protein"
                     /protein_id="HEQ5401414.1"
                     /translation="MGTETSKASLFDKHLVSDLINKVKGHSSLAKLSSQKPIPFNGSK
                     EFTFTLDSDIDVVAENGKKTHGGLSLEPVTIVPIKVEYGARLSDEFLYATEEEKIDIL
                     KAFNEGFAKKLARGIDLMAMHGINPRTKKASDVIGTNHFDSKVTQVVKFTESEDADAN
                     IEAAVNLIQGAEGVVTGLAMDTEFSTALAKVTNGEMGPKMYPELAWGADPDSINGLKS
                     SVNTTVGAGADEAESKDLVIIGDFESMFKWGYAKQIPMEIIKYGDPDNSGKDLKGYNQ
                     IYLRAEAYIGWGILDAKSFARVTKGEV"
     gene            60117..60317
                     /locus_tag="VHC05_000062"
     CDS             60117..60317
                     /locus_tag="VHC05_000062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401415.1"
                     /translation="MLYVNSKTGASFYSSVPVCGGDWTLVEQQTGEKAKTVAEIKRQL
                     DAAGIKYSSKAKKPELEALLPG"
     gene            60327..60749
                     /locus_tag="VHC05_000063"
     CDS             60327..60749
                     /locus_tag="VHC05_000063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage Gp19/Gp15/Gp42 family protein"
                     /protein_id="HEQ5401416.1"
                     /translation="MGNFATTDDVILLWRPLSVDELKRANALLKVVSDTLRMEADKVG
                     KDLDKTMVDKPYFVNVIKSVTVDIVARTLMTSTQGEPMSQESQSALGYTWSGTYLVPG
                     GGLFIKDNELKRLGLKKQRYGGIELYGEIKRDNDYFDR"
     gene            60709..61046
                     /locus_tag="VHC05_000064"
                     /pseudo
     CDS             60709..61046
                     /locus_tag="VHC05_000064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767029.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            61039..61275
                     /locus_tag="VHC05_000065"
     CDS             61039..61275
                     /locus_tag="VHC05_000065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401417.1"
                     /translation="MSKFKFKLNKAGVAELMKSSEMQQVLTTKATAIRERCGDGYAQD
                     IHVGKNRANAMVSAKTIKAKKDNSKNNTLLKAVR"
     gene            61276..61611
                     /locus_tag="VHC05_000066"
     CDS             61276..61611
                     /locus_tag="VHC05_000066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401418.1"
                     /translation="MIEVIIKKYLDEHLDVPSFFEHQKDEPARFIILEKTSGVKQNHL
                     LSSTFAFQSYAESLYEAALLNDKVKQVIEQLDVLPQVSGVHLNADYNFTDTATKRYRY
                     QAVFDINHY"
     gene            61623..62201
                     /locus_tag="VHC05_000067"
     CDS             61623..62201
                     /locus_tag="VHC05_000067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEQ5401419.1"
                     /translation="MNKNDTKNVTSAKPKTGGAIYSAPLGAKLPENATDDLDDGFKNL
                     GYVSEDGVTNEDTRSSENIKAWGGDIVGAVQTEKEDTFTYKLIESLNVEVLKEVYGAK
                     NVTGDLDAGIHIKSNSKELEAHVIVVDMIMNGGILKRIVLPNAKVDEVGEIVYVDGGV
                     VGYETTLKCFPDENGDTHHEYIVKPKAQNLEM"
     gene            62212..62394
                     /locus_tag="VHC05_000068"
                     /pseudo
     CDS             62212..62394
                     /locus_tag="VHC05_000068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922455.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            62414..64771
                     /locus_tag="VHC05_000069"
     CDS             62414..64771
                     /locus_tag="VHC05_000069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401420.1"
                     /translation="MATELGQAYVQIMPSARGISGAISKQLDPEARSAGLSAGSLIGG
                     NLVKMIGGAIAAAGIGKMISSALSAGADLQQSFGGIDTLYKGAETAVKGFAKEAYKAG
                     ISANTYAEQAVSMGASLKQSLGGDAVAAAKAANMAIMDMADNSAKMGTDITSIQMAYQ
                     GFAKQNYTMLDNLRLGYGGTKEEMKRLLSDAEKLPAAMGKKFDLSNYADVVEAIHLVQ
                     DNMGIAGVAAEEAKTTFSGSLAAMKSSFTNVLAGLSLGDDIRPALRGLAETTSNFLFG
                     NFIPMVANIFKGLPSAIGTFIGAATPIIASQFKGLMSSLGISIDLSPITAKFAQIGQN
                     LQPVFDGLKTAFGQLPSFFTSIGDAVAPVIDTIISGLARLDFSGFEALISAILPAIQT
                     GFQTFMSIVGPAISQLVNSFVNLWNACQPLVTILSSALMPAFQILGAFLGGVLQGILG
                     SISFAFDALKVVIEFLTPIIDWLVQGFNAISPALQTVAQWVGNVIGIFTSLGASGQGL
                     SSMLSSAWGNIQTVVSTAKNMITLAIDGIKLVFSNLGNAGNILKGLLSAAWSAMQNAV
                     VIAKGIINSAISAIKTAFSSFGNLVSSVSGTIKSVIGSLKNAFYSLASIDLVGAGRAI
                     MQGFLNGLKSMWGAITGFVGGIADWIRKHKGPISYDRVLLKPAGKVIMQGFNNSLMDG
                     FKEVKSNVSGMADDLAGTITGKSLSLGIDAKPSVTADDLLSSNISTKTTVGSATSDLS
                     LFFVKVLALLQDILDKNTDVYLDKEKVSAILYEEFAKIMAREGIA"
     gene            64768..65463
                     /locus_tag="VHC05_000070"
     CDS             64768..65463
                     /locus_tag="VHC05_000070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401421.1"
                     /translation="MIPKVIIDGFDTSTIPNCVLTGYDVGDVLSPHFVENEVYGMNGT
                     SRGLESYNESKPTLTWHLSTFDDAVNLVNHLDGLGKIIEFWHIPKSFYYYDCLSVKIN
                     AVTMNSWRVTLKLALYPFRYAKGISDVTIAGNGSINNPGNVFSEPKIIVEGTGKGTLT
                     IDKQVMELNLSGKATIECKHGQQCVYDGEGNVKNSIRIRGRFFEIQPGTQGIAVSGGI
                     ARLTISPRWRYKV"
     gene            65445..67421
                     /locus_tag="VHC05_000071"
     CDS             65445..67421
                     /locus_tag="VHC05_000071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEQ5401422.1"
                     /translation="MEVQGLISIKDDNTPLVAAFEDEITQEANSDYKLSFKYPAKHEY
                     RPLIKKGIILEADDLHGTQLFRVFEITKRHGYINVYGNQVADDLNGYAIDSISVDRVQ
                     GMTVMSELAGNIKRKHPFSFFSDIDGRHTFNQSDVSVMDALANGKHSIMGQWGGELVR
                     DKYQVNLLKKAGKDIETLFMYKKNLKSYEETDTIKGLVSILHLVAEVEEEHEVETRET
                     SDGNIGHSESPKKKTIRVSVESKLKDTHPIIVEKTIKVQDQDVKTEEDLLAYGKKYFE
                     KTLCDIPGNSLKIDVTNNYEGAVRLFDTAIVFHELYDRDLRMQITGYRFAPMANRLKS
                     IIFGEIKTNLAKQISNQIDNKVAESTAQHDAVFEAKLQKQIDNANRIFDTKEAKLREE
                     IEDGIKKAEANAEVKVAEVNAKVLEAEELAKAVDERLKKFLSDADTKEQDFDKKLEEF
                     RTSLKDLEVDEKQIDDALAKAGFSKDSLADIKAKLEDTSETATVTANIVGSTGGTFYN
                     RNRLDGDTDKVITFEQGYIDIAHNGEGFEEGKTYTISFEATCELLRKVGITVTQANMK
                     GARLVLTPKNPKLVVESFGLTKDTETINVYPFSYTVLVTSDWYKSKQIDLNASDTQEL
                     ALEMDYKDVVDGKDATITGAWSDSPQIILYGGKK"
     gene            67418..68533
                     /gene="hylP"
                     /locus_tag="VHC05_000072"
     CDS             67418..68533
                     /gene="hylP"
                     /locus_tag="VHC05_000072"
                     /EC_number="3.2.1.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_115223326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hyaluronoglucosaminidase"
                     /protein_id="HEQ5401423.1"
                     /translation="MTETIPLRVQFKRMKAAEWASSDVVLLEGEIGFETDTGFAKFGD
                     GQNTFSKLKYLTGPKGPKGDTGIQGKTGGTGPRGPAGKPGTTDYDQLQNKPDLGAFAQ
                     KEETNSKITKLESSKADKSAVYSKAESKIELDKKLSLTGGIVTGQLQFKPNKSGIKPS
                     SSVGGAINIDMSKSEGAAMVMYTNKDTTDGPLMILRSDKDTFDQSAQFVDYSGKTNAV
                     NIVMRQPSAPNFSSALNITSANEGGSAMQIRGVEKALGTLKITHENPNVEAKYDENAA
                     ALSIDIVKKQKGGKGTAAQGIYINSTSGTAGKMLRIRNKNEDKFYVGPDGGFHSGANS
                     TVAGNLTVNYPTSEKHAATKKYVDEKIAELKKLILKK"
     gene            68548..70329
                     /locus_tag="VHC05_000073"
     CDS             68548..70329
                     /locus_tag="VHC05_000073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401424.1"
                     /translation="MSRDPTYTINEHDLSFADGRFYVTFKADKSSETVRLNSSCLGNT
                     IIKKLQVEDDNTMHDFVKPKVTTQQAFGLAQQVKELDLQLKDPKSDLWGKIKFNNKAM
                     LVEYANKEMSSAIAQSAEQILLQVKSIDDERYSKFEQTLNGIKQTVKSESVESARTQL
                     ASMFDSRISGLDGKYSRLSQTIDSLSSRLDDGVGNYSTLSQKVSGIDLRVSNAANDVS
                     RLSQTAQGLQSQITNANQNYSSLSQTVGGLQTTVHDNQSNATSRINQLSDLISTKVTK
                     GDVETTIAQSYDKIAFAIRDKLPASKMTGSEIISAINLDRSGVKITGKNITLDGNSYI
                     SNAVIKDAHIANMDAGKINTGYLNASRIAAEAITGDKIKMDYAFFNKLTANEGYFRTL
                     FAKNIFTTSVQAVTTSASKITGGVLSATNGASRWDLNSANIDFNRDATINFNSKNNAL
                     VRKSGTHTAFVHFSNATPKGYRGSALYASIGITSSGDGIDSASSGRFCGVRFFRYAEG
                     LQHTAKVDQAEIYGDDIVFSDDFNIDRGFKMRPSLMPKMVDLNKMYQAILALGRCWLH
                     ANNTAWSWNFDTRSAIIAEYNAHINNL"
     gene            70338..70766
                     /locus_tag="VHC05_000074"
     CDS             70338..70766
                     /locus_tag="VHC05_000074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1617 family protein"
                     /protein_id="HEQ5401425.1"
                     /translation="MDLTLKNKDLNTLYSVLDKIKITNMRANRGRAKLLAKVVDKFKE
                     YAKDEGDLIDLYAQKDKDGKFVIDEHKNIKLADPAKLDEFNGLLNELADEEIVIKGGE
                     YSKRFIDFLEYLAESEDEFTAQEIIIVDSILEQYEGSKGE"
     gene            70769..71401
                     /locus_tag="VHC05_000075"
     CDS             70769..71401
                     /locus_tag="VHC05_000075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401426.1"
                     /translation="MKTLTLSGKPYPIHEGGKVVKTEVRLIGDNGLFIPIELIGDQTA
                     KGADDLIKEGLDAFVREYVTKYAVAESVQKVEELSLAQKEIEQNAEQAKVTAEAAEKQ
                     AKSLELVIAKSQKMANLQAIHLLTSGSKVEPDIYKGLLELIEPAKQGEYQAYDVFTVV
                     DESHEEQAGEGNLVFVHVNEPFTYDKQTLKELEEEDKVTVIKYADLVKQD"
     gene            71413..71685
                     /locus_tag="VHC05_000076"
     CDS             71413..71685
                     /locus_tag="VHC05_000076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401427.1"
                     /translation="MATELIFGLGGFILAIVTTYNIFNAKSIKHATDITLLQSEVEHL
                     KIVTRQNARRLEEHDEQNKTLITMTEQIKNLNREVRELKDIMRGEA"
     gene            71682..71909
                     /locus_tag="VHC05_000077"
     CDS             71682..71909
                     /locus_tag="VHC05_000077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016480475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin"
                     /protein_id="HEQ5401428.1"
                     /translation="MINLKLRLQNKVTLMAILGAIFLLAQQLGIKLPSNIADIANTAV
                     TLLVLLGVVTDPTTKGLSDSEQALTYHEPKQ"
     gene            72028..73245
                     /locus_tag="VHC05_000078"
     CDS             72028..73245
                     /locus_tag="VHC05_000078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HEQ5401429.1"
                     /translation="MVVDTEKAIAWMGLKKGRVSYSMDCRNGPDSYDCSSAICSALIY
                     AGASNPGWLLNTEYMHDWLVQNGFELIADNEDWDSQRADIAIWGFRGQSAGAGGHVVM
                     FIDADNIIHCNYANNNITIDNYNQTAAASGWMYSYVYRYTGAKAQPATNKSIDELVQE
                     VLSGKHGSGEQRKISLGTNYDAVQAKVNEMLKQPQVAEQSPAVKQDGDLLFNGAVLKK
                     TVLDKILAKCKEHDILPSYAITVLHFEGLWGQSAVGRTDNNWGGMTWTGQGNRPSGIT
                     VTQGTERPAVEGGHYMHYASVDDFLTDWFYLLRADGSYRVSGAKTFSEAVKGMFKVGG
                     ATYDYAASGFDSYIVGMAGRLKAIEQENGSLAKYDQQADIDVGQSDKIDVVIDSLEIT
                     INGVTYTATKKPI"
     gene            73381..74505
                     /locus_tag="VHC05_000079"
     CDS             73381..74505
                     /locus_tag="VHC05_000079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HEQ5401430.1"
                     /translation="MALQGIKKLPVLLEDKQALSLYKKLAIVNKVLGKLDAVLESSII
                     NSSILSLLSYNESVQSTRIEGTQVTFHEIMETAKVGAKNWQQREVFNYKKAIDFGFHK
                     IKKGDVITTRLIKDLHRLLMSDEARGTTSNGGEFRKIQNFIGPDKDIENASYIPIPAN
                     EIGAFMTNLEFFINGEYHSSLECGRTQESINFNSDILLRIAVAHAQFESIHPFLDGNG
                     RLGRILIALMSVQEGLLKHPIFFVSEELEKERIRYYNALNATRGENPDWNLWLNLFLN
                     ASEQMAKNILKKIRNADEHAKKGLSVCVTQTQKTVWLATFSFPVSTAKQLAEATEFHP
                     ATVKKALDFLVGEGLLDKDNSVKRNVPYYNYDLIRAIQNY"
BASE COUNT        23971 a        12833 c        15922 g        21937 t
ORIGIN      
        1 agtataaatt tttacactaa gatgtaaaaa acatacaagt aaacgaatac aaatctataa
       61 aaataaaaac aacgctcaaa aaatgtaagc gattactcaa aatgactgtg agaaataccc
      121 tatttttatc ttttttaagg agtacactag gaatataagc aagagttaag aatcttgacg
      181 gtgaattcac aaaaaccaat tagaaagagg taattcttat gactgctcaa acaccaattc
      241 atgtttattc tgaaattgga aaattaaaaa aagtgttgct ccacagacct ggtaaagaaa
      301 ttgaaaatct tatgccagac tacttggaac gcttgttgtt tgatgacatt ccattcttag
      361 aggatgccca aaaagaacat gatgcttttg cccaagcttt gcgtgacgaa ggtattgaag
      421 tcttgtacct tgagacctta gctgcagaat ctcttgtcac tccagaaatt cgcgaagctt
      481 tcatcgatga atacctaagt gaagctaata tccgtggaag agctactaaa aaagccattc
      541 gtgaattgtt gatggctatc gaagacaatc aagaattgat tgaaaaaacc atggcaggag
      601 ttcaaaaatc tgaacttcca gagatcccag catctgaaaa aggcttgact gacttggttg
      661 aatccaatta cccatttgcc atcgacccaa tgccaaacct ttatttcaca cgggacccat
      721 tcgcaactat cggtacaggt gtttctctta accacatgtt ctcagaaaca cgtaaccgtg
      781 aaacccttta tggtaaatac attttcactc atcacccaat ttatgggggt ggcaaagtgc
      841 ctatggttta tgaccgtaat gaaaccactc gcattgaagg tggggacgaa cttgttcttt
      901 caaaagatgt gcttgcggtt ggtatttctc aacgtacaga tgctgcttct attgaaaaat
      961 tgttggttaa catctttaaa caaaaccttg gcttcaagaa agtattggcc tttgaatttg
     1021 caaataaccg taaatttatg cacttagaca ctgtctttac catggttgac tatgacaaat
     1081 ttaccattca cccagaaatt gaaggcgacc ttcgtgttta ctctgtcact tacgataatg
     1141 aagaacttca tatcgttgaa gaaaaaggtg atttagcaga acttcttgct gctaaccttg
     1201 gtgttgaaaa agttgacctt atccgttgtg gtggtgacaa cttagtagca gcaggtcgtg
     1261 aacaatggaa cgatggttct aacaccctta ctatcgcacc aggtgtggtt gtggtttata
     1321 accgtaacac cattaccaat gctattcttg aatctaaagg cttgaaattg atcaagattc
     1381 acggaagtga attggttcgc ggtcgtggtg gacctcgttg tatgtcaatg ccatttgaac
     1441 gtgaagatat ttaataagct atggtaaagg tggttatagg tcagaagcct ttttaaaggg
     1501 cagctagtgt ttatcttcgc ttctgtgtct ttgtccttca atgaaatttt gtcatgacag
     1561 ataaatttga tgccaatgac gaaacaagaa cggtttatgc agtcgtttat gacaatgacc
     1621 agcccgtttc aacaggacaa tttttagctg aaacgaaaat agaagcacga ttgacacgca
     1681 ttgtaacctt agcggattat tgtggttgcg gttatggtgc caaagtcact gaagcgctag
     1741 aaacttatac cagacgagaa ggcttttacc aactaaccat tcacagtgaa ctgacagcac
     1801 aaacctttta tgaaaaccta ggttatcaga cctatggttc caagtattta gaagatggtg
     1861 agtattgtca atcccttgtt aaaaccattg cttaatggga gaagaatatg gacatagcaa
     1921 tgctagttgc gattgttggt ggtctattag gctgctatct ctatctcaca aaaaataatg
     1981 aacccaaaga ttaagttaat actcgaagga gacaatagat gacacaagta tttcaaggac
     2041 gtagcttcct agcagaaaaa gattttacac gcgctgaatt agaatacctt attgattttt
     2101 cagctcattt gaaagatttg aaaaaacgtg gtgtgcctca tcactactta gaaggtaaaa
     2161 acattgccct cttgtttgaa aaaacatcaa ctcgtacgcg tgcagctttt acaacagcag
     2221 ccattgacct aggtgctcac ccagaatacc ttggtgccaa tgacatccaa cttggtaaaa
     2281 aagaatcaac tgaagacact gccaaagtat tgggtcgtat gtttgatggg attgaattcc
     2341 gtggctttag ccaacgcatg gttgaagaat tggcagaatt ctcaggtgtg ccagtttgga
     2401 atggtttgac tgatgaatgg cacccaaccc aaatgcttgc tgactattta acagtgaaag
     2461 aaaactttgg caaacttgaa ggccttaccc ttgtttactg tggtgacggg cgtaataacg
     2521 ttgccaattc ccttcttgtg actggtgcta tccttggtgt taatgttcat atcttctcac
     2581 caaaagaact tttcccagaa gaagagattg tgacattggc tgaaggctat gctaaagaaa
     2641 gtggcgctcg tatccttatc acagaagatg ctgacgaagc tgttaaaggc gcagacgtgc
     2701 tttacacaga tgtttgggta tcaatgggtg aagaagacaa attcaaagaa cgtgttgaat
     2761 tgcttcaacc atatcaagtc aacatggacc ttgttcaaaa agcaggaaat gacaagctta
     2821 tcttcttgca ctgcttgcca gctttccatg acacaaatac cgtttatggt aaagacgttg
     2881 ctgaaaaatt cggcgtgaaa gaaatggaag tcactgatga agtcttccgc agcaaatacg
     2941 ctcgtcattt tgaccaagct gaaaaccgca tgcacactat caaagcggtt atggcagcaa
     3001 cccttggtaa cctctttatt ccaaaagtgt aataaggact ggtactcctt aactcatttc
     3061 acatatcaat gtgacccctt taatttaaca atttaactac ttaaaaacgt actttaacta
     3121 catgacaagt cgttctggtt ttcgcgtcct tgaccggaac tagaacggct tatttttatg
     3181 aaaaggtaag aggtaatcat tatgacagaa gaaaaaaaac ggggttttag aattccttct
     3241 tcttacaccg ttctttttat cattatagcc atcatggcag tgttaacttg gtttattcca
     3301 gctggcgcct acgaaaccgc taagggcggt ggtgttattt caggaaccta caaaacagta
     3361 gcatccaatc ctcaaggatt ttttgacatc ttgatggctc ccgttcgagg catgttaggt
     3421 gttgaaggca ctgatggtgc tattcaagtg tctttcttta tcttaatggt tgggggcttt
     3481 ttaggagttg tcaacaaaac aggtgctctt gacacaggga ttgcgtcagt ggttcgtaaa
     3541 aacaaaggta gagaaaaaat gctgattgct attttaatcc ctttgtttgc tctaggtgga
     3601 acgacctatg gtatggggga agaaaccatg gccttttacc cacttttaat tcctgttatg
     3661 attgcggttg gttttgacag tattgttgct gtagccatta ttttgattgg ttctcaaatt
     3721 gggtgtctag cctccactat taacccattt gcaactggtg tagcagctga tgctgctggt
     3781 gtcagcattg cagatggaat gatttggcgt gttatccaat gggttattct tgtcggcatg
     3841 tctatttggt ttgtttacaa ttacgctagt aagattgaag aagacccaag taaatcattg
     3901 gttgcagaca aggaagaaga gcataaggaa ctcttccagt tgcaaaattc tggagaagac
     3961 ttaaacaagc gccaacgaaa cgttttgacc atttttactt tgacctttgt cattatgatt
     4021 cttagtttga ttccgtggga agattttggc atcaaattct ttactaatat caatacttgg
     4081 ttaaccacaa tgcctatctt agggggagtt attgggaaaa ccatgggagc atttggtact
     4141 tggtatttcc cagaaatcac catgctcttt atcatgatgg gtgtcttagt tgctattgtg
     4201 tatcgtatga gtgaagaaga cttttttagc tcttttttga ctggtgcagg tgaattttta
     4261 ggtgttgcca tgatctgtgc tattgcacgc ggtattcaag ttatcatgaa tggtggtatg
     4321 attacagcca ctatcttaca cttaggtgaa acaagtcttt ctggtttatc ttctcaagtt
     4381 tttgtgatat tagcttatat tttctacctc ccaatgtcct tcttgattcc atcaacatca
     4441 ggacttgctg gggctacaat gggaattatg gcaccgcttg gacaattctc aaatgtccct
     4501 gctcaccttg ttattacagc cttccagtca gcttctggaa tcttaaacat gatttctcca
     4561 acttcagcaa tcgttatggg agcacttgcg cttggtcgcg ttgaccttgg tacttggtgg
     4621 aaattcattg gtaaatttat tgtaatggtg atgcttgtaa gcgtgctatt acttgtagtt
     4681 gcaacattct tttaacagat aggaggttcc tatggaatcc tatatcacac ctaaacatca
     4741 agaggcctgt gtagctgcca ttaaacagat cgtttcttac ccttctgttt gtcatgaagg
     4801 agaaaatggc acaccttttg gacaggccat tcaagatgtt ctcgaagcaa ccttagactt
     4861 atgtcaaggt cttggttttc atacttatat tgatcctgaa ggttactatg gctatgctga
     4921 gttaggtgac caaaaagagg tcttggctat tctttgccat ttggacgttg ttccagaagg
     4981 agatcgtcag ttatggaaga cagatccttt tgactgtgtt gaggcagacg gctgtttatt
     5041 tggtcgaggc actcaagacg ataaagggcc tactatgatg gcgctatttg ccaccaaagc
     5101 cttgatagat gcaggcgtta cctttaataa acgcattcgt tttattttcg gaacagatga
     5161 agaaactttg tggcggtgta tgaatcgcta caatgatgta gaagaacagg ctacctttgg
     5221 gtttgctcct gattcaagtt tccctttaac ctatgccgaa aaaggcctac ttcaggcaaa
     5281 attagtgggg aaaggttgtg ataaactgtc acttgaaatc ggacaagcct acaatgttgt
     5341 tcctgcaaga gcttcttata aaggcaataa gcttgaggct ttacaaaaag aactagataa
     5401 gcttggcttt gagtacgtcg tcaaagaggg agaattaacg gtttatggtc tcgcccaaca
     5461 tgctaaagat gctcccgatg gcatcaacgc tatgattagg cttgccaagg ctttagtggt
     5521 ccttgaacct aacaaaaccc ttgattttct tgctaatgtc attgatgaag atggcagagc
     5581 acttaatatt tttggcagaa tcgaagatga accttcaggc aaattaagct ttaatgccgc
     5641 agggcttacc ttaaccaaag acaaggcaga aattcgccta gatattcgga ttccagtttt
     5701 ggcagataag gaaaaattag tccaacaatt aagccaaaaa gcacaagaat acggcctaac
     5761 ctatgaagaa tttgattatt tggccccatt atatgtgcca ttagacagtg aattggtaac
     5821 aaccttgtta tctgtctatc ggaaaaaaac aggtgatcaa agccctgccc aatcatcagg
     5881 aggggcaacc tttgctagaa caatgaagaa ttgtgttgcc tttggtgccc ttttccctga
     5941 tgctgttcaa acggaacacc aagaaaatga acatattgtt ttagcggatg cttaccgcgc
     6001 tatggatatt tatgcggaag ctatttaccg actaacgcga taacaagata tgaggagtaa
     6061 ttatgacgaa acaaaaaatc gtagtcgcac ttggaggaaa tgctattctt tcaacagatg
     6121 cgtcagcaaa agcacaacaa gaagccttga tgtccacatc aaaatcattg gttaaattaa
     6181 ttaaagaagg tcatgaagtc atcgtgaccc acggcaatgg cccacaagtt ggtaatctct
     6241 tattacaaca agcagcagca gattctgaaa agaatccggc tatgcctttg gatacttgtg
     6301 ttgccatgac agaaggtagc atcggttttt ggttagttaa tgcccttgat aatgaattgc
     6361 aagcccaagg tattcaaaaa gaagtggcag ctgttgtcac tcaagtgatc gtggatgcca
     6421 aagacccagc ttttgaaaac ccaacaaaac caattggtcc atttcttacc gaagaagatg
     6481 ccaaaaaaca aatgtcggag tctggtgcaa gtttcaaaga agatgcaggt cgtggctggc
     6541 gtaaggttgt gccatcacca aaaccagttg gtattaaaga agccaacgtc atcagaagtc
     6601 tggttgattc tggcgttgtt gtggttagtg ctggtggtgg cggtgtgccc gttgtggaag
     6661 atgcaactag caagaccctt acgggtgtgg aagccgttat tgacaaggac tttgctagcc
     6721 aaaccctttc agaattggtg gatgcagacc tctttatcgt tttgacaggg gttgacaatg
     6781 tttatgttaa cttcaacaaa cctgatcaaa caaaattgga agaagtaacg gtctctcaaa
     6841 tgaaagagta catcacacaa gaccaatttg caccaggtag tatgttacca aaagtggaag
     6901 ctgccattgc ttttgttgaa aacaaaccaa atgctaaagc cattatcaca tcgctcgaaa
     6961 atattgacaa tgtactatca gcaaacgctg gaacacaaat tatcgcaggg taatcaagag
     7021 gatttttagt tctgtttaaa agactcattt aatggtattt tctgaagagt acgactgaca
     7081 taaagagttt atactgtttt taaaggaaaa gagtgtgcca taataaaaaa caataatagt
     7141 attagaaaag gctaatttta ttgagaatta gccttttctt ttggctttga taggtgtata
     7201 ataaccatac tattttttat ttttcaaaat attagaataa acaaaagtag acaacgtata
     7261 aagagaactg ctaagtcgtt gagttcatta gtcccaaaaa gattaccaaa aaagaaggaa
     7321 gaactatgaa gaaaagtttt attcatcaac aagaggagat ttcctttgtt aaaaatacgt
     7381 tcactcagta tttaattgct aagttagatg ttgttgaagt gcaaggaccc attttaagtc
     7441 gggtcgggga tggtatgcaa gataatttgt ccggtactga aaatccagta tctgtcaatg
     7501 tcttgaaaat tcctaatgca acctttgaag ttgtgcattc attagcaaaa tggaaacgtc
     7561 acaccttagc ccgttttggg tttaatgaag gtgaaggcct tgttgttaat atgaaggctc
     7621 tccgacctga tgaggattca cttgaccaaa cccattctgt ctatgttgac caatgggact
     7681 gggaaaaagt catccctgat ggcaaacgta atctcgctta cctcaaagaa accgttgaaa
     7741 ccatttacaa ggtcattcgg ctaactgaat tagctgtaga agctcgttat gatattgagg
     7801 ctgttttacc taagaaaata accttcattc ataccgaaga attggtagcg aaataccctg
     7861 atttgacgcc caaagaacgt gaaaatgcca ttactaaaga atttggagca gtctttttaa
     7921 ttggtattgg cggggtttta cctgacggta aaccacacga tggccgcgct cctgactatg
     7981 atgactggac aacagaaact gaaaatggct atcatgggct taatggtgat attttggttt
     8041 ggaatgacca acttggttca gcctttgaat tatcctcaat ggggatccgt gtggatgaag
     8101 aggccctaaa acgtcaggtg gaaatgactg gtgaccaaga ccgcttagcc tttgattggc
     8161 acaaatcttt gttgaatgga cttttccctc taacgattgg tggaggaatc ggtcaatcac
     8221 gtatggtcat gtttttgttg cgtaaaaaac atattggaga agttcagacc tctgtttggc
     8281 cccaagaagt tcgtgatagc tacgataata ttttataagt aatcacatca ttttgctaag
     8341 ttttccactt gtataagaga ctttaaataa atgatcagaa atattgaaaa aagaaatcat
     8401 ttttaaggtt tagagctaga aatttgctat aataaatgtt atgagagttg tatcaggtga
     8461 atttggtggg cgtcctttaa agacgctcga tggaaagata acacgcccta cttcagacaa
     8521 agttagaggt gcgattttta atatgatagg accttacttt aatggtggtc gtgttttaga
     8581 tttgtttgca ggttcaggtg gattagccat tgaggctgtt tctcgtggga tgtctgctgc
     8641 agttttggtt gagaagaatc gtaaagcgca agctattatt caagacaata ttataatgac
     8701 taaagctgag aatcggttta ccttgttaaa aatggaagct gagcgagcta ttgattgctt
     8761 gactggtcga tttgacttag tctttttaga ccctccttat gccaaagaaa caattgtggc
     8821 aactattgaa gctttagcag ctaaaaactt attgagtgaa caggttatgg ttgtctgtga
     8881 gacagataaa acagtcttgt tgccaaaaga gattgcaacg ttaggtattt ggaaagaaaa
     8941 aatttatgga attagtaagg taacagttta tgttaactaa aataggactt tatacagggt
     9001 catttgatcc tgttacaaac ggtcatctcg atattgttaa acgggcaagt ggcctatttg
     9061 atcaaatata tgttgggatt tttgataatc ctaccaaaaa aagctatttt aaactagaag
     9121 ttcgtaaagc aatgcttact caagctctgg ctgattttac aaatgtaatt gtagtaactt
     9181 cgcacgaacg tttagctatt gatgtagcta aagaattacg agtaactcac ttgattagag
     9241 gtttgcgaaa tgcaactgac tttgagtatg aagaaaattt ggaatatttt aatcaccttt
     9301 tagctccaaa tattgagacc gtctatttga tatcaagaaa taaatggcag gcccttagct
     9361 ctagtcgtgt gagagagcta attcattttc agtcttcctt agaaggtttg gttcctcagt
     9421 cagttattgc tcaagtggag aaaatgaatg aaaagactta aaaaaatcaa atggtggtta
     9481 gtgggtctgc tagctttaat ctctttgttg ctagcgttat tttttccgct accttattat
     9541 attgaaatgc ctggaggcgc ttacgatatt cggactgtct tacaagtcaa tggcaaagaa
     9601 gacaaacgaa aaggagctta ccagtttgtt gcagtgggca ttagtcgtgc cagcctcgct
     9661 cagctattat atgcttggct gacaccgttt actgaaatta gtacagcaga agatacaaca
     9721 ggcggataca gcgatgctga tttccttcga attaatcaat tttacatgga aacatcacaa
     9781 aatgcagcta tttatcaagc tttatcctta gctggaaaac cagttacatt agattataaa
     9841 ggcgtatatg ttttagacgt aaacaacgaa tctactttta aaggaacgtt acacttagca
     9901 gatactgtaa caggtgtaaa tggtaaacag tttactagtt cagcagaact tattgactat
     9961 gtttctcacc taaaactagg ggatgaagtt acgattcagt ttacgagtga taataagcct
    10021 aaaaaaggag ttggccgtat tatcaaactg aaaaatggga aaaatgggat tggcattgcc
    10081 ttgactgatc atacaagtgt caattcagaa gacacagtga tctttagtac taaaggagta
    10141 ggaggaccta gtgctggtct aatgtttact cttgatatat atgatcaaat aactaaagaa
    10201 gatttacgca agggccgtac aattgcaggt acaggaacta ttggcaagga tggcgaagta
    10261 ggagatattg gtggtgcagg tcttaaagta gttgcagcag ctgaagctgg tgcagatata
    10321 ttttttgttc cgaataatcc tgttgataag gaaattaaaa aagttaatcc aaatgctata
    10381 agtaattacg aagaagccaa acgggcagcc aaacgactaa agaccaaaat gaagattgtt
    10441 cctgttacga ctgttcaaga ggcactggtt tatcttcgca aataaaataa ctatgaatgt
    10501 attatattca attatattca cgctattaac tcataaaaaa cggttgaacc agatagacag
    10561 atccttgacc agtcttttgg gttcaatcat tttttacata aaacatatct aacttgacag
    10621 cgtaaaaaag atgttataaa agtctagtgg taaaaaggca atagagaatt gagtaaactt
    10681 tagtcgatta tctggaaata gagcatacta aaaacaccta gtgaaaattg atttttttca
    10741 ctagctcatc caagaacttg cgcagataat catgagtcca ttccatgact ctattattct
    10801 ggaaagcctt gcaatagaca agctaacgtt ataacaacta aattaaaaac ttgagattga
    10861 aaaatcccca taaacttatt ttacaaggag gtaaggctat ggtaaccatt aaacaagttg
    10921 ctgaagaagc aggtgtttct agatcaacag tctccaggta tatttctcaa aaaggatatg
    10981 tatctgatga tgcaaggcat aaaatcaaag cagcgatagc aaaattacat tacactccaa
    11041 atgtcttggc gcagtcattg aagacgaaaa aaaatcaact agtcggttta ttattaccag
    11101 acatttccaa tccttttttt ccgaggttag caagaggagc agaagaatat ttaaaagaaa
    11161 aggggtatcg ggttatgcta ggaaatattt cagacagcga agctcttgaa gaagaatacg
    11221 tccatgtcct tcttcaaagc aatgctgctg gcattattac tacccatgac tttacaaagc
    11281 ggtatcctac tcttgctatt ccagttgtag tggtagatcg tgttgaccaa gagacccagt
    11341 acggtgtctt ttcagataat agggcagggg gcttattggc ggctcagact gtctggcaag
    11401 caggggcgaa agaagttctg ttaataagag gtccgctgga taatgctgaa aacattaatg
    11461 agcggtttga agctagtttt tcttaccttc aaaaacaaga cgtgactatg tatgtgtgtg
    11521 atagtcagaa ttttgatttt gaaagtattc agctagaagc tagttacaac ctcaagtgtt
    11581 acccaacaat agatagtatt atagcacctt ctgatatcca tgctattgct tatattcatg
    11641 aactgcattc tcaaggtaaa aagattcctc aagatgttca aataataggt tatgatgaca
    11701 ttttaatgag tcaatttatt tatccttctt tatcgactat tcatcaatcc tcttatttga
    11761 tgggccgtta tgccgccgaa ttagtttata ctattgctag tcaattaact gtgaaagcaa
    11821 atcggattaa attgcctgtt cactacgttg agcgagaaac aataaggaaa agataagtaa
    11881 taatattagt ccagatttta gcaggtatga tgaagattta ttgggattta ccttctactt
    11941 taaaagatgt tatctgtcat tactttcatc gctatcagtc aaaacgcatt cttatgcaac
    12001 tcttaacctt aagcttaatg tctttttgat aacatagagg aatgttacac gatgatgacg
    12061 caataaagcc taaatatagt aattgtcgtg attttatagc tagtgagtaa tgagatagca
    12121 agtctctcat ttacttacaa aagtcaaaaa atagtgtata atggttgagt tacagataac
    12181 actgcaaaaa agataacaag tgtccataat tatctaagac tataaaggcg atatagacag
    12241 atataaaaaa gatgacgaat cagttatcac tggacaatta accgatttag ttacaactaa
    12301 tggatttttc agaaaggtgt caaatgaaaa aagaaatttc gccagaaatg tacaactata
    12361 ataaatttcc aggtcccaaa tttattcatt ttgaagagca agttaaggct gaaggcattg
    12421 atttgttact cttagaagat gttaagaacg cttttgatac gactagcttt ggtcaacgtt
    12481 atacagaagt tctcctaaag tatgactata ttgttggcga ttggggaaat gaacagcttc
    12541 gtcttaaagg gttttataag gatagtgatg atatcaagaa aacgaatcgc atctcacgtt
    12601 tagaagatta tattaaagaa ttttgcaatt ttggttgtgc ttattttgtt ttagaaaatc
    12661 ttcatccaca agatattaaa tttgaagagg agcgccaacc aagacgaaag aaatcaccta
    12721 aatcaaaatc aaatcgtcgc aagccaaact attcaaatca gcagcccgca acacctaaga
    12781 gtaaatcgaa gcgggtatca aaagaaaagc aacctgaaaa ccaagcgttt accagtcaaa
    12841 aacgtcgaag taatactaag cataaagaaa agtcaaaacg taatcagact agtcaactta
    12901 ataccaaaat tagtcatttt atcatcagaa agaaagataa ataatccatg aaaccatcga
    12961 tttatagctt aacacgcgat gaactgatcg cgtgggcagt tgaacgcggc caaaaacagt
    13021 ttagagctac tcaaatttgg gattggctct ataaaaaaag agttcaatct tttgaggaga
    13081 tgacgaatat ttctaaagat tttgtttcta ttttaaatga tagtttctgt gtcaatcctt
    13141 taaaacagcg agttgtacaa gagtcagctg atggtacagt aaaatattta tttgaactgc
    13201 ccgatggtat gttaattgaa acagttttaa tgcgtcaaca ttatggtcat tctgtttgtg
    13261 tgacgactca agttggctgt aacattggct gtactttttg tgctagtgga ttgatcaaaa
    13321 agcaacgtga tctaaacagt ggggaaatta cagctcaaat catgttagtc caaaaatatt
    13381 ttgacgatag aaagcaaggt gagcgggtta gccatgttgt cgtaatgggc attggtgaac
    13441 cttttgataa ttacaaaaat gtcatgtgct ttcttcgcgt catcaacgat gataatggct
    13501 tagcaattgg tgcccgtcat attacagtct ctacctcagg gttagctcac aagattcggg
    13561 attttgcaaa cgagggagta caggttaatt tagcagtctc gttgcatgca ccaaataatg
    13621 atttacgttc aagtattatg cgagtaaatc gctcttttcc gctggaaaag ctcttttcag
    13681 ctatagaata ctatattgaa aaaacgaatc gtcgtgtcac ttttgaatac attatgctaa
    13741 atgaagttaa cgatagcatt aagcaagctc aagaattagc agacttaact aaaactattc
    13801 gtaagttatc ttatgttaac ttgattccgt ataatcctgt ttcagaacat gatcagtata
    13861 gtagaagtcc taaagagcga gttctagcgt tttatgatgt gctaaagaaa aatggagtta
    13921 actgtgtggt gcgtcaagag cacggaacag atattgatgc agcctgtggc cagttacgtt
    13981 ctaaaacgat gaaaaaagat cgcgaaaagg ttacagcgac aaaataaagc ccaaaaaata
    14041 tctttgattg acaatgcttg atgacaaaat attcctagtc actaaaatga ctaggttttt
    14101 tatctggcct aaaaatgctc tagaagcaca atccaaaata atccaaaact aagataagga
    14161 ataaaaggta tgcgcttgat gcctaacagt aagcaagcag taatacctgc taaactagca
    14221 agttgaatta gccaaatcaa cgacgttaga tccaatacta aagctaagct agcaaggtag
    14281 aaaaaatcgc ctgctccaat tgaaaaaggt cttaaatgag ctaataaacc tagtagcagt
    14341 aatatcaatg ataaataatt gatcgaataa aacaggagta gacttacaaa gctaaaaagc
    14401 cacaagataa aagggtatcc ttgagaacgc caatcaaata aactaaataa taaagaaaag
    14461 agtaacaagt aacagtaact agcactaacc caatgtacca tactagccca taagataatt
    14521 attagactta tctctaagct aaagaagatt ttttggctag ttataaaatg gttttggagc
    14581 tgccgaaaaa cgcgtttggc aaaagttagt tggttacaaa caatgacagt ctgtttactt
    14641 agctgttctt gaccattatc aggaaaataa agtagtaaac agtaaaaaaa gatgggtcaa
    14701 taagatgccc gaacatatac taaaaaaagc tatcatactt atttattcga aaagaaatca
    14761 aatacttgca atctttcctt aatcattgta gaatatagat ataaaacgat aatgattcta
    14821 attaagtgta taatcatcca attaggatta ttccgttatt gtcgaatagg attaggtcct
    14881 taaccctttc ttatgtttat cacgttaggg ttagttcccc ctccattctt gccctttaag
    14941 ctgaaaagta aggagatgtt attatgacaa acacactcgt tgaaaatatt tatgcttcag
    15001 taactcacaa tatttctaaa aaagaagcat caaaaaatga aaaaactaaa gctgttttaa
    15061 accaagctgt cgctgactta tctgtcgctg catctattgt gcaccaagta cactggtata
    15121 tgcgtggtcc aggtttcttg taccttcacc ccaaaatgga tgaattactt gatagcttga
    15181 atgctaattt agatgaaatg agcgagcgtt tgatcactat tggcggagcg ccttattcta
    15241 ccctagctga gttttctaaa cactctaaat tggatgaagc aaaaggtact tacgataaaa
    15301 ccgttgctca gcatttagca agattggtcg aagtttacct ttacctcagc agcctttacc
    15361 aagttggttt ggatattacc gatgaagaag gcgatgctgg aacaaacgat ttgtttacag
    15421 cagctaagac agaggctgaa aaaaccattt ggatgctcca agcagagcgt ggacaaggcc
    15481 cagcactcta atggattatg ccttaggata aaagaagtca atgataaaat tggctttttt
    15541 tttatggaat catcgattca ttttcagaaa catagaaagc gattccataa ttgtcttgaa
    15601 atctgccgta gaatttgcta aaatctactt atatgaaaac actatatgat gtgcaacaat
    15661 tgctaaaaaa ctttggcatt tttgtttacc ttggcaaacg tctctatgat attgaaatga
    15721 tgaagattga acttcagcgt ctctatgata gcggcttatt ggataagagg gattacttaa
    15781 atgcggagtt aattttgcga cgtgagcata gattagaatt ggaaaaagaa ggataggcaa
    15841 atgagtcaaa aattactggg gattgattta ggtggtacca ccattaaatt tggaatttta
    15901 acagcagcag gagaagtcca agaaaaatgg gcaattgaga ctaatatttt agaaggaggc
    15961 aagcatattg ttcccgatat catcgcttcc atcaaacatc gcttagactt gtatgatcta
    16021 agcagtgctg attttgtggg aattggtatg ggatcaccag gagcggttga ccgtgatact
    16081 aatacagtta ctggggcatt caaccttaat tggaaagaaa cccaagaagt cggttccgtt
    16141 gttgaaaaag aattgggcat tccttttgcc attgacaatg atgctaatgt ggctgccctt
    16201 ggtgaacgtt gggtaggtgc tggtgaaaat aacccagatg tcgtcttcat gacacttgga
    16261 acaggtgtcg gtggaggcat tattgctgat ggtaacttga ttcatggtgt tgcaggagca
    16321 ggtggtgaaa tcggccacat gattgttgag ccagaaaatg gctttgcttg tacttgtggc
    16381 tcacacggct gtttggaaac agtagcttca gcaacaggag ttgtcaaagt ggcacgttta
    16441 ttggcagaag cttatgaagg ggattcagcc atcaaagcag ctattgacaa tggtgaaggt
    16501 gttaccagca aagatatttt tatggcagct gaagcagggg attcctttgc tgattctgtt
    16561 gtggaaaagg ttggttacta ccttggcctt gcttcagcaa atatttccaa tatattgaat
    16621 ccagactcag tggttatcgg tgggggtgtg tcagcagcag gagaatttct acgctcacgt
    16681 attgaaaaat actttgtgac cttcactttc ccacaagtga ggtattcaac taaaattaag
    16741 attgcagagc ttggcaatga tgctggaatt atcggtgcag ctagccttgc tcgacaattt
    16801 atcacaaaat aggaggggga tatgtctcca atcacactta tcttatggtt acttcttgtc
    16861 ggcattgttg gttatcatac atggaactat ttctcttttc gaaaaatggc aaagcaggtt
    16921 gataacgaga cttttaaaga cgtgatgcgt caaggtcaat tgattgattt acgagagcca
    16981 gcggctttta gaactaagca tattttagga gctcgaaatt ttccagcgca acaatttgat
    17041 gctgctatca aaggtcttcg caaggacaaa cctgttctta tctacgaaaa tatgcgtccc
    17101 cagtaccgtg tgcctgcggt caaaaaactt aaaaaagctg gctttgaaga cgtttatgtc
    17161 ttaaaagacg gtattgatta ttgggatggc aaagttaaac aaacaaccta gttaagagta
    17221 acgtggagtt aaggggaata aaggcagtca ctgtctcaaa aaccttaatt cctttttttg
    17281 ctgtatccag acttgctgaa agtctgaaaa catttacaat tgattaaaac cagtttttta
    17341 aaacattttg tgttatactt atctagttaa aatatattta cttagaggaa caaatgacta
    17401 acttaagaaa cgatatccgt aacgtagcga ttattgccca cgttgaccac ggaaaaacaa
    17461 cacttgtaga tgaattatta aaacaatccc atactcttga tgagcgtaaa gagcttcaag
    17521 agcgtgccat ggattccaat gaccttgaaa aagaacgtgg gattacgatc cttgcgaaaa
    17581 atacggcagt agcctataac gatgttcgta ttaacatcat ggatacccca ggacacgcgg
    17641 acttcggtgg tgaagttgaa cgtatcatga aaatggttga cggggttgtt cttgttgtgg
    17701 atgcctacga aggaacaatg ccccagacgc gtttcgtatt gaaaaaagca cttgagcaaa
    17761 accttatccc gatcgttgtg gtgaacaaga ttgacaaacc ttcagctcgt ccagcagaag
    17821 ttgtagatga agtgcttgaa ttattcatcg aacttggtgc cgatgatgag caattggaat
    17881 tcccagttgt ttacgcatca gctattaatg gaacatcatc attatcagat gaccctgctg
    17941 accaagagca tactatggca ccgatctttg atacgattat tgatcatatt ccagcgccag
    18001 ttgataattc agatgagcct ttgcaattcc aagtgtcact tttggactac aacgatttcg
    18061 taggtcgtat cggtatcggt cgtgttttcc gtggtactgt taaagtgggt gatcaagtaa
    18121 ctctttcaaa acttgatggt accactaaaa acttccgtgt tacaaaactg tttggtttct
    18181 tcggtttgga acgtcgtgaa attcaagaag ctaaagcagg tgacttgatt gctgtttcag
    18241 gtatggaaga tatctttgtt ggagaaacca ttacaccaac tgactgtgtg gaagctctgc
    18301 caattcttcg tattgatgag ccaacacttc agatgacttt cttggtcaat aactctcctt
    18361 ttgcaggtcg tgaaggtaaa tggatcacgt cacgtaaggt tgaagaacgt cttttagcag
    18421 aattgcaaac agacgtgtca cttcgtgttg acccaacaga ttcgccagat aaatggacgg
    18481 tttcagggcg tggagaattg cacttgtcaa ttcttatcga aaccatgcgc cgtgaaggct
    18541 atgaacttca agtatcacgt ccagaagtta tcatcaaaga aattgatggt gtcaaatgtg
    18601 aaccgtttga gcgtgttcaa attgatacac cagaagaata tcagggtgca atcatccagt
    18661 ctctttcaga acgtaaaggg gatatgcttg atatgcagat ggttggtaat ggtcaaacgc
    18721 gtttgatttt cttgattcct gcacgtggtt tgattggtta ttcaacagag tttctttcaa
    18781 tgacacgtgg atatggtatc atgaatcata cttttgatca gtatctaccg gttgttcaag
    18841 gagaaattgg tggccgtcat cgtggtgcct tggtttctat tgaaaatggg aaagcaacga
    18901 catattcaat catgcgtatt gaagaacgtg gaactatctt tgtcaatcca ggtacagaag
    18961 tttacgaagg gatgattgtt ggtgaaaact cacgtgataa cgaccttggt gttaacatta
    19021 caacagctaa gcaaatgaca aatgtccgtt cagcgactaa agatcaaact gcagttatca
    19081 agacgcctcg tatcctaacg cttgaagaat cattagagtt cttgaatgac gacgaataca
    19141 tggaagtaac gccagaatct atccgcttgc gtaaacaaat cttgaataaa gctgcgcgtg
    19201 ataaagctaa taaaaagaaa aaatcagccg aatagctttt gaagttaaac taactaaata
    19261 aaatagcaaa aagatattta agaaaagtca ttttttaaag gtctttttgc gtttacaagt
    19321 tcctatggaa tataaaccaa aataaaggag gacggaatgt tttaccttat tatggctgtc
    19381 ttgattatat cttattatct atacatggct cctaaaagtg tccgtaacac ccttgggatg
    19441 attggtttag ttggcttggt tgctctgctt attgttttag cgggcttgag ttttatcaaa
    19501 atcatgcaaa cccctcctga attttttatt gggatgggaa tggtggcatt gggctatttt
    19561 gctttaaaag atgtgcgtaa aatgaccaaa aaaccgagag ttaaataaaa atacttaaag
    19621 attgatgatt ttggttttta tacgataaaa ggactgattt gttttagaca atatcagtcc
    19681 ttttttaata gttcattttt tctgaaagaa agcttttagc cgattttcat tgagtgtgca
    19741 actaaaaaga gatgcttggt agtgacagtt aagacctctg actagtattt tatcttattt
    19801 tacttaaaaa agcgtaccaa taatctcaca aatatgggca tgatgtttgt atattggaaa
    19861 cggattctaa ttctaaactc aagaacggta tttttaaaat gttgaaaaag catctaaata
    19921 aaggtaaaat agaaatcaaa tagaatggat agtgtgagct tagatgaaag tgataagtaa
    19981 ttttcaaaac aaaaaaatat taatattggg gttagccaaa tcgggcgaag cagcagcaaa
    20041 attattgacc aaacttggtg ctttagtgac tgttaatgat agtaaaccat ttgaccaaaa
    20101 tccagcggca caagccttgt tggaagaggg gattaaggtc atttgtggta gccacccagt
    20161 agaattatta gatgagaact ttgagtacat ggttaaaaac cctgggattc cttatgataa
    20221 tcctatggtt aaacgcgccc ttgcaaagga aattcccatc ttgactgaag tagaattggc
    20281 ttatttcgta tctgaagcgc ctattatcgg gattacagga tcaaacggga agacaaccac
    20341 aacgacaatg attgccgatg ttttgaatgc tggcgggcaa tctgcactct tatctggaaa
    20401 cattggttat cctgcttcaa aagttgttca aaaagcaatt gctggtgata ctttggtgat
    20461 ggaattgtcc tcttttcaat tagtgggagt gaatgctttt cgccctcata ttgctgtcat
    20521 cactaattta atgccgactc acctggacta tcatggcagt tttgaggatt atgttgctgc
    20581 taaatggatg attcaagctc agatgacaga atcagactac cttattttaa atgctaatca
    20641 agagatttca gcaactctag ctaagaccac caaagcaaca gtgattcctt tttcaactca
    20701 aaaagtggtt gatggagctt atctgaatga tggaatactc tattttaaag aacaggcgat
    20761 tatagctgca actgacttag gtgtcccagg tagccataac attgaaaatg ccctagcaac
    20821 tattgcagtt gccaagttat ctggtattgc tgatgatatt attgcccagt gcctttcaca
    20881 ttttggaggc gttaaacatc gtttgcaacg ggttggtcaa atcaaagata ttaccttcta
    20941 caatgacagt aagtcaacca atattttagc cactcaaaaa gctttatcag gttttgataa
    21001 cagtcgcttg attttgattg ctggcggtct agatcgtggc aatgaatttg acgatttggt
    21061 gccagacctt ttaggactta agcagatgat tattttggga gaatccgcag agcgtatgaa
    21121 gcgagctgct aacaaagcag aggtctctta tcttgaagct agaagtgtgg cagaagcaac
    21181 agagcttgct tttaagctgg cccaaacagg cgatactatc ttgcttagcc cagccaatgc
    21241 tagctgggat atgtatccta attttgaggt tcgtggggat gaatttttgg caacctttga
    21301 ttgtttaaga ggagatgcct aatgcctaag aagattttat ttacaggtgg tggaactgta
    21361 ggtcatgtca ccttgaacct cattctcata ccaaaattta tcaaggacgg ttgggaagta
    21421 cattatattg gtgataaaaa tggcattgaa catacagaaa ttgaaaagtc aggccttgac
    21481 gtgacctttc atgctatcgc gacaggcaag cttagacgct atttttcatg gcaaaatcta
    21541 gctgatgttt ttaaggttgc acttggcctc ctacagtctc tctttattgt tgccaagctt
    21601 cgccctcaag cccttttttc caaaggtggt tttgtctcag taccgccagt tgtggctgct
    21661 aaattgcttg gtaaaccagt ctttattcat gaatcagatc ggtcaatggg actagcaaac
    21721 aagattgcct acaaatttgc aactaccatg tataccactt ttgagcagga agaccagttg
    21781 tctaaagtta aacaccttgg agcggtgaca aaggttttca aagataccaa ccaaatgcct
    21841 gaatcaactc agttagaggc ggtgaaagag tattttagta gagacctaaa aaccctcttg
    21901 tttattggtg gttcggcagg ggcgcatgtg tttaatcagt ttattagtga tcatccagaa
    21961 ttgaagcaac gttataatat catcaatatt acaggagacc ctcaccttaa tgaattgagt
    22021 tctcatctgt atcgagtaga ttatgttacc gatctctacc aacctttgat ggcgatggct
    22081 gaccttgtag tgacaagagg gggctctaat acactttttg agctactggc aatggctaag
    22141 ctacacctca tcgttcctct tggtaaagaa gctagccgtg gcgatcagtt agaaaatgcc
    22201 acttattttg agaagagggg ctacgctaaa caattacagg aacctgattt aactttgcat
    22261 aattttgatc aggcaatggc tgatttgttt gaacatcagg ctgattatga ggctactatg
    22321 ttggcaacta aggagattca gtcaccggac ttcttttatg accttttgag agctgatatt
    22381 agctccgcga ttaaggagaa gtaaatggca aaagataaag agaaacaaag tgatgacaag
    22441 ctcgttttga cagagtggca aaagcgtaac attgaatttt taaagaaaaa gaagcagcaa
    22501 gctgaggaag aaaaaaaact caaagagaaa ttattgagtg ataaaaaagc gcagcagcaa
    22561 gctcaaaatg cttctgaagc agttgagctt aaaactgatg agaaaactga tagtcaggaa
    22621 attgagtcag aaacgacgtc aaaacctaaa aaacccaaaa aagttagaca acccaaggaa
    22681 aaaagcgcga cacaaatcgc ttttcaaaaa tccttgcctg ttcttttggg ggcgctctta
    22741 cttatggcgg tgtctatttt tatgatcact ccttatagca aaaagaaaga gttttctgta
    22801 agaggaaacc atcaaacgaa ccttgacgaa ttaatcaaag ctagcaaagt caaagcatct
    22861 gactattggt taacgttgtt aacttcgcct ggtcagtatg aacgaccgat tcttcgtact
    22921 attccatggg tgaaatctgt acacctctct taccaatttc ctaatcactt tctatttaac
    22981 gttattgaat ttgaaatcat cgcttatgca caagtcgaaa acggttttca gcctattttg
    23041 gagaatggaa aacgtgtgga caaggtcagg gcatcagaac taccaaaatc tttcttgatt
    23101 cttaatttaa aagatgagaa agcgatccaa cagttagtta agcaattaac gacattacct
    23161 aaaaaattag tcaagaatat caagtcagtg tctcttgcaa attccaaaac gacagcggat
    23221 ttactactta ttgaaatgta tgacggtaat gtagttagag taccgcagtc acaactcaca
    23281 ttgaaacttc cctattatca aaaattgaaa aaaaaccttg aaaatgatag tatagtggat
    23341 atggaagttg gaatttatac tacaacacag gagattgaaa atcaacctga agttcctctt
    23401 acgccagaac aaaacgcagc tgataaagaa ggagataagc ctggtgaaca tcaggaacag
    23461 acagacaatg attcagaaac accagcaaat cagagtagtc ctcagcaagc accaccattc
    23521 ccagaaacgg tcctcgaaca ggcccatggc tagctaatat ctaagttgaa aaagcaaaga
    23581 aaacgttaga aattcaacga ttctaaccca taatgaattg cctaaaaaaa ttaagtttat
    23641 ataacaaaaa acgtaaaatg ataacatttt acgttttttt atggtataat attttctgaa
    23701 tgattctgtt ttttagcagt ttttagaata gcaaaagttt ggaaagtaag tgaggtcaag
    23761 tgaatggcta gaaatggctt ttttactggt ttggacattg gaacaagttc gataaaagtt
    23821 ttagtagcag aatttatttc tggtgagatg aacgtcattg gtgttagtaa tgttccaagt
    23881 accggcgtaa aagatggcat aataatcgat atagaggcag ctgcgactgc catcaaaact
    23941 gcggtagaac aagcagaaga aaaagcaggg atgacaattg aaaaggttaa tgttgggcta
    24001 ccggcaaacc ttcttcaaat tgaaccaaca caaggaatga ttcctgtccc aagtgagtct
    24061 aaagagataa aagatgagga tgttgatagc gttgttaaat cggctttaac aaaaagtatc
    24121 acaccagaac gagaggttat ctctttagtt ccagaagagt tcattgtgga tggctttcag
    24181 ggcattcgag atccacgtgg tatgatgggg attagattag agatgcgcgg gcttatttat
    24241 actggaccaa gcaccatttt acataatctg cgtaaaacgg tagaaagagc aggcattaaa
    24301 gttgaaaaca tcattatttc tccgttagct atggctaaaa ccattttaaa cgaaggtgag
    24361 cgcgagtttg gagctactgt aattgatatg ggaggtggac agacaactgt cgcttctatg
    24421 cgagcacaag aattgcagta taccaatata tatgctgaag gcggcgaata cattactaaa
    24481 gatatatcaa aagtattaaa aacgtctttg gctattgcag aagcacttaa gtttaatttt
    24541 ggtcaagcgg agatatcaga agctagtata actgaaacag taaaagttga tgtggtaggt
    24601 agtgaagagc ctgttgaggt aactgaacgt tatttatctg aaattatttc agcgcgtatt
    24661 cgtcatattt tagatcgtgt gaagcaagat ttggaaagag gtcgtttact agacttacca
    24721 ggaggcattg ttttgattgg tggcggtgca atcatgcctg gagtggtaga gattgcacaa
    24781 gaaatctttg gagtaactgt aaagctccat gttccaaatc aagtcggtat tagaaatcca
    24841 atgttttcaa acgttatcag tttggtagaa tatgttggta tgatgtctga agtagacgtt
    24901 ttagcacaaa ctgcagtttc aggagaagaa cttttgcgac gcaagcctat cgatttcagt
    24961 ggtcaagaat cttatttacc agattatgat gattcaagaa gaccagaatc gaccattggc
    25021 tatgaacaac aagcgtcaca aacagcatat gattcacaag ttccgagtga tcctaaacaa
    25081 aaaatttcag aacgtgttcg tggcatattt gggagtatgt ttgattaaaa gtaataaagt
    25141 gaggagataa aatggcattt tcatttgata ctgcatcaat tcaaggtgca attataaaag
    25201 taattggagt cggcggaggt ggcggaaatg ccattaatcg tatgattgat gaaggtgttg
    25261 ctggtgtcga gttcatcgca gcaaacacag acattcaggc attaagctca tcaaaagctg
    25321 aaacggttat tcaactaggc cctaaattaa ctcgtggact tggtgctgga ggacaacctg
    25381 aagtaggacg taaagctgct gaagaaagcg aagaaatttt aacagaagct cttacaggag
    25441 cggacatggt atttattact gccggtatgg gtggtggctc tgggacaggg gctgcaccgg
    25501 ttattgctcg tatcgctaaa agtttgggag ccttgacagt agctgttgtt actcgcccgt
    25561 ttggttttga aggtaacaaa cgtggtaatt ttgctattga aggtatcgaa gaactccgtg
    25621 aacaagttga tactttgtta attatttcaa ataataacct tcttgagatt gttgataaaa
    25681 agacaccttt attagaagca cttagtgaag ctgataatgt tttacgtcag ggagttcaag
    25741 ggataaccga cttaattact agtcctggcc ttatcaatct cgattttgcc gacgtgaaaa
    25801 cagttatggc aaataaaggg aatgccttaa tggggattgg gattggttct ggagaagagc
    25861 gcattgttga ggcggcgcgt aaggcaatct attcacccct attagaaaca actattgatg
    25921 gtgcacaaga cgttattgtg aacgttacag gaggtctcga catgacactc acagaagctg
    25981 aagaagcctc tgaaattgtt gggcaagctg ctggtcaagg cgttaacatt tggttaggaa
    26041 catctattga tgatactatg aaagatgaca tccgtgtgac tgttgtagca actggagtgc
    26101 gccaagaaaa agccgagcaa gtttcaggtt ttcgtcagcc taggactttt acccaaacca
    26161 acgcgcagca agtagcgggt gcacaatatg catcagatca agcaaaacag tcggttcaac
    26221 cagggtttga tcgtcgctca aattttgatt ttgacatggg ggagtctcgc gagataccaa
    26281 gtgcacaaaa ggtaatttct aatcataatc aaaatcaagg ttcagctttt ggaaattggg
    26341 atttgagacg tgataatatt tctcgtccaa cagaaggtga attggataac catcttaata
    26401 tgtcaacgtt ctcagctaac gatgacagtg atgatgaatt agaaacgcct ccattcttta
    26461 aaaaccgtta ataatggatt tactgacaaa taaaaagaaa atttttgaga ctatccgctt
    26521 atctacagag gcagcaaata ggactaatga tagtgtttca gttattgctg taacaaaata
    26581 tgtggatagt acaattgcag gtcagcttat cgaagcagga attgagcaca ttgccgaaaa
    26641 ccgtgttgat aaatttcttg aaaagtatga tgcgttaaag tatatgccag taaagtggca
    26701 tttaattggt accttacaac gtcgtaaagt caaggaagtt atcaattatg ttgattattt
    26761 tcacgctcta gattctgtga gattagcttt ggaaatcaac aagagagctg accatcctgt
    26821 gaagtgtttt ctacaagtta atatttctaa agaagagagt aaacatggtt ttaacatttc
    26881 tgagattgat gaagcgattg aagaaatagg taagatggag aagatacagt tagttggttt
    26941 aatgactatg gcaccagcaa atgccagtaa agaaagtatt ataactattt ttcgacaagc
    27001 aaatcaatta agaaaaaact tgcagttaaa aaaaagaaag aatatgcctt ttacagaatt
    27061 gagcatgggc atgagtaacg attatccaat tgctattcaa gaaggctcaa cttttattcg
    27121 gattggtaga gctttctttc actaatggag aataagatgg cttttaaaga tacatttaac
    27181 aagatgattt cttattttga cacggatgag gttaacgaag ttgaagaaga tgttacagca
    27241 tcaactgata acgttattcc aagatcacaa caatcagtca gagcaagtag tcatccaaaa
    27301 caagaaccta gaaacaatca cgtacaacaa gatcatcaag cgagatccca agaacagaca
    27361 aggtcacaaa tgcatccaaa acatggtact tctgaacgct attatcagca gtctcagcca
    27421 aaagaaggcc atgaaatggt tgacagaaga aaacggatga gcacttctgg tattgcaaat
    27481 cgccgtgagc agtatcaaca atcaacttgt tcagatcaaa caactattgc cttaaagtat
    27541 cctcgtaaat atgaggatgc tcaagaaatt gtggatcttt taatagttaa tgaatgcgtt
    27601 ttgattgatt ttcagtttat gctagatgct caggctagac ggtgtttaga ttttattgat
    27661 ggtgctagta aagtgctcta tggtagctta caaaaggtcg gctcttcaat gtacttactg
    27721 gctccgtcaa atgtatccgt caatatagaa gaaatgacta tcccacatac tacacaagat
    27781 attggctttg attttgatat gaaaaggcgg taaataaatg atattaatac tatctattct
    27841 tcttcgtctg atcaaagttt acacttattt attgattgct tacgcattaa tgtcatggtt
    27901 tcctggggca tatgattcaa aaattgggcg tttgattagt ggtatcgttg aaccaatttt
    27961 aaaacctttt agagcattta atttacaatt tgccggtctt gacttcacta tttttgtcgt
    28021 cattattagt ttgaattttt tagctcaagt tttggtccgt gtgtttattt aatggttagt
    28081 catagtaaga tttatcagca ttttcaccaa gaagaatatt cttttattga tagaatgtct
    28141 gatatgatta atagagttga agattactat cttttagaag ttactgagtt tttaaatcct
    28201 agagaagtga tgattttaaa aagtttgatt gctttaacag atctaaaaat gttcgtatca
    28261 acagattact acccaagcga atatggtcgt gtcattattg cacctggtta ctatgactta
    28321 gaacaaagtg attttcaaat agctttagta gagataagtt atcaggcaaa gtttaatcag
    28381 ttgacacata gtcaaatttt aggaacttta attaatgaat taggagtaaa acgaaattta
    28441 tttggagatg tttttgttga aatgggatat gcccagctca tgattaagcg ggagttattg
    28501 gattattttt taggaacaat tactaaaata gctaaaacta gtgtgaaatt aagagaagtt
    28561 aactttgatc agttaattag gtctattgat aacaaccaga ccctggatat tctagtttct
    28621 agttttcgat tagatggtgt agttgctact atcttaaaaa aatctcgaac gcaagttata
    28681 gcattaattg aagcaaataa gattaaggta aactatcgac tcgctaataa agcttcagat
    28741 aatctagtca taggggatat ggtgagtatc agaggtcacg ggcgttttac tcttttagca
    28801 gataatggag tgaccaaaca tggcaaacaa aaaataacac taagtaaaat gatacataaa
    28861 taaggagata caatggcact tacaacgcta gaaattaaag ataaaacttt taagacaaaa
    28921 ttccgaggat actgtgaaga agaagtcaat gaattccttg atattgttgt tgatgattac
    28981 gaagctcttg tacgtaaaaa tcgtgataac gaagcaagaa ttaaagatct tgaagaaaaa
    29041 ttatcttact ttgatgaaat gaaagagtca cttagccagt ctgtaatctt agctcaagaa
    29101 acagctgaaa aagtgaaagc aacggctaat gcggaagcaa caaacttggt tagtaaagcg
    29161 acttatgatg ctcagcattt attagatgaa tctaaagcta aagccaatca aatgttgcgt
    29221 gatgcaactg atgaggctaa gcgagttgcg attgaaacag aagaactaaa gcgtcaaaca
    29281 cgtgtgttcc accaacgttt aatctcatct attgagtcac aattaagctt atcaaattca
    29341 cctgaatggg atgaactgct acaaccgact gcaatctatc ttcaaaattc tgacgatgct
    29401 tttaaggaag ttgtgaagac cgttcttaat gaagacattc ctgaatctga tgatagtgcc
    29461 tcttttgatg caacacgtca gtttactcca gaagagttag aagaattgca acgtcgtgtt
    29521 gatgaaagca ataaggagtt agaggcttac caacttgact ctcaatctga ttctacgact
    29581 gagccagagg taaatctcag tgaaacacaa acgtttaaat taaatatcta aataaagaaa
    29641 aacaagatga tttgcttata atcacagcaa gcgggagatg atgagagtct cgtattccct
    29701 aagtattatc attatcattt tctaaaattt tcgctgaact acagtaagcg aggaggtttg
    29761 ttcaccttac gagcaaagag ggagcggtaa gtcttatgat atattatcgc tctgaactaa
    29821 ggtggtacca cgagctttcg tcctttttga gacgaggctt ttttcgttat agtcgcaagt
    29881 ttgtttaaaa ggagtttgaa ataatgaaat taaaagagac acttaatcta ggaaaaacag
    29941 cctttccaat gcgcgcaggt cttcctaata aagagccaca atggcaagca gcttgggaac
    30001 aagcagagct ttacaaaaaa cgtcaagaat tgaatgcagg taagcctgcc tttcatcttc
    30061 atgatggacc tccatacgct aacggcaata ttcacgttgg gcatgccctt aataaaattt
    30121 caaaagatat cattgtgcgt tctaagtcca tgtctggctt tcaagcgcct tatgtaccag
    30181 gttgggacac acacggcctt ccaatcgaac aagtcttggc taagcaagga atcaaacgta
    30241 aggagatgga tttagcagaa taccttgaga tgtgtcgtca atacgcttta agtcaggttg
    30301 ataaacagcg aaatgatttc aaacggttag gtgtttcggc agactgggaa aatccttatg
    30361 tcactttgga cccacagttt gaagctgatc aaattcgtgt ttttggagcg atggctgaaa
    30421 aaggttacat ctatcgtggt gctaaacctg tttattggtc atggtcttca gaatcggcct
    30481 tggcagaagc tgaaattgaa taccatgaca ttgattcaac ctctttatac tacgccaata
    30541 aagttaaaga tggtaaagac atccttgata ctaatacgta tatcgttgtt tggacaacaa
    30601 caccatttac ggttacagca tcacgcggtt tgactgttgg tcctgatatg gattatcttg
    30661 tggtgaaacc tgctggttca gaccgtcaat atgttgtggc agaaggtctt ttggatagcc
    30721 ttgctggaaa atttggctgg gaatcttttg aaactttagc cagccataaa ggagctgatt
    30781 tagagtacat tgtgacagaa cacccatggg atactgacgt agaagaattg gttatccttg
    30841 gtgaccatgt tacccttgag tcagggacag ggattgtcca cacagcacca ggttttggtg
    30901 aggatgacta caatgttggg acaaaataca aactggaagt tgctgtgact gttgatgaac
    30961 gtggcctaat gatggaaaat gcaggtccag atttccacgg acaattttat aacaaggtaa
    31021 cgccgattgt cattgataaa cttggtgatc ttttattggc acaagaagtg atcaatcact
    31081 cttacccatt tgactggcgg acgaaaaaac caatcatctg gcgtgctgta ccgcaatggt
    31141 ttgcttctgt ttctgatttc cgtcaagata ttttggatga aattgaaaaa acaaccttcc
    31201 atccatcatg gggtgaaaca cgcctttaca atatgattcg tgatcgtggc gactgggtta
    31261 tttctcgtca acgtgcttgg ggagttccgc ttcctatctt ctatgccgaa gatggcacag
    31321 ctattatgac taaagaagtg acagatcatg tggctgattt gttccaagaa aatggatcaa
    31381 tcatttggtg gcaaaaagaa gctaaagacc tattaccaga gggcttcact catccagggt
    31441 caccaaatgg cgagtttaca aaagaaactg atatcatgga cgtttggttt gactctggtt
    31501 cttcttggaa tggagtcatg aatgctagag aaaatctttc ctatccagcg gatctctact
    31561 tagaaggctc tgaccagtat cgtggttggt tcaattcatc cttaattaca tctgtggctg
    31621 ttaatgggca tgctccatat aaggctattt tatcgcaagg ctttgttctt gatggtaagg
    31681 gcgaaaaaat gtctaaatca aaaggcaata tcatttctcc aaatgatgtg gctaaacaat
    31741 atggtgcaga tattctccgt ctctgggtag cttctgtgga taccgataat gatgttcgtg
    31801 tttctatgga gatccttggt caagtctctg aaacttaccg taaaatccgt aacacccttc
    31861 gcttcttgat tgctaataca tctgatttca accctgttac ggatacagta gcttatgcag
    31921 acttaggagc tgttgataag tacatgacaa ttgtctttaa tcagttggta gcaacgatta
    31981 ctgacgctta tgagcgttat gactttatgg ctatttacaa agcagtggtg aactttgtta
    32041 cggttgattt atcagccttc tatcttgatt ttgctaaaga cgttgtctat attgaagctg
    32101 ccaatagctt agaacgtcgt cgcatgcaga cagtcttcta tgatatcttg gttaagatta
    32161 ccaagttatt gacgccaatc ttgcctcaca ccactgaaga aatctggtct tatctagaat
    32221 atgagtcaga agcatttgtt caattggcag aaatgcctgt ggcagaaact ttctcagctc
    32281 aagaggatat tttagaagct tggtctgctt tcatgacttt gcgtacccaa gctcaaaaag
    32341 ctttggaaga agcgcgaaat gctaagatta tcggtaaatc attggaagcc catttgacca
    32401 tctacgctag cgaagaagtg aaaaccttat tgactgcttt agacagcgat attgctttgc
    32461 ttttgatcgt gtctcaatta accattgctg acttggcaga tgcgcctgcg gatgcagtgg
    32521 catttgaagg tattgccttt atggtagaac atgccatagg tgaagtttgt gagcgttcac
    32581 gccgcatcga cccaactact cgcatgcgtt cttacaatgc atttgtctgt gatcacagcg
    32641 ctaaaatcat tgaagaaaat ttcccagaag ctgtggctga agggtttgaa gagagtggca
    32701 aataagtctt atcaagactt gaagtgacac tgagtaagaa gacaaccatc gggtcttagg
    32761 acctgatggt tttttagtag agctgattac gtccattagc cagctttaac gagagacaaa
    32821 gtaggagaaa tttagactac tttattaatt tcttttaaga aaattgctgg cttcatataa
    32881 ggactattaa gatagagttc acctttcgct aataaaaaaa cttagctctt ttagaagggc
    32941 taagttttgt ctgaatagct ggctgctgtt tatacagaag tttgaaatga aatttcaata
    33001 aggttattcg tgtgaagtgt ttttgattgt ccaggaataa caattttagg atcaatttta
    33061 cgttttaaaa aaaattcgcg aatgatatca agttcatcct ctttgatggc acggtattta
    33121 tttgaaataa gtagttcgta atgttttggt gcttgggtaa aaatgacatc tgtatttcct
    33181 gctgagtata cttcgactaa ataggcatcg gtgtttttta gctgatttct gatgagttct
    33241 gggtgactgc tagtggtatt gatgagtctc ataaatgtcc tccttagtat tcctgtacct
    33301 attatagcac taatttaaag ccttagttag tagaatgatg ctttttttgc cattccttga
    33361 ctccccattg atggctctct cgttttaatt tagcaattgc ctcgatagga gaaaaccaac
    33421 ctaagttatt aaaatcttct aagggcttag aaacggcttg aaatgcagtt acttcataaa
    33481 gataggcagg atggtagaag tgggtatcac gatggcgaga gtagaaatat tcatctgcct
    33541 gaccgtaata tgaaccaata gtagcagaaa aaccaagttc ttcaatcagt tcacgctcta
    33601 gggcctgaag ctgaccttca cctgcttcaa tttcaccacc aggtaaaaac caggaaccat
    33661 taggagcttg aacaagaata atttttgttt gttcgtgatt gggaatgata gcatagacac
    33721 cgtaacgtgt gacatagtca ttatgtgcat ttttatgtcc aaatgttgga atcatcattt
    33781 tatttacctt tcctttttct tcattatact aaatttttgc taattattct tatcaatttg
    33841 tttagtttaa taaaaaattg atagaaaaag agagagtctc cttatagaaa ctctcttagc
    33901 taacgttaat ctagagactt ttcgttaaga aaagaatctc cctctttaac agctttaatc
    33961 gtgatgtttt cactgtttgt catcagtgca cgtaactgtt tttcagttgg gtgttctaaa
    34021 taatagtctg taatggcatc ttcgatataa tcttggatag tacgacggag cggccgagcg
    34081 cccattttag gatcatagcc taaatctact aatttttctt tgaccttttg tgtcacatca
    34141 agatgaatcc cattatagcc taagcgctca ttaacatctt ccagcattaa atcaacgata
    34201 tgcagcaaat gttctttaga taaagctttg aattcaataa taccatcgaa acgattcata
    34261 aactctgggc tgaagaagtt gcttaattca ccaaggacag aacttgtccg tccttctcta
    34321 gcagcaccaa atccgacaga agcttcgctt ttacctgttc cggcattaga ggtcatgata
    34381 ataatggtgt ccttgaagct gactgttcgc ccttggccgt ctgttaagcg accgtcatca
    34441 agaacttgta agaacatgtg catgacgtca ggatgggctt tttccacctc atctaagaga
    34501 ataagggaat aaggattgcg acgaacttgt tcggttagct gtccagcttc ttcatagccg
    34561 acataacctg gaggagcccc gactaatttg gcgacagcgt gtttttccat gtattcggac
    34621 atgtcaaagc gaatcatatt gtttgtcgaa ccaaagagtt caatggctag ttgtttagac
    34681 aattcagttt taccaacccc agtcggtcca acgaataaga aagaaccaat agggcgattt
    34741 ggagttccta atcccacacg gttacgacga atagccttag cgattttatc aacagcatcg
    34801 tcttgcccga tcacgtgtgc tttcagatca ttggctaagt ttacgagttg agactgttcc
    34861 ttttctttta agtccccaac tggaatatta gttttttgct ctacaatagc ttcaatggtt
    34921 ttttcagtaa tgatgggaat atcttgctca tcgacttttt gagcctgcat ttctttgtat
    34981 tttgtaattt gatcgcggaa ataagctgcg cgttcatagt cttcgtctcg agtagcttgc
    35041 gccttgagat tctcagcttc aataagacgt ttgtcaattt ctttaggatc aacaaagttg
    35101 agggttagat tcattttgga accagcttcg tccagaaggt caatagcctt atcaggaaga
    35161 aaacggtctt gaatatagcg gttagataaa tgagcagcag cttcaatagc ggctgggcta
    35221 tatttgacat gatgatagtc ttcgtatttc ggttggatac cttttaaaat cgtgatggtt
    35281 tcctcaacag aaggttcatc aactttaacg ggttgcatac gtcgttctaa ggcagcgtct
    35341 ttttcaataa tacggtattc atttaaggtg gtagcgccga ccaactgcaa ttcaccgcgg
    35401 gccaaggctg gttttaaaat attaccagca tccatattgc cgtctcctgc agaaccagca
    35461 ccgacaatct catgaatttc atcaataaag agaatcacat ccttgcgatt gcgaatttct
    35521 tccattaatt tttgcatgcg ctcttcaaac tgaccacgga tacctgttcc ctgaacgagg
    35581 ctaaccacat caagacgaat cacttgcttg ccttggagtt tttgaggaac agtaccatca
    35641 ataatttttt gagccaaacc ttctacaaca gcagttttac caactccagg ctcaccaatt
    35701 agcacaggat tatttttagt acggcggttg aggatctcga taatgcgtgt aatctcttcg
    35761 tcacgaccaa taacaggatc aatattacca tttcttgcaa tatctgtgac attaatccca
    35821 aactcttcta acaagccctt tgcttgctga tttggtgttt gtggctgagc aggtcgttgt
    35881 ccgttgtagt taccaccata gcgtcctccg ccatttccat tttgccctgc ctgagtaggt
    35941 ggggtatttg gaagattacc aaaagctcta aaattattca aatcaccaaa aaagtcatca
    36001 aagaaaggac ttgtggatct atcttgtgct ctatatcctg gggttaggcc atttaaaata
    36061 gaattggcag gatcggattt catgatttga taacaatttt gacagagatc aacctgtctt
    36121 tgttttccat taacacttgt ataaagatga atagtagatt cgtttaaatt acaattttga
    36181 cacagcataa tatacctccg agggtttatc taaaagtcaa agtcatttag tcaaaaatgg
    36241 tcaaacttta tattcatatt atagcaccac ggcttgggaa atcaagtaaa aagtttatcg
    36301 ctttagcgtt agcttttaga gagtaatatg acagagtaac tttattaagt ttccaatgag
    36361 caaatgttta aaatcattga aaagagtaaa aaagtaaaat atcaataaat atattacttt
    36421 ccttgttagt ttcccttgtt ttgtgttaaa ataagaggga taaaaaacga ataggagaaa
    36481 cgaaatggaa tcacatttgg tgagaatcat caatcgtttg gagttgatgg tgacagatgg
    36541 cggtaatctc aagcgaaatt ttgaacgcga tggtgttgtt gttgcagaag ttgccttttc
    36601 aaatgatcct gaaaatggac ctgttttcac attgcgtgat gttgaggcgc gtgagtcata
    36661 ttcctttgat agcattgact tgattgcaat ggaaatctac gatttattat attaagcttg
    36721 acatagtaaa gagacttgcc tgaggcaggt ttttttattg tcaaaaagta ttgtattaat
    36781 attcatcaga tggtataatt atctttattg taatgaacct aggacttatg aggagatata
    36841 aatggatttg tcatttttgc ccaaatactg ggcctacttt aactacggtg tacttgtcac
    36901 cattatgatt tcagtcagcg ttgtcttttt tggaaccctt attggtgtct tggtaaccct
    36961 gattaagcgt agtcatgtga agccgttgac ctgggtcgtt aatctttacg tttggatctt
    37021 tcggggaaca cctatggtgg ttcaaatcat gattgccttt gcttggatgc attttaacaa
    37081 tatgcctact attggttttg gggttttaga cttggacttt tcaagactac ttcctggaat
    37141 tattatcatt tcattgaata gcggtgctta tatttcagaa attgttagag caggtattga
    37201 ggctgtacca aaagggcaat tagaagcagc ttattcacta ggtattcgtc ctcaaaatgc
    37261 catgcgttat gtgattttgc ctcaggcctt taaaaatatt ttgccagcct taggaaatga
    37321 atttattacc attattaagg atagtgctct tttacaaacc attggagtga tggaactttg
    37381 gaatggtgcc caatcggtgg taacggctac ttattctcca atttcccctt tactggtggc
    37441 tgctttttac tacttaatgg tcacaacagt gatggcacag ttattggcag tcttagaacg
    37501 tcacatggcg caaggaggta atcattgatg actgaggcta ttatttcaat taaagacttg
    37561 cacaagtatt atgggcacaa tgaagtgctt aagggaattg atttagacat tatgccagga
    37621 gaggttgtgg tgattattgg cccgtctggt tctggaaaat cgaccttact tcgaactatg
    37681 aatcttttgg aagtaccaac taagggacag attaggtttg aggggattga tattaccgat
    37741 aagaagaatg atattttcag catgcgtgaa aaaatgggaa tggttttcca gcagtttaac
    37801 ctctttccca atatgactgt tttagaaaat atcactttat cgccaatcaa aactaaggga
    37861 atggctaaag cagaggctga caaaacagcc ttgagcttgt tggacaaagt tggattatca
    37921 gaaaaagcca aggcttatcc tgctagtctt tctggtgggc aacagcagcg gattgcgatt
    37981 gcgcgtggac tggctatgga tccagacgtt ttactctttg atgaaccaac ttcagctcta
    38041 gatccagaaa tggtgggtga ggtcttggct gtcatgcaag atttggctaa atctgggatg
    38101 actatggtta ttgtgactca tgaaatgggc tttgctaaag aagtcgcaga ccgtgtgatg
    38161 tttatggatg gcggcgttat tgtggaagaa ggaagtccta accaactttt tgatctgact
    38221 aaagaagaac gtacaaaaga ttttttgagt agagtattat aaatctgttc tatgaattat
    38281 gaaaggaagt cctaaatcat ttagacttcc ttttataatt tgctaaggca ttttatagga
    38341 gattactttt ctttttgtta aaataaaaag aaatagttac attatttgca tagaagaaag
    38401 ggatctgtta tggtttcagt gatgtggttt cgtagagatt taaggattga tgatcaaaaa
    38461 gctttagctc atgttattgc tagtcaatca ccaaccttat gtgtgtttca atttaacaag
    38521 gagcaattaa acctgctaca tagtcggaat caatctagtt ttattactag cgttttggct
    38581 tttagaaagt tattaaaatg tgaaggtatt gacttatatc taatgtatgg agacttaatg
    38641 acctgttttg agcaattatt gacacaatta aaagactgga cagatgtgta ttttaactat
    38701 gatgaatctg gatatggtcg tttacgtgat caaaaagcag cacaattttt caaaaaaaat
    38761 gggattgccg ttcataccta ccaagatcac tatttacatg gtagtcaaga gatcattaac
    38821 caatcaggtc agccttataa agtttttacg ccctactata ggatttggca aaattatccg
    38881 aaagagactc ctattaaagt agaactatcg caaggcaggt ggttaaacct tgagacacca
    38941 gatgatgttt taaggactgt tgagagcttt aaagatgaaa aatatcagga tgttgcaact
    39001 tttgatgaag cgtcaaaaca actaaatcga tttattcaag accaattagc agcttatcac
    39061 gctaatcgag attttccagc gcagctaggg acgagtcggt tgtctccctt tttaagaata
    39121 ggagctattg gcattcgcac ggtatatcac gctgtgcgtc aagcaccaaa tagtctaggg
    39181 caagctactt ttttaaaaga attagcttgg agagactttt acaatatggt ctatgtggct
    39241 tatcctgatc agaaaactca gcctatccaa aaagcctttt ctcaaatcga atgggttaat
    39301 aatcctgact ggtttcagtt gtggaaagaa ggtaaaacgg gttaccctat tgttgatgct
    39361 gcaatgcttc agttacaaaa gacaggatgg atgcataatc gtttacgaat gatagtagct
    39421 tcttttttaa ctaaagatct tttatgtgat tggcgtttag gagagcagta ttttcaacaa
    39481 caactaattg attatgatgc tgccagtaat atcggaggat ggcagtgggc tgcttccact
    39541 ggaacagatg ctgttcctta ttttagaata tttaatcctg ttactcaagg taagcgcttt
    39601 gatcccaaag gcgagtttat taaagcatat ttgcctcaac tagaacacgt tccagagaag
    39661 tatctccacg aaccgtggaa gatgccaaaa aaccttcaag agagtgtgtc ctgtattatt
    39721 ggcacagact atcctcaacc aattgtcgat catgctaaac agcgtgaaca agctattgca
    39781 aagtatgagt gggcaaaaga aaaagcaaaa atagaatgac tgttctcatt ataagagttt
    39841 aaacaaaaag ttatcatgaa ttaagattat ttaatttaaa aaataagttg actttattta
    39901 gattatttga tactattcag ttgtctccct tagagaaagc gatttcttgt tttggagctg
    39961 atttttacca tttggtctta gaataggatg agtaatatga cttacaacga ggtatatcaa
    40021 gaatggttgc acaataatga tcttagtgat gatattaaag cagatttagc agccataaaa
    40081 gacaatgagg ctgagattca agatcgtttt tacaaaacac ttgaatttgg aacagcaggg
    40141 ctaagaggaa aacttggagc aggcaccaat cgcatgaata cctatatggt tggtaaggca
    40201 gcacaagctt tagctaatac tattattgat catggacctg aagcagttaa aaagggcatt
    40261 gcggttagtt atgatgttcg ctatcaatct agaacatttg cagaattaac atgctctatt
    40321 atggcagcta acggtattaa ggcgtacctt tataaaggga ttcggccaac accaatgtgt
    40381 tcgtacgcta ttcgtgcttt gggatgtatc tctggtgtta tgattacggc tagtcacaat
    40441 ccccaagctt acaatggtta caaagcttat tggcaagaag gttctcaaat tttggatgac
    40501 attgcggatc aaattgcaca acacatggct gcactaactc agtatcagga aatcaaacaa
    40561 atgccttttg aaaaggctct ggacagtgga cttgttactt atattgatga gagtattgaa
    40621 gaagcatata aaaaagaagt gcttggttta acgattaatg atactgacat tgataagtca
    40681 gtccgagtag tctatacccc tttaaatggt gttgggaatc taccagtgcg tgatgtttta
    40741 agacgccgcg gttttgaaaa tgtttatgtg gtacctgagc aggaaatgcc cgatcctgat
    40801 tttacgacag ttggctatcc taatcccgaa gtccctaaaa cttttgcata ttcagaaaaa
    40861 ttaggtaagg cagttgatgc tgatattttg attgcaactg atccagattg tgaccgtgtg
    40921 gctttagaag ttaaaaatgc agtcggtgac tatgtttttc tcaatggcaa taaaatcgga
    40981 gcgcttttat cttactatat cttttcacaa cgatttgact taggcaattt accggctaat
    41041 cctgttttag tgaaatccat tgtaacagga gacttgtcac gggctattgc tagccattat
    41101 ggtattgaaa ccgttgaaac attgactggt tttaagaata tttgtggcaa ggcaaacgaa
    41161 tatgatgtga cgaaacagaa aaactatctg tttggttatg aagaaagtat tggtttttgc
    41221 tatggcacct ttgttcgtga caaagacgct gttagcgcct ctatgatgat tgtagaaatg
    41281 gcagcttact acaagaaaaa ggggcagaat ttactagatg ttttgcagac tatttatgcg
    41341 acatttgggt attataatga acgtcaaatt gccttggaac ttgaggggat agaaggacaa
    41401 aaacgcattg cgaggataat ggaagatttc agacagacac caatagctag tgttgcagaa
    41461 atggcgttag acaagacaat tgattttatt gatggctatc aagattttcc aaagcaaaac
    41521 tgtctcaaat tttatttgga tgatggttct tggtatgcac ttagaccatc aggaacagag
    41581 cctaaaataa aattttattt atatactatt ggccaaacac aagaaaatag tgcaacaaaa
    41641 ttagatgcta ttgaagcagc gtgtcgcaca aaaataaatc aggttaatta aacatcaaaa
    41701 atggataaca cttttacact atttttccat ataaacaact acaaaaggag gtgagacttt
    41761 taggcacctt ctttttcttg taggtgccac taatcaattt aatcgactca aaccaatact
    41821 aaaaaataag taaaagtata aagaacaggc atctattttt ttgttataat agaaaaatga
    41881 aattaaaggg agatgtcaat gacagaacta attgatggta aagccttagc tcaaaagatg
    41941 caacaagagt tagcagctaa agtcaacaat ctaaaacaaa aaaaaggcat tgtaccaggc
    42001 ttagccgtta ttcttgtagg tgatgatcct gctagtcagg tgtatgtccg taataaagag
    42061 cgtgcagctc ttactgtagg ttttaaaagt gagaccgtta gattatcaga attcatttgt
    42121 caagaagagc ttattgcagt aatcgaacgt tacaatgcag ataacactat tcatggtatt
    42181 ttagtgcagc tacccctgcc aaatcatatt aatgataaaa aaattattct cgccattgat
    42241 cccaaaaaag atgtggatgg ttttcacccg atgaatacag gtcacctttg gtcaggacgt
    42301 cccttgatgg ttccttgtac tccatcaggg attatggaat tgcttcgaga atataatgtt
    42361 aaccttgaag gtaaacatgc cgtcattatt ggcagatcga atatcgttgg aaaaccaatg
    42421 gcacagctct tactggacaa aaatgcaaca gtcacgttga cacattcaag aacacgtcaa
    42481 ttagaagaag tatgtcgctg tgcagatgtg ttgattgtgg caatcggaca aggtcatttc
    42541 ataacaaaac aatatataaa agagggtgcg atagtgattg atgtgggaat gaaccgtgat
    42601 gataatggca agctaattgg agatgtggcc tttgatgagg tggcagaagt tgcagcgaaa
    42661 atcacccctg taccaggagg tgtcggtcct atgacgattg ctatgttgct agagcaaact
    42721 tatcaatctg ctctccgtag tactcataaa tagttatcat tagacaattc aacataagag
    42781 aatataagaa gtcagcaatg gcttcctttt ttgtttttct gctcactatt tattcagaaa
    42841 aatggtataa ttgcattagt atgcaaaggg actatgtcag gtccaactaa gtgaaaggtg
    42901 gcttgatggc agattattta accgtcactc atttgacgaa atatttaaaa ttaaaatttg
    42961 accgtgaccc ttatttggaa cgggtttatc tgactggtca agtgtccaat tttcgaaaac
    43021 gaccaactca tcaatatttt tccttaaagg acgaaagtgc tgtgattcaa gccaccatgt
    43081 gggcaggagt ctataaaaaa ctaggattcg acctagaaga aggcatgaaa attaatgtaa
    43141 ttgggcgagt tcaactttat gaacctagtg gctcttactc tatcgtgatt gaaaaggcag
    43201 agccagatgg tataggtgcc ttggctttgc agtttgaaca attaaagaaa aaattaacgg
    43261 cagaaggtta ttttgagcaa aaacacaagc agcctttgcc acagtttgta tcaaaaattg
    43321 gggtcattac aagtcctagt ggtgctgtga ttcgagatat tatcacaacc gtttcacggc
    43381 gttttccagg ggttgagatt ttattattcc cgactaaagt acaaggtgat ggagccgccc
    43441 aagaagtagt ggctaatatt cgaagagcca atcaaagaga ggatttggac ttgctcattg
    43501 tcggccgtgg aggtggctcg atagaagacc tttgggcctt caacgaggaa atagtggttc
    43561 aggctatctt tgaatcgcaa cttccagtga tttcgagtgt gggtcatgaa acagacacga
    43621 ctttagcgga ttttgtggca gatcgcagag cagccacacc aacagcagca gcagagttag
    43681 caacgcctat tacaaaaaca gatcttatgt cttggatagt agagcggcaa aatcgttcct
    43741 atcaggcctg cttgaggcgg attaagcaac ggcaagagtg ggtggataaa ctctcgcaat
    43801 ctgttatttt taggcaacca gaacgattat atgatgccta cctgcaaaaa attgatcgcc
    43861 ttagcatgac cctgatgaat acgatgaaag atcgtctgag ttccgccaaa gaaaacaagg
    43921 ttcagttgga ccatgccttg gccaatagtc aattacagac aaaaatcgag cgataccaag
    43981 accgtgttgc taccgctaag cgtttactga tggctaatat ggctagtcaa tatgatagtc
    44041 agctggctcg ctttgaaaaa gcacaggatg ctttgctatc actggatgcc agccgaatta
    44101 tcgcccgtgg ttatgcaatg attgaaaaaa atcaagcact ggtagcctct gtaagtcaga
    44161 taacaaaggg tgatcagtta accattaaga tgcgtgatgg acaattagat gtagaggtaa
    44221 aagatgtcaa aaacgaaaac atttgaagaa aatttacaag atttagagac tattgtgaac
    44281 aaacttgaaa atggggatgt ccctttggaa gaagctattt cagaatttca aaaaggaatg
    44341 cttctctcaa aagaacttca aaagacctta caagcggcag aaaaaacact cgtcaaagtg
    44401 atgcaagctg atggcacaga agtagatatg gatgattaat ggacaaatta gctagaattg
    44461 acgaagccat tcgtcgctac tataagacga ctagtaacgg tgtatctgaa gagttgattg
    44521 atgctatctt gtattctgtt gacagtggtg gcaagcgcat tcgaccactt atcttattag
    44581 agatgattga gggatttggg gtatcgttac agaatgctca ttttgatttg gctgcagccc
    44641 ttgaaatgat tcatacagga agtctgattc acgatgattt gccagccatg gataatgatg
    44701 attaccgacg tggtagactg accaatcaca aacaatttgg agaagccacg gccattttgg
    44761 cgggagatag cttattttta gacccctttg ggttaatagc tcaagctgaa ttaaatagcg
    44821 aggttaaagt agccttaatc caagaacttt ccctagcttc aggaactttt ggcatggttg
    44881 gtggtcagat gctagatatg aaaggggaaa atcaagcttt gagtctccct cagttgtcac
    44941 tgattcacct caataaaacc ggaaaattat taacttttcc ttttaaagca gcagctcttg
    45001 taacagaaca ggctattact gttcgtcaac aactagagca ggcgggaatg ctcatcgggc
    45061 acgcctttca gattagggat gatattttag acgtgacagc tagctttgaa gatcttggaa
    45121 aaacgcctaa aaaggattta tttgcagaaa aagctactta cccaagttta ctggggttag
    45181 aagcctccta ccaactgttg acagagagtt tagatcaggc tttgacgatt tttcagacac
    45241 tcgaaagcga tgtaggcttt aagcctcaaa taattacaaa actgatagaa gggttacgac
    45301 ttaatgccta aagaaagagt agatgtgtta gcctataagc aaggattatt tgagaccaga
    45361 gagcaagcta aacgtggtgt catggcaggc ttagtggtct ctgtgattaa tggccaacgc
    45421 tatgacaagc caggtgacaa aattgacgat gggactgagt taaaacttaa aggtgaaaaa
    45481 ctcaaatacg tcagtcgtgg tggattaaaa ctggaaaagg ggctgcatgt ttttggtgta
    45541 tcggttgcta atcaaattgg gattgatatt ggcgcttcaa caggtggttt taccgatgtt
    45601 atgttacaag atggggccaa actagtctat gccgtcgacg ttgggactaa ccagttggta
    45661 tggaaactca gacaagatcc acgagtaaga agtatggaac agtataactt tcgttatgct
    45721 cagccagagg actttaatga gggacagcct gtatttgcca gtattgatgt gtcctttatt
    45781 tctctcagct tgattttgcc agccctgcat aacgttttgt cagatcaggg acaggttatt
    45841 gctctcatta aaccgcaatt tgaagctggg cgcgagcaga ttggtaaaaa aggcatcgtc
    45901 aaagacaaac agattcatga aaaagtgatt caaaaggtca tggattttgc ctcaggttac
    45961 ggatttacag ttaagggact tgatttttcc cctattcagg gtggtcatgg aaatatcgaa
    46021 tttttagctc atcttgttaa gtcacagaca cctgaaacgt tagccccaca tctgattcag
    46081 gaagttgttg ccaaggcaca taaggagttt gagaaacatg aaaaaaagtg aacgacttga
    46141 attaatcaaa aaaatggttt tgacgcatcc aattgagacg caacatgatc tcttaagatt
    46201 attggcagag catgggttag aattaaccca ggctactatt tcaagagaca tgaatgaaat
    46261 tggtatagta aagattcctt ctggcagtgg acgttacatc tatggtcttt ctcaagatag
    46321 tggaaaaaag atcgttcaag gacctagatc gataaagagc actattttag ctgtatctga
    46381 caaaacaaaa ggtttagaac aacacctcta tttaaaagtc gtacctggca atagtaaatt
    46441 aatcaaacgt tatttattag cagatttttc aaaagctatt tttagtctta ttgctgatga
    46501 tgatagttta ctgttaattg caaagtctcc ttcagaagca gatatgatac gccaagaaat
    46561 tttgctttgg atgcagggta taacctagaa aaaatagggg agaaagtgat gttattagaa
    46621 atttccatta aaaattttgc tattattgat gaaatttccc taaattttga aaatggtatg
    46681 acggttttga cgggtgaaac tggagcagga aagtctatta tcattgatgc tatgaatatg
    46741 atgcttggtg cgcgtgctag tacagaagtg attcgtcgtg gagctaataa agcagaaatt
    46801 gaggggttct tttcggtaga tgctacccca gaactggttg cgtgtctgga atcatcaggt
    46861 attgctatgg aagaagaact gattattcgc cgagatatct ttgccaatgg cagaagcgtg
    46921 agtcgcatta atggtcagat ggttaaccta gcgaccttaa aacaggtcgg acagtttttg
    46981 gtagatattc atgggcaaca tgaccaagaa gaattaatgc gaccacagct ccaccagcaa
    47041 attttggacg cttttggtga taaggctttt gagcaattga aagagaacta tcagcttatt
    47101 tttgatcgtt ataaaagctt gcgtcgccag gttattgaca aacaaaaaaa tgaaaaggaa
    47161 cacaaagatc gtattgatat gttggccttt cagatagcag aaattgaagc tgctgccttg
    47221 agtcgaggtg aggacgaccg gttaaatcaa gaacgtgatc gcttaatgaa ccacaaacaa
    47281 attgctgata ccctgaccaa tgcctacgtc atgctagata atgacgattt ttcaagtcta
    47341 tccaatattc gctctagcat gaatgactta ctatcaattg agcagtttga ttcagagtac
    47401 aaagggatgt cgacttcgat ttctgaagcc tattatattc ttgaagaagt gagcaagcaa
    47461 ttatcagata ccattgacca actggatttt gatggtgggc gattacagga aattgaattt
    47521 cgcttggata cactcaatag cttaacccgt aaatacggtg gtaatgtgaa tgatgtgctt
    47581 gactactacg ataatattat caaagaatac cagctattaa caggagacga cttgtcttca
    47641 ggggatctag aatcagaatt gaaagcctta gaaaaacaat tggttgctgc agccactaac
    47701 ttgagtgaac gccgccatca attggcggag caattagaag ctgagattaa agctgaactt
    47761 aaggaacttt atatggaaaa agcagatttc aaagttcact ttaccacatc aaaattcaat
    47821 cgtgatggta atgaaagctt ggaattttac atctctacta atccaggcga aggatttaag
    47881 ccccttgtca aggtggcttc tggaggagag ttatcacgcc ttatgttagc catcaaggct
    47941 gctatttcta gaaaagaaga taagacgagt attgtttttg atgaagtaga tacaggtgtt
    48001 tctggtcgcg ttgcgcaagc cattgcccaa aaaatttata aaattgggcg acatgggcaa
    48061 gttctcgcta tttcacactt acctcaagtt attgctattg ctgattatca gtattttatt
    48121 tctaaagaaa gtaaagaaga gtccaccgtt tctaaggtaa ggttattaac tcctgaagaa
    48181 cgtgtggaag aaattgctag catgattgca ggaacagata tgacacaagc tgctcttacg
    48241 caggctcgtg aactacttgc caaacattaa gattatgttt ggtatttgat attttcataa
    48301 ttagatgaca ttgatttttt aggtgctaaa ataatcattg tgctagacca tttttcctct
    48361 gttaatctgg cttggtttgc cttgacaaac ctctgagaaa tagtagaata gataagagaa
    48421 ttttaagctg aggggataga aatgactagt aaaaaagcgt gtttatcaag catcattgtg
    48481 ttagcaagtt taacgtgtgg aaatgatact gttagtgcca atcatctctc agcaactgga
    48541 gataagtttg atgattgctc aacacttgtt gaaaaagatg tggcccctaa agatgaactt
    48601 gagatgttag catggtcctc gtctcaaaca actgatgatg ctgacagaga ctatgaagat
    48661 tttctcgatg atgattcttt tatttctcaa aatgaaactg ataagatgtt tgagaattta
    48721 actgatgata ggttattaaa tgaattagat gaatcagatg aagaagatga agaagataca
    48781 attgagccag agcaaaatgt aataatgcct agtgacgatg agctatttga tttaactgat
    48841 gctgttgaga cacgccttac tgtttctagt gctccccatt tagaggctga attgccgaaa
    48901 ccacatttga ggagcctatc agatacagca ctgcggtctg gtgaaattag aggacattta
    48961 gataacaaac tggacgcttt gtctgtaaca gctacaaagt tagcattaac gatggctcaa
    49021 aaatttgatt tgacaacgca tgtctattct ataggtgaaa gctttagtga agtattagct
    49081 gctcattatg aagacagaaa agcagaatca gctttttcta agaaaaagag atttcacctt
    49141 cctattgcta ctccagatgt tgttatagag gagttaaggc gcctagtctc ttctattgga
    49201 agttcaaaag aagatgtttc agttccttat aatcggaagc taggtatggc agttgcaaaa
    49261 agaaaaatag ccctgccaca aacgggagag gggttctctt attatccagt tttacttggt
    49321 ttaatgatat taggattaac gccgattatg ataccaaaga agataaataa ttaggtaata
    49381 agttattgta gttgtaaaaa acggggcaaa tgttcaagcg tgaaaaggtt gacttttgcc
    49441 tcgttttgta tctcgttatt gctaaggcat tttcttcgag cagctagtgc tcgccatacc
    49501 tatctaccga gtgattattc aatagcacta ccagttttgc tttatttagc aaggagtgtt
    49561 agaataaaga ggtgagaaac tagtttagaa tggaaaaata catgggaact ataaaaattg
    49621 ttacagattc atcaataact attgaaccag aattaattaa agctttagat attactgtag
    49681 tacctttatc tgtcatgatt gatagcaaat tatattctga taatgattta aaagaagaag
    49741 gtcatttttt gagccttatg aaggctagca aatcccttcc caaaaccagt cagccaccgg
    49801 ttggactctt tgctgaaact tacgaaaatt tggtcaaaaa aggagtaact gacattgttg
    49861 ctattcacct ctcaccagct ttatcaggta ctattgaagc ttcccgtcag ggggctgaaa
    49921 tcgctgaggc acctgttaca gttttagatt caggatttac tgatcaagcc atgaaatttc
    49981 aggtcgttga ggcagcaaag atggcaaaag cgggtgcaag tttgaatgag attttggctg
    50041 ctgttcaagc tatcaaatca aaaacagagc tctacattgg tgtatctacc ttagaaaatt
    50101 tagtaaaagg aggtcgtatt ggtcgtgtga cgggtgtttt gagctcgcta cttaatgtca
    50161 aagttgttat ggcacttaaa aatgatgagt taaaaacgct tgtcaaaggt cgaggtaata
    50221 aaacatttac gaaatggtta gatagttacc tcgctaaaaa tagtcatcgc ccgattgcag
    50281 agatagctat ttcttatgct ggtgaagcta gcctggcatt aaccttaaaa gaaagaatcg
    50341 cagcttatta taaccattct atttcggttt tagaaacagg ctctatcatc caaacacata
    50401 caggagaagg agcttttgcg gttatggttc gttatgaata atcgtcattt atttagtggg
    50461 atatttttct ttgttattag tttatgtctg gcctttttat tgttaaatat tattatccct
    50521 aagtcaaatt cacgtttgaa aaagagtgat tttctgaaaa aagaacaagt agctatccaa
    50581 tatgttgcta taggagattc attgacagaa ggagtaggtg atctaactca tcaaggtggt
    50641 tttgttcctt tgttaacgaa tgatctcagt gaatatttta aggctaatgt taatcatcaa
    50701 aattacggcg tatctggtga taccagtcaa caaattcttg ataggatgat aaaacaaaag
    50761 cagatacagt tatctttaaa aaaagcagat ataatgacgt taaccgttgg tggtaatgat
    50821 gttatggcag ttattcggaa gaatttagcg gatttgcaag tttctagttt tagaaagcca
    50881 gctcgtcagt atcaaaaacg attaagacag attatcgagt tagccagaaa agataataaa
    50941 gatcttccta tttttatttt aggcatctat aatccgtttt atttgaattt tccagaacta
    51001 actgatatgc aaaaagtgat tgatgactgg aataccaaaa ctaaggaggt tgttggagaa
    51061 tacgatcgtg tgtactttgt gccaataaat gacctcttgt ataaagggat aaatggacaa
    51121 gaaggaattg tccattcttc aggagatcaa actacaattg tcaatgatgc cttgtttact
    51181 ggggaccatt ttcacccaaa taatactggc tatcaaatca tgtcaaatgc agtaatggag
    51241 aaaataaaaa agcatgaaaa aaaaatcaaa ccttaattgg tggaagtgga gcttcttatg
    51301 tctgcttgct tttaataccg cctttttgat ggttattgca agtcgtctca ttcaagtaag
    51361 agaacctgag tcagaactga ttgctaaaaa accagttaaa aatatcaaaa ttggtacatt
    51421 tgtcacaacc agagaacagc ttaacgaaac tgtagcaagt tatcttaaag attatcagac
    51481 taaaaaaatg tcttataaat tttatgcgac atcttcttct attttgtttg aaggaactta
    51541 tcaattatta gggtatgaag tccctttata tatctatttt caacctcatc gtctagaaaa
    51601 tggagctgtc caactacagg tgatctcttt ttcagtggga actctgccac tcccagaaaa
    51661 agatgttttg cagtatttga aatcaagcta caaattgcca agctttgtta aagtgatgcc
    51721 aaatcaatca gctatcgttg ttaatttaca agatatccaa aatgatgcta aggtttattt
    51781 aaaggccaag aaaattgatt tatttaatga tgaaatcagt tttaacatct ataagaaata
    51841 agctcaaata acgttaaata cttgacctaa tcgctttttt tagatatgat aatatctgtt
    51901 aaagcattaa gcttactaat tatttggagg atttgttaaa tggctaacaa acaagattta
    51961 atcgcaaagg ttgcagaagc aactgaattg actaaaaaag attcagcagc agcagttgat
    52021 gccgtgtttt ctacaatcga agctttcctt gctgaaggtg aaaaagtaca attgatcggt
    52081 tttggtaact tcgaagtacg cgaacgtgca gctcgtaaag gtcgtaaccc acaaactggt
    52141 gcagaaattg aaattgcagc ttcaaaagtt ccagccttca aagctggtaa agctcttaaa
    52201 gacgctgtta aataattgca tatataaaag cccattgtac aagcgttgta gcctgtgcag
    52261 tgggcttttt tgtgttcagg ggggtaaaaa aggggtaaaa aatttaatag ttttccataa
    52321 tatcagctac acttgatttc attttctttg tgacatgagt ataaatttgg gcagtagttt
    52381 tagcgtctgc atgtcctaca cgttccatga ttgattttag cggcacgtta ttctctgcta
    52441 gacggctaat aagagtgtga cggaagatgt ggctagtaag tttttttgta attgggtctt
    52501 ccaatctttc attagctttt tttaaagcta agttgaatga gttagtctga attggaacac
    52561 cgttttttgt tgtaaaaagg tatcccatat ctctatatct atgatttgta tttttttcta
    52621 gttcgttcat aaattctaac tcttgtagaa tttcaagttc tctacttgtc atgatggttt
    52681 cacgataaga agctaatgtc tttggtgctg tcttttcccc gttacgatat ccttctgtat
    52741 gatcaaatgt tccgtgcaac tgcaatattc ttgacttaga ttcgtagttg cacggctcaa
    52801 tgctgacagc ttcaccgata cgacaaccgt tcaaactgat aaactcagcc aacaaaccaa
    52861 gtcggtaagt gctaggtctt ctgtacaatt ctttcaataa tggtttaatt tcatcttctt
    52921 caagatattt ttcttcagcc tttttccagt cttcaagagt tttctttacc cttgggagtt
    52981 tagcacgtct tgcaggatta tcttggataa tatccaaacc aacagcataa tcaaatgcta
    53041 agtttagcat agacttatta cgctcttttt tattcctaga gcaatctagg ttatcgagat
    53101 aattctgaac gtatttagga tcaatattca ctactttaac acctattcca aaagtttccc
    53161 ttatctcttc gatattacct ctcagagaag ctacagacga ccttttaagt tctttcttat
    53221 aaaacgccca ccattcatct aaaagttccg tgaaaagtaa ctcagaggcc tttaattgcg
    53281 ctattttttc tgttattttt tgttcaagga tttttcgagc tgctttataa gctcttgaat
    53341 tatccttctc catagtaacg gatacaggtt tccatgttcc agtgtaagga tctttataat
    53401 tttcacgaaa tttgaattta ccgttatcag tttcttctat ccacatttgt tttttacctc
    53461 attttctgtt aaaataggta tagtaaagag acctactgcg aagcaggttt ttactatact
    53521 agattcgcct cacgctctcc tcgccaaatt tgagcgtggg gcttttttgt tagttgagaa
    53581 accaagatgc tatcgactct aataatccag catttttact ttttgatact ctatctactt
    53641 ttaaaatagt caatcgtaac ttataagtta tatctttctt tttagtaacc acggtcttta
    53701 aatcgttttt gagtgttttg tattgtccac cacgaccagt aagggttgct tccatttggt
    53761 aatgactaga tttttttaca taaggggtta atcgtttagc taagtctgct ggaaagtagc
    53821 caacaaaagt tttgtttacc atgactttta tggcatttgg atcgtgacga ttaagaggtt
    53881 ctctgacaac ctctacatct tttgttgaga ccctgtaata cttgtagata tccttgaagt
    53941 ttgattttat gtagtcagaa ataaaatctt tatccttatc ccagtatggt gatttcttac
    54001 caatttcagc cataacttta ttagcttctt tttcatgata atttgttccc attaagagaa
    54061 agttatcttg gaatatgact tttgccataa cagtctcctt gggtgtgatg ttgtagttat
    54121 cgaagcatca tatgacctaa aatttattga tggcgaatca gtgccagagt taacaaaaga
    54181 gcaaaaagtt aaaagtatgg taaacggaat gtttgagcag gtttttggag gtgaatagag
    54241 atggcaaatc aattatcaac atacacacac aaacaatttt ttaacgcacc aacagttcaa
    54301 aaagcttttg atgacgtttg gaaaggcgcc gggacacagt tcgcggtaag catcttgtca
    54361 gtactacaag gtagtcaaag tttgaaatcg gcatctaata aatctattta tgcagcagct
    54421 atgaaagcag ccgtgttaaa tctgcctatt gagccaagct taggaagggc ctatttagtt
    54481 ccgtacaaag gtcaagcaca attccaatta ggctataaag ggttgattga gttagcgcag
    54541 cggacaatac aaaaatatta atgcaggtaa ttcgtttcaa aatccctaag ttgtttatga
    54601 catatgaaga agaaactttt aaagtaagac ttgagattga taaagtcgta aaaatattga
    54661 accaatacta aacaaaaaaa gccagctcac agctgaccat tggttaataa ttcgataaat
    54721 ctattatacc aaaaaggagt taggaagtga gcaaagctaa ggcaatttta tccctggttt
    54781 catggatgca gatgttatcc gtgatttaac gggagtaaaa ggggctgata aacctatacc
    54841 tgctatcacg gaggtaacaa ctgatggttg atgatgtctt acctaagcta ctaaaatctg
    54901 ttcgacaaga ttttgaaaag tattttggcg aaagtgatgt tgtaaccaag gcttttgcag
    54961 aattgcaagc taaaaaagtg acctataaaa cagtcaatga gtttgctatt gaagtcggaa
    55021 gacttttatc tttggctctg acaggttctg ttagctcgga taaattacca gacggtaaaa
    55081 tgtattacaa tatcgctaag cgtctcttag atgagactat gggacggaat tacaaattga
    55141 tttcaggtta tgctggtgat gttcagcgga ttttaaatga gaatgctcag attggtctaa
    55201 aggtgcaacg tccaccgcta aatcgagaca agattaacgg gatggtaaat cgtttggata
    55261 gcgagaatac atttgatgat gtaaaatggc tgtttggtga accgattgtt aatttttcgc
    55321 agtccattgt ggatgatacc atcaaggcaa atgcggattt acaatataaa acaggtatga
    55381 cgccacaggt tgtcagaaca gaaagtggca actgttgtga atggtgtcgt gaggttgttg
    55441 gcacttatag ttatccaaaa gtccctaagg acgtatggag aagacatcag cggtgtcgat
    55501 gtacgcttga ctatgacccg aagaatggaa aagttcagag tgcttggagt aaaatctggc
    55561 gaaagaaaga aaaaactcaa gaatctatag aaagggttga aaaatttaag gaaagtgctc
    55621 tagtagaatc tatcaaaaat gatatcgcta agttagatat gacaaaggtt ggtccgagtg
    55681 atataattga tatagggaaa cgtatcaatt atcactttag agtttcagaa catataggag
    55741 ataaagagaa attaaaagaa attttctcaa attttcgtga aatcggtgga gaaataccta
    55801 aaaatacttg ggcaaaaggt tcatctaaac ttgttaaaga ccagctacaa gaggcttttc
    55861 aaaattatcc aactgagtgg gcagctgttc cggacggtat tggtaaaaaa ctaaaagcta
    55921 taaaaaggaa gcgcggttac ttcgatggat atgatgaaga tttagttatt gctacaaatg
    55981 gaacaagaaa aacaacacct taccatgaga taggacatat gattgaactg gttaatcctg
    56041 atttagtaag attagagaaa gcctgggtag ataaaagaac tgctaatgaa gctgaggttc
    56101 gcttgaaaga tatttttcca agttcaaatt atggtattgg ggaagttact aagaaagatg
    56161 actttatatc accatatatt ggtaaatact acagcgatgc agctgaagtt ttcactatgg
    56221 gattacaagg tatttttgtt cctgaagaac gatttgctaa gtcctttgac aaaaaaacat
    56281 ggaaatatga ctacaagaca atcaatgacg accctgaatt tttgaatttt attattggat
    56341 tatttgtgaa agtgtgataa atatggaacc aaaattacat cggcaactgc gtcaaaaata
    56401 tgacgacgct gaaaaacaat atcttgaaaa gtttggagaa gactcgcttg atagagtatt
    56461 tttttgggag ccagacgttt actttgatga gtggaaaaag gttctaccag atgcaacact
    56521 ggaattaaac aaagctatta atagcggggt ggcgattgat ccagatccag aaaacgcaat
    56581 atattaagca cctagagcaa tctggtgctt ttcttatgct taaaaacagg aggaagacat
    56641 gaataaacgt atcaaaaaga aacgtaaatt ggaaacagcg gttgtgttat tgatcgcaga
    56701 aaacgcaaga caagcagaag caattaaaaa tcaaaacaaa caaatcatgg agctaaaatc
    56761 aatcgttcaa cgaaacgctc tggcaacaaa cgaagagtta gcgactgtta aagctgctac
    56821 tttagataac caatcagtta tcaaggcaat cggtgacacg gttgactaca tcaagaaaaa
    56881 ctacaaacgt aagtggggga agtgatatga aatatcgtaa gaaaccggtc gtagttgaag
    56941 caattcaatt tacgggtaca aactatgaaa aaatcaaaga gtttattggt taaaatacct
    57001 tatgttcgac tttgagtatt gtaatcccca ctcttgaagg cgacatggtc gctcaaaaaa
    57061 gcgactacat catcaaaggc atcgctggtg aattttattc atgtaaacct gatgtttttg
    57121 aacagactta tgaatcaact taaaccaaag tcgtagcaat acggcttttt attgtgccct
    57181 gtcgcatggc taaaaactag gcagtacgat tgaaaggaat aagtatggtt actaagacga
    57241 aaacaaagct tggcaatcag cgacctactc aatcggtaaa tttacatttt gctaaatctc
    57301 tagcgcatga agctattaat tactacaaaa aaacagggct aagctgctat ccatggcaag
    57361 aaaatatgct tataccaatt atggccgtcg atgaagatgg cttatgggtg catcaaaagt
    57421 atggatatgc tattccacgg cgtaatggta agacggaagt agtctatatt gttgagctgt
    57481 gggctttgca taaaggttta aaaatcctac atactgccca tcgcatcagc acatctcacg
    57541 catcatttga gaaggtgaaa aaataccttg agatgtcagg ttatgttgat ggagaagact
    57601 ttatatcaaa taaagccaag ggtcaagagc gtatagagtt caaagccagc ggcgctgtta
    57661 tccagttccg aactaggaca tcaaacggtg gacttggtga gggatttgac ttacttatca
    57721 ttgacgaggc acaagaatac acatctgagc aagaatcagc attgaagtac acagttactg
    57781 atagtgataa tccaatgact attatgtgtg gaacgccgcc aacgatggta tctactggta
    57841 cagtatttga agcatatcgg aaagattgct taaaaggcaa taagcgttat tctggttggg
    57901 ctgaatggtc agttcctgag atggttaaga ttaacgatgt atcttcctgg tatatttcca
    57961 acccatctat gggattccac ctcaacgaga ggaaaatcga agctgaatta ggtgaagatg
    58021 agattgatca caacatccaa cgcttaggtt attggccatc ctttaaccaa aaatcagtta
    58081 tatccgaaaa agaatgggca aaactcaaag ttgagcaagt gccagaactc aaaagcaagc
    58141 tttttgtcgg tatcaagttt ggtcaagatg gcaacaacgt atcactatca attgcagcaa
    58201 gaacatcaga aaataaggta tttgttgaga ctattgactg tttatcggtc agaaatggaa
    58261 ctcaatggat tattaatttt ttgaaatcgg ctgatatcgc taaggttgtc attgatggtg
    58321 caagtggtca agaattactt gctcaggaga tgaaagatca aggtctaaag aaaccagaat
    58381 tgcctaaagt tgctgaaatt atcacagcta acatgatgtg ggagcagggg atcatgcagg
    58441 aaaccatttg tcatagtgat cagccatctt tgacagcagt agtcacaaac tgtgaaaaga
    58501 ggcaaattgg ctctaatggt ggttttgggt ataaatcgct ttatgatgat agagacatta
    58561 gcttaatgga cagtgcattg cttgcgcact ggatttgtta cacaacgaag ccaaaaagaa
    58621 agcaaagaac cagctgttaa aaacgacatc cgaaagggtg tttttttact gctaaaaaat
    58681 ctaccgaact gccgggaaag caggagaaag gacgttaata tgtcagaatt taaagttatt
    58741 gaaacacaag aagagttgga cacgattgtg aaagctcgca ttgctcgaga acgtgagaaa
    58801 tatcaagatt acgaccaact gaaaactcgt gttgaagaac tagaaaccga aaacagcagc
    58861 ttacaaactg ctttgaatga tgctaaatca aacactgata gctatacgga agagattagc
    58921 accctgaaga atcaaattgc cgattatgag acggcaaatt tacggacaaa ggtagcgtta
    58981 cagtatggct taccaattga tttagctgat cgtttgcaag gagatgatga agatggactc
    59041 aaagtagatg cagaacgctt agcatcgttt attaagccat cccaaccaca accgccagca
    59101 aaatcaaacg aaccaaatat cgatagtaat gcagacgcaa attacagagc gttagtgcaa
    59161 ggattaagta cagaagatta gaagattaat taaaggagaa aaaatatggg aacagaaaca
    59221 tcaaaagcga gcttatttga caaacattta gtatcagatc ttatcaataa agttaagggg
    59281 catagctcac tagctaaact atctagccaa aaacctattc cgtttaacgg atctaaagaa
    59341 tttacgttta cattagattc tgatattgat gtggttgctg aaaacggtaa aaaaacacac
    59401 ggtggcttat cgctagagcc tgttactatc gtaccaatca aggttgagta tggtgctcgt
    59461 ctttctgatg aatttttata tgcaacagaa gaggaaaaga ttgatatttt gaaagctttt
    59521 aacgaagggt ttgcgaaaaa actcgctcgt ggtattgacc taatggcgat gcatggtatc
    59581 aatccacgta caaaaaaagc gtctgacgtt atcggcacaa atcactttga tagtaaagtg
    59641 acgcaagtgg ttaaatttac agagagcgaa gacgctgatg caaatatcga agcagctgtt
    59701 aatctaattc agggggctga aggtgtagtg acagggcttg cgatggatac agagttttca
    59761 acagcactgg cgaaagttac caatggggag atggggccta aaatgtaccc tgaacttgct
    59821 tggggagcgg atccagatag catcaatggc ttgaaatcgt ccgtcaatac tactgttggt
    59881 gctggagctg atgaagcaga atccaaagat ttagtaatta ttggcgattt tgaaagcatg
    59941 tttaagtggg gttatgcaaa acaaattcca atggaaatca ttaaatacgg tgatcctgat
    60001 aattcgggga aagaccttaa agggtataac caaatttact tacgtgctga ggcgtatatc
    60061 ggctggggta ttttggacgc taagagcttt gctcgtgtca ctaaaggaga agtataatgt
    60121 tatacgttaa cagtaagact ggagctagtt tttatagctc cgtccctgtt tgtggtggag
    60181 attggacttt ggttgaacag cagacaggcg aaaaagcaaa aacagtagca gaaattaaac
    60241 gtcagttaga tgctgctggg ataaaatata gctctaaagc taagaaacct gaattagagg
    60301 cactcttgcc tggttaggag gtaaaagtgg gcaattttgc aacaacagat gacgtcattt
    60361 tgttatggcg tcccttatct gttgacgaat tgaaacgtgc aaatgcactc ttgaaagtcg
    60421 tatcagatac attaagaatg gaagctgaca aagttggcaa agacttagat aaaacaatgg
    60481 ttgataagcc ttattttgtt aatgttatta aatcggttac ggttgacatt gtagctagaa
    60541 cactcatgac atctactcaa ggtgaaccga tgtcgcaaga aagtcaatcg gcacttggct
    60601 acacttggtc tggaacttat ttggttccag gagggggact gtttataaaa gacaatgagc
    60661 ttaaacggct tggtctaaaa aagcagaggt atggaggtat tgagctttat ggggaaatta
    60721 agagggataa cgattacttt gatagataaa gtaactatcg atatagaccc tttcggaaat
    60781 ccaataaaaa agataaagaa atatctgtcg ataatgtcct tgtatcgcca gcaacaagcg
    60841 atgacataac aagccagctt agcctttcag gaaaaaaagc tgtttacact ttagctattc
    60901 caaaaggaga caaccacgat tggggagata aggaagttag attctttgga gaaaagtggc
    60961 gcactgtcgg cctagctctt gaaggtattg aagagcttat tccgcttgaa tggaataaga
    61021 aagttatggt ggaaagatat gagtaagttt aaattcaagc tcaataaagc tggtgttgct
    61081 gaattgatga aatcatcaga aatgcagcag gtattaacca ctaaggccac agccatcaga
    61141 gaacgttgtg gtgatggtta cgcccaagat atccatgtcg ggaaaaatag ggctaatgct
    61201 atggtcagtg ctaaaaccat aaaggccaag aaagataatt caaaaaacaa cacattgttg
    61261 aaggcggtgc gatgattgat tgaagtaatt atcaaaaaat atttagacga gcacttagat
    61321 gtgccgtctt tttttgaaca tcaaaaagat gaacctgcac gattcatcat cttagaaaag
    61381 actagcgggg ttaagcaaaa tcatttgcta agttccacgt ttgcttttca aagttatgcc
    61441 gaatcgttgt atgaggcggc tttacttaat gacaaagtaa agcaagtaat tgagcagctt
    61501 gatgtcttgc cacaagtttc tggcgtacat cttaatgctg actacaattt tacagataca
    61561 gcaactaagc gctatcgcta tcaagctgta tttgatatta atcattatta aaggagatat
    61621 tgatgaataa gaatgatact aaaaatgtaa catctgcaaa gcccaagacc ggtggggcga
    61681 tttattcggc gccactcggc gctaaattgc cggaaaatgc aaccgatgat cttgatgacg
    61741 gatttaaaaa tcttggctat gtgtctgaag atggcgttac aaacgaagat acacgatcat
    61801 cagaaaacat caaagcttgg ggtggagata ttgttggggc tgtacagact gaaaaagaag
    61861 acacgtttac ttataagctg attgagtcac taaatgtgga ggttctcaag gaagtttatg
    61921 gggctaaaaa cgtaacggga gaccttgatg ctggtattca catcaagtca aactcaaaag
    61981 agttagaagc tcatgtaatt gttgttgaca tgattatgaa tggcggcatc cttaaacgaa
    62041 ttgtcttgcc aaatgcaaaa gttgatgaag taggtgaaat tgtctatgtc gatggcggag
    62101 tcgttggtta tgaaacaaca ctaaaatgtt tcccagatga aaatggggac actcaccacg
    62161 aatatattgt taagccaaag gcacaaaatc ttgaaatgta aggggtagtg aatggaaatc
    62221 ttaaaaggaa aaacaacatc aggatttgaa tacgaaatcc ctaaaaaacg attaaaaaac
    62281 tttgaacttg ttgaagctat tgcagaagag gaaactgatc caacagcagt agttaaaatc
    62341 gttaatttgt ttcttttgcg tctggcgagg attttgcaaa tgcacgtaaa caattactag
    62401 gaggtgatgg ctaatggcaa cagaacttgg tcaagcgtat gtgcaaatta tgccatccgc
    62461 tcgtggaata agtggagcaa tctcgaagca acttgatccc gaagcaaggt cggctggttt
    62521 gagcgctggt tcgctcattg gtggtaatct cgttaaaatg attggtggtg ccattgcagc
    62581 tgctggaatc ggtaagatga tttcgtctgc cttgtccgct ggtgctgatt tgcagcaatc
    62641 ttttggtggt attgacacat tgtataaggg cgctgagact gctgtcaaag ggtttgctaa
    62701 agaggcatac aaagctggaa tatcagcaaa tacttatgca gagcaagcag tttcaatggg
    62761 tgcatctcta aagcaatcac ttggaggtga tgctgtcgcg gctgccaagg ctgctaacat
    62821 ggcaatcatg gatatggccg acaactcggc taagatgggt actgatatca catcaatcca
    62881 aatggcttac cagggatttg ctaagcaaaa ctatacaatg cttgataacc taagacttgg
    62941 gtacggcggc acaaaagaag agatgaagcg tcttttatca gacgctgaaa agttacctgc
    63001 cgctatgggc aagaagtttg atttgagtaa ttatgctgat gtggttgagg ctatacactt
    63061 ggtacaggat aacatgggta tcgctggagt tgctgctgaa gaagcaaaaa ctacattttc
    63121 aggctcacta gctgctatga agtcttcttt tacaaatgta ctggcaggtt tatcactagg
    63181 agatgatata agacctgctt tacgaggact ggctgaaaca acttctaatt tcttatttgg
    63241 taactttatt ccgatggtgg caaatatctt taaaggatta ccatcggcaa ttggtacttt
    63301 tattggagca gcaactccta ttattgccag tcaatttaaa gggctaatga gtagccttgg
    63361 gattagtatt gatttaagtc ctattactgc taaatttgcg cagattggtc aaaacttaca
    63421 acctgttttt gatggtttaa aaaccgcttt tgggcagttg ccatcatttt ttactagcat
    63481 cggtgatgca gttgcaccag tgatagacac tattatcagc ggattagcta gattagactt
    63541 tagtggtttt gaggctttga tttcagcaat cttaccagca attcaaacag ggttccaaac
    63601 gttcatgtct attgtaggtc cagcgattag tcagcttgta aatagttttg ttaatctttg
    63661 gaatgcttgc caacctctag taacaatatt aagtagcgca ttgatgccag cttttcaaat
    63721 tttaggagct tttctcggcg gagtcttaca aggaatcctt ggcagtatta gctttgcatt
    63781 tgatgcttta aaagttgtta ttgagttttt aacgccaatt attgattggc ttgtacaagg
    63841 ttttaatgct atttcaccgg cattacaaac cgttgcccag tgggttggta atgtcattgg
    63901 tatatttact agcttaggtg catctgggca aggtttaagt agtatgctaa gcagtgcttg
    63961 ggggaacatc caaacagtag tttcgacagc taaaaatatg ataactttgg cgattgatgg
    64021 tattaaattg gtatttagca atctagggaa tgctggaaat attttaaaag gattactttc
    64081 ggcagcgtgg tcagctatgc aaaatgcagt agtgatagct aaaggtatta tcaacagtgc
    64141 gataagcgct ataaaaacag catttagcag ctttggtaat cttgtatcta gcgtaagtgg
    64201 aactataaaa tctgttattg gcagtttaaa aaatgcgttt tacagtttag caagtattga
    64261 cttagttggt gcaggacgtg caatcatgca aggatttcta aatggactaa aatcgatgtg
    64321 gggggcaatc accggctttg ttgggggtat tgctgactgg atccgtaagc acaaagggcc
    64381 tatctcatac gatagggttt tgctaaaacc cgcaggtaaa gtaatcatgc aagggttcaa
    64441 caatagcttg atggatggct ttaaagaggt taaatcaaat gtatctggca tggctgacga
    64501 tcttgcaggc accataacag gtaaaagtct atctctcggt atcgatgcta aaccaagcgt
    64561 cacagctgat gacttactat caagcaatat tagtactaaa actacagtcg gttctgctac
    64621 aagtgacttg tcattatttt ttgttaaggt gcttgctctg ttgcaagata tccttgataa
    64681 aaatacggat gtctatctag acaaagaaaa agtcagcgct attttatacg aagaatttgc
    64741 caaaatcatg gctagagagg ggattgcatg ataccaaagg ttattattga tggttttgat
    64801 acctctacaa tccctaattg tgtcctaact ggttatgatg taggggatgt tttatcccct
    64861 cattttgtcg aaaatgaagt gtatgggatg aatggtacta gtaggggatt agagtcatac
    64921 aatgagtcga aacccactct aacatggcat ttgagcactt ttgatgatgc agttaattta
    64981 gtgaatcatt tagatggact tgggaaaatc attgaatttt ggcatattcc gaagtcattt
    65041 tattattatg attgcctatc tgtcaaaatc aatgcggtaa ctatgaactc gtggagagtc
    65101 acacttaaac ttgcactata tccatttagg tatgcgaaag gtatctcaga tgtaacgatt
    65161 gcaggcaatg gaagtataaa taatccagga aatgttttta gtgaacctaa gataattgtt
    65221 gagggtaccg gcaaaggaac actaaccatt gacaaacagg tcatggaatt aaatttgtca
    65281 ggtaaagcaa cgattgagtg caaacatggc caacaatgcg tttatgatgg tgaaggtaat
    65341 gtgaaaaact caatccgaat aagaggaaga ttttttgaaa tacaacctgg cacacaaggt
    65401 attgccgtaa gcggaggcat tgccaggtta acaattagtc caaggtggag gtacaaggtt
    65461 tgatatcgat taaagatgat aatacacctc ttgtagcagc ctttgaagat gagattacac
    65521 aggaagcgaa tagcgattat aaattaagtt ttaagtatcc agctaaacat gagtatcgcc
    65581 ccttgatcaa aaaaggaata atcctagaag ctgatgacct acatggaact cagcttttta
    65641 gggtttttga gattactaag cgacatggct atatcaatgt ttatggtaat caggtcgccg
    65701 atgatttaaa tggctatgca attgactcta tcagtgttga tagggtgcaa ggtatgacag
    65761 taatgtcaga gttagcaggt aatatcaagc gtaagcatcc ttttagcttt tttagtgata
    65821 ttgacggtcg tcacacattt aatcaatcag acgtatctgt tatggacgct ttagctaatg
    65881 gcaagcactc aatcatgggg cagtggggtg gcgagcttgt acgtgataag tatcaggtta
    65941 atttgctcaa aaaagctggt aaagacattg agaccttatt tatgtataag aaaaacctca
    66001 aatcttatga ggaaacagat actatcaaag ggcttgtctc tatccttcat ttagttgctg
    66061 aagtagaaga agaacatgaa gtagaaacca gagaaacttc agatggaaac attggtcata
    66121 gtgaatcacc gaaaaagaaa actattaggg tatctgttga gagcaagctc aaagacactc
    66181 atccgataat tgttgaaaag actatcaagg tgcaggatca agatgtcaaa acagaagagg
    66241 acttgcttgc atatggtaag aaatactttg aaaaaactct ttgcgatata ccaggtaata
    66301 gtttaaaaat tgatgttact aataactacg agggcgctgt taggctattt gacacagcaa
    66361 ttgtcttcca cgagctctat gacagagact tacgaatgca aatcactggc tatcggttcg
    66421 cccctatggc taatcggtta aaatccatca tctttggaga gattaagacc aacttagcaa
    66481 aacaaattag caatcaaatt gacaataagg tagctgaatc aactgctcaa catgacgcag
    66541 tatttgaagc aaaattacaa aagcagattg ataatgctaa tcgtattttt gacacaaaag
    66601 aagctaaact ccgtgaagag attgaagatg gcatcaaaaa agctgaagct aatgctgagg
    66661 tcaaagttgc tgaggttaac gctaaagtgc tagaagctga ggagctagcc aaggcagtcg
    66721 atgagcggct caaaaaattt ttatctgatg ctgacactaa agagcaagat tttgataaaa
    66781 aacttgaaga atttagaacg tctcttaaag accttgaagt tgatgaaaag cagattgatg
    66841 atgctttggc caaagccggt tttagcaagg atagcttagc tgacattaaa gctaaactgg
    66901 aagacacgtc tgaaactgcc acagttacag ctaacattgt tggatcaact ggcggcacgt
    66961 tttacaatcg caacagactg gatggtgata ctgacaaagt tatcactttt gaacaaggtt
    67021 atattgacat tgcccataat ggtgaaggtt ttgaagaagg caagacatac actatcagct
    67081 ttgaggcaac ctgcgagcta ctgcgtaaag taggaatcac agtgacacag gctaacatga
    67141 aaggtgctcg cttagtgtta acacctaaaa atcccaaatt agttgtcgag agttttggct
    67201 tgactaagga tactgagact atcaatgtct atccgtttag ctacacagtg cttgtaacca
    67261 gcgactggta taaatctaag caaatagatt taaacgcctc agacacgcag gaattggctc
    67321 tagagatgga ttataaagat gttgttgacg gcaaggatgc cacaataaca ggggcatggt
    67381 cagacagtcc acaaataatt ttatacggag gtaaaaaatg acagaaacta taccattaag
    67441 agtccaattt aagcggatga aagccgccga gtgggcaagt agtgatgtcg tcttactgga
    67501 gggtgagatt ggctttgaga ctgacactgg ttttgctaag tttggcgatg gtcaaaacac
    67561 ttttagtaag cttaagtacc ttactggtcc caaaggtcct aaaggagaca ctggtatcca
    67621 aggtaaaact ggaggaactg gtcctcgggg ccctgctggc aagcctggaa cgacagatta
    67681 tgatcaactc caaaataaac cagatctagg tgcgtttgca caaaaagaag aaactaatag
    67741 taaaatcacc aaattagaat caagcaaagc agataaaagc gctgtttact caaaagcaga
    67801 gtcaaaaata gagctagaca aaaaattgag cttaacaggc ggcatagtga caggacaact
    67861 acagtttaaa cctaataaaa gtggtattaa accctcatct tccgtaggag gagcgattaa
    67921 cattgatatg tctaaatcgg aaggtgctgc tatggtgatg tatacaaata aagatactac
    67981 tgatggacca ttgatgattt tacgttctga caaagatacg tttgatcagt cagctcaatt
    68041 tgtggattac agcggtaaga ctaatgctgt aaatattgta atgcgccagc caagcgcacc
    68101 taatttttcc tcggcactta atataaccag tgccaacgaa ggcggtagtg cgatgcaaat
    68161 tagaggcgtc gaaaaagcgc taggaacgct caaaatcaca cacgaaaacc caaacgttga
    68221 ggcaaaatac gatgaaaacg ctgcagcgtt atctattgat atcgttaaaa aacagaaagg
    68281 cggaaaaggt actgctgctc aaggaatcta cattaactca acatcaggca cagctggtaa
    68341 aatgctcaga atcagaaata aaaatgaaga caaattttat gtaggtccag atggcggctt
    68401 tcactcaggt gcaaattcaa ctgtagctgg taatctaaca gttaactatc caacatctga
    68461 aaaacatgct gcgactaaaa aatacgtaga tgaaaaaatt gctgagttaa aaaaactcat
    68521 actaaaaaaa tagattaagg aggataaatg agcagagacc caacatatac aataaacgag
    68581 cacgacttat cttttgcaga tggtcgtttt tatgtgacct ttaaggcaga taagtcaagt
    68641 gagactgtga gacttaacag tagttgcctt ggcaatacca taatcaaaaa gctacaggtc
    68701 gaggatgaca atacaatgca cgactttgta aagcctaaag ttaccactca acaagctttt
    68761 ggactagctc agcaggtcaa agagcttgat ttacagctaa aagaccctaa gtcagatttg
    68821 tggggcaaaa tcaagttcaa taataaggca atgctagtcg agtacgccaa caaagagatg
    68881 tcaagtgcca ttgcgcaatc agctgagcag atattgttac aagtcaagtc tattgatgat
    68941 gaacgatatt ccaaatttga gcaaactctg aatggtatca aacaaactgt caaaagtgag
    69001 tcagttgaat ccgcacgtac tcagctagca tcaatgtttg atagtcgtat tagtggactt
    69061 gatggcaaat acagtcgttt aagccaaaca attgatagtc ttagcagtcg tcttgatgat
    69121 ggtgttggta actactcaac gctatctcaa aaggtaagtg gcattgattt acgagttagt
    69181 aatgcagcta atgatgtttc tcgattgtct cagacagcac aaggattgca gtcacaaatc
    69241 acaaatgcaa accaaaatta cagcagtttg tctcagactg tagggggtct acaaacaact
    69301 gtacatgata atcaatcaaa tgctacaagt cggattaatc aattaagtga tttaatcagt
    69361 actaaagtga ctaagggcga cgtcgaaaca actattgctc aaagttacga caagatagcc
    69421 ttcgcaatca gggataaact cccagcaagc aagatgactg gcagtgagat tatctcggca
    69481 atcaatcttg ataggtctgg ggttaaaatc actggcaaaa acatcacatt agacggtaac
    69541 agctacatca gcaacgctgt tatcaaagat gctcacattg ctaacatgga tgctggtaag
    69601 attaacactg gttatcttaa tgctagtaga attgcggcag aagctatcac tggcgacaaa
    69661 atcaagatgg actatgcttt ttttaataag ctcactgcta atgagggata ttttaggacc
    69721 ttatttgcta aaaatatctt taccacatct gtacaggctg tcactacgtc tgcgagtaag
    69781 attacaggtg gtgtgctttc tgccacgaat ggtgcgagta ggtgggattt gaatagtgca
    69841 aatattgatt ttaatcgaga tgccacaatt aattttaaca gcaaaaacaa tgcgcttgtt
    69901 cgaaaatcag gtacccacac tgcttttgta cattttagta atgcgacacc aaaaggctat
    69961 agaggctcag cgttgtatgc gtcaatcggg ataacctcat caggagatgg catcgacagc
    70021 gcttcgtctg gacgtttctg tggagttagg tttttccggt acgctgaagg gttacagcat
    70081 acagcaaagg tcgatcaagc cgaaatttat ggtgatgata ttgtctttag cgacgatttt
    70141 aacatcgatc gtggctttaa gatgcggcct agcctaatgc caaaaatggt cgacttaaac
    70201 aagatgtacc aggcaatttt ggctctcggc cgctgctggc tgcatgctaa taacacggct
    70261 tggtcgtgga attttgatac acgcagcgca atcatcgcag aatataacgc acacattaat
    70321 aacttatagg agaaacaatg gatttaacgc ttaaaaacaa agatttaaac acactatata
    70381 gtgtactaga caaaatcaaa atcacgaaca tgcgagcaaa ccgcggacgt gctaagctac
    70441 tcgcaaaagt agtagataaa ttcaaagagt acgccaagga tgagggtgac cttattgatc
    70501 tgtatgctca aaaagacaaa gatggcaagt ttgtcattga tgagcacaaa aacatcaagc
    70561 tagcagaccc cgctaaactc gacgagttca acggcctact caacgagcta gctgatgaag
    70621 aaattgtgat taaagggggt gagtactcca agcgatttat cgattttttg gaatatttag
    70681 ccgaatctga agatgagttt acagctcaag aaatcattat tgttgacagc atcttagagc
    70741 aatacgaagg aagcaaagga gaataactat gaagacatta acactatcag gcaaacctta
    70801 tccaattcat gaaggcggta aagttgtaaa aacagaggtt cgcttaatcg gtgacaatgg
    70861 gctatttatc cccattgaat taatcggtga tcagacagct aagggagcag atgaccttat
    70921 taaagagggg ctagatgctt ttgtacgcga gtatgtgact aaatacgccg tagcagaatc
    70981 agtgcaaaaa gtggaagagt tgagcctcgc acaaaaagag attgagcaaa atgcggagca
    71041 agcaaaggta acagcagaag ccgctgaaaa acaagctaaa tctctggagc ttgtcattgc
    71101 aaaatctcaa aaaatggcta atctacaagc aatccatcta ctaacaagcg gaagcaaagt
    71161 ggaacccgat atttacaaag gtcttttaga gctaatcgag ccagccaaac aaggtgagta
    71221 tcaagcctat gatgtcttta cggtagtaga cgagtcgcac gaagagcagg caggagaagg
    71281 taatcttgtc tttgtacacg ttaacgagcc atttacttat gacaaacaga cgcttaaaga
    71341 gctagaggaa gaggataaag tcacagtcat taagtatgcg gacttagtta agcaggatta
    71401 gcgaggtaag ttatggcaac agagttgata tttggcctcg gcggctttat tttagctatc
    71461 gtcacgactt acaatatttt taatgcaaaa tccatcaagc atgcgacaga tattactttg
    71521 ttgcagtctg aggtagagca tttaaaaatt gtcactcggc aaaatgctag gcgtcttgag
    71581 gagcatgatg agcaaaacaa aacgctcatc acaatgacag agcaaattaa aaacctcaat
    71641 cgtgaggtaa gagaacttaa agatattatg agaggcgaag catgattaat ttaaaattac
    71701 gactacaaaa caaagtaacc ttgatggcta ttttaggagc tatcttttta ctggcacagc
    71761 aattaggtat taaactacca tcaaacatcg cggatattgc aaacacagct gtaacgcttt
    71821 tggtattgct cggtgttgtc acagatccaa ccacgaaagg cctgtcagac agtgagcaag
    71881 ctttgactta ccacgaacca aaacaatagg aggggacatg cgggcaatca cacgattagc
    71941 attagttata gcaatagcaa tactgtatgt gccattatct gttgttgctc tgatctttta
    72001 tccattttta gataaggagg atgatagatg gtagtagata ccgaaaaagc tatcgcttgg
    72061 atgggtttaa aaaagggtcg tgtcagctat tccatggact gccgtaatgg tcctgatagc
    72121 tatgactgct caagcgctat ttgtagtgct ttaatctatg caggagctag taatcctggt
    72181 tggctactca atacagagta tatgcacgac tggctagtcc aaaacggctt tgagttaatc
    72241 gctgataatg aggattggga tagccaacgg gctgacattg ctatctgggg attccgtggg
    72301 caatcagcag gcgcgggtgg tcacgttgtg atgtttattg atgctgacaa tattatccac
    72361 tgcaattacg caaataataa catcacgatt gataactaca atcaaacagc agcagcgagc
    72421 ggttggatgt actcttatgt ttatcgctat acaggagcaa aagcccaacc tgctacaaat
    72481 aaaagcattg atgagctagt tcaagaggtc ctatctggca aacatggtag tggcgagcag
    72541 cgcaaaatct cacttggtac taactatgat gccgttcaag caaaagtaaa cgagatgctc
    72601 aaacaaccac aagtagcgga gcaaagccct gctgtcaaac aagacggaga cttattgttt
    72661 aatggtgctg tgcttaaaaa gacagtcttg gataaaatcc tagctaaatg taaagagcat
    72721 gacatcttgc caagttatgc cattactgtg ttgcattttg aggggctttg ggggcaatct
    72781 gctgtaggcc gtactgacaa caattgggga ggtatgacgt ggactggcca aggcaaccgt
    72841 ccaagcggca taacggtaac gcaaggtacg gaaaggcctg ctgttgaggg tggtcattac
    72901 atgcattatg ctagcgttga cgactttttg acggactggt tttatctctt gagagctgat
    72961 ggctcttata gggtaagcgg tgctaagact ttcagcgagg ctgtgaaagg catgtttaag
    73021 gttggtggtg caacctatga ttatgctgca agcggatttg atagctacat tgttggtatg
    73081 gctggcaggc taaaagcaat tgagcaggaa aacgggtcac ttgccaagta cgaccaacag
    73141 gccgacattg atgtcggtca gtctgataaa attgacgttg ttattgacag cttggaaatt
    73201 accatcaacg gtgtgactta caccgcaact aaaaaaccaa tttaggaggt aaagctccga
    73261 gataagacaa aaccgctcag attattcttg ggcggttttt tattatattt tatcttgttt
    73321 tttgaaataa aaacaaatat aatatataaa aacgcaaaaa atatcttaag gagtaggatt
    73381 atggcattac agggaataaa aaagttacca gtcttgctag aggataagca agccttaagc
    73441 ctttataaga aactggcaat agtaaataag gttctgggga agttagatgc tgttttagaa
    73501 tcatccatta ttaactcttc gattctcagt ttattatctt acaatgagtc agtacaatcg
    73561 acaagaatag aagggactca agtaactttc catgaaataa tggagactgc taaagtaggt
    73621 gccaaaaatt ggcagcaacg agaagttttt aattataaaa aggcgattga ttttggtttt
    73681 cataaaataa aaaaaggcga tgtcataact acacggttga taaaagatct ccatcgcctt
    73741 ttgatgtctg atgaagctag aggaactaca tctaacggcg gagagtttag gaagattcaa
    73801 aattttattg gtccagataa ggatatcgaa aatgcttcgt atatccccat tcccgcaaac
    73861 gaaattggtg catttatgac aaatctcgaa ttttttataa atggggaata tcattcgagt
    73921 ttagagtgcg ggaggactca agaatctatt aactttaata gtgatatttt attgagaatt
    73981 gcggttgctc atgcgcaatt cgaatcaatt catcccttct tagatggtaa cggccgtctt
    74041 gggagaattc ttattgcatt gatgtctgtt caggaggggc ttctaaaaca cccaatattt
    74101 ttcgttagtg aagaattaga aaaggaaaga attcgttatt ataacgcgct taatgctaca
    74161 aggggagaga atccagattg gaacttatgg cttaatctct ttctcaatgc tagtgagcaa
    74221 atggccaaga atatcttaaa gaaaattcga aatgcggatg aacatgccaa aaaaggactt
    74281 tctgtttgtg tgactcaaac tcaaaaaaca gtttggcttg ctacttttag ttttcctgta
    74341 tcaactgcaa aacagttagc cgaggctacg gagttccatc cagcaacagt gaaaaaagct
    74401 ttggacttct tggtaggaga gggattgttg gataaagata attcagtaaa acgaaatgtt
    74461 ccgtattaca actatgattt aattcgtgcg atacaaaatt attaatatac agacactttt
    74521 acctctatac tgatccccct gcacattcat aggataatca cactagcaag aatcgcctga
    74581 cattagcggc tcttgctttt ttatttcaat tttatctctt ttaaaattaa aacattgatt
    74641 taattttatt atagattttt aat
//
LOCUS       DAUDWO010000002        72728 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.002, whole genome shotgun sequence.
ACCESSION   DAUDWO010000002 DAUDWO010000000
VERSION     DAUDWO010000002.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 72728)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 72728)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..72728
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.002"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            222..1505
                     /locus_tag="VHC05_000080"
     CDS             222..1505
                     /locus_tag="VHC05_000080"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017645628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor"
                     /protein_id="HEQ5401431.1"
                     /translation="MSTSFENKATNRGVITFTISQDKIKPALDKAFNKIKKDLNAPGF
                     RKGHMPRPVFNQKFGEEVLYEDALNIVLPEAYEAAVTELGLDVVAQPKIDVVSMEKGK
                     EWTLSAEVVTKPEVKLGDYKNLVVEVDASKEVSDEDVDAKIERERQNLAELIIKDGEA
                     AQGDTVVIDFVGSVDGVEFDGGKGDNFSLELGSGQFIPGFEDQLVGAKAGDEVEVNVT
                     FPESYQAEDLAGKAAKFMTTIHEVKTKEVPELDDELAKDIDEDVDTLEDLKVKYRKEL
                     EAAQETAYDDAVEGAAIELAVANAEIVDLPEEMIHEEVNRSVNEFMGNMQRQGISPEM
                     YFQLTGTTQEDLHNQYSAEADKRVKTNLVIEAIAKAEGFEATDSEIEQEINDLATEYN
                     MPADQVRSLLSADMLKHDIAMKKAVEVITSTASVK"
     gene            1722..2297
                     /locus_tag="VHC05_000081"
     CDS             1722..2297
                     /locus_tag="VHC05_000081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit delta"
                     /protein_id="HEQ5401432.1"
                     /translation="MKLDVFAGQEKSELSMIEVARAILEERGRDNEMYFSDLVNEIQN
                     YLGKSDAGIRHALPFFYTDLNTDGSFIPLGENKWGLRSWYAIDEIDEEIITLEEDEDG
                     AQKRKKKRVNAFMDGDEDAIDYRDDDPEDEDFTEESAEVEYDEEDPDDEKSEVESYDS
                     ELNEIIPEDDFEEVDINEEDEEDEEDEEPVL"
     gene            2554..4158
                     /locus_tag="VHC05_000082"
     CDS             2554..4158
                     /locus_tag="VHC05_000082"
                     /EC_number="6.3.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982843.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CTP synthase"
                     /protein_id="HEQ5401433.1"
                     /translation="MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYI
                     NIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKE
                     RKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQ
                     MKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVE
                     QGIKNKLAQFCDVNSEAVIESRDVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTE
                     WSAMVDKVMNLRKTTKIALVGKYVELPDAYLSVVEALKHSGYANDTAIDLKWVNANDV
                     TVDNAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFA
                     RHVLNMEGANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAY
                     NNQEVVQRRHRHRYEFNNKFRSEFEAAGFVFSGVSPDNRLVEIVELKEKKFFVAAQYH
                     PELQSRPNRPEELYTAFVTAAIKNSN"
     gene            4326..5252
                     /locus_tag="VHC05_000083"
     CDS             4326..5252
                     /locus_tag="VHC05_000083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEQ5401434.1"
                     /translation="MKTIRIAKYLGILFLLITLISVGASFYFFHVAQIREEKSFINNK
                     KRSTNNPLYPAEQSFDALPYEKRQLTNRGLKQVGWYLPAAQKTKKTAIVVHGFTNDKE
                     DMKPYAMLFHDLGYNVLMPDNEAHGESEGNLIGYGWNDRLNVMAWTDQLIKENPESQI
                     TLFGLSMGAATVMMASGERLPAQVTSLIEDCGYTSVWDELKFQAKAMYNLPAFPLLYE
                     VSALSKIRAGFSYGEASSVKQLAKNKRPTLFIHGDKDDFVPTKMVYDNYKATKGPKEI
                     LIVKGAKHAKSFETNPEQYQKKIAAFLKKVEK"
     gene            5306..5391
                     /locus_tag="VHC05_000084"
     tRNA            5306..5391
                     /locus_tag="VHC05_000084"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:5340..5342,aa:Leu,seq:aag)
     gene            5597..6478
                     /locus_tag="VHC05_000085"
     CDS             5597..6478
                     /locus_tag="VHC05_000085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-bisphosphate aldolase"
                     /protein_id="HEQ5401435.1"
                     /translation="MAIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAP
                     VLIQTSMGAAKYMGGYKVCQSLITNLVESMGITVPVAIHLDHGHYEDALECIEVGYTS
                     IMFDGSHLPVEENLAKTAEVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAK
                     AMVETGIDFLAAGIGNIHGPYPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQI
                     KEAIRLGVAKVNVNTESQIAFSNATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAV
                     QGAVEERIDVFGSANKA"
     gene            6860..7048
                     /locus_tag="VHC05_000086"
     CDS             6860..7048
                     /locus_tag="VHC05_000086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008536053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="HEQ5401436.1"
                     /translation="MAKVCYFTGRKTVSGNNRSHAMNQTKRTVKPNLQKVTILVDGKP
                     KKVWASARALKSGKVERI"
     gene            7200..7565
                     /locus_tag="VHC05_000087"
     CDS             7200..7565
                     /locus_tag="VHC05_000087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEQ5401437.1"
                     /translation="MTVKINTKDGLIELSDDVIATVVGGSATEIFGVVGMASKSAIKD
                     NFQSLLRKENYAKGVVVKSTDLGISVDVYTVMSYGVKISEVSKNIQERVKFNLESQLG
                     LTADMVNVYVQNIKVVGEN"
     gene            7565..9229
                     /locus_tag="VHC05_000088"
     CDS             7565..9229
                     /locus_tag="VHC05_000088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DAK2 domain-containing protein"
                     /protein_id="HEQ5401438.1"
                     /translation="MSNITTSLFQEMVQAAATRLGKQAEYVNSLNVFPVPDGDTGTNM
                     SMTMDNGAKEVADKPASTVGEVGQMLSKGLLMGARGNSGVITSQLFRGFGQSIKGKDE
                     LTGKDLAQAFQVGVEVAYKAVMKPVEGTILTVSRGAATAALKKADLTDDAVEVMQAAL
                     DGAKGALAKTPDLLPVLKEVGVVDSGGQGLVFIYEGFLSALNGDYVTSADFKATPANM
                     SEMINAEHHKSVVGHVATEDITYGYCTEIMVALKQGPTYVKEFNYDEFQGYLSGLGDS
                     LLVVNDDEIVKVHVHTEDPGLVMQEGLKYGSLIKIKVDNMRNQHEAQVQKTDVEKNKA
                     EVKDFGLIAVVAGEGLSEIFKAQGVDYVISGGQTMNPSTEDIVKAIEAVNAKQVIILP
                     NNKNIFMAAQSAAEVVDIPAAVVATRTVPQGFTSLLAFDPSKSLEDNVADMSTSLSDV
                     VSGSVTLAVRDTTIDGLEIHENDFLGMVDGKIIVSNPDMEATLKAAFEKMIDEDSEIV
                     TIFVGEEGDQDLAEELAGYLGETYEDVEVEIHQGDQPVYPYLMSVE"
     gene            9466..10356
                     /locus_tag="VHC05_000089"
     CDS             9466..10356
                     /locus_tag="VHC05_000089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HEQ5401439.1"
                     /translation="MLEPFIFIAFGVIIILAIVASTLYVVRQQSVAIVERFGRYQKTA
                     TSGIHIRLPFGIDKIAARVQLRLLQSEIIVETKTKDNVFVTLNVATQYRVNEQNVTDA
                     YYKLMKPESQIKSYIEDALRSSVPKLTLDELFEKKDEIALEVQHQVAEEMSTYGYIIV
                     KTLITKVEPDAEVKQSMNEINAAQRKRVAAQELANADKIKIVTAAEAEAEKDRLHGVG
                     IAQQRKAIVDGLAESIQELKEANISLNEEQIMSILLTNQYLDTLNTFAAKGNQTLFLP
                     NTPSGVEDIRTQVLSALKTK"
     gene            10586..11440
                     /locus_tag="VHC05_000090"
     CDS             10586..11440
                     /locus_tag="VHC05_000090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5'-nucleotidase, lipoprotein e(P4) family"
                     /protein_id="HEQ5401440.1"
                     /translation="MKSKKVVSVISLTLSLFLVTGCAKVDNNKSVNRKPATKQTYNSY
                     SDDQLRSRENTMSVLWYQRAAETQALYLQGYQLATDRLKEQLNKPTDKPYSIVLDIDE
                     TVLDNSPYQAKNVLEGTGFTPESWDYWVQKKEAKPVAGAKDFLQFADQNGVQIYYISD
                     RSTTQVDATMENLQKEGIPVQGRDHLLFLEKGVKSKESRRQKVKETTNVTMLFGDNLL
                     DFADFSKKSQEDRTALLSDLQEEFGRRFIIFPNPMYGSWEGAIYKGEKLDVLKQLEER
                     RKSLKSFK"
     gene            11633..12829
                     /locus_tag="VHC05_000091"
     CDS             11633..12829
                     /locus_tag="VHC05_000091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate kinase"
                     /protein_id="HEQ5401441.1"
                     /translation="MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTI
                     KYIIEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVVFPGVTRGSKLEE
                     AINALEDGQVLLVENTRFEDVDGKKESKNDEELGKYWASLGDGIFVNDAFGTAHRAHA
                     SNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEK
                     ADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKDLLEKSNGKLILPVDSKEANAF
                     AGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAG
                     TIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGL
                     AALTEK"
     gene            13092..13643
                     /locus_tag="VHC05_000092"
     CDS             13092..13643
                     /locus_tag="VHC05_000092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011527757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HEQ5401442.1"
                     /translation="MKTLRKLLSNYKFDIKKFKLGMRTLKTGLSVFLVLLVFHLFGWK
                     GLQIGALTAVFSLREDFDKSVHFGFSRIIGNSIGGLLSLVFFAFNEIFHQAFWVTLLI
                     VPICTMLCIMVNVACNNKSGIIGAVAALLIITLSIPTGQTFIYVTSRVFETFCGVFVA
                     ILVNTDVELIKNKWFNKKHSDVR"
     gene            13710..14081
                     /locus_tag="VHC05_000093"
     CDS             13710..14081
                     /locus_tag="VHC05_000093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003058022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HEQ5401443.1"
                     /translation="MKEKELRRSMAVFPIGTVMTLTDLSARQIRYYEDQGLIKPERTQ
                     GNRRMFSLNDMDRLLEIKDFLSEGLNIAAIKREYVERQGKLMQKQKALTDADVRRILH
                     DEMLTQSGFSTPSQHIGNFRI"
     gene            14119..15465
                     /gene="glnA"
                     /locus_tag="VHC05_000094"
     CDS             14119..15465
                     /gene="glnA"
                     /locus_tag="VHC05_000094"
                     /EC_number="6.3.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="HEQ5401444.1"
                     /translation="MAITVADIRHEVKEKNVTFLRLMFTDIMGVMKNVEIPATKEQLD
                     KVLSNKVMFDGSSIEGFVRINESDMYLYPDLDTWIVFPWGDENGAVAGLICDIYTAEG
                     KPFAGDPRGNLKRALKHMNEIGYKSFNLGPEPEFFLFKMDDKGNPTLEVNDNGGYFDL
                     APIDLADNTRREIVNILTKMGFEVEASHHEVAVGQHEIDFKYADVLKACDNIQIFKLV
                     VKTIAREHGLYATFMAKPKFGIAGSGMHCNMSLFDNQGNNAFYDETDKRGMQLSEDAY
                     YFLGGLMKHAYNYTAITNPTVNSYKRLVPGYEAPVYVAWAGSNRSPLIRVPASRGMGT
                     RLELRSVDPTANPYLALAVLLEAGLDGIINKIEAPEPVEANIYTMTMEERNEAGIIDL
                     PSTLHNALKALQKDDVVQKALGYHIYTNFLEAKRIEWSSYATFVSQWEIDHYIHNY"
     gene            complement(15693..17375)
                     /locus_tag="VHC05_000095"
     CDS             complement(15693..17375)
                     /locus_tag="VHC05_000095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HEQ5401445.1"
                     /translation="MTNISLKPNEVGVFAIGGLGEIGKNTYGIEYQDEIIIVDAGIKF
                     PEDDLLGIDYVIPDYSYIVDNLDRVKALVITHGHEDHIGGIPFLLKQANIPIYAGPLA
                     LALIRGKLEEHGLWREATVYEINHNTELTFKNMSVTFFKTTHSIPEPVGIVIHTPQGK
                     IICTGDFKFDFTPVGDPADLQRMAALGEEGVLCLLSDSTNAEIPTFTNSEKVVGQSIL
                     KIIEGIHGRIIFASFASNIYRLQQAAEAAVKTGRKIAVFGRSMEKAIVNGIELGYIKV
                     PKGTFIEPSELKNLHASEVLIMCTGSQGESMAALARIANGTHRQVTLQPGDTVIFSSS
                     PIPGNTTSVNKLINTIQEAGVDVIHGKVNNIHTSGHGGQQEQKLMLSLIKPKYFMPVH
                     GEYRMQKVHAGLAMDIGIPKENIFIMENGDVLALTSDSARIAGHFNAQDIYVDGNGIG
                     DIGAAVLRDRRDLSEDGVVLAVATVDFNTQMILAGPDILSRGFIYMRESGDLIRESQR
                     VLFNAIRIALKNKDASIQSVNGAIVNALRPFLYEKTEREPIIIPMVLTPDKH"
     gene            complement(17377..17607)
                     /locus_tag="VHC05_000096"
     CDS             complement(17377..17607)
                     /locus_tag="VHC05_000096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-dependent RNA polymerase auxiliary subunit
                     epsilon family protein"
                     /protein_id="HEQ5401446.1"
                     /translation="MIYKVFYQETKDQSPRRESTKALYLNIDATDELDGRIKARRLVE
                     DNTYYNVEFIELLSDKHLDYEKETGVFELTEF"
     gene            17891..18589
                     /gene="tsaB"
                     /locus_tag="VHC05_000097"
     CDS             17891..18589
                     /gene="tsaB"
                     /locus_tag="VHC05_000097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HEQ5401447.1"
                     /translation="MKTLAFDTSNKTLSLAILDDETLLADMTLNIQKNHSVSLMPAID
                     FLMTCTDLKPQDLERIVVAKGPGSYTGLRVAVATAKTLAYSLNIALVGISSLYALAAS
                     TCKQYPNTLVVPLIDARRQNAYVGYYRQGKSVMPQAHASLEVIIEQLVKEGQLIFVGE
                     TTPFAEQIQKKLPQAILLPTLPSAYECGLLGQSLAPENVDAFVPQYLKRVEAEENWLK
                     DNEIKDDSHYVKRI"
     gene            18561..19016
                     /gene="rimI"
                     /locus_tag="VHC05_000098"
     CDS             18561..19016
                     /gene="rimI"
                     /locus_tag="VHC05_000098"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HEQ5401448.1"
                     /translation="MIVTTLSESNMKTVEEQAKNIYQLLEMVYGTSPWTLEQVLIDIR
                     RDQTDYFLLYDHDKLLGFLAVQDLAGEVEMTQIAILPSHQGLGLASQLMTHLDSIESD
                     IFLEVRESNHRAQGLYQKFGFKLIGKRPDYYRNPIETALLMKREGKHDR"
     gene            19006..20034
                     /gene="tsaD"
                     /locus_tag="VHC05_000099"
     CDS             19006..20034
                     /gene="tsaD"
                     /locus_tag="VHC05_000099"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HEQ5401449.1"
                     /translation="MTDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGG
                     VVPEVASRHHVEVITTCFEDALQEAGISASDLSAVAVTYGPGLVGALLVGLAAAKAFA
                     WANHLPLIPVNHMAGHLMAAREQKPLVYPLIALLVSGGHTELVYVPEPGDYHIIGETR
                     DDAVGEAYDKVGRVMGLTYPAGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSA
                     FINLHHNAKQKGNELILEDLCASFQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQ
                     GLRDRLAQEITHIEVVIPKLRLCGDNAGMIALAAAIEYDKQHFANMSLNAKPSLAFDQ
                     FPDSFVIN"
     gene            complement(20205..20474)
                     /gene="rpsN"
                     /locus_tag="VHC05_000100"
     CDS             complement(20205..20474)
                     /gene="rpsN"
                     /locus_tag="VHC05_000100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S14"
                     /protein_id="HEQ5401450.1"
                     /translation="MAKKSKIAKYQKQLQLIEQYADLRRDLKAKGDYESLRKLPRDSN
                     PNRLKNRDKIDGRPHAYMRKFGVSRINFRDLAHKGQLPGVTKASW"
     gene            complement(20694..21452)
                     /locus_tag="VHC05_000101"
     CDS             complement(20694..21452)
                     /locus_tag="VHC05_000101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEQ5401451.1"
                     /translation="MSTNDLTKKLKKLKHVQVYNTIFQLIQDGTYSPGMQLPSEPELA
                     RQLNVSRMTLRKSLALLQEDHLIKNIRGKGNFILKTPETKYHQGFEYLQHPIYASLSS
                     EITKVELEYRIEVPTVAITASLKQETPVVIIVDRWYHSQNKAIAYSLSFIPIEVISKY
                     AINLNQEEPLLTFLEEKIYESGKASHSCNQIGYTKTGNYTATKYTLSENSAFILIQET
                     LYNGKDILVSTKHYVPADLFDLKVQSQSCQSDTH"
     gene            21693..22472
                     /gene="udp"
                     /locus_tag="VHC05_000102"
     CDS             21693..22472
                     /gene="udp"
                     /locus_tag="VHC05_000102"
                     /EC_number="2.4.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uridine phosphorylase"
                     /protein_id="HEQ5401452.1"
                     /translation="MQNYSGEVGLQYHLQIRPGDVGRYVIMPGDPKRCAKIAEHFDNA
                     VLVADSREYVTYTGTLNGEKVSVTSTGIGGPSASIAMEELKLCGADTFIRVGTCGGID
                     LDVKGGDIVIATGAIRMEGTSKEYAPIEFPAVADLEVTNALVNAAKKLGYTSHAGVVQ
                     CKDAFYGQHEPERMPVSYELLNKWEAWKRLGTKASEMESAALFVAASHLGVRCGSDFL
                     VVGNQERNALGMDNPMAHDTEAAIQVAVEALRTLIENDKSQ"
     gene            22493..23695
                     /locus_tag="VHC05_000103"
     CDS             22493..23695
                     /locus_tag="VHC05_000103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NupC/NupG family nucleoside CNT transporter"
                     /protein_id="HEQ5401453.1"
                     /translation="MQFIYSIIGILLVLGIVYAISFNRKSVSLSLIGKALIVQFIIAL
                     ILVRIPLGQQIVSVVSTGVTSVINCGQAGLNFVFGSLADSGAKTGFIFAIQTLGNIVF
                     LSALVSLLYYVGILGFVVKWIGKGVGKIMKSSEVESFVAVANMFLGQTDSPILVSKYL
                     GRMTDSEIMVVLVSGMGSMSVSILGGYIALGIPMEYLLIASTMVPIGSILIAKILLPQ
                     TEPVQKIDDIKMDNKGNNANVIDAIAEGASTGAQMAFSIGASLIAFVGLVSLINMMLS
                     GLGIRLEQIFSYVFAPFGFLMGFDHKNILLEGNLLGSKLILNEFVSFQQLGHLIKSLD
                     YRTALVATISLCGFANLSSLGICVSGIAVLCPEKRSTLARLVFRAMIGGIAVSMLSAF
                     IVGIVTLF"
     gene            23725..24396
                     /gene="deoC"
                     /locus_tag="VHC05_000104"
     CDS             23725..24396
                     /gene="deoC"
                     /locus_tag="VHC05_000104"
                     /EC_number="4.1.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="HEQ5401454.1"
                     /translation="MEVKDILKTVDHTLLATTATWPEIQTILDDAMAYETASACIPAS
                     YVKKAAEYVSGKLAICTVIGFPNGYSTTAAKVFECEDAIKNGADEIDMVINLTDVKNG
                     DFDTVEEEIRQIKAACQDHILKVIVETCQLTKEELIELCGVVTRSGADFIKTSTGFST
                     AGATFEDVEVMAKYVGEGVKIKAAGGISSLEDAETFIALGASRLGTSRIIKIVKNEAT
                     KTDSY"
     gene            complement(24491..25660)
                     /locus_tag="VHC05_000105"
     CDS             complement(24491..25660)
                     /locus_tag="VHC05_000105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HEQ5401455.1"
                     /translation="MTQYDTIIIGGGPAGMMAAISSSYYGYKTLLIEKNRRLGKKLAG
                     TGGGRCNVTNSGNLDDLMAGIPGNGRFLYSVFSQFDNHDIIAFFEENGVKLKEEDHGR
                     MFPTTDKSRTIIDALEKKIKALGGKVLTNTEVVSVKKQDDLFYLKSADQTFSCHKLIV
                     TTGGKAYPSTGSTGFGHDIARHFKLTVTDLEAAESPLLTDFPHKVLQGISLDDVTLSY
                     DKHVITHDLLFTHFGLSGPAALRLSSFVKGGEIAELDFLPHLSTDDLTAYLSDQRDKN
                     IKNALKGLLPERVADFLSENYPEKVKQLSPKQEKELLDKLKHLQIPITGKMSLAKSFV
                     TKGGVDLKEINPKTLESKKVPGLYFAGEVLDINAHTGGFNITSALCSGWIAGKSS"
     gene            25865..26395
                     /locus_tag="VHC05_000106"
     CDS             25865..26395
                     /locus_tag="VHC05_000106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="HEQ5401456.1"
                     /translation="MGIEKTVSELADILGVSRQTVNNRVKSLPEEDLDKNEKGVTVVK
                     RSGLVKLEEIYKKTIFDDEPISEETKQRELLEILVDEKNTEITRLYEQLKAKDAQLAS
                     KDEQMRVKDVQIAEKDKQLDQQQQLTAKAMADKETLKLELEEAKAEANQARLQVEEVQ
                     AEVGPKKGFFTRLFAK"
     gene            26444..27031
                     /locus_tag="VHC05_000107"
     CDS             26444..27031
                     /locus_tag="VHC05_000107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HEQ5401457.1"
                     /translation="MQHLDTYIAFDLEFNTVNDVSHVIQVSAVKYDHHKEVDSFDTYV
                     YTDVPLQSFINGLTGITSDKIAAAPKVEEVMAAFKNFVGELPLIGYNAQKSDLPILAE
                     NGLDLRDQYQIDLFDEAYDRRSADLNGIANLRLQTVATFLGIKGRGHNSLEDARMTAA
                     IYKSFLETDTNKAYLSQQEEVTTDNPFAALGDFFD"
     gene            27184..27477
                     /locus_tag="VHC05_000108"
     CDS             27184..27477
                     /locus_tag="VHC05_000108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HEQ5401458.1"
                     /translation="MSQFYSTGELANLAGVSIRTVQYYDQRGILIPTALTAGGRRLYT
                     DSDLEQLRMICFLRDLGFSIAGHTPRTRKLTCSHCHQKSYCLELAKEDTVSRG"
     gene            complement(27534..27833)
                     /locus_tag="VHC05_000109"
     CDS             complement(27534..27833)
                     /locus_tag="VHC05_000109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016503193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="HEQ5401459.1"
                     /translation="MMNMQNMMKQAQKLQKQMEQKQADLAAMQFTGKSAQDLVTATFT
                     GDKKLVGIDFKEAVVDPEDVETLQDMTTQAINDALTQIDETTKKTLGAFAGKLPF"
     gene            complement(28026..28400)
                     /locus_tag="VHC05_000110"
     CDS             complement(28026..28400)
                     /locus_tag="VHC05_000110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988207.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5401460.1"
                     /translation="MSAKKTFFASNLKYLRLKKNMEQLELANLLGRKSSSSISEWEKG
                     KYTPKSGLLSDIAAIFDVSLTALMEEDLTLESKGVSYQLPQRELAMISEQLSENNYTK
                     WVDFAQILLEQQAKEDRELDNH"
     gene            28570..28791
                     /locus_tag="VHC05_000111"
     CDS             28570..28791
                     /locus_tag="VHC05_000111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5401461.1"
                     /translation="MTKSTLKELRTTKKMTQQELSHLTGISVRTIARYEKDTKKLRRA
                     KYEKLKGIAQALAVSVDDIFLGIDSEFMN"
     gene            complement(28871..31153)
                     /locus_tag="VHC05_000112"
     CDS             complement(28871..31153)
                     /locus_tag="VHC05_000112"
                     /EC_number="3.4.14.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Xaa-Pro dipeptidyl-peptidase"
                     /protein_id="HEQ5401462.1"
                     /translation="MRYNQFSYIPTSLERAAEELKELGFDLDLQKTAKANLESFLRKL
                     FFHYPDSDYPLSHLIAKNDMDALSFFQSEQELSKEVFDLLALQVLGFIPGVDFTEADA
                     FLDKLAFPIHFDETEIIKHIHHLLATRCKSGMTLIDDLVSQGMLTMDNDYHFFNGKSL
                     ATFDTSQLIREVVYVEAPLDTDQDGQLDLIKVNIIRPQSQKPLPTLMTPSPYHQGINE
                     VANDKKLYRMEKELVVKKRRQITVEDRDFIPLETQPCKLPIGQNLESFSYINSYSLND
                     YFLARGFANIYVSGVGTAGSTGFMTSGDYAQIESFKAVIDWLNGRATAYTSHSKTHQV
                     RADWANGLVCTTGKSYLGTMSTGLATTGVDGLAMIIAESAISSWYNYYRENGLVCSPG
                     GYPGEDLDVLTELTYSRNLLAGDYLRHNDRYQELLNQQSQALDRQSGDYNQFWHDRNY
                     LKNAHQIKCDVVYTHGLQDWNVKPRQVYEIFNALPSTINKHLFLHQGEHVYMHNRQSI
                     DFRESMNALLCQKLLGLANDFSLPEMIWQDNTCPQNWQERKVFGTSTIKELDLGQELL
                     LIDNHYGEDEFKAYGKDFRAFKAALFEGKANQALVDILLEEDLPINGEIVLQLKVKSS
                     ENKGLLSAQILDYGKKKRLGDLPIALTQSSIDNGQNFSRESLKELPFREDSYRVISKG
                     FMNLQNRNNLSSIETIPNNKWMTVRLPLQPTIYHLEKGDTLRVILYTTDFEHTVRDNS
                     NYALTIDLSQSQLIVPIASN"
     gene            complement(31175..31834)
                     /locus_tag="VHC05_000113"
     CDS             complement(31175..31834)
                     /locus_tag="VHC05_000113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HEQ5401463.1"
                     /translation="MNHHILQRYIDNHNFPIIEKSYHKYLTFESLEEDFTYILKDGIV
                     KQSVLSKYGMEFNLRYVTGLEITSVLNTGYSKDMGEPYNVRIESEKASFYKVRRSAFL
                     KDINEDIELQGYVKDFYHNRLQKSMKKMQCMLTNGRIGAISTQIYDLMTLFGEELPNG
                     QILINFVITNEELGKFCGISTASSVSRILKQLKEKNIIRIDKQHIIITNLDKLKDNIV
                     F"
     gene            32000..33196
                     /locus_tag="VHC05_000114"
     CDS             32000..33196
                     /locus_tag="VHC05_000114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEQ5401464.1"
                     /translation="MEEKLFNKHFVAITVINFIVYMVYYLFTVIIAFVATRELGAQTS
                     QAGLATGIYILGTLLARLIFGKQLEVFGRRLVLRGGAIFYLLTTLAYFYMPTISMMYL
                     VRFLNGFGYGVVSTATNTIVTAYIPACKRGEGINFYGLSTSLAAAIGPFVGTFMLDNL
                     HIDFRMIIVLCSVLIGCVVVGAFAFPVKNMSLNAEQLAKTKSWTVDSFIEKKALFITA
                     IAFLMGIAYASVLGFQKLYTSEIHLTAVGAYFFVVYALIITITRPAMGRLMDAKGDKW
                     VLYPSYLFLAMGLFLLGSVSSGGSYLLSGALIGFGYGTFMSCGQAASIQGVDEHRFNT
                     AMSTYMIGLDLGLGAGPYLLGLIKDLALGSGVASFRHLFWLAAVIPLICTLLYLLKTK
                     TRQVVS"
     gene            33668..34516
                     /locus_tag="VHC05_000115"
     CDS             33668..34516
                     /locus_tag="VHC05_000115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin family protein"
                     /protein_id="HEQ5401465.1"
                     /translation="MEMTWTVKYITEFIATAFLIILGNGAVANVDLKGTKGHNSGWLV
                     IAFGYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHVLQYVVAQLLGAIFGQ
                     LVVVMVYKPYFMKTENPNHVLGSFSTISSLDNGQKDSHKVSYINGFLNEFVGSFVLFF
                     GALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGIGFLVMVLVTSL
                     GGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPILAAIVAVAAF
                     KYLYIR"
     gene            complement(34852..35748)
                     /locus_tag="VHC05_000116"
     CDS             complement(34852..35748)
                     /locus_tag="VHC05_000116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HEQ5401466.1"
                     /translation="MNEMLILRLIQALLVSAMLFIFFMLVKHLKKNKINPFKRFWTGF
                     WIGLLTDALDTLGIGSFATTTTCFKLTKLVTDDRQLPGTMTVAHVLPVLIQSLCFIFV
                     VKVEVLTLLAMAAAAFIGAYLGTHITKNWHAPTVQRILGSLLIIAAIIMIIRIIYHPG
                     EHLSDTIHGLHGIWLFVGIGFNFIVGVLMTMGLGNYAPELIFFSLMGLSPTVAMPVMM
                     LDAAMIMTASSSQFIKANRVSWDGFAGIVSGGIIGVLLAVFFLTNLDINSLKLLVIAI
                     VFFTGGMLIRSSFTSHKQQTNR"
     gene            36046..36798
                     /locus_tag="VHC05_000117"
     CDS             36046..36798
                     /locus_tag="VHC05_000117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CppA family protein"
                     /protein_id="HEQ5401467.1"
                     /translation="MTLMENITFKTPVLRVNDRDLNIAFYQNNLGLRLVSEENAIAIF
                     SSWGEGQECFVIEESPSVRTRAVEGPKKVNTIVIKTNQPKEIEQLLAHGAYYDTLFKG
                     QNGYAFETISPEGDRFLLHAEQDIKHLQGTDLPSLEKDATFKGLTQFKFDIIVLNVIS
                     EERSKAFYRDLFSDQLPITMDFIQEEGPDLAIDPHIAWDLEILEFQVSKDYDMKVLKA
                     TLEEDGHKVYIDKKHKVLVLSDPSQIEVWFTK"
     gene            36783..37733
                     /locus_tag="VHC05_000118"
     CDS             36783..37733
                     /locus_tag="VHC05_000118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-lactamase family protein"
                     /protein_id="HEQ5401468.1"
                     /translation="MVYEMTLAVIKCIENHLHKKVYKGASLALFQSGRWQEYHIGTID
                     GRRPVDANLVYDLASVSKVVGVATICNILLNNGTLALDDPLKAYYPSIADATVTIRQL
                     LTHTSGLDPYIPNRDVLNAQQLRKALNHLTQKENKNFYYTDVNFLLLGFMLEELFSES
                     LDQIFDKTIFTPFGMYHTSFGPRPEAVPTLKGVSDGEVHDPKAKILKKHSGSAGLFST
                     LADLESFSNHYLNDPFSDCLWRNYSQQTIERSLGWNLDGDWISHTGYTGPFLMLNKKE
                     QTAAIFLTNRTYDEDDKSKWLKERQLLYNALKHDLTTPVS"
     gene            complement(37913..40240)
                     /gene="pflB"
                     /locus_tag="VHC05_000119"
     CDS             complement(37913..40240)
                     /gene="pflB"
                     /locus_tag="VHC05_000119"
                     /EC_number="2.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase"
                     /protein_id="HEQ5401469.1"
                     /translation="MATVKTNTDVFEKAWEGFKGTDWKEKASVSRFVQANYTPYDGDE
                     SFLAGATERSLHIKKVIEETKAHYEATRFPYDTRPTSIADIPAGFIDKENELIYGIQN
                     DELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFRAYTSNIRRA
                     RHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNAITEIDEESIRLREEV
                     NLQYQALGEVVKLGDLYGVDVRRPAQNVKEAIQWVNIAFMAVCRVINGAATSLGRVPI
                     VLDIFAERDLARGTFTESEIQEFVDDFVLKLRTVKFGRTKAYDALYSGDPTFITTSMA
                     GMGNDGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWTDQLPETFRRYCMKMSHKHSSI
                     QYEGVTTMAKEGYGEMSCISCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNGGY
                     DDVHRDYKVFNVVEPITSEVLEYDEVMANFEKSLDWLTDTYVDALNIIHYMTDKYNYE
                     AVQMAFLPTHQRANMGFGICGFANTVDTLSAIKYATVKTIRDENGYIYDYEVTGDFPR
                     YGEDDDRVDDIAKWLMEAYHTRLASHKLYKNAEASVSLLTITSNVAYSKQTGNSPVHR
                     GVFLNEDGTVNTSQVEFFSPGANPSNKAKGGWLQNLNSLAKLEFSHANDGISLTTQVS
                     PRALGKTFDEQVDNLVTVLDGYFENGGQHVNLNVMDLNDVYDKIMNGEDVIVRISGYC
                     VNTKYLTPEQKTELTQRVFHEVLSMDDAAEAISSK"
     gene            40449..41543
                     /gene="dinB"
                     /locus_tag="VHC05_000120"
     CDS             40449..41543
                     /gene="dinB"
                     /locus_tag="VHC05_000120"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase IV"
                     /protein_id="HEQ5401470.1"
                     /translation="MLIFPLINDTSRKIIHIDMDAFFAAVEERDNPALKGKPVVIGKD
                     PRETGGRGVVSTCNYEARKYGIHSAMSSKEAYERCPKAIFISGNYEKYRTVGDQIRRI
                     FKRYTDVVEPMSIDEAYLDVTNNKLGIKSAVKIAKLIQHDIWKEVGLTCSAGVSYNKF
                     LAKLASDFEKPHGLTLVLKEDALCFLAKLPIEKFHGVGKKSVEKLHDMGIYTGQDLLA
                     VPEMTLIDHFGRFGFDLYRKARGISNSPVKSDRIRKSIGSERTYAKLLYQETDIKAEI
                     SKNAKRVAALLQDHKKLGKTIVLKVRYADFTTLTKRVTLPELTRNAAQIEQVAGDIFD
                     SLSENPAGIRLLGVTMTNLEDKVADISLDL"
     gene            complement(41636..42118)
                     /locus_tag="VHC05_000121"
     CDS             complement(41636..42118)
                     /locus_tag="VHC05_000121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401471.1"
                     /translation="MISYEKVRQALKTSTIAIIILNGLGVVLSLMGFAGIFYLQSQLK
                     NEAFRAQLTTEQLAQLQSSMTPFMIFLSVLNVLAIIAIIIFCTQNLSKLKQGLTVSYI
                     PYILGLILSVIGLVNQFTTTLSMVGTILILIQAALYGFAFYKAKNLNEKGDDTDQAML
                     "
     gene            complement(42209..44662)
                     /locus_tag="VHC05_000122"
     CDS             complement(42209..44662)
                     /locus_tag="VHC05_000122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent RecD-like DNA helicase"
                     /protein_id="HEQ5401472.1"
                     /translation="MEHFFTGTVDRIIFENAANFFKILLLAIEDTDSDIDDFEIIITG
                     TMADIIEGDDYTFWGELTQHPKYGQQLKLSRYQKIKPSSSGLVNYFSSDHFKGIGKKT
                     AEKIIALYGHNTIDHILEDPSKLETISGLSKANRQAFVAKLKLNYGTEQLIAGLVELG
                     LSNRFALQAFEKYKEEALDLVKENPYQLVEDLQGFGFKMADALAENLGIESDSPKRFR
                     AALLHCLLEESINRGDTYVQARQLLDFAITLLEDARQVECDPAAVAEQLSELIIEGKI
                     KNSDTKLFDASLYFAEEGIANNISRLLDTPLSQSFSHDTIQTTIQAVQKDFAITYDQV
                     QQEAITKALTSKVFLLTGGPGTGKTTVIRGILQAYANLHQIDLDKKDLPILLAAPTGR
                     AARRMNELTGLPSATIHRHLGLNGDNDYQAMEDYLDCDLLIVDEFSMVDTWLANQLLG
                     AINSTTQVIIVGDSDQLPSVGPGQVLSDLLKVNSLPQIALQKIFRQSQESTIVNLADQ
                     MRRGILAADFRDKKADRSYFEAQAAFIPDMIQKIVLSAIKSGIPAEEIQILAPMYKGQ
                     AGINHLNQLMQELLNPLQGQTEFLFNDTHFRKGDKVLHLVNDAQLNVFNGDIGYITDL
                     IPAKYTESKQDELILDFDGSEVTYPRNEWLKLTLAYAMSIHKSQGSEFQVVILPITRQ
                     SGRLLQRNVIYTAITRSKSKLILLGEYTAFEYAIKHEGDKRQTYLIERFQEQSDLASS
                     QPNQELKSKEQTSLFSNTATLEDDSQKSSSQSTNSNPTENSQSDNDDFRLTPENYSTI
                     DSMIGLTESDIALFFQKKS"
     gene            complement(44720..45313)
                     /gene="lepB"
                     /locus_tag="VHC05_000123"
     CDS             complement(44720..45313)
                     /gene="lepB"
                     /locus_tag="VHC05_000123"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HEQ5401473.1"
                     /translation="MKQFIKEWGPFTLFLILFGLSRLFLWQAVKVDGHSMDPTLAHGE
                     RLIVFNQARIDRFDIVVAQEEENGQKKEIVKRVVGLPGDTISYNDDTLYINGKKTVEP
                     YLAEYLKQFKNDKLQKTYAYNTLFQQLAETSDAFTTNSEGQTRFEMSVPKGEYLLLGD
                     DRIVSRDSREVGSFKKENLIGEVKARFWPLNKMTVFN"
     gene            complement(45324..46226)
                     /locus_tag="VHC05_000124"
     CDS             complement(45324..46226)
                     /locus_tag="VHC05_000124"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HIII"
                     /protein_id="HEQ5401474.1"
                     /translation="MNTLVLKIDAILSKHLKKQLAPYTINSQNTYVAFAAKKNGVTVL
                     LYKSGKLVLQGNGANALAQELNLPVAKTVFEASNNSQDIPIIGSDEVGNGSYFGGIAV
                     VASFVDPKDHSFLKKLGVDDSKKLSDKTIQQIAPLLEKQIPHQSLLLSPKKYNELVGK
                     SKPYNAISIKVALHNQAIFLLLQKGIQPKQIVIDAFTSQSNYEKHLKKEKSHFPNPLT
                     FQEKAESHYLAVAVSSIIARNLFLDNLDQLGQDLGYQLPSGAGSASDKVASQLLAAYG
                     MSSLEYSAKLHFANTHKAQALLTK"
     gene            46383..46691
                     /locus_tag="VHC05_000125"
     CDS             46383..46691
                     /locus_tag="VHC05_000125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003045196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401475.1"
                     /translation="MKSINRYKFTFGEKTLTLTTDKDNLFMEEVERVAKEKYQALKNH
                     LPEADDETIAILMAINTLSTQLSREIAIEKMEAEILDLRQKTLVGLQEKANQIDVNEV
                     "
     gene            46694..47239
                     /locus_tag="VHC05_000126"
     CDS             46694..47239
                     /locus_tag="VHC05_000126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CvpA family protein"
                     /protein_id="HEQ5401476.1"
                     /translation="MLSLLIVLVLTWNFYIGYSRGIILQSFYVLGALLSLLVANRFYI
                     GLAHKLTLWIPYSNPVEGTSVFFFKSVDIFVLDKVYYAGLAFFIIFLLGYALSRFLGI
                     FVHFLLLDYFDNQWTKCLSGGLALLVSLLFLNMLLSIFATVPMPFLQHYLHSSFLARL
                     VIEHLPPLTIIIQKLWIQAII"
     gene            47388..49727
                     /locus_tag="VHC05_000127"
     CDS             47388..49727
                     /locus_tag="VHC05_000127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017650215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HEQ5401477.1"
                     /translation="MNNKILEQLEFNKVKELLLPYLKTEQSQEELLELEPMTEAPKIE
                     KSFNEISDMEQIFVEHHSFGIVSLSSISESLKRLELSADLNIQELLAIKKVLQSSSDM
                     IHFYSDLDNVSFQSLDRLFENLEQFPNLQGSFQAINDGGFLEHFASPKLERIRRQLTN
                     SERRVRQILQDMLKEKAELLSENLIASRSGRSVLPVKNTYRNRISGVVHDISSSGSTV
                     YIEPRAVVTLNEEITQLRADERHEEGRILHTFSDLLRPHVATIRNNAWILGHLDFVRA
                     KYLFMSDNKATIPKISDDSTLALINVRHPLLSNPVANDLHFDHDLTAIVITGPNTGGK
                     TIMLKTLGLAQLMGQSGLPVLADKGSKIAVFNNIFADIGDEQSIEQSLSTFSSHMTHI
                     VSILNEADRNSLVLFDELGAGTDPQEGASLAMAILEHLRLSHIKTMATTHYPELKAYG
                     IETNFVENASMEFDAETLSPTYRFMQGVPGRSNAFEIASRLGLAPFIVKQAKQMTDSD
                     SDVNRIIEQLEAQTLETRRRLDHIKEVEQENLKFNRAVKKLYNEFSHERDKELEKIYQ
                     EAQEIVDMALNESDTILKKLNDKSQLKPHEIIDAKAQIKKLAPQVDLSKNKVLNKAKK
                     IKAARAPRIGDDIIVTSYGQRGTLTSQLKDGRWEAQVGIIKMTLTQDEFSLVRVQEEQ
                     KVKNKQINVVKKADSSGPRARLDLRGKRYEAAMQELDHFIDQALLNNMGQVDIIHGIG
                     TGVIREGVTKYLRRNKHVKHFAYAPQNAGGSGATIVTLG"
     gene            49731..50231
                     /locus_tag="VHC05_000128"
     CDS             49731..50231
                     /locus_tag="VHC05_000128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017767232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HEQ5401478.1"
                     /translation="MESYEHFYAKLSQPFRKTPQLIILLNVLLKIITGVMYILYPSFL
                     IFTLWQGMTFQLWLRLLIIPAVGFIALSYIRKRFDFPRPYEKWNIKPLIDKDTKGRSM
                     PSRHVFSATMISMCLLRYYVYFGIVCLILSVLLAICRVIAGIHYPKDVIVGYLIGLML
                     GLCLLI"
     gene            50312..50626
                     /gene="trxA"
                     /locus_tag="VHC05_000129"
     CDS             50312..50626
                     /gene="trxA"
                     /locus_tag="VHC05_000129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001162959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HEQ5401479.1"
                     /translation="MALEVTDATFVEETKEGLVLIDFWATWCGPCRMQAPILEQLSQE
                     IDEDELKILKMDVDENPETARQFGIMSIPTLMLKKDGEVVKQVAGVHTKDQLKAIIAE
                     LS"
     gene            complement(50678..51265)
                     /locus_tag="VHC05_000130"
     CDS             complement(50678..51265)
                     /locus_tag="VHC05_000130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5401480.1"
                     /translation="MEIGQQMIRYRKQQTLSQEELVEKVYVSRQSISNWENDKTYPDI
                     HSLLLLSQIFQVSLDQLIKGDIEKMKYTITQVDKKNFERDTKVMVTLMILLMISSYPL
                     VYFLEWLGLGIFVLLSIITMTYANRVERFKKKYDVQPYKEILAVSNGKLLDEIEKREE
                     RAKLPYQKPLIVTVFFLITVVIVFASRFMFTWLFH"
     gene            complement(51442..52566)
                     /gene="mutY"
                     /locus_tag="VHC05_000131"
     CDS             complement(51442..52566)
                     /gene="mutY"
                     /locus_tag="VHC05_000131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015632237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="A/G-specific adenine glycosylase"
                     /protein_id="HEQ5401481.1"
                     /translation="MWDNETIASFRRTLLGWYDQEKRDLPWRRTTNPYYIWVSEIMLQ
                     QTQVNTVIPYYKRFLEWFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMVD
                     FGGIFPHTYDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGD
                     PKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGT
                     YGKYPIKNPKKKPKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQ
                     LDLFDDNQSNPIIWQTQNETFEREYQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVK
                     ATDLPNAPHLKWVAIEDFSLYPFATPQKKMLETYLKQKNA"
     gene            52764..53057
                     /locus_tag="VHC05_000132"
     CDS             52764..53057
                     /locus_tag="VHC05_000132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401482.1"
                     /translation="MFQKLKNLIDRYSWFVFIMMILVLFLNYIYPFDPSLSGLQLEWL
                     IMTQVFPGLGIVCAMVAIIFKKFNLFVLALILYFALWLKLFLAFSFFTYFLGV"
     gene            53230..53520
                     /locus_tag="VHC05_000133"
     CDS             53230..53520
                     /locus_tag="VHC05_000133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018030687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="HEQ5401483.1"
                     /translation="MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKDWE
                     KRRLAYEINDFREGLYHIVNLEATDAAALNEFDRLSKINGDILRHMIVKLDA"
     gene            53542..54033
                     /locus_tag="VHC05_000134"
     CDS             53542..54033
                     /locus_tag="VHC05_000134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HEQ5401484.1"
                     /translation="MINNVVLVGRMTKDAELRYTPSQVAVATFTLAVNRTFKSQNGER
                     EADFINCVIWRQPAENLANWAKKGALIGVTGRIQTRNYENQQGQRVYVTEVVADNFQM
                     LESRATREGGSTGSFNGGFNNNTSSSNSYSAPAQQTPNFGRDDSPFGNSNPMDISDDD
                     LPF"
     gene            54197..54436
                     /locus_tag="VHC05_000135"
     CDS             54197..54436
                     /locus_tag="VHC05_000135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="HEQ5401485.1"
                     /translation="MAQQRRGGFKRRKKVDFIAANKIEYVDYKDTELLSRFVSERGKI
                     LPRRVTGTSAKNQRKVTTAIKRARVMALMPYVNED"
     gene            complement(54567..55223)
                     /locus_tag="VHC05_000136"
     CDS             complement(54567..55223)
                     /locus_tag="VHC05_000136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1129 domain-containing protein"
                     /protein_id="HEQ5401486.1"
                     /translation="MELQELTKKNQEFIHTATNKLIQDGKSDEDIKLILEEAIPAILE
                     NQKKGVTARNLLGTPTAWAASFSQDPSQRAAETDKNTNPWLMWLDTSLLFIGIVALLN
                     GIMTFFNTNATVTGLISLLALGFGGGASMYATYYFIYRHLGKDKSLRPSWFKIIAALS
                     LAMLIWIALYSATAFLPTSLNPQLPPLVLLIIGGVSLALRYYLQRKYNIQNTMSPVNK
                     "
     gene            complement(55355..56299)
                     /locus_tag="VHC05_000137"
     CDS             complement(55355..56299)
                     /locus_tag="VHC05_000137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003085337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HEQ5401487.1"
                     /translation="MKQMFLSSAIEFKEIETFEPGAWIKLVNPSQEESMKIADQFNID
                     ISDLRAPLDVEETSRIAVEDDYTLIIVDVPIYEERNNKSYYITMPLGIIVTENAVITT
                     CLHDMTLFDHFHNRRVKNFYTFMKTRFVFQILYRNAELFLTALRTIDRQSERLEAQLE
                     AATRNEELIDMMELEKSIVYLKASLKFNERIVKKLSSSTSSLKKYIEDEDLLEDTLIE
                     TQQAIEMAGIYENVLNAMTETTASIINNNQNTIMKTLALMTMALDIPTVIFSAYGMNF
                     QNNWLPLNGLEHAFWYITLIAMLLSSFVVIYFIRKKWF"
     gene            56502..59330
                     /gene="uvrA"
                     /locus_tag="VHC05_000138"
     CDS             56502..59330
                     /gene="uvrA"
                     /locus_tag="VHC05_000138"
                     /EC_number="3.1.25.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HEQ5401488.1"
                     /translation="MQNKIIIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFD
                     TIYAEGQRRYVESLSAYARQFLGNMEKPDVDSIDGLSPAISIDQKTTSKNPRSTVGTV
                     TEINDYLRLLYARVGTPYCINGHGAITASSAEQIVEQVLALPERTRMQILAPIVRRKK
                     GQHKTIFEKIQKDGYVRVRVDGDIFDVTEVPELSKSKMHNIEVVIDRLVNKDGIRSRL
                     FDSVEAALRLGDGYLMIDTMDGNELLFSEHYSCPVCGFTVPELEPRLFSFNAPFGSCP
                     TCDGLGIKLEVDLDLVVPDPSKSLKEGALAPWNPISSNYYPTMLEQAMASFGVDMDTP
                     FEALTEEERDLVLYGSGDREFHFHYVNDFGGERNIDIPFEGVVTNVNRRYHETNSDYT
                     RNVMRGYMNELTCATCHGYRLNDQALCVHVGGEEGPHIGQISELSIADHLQLLEELEL
                     TENESTIAKPIVKEIHDRLTFLNNVGLNYLTLSRAAGTLSGGESQRIRLATQIGSNLS
                     GVLYILDEPSIGLHQRDNDRLIESLKKMRDLGNTLIVVEHDEDTMMQADWLIDVGPGA
                     GEFGGEIIASGTPKQVAKNKKSITGQYLSGKKFIPVPLERRSGNGRFIEIKGAAQNNL
                     QSLDVRFPLGKFIAVTGVSGSGKSTLVNSILKKAVAQKLNRNADKPGKYHSISGIEHI
                     ERLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNEAKIHGYKKGRFSFNVKGGRC
                     EACSGDGIIKIEMHFLPDVYVPCEVCHGRRYNSETLEVHYKEKNIAEVLDMTVDDALV
                     FFSAIPKIARKIQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSLYIL
                     DEPTTGLHTDDIARLLKVLERFVDDGNTVLVIEHNLDVIKSADHIIDLGPEGGVGGGQ
                     IVATGTPEEVAQVKESYTGHYLKVKLQQ"
     gene            59446..60519
                     /locus_tag="VHC05_000139"
     CDS             59446..60519
                     /locus_tag="VHC05_000139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HEQ5401489.1"
                     /translation="MSGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAAT
                     VLITAKRHVLITDSRYTLLAKASVEGFDIIESRTPLKVVAELLEADQIDCLGFEDQVS
                     FSFYQAMQAELSGITLLAQSGFVEHLRLIKDTSEIDTIAKACSISDKAFEDALDFIKP
                     GTTTERDLANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDF
                     GCYYNHYVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKASAGMTYSDFDGIPRQL
                     IAEAGYGSRFTHGIGHGIGLDIHENPFFGKSEQLLQAGMVVTDEPGIYLDNKYGVRIE
                     DDLVITKTGCQVLTLAPKELIVL"
     gene            60554..61015
                     /locus_tag="VHC05_000140"
     CDS             60554..61015
                     /locus_tag="VHC05_000140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComE"
                     /protein_id="HEQ5401490.1"
                     /translation="MTNRLSWQDYFMANAELISKRSTCDRAFVGAVLVKDNRIIATGY
                     NGGVSATDNCNEAGHYMEDGHCIRTVHAEMNALIQCAKEGISTDGTEIYVTHFPCINC
                     TKALLQAGITKITYKAHYRPHPFAIELMEKKGVAYVQHDVPQIVLGGDKEQ"
     gene            61111..61668
                     /gene="efp"
                     /locus_tag="VHC05_000141"
     CDS             61111..61668
                     /gene="efp"
                     /locus_tag="VHC05_000141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor P"
                     /protein_id="HEQ5401491.1"
                     /translation="MIEASKLKAGMTFEAEGKLIRVLEASHHKPGKGNTIMRMKLRDV
                     RTGSTFDTTYRPDEKFEQAIIETVPAQYLYKMDDTAYFMNTDTYDQYEIPVANVEQEL
                     LYILENSDVKIQFYGSEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATLETGLVV
                     NVPDFIEAGQKLIINTAEGTYVSRA"
     gene            61714..62103
                     /locus_tag="VHC05_000142"
     CDS             61714..62103
                     /locus_tag="VHC05_000142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014335250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEQ5401492.1"
                     /translation="MTTEYIGEIVISPRVLEVITGIATTQVEGVHSLHNKKMADSFNK
                     ASLGKGVYLQTEEDGSVTADIYVYLQYGVKVPTVSMNIQKTVKSAVYDMAEVPISAVN
                     IHVEGIVAEKTPKPDLKSLFDEDFLDD"
     gene            62096..62548
                     /gene="nusB"
                     /locus_tag="VHC05_000143"
     CDS             62096..62548
                     /gene="nusB"
                     /locus_tag="VHC05_000143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antitermination factor NusB"
                     /protein_id="HEQ5401493.1"
                     /translation="MTNSFQNSRRDLRERAFQALFNIEMGAELLAASQFAYGYDKVTG
                     EDAQVLELPIFLLSLVMGVNNHKEELDNLISTHLKKGWSLERLTLTDKTLLRLGLFEI
                     KYFDETPDRVALNEIIEVAKKYSDETSAKFINGLLSQYVSEAPSANKS"
     gene            complement(62689..63654)
                     /locus_tag="VHC05_000144"
     CDS             complement(62689..63654)
                     /locus_tag="VHC05_000144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEQ5401494.1"
                     /translation="MVAKLTDVAALAGVSPTTVSRVINKKGYLSQKTVNKVNKAMREL
                     GYKPNNLARSLQGKSTQLIGLIFPNISNIFYAELIEHLEIELFKQGYKTIICNSEHNP
                     VKEREYLEMLAANQVDGIISSSHNLGIEDYERVEAPIVAFDRNLAPNIPVISSDNFEG
                     GKLAAQTLQKHGCQNIVMITGNDNSDSPTGLRQLGFNYQLKRSAEIIKLPNNLSPVRR
                     EMEIKSILATRKPDGLFVSDDLTAILIMKVAKQLHITIPEDMKVIGYDGTTFIQQYVP
                     QLATIRQPIDEIAKLSVEILIKKIKKEKTSKDYILPITLLPGASI"
     gene            complement(63659..65098)
                     /locus_tag="VHC05_000145"
     CDS             complement(63659..65098)
                     /locus_tag="VHC05_000145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054964.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HEQ5401495.1"
                     /translation="MDLPQAIRYRPYKEWSSKDYQAITEKMAQSPWHSQFHVEPKTGL
                     LNDPNGFSYFNGRYHLFYQNWPYGAAHGLKQWVHMTSTDLVHFTETRSRLLPDHAHDS
                     HGAYSGSAYAIDDKLFLFYTGNVRDANWVRTPLQVGAWMDKQGNISKIPQVLIEQPDD
                     VTEHFRDPQLFSYQGQFYAIIGAQGLDGKGKIKLYKAVDNHVDNWRFIDDLDFDDSGT
                     EYMIECPNLVFVDDKPVLIFSPQGLAKADLDYQNIYPNTYKIFESFNPETGQLLGGGA
                     LQNLDFGFEAYATQAFSSPDGRVLAVSWIGLPDIDYPTDRYDYQGALSLVKELRIKDG
                     ILYQTPVSALQNLRGPAELFHNKIDSSNCYELELTIPGQKKLDLLLFADQKGNGLRLK
                     VDTTKGQLSIDRSRAGVQYAQDYGTVRSCQIPQSHVTLNVYVDNSILEIFINQGQKVL
                     TSRVFPTQGQTGIQVVEGQAFGHYYEMRY"
     gene            65340..67223
                     /locus_tag="VHC05_000146"
     CDS             65340..67223
                     /locus_tag="VHC05_000146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS beta-glucoside transporter subunit IIBCA"
                     /protein_id="HEQ5401496.1"
                     /translation="MDNRQIATEVIEALGGRENVRSVAHCATRLRVMVYDEGKIDKEK
                     AEAIDKVKGAFFNSGQYQMIFGTGTVNNIYDEVVALGLPTSSTSEQKAEAGKQGNIFQ
                     RAIRTFGDVFVPIIPAIVATGLFMGVRGLVTQPAIMDLFGVHEHGENFLMYTRILTDT
                     AFVYLPALVAWSAFRVFGGNPIIGIVLGLMLVSNELPNAWVVASGGDVKPLTFFGFVP
                     VVGYQGTVLPAFFVGLVGAKLEKWLHKKVPEALDLLVTPFLTFAIMSILGLFVIGPVF
                     HSLENLVLAGTQAVLHLPFGIAGLIVGGIQQLIVVTGIHHIFNFLEAQLIANTGKDPF
                     NAYLTAAIAAQAGATLAVAVKTKSPKLKGLAFPSTLSALLGITEPAIFGVNLRYPKVF
                     VSGLIGGALGGWVAGLFGIAGTGFGITVLPGTLLYLNGQLLQYLVTMLVGLGVAFAIA
                     YTWGYQDRETLPLPAVEVDQTADQPALAEETLYSPLNGTVVDLAAVSDPVFSSGAMGQ
                     GLAIKPEDNTLYSPVDGKVEIVFETGHAYAITSSQGAEVLLHIGIDTVSMAGDGFESL
                     VAVGQAVKRGDLLGHFDPSKIAEAGLDDTTMMIVTNSADYQSVDILAQGHILIGDQVA
                     LIK"
     gene            67454..70468
                     /locus_tag="VHC05_000147"
     CDS             67454..70468
                     /locus_tag="VHC05_000147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endo-beta-N-acetylglucosaminidase"
                     /protein_id="HEQ5401497.1"
                     /translation="MDKHLLVKRTLGCVCAATLMGAALATHHDSLNTVKAEEKTVQVQ
                     KELSSIDSLHYLSENSKKEFKEELSKAGQESQKVKEILAKAQQADKQAQELAKMKIPE
                     KILMKPLHGPLYGGYFRTWHDKTSDPTEKDKVNSMGELPKEVDLAFIFHDWTKDYSLF
                     WKELATKHVPKLNKQGTRVIRTIPWRFLAGGDNSGIAEDTSKYPNTPEGNKALAKAIV
                     DEYVYKYNLDGLDVDVEHDSIPKVNGEASDENLKRSIDVFEEIGKLIGPKGVDKSRLF
                     IMDSTYMADKNPLIERGAPYIDLLLVQVYGARGEQGEFQNDTKLVTETPEERWQGYSK
                     YIRPEQYMIGFSFYEERAGSGNLWYDINSRKDDDKANGINTDITGTRAERYARWQPKT
                     GGVKGGIFSYAIDRDGVAHQPKQIAEKDKQNVKNNQPQIPEITDNIFHSDYSVSKALK
                     TVMLKDKSYDLIDEKDFPDKALREAVMAQVGTRKGDLERFNGTLRLDNPAIQSLEGLN
                     KFKKLAQLDLIGLSCITKLDQSVLPANMKPGKDTLETVLETYKKDNKEEPATIPPVSL
                     KVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLDLAPGTENRQIFDTML
                     SIISNHVGSNEQTVKFDKQKPTGHYPDTYGKTSLRLPVANEKVDLQSQLLFGTVTNQG
                     TLINSEADYKAYQNHKIAGRSFVDSNYHYNNFKVSYENYTVKVTDSTLGTTTDKTLAT
                     DKEETYKVDFFSPADKTKAVHTAKVIVGDEKTMMVNLAEGATVIGGSADPVNARKVFD
                     GQLGSETDNISLGWDSKQSIIFKLKEDGLIKHWRFFNDSARNPETTNKSIQEASLQIF
                     NIKDYNLDNLLENPNKFDDEKYWITVDTYSAQGERATAFSNTLNNITSKYWRVVFDTK
                     GDRYSSPVVPELQILGYPLPNADTIMKTVTTAKELSQQKDKFSQKMLDELKIKEMALE
                     TSLNSKIFDVTAINANAGVLKDCIEKRQLLKK"
     gene            70732..71616
                     /locus_tag="VHC05_000148"
     CDS             70732..71616
                     /locus_tag="VHC05_000148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEQ5401498.1"
                     /translation="MGKLYGSIEAGGTKFVCAVGDEEFTVVDKTQFPTTTPEETIART
                     IAYFKAFEADLAGIAIGSFGPIDIDPSSETYGYITTTPKSGWANVDLLGQLSAAFKIP
                     FDVTTDVNSSAYGEVLARPGVESLVYYTIGTGIGAGAIQHGHFIGGLGHTEAGHTYVM
                     PHPDDMAKGFLGVCPFHKGCLEGMAAGPSIEARTGVRGERLDQEADVWDIQAFYIAQA
                     ALQATMLYRPQVIVFGGGVMAQEHMVLRVHDKFTTLLSGYLPVPDLTDYIVTPAVADN
                     GSATLGNFALAKLAAQGK"
     gene            71711..72664
                     /gene="manA"
                     /locus_tag="VHC05_000149"
     CDS             71711..72664
                     /gene="manA"
                     /locus_tag="VHC05_000149"
                     /EC_number="5.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase, class I"
                     /protein_id="HEQ5401499.1"
                     /translation="MSEPLFLKSTMHDRIWGGTKLRDVFAYNIPSDTTGEYWAISAHP
                     NGVSTVTNGRYQGQPLNTLYAQEPALFGNPKEEVFPLLTKILDANDWLSVQVHPDDAY
                     GREHEGELGKTECWYIISAEEGSEIVYGHQAKSKEDLRAMIEAGAWDDLLTRVPVKAG
                     DFFYVPSGTMHAIGKGILILETQQSSDTTYRVYDFDRKDVNGNLRDLHIEKSIDVLTI
                     GKPENSVPATMVLDNMVATTLVSTPFFTVYKWVTSQMVDMKQAAPYLLVSVLKGQGKL
                     YVDQKAYELEKGMHFILPNDVKSWSFDGQLEMIVSHPNQLV"
BASE COUNT        22477 a        12587 c        15298 g        22366 t
ORIGIN      
        1 gaatgccata gtcatccgtt gtgataatgc ttgaaaatag tcagttagta agcgaaaaag
       61 tctaacatta acctttataa attgaaaata actgttagta gactaatgac aggtagatac
      121 tcttaatagc gcgtttgatt tcacgcataa aaagctttaa aaacgcttta aattatgata
      181 aaatgaactg tatcgaaatt attttaagga gaaatgactt aatgtctaca tcatttgaaa
      241 acaaagctac aaatcgtggc gtgattacat ttacaatcag tcaagataaa ataaaaccag
      301 ctcttgataa agcttttaat aaaatcaaaa aagacttaaa tgcaccaggt ttccgtaaag
      361 gacacatgcc tcgtccagtc ttcaaccaaa aatttggtga agaagttctt tatgaagatg
      421 ctttgaatat tgtattgcca gaagcttatg aagcagctgt gacggaactt ggtcttgatg
      481 tggttgcaca accaaaaatc gatgttgtgt caatggaaaa agggaaagag tggacacttt
      541 ctgctgaagt tgtgacaaaa cctgaagtga aacttggtga ttataaaaac ctagttgtag
      601 aagttgatgc ttcaaaagaa gtttcagatg aagacgtgga tgctaaaatt gagcgcgaac
      661 gtcaaaacct tgcggaactc attattaaag acggtgaagc agctcaaggt gacactgttg
      721 tgattgactt tgttggttca gttgatggtg ttgagtttga tggcggtaaa ggagataact
      781 tctctcttga acttggttca ggacaattta tcccaggttt tgaagatcaa ctagttggtg
      841 ctaaagctgg cgatgaagta gaagttaatg tcacattccc agaatcttac caagcagaag
      901 atcttgcagg taaagccgct aaatttatga caactattca cgaagtcaaa acaaaagaag
      961 taccagagct tgatgatgag cttgcaaaag atattgatga agatgttgac acacttgaag
     1021 acttaaaagt aaaatatcgt aaagaacttg aagcagctca agaaactgct tatgatgatg
     1081 ctgttgaagg agctgcgatt gaattagcag ttgcaaatgc tgaaattgtt gatttacccg
     1141 aagaaatgat tcatgaagaa gtcaaccgtt cagtgaatga atttatgggc aacatgcaac
     1201 gtcaaggaat ctcacctgaa atgtacttcc aattgactgg tacaactcaa gaagatttac
     1261 ataaccaata ttcagctgaa gctgacaaac gtgttaaaac aaaccttgtt attgaagcaa
     1321 ttgctaaagc agaaggtttt gaagcaacag atagtgaaat tgaacaagaa attaatgacc
     1381 ttgcaacaga atataacatg ccagctgacc aagttcgttc tcttctttca gcagatatgt
     1441 tgaaacatga tattgcaatg aaaaaagcag ttgaagtgat tacaagcaca gcaagcgtta
     1501 agtaatctta ttaaggaaca aaacgtacaa gccggattag aacgtctttc tagtctggtt
     1561 tttctttttc taaagaaata ataaggaatt agttagacgt tattttaatg aattagcttt
     1621 aaagatttgt caagaagaag ttatatgagt tgataaaagt tttgacgaat tacttttttt
     1681 agcgtaaaat ggtagagaat gataaaataa ggagaactgc cttgaaatta gacgtatttg
     1741 caggacaaga aaaaagcgag ctttccatga ttgaagtggc gcgtgccatt ttggaagaac
     1801 gcggtcgcga caatgagatg tactttagcg atttagtcaa tgagattcaa aattacttag
     1861 gaaaatctga tgcaggtatt cgtcatgcat taccattttt ctatactgac ttaaatacgg
     1921 atggctcatt tattcctcta ggtgaaaaca aatggggact tcgttcgtgg tatgctattg
     1981 atgaaattga tgaagaaatt attactctag aagaagatga agatggcgca caaaaacgta
     2041 agaaaaaacg cgttaatgct ttcatggatg gagatgaaga tgctattgat tatagagatg
     2101 atgatccaga agatgaagat ttcacagaag aatcagctga ggttgaatat gatgaagaag
     2161 atccagatga tgaaaaatca gaagtggagt catatgattc agaattgaat gaaattatcc
     2221 ctgaagatga ttttgaagaa gttgatatca atgaagaaga cgaagaagat gaagaagatg
     2281 aagaaccagt tctctaatgt ctttagttca gaaataaaaa tgtaattatc atttgacaaa
     2341 ttgtctatta tagtttatat tattattcgg gcacctcttt aagaggtcag gcaaaagctc
     2401 tctagttaat agggggctat ttttgttttc tagaataatg ccagtttgcc tctatattta
     2461 gaaaactaag gtgataccta accaatgtgg aaccaactaa tagggaatta acaagaaagc
     2521 aatgctttta ttcagcttat ataaaggagt actatgacga aatacatttt tgtaactggt
     2581 ggtgttgtat catcaattgg caaaggaatt gttgcggcaa gtcttggccg attgttaaaa
     2641 aatcgtggac ttaaggtgac gattcaaaaa tttgatcctt atattaatat tgatccaggg
     2701 acgatgagcc cctatcagca tggagaagta tatgtgacag atgacggtgc tgaaaccgac
     2761 ttggatttgg gtcactatga acgttttatt gatatcaatc ttaataaata ttccaatgtt
     2821 acaacaggta aaatttatag tgaagtcctt cgtaaagaac gtaaaggtga gtaccttgga
     2881 gcgactgttc aggtgattcc tcatatcaca gatgccctta aagaaaaaat caaacgcgca
     2941 gcttcaacaa cggactctga tgtaattatt actgaggtcg gggggactgt tggcgatatt
     3001 gaaagtttac cgttcttaga agctcttcgt cagatgaaag ctgatgttgg ttctgaaaat
     3061 gtgatgtata ttcacaccac cttgttgcca tatttaaagg cagcgggtga aatgaaaact
     3121 aagccaacgc aacattccgt taaagaattg cgtggtttag ggattcaacc gaatatgttg
     3181 gttattcgta cggaagagcc agttgagcag gggattaaaa ataaattggc tcagttctgt
     3241 gatgtgaatt cagaagctgt tatcgagtca cgtgatgtag aacacttgta tcaaattcca
     3301 ttgaacttgc aagctcaatc aatggatcag attgtttgtg atcatttgaa attgaatgcg
     3361 ccacaagctg atatgaccga gtggtcagct atggttgaca aggtgatgaa tttaagaaaa
     3421 acaacaaaaa ttgccttggt tggtaaatat gtggaattgc cagatgccta cttatctgtt
     3481 gtggaagcct tgaaacattc tggttatgcc aatgataccg caattgacct aaaatgggtc
     3541 aatgctaacg atgtgacggt ggataatgca gctgacttgt tgggagatgc ggatgggatt
     3601 attgtaccag gtggttttgg tcaacgtggt acagaaggca agatccaagc gattcgctat
     3661 gcccgcgaaa atgatgtgcc aatgcttggt atctgtcttg gcatgcagtt gacttgtgtt
     3721 gaatttgccc gccatgtcct caatatggaa ggtgcaaact cttttgagtt agagccaagt
     3781 actaaatacc ccatcattga tatcatgcgt gatcaaattg atattgaaga tatgggaggt
     3841 acgcttcgtc ttggattgta cccatgtaaa ttgaaaccag gttcaaaagc agcaatggct
     3901 tacaataatc aagaggtggt gcaacgtcgt catcgtcacc gttatgagtt caacaacaaa
     3961 ttccgctcag aatttgaagc agctggtttt gttttctcag gggtatcacc tgacaaccgc
     4021 ttagttgaaa ttgtagaatt gaaagagaaa aaattctttg tagcagctca ataccaccca
     4081 gaattgcaaa gccgtccaaa tcgtcctgag gagctataca ccgcttttgt tacagctgct
     4141 attaaaaata gcaattagtg gttttaaggg taagtttgtg gcattctgct tggctggcag
     4201 atactgataa agattactag ctattagagg gatcttttct ataaaaatag cattagaaaa
     4261 agaaaaacgt gatattttta ggttagcact ttctttttca gtcatttttt tgtaaaatac
     4321 ttggtatgaa aactattcga atagcaaagt atttaggaat tctattcctt ttgataactc
     4381 ttattagcgt aggtgctagt ttttatttct ttcatgttgc acaaataaga gaagagaaat
     4441 cgtttattaa taataagaaa cggagtacga ataatccatt atacccagct gaacagtctt
     4501 ttgacgcttt accttacgaa aaacgtcaac taacaaatcg tgggttaaaa caagtggggt
     4561 ggtacttacc agctgctcaa aaaacaaaaa agacagctat tgttgttcat ggttttacga
     4621 atgacaaaga agatatgaag ccatatgcca tgctttttca tgatttgggc tataatgtct
     4681 taatgccaga caatgaggcc catggggaaa gtgaagggaa cttgattggt tatggctgga
     4741 atgaccgcct taatgtcatg gcttggacag accaactgat taaggaaaac cctgaaagcc
     4801 aaatcacact ctttggctta tctatgggtg ctgcaacagt aatgatggca agtggtgagc
     4861 gattgcctgc gcaagtcacc tccctcatcg aagattgcgg ttataccagt gtttgggacg
     4921 aattgaagtt tcaggccaag gctatgtaca acttgcctgc ctttccttta ctctatgaag
     4981 tctctgcctt atctaagatt cgagcaggtt ttagttacgg agaagcgagc tcagtgaaac
     5041 agctggctaa aaataaacgt ccaactttat ttatccatgg tgataaggat gattttgttc
     5101 ctacaaaaat ggtttatgac aattataagg ccacgaaagg tcctaaggaa atcttgattg
     5161 ttaaaggggc aaaacacgcc aaatcctttg aaacaaaccc agaacaatac cagaaaaaaa
     5221 ttgccgcttt tttgaaaaaa gttgagaaat aagtattgac agttaaactc acagttgcta
     5281 taataattta tgttgctgat gagtagcggg gatggcggaa ttggcagacg cgcaggacta
     5341 aggatcctgt gaccgcttta ggtcgtgtgg gttcaagtcc cactctccgc ataatgtaag
     5401 aggtgaatca ttgattcgtc tctttttttg gttaaatgaa ggataagaag gcatagattt
     5461 actggagaaa acttttgata atctgctttt ggaaaacgct ttaagcttgt gaaagactag
     5521 aaatttatgg aaaattgtgc tagaatgaac aatgtaaacg gggagttatc ccgaaaaata
     5581 agaggaggcc ttacaaatgg caatcgtttc agcagaaaaa tttgtccaag cagctcgtga
     5641 aaacggatat gctgttggtg gatttaacac aaacaactta gagtggactc aagcaatatt
     5701 gcgtgcagca gaagctaaac aagctccagt tcttatccaa acatcaatgg gtgcagcaaa
     5761 atacatgggt ggttataaag tatgtcaatc tcttattact aaccttgttg agtcaatggg
     5821 tatcactgtt cctgttgcta tccaccttga tcatggtcac tacgaagatg ctcttgagtg
     5881 tatcgaagta ggttacactt caatcatgtt tgacggttca caccttccag ttgaagaaaa
     5941 ccttgctaaa actgcagaag ttgttaaaat tgcacatgct aaaggcgttt cagttgaagc
     6001 tgaagttggt acaatcggtg gtgaagaaga cggtatcatc ggtaaaggtg agctcgctcc
     6061 aatcgaagat gctaaagcaa tggttgaaac cggaattgac ttcttggcag ctggtatcgg
     6121 taacatccac ggtccatacc cagaaaactg ggaaggtctt gctcttgacc acttagaaaa
     6181 attaacagca gctgtaccag gtttcccaat cgtattgcac ggtggttctg gtattcctga
     6241 cgatcaaatc aaagaagcaa tccgtcttgg tgttgctaaa gttaacgtta acactgaaag
     6301 tcaaatcgct ttctctaacg caactcgtga atttgctcgt aactacgaag ctaacgaagc
     6361 agaatatgat ggtaaaaaat tatttgaccc acgtaaattc ttggctccag gtatgaaagc
     6421 tgttcaaggt gctgttgaag aacgtatcga tgttttcgga tcagctaaca aagcataatt
     6481 tagagtatta aacaccctaa agccctcttg agggcttttt tagatataat tgacacccta
     6541 aaatggatac cagtttctgt gaaataatct ttgattgtga acaaacaaag cataatttag
     6601 agtattaaaa tctggaccct gctatctatg gtaagtcttt ttgttattgt taaagaggtt
     6661 aagcgtaatg ttaatatgtt ttagctaaaa aatgtagtga aaaatgagta cgtagactat
     6721 tgtaatagta attccgtaaa attgttgaaa aagaaaatgg gaaatacctt gtcaaattaa
     6781 gcaccctatg atagaataga taggtatgtg gtgctagcac atccgtaaac atattctacg
     6841 taggaggaaa cagatcaaaa tggctaaagt atgttatttt acaggacgta aaaccgtttc
     6901 tggaaacaac cgttcacacg cgatgaacca aacaaaacgt acagttaaac caaaccttca
     6961 aaaagttact atccttgttg atggtaaacc taaaaaagtt tgggcttctg ctcgtgcgct
     7021 taaatctggt aaagtagaac gcatctaata gaaataagcc ttagggcttt ttttattagc
     7081 ttatttctat ccataagcta gtcagggtaa taaacgctat cgttaactat tctatctctt
     7141 ttacattact tctaaaatat gataaaatag gatgataaaa actttttgag gtagtaacta
     7201 tgactgtaaa aattaataca aaagatggtc taatcgagct atccgacgat gtgattgcaa
     7261 ctgtcgttgg aggatcagca acggaaattt ttggtgttgt tggaatggcc agcaaaagtg
     7321 caataaaaga caattttcaa tcactacttc gcaaagaaaa ctacgctaag ggtgttgtag
     7381 taaaatcaac agatctgggt atttctgttg atgtctacac tgtgatgagt tatggtgtga
     7441 aaatcagtga agtctctaaa aatatccaag aacgcgtgaa atttaacctt gaaagtcagc
     7501 ttggtctcac tgctgatatg gtcaatgttt acgtgcaaaa tattaaggtt gtaggagaaa
     7561 attagtgtca aatattacaa caagcttatt ccaagaaatg gtccaagcgg cagcgactcg
     7621 ccttggcaaa caagcagaat atgttaattc cttaaatgtt tttcctgttc cagatggtga
     7681 tacaggaaca aacatgagca tgactatgga caatggtgcc aaggaagttg ctgataaacc
     7741 tgcgtcaact gtgggagaag ttggacaaat gttatcaaaa ggtcttttga tgggagcgcg
     7801 tggaaattct ggagttatta cttcacaact ttttcgtggt tttggtcaaa gcattaaggg
     7861 aaaagatgag ctgacaggta aagatttggc acaagccttt caagtgggtg tagaagttgc
     7921 ctacaaagca gtgatgaaac ctgttgaagg aacaatttta actgtttctc ggggtgcagc
     7981 gactgctgcc ttaaaaaaag cagaccttac agacgacgcc gtggaagtca tgcaagctgc
     8041 tttagatggt gccaaaggtg cccttgctaa gactcctgat ttacttcctg ttcttaaaga
     8101 agttggtgtg gttgattcag gcggtcaagg tcttgtcttt atctatgaag gtttcctatc
     8161 tgctttgaat ggcgactatg tgacttcagc agactttaaa gcgactcctg ctaacatgtc
     8221 tgaaatgatt aatgctgagc atcacaaatc cgttgttggt catgtggcta ctgaagacat
     8281 tacctacggt tattgtactg aaatcatggt tgcccttaaa caaggcccaa cctatgtgaa
     8341 agaattcaac tatgatgagt ttcaaggcta ccttagtggc cttggtgact cgctgttagt
     8401 ggtcaatgat gatgagattg ttaaagttca cgtccatact gaagaccccg gacttgtgat
     8461 gcaagaaggt cttaaatatg gttcgctcat caagattaaa gtggacaata tgcgtaacca
     8521 gcatgaagca caggttcaaa agactgatgt cgaaaaaaac aaggctgaag taaaagactt
     8581 tggcttgatt gcagtagtag ctggagaagg tttatctgaa attttcaagg cgcaaggtgt
     8641 tgattacgtg atttctggtg gtcaaaccat gaatccatct acagaagata ttgttaaagc
     8701 tattgaagca gttaatgcca aacaagtcat tatcttgcca aacaataaaa atatctttat
     8761 ggctgcccaa tctgctgcag aagtggtgga tattccggct gctgttgttg caacacgtac
     8821 tgttccgcaa ggatttacca gcttgttggc ctttgatcct tcaaaatctt tagaggacaa
     8881 tgtagcagat atgtcaacta gtctttctga cgtggtcagt ggaagcgtta ctttggcagt
     8941 ccgtgacacc accattgatg gtttagaaat ccatgaaaat gatttcttgg gaatggttga
     9001 tggtaaaatc atcgtttcaa acccagacat ggaagcaact ctaaaagctg cctttgaaaa
     9061 gatgattgac gaagatagcg agattgtgac tatctttgtt ggtgaagaag gtgaccaaga
     9121 cttagcagaa gaacttgctg ggtatttagg agagacttac gaagatgtgg aagttgagat
     9181 ccatcaagga gatcagcctg tttacccata tctcatgagt gtagaataat agaatacaat
     9241 aaaaaaagag gagttaggca aaggtctgac tctttttgtc tatattgatg tcgtaatgag
     9301 tggttttagt gatggtaagc ccctaaaaaa tgagggtaat ccatcacaaa gctaatggtt
     9361 acgatttaat ttgacaaaac ctagaaaaac attataattg tattataaca ataagtcaag
     9421 agctgaaaac ggttcagttc taagacatta caaggaggag attttatgtt agaaccattt
     9481 atctttattg cttttggggt tattataatc ctagctattg ttgccagcac cctttatgtg
     9541 gttcgccaac aatctgttgc catcgtggaa cgttttggta ggtaccaaaa aacagccact
     9601 agtggtattc atatccgact tccgtttggg attgacaaaa ttgctgcgcg tgtgcagctg
     9661 cgtcttttac agtcagaaat catcgttgaa accaaaacca aggacaatgt gtttgtgacc
     9721 ttgaatgttg ccactcagta ccgtgttaac gagcaaaatg taacggatgc ttactataaa
     9781 ttaatgaaac ctgaatctca aatcaagtct tatattgaag atgccttgcg gtcatccgtg
     9841 ccgaagttga ccttagacga attgtttgag aaaaaagatg aaattgcctt ggaagtacaa
     9901 catcaagtgg cagaagaaat gtcaacctat ggatatatta ttgtcaaaac cttgattacc
     9961 aaggtggagc ctgatgctga agtcaaacag tcaatgaatg aaatcaatgc ggctcaacgc
    10021 aaacgtgtag ctgctcaaga gttggcaaac gcagataaaa ttaaaattgt gacagcagca
    10081 gaagcagagg ctgaaaaaga tcgattgcac ggggtaggga ttgcccaaca gcgtaaggcc
    10141 attgtggatg gtttggcgga gtctattcaa gagcttaaag aagcgaatat ttccttaaac
    10201 gaagaacaaa tcatgtccat tttgttgacc aaccaatacc tggataccct caataccttt
    10261 gcggcaaaag gaaaccaaac cctttttcta ccaaatacac caagtggggt agaggatatc
    10321 cgtacacaag ttttatctgc ccttaaaaca aaataacgtg taaaagcttg gctaaaaagt
    10381 tgctcaatac tggatttagc agaaggctat tataccttgt gaagtggcaa acgacgaaat
    10441 gaatacatta cttttattgg agaaatgaaa gtaaaaaaag cctttttcat gattaacaac
    10501 atagtattga ttaaatgtta agttgtattg acttttaaat taaataagtt taaaatcaac
    10561 ttaataagca aaaaggagat tttcaatgaa atccaaaaaa gttgttagtg ttatatcact
    10621 taccttatcc ctttttttgg tgacaggttg tgctaaagtt gataacaaca aatcagttaa
    10681 tcgtaagcct gctactaaac aaacctataa tagctatagt gatgaccaat taagatcgcg
    10741 tgaaaatacc atgtctgttt tatggtacca gcgagctgcg gaaactcaag cgctttattt
    10801 acaggggtat cagttagcaa cggatcgctt aaaagaacaa ctcaataaac caacggataa
    10861 accttattcg attgtattag atattgacga aacagttctt gataatagcc cttatcaagc
    10921 taaaaatgtt ttggaaggaa caggatttac acctgaaagc tgggattatt gggtacaaaa
    10981 gaaagaagca aaaccggttg ctggtgctaa agactttttg caatttgcag accaaaatgg
    11041 tgttcaaatt tactacattt cagacagatc aactactcaa gtagatgcta caatggaaaa
    11101 tctccaaaaa gaaggtattc cagtacaagg tcgtgatcat cttctattct tagaaaaagg
    11161 cgtaaaatca aaggagagtc gtcgtcaaaa ggtcaaagaa acaactaatg taacgatgct
    11221 atttggtgat aatcttctag attttgctga tttttcaaaa aaatctcaag aagatagaac
    11281 agctttatta tcagatttgc aagaagagtt tggaagacgc tttatcattt tccctaatcc
    11341 tatgtatggt tcatgggaag gtgccattta taaaggtgaa aagctggatg tgcttaagca
    11401 actagaggaa cgccgtaaaa gtttaaaaag ctttaaataa agtaattgaa aaagaggtgc
    11461 aaaagaaaat gtaacctctt tttaagtact attattttct gaaaataggg ttaatgactg
    11521 aaaaaaatgt tgattttgtg aaatgattat tttattattt tcatatttta tctttatgct
    11581 aggaattgtg gtataatgga ggagtataaa aaatattaag gagtctattc acatggctaa
    11641 attgactgtt aaagacgttg atttgaaagg taaaaaagtc ctcgttcgtg ttgactttaa
    11701 tgtgcctttg aaagacggcg ttatcactaa cgacaaccgt atcactgcgg ctcttccaac
    11761 aatcaagtat atcatcgaac aaggtggtcg tgctatcctc ttctctcacc ttggacgtgt
    11821 taaagaagaa gctgacaaag aaggaaaatc acttgcaccg gtagctgctg atttagctgc
    11881 taaacttggt caagatgttg tattcccagg tgttactcgt ggttcaaaat tagaagaagc
    11941 aatcaatgct ttggaagatg gacaagttct tttggttgaa aacactcgtt ttgaagatgt
    12001 tgacggtaag aaagaatcta agaatgacga agaacttggt aaatactggg cttcacttgg
    12061 agatggaatc ttcgttaacg atgcatttgg tacagcacac cgtgctcacg catcaaacgt
    12121 aggtatttca gcaaacgttg aaaaagctgt agctggtttc cttcttgaaa acgaaattgc
    12181 ttatatccaa gaagcagttg aaactccaga acgtccattc gtagctattc ttggtggctc
    12241 aaaagtttct gataagattg gtgttatcga aaatcttctt gaaaaagctg ataaagttct
    12301 tatcggtggt ggtatgactt acacattcta caaagctcaa ggtatcgaaa tcggtaactc
    12361 acttgtagaa gaagacaaat tggatgttgc taaagacctc cttgaaaaat caaatggtaa
    12421 attgatcttg ccagttgact cgaaagaagc aaacgcattt gctggttaca ctgaagttcg
    12481 cgacactgaa ggtgaagcag tttcagaagg cttccttggt cttgacatcg gtcctaaatc
    12541 aatcgctaaa tttgatgaag cacttactgg tgctaaaaca gttgtttgga acggacctat
    12601 gggtgtcttt gaaaaccctg acttccaagc tggtacaatc ggtgtcatgg acgctatcgt
    12661 taaacaacca ggcgttaaat caatcatcgg tggtggtgat tcagcagcag ctgctatcaa
    12721 ccttggccgt gctgacaaat tctcatggat cagtaccggc ggaggcgcta gcatggaact
    12781 tctcgagggt aaagtattac caggtttggc agcattgact gaaaaataat agtcattata
    12841 atatatagta aagggcatgc tgatgcatgt ctttttttag ttgatcatgt acagttattg
    12901 aactttccct aacttcactt atcatttact agtttttaga tatagtggta tttggctgac
    12961 actgcaattt tcaaaagttt atgacgattt catatcaatt ggtttataaa agatatccta
    13021 atcataaata aaacgtttac caaaagggtt ttatggattg atatgttaaa atagatagtg
    13081 aagggatagg tatgaaaacg ttaagaaaat tattatctaa ttacaagttt gatattaaaa
    13141 agtttaaatt gggaatgaga acattgaaaa caggcttatc ggtcttttta gttttattgg
    13201 tttttcattt atttggttgg aaagggctcc aaattggtgc tctaactgct gtatttagtt
    13261 taagagaaga ctttgataaa agcgtacact ttggcttttc tagaattatt ggtaatagta
    13321 taggtggcct actctcctta gtattttttg cattcaatga gatatttcat caagcttttt
    13381 gggttacttt attaattgtt cctatttgta ccatgttatg tatcatggtt aatgttgcat
    13441 gtaataataa atcaggtatt attggagcag tggctgctct tttgattatt acactgtcta
    13501 ttccaacagg acaaacgttt atttatgtga cttcgcgggt atttgaaaca ttttgtggcg
    13561 tctttgtagc tattttagtt aatactgatg ttgaacttat taaaaataaa tggtttaaca
    13621 aaaaacacag tgatgttaga taatataaca tatatacttg acaggttatt tttttcagcc
    13681 tataataagg aagatgaaag gagtttgtca tgaaagaaaa agaacttaga cgctcaatgg
    13741 ctgtttttcc tattggaacg gtgatgacat taacagatct ctctgcgaga caaattcgct
    13801 attatgaaga tcaaggttta attaagcctg aacgaacgca agggaatcgg cgtatgtttt
    13861 ccttaaatga catggaccga cttttggaaa ttaaagattt tttgtctgag ggattaaata
    13921 ttgcagctat taaacgcgaa tatgtcgagc gtcaaggtaa gttaatgcaa aaacaaaaag
    13981 ctctaacaga tgcagatgtc agacggatct tacatgatga aatgctgaca caaagcggtt
    14041 tttctactcc ctcacagcat attggtaatt ttcgtattta agatataaat tgtataaaat
    14101 ttaaaggaga cctatttaat ggcaatcaca gtagctgaca ttcgtcatga agtcaaagaa
    14161 aaaaatgtaa cgtttcttcg cttgatgttc actgatatca tgggcgttat gaaaaatgtg
    14221 gagattcctg caacgaaaga acagttagac aaagtattgt ctaacaaggt tatgtttgat
    14281 ggttcatcta tcgaaggttt tgtacggatc aatgagtcag atatgtacct ttaccccgat
    14341 ttagacactt ggattgtttt tccctgggga gatgaaaatg gagcagttgc aggtttaatt
    14401 tgtgatattt atacagcaga aggaaagcct tttgcaggag atcctagagg aaatttaaaa
    14461 agagccctga aacacatgaa cgagatcggc tacaaatcat ttaatcttgg gccagaacca
    14521 gaatttttcc tttttaagat ggatgataaa ggtaatccga cacttgaagt taacgataat
    14581 ggtggttatt ttgatttagc gccaattgac ttagcagaca acacgcgccg tgaaattgtg
    14641 aatattttaa cgaaaatggg ttttgaagtg gaagctagtc atcatgaagt ggctgttggt
    14701 caacatgaga ttgattttaa atatgcagat gttttgaaag cttgtgataa tattcaaatt
    14761 tttaagctag ttgtaaaaac gattgcccgt gaacatggac tttatgctac ttttatggct
    14821 aaaccaaaat ttggaatagc tggatcaggg atgcactgta acatgtcttt gtttgataac
    14881 caaggtaata atgcttttta tgatgaaact gataagcgag gaatgcagct atcagaagat
    14941 gcttattatt tcttgggagg actaatgaag catgcttata actacactgc tatcactaac
    15001 cctacagtga attcttacaa acgattagtt ccgggttatg aggcacctgt ttatgtcgct
    15061 tgggctggaa gtaatcgttc accgcttatc cgtgttccag catcacgtgg tatgggaacg
    15121 cgtttggagt tacgttcggt tgatccgaca gctaatcctt atttagcctt ggctgttctc
    15181 ttggaagctg gattagatgg tatcattaac aaaattgaag ctccagaacc cgttgaagct
    15241 aacatttata ccatgacaat ggaagaacga aatgaagcag gcattattga tttgccatca
    15301 acgcttcata atgccttaaa agctcttcaa aaagatgatg tggtacaaaa ggcactagga
    15361 taccatatct acactaattt cttagaagca aaacgaattg aatggtcttc ctatgcaact
    15421 tttgtttctc aatgggaaat tgaccattat attcataact attagagtta tcaggacctg
    15481 ctcaagttga gtgggtcttt tggatgagct attgtatttg agctagcaag ctattattag
    15541 ctgatcggac accaattgat tttccattat agaaaactaa aaaccagtcc atgttctatg
    15601 aggactggtt tttagtttga taattatctg aactagaact gatatgttaa agatatagac
    15661 agatagtatt aagaaatgag tcttatttga ttttagtgct tatcaggtgt taagaccatc
    15721 ggaattataa ttggttcacg ctcagtcttt tcatacaaga atggacgaag agcattgacg
    15781 atagcaccgt taactgattg gatgctagca tccttatttt ttaaagcaat acggatagcg
    15841 ttaaagagca cacgttggct ttcgcggatc aagtcacctg actcacgcat ataaatgaaa
    15901 ccacggctca gaatatctgg tccagctaaa atcatttgtg tgttaaaatc aacagttgca
    15961 acagctaaga caacaccatc ttctgacaaa tcacggcggt cccgtaaaac ggctgctcca
    16021 atatccccga tgccattacc atccacgtag atgtcttggg cattaaagtg accagcaata
    16081 cgcgcactgt cactggttaa agctagaacg tctccatttt ccataataaa gatattttct
    16141 tttggaatac caatatccat cgccagtcct gcatgaactt tttgcatgcg atactcacca
    16201 tgtactggca tgaaatattt tggtttaatc aaactaagca tgagcttttg ttcttgctgt
    16261 cctccatgac cagaagtatg aatattattg acttttccat gaataacatc aacaccagct
    16321 tcttggatgg tattgattaa tttattgaca cttgtggtat taccagggat tggacttgat
    16381 gagaaaatca cagtatcacc aggctgtaaa gttacttgac gatgagtgcc attagcgata
    16441 cgagcaagtg ctgccataga ctcaccttga ctacctgtac acataattaa aacttcacta
    16501 gcatgaagat ttttaagttc gcttggctca atgaaggtac cttttggaac tttaatatag
    16561 ccaagttcaa taccgttaac aattgctttt tccatagaac gaccaaaaac ggcaatttta
    16621 cgtcccgttt taacagcagc ttctgcagcc tgttgcaaac ggtagatgtt tgaagcgaag
    16681 gaagcaaaaa taatacgacc atgaatacct tcgataattt ttaaaatgga ttggccaaca
    16741 actttttcag agttagtaaa ggttgggatt tcagcattag ttgagtctga taataagcaa
    16801 aggacacctt cttcaccaag cgctgccata cgttgtaaat ctgcaggatc tcctactggc
    16861 gtgaagtcaa atttaaaatc accagtacag ataatcttac cttgaggggt gtggataaca
    16921 ataccgaccg gttctggaat ggaatgagta gtcttgaaga aagtgacgct catgttttta
    16981 aaagttaact cggtgttgtg attgatttcg taaacagttg cttcacgcca aagaccatgt
    17041 tcttccaatt taccacggat aagagcaagt gctaaaggtc ctgcgtagat agggatatta
    17101 gcctgtttga gaagaaatgg aataccacca atgtggtctt cgtgaccatg tgtaataaca
    17161 agagctttta cccggtctaa gttatcgaca atgtaagaat agtctggaat aacgtaatca
    17221 attcccaaaa gatcatcttc tgggaatttg ataccggcat caacgataat gatctcgtct
    17281 tgatactcaa taccataagt attcttccca atctctccca gaccaccaat ggcaaacacc
    17341 ccaacttcat taggttttaa actgatattt gtcatcttag aactccgtta attcaaaaac
    17401 accggtctct ttttcgtaat cgaggtgttt gtcagaaagt agctcgataa attccacgtt
    17461 ataataggtg ttatcttcaa cgagacgacg agccttgata cggccatcga gttcatcagt
    17521 agcatcaata ttaagataga gtgctttagt actttcacga cgtgggcttt gatcctttgt
    17581 ttcttgatag aaaactttat aaatcatttg tcttttattc ctttcgttat gaatcaatta
    17641 tccaaacaat aataaatagg tcaaaaggta ggtgttccat tttgacggtt ttatatgttg
    17701 tcattattgt gtagtagatt aattcctgat tctgtgcaat tattataatt ataccataaa
    17761 cttagctttt agtaaaaaat ttaggtacat ttatggtata gtctaaatca aattaagagt
    17821 cagccttttt gtttatgatt cttaatttgt gttataattg atactagaac ttgcagtaga
    17881 aaggcataaa atgaagacac ttgcatttga tacctcaaat aaaaccttgt cccttgctat
    17941 acttgatgat gagacacttc tagcagatat gacccttaac attcagaaaa atcatagtgt
    18001 tagccttatg cctgctattg attttttgat gacttgtact gatcttaaac ctcaagattt
    18061 agaaagaata gtggttgcaa aaggccctgg atcttacaca ggtttacgag tggcagttgc
    18121 tactgcaaaa acgttagcgt acagtttaaa tattgcattg gtcgggattt ccagtctata
    18181 tgctttggct gcgtctactt gtaaacagta tccaaatact ttggtggtgc cattgattga
    18241 tgctagaagg caaaatgcgt atgtaggtta ttatcggcaa ggaaaatcag tgatgccaca
    18301 agcccatgct tcactagaag ttattataga acaattagta aaagaaggac agctgatttt
    18361 tgttggggag actactcctt ttgctgagca aattcaaaag aaactacctc aggcgatact
    18421 acttccaacc cttccttctg cttacgaatg tggtcttttg gggcaaagtt tggcaccaga
    18481 aaatgtagac gcctttgtcc ctcaatatct caagagagtg gaagctgaag aaaactggct
    18541 caaagataat gagataaaag atgatagtca ctacgttaag cgaatctaat atgaaaacag
    18601 ttgaagaaca agcaaaaaat atttatcagc ttttggaaat ggtttatggc acgtctcctt
    18661 ggactttaga acaagtatta atcgatatac ggcgggatca aacagattat ttcctactat
    18721 atgatcatga taaattgcta ggttttttag ctgttcaaga tttagctggt gaagttgaaa
    18781 tgactcaaat tgctatacta cctagtcatc aaggacttgg gctagcgtct caattgatga
    18841 cgcatttaga tagcattgaa agtgacatct ttttagaggt tagagaatct aatcatagag
    18901 cacagggttt atatcagaag tttggtttta aacttattgg caaaagacca gactactata
    18961 gaaatcctat agaaacagct ttattgatga aacgggaagg aaaacatgac agataggtat
    19021 attttagcag ttgagagttc ttgtgatgag accagtgtag cgattttaaa aaacgaaagt
    19081 accctcttaa gtaatgtcat tgcaagtcag gttgagagcc acaaacgctt tggtggtgtg
    19141 gtgccagaag tagctagtag acaccatgtc gaagtgatta cgacttgctt tgaggatgct
    19201 ttgcaagaag ctggcatcag tgcttcagat ttatcagcag ttgcggtaac ttatggccct
    19261 ggacttgttg gagccttgtt agttggatta gcagctgcga aggcttttgc ttgggcaaat
    19321 catttacctt tgattccggt taatcatatg gcaggtcact taatggcagc gcgtgaacaa
    19381 aagcctttag tttatccttt aatagcacta ttggtttcag gaggacacac agaattggtt
    19441 tatgtcccag agccagggga ttatcatatt attggcgaga cgcgtgacga cgctgttggt
    19501 gaggcttatg ataaagttgg gcgtgtgatg ggcttaacct atccggcagg acgtgaaatt
    19561 gatcagttgg ctcataaagg tcaagatact tatcatttcc ctcgtgctat gataacagaa
    19621 gaccacttag aattttcttt ttcaggactc aaatccgctt ttatcaatct tcatcataat
    19681 gctaagcaaa aaggcaatga actgattcta gaagatttgt gtgcatcttt tcaagcagct
    19741 gttctagata ttttattggc caaaacaaaa aaagctctga gcagataccc tgcaaagatg
    19801 cttgtagtgg ctggtggtgt agcggcaaat caaggattac gagatagatt agcacaagaa
    19861 attacacata tagaagttgt gattcctaaa ctaagactct gtggagataa cgcgggtatg
    19921 attgctttag cagcagctat tgagtatgac aaacagcatt ttgctaatat gagcctaaac
    19981 gcgaagccta gtttagcttt tgaccagttt ccagacagtt ttgtaataaa ctagtcacac
    20041 ttgctagtta gtaagattta taatggataa gaatctccct ttgaaaaaac aacccggtat
    20101 cttggcatac cgggttgtca tgatgataag taattggctt ctatggttac taataattca
    20161 gataattacc tgcaaaataa ttgtctgcct aaggtgaagt aagcttacca gctagcttta
    20221 gtgacgccag gaagctgtcc tttgtgagct aagtcacgga aattgatacg gctaacacca
    20281 aacttacgca tgtaagcatg aggacggccg tcaattttgt cgcggttctt caagcggttt
    20341 ggatttgaat cacgaggcaa tttgcgcagt gattcataat cgcccttcgc ttttaagtca
    20401 cgacgaaggt cagcgtactg ttcaatcagt tggagctgct tttggtattt agcaattttt
    20461 gacttttttg ccattgcttt ctccttctta atatttaata acctcagagt cgttatcagc
    20521 gctctgaatc cacttaactg gtatttaact ggttaagtgg atatataatc attatacaat
    20581 aaataaaagc aaaagcaaat aaaaaaatta actagttatc ttttttagcc ataatatcaa
    20641 aaaactccac atctaagtgt gggagtcagg tattaataac tgtttaaagg tgtttaatga
    20701 gtgtcgcttt ggcaactttg agattgaact tttaagtcaa ataaatcagc aggaacgtag
    20761 tgtttggttg agaccaagat gtctttacca ttgtagagag tttcttggat taaaataaaa
    20821 gcactatttt ctgatagagt atacttagtt gctgtgtaat tgccagtctt ggtatagccg
    20881 atttggttgc aggaatgaga agctttacca gattcataga ttttctcttc taagaaagta
    20941 agaaggggct cttcttgatt gagatttata gcatatttgg aaataacctc aatagggata
    21001 aaagataaac tataagcaat agctttattt tggctatgat accagcgatc aacaataatc
    21061 acaacaggag tttcttgctt tagggatgct gtaatggcaa cagtgggcac ttcaatccga
    21121 tattccaatt caacctttgt gatttcagat gataggcttg catatatggg gtgttgaaga
    21181 tattcgaaac cttggtgata tttagtttca ggagtcttga gtataaaatt tccctttcct
    21241 ctgatatttt ttatgagatg atcctcttgg aggagggcta gggatttacg cagtgtcatc
    21301 cgactgacat tgagctgtct agcaagttca ggttctgatg gcagttgcat gccaggacta
    21361 tatgtaccat cttgaataag ttgaaaaata gtattatata cttgcacatg tttaagtttt
    21421 ttgagttttt tggttaagtc gttagtagac atatcactta cctcatttaa taatctttag
    21481 tggagtttaa cttgtctaaa aactatttta gcactaacag tattccttga ttagaattgt
    21541 acccatctat agtgttagta tctcacaccc aggtactttt tgtcaaaaaa gagatgaaaa
    21601 acaccttaaa aaagcgttta caaaatagag tgtgtgtgat actatacaag tgtatcaaaa
    21661 attagacaag taaaatacag gaggttttta acatgcaaaa ttattcaggt gaagtcggat
    21721 tgcaatatca cctacagatt cgtccaggtg atgtaggtcg ttatgttatc atgccaggtg
    21781 atccaaaacg ttgtgcaaaa attgcagaac attttgataa tgcagttctt gtagcagaca
    21841 gccgtgaata tgttacgtat acaggtacat taaacggtga aaaagttagt gttacttcaa
    21901 ctggtattgg tggtccatca gcgtctattg cgatggaaga attgaaactc tgtggcgctg
    21961 atacctttat ccgtgttgga acatgtggtg gtattgacct tgatgttaaa ggcggagaca
    22021 tcgttattgc aactggagct atccgtatgg aagggaccag taaagaatat gctccgattg
    22081 aatttcctgc tgtagctgac ttggaagtga caaatgctct agttaatgca gctaaaaagc
    22141 ttggttatac aagtcacgca ggagtagttc aatgtaaaga tgcattttac gggcaacatg
    22201 agccagaacg tatgccagtt agttatgaat tattaaataa atgggaagca tggaaacgtc
    22261 tgggaacaaa agcgtctgaa atggaatctg cagctctttt tgtagcagca agtcatctag
    22321 gagttcgttg tggatcagat ttccttgttg ttggtaatca agaacgcaac gctttgggta
    22381 tggataaccc aatggctcat gatacagaag cagctattca agttgctgtt gaagcactcc
    22441 gcacacttat tgaaaatgat aaatcacaat aagcgaggtt ttggaagtca tcatgcaatt
    22501 tatttatagt attattggta ttttattggt attaggaatt gtgtatgcaa tttctttcaa
    22561 tcgtaagagt gtttctctaa gtttaattgg aaaagctctt atcgttcaat tcattattgc
    22621 gctaatctta gtacgtatcc cactaggcca acaaattgtt agtgttgttt caactggagt
    22681 tactagcgta atcaactgtg gtcaagctgg tttaaatttt gtgtttgggt cattagcaga
    22741 tagtggcgca aaaactggtt ttattttcgc tattcaaacg cttggtaata ttgttttctt
    22801 atctgcccta gttagtctac tttattatgt aggaatcctt ggatttgtag taaaatggat
    22861 aggtaagggc gttggtaaaa ttatgaaatc ctcagaggtt gagagttttg ttgccgtagc
    22921 taatatgttt cttggtcaaa cagacagtcc aattttggtt agcaaatacc taggtcgtat
    22981 gactgatagt gagataatgg ttgtgttggt atcaggtatg ggaagtatgt cagtttctat
    23041 tcttggtggc tatattgcat taggcattcc aatggaatat ctcttgattg cttcaacaat
    23101 ggttcctatt ggcagtattc tcattgctaa aatcttattg cctcaaacag aacctgttca
    23161 aaaaattgat gacattaaga tggataataa aggtaataac gccaatgtga ttgatgcaat
    23221 cgctgagggt gcaagcacag gtgcacaaat ggctttctca attggggcta gtttgattgc
    23281 ctttgttggt ttagtttctt tgattaatat gatgttaagt ggattgggaa ttcgcttaga
    23341 acaaatcttc tcatatgttt ttgctccatt tggttttctt atgggatttg accacaaaaa
    23401 cattcttcta gaaggaaacc ttcttggaag taagttgatt ttaaatgagt ttgtttcgtt
    23461 ccaacaattg ggtcacctaa tcaaatcttt agattatcgt acagcattgg tagcaactat
    23521 ttcactctgt ggttttgcta atttatcaag tttaggtatt tgtgtttcag gtattgctgt
    23581 tctttgcccg gagaaacgta gcaccctagc tcgacttgtt ttccgtgcaa tgattggtgg
    23641 tattgctgta agtatgctta gcgcctttat cgtcggtatt gtaactctat tctaaacgtt
    23701 gacaaaagaa agaaggatag taacgtggaa gtaaaagata ttttaaaaac ggtagaccat
    23761 actttgctag caacaacagc aacgtggcca gaaatccaaa caattttaga tgatgccatg
    23821 gcttatgaaa cagcttcagc atgtattcca gcctcttacg tcaaaaaagc agcagaatac
    23881 gtttcaggta aattagctat ttgtactgtt attgggttcc caaatggcta tagtacaact
    23941 gcagcgaagg tttttgaatg tgaagatgct attaaaaatg gtgctgatga aattgacatg
    24001 gtcattaatt tgacagacgt taaaaatggg gattttgata ctgttgaaga agaaattcgt
    24061 caaatcaaag ccgcatgtca agaccatatc ttaaaagtta tcgttgagac atgtcaatta
    24121 actaaagaag aacttatcga actttgtgga gttgtcacac gttcaggtgc agactttatt
    24181 aaaacctcta ctggtttttc gacagcaggt gctacatttg aagatgttga agtgatggca
    24241 aaatatgtcg gcgaaggtgt taaaattaag gcagcaggtg gaatctcatc attggaagat
    24301 gctgaaacat ttattgcttt aggagcttca cgcttgggta ctagccgtat catcaagatt
    24361 gttaagaacg aagctacaaa aactgatagc tattaactta atcataccga ttcagcctga
    24421 gactaaaaca aaaaactcat gtaataggag ttaaaaagcc tactatctta gtgataatag
    24481 gcttttttag ctatgaagac ttccctgcga tccatcctga acaaagagct gaggtaatat
    24541 taaaccctcc ggtgtgagca ttaatatcta agacctctcc agcgaaatac aggccaggaa
    24601 ctttcttgct ttccaaggtt ttagggttga tttcttttaa atctacgcct cctttggtca
    24661 caaatgattt agccaaagac atttttcctg taatgggtat ctggaggtgt ttgagtttat
    24721 caagcaattc cttttcttgt tttggagaga gttgtttgac cttttcgggg taattttctg
    24781 ataaaaaatc agctactcgt tcaggcagta ggcctttaag agcatttttg atgtttttat
    24841 cacgttgatc actcagataa gcggttaagt catctgttga taagtgtggc aaaaagtcca
    24901 gctctgcaat ttccccacct ttcacaaaag aggacagacg aagagctgca ggtcctgaaa
    24961 ggccaaagtg ggtgaagagt aagtcgtgtg tgatgacgtg tttgtcataa ctaagagtaa
    25021 cgtcgtctag ggaaatacct tgcaagactt tgtgaggaaa atcagttaac agagggctct
    25081 cagcagcttc taaatcagtc acggtcagtt taaaatgccg tgcaatatca tgtccaaaac
    25141 ctgttgaacc cgttgaagga taggccttgc ctcctgtggt cacaatcaat ttatgacagc
    25201 taaaagtctg gtctgcagat ttgaggtaga agaggtcatc ttgtttttta acggaaacca
    25261 cctcagtgtt ggttagtacc ttgcctccaa gagccttgat ttttttctcc agagcatcaa
    25321 tgattgtcct agatttatct gttgtgggga acatccgtcc atggtcttct tctttgagtt
    25381 tgacgccgtt ttcctcgaaa aaggcaatga tgtcatggtt gtcaaactgg gaaaaaacac
    25441 tatataaaaa gcggccattt ccaggaatgc ctgccataag gtcatcaagg ttaccactat
    25501 tagtgacatt acagcgtcca ccaccggttc ccgctaattt tttacctaag cggcggtttt
    25561 tttcaattaa gagagtttta tagccatagt agctgctgga gatggcggcc atcataccag
    25621 cagggccacc tccaataata atcgtatcgt attgagtcat agccttattt tagcataaaa
    25681 gcgggggatt taatagtcag gtaaatgaac taacctggca taccgttttc tattcatcta
    25741 acaatgtttt caagaaataa ttgatgcctt tagcacgact gaaatgaggt caaattgaca
    25801 gaatactcct attatggtac tatttttaat aagaatattc agtgatagtg ataaagagga
    25861 aaatatggga attgaaaaga cagttagtga actagctgat attttgggag tgagtcgtca
    25921 gaccgtcaat aatcgtgtta agtctttacc cgaagaagat cttgacaaaa atgaaaaagg
    25981 cgttactgtg gttaagcgca gtggtcttgt taagctggaa gagatctata aaaaaacaat
    26041 ttttgacgat gagcctatca gtgaagaaac gaaacaacgt gagcttttag agattcttgt
    26101 ggatgagaag aacactgaaa tcacgcgcct ttatgagcaa ctcaaggcca aagatgctca
    26161 acttgcctca aaagatgagc aaatgcgtgt taaagacgtg cagatcgctg aaaaagataa
    26221 acaattggat cagcagcaac aattaactgc taaagccatg gctgataaag aaaccctaaa
    26281 actagaattg gaagaagcta aagcagaagc caaccaagct cgcttacaag tcgaagaagt
    26341 tcaggctgaa gttggcccta aaaaaggctt tttcacccgc ttgtttgcga aataatcaca
    26401 aaaaatgacg aaggccctat cagggtcttt tttggaggaa aacatgcaac acttagatac
    26461 ttatattgcc tttgatttag aatttaacac tgtcaatgac gttagtcatg tcattcaagt
    26521 atcagcagtc aaatatgacc accataaaga agttgacagc tttgacacct atgtttacac
    26581 agatgttccc ttacagagct ttatcaatgg cctaacagga atcacatctg acaagattgc
    26641 tgcggcacca aaagtagagg aggttatggc tgcgtttaaa aattttgtgg gagagttacc
    26701 attgattggt tataatgctc aaaaatctga cctgcctatt ctagctgaaa atggcttaga
    26761 tttaagggac caataccaga ttgacctctt tgatgaagct tacgatagac gtagcgcaga
    26821 cttaaatggg attgctaacc ttcgtctgca aacagtcgca acctttttag gcattaaggg
    26881 tcgaggtcat aatagcttag aagatgccag aatgacagca gcaatctata agtctttttt
    26941 agaaacagat acaaacaaag catatctcag ccagcaagaa gaggtaacca cagataaccc
    27001 tttcgcggct ttgggagact ttttcgacta aaggctctgc tatttttaaa aaacaaaaaa
    27061 atcctctagg gttagccctt gcttgtaacg ctaggtcatg tgataagcta ggggcatatc
    27121 aagagggagt cgggtgcaca cgagtcgctt ttgatgacta aatggtagaa agaaggtgtg
    27181 gaaatgtctc aattctattc gactggagaa ttggccaact tagctggcgt ttctattcga
    27241 actgtccaat actatgacca acgtgggatt ttgattccga cagcattgac agcaggtgga
    27301 cggcgactct atacggattc tgatttagaa caattacgca tgatttgctt tctgcgcgat
    27361 ttgggatttt ccattgcagg ccatacacca cgaaccagaa agttaacctg ctcccattgc
    27421 catcaaaaat cgtattgctt ggaactggca aaagaggaca ctgtctcaag aggataagca
    27481 ctaactcata aaaaaactag cctgagatcc ttctcaagct agtttttgtt tttttagaat
    27541 ggtaatttac cagcaaaagc gcctaatgtt ttcttagttg tttcatcaat ttgcgtaagg
    27601 gcatcattaa tggcttgagt ggtcatgtct tgaagcgttt ctacatcttc aggatctaca
    27661 acagcttctt tgaagtcaat cccaaccaat tttttatcac ccgtgaaagt ggcagtgaca
    27721 aggtcttgag ctgattttcc agtaaattgc atagcagcca aatctgcttg tttttgttcc
    27781 atttgtttct gaagcttttg tgcctgcttc atcatgtttt gcatattcat cataagacta
    27841 tactctcctt aatttaatac taactattat aacacataaa aagaggcaat aaaaacaatg
    27901 tcagttagta gactagcctg tatcagtaag aaagtcgcta tggataagat agattagtag
    27961 gaagggtctg gctaatgaca gaataagtct agaaatggac tatttttgtc atagactagt
    28021 ccgacttagt ggttatctaa ttcacgatct tctttagctt gttgttctaa aagaatttgt
    28081 gcgaagtcaa cccacttagt gtagttattt tcggataatt gttctgaaat catcgctaac
    28141 tctcgttgtg gcaactgata agagactccc ttactttcta aggttaaatc ttcttccatt
    28201 agggcggtta aactaacatc aaagatagca gcgatatcac ttaatagacc agactttgga
    28261 gtatattttc ctttttccca ctcactgatt gaagaagagc tttttcgtcc taggagatta
    28321 gcaagttcta attgttccat gttctttttt aatctaaggt actttaaatt acttgcaaaa
    28381 aaagttttct tggcggacat atttttctcc ttttctttat ataaaatatg ataccataaa
    28441 agaggttaaa gcaaaaggta tcgtaaaaga tggtctaaaa actctctaaa aacttgactt
    28501 cataaaaacc gaagtttata ataaacttaa catgattaac taatctcatt ttagtgtgga
    28561 gggaaaattg tgaccaaatc aactttaaaa gagttaagaa caacaaagaa aatgacacag
    28621 caggaattgt ctcacttaac aggtatttct gtcagaacga ttgctaggta tgaaaaagat
    28681 actaaaaagc taaggcgagc aaaatatgag aagctaaaag gtattgcaca agcattagcg
    28741 gtttccgttg atgatatttt tttaggaata gattcggaat ttatgaacta agacgatcgt
    28801 tttctgtttg ctattagtaa gaccaattaa caaaaaagtg cttagttata ttgctaagca
    28861 cttttctttg ttaatttgat gctattggca caatcaattg agactgactg agatcgatag
    28921 ttaaagcata gttgctgttg tcacggacag tatgttcaaa atcggttgtg tataagatga
    28981 ctcgaagggt atctcctttt tctagatgat agatggttgg ttgcaaagga agtctaacag
    29041 tcatccattt attattagga atagtttcaa ttgacgacaa attattgcga ttttgtaaat
    29101 tcatgaaacc tttcgaaata acacggtaag aatcttctct aaatggtagc tctttaaggg
    29161 attctctaga gaaattttgc ccattgtcaa tacttgattg ggtgagagca ataggaagat
    29221 cgcccaagcg ttttttctta ccatagtcaa ggatttgtgc agatagaagt cctttatttt
    29281 cacttgattt cacttttaac tgtaggacaa tttcaccgtt aataggtaag tcctcttcca
    29341 gtaaaatatc aaccagggct tgattggcct tgccttcaaa gagagctgct ttgaacgcac
    29401 ggaaatcttt accgtaagct ttaaattcat cttcaccata gtgattatca attaaaagca
    29461 gttcctgacc gaggtcaagc tctttgatgg ttgaggttcc aaagacttta cgctcctgcc
    29521 agttttgtgg gcaggtgtta tcctgccaga tcatttcagg aaggctaaaa tcattagcta
    29581 ggcctaagag tttttgacat aaaagggcat tcatgctttc gcgaaaatca atggattgcc
    29641 gattatgcat gtaaacatgc tcaccttgat gtaaaaagag gtgcttgttg attgtggaag
    29701 gaagcgcatt gaaaatctca tagacctgtc ttggtttgac attccagtct tgtaagccat
    29761 gagtataaac gacatcacac tttatttgat gagcattttt taagtaattg cggtcgtgcc
    29821 aaaattgatt ataatcacca gattgtcggt ctaacgcctg agactgttgg tttagcaatt
    29881 cttgataacg atcattatgg cgaagataat cgccagccaa taaattacgc gagtaggtga
    29941 gctcagttag gacatctaga tcctctccag gatagccacc aggactacaa actaagccat
    30001 tttcgcggta gtagttatac caagaagaaa tagctgattc tgcaataatc atggctaatc
    30061 cgtctacgcc tgtagtggct aaaccagtag acatagttcc caagtaggac tttccagtcg
    30121 tacaaactag accatttgcc caatcagctc tcacttggtg ggtttttgag tggctggtgt
    30181 aggctgtggc tcttccattt agccaatcaa taacggcttt aaagctttca atttgagcat
    30241 agtctccact cgtcataaag ccagtggaac cagcagttcc cacacctgaa acatagatat
    30301 tagcaaaccc acgtgcgagg aaataatcgt tgaggctata ggagttaatg tagctaaagc
    30361 tttctagatt ttgacctata ggaagtttgc aaggctgtgt ctcaagagga ataaaatccc
    30421 tgtcttcgac agtgatttgt ctcctttttt taacgactaa ctctttttcc atacgataaa
    30481 gttttttgtc gttggctact tcattgatac cttgatggta tggactaggt gtcatcaaag
    30541 ttggtaatgg tttttgagat tgaggacgaa tgatattaac cttaataaga tcaagttggc
    30601 catcttgatc ggtatcaaga ggtgcttcaa cgtaaacaac ttctcgaatc agctgtgacg
    30661 tgtcaaaggt agctaatgat ttaccgttga agaagtggta atcattgtcc atagtaagca
    30721 ttccttggct gaccaaatca tcaatcaggg tcatgccaga cttacaacgg gtcgctaata
    30781 agtggtggat atgcttgata atttctgttt cgtcaaagtg gataggaaag gccagtttat
    30841 caaggaaagc atcggcctct gtaaaatcaa ctccaggaat aaagccaagg acttgcaggg
    30901 ccagtaaatc aaaaacctct ttggataact cttgctctga ttgaaaaaag ctcaatgcgt
    30961 ccatgtcatt tttggcgatt agatgactta aaggataatc actatcaggg tagtggaaga
    31021 agagtttacg taaaaagctt tctaggttag ctttggcagt tttttgcaga tccagatcaa
    31081 agcccaattc ttttaattct tcagccgctc tttctagact agttggaata taggaaaatt
    31141 gattatagcg cataggagtt tcctttctag tggcttagaa aacgatatta tcttttaatt
    31201 tatcaagatt ggtaatgata atatgttgtt tatcaatgcg aatgatgttt ttttctttca
    31261 actgttttag aatacggctg acgctgctag cggtagaaat gccacagaat ttaccgagtt
    31321 cctcattagt aatgacaaaa ttaattaaaa tttgaccatt tggtagttct tcgccaaata
    31381 gggtcattaa gtcatatatt tgagtagaaa tggcaccgat acggccgtta gttaacatac
    31441 attgcatttt tttcatggat ttttgaagac gattatggta aaagtccttc acatatcctt
    31501 gtagttcaat atcttcgttt atatctttta aaaatgctga gcggcgaacc ttgtaaaaac
    31561 tagctttctc tgactcgatg cgaacattat aaggctctcc catatctttt gaataaccag
    31621 tgttgagaac agaagtaatt tcaagtcctg taacatatct caaattaaat tccattccat
    31681 attttgaaag aacactctgt ttcacaatgc cgtcttttaa aatataagtg aagtcctctt
    31741 cgagactttc aaaagtcaag tacttgtgat aacttttttc aatgatagga aagttatgat
    31801 tatcaatata ccgttgcaaa atgtgatgat tcacgctttt ctccaaatat tcttttacca
    31861 atgtataatt tgtatcttca agagaaatta acatttgcta atgccctttg atagtaacac
    31921 ttatattata ccattgaaat atattatatt ctgctttttt tgtaaaatgt ttatgaaaat
    31981 agagaggagt tcattttcaa tggaagaaaa attgtttaac aaacattttg tggccatcac
    32041 agtaataaac tttatagtct atatggtcta ctatcttttt acggttatta ttgcctttgt
    32101 ggcgactaga gagctaggag ctcagactag ccaggcagga ttggcaacag ggatttatat
    32161 tctagggact ttattagccc gtttgatttt tggaaagcag ttggaggtgt ttggtcgtcg
    32221 tttggtttta agaggaggtg ctatttttta cctcttaacg accttagcct acttttatat
    32281 gccaacgatt agcatgatgt acttggttcg tttcttaaac ggatttggtt atggtgtggt
    32341 atcaactgcg acaaatacca ttgtaacagc ctatattcca gcttgtaaaa gaggagaagg
    32401 aattaatttt tatggcttgt caaccagtct agcagcagct attggtcctt ttgtaggaac
    32461 ctttatgttg gataatcttc atattgattt tcgcatgatt attgtattat gtagcgtctt
    32521 gattgggtgt gtggttgttg gtgcttttgc ttttccagtc aaaaacatgt ctttaaatgc
    32581 ggagcaattg gctaaaacca aatcgtggac tgtggatagt ttcattgaga aaaaagcctt
    32641 gtttatcact gcaatcgcct ttttaatggg gattgcctat gcttcagttt taggatttca
    32701 aaaattatac acgtctgaaa ttcatttgac agcagtaggt gcttatttct ttgtggtcta
    32761 tgccttaatc attaccatca ctcgtccagc aatgggacgt ttaatggatg ctaaaggcga
    32821 taaatgggtc ttgtacccaa gttatctttt tttagcaatg ggactcttct tgctaggtag
    32881 tgtatcgtct ggaggaagct atttgctttc aggagccttg attggctttg gttatggcac
    32941 ttttatgtct tgtggtcaag ccgcctccat acaaggagtg gatgagcatc gctttaatac
    33001 ggctatgtct acttatatga ttggtcttga tttaggttta ggtgctgggc cttacctctt
    33061 gggcttgatt aaagatttgg cacttggtag tggtgtggct tcctttaggc acttattctg
    33121 gttagctgct gtgattccac tgatttgtac cttgctttac ttgttaaaaa caaagacaag
    33181 acaggttgtg tcttaaggac aagaaaagga gtttagtctt atacttaaat acaaacgtat
    33241 cttaacagct gtagatagtt cctatgagcc gggattagct gtgggtaaag ccattactgt
    33301 agcgctttga aataatccta gtttgctatt ggtacatgtc aataaaaatg actcgcaaaa
    33361 gccattcgtg aaagagaaaa tgtggcctta tttttagtag gtgcaattgg attaacatca
    33421 gaatatagga tttgtcatgt taagattgat ctgttgatag tgagagctaa taaaaaatgt
    33481 tataatacta tgaaataaag tgataaagat aaggtctttt atggtccttt tctttaccgc
    33541 ttttattatt gtgtgaaaat aacacttaat gatcatttta tttattattt tattaccttt
    33601 acattcatca ataagcctgt taaaatggta tttgttatat tttattattt ggaggaaacc
    33661 agaaaacatg gaaatgacat ggactgtgaa atacatcaca gaatttatcg caacggcttt
    33721 tttgattatt ttggggaatg gagctgttgc taacgtcgac ttaaaaggaa caaaaggaca
    33781 taactcaggt tggttagtga ttgcttttgg ctatggctta ggagttatga tgccagcttt
    33841 gatgtttggt aatgtatctg gaaaccatat taatcctgct ttcacagttg gactagcagt
    33901 atcaggcttg ttcccatggg ctcacgtctt acaatacgtt gtggcacaat tacttggagc
    33961 tatctttggt cagttggtag tggtaatggt ttataaacct tactttatga aaactgaaaa
    34021 tccaaatcat gttttaggct cattctcaac gatttcatct cttgataatg gtcaaaaaga
    34081 cagccataaa gtctcttata tcaatggttt cttaaacgaa tttgtaggtt catttgttct
    34141 tttctttggt gctttggctt tgactaaaaa ctactttggg gtagagttag ttggtaaatt
    34201 gattgaagca ggttacgacc aaacaactgc agcaacacaa atttcaccat acgtgacagg
    34261 ctcattggcg gttgctcaca ttggtattgg tttcttagtt atggtcttgg ttacttcatt
    34321 aggtggacca actgggccag cactaaaccc agcgcgtgat tttgggcctc gtttgttaca
    34381 ccacttctta ccaaaatcag ttcttggtca agccaaaggt gattcaaaat ggtggtatgc
    34441 atgggttcct gtagttgcac ctatcttagc ggcgatagta gccgtagcag cgtttaaata
    34501 cctttatatc agataaaaaa agaactaaag cttcttttag actcaagaca agctcgctta
    34561 aggaacttgt cttttttata tgagttaagc gaaatctaat gcaaacttga ctgtcttgta
    34621 tagcgtattt tgtaaatttt actagacttc ttgtaaaaaa gcctctcctc agataagatg
    34681 actaatgcct ctaaacggtg ttacaaataa acgaggcatc cctaacttcc tttatctggt
    34741 gttgaaacta ttttgcacgg actaaatcac tgatagagta aaaaacgatt tttcattttt
    34801 gttgtaaaat attaaaaacg tctctggtta gtgattccca gaaacgttat cttatctatt
    34861 tgtttgttgc ttatgagagg taaaggagga acgaatcagc attccaccag tgaagaaaac
    34921 gatagcgatg accagaagtt tcaagctatt aatatctaaa ttcgttaaga aaaacacagc
    34981 tagtaaaacg ccaataatac caccagaaac aattccagca aaaccatccc aactgacacg
    35041 gtttgctttg ataaactggc tactagaagc tgtcataatc atagctgcat ctagcatcat
    35101 aacaggcata gcaactgttg ggctaagacc cattaatgaa aagaaaatca attctggagc
    35161 ataattgcct aaccccatag tcatcaagac tccaacgata aaattaaaac caattccaac
    35221 aaaaagccag atgccatgga ggccatgaat ggtgtctgaa aggtgttctc ctggatggta
    35281 gattattcta atgatcatga ttatagctgc tatgattaaa agactaccaa ggattcgttg
    35341 gacagttgga gcatgccagt tttttgtaat atgagtcccc aaataagctc caataaaagc
    35401 tgctgcagcc atagcaagta aagttagaac ctcaactttt acgacaaaaa taaagcaaag
    35461 agattgaatg agcaccggaa gcacatgagc tacggtcata gtgccaggca attgtctatc
    35521 gtcagtgact aatttagtta acttaaagca cgttgtggta gtagcaaaag accctatccc
    35581 aagggtgtca agggcatctg ttagcaggcc aatccaaaac cccgtccaaa agcgtttaaa
    35641 aggattgatc ttattttttt taagatgttt tactaacata aagaaaataa aaagcattgc
    35701 cgaaactagc aaagcttgta tcagtctaag gataagcatt tcgttcataa agactagttt
    35761 acaaaaaaaa accttagccg tcaacgtgat ttacttcatt aaaacatgcc actatgcttg
    35821 gaagagcttt ggttcgatgt attttgttaa aattaagcta aaatattaat attgcatgaa
    35881 aggggacgcc ttcctttttc ccttactgag cttagctgtt attgtagtga atgtttaaaa
    35941 ggctagtttg tcgatcttta tcaaaaatct agtaggatga atacgtataa tttcttgtca
    36001 aatagaggaa ttttgtctat aatagcagag gattaggagg aaattatgac tttaatggaa
    36061 aatattacct ttaaaactcc agtattacgc gttaatgatc gcgaccttaa tattgcattt
    36121 tatcaaaata atttagggct tcgtttagta tctgaagaaa atgcgattgc tatcttttca
    36181 tcttggggag aagggcagga atgttttgta attgaagagt caccttcagt tagaacgcgt
    36241 gcggtagaag gccctaaaaa ggttaatacg attgtcatca aaacaaatca acctaaagaa
    36301 atcgaacaat tattagctca tggagcatat tatgatactc tttttaaagg tcaaaatggc
    36361 tatgcctttg agactatttc cccagaagga gaccgattct tgttgcatgc tgaacaagat
    36421 attaaacatc tccaaggtac tgatttacca tcgcttgaaa aagatgcaac ttttaaaggt
    36481 ttaactcaat ttaagtttga tattattgtt ttaaatgtta ttagtgaaga acgctcaaaa
    36541 gctttttatc gggatctgtt tagtgatcag ttacctatta ctatggattt tattcaagaa
    36601 gaaggtcccg atttggcaat tgatccccat attgcttggg atttagaaat tttagaattt
    36661 caagtctcaa aggactatga tatgaaggtc ctaaaagcaa ctttagaaga agacgggcac
    36721 aaggtctaca ttgataaaaa acacaaagta ttggtccttt ctgatccaag tcagatcgaa
    36781 gtatggttta cgaaatgact ttggcagtca ttaaatgtat tgaaaaccat cttcacaaaa
    36841 aagtatacaa aggggccagt ctggctctct ttcaatctgg tcgatggcaa gaataccata
    36901 tcggaacaat tgatggaaga cgaccagttg atgctaactt agtttatgac ttggctagtg
    36961 tttcaaaagt tgttggtgtg gccacaatat gcaatatttt attgaataat ggtacgttag
    37021 cattagatga tcccttaaaa gcatattatc ctagtattgc tgatgcgact gtcactattc
    37081 gacagttatt gactcatacc agtggtcttg atccttatat tcctaacaga gatgttttaa
    37141 atgcacaaca attaagaaaa gcacttaatc atcttactca aaaagaaaat aaaaactttt
    37201 attacacaga tgtcaatttc ctcttgttag gctttatgtt agaagagctc tttagtgaat
    37261 ctttagacca gatatttgat aagactatct ttactccttt tgggatgtat catacgtctt
    37321 ttggccctcg tccagaagct gtaccaacat taaagggtgt gagtgatgga gaagttcatg
    37381 atcccaaagc aaaaatctta aaaaaacatt ctggatctgc ggggctattt tcaactcttg
    37441 cagatttaga aagttttagc aatcattatc ttaatgatcc attttcagat tgtctgtggc
    37501 gcaactacag ccaacaaaca attgagcggt cactagggtg gaatttagat ggcgattgga
    37561 ttagtcatac aggttacaca gggccatttc taatgcttaa taaaaaagag caaacggcag
    37621 ctattttttt gaccaaccgt acttacgacg aggatgataa aagtaaatgg ttaaaagaac
    37681 gtcagttgct ttacaatgca ctaaagcatg atctgacaac ccccgtatcg taacgtctaa
    37741 aggggcagtt ttagtgatct tattactgtt tttaaagttt cttctaaaaa atagccattt
    37801 catttgtctg atgcgattag agtgattata agtgaaaaaa gaatagccat ctcattttga
    37861 atcaaatgag atggctgttc ttttttataa gttattgatc atttagatac tactatttac
    37921 ttgaaatagc ttcagcagca tcgtccatgg aaagcacttc gtggaagaca cgttgtgtca
    37981 actcagtttt ttgttctggt gtaaggtatt tggtgttgac acagtaacca gagatacgta
    38041 cgataacgtc ttcgccgttc atgattttgt cataaacatc gttaaggtcc ataacgttca
    38101 agttaacgtg ctgaccacca ttttcaaagt aaccgtcaag cactgttacc aagttgtcaa
    38161 cttgttcgtc aaatgtttta ccaagagcac gaggtgatac ttgagtagtc aatgagatac
    38221 catcgttagc atgtgagaat tccagtttag caagtgagtt aaggttttgt aaccagccac
    38281 cttttgcttt gttagatggg ttagcacctg gtgagaagaa ttccacttgg ctagtgttaa
    38341 ctgtaccatc ttcgttcaag aagacgccgc ggtggactgg agagttacca gtttgtttag
    38401 agtaagcaac gtttgaagtg atggtaagaa gtgatactga agcctcagca ttcttgtaaa
    38461 gtttgtggct tgcaagacgt gtgtggtaag cttccatcaa ccatttcgcg atgtcatcaa
    38521 cacggtcgtc atcttcaccg taacgaggga agtcacctgt tacttcgtag tcatagatgt
    38581 agccattttc atcgcggata gttttaacag ttgcgtattt aatagctgac aaggtatcaa
    38641 ctgtgttagc gaaaccacag ataccgaatc ccatgttagc acgttggtgt gttggcaaga
    38701 aggccatttg aactgcttcg tagttgtatt tatcagtcat gtagtggatg atgttaagcg
    38761 catctacata agtatctgtc aaccagtcaa gagatttctc aaagttagcc ataacttcgt
    38821 cgtactcaag aacttctgat gtgattggtt caacaacgtt aaacactttg tagtctctgt
    38881 gaacatcatc gtaaccaccg ttaagaccag taagaagggc tttaagaacg tttacgcgag
    38941 caccgaagta ttggatgtta tgacgttgtt cttcattttc tgggtcaagt ggtgatacac
    39001 aacatgaaat acatgacatc tcaccataac cttctttagc cattgttgtc acaccttcat
    39061 attggataga agagtgtttg tggctcattt tcatacagta gcgacggaat gtttctggca
    39121 gttggtcagt ccaaagaact gttaagtttg gttctggaga gttaccgata ttatcaagag
    39181 tgtttaagaa acggtagtcc atcttagtca cacggtgacg accgtcgtta cccataccag
    39241 ccatagaagt tgtgatgaat gttgggtcac ctgagtaaag ggcatcgtaa gctttagtac
    39301 gaccaaattt tacggtacgg agtttaagga caaaatcatc aacaaattct tggatttctg
    39361 attctgtaaa ggtaccgcga gcaaggtcac gttctgcaaa gatatcaaga acgattggca
    39421 cacgtccaag agaagtagca gcaccgttga tcacacgaca tacagccatg aaagcgatgt
    39481 ttacccattg gatagcttct ttaacgtttt gtgctgggcg acgaacatca actccgtaaa
    39541 ggtcaccaag tttaaccact tcaccaagag cttggtattg aaggttaact tcttcgcgaa
    39601 gacgaatgga ttcttcatcg atttcagtga tagcattcca gtcattgact ttttcttgca
    39661 tcaagtagtc agcaccgtaa agagcaagac gagcgtaaac accgatgata cgtccacgtg
    39721 agtaagcatc tggaagacca gttacagtgt gggcatgacg agcgcgacga atatttgaag
    39781 tataagcgcg gaagataccg tcgttaacag ttgtcacata cttagtaaag atttcatgta
    39841 ctgctgggtc tggttcatag ccgttttctt taagggtcgt ttccgccata cggataccac
    39901 cttttggcat gaagttcaat ttgaacaatt catcgttttg aataccataa attaattcat
    39961 tttctttatc gatgaaacca gcaggaatgt cagcaattga agttggacga gtatcgtatg
    40021 ggaaacgtgt agcttcatag tgtgcttttg tttcttcgat aacttttttg atgtgaagtg
    40081 agcgttcagt agcaccagcc aagaaagatt catcgccatc gtatggggtg tagttagctt
    40141 gtacaaaacg tgagacactt gctttttctt tccagtcagt tcctttaaag ccttcccaag
    40201 ctttttcgaa aacatctgta ttggttttaa cagttgccat aaatttctcc ttaaattcta
    40261 gtaacaaagc gatctgttac atttacaatt ctaagtttaa cacataggaa acgttttccc
    40321 aagcaaaatt cttgacaaaa ttaagattct tttataatac agattgttga aacagtcaca
    40381 aactgtatta gaatgtattt ttttggcttt agatagccta aaaggtataa tagagaaagg
    40441 agggacttat gcttattttt ccactgatta atgacacgtc acgaaaaatc atccatattg
    40501 acatggatgc cttttttgct gcagttgagg aaagggataa ccctgcttta aaaggaaagc
    40561 ctgttgtgat tgggaaagat ccaagagaaa caggtggtcg cggagttgtt tccacttgta
    40621 attacgaagc gagaaaatat ggcattcatt cggccatgag ctctaaggaa gcttatgagc
    40681 gttgtcccaa agccattttt atttcaggaa attatgaaaa gtatcgaaca gttggagacc
    40741 agatccgccg tatttttaag cgttatactg atgtggtaga gcccatgtcc attgatgagg
    40801 cctatctaga tgtcaccaac aataagttgg gtataaaatc agccgtcaaa atagccaagc
    40861 tgattcagca tgatatctgg aaagaagtag gattgacctg ttcagcaggt gtgtcttata
    40921 acaaattttt ggctaaattg gctagtgatt ttgaaaaacc ccatggcctc accctagtct
    40981 tgaaagaaga tgccctgtgc tttttagcca aactccccat tgaaaagttt catggtgttg
    41041 gtaaaaaatc agttgaaaaa ctgcatgaca tggggattta tacaggacag gatttgttgg
    41101 cagttcctga aatgaccttg attgatcatt ttggtcggtt tggttttgac ctttaccgta
    41161 aagcgagagg catcagcaat tctcctgtca agtctgatcg gatacgcaag tcaattggca
    41221 gtgagagaac ctacgctaaa ctgctttatc aagaaacaga catcaaggca gagatcagta
    41281 aaaatgctaa gcgcgtggcc gctctcttac aagaccataa aaagttaggc aagaccattg
    41341 tgctcaaagt gcgttatgct gattttacca ccttgacaaa acgtgtcacc ttgccagaat
    41401 taaccagaaa tgccgcacaa attgagcaag tagctgggga tatttttgac agcttaagcg
    41461 aaaatcctgc tggtatccgc ctgttagggg taaccatgac caatttggag gataaggtag
    41521 ctgatatttc cttggaccta taggagaaag agtgctctat ccgtccgcct cattttggag
    41581 aaaaaagaag ctgattaggg atttccctaa tcagcttctt tggtccatta ttttattaca
    41641 gcatagcttg gtctgtatca tcaccttttt cgttaaggtt ttttgctttg taaaaagcaa
    41701 agccataaag agcagcttgt ataaggataa ggatagttcc aaccattgac aaggttgttg
    41761 tgaactggtt aaccaagccg ataacagaaa ggataagtcc taatatgtaa ggaatataac
    41821 taaccgttaa tccttgtttt agtttggata agttctgagt acagaagatg ataattgcaa
    41881 taatagcaag gacatttaag acagataaga aaatcataaa tggtgtcatg ctgctttgta
    41941 gctgtgccaa ttgctcagtt gttaattggg cccgaaatgc ttcattcttg agttggcttt
    42001 gtaagtagaa aatccctgca aatcccatta atgacagtac aactccaagc ccgtttagaa
    42061 taataatggc aatagtagac gttttgagtg cctgacgcac tttttcataa gaaatcatat
    42121 aatcctccta gagtccttaa tccgaaattg tataatgtgt ttaatacaaa aatattatac
    42181 catagattaa tcaaaaatgt ccgtttttct aggatttttt ctggaaaaag agggcaatat
    42241 ctgactctgt aagccctatc atcgaatcga tagtcgaata attctcaggt gttaacctaa
    42301 aatcatcatt atctgactga gagttctcag tggggttaga gtttgttgat tgagaggaag
    42361 atttttgaga gtcgtcctca agggttgccg tattagaaaa aagggaggtc tgctcttttg
    42421 attttagctc ttggttaggt tgagaggagg ctaagtcgga ttgttcttgg aagcgttcga
    42481 tcaagtaggt ttggcgttta tcgccttcgt gtttaatagc atactcaaag gcagtatatt
    42541 ctcccaacag aattaactta cttttagacc gagtaatggc cgtgtaaatc acatttcgtt
    42601 gcaagagtcg gccgctttgg cgtgtgatag gtaaaatcac cacttgaaac tcactccctt
    42661 gcgatttatg aatgctcatg gcataggcca gggttaattt tagccattca tttctagggt
    42721 acgtgacttc gctaccgtca aaatctaaga ttaattcgtc ttgcttagat tcggtgtatt
    42781 tagcaggaat caaatctgta atataaccaa tatccccgtt aaagacattc aactgagcat
    42841 cgttgactaa gtgcaggact ttatcacctt tacgaaaatg cgtatcattg aacagaaatt
    42901 ctgtttgtcc ttgcaaggga ttgagaagtt cttgcatgag ttgattaaga tgattgatgc
    42961 cagcttgtcc tttgtacata ggtgctaaaa tttgaatttc ctcagcaggg atgccacttt
    43021 taatagcaga taggacaatt ttttgaatca tgtcagggat aaaggctgct tgggcttcaa
    43081 aataagaacg gtcagctttt ttatcacgaa agtcagcagc taagattcct cgacgcatct
    43141 ggtctgccaa attgacaata gtagattctt gggattgacg aaatatcttt tgcaaggcga
    43201 tttggggcag gctattgact tttaaaagat ctgacaggac ttgaccgggt ccaaccgaag
    43261 gaagctggtc actatctccg acaataatca cttgagttgt tgagttaatc gctcctaaca
    43321 actggttggc aagccaggta tccaccattg aaaattcatc gacaatcagc aagtcgcagt
    43381 ctagataatc ctccatggct tggtaatcgt tgtcgccatt gaggcctaag tgcctgtgga
    43441 tggttgcgct aggaagtcca gtcaactcat tcatgcgacg tgcagctcga cctgttggag
    43501 ctgctaacaa gataggaagg tcttttttat ccaaatcaat ctgatgcagg ttcgcgtaag
    43561 cctgcaaaat acctcgaata acagttgttt ttcctgttcc gggaccacct gttaggagaa
    43621 agaccttgct ggttaaggcc ttagtaatgg cttcttgctg cacttggtca taggtgatgg
    43681 caaagtcttt ttgaacggct tggatggttg tttgaatggt atcatgacta aatgactgac
    43741 ttaaaggagt atctaagaga cgagagatgt tgttagcaat cccttcttca gcaaaataaa
    43801 ggctagcatc aaacagtttg gtgtcactgt ttttgatttt gccctctatg atcaactcgc
    43861 ttagttgttc agccacagca gcaggatcac attctacttg acgtgcatct tcaaggagtg
    43921 tgatggcaaa gtctaataat tgtcgtgctt ggacataagt atctcctcga ttgatggatt
    43981 cttccaagag acagtgaagg agggctgcac gaaaacgttt cggagagtcg ctttcaatcc
    44041 ctaagttttc agcgagagca tctgccattt taaacccaaa accttgtaga tcttcgacta
    44101 actgataggg attttcttta acaaggtcaa gagcctcttc tttatacttt tcaaacgctt
    44161 gaagggcaaa acggttgcta aggccaagtt cgacgagacc agcaatcagt tgctctgtgc
    44221 cgtaattcaa ttttagttta gcgacaaagg cttgacgatt agccttagat aggccagaga
    44281 tagtttctaa tttgcttggg tcttctaaaa tatggtcaat ggtattatga ccatatagcg
    44341 caatgatttt ctccgctgtt tttttaccaa tccccttaaa atggtcgcta gagaaataat
    44401 taaccaaacc agatgaacta ggtttgattt tttggtaacg gcttagtttg agttgctgtc
    44461 catatttagg gtgctgggtc aattcccccc aaaaggtgta gtcatctcct tcaataatat
    44521 cagccatcgt ccctgtgata atgatttcaa agtcgtcaat atcactatct gtgtcttcga
    44581 tggcaaggag gagaatttta aaaaaattag ctgcattttc aaagataatg cggtcaacag
    44641 taccagtaaa aaagtgttcc ataaggcacc tttctgtcta tacaagatag tcgaaaacct
    44701 gcccaaaggc aggttttttc taattaaaga cggtcatttt attgagtggc caaaaacgag
    44761 ctttcacttc accgataagg ttttcttttt tgaaactacc aacttcgcga ctatccctgg
    44821 aaacaatacg atcatcacca agaagaaggt attctccttt tggaacactc atctcaaagc
    44881 gtgtttgtcc ctcagaatta gttgtaaaag catcagatgt ttctgctaac tgttggaata
    44941 gggtattata ggcgtaagtt ttttggagtt tatcgttttt aaattgtttt agatactcag
    45001 ccaaatacgg ctcaactgtt tttttaccat taatataaag tgtgtcatca ttataagaaa
    45061 tggtatcgcc tggcaatcca acaactcttt ttacgatttc tttcttttgt ccgttttctt
    45121 cttcctgagc aactacaata tcaaagcgat caatcctagc ttgattaaaa acgataaggc
    45181 gttcgccatg agctagagtt gggtccatag aatggccgtc tactttaaca gcctgccaca
    45241 aaaaaagacg agatagacca aagagaatta aaaagagagt gaatgggccc cattctttaa
    45301 taaactgttt catatgattc cttttattta gtgagaagcg cttgcgcttt gtgagtgttg
    45361 gcgaagtgaa gtttagcact atattctaag ctagacatac cataagcggc taagagttgg
    45421 ctagcaactt tatctgaagc tgaaccagca ccgcttggga gttggtaacc taaatcttga
    45481 cctaattgat cgagattgtc taaaaataga tttctagcaa tgatagagct aacagccaca
    45541 gccaaatagt gactttctgc cttttcttga aaggttagag gatttgggaa atggcttttt
    45601 tcctttttta gatgcttttc ataatttgat tggctagtga aagcatcaat aacaatttgt
    45661 ttaggttgaa tgcctttttg taacaacaaa aaaatagctt ggttatgaag agcaactttg
    45721 atagaaatgg cattatatgg tttactttta ccaaccaatt cgttatattt tttaggtgat
    45781 aggagaagtg attgatgagg tatttgtttc tctaacagag gcgcaatctg ttgaatggtt
    45841 ttatccgata attttttaga atcatcaacc ccaagctttt tcaggaagga atgatcttta
    45901 ggatcgacaa aacttgccac aacagcaatc ccaccaaaat aagagccatt acccacctca
    45961 tcactgccga ttataggtat atcttggcta ttgttgcttg cttcaaaaac tgtcttagct
    46021 actggaagat taagctcttg agctaaagca tttgcaccgt ttccctggag aactaatttt
    46081 ccggatttgt acagcaaaac agtaacccca ttttttttag cagcaaaggc tacataggta
    46141 ttttggctat tgatggtgta gggggctagc tgttttttta aatgtttact cagtatagca
    46201 tctattttca aaactaaggt attcataata attattttaa cataaaatag ttgactatgg
    46261 ttaattcata agtttattta acaaagaaaa cagagactcg aatttttaga caggttaggg
    46321 caatggtgtt gactatttta cgaaagtttc attttacggt ataatgctag tgaggtgacc
    46381 ctatgaaaag tattaatcgc tacaaattca cctttggtga aaaaacatta acattgacaa
    46441 ctgacaaaga caatctcttt atggaagaag ttgagcgggt agctaaagaa aagtatcagg
    46501 ctcttaaaaa tcatttacca gaagctgatg acgagacaat cgctatttta atggctatca
    46561 ataccttgtc aacacaatta agcagagaga ttgccattga aaaaatggaa gctgaaattt
    46621 tagatttacg tcaaaaaacc ttggttggtc ttcaagaaaa agctaatcaa atagatgtga
    46681 atgaggttta atcatgttat ctttattgat agtgcttgtt ttaacttgga atttttatat
    46741 tggttatagt agaggtatta ttcttcaatc gttttatgtc ttaggagccc tactttctct
    46801 tttggtagct aatcgatttt atattggatt agcccataag ctaacgcttt ggattcctta
    46861 ttctaacccg gtagaaggaa catcagtctt tttctttaaa tcagttgata tctttgtttt
    46921 agataaggtt tattatgcag gccttgcctt ttttatcatt ttcttattgg ggtatgcact
    46981 gagtcgcttt cttgggattt ttgttcattt ccttttgcta gattattttg ataaccagtg
    47041 gacaaaatgt ttgagtggcg gactagcgct tctagtatcg cttctttttt tgaacatgtt
    47101 actgtctatt tttgcaacgg tccctatgcc ttttttacag cactatttgc actctagttt
    47161 tcttgctcgt ttggtgattg aacaccttcc accattgaca ataattattc aaaaattgtg
    47221 gattcaagcc attatttgat atcgttttgt gactaatata agaacctgga gtgagtttca
    47281 cctttaggtt ctttatttac gagaaactgt ttagaaataa agagaacgca tgggaactta
    47341 gtgactttct tgccacattt tccatcattt taggtataat gaagagtatg aataacaaga
    47401 ttttagagca gttagaattt aacaaagtta aggaattgct attaccttat ctcaagacag
    47461 aacaatcaca agaagaatta ttagagctgg agccgatgac ggaggctcct aaaatagaaa
    47521 aaagttttaa tgaaatttct gacatggaac agatttttgt tgaacatcac tcatttggca
    47581 tagtcagcct aagttcaatc tctgagagtt taaaacgctt agagctttca gctgatctta
    47641 atattcaaga acttttggct atcaaaaaag ttttacagag ttcttcggat atgattcact
    47701 tttattctga tttggataat gtttctttcc aatctttgga tcgtttgttt gaaaatttgg
    47761 aacaattccc taatctgcaa gggtcttttc aagctatcaa tgatggtggt tttttagaac
    47821 attttgcgag tccaaaatta gagcgtatcc gtcgtcaatt aacaaatagt gaacgacggg
    47881 ttcgtcagat tttacaggat atgcttaagg aaaaagcaga gcttttatca gagaatctaa
    47941 tcgctagtcg tagtggacga agtgtcctac cagtaaaaaa tacttatcgg aatcgtattt
    48001 ctggtgtggt tcatgacatc tcttcttcag gaagtactgt ttatattgag cctcgtgctg
    48061 tagttacact aaacgaagag ataacgcagc ttagagctga cgaacgccac gaagaaggtc
    48121 gtattttaca cacattttca gacttgttaa gacctcatgt cgccactatt agaaataatg
    48181 catggattct tgggcatctt gattttgtaa gggctaaata tctttttatg tctgataata
    48241 aggcaacgat acctaagatc tctgatgaca gcacgttagc attaatcaat gttcgtcatc
    48301 ctcttttaag taatcctgtg gctaatgact tacattttga tcacgattta actgcaattg
    48361 tcatcactgg tcccaatact ggtggtaaga cgattatgct aaaaacactc ggtttagcac
    48421 aattaatggg acagtctggt ttgccagtat tagcggataa aggtagtaaa attgcagtat
    48481 ttaacaatat ctttgcagat attggcgatg agcaatctat tgaacaaagt ctatcaactt
    48541 tttctagtca tatgacgcac atagtcagta ttttaaacga ggctgaccgc aatagtttag
    48601 ttctctttga tgaactagga gcaggaacgg atcctcaaga aggtgctagt ttggctatgg
    48661 ctattttaga acaccttagg ttaagtcata tcaaaacgat ggcgaccacg cactatccag
    48721 aattaaaagc ttatgggatt gaaacaaatt ttgtagagaa tgcgagcatg gaatttgatg
    48781 cagaaacgct tagtcctacg tatcgcttta tgcaaggagt tcctggacgc tcaaatgcat
    48841 ttgaaattgc ttctcgcctt ggtttagctc catttattgt taaacaagct aagcagatga
    48901 cagattctga ctcagatgtt aaccgtatta ttgaacagtt agaggcacag acacttgaga
    48961 cacgtagaag actggatcat attaaagaag ttgaacaaga aaatctcaaa ttcaatcgtg
    49021 cggttaagaa actctataat gaattttcac atgaacgcga taaagagtta gaaaaaatct
    49081 atcaagaagc tcaagaaatt gtagatatgg ctttgaatga gagtgatact atcttaaaaa
    49141 aactcaatga taagagccaa ttaaaacctc acgaaattat agatgctaag gcacaaataa
    49201 aaaaattagc acctcaagtt gatttatcaa aaaataaagt cttaaataag gctaaaaaaa
    49261 tcaaagcagc tcgtgcccct agaattggtg atgatattat agtgactagt tatggacagc
    49321 gaggtacctt aactagtcaa ttaaaagatg gccgttggga agcacaagtg ggaattatca
    49381 aaatgacatt aacacaagat gaatttagcc tcgttagagt tcaagaagaa cagaaagtca
    49441 aaaataaaca gattaatgtg gttaaaaagg ctgatagttc tggaccaaga gctcgacttg
    49501 atcttagagg taaaagatac gaagcagcaa tgcaagagtt agatcatttt attgatcaag
    49561 cattgcttaa caatatggga caagttgata tcattcatgg tattggtaca ggcgttattc
    49621 gtgagggagt gacaaaatat cttcgtcgta ataagcatgt taagcatttt gcttatgccc
    49681 cacaaaatgc agggggatct ggtgccacaa ttgtaacgtt agggtaaatg atggaatcat
    49741 atgaacactt ttatgccaaa ctatctcaac cttttagaaa aaccccacag ttaataattc
    49801 ttttaaatgt tttactaaaa ataatcacag gagtgatgta catactttat ccatcttttc
    49861 tgatatttac gctttggcaa gggatgacat ttcaattatg gttaaggcta ttaattattc
    49921 ctgctgttgg ctttatagct ttgtcttaca ttagaaaacg ctttgatttt ccacgaccgt
    49981 atgaaaaatg gaatattaaa cctttaattg ataaggatac aaagggaagg tcaatgccta
    50041 gcagacatgt tttttcagct acgatgatta gtatgtgttt gttacgatat tatgtttact
    50101 ttggaatagt ttgtttaata ttatcggttt tattggcaat ttgccgtgtg atagcaggta
    50161 ttcactatcc taaggatgtt attgtaggtt accttattgg cttgatgtta gggctttgtt
    50221 tattgattta gcgagttcgt agcaaatagt ttcaaaaaca actaaattct tgtacaatag
    50281 gcttatcatt aagatgaaat ggagaaaaaa gatggcatta gaagtaacag atgctacatt
    50341 tgtagaagaa actaaagaag gtttagtact cattgatttt tgggcaactt ggtgtggtcc
    50401 atgtcgtatg caagcaccaa tcttagaaca gttatctcaa gaaatcgatg aagatgaact
    50461 caaaattttg aaaatggatg ttgatgaaaa tccggaaact gctcgtcagt ttggtattat
    50521 gtcaattcca acattgatgt taaaaaaaga cggagaagtg gttaaacaag ttgcaggtgt
    50581 tcatactaaa gaccaactga aagctattat tgctgaattg agttaactaa aataaagccc
    50641 agcgtcacgc tgagctttat tttatgacct actaacttca atggaataac catgtgaaca
    50701 taaaacgact tgcaaaaaca ataacaacag taatgaggaa aaatacagtg acaataaggg
    50761 gtttctgata aggaagtttt gctctttctt ctcgtttttc gatttcgtct aataattttc
    50821 catttgaaac agctaggatt tccttataag gttgcacatc atattttttc ttaaaacgtt
    50881 ccacacgatt agcataagtc atagtaatta tcgataataa aacaaaaatg ccaagtccta
    50941 gccactctaa gaaatagact aatggataac ttgaaatcat taatagtatc atcaatgtta
    51001 ccattacttt ggtatctcgt tcaaaattct ttttatcaac ttgagtgatg gtatatttca
    51061 ttttctcaat gtctccttta atgagttggt ctaagctcac ttgaaaaatt tgacttagga
    51121 gtaagaggct atggatgtct gggtaagttt tgtcattttc ccagttagat atgctctgac
    51181 ggcttacata gactttctcg actaattctt cttgcgagag cgtttgttgt ttacggtagc
    51241 gaatcatttg ctgaccaatt tccataaata tctcctttca taaaattagt ataagaatga
    51301 taagctaacg ggtctatcaa atgtatttga cattagggat agatcactat ttataaggta
    51361 ttaaaagaca atctgaggaa aactttacag cggcgtaaag gaattgtaaa caaaaagtga
    51421 accgtcatag ttcacttgtg attaagcatt tttctgtttt aagtaggtct ctagcatttt
    51481 cttttgtggt gttgcaaagg gatacagaga aaagtcctca attgctaccc actttaggtg
    51541 aggagcatta ggtaaatctg ttgctttgac caccccctct atgagttcta ttgtccactt
    51601 ctggtgacta aaagtgtgct taatatttgg aaagtgatta tcagtccatt ggggctttaa
    51661 ttgatattct ctttcgaaag tttcattttg ggtttgccag attatggggt tggattgatt
    51721 gtcatcaaat aaatctaatt gttgagaaag aggtgacgtt tcgataatag gaaatgacca
    51781 aaaacctcct agaagtctcc ctttagtatt tttctccagt agatattggc cattttggtt
    51841 acgaatgaca aaagcctgaa ttcgcattgg tttaggcttt ttctttggat tttttatagg
    51901 gtatttacca taagtaccat tcaaataagc agcgttaaag aaacgaatag ggctttcatc
    51961 aggtctaggt gtcttagcgg attcgatgtc tgtacctaga tccataagtg cttggttaaa
    52021 atcaccgggt ctgtcagggt caattagtat ttccataata gcttgaaaaa ttttacgatt
    52081 tttagggtca ccgatatcat aattaacttc aaacaaacga gccatgacac gcatcacatt
    52141 gccatcaaca gcaggctctg gtaagttgaa tgagatgctg gcgatagcac ctgcagtata
    52201 aggaccaatc ccttttaatg aagcaatatc atcataagtg tgaggaaata tgccaccaaa
    52261 atcaaccatc acttgctgtg cagccttttg catattacgc acccgagaat aatagcctag
    52321 tccctcccat gcctttagta attgttcttc aggagcgtct gccaaatctt ttatttgagg
    52381 aaaccactct agaaaacgtt tataataagg gattaccgta ttaacttgtg tttgttgcaa
    52441 catgatttca gaaacccaaa tatagtatgg attagtagtt cttcgccaag ggagatcacg
    52501 tttttcttgg tcataccacc ctaaaagtgt gcgacgaaaa gaagcgattg tctcattatc
    52561 ccacatatta ataccataat cttttaattc aatcatgttg ttattgtaac acaggagtct
    52621 taaaaagagt aaaaaaagat tttaggtatt tgcgaaaaag aaaaggaaat attataataa
    52681 tattaggttt acctcatcta aatgttgatt tagaataact gaaattaacg atagaagcag
    52741 acaggtttta atttggaggg gacatgttcc agaaattaaa gaatcttatt gatcggtatt
    52801 cgtggttcgt ttttataatg atgattcttg tgttatttct taactatatt tatccatttg
    52861 atccttcttt gagcggacta cagttggaat ggctgatcat gacgcaagtt tttcctggat
    52921 taggtatcgt atgtgccatg gttgctatta tttttaaaaa gtttaacctt tttgttttgg
    52981 ccctaatttt atattttgca ctttggttaa aacttttcct tgctttttct tttttcacct
    53041 attttttagg agtctgacta agtgccaatt tttaaaactc gtgaaaggaa atgtttgaca
    53101 aaacttagtc aagtagaaaa agttccttgc ttttaattga ctattagtgt acaataagat
    53161 tctgtgagta tacctcactt actcactcca aaagtagtga gtcattagac caaaaggagg
    53221 aaaatatcaa tggctaaata cgaaattctt tatatcattc gtccaaacat tgaagaagaa
    53281 gctaaaaacg ctttggtagc acgctttgac tctatcttga ctgacaacgg tgcaactgtt
    53341 gttgaatcaa aagattggga aaaacgtcgt cttgcatacg aaatcaacga tttccgtgaa
    53401 gggctttacc acatcgttaa ccttgaagcg actgacgcag cagctcttaa cgagtttgac
    53461 cgtctttcaa aaatcaatgg tgacattctt cgtcacatga tcgttaaact tgacgcttaa
    53521 ttccaactaa gagggtagtt tatgattaat aatgtagtac tagttggtcg tatgaccaag
    53581 gatgcagaac ttcgttacac accaagtcag gtagctgtgg ctaccttcac acttgctgtt
    53641 aaccgtacct ttaaaagcca aaatggtgaa cgcgaggcag atttcattaa ctgtgtgatc
    53701 tggcgtcaac cggctgaaaa tttagcgaac tgggctaaaa aaggtgcctt gatcggagtt
    53761 acgggtcgta ttcagacacg taactacgaa aaccaacaag gacaacgtgt ctatgtaaca
    53821 gaagttgttg cagataattt ccaaatgttg gaaagtcgtg ctacacgtga aggtggctca
    53881 actggctcat ttaatggtgg ttttaacaat aacacttcat catcaaacag ttactcagcg
    53941 cctgcacaac aaacgcctaa ctttggaaga gatgatagcc catttgggaa ctcaaacccg
    54001 atggatatct cagatgacga tcttccattc tagtcagaat ggattgaacg aatacgaaat
    54061 tatttgagtt cgggctaaaa atttagaact tagaatttag atcaactccc taggaaatca
    54121 agatttcttg ccagttttct aaaattcagt cttttttaag agcccttaac atcataattt
    54181 ataaaggaga aaatacatgg ctcaacaacg tcgtggcgga ttcaaacgcc gtaaaaaagt
    54241 tgatttcatc gcagctaata aaattgaata tgttgattac aaagatactg agcttcttag
    54301 ccgtttcgtt tcagaacgtg ggaaaattct tcctcgtcgt gtaacaggaa cttcagctaa
    54361 aaaccaacgt aaagtaacaa cagcaatcaa acgtgctcgc gttatggctc ttatgcctta
    54421 cgtaaacgaa gactaataaa ccaacagtcc atttcggact gttttttagt tgattagaat
    54481 agtctatgca tgtagatgaa ttttgtctaa aataaagatg agagtaaacg aaaatccttg
    54541 cgtagacagc aaggatgaaa tgattgttat ttgttaacag gtgacatagt gttttgaatg
    54601 ttgtatttgc gttgtaggta atagcgtaaa gcaagggaaa caccaccgat aatgagcaag
    54661 acaagaggag gcaactgtgg attaagagag gttggtaaaa aggcagttgc agagtacaag
    54721 gcaatccaaa tcaacatagc taatgataag gctgcgatga ttttgaacca acttggacga
    54781 aggctcttat cttttccgag atgacggtaa ataaagtaat aagtagcgta catggatgct
    54841 cctccaccaa aaccaagtgc cagtaaggaa atcaatcctg taactgtagc gtttgtgttg
    54901 aagaaggtca tgatgccatt taaaagggca acaattccga tgaatagcaa agaggtatct
    54961 agccacatca accaaggatt ggtgtttttg tcagtttctg ctgctctttg actagggtct
    55021 tggctaaaag aagctgccca agcagtcgga gtgcctaata gatttcgagc ggtgacacct
    55081 tttttctggt tttctagaat agctggaatg gcttcttcga gaatcagctt aatatcctca
    55141 tcagacttgc cgtcttggat taatttgttc gtagcggtgt ggataaattc ttgatttttt
    55201 ttggtaagtt cttgtaattc catgggaatc ccttctttat atgggttagt taaagtaagt
    55261 caatggtatt agctagttgt aatgaaactt tggagctagc cgtttgacac agagttttgt
    55321 caggtcttaa ccgcattctg cagcttgctc cactctagaa ccattttttt ctaataaagt
    55381 aaatcacaac aaaggaacta agtagcatag caatcaaggt aatataccaa aaagcatgtt
    55441 ctaggccatt tagtggtaac cagttgtttt ggaaattcat accataggcg gagaaaatca
    55501 cagttggtat atctaaagcc atggtcatca aggccagtgt tttcataatg gtgttctggt
    55561 tgttgttgat aatagaagca gtggtttcag tcatggcatt caagacattt tcataaatgc
    55621 cagccatctc aatggcctgt tgggtttcaa tcaaggtatc ttctagcaaa tcctcgtcct
    55681 caatgtattt cttgagagag cttgttgagc tggataattt cttgacgatg cgttcgttga
    55741 atttcaagga agcctttaag tagacaatgg atttttcaag ttccatcatg tcgataagtt
    55801 cttcatttcg agtagctgct tcaagctgag cttccaaacg ttcgctttgg cgatcaatgg
    55861 tcctcaaggc agtcagaaag agctcggcgt tgcgatatag aatctgaaaa acaaaacgtg
    55921 tcttcatgaa ggtatagaaa tttttgaccc ggcggttatg aaaatgatcg aaaagggtca
    55981 tgtcatgcag acaagttgtg ataacagcat tttccgttac aataatgcct aaaggcatag
    56041 taatatagta acttttattg ttacgttctt cgtatatcgg gacgtctacg ataattaggg
    56101 tataatcatc ttctacggca atacgtgagg tttcttccac gtccaaaggg gcgcgcaagt
    56161 cagaaatatc aatgttaaat tgatcggcga tcttcataga ctcttcttgg gaagggttaa
    56221 ccagtttaat ccaagctcct ggctcgaatg tttctatttc tttgaattca attgccgatg
    56281 aaagaaacat ttgtttcatg acaagccctc ctttttgatg attgactggt agagattgac
    56341 atcaaacctt gataataaag ccttctcaag gattttctga aaaattctca atacttatct
    56401 attataccaa aattcgcaaa gtttggggca ataggttatc agaaattttt gttataatat
    56461 aagaaagctc gatgaggagg gtgcctttag gcacattcaa gatgcaaaat aaaataataa
    56521 ttcatggggc aagagcccac aatttaaaaa atattgacgt ggaaattcca cgagacaaat
    56581 tagttgttgt gacagggtta tcagggtcag gaaaatctag tctagccttt gatactattt
    56641 atgcggaagg gcaacgtcgt tacgtagaaa gtttatcagc ttatgctaga cagttcttgg
    56701 gtaatatgga aaaaccagat gtggattcca ttgacggtct tagccctgct atttccattg
    56761 atcaaaaaac taccagtaag aacccccgct caacggttgg tacggtgact gaaatcaatg
    56821 attatttacg tttactatat gcgcgtgtgg gcacacctta ctgtattaat gggcatgggg
    56881 ccattacagc atcttctgca gaacaaattg tagagcaggt cttagccctc cctgaacgaa
    56941 cacgcatgca gattttagcg cctattgttc gccggaaaaa aggtcaacac aaaaccattt
    57001 ttgagaaaat tcaaaaagat ggttatgtcc gtgtgcgggt tgatggggat atttttgacg
    57061 tgacagaagt gccggagctg tcaaaaagta agatgcacaa catcgaggtg gttattgatc
    57121 gtctggttaa taaggatggt attcgtagcc gtttatttga ttcggttgaa gcagctttaa
    57181 ggctgggaga tggctacctt atgattgaca ctatggatgg caatgaactg ctcttttctg
    57241 agcattattc ctgtcctgtc tgtgggttta cggttcctga attagaacca agactcttct
    57301 cttttaatgc tccgttcggc tcttgtccga cctgtgatgg gctaggcatt aagttggaag
    57361 tggatttgga cttggttgtt cctgacccaa gtaagtcttt gaaagaggga gctttggcgc
    57421 cttggaatcc tatttcctcc aattattacc caaccatgct tgagcaagct atggcaagtt
    57481 ttggggtgga tatggataca ccttttgagg ccttgactga ggaagaaagg gatttagtgc
    57541 tttatggttc aggtgataga gaatttcatt ttcactatgt gaatgatttt ggtggtgagc
    57601 gtaacattga cattcctttt gaaggtgttg tgactaatgt taatcgccgt tatcacgaaa
    57661 ctaatagtga ttatacgcgc aatgtgatgc gtggctacat gaatgaattg acttgtgcga
    57721 cttgtcatgg ttaccgtttg aatgaccaag ccttgtgtgt gcatgtgggt ggcgaagaag
    57781 gacctcatat tggtcaaatt tcagaattat cgattgccga ccacttgcag ttgttggaag
    57841 aactggaact cacagaaaat gaaagtacca ttgctaaacc gattgtcaaa gaaattcatg
    57901 accgcctgac cttcttaaat aatgtgggac tgaattatct gaccttatca cgtgctgctg
    57961 ggactttatc aggtggggaa agtcaacgaa tcaggttagc aacacaaatt ggttctaact
    58021 tatcaggggt gctctatatc ttggatgagc cttctattgg attgcaccaa agagacaacg
    58081 accgtttgat cgaaagcctg aaaaaaatgc gtgatttggg taatacgtta attgtggtag
    58141 aacacgatga agataccatg atgcaggcag actggctgat tgatgtgggg cctggggcag
    58201 gtgagttcgg tggagaaatt attgcctctg gaacgccgaa acaagtggct aagaataaaa
    58261 aatccatcac gggtcaatat ttgtctggta aaaaattcat tccagtgcca ttagagcgtc
    58321 gttctggtaa tggccgattc attgaaataa aaggagcagc gcagaataat cttcaaagcc
    58381 tcgacgtgag attcccactg ggtaaattta ttgcggtcac aggggtatca ggctcaggga
    58441 aatcaacctt ggttaatagt attttgaaaa aggctgtcgc ccaaaaatta aaccgtaatg
    58501 ctgataagcc tggtaaatat cactctattt ctggtattga acatattgaa cgcttgattg
    58561 acattgacca aagtccgatt ggaaggacgc cacggtcaaa tccagccacc tatacgggtg
    58621 tctttgatga tattcgagac ttgtttgccc aaaccaacga agctaagatt catggctaca
    58681 aaaaaggccg tttctctttt aatgtcaaag gtgggcgttg tgaggcttgt tcaggtgatg
    58741 ggattatcaa aatcgaaatg cactttttgc cagatgttta tgtgccttgt gaggtttgcc
    58801 acggcagacg gtataattct gagacgcttg aggtgcatta taaagaaaaa aatattgctg
    58861 aagtgcttga catgactgtc gatgatgcct tggtattttt ctctgctatc cctaaaattg
    58921 cccgaaaaat tcaaaccatt aaggatgttg gtttgggtta tgtgaccttg ggtcaaccag
    58981 ctactactct atctggagga gaagcgcagc ggatgaaatt agctagtgaa ttgcacaaac
    59041 gctcgacagg taagagcttg tatatcctag atgagccaac gactggttta cacacagatg
    59101 atattgcaag gctattaaaa gttttggaac gctttgtaga cgatggtaat acggttcttg
    59161 tgattgagca taatttggac gttatcaaat ctgctgacca tattattgac ttaggaccag
    59221 aaggtggtgt cggaggtggt cagattgttg ccacggggac accagaagag gtagctcaag
    59281 ttaaagaaag ctatactggt cattatttga aagtaaaact acaacaatag gattaggagt
    59341 tcgtttgagc tcctttttaa tcttttaaat gctctcaaat catggtaaac ttaaagtagt
    59401 tttttcatgc tacaatattc tcaaaagtta ccaaaggagt tcgcgatgtc aggattttta
    59461 gagcaacgat taggtcactg cctaaggcag atggcagaga aggggctaga ggctcttctg
    59521 gtcacccatt taaccaatag ttattacttg acaggttttt ctggaactgc agcaactgtt
    59581 ttgataacgg ccaaacgtca tgttttgatc acagattcac gttatacctt gcttgctaaa
    59641 gctagtgttg agggatttga tattatcgaa agccgcacgc cgcttaaggt tgtggcagaa
    59701 ttgttagagg ctgatcaaat agattgcctt ggttttgagg accaggtatc gttttctttt
    59761 tatcaggcca tgcaagcaga actgtcagga ataaccttgc ttgctcagtc aggttttgtg
    59821 gagcatttac gtcttattaa ggatacttct gaaattgata ccattgctaa agcgtgctcg
    59881 atctcagaca aagcatttga agatgctctt gattttatta aaccagggac aaccactgaa
    59941 cgtgacctgg ctaatttttt agattttcgt atgcgtcagt atggtgccag cggcacatca
    60001 tttgatatca ttgtagcttc aggctatcgc tctgccatgc ctcatggacg cgccagtgac
    60061 aaggttatcc agaataaaga gagcttgacc atggactttg ggtgttacta caatcactat
    60121 gttagtgata tgacgaggac cattcatatt ggccaagtta ctgatgaaga acgtgagatt
    60181 tatgctcttg ttcttgctgc taataaggct ttaattgcta aagctagcgc tggcatgact
    60241 tatagtgact ttgacggtat tccgcgccaa ctcatcgctg aggcgggtta tggcagtcgc
    60301 ttcacacatg gcattggtca tggtatcggg cttgacatcc atgagaatcc attttttggg
    60361 aaatctgagc aacttctcca agctggaatg gtggtaacag atgagccagg tatctatttg
    60421 gataacaaat atggtgtccg tatcgaagac gacttggtta tcacaaaaac tggttgtcaa
    60481 gtcttgacct tggcacccaa agaattaatt gtattgtaaa agaatggttc aggaaaggat
    60541 taggggagaa gcaatgacaa atcgtttatc atggcaagac tattttatgg ccaatgcaga
    60601 gctgatttcc aagcgctcta cctgtgatcg cgcttttgta ggagctgttt tggtaaagga
    60661 taaccgcatt attgccacag gttacaatgg cggtgtttct gctacggata actgcaacga
    60721 agcgggtcat tatatggaag acggtcattg tattcgcact gttcatgctg aaatgaatgc
    60781 tttgattcaa tgtgcgaaag aaggaatttc aacggacgga actgaaattt acgtgactca
    60841 ttttccttgt attaactgca ctaaggcgct tttgcaggcg gggattacaa agattaccta
    60901 taaagcacat taccgtccgc acccctttgc cattgaactg atggagaaaa aaggggttgc
    60961 ctatgtgcaa catgatgtgc ctcaaattgt tttaggaggc gataaggaac aatagaaagt
    61021 gtacctaaaa ggacggtcat aaaagatttg agccaaggcc acttttgtgg taaaatgaag
    61081 tgataaatat tttagtaaga ggtaataata atgattgaag caagtaagct taaagcaggt
    61141 atgacatttg aagcagaagg aaaattaatc cgtgtccttg aagctagcca ccacaaacca
    61201 ggtaaaggaa acactatcat gcgtatgaaa ctacgtgatg tgcgtacagg ttctactttt
    61261 gacacaactt accgcccaga tgaaaaattt gagcaagcca tcattgaaac tgtcccagca
    61321 caatacctat acaaaatgga tgacactgct tacttcatga acactgatac ttatgatcag
    61381 tacgaaattc cagttgctaa cgttgagcaa gaattgcttt acattcttga aaactcagac
    61441 gtgaaaatcc aattttatgg aagtgaagtg attggggtaa cggttccaac aactgttgaa
    61501 ttgaccgttg cggaaacaca accatctatt aaaggagcga cagtgacggg ttcagggaaa
    61561 cctgcaactc ttgagacagg acttgttgtt aacgttccag actttatcga agctggccaa
    61621 aaactaatca ttaacactgc agaaggtact tacgtttctc gtgcttaatc ctttgtcaaa
    61681 acagattagt ctaaaaaaga gaaaggaaat gctatgacaa ctgaatatat cggtgaaatc
    61741 gtcatttcac cacgagtgct tgaggttatt acggggattg ctacgacaca agttgagggc
    61801 gtccactcac tccataacaa gaaaatggca gatagcttta acaaagcaag tcttggtaaa
    61861 ggggtttatc tccagacaga agaagatgga agtgttacag cagatattta tgtttacttg
    61921 caatatggag ttaaggtccc gactgtatct atgaatattc aaaaaacagt caaatctgct
    61981 gtgtacgata tggcagaagt gcctatttct gcagttaata tccatgttga aggtattgtt
    62041 gctgaaaaga caccaaaacc agatttgaag tcactttttg atgaggattt cttggatgac
    62101 taacagcttt caaaattcaa gaagagattt gcgtgaacgt gcctttcagg ctttatttaa
    62161 catagagatg ggagctgagt tattggcagc ttctcagttt gcctatggtt atgataaagt
    62221 aacaggggag gacgctcaag tattggagct gccgattttt ttattaagtc ttgtgatggg
    62281 tgtcaataat cataaagaag agttggataa cttgatatca actcatttga aaaaaggttg
    62341 gtcgttagaa cgcttgacac taacagacaa aacgttatta cggctaggtc tttttgaaat
    62401 caagtatttt gacgaaacac cagatcgtgt tgcactaaac gaaatcattg aagtagctaa
    62461 aaaatattct gatgaaacct ctgctaaatt tattaatggc ttacttagcc aatatgtctc
    62521 ggaagctcct tcagcaaata aatcataata agtcggagca atcttaggat tgtatccgat
    62581 tttttcaatt tatgtacgaa tattaaaaga caaacaagca tactctcgca tctagaaaga
    62641 gtatgcttgt ttgtctttta gagtaattag tgattggtta tgttttgttt aaatacttgc
    62701 tcctggaagt agcgtaatcg gtaaaatata gtctttactg gttttttctt ttttaatttt
    62761 tttaatgagt atttcgacac tcaatttagc aatctcatca ataggttgac gaatggtcgc
    62821 taattgagga acatattgct ggataaatgt cgttccatca taacctatga ctttcatatc
    62881 ctctggaata gtaatgtgaa gttgtttggc tactttcata atgaggatag cagttaaatc
    62941 atcagaaacg aaaaggccat caggttttcg ggttgccaaa atggatttaa tttccatttc
    63001 gcgtctaaca ggagataggt tatttggtaa tttgatgatt tctgcacttc gtttgagctg
    63061 gtagttaaac cctagctggc gcaaccctgt gggcgaatca gaattgtcat tacctgtaat
    63121 catgacaatg ttttgacaac cgtgtttttg caaagtttgt gcggctaatt taccaccttc
    63181 aaaattatct gaagaaataa ccgggatatt tggcgccaga ttacggtcaa aagctacaat
    63241 aggagcttcg acacgctcat aatcctcaat tcccaaatta tgactggaag aaataatgcc
    63301 gtccacttga ttggccgcaa gcatttctaa gtattcgcgt tctttgacgg gattatgttc
    63361 actattgcaa ataatagttt tgtagccttg tttaaacaat tcaatttcca aatgttcaat
    63421 taattcagcg taaaagatat tgctaatgtt ggggaagata agcccaatga gttgggttga
    63481 tttaccttgc aaacttctag cgagattgtt aggcttgtag cccaattcac gcatggcctt
    63541 attcacctta ttcactgttt tttgggaaag gtagcctttt ttgttgatta ctcgcgaaac
    63601 agttgttgga ctgacacccg ccaaggctgc cacgtctgtt aattttgcga ccacttgcct
    63661 aatacctcat ttcataataa tgtccaaaag cttgtccttc tactacttgg atacctgttt
    63721 gtccttgggt tgggaaaaca cgactagtta ggactttttg cccttggtta ataaagattt
    63781 caagaatgga attgtccaca tagacattaa gtgtaacatg gctttgtggg atttggcaag
    63841 agcgcaccgt accatagtct tgggcatatt gaacccctgc ccgacttcgg tcaatgctta
    63901 actgtccttt tgttgtatcc actttcaatc ttaggccatt ccctttttgg tcggcaaata
    63961 ggagcaggtc aagctttttt tggcctggaa tcgtcaattc caattcataa cagttagaac
    64021 tgtctatttt attatgaaat aattctgctg gccctcgaag attttgtagg gctgaaacag
    64081 gtgtttgata gagaattccg tctttaatcc ttaattcttt cactaaacta agagctcctt
    64141 gatagtcata acgatctgtc ggataatcaa tatctggtag cccaatccaa gaaacggcta
    64201 gaaccctgcc atctggacta ctaaaggctt gagtggcata agcttcaaaa ccaaagtcaa
    64261 gattttgaag ggccccccca cccagcaatt ggccagtttc tggattgaag ctttcaaaaa
    64321 ttttataggt attggggtag atattttgat aatctaaatc agctttagcc agtccttgtg
    64381 ggctgaaaat caaaacaggc ttgtcatcga caaacacaag gttggggcat tcaatcatgt
    64441 attccgtacc agaatcgtca aagtccaaat cgtctataaa tcgccagttg tccacatgat
    64501 tgtccacagc tttgtaaagt ttgatttttc ctttgccatc taaaccttgg gcgccaataa
    64561 tagcatagaa ttgaccttga taagaaaaaa gctgaggatc ccgaaaatgt tctgtaacat
    64621 catcgggctg ttcaatcaaa acctgcggga ttttggaaat atttccttgt ttatccatcc
    64681 atgcgccaac ctgtaatggt gttctgaccc agttggcatc gcgaacatta ccagtgtaaa
    64741 agaggaagag cttgtcatca atagcatagg cagagcctga gtaagcccca tgactatcgt
    64801 gagcgtggtc tggcagaagg cggctccttg tttccgtaaa atggacgagg tctgtggatg
    64861 tcatgtgtac ccattgtttc agaccatgcg cagccccata aggccagttt tgataaaaaa
    64921 gatggtagcg accgttgaaa taagaaaacc cattggggtc attgagtaat cctgtcttag
    64981 gttcgacatg aaattggctg tgccatgggg attgggccat tttttcagta atagcttggt
    65041 agtcttttga gctccactct ttgtaagggc ggtagcgaat agcttgtggt agatccatca
    65101 aaatctcctt gttttatagt cgtcttcaag aatatactaa acgttttctg tttaaaaatc
    65161 aagaatttaa agcatataaa ataaaaatat gttaaacgct tgacataaaa aatattagtg
    65221 ataaaatgat agtcaagaag tgaagcggat tcactagcgt tggtcctaca cattcttagc
    65281 cacaaagctg gcagaatgga tgagggacta acaccaaatg aaaaaggaga cttttaggca
    65341 tggataatcg tcagattgca actgaagtga ttgaggcttt aggtggccga gaaaatgtga
    65401 gaagtgttgc ccactgtgca actcgccttc gcgtgatggt ttatgatgaa ggaaagattg
    65461 ataaggaaaa agcagaagct attgacaagg ttaaaggagc tttctttaac tctggtcaat
    65521 atcaaatgat ttttggaact ggtaccgtca ataacattta tgacgaagtc gttgctcttg
    65581 gtttaccaac atcatcaacc agtgagcaaa aagcagaagc aggcaaacaa ggcaatatct
    65641 tccaacgggc gattcgtacg tttggagatg tctttgttcc cattattcca gctattgtag
    65701 caacgggtct ctttatgggg gttcgtggtt tggtgaccca gccagctatt atggatttat
    65761 ttggggtgca tgagcacggg gaaaattttc tcatgtacac tcgtattcta acggatacag
    65821 cctttgtcta cttgccagct ttggtggctt ggtcagcctt tagggtcttt gggggtaatc
    65881 ctattatcgg tattgtttta ggcttgatgt tggtgtccaa tgaattgcca aacgcctggg
    65941 tagttgcctc tggtggagat gttaagccgc taaccttctt tggatttgtt cctgttgttg
    66001 gttatcaagg taccgtttta cctgccttct ttgttggtct ggtaggagct aagttggaga
    66061 aatggttgca caaaaaggtt ccagaagctt tggacttatt ggtcacaccg tttttaacgt
    66121 ttgctattat gagtatcttg ggactatttg tgattggacc agtcttccat tctcttgaaa
    66181 accttgttct ggctgggaca caggcagtct tacatttgcc gtttggcatt gctggtctta
    66241 ttgttggtgg tatccaacag ttgatcgtcg ttactggtat tcaccatatc tttaacttcc
    66301 tagaagcgca gctgattgcc aataccggaa aagatccttt caatgcttac ctaacagcag
    66361 caatagctgc tcaagctgga gctaccttag ctgttgctgt taaaaccaaa tcaccaaaat
    66421 taaaaggttt ggcttttcca tcgaccttat cagctctttt agggattact gaaccagcta
    66481 tttttggggt caatctccgt tatccaaaag tctttgtttc aggtcttatt ggtggtgcct
    66541 taggtggttg ggtcgctgga ctctttggca ttgcaggaac tggttttggg attacggtct
    66601 taccaggaac tctcctttac ttgaatggcc aattattaca ataccttgtg actatgcttg
    66661 tcggtcttgg ggtagccttt gcaattgctt atacttgggg ttatcaagat agagaaaccc
    66721 ttccgttacc agctgtcgaa gttgatcaaa cggctgatca gccagcctta gcagaggaaa
    66781 ctttatatag tcctttgaat ggaacagttg tagatttagc agctgtttca gaccctgttt
    66841 tttcatcagg tgctatgggt caaggcttag caattaagcc agaagataat accctatact
    66901 caccagttga tggtaaagtt gaaattgtct ttgaaacagg tcatgcctat gctataacgt
    66961 caagtcaagg agcagaagtg ttacttcata ttggtattga taccgtgtcg atggcaggag
    67021 atggctttga atctcttgta gcagtaggtc aggcggttaa aagaggtgat cttcttggac
    67081 actttgatcc tagcaagatt gcagaagctg gactagatga caccaccatg atgattgtga
    67141 ccaacagcgc tgactatcaa agcgtggaca ttcttgctca aggacatatt ttgattggtg
    67201 atcaagtggc acttatcaaa taaggacaaa agagctaact aagcagctct tttgtcctgc
    67261 catgaatggc aggttggcaa aaaaatgaga aaagcctaaa aaccttaaat ttgtgttatt
    67321 ttacctatac tttgtacctt gtttttttta ataaagtgtt gttatactta aggcgaacta
    67381 taggaatgcg cttacatata tggtatatca actgggaagc catgacttag taccaaaaat
    67441 aaggagtgtc caaatggata aacatttgtt ggtaaaaaga acactagggt gtgtttgtgc
    67501 tgcaacgttg atgggagctg ccttagcgac ccaccatgat tcactcaata ctgtaaaagc
    67561 ggaggagaag actgttcagg ttcagaaaga attatcttct atagatagct tgcattatct
    67621 gtcagagaat agcaaaaaag aatttaaaga agaactctca aaagcggggc aagaatctca
    67681 aaaggtcaaa gagatattag caaaagctca gcaggcagat aaacaagctc aagaacttgc
    67741 caaaatgaaa attcctgaga aaatactgat gaaaccgtta catggtcctc tctacggtgg
    67801 ttactttaga acttggcatg acaaaacatc agatccaaca gaaaaagaca aagttaactc
    67861 gatgggagag cttcctaaag aagtagatct agcctttatt ttccacgatt ggacaaaaga
    67921 ttatagcctt ttttggaaag aattggccac caaacatgtg ccaaagttaa acaagcaagg
    67981 gacacgtgtc attcgtacca ttccatggcg tttcctagct ggaggtgata acagtggtat
    68041 tgcagaagat accagtaaat acccaaatac accagaggga aataaagctt tagccaaagc
    68101 tattgttgat gaatatgttt ataagtacaa ccttgatggc ttagatgtgg atgttgaaca
    68161 tgatagtatt ccaaaagtaa atggagaagc tagtgacgaa aatctcaagc gatctattga
    68221 tgtttttgaa gaaattggga aattaattgg accaaaaggt gttgataaat cgcggttatt
    68281 tattatggat agcacctata tggctgataa aaacccattg attgagcgag gagctcctta
    68341 tattgatttg ttattggtac aagtctatgg cgcaagagga gaacaaggtg agtttcaaaa
    68401 cgataccaag ttagttaccg agactcctga agaacgatgg caaggttata gcaagtatat
    68461 tcgtcctgaa caatacatga ttggtttttc tttctatgag gaaagagcag gcagcggcaa
    68521 tctttggtat gatattaatt ctcgaaagga cgatgacaaa gcaaatggaa ttaacactga
    68581 cataactgga acgcgtgccg aacggtatgc aaggtggcaa cctaagacag gtggggttaa
    68641 gggaggtatc ttctcctacg ctattgaccg tgatggtgta gctcatcaac ccaaacaaat
    68701 agctgaaaaa gataaacaga atgtaaaaaa taatcagcct cagattccag aaattactga
    68761 taacattttc cactcagatt atagtgtctc caaggcatta aagacagtta tgctaaaaga
    68821 taagtcgtat gatctgattg atgagaaaga tttcccagat aaggctttgc gagaagctgt
    68881 gatggcgcag gttggaacta gaaaaggtga tttggaacgt ttcaatggca cattgcgatt
    68941 ggataatcca gcgattcaaa gtttagaagg tctaaataaa tttaaaaaat tagctcaatt
    69001 agacttgatt ggcttatctt gcattacaaa gcttgaccaa tctgttttac ccgctaatat
    69061 gaagccaggc aaagatacct tggaaacagt tcttgaaacc tataaaaagg ataacaaaga
    69121 agaacctgct actatcccac cagtatcttt gaaggtttct ggtttaactg gtctgaaaga
    69181 attagatttg tcaggttttg accgtgaaac cttggctggt cttgatgccg ctactctaac
    69241 gtctttagaa aaagttgata tttctggcaa caaacttgat ttggctccag gaacagaaaa
    69301 tcgacaaatt tttgatacta tgctatcaat tatcagcaat catgttggaa gcaatgaaca
    69361 aacagtgaaa tttgacaagc aaaaaccaac tggacattac ccagatacct atgggaaaac
    69421 tagtctgcgc ttaccagtgg caaatgaaaa agttgatttg caaagccagc ttttgtttgg
    69481 gactgtgacg aatcaaggaa ccctaatcaa tagcgaagca gactataagg cttaccaaaa
    69541 tcataaaatt gctggacgta gctttgttga ttcaaactat cattacaata actttaaagt
    69601 ttcttatgag aactataccg ttaaagtaac tgattccaca ttgggaacca ctactgacaa
    69661 aacgctagca actgataaag aagagaccta taaggttgac ttctttagcc cagcagataa
    69721 gacaaaagct gttcatactg ctaaagtgat tgttggtgac gaaaaaacca tgatggttaa
    69781 tttggcagaa ggcgcaacag ttattggagg aagtgctgat cctgtaaatg caagaaaggt
    69841 atttgatggg caactgggca gtgagactga taatatctct ttaggatggg attctaagca
    69901 aagtattata tttaaattga aagaagatgg attaataaag cattggcgtt tcttcaatga
    69961 ttcagcccga aatcctgaga caaccaataa atctattcag gaagcaagtc tacaaatttt
    70021 taatatcaaa gattataatc tagataattt gttggaaaat cccaataaat ttgacgatga
    70081 aaaatattgg attactgtag atacttacag tgcacaagga gagagagcta ctgcattcag
    70141 taatacatta aataatatta ctagtaaata ttggcgagtt gtctttgata ctaaaggaga
    70201 tagatatagt tcgccagtag tccctgaact ccaaatttta ggttatccgt tacctaacgc
    70261 cgacactatc atgaaaacag taactactgc taaagagtta tctcaacaaa aagataagtt
    70321 ttctcaaaag atgcttgatg agttaaaaat aaaagagatg gctttagaaa cttctttgaa
    70381 cagtaagatt tttgatgtaa ctgctattaa tgctaatgct ggagttttga aagattgtat
    70441 tgagaaaagg cagctgctaa aaaaataaac aaagtaactt tcttagatag caacattcag
    70501 attaaattaa caaaatgtga ctatgataaa ggtttgctgg aattgattaa ccaaaagact
    70561 aaaaatctga gatgaatagt cccagatttt tagtctttta taggttttga tgacataaag
    70621 ctaaataatc gttagactac cagaaagtgg cgcttgtcct tgagacatgg ctgtcttgat
    70681 aagatcctgt gtcatcataa agataaaaaa gaacaagaaa aaggagaaaa catgggaaaa
    70741 ttatatggaa gcattgaagc tggtgggaca aagtttgtct gtgccgtggg tgatgaggag
    70801 tttacagtgg tggataaaac acaatttccg accaccacac cagaagaaac catcgcgcga
    70861 accatcgctt attttaaagc ttttgaggca gatttggctg gtattgctat tggttctttt
    70921 ggaccaattg atattgatcc gtcgtcagag acttacggtt acatcacaac cactcctaag
    70981 tcaggctggg ctaatgtgga tttgttagga caactttcgg ctgcttttaa gattcctttt
    71041 gatgtgacaa cagatgttaa tagctctgct tatggtgagg tgcttgctcg tcctggtgtg
    71101 gaaagtttgg tctattacac cataggtact ggtattgggg cgggagctat tcaacatggc
    71161 cactttattg ggggtttagg tcatacagaa gcgggtcata cctatgtcat gccccatcct
    71221 gatgatatgg ccaagggatt tttaggtgtt tgcccttttc ataaagggtg tctggaaggg
    71281 atggcagcag gtccaagtat tgaggccaga acgggagtga gaggtgaacg gcttgatcag
    71341 gaagctgatg tttgggacat tcaagccttc tacattgccc aagcagcgct gcaagcaact
    71401 atgctttacc gtcctcaagt gattgttttt ggcggaggtg tcatggcgca agaacatatg
    71461 gtgttgcgcg tgcatgataa attcactacc cttttaagcg gttatttgcc agtccctgat
    71521 ttgacagact acattgttac tccagctgtt gctgataatg gctccgctac tctgggaaat
    71581 tttgctttgg ccaagttggc tgcacaagga aaataggatc tgtttttgcc tgcttgtcta
    71641 gtaaaagaaa gcgcagtcag ctagaacatg ctataataaa cagagattaa catcagaagc
    71701 gaggaatatt atgtcagaac cattatttct aaaatcaact atgcacgaca ggatttgggg
    71761 tggcaccaag ttgagagatg tctttgctta caacatccca agtgacacca caggtgagta
    71821 ttgggctatt tctgctcatc ctaatggtgt ttcgacagtt actaatggac gttatcaagg
    71881 acaaccttta aacacattat atgcgcaaga gccggccttg tttgggaatc caaaggaaga
    71941 agtttttcca ctgttaacta agattttaga tgctaatgac tggctaagtg tccaagttca
    72001 tcctgatgat gcttatggac gtgaacatga aggagaatta ggcaagacag aatgctggta
    72061 tattatttct gccgaagagg gttctgaaat tgtatacggc catcaggcca agtccaaaga
    72121 agaccttcgt gccatgattg aagcaggcgc ttgggatgat ttgctgactc gtgtcccagt
    72181 caaagcaggc gattttttct atgttccaag tggcaccatg catgcgatcg gcaagggaat
    72241 tcttatttta gaaacccagc agtcatctga taccacttat cgggtttatg attttgaccg
    72301 taaggacgtt aatggtaatc ttcgtgacct tcatattgaa aagtctattg atgtcttaac
    72361 gattggtaag ccagaaaata gcgtgccagc cactatggtt ttggataata tggtagcaac
    72421 aactttagtc tcaacaccat ttttcactgt ttacaaatgg gtaactagtc aaatggttga
    72481 catgaaacaa gctgcgcctt atcttttagt gagtgtttta aaaggtcaag gaaaactcta
    72541 tgtggaccag aaggcttatg agctagaaaa aggcatgcac tttatcttgc ctaacgatgt
    72601 taaatcgtgg tcatttgatg gtcaattaga aatgattgtg agtcacccca atcaactcgt
    72661 ttaataccat ggtatcaata tgagaaaaaa ggataaaatt atgactctct gtttctctga
    72721 taacttta
//
LOCUS       DAUDWO010000003        60543 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.003, whole genome shotgun sequence.
ACCESSION   DAUDWO010000003 DAUDWO010000000
VERSION     DAUDWO010000003.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 60543)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 60543)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..60543
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.003"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            92..904
                     /locus_tag="VHC05_000150"
     CDS             92..904
                     /locus_tag="VHC05_000150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEQ5401500.1"
                     /translation="MTKKLIAIDLDGTLLHHDNTISTYTQKTIKAVQDKGHHVIISTG
                     RPYRMALDYYLQLNLKTPIITFNGALTHMPEQKWAYEHNVTLDKGYLLRLLQYQDDFQ
                     MDFIASEYRKNVYITMTNPESIDPQLFGVDEITQDMALEITKITRNPNALLMQTRHED
                     KYALAKNMRAFFKDEIEIDSWGGPLNILEISSKNVNKAYALNYLLGIYNMDKKDLIAF
                     GDEHNDTEMLAFAGTGYAMKNASPVLLPYADQQLNFSNEEDGVAKKLEELFL"
     gene            1256..2248
                     /gene="manX"
                     /locus_tag="VHC05_000151"
     CDS             1256..2248
                     /gene="manX"
                     /locus_tag="VHC05_000151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIAB"
                     /protein_id="HEQ5401501.1"
                     /translation="MGIGIIIASHGKFAEGIHQSGSMIFGEQEKVQVVTFMPNEGPDD
                     LYGHFNNAIQQFDADDEILVLADLWSGSPFNQASRVAGENPDRKMAIITGLNLPMLIQ
                     AYTERLMDAGAGVEQVAANIIKESKDGIKALPEDLNPVEETAATEKVVNALQGAIPAG
                     TVIGDGKLKINLARVDTRLLHGQVATAWTPASKADRIIVASDEVAQDDLRKQLIKQAA
                     PGGVKANVVPISKLIEASKDPRFGNTHALILFQTPQDALRAVEGGVEINELNVGSMAH
                     STGKTMVNNVLSMDKEDVATFEKLRDLGVTFDVRKVPNDSKKNLFELIQKANIK"
     gene            2337..3146
                     /locus_tag="VHC05_000152"
     CDS             2337..3146
                     /locus_tag="VHC05_000152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter subunit
                     IIC"
                     /protein_id="HEQ5401502.1"
                     /translation="MSDISIISAILVVIIAFFAGLEGILDQFQMHQPLVACTLIGLVT
                     GHLEAGVILGGTLQMLALGWANIGAAVAPDAALASVAAAIIMVKSGDFTQKGITFAYS
                     TAIPLAVAGLFLTMIVRTLSTALVHAGDKAAAEGNFAGIERFHFIALLLQGLRIAVPA
                     ALLVAVPTSAVQSVLNAMPNWLNEGMQIGGAMVVAVGYAMVINMMATREVWPFFALGF
                     ALAAISQLTLIAMGVIGVAIAFIYLNLSKKGGNGGNAAGSADPIGDILEDY"
     gene            3163..4074
                     /locus_tag="VHC05_000153"
     CDS             3163..4074
                     /locus_tag="VHC05_000153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000139230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEQ5401503.1"
                     /translation="MTEQIKLTKSDRQRVWWRSQFLQGSWNYERMQNMGWAYALIPAL
                     KKLYTSPEDRAAALERHMEFFNTHPYVAAPIIGVTLALEEERANGTPIDDKAIQGVKI
                     GMMGPLAGIGDPVFWFTVRPILGALGASLASTGNIVGPLLFFFGWNLIRMAFLWYTQE
                     FGYKAGSEITKDMSGGILQDITKGASILGMFILAVLVQRWVSINFTIDLPGKQLSDGA
                     YVVFPDGAVKGAELKTILANAIGGMSLDKVQAQTLQGQLDSLIPGLAGLLLTFLCMWL
                     LKKKVSPIAIIIGLFAFGILAHLAGIM"
     gene            4188..4547
                     /locus_tag="VHC05_000154"
     CDS             4188..4547
                     /locus_tag="VHC05_000154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF956 family protein"
                     /protein_id="HEQ5401504.1"
                     /translation="MAQSLNTSVEYKTKAVSYLGLGGKVGHILLGDKALEFYNDKNVN
                     DYIQIPWTAINHIGANVSRKKVSRHFEIFTDQGKFLFASGDSGKILKITRQHIGNEKV
                     ITLPTLMQTFINKFFRH"
     gene            4939..6216
                     /gene="serS"
                     /locus_tag="VHC05_000155"
     CDS             4939..6216
                     /gene="serS"
                     /locus_tag="VHC05_000155"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HEQ5401505.1"
                     /translation="MLDLKRIRTDFDTVAAKLKNRGVSEDTLTHLKELDEKRRTLLVQ
                     SEELKAERNIASAAIAQAKRQKEDATQQIADMQKVSADIKTIDNQLVAIDQQVTDIIT
                     VLPNTPHDSVPVGADEEDNVEIRRWGTPRDFDFEVKAHWDLGEDLDILDWERGAKVTG
                     ARFLFYKNLGARLERALYNFMLDEHIKEGYQEIITPYMVNHDSMFGTGQYPKFKEDTF
                     ELADTNFVLIPTAEVPLTNYYRGEILDGKELPIYFTAMSPSFRSEAGSAGRDTRGLIR
                     LHQFHKVEMVKFAKPEESYQELEKMTANAENILQKLGLPYRVISLCTGDMGFSAAKTY
                     DLEVWIPAQNTYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTV
                     AAILENYQNEDGSVTIPEVLRPYMGGETVISPK"
     gene            complement(6449..7219)
                     /locus_tag="VHC05_000156"
     CDS             complement(6449..7219)
                     /locus_tag="VHC05_000156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyl transferase
                     subunit alpha"
                     /protein_id="HEQ5401506.1"
                     /translation="MTDVSRVLKEARDQGRLTTLDYANLIFDDFMELHGDRHFSDDGA
                     IVGGLAYLAGQPVTVIGIQKGKNLQDNLARNFGQPNPEGYRKALRLMKQAEKFGRPVV
                     TFINTAGAYPGVGAEERGQGEAIAKNLMEMSDLKVPIIAIIIGEGGSGGALALAVADQ
                     VWMLENTMYAVLSPEGFASILWKDGSRATEAAELMKITAGELYQMGIVDRIIPEHGYF
                     SSEIVDIIKANLIEQITSLQAKPLDQLLDERYQRFRKY"
     gene            complement(7216..8082)
                     /locus_tag="VHC05_000157"
     CDS             complement(7216..8082)
                     /locus_tag="VHC05_000157"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit beta"
                     /protein_id="HEQ5401507.1"
                     /translation="MALFRKKDKYIRITPNNSLKGSVSHNVPEVPDELFAKCPACKHM
                     IYKKDLGLAKICPTCSYNFRISAQERLTLTVDEGSFQELFTSIETKDPLRFPGYQEKL
                     QKAKETTGLHEAVLTGKAMVKGQQIALAIMDSHFIMASMGTVVGEKITRLFELAIEEN
                     LPVVIFTASGGARMQEGIMSLMQMAKVSAAVKRHSNAGLFYLTILTDPTTGGVTASFA
                     MEGDIILAEPQSLVGFAGRRVIETTVRENLPDDFQKAEFLQDHGFVDAIVKRTELRDK
                     IAHLVAFHGGGQ"
     gene            complement(8091..9455)
                     /locus_tag="VHC05_000158"
     CDS             complement(8091..9455)
                     /locus_tag="VHC05_000158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003056649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="HEQ5401508.1"
                     /translation="MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTIL
                     ADEAICIGPARSKESYLNMNSVLSAAIVTGAQAIHPGFGFLSENSKFATMCEEMNIKF
                     IGPSASVMDKMGDKINARSEIIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKAS
                     AGGGGKGIRKVETEADLEAAFNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAY
                     GNIIHLGERDCSLQRNNQKVLEESPSIAIGNTLRHEMGQAAVRAAEAVAYENAGTIEF
                     LLDEDSEKFYFMEMNTRIQVEHPVTEFVTGVDIVKEQIKIAAGQPLAINQEDITITGH
                     AIECRINAENTAFNFAPSPGKITDLYMPSGGVGLRVDSAVYNGYAIPPYYDSMIAKII
                     VHGSNRFDALMKMQRALVELEIEGIITNTDFQLDLISDKRVIAGDYDTSFLMETFLPH
                     YNKD"
     gene            complement(9487..9909)
                     /gene="fabZ"
                     /locus_tag="VHC05_000159"
     CDS             complement(9487..9909)
                     /gene="fabZ"
                     /locus_tag="VHC05_000159"
                     /EC_number="4.2.1.59"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002922202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="HEQ5401509.1"
                     /translation="MMDIREIQAALPHRYPMLLVDRVLEVSDDHIVAIKNVTINEPFF
                     NGHFPHYPVMPGVLIMEALAQTAGVLELSKEENKGKLVFYAGMDKVKFKKQVVPGDQL
                     VMTATFIKRRGTIAVVEARAEVDGKLAASGTLTFACGQ"
     gene            complement(9906..10406)
                     /locus_tag="VHC05_000160"
     CDS             complement(9906..10406)
                     /locus_tag="VHC05_000160"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="HEQ5401510.1"
                     /translation="MNIQEIKDLMAQFDTSSLREFLFKTNEGELIFSKNEQHLNASTS
                     NQEHAVPVPQVQLVPNPTASEASSPASVKDVPVEEQPQAESFVAEGDIVESPLVGVAY
                     LAASPDKPPFVAVGDTVKKGQTLVIIEAMKVMNEVPAPCDGVITEILVSNEDVIEFGQ
                     GLVRIK"
     gene            complement(10408..11640)
                     /gene="fabF"
                     /locus_tag="VHC05_000161"
     CDS             complement(10408..11640)
                     /gene="fabF"
                     /locus_tag="VHC05_000161"
                     /EC_number="2.3.1.179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012679081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="HEQ5401511.1"
                     /translation="MTFKRVVVTGYGLTSPIGHDPETFWNNLKAGQIGIGPITKFDTT
                     DYAVKNAAEIQDFPFDKYFVKKDLNRFDRYSLYALYAAKEAINHADLNIEMIDSDRFG
                     VIVASGIGGIAEIEEQVIRLHEKGPKRVKPMTLPKALPNMAAGNVAMSLKAQGVCKSI
                     NTACASSNDAIGDAFRAIKFGTQDVMIVGGSEAAITKFAIAGFQSLTALSTTEDPSRS
                     SIPFDKDRNGFIMGEGSGMLVLESLEHAQEREATILAEIVGYGNTCDAYHMTSPNPEG
                     LGARKAIHLALQEAGIEASAINYVNAHGTSTPANEKGESQAIVAVLGKDVPVSSTKSF
                     TGHLLGAAGAIEAIATIEAMRHNYVPMTAGTQALSEDIEANVIFGEGKETAINYAISN
                     TFGFGGHNAVLAFKCWEE"
     gene            complement(11655..12389)
                     /gene="fabG"
                     /locus_tag="VHC05_000162"
     CDS             complement(11655..12389)
                     /gene="fabG"
                     /locus_tag="VHC05_000162"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017771521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="HEQ5401512.1"
                     /translation="MEIKGKNIFITGSTRGIGLAMAHQFASLGANIVLNGRSAISEEL
                     VASFTDYGVTVVTISGDVSEASEAKRMVNEAIESLGSIDVLVNNAGITNDKLMLKMTE
                     EDFERVLKINLTGAFNMTQSVLKPMIKARQGAIINVSSVVGLTGNIGQANYAASKAGM
                     IGFTKSVAREVAARNICVNAIAPGFIESDMTGVLPEKMQEQILSQIPMKRIGKAQEVA
                     HLASFLVEQDYITGQVIAIDGGMTMQ"
     gene            complement(12379..13317)
                     /gene="fabD"
                     /locus_tag="VHC05_000163"
     CDS             complement(12379..13317)
                     /gene="fabD"
                     /locus_tag="VHC05_000163"
                     /EC_number="2.3.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACP S-malonyltransferase"
                     /protein_id="HEQ5401513.1"
                     /translation="MTKTAFLFAGQGAQKLGMARDFYDNFAIVRKTFDQASQVLGYDL
                     RRLIDSDELKLNQTSYTQPAILTSSIAIYRVLGLHHVKPDMVAGLSLGEYSALVASGA
                     LSFEDTLSLVAKRGRLMEEAAPQGSGKMVAVMNTDVQVIEEVCQIAAKHGVVAPANYN
                     TPSQIVIGGQTDAVNVAVELLKERGVKRLIPLNVSGPFHTALLEPASRLLAKELERYN
                     FSDFKIPLVGNTEANIMEKDRIPELLARQVMEPVRFYDSVATLVESGITQFIEVGPGK
                     VLTGFVKKIDKNLLCTSVENMVSLRLFLDREDIHGN"
     gene            complement(13342..14313)
                     /gene="fabK"
                     /locus_tag="VHC05_000164"
     CDS             complement(13342..14313)
                     /gene="fabK"
                     /locus_tag="VHC05_000164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-[acyl-carrier-protein] reductase FabK"
                     /protein_id="HEQ5401514.1"
                     /translation="MKTRITELLNIDYPIFQGGMAWVADGDLAGAVSNAGGLGIIGGG
                     NAPKEVVKANIDRVKAITDRPFGVNIMLLSPFADDIVDLVIEEGVKVVTTGAGNPGKY
                     MERLHQAGIIVVPVVPSVALAKRMEKLGVDAVIAEGMEAGGHIGKLTTMSLVRQVVEA
                     VSIPVIAAGGIADGHGAAAAFMLGAEAVQIGTRFVVAKESNAHQNFKDKILAAKDIDT
                     VISAQVVGHPVRSIKNKLTSAYAKAEKAFLIGQKTATDIEEMGAGSLRHAVIEGDVVN
                     GSVMAGQIAGLVRKEESCETILKDIYYGAARVIQNEAKRWQSVSIEK"
     gene            complement(14514..14738)
                     /locus_tag="VHC05_000165"
     CDS             complement(14514..14738)
                     /locus_tag="VHC05_000165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002938891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HEQ5401515.1"
                     /translation="MAVFEKVQEIIVEELGKETEEVTLETTFDDLDADSLDVFQVISE
                     IEDAFDIQIETEEGLNTVGDLVAYVEEKSK"
     gene            complement(14799..15773)
                     /locus_tag="VHC05_000166"
     CDS             complement(14799..15773)
                     /locus_tag="VHC05_000166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III"
                     /protein_id="HEQ5401516.1"
                     /translation="MIFSKISQVAHYVPQQLVTNNDLANIMDTSHEWIFSRTGIAERH
                     ISRDEMTSDLAIQVADQLLTQSGLKADAIDFIIVATISPDATMPSTAAKVQAAIAATS
                     AFAFDMTAACSGFVFALAMADKLIASGAYQNGMVIGAETLSKLVNWQDRATAVLFGDG
                     AGGVLLEASKDKHVLAETLHTDGARCQSLISGETSLSSPYSIGKKAIATIQMDGRAIF
                     DFAIRDVSKSILTLMAQSDITKDDIDYCLLHQANRRILDKIARKIDVPREKFLENMMR
                     YGNTSAASIPILLSEAVQKGQIRLDGTQKILLSGFGGGLTWGSLIVKI"
     gene            complement(15774..16208)
                     /locus_tag="VHC05_000167"
     CDS             complement(15774..16208)
                     /locus_tag="VHC05_000167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEQ5401517.1"
                     /translation="MEYDKINHYLVDIFNRILVIEEMSLKTSQFNDVSLKEMHTIEII
                     GKYDQVTPSDIARELMVTLGTVTTSLNKLEAKGYIARTRSRSDRRVVYLSLTKRGRLL
                     DRLHAKFHKNMVGHVIADMSDEEMQALVRGLGNLHQFLEDLV"
     gene            complement(16282..17073)
                     /locus_tag="VHC05_000168"
     CDS             complement(16282..17073)
                     /locus_tag="VHC05_000168"
                     /EC_number="4.2.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase"
                     /protein_id="HEQ5401518.1"
                     /translation="MQFKHIIFDVVDDLATLTLNRPEVSNGFNIPICQEILVALAEVK
                     RDTSVRFLLIKAVGKVFSVGGDLVEMQEAVAKDNVQSLVKIAELVQEISFAIKHLPKP
                     VILCADGAVAGAAFNIALAVDFCIASTQTKFIQAFVNVGLAPDAGGLFLLTRAVGLNR
                     ATHLVMTGEGITADKGVDYGFVYRTAESDKLDKVCLQLLKRLRRGSSNSYAGMKSLVW
                     QSFFTGWEDYAKAELAIQEELAFKEDFKEGVIAFGERRRPNFQGK"
     gene            complement(17293..18429)
                     /gene="dnaJ"
                     /locus_tag="VHC05_000169"
     CDS             complement(17293..18429)
                     /gene="dnaJ"
                     /locus_tag="VHC05_000169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaJ"
                     /protein_id="HEQ5401519.1"
                     /translation="MNNTEYYDRLGVSKDASQDDIKKAYRKMSKKYHPDINKEAGAEQ
                     KYKDVQEAYETLSDSQKRAAYDQYGAAGAQGGFGGGAGGFGGFDGGGFGGFEDIFSSF
                     FGGGGSRNPNAPRQGDDLQYRVNLSFEEAVFGVEKEVSYNREATCGTCLGSGAKPGTA
                     PVTCRKCHGSGVMTIDTQTPLGMMRRQVTCDICHGSGKEIKEPCQTCHGTGHEKQAHK
                     VSVKIPAGVETGQQIRLQGQGEAGFNGGPYGDLFVILNVLPSKQFERNGSTIYYSLDI
                     SFTQAALGDTVEIPTVHGDVEMAIPAGTQTGKTFRLKGKGAPKLRGGGQGDQHVTVNI
                     VTPTKLNDAQREALQAFAEASGEKMLHPKKKGFFDKVKDALEDI"
     gene            complement(18710..20536)
                     /gene="dnaK"
                     /locus_tag="VHC05_000170"
     CDS             complement(18710..20536)
                     /gene="dnaK"
                     /locus_tag="VHC05_000170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018375525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaK"
                     /protein_id="HEQ5401520.1"
                     /translation="MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKN
                     GEIIVGDAAKRQAVTNPETVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAE
                     DYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGMDKTDK
                     DEKILVFDLGGGTFDVSILELGDGVFDVLATAGDNKLGGDDFDQKIIDFLVAEFKKEN
                     GIDLSQDKMALQRLKDAAEKAKKDLSGVTQTQISLPFITAGSAGPLHLEMSLSRAKFD
                     DLTRDLVERTKTPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKS
                     VNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK
                     SQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDK
                     NGIVSVKAKDLGTQKEQHIVIKSNDGLSEEEIDRMMKDAEANAEADAKRKEEVDLKNE
                     VDQAIFATEKTIKETEGKGFDTERDAAQSALDELKAAQESGNLDDMKAKLEALNEKAQ
                     ALAVKMYEQAAAAQQAAQGAEGAQANDSANNDDVVDGEFTEK"
     gene            complement(20717..21289)
                     /gene="grpE"
                     /locus_tag="VHC05_000171"
     CDS             complement(20717..21289)
                     /gene="grpE"
                     /locus_tag="VHC05_000171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="HEQ5401521.1"
                     /translation="MAVFNKLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEETP
                     EKSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDN
                     LERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDE
                     HPADSIAEVFQKGYKLHERLLRPAMVVVYN"
     gene            complement(21292..22326)
                     /gene="hrcA"
                     /locus_tag="VHC05_000172"
     CDS             complement(21292..22326)
                     /gene="hrcA"
                     /locus_tag="VHC05_000172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001872861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heat-inducible transcriptional repressor HrcA"
                     /protein_id="HEQ5401522.1"
                     /translation="MITQRQNDILNLIVELFTQTHEPVGSKALQRTIDSSSATIRNDM
                     AKLEKLGLLEKAHTSSGRMPSPAGFKYFVEHSLRLDSIDEQDIYHVIKTFDFEAFKLE
                     DMLQKASHILAEMTGYTSVILDVEPARQRLTGFDVVQLSNHDALAVMTLDESKPVTVQ
                     FAIPRNFLTRDLIAFKAIVEERLLDSSVIDIHYKLRTEIPQIVQKYFVTTDNVLQLFD
                     YVFSELFLETVFVAGKVNSLTYSDLSTYQFLDNEQQVAISLRQSLKEGEMASVQVADS
                     QEAALADVSVLTHKFLIPYRGFGLLSLIGPIDMDYRRSVSLVNIIGKVLAAKLGDYYR
                     YLNSNHYEVH"
     gene            complement(22461..23030)
                     /locus_tag="VHC05_000173"
     CDS             complement(22461..23030)
                     /locus_tag="VHC05_000173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 73 protein"
                     /protein_id="HEQ5401523.1"
                     /translation="MRKRLKFPYFLTLLACFLLLIVCPLLSSQRIASADKEVRVNYSQ
                     KQFITKMGKEVKPSAKYYGIRPSILIAQILLETHDGKTLLASKYHNLFSKKATPGQAA
                     ITLKSPKQTNQNVRYAIYKDDASAIRDYLRMLRQGKEVDKRLYRNLATEKGYKAPAKS
                     LQKYLHYTDKTYARRLIQAIESNDLTNYD"
     gene            complement(23027..23770)
                     /locus_tag="VHC05_000174"
     CDS             complement(23027..23770)
                     /locus_tag="VHC05_000174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="HEQ5401524.1"
                     /translation="MKHNHFKLLLQTLVVLLFVGGIYLFIKPEKQATKTPSSQQASSQ
                     KVVKNSKESTGLPKVSPKDWELILVNRDHMTEELSPELVDVNGVSVDKRIEQATADFL
                     AAAQAIDPQEHLISGYRSVAYQAELYQSYIKKEMANDPTLTQEAAEALVQTYLQPPGA
                     SEHHTGLAIDMSTVDTLNASDPSVSKAVQKIAPDYGFVLRFPEGKKTSTGVDYEDWHY
                     RYVGKASARYMAQHNLTLEEYIAALKEKR"
     gene            complement(23760..24467)
                     /locus_tag="VHC05_000175"
     CDS             complement(23760..24467)
                     /locus_tag="VHC05_000175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEQ5401525.1"
                     /translation="MTKTRLYIARHGKTMFNTIGRAQGWSDTPLTKKGEEGIRELGLG
                     LKDATIPFKAAFSSDSGRTMQTIEIILRESENEFLPYTKDNRIREWCFGSLEGTYDSE
                     LFLGVLPRTKAFENRDNLRDVPYSELAESILEVDTANWAEPWEVLRKRIWEGFEAIAL
                     SIQNAGGGNALVVSHGMTIGTFLWLIDPDRDKQYIDNGSVTVVEFDDGQFTIKTIGDM
                     SYRYRGREIIEAMSDEA"
     gene            complement(24859..25098)
                     /locus_tag="VHC05_000176"
     CDS             complement(24859..25098)
                     /locus_tag="VHC05_000176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HEQ5401526.1"
                     /translation="MIWSLIVGAFIGMIAGKMTEKSQSMGCFTNIIAGLIGSAVGQRL
                     FGDWGIQLAGMAIFPSILGAAIVIVLVSAIFGKRY"
     gene            complement(25317..25532)
                     /locus_tag="VHC05_000177"
     CDS             complement(25317..25532)
                     /locus_tag="VHC05_000177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401527.1"
                     /translation="MIVADSNKLKYFVSEKKAVGLSQAAFLYVMLVTVYKKTIIYAKI
                     RLTGIALEPSGVSDVYLMNHHVCLHYY"
     gene            complement(25529..26968)
                     /gene="gatB"
                     /locus_tag="VHC05_000178"
     CDS             complement(25529..26968)
                     /gene="gatB"
                     /locus_tag="VHC05_000178"
                     /EC_number="6.3.5.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatB"
                     /protein_id="HEQ5401528.1"
                     /translation="MNFETIIGLEVHVELNTNSKIFSPSSAHFGEDPNANTNVIDWSF
                     PGVLPVMNKGVIDAGIQAALALNMDIHKEMHFDRKNYFYPDNPKAYQISQFDEPIGYN
                     GWIDIKLEDGSTKKIRIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMR
                     SPEEAYAYLTALKEIIQYTGISDVKMEEGSMRVDANISLRPYGQEQFGTKTELKNLNS
                     FSNVRKGLEFEVERQAKLLRSGGVIRQETRRYDEANKGTILMRVKEGAADYRYFPEPD
                     LPLYEIDDAWIDEMRAQLPQFPAQRRAKYEEELGLSAYDASQLTATKALSDFFETAVS
                     LGGDAKQVSNWLQGEVAQFLNAEGKTIEEIRLTPDNLVEMIAIIADGTISSKMAKKVF
                     VHLAKNGGSARAYVEKAGLVQISDPAVLVPIIHQVFADNEAAVADFKSGKRNADKAFT
                     GFLMKATKGQANPQVAQQLLAQELQKLRD"
     gene            complement(26968..28434)
                     /gene="gatA"
                     /locus_tag="VHC05_000179"
     CDS             complement(26968..28434)
                     /gene="gatA"
                     /locus_tag="VHC05_000179"
                     /EC_number="6.3.5.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatA"
                     /protein_id="HEQ5401529.1"
                     /translation="MSFNHKTIEELHDLLVAKEISATELTQKTLEDIKSREEAVGSFI
                     TVSEEAALKQAAAIDAKGIDADNLMSGIPLAVKDNISTKGILTTAASKMLYNYEPIFD
                     ATSVANAYAKDMIVIGKTNMDEFAMGGSTETSYFKKTKNAWDHTKVPGGSSGGSATAV
                     ASGQVRLSLGSDTGGSIRQPAAFNGVVGLKPTYGTVSRYGLIAFGSSLDQIGPFAPTV
                     KENAQLLNVIASSDVKDATSAPVRIADYTSKIGRDIKGMKIALPKEYLGEGIDPEIKE
                     TVLAAAKQFEALGATVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGFRADDA
                     KNLDEIYVNTRSQGFGDEVKRRIMLGTFSLSSGYYDAYFKKAGQVRTLIIEDFDKVFA
                     DYDLILGPTTPTVAFGLDTLNHDPVAMYLADLLTIPVNLAGLPGISIPAGFVDGLPVG
                     LQLIGPKYTEETIYQAAAAFEAVTDYHKQQPIIFGGDK"
     gene            complement(28434..28736)
                     /gene="gatC"
                     /locus_tag="VHC05_000180"
     CDS             complement(28434..28736)
                     /gene="gatC"
                     /locus_tag="VHC05_000180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008086915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatC"
                     /protein_id="HEQ5401530.1"
                     /translation="MKISEEEVRHVAKLSKLSFSESETTTFATTLSKIVDMVELLNEV
                     DTEGVAITTTMADKKNVMRQDVAEEGTDRALLFKNVPEKENHFIKVPAILDDGGDA"
     gene            complement(28968..29307)
                     /locus_tag="VHC05_000181"
                     /pseudo
     CDS             complement(28968..29307)
                     /locus_tag="VHC05_000181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106617.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate dikinase"
     gene            complement(29751..30305)
                     /locus_tag="VHC05_000182"
     CDS             complement(29751..30305)
                     /locus_tag="VHC05_000182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HEQ5401531.1"
                     /translation="MRALISIDYTNDFVADDGKLSAGKSAQAIATKIAEVTKTAFDQG
                     DYIFFAIDCHDQNDPWHPESKLFAAHNIKGTTGRHLYGPLAEVYSYMKQHPRVFWIDK
                     RYYSAFSGTDLDIRLRERGITQLVLTGVLSDICVLHTAIDAYHLGYQLEIVKSAVASL
                     TKESYEWSLAHFEQVLGAKLINDY"
     gene            complement(30452..31234)
                     /gene="codY"
                     /locus_tag="VHC05_000183"
     CDS             complement(30452..31234)
                     /gene="codY"
                     /locus_tag="VHC05_000183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001133183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-sensing pleiotropic transcriptional
                     regulator CodY"
                     /protein_id="HEQ5401532.1"
                     /translation="MPNLLEKTRKITSILQRSVDSLETELPYNTMASRLADIIDCNAC
                     IINGGGTLLGYAMKYKTNTDRVEEFFEAKQFPDTYVKAASRVYDTEANLSVENELTIF
                     PVESKDTYPGGLTTIAPIYGGGMRLGSLIIWRNDDEFSDDDLILVEISSTVVGIQLLN
                     LQTENLEDTIRKQTAVNMAINTLSYSEMKAVAAILGELDGNEGRLTASVIADRIGITR
                     SVIVNALRKLESAGIIESRSLGMKGTYLKVINEGIFAKLKEF"
     gene            complement(31451..32665)
                     /locus_tag="VHC05_000184"
     CDS             complement(31451..32665)
                     /locus_tag="VHC05_000184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012679061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEQ5401533.1"
                     /translation="MKIIEKSSKLEHVAYDIRGPVLDEANRMIASGEKILRLNTGNPA
                     AFGFEAPDEVIRDLIVNARLSEGYSDSKGIFSARKAIMQYCQLKGFPDVDIEDIYLGN
                     GVSELISMSLQALLDNGDEVLVPMPDYPLWTACVSLGGGKAVHYLCNEEAGWYPDIAD
                     IKSKITSRTKAIVVINPNNPTGALYPKEILEDIVALAREHQLIIFADEIYDRLVMDGK
                     EHIAIASLAPDVFCVSMNGLSKSHRIAGFRVGWMVLSGPKDHVKGYIEGLNMLANMRL
                     CSNVLAQQVVQTSLGGHQSVDALLLPGGRIFEQRNFIYEAINAIPGLSAVKPEAGLYL
                     FPKIDRQMYRIDDDEEFVLQLLKQEKVMLVHGRGFNWKDPDHFRIVYLPSVEELEDVQ
                     EKITRVLYQYRR"
     gene            32896..33348
                     /locus_tag="VHC05_000185"
     CDS             32896..33348
                     /locus_tag="VHC05_000185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015055992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="universal stress protein"
                     /protein_id="HEQ5401534.1"
                     /translation="MSLKYKRILVAIDGSYESELAFNKGVNVALRNDATLLLVHVIDT
                     RALQSVATFDTYIYEKLEQEAKDVLDDFEKQAQIAGITNTKQIIEFGNPKNLLAHDIP
                     DRENADLIMVGATGLNTFERLLIGSSSEYIMRHAKIDLLVVRDSTKTL"
     gene            complement(33470..34858)
                     /locus_tag="VHC05_000186"
     CDS             complement(33470..34858)
                     /locus_tag="VHC05_000186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEQ5401535.1"
                     /translation="MTVKAVFFDIDGTLLNDRKNIQKTTQKAIQQLKKQGIMVGLATG
                     RGPGFVQPFLENFGLDFAVTYNGQYILTRDKVLYQNQLPKSMIYKVIRYANEKKREIS
                     LGTASGLAGSRIIDMGTSPFGQVISSFVPKSWARTVEGSFKHLIRRIKPQSFRNLVTI
                     MREPIYQVVLVASQAETKKIQEKFPHIKITRSSPYSLDLISVDQSKIKGIERLGEMFG
                     FDLSEVMAFGDSDNDLEMLSGVGIGIAMGNAETVVKDGAHFTTDSNNNDGISKALAHY
                     GLIHFDIEKSFKSRDENFNKVKDFHRLMDSDTIETPRSYTISEAGYRSGFKVEEIVEF
                     LYAASKGDQQQFTQAIFDLHGAVDQAANKVQAKKHVETPLIGQVDALADLLYFTYGSF
                     VLMGVDPQPIFEAVHEANMAKIFPDGKAHFDPVTHKIQKPDYWQERHAPEVAIKKELD
                     KQLQKSLQRFDK"
     gene            34930..35895
                     /locus_tag="VHC05_000187"
     CDS             34930..35895
                     /locus_tag="VHC05_000187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017643115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparaginase"
                     /protein_id="HEQ5401536.1"
                     /translation="MKKILVLHTGGTISMQADNSGRVVPNQDNPMTKIHAAVQDIQLT
                     VSDFLNLPSPHITPHHMLSIYHHIQERTDVFDGIVITHGTDTLEETAYFLDTMALPTN
                     IPVVLTGAMRSSNEVGSDGIYNYLTALRVASSDKAKEKGVLVVMNDEIHAAKYVTKTH
                     TTNISTFQTPTHGPLGIIMKNGLLFFKTAEPRIRFDLRCISGTIPIIKAYAGMGDGSI
                     LSLLTPGSIQGLVIEALGAGNVPPLAVGEIEHLITLGIPVVLVSRCFNGMAEPVYAYE
                     GGGAMLQEAGVMFVKELNAPKARLKLLIALNAGLTGQELKDYIEG"
     gene            complement(36244..36948)
                     /locus_tag="VHC05_000188"
     CDS             complement(36244..36948)
                     /locus_tag="VHC05_000188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5401537.1"
                     /translation="MISYLKADLFRIRQERLALFSCMLLVVIAVGVAYSFRKTPNQVT
                     MIQIINIITDFVTLFFLTPARIFFSDDYNYRTINNVVVKQQNRTLIIIYKLLVSFGLS
                     LLFISLTYLLSALAFHLFTGQAYYGIVIDRMIKQLPFYIAIIALCQFLFNILRKTYQS
                     ITAYILYVLLFDKVSATLANHFFKLDISPVLMFKHLSLSLGDKHLSSTSILVAFGLTL
                     CYLLGNVFLFSKRELK"
     gene            complement(36961..37863)
                     /locus_tag="VHC05_000189"
     CDS             complement(36961..37863)
                     /locus_tag="VHC05_000189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401538.1"
                     /translation="MTQQSMLLSIEQVNKSYGKNQVLSDISFDIYKGEICGLVGQNGA
                     GKTTLMRILSGLIGKDSGQIKQLQPYRMGSIIESPTLYPNMTAHDNLYYAALQLRLTD
                     AKERIHEVLELIGLEKVSKKKKVKDYSLGMRQRLAIGLSILDFPEFLILDEPINGLDP
                     AGIKEMRQIILNLRDCYGITILISSHILSELDLVVDRYVIMHKGKVIKSMDKAELKAQ
                     VKVQIALHTSDDQLVKNRLLELGLRVETDGQMLLIKPTLSVMELIKIVLDLPVEIFDI
                     YHHQVSFEHYYLDLLGKDAASPLI"
     gene            complement(38156..40171)
                     /gene="recG"
                     /locus_tag="VHC05_000190"
     CDS             complement(38156..40171)
                     /gene="recG"
                     /locus_tag="VHC05_000190"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent DNA helicase RecG"
                     /protein_id="HEQ5401539.1"
                     /translation="MILTAPMSNLKGFGPKSAEKFQKLDIYTVEDLLLYYPFRYEDFK
                     SKSVFDLVDGEKAVITGLVVTPANVQYYGFKRNRLSFKLRQGEAVLNVSFFNQPYLAD
                     KIELGQEVAVFGKWDATKSAITGMKVLAQVEDDMQPVYRVAQGISQSTLIKAIKSAFE
                     IDAHLELKENLPATLLEKYRLMGRSQACLAMHFPKDITEYKQALRRIKFEELFYFQMN
                     LQVLKAENRSETNGLPILYSKHAMETKISSLPFILTNAQKRSLDDILSDMSSGAHMNR
                     LLQGDVGSGKTVIAGLSMYAAYTAGFQSALMVPTEILAEQHYISLQELFPDLSIAILT
                     SGMKAAVKRTVLAAIANGSVDMIVGTHALIQDSVQYHKLGLVITDEQHRFGVKQRRIF
                     REKGENPDVLMMTATPIPRTLAITAFGEMDVSVIDELPAGRKPIMTRWVKHEQLGTVL
                     EWVKGELQKDAQVYVISPLIEESEALDLKNAVALHAELSTYFEGIAKVALVHGRMKND
                     EKDAIMQDFKDKKSHILVSTTVIEVGVNVPNATIMIIMDADRFGLSQLHQLRGRVGRG
                     HKQSYAVLVANPKTDSGKKRMTIMTETTDGFVLAESDLKMRGSGEIFGTRQSGIPEFQ
                     VADIVEDYPILEEARKVSAAIVSDPNWIYEKQWQLVAKNIRKKEVYD"
     gene            complement(40546..42000)
                     /locus_tag="VHC05_000191"
     CDS             complement(40546..42000)
                     /locus_tag="VHC05_000191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401540.1"
                     /translation="MERLGGADLDYCYHNHHDTSMISAEQLVFTYHDQKNPACQVSTC
                     QIASGQFIVLCGSSGSGKSTFLKFLNGIIPDYYAGKYEGRLDVADCQAGRDSVETFSR
                     SVASVFQNPASQFFYREVQHELVFPCENQGLDAKVIMKRLWTLAEDFAFAELLNKDMF
                     GLSGGQKQRVAIATAIMQGTNIMLFDEPTANLDSAGIAAVKAYLTQLKAAGKTIIVAE
                     HRLHYLMDLADNFFYFKNGRLTDKLTTQDLLALTDEQRQDMGLRRLDLSDLKPVLAGK
                     IESQHYRPDDSLCIEHLTVRAGSKILRCIEQLSFAAGSISGITGSNGLGKSQLVYYIA
                     GILDDKKATIKFQGIPLSAKQRLSKTSIVLQEVSLQLFAESVSKEVNLGHERHPRTTE
                     VIERLSLTTLLERHPASLSGGEQQRVMIAASLLADKDILIFDEPSSGLDLLQMKALAN
                     LLMQLKTQHKVVILISHDEELLSSVCDTIYQMLP"
     gene            complement(41937..42617)
                     /locus_tag="VHC05_000192"
     CDS             complement(41937..42617)
                     /locus_tag="VHC05_000192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEQ5401541.1"
                     /translation="MRLDVRTKLLLLVLANACFFFRVDGFLEFIIVIFLLLLLSALNK
                     KKLAFKLAVVYLLMIGLSVIPLSIFPSYLDHLLSFVSIAGRLVFPSLLAGLITIKTTT
                     IYELVHGLRKWHFPEVWLLTLAVMCRFIPMIRQECCVIHRSLTIRGIILTKWSILIRP
                     KRYLEYLMVPLLLSLIRSSQELTIASLTKGLAVNKGTSECFSSHLTWKDWGVQIWITV
                     IIIITILQ"
     gene            complement(42614..43207)
                     /locus_tag="VHC05_000193"
     CDS             complement(42614..43207)
                     /locus_tag="VHC05_000193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HEQ5401542.1"
                     /translation="MKQLTIKDIMITGAFAALYFICVGLGTFINIFFDRSGNMLYAPA
                     FAALLGGTIYFLLIAKLQTFGPITLLGLMMGGFFFLSGHFFAAMFPSIIFGLIADIIA
                     SLGKYKSRFFNDLSYMVFAFVNSGPIVLMWLLKDAYVESLLARGKSMTYVNRIMYDFS
                     LGHVIWFVGIVLAGALLGSAFAHYLLKKHFIKSGLLS"
     gene            complement(43204..44874)
                     /locus_tag="VHC05_000194"
     CDS             complement(43204..44874)
                     /locus_tag="VHC05_000194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401543.1"
                     /translation="MAKPNRSTLSLVWRLLTLMKTLLPWIILAVGFAVMGFVITVSIP
                     TGIAYLGLLAIRQEVIPILALYLLIALAFLRGFVRYGEHYFGHFVAFHSLAAFRNLIF
                     KKLRALSPACLDSQDSGYLLKMIGEDIEALEVFFAHTIAPICTAILSAGLMFWYFCQS
                     SWQLALLALATYACLAIVIPIYFANILQVLLKSQNEGRKDYLSYFLESLRSVKDLLQF
                     QVLDEQFERLIKKSNHVNALDRNVAQAQFLQMALTFFWLGLMILAFSYMVFDGICHDS
                     LSFDKGLLTFIAFTASFSPFLELGRLPLGFKRAMNAARNIFDLLDENVIVDEGTKQID
                     RLRSVSFEDLSFAYPKRQELVFKDLSVTFQEKGIIGIKGESGSGKSTLVKLIMKWYNW
                     KTGDIFLNDRNSCLLNAAKLQDTIAYVPQTAQLFQQSIRENLTFGRQDISDESIWNLA
                     EACGMKDRLLACKEGLDTIIKSPSDFSAGEGQRLELMRALLKDASCYIFDEPTSNLDS
                     LNEAILLDLIKTHCQGLVFLISHRPSTLACADHLFCVKNGSLKEVNKK"
     gene            complement(44867..46630)
                     /locus_tag="VHC05_000195"
     CDS             complement(44867..46630)
                     /locus_tag="VHC05_000195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="HEQ5401544.1"
                     /translation="MMETEDTISRGKRKRLLKRLRERIAPKRYLLYVSAFLSWLQFVM
                     RMISFYLIAKTFSTFILGHTIALGRLAGLLLLLNVVGFVLAILGKQLQGIASQFARDS
                     LKQSFFEAFIDLDGQFDAHASDADILTLASQGIDSLDTYYGYYLSLSMRTKWNCTTIM
                     ILVFLIYPLAGLVFLGVLPLIPLSIVAMQKRSKQIMSHYWSSYMDVGNLFMDDLKGLN
                     TLYSYQAIERYEQEFSGKAEQFRKATMSLLGFQLQAVGYMDAVMYLGIGLSGFLAVQA
                     LATGQLSFFNFLFFLLIATEFFTPIREQGYGMHLVMMNTKMADRIFSFLDSVPARKDN
                     KSKTAINFNQIDIQNISLAYEKKTVLSGVTMTLTKGQLTAIAGVSGQGKTSLAQLLLK
                     RQSATTGHILFDGLDSDNLSQETINQQVLYVSDQSTLLNRSIYDNLRLAANLSKKEIL
                     DWIDQHGLLSFINWLPDGLDTIVGENGNLLSPGQKQQVICARALLSKRSLYIFDEATS
                     SLDAENERIIDNLITRLAKTAIVIVITHKMSRLKGANQVLFLNTGQPACLGKPCDLYR
                     DQPTYRHLVDTQARLEASIYG"
     gene            complement(46627..47463)
                     /locus_tag="VHC05_000196"
     CDS             complement(46627..47463)
                     /locus_tag="VHC05_000196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401545.1"
                     /translation="MSKNSSHIQVQNLSFAYEEKLVLDDLTFSIPKGKITTIMGANGS
                     GKSTLLQLLTKNLPLKQGQVWLEQEELATLSLKAFAKKVAVVHQYHQVVEGLLVGELV
                     AMARLARRSFFKTTTKEDEERLAWALEVTALSDYVYRDIQHLSGGEQQRVWIAMALAQ
                     DTDIIFLDEPTTYLDIKYQLDILKLITKINQELGLTIVLVLHDINQALSLSDHLIGLK
                     DGRLYAQGQPRDLLDQQFIRDVFGVELPFVERNGQQFVLTSLVNETNDIRTQRRDRNK
                     NR"
     gene            complement(47460..48482)
                     /locus_tag="VHC05_000197"
     CDS             complement(47460..48482)
                     /locus_tag="VHC05_000197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEQ5401546.1"
                     /translation="MTASDLQRDQSLLTKKRFRSGLYLVLLILSLLFLAVIALSLGGL
                     AVSYEAIVKGLFVAYDPQVALIYDLRFPRIVIALLAGAGIAVSGVLFQAVLKNPISDP
                     AIIGICSGASFMVLVSSLLLPQLLLYGPIVSFLGGGVSFLLIYGLAWKKGLNPIRLIL
                     TGIAINALFMGLSTALTSFFTSASPMVNALLAGHISQKTWADVGVLFPYTFIGLLLAL
                     LLSKTCNLLLLDDQVIRHLGIDATALRLGISLVAVLLASVATSIVGVVSFLGLIVPHM
                     SRLLVGSKHQILIPFSALLGAFVFLLADTLGRSLAYPLEISPAIIMSIVGGPYFIYLL
                     RRSDII"
     gene            complement(48484..49368)
                     /gene="isdE"
                     /locus_tag="VHC05_000198"
     CDS             complement(48484..49368)
                     /gene="isdE"
                     /locus_tag="VHC05_000198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heme ABC transporter substrate-binding protein
                     IsdE"
                     /protein_id="HEQ5401547.1"
                     /translation="MIKRCKGIGLALMAFFLVACVNQHPKTAKETEQQRIVATSVAVV
                     DICDRLNLDLVGVCDSKLYTLPKRYDAVKRVGLPMNPDIELIASLKPTWILSPNSLQE
                     DLEPKYQKLDTEYGFLNLRSVEGMYQSIDDLGNLFQRQQEAKELRQQYQDYYRAFQAK
                     RKGKKKPKVLILMGLPGSYLVATNQSYVGNLLDLAGGENVYQSDEKEFLSANPEDMLA
                     KEPDLILRTAHAIPDKVKVMFDKEFAENDIWKHFTAVKEGKVYDLDNTLFGMSAKLNY
                     PEALDTLTQLFDHVGDHS"
     gene            complement(49352..50227)
                     /locus_tag="VHC05_000199"
     CDS             complement(49352..50227)
                     /locus_tag="VHC05_000199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heme-binding protein"
                     /protein_id="HEQ5401548.1"
                     /translation="MTKVVIKQLLQVIVVFMISLSTMTGVVYADKGQIYGCIIQRNYR
                     HPISGQIEDSGGEHSFDIGQGMVEGTVYSDAMLEVSDAGKIVLTFRMSLADYSGNYQF
                     WIQPGGTGSFQAVDYNITQKGTDTNGTALDIAISLPTVNSIIRGSMFVEPMGREVVFY
                     LSASELIQKYSGNMLAQLVTETDNSQNQEVKDNQKPVDTKLGESQDESHTGAMITQNK
                     PKANSSNNKSLSDKKILPSKMGLTTSLELKKEDKFRSKKDLSIMIYYFPTFFLMLGGF
                     AVWVWKKRKKNDKTM"
     gene            complement(50424..54251)
                     /gene="shr"
                     /locus_tag="VHC05_000200"
     CDS             complement(50424..54251)
                     /gene="shr"
                     /locus_tag="VHC05_000200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heme-binding protein Shr"
                     /protein_id="HEQ5401549.1"
                     /translation="MKKISKCAFVAISALVLIQATQTVKSQEPLVQSQLVTTVALTQD
                     NRLLVEEIGPYASQSAGKEYYKHIEKVIVDNDVYEKSLEGERTFDINYQGIKINANLI
                     KDGKHELTIVNKKDGDILITFIKKGDKVTFISAQKLGTTDHQDSLKKDVLSDKPVPQN
                     KGTQKVVKSGKNTANLSLITKLSQEDGAILFPEIDRYSDNKQIKALTQQITKVTVNGT
                     VYKDLISDSVKDTNGWVSNMTGLHLGTKAFKDGENTIVISSKGFEDITITVTKKDGQI
                     HFVSAKQKQHVTAEDRQLTKLDVTTLEKAIKEADAIIAKESNKDAVKDLAEKLQVIKD
                     SYKEIKDSKLLADTHRLLKDTIESYQAGEVSINNLTEGTYTLNFKANKENSEESSMLQ
                     GAFDKRAKLVVKADGTMEISMLNTALGQFLIDFSIESKGTYPAAVRKQVGQKDINGSY
                     IRSEFTMPIDDLDKLHKGAVLVSAMGGQESDLNHYDKYTKLDMTFSKTVTKGWSGYQV
                     ETDDKEKGVGTERLEKVLVKLGKDLDGDGKLSKTELEQIRGELRLDHYELTDISLLKH
                     AKNITELHLDGNQITEIPKELFSQMKQLRFLNLRSNHLTYLDKDTFKSNAQLRELYLS
                     SNFIHSLEGGLFQSLHHLEQLDLSKNRIGRLCDNPFEGLSRLTSLGFAENSLEEIPEK
                     ALEPLTSLNFIDLSQNNLALLPKTIEKLRALSTIVASRNHITRIDNISFKNLPKLSVL
                     DLSTNEISNLPNGIFKQNNQLTKLDFFNNLLTQVEESVFPDVETLNLDVKFNQIKSVS
                     PKVRALIGQHKLTPQKHIAKLEASLDGEKIKYHQAFSLLDLYYWEQKTNSAIDKELVS
                     IEEYQQLLQEKGSDTVSLLNDMQVDWSIVIQLQKKASNGQYVTVNEKLLSNDPKDDLT
                     GEFSLKDPGTYRIRKALITKKFATQKEHIYLTSNDILVAKGPHSHQKDLVEKGLRALN
                     QKQLRDGIYYLNASMLKTDLASESMSNKAINHRVTLVVKKGVSYLEVEFRGIKVGKML
                     GYLGELSYFVDGYQRDLAGKPVGRTKKAEVVSYFTDVTGLPLADRYGKNYPKVLRMKL
                     IEQAKKDGLVPLQVFVPIMDAISKGSGLQTVFMRLDWASLTTEKAKVVKETNNPQENS
                     HLTSTDQLKGPQNRQQEKTPTSPPSAATGIANLTDLLAKKATGQSTQETSKTDDTDKA
                     EKLKQLVRDHQTSIEGKTAKDTKTKKSDKKHRSNQQSNGEESSSRYHLIAGLSSFMIV
                     ALGFIIGRKTLFK"
     gene            complement(54743..56272)
                     /locus_tag="VHC05_000201"
     CDS             complement(54743..56272)
                     /locus_tag="VHC05_000201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEQ5401550.1"
                     /translation="MNKNKLLRVAMLLSLLAPTAESMTVLAQDVMLETHKATTNETSD
                     SSSKEENNKNAAPTTSDKTDQGPLDASAETNSNSLVNADDKKRSDSSQSAVGSSDNKA
                     EAENQVDDKSTDHSKPTDHSKPTDQPKPTDQPKPSPSKVDTAPASSLSRQLPEVRTPI
                     QSLSPYVSDLDLSEIDIPSVNTYAAYVEHWSGKNAYTHHLLSRRYGIKADQIDSYLKS
                     TGIAYDSTRINGEKLLQWEKKSGLDVRAIVAIAMSESSLGTQGIATLLGANMFGYAAF
                     DLDPTQASKFNDDSAIVKMTQDTIIKNKNSNFALQDLKAAKFSRGQLNFASDGGVYFT
                     DTTGSGKRRAQIMEDLDKWIDDHGGTPAIPAELKVQSSASFASVPAGYKLSKSYDVLG
                     YQASSYAWGQCTWYVYNRAKELGYQFDPFMGNGGDWKYKVGYALSKTPKVGYAISFAP
                     GQAGADGTYGHVSIVEDVRKDGSILISESNCIGLGKISYRTFTAQQAEQLTYVIGKSK
                     N"
     gene            complement(56359..57459)
                     /locus_tag="VHC05_000202"
     CDS             complement(56359..57459)
                     /locus_tag="VHC05_000202"
                     /EC_number="5.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HEQ5401551.1"
                     /translation="MISSFHRPTVARVNLQAIKENVASVQKHIPLGVKTYAVVKADAY
                     GHGAVQVSKALLPQVDGYCVSNLDEALQLRQAGIDKEILILGVLLPNELKLAITRQVT
                     VTVASLEWLAMAKQEWPDLKGLKVHIKIDSGMGRIGLRSVTEVDNLIAGLKSMGAEVE
                     GIFTHFATADEADDTKFNQQLQFFKKLIAGLEDKPRLVHASNSATSIWHSDTIFNAVR
                     LGIVSYGLNPSGSDLSLPFPLQEALSLESSLVHVKMISAGDTVGYGATYTAKKSEYVG
                     TVPIGYADGWTRNMQGFSVLVDGQFCEIIGRVSMDQLTIRLPKAYPLGTKVTLIGSNQ
                     QKNISTTDIANYRNTINYEVLCLLSDRIPRIY"
     gene            complement(57456..57812)
                     /locus_tag="VHC05_000203"
     CDS             complement(57456..57812)
                     /locus_tag="VHC05_000203"
                     /EC_number="2.7.8.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holo-ACP synthase"
                     /protein_id="HEQ5401552.1"
                     /translation="MIVGHGIDLQEISAIEKVYQRNPRFAQKILTEQELAIFESFPYK
                     RRLSYLAGRWSGKEAFAKAIGTGIGRLTFQDIEILNDVRGCPILTKSPFKGNSFISIS
                     HSGNYVQASVILEDKK"
     gene            complement(57928..60447)
                     /gene="secA"
                     /locus_tag="VHC05_000204"
     CDS             complement(57928..60447)
                     /gene="secA"
                     /locus_tag="VHC05_000204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HEQ5401553.1"
                     /translation="MANILRKVIENDKGELRKLEKIAKKVESYADQMASLSDRDLQGK
                     TLEFKERYQKGETLEQLLPEAFAVVREAAKRVLGLFPYRVQIMGGIVLHNGDVPEMRT
                     GEGKTLTATMPVYLNAIAGEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKS
                     PAEKREAYNCDITYSTNSEVGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEAR
                     TPLIVSGAVSSETNQLYIRADMFVKTLTSVDYVIDVPTKTIGLSDSGIDKAESYFNLS
                     NLYDIENVALTHFIDNALRANYIMLLDIDYVVSEDGEILIVDQFTGRTMEGRRFSDGL
                     HQAIEAKEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIP
                     IPTNRPIARIDHTDLLYPTLESKFRAVVEDVKTRHAKGQPILVGTVAVETSDLISRKL
                     VEAGIPHEVLNAKNHFKEAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCV
                     IGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMRRFGSDRIKAFLDRMKLDE
                     EDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREIIYANRRDVITANR
                     DLGPEIKAMIKRTIDRAVDAHARSNRKDAVDAIVTFARTSLVPEESISAKELRGLKDE
                     QIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMIVDNKWTEHIDALDQLRNAVG
                     LRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQIHEQERERASQRATTAAP
                     QNIQSQQSANTDDLPKVERNEACPCGSGKKFKNCHGRKSFS"
BASE COUNT        18323 a        12909 c        10546 g        18765 t
ORIGIN      
        1 aaaaaaacag ttatcctatc ttttttacta atgaatacac ttaacttatc ttttctcttt
       61 atcttggagc aaaatttgct ataatttaat tatgactaaa aaattgattg ccattgattt
      121 ggatggaacc ttattacatc atgacaacac catctctacc tatactcaaa aaaccatcaa
      181 agctgtccaa gacaagggcc accacgtcat tatttcaaca ggccgtcctt accgcatggc
      241 actggactac tatctgcagc tcaatttaaa gaccccaatc attactttta atggggcctt
      301 gacccacatg cctgaacaaa aatgggccta tgaacataat gtcactttgg acaaaggcta
      361 cctactaagg ttactacaat atcaggatga tttccagatg gattttattg ccagtgagta
      421 tcgaaaaaat gtctacatta ccatgaccaa tccagaaagt atcgacccgc aactctttgg
      481 tgttgatgaa attactcagg acatggcatt agagattacc aaaatcactc gaaatccaaa
      541 cgccttattg atgcaaacgc gccacgaaga caagtatgcc ttagctaaaa acatgcgtgc
      601 tttcttcaaa gatgaaattg aaattgattc ttggggaggc cctctcaaca ttcttgaaat
      661 ttcgtctaag aatgtcaata aagcttacgc tctgaactat ctccttggaa tttacaatat
      721 ggataaaaag gatttaatcg cctttggtga tgaacacaat gacactgaga tgctagcttt
      781 tgctggaact ggttatgcca tgaaaaatgc tagccctgtg ctactgcctt atgctgatca
      841 gcagcttaat ttttccaacg aagaagacgg tgttgccaaa aaattggaag aacttttctt
      901 gtagtagcaa acgaaaccac tatttttcag aaaatggtgg tttttcttct gtcaacagct
      961 atcaaaaaat gaaaatcatt ttaataattt caacattttt cagcatattt ttgttttaaa
     1021 cagcttgaaa acacctttaa tatcaataat ctgcctattt aatcctaaat tctgaaaatt
     1081 ttttcatgtt ttgtactatt tttccgaaag ggcttgattt tttagtgaaa acgttttaaa
     1141 atagaaacgt tcttgaattt cgtttaagtg aaaaagaatt gccaaaattt agttttggaa
     1201 ggagattatt cttcttcatt tcaacgaaaa atattttaaa ggaggaagaa caagaatggg
     1261 tatcggtatt attattgcca gccatggtaa atttgctgaa ggtattcatc aatctggttc
     1321 tatgattttt ggtgaacaag agaaagttca agttgttact ttcatgccaa acgaaggacc
     1381 agatgatttg tatggacact tcaacaatgc tatccaacaa tttgatgctg atgatgaaat
     1441 ccttgtgcta gctgaccttt ggagtggttc tccatttaac caagctagtc gtgtggcagg
     1501 tgaaaatcct gaccgcaaaa tggcgatcat cactggtctc aacttgccta tgcttattca
     1561 agcttacact gaacgtctta tggatgctgg tgcaggtgtt gaacaagttg ctgcaaacat
     1621 cattaaggaa tctaaggacg gtatcaaagc ccttcctgaa gaccttaacc cagttgaaga
     1681 aactgctgca actgaaaaag ttgttaacgc actccaagga gctattcctg ctggaactgt
     1741 catcggagat ggtaaattaa agatcaatct tgctcgtgtt gacactcgtc ttttacacgg
     1801 tcaagttgca acagcatgga ctccagcttc taaggctgac cgtatcattg ttgcttctga
     1861 tgaggttgct caagatgacc ttcgcaaaca attgatcaaa caggctgcac ctggtggtgt
     1921 caaagctaac gttgttccaa ttagcaaatt gattgaagct tctaaagatc ctcgttttgg
     1981 taacacacac gcacttattc ttttccaaac ccctcaagat gcccttcgcg cggttgaagg
     2041 tggtgttgaa atcaacgaat tgaacgttgg ttcaatggct cactcaactg gtaaaacaat
     2101 ggttaacaac gttttatcaa tggacaaaga agacgttgct acttttgaaa aattacgcga
     2161 cctaggtgtt acattcgacg tccgtaaagt tcctaacgat tctaagaaaa acttatttga
     2221 gcttatccaa aaagctaaca ttaaataagt ttcaaacgct ataaggtttt aaaacgatga
     2281 ctagctaact tattagcaaa aagtcctcgt ttactatact ttgaaaggat tacaacatgt
     2341 cagatatttc gattatttct gcaattttgg tcgttatcat tgccttcttc gctggtcttg
     2401 aaggtatcct cgaccaattt caaatgcacc aaccacttgt tgcctgtact ttgattggac
     2461 ttgtaactgg acaccttgaa gctggtgtca tccttggtgg tacacttcaa atgcttgctc
     2521 ttggttgggc aaacatcggt gctgccgttg cccctgatgc tgcccttgcc tctgttgcag
     2581 ctgctatcat catggtcaaa agtggcgact ttactcaaaa aggaattacc tttgcttact
     2641 caacagctat cccacttgct gttgctggtc ttttccttac aatgatcgtt cgtactttgt
     2701 caactgccct tgtacacgct ggtgacaaag ctgccgctga aggtaatttc gcaggtattg
     2761 aacgcttcca ctttattgcc cttcttcttc aaggattgcg tatcgctgtc ccagcagctc
     2821 ttcttgttgc tgttcctact tcagccgtac aatctgtttt gaatgctatg ccaaactggt
     2881 tgaacgaagg tatgcaaatc ggtggtgcga tggttgttgc tgtaggttat gctatggtta
     2941 tcaacatgat ggctactcgt gaagtatggc cattcttcgc cctaggtttt gctcttgcag
     3001 ctattagcca attaaccctt atcgctatgg gtgttatcgg tgtagcaatt gccttcatct
     3061 accttaatct ttctaaaaaa ggtggtaacg gtggtaatgc agcaggttca gctgatccaa
     3121 tcggcgatat cttagaagac tactagaaag gggtaagaac aaatgactga acaaattaaa
     3181 ttaactaaat cagaccgtca acgtgtttgg tggcgttcac aattcttaca aggttcttgg
     3241 aactacgaac gtatgcaaaa catgggctgg gcttatgcac ttatccctgc tcttaaaaaa
     3301 ttgtatacgt ctcctgaaga ccgtgcagct gctcttgagc gccacatgga attctttaac
     3361 actcacccat acgttgcagc tccaatcatt ggtgtaacac ttgcccttga agaagaacgc
     3421 gcaaatggta cgccaattga tgacaaggct atccaagggg ttaaaatcgg tatgatggga
     3481 cctcttgctg gtatcggtga cccagtattc tggtttacgg ttcgtcctat ccttggggca
     3541 cttggtgctt ctttggcttc aacaggtaac atcgttggtc cacttctgtt cttctttgga
     3601 tggaacctta tccgtatggc cttcttatgg tatactcaag aatttggtta caaagctggt
     3661 tctgaaatta ctaaagacat gtcaggcggt atcctccaag acattactaa aggtgcttca
     3721 atccttggaa tgtttatcct tgcagtgctt gttcaacgtt gggtatctat caactttact
     3781 atcgaccttc ctggaaaaca attgtcagat ggtgcctatg tggtcttccc agatggcgct
     3841 gttaaaggtg ctgagttgaa aactatcctt gccaacgcta ttggcggtat gagccttgat
     3901 aaagtccaag ctcaaaccct tcaaggacaa ttggactctc ttatcccagg tttagctgga
     3961 ttactcctta cattcctttg catgtggtta ttgaagaaaa aagtttctcc aatcgcaatc
     4021 atcatcggct tgtttgcatt tggtatcctt gctcaccttg caggtattat gtaatcaacc
     4081 aatggaagtc tgagatgaac tcaggcttct tttttgtgct ttatgtcagg aaaatcccac
     4141 ttaaaatatg gtataataac tacaactacg caatgaaagg aacttaaatg gctcaatctt
     4201 taaacactag tgtcgaatac aagacaaaag ctgtctctta ccttggactg ggaggcaaag
     4261 ttggtcatat tttactcggt gacaaggccc ttgaatttta caacgataaa aatgtgaatg
     4321 attatattca aattccttgg acagctatca atcacatcgg ggctaatgtt tcaagaaaaa
     4381 aagttagccg ccactttgaa atttttacgg accaaggcaa gtttttattt gcttctggag
     4441 actctggaaa aatcttaaaa atcactcgtc aacatattgg taatgagaaa gtgattacat
     4501 taccaacctt gatgcaaacc tttattaaca aattttttcg acattaaaaa aataatgagc
     4561 agtgccgatt tatcatttca agaaaacaaa gaatagtagc tctaaattgc tatttagtgg
     4621 aaaagattcc ctcatttgag tttacttttt cttgtttttt gttataatag tcctaacgga
     4681 taagtaatac ctttttttca ttcagagagt ctgtggatgc tgtgaacaga tagggaaaat
     4741 gatatgaaat tctaccgtgt catcaataaa atagagatta agtgcacaga ttgtgaagct
     4801 ggatggaacc gcgccaaagc gctccagcat cttcataagc tgtgcttttt ctatcgtcag
     4861 agaatcacaa gatccaactg tcttacttag ccttgtttca ctgacagcta ctaataacta
     4921 tcttaaagga gcttatgtat gctagatctt aaacgtatcc gtaccgattt tgacactgtc
     4981 gctgccaaat taaaaaaccg tggtgtttct gaagacaccc tgacccatct taaagaactt
     5041 gatgaaaaac gtcgtactct attagtgcaa tcagaagaat taaaagcaga gcgtaatatt
     5101 gcttctgctg ccatcgctca agccaaacgt caaaaagaag atgccactca acaaattgct
     5161 gatatgcaaa aagtctctgc agatatcaaa actattgaca atcaactagt agctatcgac
     5221 cagcaagtta ctgacatcat cactgtttta cctaatactc ctcacgattc tgtccctgtt
     5281 ggagctgacg aagaagacaa tgtcgaaatt cgccgttggg gaacgcctcg tgactttgac
     5341 ttcgaagtta aggctcattg ggatctaggc gaagatcttg atattttaga ctgggaacgt
     5401 ggggcaaagg taactggtgc tcgtttctta ttctataaaa atcttggtgc tcgtttggag
     5461 cgtgctcttt ataacttcat gctggatgaa catatcaaag aaggttatca agaaatcatc
     5521 acaccttaca tggttaacca cgattccatg tttggtacag gacaatatcc aaaattcaaa
     5581 gaggacacct ttgaattagc agataccaac tttgtcctga ttccaactgc tgaagtgcct
     5641 ttgaccaatt attaccgtgg ggaaatccta gacggcaaag aattgccaat ttactttact
     5701 gcaatgagtc catcttttcg ttctgaagcg ggttctgcgg gtcgtgacac acgtggcctt
     5761 atccgcctac accaattcca caaagttgaa atggttaaat ttgctaaacc agaagaatct
     5821 taccaagaac tagaaaaaat gactgctaat gctgaaaata ttcttcaaaa acttggtttg
     5881 ccatatcgcg tcatttccct ttgtactgga gacatgggct tctcagctgc taaaacctat
     5941 gaccttgaag tctggattcc tgcacaaaat acctatcgtg aaatttcatc atgttcaaat
     6001 acagaagatt tccaagcacg acgtgctcaa atccgttacc gtgatgaagc tgacggcaag
     6061 gtcaaacttc ttcacaccct taatgggtca ggacttgctg tcggtcgtac cgtagcagcc
     6121 attttagaaa actaccaaaa tgaagatggt tctgttacca tccctgaagt actccgccct
     6181 tacatgggtg gcgaaaccgt catttcacct aaataataaa ctcaccccag agatcattaa
     6241 agtgatttct ggggtttact attttaaaga gccaccacat cacttgaaac tcactacatt
     6301 gcccctttaa caacactttt tttcacacta gtttatcaaa agtcttatta gtatacccat
     6361 ttccttattt acaagactag ttaaaaaccc ttttggaaag gcctccctta gcttgataaa
     6421 cacgtaggga gactccaaaa ggatgttgtt aatatttacg aaagcgttgg tagcgctcat
     6481 ctaataattg gtctaatggc ttagcttgca aactggttat ttgttcgatg aggttagctt
     6541 tgatgatgtc aacgatttca cttgaaaaat aaccatgttc tggaataata cgatctacta
     6601 tgcccatttg atacaattcg cctgcggtaa ttttcatcaa ttcagcagcc tctgtcgctc
     6661 ttgaaccatc tttccataaa atagaagcaa agccttctgg actaaggact gcatacatgg
     6721 tgttttctag catccagacc tgatcggcaa ccgctaaggc taatgcacca ccagagcctc
     6781 cttcaccaat aatgatggcg ataatgggaa ccttgagatc actcatttcc atcaaatttt
     6841 tagcaatggc ctcaccctgt cctcgttctt ccgcaccgac acctggatag gctcctgcag
     6901 tattgataaa cgtaacaacg ggtcgtccaa atttttctgc ctgtttcata aggcgcaaag
     6961 ctttacgata accttctgga ttgggctggc caaaattcct tgccaaatta tcctgtaaat
     7021 tcttaccttt ttgaatacca atgaccgtaa caggttgtcc cgccaaataa gctaagccac
     7081 ctacaatagc accatcatct gaaaaatggc gatcgccatg cagttccata aagtcatcga
     7141 aaataaggtt ggcgtaatcc aaagttgtta aacgcccttg atcacgcgct tcttttaaaa
     7201 ctcttgatac atctgtcatt ggccacctcc atgaaatgct actaagtggg caatcttgtc
     7261 tcgcaactct gttcgtttca caatagcatc cacaaaacca tggtcttgta aaaattctgc
     7321 tttttgaaaa tcatccggca aattctcacg tactgtggtt tcaataacac ggcgtccagc
     7381 aaatccaacc aaggattgag gttctgctaa aataatatcc ccttccatgg caaaactagc
     7441 tgttacccca ccagtagttg gatctgtcaa aatagtgagg taaaagaggc ctgcattaga
     7501 atgtcttttc acagctgcag agaccttggc catttgcata agactcatga tcccctcttg
     7561 catacgggcg cctcctgaag ccgtaaaaat caccaccggc aggttttctt cgatagccaa
     7621 ttcaaacaat cgggtaattt tttccccaac aacagttccc atactagcca taataaagtg
     7681 agaatccata atagcaagag caatttgttg tcctttaacc atagctttcc ctgtcaaaac
     7741 agcttcatgc agaccagttg tttccttggc tttttgtaat ttttcctgat aacctggaaa
     7801 gcgtaacggg tccttggttt caatacttgt aaataattcc tggaaagagc cttcatcaac
     7861 tgttaaggtc agccgctctt gggcagaaat cctaaaattg taagaacagg ttgggcaaat
     7921 ctttgccaat cccaaatctt tcttataaat catgtgctta caagctgggc atttcgcaaa
     7981 gagttcatct ggaacttctg ggacattatg gctgacagat cctttgaggg aattattggg
     8041 agtaatacgg atgtatttat cttttttacg aaataaagcc atattttctc ctaatcttta
     8101 ttgtaatgtg gcaggaacgt ttccatcaag aaagaggtat cataatctcc tgcaatcact
     8161 cgcttatctg aaatcaaatc gagctggaag tctgtattgg tgataatgcc ttcaatttcc
     8221 aattcaacta aggcacgttg cattttcatc aaagcgtcaa atcgattgct tccatgaacg
     8281 atgattttag caatcatact gtcataataa ggaggaatgg catagccatt gtaaactgct
     8341 gaatcaactc gtagtcctac accaccactt ggcatataca agtctgtaat ctttcctgga
     8401 ctcggtgcaa agttaaaagc agtattttca gcattgatac gacattcaat agcatgtccc
     8461 gtgatagtga tgtcttcttg attaatcgcc aaaggctgac ctgctgcaat tttgatttgc
     8521 tctttgacaa tatccactcc tgtcacaaat tcggtgacag gatgctcaac ttggatacgg
     8581 gtattcattt ccatgaaata gaatttctcg ctgtcttcgt ccaacaaaaa ctcaatggtt
     8641 cccgcatttt cataggctac agcttcagct gctctaaccg ctgcttgccc catttcgtgt
     8701 ctgagggtat tgccaatagc aatggatgga ctttcttcca agactttttg attattccgt
     8761 tgcaaggagc aatcccgttc tcccaagtga atgatgttac cgtaagcgtc tcctaaaatt
     8821 tgcacctcaa tatgtctagc tgggtaaatt actttttcca aatacatggc gccatttccg
     8881 aaagctccca aagcttcttg actggcagca ttgaaagccg cctccaaatc tgcttctgtc
     8941 tccactttac gaatcccttt acctccacca cctgccgatg cttttagcat gacaggataa
     9001 ccaatcttat tggcaatagc taaggcttct tgagcgttat aaacttcacc atctgaccct
     9061 ggaataacgg gcactcctgc cttaattatt tcagaacgag cattgatttt atcacccatt
     9121 ttatccataa ccgatgcgga tggaccgata aatttaatat tcatctcttc acacatggtc
     9181 gcaaactttg agttttcact taaaaagcca aaccctgggt gaatcgcttg ggctcctgtc
     9241 acaatagctg ctgacaagac ggaattcata ttaagatagg attccttgga acgggcagga
     9301 ccaatacaga tagcctcatc cgccaatatc gtgtgcagag cttccttatc cgcttccgaa
     9361 taaactgcaa ctgtggaaat ccctaattct cgtgcagcac gaatgatacg cactgcaatt
     9421 tcaccacgat tagcaattaa gattttttta aacataaggg tttcttcctc cgcagaacaa
     9481 tcattctcat tgcccacagg caaaggttaa tgttccactt gctgctagct tgccatcaac
     9541 ttctgccctg gcttcaacga cagcaatggt accgcgacgc ttgataaagg ttgctgtcat
     9601 cacaagttga tcaccaggga cgacttgttt tttgaacttc actttatcca ttccagcgta
     9661 aaagaccaac ttgcctttat tttcttcttt tgacaattct aagacaccag ctgtttgagc
     9721 caaagcttcc ataatcagaa cacctggcat cacaggatag tgaggaaaat gcccgttaaa
     9781 gaaaggttca ttaatagtca catttttaat ggcaacgata tggtcgtctg acacttctaa
     9841 cacacgatca accaataaca ttgggtagcg atgaggcaaa gctgcttgaa tttctctaat
     9901 atccatcatt tgatccgcac caatccttgt ccaaattcaa tgacatcttc atttgatacc
     9961 aaaatttctg taatcacacc atcacatggc gctggcactt cgttcatcac cttcatggct
    10021 tcgataatca caagggtttg tccttttttt acagtatctc cgactgccac aaatggtggc
    10081 ttgtcagggc tagctgcaag ataggctaca ccgactaaag gactttcaac aatatcacct
    10141 tctgctacaa aagattctgc ttgtggttgc tcctctacag gaacatcctt aactgatgct
    10201 ggactggacg cttccgaagc agttggattc ggaacaagtt gtacctgtgg tacaggcaca
    10261 gcatgttctt gatttgatgt cgatgcattg aggtgttgtt cgtttttact aaagattagc
    10321 tcaccttcat ttgttttgaa taaaaattca cgtaggcttg aggtatcaaa ctgagccatc
    10381 aaatctttga tttcttgaat attcaaccta ctcctcccaa catttgaaag ctaatacagc
    10441 attatgacca ccaaatccaa aagtatttga aatggcatag ttgatagctg tttcttttcc
    10501 ttctccaaag atgacatttg cttcgatatc ctctgataaa gcttgtgtcc cagccgtcat
    10561 cggaacatag ttatgacgca tagcctcgat agtggcaata gcttcaatag cgcctgctgc
    10621 tccaagaagg tgacccgtaa acgattttgt tgaagacacc ggaacatcct taccaagaac
    10681 ggctacaatt gcttgacttt ctcctttttc attagctggg gttgaagttc cgtgcgcatt
    10741 gacataatta atagcactgg cttcaatacc agcttcttgt aaggctaagt ggatggcttt
    10801 acgagctcct aatccctcag gatttggaga tgtcatatgg taggcatcgc aggtatttcc
    10861 ataacccaca atttctgcta agattgtcgc ctcgcgttct tgcgcatgtt ctaggctttc
    10921 taaaacaagc attcctgatc cttctcccat gataaaacca ttgcggtctt tatcaaatgg
    10981 aatagagctt ctgcttggat cttcagttgt tgagagagct gttaaacttt ggaagccagc
    11041 aatggcaaac ttggttatgg ccgcctctga cccaccaact atcatcacat cttgagtccc
    11101 aaatttaatg gcacgaaagg catccccaat cgcatcattt gaagaagcgc aagcagtatt
    11161 aattgattta catactcctt gagcttttaa agacatggcg acatttcctg cagccatatt
    11221 tggtagcgct tttggcaacg tcattggctt cacacgtttt ggcccttttt catgtaagcg
    11281 aatcacctgc tcttcaatct ccgcaattcc accaatacct gaagcgacaa taacgccaaa
    11341 tcgatcggaa tcaatcatct caatatttaa atcagcatga ttaatagcct ctttcgctgc
    11401 gtaaagagca taaagagaat atctatcgaa acggttcaaa tcttttttca caaagtattt
    11461 gtcaaatgga aaatcctgaa tttcagcagc attcttgacc gcataatcag tcgtgtcaaa
    11521 tttagtaata gggccaatac caatttggcc agctttcaga ttgttccaaa acgtttcagg
    11581 atcatgcccg attggagatg ttagaccata acctgttacc actactcttt taaatgtcat
    11641 ttcactacgt ctccttattg cattgtcata ccgccatcaa tagcgataac ttgtcccgta
    11701 atataatctt gttccaccaa gaagcttgct aagtgagcaa cttcttgagc ttttccaata
    11761 cgtttcattg ggatttgact taagatttgc tcttgcattt tttcaggaag gacacctgtc
    11821 atgtcggact cgataaatcc tggagcaata gcattcacgc aaatgttacg agcagcaact
    11881 tcacgggcaa cagacttggt aaaaccaatc attcctgcct tagaagcggc atagtttgct
    11941 tgcccaatat tgcctgttaa accaaccaca ctagagacat taataattgc tccttggcgg
    12001 gccttgatca ttggttttaa cactgattga gtcatgttaa aagcaccggt caaattgatt
    12061 ttcaagacgc gctcaaaatc ctcttccgtc attttaagca tcaatttatc attagtaatg
    12121 ccagcattgt taactaaaac atcaatcgaa cctaaacttt cgatagcttc attgaccata
    12181 cgtttagctt ctgatgcttc tgaaacatcc ccagagatgg taacaactgt aacaccgtag
    12241 tcagtaaaac tagcaacaag ctcctcagag atagcagagc gaccatttaa gacaatatta
    12301 gctcctaaac tggcgaattg atgagccatt gctaaaccga tacctctcgt tgagcctgtg
    12361 ataaatatat tttttccttt aatttccatg aatgtcctct ctatctaaaa ataaacgtaa
    12421 gcttaccatg ttttcaacac tagtacatag taaattttta tcaattttct tcacaaaacc
    12481 tgtcaaaacc ttacctggtc ctacctcaat gaattgtgtt atgccacttt ctactaaagt
    12541 cgcaacactg tcataaaaac gaacaggctc catgacttga cgggctaata gttctgggat
    12601 acggtctttt tccataatat tagcttcggt attaccaacc aaaggaatct tgaagtcact
    12661 gaagttgtat ctttccaact ctttagccaa caagcggcta gctggttcta acaaagcagt
    12721 gtggaaagga cctgacacgt ttaaagggat taaacgctta actccccttt cctttaaaag
    12781 ttcaactgcc acgttcacag catctgtctg accaccaatt acaatttgac taggagtatt
    12841 atagtttgct ggagcaacca ctccatgttt agcagctatt tgacagactt cttcgatgac
    12901 ttgcacgtct gtattcataa cggcaaccat ctttccagat ccttgtggtg ctgcttcctc
    12961 catcaagcgc cctctcttag ctactaagga tagggtatct tcaaaagaga gtgcccctga
    13021 tgctaccaaa gctgagtatt ctcctaagga aagaccagct accatatccg gtttaacgtg
    13081 atgtaagccc aaaacacggt aaatagcaat tgatgatgtc aaaatagctg gttgcgtata
    13141 gctagtttga ttaagtttta actcgtcact atcaatcaaa cggcgcaaat cgtatcccaa
    13201 tacttgacta gcttgatcaa aggtttttct tacaatagca aagttatcat aaaaatccct
    13261 tgccatccct aatttttggg caccttgacc ggcaaataaa aaggctgtct ttgtcattat
    13321 cattatcctt catgtgttta tctacttttc tattgaaaca gattgccagc gcttagcttc
    13381 attttgaata acacgagctg caccataata aatatctttt aaaatcgttt cacagctttc
    13441 ttcttttctc acaagccctg caatttggcc agccataaca gatccattga ctacatcgcc
    13501 ttcaataaca gcatgtcgaa gcgatcctgc tcccatttct tcaatatcag tagctgtttt
    13561 ttgaccaatt aaaaatgctt tttctgcttt agcgtaagct gaggtcaatt tatttttaat
    13621 agaacggaca gggtggccca caacctgcgc agaaatcacc gtatcaatat cttttgctgc
    13681 taagatttta tctttaaaat tttggtgagc attggattct ttagcaacaa caaagcgagt
    13741 tccaatttga acagcctctg ctcctaacat aaatgctgct gctgcaccat gaccatcagc
    13801 tataccacct gccgcaatga caggaatcga aaccgcttca acaacttgtc ttactaaaga
    13861 catagtcgtt aacttgccaa tatgtcctcc agcttccata ccctcagcaa taacagcatc
    13921 taccccaagc ttttccatac gtttggctag cgcaacgctt gggacaacag gaacaacgat
    13981 tatacccgcc tggtgcagtc tttccatata ctttcctgga tttcctgcgc ctgttgttac
    14041 tactttaaca ccttcttcaa tgaccaaatc aacgatatca tcagcaaatg gagataaaag
    14101 catgatatta accccaaaag gtctatcagt aatagcttta acacggtcaa tgttggcttt
    14161 aacgacttct ttgggagcat tgccaccacc gatgatacct agcccaccag cattggacac
    14221 tgctcctgct aaatcaccat cagcaaccca ggccatacct ccttgaaaaa tgggataatc
    14281 aatattaagt aattctgtaa tacgtgtttt cataataact ttctataaaa aataaggaga
    14341 ataatttgat aatcaaacta ttatagtaag aagaaagagc gagctagatc ctaaaaagag
    14401 tctaatccca ccctaatggt ttgattaata cttattgttt ttttagtgat gaacatgaac
    14461 ataacagcag taagctttgc atagacttct gatgttactt gtcactttta tccttatttt
    14521 gacttttcct caacgtaagc aacaaggtca ccaacagtat ttaatccttc ttctgtttca
    14581 atttgaatat caaaagcatc ttcaatttct gaaataactt ggaaaacatc aagtgaatct
    14641 gcatctaaat catcaaatgt agtttctagt gttacttctt ctgtctcctt accaagttct
    14701 tcaacaataa tttcttgtac tttttcaaat actgccatgt ttatttctcc ttaaaaaata
    14761 taaatttgtt tttataaatg tgctaggcac atgaataact agattttaac aattagactt
    14821 ccccatgtca aacctccacc aaaaccggaa agtaagattt tttgggtacc atctaaccta
    14881 atctgtccct tttgaacagc ctctgacaag aggattggga tactagcagc actagtatta
    14941 ccataacgca tcatgttttc aaggaatttt tcccgaggaa catcaatctt gcgtgctatt
    15001 ttatcaagta tacgacgatt agcttgatgc aataaacaat agtctatgtc atcttttgta
    15061 atatctgatt gcgccattag tgtgaggatg ctttttgaca catccctaat cgcaaaatca
    15121 aatatggcac gtccatccat ctgaatagtc gctatggctt ttttgccaat tgagtaagga
    15181 gatgaaagac tagtttctcc tgaaatcaaa ctctgacatc tcgcaccatc tgtgtgtaat
    15241 gtttccgcta aaacatgctt atctttactg gcttccagta gcacgccacc agctccgtct
    15301 ccaaaaagaa cggctgtcgc tcgatcctgc cagtttacta acttagataa agtctctgca
    15361 cctattacca ttccgttttg gtaggcacct gatgcaataa gcttatctgc catagccaag
    15421 gcaaagacaa agccactaca agcagcagtc atatcaaaag caaaagcact tgtagccgca
    15481 atagctgctt gaactttcgc agctgttgat ggcatagtgg catcagggct gatagttgca
    15541 acaataataa aatcaatagc atcagctttt aacccagact gagttaaaag ctgatcagca
    15601 acctgaatag ctaggtcact agtcatttca tctctagaaa tatggcgttc tgctattcct
    15661 gttcgagaaa agatccactc atgactagtg tccattatgt tagctaaatc attattagtc
    15721 actaactgct gtggaacata gtgggctacc tgactgattt tagaaaaaat catttaaacc
    15781 aaatcctcca aaaattgatg tagattccct agtccacgca ccaatgcctg catctcttca
    15841 tcactcatat cagcaatgac atgtccaacc atatttttat ggaactttgc atggaggcgg
    15901 tccaaaagtc gacccctttt tgttaatgac aggtaaacaa ctcgcctatc tgagcgtgat
    15961 cgcgttcttg cgatataacc ttttgcttct aatttattta agctagtggt tactgtccct
    16021 aacgttacca ttaattctct ggcgatatca cttggagtca cctgatcata tttgccgata
    16081 atttcaatag tgtgcatctc ttttaaagag acatcattaa attgactggt ttttaaactc
    16141 atctcttcaa ttaccaaaat acggttgaag atatcaacca agtagtgatt gattttgtca
    16201 tattccaagc aaatacctcc taacaataaa actttgacag tcaaattata tcagagttaa
    16261 aagcactttg caagcatgag tctacttacc ttgaaaattt ggtcggcgcc tttctccaaa
    16321 agctatgaca ccttctttaa aatcttcctt gaaagctagc tcctcttgaa tagcaagctc
    16381 tgccttagca taatcttccc atcctgtgaa aaagctttgc cagaccaatg atttcattcc
    16441 agcataagaa tttgaagagc cacgtctcaa tcgctttaaa agttgaagac aaactttgtc
    16501 tagtttatca gattctgccg tacggtagac aaacccataa tcgacacctt tatcagcagt
    16561 aattccttca cctgtcatca caagatgagt tgcacgatta agtcctactg cacgagtcaa
    16621 tagaaataaa ccaccggcat ccggtgctag tccaacattt acaaaagctt ggataaattt
    16681 tgtttgagta ctagcgatac aaaagtcaac agctaaagct atattaaaag ccgctccagc
    16741 tacagctcca tcggcgcaaa ggatgactgg ttttggcaaa tgcttgattg caaaagaaat
    16801 ttcttgtacc agttcagcaa tcttgactag cgactgcaca ttatcttttg caacagcttc
    16861 ttgcatttca actaggtcac caccaactga aaatactttt ccaacggctt taattagtaa
    16921 aaaacgcaca gatgtatcgc gtttaacttc tgctaatgct accagaatct cttgacaaat
    16981 tggaatatta aaaccgtttg aaacctctgg acggtttaaa gtcaatgtcg caagatcatc
    17041 tacaacatca aagatgatgt gtttaaactg cataacaatc ctcttttctg ataatttatt
    17101 tgactaagaa attatttctc tttaaaatca tttgataatc aaatcaatta cctaattatg
    17161 atatactaaa taaaccattt tgacaagaga aaaaaacgat atctataaaa gaaaacgttt
    17221 tctctaactg ttttgaaata aaaaaacgta taacttcggg aaaattatcc tgagattata
    17281 cgtttgacat ctttaaatat cctctaaggc atctttcact ttatcaaaaa aacctttttt
    17341 ctttggatgt aacatttttt caccactcgc ttctgcaaat gcttgcaagg cttccctttg
    17401 agcgtcattg agtttggttg gggtcacaat attaacggta acatgttgat ccccttgacc
    17461 tccaccacgg agttttggtg ctcctttgcc tttgaggcgg aaggttttac ctgtttgtgt
    17521 cccagcaggg atagccatct caacatcgcc atgaaccgtt ggaatttcaa cagtatctcc
    17581 taaggctgct tgagtaaaag aaatatctaa gctgtagtaa atagtggaac cattgcgttc
    17641 aaattgctta cttggtaaga cattcaaaat aacaaataaa tcaccataag gtccgccatt
    17701 aaagccagct tctccttgac cttgtaaacg gatttgctga ccagtctcta caccagctgg
    17761 aatcttaaca gacactttat gagcttgctt ttcatgacca gtaccgtgac aggtttgaca
    17821 gggttcttta atttccttac cactaccatg acaaatatcg caggtgactt gtcgacgcat
    17881 cataccaagt ggtgtttggg tgtcaattgt cattacacct gaaccatggc acttacgaca
    17941 agttactgga gcggtaccag gttttgcacc tgagcctaaa caagtgccgc aggttgcttc
    18001 gcgattatag ctaacttctt tttcaacacc aaatacagcc tcttcaaaag ataaattaac
    18061 acgatattgc aaatcgtcac cttgacgagg ggcatttggg tttcggcttc caccgccacc
    18121 aaagaagctt gagaagatat cttcaaaacc accaaagcca cctccgtcaa aaccaccaaa
    18181 gccgcctgct ccgccaccaa agccgccttg agcacctgca gcgccgtatt gatcataagc
    18241 agcacgcttt tgtgaatcac ttaaggtttc gtaagcttct tgaacatcct tatacttttg
    18301 ctccgctcca gcttctttat tgatatctgg atgatatttc ttagacattt ttcgataagc
    18361 ttttttgata tcgtcctgag aagcgtcctt agaaaccccc agacgatcgt aatattctgt
    18421 attgttcata atgtaagata ccaagccgta aaacgactca atgaaaaata ggaaatccga
    18481 caaagatact ctcgtatcta ggaggtattt ctcttttttc gcagagtcgt aggcgtgttc
    18541 aaatccgcaa aagagtcttt acacgcttta gcctgtgttc gaataatcga acttgtattc
    18601 ctttcttaaa atattttgac gtcagcattt ttacatttta tttagccaaa aacagaggtt
    18661 tggtacaacc tctgaattcg gatattaatg ttactagata actaaatcat tacttttctg
    18721 taaattcgcc atctacaaca tcatcattat ttgctgaatc attagcttgt gcaccttctg
    18781 caccttgtgc tgcttgttga gctgctgcag cttgctcgta cattttaaca gccaaagctt
    18841 gcgctttttc atttaatgct tcaagtttag ctttcatgtc gtcaaggttg ccagattctt
    18901 gcgcagcttt taactcgtca agagctgatt gcgctgcatc acgttctgta tcaaagcctt
    18961 taccttcagt ttctttgatt gttttttcag tagcaaagat agcttggtca acttcgtttt
    19021 taaggtcaac ttcttcttta cgtttcgcat cggcttcggc attagcttca gcatctttca
    19081 tcatgcgatc aatttcttct tcagaaagtc cgtcgtttga tttgataacg atgtgttgtt
    19141 ccttttgcgt accaaggtcc ttagctttta cagaaacaat accgttttta tcgatatcaa
    19201 atgttacttc aatttgtggg attccacgag gtgcagctgg gatatcagtc aattggaagc
    19261 gaccaagagt cttgttatct gctgccattg ggcgttcacc ttgaagaacg tggatatcaa
    19321 cggctggttg gttgtctgct gctgttgaga agacttgtga tttagatgtt gggatagttg
    19381 tattgcggtc gatcaattta gtgaagacac cacccattgt ttcaatacca agtgacaatg
    19441 gtgttacgtc aagaaggaca acgtctttca catccccagt gataacacca ccttggatag
    19501 cagcacccat agcaaccact tcatcagggt ttacagattt atttggttct ttaccagttt
    19561 cagcttttac agcttcgaca actgctggga tacgagttga tccaccaaca aggataactt
    19621 catcaatttc tgacaatgac aatcctgcat ctgaaagagc ttgacgaact ggagttttcg
    19681 tacgttcaac aaggtcacga gtgagatcgt caaatttagc acgagataag ctcatctcca
    19741 agtgaagagg accagcagaa ccagcagtga tgaacggtaa tgaaatttga gtttgagtta
    19801 cacctgacaa atctttttta gctttttcag ctgcatcttt caagcgttga agagccattt
    19861 tgtcttgaga aagatcaata ccattttctt tcttaaattc agccaccaag aaatcaataa
    19921 ttttctggtc aaagtcgtca ccaccaagtt tgttatcacc tgctgttgca agaacgtcga
    19981 agacaccatc acctaattca aggattgata cgtcaaatgt accaccacca aggtcaaaaa
    20041 ctaagatttt ttcatccttg tcagtcttgt ccataccata agcaagtgcg gctgctgttg
    20101 gttcgttaac gatacgttct acttcaagac ctgcaatttt accagcgtct ttagttgcct
    20161 gacgttgtgc atcgttgaag taagctggaa cagtaataac tgctttttct actttttctc
    20221 caagatagtc ttcagcataa cctttaaggt attgaagaat cattgctgaa atttcttgag
    20281 gagtatattc tttaccattt gcagaaactt tttcagaagt tcccatttta gatttaatag
    20341 agattactgt ttctgggttt gtcactgctt gacgttttgc agcatcaccc acgataattt
    20401 caccattttt gaatgatact actgaaggag ttgtacgatt gccttctggg ttagcaatga
    20461 tttttgattc agtcccttca agaactgcta ctgctgagtt tgttgtacct aagtcaatac
    20521 caataatttt agacatgtta atacctctta ttttataata ctttattact ttttatttca
    20581 atttatctta gtaagcactc gaattatttt acttccaatt ctaagcaatc actatagttt
    20641 aatcagcaag cgaaataact tctaacttgc tatctagttt actgtcatta cggacaaaaa
    20701 cgaaaactca tttaccttag ttatagacaa ctaccatcgc tggtcttagc agacgctcgt
    20761 gcaatttata tcccttttga aagacttctg caatgctatc ggctggatgt tcatcatcgg
    20821 ctgggagggt ctgaactgcc atatgaaagt tgtggtcaaa tgagtcaact tctacttctt
    20881 ctacgccttc ttcctttagt gcttgaataa ggctatcacg agtcatttct aaaccttttt
    20941 taacatcatc tgtcaaccct tcaacagcca aggcacgttc tagattgtca agcgatggta
    21001 agattgcttt tgccagatcc tgagaacgat agcgttgaag ttgttgacgt tcttcactag
    21061 agcgacgctg tatattctgc atttctgcat gagctcgcaa gtatttattt tcaaactcat
    21121 cagcacgttc gtttgcaagt tctaactctg atttttcagg agtttcttca ataacttcct
    21181 caactgtctc ttcagtttca gtggcttcca cttcttcttg taaatcgtct tttttaattt
    21241 cttctgacac tgagtgcctc cttttaaata acttattgaa tactgccatt atcagtggac
    21301 ttcataatgg ttagaattta ggtatcgata ataatcacct aatttagcag ccaatacctt
    21361 tccaataatg tttaccaaac taacagacct acgataatcc atatcaatag gaccaatcaa
    21421 actcaggagt ccaaacccac ggtaaggaat caaaaatttg tgagtcaaaa ctgacacatc
    21481 tgcaagtgcg gcttcttgac tatctgccac ttggacagaa gccatctcac cttctttcag
    21541 actttgcctc aaagaaattg ctacttgctg ttcattatcc aaaaactgat acgttgatag
    21601 atctgaatac gttaaagaat ttaccttacc agcaacaaat accgtttcca aaaacagctc
    21661 tgaaaaaaca taatcaaata gttgtaaaac attatccgta gtcacaaaat acttttgaac
    21721 gatctgagga atttctgtcc tcaacttata atgaatatct atgacactac tatccagcaa
    21781 gcgctcctct acgatagctt taaatgctat caagtcacgt gtcaaaaagt ttcttggaat
    21841 agcaaactgc actgtcactg gcttagattc atctaaagtc atgactgcta gagcatcatg
    21901 gttgctaagc tgaacaacat caaaccctgt taaacgttga cgagctggct ccacatctaa
    21961 aataacggat gtatagcccg tcatctccgc taaaatgtga ctagcttttt gaagcatgtc
    22021 ttctaatttg aatgcttcaa aatcaaaagt ttttatgaca tgataaatat cttgctcatc
    22081 aatactatct agcctgaggg agtgctctac aaaatactta aagccagctg gacttggcat
    22141 ccgtccacta gaagtgtgcg ctttttccaa caatcccaac ttctctagtt ttgccatatc
    22201 attacgaata gtggcgctac tagaatcaat cgttctctgt aaagctttag accctactgg
    22261 ttcatgagtt tgtgtaaata gctcaacgat taaattcaaa atatcatttt gacgttgtgt
    22321 aatcacaaac caaccactcc ctttcgttta gcactctatt tagtagactg ctaatttata
    22381 attctattat actctttatg ggagacatgt caagaaaaaa actcaaaaaa attagcactc
    22441 ttttataaag agtgctaatt tcagtcatag tttgttaaat cgttactttc aatggcctga
    22501 atcagtcgcc tagcataggt tttatcagta taatgcaaat acttttgtaa acttttagct
    22561 ggtgctttat accctttttc tgtagcaaga ttacgataca aacgcttatc gacttctttt
    22621 ccctgccgaa gcattcgtaa ataatctcta attgcactag cgtcatcttt ataaatagca
    22681 tatctcacgt tttggttggt ttgtttaggg gactttaggg taatggccgc ttgtcctgga
    22741 gttgctttct tgctaaaaag attatgatac ttagacgcta gtaatgtttt tccatcatgg
    22801 gtttccaaaa gaatttgagc aatcaaaata gatggtctaa tgccataata ttttgccgat
    22861 ggtttaactt ctttacccat ttttgtaata aattgttttt ggctgtagtt cacccttact
    22921 tctttatctg cactagctat cctttggcta ctcagtaagg gacaaacaat cagcaataaa
    22981 aagcaagcta gaagcgttaa aaaatacgga aactttagtc gttttctcat cgtttctcct
    23041 ttaaagcagc aatgtactct tccaacgtta ggttgtgctg agccatataa cgagcagacg
    23101 ccttgcctac atagcggtaa tgccaatcct cataatcaac ccctgtacta gtcttttttc
    23161 cttctggaaa gcgcaagaca aacccataat caggtgcaat tttttgaact gctttagata
    23221 ccgatgggtc actggcattt aaagtatcta cagtgctcat gtcaatagca agaccagtgt
    23281 gatgttcact agcccctggc ggctgtaaat aggtttgcac caaagcctcc gcagcttctt
    23341 gtgtcaatgt tggatcgtta gccatctctt ttttaatata agattggtaa agctctgctt
    23401 ggtaagctac ggagcgatag cctgaaataa ggtgctcttg tgggtcaata gcctgagctg
    23461 ccgctaaaaa atcagcagta gcctgttcaa tacgcttgtc caccgacacc ccattcacat
    23521 caaccaattc tgggctcaat tcctcagtca tatggtcccg attcactaaa atcaattccc
    23581 aatcttttgg agagacttta ggaagccctg tggactcttt gctatttttg accacttttt
    23641 gactgcttgc ctgttgactt gaaggcgtct tggtggcctg cttctctggc ttaataaaga
    23701 ggtaaatacc tccgacaaag agcaggacaa ccagtgtttg caataataat ttaaaatgat
    23761 tatgcttcat ctgacattgc ttctattatt tcacggccac ggtagcgata actcatatct
    23821 ccaatggttt tgatggtaaa ttgcccatca tcaaattcaa caactgtaac gctcccatta
    23881 tcaatatact gtttgtctcg atctggatca atcaaccaca gaaacgttcc aattgtcata
    23941 ccatggctaa ccacaagagc atttccgccg ccagcatttt gaatagacaa ggcaatagct
    24001 tcaaacccct cccaaatgcg cttacgaaga acttcccatg gttctgccca attagcggta
    24061 tctacttcca agatgctttc tgccagttca gaatagggaa catcacgtag gttatcacga
    24121 ttttcaaagg cttttgttct tggaaggaca cctagaaata attctgaatc ataagtccct
    24181 tctagactcc caaaacacca ctcacgaata cgattatctt tagtataagg caaaaattcg
    24241 ttttctgatt ctcttaaaat aatttctatt gtctgcatgg ttcgacctga atcacttgaa
    24301 aacgcagcct taaatggtat agttgcatct tttaaaccta agccaagttc tcgaatacct
    24361 tcttctcctt tttttgtaag aggtgtgtca ctccaaccct gagcgcgacc aatggtatta
    24421 aacatcgttt ttccatgtct ggcaatatac aaccttgttt ttgtcatttc aacctcctaa
    24481 actgtcttat taattattat agcatttaaa gaaaacactt gcaaaacact tcctgatagc
    24541 tatttgagat caaatagacc actgacttat tgtctatttt attaaaaata atgctattgc
    24601 tacaattcaa atcatcacat aaatttccaa acgattacat ttgtgcgttt cgctcaaata
    24661 tatataacaa cagacccaca ctacaactaa actgacgtta caaaatgatg tcaaaacagt
    24721 aacaaaatct aactatttgt caagaaaatg atattaaatt ttcacacaac tatcttataa
    24781 tgaggatgca accaataaaa agataagaca ttttatgttg caaaaaaggc tgcttggaaa
    24841 cttccatgca gccttttttt aatacctttt tccaaaaata gctgaaacaa gtacaattac
    24901 aattgccgct cccaaaatgg acgggaaaat agccatacct gccaactgaa ttccccaatc
    24961 cccaaaaagc ctttgcccaa cagctgaccc tatgagacct gcgataatat tagtaaaaca
    25021 acccatggac tggctttttt cagtcatttt acctgctatc atgccgataa aggcacctac
    25081 aattaaagac catatcatcg ttaacacctc ctttcttgta aaatcctttt agaagaactg
    25141 ctatccatta aatgttctta actttagttg attcctttac cttcttcttt agtaaatgtt
    25201 tccgtgcctg agtaaaatag aaaaaacaat tccttctatt aaggtagata gaccgagaac
    25261 gactagaagt cttcacacac taaataactt aacaaacttt atcacacagc taatcgctaa
    25321 taatagtgta gacaaacgtg atggttcatt aaatacacgt cagaaactcc tgaaggttct
    25381 aaagcaatac ctgtcagtct tattttagca tagatgatgg tctttttata gacggtcact
    25441 aacatgacat acaaaaaggc agcctgtgaa agaccgaccg cctttttttc agagacaaaa
    25501 tactttaact tattgctatc agcaactatc aatctcgcaa tttttgcaat tcttgtgcca
    25561 ataattgttg agcgacttgt ggattagctt gacctttggt tgccttcatc aagaagcctg
    25621 tgaaagcctt atcagcatta cgtttgcctg atttgaaatc agccactgca gcttcattat
    25681 cagcaaagac ttggtgaata attggtacca aaacagcggg atcagaaatc tgaacaagtc
    25741 ctgccttttc gacgtaggcg cgagctgagc caccgttttt agccaaatgc acaaagacct
    25801 tcttagccat tttagaagag attgtaccat cagcaataat agcaatcatt tccactaagt
    25861 tgtcaggcgt caatctaatt tcttcaatgg ttttgccttc tgcatttaag aattgggcaa
    25921 cttccccttg caaccagtta gagacttgct tggcatcgcc accaagactt actgcagttt
    25981 caaagaaatc tgacaaggct ttggtagctg ttagttggct agcatcataa gctgagaggc
    26041 caagttcctc ttcgtattta gcacgacgct gagctgggaa ttgaggtaat tgagcacgca
    26101 tctcgtcaat ccaagcatca tcaatctcat ataatggcag gtctggttct gggaaataac
    26161 gatagtccgc tgccccttct ttgacccgca tcaaaatagt ccccttattc gcttcgtcat
    26221 agcggcgcgt ttcttggcgt atcacaccac ctgaacgcaa gagtttggct tgacgttcca
    26281 cctcaaattc aagcccttta cggacatttg agaaggagtt caagtttttc aattcggtct
    26341 ttgttccaaa ttgttcttgc ccgtaaggac gaagggaaat attggcatcc acccgcatag
    26401 agccttcttc catcttgacg tcagaaatgc ctgtgtactg gatgatttct ttcagagctg
    26461 tcaaataagc ataggcttct tcaggagaac gcatgtcggc ttctgacaca atctcaatca
    26521 aaggaactcc ttggcggtta aggtccacat aagaataacc atctgtgccg tgagtgtttt
    26581 taccagcatc ttcttccaag tgtgcgcgtt caatacgaat tttcttggtt gaaccgtctt
    26641 ctagtttgat atcaatccag ccgttgtagc caatcggctc atcaaactgt gaaatttggt
    26701 aagctttagg attgtctggg tagaaataat ttttgcggtc gaaatgcatc tctttatgga
    26761 tgtccatatt gagggcaagc gcagcttgta tgcccgcatc aatcacccct ttgttcatga
    26821 ctggtaagac ccctgggaaa gaccaatcaa tcacattcgt gttggcattt gggtcctcac
    26881 caaagtgagc tgacgaaggt gagaaaattt tggaattggt atttaattcc acatggactt
    26941 caagcccaat aatggtttca aaattcatta cttgtcacct ccaaaaataa tcggttgttg
    27001 cttgtgataa tctgtcaccg cttcaaaggc tgctgctgct tgatagatgg tttcttcagt
    27061 gtatttcgga ccaattaatt gaagccctac tggcaagcca tcgacgaatc ctgctggaat
    27121 ggaaattcct ggcagaccag ccaagttaac tggaatggtc aataagtcgg ccaaatacat
    27181 ggcaacagga tcgtggttga gtgtgtctaa gccaaaagca accgtcggtg ttgttgggcc
    27241 taaaataaga tcataatccg caaagacctt gtcaaaatct tcaataatca aggtacgcac
    27301 ttgaccggcc tttttgaaat aagcgtcata ataacctgat gacaaactaa aggtcccaag
    27361 catgatacga cgtttaacct catcaccaaa gccttggcta cgagtgttaa catagatttc
    27421 atccaagttt ttagcatcgt cagcacggaa accatagcga atgccatcaa aacgttgtaa
    27481 gtttgaggac gcttctgacg aagcaataat gtaatagaca gccacaccat atttgctatg
    27541 tggaagacta acttcctcaa cagtagctcc taaagcttca aattgtttag ctgccgcaag
    27601 aaccgtttcc ttaatctcag gatcaatccc ttcgccaaga tactctttag gaagggcaat
    27661 cttcatgcct ttaatgtcac gaccaatctt agatgtgtag tctgcaatgc ggacaggcgc
    27721 tgaagtggca tccttgacat cgctacttgc aatcacattt aataattggg cgttttcttt
    27781 aactgtcgga gcaaaaggtc caatctgatc aagtgaactt ccaaaagcaa tgagaccata
    27841 gcgagaaaca gtgccatagg ttggtttcaa accgacaaca ccattaaatg cagctggctg
    27901 ccgaatagaa ccaccagtgt ctgaaccaag agataaacgg acttgtcctg aagcgactgc
    27961 tgttgccgaa ccacctgatg agccaccagg tacttttgtg tggtcccaag catttttcgt
    28021 tttcttgaaa taagaggttt ctgttgaacc acccatggca aattcgtcca tgttggtttt
    28081 tccaatgaca atcatgtctt tagcgtaggc atttgctact gatgtggcat caaaaatcgg
    28141 ctcgtagtta tacaacattt ttgaagcggc tgtggttagg atgcccttgg ttgagatatt
    28201 atccttaaca gctagtggaa tacccgacat gaggttatca gcatcaatac ctttggcatc
    28261 aattgccgca gcttgtttaa gagcagcttc ttctgaaaca gtgataaacg acccgacagc
    28321 ctcctcacga gacttgatgt cttcaagtgt tttttgagtc aattcggttg cggaaatctc
    28381 cttagctaca aggaggtcat gcaactcttc aatggtttta tgattaaaag acattaggca
    28441 tctcctccgt catccaaaat agcaggtacc ttgataaagt gattttcttt ttcaggaaca
    28501 tttttaaaga gcaaggcacg gtctgttcct tcttcagcga catcttgacg catcacattt
    28561 ttcttatctg ccatggttgt tgtaatggca acaccttcgg tatcaacttc gttcagcaat
    28621 tcaaccatgt caacgatttt agatagggtc gttgcaaagg ttgttgtctc actttctgaa
    28681 aatgataatt ttgatagctt cgcgacatgg cgaacttctt cttcagaaat tttcatgatt
    28741 tctcccatcc aagatgacaa gaagtattcc agttccaaag aacagctctg ctattctcta
    28801 aaggtagcgg aaaaacttct cacatcattt ttacatagtc tcaattatta tatcacaatt
    28861 gttcccattt accataggtg actaatgcaa ttctagaaag ccatacagca aaaaacttcc
    28921 tgactaaggt cagaaaaact tagtcaggaa gtgtgacaaa ctaaactcta tttgtcttgg
    28981 gtaagactgt ggcctgaagc tttgatggca gcctgagcag ccgccaagcg agtaagcggc
    29041 actctaaatg gcgaacaaga aacgtaggtc aggccttggc tgtggcaaaa ggcaatggaa
    29101 gcaggatcgc caccatgttc cccacaaatg ccaagtttca acttaggctt aaccgaacgg
    29161 ccggcctaat gaaacggcgg tactaaagag acggccaatc cctttctgat caaaggtctg
    29221 gaacggatcc ttgtcaaaaa tacccctgtc aacgtattct tccaagcatt ttcctacaac
    29281 atcacagaaa aagtaacgtt ctttcaagtc ggtaatatgt ttacgaaggt aataaagggg
    29341 tgctttattc taatttacca aatcctcaac gattgtgaca acatgtgatg tgataagcct
    29401 aagataaaaa tggtacagac tctagcattc aagagtttga agctttattt atattctaat
    29461 gctgaaaaga ctagagtttg tctaatggct gtgagacgat cctttaaacc atcaactcaa
    29521 atcatttctc aaacagctaa aatcctgtct tcttcaaaaa aacatgtgtt ctatctgaca
    29581 cagtccaaag tttagttgcc ttttagacag cacaagaatc atcaggacta attctgacca
    29641 gcatgtcaca tacctcatct acctaaccca tacatagggt aaaaccacat agagcaatga
    29701 ttacggttac caaactctta gtcactgaat caatagtttg gtaggctctt ttagtaatcg
    29761 ttaataagct tagcaccaag aacctgctca aagtgagcca aagaccactc ataagattct
    29821 tttgtaaggc tagcgacagc cgatttaaca atctctaatt gataaccaag atgataagcg
    29881 tcaatagcag tatgtaagac acagatatca gataaaactc ctgttaacac taattgagtg
    29941 atacctcttt ctcgtagtct aatatctaaa tcagtccccg aaaaagctga ataataacgc
    30001 ttatcaatcc aaaaaactct gggatgttgc ttcatataac tgtaaacttc agctagtgga
    30061 ccataaagat ggcgtccagt agttcctttg atattatgtg ctgcaaataa cttactctca
    30121 ggatgccaag gatcattttg atcatgacaa tcaatagcaa aaaaaatata gtctccttga
    30181 tcaaatgccg ttttagttac ctctgctatt ttagtggcaa tagcctgagc agatttacct
    30241 gcacttaatt taccatcatc tgctacaaaa tcatttgtgt aatcaattga aatcaatgct
    30301 ctcatcacta tctcctaaac agggaaacct ctccccttat ctcttatata tggcattgta
    30361 tcagttttta ttacaggtat caagacatct atttgcatct accattaaca gcaaaaaaca
    30421 tctcttgaaa agagatgttg tctttttcta tttaaaattc ttttaattta gcaaaaatac
    30481 cttcgttgat aactttgagg tatgtccctt tcataccaag agaacgactt tcaataatcc
    30541 ctgcactttc tagtttacgc agagcattga caataacaga acgggtaata ccaatacgat
    30601 cagcaataac agaagctgtc aatcgtcctt cattaccatc taactctcca agaattgctg
    30661 caacagcttt catttctgaa taagaaagcg tattaattgc catgttgacc gctgtttgtt
    30721 tacggatggt gtcttctaag ttttctgtct gaagatttaa tagttgaatc cccacaacag
    30781 tacttgagat ctcaaccaaa atcaaatcat catcactaaa ctcatcgtca ttacgccaga
    30841 taatgagtga tccaaggcgc atccctccac cataaatcgg cgcaatagtc gttagacctc
    30901 ctggataagt gtctttagac tcaacaggga atatagtcaa ttcattttcg acagaaaggt
    30961 tagcttctgt atcgtaaact cggctagcag cctttacata agtatctgga aattgtttag
    31021 cttcaaaaaa ttcctcaaca cgatcagtgt tagttttata tttcatggca taaccaagca
    31081 gtgtgccgcc gccattgata atacaagcat tgcagtcaat gatatctgct aggcgagatg
    31141 ccattgtgtt atacggtaat tctgtttcta ggctatctac ggaacgctgc aaaatagatg
    31201 tgattttacg agttttttct aataagttag gcattttttc cttttccttt gaattatttg
    31261 cgctttcatt ataacaaagc taactcgctt ttgcaaggaa ttatcagaaa attttctatt
    31321 cttactacaa ttccaactat tgatgcctta ttatcacttc atttaaagga gataagcact
    31381 tgcttgttag agcatagggt cacattcttt taagaaacgt tatttttatt aatcaaagat
    31441 gagcattgca ttaacgtcta tactggtata agacacgtgt aatcttttct tggacatctt
    31501 ctaattcttc tacacttggt aggtaaacaa tacggaagtg atctggatct ttccagttaa
    31561 aaccacgtcc atgtaccaac atcacttttt cttgctttaa taactgtaag acaaattctt
    31621 catcatcatc aatacgatac atctgacgat caattttcgg aaataaataa agacctgctt
    31681 caggtttaac tgccgataag ccagggatag cattaatagc ttcataaata aaattacgtt
    31741 gctcaaaaat acgccctcct ggcagtaaca gtgcatcaac tgattgatgg cctcctaagg
    31801 aagtttgaac aacttgttgg gctaaaacat tggagcataa ccgcatattg gcaagcatgt
    31861 tcaacccttc aatgtaacct ttaacatggt ctttaggacc tgataagacc atccatccaa
    31921 cacgaaaacc agcaatacga tgagatttgg aaaggccatt catagataca caaaaaacat
    31981 caggtgccaa acttgcaata gcaatatgct ctttaccatc catcaccaaa cgatcataga
    32041 tttcatcggc aaaaataatc agctggtgtt ctcttgccaa agcaacaatg tcttctaaaa
    32101 tctccttagg ataaagagct cctgttgggt tattaggatt gatgaccaca atagctttgg
    32161 tgcgactcgt gatttttgat ttgatatcag caatatcagg ataccaacca gcttcttcat
    32221 tacaaagata atggaccgct tttcctccac caagactcac acaagccgtc cataaaggat
    32281 aatccggcat tggtactaaa acttcatcgc cattatctag caaagcttga agggacatgg
    32341 atatcaactc tgacacgcca tttcccaaat aaatatcttc aatgtcaaca tctgggaagc
    32401 ccttgagttg acaatattgc atgatagcct tacgcgctga aaaaatccct ttactgtcag
    32461 aatagccctc acttagcctc gcgttgacaa ttaaatcacg aatcacttca tctggtgctt
    32521 caaaaccaaa ggcagcagga ttgccagtat ttaaacgcag aattttttca ccactcgcaa
    32581 tcatgcgatt agcttcatcc aaaacaggcc ctcgaatatc ataggcaaca tgttctaatt
    32641 ttgatgattt ttcaataatt ttcatagtct catacacctc gttttccata ttataaacca
    32701 aaatacttaa aatagaaaga atttatccat caaagcttag gacagctaat cgttttaaca
    32761 caggtcttat gagacgataa tacagtcttt agtttagcaa aaacaatgga tcgctttcaa
    32821 aatgactcaa aaaagagtat aatgaaaaaa agaataaaag ctattcttgt caaactgtta
    32881 aaggaggaca gttctatgtc actaaaatat aaacgtatcc tcgttgctat tgatggctct
    32941 tatgagtctg aattagcttt caataaaggc gttaacgtag cactacgtaa cgacgctacc
    33001 ttactactag tacacgttat tgacacccgt gccttgcaaa gcgtagctac ttttgatact
    33061 tacatctatg aaaaattaga acaagaagct aaggacgttt tagatgattt tgaaaaacaa
    33121 gcacagatag caggaattac aaacaccaaa caaattattg aatttggcaa tcccaaaaac
    33181 ttactagctc acgacattcc agatcgtgag aacgctgatt taattatggt aggagctact
    33241 ggtcttaata cctttgaacg cctccttatt ggctcatctt ctgagtacat tatgcgacac
    33301 gctaagattg acttacttgt agtccgagat agcactaaaa cactctagtc tatcacaatt
    33361 ttcaaacgcc aaaaaacaag cagcatctac aacgaaattg cttgtttttt gtgctgagct
    33421 aagtctagtc aatatctttt tatttcttga tatttaaaag agtaaacctc tatttatcga
    33481 atcgttgtag tgatttttgt aattgtttgt ctaactcttt ttttatggct acttcaggtg
    33541 cgtgacgctc ttgccaatag tcaggttttt gaattttatg ggtaacgggg tcaaagtgtg
    33601 ccttgccatc tggaaaaatt ttagccatat ttgcttcatg tactgcttca aatataggtt
    33661 gtggatctac tcccatcagt acaaaagaac cataagtaaa ataaagcaaa tccgctaagg
    33721 catcaacttg cccaatcagg ggcgtttcaa catgtttttt agcttgtacc ttattagctg
    33781 cttggtcaac agcaccatgc aaatcgaaaa tagcctgtgt aaattgttgt tggtctccct
    33841 tgcttgctgc gtaaagaaac tcaacaattt cttctacttt gaagcctgac ctataaccag
    33901 cttctgaaat ggtataacta cgcggtgttt caatagtatc tgagtccatc agacgatgaa
    33961 aatctttgac tttattaaaa ttttcatcac ggcttttaaa gctcttctct atatcaaaat
    34021 ggatgagacc gtagtgagct aaggctttgg aaatcccatc attattatta gagtcggtag
    34081 tgaaatgggc tccatctttt accacagttt cagcatttcc catagcaata ccgataccaa
    34141 ctcctgataa catttcaagg tcattatctg aatctccaaa agccatcact tcagacaagt
    34201 caaatccaaa catctctccc aaacgttcaa ttccttttat ttttgattga tcaacagaga
    34261 tcagatccaa ggaataagga ctacttcttg taatttttat atgagggaac ttctcttgta
    34321 ttttcttagt ttcagcttgt gacgctacca gaacaacctg ataaataggc tcccgcataa
    34381 tagttactaa atttctaaaa ctctgaggct tgattcggcg aatcaaatgc ttaaaactac
    34441 cctcaactgt tcttgcccaa cttttgggca caaaactact aatgacttgt ccaaatgggc
    34501 tagtccccat atcaataata cgcgatcctg ctaatccaga agctgttcca agagaaattt
    34561 ctcgcttttt ttcgttggca tagcgaatca ctttgtaaat catcgacttt ggcaattgat
    34621 tctgatataa gaccttatct cttgttaaga tatattgccc attgtaagta acggcaaaat
    34681 ctaatccaaa attttctaga aaaggttgta caaatcccgg tccacgacca gttgctaagc
    34741 cgaccataat gccttgtttt ttgagttgtt ggatggcttt ttgcgttgtt ttttggatat
    34801 ttttacgatc attgagaagg gtcccatcaa tatcaaaaaa gactgctttt actgtcaaaa
    34861 ccttcttttg cctcctgtgt ttatgataga atagattata tcataaataa aaggaagttt
    34921 gacaatcaaa tgaaaaaaat cctagtctta cacactggtg gaaccatttc tatgcaagct
    34981 gataactctg gtagggttgt tccaaatcaa gataatccta tgacgaaaat acatgctgca
    35041 gtccaagata ttcagcttac cgttagtgat tttctaaatc ttccgagtcc tcacatcacg
    35101 cctcaccaca tgttatctat ttatcatcat attcaagaaa gaactgatgt ctttgatggt
    35161 atagtcatca cacatggaac agatacctta gaagaaacag cttatttttt agataccatg
    35221 gcattgccta ctaatatacc tgttgtccta acaggtgcta tgaggtcttc taatgaagtt
    35281 ggtagtgatg gcatatataa ttaccttacc gcacttagag ttgcaagtag tgataaagct
    35341 aaagaaaaag gggtacttgt tgttatgaac gatgaaatcc atgctgctaa atatgttact
    35401 aaaacacata caaccaatat ttcaactttc caaacaccca cacacggacc acttggtatc
    35461 atcatgaaaa atggcctact ttttttcaaa actgctgaac ctcgtattcg ttttgacttg
    35521 agatgcattt ctggaaccat ccccattatc aaagcatacg caggtatggg cgatggtagt
    35581 atcttgagtc tattaactcc aggtagcatt caaggtctag ttatcgaagc tctaggagca
    35641 ggaaatgttc caccattagc agttggggag atcgagcact taattacttt aggtattcct
    35701 gtcgttcttg tttcccgttg tttcaatggt atggcagaac ctgtctatgc ttatgaaggt
    35761 ggtggtgcga tgctacaaga agcaggtgtt atgtttgtaa aagaattgaa tgctccaaag
    35821 gcccgtctaa agttattaat tgctctcaac gccggactta ctggtcaaga gctaaaagat
    35881 tatattgaag gataatctag cttcctgtag aaatgtccca ctaaaacata ttagtgggac
    35941 atttctagta ctttaagctt taaattagga catctcctaa atgtctataa taaacaacta
    36001 tgtttcaaac tatgagattg tgcactcata atcatttcta taacagtttg agaccagtat
    36061 tccaataaat ccaactctta gcaatcagat accgggtaaa caagtcttta ttttgtctca
    36121 ttaagtataa gcttacttga ataataccaa aactacttgc tcatcctttt ttagtaatga
    36181 tgaagacgac ctttttctaa gaacttcttt gtcttttaaa ataaacaaag cacatattac
    36241 cctttatttt agttctcgtt tggaaaaaag aaagacattg cctaaaagat aacaaagagt
    36301 taaaccaaag gccactaata tgctagtact agaaagatgt ttatcaccaa gagacaagga
    36361 taggtgttta aacatcaaaa ctgggctaat atctaactta aaaaaatggt ttgctaaagt
    36421 agcagatact ttatcaaaaa gaaggacata aagtatataa gctgtgattg actgataagt
    36481 tttacgaagt atattaaaca aaaattgaca caaagcaata atagcaatat aaaaaggcag
    36541 ttgtttaatc atccgatcta tgactattcc atagtatgct tgaccagtaa ataaatgaaa
    36601 tgctaaagca ctaagaagat aagttaaact aataaataaa agagataagc caaaactaac
    36661 tagcagttta tagattataa ttaaagtacg attttgttgt ttgaccacaa cattattaat
    36721 cgtacggtag ttatagtcat cactaaaaaa gatacgggct ggtgttaaaa agaaaagcgt
    36781 cacaaaatca gtaataatat taatgatttg tatcatggtg acttggttag gtgtcttgcg
    36841 aaaactatag gctacaccaa cagcaatgac aacaagtagc atacaagaaa atagagctaa
    36901 acgctcttga cgtatgcgaa ataaatctgc tttaagatag gaaatcataa aaacctcttt
    36961 ctaaattaat ggtgacgctg catctttacc taacaaatcg aggtaataat gttcaaagct
    37021 cacttgatga tgataaatgt caaaaatctc aacaggcaga tctagcacaa ttttgataag
    37081 ctccattact gataaagttg gttttattag tagcatctga ccatcagtct caactctaag
    37141 ccccaattct aaaagtctat tttttaccag ctgatcatcg cttgtatgaa gggcaatttg
    37201 tacttttact tgagctttaa gctctgcttt gtccatactc ttaataactt tgcctttatg
    37261 cataatcacg taacgatcaa caactaagtc taattctgat aaaatatgac tggaaatcaa
    37321 aatcgtaata ccatagcaat ctcttaggtt caaaataatc tgacgcattt ctttgattcc
    37381 tgctggatca agaccattaa tgggttcatc taagattaaa aattctggaa aatctagtat
    37441 cgaaagacca atagccaaac gttggcgcat ccccaaagaa taatctttca cctttttctt
    37501 tttgctcact ttttctaacc caataagttc caaaacctca tgtatgcgct cttttgcatc
    37561 agttaatctc aattgcaacg ctgcatagta aagattatca tgagctgtca tattgggata
    37621 aagtgtcggt gactcaataa ttgatcccat tcgatagggt tgtaactgtt tgatttgccc
    37681 tgaatctttt ccaattaggc cagataaaat acgcattaac gttgtctttc cagcaccatt
    37741 ttgacccaca aggccgcaaa tttctccttt gtaaatatca aaagagatat cacttaaaac
    37801 ctgattttta ccataggatt tatttacttg ctcaatactt agtaacattg attgctgtgt
    37861 cattttccgc tccttttttg tacttatcga ttaatacaat atcttacaca taataacatc
    37921 tgtaaacggt tgtgacaagt tcttcttttt attaaaaaaa tataaataag aattttaata
    37981 atatgattat tttagcaata aaaaagttat actgaaaatg ggttaatact gcttcaaata
    38041 gcagtctcat cgtaaagcat aagtaaaaaa ggtcagaaat agtgacctct ttatacttta
    38101 taacagttta tctcaaagct aactaaatat ttgtaaaaca acgacttgtt ttaagttaat
    38161 cataaacttc tttttttcta atattttttg ctactaattg ccactgtttt tcatatatcc
    38221 agttaggatc agaaacaatc gctgcagaaa ctttgcgtgc ttcttctaaa ataggataat
    38281 cctcaacgat atcagctact tgaaattctg gaattccaga ctgacgagta ccaaagattt
    38341 caccagaacc acgcattttt aaatccgact cagccaaaac gaaaccatct gtcgtttctg
    38401 tcatgattgt cattcgtttt ttccccgaat ccgttttggg attagccact aaaacagcgt
    38461 atgattgttt atgtccacga ccaacacgcc cacgaagttg atgtaactgg cttaatccaa
    38521 aacgatcggc atccataata atcatgatcg ttgcatttgg gacatttacc cctacttcaa
    38581 taactgttgt ggatactaaa atatgacttt ttttatcctt gaaatcttgc attatggcat
    38641 ctttttcatc atttttcata cgtccatgta caagagcaac cttagcaatt ccttcaaaat
    38701 aagtagataa ttcagcatgc aatgctactg cattctttaa atctaaagct tctgattctt
    38761 caatcaacgg tgaaatgaca tacacttgag catctttttg caattcacct tttacccatt
    38821 ccaacacagt ccctaactgc tcgtgtttca cccagcgtgt cataataggt ttacgaccgg
    38881 caggtaattc atcaataaca gaaacatcca tttctccaaa agctgtgatt gctagagttc
    38941 ggggaattgg ggtggctgtc atcattaaaa catcaggatt ttctcccttt tcacggaaaa
    39001 ttctacgctg tttaacacca aaacgatgtt gctcgtctgt aatgacaagc cccagtttat
    39061 ggtactgtac cgagtcttgg ataagagcat gagttcctac aatcatatca accgagccat
    39121 ttgcaatagc tgctaaaacc gtacgcttaa cagcggcttt catacccgaa gttaatatag
    39181 caattgatag atctggaaat aactcttgca gactaatgta gtgttgttca gctaggattt
    39241 ccgttggaac catcaaagcc gattgaaaac ctgctgtata agctgcatac attgatagac
    39301 cagcaatgac tgtctttcct gatcctacat ctccttgcaa taaacgattc atatgagctc
    39361 ccgatgacat atcagataat atgtcatcta aagagcgctt ttgagcattt gttagaataa
    39421 agggtaaaga ggaaatcttt gtctccatag catgtttact ataaagaata ggcaaaccat
    39481 ttgtttcaga tctattttcg gctttcaaaa cttgaaggtt catttgaaag taaaataatt
    39541 cttcaaattt aatccgacgg agcgcttgct tatactctgt gatatctttt gggaaatgca
    39601 tagctaaaca agcctgacta cgacccatca atcggtattt ttccaataaa gtagctggta
    39661 aattttcctt caattccaaa tgcgcatcga tttcaaaagc tgacttaata gctttaatca
    39721 aagtagactg tgaaattccc tgagctacgc gataaacagg ttgcatgtca tcttcaactt
    39781 gagctaaaac cttcatccca gtaatagccg atttagtggc atcccattta ccaaaaacag
    39841 ctacctcttg accaagttct attttatcag ctaaataggg ttgattaaaa aaactaacat
    39901 ttaagacagc ttccccttga cgcaatttga aacttaaacg gttacgttta aaaccataat
    39961 attgtacatt agctggagta acgactaagc ctgtaatgac tgctttttca ccatccacta
    40021 aatcaaaaac agattttgat ttaaaatctt catagcgaaa cggataataa agcagtaaat
    40081 cttctactgt ataaatatct aatttctgaa atttttctgc tgattttggt ccaaatccct
    40141 ttaagttgga cataggagct gttaatatca ttatcttttt cccttcacaa aaactcttgt
    40201 cagattgaag acaaagtttg tcgtgatact ttccttaggt ggtgcttacg gcagcgacgt
    40261 tctttggaat tccatgcctt tatttttgag cctgaggtct caaaaatccc gagtggcgtc
    40321 aatctcgtat tgacgccact cttttaccac agcaaaaagc atctgttttg gctcactttg
    40381 tgtgtaaaaa tcggaaaccg gatgtcaaat cagcagagct attcatgctt tttgagcata
    40441 aaactggggt tgtctacgtt ctgactcttg tatctattat acaagagttc ctatttattt
    40501 tcagataaaa gccttttagt acttttaaac agttctaggg gctcgttaag gtagcatttg
    40561 ataaatggta tcgcagacac tacttagaag ttcttcatca tgtgaaatga ggatgacaac
    40621 cttatgttgg gtcttcagct gcatgagaag attagctaaa gccttcattt gtaacaaatc
    40681 aagtccgcta cttggctcat caaaaattaa gatatcttta tcagccaaaa gactagcggc
    40741 aatcatcact ctttgttgct cacctcctga caaactagct ggatgacgtt ctaaaagagt
    40801 cgttaaagat aaccgctcta ttacttctgt cgtccgtgga tgtcgttcat ggcccaagtt
    40861 gacttccttt gaaaccgatt ctgcaaatag ttgcaaagaa acttcttgta agacaatact
    40921 agtctttgat aaacgttgct tggcagataa aggtatgcct tgaaacttaa tagttgcttt
    40981 tttatcgtct aagataccag ctatataata aactaattgc gattttccaa gcccgtttga
    41041 tcctgtaatg ccagaaatac ttcctgcagc aaaactaagc tgttcaatac atctaagtat
    41101 tttgcttccc gctctaactg ttagatgctc aatacacagg ctatcatctg ggcgataatg
    41161 ttgactctca atcttaccag ctaacacagg ttttaggtca gacaagtcta agcgacgtag
    41221 tcccatatct tgccgttgtt catctgtcaa ggctagcaaa tcttgtgttg ttaacttatc
    41281 tgttaatcta ccatttttaa agtagaaaaa gttatctgcc aaatccatca agtaatgtaa
    41341 gcgatgctcg gctacaataa tggtttttcc tgctgctttt aattgggtaa gataggcttt
    41401 aacagcagct atgcctgcac tatctaagtt agcagttggc tcatcaaaaa gcataatatt
    41461 agtaccttgc ataatggccg ttgcaatagc aactctttgt ttttgccctc ctgacaatcc
    41521 aaacatatcc ttgttaagga gctctgcaaa agcaaaatct tctgctaaag tccaaagacg
    41581 cttcatgata acctttgcat ctagaccttg attttcacag ggaaagacca gttcgtgttg
    41641 gacttcgcga tagaaaaact gactggctgg attttgaaaa acagaggcca cagatctaga
    41701 aaatgtttca acactgtctc tgcctgcttg gcaatcagcc acatctagtc taccttcata
    41761 ttttccagca taataatcag gaattatgcc attaagaaat tttaaaaagg tagatttacc
    41821 tgaaccagaa gatccacaca aaacaatgaa ttgtccagag gcaatttgac aagtcgatac
    41881 ctgacaagct ggattttttt gatcatgata ggtaaaaaca agttgttctg ctgaaatcat
    41941 tgaagtatcg tgatgattat gataacagta atccaaatct gcacccccca atctttccat
    42001 gttaagtgtg agctaaagca ttcactggtg cctttgttga ctgctagtcc tttagttaga
    42061 ctagcgatag ttagttcttg actacttctt atcaaagata aaagcaatgg aaccattaaa
    42121 tactccaagt atcgtttagg tctgatcaaa atagaccatt ttgttaaaat aatccccctg
    42181 attgttaaag agcgatgaat aacacaacat tcttgtctaa tcattggtat gaaacggcac
    42241 ataacggcta aggtcaatag ccagacttct gggaaatgcc atttgcgtaa tccatgaacc
    42301 aattcgtaga tggtagttgt cttaatagta attaaacctg ctagtaaaga agggaaaact
    42361 aaccttcctg ctattgagac aaagctcaat aagtgatcaa gataagaagg gaaaatcgat
    42421 agcgggatta cagatagacc gatcattaac agataaacaa ccgccaactt gaacgctagc
    42481 tttttcttat ttaaagcaga caaaagtaat aagagaaaaa taacaattat aaattctaaa
    42541 aagccatcaa cacgaaaaaa gaagcaggca ttggcaagta ccaacaaaag cagtttggtg
    42601 cgaacatcaa gcctcatgat aacaatcctg atttgataaa atgtttcttt agtaaataat
    42661 gtgcaaaagc tgaccctaat aaggctcctg caagaacaat tcctacaaac caaataacat
    42721 gccctaaact aaaatcatac ataatgcgat tgacataggt catactttta ccgcgggcta
    42781 acaaactttc aacataggca tctttcaaca accacatcag cacaataggg ccactattga
    42841 caaaagcaaa aaccatataa gataggtcat taaaaaacct tgacttgtat tttcctaaag
    42901 acgcaataat atccgctatt aaaccgaaaa taatgctggg aaacatcgcg gcaaaaaagt
    42961 gaccactaag gaagaaaaaa cctcccatca tcaatcctaa taatgttatt ggcccaaatg
    43021 tttgcaattt agcaatcaaa agaaaataaa ttgttccacc cagtaaagct gcaaaggcag
    43081 gggcatataa catatttcct gagcgatcaa aaaagatgtt aataaacgtg cctagaccaa
    43141 cacaaataaa gtagagcgcg gcaaatgcgc ctgttatcat aatatctttt attgttaact
    43201 gtttcatttt ttattcacct cttttaggga accatttttt acgcaaaata gatgatcagc
    43261 acaagctagg gttgatggcc tgtgagaaat taagaagacc aatccttgac aatgtgtttt
    43321 aattaaatca agcaagatag cttcatttag agaatctaaa tttgacgtgg gttcatcaaa
    43381 aatatagcaa ctcgcatctt tcaataaagc tcgcatcaac tctaaacgtt gaccttctcc
    43441 agctgaaaaa tcagaaggac tcttgataat cgtatccaaa ccttccttac aagctaacag
    43501 tctgtctttc ataccacaag cctcagctaa attccaaatg gactcatctg aaatatcttg
    43561 acggccaaag gtaagatttt cacggataga ctgttggaaa agctgcgctg tttgtggcac
    43621 ataagcaata gtatcttgta atttagcagc atttagtaag caactattcc tatcattaag
    43681 aaaaatatct cctgtcttcc aattatacca tttcataatt aatttcacca aagttgattt
    43741 accagatcct gattcgcctt taatgccaat aatccccttt tcttgaaagg taactgataa
    43801 atccttaaaa accagctctt ggcgctttgg ataagcaaaa ctgaggtcct caaaagaaac
    43861 actccttaaa cgatctatct gttttgtgcc ttcgtctact atgacatttt cgtctagaag
    43921 gtcaaaaata tttcgagccg cattcatagc acgcttaaag cctaatggca aacgtcctag
    43981 ttctaaaaaa ggagaaaacg aagcagtgaa agcaataaaa gttaataagc ctttatcaaa
    44041 tgataagctg tcatggcata tcccatcaaa aaccatataa gaaaatgcta agatcattaa
    44101 gccaagccaa aaaaaagtca atgccatttg caaaaattgg gcttgcgcta cgttacgatc
    44161 aagagcattt acatgattac ttttttttat taatcgttca aattgctcgt ctaatacctg
    44221 aaattgcaaa agatctttga ctgatcgtaa actctctaaa aaataagaca ggtaatcttt
    44281 tcgaccttca ttttggcttt ttagtaaaac ctgtaaaata ttagcaaaat aaatgggtat
    44341 aacaatggct aaacaagcat aggttgccaa agctaataag gctaactgcc aactactttg
    44401 acaaaagtac cagaacatta aacctgcaga caatattgct gtacaaatag gtgcgattgt
    44461 gtgggcaaaa aaaacttcta atgcctcaat atcttctcca atcattttaa gcaaataacc
    44521 actgtcttga ctatccaagc aagctggaga aagagctctt agtttcttaa agatcaagtt
    44581 cctaaaagct gctaaactat gaaaagcaac aaaatgacca aaataatgct ctccataacg
    44641 aacaaaacct cttaaaaagg ctagagcaat caaaagatat aaagctaata ttggaatcac
    44701 ttcttgtcta atagctagta gtcctaaata agctattcca gttggaatac ttaccgtgat
    44761 gacaaaaccc ataacagcaa agccaacagc caagataatc caaggtagca gagttttcat
    44821 tagggttaat aaacgccaaa ccaggcttaa ggtagatctg ttaggtttag ccataaatac
    44881 ttgcctccag tcttgcttga gtatcaacta ggtgacgata agttggttgg tcccgataaa
    44941 ggtcgcaagg tttgcctaaa caagcaggct gccctgtgtt taaaaagagt acttggttag
    45001 ctcctttcag tcgagacatc ttatgagtaa tcacaataac tattgctgtc ttagctaatc
    45061 tcgttattaa attgtcaata atacgttcat tttctgcatc tagactagat gttgcctcat
    45121 caaagatata aagagacctc ttacttaata gagctcttgc gcaaatcacc tgttgctttt
    45181 ggcctggtga taacaggtta ccattttcac caactattgt gtcaagacca tctggtagcc
    45241 agttgatgaa gcttaacaaa ccatgttgat ctatccaatc taagatttct tttttagaga
    45301 gatttgctgc taaccttaaa ttatcgtaaa tgctacggtt caataaggta gattggtccg
    45361 atacataaag aacctgctgg ttgatagttt cttgcgacaa attgtcactg tctaaaccgt
    45421 caaataaaat atgcccagtc gttgcagact ggcgtttcaa gaggagttga gctagacttg
    45481 tttttccttg tcctgacacc cccgcgatag ctgttagttg gcccttcgtt aatgtcatgg
    45541 taaccccact aagcactgtt tttttctcat aagctaaaga aatattttgg atgtcaatct
    45601 ggttaaagtt tattgctgtt ttactcttgt tatctttcct tgctggaaca ctatccaaga
    45661 aactaaagat acggtcagcc attttggtat tcatcatgac caagtgcatg ccataaccct
    45721 gctcacgaat cggtgtaaaa aattctgtag caatcaagag aaaaaagagg aaattaaaaa
    45781 aggataactg gcctgttgcc aaagcttgaa cggctaaaaa acctgacaaa ccaattccca
    45841 gatacataac tgcatccata taaccaactg cttgtaactg aaagccaagc aaagacatgg
    45901 tagcctttcg aaactgttct gccttacccg aaaattcttg ctcgtaacgt tctattgctt
    45961 gataagaata cagtgtatta agacctttta agtcatccat aaataaatta ccaacatcca
    46021 tataagaaga ccaataatga ctcataattt gcttagaccg cttttgcata gcaacgattg
    46081 aaagtggaat cagaggcaga actcctaaaa agacaaggcc tgccaatgga taaattaaaa
    46141 agactagtat cataatagtt gtgcagttcc acttggttct catagacaaa gacaaatagt
    46201 aaccataata agtatccaaa ctatcaatcc cctgtgaagc caacgttaaa atatcagcat
    46261 cactggcatg agcatcaaat tgcccgtcta aatcaataaa agcctcaaag aaagattgtt
    46321 tgagtgaatc tctagcaaat tgtgaagcga tcccttgcag ttgcttgcct aatatagcaa
    46381 gaacaaagcc taccacattt aaaagtagga gtaaacctgc caagcgtcct aaggcaatag
    46441 tatgacccaa aataaaggtc gaaaacgttt tggcaatgag gtaaaaactg atcatcctca
    46501 tcacaaattg taaccaagat aaaaaggctg acacataaag caaatacctt tttggtgcaa
    46561 ttcgttcacg taatcgtttt aacaatcttt tcctttttcc ccttgatatt gtatcttctg
    46621 tttccatcat ctgttcttgt tcctatctct cctttgagtt ctaatatcat tggtttcatt
    46681 gaccaatgaa gtgaggacaa actgttgacc atttctctca acaaagggca attcaacacc
    46741 aaagacatct ctgataaact gttgatcaag gaggtctctt ggttgccctt gggcataaag
    46801 tcgcccatct ttcagtccaa taagatggtc tgaaagagac aaggcctgat tgatgtcatg
    46861 taatactaac acaatcgtta ggcctagctc ttggttgatt ttagtaatca gcttgagaat
    46921 gtcaagctgg tacttaatat ccaaataagt cgttggctca tctaaaaaaa taatatctgt
    46981 atcctgggca agggccatgg caatccaaac cctctgctgt tcaccaccag aaaggtgttg
    47041 gatgtcacga taaacataat cactcaaagc cgttacttct agggcccaag caaggcgttc
    47101 ctcatcttct ttggtagtag ttttaaaaaa agaacgacgg gcaagcctag ccatggctac
    47161 caattcaccc actaacaaac cttcgaccac ttgatggtat tggtgtacca ctgccacttt
    47221 tttcgcaaaa gccttgagag aaagcgttgc taattcttcc tgctcaagcc aaacctgccc
    47281 ttgttttaac ggaaggtttt tggttaataa ttgtaataag gttgacttgc cactgccatt
    47341 tgcccccata atagtggtaa ttttcccttt tggaatgcta aaggtcaggt catctaaaac
    47401 aagtttttcc tcataagcaa aggaaaggtt ttgcacctga atatgactgc tgttcttact
    47461 catataatat cagacctcct tagcaggtaa ataaagtaag gcccgcctac aatactcatt
    47521 ataatcgcag ggctaatttc caatgggtaa gcaagacttc ttcctaaagt atcggctagc
    47581 aaaaagacaa aggctccaag caaagctgaa aaaggaatta agatttggtg cttacttcca
    47641 accagcaagc ggctcatatg agggacaatc aagcctagga aagaaaccac tccaacgatc
    47701 gaagtggcta ccgaagccaa taaaacagca accaaggaaa ttcccaaccg taacgctgta
    47761 gcatcgattc ctaaatgacg aatcacctga tcatctaaaa gaagaaggtt acaagttttt
    47821 gacaataaca aagctagcaa caagccaatg aatgtataag ggaataaaac ccctacatca
    47881 gcccatgttt tttgactaat atgacctgct aaaagagcat tgaccatggg actagctgag
    47941 gtgaaaaaac tggttaaagc agttgataac cccataaata aagcattaat agcaatccct
    48001 gttagaataa gccgaatagg attaagccct ttcttccatg ctaaaccata aatcagcagg
    48061 aaagacactc cgcctcctaa aaaggatacg attggaccat acagcagcaa ctgcggtaga
    48121 agtaaactag agactaaaac cataaaacta gcaccactac aaatccctat aatagcaggg
    48181 tctgaaatag gatttttcaa cactgcttga aaaagaactc ccgaaacagc tatccctgct
    48241 cctgctaata aagcaatgac aattcttgga aagcgcaaat cataaatcaa agccacttgg
    48301 gggtcataag ccacaaacag tcccttgaca attgcctcat aagaaaccgc caaaccacca
    48361 agggataagg caataaccgc caaaaacagg aggctgagaa ttaaaagaac tagataaaga
    48421 ccacttctga aacgtttttt agtcagtagg gattgatccc tttgtaaatc tgatgctgtc
    48481 atgttacgaa tgatctccca cgtggtcaaa aagctgtgtt aaggtgtcca aggcttctgg
    48541 gtagttcaat ttagcactca tgccaaacag ggtattgtcc aaatcataga ctttcccttc
    48601 cttgactgcc gtaaaatgtt tccaaatatc attttcagca aattctttgt caaacatcac
    48661 ttttaccttg tctggaatgg cgtgagctgt tcgtaaaatc aagtcaggct ccttagccag
    48721 catgtcttca ggattagctg atagaaattc tttctcatct gactgataaa cattctcacc
    48781 acctgccaag tccaaaagat tccctacata agattggttc gtcgccacca aataactacc
    48841 tggcaagccc ataagaataa gcactttagg ctttttcttc cccttacgtt tagcttggaa
    48901 agcacgataa tagtcctggt attgctggcg caattctttt gcttcttgtt gacgttggaa
    48961 aaggttccct aaatcatcaa tggactggta catgccctca acacttcgta agttcaaaaa
    49021 accatactca gtatccaatt tttgatactt gggttccaaa tcttcttgta aagaattggg
    49081 actcaaaatc caagttggtt tcaaagaagc aatcaactct atatcaggat tcatgggtaa
    49141 acccacacgc ttaacagcat catagcgttt aggaagggta tataatttac tatcacaaac
    49201 cccaacgagg tctaaattta aacggtcaca gatatcaacc acagcaaccg aagtggctac
    49261 aattctctgc tgttcagtct ctttagccgt tttagggtgc tgattcacac aagctaccaa
    49321 aaagaaggcc attaaggcta gaccaattcc tttacatcgt tttatcattt tttttcctct
    49381 ttttccaaac ccatacagca aaccctccta acatcagaaa aaaagttgga aagtagtaaa
    49441 tcatgattga taagtctttt ttagaccgaa acttatcttc tttttttaac tctaaagaag
    49501 tcgttaagcc catcttagaa ggaagaattt ttttatctga tagactcttg ttatttgatg
    49561 agttggcttt aggcttattc tgagttatca tagcacctgt gtgagactca tcttgacttt
    49621 ctcctagttt tgtatcaaca ggcttttgat tgtcttttac ttcttgattt tgagaattgt
    49681 ctgtttcagt aacaagctgg gccaacatat tacctgaata cttttgtatt aactctgaag
    49741 ctgacaggta aaagaccact tctctgccca taggttcaac aaacatgctt cctcgaatga
    49801 tactatttac agtaggcaaa ctaatagcaa tatctagtgc tgtcccattg gtatcagtac
    49861 ctttttgggt gatattgtaa tcaactgcct gaaagcttcc agttcctcca ggttgtatcc
    49921 agaactgata attgcccgaa taatcagcta agctcatacg aaaagtaaga acgatctttc
    49981 cagcatcaga tacttctagc atggcatcac tatagacagt cccttcaacc ataccttgac
    50041 caatatcaaa ggaatgctca cctccgctat cttctatctg cccagatatc ggatgacgat
    50101 aatttctctg aataatacat ccataaattt gacctttatc tgcatacaca acacctgtca
    50161 ttgtcgataa acttatcatg aacactacta ttacctgcaa caattgcttt attactacct
    50221 ttgtcatatg ctcctcttgt ctatcttttc ttaaacatct tatttcattt tttaaatgat
    50281 tcccatttta taacatctcc aaatgtgaaa aacacaccta tcttgcgact acttcaacct
    50341 gtatcaggag tcctgtcgga aataggtatg tttttagctc ttgctgacta gcttttttgt
    50401 tatttcactt ggtactaagt ttcttattta aataatgtct ttcgaccaat aatgaatccc
    50461 agagctacga tcataaagct agatagacct gcaattaagt gataacgaga gctactttct
    50521 tcaccatttg attgttgatt ggaacgatgt ttcttatcag attttttagt cttagtatct
    50581 tttgccgttt taccttcaat tgatgtttga tggtcacgca ctaactgttt caatttctct
    50641 gccttatcag tatcatctgt cttagaagtt tcttgagttg attggccggt tgctttttta
    50701 gccaggagat cagttaagtt agcaatacca gtagctgctg aaggaggact tgtaggtgtt
    50761 ttttcttgtt gacgattttg aggtcctttc aactgatctg ttgaagttag atggctattt
    50821 tcttgtggat tattagtttc tttgacaacc tttgccttct ctgtcgtaag gcttgcccag
    50881 tctaaacgca taaaaacggt ttgaaggcca gacccttttg aaatggcatc catgataggc
    50941 acaaagacct gtaatggcac aagtccgtct ttcttcgctt gttcaatcaa tttcatacgc
    51001 agcacttttg gatagttttt tccataacga tctgccaatg gtaggccagt tacatccgtg
    51061 aaataagaca caacctctgc cttttttgtt cgaccaactg gtttaccagc taaatctctt
    51121 tggtaaccat ctacgaaata gctcaattca ccaaggtagc ctaacatttt accaaccttt
    51181 atccctctaa actcaacttc taaataggaa acaccttttt taactaccaa agtcactcga
    51241 tgattaatag ccttgtttga catggactca gatgctaagt cagtttttaa catgctggca
    51301 tttaaatagt aaataccatc acgcaattgt ttttgattta atgctctaag gcctttctca
    51361 actaaatctt tctgatgtga atgtggtcct ttcgccacaa ggatatcatt agatgtcaaa
    51421 tagatatgtt ctttttgagt agcaaatttc tttgttatta aagctttgcg aattcgatat
    51481 gtacctggat cttttaaaga aaactctccc gttaagtcat ctttcggatc atttgagaga
    51541 agcttttcgt taaccgtcac atactgtcca ttggaagctt ttttttgcaa ctgaatcaca
    51601 atactccaat cgacttgcat atcattaagt aaagaaacag tatctgaacc tttttcttgt
    51661 aacaattgtt gatattcttc aatagacact agttctttat caatggcaga atttgttttt
    51721 tgctcccaat aatacaaatc taaaagactg aaagcttgat gatattttat tttttcgcca
    51781 tctaaagaag cttcaagttt tgcaatatgt ttttgtggag tcagtttgtg ttgtccgata
    51841 agagctctta cttttggact cacacttttt atctgattga acttcacatc taaattaagc
    51901 gtttcaacat ctggaaatac tgattcttca acctgagtaa gcaagttatt gaaaaaatca
    51961 agttttgtta attggttatt ctgtttaaat ataccatttg gaagatttga aatttcatta
    52021 gttgataaat cgagtacaga taatttagga agatttttaa atgaaatatt atcaatacga
    52081 gtaatatgat ttctacttgc cacaatagtg cttaaggcgc gcaatttttc tattgttttt
    52141 ggcagtagtg ctaaattatt ttgagataag tcgataaaat taagtgatgt tagaggctct
    52201 agcgcttttt caggtatctc ctcaagacta ttttctgcga aacctaatga agtcagacga
    52261 gacaatcctt caaatgggtt atcacaaagt cggccaatac gattcttgga aagatcaagt
    52321 tgctccaggt gatgaagcga ctggaatagt cctccttcaa gagagtgaat aaagttactt
    52381 gataagtaga gttctcttaa ttgagcattg cttttaaatg tatctttgtc tagataagtt
    52441 aaatgattac ttcttaagtt aagaaatcga agttgcttca tttgactaaa taactctttt
    52501 ggaatttccg taatttggtt tccatccaga tgcagttctg taatattttt agcatgtttc
    52561 aataaagaaa tatctgttaa ctcgtaatgg tctagacgca actcacctcg aatctgttct
    52621 aattccgttt ttgataattt accatcgccg tctaaatctt tgccaagttt aactaaaact
    52681 ttttcaagac gttcagtccc aacccctttt tctttatcat cagtttctac ctgataacca
    52741 ctccaacctt tggtaacggt cttactaaag gtcatgtcaa gtttggtgta tttgtcatag
    52801 tggtttaaat cactttcttg acctcccatg gctgatacca aaacagcacc tttgtgtaat
    52861 ttatccaaat catcaatagg catggtaaat tcgcttcgaa tatagctacc attgatatct
    52921 ttttggccaa cttgtttacg cactgctgct gggtaggtcc ctttgctttc aatagaaaag
    52981 tcaatcaaaa attgtcccaa agcagtatta agcatggaaa tttccattgt accatctgct
    53041 ttaaccacta atttggctct tttatcaaaa gcaccttgaa gcatggagga ctcttctgag
    53101 ttttctttat tagctttaaa gtttagcgta taggttcctt ctgtgagatt gttaatagaa
    53161 acctcacctg cttgataaga ctcgatggta tcttttaaca gtcgatgagt atcggcgagt
    53221 agcttactat ctttgatttc tttgtaagaa tccttgatga cttgaagttt ctcagccaga
    53281 tctttgaccg cgtctttgtt gctttcttta gcaataatcg catccgcttc tttgatagct
    53341 ttttccaaag tggtgacatc caactttgtt aattgtctgt cttcagcagt cacatgttgt
    53401 ttttgtttgg cagatacaaa atggatttga ccatctttct tggtaacggt aatggtaatg
    53461 tcttcaaatc cttttgagga tatcacgatt gtattttctc catctttgaa agcttttgtt
    53521 ccaagatgaa gccctgtcat attcgagacc cagccattag tatcttttac agaatctgaa
    53581 ataagatctt tataaactgt accattgact gtaacctttg tgatttgctg agtcaatgct
    53641 tttatctgtt tgttatcaga ataacgatca atttctggaa ataaaattgc accatcttct
    53701 tggctcaatt ttgttattaa tgacaagtta gcagtatttt tcccagattt aacaactttt
    53761 tgtgtgcctt tgttttgtgg cactggttta tcactgagca catctttttt taatgaatcc
    53821 tgatgatctg ttgttcctaa tttttgagct gaaataaagg tcactttatc gcccttttta
    53881 ataaaggtaa ttaggatatc accatctttt ttattaacaa tagtcaattc atgcttaccg
    53941 tctttaataa ggttagcatt gatcttaatc ccttggtagt taatatcaaa ggttcgctcg
    54001 ccttccaggc ttttttcata gacatcatta tcaacaataa ccttttcaat atgtttataa
    54061 tactcttttc cagctgattg actagcgtaa gggcctatct cttcaactaa aagtcgatta
    54121 tcctgagtta aagctactgt tgtcacgagt tgtgactgaa ctaaaggctc ttgtgatttt
    54181 acagtttgag tagcctgaat gagaacaagg gcagatattg ccacaaacgc acatttgctg
    54241 atttttttca ttttcaatca actttctaaa attttttatg aataagctaa cttttttatt
    54301 aactgaactt aatctatcac tttgtgatta ttttgtcaag attgtttcca atggtccaat
    54361 tgtctgttaa aaagctccac tatgtgagcc aagacactag caataagcct ggattgataa
    54421 tgatgatatc tctgataaaa gaattcctct acaacactat tactgagata aagctagcct
    54481 taggatagtt aatactaggg ctgattcaat cattacttca ttcacaaaac atgtaacacg
    54541 ttataagctc cataattatg ttaggagaca acatgagatg tcactactgc atattcatca
    54601 caataaaaaa aaagacaata gtcctaatcg tgctattgtc tcaaaatcat ttatttactt
    54661 gaaactttat cgtgttacac caacagttta aaaggcctaa ctcccgctaa gaaaattaag
    54721 ccttaagaaa agttattagt tattagtttt tactcttgcc aataacatat gttagctgtt
    54781 cagcctgctg agctgtaaag gtacgataag aaatcttacc taagccgata cagttagact
    54841 ctgaaataag aatagaccca tcttttctaa catcttctac aattgatacg tggccataag
    54901 tgccatcagc gcctgcttgc ccgggtgcaa atgaaatagc ataacctact tttggagtct
    54961 ttgacagggc ataccctact ttatacttcc aatctccacc atttcccata aaaggatcaa
    55021 attggtaacc caattctttg gcgcgattat acacatacca agtgcattgt ccccaagcat
    55081 aactcgaagc ttgataaccc aagacatcat aactcttaga gagcttataa cctgctggca
    55141 cagatgcaaa actagctgat gactgcactt tcaattcggc tggaatggct ggtgtgccac
    55201 catggtcatc aatccactta tccaggtctt ccataatttg tgcgcgacgt ttaccactac
    55261 cagtagtatc agtaaaataa acacccccgt cacttgcaaa gtttaattga cctcgtgaaa
    55321 acttagccgc ttttaaatct tgaagtgcaa aattgctatt tttgttttta ataatggtat
    55381 cttgtgtcat tttgacaata gcactatcat cattaaactt acttgcttga gtcggatcta
    55441 gatcaaaagc tgcatagcca aacatattag ctccaagcaa agtcgcaatc ccttgagttc
    55501 ctaaagaact ctcagacatc gcaatagcta cgatagctcg aacatccagc ccacttttct
    55561 tttcccattg caatagcttt tcaccattaa tacgtgtgct gtcataggca atgcctgttg
    55621 attttaagta actatcaatc tggtcagctt taataccata acggcgagat aaaagatggt
    55681 gggtataggc atttttacca ctccaatgct ctacatatgc cgcgtatgtg ttgacagaag
    55741 ggatatctat ctcactcaaa tctaaatctg atacgtaagg tgacaacgac tgaataggag
    55801 ttcttacctc tggcaactgt ctcgacaatg aagaagcagg tgccgtatca actttagatg
    55861 gtgatggttt gggctgatca gtcggttttg gctggtcagt tggtttcgaa tggtcagttg
    55921 gtttcgaatg gtcagttgat ttatcatcta cctggttttc tgcttctgcc ttgttgtccg
    55981 aagaacctac agcagactga ctagaatcgc ttcttttttt atcatccgcg ttaacaagac
    56041 tattagagtt tgtttctgca gaagcatcaa ggggaccttg gtcagtttta tctgatgttg
    56101 taggtgctgc atttttatta ttttcctctt ttgaagaaga atcactggtt tcatttgtag
    56161 ttgctttatg cgtctcaagc attacatctt gagccaacac tgtcatgctt tctgctgtcg
    56221 gggctaagag acttagtagc atggcaactc ttaatagttt gtttttattc atatattaat
    56281 tagtcacttc tttctaatgt cctcacttta ttataacatt aaagataagc acaatgcaat
    56341 tatttttacg tgattttctt aatatatccg aggaatacgg tcacttaaaa ggcatagaac
    56401 ttcataattg attgtattac ggtaatttgc gatatctgtt gtagaaatat ttttttgctg
    56461 attgctgcca atcaaagtga cttttgttcc taaaggatat gctttgggaa gtcgtatggt
    56521 cagttgatcc atcgatacac gccctataat ttcacagaat tgtccatcaa ctaacaccga
    56581 aaagccttgc atgttcctgg tccagccatc tgcataaccg attgggacgg tccctacata
    56641 ttcagacttt ttggcagtat aagtagctcc ataaccgact gtatcaccag ctgaaatcat
    56701 cttgacatgc actaagctag attctagaga taaagcctct tgcagtggaa atggtaagct
    56761 tagatcagaa ccacttggat tcaaaccata actgacaatt cctaaacgaa cagcattaaa
    56821 aatggtatca ctatgccaga tacttgtggc tgaattacta gcatgtacta aacgaggctt
    56881 atcctcaagt ccagctatca gctttttaaa aaactgtaac tgctggttaa atttagtatc
    56941 atctgcctca tcagctgtgg caaaatgagt gaaaatccct tcaacttctg cccccatgct
    57001 cttcaagcca gcaatcagat tatcaacttc tgttactgag cgaagcccga ttcgtcccat
    57061 gcctgaatca attttgatat ggaccttaag gcctttcaaa tctggccatt cttgcttggc
    57121 catcgccagc cactctaaac tagccactgt cactgtaacc tggcgagtaa tcgccaactt
    57181 tagctcattt ggcagcaaaa ccccaagaat taaaatctct ttatcaatac ctgcttgacg
    57241 taattgcaaa gcctcatcaa gatttgacac acagtaccca tccacttgag gtaggagtgc
    57301 ttttgacacc tggacagcac catgaccata agcatcagcc ttgacaactg catacgtttt
    57361 tacccctagt ggaatatgct tttgaacact ggcaacattc tccttaatag cttgtaagtt
    57421 gacccttgca actgttgggc gatggaaact tgaaatcatt ttttatcctc caaaataaca
    57481 ctagcctgta cataattgcc actatgtgag atgctaataa aactatttcc tttaaacgga
    57541 gattttgtca gaatgggaca tcctctaaca tcatttaaaa tctcaatatc ttgaaaggtt
    57601 aaccgcccaa tacctgtccc tatagcctta gcaaaagctt ccttacctga ccagcgtcct
    57661 gccaaatagc tgagtcgacg tttgtaagga aaactctcaa aaatagccaa ttcctgctca
    57721 gttaaaattt tttgagcaaa gcgaggattt ctttgataaa ctttttcaat agctgaaatc
    57781 tcttgtaagt ctattccatg tccaacaatc attactttcc accaaacctt atttcatctt
    57841 aatgttagaa gatttaaaca gtgagaagct gagaattatt ctcagcttct ttctatatac
    57901 ctaactttgt cctgttgttt ctcgttctta tgagaaggat ttacgaccgt gacaattttt
    57961 gaattttttg cctgaaccac atggacaagc ttcgttacgc tccactttgg gtaaatcatc
    58021 ggtgttagct gactgctgcg attggatgtt ttgaggtgct gctgttgtgg cacgttgact
    58081 tgcacgttca cgttcttgtt cgtgaatttg tgctttcatc atggtacgtg ttacatcaaa
    58141 ctcgatagca ccaatcatat cttggaacat cttgaaacct tctgcttggt attccaccac
    58201 agggttattt tgagcatacc ctcgaagtcc aacagcatta cgaagttgat ctaaggcatc
    58261 aatgtgttca gtccatttgt tatccacaat catcaaaatg agtacttttt ggaattcaat
    58321 aatagcttct tgatcacgaa gttttgatag ttgctggtcg tagatagcaa gcgctctttg
    58381 ataaagcttc tctttgattt gttcgtcttt taaaccacgt aactctttag cactgataga
    58441 ctcttctgga acaagtgacg tgcgtgcaaa ggtcacaatg gcatccacag catccttacg
    58501 attgctacgt gcatgagcat ctacagcacg gtcgatagta cgcttgatca tagctttaat
    58561 ttctgggcca agatctcgat tagcagttat gacatcacga cggttagcat agataatttc
    58621 acgctgttca cgcatcacat catcgtattg taagacctgt ttacgggtat cgtagttatt
    58681 tccttcaacc cgtttttgag cagattccac ttgacgccct aacatacctg atttaataac
    58741 agtgtcttct tcatctagtt tcatccgatc caaaaaggct tttatacgat cagagccgaa
    58801 acgtctcatc aaatcatctt ctaatgaaag atagaattgg gattcacctg gatctccttg
    58861 acgacctgaa cgtccacgaa gctggttatc gatacgacgg ctttcatgac gctctgtacc
    58921 aatgacacat aacccaccaa gttcacgaac accttcacca agcttgatat cagtaccacg
    58981 accagccatg ttagttgcga ttgtaacagc accacgttgc ccagcattca taatgatttg
    59041 agcttcttta aagtgatttt tagcattcaa aacctcatga ggaatccctg cttcaaccag
    59101 cttgcgtgaa atcaaatcac tagtttcaac agcaaccgta cctacaagga taggttgtcc
    59161 ttttgcatga cgcgttttaa cgtcttccac aactgctcta aactttgatt ctaaggtcgg
    59221 gtaaagcaaa tcagtgtgat caatacgggc aattggacga ttggttggaa ttggaataat
    59281 acgcatgtta taaacttcgc gaaattcttc ttcctcggtt ttcgcagtac cagtcatacc
    59341 tgccaatttt ttgtacatac gaaacatatt ttggtaagtg attgaggcgc tggtttttga
    59401 ttcttcctga atacgaacgc cttcttttgc ctcaatagct tggtgcaagc cgtctgagaa
    59461 gcgacgccct tccatcgtac gacctgtaaa ttggtcaaca ataagaatct caccatcttc
    59521 gctgaccaca taatcgatat ctaacaacat aatatagttt gcacgaaggg cgttgtctat
    59581 aaagtgagtc aaggctacat tttcaatatc gtaaagattg ctcaagttaa aataactctc
    59641 agctttatca atacctgaat cgcttaatcc aatcgtttta gtgggcacat caataacata
    59701 atccactgac gtcagagttt ttacaaacat gtcagcacga atatacaatt gattggtttc
    59761 agagctaaca gcaccagaaa caattaaagg tgtccttgcc tcgtcaatta agactgagtc
    59821 cacttcatca accaaggcaa aattgagtgg gcgttgtacc atgtcttcct ggcgaacaac
    59881 catgttgtca cgaaggtaat caaaaccgac ttcagagttg gttgaataag taatatcaca
    59941 attataagct tcacgttttt cagcaggaga cttagcagct aggttgatcc caactgaaag
    60001 acctaaccag ctatacactt cacccatttc ggtagcgtca cgcgttgaaa gatactcatt
    60061 aacagtaata acgtgaacac cttcaccagc aatagcattg agataaactg gcatggtagc
    60121 tgtaagagtt tttccttcac cagtacgcat ttcagggaca tccccgttat gaagaacaat
    60181 tcctcccata atttgaacac gataagggaa caagcccaac acacgttttg ctgcttcacg
    60241 aacaactgcg aaagcttcag gtaatagttg ttcgagggtc tcaccttttt gatagcgttc
    60301 tttaaattca agtgtttttc cttgtagatc tctatccgac aatgacgcca tttggtctgc
    60361 gtaggattct actttttttg caattttttc taattttctt agttcgcctt tgtcattttc
    60421 gataactttg cgtagaatat tggccattct ctttcctttc gatcatctaa tcatttcatt
    60481 ttaacataaa tatgcaggca gttcaagaaa ggttggtaaa gttatcacgc cgtacgcatg
    60541 aaa
//
LOCUS       DAUDWO010000004        59048 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.004, whole genome shotgun sequence.
ACCESSION   DAUDWO010000004 DAUDWO010000000
VERSION     DAUDWO010000004.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 59048)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 59048)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..59048
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.004"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            118..336
                     /locus_tag="VHC05_000205"
     CDS             118..336
                     /locus_tag="VHC05_000205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5401554.1"
                     /translation="MYPRIRNLREDNDFTQKFVANLLSFSHANYAKIERGEVALMADV
                     LVQFSKLYNVSIDYLLGQTDYPYRFHNK"
     gene            complement(407..550)
                     /locus_tag="VHC05_000206"
     CDS             complement(407..550)
                     /locus_tag="VHC05_000206"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401555.1"
                     /translation="MGISPTGLLRWQPERSEVSLSLFVVMADREPLYFIANNYRSYHG
                     VSH"
     gene            637..858
                     /locus_tag="VHC05_000207"
     CDS             637..858
                     /locus_tag="VHC05_000207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3173 family protein"
                     /protein_id="HEQ5401556.1"
                     /translation="MNIGFLEHTARDIIREAKRIAIKKFEEAREIDQNAVQLSKSPFD
                     NRRLGIAPKDIVEELIGILLSEESLESEN"
     gene            861..2059
                     /locus_tag="VHC05_000208"
                     /pseudo
     CDS             861..2059
                     /locus_tag="VHC05_000208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003106750.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
     gene            2217..3452
                     /locus_tag="VHC05_000209"
     CDS             2217..3452
                     /locus_tag="VHC05_000209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HEQ5401557.1"
                     /translation="MIKRWVILFFMVLTCSGFGKTVLAADFQVGAEHAIVVEADSGRV
                     LYEKDAKTPDAIASLTKLVTAYLVLDKVKSGQLQLSDQVNLSDYAFELTKDRSLSNVP
                     FDKKTYSVQDLLTATLVASSNSAAIALAEKVAGSELHFVNQMREQLSHWGITSGKILN
                     ASGLPNEVLKDNRYPGSALEEENTLSAQDVAVVTMHLLEDFPEILEITKQTEVNFAGN
                     SIKSFNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENGMRVITVILNADGSDKN
                     QNTRFEQANRLLDYVARTYCRRKILKKGSLVSERSLPIQDGQVKELPVSVAEDVTIIL
                     QQGEQVPKPKQFMISETSLLAPITKGEVVAYLTSPRITDQSVRYLKEPKRIPLKASQS
                     LKKASDLQLWWRDFLEKRR"
     gene            complement(3569..4531)
                     /locus_tag="VHC05_000210"
     CDS             complement(3569..4531)
                     /locus_tag="VHC05_000210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HEQ5401558.1"
                     /translation="MNNRHKRRQKRKAFTLINLILLFACILGLTLIFYLYQGSNKFGL
                     SDVSQFVPKISLFHHKKTAKKETTKLKKTHFDSSKSQKKAHSKLTWTKQETPVKIPIL
                     MYHAIHVMSPEETANANLIVNPDLFDQQLQKMKDEGYYFLSPEEVYRALSNNELPAKK
                     VVWLTFDDSMIDFYNVAYPILKKYDAKATNNVITGLTEMGSAANLTLKQMKEMKQFGM
                     SFQDHTVNHPDLEQASPDVQTTEMKDSKDYLDKQLNQNTIAIAYPSGRYNDTTLQIAA
                     RLNYKLGVTTNEGIASAANGLLSLNRIRILPNMSPENLLQTMEP"
     gene            4863..6140
                     /locus_tag="VHC05_000211"
     CDS             4863..6140
                     /locus_tag="VHC05_000211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HEQ5401559.1"
                     /translation="MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHI
                     VGTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRI
                     RPLTERLVRETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAM
                     VVVCPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGA
                     SIWEWQEQFQMAENASGYRFTSPLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYP
                     RLTSDHIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAVLKNNYNDKKLHILF
                     GAIDTKPIADMLVALEQIGDLQVTSFHYPNAYPLEKYPERFGRVADFKDFLALRKHAK
                     ADDFFVITGSLYFISEIRRYWKKHIEKSVLLTH"
     gene            6169..6753
                     /gene="folE"
                     /locus_tag="VHC05_000212"
     CDS             6169..6753
                     /gene="folE"
                     /locus_tag="VHC05_000212"
                     /EC_number="3.5.4.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="HEQ5401560.1"
                     /translation="MKRERLMSIDKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKM
                     YAEMFLGLGKDPKEEFTAVFKEQHEDVVIVKDISFYSICEHHLVPFYGKAHIAYLPSD
                     GRVTGLSKLARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHMCMTMRG
                     IKKPGSKTITTTARGLYKESRAERQEVISLMTKD"
     gene            6762..7553
                     /gene="folP"
                     /locus_tag="VHC05_000213"
     CDS             6762..7553
                     /gene="folP"
                     /locus_tag="VHC05_000213"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HEQ5401561.1"
                     /translation="MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQM
                     IADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARA
                     ALEAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRA
                     QAALDAGVPKNNIWIDPGFGFAKSVQQNMELLKGLDRVCQLGYPVLFGISRKRVVDAL
                     LGGNTKAKERDGATAALSAYALGKGCQIVRVHDVKANQDIVAVLS"
     gene            7569..7928
                     /gene="folB"
                     /locus_tag="VHC05_000214"
     CDS             7569..7928
                     /gene="folB"
                     /locus_tag="VHC05_000214"
                     /EC_number="4.1.2.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003058150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroneopterin aldolase"
                     /protein_id="HEQ5401562.1"
                     /translation="MDKIVLEGCRFYGYHGAFKEEQTLGQIFLVDLELSVDLQAASLS
                     DQLTDTVHYGMVFDSVRQLVEGGKFILIERLAGAICEQLFNEFPPIEAIKVAIKKENP
                     PIAGHYKAVGIELERQR"
     gene            7925..8425
                     /gene="folK"
                     /locus_tag="VHC05_000215"
     CDS             7925..8425
                     /gene="folK"
                     /locus_tag="VHC05_000215"
                     /EC_number="2.7.6.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-hydroxy-6-
                     hydroxymethyldihydropteridine diphosphokinase"
                     /protein_id="HEQ5401563.1"
                     /translation="MTIVYLSLGTNMGDRAAYLQKALEALADLPQTRLLAQSSIYETT
                     AWGKTGQADFLNMACQLDTQLTAADFLKETQAIEQSLGRVRHEKWGSRTIDIDILLFG
                     EEVYDTKELKVPHPYMTERAFVLIPLLELQPDLKLPPNHKFLRDYLAALDQSDITLFS
                     AQQTEF"
     gene            8575..9462
                     /gene="murB"
                     /locus_tag="VHC05_000216"
     CDS             8575..9462
                     /gene="murB"
                     /locus_tag="VHC05_000216"
                     /EC_number="1.3.1.98"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="HEQ5401564.1"
                     /translation="MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNHYELSRIV
                     AYANKENMPWLVLGNASNLIVRDGGIRGFVIMFDKLNAVHLNGYTLEAEAGANLIETT
                     KIAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEISHIFLSAKVLTSSGEIKTISAR
                     DMAFGYRHSAIQETGDIVISAKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSV
                     FKRPPGHFAGQLIMEANLKGHRIGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETV
                     ENHSGVRLEPEVRIIGENL"
     gene            9508..10662
                     /locus_tag="VHC05_000217"
     CDS             9508..10662
                     /locus_tag="VHC05_000217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401565.1"
                     /translation="MTKPIITFNNVSKTFEDSGTQVLKNINFDLEEGKFYTLLGASGS
                     GKSTILNIMAGLLDASSGDIYLDGERINDLPINKRDIHTVFQNYALFPHMTVFENVAF
                     ALKLKKVDKKEIAKRVKETLKMVQLEGYENRSIQKLSGGQRQRVAIARAIINQPRVVL
                     LDEPLSALDLKLRTEMQYELRELQQRLGITFVFVTHDQEEALAMSDWIFVMNEGEIVQ
                     SGTPVDIYDEPINHFVANFIGESNIINGTMIEDYLVSFNGKEFESVDGGMRPNEPVEV
                     VIRPEDLQITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMIHSTRKAIEGEVIG
                     LDFTPEDLHIMRLNETEEEFDARIEEYVEMDEPEDGLINAIEEERNEENL"
     gene            10646..11440
                     /locus_tag="VHC05_000218"
     CDS             10646..11440
                     /locus_tag="VHC05_000218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5401566.1"
                     /translation="MKKTSSLFSIPYFLWILFFVVAPVTLLFYKSFFDIEGRVTLANY
                     ETFFSSWTYLRMSVNSILYAGIITLVTLLISYPTALFLTRLKHKQLWLMLIILPTWVN
                     LLLKAYAFMGIFGQQGGINSFLTFMGIGPQQILFTDFSFIFVASYIELPFMMLPIFNA
                     LDDIDHNVINASRDLGASEFQAFSKVIFPLSLNGVRAGVQSVFIPSLSLFMLTRLIGG
                     NRVITLGTAIEQHFLTTQNWGMGSTIGVVLILTMVAIMWLTKEKSK"
     gene            11437..12213
                     /locus_tag="VHC05_000219"
     CDS             11437..12213
                     /locus_tag="VHC05_000219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5401567.1"
                     /translation="MKKFANLYLASVFVLLYIPIFYLIFYSFNKGGDMNGFTGFTLEH
                     YQTMFEDSRLMTILLQTFVLAFSSALLATIIGTFGAIFIHHVRGKYQNAMLSANNVLM
                     VSPDVMIGASFLILFTSLKFQLGMSSVLLSHIAFSIPIVVLMVLPRLKEMNQDMVNAA
                     YDLGANYFQMLKEVMLPYLTPGIIAGYFMAFTYSLDDFAVTFFLTGNGFTTLSVEIYS
                     RARQGISLDINALSTIVFFFSILLVIGYYYMSQDKEEKHA"
     gene            12206..13279
                     /locus_tag="VHC05_000220"
     CDS             12206..13279
                     /locus_tag="VHC05_000220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012766865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEQ5401568.1"
                     /translation="MRKLYSFLAGVLGVIVILTSLSFILQKKSGSGSQSDKLVIYNWG
                     DYIDPALLKKFTKETGIEVQYETFDSNEAMYTKIKQGGTTYDIAVPSDYTIDKMIKEN
                     LLNKLDKSKLVGMDNIGKEFLGKSFDPQNDYSLPYFWGTVGIVYNDQLVDKAPMHWED
                     LWRPEYKNSIMLIDGAREMLGVGLTTFGYSVNSKNLEQLQAAERKLQQLTPNVKAIVA
                     DEMKGYMIQGDAAIGITFSGEASEMLDSNEHLHYIVPSEGSNLWFDNLVLPKTMKHEK
                     EAYAFLNFINRPENAAQNAAYIGYATPNKKAKALLPDEIKNDPAFYPTDDIIKKLEVY
                     DNLGSRWLGIYNDLYLQFKMYRK"
     gene            complement(13334..13999)
                     /locus_tag="VHC05_000221"
     CDS             complement(13334..13999)
                     /locus_tag="VHC05_000221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HEQ5401569.1"
                     /translation="MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTD
                     YAIDLILLDIHITDGNGIQFLEKWRAQHIPCEVIIISAANDGNIIRDGFHLGIIDYLI
                     KPFTFERFQESIQQFVTHREHLANQQLEQAQIDQLKCLTSKKDTKNKQLLEKGLSEST
                     FQWIMENIKAFDQPFTIQELASACHLSHVSVRKYIAYLEENKQLNSQQIFTKVGRPYR
                     VYW"
     gene            complement(13980..15521)
                     /locus_tag="VHC05_000222"
     CDS             complement(13980..15521)
                     /locus_tag="VHC05_000222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEQ5401570.1"
                     /translation="MKKPLRLWASLSLILVSMIVVTTSLFYGIMLHDTHQSIKNQETH
                     LLTSTGKMLASHQAIKELLLNNQPNAKTTAYTNSIASIYNLDYVVVMNMKGIRLTHPN
                     PKNIGKPFQGGDEEAVLAGKKVISTAKGTLGKSLRYLVPVFDGDKQIGAIAVGIKLTT
                     LNDVALTSKRNYTLSLLLCLLISLLVTSFISFRLKRQLHQLEPSEIYQLFEERNAMLD
                     QIEAAVFVVDKAGILQLCNQAGQKLIARKCQLGKPTGNSFNHLFPDFPKLSLQEGHEQ
                     LFRYGEEDYLLAISPICVKNDHRGHIIFMREAVKAIDTLDQLAYTTAYASALQAQTHK
                     FMNQLHVIYGLVDIAYYDQLKIYLDSILEPENEILTSLSVLVKEPLLASFLIGEQEKY
                     QELNVHLKIDVLSEIPHSATKNQLNNGLMIYRFIHTNLLTTLRPKSLVLSIQHDQNHL
                     ISHYTLTDNWIDLERVQPIFDLPYFQQLLTDTNSQFHQHQTVTELQFSVTTPYVGGQH
                     ERFNH"
     gene            15682..17013
                     /locus_tag="VHC05_000223"
     CDS             15682..17013
                     /locus_tag="VHC05_000223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxycarboxylate transporter family protein"
                     /protein_id="HEQ5401571.1"
                     /translation="METISKKMPQKDLSEHSKAWQNRRIGSVPLPVYLVLATLILVTG
                     WLQQLPVNMLGGFAVILTLGWLLGTIGATIPGLKHFGGPAILSLLVPSILVFFNLLNP
                     NVLEATNVLMKQANFLYFYIACLVCGSILGMNRKILIQGLFRMIIPMLLGMVCAMGVG
                     TLVGVILGLDWQHTLFYVVTPVLAGGIGEGILPLSLGYSAITGVGSEQLVAQLIPATI
                     IGNFFAILCTALLNRFGEKHPSYSGQGQLVKIGHSEDMSDALKDNSGALDVKLMGAGV
                     LTACSLFIAGGLLQHLTGFPGPVLMIILAAFLKYLNVIPQETQNGAKQLYKFISSNFT
                     FPLMAGLGLLYIPLKEVVATLSWQYFIVVISVVLTVVSVGFFVSRFLNMNPVEAAIIS
                     ACQSGMGGTGDVAILSTADRMNLMPFAQVATRLGGAITVITMTAILRIIFS"
     gene            17044..18210
                     /locus_tag="VHC05_000224"
     CDS             17044..18210
                     /locus_tag="VHC05_000224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent malic enzyme"
                     /protein_id="HEQ5401572.1"
                     /translation="MKNQLGQLALEQAKTFGGKLEVQPKVDITNKHDLSIAYTPGVAG
                     VSSAIAKDKTLAYDLTTKKNTVAVISDGTAVLGLGDIGPEAAMPVMEGKAALFKAFAG
                     VDAIPIVLDTKDTEEIISIVKALAPTFGGINLEDISAPRCFEIEQRLIKECHIPVFHD
                     DQHGTAIVVLAAIFNSLKLLKKSLDEVSIVVNGGGSAGLSITRKLLAAGATKVTVVDK
                     FGIINEQEAAQLAPHHLDIAKVTNREFKSGTLEDALEGADIFIGVSAPGVLKAEWISK
                     MAARPVIFAMANPIPEIYPDEALEAGAYIVGTGRSDFPNQINNVLAFPGIFRGALDAR
                     AKTITVEMQIAAAKGIASLVPDDALSTTNIIPDAFKEGVAEIVAKSVRSVVLKS"
     gene            complement(18292..19341)
                     /locus_tag="VHC05_000225"
     CDS             complement(18292..19341)
                     /locus_tag="VHC05_000225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015632209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="HEQ5401573.1"
                     /translation="MKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHI
                     LGGDVPACKEGTILGHEGIGIVKEVGDAVTNFKIGDKVIISCVTSCHTCYYCKRGLSS
                     HCEDGGWILGHLINGTQAEYVHIPHADGSLYHAPDTIDDEALVMLSDILPTSYEIGVL
                     PSHVKPGDNVCIVGAGPVGLAALLTVQFFSPANIIMVDLSQNRLEAAKTFGATHTICS
                     GSSEEVKAIIDDITNGRGVDISMECVGYPATFDICQKIISVGGHIANVGVHGKPVDFN
                     LDELWIKNITLNTGLVNANTTEMLLNVLKTGKIDATRLITHHFKLSEVEKAYETFKHA
                     GVNNALKVIIDNDIS"
     gene            19577..20308
                     /gene="aphA"
                     /locus_tag="VHC05_000226"
     CDS             19577..20308
                     /gene="aphA"
                     /locus_tag="VHC05_000226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acid phosphatase AphA"
                     /protein_id="HEQ5401574.1"
                     /translation="MKKEFTSILFTVSFCGIIALPVEASGPKVPYTQEGITAISNQAT
                     VKLISIADIASSLEGQKPITVSFDIDDTLLFTSQYFQYGKEYITPGSFDFLHKQKFWD
                     LVAKRGDQDSIPKEYAKQLIAMHQKRGDKIVFITGRTRGSMYKKGEIDKTAKSLAKDF
                     KLDKPIAINYTGDKAVKPYQYDKTYYIKKNGSQIHYGDSDEDINAAKEAGARPIRILR
                     APNSTNLPLPKAGGYGEEVLENSAY"
     gene            20486..22018
                     /locus_tag="VHC05_000227"
     CDS             20486..22018
                     /locus_tag="VHC05_000227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ClC family H(+)/Cl(-) exchange transporter"
                     /protein_id="HEQ5401575.1"
                     /translation="MENHKNEFTFSNKSIIAYVWRGVMVGIIAGVIVSLFRLLIEVTA
                     DWVIEWYRYAHINSLLLLPILSVSLLAVLFVGFLVKSDSDIKGSGIPHVEGELKGLMS
                     PDWWSVLWKKFLGGIMAISMGFMLGREGPSIQLGAMSAKGLAKFLKSSRLEKRVLIAS
                     GAAAGLSAAFNAPIAGLLFVVEEIYHHFSRLIWITALVASLVANFISLNIFGLKPILA
                     MSEAMPFLGLNQYWLLLLLGLFLGCLGYLYEIVILNFNKLYVILGSWLHLPAYFYGII
                     MVFLILPIGYYLPQLLGGGHGLILSLSNQQLPLMTIFFYFIIRFIVSMFSYGSGLPGG
                     IFLPILTLGALAGLLFGQIASQLGLLNQSFLSLFLILGMAGYFAAISKAPLTGMILVT
                     EMVGDLKPLMAIAVVTFVSYLVMDLLNGQPIYEAMLDKMAMKHPTNLVEPTLIELTVG
                     DKIAGKYVKELKLPENVLITTQIHHQKSQVVSGNTRLLSGATIFLVVNEADTGFVREV
                     LM"
     gene            22181..22795
                     /locus_tag="VHC05_000228"
     CDS             22181..22795
                     /locus_tag="VHC05_000228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipase"
                     /protein_id="HEQ5401576.1"
                     /translation="MLEIVSEELRHYQEQKLIEYRNKNQLAPKGGIVFAGDSLIEFFP
                     LKKAFGSCLPIINRGIAGIDSQWLLRHFSVQITDLEPKHIFLLIGCNDIGLGYDKCHI
                     VKTIVELISQIRSHCVYSQIYLLSLLPVSNNPRYQKTVKIRTNAMIDAINKDLAMIPT
                     IEFINLNTCLKDEKGGLSDENTLDGLHLNFPAYAKLAEIIQSYI"
     gene            22954..24102
                     /locus_tag="VHC05_000229"
     CDS             22954..24102
                     /locus_tag="VHC05_000229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HEQ5401577.1"
                     /translation="MIIKGVTMKFEKKQVFYLVLTFILCYGILANWRNGTAIVTTIYK
                     TSLPFFYGAAGAYIVNIVMSAYEKVYVYIFKDWSHVLKVKRGICLLLAYLTFFILITW
                     IISIVIPDLITSISTLTKFDTITIQEVVNNLEHNKLLARTIQYIGGDGKLTETIANYS
                     QQLLKQFLTVLTNILTSVTVIASAIINLFISFVFSLYVLASKEDLCRQGNTLVDTYTG
                     KYAKRIHYLLELLHQRFHGFFVSQTLEAMILGSLTASGMFILRLPFAGTIGVLVAFTA
                     LIPVIGASIGAAIGFILIMTQSMSQAIIFIIFLIILQQIEGNFIYPKVVGGSIGLPAM
                     WVLMAITIGASLKGIVGMIIAVPLAATLYQVIKDNIQKRQAIQKKQVS"
     gene            24151..24831
                     /gene="radC"
                     /locus_tag="VHC05_000230"
     CDS             24151..24831
                     /gene="radC"
                     /locus_tag="VHC05_000230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadC"
                     /protein_id="HEQ5401578.1"
                     /translation="MYSIKCDDNKAMPRERLMRLGAESLSNQELLAILLRTGNKEKHV
                     LELSSYLLSHLDSLADFKKMSLQELQHLAGIGKVKAIEIKAMIELVSRILATDKTLTD
                     SVLTSVQVAEKMMAALGDKKQEHLVVLYLDNQNRIIEEKTIFIGTVRRSLAEPREILY
                     YACKNMATSLIVIHNHPSGNIEPSSNDYCFTEKIKRSCEDLGIICLDHIIVSYKDYYS
                     FREKSTLF"
     gene            complement(24833..25528)
                     /locus_tag="VHC05_000231"
     CDS             complement(24833..25528)
                     /locus_tag="VHC05_000231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HEQ5401579.1"
                     /translation="MTKPIIGITANQRLNMALDNLPWSYAPTGFVQAVTQSGGLPLLL
                     PIGDEAAAKTYVSMVDKIILIGGQNVDPKYYQEEKAAFDDDFSPERDTFELAIIKEAI
                     TLKKPILGICRGTQLMNVALGGNLNQHIDSHWQEAPSDFLSHEMIIEPDSILYPIYGH
                     KTLINSFHRQSLKTVAKDLKVIARDPRDGTIEAVISTNDAIPFLGVQWHPELLQGVRD
                     EDLQLFRLFVNDF"
     gene            complement(25538..26182)
                     /locus_tag="VHC05_000232"
     CDS             complement(25538..26182)
                     /locus_tag="VHC05_000232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="HEQ5401580.1"
                     /translation="MVIDKSIPKATAKRLSLYYRIFKRFHADQVEKASSKQIADAMGI
                     DSATVRRDFSYFGELGRRGFGYDVTKLMNFFADLLNDHSTTNVILVGCGNIGRALLHY
                     RFHDRNKMQIAMGFDTDDNALVGTKTADNIPVHGISSVKERIANTDIETAILTVPSIH
                     AQKVTDQLIEAGIKGILSFAPVHLQVPKGVIVQSVDLTSELQTLLYFMNQNHLD"
     gene            complement(26433..26780)
                     /locus_tag="VHC05_000233"
     CDS             complement(26433..26780)
                     /locus_tag="VHC05_000233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1831 domain-containing protein"
                     /protein_id="HEQ5401581.1"
                     /translation="MAFEKEIKLKDCKYLYTISPNIKKYTLRDTTFSQTKVGHYQLIR
                     LLETIPNSGDGFPLKITINKELTGFKLAITDQSGLRLVNIFKTKDNQILQDKFYFLMD
                     SLVEREIFSKTVV"
     gene            complement(26770..27897)
                     /locus_tag="VHC05_000234"
     CDS             complement(26770..27897)
                     /locus_tag="VHC05_000234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEQ5401582.1"
                     /translation="MTYFDNAATTPLSPNVIRAMTAAMQDNFGNPSSIHFYGRRANKI
                     LRECRQAIARNLGASEQQIIVTSGGTESNNMAIKGYALAHQAKGKHLITTTIEHHSVL
                     HTMAYLEERFGFEVTYLPCQNGQINLSDLKQALRDDTILVSIMYANNETGDLLPIKDI
                     GNLLKDHQAAFHVDAVQAVGKLKIIPSELGIDFLSASAHKFHGPKGCGFLYSNGQPID
                     PLLHGGDQEGKRRASTENMLGIIGMAQALTDAMTCLDQSTDHIISLRHHLISLLEGLP
                     YYINQGTHYLPHVLNIGFLGYQNTILLTQLDLAGIAVSTGSACTAGAVNPSHVLAAYY
                     GDDSSRLKESIRISFSDQNSIEDVNQLAQTLKNILGGTDGF"
     gene            complement(27894..28874)
                     /locus_tag="VHC05_000235"
     CDS             complement(27894..28874)
                     /locus_tag="VHC05_000235"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HEQ5401583.1"
                     /translation="MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDG
                     EIMINIEETVRGDDIYIIQSTSFPVNDNLWELLIMIDACKRASANTVNIVLPYFGYSR
                     QDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAER
                     YSKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSG
                     KKAILIDDILNTGKTFAEAAKILERSGATDTYAVASHGLFAGGAADVLETALIKEIIV
                     TDSVKTKNRVPENVTYLSASDLIAEAIIRIHERRPLSPLFSYQPKGKNNA"
     gene            complement(29014..29592)
                     /locus_tag="VHC05_000236"
     CDS             complement(29014..29592)
                     /locus_tag="VHC05_000236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CYTH domain-containing protein"
                     /protein_id="HEQ5401584.1"
                     /translation="MTNLEIEYKTLLTKNEYNRLLFQMKHVTPVTQTNYYIDTKAFDL
                     KANKMSLRIRTFVNSAELTLKVPEKVGNREYNVPLFLEQAKDMIKHGNLPESTALDII
                     ISKGIKPSALVTFGNLTTVRRETVIPIGKLALDYNLYANTKDYELELEVSDALQGKID
                     FDSFLSEHHITFKYAKSKVARCINTLKKFNDK"
     gene            29680..30351
                     /locus_tag="VHC05_000237"
     CDS             29680..30351
                     /locus_tag="VHC05_000237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017771989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="HEQ5401585.1"
                     /translation="MTLDWEEFLDPYIQTVGELKIKLRGIRKQYRKQNRYSPIEFVTG
                     RVKSIESIKEKMILRGVIEENIAQDIQDIAGLRIMVQFVDDVEEVLALLRQRQDMTIV
                     YERDYIRNMKSSGYRSYHVVVEYPVDTIEGQKKVLAEIQIRTLAMNFWATIEHSLNYK
                     YGGDFPEEIKKRLEVTAKIALELDEEMRKIREDIREAQLLFDPVTRNLSDGVGNSDDT
                     DELYR"
     gene            30326..31162
                     /locus_tag="VHC05_000238"
     CDS             30326..31162
                     /locus_tag="VHC05_000238"
                     /EC_number="2.7.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD kinase"
                     /protein_id="HEQ5401586.1"
                     /translation="MTQMNYTGKVKRVAIIANGKYQSKRVASKLFSVFKDDPDFYLSK
                     KNPDIVISIGGDGMLLSAFHMYEKELDKVRFVGIHTGHLGFYTDYRDFEVDKLIDNLR
                     KDKGEQISYPILKVAITLDDGRVVKARALNEATVKRIEKTMVADVIINHVKFESFRGD
                     GISVSTPTGSTAYNKSLGGAVLHPTIEALQLTEISSLNNRVFRTLGSSIIIPKKDKIE
                     LVPKRLGIYTISIDNKTYQLKNVTKVEYFIDDEKIHFVSSPSHTSFWERVKDAFIGEI
                     DS"
     gene            31159..32064
                     /locus_tag="VHC05_000239"
     CDS             31159..32064
                     /locus_tag="VHC05_000239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEQ5401587.1"
                     /translation="MRFEFVADKRIKVKTLLKSHDVSKGLLAKIKYKGGNILVNGIEQ
                     NAIYLLQVGDVVTIDIPNEEPFEKLEAIPFDLDIVHEDDHFLVINKPIGFASIPSAIH
                     SNTIANFIKAYYVDNHYLDQQVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQTRSIE
                     KRYFALVSGNGTLPDEGDIIAPIGRSKDSIITRAVDPMGKYAKTSYKVVARYSENVHL
                     VDIKLHTGRTHQIRVHFAHIGFPLLGDDLYGGRLDLGITRQALHCHYLNFKDPFTESD
                     CSYAIHLTDDFDSVIIGLQKKDRGY"
     gene            32068..33063
                     /gene="pta"
                     /locus_tag="VHC05_000240"
     CDS             32068..33063
                     /gene="pta"
                     /locus_tag="VHC05_000240"
                     /EC_number="2.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acetyltransferase"
                     /protein_id="HEQ5401588.1"
                     /translation="MSIRSLFGGLREKILGKNMKIVFPEGNDERVVRAAARLKFEGLL
                     EPIILGQSEEVRNLLTKLGFADQDYTIINPNEYADFDKMKEAFVDIRKGKATLEDADK
                     MLRDVNYFGVMLVKMGLADGMVSGAIHSTADTVRPALQIIKTKPGISRTSGVFLMNRE
                     NTSERYVFADCAINIDPTAQELAEIAVNTAETAKIFDIDPKIAMLSFSTKGSGKAPQV
                     DKVREATEIAKGLNPDLALDGELQFDAAFVPETAAIKAPDSAVAGQANTFIFPDLQSG
                     NIGYKIAQRLGMFDAIGPILQGLNKPVNDLSRGSSAEDIYKLAIITAAQAIESQG"
     gene            33190..33945
                     /locus_tag="VHC05_000241"
     CDS             33190..33945
                     /locus_tag="VHC05_000241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HEQ5401589.1"
                     /translation="MGNIALVTGASAGFGRAIVEHLIADGIKVIGASRRLEKLKALET
                     SFGSDNFYPLQMDVTDTKAIDDALTSLPNQWQDITILVNNAGLALGLDKAYEADFENW
                     MTMINTNIVGLIYLTRQLLPHMVSKDDGIIINLGSTAGTIPYPGANIYGASKAFVKQF
                     SLNLRADLAGSHIRVTNIEPGLCEGTEFSKVRFNGDEARVKAIYQGAHAIQPQDIAST
                     VSWVIHQPPHVNVNRIELMPVSQSYGPQPVTRD"
     gene            complement(34138..34827)
                     /locus_tag="VHC05_000242"
     CDS             complement(34138..34827)
                     /locus_tag="VHC05_000242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug transporter"
                     /protein_id="HEQ5401590.1"
                     /translation="MKNAISILALLTPENQLEDTFIRELSHHFSHLFEVTILTSKANI
                     ESNQLSTFQGIFSFHEHDIDLPTLYFKTSQHGQGFLVTESVFDQATAVLSLSQYLTRF
                     YQKFDRHFLEYLPLQARLSDAKGNILVDNHAFNGSFLPTTDNEIEDWILAELRLSDNP
                     CKTFLLPSGSLDHIYMQHYQALKNPQGQLVGVLDTVQDIKPLLSQYLEETGQAIVGWS
                     DVTSGPSILDH"
     gene            35250..35978
                     /locus_tag="VHC05_000243"
     CDS             35250..35978
                     /locus_tag="VHC05_000243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401591.1"
                     /translation="MIRFNNVSKTFGQTKVLQEQTFQINDREFFVLVGPSGSGKTTLL
                     KMINCLIEPSSGDILLNNVPQKELDLREMRLSIGYVLQQIALFPNLTVAENIAIIPDM
                     KQWSAEEIRQKTEELLDKVGLPAKDYLDRYPSDLSGGEQQRIGIVRAIISHPKILLMD
                     EPFSALDPISRKQLQELMLSLHKEFDMTIVFVTHDIDEAIKLGDRVAILNEGEIVQLD
                     RPEMIKTHPANAFVANLFGGDEHA"
     gene            35971..37497
                     /locus_tag="VHC05_000244"
     CDS             35971..37497
                     /locus_tag="VHC05_000244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014411840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease/substrate-binding
                     protein"
                     /protein_id="HEQ5401592.1"
                     /translation="MPSLFVTFQNRFNEWLAALGEHLQISLLSLMIALLIGVPLAALL
                     SRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTLPAVTALVIYAIFPILQNTIT
                     GLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIG
                     AGGLGSFILLGIDRNNANLILIGAISSALLAIIFNSLLQYLEKASLRRIIISFGITLL
                     ALLASYTPMALSQFSKGKDTVVIAGKLGAEPDILINLYKELIEDQSDISVELKSNFGK
                     TSFLYEALKSGDIDIYPEFTGTITSSLLRDKPPLSNDPKQVYEDAKKGIAKQDKLTLL
                     KPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQY
                     GLQLSVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPL
                     MKTSLLTKHPELKGILNQLAGKITEKEMQDMNYEVSVKGADANKVARDYLLKTGLIQK
                     "
     gene            37775..38758
                     /gene="guaC"
                     /locus_tag="VHC05_000245"
     CDS             37775..38758
                     /gene="guaC"
                     /locus_tag="VHC05_000245"
                     /EC_number="1.7.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007891361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GMP reductase"
                     /protein_id="HEQ5401593.1"
                     /translation="MFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVI
                     PANMQTIIDETIAEQLAKEGYFYIMHRFDEDSRKPFIKRMHEQGLIASISVGVKAYEY
                     EFVTSLKEDTPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELEN
                     AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIA
                     KSIRFGASMVMIGSLFAGHIESPGKTVEVNGETFKEYYGSASAYQKGEHKNVEGKKIL
                     LPTKGHLSDTLTEMQQDLQSSISYAGGKDLDSLRHVDYVIVKNSIWNGDSI"
     regulatory      38881..38976
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            39063..39644
                     /locus_tag="VHC05_000246"
     CDS             39063..39644
                     /locus_tag="VHC05_000246"
                     /EC_number="2.4.2.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine phosphoribosyltransferase"
                     /protein_id="HEQ5401594.1"
                     /translation="MQLLEERILTDGNILGENILKVDNFLTHQVDYRLMKAIGKVFAQ
                     KYAEAGITKVVTIEASGIAPAVYAAEAMDVPMIFAKKHKNITMTEGILTAEVYSFTKQ
                     VTSTVSIAGKFLSKEDKVLIIDDFLANGQAAKGLIEIIGQAGAQVVGVGIVIEKSFQD
                     GRRLIEDMGIEVTSLARIKNFENGNLNFLEADA"
     gene            39644..40927
                     /locus_tag="VHC05_000247"
     CDS             39644..40927
                     /locus_tag="VHC05_000247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HEQ5401595.1"
                     /translation="MTHSTKQEHSHSQSAVLGLQHVLSMYAGSILVPIMIAGALGYSA
                     RELTYLISTDIFMCGVATFLQLKLTKHTGVGLPVVLGCAFQSVAPLSIIGAQQGSSAM
                     FGALIASGIYVILVAGIFSKIARFFPPIVTGSVITVIGLSLVGVAMGNMGDNVKEPTA
                     QSVMLSLLTIVIILLVQKFTKGFVKSISILIGLVAGTLVSAMMGLVDTTPVVEASWIH
                     VPTPFYFGMPTFDITSIVMMCIIATVSMVESTGVYLALSDLTNDQLDEKRLRNGYRSE
                     GIAVFLGGLFNTFPYTGFSQNVGLVQISGIKTRRPIYYAAGILVVIGLLPKFGAMAQM
                     IPSPVLGGAMLVLFGMVALQGMQMLNRVDFQKNEYNFIIAAVSISAGLGFNGTNLFAS
                     LPETAQMFLTNGIVIATLTSVVLNLVLNGKDKQDE"
     gene            complement(40991..41929)
                     /locus_tag="VHC05_000248"
     CDS             complement(40991..41929)
                     /locus_tag="VHC05_000248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD:protein FMN transferase"
                     /protein_id="HEQ5401596.1"
                     /translation="MFVTQQLKLMGTVIDIQIKSDKACQQLSRVIDLLYTYKNRFSAN
                     DSNSELMAINQAAGVKPVSVHSDLFNLIQIGKAHSLSTPSNLNIAIGPLVQAWRIGFE
                     DAIVPSHNLISQQLALTDPRQVLIDDKKQTVFLQQVGMALDLGALAKGYITDKIMAYL
                     IEDGIDSALINLGGNALVHGPNPKSPDKTFRIGVQKPDAKRGQHLGVIKVNNHSVVTS
                     GIYERQFTAKGKQYHHILDRQTGYPIETDMLSLTVMASSSLDCDIWATRLFGLDSSMI
                     ITLLNTFDNIEGLLVTRKHHVLMSNGLRHYFQPYYH"
     gene            complement(41982..42167)
                     /locus_tag="VHC05_000249"
     CDS             complement(41982..42167)
                     /locus_tag="VHC05_000249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-oxalocrotonate tautomerase"
                     /protein_id="HEQ5401597.1"
                     /translation="MPFVTIDLFEGRSQEQKNQLAREVTEVVSRIAKAPKENIHVFIN
                     DMPEGTYYPQGEMKQKS"
     gene            42305..42874
                     /locus_tag="VHC05_000250"
     CDS             42305..42874
                     /locus_tag="VHC05_000250"
                     /EC_number="2.7.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000068112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidine kinase"
                     /protein_id="HEQ5401598.1"
                     /translation="MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRD
                     GFGIVSSRIGMRREAIPISNDMDIFTFIAQLEEKPYCVLIDESQFLSKQNVYDLARVV
                     DELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRTENGK
                     PVYEGDQIQIGGNETYIPVCRKHYFNPEI"
     gene            42909..43988
                     /gene="prfA"
                     /locus_tag="VHC05_000251"
     CDS             42909..43988
                     /gene="prfA"
                     /locus_tag="VHC05_000251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 1"
                     /protein_id="HEQ5401599.1"
                     /translation="MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTR
                     ETVTAYREYKQVIQTISDAEEMIKDASGDPELEEMAKEELKESKAAKEEYEEKLKILL
                     LPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGG
                     IKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDI
                     DQKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIR
                     ARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTIL
                     SGKMDEVIDALVMYDQTKKLESLNN"
     gene            43988..44827
                     /gene="prmC"
                     /locus_tag="VHC05_000252"
     CDS             43988..44827
                     /gene="prmC"
                     /locus_tag="VHC05_000252"
                     /EC_number="2.1.1.297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="HEQ5401600.1"
                     /translation="MNYATLIRTYEDKLEQIDEDRENLAYVFREIKEWSSLDMLIHQN
                     QAVTPEDAVLLEHIFCSLSQHLSPQYITGNAYFRDLKLAVDKRVLIPRPETEELVDMI
                     LAENLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLDI
                     TFIESDVFSLISGTFDIIVSNPPYISYEDKEEVSLNVLQSEPHLALFAKENGYAIYRK
                     IIEQADNYLTKEGKLYFEIGYKQAEGIKDMLQAYFPQRHIRVVTDIFGKERMVVVDYG
                     VSS"
     gene            44811..45401
                     /locus_tag="VHC05_000253"
     CDS             44811..45401
                     /locus_tag="VHC05_000253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonylcarbamoyl-AMP synthase"
                     /protein_id="HEQ5401601.1"
                     /translation="MEYLASIIELGDALVLPTETVYGLFAKALDEKAVNAVYDLKQRP
                     RDKAMNLNVADFNSILAFSKEQPRYLKKLYQAFLPGPLTIILKANDQVPYWINSGLST
                     VGFRLPSHPITAALIQKTGPLIGPSANLSGKASGRVFDHIMQDFDFQVFGYADDPFLT
                     GKDSTILDLSGECAVILRQGAITKEELLANVPELRF"
     gene            45419..45870
                     /locus_tag="VHC05_000254"
                     /pseudo
     CDS             45419..45870
                     /locus_tag="VHC05_000254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528633.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            45860..47116
                     /locus_tag="VHC05_000255"
     CDS             45860..47116
                     /locus_tag="VHC05_000255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003053314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HEQ5401602.1"
                     /translation="MIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVM
                     AAQGSVLTNKYAEGYPGNRYYGGTECVDIVETLAIERAKKLFGAAFANVQAHSGSQAN
                     AAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTETLNYEAIL
                     EQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPV
                     PYAHIVTSTTHKTLRGPRGGLILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFK
                     EALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHVFLVDVTKVIANGKLAQ
                     NLLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMSVKESQTIARLIIKALVN
                     HDQETILEEVRQEVRQLTDAFPLYKK"
     gene            47123..48100
                     /locus_tag="VHC05_000256"
     CDS             47123..48100
                     /locus_tag="VHC05_000256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HEQ5401603.1"
                     /translation="MLDSYIKRIVIHQFSPNDTELLLSDRLVSITPRIDEYFRKKLAK
                     VFSDEAKRGQFEANNTFFTTIGDDLLETSVTIAQLWKEAFVISEDQKTNDLVFVQFDK
                     DGEPFFAFLRIALKEQFAHLSDNYEHPFTVTQNNLPSPTQTPDEALVINLKSGQYYLI
                     EKRVKHNGSFANYFSEHLLKVTPEQSVKKSIKMIEQTAQKIAEHFNQDDFTFQSKMKS
                     TLFKQLEADDVLSPEKLADQLFDDNLTARLTFVDQVKEVIPEPIKISDIDHSRQIKKL
                     ENQKLSLSNGIELTVPNAIYQDAEAVEFLLNDDGTYSILIKNIEDIKTK"
     gene            48101..48712
                     /locus_tag="VHC05_000257"
     CDS             48101..48712
                     /locus_tag="VHC05_000257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysozyme family protein"
                     /protein_id="HEQ5401604.1"
                     /translation="MFRLLKRACSFLLLFVIYQSFVIHHNVQRVLVYKPMVEKTLAEN
                     DTKANVDLVLAMIYTETKGGEADVMQSSESSSGQKNSITDSQASIEHGVNLLSHNLAL
                     AEEAGVDSWTAVQAYNFGTAYIDYIAKHGGQNTVDLATTYSKTVVAPSLGNTSGQTYF
                     YYHPLALISGGKLYKNGGNIYYSREVHFNLYLIELMSLFRKLS"
     gene            48709..50433
                     /locus_tag="VHC05_000258"
     CDS             48709..50433
                     /locus_tag="VHC05_000258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401605.1"
                     /translation="MKRLRPYVKGYLKESILGPLFKLLEALFELLVPLLIANMIDISI
                     SQHNSQGILRVVLTLFGLATIGLLLSVTAQYFSSKAAVGFTRQMTDDLFKKIMFLSKE
                     DQDHLGYASLLSRLTSDSFQIQTGINQFLRLFLRAPIIVCGAMVMAYWISPSLTLWFV
                     MMVIVLLTLVFVMSHLLDPLYLLIRRETDHLVRLTSQQLQGIRVIKAFNQTQKELQAF
                     KQQNMLLSRHQYQAATLANVLNPMTFLVVNLTLLILIWQGSWQVAHRSLSQGMLVALI
                     NYLLQILAELLKMTMLMGTINQSVTAAKRINQVFVLADEAPLPLLKDGPISTHLLTIR
                     HLTFTYPGAAEPSLYDIQLSADQGEWIGIIGGTGAGKTTLIDLICQTYSQYSGEISLN
                     WQGEVPKTLTEWRNVIALVPQKAQLFKGTIRSNLLLGQSIPISDEELWRALELAQAKE
                     FVAALPEQLEAPVEAFGRHFSGGQRQRLAIARALLKPKPILILDDASSALDNETRGRL
                     FKALKEELSDVLVILVTQSIKNLQFADKILVLEQGHQLDFASHDQLKVSNALYQEMLA
                     LYVKGEQK"
     gene            50430..52157
                     /locus_tag="VHC05_000259"
     CDS             50430..52157
                     /locus_tag="VHC05_000259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401606.1"
                     /translation="MIKTDHHLLKRMLQDLLKKPLPVCILVIASFVQVGLSVYLPVLI
                     GKAVDMSLSVNSWQTLKWLLGQMLVVIVVNTLIQWVMPLVYSRLLYQYSQQLKDKLLE
                     KIHRLPFAYLDRQTIGDLVSRVITDTEQLINGLQMVFNQFILGLLTILCTIIAMAQID
                     WLMLILVLVLTPSSLFLARFIAQKSFHYAQAQTKSRGNLAQFTEEILRQEGLVQLFNA
                     QEQSICDYHVLNKTYCEASQKAIFYASTVNPATRFINSVIYALLAGLGAVRIMAGLFS
                     VGQLTTFLNVVVQYTKPFNDISSVLAEIQSSLACAQRLYDLLDIEIKEQEHFLTFKAS
                     AVKGQIDFEEVSFSYQKDRPLLKDINFSVPAGSKVAIVGPTGAGKSTLINLLMRFYEL
                     DAGSIKLDKVPIKCYAKEELRSITGMVLQETWLKDATVHELIAYGSEEASRDEVVAAA
                     KAAHAHFFIMQLPKTYDTYLSASDDALSQGQLQLLAIARMFLKKPKVLILDEATSSID
                     IRTEAVIQEALKELMRGRTSFIIAHHLSTIQSADLILVMDQGRLVEWGTHASLMSKNG
                     CYARLQKIE"
     gene            52399..53769
                     /locus_tag="VHC05_000260"
     CDS             52399..53769
                     /locus_tag="VHC05_000260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HEQ5401607.1"
                     /translation="MSKIVVVGANHAGTACIKTMLTNYGDANEIVVFDQNSNISFLGC
                     GMALWIGEQIAGPEGLFYSDKEELESLGAKVYMESPVQSIDYDAKTVTALVDGKNHVE
                     TYDKLIFATGSQPILPPIKGAEIKEGSLEFEATLENLQFVKLYQNSADVIAKLENKDI
                     KRVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQ
                     LAFGETVKEVAGNGKVEKIITDKNEYDVDMVILAVGFRPNTTLGNGKIELFRNGAFLV
                     NKRQETSIPGVYAIGDCATIYDNATRDTNYIALASNAVRTGIVAAHNACGTDLEGIGV
                     QGSNGISIYGLHMVSTGLTLEKAKRLGFDAAVTEYTDNQKPEFIEHGNFPVTIKIVYD
                     KDSRRILGAQMAAREDVSMGIHMFSLAIQEGVTIEKLALTDIFFLPHFNKPYNYITMA
                     ALGAKD"
     gene            complement(53928..54911)
                     /locus_tag="VHC05_000261"
     CDS             complement(53928..54911)
                     /locus_tag="VHC05_000261"
                     /EC_number="1.1.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate dehydrogenase"
                     /protein_id="HEQ5401608.1"
                     /translation="MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEK
                     TQGDAEDLSHALAFTSPKKIYAADYSDCHDADLVVLTAGAPQKPGETRLDLVEKNLRI
                     NKEVVTQIVASGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQAL
                     AAKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDIDEQGLVDLFIS
                     VRDAAYSIINKKGATFYGIAVALARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQ
                     PAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFAKEEFASAAKN"
     gene            55102..57588
                     /gene="gyrA"
                     /locus_tag="VHC05_000262"
     CDS             55102..57588
                     /gene="gyrA"
                     /locus_tag="VHC05_000262"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="HEQ5401609.1"
                     /translation="MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHR
                     RILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVD
                     GHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPAR
                     FPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTG
                     ALVMGRSGIHRAYDTGKGSIVLRSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVR
                     LAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKLTSLQTNFSFNMLAI
                     ENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIA
                     IIRNSETDVIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIAD
                     LSDILAKPERIITIIKEEMDEIKRKYANPRRTELMVGEVLSLEDEDLIEEEDVLITLS
                     NKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELVSTSTHDTLLFFTNFGRVYRL
                     KAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTE
                     VSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRS
                     ATGVRGVKLREDDRVVGASRIRDNQEVLVITENGFGKRTSATDYPTKGRGGKGIKTAN
                     ITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKI
                     VTFTLVQPEDSSIAEINTDRENSISKNKDN"
     gene            57608..58357
                     /locus_tag="VHC05_000263"
     CDS             57608..58357
                     /locus_tag="VHC05_000263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sortase"
                     /protein_id="HEQ5401610.1"
                     /translation="MVKKQKRRKIKSMSWARKLLIAVLLILGLALLFNKPIRNTLIAR
                     NSNKYQVTKVSKKQIKKNKEAKSTFDFQAVEPVSTESVLQAQMAAQQLPVIGGIAIPE
                     LGINLPIFKGLGNTELIYGAGTMKEEQVMGGENNYSLASHHIFGITGSSQMLFSPLER
                     AQNGMSIYLTDKEKIYEYIIKDVFTVAPERVDVIDDTAGLKEVTLVTCTDIEATERII
                     VKGELKTEYDFDKAPADVLKAFNHSYNQVST"
     gene            58440..58853
                     /locus_tag="VHC05_000264"
     CDS             58440..58853
                     /locus_tag="VHC05_000264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEQ5401611.1"
                     /translation="MKLNAIHHVAIIVSDYNLSKNFYVNKLGFEIIRENYRPDRHDYK
                     LDLSCGRIELEIFGKVTSDPYYQAPPKRVSQPEFKSEACGLRHLAFRVTNIESYVDDL
                     KNLGIPVEPIRHDDYTGEKMTFFFDPDGLPLELHE"
BASE COUNT        18213 a        10052 c        12200 g        18583 t
ORIGIN      
        1 aaaatgacta taaaatttca atggattact agcttatatt taatagtctt gtccaaatag
       61 gacaattaaa cattttttaa tcaaatctcc tttatactga tattaggaga atgttagatg
      121 tatccgcgta ttaggaattt gagagaagat aacgatttca ctcaaaagtt tgttgcaaat
      181 ttactttcct tctctcatgc aaattatgca aaaattgaga gaggagaggt tgccttaatg
      241 gcagatgttc ttgtgcagtt ttctaaactc tataacgtca gtattgatta tttattaggg
      301 caaacagatt atccgtatcg ttttcataat aaataaaagt ctcgccttga tttgttcatt
      361 gacaactgaa taaaccgagg tgggactttc ttgtttgtcg agcaatttag tgagatacgc
      421 cgtgatagga gcgataatta ttagctataa aatagagtgg ttctctatct gccatgacca
      481 caaataggga caatgatact tctgaacgtt caggctgcca gcgtaaaagg ccagtgggtg
      541 agattcccat gagtgattta accagtcata cccacggagg ttgcaatttt tttgaaagga
      601 gtggaggtgt gaaaatagta acatataaaa agcttgatga atattggttt tctcgaacat
      661 actgcaagag atattattag agaagcaaaa agaatagcta taaaaaagtt tgaagaagct
      721 cgcgaaattg accaaaatgc ggtacaatta agtaaatcgc cctttgacaa tagaagactt
      781 ggtattgctc ctaaagatat tgtagaagag ttaataggta ttctactctc tgaagaaagt
      841 ttagaaagtg agaattaaag atgactataa aaaatcaaaa aaagtacaaa ggtgtttatt
      901 gtgataagaa tggtaagata ttttatcaag ctgatcttgg tgtagatcca gtaacaggta
      961 aacgagttca aaagaaagcc agaaagaatt agtatggaga gccatttggc acaatgaaag
     1021 aagcgtatga tgaactggtt cggattaggt atgggtttag taataatctt agtattgaaa
     1081 atgacaatat atcgtttgaa aactatatga atactatatg aatactattt acctaagagc
     1141 atataagcaa aaggttcagg ctgtaactta tgaaatagcc ttaccacatc ataagttatt
     1201 tattcagtat tttggttcta aacttttaaa gggaataaca gcttgagatt gtgaatcttt
     1261 tagtttacat attattgaaa attatgcaaa gaatttatgg tcgcgattca aagcttgcat
     1321 ggggtatgct gaaaggttag actatatttc aaaagtgccg tgtaaggctt tggataatcc
     1381 taaagggaaa catcccgata ctccattttg gacttatatt gagtttcaga attttataaa
     1441 atcgtttgat ttgcaagatt atgaagagct acaaagattt acaactattt ggctatatta
     1501 tatgacaggt gttcgtgtaa gtgaaggttt atcattatga tgggaagata tcgatttcga
     1561 acaaaaattt ttgaaagttc atacaacctt ggaaaaggat gaaaatggaa attggtatcg
     1621 taaagatcaa acaaaaacgc cagcaggaga acgtcttatt gagttagatg atgtgacaat
     1681 agtagtattg gaaaattgga gaagaaatca agtagtcaat actgacacag atttcattat
     1741 ttcacggttt ggtgaaccat tttgtaaatc aacgatttgt cgagttatta agcacaaagc
     1801 tcaagaagta ggagtaccag tgataacggg aaaagtcttg cgacatagtc atgcttccta
     1861 tcttattaat gttttgaaaa aagacattct gtacgttgca aagtgtatgg gacatgctga
     1921 taagtctaca actttgaata catatagtca ctggtttaat gcattagata aaacagtatc
     1981 tgaagaaata acccaaaatg taataagttc aggattagat tccattttat accaaaattc
     2041 ctgccaaaca actaattgat ataacgaagc ttattatatc gcccatataa caggatgtgt
     2101 tattgtcaca gggtacttgc tttatgagct tgtttaagct actaaaggtg tgtgccacta
     2161 tacttccttc caaatttctg agaatttttg ttataatagt aactatgaaa gatataatga
     2221 taaaaaggtg ggttatcctt ttttttatgg tattaacttg ttcagggttt ggtaaaacag
     2281 ttctcgcagc tgattttcaa gtgggagcag aacatgcgat tgtcgtagag gcagactctg
     2341 ggagagttct gtatgagaaa gacgctaaga cgccagatgc tattgcctct ttgaccaaat
     2401 tggtgacggc ttatctggtt ttagataagg ttaaatcagg ccagctgcaa ttatcagatc
     2461 aagttaatct ctcagattat gcctttgagt taacaaaaga taggtcttta agtaatgtac
     2521 cttttgacaa aaaaacttat tcagttcaag acctgttgac agctactttg gtagcaagct
     2581 caaatagcgc tgctattgcg ttagccgaaa aagtggcggg ttcagagctt cattttgtaa
     2641 atcaaatgag agaacagcta tctcattggg ggattacttc tggtaaaatc ctcaacgcct
     2701 caggtctgcc aaatgaggtg ttaaaggata atcgttatcc tggttctgcg ttggaagaag
     2761 aaaatacctt gagtgctcaa gatgttgcag ttgtgacgat gcatttgtta gaagattttc
     2821 ctgagatttt agagatcacc aaacaaacag aagttaattt tgctggcaat tctattaaaa
     2881 gttttaatca actcttacca ggtatggcta agggtagagc aggagtggat ggtttaaaga
     2941 ctgggacaac agacttggca ggtcattgtc ttgtggtaac ttctattgaa aatggtatgc
     3001 gagtgattac cgttattcta aatgccgatg gatctgataa aaaccaaaac acgcggtttg
     3061 agcaagcaaa tcgtttgttg gactatgtgg ctagaactta ttgtcgtcgt aagattctta
     3121 aaaaaggaag tcttgtctcg gagcggtcgc tccctattca agatggccaa gtaaaagaac
     3181 taccggtatc tgttgccgaa gatgtaacca tcattttgca acagggtgaa caagttccca
     3241 aacctaaaca atttatgata tcagagactt ctttactagc accgattact aaaggtgaag
     3301 tggttgctta tttgacgtct ccaagaataa cagatcagtc agtgaggtat ttaaaggaac
     3361 ctaagcgtat tcctcttaaa gctagccaat ctcttaaaaa agcctctgac ttacagctgt
     3421 ggtggcgaga ttttcttgaa aaaagacgtt aaagataaga ataaaataat tttaaaacaa
     3481 tcaaaaaaag acagttatga aagaattttt tcataactgt ctttttagtt tacagtgagt
     3541 atgatttgga atgataaaaa aattgatgtt atggttccat tgtttgtaaa agattttccg
     3601 gactcatgtt tgggaggata cgaatcctgt taagagaaag aagcccatta gccgcgctag
     3661 ctattccttc gttagtggta acacctaatt tatagttaag tctagctgca atttgtaagg
     3721 tagtgtcatt atatctacca gatggataag caatggcaat agtgttttgg tttaattgct
     3781 tatcaagata gtcctttgaa tctttcattt cagttgtttg aacatcagga ctagcctgct
     3841 ctagatcagg atgattcact gtatgatctt ggaaagacat accgaattgt ttcatttctt
     3901 tcatctgctt aagagtcaga ttggcagcgc ttcccatttc ggttagtcct gtaataacat
     3961 tattggtggc tttagcatca tattttttta agattgggta agcaacgttg tagaaatcaa
     4021 tcatactgtc atcaaatgtt agccatacaa cttttttagc aggcaattca ttatttgaaa
     4081 gagcgcggta gacctcttca ggactcaaaa aatagtagcc ctcgtctttc attttttgaa
     4141 gttgttgatc aaagagatct gggttgacaa tcaaattagc attggccgtc tcttcagggg
     4201 acattacatg aatagcatga tacattaaaa ttgggatctt gacaggtgtt tcttgcttgg
     4261 tccaagttaa tttagaatgg gccttttttt gagattttga ggaatcgaaa tgagtcttct
     4321 taagttttgt cgtttctttt tttgccgtct ttttgtgatg aaaaagactt attttaggta
     4381 caaattgaga gacatctgac aagccgaatt tgttagaccc ttgatataaa tagaaaatga
     4441 gggtcaaacc aagaatgcag gcaaataata gtataaggtt aatgagagtg aaggcttttc
     4501 ttttttggcg ccgtttatgt ctattgttca ttacttgctc ctttttttga tataagtacc
     4561 tctattgtaa cattttttag agaaaagaag gcttgaagtc agcctttttt cttgtttttt
     4621 ggaagaacgt gtattaagga gtaaaaaaat tgttgtcaca gataacactt taggaggtag
     4681 caaagactat gtgggactgg tattcttatc acgtaaaaaa agcaatgaag ataaaagtgt
     4741 agtgtacttt agaacttatt tgagtgtttg gtgaggataa gaaaaaaaag ggtactactc
     4801 taggttatct gctgtcactt ttttttatat atggtatact aaagatagat gtgaggtatg
     4861 aaatgactta tgaagagact ctagaatgga ttcatgatca cttagttttc ggcatcaagc
     4921 caggcttaaa acgtatgctt tgggttcttg gacagttagg aaatccccaa aaaaatgtca
     4981 agggagtgca tatcgttgga actaacggaa aaggttccac ggtcaatcat ttacaacaca
     5041 tctttacgac agctggttat gaagtgggga cctttacctc tccttatatt atggatttca
     5101 aagaacgtat tagcataaat ggtcgaatga tttcagaaaa agatttggtt attgctgcta
     5161 atcgtattcg tcctttgaca gagcgtctag ttcgagagac tgattttgga gaggtaactg
     5221 aatttgaagt gattactttg atcatgttcc tctattttgg tgatatgcat cctgtagata
     5281 ttgctattat tgaagcaggc cttggcggtc tttatgattc gaccaatgtt tttcaagcaa
     5341 tggttgtggt ctgtccctca attggtttag atcaccaagc tattttggga gagacttacg
     5401 ctgatattgc cgcccaaaaa gctggtgttt tagaaggggg cgagaccctt gtttttgccg
     5461 ttgaaaaccc gtcagctcga gaggtttttt taacaaaagc tgagcaggtt ggtgcttcaa
     5521 tctgggaatg gcaagagcag tttcaaatgg ctgagaacgc atctggctat cgttttacta
     5581 gtcctttagg agttatttca gatattcaca tcgctatgcc aggacaccac caagtgtcta
     5641 atgcagcttt agctattatg acttgcttaa ccttgaaaga ccgctatcct aggctaactt
     5701 cagatcatat aagggaaggt ctagcaaata gtttgtggct aggccgtacc gaattattag
     5761 caccaaatct aatgattgat ggggctcata acaatgaaag cgttgctgct ttggtagccg
     5821 tcttaaaaaa taactacaat gataaaaagc ttcatatttt gtttggtgcg atcgacacca
     5881 agcctattgc agatatgttg gttgctcttg agcaaatagg tgacttgcag gttactagct
     5941 ttcattaccc taacgcctat ccattggaaa aatacccaga acgttttggt agggttgctg
     6001 atttcaaaga tttcttggcc ctgcgtaagc atgctaaagc agatgacttt ttcgtgatta
     6061 cagggtcact atattttatt tcagaaatta gacggtattg gaaaaaacat attgaaaaaa
     6121 gcgttctttt aacccattaa aaaagagaaa atgaaaagga aaaaactaat gaaaagggaa
     6181 agactaatgt ctattgataa ggaaaaagca gaagcagcca tttatcagtt tttagaggct
     6241 attggtgaaa atccaaatcg ggaaggtctt cttgacacgc ctaaacgggt tgctaaaatg
     6301 tatgcggaga tgtttttggg actgggaaaa gatcctaaag aggaatttac ggctgtcttt
     6361 aaagaacagc atgaggatgt ggtgattgtc aaagacatta gtttttattc tatatgtgaa
     6421 caccacttag ttccttttta tggcaaggct catatcgctt atttaccaag tgatggtcga
     6481 gtaacaggtt tgagtaaatt agcgcgagca gttgaagtag ctagtaaacg acctcaactc
     6541 caagagcgtt tgacctctca aatagcggat gctttagttg aagccctcaa tcctaaaggg
     6601 actttagtta tggtagaagc agagcacatg tgcatgacca tgcgaggcat caaaaagcca
     6661 ggtagtaaaa ccattaccac cactgccaga ggcttatata aggaaagtcg tgctgagagg
     6721 caagaagtta tttctctaat gacaaaagat taggagaact tatgaaaatt ggaaagtttg
     6781 tgattgaggg caatgcggct atcatgggga ttttaaatgt gactccagat tctttttcag
     6841 atggggggtc ttacactact gtgcaaaaag cattagatca cgttgagcaa atgattgctg
     6901 atggggctaa aatcatcgac gttggtggag aatcaacacg tccaggttgc caatttgtaa
     6961 gcgctaccga tgaaattgac cgggtggttc ctgtgatcaa ggccatcaaa gaaaactatg
     7021 atattctaat cagcattgat acctataaaa ccgaaacagc tagagcagct ttagaggcgg
     7081 gtgccgatat tctcaatgat gtttgggcag gtttgtacga cggtcaaatg tttgccttag
     7141 cagccgagta cgatgcgcct atcatcttga tgcataacca agacgaagaa gtttatcaag
     7201 aggtaacaca agacgtttgt gattttctag gcaatagagc acaagcagct cttgatgctg
     7261 gcgtgccaaa aaacaatatt tggattgatc caggatttgg atttgccaaa tctgttcaac
     7321 agaatatgga gttattaaaa ggattggacc gcgtctgtca gttgggttat cctgtcttgt
     7381 ttggtatttc gagaaagcgt gtcgtagatg ccttgttagg cggcaacacc aaagctaaag
     7441 agcgagacgg agcgacagca gccttgtctg cttatgccct tggaaaaggc tgtcagattg
     7501 tacgcgtaca cgatgtcaag gctaatcaag acattgtggc tgttttgagc tagttgatgt
     7561 gaggacttat ggataaaatc gtattagaag gttgccgttt ttatggctac catggagcct
     7621 ttaaagaaga acagaccctt gggcaaattt ttctggttga tttagaattg tcagtcgatt
     7681 tgcaagcagc ttctttgtca gaccaattaa cagatacggt ccattacggg atggtgtttg
     7741 atagtgtccg tcagttagtg gaagggggaa agtttatttt gattgaacgt ttagcaggtg
     7801 cgatttgtga acagcttttt aacgaatttc cacctattga agccatcaaa gtggccatta
     7861 aaaaggaaaa cccaccgatt gcaggccact ataaggcagt tggtattgaa ttggagagac
     7921 agagatgacc attgtttatt taagtttagg caccaatatg ggggaccgag cagcttactt
     7981 gcaaaaagct cttgaggctt tagctgactt acctcaaaca cggttgcttg ctcaatcatc
     8041 catttatgaa acgactgctt ggggcaagac aggccaggct gattttctca atatggcctg
     8101 tcaattagat acacaattaa ccgcggctga tttcttaaaa gaaacacaag ctattgagca
     8161 atctcttggt cgtgtgaggc atgaaaaatg gggatcaaga actattgaca ttgatatctt
     8221 gctatttgga gaagaggttt atgacacaaa ggaattgaaa gtgccacacc cttatatgac
     8281 tgagcgtgct tttgttttaa tccccttatt ggaattgcag ccagatttaa aattgcctcc
     8341 taatcataag tttttaaggg attatcttgc agctttagat caatcagata tcacactctt
     8401 ttcagctcaa cagacagagt tctagactct gttttcggag taatgcctgc tataagccaa
     8461 tccataaagt tttgccaaat tcatcgttat tttttctaaa atttgatata atagtatcgg
     8521 ctttatgccg atttttttac gtgtataaga agtgataaaa gaaagaagat aactatgata
     8581 actgaacttc atgggattga tattcgagag aatgaacccc taaaacatta cacttacact
     8641 aaggtaggtg gcccagcaga tttcttggct tttcctagaa atcactacga gctatcacgc
     8701 atcgttgctt atgccaacaa agaaaatatg ccttggcttg ttttgggaaa tgccagcaat
     8761 ctcattgtgc gagatggtgg tattcgtggc tttgtcatca tgtttgataa gctaaatgca
     8821 gtgcacttaa atggttatac cttagaagcc gaagctggtg ccaatctgat tgaaacaacg
     8881 aagattgcca aattccatag tttaacaggg tttgaatttg catgtggcat tcctggaagc
     8941 attgggggtg ctgtttttat gaatgcaggt gcctatggtg gggaaatatc acatattttc
     9001 ttatccgcta aggtgcttac ctcaagtgga gagatcaaaa ccatttcagc tagggatatg
     9061 gcttttggtt accgtcactc tgccattcaa gaaacaggtg acattgtcat ttctgctaag
     9121 tttgctctta aaccgggtaa ttatgatacg atcagccaag aaatgaatcg gttaaatcac
     9181 cttcgccaac taaaacaacc tttagaattt ccatcttgtg gatctgtgtt taagcgcccg
     9241 ccaggacact ttgcaggtca attaatcatg gaagcaaatc ttaaagggca tcggattggt
     9301 ggtgtggaag tttccgaaaa acacgctggt tttatgatta atgtggcaga tggcacagct
     9361 aaagattatg aagatttgat tgcttatgtc attgagacag ttgaaaacca ttctggtgtc
     9421 aggcttgaac cagaagttcg gattattggg gaaaacctgt aaccattatt gataattaaa
     9481 gaaagtaccg tggaggattt atgacaattg actaagccaa ttatcacatt taacaatgtt
     9541 tcaaaaacat ttgaggacag tggaacacag gttctaaaga acattaactt tgaccttgaa
     9601 gaaggaaaat tttacaccct gcttggagct tctggctctg gaaaatcaac tattttaaat
     9661 attatggcgg gcctactaga tgccagcagc ggagacattt atttagatgg ggaacgtatt
     9721 aatgatttgc cgattaataa acgtgacatt cataccgttt tccaaaatta tgccctcttc
     9781 cctcatatga ctgtttttga gaatgttgcc tttgctttga agctgaagaa agtggacaag
     9841 aaagagattg ctaagcgcgt gaaagaaacc ttgaaaatgg ttcaattaga agggtatgaa
     9901 aatcgttcta tccagaagtt atctggtggt caacgtcaac gtgttgccat tgcgcgtgcg
     9961 attatcaatc aaccgcgtgt ggtcttactt gacgaaccac tctcagccct tgatttgaaa
    10021 ttaagaacag agatgcaata tgaattacgt gaattgcaac aacgtctagg tattaccttt
    10081 gtttttgtta ctcacgatca agaagaagcc ttggccatga gtgattggat ttttgtcatg
    10141 aatgaaggtg aaattgttca gtcgggaaca ccagtggata tttacgatga gccaattaat
    10201 cattttgttg ctaattttat tggagaatct aatattatta acggtaccat gattgaagac
    10261 tatcttgtct cctttaacgg gaaagaattt gaatctgtgg acggtggaat gcgccctaat
    10321 gagcctgttg aagtggttat tcgtcctgaa gatcttcaaa ttactttgcc agaagaagga
    10381 aaattacaag ttaaggttga tacccaatta ttccgcgggg ttcactacga aattattgcc
    10441 tatgatgaat tgggtaatga atggatgatt cattctaccc gcaaagctat cgaaggagaa
    10501 gttatcggat tagattttac ccctgaagat cttcatatca tgcgtcttaa tgagactgaa
    10561 gaggaatttg atgcccgtat tgaagaatat gtggaaatgg atgagcctga agatggattg
    10621 attaatgcca ttgaggagga gcgtaatgaa gaaaacctct agtctttttt cgattcctta
    10681 cttcttatgg attctcttct ttgttgtggc accagtcact ctcttgtttt acaagtcctt
    10741 ttttgacata gaagggcgcg tgaccttagc caattatgaa acctttttta gctcttggac
    10801 ctatttgaga atgagtgtga attctatttt atacgctggt attatcacac tcgtcacgct
    10861 cttgatttca tatcctacgg ctctcttttt aacgcgccta aagcacaagc agttgtggct
    10921 tatgctcatt attttgccaa cttgggtaaa cttattgcta aaagcctatg cctttatggg
    10981 aatctttggt caacaaggag gaattaacag ctttttaact tttatgggga ttggcccgca
    11041 gcaaatcctg ttcacggatt tctcctttat ttttgtagcc tcttacattg agctcccttt
    11101 tatgatgtta ccgattttta acgctttgga tgatattgac cataatgtca tcaatgccag
    11161 tcgcgaccta ggagctagtg aatttcaggc cttctcaaaa gttatttttc ccctttcttt
    11221 aaatggggtt agggcaggtg ttcagtctgt ctttatccca agtttgagtc tctttatgtt
    11281 aacccgtttg attggtggaa accgggtgat tacacttggt acagccattg aacaacattt
    11341 tttgaccacc caaaactggg gaatgggatc aacaattggt gtcgtcttga ttttgaccat
    11401 ggttgctatt atgtggctca caaaggagaa aagtaaatga aaaaatttgc caatctttat
    11461 ttagcgagtg tctttgtttt actctacatt cctatttttt atttgatttt ctattctttc
    11521 aacaaaggtg gggatatgaa tggttttaca ggatttaccc ttgagcatta ccaaaccatg
    11581 tttgaggata gtcgtctcat gacaatctta ctgcaaacct ttgttcttgc ttttagtagc
    11641 gctctactag caacgattat tgggaccttt ggtgctatct ttatccacca tgttagaggt
    11701 aagtaccaaa atgccatgct atcagccaat aatgtcttga tggtatcacc agatgtcatg
    11761 attggggctt cctttttaat tctttttaca tcattgaagt ttcagctggg catgtcttca
    11821 gttttattaa gtcatattgc tttttcgatt cctattgtgg ttttgatggt attgccgcgc
    11881 ttgaaagaga tgaatcagga catggtcaac gccgcttatg atttgggagc taattatttc
    11941 caaatgctca aagaagtcat gctgccatac ttaacaccag ggattattgc tggttatttt
    12001 atggccttta cctattcctt agatgatttt gcagtgactt tctttttgac tggaaatggt
    12061 tttactactt tatctgttga gatttattcg cgggctcgtc agggaatttc cttggatatc
    12121 aatgctttgt caaccatcgt tttctttttc tccatcctct tagtgatcgg ttattattat
    12181 atgtcacagg acaaggagga aaaacatgcg taaactttat tcctttctag caggagtttt
    12241 gggtgttatt gttattttaa caagtctttc tttcatcttg cagaaaaaat cgggttctgg
    12301 tagtcaatcg gataaattag ttatttataa ctggggagat tacattgatc cagctttgct
    12361 caaaaaattc accaaagaaa cgggcattga agtgcagtat gaaactttcg attccaatga
    12421 agccatgtac actaaaatca agcagggcgg aaccacttat gacattgctg ttcctagtga
    12481 ttacaccatt gataaaatga tcaaagaaaa cctactcaat aagcttgata agtcaaaatt
    12541 agttggcatg gataatatcg ggaaagaatt tttagggaaa agctttgacc cacaaaacga
    12601 ctattctttg ccttatttct ggggaaccgt tgggattgtt tataatgatc aattagttga
    12661 taaggcgcct atgcactggg aagatctgtg gcgcccagaa tataaaaata gtattatgct
    12721 gattgatgga gcgcgtgaaa tgctaggggt tggtttaaca acttttggtt atagtgtgaa
    12781 ttctaaaaat ctagagcagt tgcaggcagc cgagagaaaa ctgcagcagt tgacgccgaa
    12841 tgttaaagcc attgtagcag atgagatgaa aggctacatg attcaaggtg acgctgctat
    12901 tggaattacc ttttctggtg aagccagtga gatgttagat agtaacgaac accttcacta
    12961 catcgtgcct tcagaagggt ctaacctttg gtttgataat ttggtactac caaaaaccat
    13021 gaaacacgaa aaagaagctt atgctttttt gaactttatc aatcgtcctg aaaatgctgc
    13081 gcaaaatgct gcatatattg gttatgcgac accaaataaa aaagccaagg ccttacttcc
    13141 agatgagata aaaaatgatc ctgcttttta tccaacagat gacattatca aaaaattgga
    13201 agtttatgat aatttagggt caagatggtt ggggatttat aatgatttat acctccaatt
    13261 taaaatgtat cgcaaataag cactcaaaaa ggctggtatt tctccagcct ttttaatgta
    13321 ttgacagatg acgtcaccag tacacgcgat agggacggcc aaccttggta aaaatttgtt
    13381 ggctgttcag ttgcttattt tcttctaaat aagcaatgta tttacggaca gagacatggg
    13441 ataagtgaca agcagaagct aattcttgga tagtaaaagg ttgatcaaag gctttgatat
    13501 tttccataat ccactggaaa gtggattcag ataagccttt ttctaacaat tgtttgtttt
    13561 tagtgtcttt tttgctagtc aaacatttca gttggtcaat ttgggcctgc tctagttgct
    13621 gattggccaa atgttctcga tgcgtaacaa actgttggat gctttcttga aagcgttcaa
    13681 aggtaaaggg cttgatgagg tagtcgataa ttcctaaatg aaaaccatct cggataatat
    13741 tcccatcatt tgcggctgaa ataataatga cttcgcaagg aatatgctga gcacgccatt
    13801 tctccaaaaa ttgaatccca ttgccatctg taatatgaat atccagtaaa atgaggtcaa
    13861 ttgcgtaatc agtaagtatg ctttgaacag ctttcataga gtcgctggat ataatgcgat
    13921 caaaaagatt tagtttttcg aggtaattgc gatggataaa atccaccata ggatcatctt
    13981 caatgattaa aacgttcatg ttgccctcct acataaggtg ttgtcactga gaactgtaac
    14041 tcggttacgg tttgatgttg atggaattgg gaatttgtat cggtcaagag ctgttgaaaa
    14101 taaggtaagt caaaaatagg ctgtacccgc tccaaatcaa tccaattgtc tgtcaaggtg
    14161 taatggctga ttaaatgatt ctgatcatgt tgaatactca aaacgagtga tttgggtctc
    14221 agtgtggtta gaagattagt atggataaag cggtaaatca tcaaaccatt attaagttga
    14281 ttcttggtgg cagaatgagg aatctcgctt aaaacatcaa tcttgagatg gacatttaat
    14341 tcttggtatt tctcttgctc tccaatgaga aaactagcta gaagaggctc cttaacaagg
    14401 acagataagc tagtgagaat ttcattttcg ggttccaaaa tactgtctaa ataaattttc
    14461 aattggtcat aataagcaat atccactaag ccataaataa catgcaattg attcatgaat
    14521 ttatgagttt gggcttgtag agcagaagca taggcagtgg tataggctag ctgatccaag
    14581 gtatcaatag ccttaactgc ttctcgcatg aaaataatgt ggcctcggtg atcgtttttg
    14641 acacagatgg gtgaaatggc taacaagtag tcttcctcac cataccgaaa gagttgttca
    14701 tgcccctctt gcaaactaag ttttggaaaa tcaggaaaga ggtgattgaa actgttgcca
    14761 gtaggttttc ccaactggca tttccgagca attaattttt gtccagcctg attgcagagc
    14821 tgtaagatac cagctttatc taccacaaat acggcggctt cgatttgatc caacatggca
    14881 ttacgctctt caaagagctg gtaaatttca cttggttcta actggtgcag ttgacgcttg
    14941 agtcgaaaag aaataaaact ggtgaccagt aaactaataa gaagacaaag gagtaaagac
    15001 agggtataat tgcgttttga cgttaaagcc acatcattta gggtagttag tttaatgcca
    15061 accgcaatag caccaatctg tttgtcaccg tcaaacacag gtactagata gcgaagtgac
    15121 tttcctaaag tgcccttggc ggtagagata accttttttc ctgctagaac agcctcctca
    15181 tcacctcctt gaaaaggttt tccgatattt ttcgggttag gatgggtgag tcgaatccct
    15241 ttcatgttca tcacgaccac ataatcaagg ttatagatgg aggcaatgga gttggtatag
    15301 gctgttgttt tagcatttgg ttggttgttt aggagtaatt ctttaattgc ttgatgactt
    15361 gctaacattt ttccagttga cgttagcaaa tgggtttcct gatttttgat ggattggtgc
    15421 gtatcatgta gcataatccc gtaaaataga gaggttgtga caacaatcat agataccaaa
    15481 atcaacgata aactggccca taaacgtagt ggttttttca taaggtctcc tctttattga
    15541 gtataacacg ataagaaatg acctgctagc ttaaattaat taaataactt gaaaaaatta
    15601 aagtagttaa acaacttaaa taaactatgc ttttgacatg ttctctttta tactagcctt
    15661 atcactaaag gaggttgttt catggaaaca ataagcaaga aaatgcctca aaaagacttg
    15721 tctgagcatt caaaagcatg gcaaaatagg cgaataggct ccgttccctt gcctgtttat
    15781 ttggttttag ctaccttaat tttagtcaca ggctggctcc aacagttgcc tgttaatatg
    15841 ctgggtggct ttgctgttat tttaaccctt ggttggctac taggaaccat tggagcgacc
    15901 attccaggcc tcaaacattt tggtggccca gctattttat cactcttagt cccttcgatt
    15961 ttggtttttt ttaatctcct caaccccaat gtcttagaag cgacgaatgt cttgatgaag
    16021 caagccaatt ttctttattt ttatattgcc tgcctggtct gcggtagtat tttaggcatg
    16081 aatcgaaaaa tcttgatcca aggtcttttt cggatgatta ttcccatgtt acttggaatg
    16141 gtttgtgcaa tgggtgtagg gactttggtt ggcgtcattt taggattaga ctggcaacat
    16201 accctctttt atgttgtgac accagtcctt gctggaggaa ttggtgaagg tattttaccc
    16261 ttatctcttg gttacagtgc cattacagga gtcggaagtg agcaattagt ggctcaactg
    16321 attccagcca ccattattgg gaatttcttt gctatcttgt gcacggcttt gctcaatcgt
    16381 tttggagaga agcatccaag ttattctggt caagggcaac tggttaaaat tggtcacagc
    16441 gaagacatgt ctgatgccct aaaagacaat tctggagccc tagatgttaa attaatgggg
    16501 gcaggcgttt taacagcttg ttcacttttt attgctggtg gcttgttaca gcatttaaca
    16561 ggttttccag gaccggtgtt gatgattatt ctggcagcct tcttgaaata cctgaatgtt
    16621 attccccaag aaacccaaaa tggtgccaaa caactttata aatttatttc cagcaacttt
    16681 acttttccgt taatggcagg gcttggtctg ctttatatcc ccttaaaaga ggttgtggca
    16741 acccttagct ggcaatattt tattgtggtg attagtgtgg tgttaacggt tgtcagtgtc
    16801 ggtttttttg tctctcgttt ccttaacatg aacccagtgg aagcagctat tatttcagct
    16861 tgtcaaagtg gtatgggtgg aacaggggac gtggctattt tgagtacggc tgaccgcatg
    16921 aatctaatgc cgtttgccca agtcgctact cgtctaggcg gggccattac cgttatcacc
    16981 atgacagcta ttttaagaat tatttttagt taatccaaac caataaaaag agaggtattt
    17041 cctatgaaaa atcaattagg tcaacttgcc cttgaacaag ctaaaacgtt cggaggtaaa
    17101 ttggaagttc aaccaaaagt tgacattaca aataaacatg atttgagcat tgcctataca
    17161 ccaggtgtag ctggtgtgtc atctgccatc gcaaaagata aaacattagc atatgactta
    17221 accaccaaga aaaatacagt agccgttatc agtgatggta ctgcggttct tggtctgggg
    17281 gatattggcc ctgaagcagc catgccagtt atggaaggaa aagcagccct ttttaaagca
    17341 tttgcaggtg tcgatgctat tccgattgta ttagatacca aagatactga agaaattatt
    17401 agtattgtca aggcgcttgc accaaccttt ggtggtatta atttagagga tattagtgcg
    17461 ccccgctgtt ttgaaattga gcagcgcttg attaaggaat gtcatattcc tgttttccat
    17521 gacgatcagc atggaacagc tattgtggtg ttagcagcca tcttcaatag tttgaaactt
    17581 cttaaaaaat cccttgatga ggtatccatt gtggtgaacg gtggtggatc tgctggatta
    17641 tccattaccc gtaaattatt agcagcaggt gctacgaaag tgacagtagt ggataaattt
    17701 ggcattatca atgaacaaga agccgctcaa ttagcgccac atcatttgga tatagcgaaa
    17761 gtcactaatc gtgagtttaa atcaggtacc ttagaagatg ctcttgaagg agcagatatc
    17821 ttcattggcg tatcagcacc aggagtctta aaagcagagt ggattagtaa aatggcagcg
    17881 cgcccagtaa tttttgccat ggccaaccct attccagaga tttaccctga tgaagccctt
    17941 gaagcggggg cttacattgt aggtactggc cgcagtgatt ttcctaacca gattaataat
    18001 gtccttgcct ttccaggtat ttttagggga gcattagatg cacgggcaaa aaccattact
    18061 gttgagatgc aaattgctgc cgcaaaaggt attgccagtc ttgtcccaga tgacgctttg
    18121 agcactacta atattattcc agatgccttt aaagaaggag tcgctgagat tgtcgctaaa
    18181 agcgtcaggt cggtagtcct taaatcatag aatatatgaa aaaaagagaa agttatactt
    18241 taaatcacaa aataagtaga agcatatttc tagcttctac ttattttgtg attagctaat
    18301 atcattatca ataataactt tcaaggcgtt atttacacca gcatgtttaa aggtttcata
    18361 agctttttca acttctgaaa gtttaaaatg atgtgtaata agtcttgttg cgtcaatctt
    18421 tccagttttc aagacattta gtagcatttc agttgtattg gcattaacaa gtccagtgtt
    18481 taaggtgata tttttaatcc ataattcatc caggttgaaa tcaactggtt tcccatgaac
    18541 cccaacgtta gcaatatgcc cacctactga tataattttt tgacaaatat caaatgtcgc
    18601 gggataacca acacactcca tggaaatatc gacaccacgt ccattggtta tatcgtcaat
    18661 gatagccttg acttcttcac tacttcctga acaaatcgtg tgtgtggctc caaatgtttt
    18721 agctgcttca aggcgatttt gagataagtc gaccataata atattggctg gagagaaaaa
    18781 ttgaacggtt agtagggctg cgagtcctac tggaccggcc ccaacaatac aaacattatc
    18841 tccaggcttg acatgtgatg gcaagacacc aatttcatat gaagttggta aaatatcaga
    18901 aagcatgaca agtgcctcat catcaatcgt atcaggagca tgatagagac taccatctgc
    18961 atgtgggata tggacatatt ctgcttgtgt tccattaatt aaatggccaa gaatccaacc
    19021 gccatcttca caatgtgacg aaaggcctcg tttacaataa taacaggtat gacatgatgt
    19081 gacgcaagaa ataatcactt tatctccgat tttaaagtta gtaaccgcat caccgacctc
    19141 cttaacaatt ccaattcctt catgaccaag gattgttcct tctttacatg cgggaacatc
    19201 cccacctaag atatgcaaat cagttccaca aatagtggtt tttaccaact ggacgatagc
    19261 atctgtaggc tttataatga ctggttttgg tttgtctatg agctgtagat ttccggttga
    19321 aaggtaagtt gctgctttca tatttaactc cttataaggt tgagaggtaa tcaaccaatt
    19381 catttttaca cagatattat aatagtttaa gaaagggttt tcaatatttt ttaaatcgat
    19441 tatgataatt ttttagatca tctttgttga ataacttcat ccttattcag aacttaaagg
    19501 gcactattat aagaatttga aaccgcttta cttaaatcgt gtatttttgt acaataatga
    19561 ttaaggaggt ttttagatga aaaaagaatt taccagtatc ctgtttacag ttagtttttg
    19621 tggaatcata gcattgcctg tcgaagctag tggccctaaa gttccttata cacaagaagg
    19681 tataacggcc atttcaaatc aggcaacagt aaaattgatt tctattgctg atatcgcgag
    19741 cagtttagaa ggacaaaaac ctataacggt tagttttgat atcgatgata ctttgttatt
    19801 tactagccaa tattttcaat acggcaaaga atatataact ccaggctcat ttgatttttt
    19861 gcataagcaa aaattttggg acttggtcgc taaacgggga gatcaggatt ctattccaaa
    19921 agagtatgca aagcaactaa tcgcaatgca tcaaaaacga ggagataaaa ttgtctttat
    19981 tactggccga actcgaggat cgatgtataa aaaaggtgag attgataaaa cagctaagtc
    20041 actggctaaa gattttaagt tagacaagcc aatagctatc aattatacag gagataaagc
    20101 tgtgaagccg tatcagtatg ataaaacata ttatataaag aaaaacggct cacaaattca
    20161 ttacggagat agtgatgaag atataaatgc tgccaaagag gcaggtgcaa gacctattcg
    20221 cattttaaga gctcctaatt caactaatct tcctttgcca aaagctggag gatacggaga
    20281 agaggtttta gaaaattcgg cttattagtc aaatatttgt gtaagaaagg aagtaacagt
    20341 aatttctttc atcaccccac tgagtaacca atagcccagt gggttttttg ggttacagaa
    20401 atcagttcta aaaaagaatc actggtaact taaggttgtc tttgatacaa tggtaacagt
    20461 gtatttaaaa gaaagagagg ataacatgga aaaccataaa aatgaattca ccttttccaa
    20521 caaatcaatt attgcctatg tttggcgtgg tgttatggtt ggtattattg ctggtgttat
    20581 tgttagttta ttccggttgt taattgaagt gacagctgac tgggtgattg aatggtaccg
    20641 atacgctcat atcaattcgc tgttgctact tcctatacta agtgtcagtt tattagctgt
    20701 tctttttgta ggttttttag taaagtctga ttctgatata aaaggatcag ggatccccca
    20761 tgtcgaagga gaactaaagg gactaatgtc cccagattgg tggagtgtcc tttggaaaaa
    20821 atttttagga ggaatcatgg ctatttctat gggatttatg ctcggtcgtg agggtccttc
    20881 gattcagtta ggtgctatgt cagccaaagg attagctaag tttttaaaat cgagtcgttt
    20941 ggaaaagcga gtgctaattg ccagcggagc agcagcaggg ctatcagcag cttttaatgc
    21001 tccaatagca ggcctcttgt ttgttgttga agaaatttac catcattttt cgcgtttaat
    21061 ttggattaca gcgctagtgg ctagtttagt ggctaatttt atttctctga atatttttgg
    21121 attgaaacca atcttagcaa tgtcagaggc gatgcctttt ttaggactca atcaatattg
    21181 gttgttgctt ttacttggat tatttctagg ctgcttaggc tatttatatg agatagttat
    21241 ccttaatttt aataaacttt atgttatttt agggagttgg ttacatctgc cagcttattt
    21301 ttacggtatt attatggttt ttctaatttt accgattggc tattatttac cacagttact
    21361 tggaggaggg catggtttaa tactttcttt atccaatcaa caattgcctt tgatgactat
    21421 cttcttttat tttattattc gatttattgt tagtatgttt agttatggaa gtggcttacc
    21481 tggaggtatt tttttaccta ttttaacttt aggtgctttg gcaggcctat tatttgggca
    21541 aatagcttct caattaggtt tattgaacca atcttttctt tctctttttt tgatattagg
    21601 gatggcaggg tattttgcgg caatttcaaa agcaccactg acaggcatga ttttggtaac
    21661 tgaaatggta ggtgatttga aacccttaat ggccatagct gtagttactt ttgtctccta
    21721 tttagtgatg gatttgttaa atggacagcc aatttacgaa gctatgctag ataagatggc
    21781 aatgaagcat ccaactaatc ttgttgaacc aacattaatt gaattgactg ttggtgataa
    21841 gattgcaggg aaatatgtta aagagttaaa gcttccagaa aatgtcttaa ttacaaccca
    21901 aattcaccat caaaaatctc aagttgtgtc aggtaacacg cgccttttgt caggagcaac
    21961 tatctttttg gtcgttaatg aagctgatac aggttttgtc cgtgaggtat tgatgtaggt
    22021 attaatttat cacaattcgg aaagttcgag cttgtctttt agactaagtc ttcgaacgtt
    22081 ttactgctag agtttcatct gaaccaaagt gaaacgcttt tgatgaagtc aagtaggctt
    22141 tttgttatac taacaataaa gataagctaa ggaggctgag atgttagaaa ttgtttcaga
    22201 agagctacgt cactatcaag aacaaaaatt gattgagtac cgtaacaaaa atcagttagc
    22261 cccaaaagga ggcattgtat ttgcaggtga ttctctcatt gaattttttc ctttaaaaaa
    22321 agcttttggt tcatgtttgc ctattattaa tcgaggtatt gctgggatag atagtcagtg
    22381 gttattgcgc catttttctg tccaaattac tgatttagag cctaaacata tttttttatt
    22441 aattggttgt aatgatatcg ggcttggata tgataaatgt catattgtca agactattgt
    22501 agagcttatt agccagattc gtagtcattg tgtctacagt cagatttatc tcttatcttt
    22561 attaccagtt tccaacaatc cccgatatca gaaaactgtc aaaataagaa caaatgctat
    22621 gattgatgct attaataaag atttagcaat gattccaact atagaattta ttaatcttaa
    22681 tacttgtctt aaagacgaaa aaggtggttt atcagatgag aatactctag atggtttaca
    22741 tcttaatttt ccagcttatg ctaaactagc tgaaattatt caatcttata tctagccaat
    22801 aaatgtacta atagcgatga ggcaagaagt cagatagcag atggttcatc aatcaattaa
    22861 gaaaaaagtt atcaagatac cattaaaaat agttgctcaa agttctttca aatcaaaaga
    22921 ttatgatatc gctatgttga gttttagtgt ataatgataa ttaaaggagt taccatgaaa
    22981 tttgaaaaaa aacaagtctt ctatttagtc cttacgttta tcttatgcta tgggatccta
    23041 gcaaactggc gaaatggaac ggctatcgtc acgactattt acaaaacaag ccttcctttt
    23101 ttttatggag cagcaggtgc ctatattgtt aatattgtaa tgagcgctta cgaaaaggta
    23161 tatgtttata tctttaaaga ctggtcacat gtcttaaaag taaaacgggg tatttgttta
    23221 ctgttagcgt atttgacatt ttttatttta attacttgga ttatttccat tgtcattcca
    23281 gacttaatta caagtattag tactctaaca aaatttgata ctataacgat acaagaagtt
    23341 gttaacaatc ttgagcacaa taaactgtta gcacgtacta ttcagtatat tggtggcgat
    23401 ggcaaactta cagagacgat tgctaactat agtcaacagt tattaaagca atttcttact
    23461 gttttgacaa atattttaac atctgtcacg gttattgctt ctgcaattat taatcttttt
    23521 attagttttg ttttttcgtt atacgtttta gcaagtaaag aagatctttg tcgtcaggga
    23581 aatactttag tagatactta tactggtaag tacgctaaac gcattcatta cttgttagag
    23641 ttgttgcatc agcgttttca cggatttttt gttagtcaga ccttagaagc tatgatttta
    23701 ggttcgctga ctgctagtgg catgtttata ttaagattac catttgcagg gactattggc
    23761 gttttagtag cttttacagc attgattcca gttataggtg cttcaattgg agcagctatt
    23821 ggatttattt taattatgac tcagtccatg tcacaggcta ttatttttat cattttttta
    23881 attattttgc agcagattga aggtaatttt atttatccga aagtagttgg tggatcgatt
    23941 ggattaccgg ctatgtgggt attaatggca attacaatag gcgcttcttt aaagggaata
    24001 gttggtatga ttattgcagt tcctttagca gcgacacttt atcaagtgat taaagataat
    24061 attcaaaaaa gacaagctat tcaaaaaaaa caagtttcct aaaaggaact tgtttttttg
    24121 tcgaataaaa agatggaggt aatatgataa atgtattcta taaaatgtga tgataataaa
    24181 gccatgccaa gagaacgttt gatgcgacta ggagcagagt ctctaagtaa tcaagaatta
    24241 ttagcaattt tattacgaac aggtaataaa gaaaagcatg tcttagagct gtcatcctat
    24301 cttttatcgc atttagacag tctggcagat tttaaaaaga tgtctttgca agaattacaa
    24361 catttggcag gtataggaaa agttaaagcg attgaaatta aagctatgat tgagttggtt
    24421 tcccgaattt tagcgacaga taagacatta actgatagcg tattaaccag tgttcaggtc
    24481 gctgaaaaaa tgatggcagc tttaggagat aaaaaacaag agcatttagt cgtattgtat
    24541 ttagataatc aaaatcgtat tattgaagaa aaaactattt ttattgggac tgtccgacgt
    24601 tcacttgcag aaccaagaga aattttatac tatgcctgta aaaatatggc gactagtctc
    24661 attgttattc ataatcatcc ttcaggaaat attgaaccta gttctaacga ttattgcttt
    24721 actgaaaaaa taaaacgatc atgtgaagat ttaggcatta tctgtctaga tcacattatc
    24781 gttagctata aagattatta tagttttcga gaaaaatcaa ccctttttta agtcagaagt
    24841 cattgacgaa taagcggaac aattgtagat cttcatctcg aacaccttgg agaagttcag
    24901 gatgccactg aacacctaaa aaaggaatgg catcgttggt tgatatgact gcttcgatgg
    24961 taccatcacg tggatctcta gcgattactt ttaaatcctt agcaacagtt tttaaacttt
    25021 ggcgatgaaa agaattaatt aatgtcttat gaccataaat aggatataag atagagtctg
    25081 gctcaataat catttcgtgt gataagaaat cagaaggcgc ttcttgccaa tgtgagtcaa
    25141 tgtgttggtt aagatttcct cctaaggcaa cattcattaa ctgtgtacca cgacaaatcc
    25201 ctaagattgg tttttttaat gttatagcct ccttgatgat agctagctca aatgtgtctc
    25261 gctctggtga aaaatcatca tcaaaagcag ccttctcttc ttgataatat tttgggtcaa
    25321 cgttttgccc accaattaaa atgattttat caaccataga tacataagtt ttagcggcgg
    25381 cttcatcacc aatgggtaaa agaagcggca gccccccaga ttgagtgact gcctgtacaa
    25441 atccagtagg tgcatatgac catgggagat tatccaaagc catatttagt ctctgatttg
    25501 cagttattcc aataatcggt ttggtcatta tacctcctta atctagatga ttttgattca
    25561 taaaatagag tagtgtctgg agctcactgg tcaaatcgac agattgaaca ataactcctt
    25621 taggaacttg taggtgaaca ggagcaaaac tcaagattcc tttgattcct gcttcaataa
    25681 gttgatcagt aactttttga gcatgaatgc tgggaaccgt taagatagcc gtttcaatgt
    25741 cagtgttcgc aatccgttct ttgacagatg agataccatg gactggaata ttatcagctg
    25801 ttttagtacc aacaagagcg ttatcatcgg tatcaaaacc catggcaatt tgcatcttat
    25861 tacgatcatg gaagcggtaa tgtaatagag cacgccctat attaccgcat ccaactaaga
    25921 taacgtttgt tgtagagtga tcattaagca agtcagcaaa aaaattcatc aatttggtaa
    25981 catcatagcc aaacccacga cgccccaatt ctccaaaata agaaaagtca cggcgtacag
    26041 tagcagagtc aattcccatt gcatctgcaa tttgtttaga actggctttt tcaacttggt
    26101 cagcatggaa tcgtttaaaa atacggtaat aaagtgataa gcgctttgca gtcgcttttg
    26161 gaatagattt gtcaataacc actattttac tccttgtaga tttctcgtta aatatgtctg
    26221 tctttattgt aacaaaaaga ttgtgaaaaa tgcaacattt tgattgtttt tgtatgagtt
    26281 aaaaaagcta aaattagttt tagcactata taatagtatt cattaggaaa gtaagttatg
    26341 acagtcaaaa tgaacaacat gaattaatag caatagaagc gaaatcattt attgacattg
    26401 tgatatgact aaaaaacaaa atttaaagtt gattagacga ctgttttgct aaaaatttca
    26461 cgttctacaa ggctgtccat caagaaataa aatttatctt gaaggatttg attatctttt
    26521 gttttaaaaa tattaactaa tctaagacca gattgatcgg tgatagctaa tttaaaacct
    26581 gtgagttctt tattaatagt gatttttaaa gggaaaccat cccctgaatt aggtattgtt
    26641 tcgagtaaac gtattaattg gtagtgccct actttagttt gactaaatgt agtatctctt
    26701 agggtatatt ttttaatgtt tggactgatt gtataaaggt atttacagtc tttaagctta
    26761 atttcttttt caaaagccat ctgttcctcc taaaatattt tttaatgttt gagctaattg
    26821 attaacatct tcaatgctat tttgatctga aaaactgata cgaattgatt cttttaaacg
    26881 agaagagtca tccccatagt acgcagctaa aacatgactt ggattaacag ctccagcagt
    26941 acaagcagaa ccagttgata ctgcaatgcc tgctaagtca agttgtgtta gtaaaatagt
    27001 attttggtag cctaaaaatc caatattgag aacatgagga agataatgag taccttgatt
    27061 aatatagtag ggtagtcctt ctaggaggct aatcaagtga tgacgtaaac tgataatgtg
    27121 atcagttgat tggtcaagac aagtcatagc atcagtcaaa gcttgtgcca taccaataat
    27181 acctaacata ttttcagtac ttgcgcgtcg ctttccttct tgatcacccc cgtgaagaag
    27241 agggtcgatt ggttgtccgt tactgtataa aaagccgcat cctttaggac catgaaattt
    27301 gtgagcagaa gcagataaaa agtcaatccc aagttcgcta ggaataatct tgagtttgcc
    27361 aacagcttga acggcatcaa catgaaaagc agcttgatgg tctttgagca gattcccaat
    27421 gtccttaata ggtaacaggt cacctgtttc gttattggca tacattatgc ttaccaaaat
    27481 ggtgtcatct ctcaaggctt gttttaagtc agataaattt atttgtccat tttgacaagg
    27541 caaataagtg acctcaaaac caaatcgctc ttcgagatag gccatggtat gaagaacaga
    27601 gtggtgctca atagtagttg tgatgagatg tttgcccttt gcttgatgag ctaaagcata
    27661 gccttttatg gccatattat tgctttcagt tccaccggac gttactataa tttgctgttc
    27721 acttgccccc aagtttctag cgatagcttg tcggcattca cgaaggattt tattggctcg
    27781 gcgcccgtag aaatgaatac tagaggggtt accaaagtta tcttgcatag ctgctgtcat
    27841 cgccctaatc acattaggac taagtggtgt ggtggcggcg ttatcaaagt aagtcatgcg
    27901 ttatttttgc ctttaggttg ataagaaaaa agtggactta agggtcttct ttcatggata
    27961 cgaataatag cttctgcgat taaatcactg gcgctaagat aagtaacgtt ttctggcaca
    28021 cgatttttag ttttaacaga atctgtaacg ataatttctt tgattagagc tgtttctaat
    28081 acatcagcag ctccaccagc aaataagcca tggctagcga ccgcgtaagt atcagtagcg
    28141 cctgagcgtt caagaatttt agcagcttct gcaaaggttt tcccagtatt taaaatatca
    28201 tcaattaaaa tggctttttt accagaaaca tcaccaataa tataaccttg ttcacgttca
    28261 gaatcatctt gtgcatagtc gataatagca atcggggaat caagatattc agccaagctt
    28321 ctagcacgtt taattccaga atttttaggg ctaacgacaa caacatcaga acctgataag
    28381 cctaatttac tgtaacgttc tgcaaaaaga gggactgtaa agaggttatc cactggaata
    28441 tcaaaaaaac cttgtacctg aacagcatgt aagtcaagcg tcactacacg atcaatacca
    28501 gctttagtca gcatattagc tactagttta gcagtaatcg gttcgcgggg cttagcgaca
    28561 cggtcttgac gagagtaacc aaagtatggc aatacaatat tgacggtatt agcacttgca
    28621 cgtttacaag catcaatcat gatgagtaat tcccaaagat tatcattgac aggaaaacta
    28681 gtggattgaa taatatagat atcatctcca cgaactgttt cttcaatatt gatcataatt
    28741 tctccatcgg aaaattgacg tgaagacatt tttccaagag ggattccagc agctttagca
    28801 attttttcag caattggaag atttgatgtg agtgagaaca gtttgatttg cttgtcagca
    28861 tatcgttcag tcatgataga tttagctcct taacttcaat aaaattgggt aaactgtttt
    28921 attaatgagt cacattaccc aaaagtgttt aattgacatc cctattttaa cagaaaaaca
    28981 gaaaaatttc agtttttctg tcgcttttag ccattattta tcgttgaact tttttaaggt
    29041 attaatacac cgagctactt tgcttttagc atatttgaaa gtaatgtgat gttcagataa
    29101 aaaagaatca aaatcaatct ttccttgaag agcgtcactt acttctaatt ctaattcata
    29161 gtctttggta ttggcatata ggttatagtc taaggccaat ttacctatcg gtatcactgt
    29221 ctcgcgacga acggtagtta aattgccaaa agttaccagt gcagatggtt tgataccttt
    29281 tgaaataata atatcaagag cagttgattc aggaagattc ccatgtttaa tcatatcttt
    29341 tgcttgttca agaaaaagag ggacattgta ctcacgattc cccacttttt ctggcacttt
    29401 taaggttaat tcggcgctat ttacaaatgt tcgaatacgt aatgacattt tgttagcttt
    29461 taaatcaaat gcttttgtat caatatagta attagtttgt gtaacaggcg tcacatgttt
    29521 catttgaaat aaaagacggt tatactcatt ttttgtaagt agagttttat attcgatttc
    29581 taggttagtc atgggaaatt ccttttaatt tgtgctataa taaattgtta tttcaatttt
    29641 atattattat cctggctttg acaagaaagg agacaataga tgaccttaga ttgggaagaa
    29701 tttttagatc cttatatcca aacagttggt gaattaaaaa taaaactacg gggtattcgc
    29761 aagcaatatc gtaagcaaaa tcgttattct ccgattgaat ttgttacggg acgtgttaag
    29821 tcaattgaaa gtattaaaga aaaaatgatt ttacgtggtg ttattgaaga aaatatagca
    29881 caagatattc aagatattgc tggactacgt attatggttc agtttgttga tgatgtggaa
    29941 gaagtcttag ctctattgcg tcaacgacaa gacatgacaa ttgtttatga acgagattat
    30001 attcgcaata tgaagtccag tggctacagg tcttatcatg tggtggttga gtaccctgtt
    30061 gataccattg agggtcaaaa aaaggtctta gcggagattc agattcgtac tttggcaatg
    30121 aacttttggg cgaccattga gcattcttta aattataaat atggtggaga cttcccagaa
    30181 gaaattaaaa agcgtcttga agtgactgct aaaattgcct tagaattaga cgaagaaatg
    30241 cgtaagattc gagaagatat tcgggaggct caattattgt ttgaccccgt gacacgaaat
    30301 ttaagtgatg gtgtaggaaa tagtgatgac acagatgaat tatacaggta aggtaaagcg
    30361 agttgctatt attgcaaatg gtaagtacca aagtaaacgc gttgcctcca aacttttctc
    30421 cgtatttaaa gatgatcctg atttctatct ttcaaagaaa aatccggata ttgtgatttc
    30481 tattggcgga gatgggatgc tcttatctgc ttttcacatg tatgaaaaag aattagataa
    30541 ggtacgtttt gtaggaatcc acaccggtca tcttggcttt tataccgatt atagggattt
    30601 tgaagttgat aaattgattg ataatttaag aaaagacaag ggagaacaaa tctcttatcc
    30661 tattttaaaa gttgctatta ctttagatga tggtcgtgtg gttaaagcgc gtgctttgaa
    30721 tgaagcgacg gttaagcgta ttgaaaaaac gatggtagca gatgttatta ttaaccatgt
    30781 caaatttgaa agcttccgag gtgatgggat ttcagtatcg accccgacag ggagcacagc
    30841 ctacaataaa tctttaggtg gtgctgtctt gcatccgacg attgaagcgc tgcaattgac
    30901 ggaaatttcc agtcttaata accgtgtctt tagaaccttg ggctcatcaa tcattattcc
    30961 caaaaaagat aagattgagt tagtgccaaa acgattagga atttatacca tttccattga
    31021 taataaaacc tatcagttaa aaaatgtgac gaaggtggag tattttatcg acgatgagaa
    31081 aattcatttt gtttcctctc cgagtcatac gagcttttgg gaaagggtca aggatgcctt
    31141 tattggagag attgactcat gagatttgaa tttgtagcag ataaacgaat aaaagtaaaa
    31201 acccttttaa aaagtcatga tgtctctaaa ggactattgg ctaaaatcaa atataagggc
    31261 ggtaatatat tagtgaatgg tattgaacaa aatgccattt atttattgca agtgggagat
    31321 gttgtcacca ttgacattcc aaacgaagag ccctttgaaa agcttgaagc catccctttt
    31381 gatttggata ttgttcacga ggatgatcat tttttggtga ttaataaacc cattggcttt
    31441 gccagtattc caagtgccat ccactccaat accattgcta actttatcaa ggcatattat
    31501 gtggacaatc attacctaga ccaacaagtg catatcgtga ctcgtttaga cagagatacg
    31561 agtggcttga tgttatttgc taagcatggt tatgctcatg caaggttgga caagcaactc
    31621 caaactcgct caatagagaa acgttatttt gctctggtgt ctggaaatgg gacgttgcca
    31681 gatgaaggag atattattgc tccaattggg cgttcaaaag atagtattat taccagggca
    31741 gttgacccta tgggcaaata tgccaagact agctataagg ttgtggcgcg ctattcagaa
    31801 aatgtgcatt tagtggatat caaattgcat acaggacgta cccatcaaat cagagttcat
    31861 tttgcccata ttggttttcc acttttaggg gatgaccttt acggaggtcg tttggactta
    31921 ggaataacaa ggcaagcttt acattgtcat tatttgaatt tcaaagatcc atttacagaa
    31981 agtgattgta gctatgcaat acacttgaca gatgactttg atagcgttat cataggttta
    32041 cagaaaaaag atagaggtta ttaaagaatg agtattcgta gtttattcgg tggtttaaga
    32101 gaaaaaattc ttggtaaaaa catgaagatt gtttttccag aaggtaatga tgagcgcgtc
    32161 gtccgtgcag ctgctcgttt gaaatttgaa ggactcttag aaccgattat ccttggacag
    32221 tcagaagagg tacgcaacct tttgacaaaa ttaggtttcg ctgatcaaga ctatactatc
    32281 attaatccaa atgaatatgc ggattttgac aaaatgaaag aagcttttgt tgacatccgt
    32341 aaaggaaaag caacgcttga agatgctgat aaaatgcttc gtgatgtgaa ttactttggt
    32401 gttatgttgg ttaaaatggg attagcagat ggaatggtat ctggtgctat tcattcaaca
    32461 gctgatactg ttcgtccagc ccttcaaatc attaaaacca aaccaggtat ttcaagaact
    32521 tcaggtgttt tcttgatgaa tcgcgaaaat acgagtgagc gttacgtgtt tgctgattgt
    32581 gctatcaata ttgacccaac agcacaagaa ttggcagaaa tcgctgttaa cacagctgaa
    32641 acagctaaaa tctttgatat tgatcctaaa attgctatgt taagcttctc aacaaaaggt
    32701 tctggtaaag cgcctcaagt tgataaggta agagaagcaa cagaaattgc taaagggttg
    32761 aaccctgatt tggcacttga tggtgagttg caatttgatg cagcctttgt tcctgaaaca
    32821 gcagctatca aagcaccaga ttcagcagtt gctggtcaag ctaatacttt tattttccct
    32881 gacttacaat ctggaaatat tggttacaaa attgcacaac gtttaggaat gtttgatgct
    32941 attggaccaa tcttacaagg attgaacaaa cctgttaatg atttatctcg tggctcaagc
    33001 gctgaagata tttacaaatt agctattatt acagcagcac aagctattga aagccaaggg
    33061 taacttaaga ccccttgata taggatccta accgctaagt gatgtgttag aagttgtcct
    33121 aagactaatt gacattatta aaaacgagtt ggccagacca tctcgttttt tttgagggtg
    33181 aggaaatgta tgggaaatat tgccttagta acaggggctt cagccggttt tggcagagcc
    33241 attgtcgaac acttaattgc agatgggata aaggttattg gtgcttctcg tcgtcttgag
    33301 aaactcaagg ccttagaaac gagctttggg tcggacaact tttacccttt gcagatggat
    33361 gtcacagata ccaaagcgat tgatgatgct ttgacaagtc taccaaatca gtggcaagat
    33421 attactattt tagtgaataa tgcaggcttg gcattgggac ttgataaggc ttatgaagcc
    33481 gattttgaga attggatgac gatgattaac actaatattg ttgggttgat ttatctcaca
    33541 cgtcaattat taccacatat ggtctccaaa gatgatggta ttattattaa tttagggtca
    33601 accgcaggga caattcccta tccgggagct aatatttatg gggctagcaa ggcttttgtt
    33661 aagcagttct cactcaattt acgagctgat ttagcaggta gccatatacg tgtgaccaat
    33721 attgaacccg gtctatgtga agggacagaa ttttcaaagg ttcgctttaa tggtgatgag
    33781 gcacgggtga aggccattta tcaaggagca catgccattc aacctcaaga tattgcgtcg
    33841 actgtatcat gggtgattca tcagccccct catgttaatg ttaatcgtat tgagctaatg
    33901 ccagtgtcgc aaagttatgg accgcaacca gttactcgtg actagcaagg gatgagtcca
    33961 taagaataat aatctttaga aaaatggttt actggaatgg attattcttt ataagtgaga
    34021 cttaccgatt tagtcatcaa aaaaagcagt caagaagaag gttttgatgt ttccaagtgt
    34081 tcttgattgc ttcttgtgcg ttgatgattt aggctggact ccctattaaa atcaagttta
    34141 gtgatctaaa atggaaggac ctgatgtcac atcggaccag ccaacaatgg cttgtccagt
    34201 ttcttctaaa tactggctta ataacggttt aatgtcttgg acggtatcca aaactcccac
    34261 cagctgacct tgaggatttt taagagcttg ataatgctgc atgtaaatat gatccaatga
    34321 acccgaagga agtaggaagg ttttacaagg gttatctgat aaacgcaatt cagcaagaat
    34381 ccaatcttct atttcgttat cagtagttgg caaaaaactt ccattaaaag catgattatc
    34441 gactagaatg ttcccctttg cgtcagataa ccttgcttgc aaaggaaggt attctaaaaa
    34501 atgtctatca aatttttggt aaaatctagt gaggtattgg cttaacgata agactgctgt
    34561 tgcttgatca aagacacttt ctgtcactaa aaatccctga ccatgttgag aggttttgaa
    34621 atagagtgta ggcaagtcaa tgtcatgctc atggaaactg aaaattcctt ggaaagtcga
    34681 caattgattt gactcaatgt tggctttgct agtgagaata gtcacctcaa aaaggtgtga
    34741 gaagtggtgg gaaagctctc taataaacgt atcttcaagt tggttttcag gtgttaagag
    34801 cgctaaaatg gaaatggcat ttttcataat tgtatgatag ccgtattttc tagaaaagac
    34861 aactaatctg cttatctatc ataggcaagt ctaggatttt tgataaggta attttggaga
    34921 gataggctga caaagtgacc tgtttttcta taaggggtaa ggagaaatag tctcattatt
    34981 tgacttatag tgggaaactt tttataatgg tcaacaacaa acgacaagaa aataatgaga
    35041 gaaaatgttt ttgagaattg gtagttttta ccttactgag gatccctaag agtcccttta
    35101 attagtagat gcgtttgtct aaaaatggta gggcatgcag tgattccttg tagttactca
    35161 gaacgttttg agaaaaaatg acagagagac aggttgaatg aactcatcag cttttatgct
    35221 gttactttaa ccaatgaatt ggagaaataa tgatacgttt taataatgtt tctaaaactt
    35281 ttggtcagac aaaggttttg caagagcaga cctttcaaat taatgaccgt gaattttttg
    35341 tgctggttgg ccccagcgga tcggggaaaa ccacactttt aaaaatgatt aactgcctta
    35401 ttgaaccaag ctctggagat attttactga ataacgtccc acagaaagag ttagatttac
    35461 gtgagatgag gctatctatt ggatacgtgt tgcagcaaat tgctcttttc cccaatctca
    35521 cagtagctga aaatattgcg attatccctg atatgaagca atggtcagct gaagaaatta
    35581 gacaaaaaac tgaagaatta ttggataagg tgggcctacc tgctaaagat tatcttgatc
    35641 gttacccaag tgatttatcg ggaggtgaac agcaacgtat tggtattgta cgtgctatca
    35701 tttctcatcc taaaattcta ttgatggatg aaccattttc agccttagat cctatttcac
    35761 gtaaacaatt gcaagagtta atgttgagtc ttcacaagga atttgacatg acgattgtat
    35821 ttgtgacaca tgatattgat gaggctatta aattaggaga ccgcgtggct attttaaatg
    35881 agggagaaat tgtgcaactg gatcgcccag aaatgattaa gacccaccct gctaatgctt
    35941 ttgtggccaa tttatttgga ggtgatgagc atgcctagtt tgtttgtaac tttccaaaac
    36001 cgttttaatg aatggctggc ggctctgggg gaacacctgc aaatttccct tttatctctt
    36061 atgatcgcct tgctaatagg cgtgccttta gcagctcttc tcagtcgcag caaacgttgg
    36121 tcagacatta tgttacaggt aacaggtgtt tttcaaacca ttccctcact ggctttgctt
    36181 ggtcttttca tccctttaat gggaattgga acgttgcctg cagtgacagc tttagttatc
    36241 tatgcgattt ttccgatttt acagaacacc atcacagggt taaatggtat tgacccaagt
    36301 ctcgtggaag caggaatagc ttttgggatg accaaatggg agcggttaaa aacgtttgag
    36361 attccaattg ccatgcctgt cattatgtca ggtgtgcgaa cgtcagcagt catgattatc
    36421 ggcacagcta ctttagcttc cttgatagga gccggtggac ttggctcttt catcttattg
    36481 gggatcgatc gtaataatgc taatctgatt ctgatagggg ctatttcttc agctctgcta
    36541 gctattattt tcaatagttt gttacagtac cttgagaaag cttccttgcg acggattata
    36601 attagttttg gaatcacctt acttgcattg ctagcatcgt atactcctat ggcgcttagt
    36661 cagttttcaa aaggaaaaga tacagtggtt attgccggta aattgggagc agagcccgat
    36721 attctgatta atctctataa ggaattaatt gaagaccaat cagatataag cgttgagttg
    36781 aaatctaatt ttgggaaaac tagcttctta tatgaagccc ttaaatctgg agatattgat
    36841 atctatcctg aatttacagg aactataaca tcaagtcttt tacgcgacaa accaccgttg
    36901 tctaatgacc ctaagcaggt ctatgaggat gctaaaaaag gcattgctaa gcaagataaa
    36961 ctgacccttc ttaagccatt tgcttaccaa aatacgtatg ctgttgctat gccagaaaaa
    37021 ttggctaagg aatatcagat tgaaaccatt tctgatttaa aagcgcatgc tgatacttta
    37081 aaggctggtt ttactctgga atttaaggac agagcagatg gctataaggg aatgcaatct
    37141 caatatggat tacagctatc tgtggcgacg atggagccag ctcttcgtta tcaagcaatt
    37201 caatcaggag atatccaagt aacagatgct tactctacgg atgctgaaat tacgaaatac
    37261 catttgaaag ttttaaaaga tgataaacag ttgtttccac cttatcaggg agctcctttg
    37321 atgaaaactt ccttattaac aaaacatcca gaattaaaag gcattcttaa tcaattagcg
    37381 ggaaaaatta ctgaaaaaga gatgcaggac atgaactacg aggtatctgt taaaggagca
    37441 gatgctaata aggtcgctcg agattatctg ttgaaaacag gcttaatcca gaaataaaca
    37501 gaaatgttgg tccgtaggac tggcattttt tcgtctctta agttcaagaa gtaacaattc
    37561 ataaatacaa aaaccgaact ttaaaattaa aaatagcata taaatttgac aaaatataaa
    37621 caaataagta atctataaaa tgaaaggtaa gtttttacct aaagatacct ctaatcatca
    37681 gaggtcatag gaagattatt ttgtatagag gacttagaga agaaggtgag aactgactta
    37741 ttttctttca tctgtgctaa aagaggagaa acttatgttt aatgacatcc ctgtatttga
    37801 ttatgaagat attcaactga ttcctaacaa gtgcattatt actagtcgtt cacaagcaga
    37861 tacaagtgtg acactcggaa aataccagtt caagctacca gttatcccag caaatatgca
    37921 aaccattatt gatgaaacaa ttgctgagca attggcaaaa gagggttatt tttatattat
    37981 gcatcgtttt gatgaagata gccgcaaacc ttttatcaaa cgcatgcatg aacaaggctt
    38041 gattgcatcc atctctgttg gggttaaagc ttacgaatat gaatttgtga cttctttgaa
    38101 agaggatact cctgagttta tcaccattga tattgctcat ggtcatgcta acagtgttat
    38161 tgatatgatt aagcatatca aaactgaatt accagaaaca tttgtcattg ctggaaatgt
    38221 tggtacgcca gaagctgtac gagaactcga aaatgcaggt gctgatgcta ctaaagtagg
    38281 catcggtcca ggcaaagtat gtatcactaa agttaaaaca ggtttcggta caggtggttg
    38341 gcagttagca gcactgcgct ggtgcgcaaa ggcagctcgt aagcctatca ttgctgatgg
    38401 tgggattcgc acacatggtg atatcgctaa atccatccgc tttggagcta gtatggtcat
    38461 gattggttcg ctttttgcag ggcatattga aagtcctgga aaaacagtag aagtgaatgg
    38521 tgaaacgttt aaagaatatt atggctcggc gtcagcatat caaaaaggcg agcataaaaa
    38581 tgtagaaggc aaaaaaatct tattgcctac aaaaggtcac ttatcagata ccctgaccga
    38641 aatgcaacag gatttgcaat cgtccatttc ttacgcgggt ggtaaagatt tagacagttt
    38701 gcgtcatgtt gattatgtta tcgtcaaaaa ttctatttgg aatggtgatt ccatttaaat
    38761 gatatggagt tagctaggac cagtaaagaa ttttttagct taatgctgga gatgctttta
    38821 tcatatctct gtaggtattg aaaaaaataa gaaacatggt aaaatagtaa attatcataa
    38881 tgaattcaat aatgacatac ttatttatgc tgtgaattgg cgcagcgtct ctacaagaca
    38941 ccttaatgtc taacaataag taagctttta ggcttgcttg gtttttaacc ttgcaaagtg
    39001 agaaactctt atagtttctg gctttgcggc aggctttttc tatttgaatc aaaaggagat
    39061 ttatgcagtt acttgaagaa cgcatcttaa cagatggcaa tattctagga gagaatattc
    39121 taaaggtaga taatttttta actcatcaag ttgattaccg gttgatgaaa gcaattggta
    39181 aagtgtttgc tcaaaaatat gctgaggctg gcattacaaa agtggttaca atcgaagctt
    39241 caggtattgc accagccgta tacgctgcag aagcaatgga tgttcctatg atttttgcga
    39301 aaaaacataa aaacattacc atgacagaag gcattttgac agcagaagtt tattctttca
    39361 ctaaacaagt gacgagcacg gtgtctatcg ctggtaaatt cctatctaaa gaagacaagg
    39421 ttttgattat tgatgacttt ttagctaatg gtcaggcagc caaaggcttg attgagatta
    39481 ttggtcaagc aggggcacaa gtcgtcggcg ttggtattgt gattgagaaa tctttccaag
    39541 atggtcgtcg attgattgaa gatatgggca ttgaagtgac ctcattagca cgtattaaaa
    39601 actttgaaaa tggtaatcta aacttcttgg aggctgacgc ataatgacac attcaacaaa
    39661 gcaggaacat tctcactcgc aatcagctgt ccttggctta cagcatgtgc tttcgatgta
    39721 tgccggatct attttagtac caattatgat cgcaggtgct ttaggttatt ccgctagaga
    39781 gttgacctac ctgatttcga cagatatttt catgtgtggt gtggctactt tcttacagtt
    39841 aaagttaacc aagcatacgg gagtgggatt accagttgtt ttaggatgtg cttttcaatc
    39901 agtggcacct ctatccatta ttggagcgca acaaggttca agtgccatgt ttggagccct
    39961 cattgcgtca ggaatttatg tcattttagt ggcaggtatt ttttctaaga ttgctcggtt
    40021 cttcccacca attgttacag gatcggtcat taccgttatt ggcttaagtc tcgtaggtgt
    40081 tgctatgggg aatatgggag ataacgtcaa agagcctacg gcacaaagcg tgatgttatc
    40141 attgttgacg attgtcatta ttcttttagt ccaaaaattt accaaaggtt ttgtgaaatc
    40201 catttccatt ttgattgggc ttgtagcggg aactttggtt tcagctatga tgggattagt
    40261 agatacaact cctgttgtag aggcttcttg gattcatgtg ccaaccccat tttattttgg
    40321 catgccaact tttgacatca cttctattgt gatgatgtgt atcatcgcaa cggtttctat
    40381 ggttgaatca acaggtgtct acttagcgct ttcagatttg actaatgatc aattagatga
    40441 aaaacgtttg cgcaatggtt atcgctcaga agggatcgca gtctttctcg gtgggttatt
    40501 taataccttc ccttacactg gtttttctca aaacgttgga cttgtccaaa tctcaggtat
    40561 taaaacccgt cgtccgattt actacgcagc aggtatcctt gtggtcattg gcctactccc
    40621 taaatttgga gcaatggcac aaatgattcc aagcccagtt cttggtggag ccatgcttgt
    40681 tctctttggt atggttgctc ttcaaggaat gcaaatgctt aatcgtgttg atttccaaaa
    40741 gaacgagtat aattttatta ttgctgctgt ttccatttca gcaggtttag gctttaatgg
    40801 cactaatctt tttgccagct taccagagac agctcaaatg ttcttaacga atggtattgt
    40861 gattgccact ttgacatctg ttgtcttaaa tttagtttta aatggcaaag acaaacaaga
    40921 tgaataatta aaaaacggct aattgagccg ttttttctgt gatcagtttt gagcaaaccg
    40981 ttaacccctt ttaatgatag tatggttgaa aatagtgtct caaaccattt gacataagga
    41041 catggtgctt tcttgttact agaagacctt caatattatc aaaggtgttt aaaagtgtga
    41101 taatcattga gctatcaaga ccaaataaac gggtagccca tatgtcacaa tccaaagaag
    41161 aagaggccat gaccgttaag ctaagcatat ctgtttctat agggtagcct gtctgacgat
    41221 ctaagatatg atgatactgt ttccctttag ctgtaaactg cctttcataa attccagaag
    41281 tcacaacaga gtgattgtta accttgatga caccaagatg ttgcccacgt ttagcatctg
    41341 gtttttgaac gccaattcga aaagtcttgt cagggctttt cggattaggt ccatgaacta
    41401 aggcgtttcc acctaaatta ataagggcag agtcaatacc atcttcaatc aggtaggcca
    41461 taatcttatc agtaatataa ccttttgcta aggctcctaa gtctaaagcc attcctactt
    41521 gttgtaaaaa gacagtctgt tttttgtcat ctataagaac ctgtctagga tctgttagag
    41581 ctaactgttg tgagataagg ttatgactag gcactatagc atcttcaaat ccaattcgcc
    41641 aggcttgaac aagtggccca atggcgatat taagattact tggtgttgac aagctatgtg
    41701 ctttaccaat ttggattagg ttaaataaat cagagtggac gctgacgggt ttaacaccag
    41761 ccgcctgatt aatagccatc aattcagagt ttgaatcatt agctgaaaaa cgatttttgt
    41821 aagtatataa taagtcaatg actctactta gttgttggca agctttgtca gatttgatct
    41881 gaatatcaat aactgttccc attagcttta attgttgcgt aacaaacata attagtcctc
    41941 tttttagcag aataccccca ctaaggagtg ggggaaggtc attatgattt ttgtttcatt
    42001 tcaccttgag gatagtaagt tccttcaggc atatcgttga taaaaacatg gatattttct
    42061 ttaggtgctt ttgcaatgcg tgatactact tcggtaacct cgcgagctaa ttgatttttt
    42121 tgttcttgtg agcgtccctc aaacaagtca attgttacaa atggcataat gttactcctt
    42181 tatgttattg ggcatcattg taacataatg ctgtgaaaaa gtacacactg ttttcaatgg
    42241 ctgggaaaac ttcagccttt gtggtaaaat aggtagaata ctatagaaag taggattttc
    42301 cgctttggct caactctatt ataaatatgg gacaatgaat tctggtaaaa ccattgaaat
    42361 tttaaaagtt gctcataact atgaagaaca aggcaaacct gttgtcatta tgacaagtgc
    42421 tcttgataca cgtgatggtt ttggcatcgt ctcaagccgt attggtatgc gacgagaagc
    42481 tattcccatt tcaaatgaca tggatatttt cacatttatt gcccaattgg aagaaaaacc
    42541 ttattgtgtc ctgattgacg aaagtcaatt tttaagcaag caaaatgttt atgatttggc
    42601 gcgtgtggtg gatgagctaa atgttcctgt catggctttt ggtttgaaaa atgatttcca
    42661 aaacaatctt tttgaaggtt caaaacattt gctattattg gccgataaga ttgatgaaat
    42721 caaaacaatt tgccaatact gtagtaagaa agcaaccatg gttttaagga cagaaaatgg
    42781 aaaacctgtc tatgaaggtg atcagataca aattggtggt aatgaaacat atatcccagt
    42841 ttgtcgaaaa cattatttta atccagagat ttaaaaggta atcggtttta aaggagatac
    42901 aaagaaaaat gaatatttat gatcaattgc aggcagttga agatcgttat gaagaattag
    42961 gtgagttact tagtgatcca gatgttgttt cagatacaaa gcgatttatg gaattatcac
    43021 gtgaagaagc taatactcga gaaactgtca cagcttatag agaatataaa caagtcattc
    43081 aaaccatttc agatgctgaa gaaatgatca aagatgccag tggtgatcct gaattagaag
    43141 aaatggctaa agaagaactt aaagaatcaa aagcagctaa agaagagtat gaagaaaaat
    43201 taaaaatcct tctattacct aaagatccta acgatgataa aaacattatt ctagaaattc
    43261 gtggtgctgc tggtggcgat gaagcagcgc tttttgctgg tgatctttta acaatgtatc
    43321 aaaaatatgc tgaaactcaa ggatggcgtt ttgaagttat ggaatcatcc gttaatggtg
    43381 ttggtggtat taaagaagtg gttgccatgg tttctggtca gtcagtttat tctaagctta
    43441 aatatgaatc aggagctcat cgtgttcaac gtgtcccggt gacagagagt cagggtcgtg
    43501 ttcatacgtc aactgcaact gttttggtaa tgccagaagt tgaagaagta gaatacgaca
    43561 ttgatcaaaa agaccttcgc gtcgatattt accacgcgtc tggtgctggt ggtcagaatg
    43621 tcaataaagt tgctactgca gttcgtatgg tacacattcc tacaggaatc aaagttgaaa
    43681 tgcaagaaga acgtactcag caaaaaaacc gtgataaagc gatgaaaatc attcgtgctc
    43741 gtgttgctga ccattttgcg caaattgctc aagatgaaca agatgctgaa cgtaaatcaa
    43801 cagttggtac tggtgatcgt tcagaacgta ttcgtactta taatttccca caaaatcgtg
    43861 taacagatca tcgtattggt ttgacacttc aaaaattaga tactatttta tctggaaaaa
    43921 tggatgaagt tattgatgca ctcgttatgt atgatcagac aaagaaatta gaatctctca
    43981 ataactaatg aactatgcta cattaatcag aacttatgaa gataaactag aacaaataga
    44041 tgaggatcgc gaaaatctcg cctatgtttt tagagaaatc aaagaatggt caagtctaga
    44101 tatgttgatt caccaaaatc aagctgtgac tcctgaagat gctgttcttt tggaacatat
    44161 tttctgttct ctaagtcagc atttatctcc tcaatatatt acaggtaatg cttattttcg
    44221 tgatttgaag cttgcagtcg acaagcgtgt attaattcca aggccagaaa cagaagaatt
    44281 agttgacatg attttagctg aaaatcttga tgcaccgttg aatgttttag atattggtac
    44341 aggtagtgga gcgattgcta tttctctcaa aaaagaaagg cctaactggc aagtaacggc
    44401 atctgatatt tctagagctg ctcttgactt ggcaaaagct aatgctgatg cttaccagct
    44461 tgatataacg tttattgaat cagatgtttt tagtctcatt tcaggaacct ttgatattat
    44521 tgtgtcaaat cctccctaca tatcctacga ggataaggaa gaagtcagtc taaatgtttt
    44581 gcaatcagag cctcatttgg cactttttgc taaagaaaat ggctatgcta tttaccgtaa
    44641 gattattgaa caagctgaca attacttaac taaggagggg aagctttact ttgaaattgg
    44701 ttataagcaa gctgaaggta taaaagatat gttacaagcc tattttcctc aaagacatat
    44761 acgagtcgta acggatatat ttggcaaaga aaggatggtg gttgttgatt atggagtatc
    44821 tagctagtat cattgaatta ggtgatgccc ttgttttgcc aacagaaacg gtttatggtc
    44881 ttttcgccaa ggctttagat gaaaaagcag taaatgctgt ttatgactta aaacaaagac
    44941 cccgagataa agcaatgaac cttaatgtgg ctgattttaa tagtatctta gccttttcaa
    45001 aagaacagcc gagatacctc aagaaattat accaagcctt tttaccaggt ccgttaacga
    45061 ttattttaaa agctaatgac caggttcctt attggattaa ttcgggtctt tcaacggttg
    45121 gttttcgctt acccagtcat ccaattaccg cagctttaat tcaaaaaaca ggccctttaa
    45181 ttggtccttc tgcaaactta tctggcaaag ctagtggtcg agtttttgat catattatgc
    45241 aagattttga ctttcaagtg tttggttatg cagatgatcc ttttctaaca ggtaaggatt
    45301 caaccatctt agacttatca ggtgagtgtg ctgtgatttt acgtcaaggt gctatcacca
    45361 aagaagaatt attagccaac gtgcctgaac ttcgctttta agagaggagc cgcttggaat
    45421 gttgagacca ttaagtaaaa cggactgtcc tatgctacaa gaaattaacg ccaaagccct
    45481 tggctattta gtttcgcttg acttgttaga aaggcaatat gaacgattga ttgaggattg
    45541 ccatcactat tttttagctt atgccgacaa ggataccaat caattattag gctatgttca
    45601 cgctgaacgt tatgagaccc tttatgcttc tgatggtcta atctcttggg cttggctgtt
    45661 ttaccagcct atcagagaag gggaattggg agtgccttac taagggccct ggaatcccaa
    45721 gctaagcagg aaggcattgc ctttattcgc ctcaattctg ccagtcatcg taaagaagca
    45781 catgcttttt accgaaacct cgactatgca gatgataaaa cacaattacg attcatcaaa
    45841 aacttacaag gagatgacaa tgatttttga taaaggtaat gttgaagact ttgataaaga
    45901 gctttgggat gccattcatg ctgaagaaga aagacaagaa catcatatcg aattgattgc
    45961 atctgaaaac atggtttcaa aagctgtcat ggcagctcaa ggttctgttt taaccaataa
    46021 gtatgcagaa ggctatccag gtaatcgcta ttatggtgga acagaatgtg tggatattgt
    46081 cgaaacgctt gctattgaac gtgctaagaa acttttcggt gccgcatttg ccaatgttca
    46141 agcccattcc ggaagtcaag ccaatgcagc agcttatatg gccttgattg aggctggtga
    46201 caccgtatta ggaatggatt tggctgcagg tggtcatctc acgcatggct ctccagtaaa
    46261 tttttctgga aaaacctacc attttgtggg ttactcagta gatgctgata ctgaaacgtt
    46321 aaattatgag gcgattttag aacaagcaaa ggcggtccag ccaaagctta tcgttgcagg
    46381 ggcttcggcc tactctagaa gcattgattt tgaaaagttt cgtgccattg ctgatcacgt
    46441 aggtgcttac ttaatggtgg acatggctca catcgctggc cttgtagcag caggtgtgca
    46501 cccgagtcct gtcccttatg cgcatattgt gacatcaaca acccataaaa ccttacgtgg
    46561 tcctcgtgga ggcttgatat taaccaatga cgaagctctt gctaaaaaga ttaattcggc
    46621 cgttttccct ggtttacaag gaggacctct ggaacacgtg attgctgcca aagcggttgc
    46681 cttcaaagaa gccttggatc cagcctttaa agactatgca caagctatta ttgataatac
    46741 tgcggctatg gcagcagttt ttgcacaaga tgatcgtttc cgtctgatct caggtggtac
    46801 agataatcat gtctttttag tagatgtcac taaggttatt gctaatggta aactagcgca
    46861 aaatcttctg gatgaggtta atattaccct taataaaaat gccattcctt ttgaaacctt
    46921 gtcgccattt aaaacctcag gtattcgcat tggttgtgct gccataacca gccgtggtat
    46981 gagtgttaaa gagagtcaga ccattgcccg tcttatcatc aaagccttgg ttaatcatga
    47041 tcaagaaact attcttgaag aagtccgtca ggaagtgcgt cagttaaccg atgctttccc
    47101 actctataaa aagtaaggaa tcatgttaga tagttatata aaacgtattg tcattcatca
    47161 attttctccc aatgacactg agttactgtt atcagatcgt ttagtgagca ttacaccacg
    47221 aattgatgaa tatttccgga aaaaattggc taaagtgttc tcggatgaag ccaaacgggg
    47281 tcagtttgag gctaataata ccttttttac aaccattggt gatgatttgt tggaaacgtc
    47341 tgttaccatt gcccagttat ggaaggaagc ctttgttatt tcagaggatc aaaaaaccaa
    47401 tgatttagtc tttgtccagt ttgataagga tggcgaaccc ttttttgctt tcttgcgaat
    47461 tgctttgaaa gaacagtttg ctcacctttc tgacaattat gaacatccat ttacggtgac
    47521 gcagaataat ctgccgagtc ccacccagac accagatgaa gcactagtca ttaatctcaa
    47581 atctggtcag tactacttga ttgaaaagcg tgtgaagcat aatggcagtt ttgctaatta
    47641 tttttcagaa cacctcttga aagttacacc tgagcaatct gttaaaaagt ctatcaaaat
    47701 gatagaacaa accgctcaaa aaattgcaga gcattttaat caagatgatt ttacttttca
    47761 gtcaaagatg aaatccactc tttttaagca gttagaagca gacgacgttt tatcaccaga
    47821 aaaattagct gaccaactct ttgatgataa tttaacagcc cgtttaacct ttgtggatca
    47881 agtcaaagaa gtcattccag aacctataaa aattagcgat attgatcatt ctagacagat
    47941 aaaaaaacta gaaaatcaaa agctatcgtt atcaaacggg atagaattaa cagtaccaaa
    48001 tgccatttat caggatgctg aagcggttga atttttgtta aatgatgatg ggacttattc
    48061 aatcttgatt aaaaatatag aggatattaa aaccaaatag atgtttagac ttttaaagcg
    48121 tgcctgcagt tttcttcttc tttttgtcat ttatcaatcc tttgttattc atcacaatgt
    48181 tcaacgtgtt ttggtatata agcctatggt tgagaaaaca ttagcagaaa atgatacaaa
    48241 ggcaaatgta gacttagtct tagctatgat atacaccgag acaaaaggag gagaagcaga
    48301 tgtcatgcaa tccagtgaaa gcagttcagg acaaaaaaac tcgattacag atagtcaggc
    48361 cagtattgag cacggggtga atttactgtc tcataatctt gctctagctg aggaagcagg
    48421 agtagattct tggacggctg ttcaggccta taattttgga acagcttata ttgattatat
    48481 tgctaaacat ggaggtcaaa ataccgttga tttagcgact acctattcca aaaccgttgt
    48541 ggcgccaagc ctaggcaaca ctagtggtca aacctatttt tattaccacc ccctcgcctt
    48601 gatttctgga ggtaagcttt ataagaatgg cggcaatatc tattactcac gagaagttca
    48661 tttcaatctt tatttaattg aactgatgag cctttttaga aagttatcat gaaacgatta
    48721 cgtccatatg tgaaagggta cctaaaagaa agtatcttag gtcctctttt taaattatta
    48781 gaagctttat ttgaattatt agtccctttg ttaattgcta acatgattga tatatcgatt
    48841 agtcaacaca acagccaggg aattttgagg gttgttttaa cattatttgg tttagcaacc
    48901 attggcttat tgctttccgt tacagcccag tatttttctt caaaagcagc tgttggtttt
    48961 acaagacaaa tgacagatga tttgtttaaa aaaatcatgt ttttgagcaa ggaggaccaa
    49021 gaccatcttg gttatgctag tctgttatca cgattgacca gtgatagttt tcaaattcaa
    49081 actggtatca atcaattttt gcgtcttttt ctaagggccc ctattatcgt atgtggtgct
    49141 atggtaatgg cttattggat tagtccaagt ctaaccctat ggtttgtgat gatggtgatt
    49201 gtcttactaa cacttgtttt tgttatgtca catttattag atccccttta tctcttaatc
    49261 cgccgagaaa cagatcactt ggttcgtttg actagccaac agttacaagg aatccgagta
    49321 attaaggctt ttaatcaaac ccaaaaagaa ctccaagcat ttaagcagca aaatatgctc
    49381 ttaagtcgcc accaatatca agctgctacc ctagccaatg tcttgaatcc tatgactttt
    49441 ttagtggtca atcttaccct gttaatcttg atttggcaag gaagttggca agtagcccat
    49501 agatcgctta gtcagggcat gttagttgct ttaattaatt acctcttgca gattttggca
    49561 gaacttttga aaatgaccat gttgatggga accatcaatc aaagtgtaac agccgcaaaa
    49621 cggattaatc aggtgtttgt tttagctgat gaagcgcctt tgcccttact taaagatggt
    49681 cctatttcaa ctcatctgtt gaccatccgg cacttgacct ttacttatcc aggagcagca
    49741 gagccaagtc tgtatgatat tcagttaagt gctgatcagg gagaatggat tggcatcatt
    49801 ggtggtactg gagcaggcaa aacgactttg attgacttga tctgccaaac ttattcacaa
    49861 tatagtggtg agattagtct taattggcaa ggagaagtgc caaaaacact aaccgagtgg
    49921 cgaaatgtga ttgctcttgt tcctcaaaaa gctcaattat ttaaaggaac gattagaagt
    49981 aacctcctac tgggacaatc aatacctatt agtgatgagg aactgtggcg ggctcttgaa
    50041 ttggctcaag caaaagagtt tgtcgctgcc ttaccagaac aattagaggc acctgttgaa
    50101 gccttcggcc gtcatttttc aggagggcaa cggcaacgtc tagctattgc cagagcactt
    50161 ctgaagccaa aacccatttt gattttggat gatgccagtt ccgccttaga caatgagact
    50221 cgaggacgac tttttaaagc tctaaaagaa gagttatcag atgttttagt gattctagtc
    50281 acgcaatcca ttaagaattt gcagtttgct gataagattt tagtgttgga acagggccat
    50341 caattggatt ttgccagtca tgaccagtta aaagtaagca atgcacttta tcaagaaatg
    50401 ctagcgcttt acgtgaaggg ggagcaaaaa tgattaaaac agatcatcac ctcctaaagc
    50461 gaatgcttca ggatttgtta aaaaaacctc tacctgtttg tattctcgtg atagctagtt
    50521 ttgtacaagt tggtttaagt gtttacttgc ctgttcttat cggtaaagcc gttgatatga
    50581 gtttgtcagt caattcttgg caaactttaa aatggctgtt ggggcaaatg ttagttgtta
    50641 ttgtggtcaa cacattgatt caatgggtga tgcctcttgt ctatagtcgt ttgctatatc
    50701 aatatagcca gcaattgaaa gataagcttt tggaaaaaat tcatcgtctt ccttttgcat
    50761 atctagatcg tcaaactatt ggagatttgg ttagtcgagt gataaccgac actgagcaac
    50821 tgatcaatgg tctacaaatg gtttttaacc agtttatact tggactattg acgattctgt
    50881 gtaccattat agctatggca cagattgact ggctcatgtt aatcttggtt ttggtgttaa
    50941 caccaagctc cctcttttta gctcgtttta ttgctcaaaa gagttttcat tatgcacaag
    51001 cacagaccaa aagcagagga aatttagctc agtttactga agaaatcctt cgtcaagaag
    51061 gtttggttca actgtttaat gctcaagagc agtctatctg tgattatcat gttttaaata
    51121 aaacctattg cgaggcttca caaaaagcca ttttttacgc ctcaacagtc aatccagcca
    51181 ctcgctttat taatagtgtc atttatgctt tactggcagg tttaggggct gttcgtatca
    51241 tggctggact tttttcagta ggtcagctaa ccactttttt aaatgttgtt gtccaatata
    51301 ccaaaccttt caacgatatt tcatctgtct tggcagagat acagagttct ttagcttgtg
    51361 cgcaaaggct ttatgacctt ttagatattg aaataaaaga gcaagagcac tttctaacat
    51421 ttaaggcatc agcggttaag gggcaaattg actttgaaga agtaagtttt tcttatcaaa
    51481 aagacaggcc cttactgaag gatattaatt tttctgttcc tgcgggttcc aaggtagcga
    51541 ttgtagggcc tacaggtgca ggcaaatcaa ctttaatcaa tttactcatg cgcttttatg
    51601 aacttgatgc tggtagcatc aagttagata aagttcctat taagtgttat gctaaggaag
    51661 aacttaggtc cattactggc atggtattgc aagaaacctg gttgaaagat gcgactgttc
    51721 atgagttgat tgcttacggc agtgaagagg ctagccgtga tgaagtagtg gcagcagcca
    51781 aagcagctca tgcacacttc tttattatgc aacttcctaa gacttatgat acttacttaa
    51841 gtgcttctga tgatgctttg tcccaagggc agctccagtt attagctatt gccagaatgt
    51901 ttttgaaaaa accaaaagtc ttgatcctag atgaagccac ctcctctatt gatattagaa
    51961 cagaagctgt tattcaagag gcactaaaag aactcatgag aggaaggacc agctttatca
    52021 ttgcccatca tttatcaacg attcaatcag ctgatttgat tcttgttatg gatcaaggtc
    52081 gattggttga gtggggaaca catgccagct taatgtcaaa aaacggatgt tatgctagat
    52141 tacaaaagat agaataaagt tcgtctttta acaaaggtga actttttaag tcttcctaaa
    52201 gttagttaat taacaaactt taaactgtta tataaaaaaa ataacagcga aaaagtggac
    52261 gatctttttt tataagtgag aaaaaacagt tgactaaaga aaaaataact caaaaaagtg
    52321 agcaatatat ttggaagcgt tttttgactg tggtataata gagccctata taatattgtg
    52381 aaatgaggaa caaaatatat gagtaaaatc gttgttgttg gtgcaaacca tgctggtacg
    52441 gcctgtatca agactatgtt aacaaactac ggtgatgcta atgagattgt tgtatttgac
    52501 caaaactcaa atatttcatt tttaggctgt ggtatggcac tttggattgg tgagcaaatt
    52561 gctggaccag aaggactttt ctattcagat aaagaagaat tagagtcctt aggggctaaa
    52621 gtttacatgg aatcacctgt tcaatcaatc gactacgatg ccaaaacagt gacagcgctt
    52681 gttgatggta aaaaccacgt ggaaacttac gacaagttga tttttgcaac tggctcacaa
    52741 cctatcttac caccgattaa aggtgccgaa atcaaagaag gatcacttga atttgaagca
    52801 actcttgaaa atcttcaatt tgtgaagtta taccaaaact cagctgatgt gattgcaaag
    52861 cttgaaaaca aagacattaa acgtgtagcc gtagttggtg ctggttacat tggtgttgag
    52921 ttagctgaag ctttccaacg taaaggtaaa gaagtggttc tgattgatgt cgtggacact
    52981 tgcttggcag gttattacga ccgtgatttg actgacttaa tggctaaaaa catggaagaa
    53041 catggtattc aactagcctt tggtgaaaca gttaaagaag tagctggtaa tggtaaggtt
    53101 gaaaagatca ttactgacaa aaatgagtac gatgtggata tggttatcct cgccgttggt
    53161 ttccgtccaa acacaactct tggaaatggt aagattgagc ttttccgtaa tggtgctttc
    53221 cttgtcaata aacgccaaga aacttctatt ccaggtgttt atgctatcgg tgactgtgca
    53281 actatctacg ataatgctac tcgcgataca aactacattg ctttagcttc aaatgccgtc
    53341 cgtacaggaa ttgtagcagc acataacgct tgtggtacag accttgaagg aatcggtgtc
    53401 caaggctcaa acggtatttc catttacggc ttgcacatgg tatcaactgg tttgacactt
    53461 gaaaaagcaa aacgacttgg ttttgatgct gcagtgactg agtatactga taaccaaaaa
    53521 cctgaattta tcgaacacgg taacttccca gtaaccatta agattgttta cgataaagac
    53581 tcacgtcgta tcttgggtgc tcaaatggca gcccgtgaag atgtgtcaat gggaattcac
    53641 atgttctcac ttgctatcca agaaggcgta accattgaaa agttggcatt aactgatatt
    53701 ttcttcttac cacatttcaa caaaccttac aactacatca caatggcagc acttggtgcc
    53761 aaagactagt atctgatagg aaaaagccag agcagttcag cagcactggc ttttttgctt
    53821 tttaattgtt gcaacctgaa aagttctaaa cttatgatta tcctcttata gcacgttgga
    53881 aaaggaatat caggcaaaac aaaaagagac cgaagtctct tttgtgatta gtttttagca
    53941 gcagaagcaa attcttcctt agcaaaggct tcatcaatga tagctttcaa ttgatttgca
    54001 gaggcttgca ttttttgcaa ttcagcatcg ttaagtggaa tgtttactgg acgaacaatt
    54061 ccatacgctc caacgatagc tggttgacca atatagcaat cttcaacacc ttcgtattgg
    54121 ccttcttgga aaacagaaag cggaagaaca gcattttcat catcaagaat agcttttgta
    54181 atacgagcta gggcaactgc aataccgtag aaagtagcac cttttttatt gatgattgag
    54241 taagcagcat cacgtacaga aatgaaaaga tcaactaggc cttgctcatc aatgtcacga
    54301 ttagcttgga gccagtcgta aagacctaca ccagcaacgt tagcgtgtga ccaaacagca
    54361 aattcagagt caccgtgttc tcccatgatg taagcgtgaa ccgaacgcgc atcaacccca
    54421 attttagcag ctagtgcttg acggaaacgg gctgaatcta gtgatgtacc tgatccaata
    54481 acacgctctt tagggaaacc tgagaatttc catgttgagt aagtcaaaac gtcaactggg
    54541 ttagcagcaa caagaaagat tcctttgaaa ccagatgcaa cgatttgtgt aacaacctct
    54601 ttattgatac gaaggttttt ttcaacaagg tcaaggcgtg tttcacctgg tttttgagga
    54661 gcaccagctg ttaagacaac gagatcagca tcatgacagt ctgagtagtc agctgcatag
    54721 atttttttag gtgatgtaaa agctagagcg tggcttaaat cttctgcatc tccttgagtt
    54781 ttttctttaa aaatatcaat aataccaagt tcttgagcaa tattttgtgt taccaatgca
    54841 aaagcgtatg atgaaccgac ggcaccatca ccgaccaaga ttactttttt gtgttgttta
    54901 gttgcagtca tttctaaaca tctccttaat tttattagag caaaagctca tacggtctta
    54961 ttttaacata ttgataattg tttgtcattg aattcagaaa aataatgaaa atagtttact
    55021 gataacgctt ccaataagaa aaaataagga atttatggta taatgaaacc tagtattgac
    55081 tagaaaagga gcattcctta aatgcaagat cgaaatttaa ttgacgtcaa tctgacaagt
    55141 gaaatgaaaa cgagtttcat tgactatgcc atgagtgtca ttgtggcaag agctttgcca
    55201 gatgtgcgtg atggtctgaa acctgtgcat cgtcgtattc tctatgggat gaatgaactc
    55261 ggtgtgacac ctgataaacc gcataaaaaa tctgctcgta ttacgggtga tgtcatgggt
    55321 aaatatcacc cgcatgggga ttcttctatt tatgaagcta tggttcgtat ggctcagtgg
    55381 tggagttatc gccatatgct tgttgatggg catggcaatt ttggttctat ggatggtgat
    55441 ggtgctgccg ctcaacgtta tactgaagcg cgcatgagta aaattgcgct tgaattatta
    55501 agggatatca ataaaaatac cgttaatttt caagataact acgatggaag cgaaagagaa
    55561 ccagtagtat taccagctcg ctttcctaat ttattagtca atggagcgac agggattgcc
    55621 gttgggatgg caactaacat tccgcctcat aatttggcag agtctattga tgctgtcaag
    55681 atggtaatgg aacatccaga ctgtacaaca agagagttga tggaagtgat ccctggacct
    55741 gactttccga ctggtgccct tgttatgggg cgctcaggta ttcatagggc ttatgatact
    55801 ggtaaaggtt ctatcgtttt acgctctcga acagaaattg aaacaactca aacaggtcgg
    55861 gaacgtattg tggttactga atttccctat ggcgtcaata aaacgaaagt gcatgaacac
    55921 attgttcgtt tagcacaaga aaaaagacta gaaggtatta cagcagttcg tgacgaatct
    55981 agccgtgaag gagtgcgttt tgttatcgag attcgtcgag aggcatccgc gacagttatc
    56041 ttaaataacc tctttaaatt aacaagcctt cagacgaatt tcagttttaa tatgttggct
    56101 attgaaaatg gtgtgcctaa aatattgtca ctcagacaaa tcattgataa ttacattagt
    56161 catcaaaaag aagttattat acgtcgcacc cgatttgata aagataaagc tgaagccaga
    56221 gctcatattt tagaaggctt actgattgcc cttgatcatt tagacgaagt gattgctatt
    56281 attcgtaaca gcgagacaga tgtcattgct cagacagaat tgatgtcacg tttcgacttg
    56341 tctgaacgcc aaagccaagc tattttggat atgcgtttgc gtcgtttgac tggtttggaa
    56401 cgtgataaga ttcaatcaga atatgatgat ttgttggcct tgattgctga cttatctgat
    56461 attttagcca aaccagaacg tattatcact atcatcaaag aagaaatgga tgagatcaag
    56521 cgtaaatacg ctaacccacg ccgtacagaa ttaatggtcg gtgaagtcct ttctctagaa
    56581 gatgaagacc taattgaaga agaagatgtt ttgattacct tgtcaaataa aggttatatc
    56641 aagcgtcttg ctcaagatga atttcgtgcc cagaagcgtg gtggacgtgg cgtccaagga
    56701 actggggtca acaatgacga ctttgtccgt gaattggtat caacaagtac ccatgatact
    56761 ttgctcttct ttacgaattt tgggcgtgtc tatcggttga aagcttacga aattccagaa
    56821 tatggtcgta cagcaaaagg tcttccaatt gttaatctat tgaaattaga agatggtgaa
    56881 accattcaaa ctattatcaa cgcacgtaag gaagaaacag caggtaaatc cttcttcttt
    56941 acaacgaaac aaggcattgt caaacgtaca gaagtttcag aatttaataa tatccgtcaa
    57001 aacggtcttc gtgctcttaa gttgaaagag ggagatcagc tgattaacgt ccttttgaca
    57061 agcggtcagg atgacattat cattggaact cattccggat attctgttcg ttttaatgaa
    57121 gcaagcatcc gcaacatggg ccgatcagct acgggtgttc gcggggttaa gcttcgtgaa
    57181 gatgatcgcg ttgttggcgc gtcacgtatt cgagataacc aagaagttct tgtaattacc
    57241 gaaaatggct ttggtaagag aacaagtgct acagactatc ctacaaaagg taggggggga
    57301 aaaggaataa aaacagctaa tattacccct aaaaatggtc aattagctgg attggttacc
    57361 gtagatggta cagaagatat catggtgatt acaaataaag gtgtcattat tcgcacaaat
    57421 gttgcaaata tttcgcaaac aggtcgtgct actttgggtg ttaaaattat gaaactagat
    57481 gctgatgcta agattgtaac atttaccttg gttcagcctg aagacagtag tattgctgaa
    57541 atcaatactg atcgtgaaaa tagtatttca aaaaataaag ataattaatt ataacaagga
    57601 gtaaaaaatg gtaaaaaaac aaaagcgtcg aaaaataaaa tccatgtctt gggcaagaaa
    57661 actactaata gctgtacttt taattctagg tttagcattg ctttttaaca aacctatccg
    57721 aaatacatta attgctcgaa actctaataa atatcaagta acgaaagttt cgaaaaaaca
    57781 aatcaaaaag aataaagagg ctaagtcaac atttgatttc caggccgtag agccagttag
    57841 tacagagagt gtcttgcaag cacaaatggc ggctcagcaa cttcctgtta tagggggcat
    57901 tgccatacca gagcttggca ttaatttacc aatttttaaa ggtttaggaa atactgagct
    57961 tatttatggc gcaggaacga tgaaagaaga acaagttatg ggaggagaaa ataattattc
    58021 tcttgccagt catcatattt ttggaattac aggttcatct caaatgctct tttcgccgct
    58081 tgaaagagca caaaatggga tgtccatcta tttaacagat aaagaaaaaa tttacgaata
    58141 catcataaaa gatgttttca cggtagctcc tgaacgcgtt gatgttatcg atgatacagc
    58201 tggtctcaaa gaagtgactt tagtgacttg tacagatatc gaagcaacag aacgtattat
    58261 tgtcaaagga gaactaaaaa cagaatacga ttttgataaa gcgcccgccg atgtattgaa
    58321 agcttttaat cattcttata accaagtatc tacctagata tatcttaaat ataatattta
    58381 aaaagtagga ccatagagaa aatttatctc atcctacttt ttttgaaagg agaaatatta
    58441 tgaaactaaa tgccattcat cacgttgcta ttattgtatc tgattataat ctgtcaaaaa
    58501 atttttatgt gaataaactc ggatttgaaa ttatcagaga aaattatcgt cctgacaggc
    58561 atgattacaa attagattta tcttgtggtc gtattgaatt ggagattttt ggtaaggtga
    58621 caagtgaccc ctactatcaa gctcctccta aacgtgtaag tcaaccagaa tttaaaagtg
    58681 aggcctgtgg tttgaggcac cttgcttttc gtgttaccaa cattgagagt tatgtagatg
    58741 atctaaagaa cttaggaatt ccagtggagc ctatcaggca tgatgattac acaggtgaga
    58801 aaatgacttt cttttttgat ccggatggtt tgcctttaga attacatgaa tagtcttatt
    58861 aggttaacga ctggatcgtg ctattaaact cgttaaaaat agttatttgt tgcatcttct
    58921 tttgcttgat taatctcttt taatcgttaa atgatttggt taactttcaa agtgaagagc
    58981 aatttttgga gtaatcttgt cgaagttttt taatagaata actataggaa aagcaaaata
    59041 tttgacga
//
LOCUS       DAUDWO010000005        57158 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.005, whole genome shotgun sequence.
ACCESSION   DAUDWO010000005 DAUDWO010000000
VERSION     DAUDWO010000005.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 57158)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 57158)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..57158
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.005"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..163
                     /locus_tag="VHC05_000265"
     CDS             <1..163
                     /locus_tag="VHC05_000265"
                     /inference="COORDINATES: protein motif:HMM:NF025063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEQ5401612.1"
                     /translation="TLKRELVNDAHFATIEQAQLEIFKYSETYYNPKRLHSALGYLSP
                     VEFEKIVTH"
     gene            complement(260..955)
                     /locus_tag="VHC05_000266"
     CDS             complement(260..955)
                     /locus_tag="VHC05_000266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEQ5401613.1"
                     /translation="MKGFINYLKIAVFIILAMVFNVLPMILLQKQHDIPMVLNWGIGI
                     FYLVIVGSVLIVLWRLYQAKQDTPIKQQKMRLVDWGYLALFWLIIRVIAIVGTLVNQL
                     WSGQQVSANDAAIHTLARLIKGGFPLYTALFVLVIAFIAPIMEELVFRGFPMIDLFKG
                     KSLKVAGLVTSLVFALPHATNSVEFIMYSCMGIFLFVAYQRRGNLKDAILLHIFNNLI
                     EVILLMSIGLGVI"
     gene            complement(974..1735)
                     /locus_tag="VHC05_000267"
     CDS             complement(974..1735)
                     /locus_tag="VHC05_000267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3169 family protein"
                     /protein_id="HEQ5401614.1"
                     /translation="MKKKKNSFLRLLKMLLLSSLAGGIIGGMVGAFLGYHGERLDQLT
                     FLKDDVINLIILLNRLVVVTGLTLSFVFLTQLKKETAVYNTIEEDDISENGYRQLNKK
                     HAYTMLLIAVASILSMCNVLLGLTLTNDSQHAMLAIPLLDILLLLMVIPFQALAMKRY
                     NAIRGTDVPYFPNLKELKHNIMALDEAELQAYHKTSFESVLSLNGVIIPSLYVILFFV
                     YLFTGQVELTAILVLVLIQLYLLVRSATMTRQFYR"
     gene            complement(1732..1947)
                     /locus_tag="VHC05_000268"
     CDS             complement(1732..1947)
                     /locus_tag="VHC05_000268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5401615.1"
                     /translation="MEVILKNRLKELRARDGINQTEMAKLAGVSRQTISLIERNEYTP
                     SVIIAMKIAKVFQEPVEEVFRLVEVEE"
     gene            complement(2307..4925)
                     /gene="alaS"
                     /locus_tag="VHC05_000269"
     CDS             complement(2307..4925)
                     /gene="alaS"
                     /locus_tag="VHC05_000269"
                     /EC_number="6.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000661542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
                     /protein_id="HEQ5401616.1"
                     /translation="MKELSSAQIRQMWLDFWKSKGHCVEPSANLVPVNDPTLLWINSG
                     VATLKKYFDGSVIPENPRITNAQKSIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRD
                     EAIEWGFELLTSPDWFDFPKDKLYMTYYPDDKDSYNRWIACGVEPSHLVPIEDNFWEI
                     GAGPSGPDTEIFFDRGEDFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRS
                     EYKELPNKNIDTGAGLERLAAVMQGAKTNFETDLFMPIIREVEKLSGKTYNPDGDNMS
                     FKVIADHIRALSFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGINETFLYKLVLTV
                     GQIMESYYPEVLEKRDFIEKIVKREEETFARTIDAGSGHLDSLLAQLKAEGKDTLEGK
                     DIFKLYDTYGFPVELTEELAEDAGYKIDHEGFKSAMKEQQDRARAAVVKGGSMGMQNE
                     TLAGIVEESRFEYDTYSLESSLSVIIADNERTEAVSEGQALLVFAQTPFYAEMGGQVA
                     DTGRIKNDKGDTVAEVVDVQKAPNGQPLHTVNVLASLSVGTNYTLEINKERRLAVEKN
                     HTATHLLHAALHNVIGEHATQAGSLNEEEFLRFDFTHFEAVSNEELRHIEQEVNEQIW
                     NALTITTTETDVETAKEMGAMALFGEKYGKVVRVVQIGNYSVELCGGTHLNNSSEIGL
                     FKIVKEEGIGSGTRRIIAVTGRQAFEAYRNQEDALKEIAATVKAPQLKDAAAKVQALS
                     DSLRDLQKENAELKEKAAAAAAGDVFKDVQEAKGVRFIASQVDVADAGALRTFADNWK
                     QKDYSDVLVLVAAIGEKVNVLVASKTKDVHAGNMIKELAPIVAGRGGGKPDMAMAGGS
                     DASKIAELLAAVAETV"
     gene            complement(5312..6367)
                     /gene="prsA"
                     /locus_tag="VHC05_000270"
     CDS             complement(5312..6367)
                     /gene="prsA"
                     /locus_tag="VHC05_000270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase PrsA"
                     /protein_id="HEQ5401617.1"
                     /translation="MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSD
                     FYNETKNTEVSQKAMLNLVISRVFEAQYGDKVSKKEVEKAYHKTAEQYGASFSAALAQ
                     SSLTPETFKRQIRSSKLVEYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNEET
                     AKSVLEELKAEGADFTAIAKEKTTTPEKKVTYKFDSGATNVPTDVVKAASSLNEGGIS
                     DVISVLDPTSYQKKFYIVKVTKKAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIAN
                     ALDKANVKIKDKAFANILAQYANLGQKTKAASESSTTSESSKAAEENPSESEQTQTSS
                     AEEPTETEAQTQEPAAQ"
     gene            complement(6430..7137)
                     /locus_tag="VHC05_000271"
     CDS             complement(6430..7137)
                     /locus_tag="VHC05_000271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="HEQ5401618.1"
                     /translation="MVKSYSKTANHNMRRPVVKEELVHYMRTRQKQTTGFLAELEQFA
                     RQENIPIIQPEVVAYFRFLLQSLQPKHILEIGTAIGFSALLMAENAPDATIVTIDRNR
                     EMIDFAKANFAKYDSRQQIRLLEGDAADILSTLEGNFDFVFMDSAKSKYIVFLPEILR
                     LLRVGGVVILDDVFQGGDITKPIEDIRRGQRTIYRGLQSLFDATLIHPNLTTSLVPLS
                     DGLLMIRKNQADIVLPD"
     gene            complement(7203..8399)
                     /locus_tag="VHC05_000272"
     CDS             complement(7203..8399)
                     /locus_tag="VHC05_000272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OFA family MFS transporter"
                     /protein_id="HEQ5401619.1"
                     /translation="MEKTKRYIIATAGILLHLMLGSTYAWSVYRNPILQETGWDQAPV
                     AFAFSLAIFCLGLSAAFMGNLVEQYGPRLTGTVSAILYASGNMLTGLAIDRKEIWLLY
                     IGYGVIGGLGLGAGYITPISTIIKWFPDKRGMATGFAIMGFGFASLLTSPIAQWLIET
                     EGLVATFYLLGLIYLIVMLFASQLIIKPTAAEIAILDKKRLQNNSYLIEGMTAKEALK
                     TKSFYCLWVILFINITCGLGLISVVAPMAQDLTGMSPEMSAIVVGAMGIFNGFGRLVW
                     ASLSDYIGRRVTVILLFLVSIIMTISLIFAHSSLIFMISIATLMTCYGAGFSLIPPYL
                     SDLFGAKELATLHGYILTAWAIAALTGPMLLSITVEWTHNYLLTLCVFIVLYILGLMV
                     ALRLKK"
     gene            complement(8775..10580)
                     /gene="pepF"
                     /locus_tag="VHC05_000273"
     CDS             complement(8775..10580)
                     /gene="pepF"
                     /locus_tag="VHC05_000273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HEQ5401620.1"
                     /translation="MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFA
                     GHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKNDQDTTVAKYQEYQAKASGLYAKF
                     SEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
                     QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAM
                     YSTYEQFQHTYAKTLQTNVKVQNYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNK
                     HLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALEKAEKVLAVFGKDYA
                     DRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSL
                     HSTFTRETQPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFR
                     GTVFRQTQFAEFEHAIHQADQKGEVLTSEYLNQLYADLNEKYYGLSKKDNHFIQYEWA
                     RIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPLEVIAKA
                     GVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS"
     gene            complement(10593..11555)
                     /locus_tag="VHC05_000274"
     CDS             complement(10593..11555)
                     /locus_tag="VHC05_000274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein CoiA"
                     /protein_id="HEQ5401621.1"
                     /translation="MTKILTALDGKNQLISLVTQPISTKPPFRCPACKSPVRLRQGTI
                     RRPHFAHVQLAHCQFQAENESEEHLTLKAKLYTSLVRTEAVCIEKYLPELQQIADLWV
                     NDKLALEIQCSPLPVERLKKRTKAYQEKGYPVRWLLGRKLWLNTHLTALQKQFLYFSS
                     SLGFHLWELDAAANLLRLKYLIHEDLFGKVSYLTKTISLDHNIMEMFRLPYQQEILYS
                     YQKKMTVNLSKRIQRALLARHPKWLRRQEKAYLSGYNLLMLTTDAFYPQWRPVQSSSG
                     FCQIKGNLRPYYESFKVYYKKEKDKKVQTLFSPKYYVKMDSNRK"
     gene            complement(11850..12566)
                     /locus_tag="VHC05_000275"
     CDS             complement(11850..12566)
                     /locus_tag="VHC05_000275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEQ5401622.1"
                     /translation="MRLDKLLEGTKVGSRSQVKKLIKAQGVWVDHMPARNGRQNVDPG
                     LQLIEVTGQRVTHPKHSYIILNKPSGVVSAKKDTNYLTVIDQLAEEDKSPDLYPVGRL
                     DRDTEGLVLLTDNGPLGFRMLHPIHHVSKTYLVTVNGLLAEDASDFFAAGICFPTGEQ
                     CQPAQLTILKADTDQSQASLTISEGKFHQVKKMFLTYGLKVTSLKRTHFAGLELGHLA
                     SGEYRYLTESERQLIKTYLD"
     gene            complement(12685..13389)
                     /gene="nagB"
                     /locus_tag="VHC05_000276"
     CDS             complement(12685..13389)
                     /gene="nagB"
                     /locus_tag="VHC05_000276"
                     /EC_number="3.5.99.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012679214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HEQ5401623.1"
                     /translation="MKIIRVQDQIEGGKIAFTLLKDSLAKGAKTLGLATGSSPISFYQ
                     EMVKSPLDFSDLTSINLDEYVGLSVESDQSYDYFMRQNLFNAKPFKKNYLPNGLATDI
                     EAEAKRYNQIIAEHPIDFQVLGIGRNGHIGFNEPGTSFEEETHVVDLQKSTIEANSRF
                     FTSIEDVPKQAISMGIASIMKSKMIVLLAFGQEKADAIKGMVFGPITEDLPASILQKH
                     DHVIVIVDEAAASQLD"
     gene            13591..14619
                     /gene="queA"
                     /locus_tag="VHC05_000277"
     CDS             13591..14619
                     /gene="queA"
                     /locus_tag="VHC05_000277"
                     /EC_number="2.4.99.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="HEQ5401624.1"
                     /translation="MNTNDFDFELPEELIAQTPLEKRDSSKLLIIDHRQKTMVDSHFD
                     HIIDQLNPGDALVMNNTRVLPARLYGEKPDTHGHVELLLLKNTQGDQWEVLAKPAKRL
                     KVGSQVNFGDGRLKATIIDELEHGGRIVEFSYDGIFLEVLESLGEMPLPPYIHEKLKD
                     AERYQTVYAKENGSAAAPTAGLHFTTDLLKKIEAKGVHLVYLTLHVGLGTFRPVSVDN
                     LDEHDMHSEFYSLSEEAAQTLRDVKQAGGRVVAVGTTSIRTLETIGSKFQGDIQADSG
                     WTNIFIKPGYQFKVVDAFSTNFHLPKSTLVMLVSAFAGRDFVLEAYRHAVDEKYRFFS
                     FGDAMFVN"
     gene            14626..15846
                     /locus_tag="VHC05_000278"
     CDS             14626..15846
                     /locus_tag="VHC05_000278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3114 domain-containing protein"
                     /protein_id="HEQ5401625.1"
                     /translation="MKLLGKWLFFLMFLTFCVSFWQKDYQRIAFEKEHKLYQDLVAPF
                     YQNYPKLRELQLSEAIKLRHDLLDYVRKLDKDGWSYKAIQKGYLEQLAVRGNSYHFEQ
                     LYSRIRLIGSPDFQKLWQQEEMAQTPQEAQKRLQLLLTYLKMPDELTGQSKQTQQVLA
                     QLSPKLSPTDPFWDQLSALIQACYVNLEHIPYSRFNRKIHQLRYLISTQQMEWVRSHY
                     GNKGKTDADALAKYLATLEDDDYALYESSRYHNKVASILDANGNHQAVYTDNIPQANY
                     KILIHFHSEFILSESGQFLVALDPDNLTRNSIVNGSSFNYGNQNDDLHRLLDIDPILL
                     FDPAFIEKATNSPDATFLVPDLEQQRDKHNPIYSRNGKSSKQLTRAAVKKFKKLLHHY
                     QETRGDNKTSKTQH"
     gene            complement(15960..16550)
                     /locus_tag="VHC05_000279"
     CDS             complement(15960..16550)
                     /locus_tag="VHC05_000279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase"
                     /protein_id="HEQ5401626.1"
                     /translation="MTERFDITETDYEYDQEHHAYVAQFNGAMSIPDMQEYSLVYSEN
                     TPAYALAERLGGMNKAYQLFDRYGKVSGAITTIDRNGNKITTAYYLQVLDYLWQHQDK
                     YKDILYYIGESFPDLYYKTYLPHVKVYQKPGYVREALNVGAIVCEESPYLIALYSSGL
                     GGATQASEEVNGLGYVQLVQLPYVINEWHRVNHNMI"
     gene            complement(16547..16795)
                     /locus_tag="VHC05_000280"
     CDS             complement(16547..16795)
                     /locus_tag="VHC05_000280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401627.1"
                     /translation="MDTDLVQMDALGLYYDDNHLSLVNTVKAYLKEFGIGESQIAFSY
                     KDLNSGRTVAMNDHQPMIAGSTYKLPLNMLVVDKANYP"
     gene            complement(16780..16997)
                     /locus_tag="VHC05_000281"
                     /pseudo
     CDS             complement(16780..16997)
                     /locus_tag="VHC05_000281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922433.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(17164..17769)
                     /locus_tag="VHC05_000282"
     CDS             complement(17164..17769)
                     /locus_tag="VHC05_000282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="HEQ5401628.1"
                     /translation="MAIILPELPYAYDALEPQFDAETMTLHHDKHHATYVANTNAALE
                     KHPEIGENLEELLADVTKIPEDIRQALINNGGGHLNHALFWELLSPEKQDVTPDVAQA
                     IDDAFGSFDAFKEQFTAAATGRFGSGWAWLVVNKEGQLEITSTANQDTPISEGKKPIL
                     ALDVWEHAYYLNYRNVRPNYIKAFFEIINWKKVSELYQAAK"
     gene            complement(17866..18906)
                     /locus_tag="VHC05_000283"
     CDS             complement(17866..18906)
                     /locus_tag="VHC05_000283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HEQ5401629.1"
                     /translation="MIAIEKIEKLSKENLGLITLVTGDDIGQYSQLKSRLMEQIAFDK
                     DDLAYSYFDMSEAAYQDAEMDLVSLPFFAEQKVVIFDHLLDITTNKKSFLKEKDLKTF
                     EAYLENPLETTRLIIFAPGKLDSKRRLVKLLKRDALVLEANPLKEAELRTYFQKYSHQ
                     LGLGFESGAFDQLLLKSNDDFSQIMKNMAFLKAYKKTGNISLTDIEQAIPKSLQDNIF
                     DLTRLVLGGKIDAARDLIHDLRLSGEDDIKLIAIMLGQFRLFLQLTILARDVKNEQQL
                     VISLSDILGRRVNPYQVKYALKDSRTLSLAFLTGAVKTLIETDYQIKTGLYEKSYLVD
                     IALLKIMTHSQK"
     gene            complement(18977..19558)
                     /locus_tag="VHC05_000284"
     CDS             complement(18977..19558)
                     /locus_tag="VHC05_000284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEQ5401630.1"
                     /translation="MRTHTDTDHMGDIEVVAKAIRIKEILTSQGSLSHPSFVRRLRRL
                     KCHVRVLAAGDQLPIMGSVLQVLYPWQLGDGKNNDSLVLYGRLLNRTFLFTGDLEKEG
                     ENEIIKRYPQLRVDYLKAGHHGSNTSSSAAFLDHIQPKVAFISAGKNNRYQHPHRETL
                     ARLEDRQITYYRTDTQGAIRLTGWTSWHLETVR"
     gene            complement(19632..20207)
                     /locus_tag="VHC05_000285"
     CDS             complement(19632..20207)
                     /locus_tag="VHC05_000285"
                     /inference="COORDINATES: protein motif:HMM:NF015461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ADP-ribosyltransferase"
                     /protein_id="HEQ5401631.1"
                     /translation="MNEFCYKLKGKILRTGQKWDLLSSSQADVPLFVAKYLNNEPPRY
                     VGKIPSDEYIIASSGPTINGRLRSGSVDEKIENIYQTLKKYSTKADIVVYRGVSMETL
                     EKMVESAQVEGCIDFKEKGFLHTSLVKGFEFRDPYKKLRIKIPKGTNAFYVGNLNNEE
                     THYYEVIIQKGAKLKVISIDDYINCELVGTD"
     gene            complement(20263..21828)
                     /locus_tag="VHC05_000286"
     CDS             complement(20263..21828)
                     /locus_tag="VHC05_000286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017771979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEQ5401632.1"
                     /translation="MKNVITIEANAPRNSELASISLPKKRRVAGYARVSTDHEDQTTS
                     YESQMRYYAEYISTRSDWEFVKMYSDEGISGTNTKLRVGFKSMIEDALAGKIDLIITK
                     SVSRFARNTVDSLTTVRKLKEVGVEIYFEKENIWTLDSKGELLITIMSSLAQEESRSI
                     SENVTWGLRKQFAEGKVHFPYTNVMGFEKGENGEIVVNQEEAKTVRYIFQQALLGKTP
                     YSIAKDLTQQGILSPSGKNHWSSVTIKRMLRNEKYKGDALLQKTYTIDFLSKKKNINK
                     GELPQYYVENNHEAIVDKETFDAVQASLDRKEKGKGSTTLFSSKLVCGDCGHYFGSKV
                     WHSTSKYRRVIYQCNEKYKGEKKCTTPHVTEDEIKDWFVTAINKVISNKDEIIQNLEM
                     LLDVGESSDLERRLVELETEVEVVTQMVSNLVKENAIMPQDQDTYQKKYSNLVERHDA
                     LVSEIESIEKQLLEAASHQKDLKEFLKTLNQQSELISEFDELLWETMVDEIKIFCDQT
                     VAIKFKNGIEVVE"
     gene            complement(21825..23063)
                     /locus_tag="VHC05_000287"
     CDS             complement(21825..23063)
                     /locus_tag="VHC05_000287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEQ5401633.1"
                     /translation="MRIVRRIQPMMTPQKPKLRVAAYARVSDSRLHHSLSTQVSYYSR
                     LIQSHPDWELVGVYYDEGISGKEQSNRQGLQDLLKACDDGKIDRILTKSIARFGRNTV
                     DLLSTVRVLRQKNIGITFEKEGIDSLSSEGELMLTLLASVAQEESHNISENLRWQIKK
                     KFEQGQPHTPQDIYGYRWNGENYVIEPDEAKVVRQVFQWFLDGDNAPMITKKLNEQGV
                     LTRLGNPFTVSSVREFFKQEAYFGRLVLQKTYREPFSRNPKRNNGQKNKYIVEDAHEA
                     IVSKSYFDVVLQEKERRYKVMYQESHMHKGTFRELIECSHCGKIMITRVDSKKVHRTI
                     RYCCRTRDRFGTSSCPSKTLSEKRILATFEDKIGFKPDKNWVTENIKKVIYDSSVGLI
                     TVFPIKGRKYELKVRKEHFL"
     gene            complement(23121..23282)
                     /locus_tag="VHC05_000288"
     CDS             complement(23121..23282)
                     /locus_tag="VHC05_000288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017643178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401634.1"
                     /translation="MTNDKLQDEMTYQLTMIQADRLLKSRIISEEVHQQFKEKMLEKY
                     QPFISRLST"
     gene            complement(23388..24164)
                     /locus_tag="VHC05_000289"
     CDS             complement(23388..24164)
                     /locus_tag="VHC05_000289"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEQ5401635.1"
                     /translation="MTSKEKVVANALSKVNTKVTVPTNPYGGQCVALIDKIVQEETGK
                     NMSYTNAIDCLDKAKANGFQVTYDAVGVNPQAGDFYVIRVPSHSFGHIGVCLADSDGT
                     GLEGVEQNVDGYSDSNRNGVNDQLEVGGYTRRVSRKWYSDGRLVDSHSGGLVGYMVGW
                     FRLPYEVATSTKKVETSEDEDMKNFVVRSKSGKQGYVAVVNGAVFGIGHIDTVVQLQS
                     AGAAHLTLDDGDFNRFLESQKFDDEKLVASVQALEKAIKQ"
     gene            complement(24154..24570)
                     /locus_tag="VHC05_000290"
     CDS             complement(24154..24570)
                     /locus_tag="VHC05_000290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin family protein"
                     /protein_id="HEQ5401636.1"
                     /translation="MKQEVLTNKLVFSGIGGVIGSIFGEIDGFLYGLLIFMLIDYVTG
                     IMAAIVEKNLSSSIGKKGIFKKAMIICLVAVAHMIDLHVLKQGGAVRTAVIFFYFSNE
                     GLSILENATRIGLPVPNRIKQVLRQLNEDKEDENDK"
     gene            complement(24581..26437)
                     /locus_tag="VHC05_000291"
     CDS             complement(24581..26437)
                     /locus_tag="VHC05_000291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000796407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401637.1"
                     /translation="MADYGSNNDRGYNLLLRVEETGTSTANNTSTVRVQLWLRNGQTT
                     FGMYNCSASVSIDGQTLSWSGRPDMYSMNSSLHLIDKTITIAHNSNGQKTIGFSATFS
                     GSGGWSPGTLNTGYQSLRLRDIPRSSTASVSGNMMGSPITISITRASGDFTHKVTWQF
                     GSLSGVVATGATTSCSWTPEVAKLAPQIPNATSGIGTILVQTIYGGKVIGESRIQVTL
                     QLPSSVVPSLSSISLSDLNTIAQNAITGNTFVSLESNPKVTFNGATGIYGSTIPASGY
                     RAEVFKFEGNSWIQLQNVATAQNGGVGGINHVGRAKISAFVTDSRGRQSPRKEVEISL
                     LEYFKPILSFTSVRVGTTMNQLNVIRKVKIAPLIVGNSQKNRATMTWDILDLSTGTKT
                     TNVGGAANWSTTTEHTKENFQATLNGTYDQTKSYTIIGHLRDLFYETDFEFTVGPEKV
                     VYGLSPTGMGIGKAWTRGVLDVDGSQPSYFDGDIIMRNKKLIDIFYPIGTIYESTSSE
                     SPSTFMGGKWERFGNGRVLVGVSETESEFNTVSKTGGSKTHTLTINEMPVHSHPQYVS
                     ANSGNQATRRDYSSDGSSSLYPQGNNTGNSGGGQAHNNLQPYITVYRWRRTA"
     gene            complement(26450..29338)
                     /locus_tag="VHC05_000292"
     CDS             complement(26450..29338)
                     /locus_tag="VHC05_000292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017650699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEQ5401638.1"
                     /translation="MLFLLDGQTKTPKWNGFPLHETLSAEVEETLNGDFTLQFDYPIT
                     DSGIYKELVTDKLILCPVPYVKKQLFRIKKPVEENDRVRVTCQHITDDIMRRSILPVS
                     NQNVTCQSALGQLISKAKRDIAPFSFDSDITKKRSFNTTETATLYQVLMDGKHSILGT
                     WEGELVRDNFLFTIKEHRGKNRGVVISTHHNLEKFDRTRSSQSIVTRIYASSIFKPEG
                     EKEEKTLSVMVESPLIHQYPYVHEAEYENNNLHTEEELRQWAMAKFSNDHLDQVSEVI
                     EIEAFELDGQEVQLGDEVTLKSRLHQVDVVKRAVGYRFNALTEQITSISFDDTVAFGG
                     QGVSGNPISSVANELLTLNDGKIQRQIERERANLSRVLDFNMSRVNKDVEDGIERAKA
                     EAIRSGNQAAVDYLSSEAAEIRFAAIQKAKIDELTVSNSAWMRRLVSHQVLTEYLNAI
                     EVNANKVVIPGSHKPVFSLDSNGNISIDTPLLKVRGEELATKSQLSKLSLTPGPKGDK
                     GVSISQIEEYYLASNQKTGVLTSTSGWSKTIPVLTDTIKYLWNYKRTVFTDGNETSTT
                     PVVIGVYGNKGDTGQTLYTWKMYADSEKGEGISPSPKGKRYFGLAVNRPTATPSTNPS
                     DYTWSSFFEGTVLGGRNYIDDYAMRETSFTNLQSEWRKEIVEDSTSVSGISIKMTCTK
                     AGSGGFKRDFFDLRTRIGQTMTFSVELKASRAVSMMIGSELGGTKPVSLTANWERVVS
                     SWKVSSNSTWSFVFTLSSGAWAQGDVVWLRNVQLEDGNVATAPGPSLADLMKQIDGKA
                     DQSFMKQQLDILTEKTESIRVDMEARALASEVSDWLKTYKEFEKSNKETLTKFNQDFV
                     TNTQRIAAIEADLKSNALLLQFVNTYLRAGDNGVIIGKKDNSEFIELTPQGMMIKSAG
                     NAVMTVTSGVIKIHHGVFVETLQVGYYRLEAARHNPKHLVCRFIDSKT"
     gene            complement(29338..30063)
                     /locus_tag="VHC05_000293"
     CDS             complement(29338..30063)
                     /locus_tag="VHC05_000293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEQ5401639.1"
                     /translation="MIQHNALIIDGVSTASFPYKILVEDRPSFHIPTSKSQLQEHDGL
                     SGGLVLTNKHRKAIEKAYRIHLIGATEEQINEFSALLTREGFWLESERMKMTRYWCYK
                     VDSFDIVQDNLGVFSMEVTFLCHPTRYFKKVSEYTLTKNGMIPLLGSALSYPKITVSG
                     KSTGETSFTIGEQVIGLEQLNKTLVMDNDPSHPSFLTESGELVHWSGDFITLDANQKD
                     KKVGVVLGTGITSLHIEILWGWT"
     gene            complement(30060..33179)
                     /locus_tag="VHC05_000294"
     CDS             complement(30060..33179)
                     /locus_tag="VHC05_000294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000918338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tape measure protein"
                     /protein_id="HEQ5401640.1"
                     /translation="MAGNIKGITIEIGGDTQPLQRALKGINKESAESTKELKQIDKAL
                     KFDTGNVTLLTQKQEVLSKQIATTKEKLETLRQAQSQVEAQFQRGDIGAEQYRAFQRE
                     VETTQNVLKSYETKLEGVNRALDSHGNTVESNRSKLNSLEAEQAQLASESEKLNSTFR
                     LQESQLGSNASESEKLALAQRRIASQSELVERQIANLERQLELTKSEYGENSVEANRL
                     EKTLNDTKTAYNNLQQEMEGLSNASQQSAASLEQTNGLLKADILMEFGDRLGELSQKL
                     IEFGQQSLEAFREVDEGMDIIITKTGASGKALEGMQDIATELATSIPTDFATAGSAVG
                     ELNTQFGLTGDALSQASALLIKYSEINGSDVTQSAISAKQAIEAYGLESKDLAMVLDT
                     VTFTSQQTGVGVQDLMSKVVSGAPQIKSLGLSFDEGVALMGRFEKAGVDSSAALSTLS
                     KAAVNYAKDGLTLQDGLAKTVEQIKNSTNETESLTLASEVFGSKAAPRMVDAIKRGAF
                     SFNDLSGTAKNALGVVTSTYEATLDPIDKFTIAQNTAKAAMAEVGGVLAEALAPVLEL
                     LAQLLQAVANWFSNLPGPIQTFIVIMGGLITVVGLLLPGLLALQAAAVAMGTTIGGLV
                     VAAAPIVGTVLGIIAVITLLVVWIQELWQNNEGFRTAVIEIWNAIYAFISVIIQEIST
                     FIMTIWGTLTTWWTENQALIQAAVETVWNAISTVIQTVMSLIGPYLEAAWANIQLIIT
                     TAWEIIKTVVETAITVVLGIIKAIMQAITGDWSGAWETIKGVLQRVWQAIQQIVTTIL
                     SAIGQFISNTWNGIKNTISNILSAISGIVSSIWNTIKSVISSVISSIVSFVSSGWSGI
                     QQTISSILSGISSTVSSVWNGIKNSISNAINGAKNVVSSAINAIKNLFNFKISWPHIP
                     LPHFSVSGSANPLDWLKGGLPKISIAWYAKGGILTKPTAFGMNEKQLMVGGEAGKEAV
                     LPLTKQNLAAIGEGIASTMGTGGNFINVSITDVVIREEADIKRLANQVAERIHDELTR
                     QQSLRGVTL"
     gene            complement(33358..33777)
                     /locus_tag="VHC05_000295"
     CDS             complement(33358..33777)
                     /locus_tag="VHC05_000295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401641.1"
                     /translation="MRKQVTICGKVYPLASNAYTPIAYKEQFGKDYFQDLFQMINAKS
                     ILDQLNQLEEGEELTAQNMDVSILSDFDMTFFHRLFWVFAKSANPRVKAFDVFFMEME
                     ELPIQEIGPVLMEMLNQGMSTRKKSMKPMKRVKKSSR"
     gene            complement(33774..34364)
                     /locus_tag="VHC05_000296"
     CDS             complement(33774..34364)
                     /locus_tag="VHC05_000296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017770803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEQ5401642.1"
                     /translation="MAEKNKVTFGLQDVHWAEVTTEGSDGALTYGNVERLRGAAELTL
                     EATGDSGSYKADNINFYTTESNDGYSGTLKVALLTQEFLTRVLGETLDDTNKVITESS
                     NATRKNFALMFRFEGDKKETLHVLYYCYASRPTVGSKTKNGSDINEVELKFTASPRPL
                     DQVVRRRTTEETPETVKKNWFKSVYEPTVASGGSRT"
     gene            complement(34377..34694)
                     /locus_tag="VHC05_000297"
     CDS             complement(34377..34694)
                     /locus_tag="VHC05_000297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401643.1"
                     /translation="MSEKEFFKQLKALHLPIAYHHFEEGHSPSPPFMVYYSPQSENFG
                     ADNQVYHKGAQFILELYTRKKDLDVEGKIETFLTEQHLFFDKVETYIDTEQLYQVAFH
                     FAF"
     gene            complement(34691..35050)
                     /locus_tag="VHC05_000298"
     CDS             complement(34691..35050)
                     /locus_tag="VHC05_000298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018369002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HK97 gp10 family phage protein"
                     /protein_id="HEQ5401644.1"
                     /translation="MRADELSRAIEKELEEYLHQTTETVVEAVDDVTDEAIATLKSTS
                     PKRSGRYVRGWTSKETSSTSTGKTKTIHNRTPGLTHLLENGYAKQNGGRVSGRPHIGP
                     VEQKAVQALEKKIRGNL"
     gene            complement(35047..35376)
                     /locus_tag="VHC05_000299"
     CDS             complement(35047..35376)
                     /locus_tag="VHC05_000299"
                     /inference="COORDINATES: protein motif:HMM:TIGR01563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage head closure protein"
                     /protein_id="HEQ5401645.1"
                     /translation="MKIAPLNQRVLFKKRVITQDDIGNETSQFTNLFSRWASVNQANS
                     DEIFEVGQTKRKLQLIVTLRYDSEVASLDTTNTQLIFQGKSFNILSIDHVFFEKKMVK
                     CRVEEEP"
     gene            complement(35377..35640)
                     /locus_tag="VHC05_000300"
     CDS             complement(35377..35640)
                     /locus_tag="VHC05_000300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage gp6-like head-tail connector protein"
                     /protein_id="HEQ5401646.1"
                     /translation="MLTLLEAKIYLRVDTSEEDNLIKVLIATSEELCKDVLRVDELVD
                     TPLIRSAMLYAVAYLFEHREEANHHDLKETLYHLLGGLRKEVF"
     gene            complement(35644..36831)
                     /locus_tag="VHC05_000301"
     CDS             complement(35644..36831)
                     /locus_tag="VHC05_000301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage major capsid protein"
                     /protein_id="HEQ5401647.1"
                     /translation="MDKILELREKRAKVWDKAKNFLDSCRDEKGMISQEDSEHYDKLE
                     QEVVDLGKEIDRLERQERIERELSQATSAAIVSQPRTDAGGDEKTGTASTVYNQSFWK
                     NVRQKNFFDVNNTLNIGNDGQGGYLVPDEYENRLIKALEEENFFRRLATIIKTSNGER
                     KIPVVTGHGTAAWMDENGTYPESEETFGQVTLGAYKVGTAIKISEELIHDSVFDLESY
                     MAEEFARRIGSKEEEAFLIGDGSGKPTGVFTTVTEGVTSTGANITFDDVMDLYHSLKS
                     PYRKNSVWILNDSTIKALRKLKDNNGNYIWQPSVQAGVPDMILNRPYYTSSYAPEIAS
                     GQKVLAFGDFSHYWISDRQGRSFKRLNELYATSGQVGFLGSQRVDGKLVLPEAVKVLT
                     MKG"
     gene            complement(36847..37533)
                     /locus_tag="VHC05_000302"
     CDS             complement(36847..37533)
                     /locus_tag="VHC05_000302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003084543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Clp protease ClpP"
                     /protein_id="HEQ5401648.1"
                     /translation="MHKFWNWAKNEGERTLFLNGVIASESWFGDEVTPQLFKDELLSE
                     QGDITLWINSPGGDVFAAAQIYNMLMDYKGAVTVNIDGIAASAASVIAMAGTIVNMSP
                     VSMMMIHNPATFASGDKREMEKAIQLLNEVKESIINAYEIKTSLSRQKLSNLMDGETW
                     LNAKKAVELGFADQIIFDGTHDNDESQDAYAFSMQTVTNQVVAKCEQLIDKPKVAVST
                     LEKRLQLLKP"
     gene            complement(37526..38767)
                     /locus_tag="VHC05_000303"
     CDS             complement(37526..38767)
                     /locus_tag="VHC05_000303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HEQ5401649.1"
                     /translation="MGILELIGLKRARDKPTNSYEGSDFSYLFGRTTSGKNVNEMTAL
                     QTTAVYACVRILAEAIASLPIHVYKHTDEGKEQDVNHQLYYLLHDEPNPDMTSFVFRE
                     TLMSHLLIWGNAYAQIIRDGRGQVLALYPLLPDRMTVKRDDKGELYYVYQRSEEDNPN
                     FKDKGNIILKKSEVLHVPGLGFDGLIGYSPIAMAKNAVGMTLATEEYGASFFANGANP
                     GGVLEHPGILKDPSKVRESWNQVYQGTNNSHKVAVLEEGMIYKTIGIPPNEAQFLETR
                     KFQINEIARLYRIPPHMVGDLEKSSFSNIEQQSLEFVKYTLDPWVVRFEQAFQKALLL
                     PDEKKTYFIKFNVDGLLRGDYQSRMNGYAIGRQNGWLSTNDIRRLEDMNPLSKEEGGD
                     LYLVNGNMTKLEDAGGFIKDA"
     gene            complement(38779..40371)
                     /locus_tag="VHC05_000304"
     CDS             complement(38779..40371)
                     /locus_tag="VHC05_000304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006268711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="terminase large subunit"
                     /protein_id="HEQ5401650.1"
                     /translation="MTYHYKPSPFMLPTSHYDEKKADRAVAFIQNLKHTKGKWAGKHF
                     LLLPWQEQIIRDLFGIVKEDGNRQFLSAYVEIPKKNGKSELAAAIALYLLYADGEASA
                     EVYGAACDRNQASIVFDVAKQMVGMSNPLNKRSKIMGATKRIVNYNNAGFYQVLSAET
                     GTKHGLNVSGLVFDEIHAQPNRHLYDVLTKGSGDAREQPLFFIITTAGTDKNSICYEL
                     HTKALDILSGRKKDETFYPVVYGLANDEDWQDEENWYKANPSLGHTIQIDRVREAYRN
                     AIDNPAEENVFKQLRLNMWTSSTVTWIAEHVYDKGNRPIVESSLLGRECYAGLDLSST
                     SDITAFVLVFPPRTEDESYIVLPYFWLPEDTLPLRCRRDHVLYDVWERQGYLKTTEGN
                     VVHYGFIERFIEDLSTKFNIKEIAYDRWNATQMVQNLEDMGLTVVPFGQGYKDMSPPS
                     KELYKLMMEGRVTHAGHPVLKWMAQNVVMRQDPAGNIKPDKEKSVDKIDGIVALIMGL
                     DRCIRHKGDDGSIYDQRGILSF"
     gene            complement(40373..40840)
                     /locus_tag="VHC05_000305"
     CDS             complement(40373..40840)
                     /locus_tag="VHC05_000305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001007670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage terminase small subunit P27 family"
                     /protein_id="HEQ5401651.1"
                     /translation="MAQRGRKPKPTGLKVLEGNLGKRPLNHKEPKPTKKAPRCPSWLE
                     EDAKKEWKRMSKVLESMGLLTDMDMTAFAGYCQAYARWKEAEEFLTKHGSIIKTPNGY
                     LQQVPQVSIAQTNMKIMLKFSEQFGLTPSARSRIQADSSDGEQDEMESLLREV"
     gene            complement(40906..41155)
                     /locus_tag="VHC05_000306"
                     /pseudo
     CDS             complement(40906..41155)
                     /locus_tag="VHC05_000306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006740232.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(41462..41674)
                     /locus_tag="VHC05_000307"
     CDS             complement(41462..41674)
                     /locus_tag="VHC05_000307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017770792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4314 domain-containing protein"
                     /protein_id="HEQ5401652.1"
                     /translation="MNNGAKERVECLYPVGCRVKLLEMDDPFPPPIGTLGTVYGHDDL
                     ASVLVHWDNGSGLSVVYGVDRIVKVE"
     gene            complement(41737..43005)
                     /gene="dcm"
                     /locus_tag="VHC05_000308"
     CDS             complement(41737..43005)
                     /gene="dcm"
                     /locus_tag="VHC05_000308"
                     /EC_number="2.1.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017770791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /protein_id="HEQ5401653.1"
                     /translation="MNQLTFIDFFAGIGGFRRGLELAGMTCIGYCEKDKFAVRSYQAM
                     YDTEGEWYSDDITKLKPNDIPKADIWTAGSPCQNVSIAGKRAGLRAERSGLFFTLVDL
                     LKSQSEEDKPEWLILENVKGLLSSRRGVDFLDYLLELDEAGYDLEWQVFNSKDYGVPQ
                     NRERVYTIGHLRSRGRRQVLPLQPESSGNLKQLVGGMQSYRVYDTDGISTTLVGTGGG
                     VGAKTGLYLIDQSTTKPKVTDQARCITARYTAGSTKRTAMNSGVMEVQPILTPDRVNK
                     RQNGRRLKEKGEPMFTLTSQDRHGVVEGIKVRNGTKQGYQVAELGDSVDLSYPASPTK
                     RARVGKGIAHNLSCSGQMGVVVWNGRMVKIRRLTPRECFRLQGFTDDLFEKAQAVNSD
                     AQLYKQAGNGVTVTVVYAIGKAILSCLNLR"
     gene            complement(43002..44252)
                     /locus_tag="VHC05_000309"
     CDS             complement(43002..44252)
                     /locus_tag="VHC05_000309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002904805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA modification methylase"
                     /protein_id="HEQ5401654.1"
                     /translation="MMTKESMTWLTLTVDQLNSASYNPRKALKKGDKEYEKIKRSIQE
                     FGYVEPIIVNYDMTIIGGHQRLTVLKDLGFKEVQCVQVHIEDENKVKALNVALNKITG
                     SWNEELLADLMLDLQEADFDTDLTGFEFPEIDQLFSKVHNKEVNEDDFDVDEELKKPT
                     VAKQGDIWYLGKHQVICGDSTLPETYITLMGDKKANLVLTDPPYNVNVEETAGKIKND
                     NMSDSDFYKFLFAMFVNVEQNMESDASIYVFHADTEGYNFRKAFKDAGFYLSGCCIWK
                     KNSLVLGRSPYQWQHEPCLFGWKNKGKHQWFSDRKQTTIWEYDRPKLSKEHPTMKPIQ
                     LMAYPIQNSSMRGTVVLDPFLGSGSTLIACEETGRICYGIELDEKFVDVIVKRYFEAT
                     GDQSIKVMRDGKEIKYADLVEVSV"
     gene            complement(44249..44653)
                     /locus_tag="VHC05_000310"
     CDS             complement(44249..44653)
                     /locus_tag="VHC05_000310"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEQ5401655.1"
                     /translation="MNDFKAKQVWKMRNEGLGYRKIANLLDLSLTAVKRYCSTNPHLK
                     GYGQAVVAMISDGQRNGQLCKECLKPIEQPRKGRTKQFCSDSCRRKNWVTQHPEKADS
                     HVCELCGKTFTAYGSPRRKFCSRTCARTPRRT"
     gene            complement(44901..45266)
                     /locus_tag="VHC05_000311"
     CDS             complement(44901..45266)
                     /locus_tag="VHC05_000311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HNH endonuclease"
                     /protein_id="HEQ5401656.1"
                     /translation="MPRRPSTPCKQNGCPNLVPYGHKYCDNHKANYQLDTKSTKAKGY
                     NAQWNKARLRYLKVQPLCVQCKVKGRLTKATVVDHITPHRGDQDLFWNQTNWQALCKS
                     CHDRKTKTTDRYVEYTYRF"
     gene            complement(45268..46305)
                     /locus_tag="VHC05_000312"
     CDS             complement(45268..46305)
                     /locus_tag="VHC05_000312"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003058380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HEQ5401657.1"
                     /translation="MIISSEQVSVGHPDKICDQISDAILTECLKYDKSSRVAVETLIK
                     DNQVVVAGEISTRHYFNLENIVRQVVEPLGMKNVRVTNLLGLQSSDIAQGVDNGGAGD
                     QGMMFGYATDETPEYLPLPYVLATRVLEKLMSLGHPLLGKDAKAQVSYDYEKKRIDTF
                     LVSIQHTEIANLAKVKRIVTEAMMSVALRYRQNLDFKVLVNPTGRFVLGGSFADAGVT
                     GRKIVADTYGGFAHHGGGAFSGKDPSKVDRSAAYMARKIAKDIVREGYAKRCEVQLAY
                     AIGVAEPVSVYVETFGTSRYTSTQLEGMIRERYDLTPQGIIKELHLLNVDYTKTSCFG
                     HFTKAYLPWEK"
     gene            complement(46353..46535)
                     /locus_tag="VHC05_000313"
     CDS             complement(46353..46535)
                     /locus_tag="VHC05_000313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401658.1"
                     /translation="MTKRQQEKLNALLTEIAKEELFVETLEKRWSDNLDFYDVSVWGI
                     KRALERAYEAGQKSVK"
     gene            complement(46624..46851)
                     /locus_tag="VHC05_000314"
     CDS             complement(46624..46851)
                     /locus_tag="VHC05_000314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000269808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401659.1"
                     /translation="MWTDGRIDYQGQKVDYIAKVSPQPSEVGIDLGCIFKLDIEVAEE
                     TIVSYDRGWELYPETEEREAILEAVLMVLTV"
     gene            complement(47037..47540)
                     /locus_tag="VHC05_000315"
     CDS             complement(47037..47540)
                     /locus_tag="VHC05_000315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401660.1"
                     /translation="MDKVEYIAKNYRDMKMKLHLVQEKLLNYRPISENSVIQSLVFEK
                     SEHEKVKKSKNHGRSELISLSFREKQEQENQEYLSSLLNTYYCLKMDLYYFEFVMELI
                     PEDLKPLSKDLIYLGKSWTELEEIYEISHSTLAYRRRKILKQLRKCYRWTSKSLELKV
                     EDYHIPI"
     gene            complement(47533..48909)
                     /locus_tag="VHC05_000316"
     CDS             complement(47533..48909)
                     /locus_tag="VHC05_000316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006268649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEQ5401661.1"
                     /translation="MKLTLHNYQVVAKDFIIGHPYAAVILDMGMGKTATTLSAVNELM
                     FDRFEVTKVLVIAPLRVANTVWSDEIEQWSELRNLRYSKIVGTPKQRKVALQKDADIY
                     IVNRENLPWLVEQCSPYFKWDMVVIDELSSFKSWQSKRFKAFMTMRPYMKRVVGLTGT
                     PSSNGLMDLFAEFKVIDGGERLGRFIGEFRSRYFEEGRRNGNIVYEYIPMDYAECQIQ
                     DKISDITISMKALDYLDMPELISTKKLVRMSEKEKEKYIQFKKEYVLSELDGLEVTAA
                     NAASLMNKLVQLSNGAVYSDDHTVVPLHEQKLDALEDILESANGEPVLVAYWFKHDLA
                     RITGRLEKLKVTSRVLKTEEDIREWNKGNVPVGLIHPAGAGHGLNLQKGGHHLVWFGL
                     TWSLELYQQTNARLWRQGQEAETVVIQHIVTEGTIDEEILKALGNKDAQQERLIEAVK
                     AQVGGTDG"
     gene            complement(48890..49171)
                     /locus_tag="VHC05_000317"
     CDS             complement(48890..49171)
                     /locus_tag="VHC05_000317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001208489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VRR-NUC domain-containing protein"
                     /protein_id="HEQ5401662.1"
                     /translation="MREKYVEQALVKSVKARGGICPKWVSPSFSGVPDRLVFLPKGKF
                     GLVEVKAPDQKPRKLQVSRHKLFERLGFKVYVIDRIEMIGEVLDEIDIT"
     gene            complement(49456..51741)
                     /locus_tag="VHC05_000318"
     CDS             complement(49456..51741)
                     /locus_tag="VHC05_000318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HEQ5401663.1"
                     /translation="MKFTLSHSGQTGIQTTTVYPNMVTITDKAILQNVAQFDHVAGLF
                     VQNTRSNANFIKSDVLVMDIDNDHTENPDEWLTEEFLKDVFADYNFALVTSRSHMQTK
                     AGKAPRPKFHIYFQINEVTDKDIYVAMKEELCNQYKFFDDHAKDAARFFFGNPNAQVI
                     WHDSWLTIDEDLFQVVSIEDEEDFDADFYTPPSGPIQQGSRNSTMSVFAAKILKRLGV
                     TQEARDGFDEQAQKCVPPLDKAELDTIWGSAVRFYNRTIKTSKSYVAPDAFNRETLKP
                     DDYSDVGEAGVLAREYANKLAYTNATDYLYYDGTHWRENKQLALGAVVHFTDEQLAEA
                     IALLESADKQLQSSGIDELTIKAGGKRLENAVETPLQLKYLKAYLAAKEFHKFVMKHR
                     DYKNLMAVYNTAKPILSVELSELDSDDLLLNTPEATYDLRKGINGQQEHNPEDYITKI
                     TAVSPSDQGMGLWQETLATFFCNDQELIDYVQEIIGMAAIGKVYQEHMIIAYGGGANG
                     KSTFWNTIARVLGSYSGKLSADALTMSNKRNVSPELAELKGKRLVIASEMAEGMRLNT
                     AVVKQITSTDEIQAEKKYKDPFHFVPSHTLVLYTNHLPKVGANDDGTWRRLVVIPFNA
                     KITGRSDIKNFADHLYDNAAPAIMSWIIEGAEKAIKANFKTNVPTAVSSSVKAYREAN
                     DWLGHFLGDCCQVGDQLSEKSGELYSQYRAYCAKNMEYTRSTTDFYSALEQAGFKRKR
                     TSKGNHILGLKLVEDGYDFLD"
     gene            52128..52451
                     /locus_tag="VHC05_000319"
     CDS             52128..52451
                     /locus_tag="VHC05_000319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000077671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401664.1"
                     /translation="MSKMKELNRLIHDMEETAKYYLRLVDEFKKLLTTEDETAPKSNP
                     PKNEPQKEIQLEDVRAVLATKAKDGYKEDVRALLNAYGASSLSVLDPKHFAAVLEEAG
                     GIGND"
     gene            52444..53565
                     /locus_tag="VHC05_000320"
     CDS             52444..53565
                     /locus_tag="VHC05_000320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2800 domain-containing protein"
                     /protein_id="HEQ5401665.1"
                     /translation="MTNHAILSASASHRWLNCPPSARLTEDLPDTTSDFAIEGSDAHE
                     LCAYLVEKALGRNARDPTEDLTFYNDEMQECAEEYRNYVMEQVEKARGYSRDPTVLIE
                     QRLDFSKWVPEGFGTGDCIIVADGRLQVIDYKHGLGVQVDADHNPQMMCYALGALEMF
                     DGLYNFDNVTMTIFQPRKHNISTFKIEKTELLEWAENVLTPKAELAFKGEGEMQSGKH
                     CQFCKLKNVCRKRAEDNLALAKMEFADPASLDNEDIAEILPKLDLLISWANDIKAYAL
                     NQATDGHPIPGYKLVEGRSVRKFSDESAVSQAVIEAGYDPYEKKLLTITAMTKLLGKK
                     TFNDLLGGLIIKPSGKPTLVPIDDSRQEMNLAKNEFKEE"
     gene            53570..54118
                     /locus_tag="VHC05_000321"
     CDS             53570..54118
                     /locus_tag="VHC05_000321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2815 family protein"
                     /protein_id="HEQ5401666.1"
                     /translation="MTTKVITGPNTRFSYLNANEPKSINGSTPKYSASLIIPKEDTAT
                     INKIKAAIEQAYKEGESKLKGNGKSVPALSTLKTPLRDGDLERPDDEAYKNAYFVNAN
                     SPHKPGVVDGNRQEIIDTSELYSGIYGRASITFYAFNSNGNKGIACGLNNLQKLRDGE
                     PLGGRTRAEDDFATEDDDDFLN"
     gene            54137..54304
                     /locus_tag="VHC05_000322"
     CDS             54137..54304
                     /locus_tag="VHC05_000322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401667.1"
                     /translation="MMYTILTCTIMGLWVLIGLYFGYMTIRDDIRNEVERKAKQNKEK
                     LSQTPLSRKNK"
     gene            54353..56308
                     /locus_tag="VHC05_000323"
     CDS             54353..56308
                     /locus_tag="VHC05_000323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017769760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase"
                     /protein_id="HEQ5401668.1"
                     /translation="MPIKELSIDIETYCEIDLRKSGVYRYAEDDSFELLLIAVSVDNG
                     PVTVYDFNKEKLPQDILEALVEDRVIKWAFNASFERICLSNWLKKHHPEFLSDGFLSP
                     VSWRCSMIWSAYLGLPLSLEGVGTVLKLKDQKMREGADLIRYFCLPCKPTKVNGGRIR
                     NFPHHAPNKWSTFIDYNRRDVEVELAIKERVKNFPVPSFVWNEYHQDQIINDRGIGID
                     VDFVKAALKIDGESKAKIQAELKTLTGLEKPNSVLQMISWLREHGVATDSLDKKAVKE
                     LLKTVDETTAQVLKLRQQAAKSSVSKYQAMMNCVCKDGRARGMFQFFGANRTGRWAGR
                     LVQLQNLPQNHLPDLKEARELFRTGDLESTELLYDTQDTLSQLIRTAFVPSKGKKFIV
                     CDFSAIEARVLSHLAGERWRSKVFEQGKDIYCMSASQMFGVPVEKHGQNSELRQKGKI
                     AELACGYGGSVGALKAMGALDMGLSEEELQPLVNSWRQANPNIVLYWWDVDNAVKTAV
                     KELLPTSTQNIQFEVKSGILFITLPSGRKLAYIKPRIGENQFGGESVTYEGTGTAKRW
                     ERLESYGPKFVENIVQAISRDILAFSMKQLNDFKIVGHVHDEVIIECPIEQKLDEVAS
                     LMGIAPDWLSDINLRADGYECFFYQKD"
     gene            complement(56347..56916)
                     /locus_tag="VHC05_000324"
     CDS             complement(56347..56916)
                     /locus_tag="VHC05_000324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401669.1"
                     /translation="MTINVNFFNYCQTQSSSTGVQPTESEVLAPMFVQDYYMDSRHSG
                     LLRGTFRQCRIMGIPILTAFVPVAEEDYEQMVWWYNNSVNDYLKDYRKPSKNAPKISS
                     WEAFTEKQDLPMIDDDIELYLFMDQFEFLKAKLAESNFQAPDILEMLFDGYENKEIFE
                     KLGVQKSAGYKKVKNTQKEGLELYNKFNK"
BASE COUNT        16541 a        12530 c        10352 g        17735 t
ORIGIN      
        1 aacattaaaa agagagcttg tcaatgatgc tcatttcgca actattgagc aagctcagct
       61 tgagattttt aaatatagtg agacttacta taaccctaaa cgtctgcatt cagctttagg
      121 atatctctca cctgtagaat ttgaaaaaat agttactcat tagcttaact ttatgtctat
      181 tttttcttga caagtccaac caaatgttag attttttgtc caacttttgg ggtgcagttc
      241 agtcattcga agctttttat tatatgactc ctaagcctat tgacattaac aaaatgactt
      301 caatcaagtt attaaaaata tgtaacaaga tagcgtcttt taagtttcct cgtctttgat
      361 aggcaacaaa gagaaaaatg cccatacagc tgtacatgat aaattcaaca ctattggtgg
      421 catgtggtaa agcaaaaaca agagaggtca ctaaacctgc caccttaagt gattttcctt
      481 tgaagagatc aatcatagga aatcctctaa agactagttc ttccataata ggagcgataa
      541 aagctatcac aagtacaaat agggcagtat aaagcgggaa accacctttg ataagtctag
      601 ctaaggtatg tattgcagca tcattagcac tcacttgttg accagaccat agctggttaa
      661 caagggtacc tacaatagct atcacacgga tgattaacca aaataatgct aaataacccc
      721 agtcaaccaa tctcattttt tgctgtttaa taggggtgtc ttgcttagct tgataaagac
      781 gccataatac aataaggaca cttccaacaa taaccaagta gaaaatacca attccccaat
      841 taagcaccat aggaatatcg tgttgctttt gcaataaaat catcggaagg acattgaaaa
      901 ccatagccag aataatgaac actgctattt ttaaataatt aatgaatcct ttcataaaca
      961 gtctcctttt aggctaacgg taaaattgtc tggtcattgt tgcactccta acgagtaaat
     1021 agagctgaat taacaccaaa actaagatgg ctgttaactc cacttgacca gtaaatagat
     1081 agacaaaaaa taaaatcaca tacaaggaag ggatgatgac tccatttaat gacaacacac
     1141 tttcaaacga tgtcttatga taggcttgta actctgcctc atctagagcc atgatattat
     1201 gttttaattc tttcaaattt ggaaaataag gaacatcggt tccccgaatg gcattgtaac
     1261 gtttcatggc taaagcttga aaaggaatga ccattaataa taaaaggata tccagaagcg
     1321 gaatggccag catggcatgc tgtgaatcat tggttaaggt cagaccaagt agcacattgc
     1381 acatggataa aatagaagct acggcaatca ataacatggt ataagcatgc tttttattca
     1441 gctgacggta accattttca gaaatatcat cctcttcaat tgtgttataa acagccgtct
     1501 cttttttcag ttgcgttaaa aaaacaaaag aaagtgtgag gcctgtgaca actactagac
     1561 gatttaataa gataatcagg ttaatcacat catcttttag gaacgtgagc tgatctaatc
     1621 tctctccatg gtaacctaaa aaggctccaa ccatgccacc tataatccct cccgccaaac
     1681 ttgatagcaa taacattttt aacaagcgta aaaaactatt cttcttcttt ttcattcctc
     1741 gacctccact agacgaaaca cctcttcaac tggttcctga aatacctttg caattttcat
     1801 ggcaattata actgatgggg tgtactcgtt acgctcaatg agactgatgg tctgcctcga
     1861 tactcctgcc agtttagcca tttccgtttg attaattcca tctctggctc gtaattcttt
     1921 gagccgattt ttaagaataa cctccattgc catctccttc attctccttt aacttataat
     1981 ttactttcta aaataagaaa aagtattcaa cagcaaggct agtcctgtaa agcccaaaac
     2041 cagatagctc aagggtactc caaaccagat taccctgata agatgataac ttaaaatgaa
     2101 aagagtcagg atacttgccc ataagcaaat ctgcctctta agtttgatac catgtgtcat
     2161 tttctctaac acctcctcat gtctatttgt tactatcatt gtaacatatc tttttctttt
     2221 tgacaacgat aatagtcaaa aaggttatga tgatagtcat ttcaaatata aaaaaccaag
     2281 ttctaaataa cttggttttt atggatttac actgtttcag caactgctgc tagcagctct
     2341 gcaattttac ttgcatcgct accacctgcc atagccatgt ctggtttacc tccaccacga
     2401 cctgctacaa ttggtgccaa ttctttaatc atgttaccag cgtggacatc tttagtttta
     2461 cttgcaacaa ggacattaac cttctcaccg atagctgcta cgagaacaag cacatcagag
     2521 tagtcttttt gtttccagtt atcagcaaat gtacgaagtg cccctgcatc tgcaacatca
     2581 acttgactag caatgaagcg cacgccctta gcttcttgaa catctttaaa gacatcacca
     2641 gctgctgcag ctgctgcttt ttctttaagc tctgcatttt ctttttgaag atcacgaagt
     2701 gagtcgctaa gagcttgtac tttagctgct gcatctttca attgcggagc ttttacagta
     2761 gcagcgatct cttttagggc atcctcttgg ttacgataag cttcaaaagc ttgtctacca
     2821 gtaactgcaa taatacgacg agtacctgaa ccaatacctt cttctttgac aatcttgaag
     2881 agaccgattt ctgaagaatt atttaagtga gttccaccac aaagttcaac agaataatta
     2941 ccaatttgaa ccacacgaac cactttacca tatttctcac caaaaagcgc cattgctccc
     3001 atctcttttg cggtttcaac gtcagtttca gtcgttgtga ttgtaagagc gttccaaatt
     3061 tgctcattaa cttcttgttc aatgtgacga agttcctcat tgcttactgc ttcaaagtga
     3121 gtaaaatcaa agcgcaagaa ttcttcttcg ttcaatgaac cagcctgagt tgcgtgttca
     3181 ccgataacat tgtgaagggc tgcatggagc aagtgagttg ctgtgtggtt tttctcaaca
     3241 gccaaacgac gctctttgtt gatttcaagt gtgtagtttg ttccaactga aagtgatgcc
     3301 aaaacgttta cagtgtgtag aggttgacca tttggtgctt tttgaacatc aacaacctca
     3361 gcaactgtgt cacccttatc atttttgatt ctacctgtgt cagcaacctg tccacccatt
     3421 tcagcataga atggtgtttg agcaaagaca agaagagctt gaccttctga aacagcttcg
     3481 gtacgttcat tatcagcgat gatgactgaa agacttgatt caagactata tgtgtcgtat
     3541 tcgaatcgtg attcttcaac aataccagct agggtttcat tttgcatccc cattgaacca
     3601 cccttaacaa cagctgcacg cgcacggtct tgttgttctt tcatggctga cttaaagcct
     3661 tcgtgatcaa tcttgtagcc tgcatcttct gccaattcct ctgtcaattc aaccgggaat
     3721 ccataagtat cataaagttt gaagatatct ttaccttcaa gagtatcctt accttcagcc
     3781 ttaagctgcg caagcaatga atctaagtga ccgctacctg catcgatagt acgagcaaat
     3841 gtttcttcct cacgtttaac gattttctcg ataaaatcac gtttttcaag cacttctggg
     3901 tagtagcttt ccatgatttg tccaacagtt agaaccaatt tgtaaaggaa agtttcgttg
     3961 atgccaagac gacgaccgtg cataacagca cgacggagaa gacgacgaag aacgtaacca
     4021 cgaccttcat ttccaggaag cgcaccatca ccgatagcaa atgaaagcgc acggatgtgg
     4081 tcagcgataa ccttgaaact catgttgtcg ccatctggat tataagtttt acctgacaac
     4141 ttctctactt cacggatgat tggcatgaag aggtcagttt caaagtttgt ttttgcccct
     4201 tgcataacag ctgcaagacg ttcaagacca gcacctgtat caatgttttt gtttggtaat
     4261 tctttgtatt ctgaacgtgg tacggctggg tcagcattga attgtgagag aacgatgttc
     4321 cagatttcga tgtaacgatc gttttcgata tcttcagcca agaggcgaag tccgatattt
     4381 tctggatcga aatcttcacc acgatcgaag aaaatctccg tatctggacc tgaaggacca
     4441 gcaccgattt cccagaagtt atcctcgatc ggcaccaagt gacttggttc aacgccacaa
     4501 gcaatccaac ggttatatga atccttgtca tctgggtaat aagtcatgta gagcttatct
     4561 ttagggaaat caaaccagtc tggacttgtc aagagttcaa atccccactc aatagcttca
     4621 tcacggaaat agtctccaat tgagaagtta ccaagcattt caaacatagt atggtgacgt
     4681 gctgttttac caacattttc aatatcatta gtacgaattg atttttgtgc attggtaata
     4741 cgtggatttt ctggaatcac tgaaccatca aagtattttt tcaaggttgc aacacctgag
     4801 ttgatccaaa gaagcgttgg gtcattcaca ggaaccaagt tagctgaagg ctcaacgcaa
     4861 tgtcctttag atttccagaa atccaaccac atttggcgga tttgtgcaga cgataattct
     4921 ttcataaaaa tttagataca aagagtaaga aaaacagtgt tatgctgaag ctagtaatgt
     4981 aatcacacca gttgacacag ctcgtctttc ttgctaggag atcagctata agcctggcag
     5041 cctagtctac tctattcctt tcgttgattt caaatagtcc tcaatacaaa acaagtccat
     5101 ctcacagagg gcgaaaaccg cggtaccacc tctattcaat gaacttgtca ttcttaattt
     5161 acgatatcaa ttgttgtaaa gttaagtagc atgtttatct aattatcaat gactcgcagc
     5221 aaccgtcact tttctgtatc taatccttga taaacaattc ttaactaaat tattataagt
     5281 ttttttaact gattagtcaa taaaatccta cttattgtgc agctggctct tgcgtctgag
     5341 cctcagtctc ggttggttct tcagctgatg atgtctgtgt ttgctctgat tctgatgggt
     5401 tctcttctgc agcttttgat gattcgctgg ttgttgaact ttcacttgca gctttagttt
     5461 tttgaccaag atttgcatat tgcgccaaaa tattagcaaa agctttgtct ttaattttta
     5521 cattagcttt atccaatgca tttgcaataa ccttgttttg gaaattcata tcttttgatt
     5581 tttcagctat aatgatagct ttcaaacgtt tcttatattc ttgccaatct gatttttttt
     5641 ctgctttttt agtcacctta acaatgtaaa acttcttttg ataagaagtt ggatctaaaa
     5701 ccgagataac gtctgatatg ccaccctcat tcaaacttga agccgctttt acgacatcag
     5761 tcggtacatt tgtcgcgcct gaatcaaatt tataggtcac ttttttctca ggtgttgttg
     5821 ttttttcttt agcaatagct gtaaagtctg cgccttcggc ttttagttcc tctaagactg
     5881 atttagctgt ctcttcatta tctaaagtaa tcatttcgac tgccattgtt ggagtataag
     5941 attcatatgc tttcttatat tcttgtgttg tcaattcttt tttagctgct tctttaaccg
     6001 catattctac taattttgaa gagcggatct gacgcttaaa agtctcaggt gtcaagcttg
     6061 attgtgccaa agcagcagag aatgaagcgc catactgttc agctgtttta tgatacgcct
     6121 tttcaacttc tttttttgaa accttatcac catattgagc ttcaaaaaca cgactaatta
     6181 ccagatttag catcgctttt tgcgatactt ctgtgttttt tgtttcattg taaaaatcac
     6241 taacgctaat tgtatcacct ttcatcgaaa taaccttagt attgtcatta gttgattgac
     6301 aagctgctaa agccatcact gaggccaatg tcacaacact agcaatgagt ttatttgagt
     6361 ttttcattta cttctgagct cctttttatc tttaactaat ttattataac ataaatttat
     6421 caatgttact taatctggta atacaatatc tgcttgattt ttacgaatca ttaataatcc
     6481 atcactaaga gggaccaggc tagttgttag gtttggatga attaaggtgg catcaaacaa
     6541 agactgtaag ccacgataaa tagtacgctg acctcgtcga atgtcttcga tcggttttgt
     6601 aatgtcacct ccttgaaaga catcatccaa aatgactaca ccaccgactc ttaacagtct
     6661 taaaatctct ggtagaaaga caatatattt ggatttggcg gaatccataa acacaaagtc
     6721 aaaatttcct tcaagtgtag ataatatatc tgctgcatct ccttctaaca ggcggatctg
     6781 ttggcgactg tcgtacttag caaaatttgc tttagcaaaa tcgatcatct ctcgattacg
     6841 atcaatagtc acaatcgtcg catctggtgc attttcagcc attaaaagcg cagaaaaacc
     6901 aatggctgtg ccaatctcca aaatgtgttt tggctgtaag ctttgcaata aaaacctgaa
     6961 ataagccacg acctcaggct gaataatagg aatgttttct tgtcttgcga attgctctaa
     7021 ctctgctaaa aaacctgtgg tttgcttctg ccgtgttcgc atataatgaa caagctcttc
     7081 tttgacaaca ggacgacgca tattatgatt tgctgtttta ctgtatgatt taaccataaa
     7141 cctaattata taaaaaaacc ctaggctttg ctagggttta cttttaaatt ttttatagga
     7201 catcatttct ttaaccttaa tgctaccatt aatcctaaaa tgtataagac aataaaaaca
     7261 cataaggtga gaagataatt atgagtccat tcaacagtga tagataataa cataggtcca
     7321 gttaatgcag ctattgccca agctgtcaat atatacccat gtaatgtagc cagttccttt
     7381 gccccaaaaa gatcacttaa ataaggcgga atgagagaaa aacccgcacc ataacaagtc
     7441 ataagggtgg caatgcttat catgaaaatt agggaactat gtgcaaatat taaactaata
     7501 gtcataatta tgcttactaa aaataaaagt attactgtca cacggcgtcc aatatagtct
     7561 gacaaactag cccacactaa acgaccgaaa ccgttaaaaa tccccatagc accaaccaca
     7621 attgctgaca tttctggact cataccagtt agatcttgtg ccattggcgc aacaactgag
     7681 ataagtccta agccacatgt gatattgata aataaaatta cccaaagaca ataaaatgat
     7741 tttgttttaa gtgcttcttt agcggtcatt ccttcgatta aataactgtt attttgtaat
     7801 ctttttttat ctagtatagc tatctcagca gcagttggtt ttattatcaa ttgagaagca
     7861 aaaagcataa ctattagata aatcaaccct aaaaggtaaa atgttgctac caaaccttct
     7921 gtttcaatta gccactgggc aatcggactt gttaataaag acgcaaaacc aaaccccata
     7981 atagcaaacc ctgttgccat gcctctttta tctggaaacc attttataat agttgatatc
     8041 ggtgtgatat atcccgctcc aagtcctaag ccaccaataa caccataacc aatatataaa
     8101 agccaaattt ctttacgatc aatcgctaaa ccagtcagca tatttccaga agcataaaga
     8161 atagctgaca ccgttccggt tagacgagga ccatattgtt caactaaatt tcccataaaa
     8221 gcagcagata aacctaaaca aaaaatagct aaagaaaagg caaaagcgac aggagcttgg
     8281 tcccaaccgg tctcttgtaa aattggatta cgataaacac tccaagcata ggtcgatccc
     8341 aacattaagt ggagaagtat ccctgctgtt gcaatgatat aacgttttgt tttttccatg
     8401 aaaaactcct tttttattat acgaacgttt atttttaaaa aaacataaat gttagtattt
     8461 taattctatt atctctttta taaaatgtca aatataataa aaatatgttt tatgcgaacg
     8521 ttatctctaa aacaatagaa tagcgttaat ctgaagcgcc ttactcaact attggtttta
     8581 tttaagtgag tgaccacaca ataaaaaaga aaaaaatgaa accgtcaaac taaggtcaat
     8641 gaagcctgct tttcaggact gataatccac taaaatataa aaagaaaatg accgatagaa
     8701 atggagattc acaccaactg tgaatctcca tttctatcaa tcctaaactc tttttgtcct
     8761 tgacttttgt gattttagct tttgtgtatg cctttggaca cgagtacttc aagttctgtt
     8821 agacgttcgt caaagacttt aaaggcggct tccaaataat caccttttgc catatcaacg
     8881 cctgctttag caatcacttc aagtgggtaa tcagaatttc ctgacttaag gtaggccaag
     8941 taatgatcga tatcatcttg tgtgccatgc acaatcttat ccgctaaata gcttgcagct
     9001 gcaaaccctg ttgcatattg gtaaacataa taattgtaat agaaatgagg aatacgtgcc
     9061 cattcatact gaataaaatg attatctttt ttacttaaac cataatattt ttcatttaaa
     9121 tcagcgtata gctggttaag gtattcactt gttaacactt ctcctttttg atcagcttga
     9181 tgaatggcat gttcaaactc agcaaattgg gtttgacgga aaactgttcc acggaaacca
     9241 tcgaggtaat ggtttaaaat ggcaaagcgt tctttctcat cttgaacctc atttaagaga
     9301 gcttctgtca taatattttc attcgttgtg gatgcaattt ctgccaagaa gatactataa
     9361 tccccataca cataaggctg tgtttcacga gtgaaagtag aatgcaaact gtggcctgtt
     9421 tcgtggacaa gtgtgtaaag attatcaagt gtatcttgcc agttcaacag catgaaggca
     9481 ttggtatcat aggaaccacc tgaataagcc ccagagcgct tccctttatt gacgtgaaca
     9541 tcaatccaac gttcggtaaa agcacgatgt acacgatctg cgtaatcctt accaaaaaca
     9601 gccaaaacct tctcagcctt ttccaaagcc tcatcataac caatggctaa atctgtttca
     9661 gataatggcg tgtaaacatc atacatcttc aaatcgtcta aaccaagaac ctcttgacgc
     9721 aatttcaaat aacggtgtaa gagtggtaaa tgtttgttaa ccgtttctaa taaagtgtcg
     9781 taaacagctt ctggaataaa gttagcagcc atggcagctt gacgtgctga atcgtattta
     9841 tgaacacgcg ccttatagtt ttgcactttc acattggttt gcaaggtttt agcgtaagta
     9901 tgttggaact gttcataagt actatacatg gcttcataag cagcttggcg aacgctacgg
     9961 tccttagatt ccattaggct aatgaagtta ccatgggtta attcaacgtt ttcaccttta
    10021 tcatttctga ctatcgggaa aacaatgtca gcgttatcaa gaatactaaa ggtttcttcc
    10081 gcaccattga aaatttcttg agctcctgct aataattcct cttctgcttg actaagaaca
    10141 tgttcgcggg cttggaataa tttgtcaaag aaatggttgt acactttcaa ctcaggggtt
    10201 tcagtaagga aagcctgata gtcttcttga tgaagcatca tcacttctgg atcatagaat
    10261 gaaaagactt cgctaaactt tgcatacaag cctgaagcct tagcttggta ttcttgatac
    10321 ttggcaacag tagtgtcttg gtcatttttc atgtgagcat aaacatagac tttctccaca
    10381 cgacgagcca attctaaata tgtttttgta acctttaaca aattagcact agaatccagc
    10441 aaatgaccag caaaaccttt agatgcctca acttcagtag ctaagtcact gacttcagct
    10501 tcccaatcct tatctgttgc aaaaatagtg ctcaaatccc aagtgtattt ttcttctaaa
    10561 tggctgcgat tatcagtcat aacatctcct tctcattttc tattactatc cattttaaca
    10621 taatattttg gtgaaaaaag cgtttgcacc ttcttatcct tttctttttt gtaatagact
    10681 ttaaaacttt cataataagg gcgaagattt cctttaattt gacaaaaacc gctggaagat
    10741 tgaactggtc tccattgagg ataaaaagca tcagttgtta acataagtaa attatagcct
    10801 gataagtaag ccttttcttg tcgtcgtagc catttcgggt gtctagctaa aagagctctt
    10861 tgtattcttt tagataggtt cacagtcatt tttttctgat aagaataaag gatttcttgc
    10921 tgatagggta atcgaaacat ttccataata ttgtggtcta aagaaatggt tttggttagg
    10981 taacttacct taccaaataa gtcttcatgg attaaatatt tgagacgtag cagatttgca
    11041 gctgcatcca gctcccacaa atgaaagccc aaactagatg aaaagtaaag aaactgtttt
    11101 tgcaaagcag ttaaatgagt gttaagccac aattttcttc ccagtaacca tcgtaccgga
    11161 tacccctttt cttgataggc tttggtgcgt ttctttagac gctcaactgg caagggactg
    11221 cactgaattt ctaaggctaa cttatcattc acccaaaggt ctgctatctg ttgcagctca
    11281 ggaagatatt tttcaataca aacagcttct gttcggacta aactggtgta aagttttgcc
    11341 ttcaacgtca aatgttcctc agattcattt tctgcttgga attgacaatg agctagttgt
    11401 acatgggcaa aatgaggtcg tctaattgtc ccctgacgca agcgaacagg agatttgcaa
    11461 gctgggcaac gaaaaggcgg tttcgttgaa ataggctgag ttactagcga aatgagctga
    11521 ttcttaccat ctaaagcggt taatattttt gtcacctcct attagatctt ccaccttatt
    11581 attcgaaaac taagtaccaa actttaagta gctttagttt ttttagccat caaaaaacac
    11641 tcccatttcc aatttatgag agtttaacac aagggttttt ataacgcttc aggttaagga
    11701 gacagtggga attgaatctt tttgcttacc tgattttgta acaacaagat gactaaacat
    11761 agcaaaagtc ggactcatca tgactataat agtcaatgga cactttattg attaagcaag
    11821 aatagcttct ttttgaaagc atgttttgct cagtctagat acgttttaat gagttgcctt
    11881 tctgactccg ttagataacg atattctccg ctggctaaat gaccgagttc cagtcctgca
    11941 aagtgcgtcc gtttcagaga ggtcactttc aaaccatagg tcaaaaacat ttttttcact
    12001 tggtgaaatt ttccttctga aatggtcaaa ctagcctgtg actggtctgt atcggcttta
    12061 agaatagtca attgagctgg ttggcattgt tcacctgttg ggaaacaaat accagctgca
    12121 aaaaaatctg aggcatcttc tgctaacaag ccattaacgg ttacaagata cgttttagaa
    12181 acatgatgaa tagggtgcaa catccgaaac cctaggggac cattatcagt gagtaaaacc
    12241 aacccttcgg tatctctatc caatctgcca acaggataca agtctggact tttatcttct
    12301 tcagcaagct gatcaataac ggttaaatag ttagtatctt tcttagctga gaccacccct
    12361 gatggcttgt tgaggataat gtaggaatgt ttaggatgcg tcactcgctg tccagtcacc
    12421 tcaatcagtt gcaagccagg atcaacattt tgtcgaccat ttctggcagg catgtgatca
    12481 acccaaaccc cttgagcctt aatcagtttc ttcacttgac ttctagagcc aacttttgta
    12541 ccttctaata atttatctaa acgcatatta gtagtgtaac ataaatttac ccttgcaaaa
    12601 gaaatagaag ttacaagact tcttcttaaa tgaggttgac tatctcctca tttttgttct
    12661 tacaaggttt aacgactggt taggttagtc taattgtgac gcagcagctt catccacaat
    12721 gacgataaca tgatcatgtt tttggagaat acttgctggg aggtcttctg tgattggtcc
    12781 aaaaaccatt cccttgatcg catcagcttt ttcttgtcca aaggcaagaa gaacaatcat
    12841 tttggacttc atgatggagg caattcccat agagatagct tgttttggca catcctcaat
    12901 acttgtaaag aaacgactat tggcttcaat ggttgatttt tgaagatcca ccacatgcgt
    12961 ttcttcttca aaagaggtcc caggttcgtt aaaaccaatg tgcccattac gcccaatccc
    13021 aagcacttga aaatcaatcg gatgctctgc aatgatttgg ttatatcgtt tagcttcagc
    13081 ttcgatatca gttgctaaac cattgggcaa gtaattcttt ttaaaaggct tcgcattaaa
    13141 aaggttttga cgcataaaat aatcataact ctgatcgctc tctactgaaa gaccgacata
    13201 ttcatccaag ttaatacttg ttaagtccga aaaatccaaa ggacttttga ccatttcttg
    13261 gtaaaaacta attggtgaac ttcctgttgc taatcctaac gtcttagctc ccttagctaa
    13321 gctatctttc aataaagtaa aagcgatttt cccaccttca atctgatctt ggacccgaat
    13381 aattttcatg tcattctcct tttctaattg gtatagacct ttcgtgtttt tattatatgg
    13441 tatataccaa tttttgtcaa gcctatcctt tactttctga tgaaagatta aagatgacgg
    13501 gttagacgac aagtgatata atagaaaaga tttatcttac atgaaagagt tactaggaag
    13561 agatttacta gtggctttaa aggagcccca atgaatacta acgattttga ttttgagtta
    13621 ccagaagaat tgattgccca aaccccactc gaaaaaagag acagttcaaa actattgatt
    13681 attgatcacc gtcaaaaaac tatggttgat agccattttg accatatcat tgatcaatta
    13741 aatccagggg atgccctcgt catgaataac acccgtgtct tgcctgccag actttatgga
    13801 gaaaaacccg atactcatgg tcatgtggaa ttgcttttgc ttaaaaatac acaaggagat
    13861 caatgggaag ttttagccaa gccagccaaa cggctcaagg ttggtagcca agtcaatttt
    13921 ggagatgggc gtctcaaagc caccattatc gacgaattag aacatggtgg acgaattgtt
    13981 gaattcagct atgatgggat tttcttagaa gttttagaga gcctcggcga aatgccattg
    14041 cctccttata ttcacgaaaa attaaaggat gctgagcgat accaaaccgt ttatgctaaa
    14101 gaaaatggct ctgcggccgc cccaactgct ggtctccact tcacaacaga cttgctcaaa
    14161 aaaatcgaag ccaaaggggt acatttggtt tatttgaccc tacatgtagg gcttgggact
    14221 tttagacctg tttccgtgga taacctcgat gagcatgata tgcattcgga attttattcc
    14281 ctctcagaag aagcagcgca aaccctaaga gacgtcaaac aagctggcgg tcgtgttgta
    14341 gctgtaggaa ccacctctat tcgtacattg gaaaccatcg ggagtaagtt ccaaggggac
    14401 attcaagctg attcaggttg gaccaatatt tttattaaac caggctacca attcaaggta
    14461 gttgatgctt tttcaactaa tttccatctt ccaaaatcaa cccttgtgat gctagtatca
    14521 gcctttgcag ggcgtgactt tgtccttgaa gcttacagac acgcggttga cgaaaaatat
    14581 cgtttcttta gctttggcga tgccatgttt gtcaactaaa aatctatgaa attacttgga
    14641 aaatggctat tcttcttgat gtttctgact ttttgcgtca gtttttggca gaaagactat
    14701 cagcggattg cctttgaaaa agaacacaaa ctttatcaag atttagtggc acctttttac
    14761 caaaactatc ctaaattacg agaactccag ctttcagaag ctattaaatt acgccacgac
    14821 ttgcttgatt atgttcgaaa gctcgataag gacggatggt cctataaagc catccaaaaa
    14881 ggataccttg aacaactcgc tgttagagga aactcttatc atttcgaaca actttatagt
    14941 cgcattcgcc tgataggatc acctgacttt caaaagctct ggcaacaaga agagatggca
    15001 cagacgcctc aagaagctca aaaacggcta cagctgctct tgacgtattt aaagatgcca
    15061 gacgagttga caggacaatc aaaacaaaca cagcaagtat tggcacaatt aagtccaaag
    15121 ctatcgccaa cagatccttt ttgggaccaa ttatctgccc tgattcaggc ttgttatgtt
    15181 aatctcgaac acattcctta tagccgtttt aatcggaaaa ttcatcaact ccgttacctc
    15241 atatcaaccc agcaaatgga gtgggttcgc tcacattatg ggaataaagg gaaaaccgat
    15301 gcggatgcct tagccaaata tttggctact ctagaagatg acgattatgc tctttatgaa
    15361 tcttctagat accataataa ggttgctagt attttagatg ctaatggcaa tcatcaggca
    15421 gtctatacag acaatattcc tcaagccaac tataagattt tgattcattt tcactcagag
    15481 tttattttgt cagaatctgg acaattttta gtagcactag atcctgataa cctaacgcga
    15541 aatagtattg tcaatggttc ttctttcaat tatggcaacc aaaacgatga cttgcaccgt
    15601 ctgcttgata ttgaccctat tctgcttttt gatccggctt ttattgaaaa agcaactaat
    15661 agtcctgatg caacttttct agttcccgat ttagaacagc aaagggataa gcacaatccc
    15721 atttacagca gaaatggcaa atcatctaag cagctaacac gcgctgccgt taaaaaattc
    15781 aaaaaattgc ttcaccatta tcaagaaaca agaggtgaca ataagacctc aaaaacacag
    15841 cattaatctc aaaaagcttg acctgaagaa acaggccaag cttttttaat gagcaaaaac
    15901 ttattttagt gactttcatc agtaagtatg tctactatca gactaatgtc aactgagtat
    15961 tagatcatgt tgtgattgac tctatgccac tcattaatta catatggtag ctgaacaagc
    16021 tgcacataac caaggccatt gacttcctct gatgcttgtg ttgctccacc caaaccagat
    16081 gaataaagag caatcaaata aggagactct tcgcaaacaa tggcacctac atttaaggct
    16141 tctctgacat aacccggttt ttgataaacc tttacatgag gcaaataagt cttgtaatac
    16201 aaatcaggga aagattcacc aatgtagtac aagatatcct tatatttatc ctgatgctgc
    16261 cacaagtaat ccaaaacttg caaatagtaa gcggtggtga ttttattgcc attacgatca
    16321 atggtcgtaa tagccccgga taccttcccg tagcggtcaa ataattggta agccttattc
    16381 atgccaccca atcgttctgc tagagcataa gctggcgtgt tttctgagta caccaaggaa
    16441 tattcttgca tatccggaat agacatggca ccattgaatt gagcaacata ggcatgatgt
    16501 tcctgatcat attcataatc agtttctgta atgtcaaaac gctctgtcat ggataatttg
    16561 ccttatctac caccagcatg tttaatggca gcttataggt gcttcctgca atcattggct
    16621 gatggtcatt catggcaaca gtcctacctg aattgaggtc tttgtaggaa aaggcaattt
    16681 gggattcacc aatgccaaat tcctttaaat acgccttgac cgtattgacc aaactcaaat
    16741 ggttgtcatc gtaatagagc cctaaggcat ccatttgcac taaatctgta tccataacag
    16801 cttgcttagc ctctttagat ttttcaggta acggttttta aacagttttt ctaatcttgc
    16861 ttttcagccg tttgctgccg cttacctgct ttaggaggaa agcctttctt tttaccagtc
    16921 aaacagccga caagtaaggt ccctatcatc attcctaaaa taatccctac aatggtagtt
    16981 ttcttctctc ttaacaccta aaatctccta tccgttctat tctagctaaa tttagctaaa
    17041 aatcaaggaa ttacattaaa aagacaaact atttttatct tttctaaaaa atgatatccc
    17101 cacactgtta ttcacaaaag cacttaaaaa accaatctct ttttgagatt ggaaaccctt
    17161 ttcttattta gcggcttggt aaagttctga tacttttttc caattaatga tttcaaagaa
    17221 agctttgata taatttggac gtacattacg ataattcaag tagtaagcat gctcccacac
    17281 atcaagtgct agaattggtt ttttgccttc tgaaattgga gtatcttggt tagcggttga
    17341 tgtgatttcg agttgtcctt ctttattaac aactaaccat gcccaacctg aaccaaaacg
    17401 tccagtagca gctgctgtaa attgttcttt aaaggcgtca aatgacccaa aagcatcatc
    17461 aatggcttgt gcaacatcag gagtgacgtc ttgtttttca ggtgataata gttcccagaa
    17521 aagcgcatgg tttaggtgtc cgccaccatt attaattaag gcttgacgaa tatcttctgg
    17581 aatcttagtg acatctgcca atagttcctc cagattttct ccgatctctg ggtgtttttc
    17641 taaagccgca ttggtattag cgacataagt ggcatggtgt ttatcatgat gaagagtcat
    17701 tgtctccgca tcaaactgtg gttcaagagc atcatacgcg tatggaagtt ctggtaaaat
    17761 aatagccatt ttcctgtcct cttttccttt atgatacgtc tatcttatcg caaaaaataa
    17821 gagctttcaa ctaatttgat tatctcttgg aaagcggtcc aatgcctatt tttgagagtg
    17881 agtcatgatt tttaagagag caatatcaac tagataactc ttctcataaa gtcctgtttt
    17941 tatctggtaa tctgtctcaa tcaaggtttt caccgctcct gttagaaagg caagagataa
    18001 ggtcctagaa tcctttaacg catacttgac ctggtaagga ttaacccgcc gcccaagaat
    18061 atctgataaa ctaatcacta gttgttgctc gttttttacg tctctagcaa gaatagtcag
    18121 ctgcaaaaat aaacgaaatt ggcctagcat gatagcgatt aatttaatgt catcttctcc
    18181 agataaccgt aaatcatgaa tcaaatctct agccgcatca attttacctc ctaggacaag
    18241 tctagtcaga tcgaaaatat tatcttgtaa acttttagga atggcttgct caatatcagt
    18301 taggctaata tttcccgttt ttttataggc ttttaaaaag gccatgtttt tcatgatttg
    18361 actaaaatca tcgtttgatt tcaaaagtaa ttggtcaaag gcaccactct cgaaacctaa
    18421 acccagttga tgactgtatt tttgaaaata agttcttagc tctgcttctt tcagagggtt
    18481 ggcttctaaa acaagggcat cacgtttcaa aagcttaaca agccgtctct tactatccaa
    18541 tttacctgga gcaaagataa ttagtcgagt agtctctaag ggattttcta aataggcttc
    18601 aaaggtcttt aagtcttttt cttttaagaa acttttttta ttggtcgtga tatctaacaa
    18661 atggtcaaaa atgaccacct tctgctcagc aaagaagggt aggctcacta gatccatttc
    18721 tgcatcctga taagcggcct cagacatatc aaagtaagaa taggccaaat catccttatc
    18781 aaaagcaatc tgctccatta agcgggattt caactggcta tactgaccaa tgtcatctcc
    18841 tgtgacaagg gttataagac ccaaattttc tttactcagt ttttcaatct tttctatcgc
    18901 aatcatgctt ttattatatc atctttctcc taaaaggaaa gcgactgcct gtttcttcgt
    18961 caggctggaa ttttaactaa cggaccgttt caagatgcca gcttgtccaa ccagtcaaac
    19021 gaatagctcc ttgcgtatcc gttcggtaat aagtaatttg tctgtcttcc aaacgggcta
    19081 aggtttctct gtgaggatgc tgataacggt tattttttcc agcagaaata aaggccactt
    19141 taggctgaat atggtctaaa aaagctgcac tagaagaggt atttgatcca tggtgacctg
    19201 cttttaaata atctactctt agttgaggat aacgttttat gatctcgttt tccccctctt
    19261 tttccaagtc acctgtgaaa agaaaagttc gatttaagag cctgccataa agtaccaaag
    19321 aatcgttatt tttcccgtcc cctaactgcc aaggatagag tacctgtaag acacttccca
    19381 taataggcaa ctggtctcca gctgctaaaa ccctaacgtg acattttaaa cgccttagcc
    19441 gcctaacaaa gcttggatgg cttaaactgc cttgactagt caaaatctcc tttatccgaa
    19501 tagctttggc aaccacttcg atatccccca tatgatcagt atcggtgtga gttctcaatt
    19561 tgatacaagc tcaataaaaa aatgaaactc ctaattgagt ttcatttgag tttcattttt
    19621 ttcttaactt attaatccgt acccactaac tcacaattta tataatcatc aatcgaaatc
    19681 acttttaact tggctccttt ttggataatg acttcataat aatgtgtctc ttcattatta
    19741 agatttccta cataaaatgc gttagttcct ttaggaattt taatacgtag ttttttataa
    19801 ggatctctga attcaaatcc tttgacaaga gaggtatgaa ggaagccttt ctctttaaaa
    19861 tcaatacatc cttccacttg tgctgattct accatttttt ctaatgtttc catactaact
    19921 cctcgatata ctacaatatc tgcttttgtg ctatattttt ttagagtttg gtaaatattt
    19981 tctatctttt catcaacaga acctgacctc aatctaccat ttatggttgg cccagaagaa
    20041 gcaataatat attcgtcaga tggtattttc cccacatacc ttggtggctc attatttaga
    20101 tactttgcga caaagagggg tacatcagct tgggaactcg aaagcaaatc ccatttctgg
    20161 ccagttctaa gtatttttcc tttaagttta tagcaaaact cgttcataag actttattct
    20221 tacctacttt ttttacacac attatatcaa aatttcatag aattactcta ctacctctat
    20281 tccattctta aattttatag ccactgtttg gtcacaaaaa attttaattt catctaccat
    20341 agtttcccaa agcaactcat caaactcact tataagctca ctttgctgat tgagtgtctt
    20401 taaaaattct ttgaggtctt tttgatgact ggctgcttcc agtagctgct tctctatcga
    20461 ctcaatttca ctaaccagtg catcatgccg ctcgaccaag ttactgtact ttttctgata
    20521 ggtatcttgg tcctgtggca ttatcgcatt ctctttcact agattagaaa ccatttgagt
    20581 gactacttct acctcggttt caagctcaac caaccttcgt tcaaggtcag aactttcccc
    20641 aacgtcaagt aacatttcta gattctggat aatctcatcc ttattgctga ttaccttatt
    20701 tattgctgtt acaaaccaat ccttaatttc atcttcagta acatgaggag tggtacactt
    20761 cttttcgccc ttgtacttct cattacattg gtagataacc cttcgatatt ttgatgtgga
    20821 gtgccagacc ttgctaccga agtaatgccc acaatcccca cataccagct ttgaactaaa
    20881 tagtgtagta ctccccttac ccttttcttt cctatctagt gatgcttgaa ctgcatcaaa
    20941 cgtttcttta tctacaatgg cttcatggtt attttctaca taatactgtg gtaactctcc
    21001 cttgttaatg ttcttctttt tggatagaaa atcaattgtg taggttttct gaaggagggc
    21061 atcacccttg tacttctcat tccttaacat ccgtttgatg gtcacagaac tccaatgatt
    21121 cttaccacta ggtgagagga taccttgttg tgtcaagtct tttgcaatgc tatagggagt
    21181 tttaccaagc aatgcctgtt ggaaaatgta gcggacagtc ttagcttctt cctgattaac
    21241 aacaatctca ccattctcgc ccttttcaaa gcccatgacg ttggtatagg gaaaatgtac
    21301 ctttccttcc gcaaactgtt tcctcaagcc ccaagtgacg ttctctgaga tgctacggct
    21361 ttcttcttgg gccaagctag acatgatggt aatcaacagc tcaccctttg aatctagagt
    21421 ccagatattc tctttctcaa agtagatttc aactccgact tccttcaact tacgaactgt
    21481 tgtcaatgaa tcaactgtat ttcttgcaaa ccgactaact gacttggtaa taatgaggtc
    21541 aattttgcca gccaaggcat cctcaatcat gctcttaaaa cccactcgca gtttagtatt
    21601 agtgccacta ataccttcat ccgagtacat tttaacaaac tcccaatcgc ttcgagttga
    21661 aatgtattct gcataatacc tcatctgaga ttcatagctg gttgtttggt cttcatgatc
    21721 agttgatacc ctcgcataac ctgctacacg acgtttctta ggtagcgaaa tgctagctaa
    21781 ctctgagttc ctaggcgcat ttgcttcaat agttatgacg tttttcataa gaagtgctcc
    21841 tttctaacct tcagttcata ttttctacct tttataggaa agacggtaat taaacctact
    21901 gatgagtcat aaataacctt cttgatattt tcggtaaccc aatttttatc tggtttaaat
    21961 ccaattttat cttcaaatgt agctaatatc cgtttttcag atagagtctt actaggacaa
    22021 gaggatgttc cgaacctgtc tctagtgcgg caacagtatc tgatggttcg gtgtaccttt
    22081 ttggagtcta ctctagtaat cattattttt ccacaatggc tacactcgat taactctcta
    22141 aaagtacctt tgtgcatatg gctttcctga tacattacct tgtaccgacg ttctttttct
    22201 tgtagtacca catcaaaata agactttgaa acaatggctt catgagcatc ctctacaata
    22261 tacttattct tttgcccatt atttcgttta ggatttcgtg aaaaaggttc tcggtaagtc
    22321 ttctgtaata ccaaacgtcc aaagtatgct tcctgcttaa agaactctcg gacactagag
    22381 actgtgaagg gatttcccag tcgtgtcaag actccttgct catttaactt tttagtaatc
    22441 attggggcat tatctccgtc caagaaccat tgaaacacct gtcgtacaac ctttgcttca
    22501 tcaggctcaa tgacataatt ctcaccattc caacggtagc catagatatc ttgaggtgta
    22561 tgaggttgac cctgttcaaa ctttttctta atctgccatc ttaagttttc actgatgtta
    22621 tgcgattctt cttgagcgac agaagctagg agagttaaca tcaactcgcc ttcggaactt
    22681 aggctatcta tcccttcttt ttcaaaggta attcctatgt tcttttgtct aagtacacgc
    22741 actgtagaca ataggtcaac ggtgtttcta ccgaaccttg caatggattt agttaaaatt
    22801 ctatcaattt ttccatcatc acatgccttt aacaaatctt gtaacccttg acggttactt
    22861 tgttctttac cgctgatgcc ttcatcataa taaacgccaa ccaattccca gtctggatga
    22921 gactgaatta atctactata atagctgact tgagtggata acgaatgatg taggcgacta
    22981 tcagataccc tcgcatatgc tgctacacgc aacttaggtt tttgcggtgt catcatcggt
    23041 tgaattcgtc taactattct caatttgata cactcctttc gctactatat atcactctaa
    23101 aggcctcatt tatcaagtct ttaggtcgat aatctactaa taaatggttg atatttttca
    23161 agcatctttt ccttaaattg ctgatgaact tcctcactaa taatcctaga ttttaggagt
    23221 ctatcggcct gtatcatggt cagttggtaa gtcatctcat cttgtaattt gtcattagtc
    23281 ataatagccc tcctacctta ctaagtaagg ctgagggcat tttttccgct ttttaggcaa
    23341 aaaaaataag cctgacagaa aatacactcc atcaggctta acataagtta ctgtttaatt
    23401 gccttttcca aggcctgtac tgaagcaacc aatttctcat cgtcaaactt ttgtgactct
    23461 aagaaacggt tgaaatcgcc atcgtctaag gttaagtgtg ctgcaccagc tgattgcaac
    23521 tgaacaactg tatcaatgtg accaatccca aagacagcac cattgaccac tgccacataa
    23581 ccttgtttcc cactttttga tcgtacgaca aaatttttca tatcctcatc ctccgaagtt
    23641 tctactttct ttgtgctagt tgctacctca taaggcagtc taaaccagcc aaccatataa
    23701 ccaaccaatc caccactatg gctatcaact aatcgcccat cagaatacca ctttcgtgac
    23761 acacgtcgag tgtaaccgcc aacttccagt tgatcgttga ccccattacg gttactatcc
    23821 gaataaccat cgacattttg ttccacacct tcaagtccag taccatcaga atccgctaaa
    23881 caaacaccga tgtgaccaaa actgtgactc ggtacacgaa tcacgtaaaa gtcacccgcc
    23941 tgtgggttaa cccctacggc atcataggtg acctgaaaac cattggcttt tgccttatca
    24001 agacagtcaa tggcattggt gtaagacata ttcttccctg tttcctcctg aacgatttta
    24061 tcaattagag ccacacattg cccaccataa ggattggtag gcaccgtcac tttggtattg
    24121 actttcgaga gggcattggc aacaaccttt tctttacttg tcattctcat cctccttatc
    24181 ttcgtttaac tgacgtaaga cttgtttaat acgattaggc actggcaatc caatacgagt
    24241 cgcattctcc aagatggaca gtccttcatt actgaagtag aaaaagataa cagctgttcg
    24301 aactgcccca ccttgtttta agacatgtag gtcaatcatg tgggcaacag ccaccaaaca
    24361 gataatcatg gcttttttga aaatcccttt tttaccgata gaactggaga ggttcttctc
    24421 gacaatggct gccataatcc ctgtcacata gtcaatcaac ataaaaatca aaaggccata
    24481 aagaaagcca tcgatttctc caaaaataga accgatgacc ccaccgattc ctgaaaacac
    24541 taatttatta gtcaaaactt cttgtttcat tgtttctcct ctaagcggta cgtcgccacc
    24601 gataaactgt aatataaggt tgtaaattgt tatgagcctg tcctcctcca gaattacctg
    24661 tgttatttcc ttgaggatac aatgatgaac tcccgtcaga agaataatct cgacgtgtgg
    24721 cctgattacc tgaattggca gaaacatatt gcggatgtga gtgaacaggc atttcattga
    24781 tggttaaggt atgagttttg ctgccacctg tttttgaaac agtattaaat tcgctttctg
    24841 tctcagagac accaaccaaa acacgtccat tcccaaaccg ctcccacttc cctcccataa
    24901 aagttgaagg actttcagaa ctcgtagact cataaatcgt tccaatcgga tagaaaatat
    24961 caatcagctt tttgttacgc atgatgatgt ctccatcaaa ataagaaggc tgactaccat
    25021 ccacatcaag aacccctcgt gtccatgctt ttcctatccc catccctgtc ggagataagc
    25081 cataaactac cttttcagga ccaaccgtaa actcaaaatc cgtttcatag aataaatctc
    25141 gcaaatgacc aatgatggta taagacttgg tttggtcata ggtgccattc agggtagctt
    25201 gaaaattctc tttggtatgt tccgttgtcg tactccagtt agcggctcca cctacattcg
    25261 ttgtctttgt accagttgat aaatcaagaa tatcccacgt catagtggct cgattcttct
    25321 gactattgcc tacaatgagt ggtgcaattt ttacttttcg aatcacattt aattgattca
    25381 tggtagttcc gactcgaact gaagtaaagg atagaatggg tttaaaatat tcaagtagag
    25441 aaatctcgac ttcctttctc ggactttgtc ttcctcttga atccgtcaca aaagcagaga
    25501 ttttggcacg accaacatgg ttaatacctc ctactccgcc attttgtgca gtagctacat
    25561 tctggagttg tatccagcta tttccttcaa atttaaacac ttccgctcga taaccactag
    25621 ctggaatagt tgatccataa attcctgtag caccattaaa ggtaaccttg ggatttgact
    25681 ccaatgaaac aaaggtattg cctgtaatgg cattttgagc aatcgtattt aaatccgata
    25741 aactgataga ggatagactg ggaaccaccg agctcggaag ttgaagagtc acttgaatcc
    25801 gagactcacc gatgaccttt cctccataaa tggtttgtac taaaattgtg ccaataccag
    25861 aggtcgcatt ggggatttga ggagctaatt ttgcaacttc tggtgtccaa ctacaagaag
    25921 tggttgcacc agttgcgacc actccactca aactaccaaa ttgccaagta accttgtgtg
    25981 taaaatcccc acttgctctc gtaatagaaa tggtaattgg agaacccatc atattcccag
    26041 aaacactagc tgttgaggac cgtggaatat ctcgtaatcg taacgattga taaccggtat
    26101 taagagttcc tggtgaccat ccaccacttc ctgaaaaggt cgcagaaaaa ccaatggtct
    26161 tttgaccatt ggaattgtga gcgatggtga tggttttatc aatgagatga agagaagagt
    26221 tcatgctgta catatctggt ctaccactcc aagaaagagt ttgaccatct atggaaacac
    26281 tggcactaca gttatacatc ccaaaggttg tttggccatt tcgtagccac aattgaacac
    26341 gtacagttga ggtattattg gcggtgctag ttcctgtttc ttctacccta agtagaagat
    26401 tgtaccctcg gtcattatta ctgccataat ctgccatagt ctttcctttc taagtcttgc
    26461 tgtcgatgaa gcgacaaacc aaatgtttgg ggttatgcct tgcagcttct aaacgataat
    26521 atccaacttg tagcgtttca acgaatacac catggtggat tttaatcaca ccagaagtaa
    26581 cggtcatgac cgcattccct gctgatttaa tcatcattcc ttgtggggtt aattcgataa
    26641 actcagaatt atctttctta ccaatgatga caccattatc acctgctcgc agataagtgt
    26701 tcacaaattg taaaagcaag gcattacttt tcaaatcagc ttcaatagct gcgatgcgtt
    26761 gcgtgtttgt gacaaaatcc tgattgaatt tggtgagtgt ttccttgtta ctcttttcaa
    26821 attccttata ggtcttgagc caatcagaaa cttcactggc cagtgccctc gcttccatat
    26881 ccactcgaat cgactccgtc ttctccgtta ggatatccaa ttgttgcttc ataaaacttt
    26941 ggtctgcttt cccatcaatt tgcttcatca aatctgctaa ggatggacct ggagcggttg
    27001 ccacattgcc atcctctaat tgaacattcc gtaaccaaac cacatctcct tgcgcccatg
    27061 ctcctgagga taaggtaaag acaaaagacc atgttgaatt actggacacc ttccagctag
    27121 acaccactcg ttcccaatta gctgtcagtg aaacaggctt tgttccacct aattcagagc
    27181 caatcatcat ggatactgct cttgaagctt ttagttccac cgaaaaagtc atggtctgtc
    27241 caatgcgtgt ccgcaagtca aaaaaatctc gcttaaagcc accacttcct gctttggtac
    27301 aagtcatttt aatcgagatg ccactgacag atgtactatc ttctacgatt tcttttcgcc
    27361 attctgactg aagattagtg aaacttgttt ctcgcatggc atagtcatca atgtaattcc
    27421 gaccacctaa aacagtcccc tcaaagaaag aagaccaagt ataatcactt gggttcgttg
    27481 agggtgttgc ggttggtcga ttcaccgcca gaccaaaata gcgttttccc ttgggtgagg
    27541 gtgaaatgcc ttctcctttt tcactgtccg catacatctt ccacgtatat aaggtttgac
    27601 cggtatctcc cttattccca tatacaccaa taaccactgg tgtcgtcgac gtttcatttc
    27661 catcagtgaa aacagttcgt ttgtaattcc aaagatattt aatggtatcc gttaaaacag
    27721 gaatggtttt tgaccaacca ctcgttgatg tgaggactcc tgttttttga ttactcgcta
    27781 aatagtattc ttcgatttgg gaaatgctga cacctttgtc tccttttgga cctggagtga
    27841 gtgacagttt agaaagttga ctcttggtag ctagttcttc gcctctcact tttaagagtg
    27901 gtgtatcaat tgaaatattc ccattggagt ccaatgaaaa tactggcttg tgacttccag
    27961 gaataacaac cttgttggca ttgacttcta tcgcatttaa atactcagtc aacacctgat
    28021 gagaaaccaa acgacgcatc caagcagaat tggacacggt tagttcatct atctttgctt
    28081 tttgaatagc cgcaaagcga atttctgccg cctctgagga taaatagtca actgctgctt
    28141 gattgccact ccgaattgct tcagcttttg ctcgctcaat cccatcttct acatccttgt
    28201 ttactcgact catattgaaa tcaagtacac gactgagatt ggctcgctcc ctttcaatct
    28261 gacgttgaat ctttccatca ttgagagtta agagctcatt tgcgacagat gatattggat
    28321 ttcctgacac cccttgtcca ccaaacgcga ccgtatcgtc aaatgagatg gatgtgattt
    28381 gctctgttaa ggcattaaag cgataaccaa ctgctctttt gaccacatca acttgatgaa
    28441 gtctactttt tagggtcacc tcgtccccca actgcacctc ttgcccatct agttcaaagg
    28501 cttcaatctc aatcacttct gaaacctgat ctaaatggtc attgctaaat tttgccatcg
    28561 cccattgtct caattcttcc tcggtatgga gattattgtt ctcatactcc gcctcatgca
    28621 cataaggata ttgatggatg agaggactct ccaccataac cgaaagagtt ttctcttcct
    28681 tttcaccttc tggcttaaaa attgaggacg cataaatgcg agtgacaata gactgactag
    28741 aacgagtacg atcaaacttt tctaagttat gatgcgttga aatgaccacc ccacgattct
    28801 ttcctcgatg ttctttgata gtgaacaaaa agttatcacg aaccaactct ccctcccaag
    28861 ttcctaaaat agaatgtttc ccatccatca acacttggta aagtgtagct gtctctgtcg
    28921 tattaaacga ccgtttcttt gtaatatcac tatcaaaaga aaagggtgct atatctcttt
    28981 tagcttttga aatcaattgt ccaagggcac tttggcaggt cacattttga ttcgaaactg
    29041 gtagaataga gcgacgcatg atatcatccg taatatgttg gcaagtcaca cgaaccctat
    29101 cgttttcttc aactggtttc ttaatccgaa agagttgttt tttgacatat ggtactggac
    29161 atagtatcaa tttatctgtc accaactctt tatagatgcc tgaatctgtg atgggatagt
    29221 caaattgaag cgtaaaatct ccattcaaag tttcttcaac ttccgcactc aaggtttcat
    29281 gaagaggaaa cccattccat tttggagttt tagtttgtcc gtctaacaaa aataacatta
    29341 cgtccacccc cataatattt caatgtgaag actggtgatt ccagtaccaa gaacaacacc
    29401 aactttcttg tccttttgat tggcatcaag cgtgataaaa tctcctgacc aatgaaccaa
    29461 ctctccactt tccgtcaaaa aactaggatg acttgggtca ttatccataa ccaaagtttt
    29521 gtttagttgc tccaaaccaa taacttgttc accgatggtg aaacttgtct ctccagtcga
    29581 tttacctgaa acagtaatct taggataaga cagagctgaa ccaagcaagg gaatcatccc
    29641 attcttcgtt aaagtatact cactcacttt cttaaaatat cgagtggggt gacacagaaa
    29701 agttacctcc atgctgaaga ctcctaaatt atcttgaaca atatcaaaac tatccacctt
    29761 atagcaccag taccgagtca ttttcatgcg ctcactttca agccaaaagc cttcacgagt
    29821 taaaagtgca gaaaattcat taatttgttc ctcagtcgca ccaataaggt gaatccgata
    29881 agctttctca atcgcttttc ggtgcttatt ggtcaaaacc aaaccaccac tcaaaccgtc
    29941 atgttcttgc agttggcttt tagaagtcgg aatatgaaaa cttggtctat cttccacgag
    30001 tatcttgtaa gggaatgagg ccgttgatac accgtctatg attaaagcat tatgttggat
    30061 cacaaagtca cccctctcaa tgattgttga cgagttaact cgtcatgaat tctttctgct
    30121 acttgattgg ctagtcgttt gatatcggct tcttctctta tcactacatc tgtaatggaa
    30181 acattgatga aattgccacc agttcccatg gttgaggcga ttccttcacc gattgccgca
    30241 agattctgtt tggttaaagg caagacagcc tctttcccag cttcaccacc aaccatcagt
    30301 tgtttctcat tcatgccaaa ggctgtcggt ttcgttagaa tcccaccctt ggcataccaa
    30361 gcaatcgaaa tcttaggcaa accgcccttt aaccaatcaa gtggattggc agaaccactc
    30421 acagaaaagt gaggtaaagg aatatgtggc catgaaatct taaagttaaa cagattcttg
    30481 atggcattaa tggcagaaga tacaacattt tttgcaccat tgatggcgtt tgagatagaa
    30541 ttcttgatac cattccagac acttgaaaca gtggagctaa taccactgag aatactagaa
    30601 atggtctgtt gaatgccaga ccagccactg gatacaaaag aaacaattga agaaatcact
    30661 gacgaaatga cggattttat cgtgttccaa atagaagaca cgatacctga aatggcagat
    30721 aggatattgc tgatggtatt tttgataccg ttccaagtgt tggaaataaa ctgaccaatt
    30781 gctgacaaga tagtcgtcac aatttgttga atagcttgcc aaactctttg aagaacaccc
    30841 ttaatggttt cccatgcacc agaccaatca ccagtaatag cctgcataat ggctttgatg
    30901 attcctaata caactgtgat agctgtttct acaaccgttt tgataatctc ccatgccgtg
    30961 gtgatgatta actgaatatt tgcccaagca gcttcaagat aagggccaat caaagacatg
    31021 accgtctgaa taactgtaga aatggcattc cagaccgttt ccactgctgc ttgtataagg
    31081 gcttgatttt ctgtccacca agtggtaaga gttccccaaa tcgtcatgat aaaggtagaa
    31141 atctcttgaa tgatcacaga aataaaagca tagatggcat tccagatttc aatgactgca
    31201 gttctaaagc cctcattgtt ttgccacagt tcttgaatcc aaacgactaa tagggtaatc
    31261 actgctatga tgcctagaac tgttccaaca atcggagctg ctgcaacgac caatccgcca
    31321 atggtcgttc ccatggcgac tgctgccgct tgaagggcta agagtccagg taacaacaga
    31381 ccgacaactg taattaaccc ccccataatg acaataaagg tctgaatggg accaggtaag
    31441 ttgctgaacc aattggcgac agcttgtagt aattgagcca ataattctaa gactggtgct
    31501 agagcttcag ctaaaacacc accaacctct gccatggcag ctttagcagt attttgtgca
    31561 atcgtaaatt tatcaatcgg atcaagtgtt gcttcataag ttgacgtcac aactcctaaa
    31621 gcattcttag cagtccctga taaatcatta aatgaaaaag caccacgctt aatggcatcg
    31681 accattcgtg gcgcagcttt tgaaccaaaa acttctgaag cgagtgtcag actctctgtc
    31741 tcatttgttg aattcttaat ttgttcaaca gtttttgcca gaccatcttg taaggttaag
    31801 ccatccttgg cataattaac agccgcttta gataaagtag aaagtgcagc acttgaatcg
    31861 acaccagctt tttcaaagcg tcccattaag gcgacaccct cgtcaaagga taacccaagt
    31921 gacttaattt gaggagcacc agatacgacc ttactcatta gatcctgaac accaacccca
    31981 gtttgttggg aagtaaaagt gaccgtatca agtaccatgg cgaggtcttt agactcaaga
    32041 ccataggctt caatggcctg tttggcagaa atagccgatt gcgtcacatc cgaaccattg
    32101 atttcagaat acttaatcag taatgctgaa gcctgtgata aagcatctcc tgttaagcca
    32161 aactgagtat ttaattcccc aaccgcacta cctgctgtcg caaagtctgt aggaatggaa
    32221 gtggcgagtt cagtcgcaat atcttgcatc ccttcaagtg cctttccact agcaccagtc
    32281 ttggtgatga tgatatccat tccttcatca acttcacgaa aagcttcaag agattgttgc
    32341 ccaaattcga ttaacttttg agagagttca cccaatcggt ctccaaactc cataaggata
    32401 tctgctttta ataaaccatt ggtttgttca aggcttgctg cagattgttg ggaggcattg
    32461 gaaagcccct ccatttcctg ttggagattg ttataggctg tcttagtatc gttgagtgtt
    32521 ttctcaagcc gattggcttc gacagaattc tcgccatatt ctgatttggt tagttctaac
    32581 tgacgttcta aattcgcaat ttgacgctca acgagttcag actgactagc aattcttctt
    32641 tgtgctaagg ctaatttttc agactctgaa gcatttgaac caagctgact ctcttgcaaa
    32701 cgaaaggtgg aattgagttt ctcactctct gatgctaatt gggcctgttc agcttctaaa
    32761 ctgtttaatt tcgaccggtt gctttcaact gtgtttccgt gagaatcaag cgctcgatta
    32821 actccttcaa gttttgtttc atagcttttt aggacatttt gtgttgtctc aacttcacgt
    32881 tggaatgctc gatattgttc tgcaccaata tccccacgtt ggaattgcgc ttcaacttga
    32941 ctttgtgcct gacgtaaggt ttctaatttt tctttcgtgg tcgcaatctg ttttgaaagc
    33001 acctcttgct tttgagtaag gagagtgaca ttgccagtat caaatttcag tgctttatca
    33061 atttgtttca gctctttagt ggattccgct gattctttat ttattccctt caaggctcgt
    33121 tgtaaaggtt gggtgtcacc accaatctca atcgtaatgc ctttgatgtt accagccata
    33181 gttctccctc ctttctctaa aagttatcaa aatcagcttg ggttgctcgt ctagtttgtg
    33241 gtttgtcaga acgcaaggcg acataatccg tctgataatc cagtgccatc ccaatagaga
    33301 tgtgttttaa atcatccata gatagtccag tttccttgca acaggacaag tagctttcta
    33361 ccgtgaagat ttcttcactc gcttcatcgg tttcatcgac ttttttcgag tcgacattcc
    33421 ttgatttaac atctccatca agactggacc aatctcctga atcggtaact cctccatctc
    33481 cataaagaaa acatcaaatg ctttcacccg tggattggct gatttggcaa atacccaaaa
    33541 tagtcgatga aagaaggtca tatcgaaatc agaaagaatg gagacatcca tattttgtgc
    33601 ggttagctcc tctccttctt ctaactgatt aagttggtct aaaatagact tggcattaat
    33661 catttgaaag aggtcttgaa agtaatcttt accgaattgt tctttatagg caatcggcgt
    33721 gtaagcatta cttgctagtg ggtaaacttt cccacaaatc gtcacctgtt ttctcatgta
    33781 cgactacctc cacttgcgac agttggctca tatacagact taaaccaatt tttcttcact
    33841 gtttcggggg tctcttctgt tgtccgacga cgaaccacct gatcaagtgg acgtggactg
    33901 gctgtgaatt tcaattccac ttcattgata tcactaccat tcttggtttt tgagcctact
    33961 gttggtcgag aggcataaca gtaatagagg acatgaagtg tctccttctt atccccttca
    34021 aaacggaaca ttaatgcgaa gtttttccga gttgcattgg atgattccgt aatcacctta
    34081 ttggtatcat ctagtgtttc tcctaacact cgagttaaga actcttgtgt taaaagggca
    34141 accttcaaag ttccactata accatcatta gactcagtcg tataaaagtt gatattatcc
    34201 gctttgtagg aacctgaatc tcctgttgct tcaagggtca actctgcagc acctcttaat
    34261 cgttcaacat tcccataggt taaggctccg tcactccctt ccgttgtgac ttctgcccag
    34321 tggacatctt gtagaccaaa cgtgacttta tttttttcag ccatatgttc tccttcttaa
    34381 aatgcaaaat gaaaagcaac ctgataaagt tgctcggtat caatataagt ttcaaccttg
    34441 tcaaaaaaca aatgttgttc cgtcagaaaa gtttcaatct tcccttcaac gtcgaggtct
    34501 ttcttccttg tgtaaagttc aagaatgaat tgcgcgccct tatggtaaac ctgattgtct
    34561 gccccaaagt tttctgattg cggactataa taaaccataa aaggcggact tggactgtga
    34621 ccttcttcga agtgatgata agcaatcgga agatgtaagg cttttagctg tttaaaaaac
    34681 tccttttcac tcataagtta cctcgaatct tcttctccaa agcttgaact gctttttgtt
    34741 caacggggcc aatatgagga cgcccggaaa ctcgaccacc attttgtttg gcatagccat
    34801 tctcaagtag atgagttagg cctggtgtcc gattatgaat cgttttcgtt ttaccagtgg
    34861 acgtgctact cgtttccttt gaagtccacc ctctcacata gcgaccactc cgcttgggcg
    34921 atgtagattt tagagtcgca atcgcctcgt ccgttacatc atcgactgct tcaactaccg
    34981 tctctgttgt ttgatgcaag tattcctcta gctccttttc aatagcccta ctcagttcat
    35041 cagctctcat ggctcttcct ccactcgaca tttgaccatt ttcttttcaa aaaagacatg
    35101 gtcaattgaa agaatattaa acgatttccc ttgaaagatg agttgtgtat tggtggtatc
    35161 aagtgaggcg acttctgaat catatctaag agtgactatc agctgaagtt ttcgtttcgt
    35221 ttgacccact tcaaatatct catcactatt tgcttgattc acactagccc atcgtgaaaa
    35281 taaattagta aactgacttg tttcgttacc aatatcatct tgagtaatca cacgtttctt
    35341 gaaaagaact cgctggttta aaggtgcaat tttcatttaa aacacctctt ttcgcaaacc
    35401 acctaacaga tgatagagcg tctctttcaa atcatgatgg ttagcctctt ctcgatgctc
    35461 gaaaagataa gctaccgcat agagcattgc ggagcgaata agcggtgtat ccaccaactc
    35521 atccactcgc aatacgtctt tgcagagttc ttcactcgtt gcaatcaaga cttttatcaa
    35581 attatcttcc tcagaagtat caactcgtag atagatttta gcttctaaaa gcgtaagcat
    35641 atcttaccct ttcatggtga gcactttgac agcttcagga agaaccaatt tcccatccac
    35701 acgttggcta cccaagaatc caacttgacc actagtcgca tacaactcgt tcagacgttt
    35761 gaaggaacgc ccttgacggt cactaatcca atagtgggag aaatccccaa aagcaagaac
    35821 tttttgccca gaagcaattt ctggggcata gcttgacgta tagtatggtc gattcaaaat
    35881 catatctggt actcctgctt gaacagatgg ttgccagatg taatttccgt tgttgtcctt
    35941 caacttacgc agagccttga tagtagaatc attgagaatc caaacggaat tcttacggta
    36001 aggtgacttg agagaatgat aaaggtccat cacatcatca aaggtgatgt tggcacctgt
    36061 tgaagtaacc ccttcagtaa ctgtggtaaa gacaccagtt ggtttaccag aaccatcacc
    36121 aatcaagaag gcttcttctt ccttagaccc aatgcgtcga gcaaactctt ctgccatata
    36181 ggattcaagg tcaaagacag agtcatgaat caactcctct gaaatcttga tagctgtccc
    36241 aaccttgtaa gcaccaagag tcacttggcc aaaggtttct tcactctctg ggtaagtacc
    36301 attttcatcc atccacgcag ccgtaccatg acctgtcacc actggaatct tgcgctcacc
    36361 atttgaggtc ttgataatgg ttgccaaacg acggaagaag ttctcctctt caagagcctt
    36421 aatcaagcgg ttctcgtatt catcaggtac caagtaacca ccttgaccat cattcccaat
    36481 gttcaaggta ttattaacgt caaagaaatt cttttgacgc acatttttcc agaatgattg
    36541 gttgtaaaca gttgaagccg tacctgtctt ctcatcacca ccagcatcag ttcgtggttg
    36601 agagacaata gccgcgctag ttgcttgtga cagttcacgc tcaatacgtt cttggcgttc
    36661 caaacggtca atctcttttc caaggtcaac cacttcttgt tccaacttat cgtagtgttc
    36721 actatcttcc tgtgaaatca tgcccttttc atcacgacat gaatctaaga agttcttggc
    36781 tttatcccaa accttggcac gtttttctcg tagttctaaa attttgtcca tagtataaat
    36841 gtcctcctag ggttttaata actgtagtcg tttttccaag gtgcttactg caaccttggg
    36901 tttatctatc aactgttcac acttggcgac cacttgattg gttactgtct gcattgaaaa
    36961 tgcataggca tcttgtgact catcattgtc atgagtgcca tcgaagataa tctgatccgc
    37021 aaaacctaac tcaactgctt tctttgcatt gagccaagtc tctccatcca tgaggtttga
    37081 gagtttctga cgacttagag atgtcttaat ctcataagcg ttgataatcg actccttcac
    37141 ttcatttaga agctgaatag ctttttccat ctcacgtttg tcaccactcg caaaagtggc
    37201 cggattatga atcatcatca tagagactgg actcatgttt acaattgttc cagccatggc
    37261 aatgacagat gctgcactag ccgcaatgcc atcaatgttt acggtgactg ctcctttata
    37321 atccattaac atgttataaa tctgagccgc cgcaaagaca tctccacccg ggctattaat
    37381 ccaaagtgtg atatctcctt gttctgaaag cagttcatct ttaaagagtt gaggagttac
    37441 ctcatcccca aaccaagatt cactggcaat cacaccattt aaaaagaggg ttcgttcccc
    37501 ctcatttttg gcccaattcc aaaatttatg catctttgat aaaacctcct gcgtcttcta
    37561 acttggtcat gttgccattg accaagtaaa ggtcaccacc ttcttctttt gaaagtgggt
    37621 tcatgtcctc taagcgtcta atatcatttg ttgacaacca accattttga cggcctatgg
    37681 catagccatt catccgactc tggtagtccc ctcttaacaa accgtccaca ttgaacttga
    37741 taaagtaggt cttcttctca tcaggtaaaa gcagagcttt ttgaaaggct tgttcaaatc
    37801 gaactaccca aggatctagc gtgtacttca caaactccaa ggactgttgt tcaatatttg
    37861 aaaaggaaga tttctccaag tcaccgacca tatgaggtgg tatccgatag agtcttgcaa
    37921 tttcattgat ttgaaactta cgtgtctcta agaactgggc ttcattgggt ggaatcccaa
    37981 tagtcttata gatcatgcct tcttcaagga cagcaacctt atggctattg tttgtgcctt
    38041 gatagacttg attccacgac tctctaacct tactggggtc tttgagaata ccgggatgtt
    38101 ccaaaacacc tccgggattc gcaccgttcg caaagaatga tgcaccatac tcttcagtcg
    38161 ccaaggtcat accaacggca ttttttgcca tagcaatcgg tgagtagcca attaaaccat
    38221 caaagccaag gccaggaaca tgtaaaacct cacttttttt gagaatgata tttcctttat
    38281 ctttgaagtt cgggttgtcc tcttcactac gttgataaac atagtagagt tcacccttat
    38341 catcacgctt gacggtcatc ctatctggca acaagggata caaggctaag acctgccctc
    38401 ttccatcacg aataatctgg gcataagcat tgccccaaat caatagatga ctcatgagtg
    38461 tctcacgaaa gacaaaggat gtcatgtctg gatttggttc atcatgaagt aggtaataga
    38521 gctgatgatt aacatcttgt tccttgcctt catccgtatg cttgtaaaca tgaatgggga
    38581 gactggcaat cgcctcagct aaaattcgca cacaggcata gactgcagtg gtttgaagag
    38641 ctgtcatttc attgacattc ttccctgatg tggttcgtcc aaagaggtac gaaaaatccg
    38701 acccctcata cgagttggtc ggtttgtctc ttgccctctt taagcctatc aattctaaga
    38761 ttcccataga gcctccttct aaaaactcaa aattcctcgc tggtcgtaaa tactaccatc
    38821 atcaccttta tgacggatac aacggtctag tcccataatg agagctacaa tcccatcaat
    38881 cttatcgact gacttctctt tgtctggctt gatgttacca gctggatctt gcctcatgac
    38941 cacattttga gccatccatt tcaaaactgg atgaccagcg tgtgtgaccc tgccctccat
    39001 catgagtttg tataattcct tagatggtgg tgacatatct ttatatccct gaccaaatgg
    39061 cactacagtt aagcccatat cctccaagtt ttgaaccatc tgtgtcgcat tccaacggtc
    39121 gtaagcaatt tctttgatgt taaacttagt agataagtct tcgataaaac gctcaataaa
    39181 gccataatgt accacattcc cttcggttgt tttgagatag ccttgacgtt cccaaacatc
    39241 ataaagaaca tggtcacgtc gacatctcaa aggtagcgtg tcttctggca accaaaagta
    39301 gggcaacaca atgtaagatt catcctcagt ccgtggtgga aacactaaaa caaaggcagt
    39361 aatgtcagac gtacttgata agtcaagccc tgcataacac tctcgaccaa gcagactact
    39421 ttcaactatc ggtctatttc ctttgtcata gacatgttcc gcaatccacg tcaccgtgga
    39481 acttgtccac atattcaaac ggagttgctt aaaaacattt tcttcagctg gattgtcgat
    39541 ggcatttcga taggcttcac gcacacggtc aatctgaatg gtgtgaccca atgatggatt
    39601 tgccttatac caattttctt catcctgcca atcctcatca ttagctaggc cataaacaac
    39661 tgggtagaac gtttcatctt tctttcgtcc agacaagata tctagtgcct tcgtatgaag
    39721 ttcataacag atagagttct tatctgtacc tgcggtagtg atgataaaaa atagtggttg
    39781 ttcacgcgca tcaccagaac ctttggtaag aacatcatag agatggcggt tgggttgagc
    39841 atggatttca tcaaagacaa gacctgacac attaagtccg tgctttgtcc cagtctccgc
    39901 agatagcact tgataaaaac ctgcattatt gtaattaaca atgcgtttgg ttgctcccat
    39961 gattttggat cgcttgttta atgggtttga catccctacc atttgcttgg ccacatcaaa
    40021 tacaatggag gcttggtttc tatcacaagc agcaccgtaa acttcagcac ttgcttcacc
    40081 atccgcatat aacagataga gggcaatggc agccgcaagc tcactcttac catttttctt
    40141 tggaatctct acataagcgg agagaaactg tctgtttcca tcctctttca caattccaaa
    40201 taagtcacga ataatctgtt cctgccatgg taaaagtaaa aagtgcttac ctgcccactt
    40261 ccctttggtg tgtttaagat tttggataaa ggctaccgcc ctatccgctt tcttctcatc
    40321 gtagtgtgag gtaggcaaca taaaaggact tggtttatag tgataagtca tcctatacct
    40381 ccctcaatag actttccatt tcatcttgtt ctccatcact actatcagcc tgtattcgac
    40441 ttcttgcaga aggggttaga ccaaactgct cggagaactt gagcatgatt ttcatgttgg
    40501 tttgagcaat ggaaacttgt ggaacctgct ggaggtagcc gttcggtgtt ttgataatag
    40561 agccatgttt cgttaggaac tcttctgcct ctttccatct agcgtacgct tgacagtatc
    40621 ctgcaaaagc cgtcatatcc atatctgtca aaagacccat ggactcgagc accttgctca
    40681 tgcgtttcca ttctttcttg gcatcctctt ctaaccacga tgggcatcga ggagctttct
    40741 tagttggttt aggttcttta tggttgagag gacgcttacc taagttacct tcaagaactt
    40801 ttaaaccagt tggttttggt ttacgtccac gctgtgccag gtcgctcacc tcctatcttc
    40861 catttttctg acacgcaaaa aggcctcttg cgagaccctt tcggtttatt gtaattgttc
    40921 aaaagcccat tttactgcat gcccaaatct tgaaatgttt cttcagcttc aatgattctg
    40981 tcaaactttc tttcaaagtt atcaaagtct tctaggctat ctatggtttc atagatatga
    41041 agtccaaccc ctttgtatcc attgaaagct acaatcaccc aatctatgta agggatgata
    41101 cttgaggttg ttccatagtt tgaaacattt tttcaagtgt tgtggatgtt gacatttttt
    41161 gttctcctct tcttttgttg tgaacatatt acctctaaag gagtttaata gccagttata
    41221 agctcactat tatcaattat aatctgctat tatttcttta aaaacttccc tatccaaagc
    41281 attcattgca tctaatgaga ccccacgatg gtaagcatac acaagatgac cgtcacgttt
    41341 caaggtcaaa tgagcaatct attcaccatt gatataactt gggtcagttg aagattctct
    41401 gagcaaatcg cagacataat gtctctcacc tctatcaatg actaccaact cccacatagc
    41461 cttattccac ctttactatc ctatcaactc catagacgac actcagccca ctaccattat
    41521 cccaatgaac taaaactgaa gctaagtcgt catgtccata gacagtacct agcgttccaa
    41581 taggtggtgg aaatggatca tccatttcaa gtagtttaac tcgacagcct acagggtata
    41641 aacattcaac tctttctttt gcaccgttat tcattgtgaa gcctccttct ttttggtagc
    41701 tgtatattac cattagtacc aaacactatc cagtaatcat ctaagattta agcaagaaag
    41761 aatagccttt ccaatcgcat aaacaacggt aactgttaca ccattacctg cttgtttgta
    41821 gagttgggca tcagagttta cggcttgagc tttctcaaag aggtcatccg tgaaaccttg
    41881 aagtctaaaa cactcacgag gtgttaatcg tctgatttta accattcgac cattccagac
    41941 caccacaccc atttgaccac tgcaagagag gttatgagca atgcccttac ctactcttgc
    42001 tcgtttcgtt ggagatgctg gataagataa atcaacagag tcaccaagtt ctgccacttg
    42061 atacccttgc tttgtaccgt tccttacttt aattccttct acaactccgt gtctgtcttg
    42121 agaagttaag gtaaacatag gctcaccttt ctcttttaat cgacgaccat tttgacgttt
    42181 gttcactcgg tctggagtta gaataggttg tacttccatc acaccagagt tcatggctgt
    42241 cctcttggta gaacctgctg tgtaacgagc agtgatgcac cgtgcttggt ctgttacctt
    42301 tggtttggtt gtagattggt caatcaagta aagccctgtc tttgccccaa caccgccacc
    42361 agtgccaact aaagttgtag aaataccgtc cgtatcatag acacgatagg actgcatacc
    42421 tcctacaagt tgcttaagat tgccactgct ttctggctgg agaggtaata cttgtcgtct
    42481 acctctgctt ctaagatgtc cgatagtgta gacacgttct cggttttggg gaactccgta
    42541 atctttggaa ttgaacactt gccattcaag gtcgtaccct gcttcgtcca gttcaaggag
    42601 atagtcgagg aaatcgactc ctctgcgact tgataaaagt cccttaacat tctcaaggat
    42661 gagccactcg ggcttatctt cttcactttg gctcttgagg aggtcaacga gtgtaaaaaa
    42721 gagtccactt ctttcagctc gtagtccagc tcgctttcct gcgatagaca cattttggca
    42781 aggacttccc gcagtccata tatctgcttt tggaatgtca tttggcttaa gttttgtaat
    42841 atcatctgaa taccattctc cttccgtatc atacatggct tggtaacttc taaccgcaaa
    42901 tttatccttt tcacaataac caatgcaggt catcccagcc agctcaagtc cacgtctaaa
    42961 accaccaata cctgcgaaga aatcaatgaa ggttaactga ttcatactga cacctcaact
    43021 aaatccgcat acttgatttc tttcccatct cgcataacct tgattgattg gtcaccagtc
    43081 gcttcaaagt aacgtttcac aatcacgtcc acaaacttct catccaattc aataccataa
    43141 caaatccgac ctgtttcttc acaagcgatc aaggttgacc cacttccaag gaatggatca
    43201 aggacgactg ttccacgcat ggatgagttt tgaatgggat aggccatcaa ttgaattggt
    43261 ttcatggttg ggtgctcttt gcttaactta ggacggtcgt attcccaaat ggtagtttgt
    43321 ttgcggtcag aaaaccattg gtgtttccct ttgttcttcc aaccaaagag acaaggctca
    43381 tgttgccact gataagggct gcgaccaaga acaagtgagt tctttttcca gatgcagcat
    43441 ccactcaagt aaaagcctgc atctttgaac gctttacgga agttataccc ttccgtatca
    43501 gcatgaaaaa catagataga ggcatcggac tccatgttct gttcaacatt aacgaacata
    43561 gcaaataaga acttatagaa gtcagagtca ctcatattgt cgttcttaat tttacctgct
    43621 gtctcttcca cattgacgtt ataaggtggg tctgtcaaaa ctaagttagc tttcttatcc
    43681 cccatcaatg tgatgtaagt ttctggcaag gtagagtcgc cacaaatgac ttgatgtttt
    43741 cctaagtacc aaatgtcacc ttgtttagca acagttggtt tcttgagttc ttcatccaca
    43801 tcaaagtcat cctcattgac ttccttgtta tggaccttag aaaaaagctg gtcaatttct
    43861 gggaattcaa aaccagttag gtctgtatca aagtcagctt cttgtaagtc caacatcaaa
    43921 tccgcaagca actcttcatt ccagctacca gtgattttat ttagggcaac gttcagtgcc
    43981 ttaaccttat tctcatcttc aatatggact tgaacgcact gtacttcttt aaagcccaag
    44041 tccttcaaga ccgtcagtcg ttgatgacca ccaatgatag tcatatcata gttgacaata
    44101 ataggttcga cataaccaaa ctcttgaatc gaccgtttga ttttttcgta ttccttgtcg
    44161 ccctttttga gagccttcct tgggttataa ctagctgaat taagttggtc aactgttaat
    44221 gttaaccatg tcatactttc tttcgtcatc atgtcctccg tggtgttctt gcgcaggttc
    44281 tgctacaaaa ttttcttcta gggctaccat aagctgtgaa ggtcttaccg cacagttcac
    44341 aaacatggct atccgctttt tcaggatgtt gcgtcaccca attcttacga cggcaactgt
    44401 ctgagcagaa ttgtttcgtt ctccctttac gaggttgctc aatgggtttc aaacattctt
    44461 tgcacaattg tccatttctt tgtccgtcag aaatcatagc cactactgcc tgaccataac
    44521 cctttagatg agggttagta ctgcagtagc gtttgactgc cgtcagactg aggtcaagca
    44581 agtttgcgat tttgcgatag cccagaccct cgtttctcat tttccacact tgttttgctt
    44641 taaaatcgtt cattttaacc tcttttagtt agcttttatc ccagtttttg ggtaaaaata
    44701 aacgacaaga tttaatgaaa aaccttgtcg tagataatgt ttggggtcag taaaaatcta
    44761 tttttgtgta cccccttttg aattttgcga tttttcacgt ttgagggggc gtcggtctta
    44821 gtctcccaag ggtttagaga tttcatcccc cctcccccaa agggttaaaa attagatact
    44881 tttgtaacga aactccaaga ctaaaatcga tacgtatact ccacatatcg gtcagtcgtc
    44941 ttggtcttcc tatcatgaca agacttacaa agtgcttgcc agttggtttg attccaaaag
    45001 aggtcttggt cacctcggtg gggtgtgata tggtcaacca ctgttgcctt ggtcaatcga
    45061 cctttgactt tgcattgaac acaaagtggt tgaactttta agtaacgaag tcgtgcttta
    45121 ttccattggg cattgtatcc tttggctttg gttgacttgg tatccagttg gtagtttgct
    45181 ttatggttgt cacaatactt gtgaccataa ggtactaggt taggacaacc attttgttta
    45241 caaggtgtgc ttggtcttct tggcatctta cttctcccaa ggaagatagg cttttgtgaa
    45301 atgcccaaag caagatgttt tggtgtagtc tacattcaag agatgaagtt ccttaatgat
    45361 accttgtggg gtcaagtcgt agcgttcacg aatcattcct tccagttgtg ttgaggtgta
    45421 gcgactggtt ccaaaggttt ctacatatac cgacacaggt tctgcaactc caatggcata
    45481 ggctaattgt acttcacatc gtttcgcata cccttctcga acaatatcct tagcaatctt
    45541 tcgtgccatg tatgctgctg agcggtcaac cttgcttggg tcttttccag agaaagcacc
    45601 gccaccatga tgtgcaaaac caccataggt atcggccaca atttttcgac cagtaactcc
    45661 tgcatccgca aacgaaccac caagaacaaa acgtccggtc ggattgacta gaactttgaa
    45721 atctagattc tgacggtaac gaagtgctac tgacatcata gcttcagtca caattcgttt
    45781 cactttggca aggttggcta tttcagtatg ttggatggaa actaaaaagg tatcaatccg
    45841 tttcttctca tagtcgtagg atacctgtgc tttcgcatcc tttccaagta aggggtgacc
    45901 aagcgacatc agtttctcaa ggactcgggt tgctagaaca taaggaagtg gcaggtactc
    45961 aggtgtttcg tctgtcgcat aaccaaacat cattccttga tcaccagcac ctccattatc
    46021 tactccttgt gcaatatctg agctttggag tccaagtagg ttagttaccc gaacattttt
    46081 cataccaagt ggctcgacaa cctgacgaac aatgttctcg agattaaagt aatgtctagt
    46141 tgaaatttca ccagctacca caacttggtt atccttgatt aaagtctcaa ctgccactcg
    46201 acttgatttg tcatacttta gacactccgt caaaatggca tctgaaatct gatcacagat
    46261 tttatctggg tgtccaactg aaacttgttc actagaaata atcataattc ctccacgcaa
    46321 aaagcccaac ctttatgagg ctaggcttta ctttatttta ctgatttttg gcctgcttcg
    46381 taggctctct ccaatgctct tttgataccc cataccgaaa catcgtagaa gtcaagattg
    46441 tcgctccaac gtttttccaa ggtttctaca aaaagttctt cttttgcaat ttctgttaaa
    46501 agggcattga gtttttcttg ttgacgcttt gtcatggtat tgttctcctc ttcttttgtt
    46561 gtgtacatat taactctaaa aaggagatat atccagtcat ttctgcataa atttaaagat
    46621 attttaaaca gttaaaacca tcaaaaccgc ctcaagaatg gcttcacgtt cttctgtttc
    46681 aggatagagt tcccatcctc tgtcgtaaga aacgattgtt tcttcagcta cttcaatatc
    46741 taatttgaaa atacatccaa ggtcaattcc aacttctgaa ggttggggac taaccttggc
    46801 aatgtaatcc actttttgtc cctgataatc aatccgtccg tcagtccaca tggttattct
    46861 cctttggttt ttctaggttt atattaccct atcagccaaa gaatatccag tcatttgagg
    46921 gagattttta tcttttttga catcttaagt atatcacatg tctaggttga aaatcagtac
    46981 taaaccagta caaatttagt gctaatttag taccaattta gtgcactcaa ccatcactag
    47041 atagggatgt gataatcttc caccttaagt tcaagacttt ttgaagtcca acgataacac
    47101 ttgcgtaatt gttttagaat cttacgccta cgataagcaa gtgttgaatg actgatttca
    47161 taaatctctt ctagttcagt ccaactcttg cctaagtaaa ttaaatcctt ggataatggc
    47221 ttcaaatcct caggtattag ctccataacg aactcaaagt agtaaagatc catttttaag
    47281 cagtagtagg tattaagcaa actactgagg tactcttgat tttcttgttc ttgtttttct
    47341 ctaaaactaa gagaaatcag ctcactacga ccatggtttt tacttttctt gaccttttca
    47401 tgctctgact tctcaaatac cagtgactga atcacactat tctctgagat aggtcgatag
    47461 ttgagcaatt tctcctgaac taaatgtaac ttcattttca tgtcacgata gtttttagct
    47521 atatattcca ccttatccat ctgttcctcc tacttgtgct ttaacagctt caatcagccg
    47581 ttcttgttgt gcatctttgt ttcctagtgc cttgaggatt tcctcatcaa tcgttccttc
    47641 agtcacaatg tgttgaataa caactgtctc agcctcctgg ccttgacgcc aaagtcgtgc
    47701 attggtttgt tggtataatt ccaaagacca cgttaatcca aaccagacca agtggtgacc
    47761 acctttttgg aggttcaacc catgacctgc tccagctgga tgaattaagc caactggtac
    47821 attgccctta ttccattcac gaatatcttc ttctgttttc aacacccgac tcgttacctt
    47881 gagtttttct aaacgacccg taatccgagc caagtcatgt ttgaaccaat aggcaactaa
    47941 gacaggttct ccatttgcgg attcgaggat atcttcaagg gcatctagtt tttgttcatg
    48001 aagtggcaca accgtatgat catcagaata tacagctcca ttggataact gaactaactt
    48061 gttcattagg cttgcagcat ttgcggcagt tacttctaat ccgtctaact ctgacaagac
    48121 atactctttc ttaaactgaa tgtatttttc tttttccttt tctgacatac gcaccagttt
    48181 cttagttgaa attaattcgg gcatatccag ataatctagg gctttcatag aaatggtaat
    48241 atcactaatc ttgtcttgaa tttgacactc cgcataatcc atggggatgt attcatagac
    48301 aatgtttcca ttgcgacgac cttcttcaaa gtagcgacta cgaaactcac cgatgaagcg
    48361 accaagacgt tctcctccgt caatgacttt aaactctgcg aacaagtcca tcagtccatt
    48421 cgagcttggt gttcctgtta gtccaaccac tcgcttcatg taaggtcgca tagtcatgaa
    48481 ggctttgaaa cgcttggact gccatgactt gaaagaactc aattcatcaa ttacaaccat
    48541 gtcccacttg aaatacggac tgcattgttc caccagccaa ggtaggtttt cacgatttac
    48601 gatatagata tccgcatctt tctgaagggc tacttttcgt tgcttgggag taccaactat
    48661 tttcgaatac cgtaagttac gcaactcaga ccattgctca atctcgtcac tccagacagt
    48721 atttgcgact cgcagtgggg caataaccaa aaccttagta acctcaaatc ggtcaaacat
    48781 cagctcattt actgcagaca aggttgtagc cgtcttcccc atccccatgt ctaggatgac
    48841 tgctgcataa gggtgaccta tgatgaagtc cttagcgact acctgatagt tatgtaatgt
    48901 caatttcatc taacacttct ccaatcatct caatgcggtc aatgacataa accttaaagc
    48961 ctaaccgctc gaacagttta tgtcttgaca cttgtaactt ccttggcttc tggtcgggag
    49021 cctttacttc caccaagcca aacttgccct tgggtaaaaa caccaaacga tctggaacac
    49081 cagaaaaaga gggcgatacc catttaggac aaatacctcc tcgagctttc acagacttca
    49141 ccaaagcttg ctcaacgtac ttttctctca tcgttctaaa tcctttcgtc aaattgaagt
    49201 gtgtaggtct agtgcagtca tttccaaaac tcctcttata ggcttttttt atagtaattt
    49261 ttgcttatag gatagtttta gaaaagacca taatagacct acacaaaatc aaaaaatgtc
    49321 actcatgctg gtcgttttaa tcatctatct gaaacctcat tcaaaataag ttccaacctt
    49381 tcagtcaacg acttacacac ctaaaataat caaatacctc tattgtggag atctgttgac
    49441 taaaaatgct ggtcattaat ctaagaaatc ataaccatcc tctaccaatt tcaaaccaag
    49501 aatgtggttc cctttacttg tccgttttcg tttaaaccct gcctgctcaa gtgcagaata
    49561 aaaatcggtt gtactgcgtg tatactccat gtttttggcg caataggcac gatactgact
    49621 gtatagttct cctgattttt ctgacaactg gtcgccaact tgacaacagt caccaaggaa
    49681 gtgtcctaac caatcatttg cttcacgata ggctttgacg gaagatgaaa cggcagttgg
    49741 tacatttgtt ttgaagttcg ctttgatggc tttttctgca ccttcgataa tccaagacat
    49801 gatggctggt gctgcattgt catacaaatg gtccgcaaag tttttgatgt cagagcgacc
    49861 agttattttg gcattaaagg gaataacaac caaacgtcgc caagttccat catcgttcgc
    49921 ccctacttta ggcagatggt tggtgtaaag aactagcgtg tgtgagggca cgaagtggaa
    49981 tggatccttg tacttcttct ctgcttgaat ctcatcagtt gaagtaatct gcttcacaac
    50041 ggctgtattg agtcgcatac cctcagccat ctcagaagca atgaccagtc gtttcccttt
    50101 aagctcagca agctcaggac tgacatttcg cttgtttgac atagttaagg catccgcaga
    50161 taatttacct gaatagctac ctagcacacg agcaatggta ttccaaaaag tagacttgcc
    50221 gttcgctccg cctccgtagg caataatcat gtgttcctga tagaccttac cgatagctgc
    50281 cataccaata atttcttgaa cataatcaat taattcttgg tcattacaga aaaaggtagc
    50341 taaagtttcc tgccataatc ccattccctg atcactaggg gagactgcgg taatttttgt
    50401 tatgtaatct tcaggattgt gttcttgttg cccatttatt ccctttcgta aatcataggt
    50461 agcctctggg gtattgagta ataagtcatc actatctaat tctgacaatt ctactgaaag
    50521 aattggttta gctgtattat agacagccat caaattctta tagtcacgat gtttcataac
    50581 aaatttatga aactctttag ctgcaagata agcttttaaa tatttcaatt gaagtggagt
    50641 ttcgactgca ttttctagac gctttcctcc agcctttatg gttaattcat caatacctga
    50701 agactgaagt tgcttatccg cagattccaa gagtgcaatc gcttcagcaa gttgctcatc
    50761 agtaaagtgt acaactgcac ctagtgccaa ctgcttattc tcacgccagt gagttccgtc
    50821 atagtaaaga tagtcagttg cgttggtgta ggccagctta ttagcatatt ctctagcaag
    50881 cacaccagcc tcgcctacat ctgagtaatc atctggtttt aaagtttctc gattgaaagc
    50941 atcgggagcc acataacttt ttgatgtttt tatagttctg ttgtagaatc ggaccgcgct
    51001 cccccaaatg gtatctaact cagctttgtc aagtggcggt acacatttct gtgcctgctc
    51061 atcaaaacca tccctagctt cttgggtcac gcctaaccgt ttgagaattt tcgcagcaaa
    51121 aactgacatc gttgaattac gactcccttg ctggattggt ccacttggag gagtatagaa
    51181 gtctgcatcg aaatcttcct catcttcaat agaaacaact tgaaacaaat cttcatcaat
    51241 agttagccat gaatcatgcc atataacctg tgcatttgga tttccaaaga agaatcgtgc
    51301 cgcatccttg gcatgatcat caaaaaactt gtattgatta cagagttctt ccttcattgc
    51361 tacatagatg tctttatctg ttacctcatt aatttggaag tagatatgaa acttgggtct
    51421 aggtgctttt cctgccttag tctgcatgtg actacggctc gtcaccaaag cgaagttata
    51481 atccgcaaag acgtctttaa ggaattcttc ggtaagccat tcatcaggat tttctgtgtg
    51541 atcattatca atatccatga ctaacacatc tgacttgata aagttggcat tggagcgagt
    51601 attttggaca aaaagacctg ccacatggtc gaattgagct acgttttgta agatagcttt
    51661 atcagtgata gttaccatat ttggatagac cgtagttgtt tgtattcctg tctgtccaga
    51721 atgagatagg gtaaatttca tttgatatgc ctccgtcttt agtttttaaa ttaggaaact
    51781 tgcttcctac cttactaagt aagaaacaga gatgattttc cgcacttccg aaattttttt
    51841 tagaaaagta aaagtttcct attaaatgca caggaaactt ttttatgttc aaaaaattat
    51901 agtgagaagc ggaaaaacac ctcttagatc tacttagtaa gatgtaaggg ataaaaatat
    51961 tccttacaaa acggaaaaat cattcgaaac cttacttagt aagataggag gaccaaatat
    52021 ggtaaacgaa ccatacatcg aacctgatga tgatgtagca gatactctca tcgccatcag
    52081 cgtcatctca aaactactcg ctagaaaaat tatggaggaa gaaaacaatg agcaaaatga
    52141 aagaactgaa tagactgatt catgatatgg aagaaaccgc aaagtactac cttcgcttgg
    52201 tggatgagtt caagaaactc ctcactactg aggatgaaac agcacctaaa tcaaatccac
    52261 caaaaaatga accacaaaag gaaattcaat tggaggatgt ccgtgctgta cttgccacga
    52321 aagcaaaaga tggctataag gaagacgtcc gtgctcttct aaatgcttac ggtgcttctt
    52381 cactctcagt acttgaccca aaacactttg cggcagtact tgaagaagct ggaggaattg
    52441 gtaatgacta accacgccat tctatccgca tctgcatcac atcgttggtt gaattgccca
    52501 ccgtctgctc gtctcaccga agatctgcca gacacaacat ctgattttgc tatcgaaggt
    52561 tcggatgctc acgagttgtg tgcttatcta gtcgagaaag ccttgggtag gaatgcgcgt
    52621 gatccaactg aagatttaac attctacaac gatgagatgc aggaatgtgc agaagaatat
    52681 cgcaactatg tcatggaaca agtcgagaaa gctagaggtt actctcgtga ccctacagtt
    52741 cttatagaac aacgactgga tttttctaag tgggtacctg aaggctttgg aactggagat
    52801 tgcatcatcg tggcagacgg acgtcttcag gttattgatt ataaacatgg acttggtgtt
    52861 caggttgatg cagaccacaa ccctcaaatg atgtgttatg cacttggagc acttgagatg
    52921 tttgatggac tttataattt cgataacgtt accatgacaa tctttcaacc acgaaaacat
    52981 aacatttcta cctttaagat agaaaagact gagctgcttg aatgggctga aaatgtactc
    53041 actccaaaag ctgaacttgc attcaagggt gagggggaga tgcaatctgg taaacactgc
    53101 caattctgta aactcaagaa tgtctgtcgc aaacgtgctg aggataattt ggcactagcc
    53161 aagatggagt ttgcggatcc agcttccctt gacaacgagg acattgcaga gattttgcct
    53221 aaactagacc tgttgatttc atgggcaaac gacatcaaag cttatgcttt aaatcaagca
    53281 acagatggac atcctatccc aggatacaaa ctggttgaag gtcgctctgt tcgtaaattc
    53341 tcagatgagt cagccgttag ccaagcagtg attgaagcag gctatgaccc ttatgagaag
    53401 aaactgctca ctatcactgc catgactaag ttacttggca agaaaacttt taatgacctg
    53461 cttggtggtc ttatcataaa accaagtgga aaaccgacac tcgttcctat tgacgatagc
    53521 cgtcaagaga tgaacctagc aaaaaatgaa tttaaagagg aataactata tgacaaccaa
    53581 agtaataaca ggaccaaaca ctcgcttcag ctacttaaat gccaacgagc caaaatctat
    53641 aaatggtagc actcccaagt acagtgcctc actcatcatc ccaaaagagg atactgccac
    53701 cattaacaaa atcaaggctg ctattgagca agcatataaa gaaggtgagt caaagctcaa
    53761 aggcaatggc aaatcagtac ctgcattatc tactctgaaa actcccctac gagatggtga
    53821 ccttgaacgc cctgatgatg aagcatacaa aaatgcctac ttcgtaaatg ccaactcgcc
    53881 acacaaacct ggtgtggttg atggcaaccg ccaagaaatt atcgatacgt ctgagctata
    53941 ctcaggtatc tatggtcgtg cttctatcac cttctacgca tttaattcca atggcaataa
    54001 agggattgct tgcggtttga ataacttgca aaaattgcgt gatggtgaac ccctcggagg
    54061 acgcactcgt gccgaagatg attttgcgac agaagacgat gatgactttt tgaactagaa
    54121 atggagaatt tggtagatga tgtatacgat tttaacttgt acaattatgg gtctctgggt
    54181 gcttatcggt ctatacttcg ggtatatgac cattagagat gacattcgaa atgaagtgga
    54241 acgaaaggca aagcaaaaca aagaaaaact tagccaaaca ccactcagtc gaaaaaacaa
    54301 atagaacttt aggtggcagt acttctgtca cctttttcag aaaggacaaa ctatgccgat
    54361 taaagaactt agcatcgaca ttgaaaccta ttgcgaaatt gacctacgaa aatctggtgt
    54421 ctatcgctat gcggaagatg acagttttga actcctttta attgcagttt ctgtcgataa
    54481 tggaccagtg actgtttacg actttaataa agagaagtta ccacaagata ttcttgaagc
    54541 tttagtagaa gatagagtca tcaaatgggc attcaacgct tcatttgagc gaatttgcct
    54601 atccaactgg ctcaagaaac atcatcctga attcttatca gatggatttc tctccccagt
    54661 ttcgtggcga tgtagcatga tttggtccgc ctatttagga cttccactct cccttgaagg
    54721 agttggaaca gttctcaaac tcaaagacca aaagatgaga gagggggctg accttattcg
    54781 ctacttctgc ttgccttgta agccaaccaa agtcaatggg ggacgaattc gtaactttcc
    54841 tcatcacgca cctaacaagt ggtctacatt tatcgactac aacagacgtg atgttgaggt
    54901 cgaattggcc atcaaggaac gggtgaaaaa cttcccagta cctagctttg tttggaatga
    54961 gtaccaccag gatcagatta tcaacgaccg cggtattggc atagatgttg actttgtaaa
    55021 agctgcttta aaaatagacg gagagagcaa agccaaaatt caagcagagt taaaaacatt
    55081 aacgggtctt gaaaaaccca actctgttct gcagatgatt agttggttgc gagaacacgg
    55141 agtagcaaca gattctctag acaaaaaagc tgtgaaagaa ttactcaaaa cggttgatga
    55201 aacaactgct caagttctca aacttcgtca gcaagctgcc aaatcaagtg tctccaaata
    55261 ccaggctatg atgaactgtg tttgtaaaga cggtcgagca agaggaatgt ttcaattttt
    55321 cggggctaat cgtacaggtc gttgggctgg tcgcttggta caacttcaga atttaccaca
    55381 gaaccatctt cctgacctaa aggaagctag agaacttttc agaacaggtg acttagaatc
    55441 tactgagcta ctctacgaca cacaagatac cttatctcaa cttatccgaa cagcctttgt
    55501 ccctagtaaa ggaaagaaat tcattgtttg cgacttttca gctatcgaag ctcgtgtact
    55561 ctcccacctg gcaggagaga gatggcgcag taaagtattt gaacaaggga aagacatcta
    55621 ctgtatgtcc gcttctcaga tgtttggagt accagttgaa aaacatggac aaaattctga
    55681 actcaggcaa aaaggaaaaa ttgcagagct tgcttgcggc tatggtggtt cagtcggtgc
    55741 attgaaagcc atgggagcac ttgatatggg actatcagag gaagaactcc aaccacttgt
    55801 taactcatgg cgacaagcaa atccgaatat cgttctctat tggtgggatg tcgataatgc
    55861 tgtaaagact gctgtaaagg aactacttcc aacatctact caaaatattc aatttgaagt
    55921 caaaagtggt atattgttca tcacccttcc ttctggtcgc aaactagcgt atatcaaacc
    55981 aagaattggc gagaaccagt tcggtggaga gtccgtcact tacgaaggaa ctggaactgc
    56041 caaacgttgg gagaggttag aaagctacgg tccaaaattt gtagagaaca ttgttcaagc
    56101 tatcagtaga gacatacttg cgttctctat gaagcaacta aatgatttca agattgtagg
    56161 ccatgtccac gatgaagtaa taatcgaatg tccaattgaa caaaaacttg atgaagttgc
    56221 atcattaatg gggatagcac ctgactggtt gtctgatatt aatcttaggg ctgatggata
    56281 tgaatgcttt ttctatcaaa aagactagca aaaaatcgcc acctcgtaat tgagatggcg
    56341 attctgttat ttattaaatt tgttgtaaag ctctaaccct tctttctgag tattttttac
    56401 tttcttatat ccagcagatt tctgtactcc tagtttttca aagatttcct tattctcgta
    56461 accatcaaat aacatttcca aaatatctgg tgcttgaaaa tttgattctg caagttttgc
    56521 tttcaaaaac tcaaactgat ccatgaatag ataaagctca atgtcatcat ctatcattgg
    56581 taaatcttgt ttctctgtga atgcttccca agatgaaatc ttaggagcat ttttacttgg
    56641 cttacgataa tctttaagat aatcattaac tgagttattg taccaccaga ccatctgttc
    56701 atagtcctct tctgcgactg gaacaaaggc agttagtatt ggaataccca taatacgaca
    56761 ttgacgaaac gtaccacgta gcaaacctga atggcgtgaa tccatgtaat aatcctgcac
    56821 gaacatgggt gctagtactt cactttcagt tggttgtact ccagttgatg aagattgagt
    56881 ttggcagtag ttgaaaaagt tgacattgat tgtcatgata aattggcttc ccagttaata
    56941 ccgaaagcac acatgacaaa tcaaggcatg caaaaaatat tcttgaccgc atagttactt
    57001 tcctctatgt tatcggtcag ccaatttcac aagctgaaaa aagtaatcaa taccaaaaca
    57061 tctgaaatta tggtcgtcgt cacgactccg tttttgtaat gataatcgtt tagagatatc
    57121 tcatctctta gttaaattgt aatagaaaat aatccgta
//
LOCUS       DAUDWO010000006        56287 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.006, whole genome shotgun sequence.
ACCESSION   DAUDWO010000006 DAUDWO010000000
VERSION     DAUDWO010000006.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 56287)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 56287)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..56287
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.006"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(171..269)
                     /gene="ffs"
                     /locus_tag="VHC05_000325"
     ncRNA           complement(171..269)
                     /ncRNA_class="SRP_RNA"
                     /gene="ffs"
                     /locus_tag="VHC05_000325"
                     /product="signal recognition particle sRNA small type"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00169"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00169"
     gene            469..1701
                     /locus_tag="VHC05_000326"
     CDS             469..1701
                     /locus_tag="VHC05_000326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-layer protein"
                     /protein_id="HEQ5401670.1"
                     /translation="MGVMMKQKIKILTVIGLMTVGMSACHNTSKPSNTDSVFSLTGKK
                     RQQIVKQVRQRYYFQQLSKTEQENYLTLYDSLAQFREIISLTPASKKSLIKTIDAFVM
                     DNPEFYWITSADYRFEFSDQTVFVTFPIPEDAKNVYQDLQAIGNDIVANTPSKDRYEQ
                     VKYFYEVIIRDTDYNKKAFEAYQSGSQAQVASNQDIKSVFIDHLSVCNGYAQAFQFLC
                     QKAGIPVAYIRGTGTSQQPQQSFAHAWNAVQINNTYYGVDVTWGDPVFDNHLSHQKQG
                     TINYSFLCLPDYLMALSHQPSKDIAFNTKERFENVWTIPSCTDDSLLYSKRHQSYIST
                     FDSDAILASLENQLLNRQEQLSLQFAHQDDYQQMVTDLTTNQTGYHNLFNQYWNNYTG
                     FTYGLLPETLSISFASRN"
     gene            complement(2315..2830)
                     /locus_tag="VHC05_000327"
     CDS             complement(2315..2830)
                     /locus_tag="VHC05_000327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside deaminase"
                     /protein_id="HEQ5401671.1"
                     /translation="MPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRG
                     HNAREESNQAIMHAEMMAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLARIPHV
                     IYGASNQKFGGADSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKIAK
                     HLIKEQSDPFD"
     gene            complement(2830..3609)
                     /locus_tag="VHC05_000328"
     CDS             complement(2830..3609)
                     /locus_tag="VHC05_000328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEQ5401672.1"
                     /translation="MKLTTLGSWGAYPYQDAGTTSYLVTGHDGFQLLMDAGSRALNEL
                     EKEISPLDLDAVIISHYHPDHVADLGVLRHYFQLYPKHLWQPKVLPIYGHDEDRHEFA
                     KLSIPDVSEGRAYDVTGVEQIGPFDITFLKTVHPVVCYAFRIVERATGQVLVFTGDSG
                     YFEGLADFAKEADLFLADVYLYEGNENHMAHLTSKEAGLMASQAGVKKLVLTHMPPVP
                     PEGINSKNHLEVLRQETQAYAGNIPVDLALPHKSWNLGSLS"
     gene            complement(3749..4288)
                     /locus_tag="VHC05_000329"
     CDS             complement(3749..4288)
                     /locus_tag="VHC05_000329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin transporter BioY"
                     /protein_id="HEQ5401673.1"
                     /translation="MFTTKELVKVAMMTTLIIILGFIPAIPLGFIPVPIVLQNLGVML
                     AGLMLGGKKGTLSVFLFLVIGLFLPVFSGSRTTIPVLMGPSAGYVIAYLLVPIVFSLL
                     YRNWFSKSTPLAFLALFISGVLLVDVMGAIWLAAYTGMPLMTSLLSNLVFIPGDTIKA
                     IIATIIAVKYKDSFLNTKQ"
     gene            complement(4292..4603)
                     /locus_tag="VHC05_000330"
     CDS             complement(4292..4603)
                     /locus_tag="VHC05_000330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003045539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401674.1"
                     /translation="MTDCFGIDLDQEYRCLHYHTPLDIVGLKCAFCQTYYACYHCHDQ
                     LADHAFVPTGHQETSPVICGHCRKLLSLAEYGCGCCPYCQSPFNPACHRHKDIYFLKE
                     S"
     gene            complement(4820..5962)
                     /gene="tgt"
                     /locus_tag="VHC05_000331"
     CDS             complement(4820..5962)
                     /gene="tgt"
                     /locus_tag="VHC05_000331"
                     /EC_number="2.4.2.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="HEQ5401675.1"
                     /translation="MTDYPIKYRLIKTEKHTGARLGEIITPHGTFPTPMFMPVGTQAT
                     VKTQSPEELKAIGSGIILSNTYHLWLRPGDELIARSGGLHKFMNWDQPILTDSGGFQV
                     YSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYD
                     YVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAADLVAMDFPGYSI
                     GGLAVGESHEEMNAVLDFTTPLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTR
                     IARNGTCMTSEGRLVVKNAKFAEDFTPLDHDCDCYTCQNYSRAYIRHLLKADETFGIR
                     LTSYHNLYFLVNLMKKVRQAIMDDNLLEFRQDFLERYGYNKSNRNF"
     gene            6181..7044
                     /locus_tag="VHC05_000332"
     CDS             6181..7044
                     /locus_tag="VHC05_000332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF975 family protein"
                     /protein_id="HEQ5401676.1"
                     /translation="MSIKAIKSQARDTLKNLSGKYLLFLIPTLLFMFHFGIEIHQGYV
                     LSSGIEVSLAASYFPLLLGLILSLFILSASFTMIDVVRHFRQKVSFAESTTAFSKEFF
                     GNLLVLAITKWLFFLIWSLIWFFGLFIFLSGLSAFLVNAKSGSSTVISLIFLLFGAVL
                     SLIGFGIYINRYYAYSLSEYLLYDKVKEGTYLGAIAVIKTSVAMMKGYKWKLFFLQLS
                     FTGWFLLNIVTFGLLNIYLLPYFTTANVIFYDQLKKRFKDKDDPIEGEHLSLHQLNKK
                     PTPMMYDDQKD"
     gene            complement(7146..7613)
                     /gene="perR"
                     /locus_tag="VHC05_000333"
     CDS             complement(7146..7613)
                     /gene="perR"
                     /locus_tag="VHC05_000333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide-responsive transcriptional repressor
                     PerR"
                     /protein_id="HEQ5401677.1"
                     /translation="MDIHSHQQALDAYENVLEHLREKHIRITETRKAIISYMIQSTEH
                     PSADKIYRDLQPNFPNMSLATVYNNLKVLVDEGFVSELKISNDLTTYYDFMGHQHVNV
                     VCEICGKIADFMDVDVMDIAKEAHEQTGYKVTRIPVIAYGICPDCQAKDQPDF"
     gene            complement(7665..8120)
                     /locus_tag="VHC05_000334"
     CDS             complement(7665..8120)
                     /locus_tag="VHC05_000334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-binding protein"
                     /protein_id="HEQ5401678.1"
                     /translation="MIYSFQNPSEAVLKAYLESAKTIAVVGLSDRKDTAAYGVAKFMQ
                     AMDYRIIPVNPKLAGQLILGEKVYASIKAIPFEVDIVDVFRRSEFLPEVARDFLAGQA
                     KVFWAQLGLENQEAQTILRSAGKEAIVMNRCLKIDYLQLVAKPECITNH"
     gene            complement(8307..10949)
                     /gene="polA"
                     /locus_tag="VHC05_000335"
     CDS             complement(8307..10949)
                     /gene="polA"
                     /locus_tag="VHC05_000335"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase I"
                     /protein_id="HEQ5401679.1"
                     /translation="MENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGF
                     HLMLDHMMKRVQPTHVLVAFDAGKTTFRTEMYADYKAGRAKTPEEFREQFPYIREMLT
                     ALGIAYYELEHYEADDIIGTLDKMAERTEVPFDVTIVSGDKDLIQLTDENTVVEISKK
                     GVAEFEEFTAAYLMEKMGLTPNQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEFGS
                     LEGIYEHIDGFKTSKMKENLINDRDQAFLSKTLATINTASPITIGLDDIVYNGPDVAS
                     LSQFYDEMDFVQLKKGLASQMPQEPVAVISYQEVTNVSADLFSAEDIFYFETLRDNYH
                     REAIIGFAWGHGEQIYASTDLSLLATDSFKQVFQKPIATYDFKRSKVLLSHLGIELVA
                     PSYDARLANYLLSTVEDNELSTIARIFTDISLEEDDTVYGKGAKRAVPDKDVLLEHLA
                     RKVKVLLDSKSQMLDKLTAHEQLDLYQNIELPLANVLAKMEIEGIKVNRTTLQDMAEQ
                     NKVIIEALTQEIYDMAGQEFNINSPKQLGSILFEKMQLPLEMTKKTKTGYSTAVDVLE
                     RLAPIAPIVAKILDYRQITKLQSTYVIGLQDYILADGKIHTRYVQDLTQTGRLSSVDP
                     NLQNIPIRLEQGRLIRKAFTPSHEDAVLLSSDYSQIELRVLAHISGDKHLIAAFNEGA
                     DIHTSTAMRVFGIDKAADVTANDRRNAKAVNFGIVYGISDFGLSNNLGITRKQAKSYI
                     DTYFERYPGIKAYMENVVREAKDKGYVETLFKRRRELPDINSRNFNVRSFAERTAINS
                     PIQGSAADILKIAMINLDKALQAGGFRAKMLLQVHDEIVLEVPNDELTAIKKLVKDTM
                     EAAVDLAVPLCVDESTGQSWYEAK"
     gene            complement(11080..12807)
                     /locus_tag="VHC05_000336"
     CDS             complement(11080..12807)
                     /locus_tag="VHC05_000336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003060437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease/substrate binding
                     protein"
                     /protein_id="HEQ5401680.1"
                     /translation="METILQTKLPVAQLVEQLTEWLTKTFSGLFDIMQVVGSFLMDWM
                     TKTLLFIHPLLFIVLVTAGMFFLAKKKWPLPTFTLLGLLFIYNQGLWKQLMNTFTLVL
                     VASLISVLIGIPLGIWMAKNATVRQIVNPILDFMQTMPAFVYLIPAVAFFGIGMVPGV
                     FASVIFALPPTVRFTNLAIRDIPTELIEASDAFGSTGKQKLFKVELPLAKNTIMAGVN
                     QTMMLALSMVVTGSMIGAPGLGREVLSALQHADIGSGFVSGLALVILAIVLDRMTQLF
                     NSKPQEKAKAGKTNKWIGLAALAVFLIAALGRGIMAMTSGMADKGETVNIAYVQWDSE
                     VASTHVIAEVLKNEGYHVTLTPLDNAVMWQTVANGNADFSTSAWLPVTHGQQYQKYKS
                     KLDDLGPNLKGTKLGLAVPKYMTDVNSIEDLSKQADQKITGIEPGAGIMAAAKKTLKE
                     YHNLSSWELVAASTGAMTTSLDQAIKKKDPIVVTAWSPHWMFAKYDLKYLKDPKETFG
                     STENINTIARKGLKKDLPNVYKIIDKFHWTQKDMEAVMLDINKGMSPEAAAKKWVEAN
                     KSKVSSWTK"
     gene            complement(12823..14019)
                     /locus_tag="VHC05_000337"
     CDS             complement(12823..14019)
                     /locus_tag="VHC05_000337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine betaine/L-proline ABC transporter
                     ATP-binding protein"
                     /protein_id="HEQ5401681.1"
                     /translation="METILEVKHLSKIFGKKQKAALEMVKTGKNKSEIFKKTGATVGV
                     YDASFEVKKGEIFVIMGLSGSGKSTLVRMLNRLIEPSAGSILLEGKDISTMSADQLRE
                     VRRHDINMVFQSFALFPHKTILKNTEFGLELRGVPKEERQRLAEKALDNSGLLDFKDQ
                     YPNQLSGGMQQRVGLARALANSPKILLMDEAFSALDPLIRREMQDELLDLQDSMKQTI
                     IFISHDLNEALRIGDRIALMKDGQIMQIGTGEEILTNPANDFVREFVEDVDRSKVLTA
                     QNIMIKPLTTTVELDGPQVALNRMHNEEVSMLMATNRRRQLVGSLTADAAIEARKKGL
                     PLSEVIDRDVRTVSKDTIITDILPLIYDSSAPIAVTDDNNRLLGVIIRGRVIEALANI
                     SDEDLN"
     gene            complement(14507..15598)
                     /gene="ulaG"
                     /locus_tag="VHC05_000338"
     CDS             complement(14507..15598)
                     /gene="ulaG"
                     /locus_tag="VHC05_000338"
                     /EC_number="3.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ascorbate 6-phosphate lactonase"
                     /protein_id="HEQ5401682.1"
                     /translation="MTKVQDITRESWILNTFPEWGTWLNEEIEQEVVPADNFAMWWLG
                     NCGIWIKTPGGANVVMDLWSNRGKATKQVKDMVRGHQMANMAGARKLQPNLRAQPMVI
                     DPFMINELDYYLVSHYHSDHIDINTAAAIINNPKLDHVKFVGPYECGEVWKNWGVPKD
                     RIMILKPGDSFEFKDIKITAVESFDRTCLVTLPIQGADAQDGDLAGLAITDDDMARKA
                     VNYIFETPGGTIYHGADSHFSNYFAKHGRDYDIDVVLNNYGENPIGIQDKMTSVDLLR
                     MAENLRAKVVIPVHYDIWSNFMASTDEILELWKMRKERLQYDFHPFIWEVGGKYTYPQ
                     DQNRIEYHHPRGFDDCFLEDSNIQFKALL"
     gene            complement(15851..17497)
                     /locus_tag="VHC05_000339"
     CDS             complement(15851..17497)
                     /locus_tag="VHC05_000339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HEQ5401683.1"
                     /translation="MMILDKKSYDLLSYLLKLETPETVMAISHALNQSRRKVYYQLDK
                     INKALPKGVDQIISYPRLGILLTADQKAACRLLLEEVTDYNYVMKSDERRRLSSIYIA
                     VSTERVTIDKLMQINDVSRNTILNDLTELREELEDKQYKIQLHATKARGYYFGCHPMA
                     LIQYLYKLLVDVYQGGNTSFIDIFNRKLSEIQGLSVYFSKDILTYFHEYLFLSQASLG
                     KTINTQDSQFMLQILPFMLLSYRNMRLDSETKSALKQEFHLIWKRKEYHIAQDLAREL
                     YHNFKLHLDDIEVSMVAMLMLSFRKDQDHHVESQDYDDMRATISHFIDQLESRYQLHF
                     THKQDLLKQLTTHCKALVYRKAYGIFLVNPLTDHIKEKYEELFAMTQSCATILEQDWT
                     ISLTDDDIAYLTIHLGGELRHNNTEQEKTKLVIVSDDGIGIQKLLFKQCQRYLANGQI
                     EAVFTTEQYQSVYDLLAVDMIVATTDTLKTKIPMLIVNPILSDDDIIKLIRFSKQGRL
                     SEHSRFSTELTKAIEAVVKDESDRYALVSKIEKLIHRELL"
     gene            complement(17822..18526)
                     /locus_tag="VHC05_000340"
     CDS             complement(17822..18526)
                     /locus_tag="VHC05_000340"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003045586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="HEQ5401684.1"
                     /translation="MAKNLQEMRERVCAANKSLPQHGLVKFTWGNVSEVCRELGRIVI
                     KPSGVDYDLLTPENMVVTDLDGNVVEGDLNPSSDLPTHVELYKAWPEVGGIVHTHSTE
                     AVGWAQAGRDIPFYGTTHADYFYGPVPCARSLTKAEVDGAYEQETGNVILEEFSKRGL
                     DPMAVPGIVVRNHGPFTWGKTPEQAVYHSVVLEEVAKMNRLTEQINPRVEPAPRYIMD
                     KHYLRKHGPNAYYGQK"
     gene            complement(18528..19391)
                     /locus_tag="VHC05_000341"
     CDS             complement(18528..19391)
                     /locus_tag="VHC05_000341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 3-epimerase"
                     /protein_id="HEQ5401685.1"
                     /translation="MARPIGIYEKATPKQFTWRERLQFAKDLGFDFVEMSVDESDARL
                     ARLEWTKEERLDLVKAIYETGIRIPTICFSGHRRYPLGSNDPATEAKSLKLMKQCIEL
                     AQDLGVRTIQLAGYDVYYEEKSPETRARFIKNLRQSCDWAEEAQVMLSIEIMDDPFIN
                     SIEKYLAVEKEIDSPYLFVYPDAGNVSAWHNDLWSEFYNGHKSIAALHLKDTYAVTET
                     SKGQFRDVPFGQGCVDWQELFAVLKKTNYNGPFLIEMWSENCDTVEETKAAIKEAQDF
                     LYPLIEKAGLA"
     gene            complement(19396..20058)
                     /locus_tag="VHC05_000342"
     CDS             complement(19396..20058)
                     /locus_tag="VHC05_000342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-keto-L-gulonate-6-phosphate decarboxylase
                     UlaD"
                     /protein_id="HEQ5401686.1"
                     /translation="MTHIPNLQVALDHSDLQGAVKAAVAVGHEVDVIEAGTVCLLQVG
                     SELVEVLRSLFPEKIIVADTKCADAGGTVAKNNAKRGADWMTCICCATIPTMEAALKA
                     IKEERGDRGEIQIELYGDWTYEQAQLWLDAGISQAIYHQSRDALLAGETWGEKDLNKV
                     KKLIDMGFRVSVTGGLDVDTLKLFEGVDVFTFIAGRGITEAEDPAAAARAFKDEIKRI
                     WG"
     gene            complement(20165..20650)
                     /locus_tag="VHC05_000343"
     CDS             complement(20165..20650)
                     /locus_tag="VHC05_000343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEQ5401687.1"
                     /translation="MNLKQAFIDNNSIRLGLSADTWQEAVQLAVQPLIDSKAVTSAYY
                     DAIIASTEKYGPYYVLMPGMAMPHAEAGLGVNRNAFALITLTKPVTFSDGKEVSVLLT
                     LAATDPSIHTTVAIPQIVALFELDNAIERLVACQSPKEVLEMVEESKNSPYLEGLDLD
                     A"
     gene            complement(20773..21051)
                     /locus_tag="VHC05_000344"
     CDS             complement(20773..21051)
                     /locus_tag="VHC05_000344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEQ5401688.1"
                     /translation="MVKVLTACGNGMGSSMVIKMKVENALRQLGVTDIQSASCSVGEA
                     KGLASGYDIVVASNHLIHELDGRTKGHLVGLDNLMDDNEIKTKLQEVL"
     gene            complement(21122..22555)
                     /locus_tag="VHC05_000345"
     CDS             complement(21122..22555)
                     /locus_tag="VHC05_000345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEQ5401689.1"
                     /translation="MEMLLAPLNWFSQNILQNPAFFVGLLVLIGYLLLKKPIYEVFAG
                     FVKATVGYLILNVGAGGLVTTFRPILVALAKKFELKAAVIDPYFGLAAANTKLEEMGF
                     ISVATTALLIGFGVNILLVALRKVTKVRTLFITGHIMVQQAATISVFVLLLIPQFQNA
                     FGAWAVGIICGLYWAVSSNMTVEATQRLTGGGGFAIGHQQQFAIWFVDKVAPIFGKKE
                     ENLDNLKLPTFLNIFHDTVVASATLMLVFFGAILAVLGPDIMSNVELIGPGAFNPAKQ
                     AFFMYILQTSLTFSVYLFILMQGVRMFVSELTNAFQGISSKLLPGSFPAVDVAASYGF
                     GSSNAVLSGFAFGLIGQLITIALLVIFKNPILIITGFVPVFFDNAAIAVYADKRGGWK
                     AAVALSFISGILQVALGAVAVGLLGLTGGYHGNIDLVLPWLPFGYLFKFLGIAGYVLV
                     CIFLLAIPQLQFAKAKDKEAYYRGEAQ"
     gene            complement(22862..25363)
                     /locus_tag="VHC05_000346"
     CDS             complement(22862..25363)
                     /locus_tag="VHC05_000346"
                     /EC_number="6.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014639013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="HEQ5401690.1"
                     /translation="MTFYDHTAIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPS
                     GAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTA
                     ENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
                     ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKD
                     MQRNWIDKSTGANVTFKVKDTDKDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQ
                     AEAVADYKRQASLKSDLARTDLAKEKTGVWTGSYAINPVNGNEMPVWIADYVLASYGT
                     GAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVEEAAFTEDGLHINSDFLDGLDKASA
                     IAKMVEWLEAEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLV
                     LPVTKDIRPSGTGESPLANVTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPH
                     NTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLFN
                     QGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDV
                     VEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALD
                     KVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDKLFSDYAKGFVQLIAPFAPHL
                     GEELWQALTASGESISYVPWPSYDESKLVENDVEIVVQIKGKVKAKLVVAKDLSREEL
                     QEVALANEKVQAEIAGKDIIKVIAVPNKLVNIVIK"
     gene            complement(25575..26714)
                     /locus_tag="VHC05_000347"
     CDS             complement(25575..26714)
                     /locus_tag="VHC05_000347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent transferase"
                     /protein_id="HEQ5401691.1"
                     /translation="MRENTTLLHGYTVIDEFTGAASVPIYQTSTFHNSELYCPSQKHL
                     YTRFSNPTTEALEDGLACLEKATYAVAYASGMAAISTVLMLLKAGDHVIFPLEVYGGT
                     CQFATAILPNYQIETSFVDMADLATVKASIRPNTRMIYLETPSNPLLKICDISELVQL
                     AKAYGVLTVADNTFMTSLYQEPLAMGVDIVVESVTKFINGHSDVVAGLAATNNEAIYN
                     QLKLFQKNFGAIVGVEDAWLILRGMKTMGIRMEQAVKNAQQLANYLAKHPKVLKVHYP
                     GLDSHPNHDTHLQQAKNGGAVLSFELASKEELMTFTHRIQLPILAVSLGGVESILSHP
                     ATMSHACLSSQARLEQGVVDGLLRLSCGVENIEDLLADFEQALAF"
     gene            27198..27475
                     /locus_tag="VHC05_000348"
                     /pseudo
     CDS             27198..27475
                     /locus_tag="VHC05_000348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284461.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            27618..27785
                     /locus_tag="VHC05_000349"
     CDS             27618..27785
                     /locus_tag="VHC05_000349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401692.1"
                     /translation="MKKKLSLFMIATAAVASLSLATLGSHQTVSANDASYSNGFYGHT
                     GPDSWLLYTVW"
     gene            28197..28427
                     /locus_tag="VHC05_000350"
     CDS             28197..28427
                     /locus_tag="VHC05_000350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401693.1"
                     /translation="MKKKLSLFMIATAAVVGLSLATPENQTVSANAQTPAVQNCENGC
                     CDRPFFGYCGPFSWLYYNTRYFLGYSDTATNQ"
     gene            complement(28711..29064)
                     /locus_tag="VHC05_000351"
     CDS             complement(28711..29064)
                     /locus_tag="VHC05_000351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401694.1"
                     /translation="MKQQSYQPLRFVYLLVALFAALLLIARPVMADEENDPWILGYKQ
                     GLTKGKEAGKAADWTDLTPPDQEPPSDIEEANKEGYKDGYRDGYNEGFGESYPLLIPV
                     KFIWGIILHWWGKLI"
     gene            complement(29319..31034)
                     /gene="slo"
                     /locus_tag="VHC05_000352"
     CDS             complement(29319..31034)
                     /gene="slo"
                     /locus_tag="VHC05_000352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_095889392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cholesterol-dependent cytolysin streptolysin O"
                     /protein_id="HEQ5401695.1"
                     /translation="MSNKKTFKKYSRVAGLLTAALIIGNLVTANAESNKQNTASTETT
                     TTNEQPKPESSELTTEKAGQKTDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDKKKSE
                     EDHTEEINDKIYSLNYNELEVLAKNGETIENFAPKEGVKKADKFIVIERKKKNINTTP
                     VDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDKATVEVN
                     DPTYANVSTAIDNLINQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDG
                     TLGIDFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFAKSVTFKELQRKGVSNEA
                     PPLFVSNVAYGRTVFVKLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAV
                     VLGGDAAEHNKVVTKDFDVIRNVIKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRT
                     EYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNWYSKTS
                     PFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGSTLSPYG
                     SITYK"
     gene            complement(31058..31543)
                     /locus_tag="VHC05_000353"
     CDS             complement(31058..31543)
                     /locus_tag="VHC05_000353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD glycohydrolase inhibitor"
                     /protein_id="HEQ5401696.1"
                     /translation="MYKVPKGLEHYQKMFQKEVTVNDLKKYLIGSDKEYRITRRDSYM
                     GDISDPEVILEYGVYPAFIKGYTQLKANIEEALLEMSNSGQALDIYQAVQTLNAENML
                     LNYYESLPFYLNRQSILANMTKVLKDAHIREAMAHYKLGEFAHYQDTMLDMVERTIKT
                     F"
     gene            complement(31548..32903)
                     /gene="nga"
                     /locus_tag="VHC05_000354"
     CDS             complement(31548..32903)
                     /gene="nga"
                     /locus_tag="VHC05_000354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotine adenine dinucleotide glycohydrolase"
                     /protein_id="HEQ5401697.1"
                     /translation="MRNKKVTLAHIVAKTSVAIALAGAMGSSLLANSTTYAVSGKENK
                     KSDVKYETTKVMEANATSSKEDNHVMHTLDGSMSTVWEENSPGGGVGEVLSYKFASPM
                     HIGRILIVNGDTSSKENYYKKNRIAKADVKYYNGNKLVLFQKIELGDTYTKKPHHIEI
                     DKKLDVDRIDIEVTEVHQGQNKDILALSEVTFGNMERDLFEKKFKEIKDKWVTDKQAD
                     EFIETADKYADKAVQMSAVASRAEYYRMYVSRKYQYKKEFVEKLKQVYKESGASHVTS
                     KKDLMLAFDDAKRKSTIGRQENGLFVTSFAEDMALLFTDQGKLKSADQIENIKGVDSG
                     KYSDGVYQYEYDSELTKNIDKLGYIRTASGDTPGANSLNIPGCQTWSGKHIENSESEL
                     IFPSISVKDLKSKAVLAEIDAKGYFEIIDPTIIAPNGDHKKVTGRFKIKKMQDRMQDR
                     K"
     gene            complement(33274..33813)
                     /gene="nusG"
                     /locus_tag="VHC05_000355"
     CDS             complement(33274..33813)
                     /gene="nusG"
                     /locus_tag="VHC05_000355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003100341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusG"
                     /protein_id="HEQ5401698.1"
                     /translation="MLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEI
                     PTQTVNVEKNGQTKEIEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKP
                     TPLLEEEIRAILLSMGQTIDVFDTNIKEGDVVQIIDGAFMGQEGRVVEIENNKVKLML
                     NMFGSETVAEVELYQIAEL"
     gene            complement(33986..35029)
                     /locus_tag="VHC05_000356"
     CDS             complement(33986..35029)
                     /locus_tag="VHC05_000356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family protein"
                     /protein_id="HEQ5401699.1"
                     /translation="MNKKVMSLGLVSTALFTLGGCTNNSAKQTTDNSLKIAMITNQTG
                     IDDKSFNQSAWEGLQAWGKENKLEKGKGYDYFQSANESEFTTNLESAVTNGYNLVFGI
                     GFPLHDAVEKVAANNPDNHFAIVDDVIKGQKNVASITFSDHEAAYLAGVAAAKTTKTK
                     QVGFVGGMEGDVVKRFEKGFEAGVKSVDDTIKVRVAYAGSFADAAKGKTIAAAQYAEG
                     ADVIYHAAGGTGAGVFSEAKSINEKRKEEDKVWVIGVDRDQSEDGKYTTKDGKSANFV
                     LTSSIKEVGNALVKVAVKTSEDQFPGGQITTFGLKEGGVSLTTDALTQDTKKAIEAAK
                     KAIIEGTITVPEN"
     gene            complement(35356..36648)
                     /locus_tag="VHC05_000357"
     CDS             complement(35356..36648)
                     /locus_tag="VHC05_000357"
                     /EC_number="6.3.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000205037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthase"
                     /protein_id="HEQ5401700.1"
                     /translation="MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIV
                     IDGKKFKLHLIPSGIFFPQKISVIGNGVVVNPKSLVKELAYLHNEGVTTDNLRISDRA
                     QVILPYHIQLDQLQEDAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFAERL
                     RINLAEKNRLFEKMYDSTPLDFDAIFEEYYAYGQEIKQYVTDTSVILNDALDAGKRVL
                     FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGP
                     FPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVL
                     SGLDTVKICVAYDLDGKRIDYYPANLEQLKRCKPIYEELPGWQEDITGVRSLEELPEN
                     ARNYVRRVGELVGVRISTFSVGPGREQTNILESVWASI"
     gene            37086..37964
                     /locus_tag="VHC05_000358"
     CDS             37086..37964
                     /locus_tag="VHC05_000358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401701.1"
                     /translation="MIRKHDRTSTKKKSLNWIWLIIAFFMISSFIGGSSFTESLLDIL
                     PAIAIGGTGYAIFRVRSHQKRLAKAKIAKQLEDLKAKIQLADRKVRLLDTYLADHDDF
                     QYNVLAQQLLPQLSDIKAKAITLKDQLDPKIYRRITKKANDVESDITLQLETLQIATT
                     LNPQPLKTPSPNLINKAPELKPYYDNIQTDHQAILAKIQGADNQEELLALHEANMRRF
                     EDILTGYLKIKEEPKNYYNAAARLEQAKQAIQQFDEDLDETLRRLNESDLKDFDISLR
                     IMQGATQRRTTHHQKD"
     gene            37977..39239
                     /locus_tag="VHC05_000359"
     CDS             37977..39239
                     /locus_tag="VHC05_000359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="toxic anion resistance protein"
                     /protein_id="HEQ5401702.1"
                     /translation="MADFNFDIDQIADNAVVKTDKTTDIISDLPTDTNGQISFFEKLS
                     ADQQTAITAKAPALVDTFLADQNALLDFGQSAVEGVNATVNHILAEQKKLQIPQVDDL
                     LKSTNRELNGFIAKYKDATPVDLDKKPNFLQKLFKQSRDTLKEFYFDSQNIEQKMDSM
                     AAAVVKQEDTLARNIVSAELLIEDNTKSIEHLVGVIAFIEASQKEASQRAAALQKDLK
                     TKDSATPDYQIKADLLARTTEVINTLEQQHTEYLSRLYVAWATTPQMRNLVKVSSDMR
                     QKLGMLRRNTIPTMKLSIAQLGMMQQSVKSGMTADAIINANNAALQMLAETSKEAIPA
                     LEQSAQNPTLSMKSVTSLAESLVAQNNGIIAAIDHGRKERAQLESAIIRSAETINDSV
                     KLRDQNIVQALLSEGKETQKTIDKTTHA"
     gene            complement(39359..39985)
                     /locus_tag="VHC05_000360"
     CDS             complement(39359..39985)
                     /locus_tag="VHC05_000360"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit D"
                     /protein_id="HEQ5401703.1"
                     /translation="MARLNVKPTRMELSNLKNRLKTATRGHKLLKDKRDELMRRFVDL
                     IRENNELRQTIEKELAANMKEFVLAKASENSLMVEELFAVPVHEVTLWIDIENIMSVN
                     VPKFHVQSNTAREQEQGEFAYSYLSSNSEMDNTIQKTKELLEKLLRLAEVEKTCQLMA
                     DDIEKTRRRVNGLEYSIIPQLEETIHYIELKLEEAERASLVRIMKITS"
     gene            complement(40030..41445)
                     /locus_tag="VHC05_000361"
     CDS             complement(40030..41445)
                     /locus_tag="VHC05_000361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit B"
                     /protein_id="HEQ5401704.1"
                     /translation="MSVLKEYRTVSEVVGPLMIVDQVAGVHYNELVDITLHNGERRKG
                     QVLEVQGDKAMVQLFEGSTGINLAKTKVRFTGHPLELAVSEDMVGRIFDGMGQPIDGG
                     PELIPEKYLDIDGQAINPVARDYPDEFIQTGISAIDHLNTLVRGQKLPVFSGSGLPHN
                     ELAAQIARQATVLNSDDNFAVVFAAMGITFEEAEFFMNDLRETGAIDRSVLFINLAND
                     PAIERIATPRIALTTAEYLAYEKGMHVLVIMTDMTNYCEALREVSAARREVPGRRGYP
                     GYLYTNLSTLYERAGRLIGKKGSVTQIPILTMPEDDITHPIPDLTGYITEGQIILSQE
                     LYKNGFRPPINVLPSLSRLKDKGSGEGKTRQDHAATMNQLFAAYAQGKQAKELAVVLG
                     ESALSETDKLYVAFTNRFEEEYINQGFYTNRSIEESLDLGWELLSILPRTELKRIKDD
                     MLDRYLPKADTTMTKVFVAND"
     gene            complement(41446..43221)
                     /locus_tag="VHC05_000362"
     CDS             complement(41446..43221)
                     /locus_tag="VHC05_000362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit A"
                     /protein_id="HEQ5401705.1"
                     /translation="MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRR
                     DQASIQVYEETSGIGPGEPVVTTGCPLSVELGPGLISEMFDGIQRPLDRFQKATDSDF
                     LIRGVAIPSLDRKAKWAFIPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLV
                     AIHAGDFTVTDTVYEIKQEDGSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVID
                     TFFPVTKGGAAAVPGPFGAGKTVVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPE
                     LIDPNTGQSIMERTVLIANTSNMPVAAREASIYTGITIAEYFRDMGYSVAIMADSTSR
                     WAEALREMSGRLQEMPGDEGYPAYLGSRIAEYYERAGRVRTLGSQEREGTITAIGAVS
                     PPGGDISEPVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYQDDVGSYIDRKQ
                     QSNWSNKVTRAMAILQREASLEEIVRLVGLDSLSEQDRLTMAVARQIREDYLQQNAFD
                     SVDTFTSFPKQEAMLTNILTFNEEASKALSLGAYFNEIMEGTAQVRDRIARSKFIPEE
                     NLEQIKGLTQKVTKEIHHVLAKGGI"
     gene            complement(43422..43742)
                     /locus_tag="VHC05_000363"
     CDS             complement(43422..43742)
                     /locus_tag="VHC05_000363"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit F"
                     /protein_id="HEQ5401706.1"
                     /translation="MTKTLYKVGVIGNRDVILPFQMIGFQTFPVIKPQDAINQLRQLA
                     MEDYGIIYITEDIAAAIPEALTHYDNQVLPAVIPLPTHQGAQGIGLSRIQAMVEKAVG
                     QNIL"
     gene            complement(43739..44737)
                     /locus_tag="VHC05_000364"
     CDS             complement(43739..44737)
                     /locus_tag="VHC05_000364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATPase subunit"
                     /protein_id="HEQ5401707.1"
                     /translation="MPTFLELNTTISVKEKELLTKEQFDKLLQAPNTTTLARLLHQSV
                     YHLTVDDLNDLDRLESILMAELTKTYRWAFAETPQPDIVQLFTLRYTYHNVKVLLKAK
                     ASQADLSHLLLPIGDKPLAALEHLIRTMTSDEFPKEVVTEIQSIWAEYQDYQDIRVLE
                     IGTDLAYFKALKQIAQRLEDPVFQQAVLIVIDLYNLITVRRAKSQNKPISFMMQLLSD
                     EASRPSKTFITLEDDKDLMTWFENVTPDSYMTALKPYSEKLRQGTLQTTELEYLVDEC
                     LYHLFAKAKYQVDGPYVLARFLLAKSFEVKNLRLLAAALANDLPKERVIERMRPIA"
     gene            complement(44753..45337)
                     /locus_tag="VHC05_000365"
     CDS             complement(44753..45337)
                     /locus_tag="VHC05_000365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATPase V"
                     /protein_id="HEQ5401708.1"
                     /translation="MNDITQLRQNVLEKAHQEGQQCLKIATDSLDTDFKERQQQGLHD
                     LKAKRQKELKALEQQFQVAQQQLKNQERQALLALKQDSIKELFEASLEKMTNFSKEEE
                     LAFLKQVLSKYPEQPLQVTFGEKTGQKFSSYDCAELRLAFPQLSYNQELIPQEAGFLV
                     SLDQVDDNYLYRYLLESVLKEESSRIIDMLFSEI"
     gene            complement(45406..45885)
                     /locus_tag="VHC05_000366"
     CDS             complement(45406..45885)
                     /locus_tag="VHC05_000366"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit K"
                     /protein_id="HEQ5401709.1"
                     /translation="MEHLAHYFTAHGGVFFAALGIVLAVALSGMGSAYGVGKGGQAAA
                     ALLKEEPEKFTSALILQLLPGSQGIYGFAIGILIWMKLTPELSVNQGLAYFLVSLPIA
                     IVGYFSAKHQGNVSVAGMQILAKRPKDFMKGVILAAMVETYAILAFVVSFILLNKIG"
     gene            complement(45887..47887)
                     /locus_tag="VHC05_000367"
     CDS             complement(45887..47887)
                     /locus_tag="VHC05_000367"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit I"
                     /protein_id="HEQ5401710.1"
                     /translation="MAISQMKKLAMVFEKDYLDLVLKTLQQSQLVEVRDMKQLKHWQD
                     AFNKGNVKLPQIVQYDLTHQKPLLDDEALQYLLQSQQELENGLASLSAFLPPIGKLTA
                     LRQKTPSLSFKQFEESHRQQAAQTALKMMSQKIERLEQLQNKIDQLTEYCQELEKWRS
                     LTVLPQDLAQFHFLSARVGTIPSTANDHFYHQLKQHKGLFIEEVYHTEFEYGLVLFWQ
                     AQDTIHLQKYQFKPLLYKEQLLPSEQLRINKELLTNWLAEKDSLLKELRQSQKILAQL
                     QVEIDYVLSQYQRQQTKKQLLGTRHLIALEGWIEADSVNQLKGLMTKTLGDMFYLDSY
                     DVTPDDWEDVPIKLRNHRYIAPFELVTEMYALPKYQEKDPTPFLAPLYLTFFGMMVAD
                     LGYGLLLYAVTLAALVFFNLQKTSKRLVTFFNILAISVAIWGLIYGSFFGFDLPVALL
                     STKTDVITILVVSLLFGFVTLIFGLLLGAWQQVRMKAYATAYTSSLAWTFILLGLLLF
                     ILGKNVSGLAYLSVIGKWLALGNAFGILVVSLLKSKSLLGLGSGLYNLYGISSYLSDL
                     VSFTRLMALGLSGASIGAAFNMIVGIFPPVTRFTVGIFIFILLHAINIFLSMLSGYVH
                     GARLIFVEFFGKFYEGGGKAFNPLKLADNYVNVNEETDLEDN"
     gene            complement(47877..48197)
                     /locus_tag="VHC05_000368"
     CDS             complement(47877..48197)
                     /locus_tag="VHC05_000368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401711.1"
                     /translation="MNTLLSLMNSIEQEARTIYDSYDAKKKALADKKEEELKQLFLEY
                     EQETQLLLEAKREVFFEANRQEQKASKKRLATQQLALHAILEEHKLTVVRELVDKVVE
                     TYGH"
     gene            complement(48651..49670)
                     /locus_tag="VHC05_000369"
     CDS             complement(48651..49670)
                     /locus_tag="VHC05_000369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HEQ5401712.1"
                     /translation="MDIIIGTSLLILVLAIFSLFNYKAPHGAKAMGALASAACASFLV
                     EAFQDSFFGKVLGFQFLSEVGGANGSLSGVAAAILVAIAIGVSPGYAVLIGLSVSGTG
                     IIPGFVAGYVVSFLIKWMEKNIPGGLDLISIIIVGAPLTRFLAQLITPVINSTLLTIG
                     DILTSSANSNPIIMGMILGGTIVVVATAPLSSMALTAMLGLTGIPMAIGALSVFGSSF
                     MNGVLFYRLKLGERKDNIAFAIEPLTQADVTSANPIPIYVTNFVGGAACGVLIALMKL
                     VNDTPGTATPIAGFAVMFAYNPVAKVLITALGCIIISLIVGYIGGSVFKNYRLVTKQE
                     LQARN"
     gene            complement(49707..50072)
                     /locus_tag="VHC05_000370"
     CDS             complement(49707..50072)
                     /locus_tag="VHC05_000370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HEQ5401713.1"
                     /translation="MKSYPEPMGPYSTYTIEGHFLYTAGQLPLNPVTGQLSDGFEAQC
                     RQVFVNLQSILAEQKLDLNHIYKLNVYLTDVTNVEILNHVMTDLFEEPYPVRTAVQVS
                     ALPLQALIEVEAVARVKQL"
     gene            50246..50926
                     /locus_tag="VHC05_000371"
     CDS             50246..50926
                     /locus_tag="VHC05_000371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEQ5401714.1"
                     /translation="MDKETLNYWKTVITFLHDVLGDNYEIILHVIDKNDIYIGELVNS
                     HISGRSKQSPLTTFALDLITNKVYKEKDFVTNYKAIVSPQHKEVRGSTFFIKDKKGNL
                     EGMLCINLDISAYQGVARDLLKLVNLNLEHFIPTAKEPKTVTPQPEEAVEILTSNIQD
                     IIGQIIDPSLLRHNVHLSQDVKIDIVAKLYEKGVFQLKGAVSKVADILCISEPSVYRY
                     LKKIEADQ"
     gene            complement(51048..51695)
                     /locus_tag="VHC05_000372"
     CDS             complement(51048..51695)
                     /locus_tag="VHC05_000372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacid CoA-transferase subunit B"
                     /protein_id="HEQ5401715.1"
                     /translation="MAVALSKEEIQNRIAKRVAKELEDGTLVNLGIGLPTKVANFVPE
                     EMTVYFQSENGFIGLGPKSDDPNSTIVNAGGQPVTVYPGAAFFNSADSFGIIRGGHVD
                     LTVLGALEIAENGDIANYLIPGKMVPGMGGAMDLLVGAKKVIVAMEHTNKGKHKLLKE
                     CTLPLTAKGVVDLIITEMGVFKVTPDGIQVIEISEGFTFDEVQAATGVPLSIAEG"
     gene            complement(51698..52357)
                     /locus_tag="VHC05_000373"
     CDS             complement(51698..52357)
                     /locus_tag="VHC05_000373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase subunit A"
                     /protein_id="HEQ5401716.1"
                     /translation="MKENKRIAIAEAISHIKDGDTIMVGGFMANGTPEALIDALVDKG
                     TKDLTLICNDAGFVDRGVGKMVANHQFKTIYATHIGLNKEAGRQMTAGETTIELIPQG
                     TFAEKIRIGAYGIGGFYTPTGVGTLVAEGKETKTIKGKTYLLEYPFEADVALIFANKA
                     DEMGNLQYSGSENNFNQLMAACAKTTIVQAREIVPVGTIQPECVHTPHIFVDYIVKEG
                     V"
     gene            complement(52369..53553)
                     /locus_tag="VHC05_000374"
     CDS             complement(52369..53553)
                     /locus_tag="VHC05_000374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="HEQ5401717.1"
                     /translation="MTKEVVITSAYRTPIGNFGGVFKSLSAVDLGVTVVTKILADTGL
                     KSDAIDEVIFGNVLHAGLGQNVARQVALNAGLSYDTPAFTIDMVCGSGLKAVELGAQK
                     IQTGNADIVLVGGTENMSQAPYVLQGQRWGSRMGDSKVVDTMLKDGLSDAFAGYHMGI
                     TAENIVQQYGLTREEQDAFAADSQRKAQLAIEKGRFKEEIAPVTIPQRKGEPLLVDQD
                     EYPKFGTTVDKLAKLRPAFIKDEGTVTAGNASGINDGAAAILLMSKEKAEELGLPILA
                     KITSYASAGVDPSIMGCGPIPATKKALAKAQLTIDDIDLIEANEAFAAQALAVSRDLG
                     FDNEKVNVNGGAIALGHPIGASGARILVTLLAEMAKRDVRHGLATLCIGGGQGQSIIV
                     TR"
     gene            53674..54585
                     /locus_tag="VHC05_000375"
     CDS             53674..54585
                     /locus_tag="VHC05_000375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEQ5401718.1"
                     /translation="MNISSLAYFIEIVNCDFNLTKAAQKSHISQPALSSYIKTIEKEE
                     GVVLFQRQKGRLVGLTSVGERFFENAKVVIASHEQLMADLRSESKKYKGEISIGIPQL
                     ISGIVFSELIPKLIEENPEVKFHIVETGAYELQKKLFLKEVDFAILLTPTTLDATIAD
                     IDILLRDQLCLYMSHKTFQETFDSNPNISIKALHRQNLVTFDKTFMINHQLTTLFEEA
                     NSLPVVKCYSASWDFLLNCTRYSSYLTILPRPITHFAHMDGLVEVQLTEHPKWEVVLA
                     SLKHNKTSHLKHYIKHTILDYFTNQRF"
     gene            complement(54653..56059)
                     /locus_tag="VHC05_000376"
     CDS             complement(54653..56059)
                     /locus_tag="VHC05_000376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="short-chain fatty acid transporter"
                     /protein_id="HEQ5401719.1"
                     /translation="MNNIKTKKRFMDRYIDGFMKWMPESLFICFILTFLVVTMSVLMT
                     DSPFIGTEKTGGIIYGWVNGFWGLLSFAMQMTILLATGNAVASSPPAHKMFKSLAKLP
                     QTRTQIFIFSLVVGSIFGFLHWGLGMMVAIVFGKELLVQARQKGIKVHTPLFVATLFF
                     TFLPATSGLSGAAVLYSATPDYLRNSVADAYKQVVPESVPLTESVLNLPFISLLVVCM
                     LVPLCFTLLAHPKDETKIMELDDEIYHHSLDTASHVVIARNTPAEKMNASRLVMYLVG
                     GAIVSYSLYHFSVVGLSGLDLNSFNFLFLGLGLLLCGQQGPEYYGSLFKDGVMSSWGL
                     VLQFPFYAGIFGIIQSTGLGLEISHFFVAISNGTTWPVFAYLYSALLNIAVPSGGSKF
                     VIEAPYIVPATIEVGNDLGKILQAYQLGDATTNLIVPFWALSYLSNFKLKFNQIVAYT
                     IPCVLVVTGIAIIYLFVF"
BASE COUNT        16964 a        12141 c        10230 g        16952 t
ORIGIN      
        1 taggtcaaca taatgatttt aaaaattcca ttactattaa tcttataaca aagaagctca
       61 ataattttaa tttaggacaa aactagctat atcaatacaa taatttatta gcttataaga
      121 gctcaataaa aaataaaccg aactcatcac atcaagttct ttgctcattt aaaatgcaca
      181 aaaaaagagc acacacccga aaatcgctta gggctgctgg attcctcccc tgacccactt
      241 cacgcacaag tgttgctccg cctattatta tatcatatta cggacagttt gcaagttttc
      301 caactaagta aaatcacttt caagtgagaa tagcttcatt ttgggacaag atggactgaa
      361 tacctagaaa aatcatgacc ctttccaaac acgattttgc tttttgaaaa tctttccctc
      421 tccccattcc agctattctc tatgttataa taagattatt agattagaat gggagttatg
      481 atgaaacaaa agattaaaat cttaacagta attggcctta tgacagttgg tatgtctgcg
      541 tgtcacaaca ctagcaaacc ttctaatacc gattctgttt tttctttaac cggaaaaaag
      601 cgccaacaaa tcgtcaaaca agtaagacaa cggtattatt tccaacaatt atccaaaacc
      661 gaacaagaaa attacctcac tttatacgat agtctagcac aatttcgtga aatcatcagt
      721 ttgacgccgg cttctaaaaa aagcttaatt aaaacgattg acgcctttgt gatggataat
      781 cccgaatttt actggattac atctgccgat tatcgatttg agttttctga tcaaacggtc
      841 tttgtcacct ttcctatccc agaagatgcc aagaacgttt atcaagactt gcaagcaatt
      901 ggtaatgaca tcgtcgcaaa cacgccatca aaggatcgct atgagcaggt caaatatttt
      961 tatgaggtca tcattcgaga cacagactac aataaaaaag cctttgaagc ctatcaatca
     1021 ggcagtcaag cccaggtcgc ttctaatcaa gacattaaaa gtgtttttat tgatcattta
     1081 tctgtttgta atggctatgc ccaagccttt cagtttcttt gtcaaaaagc tggcattcca
     1141 gtcgcctata tccgtggaac tggtacatct cagcaacctc agcaatcttt tgcacatgca
     1201 tggaatgctg ttcaaattaa taacacttat tatggcgttg atgtcacttg gggtgatcct
     1261 gtttttgata accatctctc acatcaaaag caaggaacta tcaattacag ttttctatgc
     1321 ctaccagatt atctaatggc cttatcacat cagccaagca aagacattgc ttttaatact
     1381 aaagaacgtt ttgaaaatgt ttggactata ccttcttgta cagatgattc tttgctttat
     1441 tctaaacgtc atcaaagcta tatctcaacg tttgacagtg acgccatcct tgcaagcctt
     1501 gaaaatcagt tgttaaatag acaagagcaa ctatctctac aatttgctca tcaagatgat
     1561 tatcaacaga tggtaactga tttaacgacg aatcaaacag gttatcataa ccttttcaac
     1621 cagtattgga ataattatac gggctttacc tatggactct taccagagac tcttagtatt
     1681 tcatttgcta gtaggaacta ggtttagaca catgaaacac aaagttaaga tgattatctt
     1741 tgtcaaacat tacaagaaat tgatatacta acacaattga aggcgattat tattctaacc
     1801 gtcttcaata gatataacct tttcagattg agcacatcta atgcttgtaa cattagcaac
     1861 agtgatgagc tcttttttaa tgctttagca aaatatatca gctaagacaa aagattaaat
     1921 aactcaagcc atgcctataa gtcacttgtt tttaatccct gtgtcagtgt caatctacgc
     1981 cacagataac tgacagctct gagccctaga agtctgaact tgataagttt actaaaaaca
     2041 aaaataaggt gagccattac tatctgtttt tagatagtaa atctttttaa gaatgactaa
     2101 ctcatctagt catcacgtgt ttgatttttc gattgttttc acctcgattg ggtctgaaaa
     2161 agagcgtttc tagtacttgg aaacgccctt ttgtatattc tatcttcgta tgttgaatct
     2221 aacaaccatt ggaaaaatgg tctaacgttt cactcattat tttgacaggt tacccttcac
     2281 caaaaatgca tgtgataaca agctccttaa aactctaatc aaagggatct gactgttcct
     2341 tgatcaaatg cttagctatt tttttgcgct ctcgcccttg gcggaaaaag gtttgcatga
     2401 tgttagcaca gtctgctgct agcaggcctc gttcaacttg cacgcggtgg tttaagcgct
     2461 catctgtcaa aatctggtaa aggctgtctg ctccaccaaa tttttgattg ctggctccat
     2521 aaataacatg cggaatcctt gctagcccaa tagcaccact acacatcaca caaggctcga
     2581 tggtcacaaa gagtgtggtg tctaataaac gccagttgcc ttcatgagcg ttagcctcgt
     2641 taatggccat catttcagcg tgcataatgg cttggttact ctcttcacgc gcattgtgcc
     2701 cacgaccaat aatctcacca tccttgacaa tgacacagcc aatggggatt tcagctttct
     2761 gtaaggattt ttcggcttct tttaaagcct cttgcatgaa ataagtttgc tcttctaaac
     2821 tatatggcat caagaaagac tccccaagtt ccaagatttg tgtggtaagg caaggtcaac
     2881 aggaatatta cctgcatagg cctgtgtttc ttgcctcaac acttctaaat ggtttttgga
     2941 attaatacct tctggaggaa ccggtggcat gtgggtcaag acaagcttct taacacctgc
     3001 ctggctagcc attagtcctg cttccttact ggtcaaatgg gccatatgat tttcattgcc
     3061 ttcgtataag taaacatccg ctaagaaaag gtctgcttct tttgcgaagt ctgccaatcc
     3121 ttcaaaataa ccactgtctc cagtaaagac aagtacctga ccagtcgctc tttctacaat
     3181 tcgaaaggca taacacacaa ctggatgaac tgttttaaga aaggtaatgt caaaaggacc
     3241 aatctgttca actccagtaa catcataggc tctaccttct gaaacatcag gaatgcttaa
     3301 cttagcaaat tcgtgtcggt cctcatcatg cccataaatg ggcaatactt taggctgcca
     3361 caggtgttta ggataaagtt gaaaataatg gcgcaacacg cctaaatcgg ccacgtggtc
     3421 tggatggtaa tggctaataa tcactgcatc caaatcgaga ggactgattt ctttttccag
     3481 ctcattgagc gctcgactac cagcatccat caataactga aagccgtcat gtcctgtgac
     3541 caaataagag gttgtgcctg catcttgata gggataggct ccccaagacc ctaaggtggt
     3601 taatttcatc tcaaaccctt ctttcttgct ttaactctta ttataacaaa aattagtgtc
     3661 aaagaggatt gagacccacc aaaaacaggt cctagcagat aaatctgcca agacctgttc
     3721 aacacaactt aactatttga tgattagatt actgttttgt attcaaaaaa ctatctttgt
     3781 atttaacagc gataatggtc gcaatgattg ctttgatggt atctcctgga ataaagacca
     3841 agtttgataa cagagaagtc atcaacggca tccctgtgta agctgccaac caaatcgctc
     3901 ccatcacatc cactagcaag acaccagaaa tgaataaggc taagaaagca agtggcgtgc
     3961 tttttgagaa ccagttgcgg taaagtaatg aaaagacaat aggcacaaga aggtaggcaa
     4021 taacatagcc agcagatggc cccatcaata ctggaatggt tgttcttgag cctgagaaaa
     4081 caggtaagaa aaggccaatc actaaaaata agaaaacaga taaggttccc tttttaccac
     4141 ccagcatcaa tccagccaac atgacaccta agttttgtaa aacaatagga actgggataa
     4201 agcctagcgg gatagcagga ataaagccta aaataataat caaagtggtc atcatagcca
     4261 ccttaacaag ttctttggtt gtaaacatct gttacgactc ctttaaaaaa tagatatcct
     4321 tgtgcctatg acaggctgga ttaaagggac tttgacaata aggacagcat ccacaaccat
     4381 actcagctag gctcaagagc tttcgacaat gcccacaaat aacaggagat gtttcttgat
     4441 gtcctgttgg cacaaaggca tgatctgcta actggtcatg acaatggtag caagcataat
     4501 aagtctgaca aaaagcacat ttgagcccaa caatatcaag cggggtatga taatgtaggc
     4561 accgatactc ttggtcaagg tcaattccaa aacagtccgt catatctcat cctcttgtaa
     4621 tagtttaatc aaaagcttat agtttgtcaa ctctattttt aaaaaagggt aactgttttc
     4681 tgaaaaagaa cacgtaaaac aagaactttc ctttaaaaag tgacctatca gttgaaagca
     4741 ataggacatc cgtctataca aaaaaactga aaccaaagac gatagatcgc cctcagttcc
     4801 aggatcatag catttttaat tagaaattac ggtttgattt attataacca taccgttcaa
     4861 gaaaatcttg gcggaattca agtaagttat cgtccataat agcctgacgt acttttttca
     4921 tcaagttaac caagaaataa aggttgtggt agcttgtcaa acgaatacca aaagtttcgt
     4981 ccgcttttag caagtgacga atgtaggcac ggctatagtt ttgacaagtg tagcagtcac
     5041 agtcatgatc aagtggggta aaatcttcag cgaatttggc atttttaacc acaagacgcc
     5101 cctcactagt catgcaggtc ccattacgag cgatacgcgt tggcaagaca cagtcaaaca
     5161 tatcgacacc acgaatcaca ccatcaatca agctatctgg tgctcccact cccatcaggt
     5221 aacgaggttt attttctggt aagaggggag tcgtaaagtc aaggacggca ttcatttctt
     5281 catggctctc cccaacagct aaaccaccaa tagaataacc tgggaaatcc atagccacca
     5341 aatctgccgc agactgacga cgaaggtcct caaatccagc tccttgcaca attccaaata
     5401 atccttggtc atgaggacga cgatgggctt ttaagccacg ttctgcccaa cggctagtac
     5461 gttcaatgga ttttttcacg taatcataag gttggtaaaa ttgcgggcac tcgtcaaaac
     5521 tcatcatgat gtctgagcca aggttattct gaatggaaat ggctttttcg ggtgatagaa
     5581 acatttttga gccattcaag tgatttttga aagtcactcc ttcttcagtg atgtttcgtg
     5641 aatcggctaa agagtaaact tgaaaaccac ccgaatcggt taagattggc tgatcccagt
     5701 tcataaactt gtgcagacca ccagagcgag caatcaactc atctcctgga cgcaaccaga
     5761 ggtgataagt gtttgataaa ataatccctg atccaattgc ttttaactct tctggagact
     5821 gtgttttaac agtagcctga gttcccactg gcataaacat tggtgtcgga aaggtcccgt
     5881 gaggggtgat aatttcgccc aagcgtgcac cggtgtgctt ttctgttttg ataaggcgat
     5941 acttaatcgg ataatctgtc atgtgctttc ttccttgcta tcaagataaa cagtcttgag
     6001 cttttttgat ctgcctgagt ttccatcata atgaagggct tcaagatgac atgttgttct
     6061 agcgcctatc attttatcaa aaaatccata atttgtcatg ctttcccaaa aaagtatagt
     6121 caaaataatg gttagctgtc tcattttgtt ttatggtata atgaaataaa ggagtctgtt
     6181 atgtcaatta aagcaatcaa aagccaggct agagacacgt taaaaaatct ctctggcaag
     6241 tatttactat ttttaattcc aacccttctc tttatgtttc atttcggtat tgagattcat
     6301 caaggttacg tcctatctag tggtattgaa gtctcgctag cggctagtta tttcccatta
     6361 ctactaggac ttatccttag ccttttcatt ttatcagcat cctttacgat gattgatgtt
     6421 gttaggcatt ttcgtcagaa agtttctttt gccgaatcaa caacagcctt ctcaaaagaa
     6481 ttctttggga acctgctggt tttagcgatc actaagtggc tattctttct catctggtca
     6541 ctaatttggt tttttggcct ctttattttc ctttccggac tttcagcgtt tttggtcaat
     6601 gctaaatcag gtagctcaac agtcatttca ctgatctttt tactatttgg agcagttttg
     6661 tccttaattg gttttggtat ttatatcaac cgttattacg cttatagtct atcagaatac
     6721 cttctctacg ataaggttaa agaggggact tatctaggag ctatagccgt tattaaaaca
     6781 agtgtagcta tgatgaaagg ttataaatgg aagctttttt tcttacaact tagcttcacc
     6841 ggttggtttc tactgaatat tgttactttt gggttactta atatctatct tttaccatat
     6901 tttacaacag ccaatgtcat tttttatgat caactcaaga aacgtttcaa agacaaagat
     6961 gacccaattg aaggagaaca tttaagcctt catcagctta ataaaaagcc tactcctatg
     7021 atgtatgacg atcaaaaaga ctaaataaat cctccgtcca taaaaatagc cctcagccaa
     7081 aatgaactgg gggtttttga tttgtaaagg cactatattt ataatgcttt atttaagggt
     7141 taactctaaa aatcaggttg gtcttttgct tggcaatccg gacaaatccc gtaagcaata
     7201 actgggatac gcgtgacctt ataacctgtt tgctcatggg cttctttggc aatatccata
     7261 acatcaacat ccataaagtc agcaatcttc ccacatattt cacaaaccac attgacgtgt
     7321 tgatggccca taaagtcata gtaggtggtt aaatcattgc tgattttcaa ttctgagaca
     7381 aaaccttcat caactaaaac tttcaaatta ttatagactg tggcaaggct catgttagga
     7441 aagttaggct gtaagtcacg gtaaatttta tcggcactag ggtgttctgt ggactgaatc
     7501 atgtaagaaa taatggcttt acgtgtctct gtaattcgaa tatgtttttc ccgtagatgc
     7561 tctaggacat tttcataggc atctagggct tgctgatgtg aatgaatgtc cataagctgc
     7621 tactcctatc cttttttcct ttattatcac gcacgtctct agtttcaatg attcgtgatg
     7681 cattctggtt tagcgactaa ttgcaaatag tctattttta gacagcgatt catcacaata
     7741 gcctctttgc ctgccgaccg taaaatggtt tgtgcttctt ggttttcaag gcctaattgc
     7801 gcccaaaaga ctttggcctg acctgctaaa aagtctctgg caacttctgg taaaaactca
     7861 cttctgcgaa agacatctac aatgtcaacc tcaaagggaa ttgccttgat actggcatag
     7921 accttctctc ccaaaataag ctgacctgct aatttgggat tgactggaat gatccgataa
     7981 tccatagcct gcataaattt ggcgacacca taagctgctg tgtctttgcg gtcagaaaga
     8041 ccaacaaccg caatggtttt ggctgactcc aagtaagctt ttaggacagc ctctgaggga
     8101 ttttgaaacg aataaatcac ttgttcccct atctatttaa taacctctac agctgttcaa
     8161 tatagcagga taactcctaa agcatggctt caatcacttt taaccttatc cgtcaaaaag
     8221 ctcaaagcag cttcatgact tctcctacaa ttttttagtt tattataaca taagttgtca
     8281 aaatgagaaa taacaagtaa gaaaacttat ttggcttcgt accagctctg cccagtactt
     8341 tcatcgacac ataaaggaac agctaaatca acagcagctt ccatggtgtc tttgacaagt
     8401 ttttttatag cagtcaactc atcatttggc acttccaaaa cgatttcatc atgcacttga
     8461 agcagcattt tagctctaaa accacctgct tgcaaggcct tatccagatt aatcatagcg
     8521 attttgagaa tatcagctgc gcttccttga atgggcgagt tgatggctgt acgctccgca
     8581 aaagagcgaa cgttgaaatt acgagagttg atatccggta attcacgacg acgcttaaag
     8641 agggtctcta catagccctt gtctttagcc tcacgcacca cattttccat ataggcttta
     8701 atcccaggat agcgttcaaa ataggtatca atgtaagact tggcctgttt acgggtgata
     8761 ccaaggttat ttgacaaacc aaaatcagaa atcccataca caattccaaa gttaacagcc
     8821 ttggcattac ggcggtcatt ggcagtaaca tctgctgcct tgtcaatccc aaacacacgc
     8881 atagccgttg aggtatgaat gtctgcccct tcattaaagg cagcaatcaa atgcttatcc
     8941 cctgaaatat gtgccagtac ccgcaattca atctgtgagt aatctgaact caacaagacg
     9001 gcatcttcat gagatggggt aaaggcctta cgaatcaaac gcccctgttc caaacgaatg
     9061 ggaatgtttt gaagattagg gtccacacta gacaaacgcc ctgtctgggt gagatcctgc
     9121 acatagcggg tatgaatctt gccatcagcc agaatataat cctgtaaacc aatcacataa
     9181 gtggattgca atttagtaat ctggcggtaa tccaaaattt tagccacaat tggagcaatc
     9241 ggtgccaaac gttccaaaac atcaacagct gtagaataac ctgttttggt cttcttagtc
     9301 atctcaagag gtagttgcat cttctcaaac aagatactgc ctaactgttt aggcgaattg
     9361 atattaaatt cttgaccagc catatcgtaa atctcttggg tgagcgcttc aataatgacc
     9421 ttgttttgct ctgccatatc ttgcaaagtc gtcctattaa ccttgatccc ttcaatttcc
     9481 attttagcaa ggacattagc caaaggcaat tcaatattct gatagaggtc tagttgctca
     9541 tgggcagtga gcttgtctag catttgagac ttgctatcta ataatacttt gaccttacga
     9601 gctaagtgtt ctagtaagac gtctttatca ggaacagccc gtttagcacc tttaccatag
     9661 accgtatcgt cttcttccaa agagatgtca gtaaaaatgc gggcaatggt gctaagctca
     9721 ttgtcttcta cagttgacag aaggtaatta gctagtctag catcatagct aggtgctacc
     9781 aactcaattc ctaagtggct caacaagacc ttgctacgtt taaaatcata agtggcaatg
     9841 ggtttttgga agacctgctt aaaactatcc gtcgctaata ggctaaggtc tgtggatgcg
     9901 taaatctgct caccatgtcc ccaagcaaaa ccaatgatgg cctcacgatg gtaattatcc
     9961 cgaagcgttt caaagtagaa gatgtcttct gcgctaaaca aatcagcaga cacattggtc
    10021 acttcttgat aggaaatgac agctactggc tcttgaggca tctggctagc aagacctttc
    10081 ttgagttgca caaaatccat ctcatcgtaa aattgagaga ggctagcaac atctggacca
    10141 ttgtagacaa tatcatctaa gccaattgtg ataggagatg ctgtattgat agtggcgagc
    10201 gttttagata ggaaagcttg gtcacggtca ttgatcaagt tttctttcat ttttgaggtc
    10261 ttgaatccat caatatgctc gtaaatgcct tccaaactac caaattcatg aaggagctta
    10321 aggcctgttt tttctccaat ttttgtcact ccaggaatgt tatccgattt atctcccatc
    10381 aaggctttga ggtcaataaa ctggtttggc gtcaagccca ttttttccat gaggtaagcc
    10441 gctgtgaatt cttcaaattc ggcaacccct tttttagaaa tttcaaccac ggtattttcg
    10501 tcagttaact ggatcaaatc tttatcacca ctgacaatgg tcacatcaaa aggcacttcc
    10561 gtgcgctccg ccattttatc aagcgtcccg ataatatcgt ctgcttcgta gtgttccaac
    10621 tcataataag caatcccaag ggctgtcaac atctcacgaa tataaggaaa ctgctcacga
    10681 aattcctctg gtgtcttggc gcgacccgcc ttataatcgg catacatttc tgttcggaag
    10741 gtggttttgc ccgcatcaaa agccaccagc acgtgagtag gctggactct tttcatcatg
    10801 tggtctagca tcaaatgaaa gccataaatg gcattggtat gaagaccgct atgattttta
    10861 aagcggtcaa tttgattgta aagggcaaaa aaggcacgaa aggcaacaga ggagccatca
    10921 attaatagta atttattctt gttttccata agcttattat aacacagagg gacgggcttt
    10981 tctcctttaa gccattggtt ttgctgataa gtaaatggtt aacctaaaaa gcctaggaaa
    11041 attcctagac ttctctattt gctatttaga caaaagcact tattttgtcc aacttgatac
    11101 tttagatttg tttgcctcta cccatttttt ggcggcagct tctggactca tgcctttatt
    11161 gatgtcaagc atgactgctt ccatatcttt ttgggtccag tggaacttat caatgatttt
    11221 gtagacattt ggaaggtctt ttttcaagcc tttacgagca atggtattga tgttctcagt
    11281 agagccaaag gtttctttag gatctttaag gtacttcaag tcatacttgg caaacatcca
    11341 gtgtggtgac caagctgtca cgacaatagg atcttttttc ttgatcgctt gatccaagga
    11401 tgttgtcatg gctcctgttg atgccgccac taactcccaa ctagatagat tatgatactc
    11461 ttttagagtc tttttggctg ctgccataat acctgcacct ggttcgatcc ctgtgatttt
    11521 ttgatcggct tgtttgctta aatcctcaat actattaaca tctgtcatgt atttaggaac
    11581 agctaaccca agtttggtcc cttttaggtt aggccctaaa tcatctaatt ttgacttgta
    11641 tttctgatat tgttggccat gggtgactgg caaccaagca ctagttgaaa aatcagcgtt
    11701 cccatttgca acggtttgcc acataacggc attgtcaagc ggagtcaagg tcacatggta
    11761 accttcgttt ttcaaaactt ctgcaatcac atgagttgag gcaacctcag aatcccactg
    11821 cacgtaagcg atgttaacag tttcaccctt atctgccata ccagaagtca tagccataat
    11881 accgcgtcct aaagcagcta tcaaaaagac agcaagggct gctagaccaa tccatttatt
    11941 ggttttgcca gctttggctt tttcttgagg tttgctattg aacaactgtg tcatacggtc
    12001 aagcacaatc gccaagataa ccaaggcaag accactgaca aatccactac caatatcagc
    12061 gtgttgaagg gctgacaaga cttcacgtcc taagccagga gcaccaatca tggagcctgt
    12121 tactaccatg gaaagggcta acatcatggt ctgattaaca cctgccataa tagtattttt
    12181 agctaaaggc aattccactt taaagagctt ttgtttccca gttgacccaa aggcatctga
    12241 ggcctcaatc aattctgttg gaatgtcacg aatggccaaa tttgtaaaac gaaccgttgg
    12301 aggcaaggca aagatgactg aggcaaacac tccaggcacc ataccaatac caaaaaaggc
    12361 aacggcagga atcaagtaaa caaaagccgg catggtttgc ataaagtcca aaataggatt
    12421 cacaatctga cggacagtgg catttttagc catccaaatc cccagcggaa taccaataag
    12481 taccgaaatc aaactagcta ctaacaccag agtaaaggta ttcattagct gcttccataa
    12541 cccttgattg taaataaaga gcaatcctaa caaggtaaag gttggcaaag gccatttttt
    12601 cttagcaagg aaaaacatcc ctgctgttac tagaacaata aaaagtaacg ggtggataaa
    12661 taaaagtgtt ttggtcatcc aatccatcaa aaagctacca actacttgca taatatcaaa
    12721 tagacctgag aaagttttag ttagccactc cgttagctgc tccaccagtt gagctactgg
    12781 taattttgtt tgtaatatcg tttccaaaat gcatcactcc ttttagttaa ggtcttcgtc
    12841 tgagatatta gccaaggctt caatcactcg tcctcgaata atgacaccta gcagacgatt
    12901 attatcatct gtcactgcaa tcggagcaga tgaatcatag ataagaggca aaatatctgt
    12961 aataatagta tcttttgaga cagttctcac atcgcgatca atcacttctg atagcggtaa
    13021 cccttttttg cgcgcctcta tagcggcatc ggccgtcaaa ctaccgacta attggcggcg
    13081 gcgattcgtc gccatcaaca tagacacctc ttcgttgtgc atacggttca aggcaacttg
    13141 aggtccatct aattcaacag tagttgttaa cggtttgatc atgatatttt gtgctgtcaa
    13201 gactttagaa cggtccacat cctcaacgaa ttcacgcaca aagtcattgg ctgggttagt
    13261 caagatttcc tcaccagtac caatttgcat aatttgtccg tctttcatca aagcaatccg
    13321 atcaccaata cgcaaagctt cattcaggtc atgactgata aagatgatgg tttgtttcat
    13381 gctatcttgc aaatcaagta attcatcttg catctcacga cgaatcaaag gatcaagcgc
    13441 tgagaatgcc tcgtccatta agagaatttt agggctatta gctagcgcac gggctaggcc
    13501 gacacgctgc tgcatcccac cagatagttg gtttgggtac tggtctttaa aatctaatag
    13561 gcctgaatta tcaagggctt tttctgccaa tcgctggcgt tcttctttgg gaacgccacg
    13621 taattccaaa ccaaattcgg tatttttcaa aatggtttta tgaggaaaga gggcaaagct
    13681 ttggaaaacc atgttaatgt catggcggcg cacctcacgc aactgatctg ctgacatggt
    13741 tgagatgtct ttaccttcca gcaagataga tcctgctgaa ggttcaatca aacgatttag
    13801 catgcggaca agggttgatt tcccacttcc tgatagcccc ataataacaa agatttcacc
    13861 ttttttgacc tcaaaactag cgtcatagac acctacagta gcgcctgttt tcttaaaaat
    13921 ctcactctta tttttgccag tctttaccat ctcaagagct gctttttgtt ttttgccaaa
    13981 aattttactg agatgtttga cttctaaaat tgtttccatt cgttttttct cctaggtaat
    14041 cgtttatcat gtgaaatagt gacatagctt tggcgaaata ttagccaata tttaacaaag
    14101 tagctctaca caattaataa acgtgtggtc acttttttac ttaaaaaaag aatctgccga
    14161 aacagaacat aactatatta tcacgtgtgg tcactttttg tcaaggacaa taactcgatc
    14221 tgataatacc acaatgatag gtgatcgctt tcattctttt aggtatggtc ttttaaccag
    14281 tacaattttt tatcacaact gatgactatt tctttgctga ttaggctatt gttacattag
    14341 aaatccttct tttacctgta atatctcttt tgcggccatc gtaaataacg accacggtga
    14401 ctcttaaaca tttgctcatc tctccaaaaa aactcaccta agacagtgtc ctatgaagcg
    14461 agttagctta atcaggcact atcatcttag gtgagtaggg tgttgcttat agtaaagctt
    14521 taaattggat attagaatct tctaagaagc agtcatcaaa tccacgagga tgatggtatt
    14581 cgatacgatt ttggtcttgt ggataggtgt acttgccacc aacctcccag ataaagggat
    14641 ggaaatcata ttggagacgt tctttgcgca ttttccacag ttcaaggatt tcatctgttg
    14701 atgccataaa gtttgaccaa atgtcataat gaactgggat aacgacttta gcacggagat
    14761 tttctgccat acgaagaagg tcaacagaag tcatcttgtc ttgaatccca attgggtttt
    14821 ccccatagtt atttaacaca acgtcaatat cataatcacg tccatgttta gcaaagtagt
    14881 tcgaaaaatg agaatccgca ccgtgataga tggtaccacc tggtgtttca aaaatatagt
    14941 taacagcttt gcgagccatg tcatcatctg tgatagctaa acctgctaaa tcaccatctt
    15001 gagcatcagc tccttgtatt gggagagtta ccagacaggt gcggtcaaac gactctacgg
    15061 cggtgatctt aatatctttg aattcaaagc tatcacctgg ctttaagatc ataatacgat
    15121 cttttggcac accccaattt ttccaaactt caccacattc atagggacct acaaatttaa
    15181 cgtggtcaag ttttgggtta ttaataatgg ctgccgcagt attgatatcg atgtggtcac
    15241 tatgataatg agaaaccaaa taataatcca actcattaat cataaatgga tcaatcacca
    15301 ttggttgggc cctaagattg ggctgtaatt tacgagctcc tgccatatta gccatttgat
    15361 gtccacgaac catatcctta acttgcttgg tcgctttccc acgatttgac cataagtcca
    15421 tgacaacatt agcaccgcct ggtgtcttaa tccagatacc acagtttcct aaccaccaca
    15481 tcgcaaagtt gtcagctggc acgacttctt gctcgatttc ttcatttaac catgttcccc
    15541 attctggaaa cgtgttaagg atccatgatt cacgtgtaat atcttgtact ttagtcatta
    15601 gggtttcctc cgaatttgtt cttcgtttct atactttaag tatagacttt cttgtcaatg
    15661 ataaaaagac caagtgtcac acagatctgt gttcaaaagt ggactgactt tttcattagc
    15721 tcagtctaat actgtctcat tttgcacact gtatctcgca tcaatactgt attcaaagct
    15781 atattaaaaa cctcagttat atttttctat gtcatagaaa actgaggtac tttgacgact
    15841 taacactcac tcatagcagc tcgcgatgaa tgagtttttc aattttagaa accaaggcat
    15901 aacgatctga ttcatctttt acaacagctt caatagcttt tgtgagctct gtagaaaagc
    15961 gggaatgctc actcaagcgt ccttgctttg aaaagcgtat caatttgatg atatcatcgt
    16021 cacttaaaat agggttaaca ataagcatcg ggattttagt ctttagcgta tctgtagtag
    16081 caacaatcat atcgactgct aaaagatcgt aaacactctg atactgttct gtcgtaaaaa
    16141 cagcttcaat ctgaccattt gctagatacc tttgacactg tttgaacaat aacttttgaa
    16201 tgcctatccc atcatctgaa acaataacga gtttggtctt ttcttgctct gtattattgt
    16261 gacgcagctc tcccccgaga tggatagtca agtaggcaat atcatcgtct gtcaagctaa
    16321 tcgtccaatc ttgttccaaa atagtggcac aagattgagt catagcaaac aattcttcgt
    16381 atttttcttt aatatggtct gttaagggat taactaaaaa aatcccataa gctttacggt
    16441 aaacgagcgc cttacagtgg gtcgtcaact gcttcagcaa atcctgttta tgcgtgaaat
    16501 gtaactgata acggctctcc aactggtcaa taaagtgact aatggttgct cgcatgtcat
    16561 cataatcttg actttccacg tgatgatctt gatcttttcg aaaagacaac atcaacatcg
    16621 ctaccatact aacttcgata tcatccaaat gaagcttaaa attatggtaa agctctctag
    16681 ctaagtcctg agcaatgtga tattctttac gtttccaaat caaatgaaat tcttgtttaa
    16741 gagcagactt tgtttctgaa tcaagacgca tattacgata acttaaaagc atgaaaggta
    16801 aaatctgcaa catgaattgg ctatcttggg tattaattgt ctttcctaaa ctagcttgag
    16861 ataaaaaaag atactcatga aaataagtca aaatatcttt agaaaaataa accgataagc
    16921 cttgtatctc tgagagttta cggttgaata tatcaataaa gctagtattg ccaccttggt
    16981 aaacgtccac taacaatttg tacaggtatt gaataagagc cattggatga caaccaaaat
    17041 aatatcccct agcctttgtc gcatgaagct gaatcttgta ttgtttgtct tccagttctt
    17101 cccttaactc agtcaggtca tttaaaatcg tgttacgaga cacatcattg atctgcatca
    17161 gtttatcaat ggtcacgcgc tcagtggaaa ccgcaatata aatcgaggat aggcgtctgc
    17221 gctcatcact tttcatgaca taattataat cagtcacttc ttctaataat aagcgacaag
    17281 cagctttttg atcagctgtt aaaagaatgc caagtctagg ataagagata atctgatcta
    17341 ctccctttgg caaagcctta ttaattttgt caagctggta ataaacttta cgacgtgact
    17401 gatttaaagc atgagaaatg gccataactg tctcaggtgt ttctagttta agtaaataag
    17461 acagcaagtc ataactcttt ttatctaaaa tcatcatgat tacaaacctc ctctctgaaa
    17521 atccatcctt gcttatttta tcatgatttc agtgactgcg cagccaagtt ttgaaaaact
    17581 caccataata agattcgctt aatatgattc gagctaatca cctcaactga tccaacacca
    17641 acaccttata tctggtctct aagaactcca caacatacga ttcatcaagt ttgtgctcat
    17701 tggcgtttaa acagttcatc gaaaaggaca agtcaaaagg acttgcccaa acaatgatta
    17761 acaaaacctt gaactttctg gcttctagtg agaacctgtg ctaataagcc atatcgtgac
    17821 ctcatttttg accgtaataa gcatttgggc catgtttacg caaataatgc ttatccataa
    17881 tgtatcgtgg cgctggctct acgcgtggat tgatttgttc tgtcaagcga ttcattttag
    17941 ccacttcttc taagacaacc gagtggtaaa cggcttgctc tggggttttc ccccacgtaa
    18001 atgggccatg attgcgaacc acgattcctg gaaccgccat aggatctaag cctcgcttgc
    18061 taaactcttc taaaatcacg ttgccagttt cttgctcgta agccccatca acttctgctt
    18121 ttgtgagaga acgagcacac ggaactggtc catagaagta gtcagcatgc gtagtcccat
    18181 aaaacggaat atcacgacct gcctgagccc aaccaacagc ttctgtggag tgagtgtgga
    18241 caataccgcc cacttctggc caagctttat aaagttccac atgggttggc agatctgaag
    18301 aagggttcaa atcaccttcg accacattcc catcaaggtc tgtaacaacc atgttttctg
    18361 gtgtcaagag gtcgtagtcc accccagaag gcttgatgac aatacgtcct aattcacgac
    18421 aaacttcaga gacattgccc cacgtaaatt tgacaagacc gtgttgtggt agagacttgt
    18481 tagccgcaca gacacgttca cgcatttctt gcaagttttt cgccatatta tgccaacccc
    18541 gctttctcaa taagtgggta aaggaagtcc tgagcttctt tgatagcagc ttttgtttcc
    18601 tccaccgtgt cacaattttc tgaccacatt tcaatcaaaa aaggcccatt gtagttggtt
    18661 ttcttgagga ccgcaaacag ctcttgccag tccacacaac cttgaccaaa tggcacatca
    18721 cggaactgcc cttttgaggt ttccgtgaca gcataagtat ctttcaagtg gagagctgca
    18781 atggacttgt gaccattgta aaattcactc cacaaatcat tatgccaggc agaaacattg
    18841 cctgcatcag gataaacaaa gagataaggc gagtcaatct ctttttcaac tgccaagtat
    18901 ttttcaatag agttgataaa agggtcatcc ataatctcaa tagaaagcat cacttgggct
    18961 tcttcggccc agtcacaaga ttgtctcaag tttttgataa aacgagcacg ggtttcaggc
    19021 gatttttctt catagtaaac gtcataacca gctaattgaa tggtacgaac gcctaagtcc
    19081 tgtgccaatt caatacattg tttcatcagt ttaagagact tggcttcagt agcaggatca
    19141 tttgagccta gtgggtaacg tctatgacca gaaaaacaaa tggtcgggat gcgaatgcct
    19201 gtttcataaa tggctttcac taaatcaagc cgttcttcct tagtccactc taagcgcgct
    19261 aagcgagcat ctgattcatc gacagacatc tccacaaaat caaaacctaa gtcttttgca
    19321 aattgcaagc gttcacgcca ggtaaactgt tttggcgttg ctttttcata aataccaata
    19381 ggacgcgcca taaagttacc cccagatacg tttgatttca tctttgaagg cacgcgccgc
    19441 tgcagcagga tcttctgctt cagtaatgcc tcgccctgcg ataaaggtaa agacatcaac
    19501 cccttcaaaa agtttcaaag tgtctacatc aagcccacca gttactgaga cacgaaagcc
    19561 catgtcaatc aattttttca ccttgttaag gtctttttca ccccaagttt ctccagcaag
    19621 aagggcatca cgagattggt ggtaaatcgc ttgggaaatc ccagcgtcaa gccataattg
    19681 agcttgctca taagtccaat caccataaag ttcgatttga atttccccac ggtcaccgcg
    19741 ctcttcttta atagccttga gggctgcttc catggttgga atcgtcgcac agcaaatgca
    19801 ggtcatccag tcagcaccac gttttgcatt gtttttagcg accgtaccgc cagcgtcagc
    19861 acatttggta tctgctacga taattttctc tgggaagagg ctgcgtaata cctcaactag
    19921 ttcgcttccc acttgaagca aacaaacggt accagcttca atcacatcta cttcgtgacc
    19981 cacagcaacg gctgctttaa cagccccctg taagtcagaa tggtctaaag caacttgtaa
    20041 atttggaata tgtgtcatct ctttttccta aaactcttag ccaccgtgca aactggttaa
    20101 gagttcttat cctttcaata atgattgtga gtcgttttat ccgtttaagt cagtaagcta
    20161 tcgattaagc gtctaaatcc aaaccttcta aatacgggct attttttgat tcttctacca
    20221 tttctagaac ctctttagga ctttggcagg ccaccaagcg ttcaatggcg ttatctagtt
    20281 caaacaaggc cacaatttgt gggatagcca ctgttgtgtg aatagaaggg tctgtagcgg
    20341 ccaacgtcaa aagaacagaa acctctttac catctgagaa ggtgactggt tttgttagtg
    20401 taatcaaagc aaatgcattg cgattaacgc ctaaacctgc ttctgcatgg ggcatagcca
    20461 tacctggcat caacacataa taagggccgt atttttctgt tgatgcaatg atggcgtcgt
    20521 agtaagctga cgtcactgct ttgctatcaa tcaaaggttg aacagctaat tgaacagcct
    20581 cttgccaagt atcagcactt agccccaatc ggatggagtt gttgtcaata aaggcttgtt
    20641 ttaaattcat aaaaactatc tctttctagt gtcttgcttt gcaacacaca ccatttttac
    20701 tagttttatc ctactaaaga gaaagagctg aaaaccttcg tcacaactcc ttcgttttga
    20761 ttcagaatta gcttatagca cttcttgtag tttggtttta atttcattat catccatcag
    20821 gttatcaaga ccaaccaagt gacctttggt acgaccatca agctcatgaa tcaagtggtt
    20881 tgatgccact acaatatcat aaccagaagc tagaccttta gcttcaccaa ctgagcaaga
    20941 agctgactga atatctgtca caccaagttg acgaagcgca ttttcaactt tcattttgat
    21001 caccatagat gaccccatac cattgccaca tgctgttaat actttaacca ttgttttttc
    21061 ctccgaaaat gttttattat tattttgtta gaatagcaga gctatttctt aagatgcagt
    21121 gttattgagc ttccccacgg taataagctt ctttgtcctt agcttttgcg aattgcaatt
    21181 gtggaatggc aagtaagaag atgcaaacaa gcacataccc tgcaatacca aggaatttga
    21241 agaggtaccc aaatggtaac catggaagaa ccaagtcgat attaccgtga taaccacctg
    21301 taagtcctaa aagacctaca gcaacagcac caagtgcaac ttgcaaaata cctgagataa
    21361 atgatagagc taccgctgct ttccagccac cacgtttatc tgcataaacc gcaattgccg
    21421 cattatcaaa gaatacggga acgaatcctg tgataattaa gattggattt ttaaagataa
    21481 caagaagagc aatggtgatt aattgaccaa tcaaaccaaa ggcaaatcct gaaagcaccg
    21541 catttgaaga accaaagcca taggaagctg caacgtcaac cgctgggaat gaccctggaa
    21601 gcaatttgct tgagatccct tgaaaggcat tggtcaactc agaaacgaac atacgtacac
    21661 cttgcatcaa aatgaagagg taaacagaga aggtgagtga tgtttgaaga atatacatga
    21721 agaaagcttg cttagctggg ttgaaagcgc ctggtccgat taactctaca ttagacatga
    21781 tgtctggacc aaggacagcc aagatagctc caaagaagac taacattaag gttgctgacg
    21841 caacaacggt atcgtggaaa atatttaaga aggttggtaa ttttaagtta tcaaggtttt
    21901 cttctttttt accaaagatt ggagcaacct tatccacaaa ccaaatcgca aattgttgtt
    21961 ggtgaccaat cgcaaagcca ccgccacctg ttaggcgttg tgttgcttca accgtcatgt
    22021 ttgagctgac tgcccagtaa agaccacaga tgataccaac cgcccaagca ccaaaagcat
    22081 tttggaattg agggattaaa agaaggacaa agaccgaaat cgtcgctgcc tgttggacca
    22141 tgatgtgacc tgtgatgaaa agggtacgaa ctttagtgac cttgcgaagt gcaaccaaaa
    22201 gaatgttgac cccaaatcca atcaagagag ctgtcgtagc aacactgatg aagcccatct
    22261 cttctaactt agtattagca gcagccaaac caaaataagg atcaataacg gcggctttca
    22321 attcaaattt cttggcaaga gcaaccaaga tcggacgaaa agtcgttaca agaccgcctg
    22381 ctccaacgtt caaaatcaag taaccaacgg tagcctttac aaaaccagca aagacctcat
    22441 aaatgggttt tttaaggagt aaatacccga ttaaaaccaa aagacctaca aagaacgctg
    22501 ggttttgcaa aatattttgc gagaaccagt ttaggggagc taggagcatt tccataagaa
    22561 ctacctcttt tcaaagttaa taaagataaa gtgtttatat gttcattata ggtaatgaaa
    22621 gcgttttaaa aaagaccaac tatcacacaa agaagtgttc aatattagac ttaagttaac
    22681 ttattttaaa atttaactac acttaataat aaggaggaaa tacccctaaa caacgattaa
    22741 aaaccacaag aaccttcgtt cttgtggttt ttctagataa gttgcttttt gaatagatca
    22801 gctctttggc attaactgtg acgtgacgca aataaccact gaagggctgt gtcacctcaa
    22861 actatttgat aacaatatta acgagtttgt ttggtactgc gatgactttg atgatgtctt
    22921 tacctgcgat ttcggcttgg actttttcgt tagcaagggc aacttcttgc aattcttcgc
    22981 gtgaaaggtc tttagcaact acaagtttag ctttgacctt acctttgatt tggacaacga
    23041 tttccacatc gttttcaacc aatttgcttt catcataact tggccatggc acgtaagaga
    23101 ttgactcacc tgaggctgtc aaggcttgcc agagttcctc acctaagtgc ggtgcaaatg
    23161 gtgcaatcaa ttgaacaaag cctttggcat agtcgctaaa gagtttgtct tccttgttgg
    23221 ctgcattgac aaagaccatg agttgagcga tagctgtgtt gaatttcatt tggtcaactt
    23281 gctcagtaac agccttaaca gtttcgttgt aaaccttgtc aagggctccg ctattttcct
    23341 cagtgatctc tttagttgtg atcaaacggt aaacacggtc caagaactta cgtgagcctt
    23401 caagaccttc ttcagaccaa gcgatggaag cgtcaagtgg tcccatgaac atctcgtaga
    23461 cacgaagagt gtcagcaccg tactgctcaa caacatcatc tgggttgaca acgttcttaa
    23521 gtgatttaga catcttagct ggtgcttgtt caagctcttc accagtttcc acatggaaga
    23581 agctaccatc acgtttttca accttgtcag tcgctacaag cgctccccgg ctgtcgcggt
    23641 agcttgttcc caaaatcatc ccttggttaa agagtttttg gaatggctct ttggttggta
    23701 cgacaccgag atcgtaaaga accttgtgcc agaagcgagc gtagagaagg tgaagcacgg
    23761 catgctctgc accaccgaca tagatatcaa ctggcaacca ttgtttgagg agttcctcgt
    23821 cagccagttt ttcggtgtta tgtggatcga tgtaacgaag ataataccag cttgaacctg
    23881 cccattgtgg catggtgtta gtctcacgac gacctttaac accatcttca cgagtcactt
    23941 ccaaccagtc tgtcacgtta gcaagtgggc tctcaccagt acctgaagga cgaatatcct
    24001 tagttactgg aagaaccagt ggcaactcac tctcaggaac cgctgttgag gtcccatctt
    24061 cccagtggat gattgggatt ggctcacccc agtaacgttg acggctaaag agccagtcac
    24121 gaagacggta agtgactttc tcattaccaa caccttctgc ttcaagccat tcgaccattt
    24181 tagcaatagc tgacgctttg tccagaccat ctaggaagtc tgagttgatg tgaagaccgt
    24241 cttctgtaaa ggcagcctct tcaacattac caccttcaag aacagggatg atgtctaggt
    24301 taaattgttt tgcgaattcc cagtcacgtt catcgtgggc tggaacagcc atgatagcac
    24361 cagtaccgta gctggcaagg acatagtccg caatccaaac tggcatttcg ttaccattaa
    24421 ctgggttaat cgcatagcta cccgtccaaa caccagtttt ttctttggca aggtctgtac
    24481 gagcaaggtc tgatttgaga cttgcttgac gtttgtagtc agccacggct tctgcctggt
    24541 cagctgttgt aatagcatca accaaggcat gctcaggagc aagaaccgcg taagttgcac
    24601 caaaaagggt gtcaggacgt gttgtaaaga cagtgaagtc cttatctgta tccttaacct
    24661 tgaaggttac attagcacca gttgatttat caatccagtt gcgttgcatg tccttgattg
    24721 attctggcca gtcaacttct tccaagtctt ctagcaagcg ctctgcatag gcagtgattt
    24781 tgagcatcca ttggcgcatg ggttttctga caactgggta gccgccacgt tctgatgtcc
    24841 catcagggag aacctcttcg ttggcgatag ctgttcccaa ttcttcaacc cagttaacgg
    24901 gaacttcggc ttcgtaggct agaccttttt cataaagctt ggtaaagatc cactgtgtcc
    24961 acttgtagta gttagggtca gttgtattaa cttcacgatc ccagtcgtat gagaaaccaa
    25021 gagcattaat ctggcgtttg aagttagcga tgttttcagc tgtaaactcg gctgggtcat
    25081 taccagtatc catagcgtac tgctcagcag gaagtccaaa ggcatcccaa cccattgggt
    25141 ggaggacatt gtgaccttgg gcacgtttga aacggctgag aatatcagtt gctgtatagc
    25201 cttctgggtg accaacgtgg agaccagctc cagatgggta tgggaacata tctagggcat
    25261 aaaacttagg ttttgatgcg tctgttcctg ttttaaaggt gtgattatct gcccaaaagg
    25321 cttgccattt gggttcaata gcggtgtgat cgtaaaatgt catgtgaaat ctcccatgta
    25381 aaaaatctag tcttcttatt atagcatgag atgaagcttt taggaatggt caagacatga
    25441 ctagcacctt ggcttttgag acttcagacg attagctatt tttaaaccct gctttagcat
    25501 caaccatcct cacaaaaagc taataaaaaa agccagattg gctctgtaaa cagagccaat
    25561 ctggacaaat agacttaaaa agcaagtgct tgctcaaaat cggccaataa atcttcgata
    25621 ttttcaacac cacaagacaa gcgcagcaaa ccatcaacaa ccccttgttc caaccgcgct
    25681 tgtgacgata aacaagcatg agacatcgtt gctggatgtg acaaaatgga ctctactcca
    25741 cctagactaa cggctaaaat cggcaactga atacgatggg taaaggtcat cagctcctcc
    25801 ttagaagcca actcaaagga taaaacagca ccaccattct tagcttgttg caggtgggta
    25861 tcgtgattag gatgactgtc taagccaggg taatgtacct taagaacttt ggggtgcttc
    25921 gctaaataat tagcgagctg ctgagcattt tttaccgctt gttccatacg gatccccata
    25981 gttttcatgc cacgaagaat cagccaagcg tcttcgaccc caacaattgc tccaaagttt
    26041 ttttgaaaaa gcttgagctg gttgtagata gcctcattat tggtagcagc taaaccagct
    26101 accacatcac tatgaccatt gataaatttg gtcacacttt ctaccacaat atccacaccc
    26161 atagctaagg gttcttgata caaacttgtc ataaaggtat tatcagccac agttagcaca
    26221 ccataagctt tggcgagttg cacaagctct gaaatatcac aaattttcaa gagcggattt
    26281 gacggtgtct ctagataaat catacgcgta ttaggtctga tacttgcttt tactgttgct
    26341 aaatcagcca tatctacaaa gcttgtttca atctgataat tgggtaaaat agctgtcgca
    26401 aattgacaag tccctccata gacctccaat gggaaaatca catgatctcc ggcttttaag
    26461 agcatcaaaa cagttgaaat agcagccata ccagatgcat aagccaccgc ataagtcgct
    26521 ttttctaaac aggctaaccc gtcttctaaa gcttcagtcg ttgggtttga aaagcgtgtg
    26581 tacaaatgtt tttgactagg acaatacagt tctgaattgt ggaacgtcga agtctgatag
    26641 atgggaactg aagctgctcc tgtaaactcg tcaataaccg tatagccatg taataaggtc
    26701 gtattttctc tcatttcgtg cacctccgca atagcgttaa ctccaatgaa ctctctttta
    26761 gacaatggtc ccaccccaat ggttgcacaa accaaaaagc tcttcaaaaa agcgtgatct
    26821 gctaacctat aagaaaagta gtgggcacct tttaaatgaa taatgaattt ttccaacaat
    26881 atcattttta gatcgattac atttattata caacctttag ctaagtttgc aagccctttt
    26941 atcatctttg accaagctgc caacacctct ccagcaagtt aaagtatggc tacctttggc
    27001 cccatcgtct caaaagctta gcttatcaca ctgacagtcc taccttgcat cgtcacctac
    27061 ttaatagggc aatagtgcca tcaaactttc atcaaaaggt cacaatttat ttcatttaat
    27121 gagaaacaga acttgttttc accatgcgcc ttatagtata ctgctaaaat actatttatt
    27181 tttaggagag aaatatagtg aaaaacaaat tatttttagt tgccctcgcg accataactg
    27241 tcctagggcc ctttttagca acccctcatc accagaccgt gcatgcggct gagcagacag
    27301 taactaaaaa aacagctact gaaacatgta cattagatgg aaaaatatgc tacggttatg
    27361 aaatatcaat gaagaccaca ccgatagcat ggttcaatct gagtctcaag agcaaggttt
    27421 cttcagttgg ctttggacac aaataacaac ttggttttcc tcattaatga gctaaaacca
    27481 tctcgtggcg gttttataat cctaggtcgc cacacttttt attcaggtaa ataataataa
    27541 aaacattaaa ataatacttg atttattaac aaaaagttag tataatataa tcacaataca
    27601 aattaaagga gttataaatg aaaaagaaat tatctttatt tatgatcgca actgctgctg
    27661 ttgcaagcct tagccttgca acactaggaa gccaccaaac tgtttcagca aatgatgcta
    27721 gctatagtaa cggtttctac ggacacactg gtcctgacag ctggttactt tacacagtat
    27781 ggtaaacctc ataccgtaac atagaagcta tcttcttcgt aagactacgg ttatgaaaag
    27841 cctaaagctg cataagcagc cttaggcttt ttgattggct aaaacgtttt tgccaatgac
    27901 ccctcaaggt aaaaaagaaa agacactccg cctataaaag gagagaagcc caaaacacaa
    27961 gtcgtaacag ttgctagcta accaccacca aaaaagctgt aacacctcaa atataatgat
    28021 aaccagatta acattattaa taattaatgt gatttatata agataaagaa atgctttagt
    28081 attggctttc tttgcctttt tcggtcaaac atataacaca aagattaaaa tgtgatattg
    28141 aatcattaat agaatatgag tataatatag gtatactata atttaaggag ttataaatga
    28201 aaaagaaatt atctttattt atgatcgcaa ctgctgctgt cgtaggcctt agccttgcaa
    28261 caccagaaaa ccaaactgtt tcagcaaatg cacagacacc agctgttcaa aactgtgaaa
    28321 acggctgttg tgaccgccct ttctttgggt attgtggacc tttcagctgg ctttactata
    28381 atacaagata ttttttgggg tattctgata cagctactaa ccaataaatt tgtttctata
    28441 gtgagacaaa agcccaagcc tgtttacgca gtcctgggct tttttgctgt cctaaagtca
    28501 gggtgttgcc acagcttcaa atccaaaaac aattaaaccg caccccaaca attagacata
    28561 ggctatgtct ccagaatcct ggacacatat cactaaagcc taatgattaa ggtgcagttt
    28621 aaggtgtggt agcaaggaac tgttttaaat tcgtctgcgt ctaactatac ccactggcta
    28681 tggagtcagc ttagagttga ttgtcaaatg tcaaatcaac ttcccccacc aatgtaaaat
    28741 gattccccat ataaacttga caggaattaa caaagggtag ctttctccaa atccttcatt
    28801 ataaccatct ctgtatccat ctttataccc ttctttatta gcctcttcaa tatcactagg
    28861 tggttcttgg tcaggcgggg tcaaatcagt ccaatcggct gccttgccag cttctttccc
    28921 ttttgtcaaa ccctgcttat agcctaatat ccaaggatca ttctcctcat ctgccataac
    28981 aggtcgtgct ataagcaaca gagcagcaaa tagagccacc aagaggtaga cgaagcgtag
    29041 aggctggtaa gattgttgtt tcatgataat agttatctct cccttttatg ttatgctgtg
    29101 cttgttaaaa agcagcttat tagtattata gattagaaga agcttagctt caaggtcact
    29161 atgtgagaaa agaataactt tttgattagt atatcaaaaa agcttgtcta tgaaggtatc
    29221 tcatagacaa gcttttttct gtatttgtga gaggagtagg cacaagatct caagagataa
    29281 gcagcatcaa ggtgcttgac gaacctcttg aaccagtcct atttataagt aatcgaacca
    29341 tatgggctca gggttgatcc tgagatgttg acattgattt ctttagacag tttcacatct
    29401 ctttcgtcga tcacttttcg ccaccattcc caagctaagc cggtgcactc tctagccatg
    29461 atacgtatat ttcgtgaatt agctcctagt gggataactg tgctaaatgg tgatgtctta
    29521 ctataccagt tgttgtccca acgtcgtttt gtaatcactt cttttccttt gtcatcataa
    29581 ttgatttcat cccaaaggat ttcatattga gcaacatacg cgccttgatg agacaggtta
    29641 atttttccac tagtgtactc ggtagatgtt gtttcaacgt attcagttct gttattgaca
    29701 cccgcaattt tattattttt aaggaaaaca ctggtgtatg aaataggata agctgggttt
    29761 tttctactga aggtagcatt gtctttgata acgtttctaa taacatcaaa gtcttttgtg
    29821 actaccttat tgtgctctgc agcatctcct cctaaaacga cagctgtaaa tgagctattt
    29881 tctaagatat cagaatattt tccattagtt ttaacatctg ttccttttag agctgcacta
    29941 aaggccgctt caacatcatt acttttagaa cttgtttcta gtttgacaaa aacagttcga
    30001 ccataggcta cattactcac aaagagtggc ggagcttcat tgctgacacc ttttcgttgc
    30061 aactctttaa aggtcactga tttagcaaac acatccgcag gattattagg aaggtttgct
    30121 gatacagtgt aaaaaatttg cttgtatgct gcaatcatca ccttcttttc accttttgaa
    30181 atcgacttga aatcaatgcc taaagtacca tctaagattt tactattaac atttagagct
    30241 gcttcaatct gtgacttaga atataccatt gattcagtat attgtgttct ggcaggaagc
    30301 gtattaccac cagaataatt atcatgccat tggttaataa gattatcaat agctgttgaa
    30361 acattggcat aggtagggtc attgacctca accgttgctt tgtctcccat acctggtaaa
    30421 tcaatatgga ttttttgtgg gtttcgcttg gtgactaccg cgtctggttt gttttcggta
    30481 aaacctttat tagccagctg aagggctgct ggataggtcc tatcagtgac agagtcaatg
    30541 atggaaatat cgactggtgt agtgttgata ttttttttct ttctttcaat gacaataaat
    30601 ttatcagctt tcttaacgcc ttctttagga gcaaaatttt caatggtttc accattttta
    30661 gcaagtactt caagctcatt ataatttagt gaataaatct tgtcattgat ttcttcagtg
    30721 tgatcttctt cgctcttttt tttgtcttct gacttttttt cttctttttc tgcagattct
    30781 agtggcattt ctttgggagc aagcttaatc atatcgttag agttaagcat atcatccgtt
    30841 ttctgacctg ctttttcagt agttagctca ctactttctg gctttggttg ctcatttgtc
    30901 gttgtggttt ctgtactagc agtgttttgt ttgttcgatt cagcattagc agtaacaaga
    30961 ttaccaatga taagagctgc cgtcagtagc ccagcgacgc gactgtattt tttaaatgtt
    31021 tttttattag acatgtcctt catacctttt tatcattcta aaatgttttt attgttcttt
    31081 cgaccatatc aagcatagta tcttgatagt gagcaaattc tcctaatttg taatgtgcca
    31141 tagcctctct aatatgcgca tcttttaaca ctttggtcat attagctagt atgctttgac
    31201 ggtttaaata aaatggcaag ctttcgtaat aatttaataa catgttttca gcgtttaggg
    31261 tttgaaccgc ttggtaaatg tctaatgctt gaccgctatt tgacatttct aataatgctt
    31321 cttcgatgtt agctttcaat tgggtatagc cttttatgaa agcagggtaa accccatact
    31381 ctaaaataac ttctggatca gaaatatctc ccatatagga gtctcttcta gtgatacgat
    31441 actctttgtc actacctatc aagtattttt ttaaatcatt aacagttact tctttttgaa
    31501 acattttttg gtaatgttct aaaccctttg gcaccttata catattgtta cttcctatct
    31561 tgcattctat cttgcatttt cttaattttg aagcgaccag ttactttttt atggtcacca
    31621 tttggagcaa tgatggtagg atcaataatt tcaaaatagc ctttggcatc aatctctgct
    31681 aagacagctt tagattttag atctttaaca ctaatcgatg ggaaaattaa ctcactttct
    31741 gaattttcaa tgtgttttcc tgaccacgtt tggcaaccag gaatgttgag cgaatttgct
    31801 ccaggagtat ctccgctagc tgttcggata tagcctagct tatcaatgtt ttttgttagt
    31861 tcagaatcgt actcatattg ataaacccca tcgctatatt ttccgctatc gacacctttt
    31921 atattttcaa tttggtcagc tgattttaac ttaccttgat cagtaaagag caatgccata
    31981 tcttcagcaa aacttgtcac aaaaagaccg ttttcttgtc gaccaatcgt tgactttctt
    32041 ttagcatcat caaaagctaa catcaaatct tttttacttg taacgtgaga agctccgctt
    32101 tctttgtaga cttgttttag tttttcaaca aactcttttt tgtactggta tttgcggcta
    32161 acatacatcc ggtaatactc agcacgtgac gcaacagcag acatctgaac agctttatca
    32221 gcatacttat cggcagtttc aataaactca tctgcttgtt tatctgtcac ccatttatct
    32281 ttaatttctt taaacttttt ttcaaaaaga tcgcgttcca tattgccaaa agtgacctct
    32341 gacaaggcta aaatatcctt gttttgtccc tgatggacct ctgttacctc aatatcaata
    32401 cgatcaacat ctaatttttt atcaatctca atgtgatgcg gttttttagt gtaggtgtcg
    32461 cctaattcaa ttttttgaaa gaggaccaat ttattcccgt tatagtattt aacatcagcc
    32521 tttgcaattc tatttttctt gtagtaattc tccttgctag atgtgtctcc attaacaatt
    32581 aaaattctcc caatatgcat cggggacgca aacttgtagg aaagtacctc accaacacca
    32641 ccaccaggtg aattttcctc ccaaacagta ctcattgagc cgtctaatgt gtgcatgaca
    32701 tgattgtctt ctttagagga agttgcgtta gcttccataa ctttggtcgt ttcatatttg
    32761 acatcgcttt ttttattttc tttgccacta acagcgtacg ttgtgctatt agctaataaa
    32821 ctgctaccca ttgctccagc caaagcaata gcaacacttg tctttgcgac aatatgagct
    32881 aatgttactt ttttgtttct catgtaaacc accttatatt atttttaagt aaactataca
    32941 ttaacaacta gtttttgtca atgcgcttta ttaacatcgt tttaggcttt tctatcaaaa
    33001 aaatgaacac aaaaaaacaa gtagccaact gttacaagtt tcaaggggat atttccatct
    33061 tattatcaca gaaccttcac atctgttcta tttaaaccag attaaaagta ctagttaaat
    33121 atttgatagt agcaccgtta tcagtaatag atctgttaat tatctctgat tacaatgatg
    33181 ttaacaatag tcatccattt gtttgtaaac acgcttcact gccaactaaa aaaggtctga
    33241 tggtaatatt tataccatca gacctttgag agcctatagt tctgcaattt gataaagttc
    33301 aacttctgct actgtttcag agccaaacat gttgagcatc agcttcactt tgttgttttc
    33361 gatttctacc acacgacctt cttgtcccat aaaggcaccg tcgatgatct gaaccacatc
    33421 gccttctttg atattggtat caaagacatc aatggtttga cccatagaca acaagatagc
    33481 acggatttct tcttcaagaa gtggtgttgg ttttgatcgg ttcccgtgtg atcccacaaa
    33541 acctgtaacg tttggtgtgt tacgcacaac aaaccaagct tcatctgtca tgaccatttc
    33601 taccaagaca taccctggaa agcgattttc ttcgatttct ttggtttgcc catttttttc
    33661 aacgttaacc gtttgtgtcg gaatttcgac gcgcaaaata ttgtccaaca tgttataggt
    33721 ttgggcacgt tgcaagaggt tttcttttac tttgttttcg tagcctgagt aagtttggag
    33781 gacgaaccag cccttatcaa atgaatctag catgatgttt cctttcatta taaaaaagcc
    33841 ctttttttgg cttttgcgct gttttctatc accttcatta taataaaagg cagggctgct
    33901 gtcaacgtat ctgtggagct acttgacacc tttattaaaa agtccaaagt cggttcgtga
    33961 cgactctgga cggtattgta cagttttagt tttcaggaac tgtgatggtt ccttcgataa
    34021 tcgctttttt agcagcctca atagcttttt tagtgtcttg tgtcagagca tccgttgtaa
    34081 ggctaacacc accttctttt aaaccaaaag tggttatttg accacctggg aattggtctt
    34141 ctgaggtttt tacggctact tttactaaag cgtttccgac ttccttgata cttgaggtca
    34201 aaacaaaatt agctgacttg ccatcttttg tagtgtattt tccatcttca ctttggtcac
    34261 ggtcaacacc aataacccaa accttatctt cttctttacg tttttcgttg atagacttag
    34321 cttcgctaaa gacacccgcc cctgtgcctc ctgctgcatg ataaataaca tctgcgcctt
    34381 cagcgtattg agcagctgca atcgtcttgc ctttggcagc atctgcaaaa gagcctgcat
    34441 aagcaactct tactttgatg gtatcatcta ctgatttcac accagcttca aaaccttttt
    34501 caaagcgctt gacaacatct ccttccatac cacctacaaa accaacttgc ttggtttttg
    34561 tcgttttagc tgctgcaaca ccggctaggt atgccgcttc atggtctgaa aaggtgatac
    34621 ttgcaacatt tttttgacct ttaatcacat catccacaat tgcaaaatgg ttgtcaggat
    34681 tgtttgcggc tactttttct acagcgtcat gtaatggaaa tccaatccca aaaacaagat
    34741 tataaccatt ggttactgct gactcaaggt ttgtggtaaa ctctgattca ttggctgatt
    34801 ggaaataatc atagcctttt cctttttcaa gtttattttc ttttccccaa gcttgtaagc
    34861 cttcccaggc tgactggtta aatgacttgt catcaatacc cgtctgatta gtaatcatag
    34921 cgatttttaa tgaattgtca gttgtttgtt tagcggagtt attggtacag cctcctaatg
    34981 tgaatagggc agtcgaaaca agaccaagtg acattacttt tttgttcatg tgaaaatgaa
    35041 cctcctaaat gtttaatcct aaagtgatgt gtcattgtta acgttctact tatgctctag
    35101 aacgaaaagt ttagtatatc aaaaaaatca gttttatcct actatttttg ctgaaaaatc
    35161 tctttttcac caaaatgacc gaacgagaaa gtgagatcaa ctggtaaaac ccattatctc
    35221 cttaaaaatc acctcttaag gagataagac aacgacaaaa ctcaagcaac tagtaatagc
    35281 atgactaact atacaatcca acaaacggta aaaagagctg gaaacgctat ccaactcttt
    35341 gtcatactag acaccttaga tagatgccca gactgactca agaatattgg tctgttcacg
    35401 ccctggacca actgagaagg ttgaaatgcg aacgccaacc aattctccaa cacgacgaac
    35461 gtagttgcgg gcattttcag gaagctcttc aaggctacga acacctgtga tgtcctcttg
    35521 ccagcctggt aattcttcat agattggttt gcaacgtttg agttgttcaa ggtttgctgg
    35581 gtaatagtca atacgtttcc catcaaggtc ataagccaca caaatcttaa ccgtatcaag
    35641 ccctgaaaga acatcaattg aattcagaga gaggttagta atacctgata cacgacgact
    35701 gtggcgcatg acaaccgaat caaaccaacc gacacgacgt ggacggccgg tcgttgtccc
    35761 gtactcatga cccacttcac gaatgcgctc acccacttca tcaaagagtt ctgtagggaa
    35821 tggcccatca ccgacacggc ttgtgtaggc tttacagaca ccaactactt tgttgatttt
    35881 acttgggcca acaccagaac caatggttac accaccagca actgggtttg aagacgttac
    35941 aaatgggtac gttccttggt caatatcaag cataacccct tgtgcacctt caaaaagaac
    36001 acgtttaccg gcatcaagtg catcatttaa aattacagaa gtatctgtca catattgctt
    36061 gatttcttga ccgtaagcat agtattcttc aaaaatagca tcaaaatcaa gaggtgtact
    36121 gtcatacatt ttttcaaata aacggttttt ctcagctaaa ttaatgcgta ggcgctctgc
    36181 aaagatatcc ttatccagta aatctgcgat acggatacca actcgagcag ctttatccat
    36241 ataagctgga ccaatccctt taatagttgt tccgatttta ttgtcacctt ttgcatcttc
    36301 ttgcagttga tccagctgga tatgataagg taaaatgacc tgagctcggt ctgaaatgcg
    36361 aaggttatct gtcgtcactc cttcattatg caggtacgcc aactctttga ccaaagattt
    36421 ggggttgacc acaacaccat taccaataac ggaaattttt tgcgggaaga aaattcctga
    36481 tgggatcaag tgaagtttaa acttcttacc atcaatcacg atcgtatgac cagcattatc
    36541 accaccttga tagcgagcaa ttacttctgc atccgctgac aagaaatcag tgattttacc
    36601 tttaccttcg tcaccccact gggtaccaac aacaactaca gatgtcatat cattgtccta
    36661 actttctgaa acacttattc tcaataaaaa tcataggcaa gctaaccact gcttaaaaac
    36721 caaaaagaag gtcagatctg taagatcagc aatgtagctc ttgatattta aggaaaacag
    36781 gcaggaatct cacctgctag catatatctt acaacttatt atagcaaaaa atggtttttt
    36841 ctgctagatt tcttagcatt attaaggaaa aagagaaact ctttttttaa ccatgataaa
    36901 caatcctaaa aaaacgaaca ttataagaga aaagctttta acctcgtttc tcctaagctt
    36961 tagcagggtt aaacgattct cttaaaacat tagctctttt ctttcagaaa tagcggtttt
    37021 aaggtaaaat aatagtaagt tacctctatg agatagccag taaaaacata tcgaggaaat
    37081 atcacatgat tagaaagcat gaccgcacga gcacaaaaaa gaaatcacta aactggattt
    37141 ggctaatcat tgcttttttt atgatttcaa gctttatagg tggctcttct tttactgagt
    37201 cacttctaga cattttgcct gccatagcca ttggtggtac aggttatgct atttttcgtg
    37261 ttagatctca tcaaaagcgg ctagcaaagg ccaagattgc caaacaatta gaagatctaa
    37321 aagcaaaaat tcaactagct gatcgtaaag ttcggctgtt agacacttat ctggcagacc
    37381 atgatgactt ccaatataac gtacttgctc agcaattatt accacaactt agtgacatca
    37441 aagcaaaagc tattacgtta aaagaccagt tagatcccaa aatttatcgt cgtatcacca
    37501 aaaaagccaa tgacgttgaa agtgatatta cccttcaact cgaaacactg cagattgcca
    37561 caactcttaa ccctcagcct ttgaaaaccc catctcctaa tcttattaac aaagcacctg
    37621 agctcaaacc gtattatgat aatattcaga cagatcatca agctatcctt gctaaaatcc
    37681 aaggagccga caatcaagaa gaattgcttg cgctgcatga agctaacatg aggaggtttg
    37741 aggatatctt aacaggctac ttaaaaatca aagaagagcc taaaaattac tataacgctg
    37801 ctgctcgttt agaacaagcc aaacaagcta tccaacaatt tgatgaagat cttgacgaaa
    37861 cccttcgtcg actcaatgaa agtgatctta aagattttga tattagcctt cgaatcatgc
    37921 aaggtgctac tcaaagacga acaacgcatc accaaaaaga ctaaaggagt ccctttatgg
    37981 cagattttaa ttttgacatt gaccaaattg ctgacaatgc tgttgtcaaa accgataaaa
    38041 ccaccgatat tatctcagac ttaccaactg acacaaatgg ccaaatctct ttttttgaga
    38101 aactaagtgc tgaccagcag acagctatta ctgccaaagc cccggcattg gtagatacct
    38161 ttttggcaga ccaaaatgcg ctacttgatt ttggtcagtc tgctgttgaa ggggtcaatg
    38221 caacggtcaa tcatatcctg gccgaacaaa agaagttaca gattcctcag gttgatgatc
    38281 ttttaaaatc aaccaatcgt gaactcaatg gttttatcgc taaatacaag gatgccacac
    38341 ctgtggacct tgataaaaag ccaaactttc ttcaaaaact ctttaaacaa agccgtgata
    38401 ccctgaaaga gttttatttt gattctcaaa acattgagca aaaaatggat agtatggctg
    38461 cagcggttgt caagcaagaa gataccttag ctcgcaatat tgtctcagca gaattgttaa
    38521 ttgaagataa tactaagtct attgaacatt tggtaggcgt cattgctttt atcgaagcta
    38581 gtcaaaaaga agctagtcag cgcgctgcgg ctttacaaaa agacctaaaa accaaagaca
    38641 gtgctacacc agactatcaa ataaaagctg atcttttggc aagaactacc gaagtcatca
    38701 acaccctcga acaacaacac accgaatact tgagtcgcct ctatgttgct tgggcgacaa
    38761 ctccgcaaat gcgtaatcta gtcaaggtct cttctgacat gcgtcaaaaa ctaggcatgt
    38821 tacgccgcaa taccattcca acgatgaaac tatctattgc tcagttaggc atgatgcaac
    38881 aatcggttaa atctggaatg actgctgacg ccattattaa tgctaataat gctgcccttc
    38941 agatgttggc ggaaaccagc aaagaagcca tcccagcatt ggaacaatca gcacaaaacc
    39001 ctactttgtc tatgaaatct gtgacaagtc tggcagaaag tttagtagca caaaataatg
    39061 ggatcattgc ggcgattgat catggacgca aagaacgagc acaactagaa agtgctatta
    39121 tcaggtctgc cgaaaccatt aacgattctg tcaaactacg tgaccaaaat attgtgcaag
    39181 cacttcttag tgaaggcaag gaaactcaaa aaacaattga taaaacaact cacgcataag
    39241 ctaaacatca cctgtcacgc tacttaaaaa gcaagccatc agttaggtta atccctttga
    39301 tggcttgctt ttttactact taacgaataa tcgccttgtt tgatataaca cttatctttt
    39361 atgatgttat tttcataata cgaacaaggc tagcacgctc ggcctcttct aatttcaact
    39421 caatgtagtg aatcgtctct tccagttgcg ggataataga atactctaag ccattgacgc
    39481 gacgtctagt cttttcaatg tcatcagcca ttagttgaca agttttttca acttcagcta
    39541 accgtaagag cttttctaat agttcttttg tcttttggat agtattgtcc atctcactat
    39601 ttgagctgag gtaactataa gcaaactcac cttgttcttg ctctcttgcc gtattagact
    39661 ggacatggaa tttaggcaca ttgacactca tgatattttc aatatcaatc cataaggtca
    39721 cttcatggac tggaacagca aagagttctt ctaccattag actattttcg gatgcttttg
    39781 ccaagacaaa ctccttcata ttggcagcaa gttctttttc gatagtttga cgaagctcat
    39841 tgttttcacg aattaaatca acgaagcggc gcatcaattc atctcgcttg tcctttaata
    39901 atttatgacc tcttgtagct gtcttcaagc gatttttcaa gttactaagt tccatgcgtg
    39961 ttggtttaac atttaatcgt gccattgata taactccttt cgtcaagggc ttgaaattgc
    40021 atggtcaact caatcatttg caacaaaaac ctttgtcatc gtggtatctg ctttaggcaa
    40081 ataacgatct aacatatcat ctttaatgcg ttttaattcg gtacgtggca aaatcgacaa
    40141 caattcccaa cccaagtcaa gactttcttc aatgctacgg ttggtgtaaa atccttggtt
    40201 aatgtattct tcttcaaacc ggttggtaaa ggccacatat agtttatccg tttcagaaag
    40261 ggctgattca ccgagcacaa cagccaattc cttagcttgt tttccttggg cataggctgc
    40321 aaagagctga ttcattgtgg cagcatggtc ttgtcgagtc ttaccttcac ctgaaccttt
    40381 atcttttagg cgagatagcg atggcaagac attaataggc ggtctaaaac catttttata
    40441 tagttcttgc gacaaaataa tctgaccttc ggtaatataa cctgtcaaat cggggatagg
    40501 gtgggtaatg tcatcttctg gcatggttaa aataggaatt tgagtcactg accctttttt
    40561 cccgatcaag cgaccagccc gttcatataa ggtggagaga ttagtataga gatagccagg
    40621 ataacctcgt ctgcctggaa cttctctgcg agcggctgat acttctcgta aggcttcaca
    40681 ataatttgtc atatctgtca tgatgactaa aacatgcata cctttttcat aagccaagta
    40741 ttcggctgtt gtcagagcta tacgtggtgt tgcaatgcgt tcaatagcag ggtcattagc
    40801 taaattaata aataaaacag atcgatcaat ggcacccgtt tcacgcaagt cattcataaa
    40861 gaattctgcc tcttcaaaag taatacccat agctgcaaac acaaccgcaa agttatcatc
    40921 agagtttaga acagttgcct gacgagcaat ctgtgcggcc aattcattat gaggtaaccc
    40981 tgagcccgaa aaaactggta acttttgacc acgaacgagg gtattgaggt gatcaatagc
    41041 tgagatacct gtctggataa attcgtctgg gtaatcacga gcgacaggat tgatcgcttg
    41101 accatcaata tcaaggtatt tttcgggaat aagttctgga ccgccgtcta tgggctgccc
    41161 cattccatca aagatgcgcc ctaccatatc ttctgatacg gctaattcca aaggatgccc
    41221 tgtaaatcga accttggttt tggctagatt gatgccagtt gatccttcaa atagctgtac
    41281 catagccttg tcaccttgga cttctaagac ttgaccttta cgcctttctc cattatgcaa
    41341 agtaatatct accaattcgt tgtagtgcac tcctgcaact tgatcaacaa tcatcaaagg
    41401 accaaccact tcgctaaccg tccgatattc tttgagaacg ctcatctaaa ttcctccctt
    41461 tgctaaaacg tggtgaatct ctttggtaac cttctgagta agccctttaa tctgctctaa
    41521 gttttcttct gggatgaatt tgctgcgtgc gatgcgatcg cgtacctgag cagtgccttc
    41581 cataatctca ttaaaataag ctcccaaaga aagggctttg ctggcttcct cattaaaggt
    41641 caaaatattg gttagcatgg cctcttgttt cggaaaggaa gtaaaggtat ccaccgaatc
    41701 aaaggcattt tgctggagat aatcctcccg aatttgccgg gcaacagcca tggtcaaacg
    41761 atcttgttca gacagtgaat caagccccac caagcgtaca atttcttcta gactggcttc
    41821 acgctgcaaa atagccatgg cacgagttac cttgttggac caattagatt gctgtttacg
    41881 gtcaatatag cttcctacat catcttgata caatgaataa gacgtcagcc agttaatcgc
    41941 tgggaagtga cgccgttgcg caagaggcgc gtcgagcccc cagaaaactt tgacaatccg
    42001 aagggtgttt tgagtgacag gctctgaaat atcccctcca ggaggagaaa ccgcgccgat
    42061 ggctgtaatg gttccctcac gttcttgact tcccaaggtc cgaacacgac cagcccgttc
    42121 ataatattcg gcaatgcgac tccctaagta agccggatag ccttcatcac caggcatttc
    42181 ttgtaggcgt cctgacatct cgcgcagagc ttctgcccaa cgtgatgtcg agtctgccat
    42241 gatagccaca gaatagccca tatcacggaa atattcggca atggtaatgc ctgtgtaaat
    42301 cgacgcttca cgcgctgcta ctggcatatt agaggtgttt gcaattaaca ccgtgcgctc
    42361 cataatggac tggcctgtat ttgggtcaat taactctgga aactcattca aaacgtcggt
    42421 catctcgttg ccgcgttccc cacaaccgac ataaataaca atatcaacgt tggcaaattt
    42481 agctatttga tgctgcacaa ctgtttttcc tgccccaaat ggtccaggaa cggcagcggc
    42541 accacctttt gtaacaggga aaaaggtgtc aataacccgt tgacctgtaa ccaaaggctc
    42601 gactgggata agcttttgag caacagggcg actttgacga actggccaag tctgcatgag
    42661 gctaccttgg taaatggaac cgtcttcctg cttaatttca taaactgtat ctgttactgt
    42721 gaagtcccct gcatgaatag ccaccaaggt ccctgaaact ttataaggaa ccatgatacg
    42781 atgctcaatg acagctgttt cttgcacagt tcctaaaata tcacctgcaa ctacttcttg
    42841 accaacactt agcttgggaa taaatgccca cttagccttt cgatcaagac ttgggatagc
    42901 cacaccacgg attaaaaagt cgctgtccgt tgctttttga aaacgatcaa gcggtcgctg
    42961 aataccgtca aacatttctg aaatcaggcc tgggcctaac tcgaccgaca aaggacaacc
    43021 agtagtcact actggttctc ctggaccgat ccctgatgtt tcctcataaa cctgaataga
    43081 cgcttgatcg cggcgcattt caataatttc tccgactaag ccaagatgtc ccacacgaca
    43141 aatatcttga atattagctt cttgcatccc agaagccaca acaagaggtc ccgaaacggt
    43201 tattattttt ccttggttca cctttttcct cctttatttt ttccaaatca tactaactaa
    43261 tctatactgt caaggtttaa tgtgactatt ttgaatagtc agcaaactat cctatgcgtt
    43321 cagctgctaa cttcaccaat tttcctgtcc ttgcatttca tcagttagct actcataagc
    43381 ctcaaacaga gtataagtcc tctttgcata acgtcttagt gttataaaat attttgaccg
    43441 acagcctttt caaccatggc ttgtatgcgt gacaggccta tcccttgcgc tccttgatga
    43501 gttggtaatg gtatgactgc tggtagaact tgattgtcat agtgagtgag ggcttctgga
    43561 atagctgcag caatatcttc tgtgatataa ataataccat agtcttccat tgctagttga
    43621 cgcaactggt taatagcgtc ttgtggtttt attactggaa aagtttgaaa cccaatcatc
    43681 tgaaaaggta gaataacatc tctgttacca attaccccga ctttatacaa tgttttggtc
    43741 atgctattgg tctcatcctt tctatgacac gttctttggg taaatcatta gccaaagcag
    43801 ccgctaaaag ccgtagattt tttacttcaa acgatttagc gagcaaaaaa cgagcaagca
    43861 cataaggccc atcgacttga tatttggcct tcgcaaataa atggtaaagg cattcatcaa
    43921 caaggtattc taactcagtc gtttgaagag tgccttggcg aagtttctct gaataaggtt
    43981 ttagggctgt catatagcta tcaggtgtta cattttcaaa ccacgtcatc agatccttat
    44041 catcttcaag tgtgataaat gttttacttg gtctacttgc ttcatcagat aataactgca
    44101 tcatgaaact tattggttta ttttgcgatt tggcccgtct gacggtaatc agattataca
    44161 aatcaatcac aataagaaca gcttgttgga aaacagggtc ctctaatctt tgtgctattt
    44221 gtttcaacgc cttaaaataa gctaagtcag taccaatttc taagacgcgt atgtcttgat
    44281 aatcttgata ttcggcccaa atggactgga tttctgttac cacctctttt ggaaactcat
    44341 cagaagtcat cgtcctaatc aaatgttcca aagccgccaa aggcttgtca ccaattggta
    44401 gtaataagtg actcagatct gcttgactag ctttagcttt taacaacact ttgacattat
    44461 gataggtgta acgcaaggta aataattgta ctatgtcagg ttgaggggtt tctgcaaaag
    44521 cccagcgata ggtcttggtt agctcagcca ttaagataga ttctagccga tccaaatcgt
    44581 tgagatcgtc aacagttagg tgatagactg actggtgcaa cagtcgagct aaggttgttg
    44641 tattgggagc ctgcaatagc ttatcaaatt gctctttagt caataactct ttttctttga
    44701 cactgatagt agtgtttaat tctagaaatg ttggcatcgc tagtcaaacc tcctatatct
    44761 ctgaaaaaag catatcaatg atgcgggagc tttcttcttt aagaactgat tctaaaaggt
    44821 aacggtataa ataattgtca tcgacttggt ctaaactgac taaaaatcct gcttcctgag
    44881 gaattagctc ttgattatag cttaattgag gaaatgctag tctcagctca gcacaatcat
    44941 aagaactgaa cttttgccct gttttttcgc caaaagtaac ttgcaatggc tgttctggat
    45001 atttagacaa gacttgcttc aaaaaagcca attcttcttc cttagaaaag ttcgtcatct
    45061 tctccaaaga agcttcaaat agctccttta tactgtcttg ttttaatgct agtagagctt
    45121 gtctttcttg gtttttgagt tgctgctgcg caacctgaaa ttgctgttca agagccttta
    45181 actctttttg acgctttgct tttaaatcgt gtagtccttg ctgttgacgc tctttaaagt
    45241 cagtatcaag actatctgtc gctatcttta ggcactgttg accttcttga tgtgcttttt
    45301 caagaacgtt ttgtcttaac tgtgttatat cattcaccta atttccccct tttgatagtg
    45361 ttagtggtat caccgttttt taaaatctag ataaggaccg ttaccttatc caattttatt
    45421 taagagaata aaggagacga caaaggcaag aatagcatag gtttcaacca tagctgctag
    45481 aatgacaccc ttcataaaat ctttagggcg cttagccaag atttgcatac cagctacaga
    45541 aacattgcct tggtgcttgg ccgaaaaata accaacaata gcaattggaa gagataccaa
    45601 aaagtaagct aatccttggt taactgaaag ttctggtgtc agtttcatcc aaattaaaat
    45661 accaatagca aagccgtaga ttccttgact accgggtaac agttgcaaga taagcgcaga
    45721 cgtaaatttt tcgggttctt cttttaagag cgcagctgcc gcttgaccac ctttaccgac
    45781 accataagct gagcccatgc cactaagagc tacggctaaa acaattccta aggctgcgaa
    45841 gaaaacgcca ccatgtgctg taaaataatg tgctaaatgt tccatgttaa ttgtcctcca
    45901 aatctgtttc ttcattgaca ttgacataat tatcagctaa ctttaaagga ttgaaagctt
    45961 ttcctccacc ttcataaaat tttccaaaaa actctacgaa aataagacga gcaccatgca
    46021 catatcctga aagcattgat aagaaaatat tgatcgcatg caaaagaata aaaataaaga
    46081 tacctactgt aaagcgcgtg actggtggaa aaatcccaac aatcatgtta aaagccgctc
    46141 caatactagc tccagaaagc cctaatgcca ttagacgagt aaagctaacc aaatcactta
    46201 agtaagagct aatgccatat aaattatata atccactacc tagacctaaa aggcttttgc
    46261 tttttagtaa agaaacaacc aaaatcccaa aggcattgcc caatgcaagc cacttaccaa
    46321 taaccgataa gtaagcaagg ccagatacat tcttaccaag aataaataac agcaggccta
    46381 ataaaataaa agtccaagct agacttgacg tataggccgt agcatatgct ttcatcctta
    46441 cttgttgcca tgctcctaac aaaagcccaa atataagtgt aacaaaccca aatagcaaag
    46501 aaacaaccaa aatagtaatc acatccgttt tagttgataa taatgccaca ggtaagtcaa
    46561 aaccaaagaa agaaccgtaa ataagccccc atatggctac tgaaatagct aaaatattaa
    46621 agaaggtcac taaccgttta ctggtttttt ggagattaaa aaagaccaat gcagctagtg
    46681 tcacagcata tagcaacaaa ccatagccca aatcagctac catcatgcca aaaaaagtaa
    46741 ggtataaagg agctaaaaaa ggtgtcggat ctttttcttg atattttggc aaagcgtaca
    46801 tttctgtaac caattcaaac ggtgcaatgt agcggtgatt acgtaactta atgggaacat
    46861 cttcccaatc gtctggcgtg acatcgtaac tatccagata aaacatatca cctagtgtct
    46921 tagtcattag cccttttaat tggttaaccg aatcagcttc tatccaccct tctaaggcta
    46981 ttagatgtct tgtaccgagt aattgctttt tagtttgctg ccgttgatac tgactaagga
    47041 catagtctat ttcaacctgt aactgtgcca gtatcttttg agactgccta agctctttta
    47101 gtagactatc tttttcagct agccaattcg ttagtaactc tttgtttata cgaagttgtt
    47161 ctgatggcag tagctgttct ttatataata agggtttaaa ctgatatttc tgtaaatgaa
    47221 tcgtatcttg tgcttgccaa aataagacaa gaccgtactc aaattctgta tggtatactt
    47281 cctcaataaa aagacctttg tgctgcttta gctgatgata aaaatgatca tttgctgtac
    47341 taggaatcgt tccaactctt gccgacaaaa aatgaaattg cgctaaatcc tgaggcaaaa
    47401 cagtcaagga acgccacttt tctaactcct gacagtattc tgttagctgg tctattttgt
    47461 tttgcagctg ctctagtcgc tctatctttt gtgacatcat tttcaaagcc gtttgagctg
    47521 cttgttgtcg atggctttct tcgaactgtt taaacgaaag agatggcgtt ttttgtctca
    47581 aggctgttaa ctttcctatt ggtggtaaaa acgctgataa gctagcaagg ccattttcta
    47641 actcttgttg gctttgtaaa aggtattgta aagcttcatc atctagtaga ggtttttgat
    47701 gcgtcagatc gtattggacg atttgtggca acttgacgtt gcctttgtta aaagcatctt
    47761 gccaatgttt tagttgcttc atgtcacgaa cttcaactaa ttgagattgt tgaagtgttt
    47821 ttaaaacaag atcaagataa tctttttcaa aaaccattgc cagctttttc atttgactaa
    47881 tggccatatg tctccaccac cttatccact aactccctaa caacggttag cttatgctct
    47941 tctaaaatgg catgaagggc tagctgttgc gtcgctaacc tcttttttga agctttttgt
    48001 tcttgacgat tagcttcaaa aaacacctca cgtttagctt ctaatagtag ctgagtttct
    48061 tgttcgtact caaggaacag ctgctttaac tcttcttctt ttttgtcagc tagagctttt
    48121 ttcttagcat cgtaactgtc ataaattgtt ctagcctctt gttcgatact attcattagt
    48181 gacaataggg tattcatcac atatcaactc cttatcttta tctattgcta attctttgac
    48241 tcactaggta cttaaaaaca aagctacaag aaaggctact tttgggggtt aatcaaccag
    48301 cgactataag ctagagctaa atctctaacc tatctactaa cagctttttt gagataggat
    48361 aattgcttga ttaaacgaac agcatcttta agttaagcgc tttcaatttt atccataaaa
    48421 acaatggctt agttcagaaa aaggttagct aaaaacctgt caaagcagta agatgacaca
    48481 gaactctaaa gctttgtatt gctgtctttc gtgtgttatc ttatacttct ttaggcattt
    48541 agtaaccttg atctagttga cggtaaggta cctttaccag ccaatagcca agccaatgtg
    48601 ataacagtat aactgctatc ttgttaaaag tcctgtcaaa aagatgttta ttagtttctc
    48661 gcttgtaatt cttgttttgt tactaaacgg taatttttaa agacagaacc tccaatataa
    48721 cccacaatta agctgataat aatacatcca agggctgtta tcaacacttt agcgacagga
    48781 ttataggcaa acatcaccgc aaaaccggca atcggagtag ctgtccctgg cgtatcatta
    48841 accaatttca ttagggcgat caaaacacca catgcagcac caccaacaaa attagtcaca
    48901 taaatcggaa tgggattggc tgacgtcaca tctgcctgcg ttagtggttc aatagcaaaa
    48961 gcaatattgt cttttctttc acccaatttt aatcggtaaa aaagaacacc attcataaaa
    49021 gaagagccaa agacagataa ggcacctata gccatcggaa tacctgtcag accaagcatg
    49081 gctgtcaaag ccattgatga tagcggagct gttgctacaa caacaatcgt accgcctagt
    49141 atcattccca tgataatagg gttgctatta gcacttgagg tcaggatgtc tccaatagtt
    49201 aataaagtac tattgatcac tggcgtaatt aactgcgcca agaaacgagt taatggtgca
    49261 ccgacaataa taatcgagat taaatcaagc ccaccaggaa tatttttttc catccacttg
    49321 attaaaaaag ataccacata cccagccaca aaacctggga taatacctgt ccctgaaact
    49381 gacaaaccaa tcaaaacggc ataacctgga gacacaccaa ttgcaatggc aaccaagata
    49441 gcagcagcta cccctgataa tgagccattt gctccgccta cttcacttag aaactgaaag
    49501 cctaaaacct taccaaaaaa agaatcttga aaggcttcaa ctaaaaaaga ggcacaagct
    49561 gccgaagcca aagctcccat tgccttggca ccatgaggag ccttatagtt aaacaagcta
    49621 aaaatagcta aaacaagaat caaaagactt gttccaataa taatatccat aatctattcc
    49681 accaatctat ctcattacat aagacactat aactgcttca ctctggcaac agcttcgact
    49741 tcaatcaaag cttgcaaagg aagcgccgac acttgaaccg ctgtccgaac agggtaaggc
    49801 tcttcaaaca aatcagtcat gacatgattt aatatttcca cattggtcac atctgttaaa
    49861 tacacattta gcttatagat atgattcaag tccaactttt gctctgccaa aatagattgt
    49921 aaattaacaa aaacctggcg acactgtgcc tcaaaaccat ctgacaattg acctgtcact
    49981 ggattaaggg gtaattggcc tgcggtgtat agaaaatgtc cttcaatcgt ataagttgaa
    50041 taagggccca ttggttctgg gtagctcttc atatacgaac ctcctcattg ataatatagt
    50101 taaattttac aggaaaccgc attcacagtc aataataaat tctctttttg ataaaaaatt
    50161 attattaagg tgattggcaa ttgtttttta gtctaaaatg tattactata tttgtaaata
    50221 agaagataga tataggaagt ttgacatgga taaagaaaca ctaaactact ggaaaacggt
    50281 tatcacattt cttcacgatg tcttaggtga taactatgaa attattttac atgtgattga
    50341 taaaaatgat atctatattg gagaactcgt taatagtcat atcagtggac ggtctaaaca
    50401 gtctcctctc accacctttg ctcttgattt gattaccaat aaagtctata aggaaaaaga
    50461 ttttgtgacc aattacaaag caatcgttag tcctcagcac aaagaagttc ggggatctac
    50521 tttttttatt aaagataaaa agggtaatct cgagggaatg ctatgtatta acttagatat
    50581 ttcagcctat caaggagtag ctagggacct cttaaaactt gtcaatctta atttagaaca
    50641 tttcatccca actgctaaag agcctaaaac agtcacaccc cagccagaag aagctgttga
    50701 aattttaacc tctaacatcc aagatattat cggtcaaatt attgatccct cgttactgag
    50761 acacaatgta catcttagcc aagatgtcaa aatagacatt gttgccaagc tttatgaaaa
    50821 aggagtcttt caactaaaag gagccgtctc aaaagtcgct gatattctat gtatttccga
    50881 accaagtgtt taccgctacc ttaaaaaaat tgaagccgat caataactaa atcaccataa
    50941 aacgccagtt aaaagtattt cagataagca tcacaatctc tgatataccg atgactgacg
    51001 ttttttttac tcaatatgcc tttatggcaa gaaaaggcta ctggtcatta accttcagct
    51061 atgcttagag gtacacctgt cgcagcttga acctcatcaa aagtaaaccc ttcactgatt
    51121 tcaattactt ggataccatc tggcgttact ttaaacacac ccatttctgt gataataagg
    51181 tcaaccacac cttttgctgt taaaggtaag gtacattctt ttaggagctt atgctttcct
    51241 ttattggtat gctccatagc tacgatgact tttttagcac caactaataa atccatcgct
    51301 cctcccatac caggaaccat tttgcctgga atcaggtaat tggcgatatc tccattttct
    51361 gcaatttcta aagcacccaa gacggtcaag tcaacatgac caccacgtat aatgccaaaa
    51421 gaatctgcac tattaaagaa agcggctcct ggataaaccg tcacaggctg tcctcctgca
    51481 ttaacgatag tcgaattcgg atcatctgac ttaggaccta gtccaataaa cccattttca
    51541 gattgaaaat acactgtcat ttcttcaggc acaaaatttg ctactttggt tggtagacca
    51601 atacctaaat ttaccaaagt accatcttct aattctttgg ccacacgctt tgcaatacga
    51661 ttttgaatct cttctttact taatgcaacc gccataacta tactccttct ttaacaatgt
    51721 aatctacaaa aatgtgtggt gtatgaacgc attctggttg tatagtgccg actggtacta
    51781 tttctcgcgc ctgaacaatt gttgtttttg cacaagctgc catcaattga ttaaaattat
    51841 tttcagaacc actatactgt aaatttccca tttcatcagc tttattagca aatatcaagg
    51901 cgacatctgc ttcaaatggg tattctaaga gataggtttt tcccttgatg gtttttgttt
    51961 ccttgccttc tgccactaag gttcctaccc ctgttggcgt gtaaaagcca ccaatgccat
    52021 aagctccgat gcgaattttt tcggcgaagg ttccttgagg aatgagctca atcgtcgttt
    52081 caccggcagt catttggcgc ccagcttctt tatttaatcc aatatgtgtt gcataaatgg
    52141 ttttgaattg atgattagcc accatttttc caacaccgcg atcaacaaaa ccagcatcat
    52201 tacagatcaa ggttaagtct tttgtgcctt tgtcaaccag tgcatcaatt aacgcttctg
    52261 gtgttccatt agccataaaa ccaccgacca taatcgtgtc accatcttta atatgactga
    52321 tagcttctgc tattgctatt cttttattct ctttcatacg gttaccttct atcttgttac
    52381 gatgatactt tgaccttggc caccaccaat acaaagcgtt gctaagccat gtctcacatc
    52441 acgcttagcc atttctgcta ataaggtgac taaaatacga gcacctgatg ctccaatcgg
    52501 gtgacccaaa gcaatagctc ctccattgac attaactttt tcattgtcaa aaccaaggtc
    52561 tcgtgaaacc gctaaagcct gagcagcaaa agcttcgttt gcttcaatca aatcaatgtc
    52621 atcaattgtc agctgagcct ttgcaagagc ctttttcgta gcaggtattg gtccgcagcc
    52681 cataatactt gggtctacac ctgcacttgc ataactagtg attttagcta aaatagggag
    52741 ccctaattct tcagcttttt ctttactcat caataaaatt gctgctgctc catcattgat
    52801 tcctgaagca ttaccagcag ttactgtccc ctcatctttg ataaaagcag ggcgtaactt
    52861 tgctaactta tccactgtcg ttccaaattt agggtattca tcttgatcaa cgagtaaagg
    52921 ttcaccttta cgctgaggaa tagtgacagg tgcaatctct tctttgaaac gacctttttc
    52981 tatggcaagt tgggctttac gttggctatc agctgcaaag gcatcttgtt cttctctggt
    53041 cagtccatac tgttgcacaa tattttcggc tgttataccc atgtgataac ctgcaaaagc
    53101 atcactcaac ccatctttaa gcatggtatc tactacttta ctatctccca tacgagatcc
    53161 ccaacgttgg ccttgtaaaa cgtaaggtgc ttgactcatg ttttcggtac caccaactaa
    53221 aacaatatca gcgttgcccg tttgaatctt ttgagcacct aactcaactg cttttaagcc
    53281 agaaccacag accatatcaa tcgtaaaagc aggggtatca taagaaagcc ccgcatttag
    53341 cgctacttgc cgagcaacat tttgacccag acctgcatgt aacacattcc caaagatcac
    53401 ttcatcaatg gcatcacttt taagaccggt atcagctaaa atttttgtaa caactgtcac
    53461 ccccaaatct acggctgata aagatttaaa gactcctcca aaatttccta tcggggtacg
    53521 ataagcagat gtgatcacca cttctttagt catagaaact tctccttttt cattattgaa
    53581 acgcttacat ttttattata taatgtgaac tataataaac aaatatcgtt tttttatata
    53641 tgctataact aaacgttatc gaaagaggaa aatatgaata tctcgagctt ggcttatttt
    53701 attgagattg ttaattgtga ctttaactta accaaagcag cccaaaaaag tcatatttcg
    53761 caacccgccc ttagtagtta tatcaagact atcgaaaaag aagaaggagt cgttttattc
    53821 cagcgtcaaa aagggcgtct agttggacta acctcagtcg gcgaacgctt ttttgaaaat
    53881 gctaaggtgg ttatcgcatc acatgagcaa ttaatggctg atttgcggag tgaatccaaa
    53941 aaatacaaag gagaaatttc aatcggtatt cctcaactca tctctggcat tgttttttct
    54001 gagctcattc caaaactcat cgaagaaaat cccgaagtta aatttcatat tgtagaaacg
    54061 ggtgcttatg aactgcaaaa aaaactgttt ctaaaagaag tcgattttgc gattttatta
    54121 acacccacta cactagatgc tactattgct gatatcgaca ttctcctaag agatcaactc
    54181 tgcctttata tgagtcacaa aacctttcaa gagacgtttg atagtaatcc taacatctct
    54241 atcaaagcat tacatcgtca aaacttagta acttttgata aaacctttat gattaatcat
    54301 cagcttacca ccttatttga agaagcaaat agtcttcctg tagtcaaatg ttattctgcc
    54361 tcgtgggatt ttttattaaa ttgcacgcgc tattcctctt acctaacaat cctaccaaga
    54421 cctattactc attttgctca tatggacggt ttagtggagg tccaactgac cgaacatcca
    54481 aaatgggaag ttgttctagc ctctctcaag cacaataaaa caagccattt aaaacattat
    54541 atcaagcaca ccatcttaga ttatttcacg aatcagcgct tctaattgct tgactcagac
    54601 cttaaaaaaa cgcctgaagg aaacaatccc aagcgtttca tatagttatt tcctaaaata
    54661 caaataggta aatgatggca atacctgtga ccaccaagac acaaggaata gtataagcca
    54721 caatttgatt gaattttagt ttgaagtttg agagataaga taaggcccaa aaaggaacta
    54781 tcaagtttgt tgtggcatct cctaattgat aagcctgcaa aatcttacct aggtcattac
    54841 caacttcgat ggttgcaggg acgatatagg gagcttcaat cacaaatttt gagcctcctg
    54901 atggtaccgc aatattcagc aaagccgagt aaagataagc aaagaccggc catgttgtcc
    54961 catttgaaat agcgacaaag aaatgggaaa tctctagtcc tagacctgta ctttgaatga
    55021 ttccaaaaat accagcgtaa aatggaaact gaagcaccaa gccccaagat gacatgaccc
    55081 catctttgaa taaggaacca taatattctg gtccttgttg accacaaaga agcaacccta
    55141 agcctaaaaa taaaaagtta aaactattga gatctagacc agacaagccc accaccgaaa
    55201 aatgataaag gctatagcta acaatggccc caccaacaag atacatcact aagcgagatg
    55261 cgttcatctt ttcagcaggt gtgtttcttg caataacaac atgtgaagcg gtatcaagac
    55321 tatggtgata gatctcatca tcaagttcca tgattttagt ttcatctttt ggatgcgcca
    55381 ataaagtaaa gcaaagcggt accagcatac acaccactaa aagactgata aatggaagat
    55441 tcaaaactga ttctgtcaga ggaacacttt caggaacaac ctgtttataa gcatctgcga
    55501 cactatttcg caaataatct ggagtagccg aataaagcac cgcagcacca gataaaccag
    55561 aagtagctgg taaaaaggta aaaaataaag tagcaacaaa caaaggtgta tgcaccttaa
    55621 tccctttttg cctagcctga acaagcaact ctttcccaaa cacaatggca accatcatac
    55681 caagacccca gtgtaaaaag ccaaagatag agcctactac aagagaaaaa ataaaaatct
    55741 gagtcctggt ttgaggcagt ttggcaaggg acttaaacat cttatgagca ggtggagaac
    55801 tcgctacagc attccctgtc gcaagtaaaa tagtcatctg catggcaaag gacaacagcc
    55861 cccaaaaacc atttacccag ccatagataa tcccgcccgt cttttccgta ccaataaagg
    55921 gactatccgt catcaacaca gacatagtaa cgactaaaaa ggttaaaata aaacagataa
    55981 aaagcgattc tggcatccat ttcataaagc catcaatata gcgatccata aacctttttt
    56041 tggttttgat gttattcatg ttgtcaattc ctttcacgtt gtccaaaagc acttttgttc
    56101 ttttgatcag taacctgtcg ataatactaa taagcgtttc tttagttcat ttagttatca
    56161 ataagtttaa acccacaaaa aacacttttg ttcccttttt attatgacaa cgttttcata
    56221 aataaacaac tatgattttt ttattgcttc cataaccctt atttatagca aaaagaatgg
    56281 cgcttca
//
LOCUS       DAUDWO010000007        53946 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.007, whole genome shotgun sequence.
ACCESSION   DAUDWO010000007 DAUDWO010000000
VERSION     DAUDWO010000007.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 53946)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 53946)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..53946
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.007"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(293..694)
                     /locus_tag="VHC05_000377"
                     /pseudo
     CDS             complement(293..694)
                     /locus_tag="VHC05_000377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558053.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            complement(1117..1650)
                     /locus_tag="VHC05_000378"
     CDS             complement(1117..1650)
                     /locus_tag="VHC05_000378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002949762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF402 domain-containing protein"
                     /protein_id="HEQ5401720.1"
                     /translation="MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENALIGVNDH
                     TLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGVSYYCNLASPYMMDTEALKYI
                     DYDLDVKVFADGEKRLLDVDEYEIHKKEMQYSADMDFILKENVKILVDWINHEKGPFS
                     KAYITIWYKRYLELKNR"
     gene            complement(1730..2506)
                     /gene="recX"
                     /locus_tag="VHC05_000379"
     CDS             complement(1730..2506)
                     /gene="recX"
                     /locus_tag="VHC05_000379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination regulator RecX"
                     /protein_id="HEQ5401721.1"
                     /translation="MKITKIEKKKRLYLIELDNDESLYVTEDTIVRFMLSKDKVLDND
                     QLEDMKHFAQLSYGKNLALYFLSFQQRSNKQVADYLRKHEIEEHIIPDIITQLQEEQW
                     IDDTKLADTYIRQNQLNGDKGPQVLKQKLLQKGIASHDIDPILSQTDFSQLAQKVSQK
                     LFDKYQEKLPPKALKDKITQALLTKGFSYDLAKHSLNHLNFDQDNQEIENLLDKELDK
                     QYRKLSRKYDGYTLKQKLYQALYRKGYNSDDINCKLRNYL"
     gene            2621..3976
                     /gene="rlmD"
                     /locus_tag="VHC05_000380"
     CDS             2621..3976
                     /gene="rlmD"
                     /locus_tag="VHC05_000380"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HEQ5401722.1"
                     /translation="MVVKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIFC
                     QITSVKRNFAEAKLLMVNKASKNRVKPACSVYETCGGCQIMHLAYPKQLDFKDDVIRQ
                     ALKKFKPTGYEQFEIRPTLGMKKPDHYRAKLQFQLRSFGGTVKAGLFSQGSHRLVPID
                     NCLVQDQLTQDIINKITQLVDKYKLPIYNERKIAGIRTIMVRKAQASDQVQIIVVSSK
                     EVRLARFIGELTKAFPQVKTVALNSNRSKSSEIYGDETEILWGQEAIHEEVLDYGFAL
                     SPRAFYQLNPQQTEVLYGEVVKALDVGSKDHIIDAYCGVGSIGFTFAGKVKSVRGMDI
                     IPEAIEDAQKNAKAMGFDNAYYEAGKAEDIIPKWYKQGYRADAIIVDPPRTGLDDKLL
                     KTILHYQPKQMVYVSCNTSTLARDLVQLTKIYDVHYIQSVDMFPHTARTEAVVKLQKR
                     V"
     gene            4641..5996
                     /gene="rocA"
                     /locus_tag="VHC05_000381"
     CDS             4641..5996
                     /gene="rocA"
                     /locus_tag="VHC05_000381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator RocA"
                     /protein_id="HEQ5401723.1"
                     /translation="MLEDFLQFLGFIFLDIIEIMLTLKLFSFVSAIPLRLKNIFYLSL
                     SMVLFQVVFWAFFPDHFILDVVMLAQFLFFALIALYYGKSIKAKFLMFYAFFPLVSIS
                     LVKRFIVFFVMPLFGMPYSVVKHNTLLIYSITCFSIFLIYRCIQVFHFDFSTWRQYFQ
                     SHRASKLLVFTNSSMALYYLCIQGIDVMSPSLSGLATTTARSIIVLFYFILFLTLLIH
                     LERYVKQNSIEAIVQQKEYRELINYSQHLGLLYQDIQELRQLLTTVSSRLKIGIEQND
                     ISIVRLTYEGILNAEKNNAKDDRLDLTCLDKLQVEAIRHIVLAKLIEAKNKKLKVEVS
                     IPNCIATFFLEVVDFTKLLSFLLDNAIEMSLETKQPCLSIAFLDQNHKLVIVIQSSTK
                     QGQNDSQSVFATPALKKRDDWQFDLRNVTTILNRYDYLTISSQIHDGILTQLIEIAKP
                     D"
     gene            complement(6097..8802)
                     /locus_tag="VHC05_000382"
     CDS             complement(6097..8802)
                     /locus_tag="VHC05_000382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HEQ5401724.1"
                     /translation="MATKKVHIISHSHWDREWYMAYEQHHMRLINLIDDLLEVFQTDP
                     DFHSFHLDGQTIILDDYLQVRPEREPEIRQAIASGKLRIGPFYILQDDFLTSSESNVR
                     NMLIGKEDCDRWGASVPLGYFPDTFGNMGQTPQLMLKAGLQAAAFGRGIRPTGFNNQV
                     DTSEKYSSQFSEISWQGPDNSRILGLLFANWYSNGNEIPTTEAEARLFWDKKLADAER
                     FASTKHLLMMNGCDHQPVQLDVTKAIALANQLYPDYEFVHSCFEDYLSDLANDLPDNL
                     STVQGEITSQETDGWYTLANTASARIYLKQANTRVSRQLENITEPLAAMAYEVTSTYP
                     HDQLRYAWKTLTQNHPHDSICGCSVDSVHREMMNRFEKAYEVGHYLAKEAAQQIAGAV
                     NTSDFPTDSQPFLLFNTSGHSKTSVTELTLTWKKYYFGQRFPKEVYQEAQEYLAGLSQ
                     SFQVIDVSGNTISEADILDTSIAFDYDLPKRTFREPYFAIKVRLRLPITLPAMSWKAL
                     ALQLGNETAPSATVPLYDDSNQCLENEFLKVMIQTDGRLTITDKQSGVSYQDLLRFED
                     CGDIGNEYISRQPTHDQPFYADQGTTKLNIISNTAQVAELEIQQTFAIPISADKLLQA
                     EMEAVIDITERQARRSQEKAELTLTTLIRMEKNNPRLQFTTSFDNQMTNHRLRVLFPT
                     HLKTDHHLADSIFETVKRPNHPDATFWKNPSNPQHQECFVSLFDGENGVTIGNYGLNE
                     YEILPDTNTIAITLLRSVGEMGDWGYFPTPEAQCLGKHSLSYSFESITKQTQFASYWR
                     AQEGQVPILVEQTSHHKGSLRAEHSYVTGADDQVALTAFKRRPSDNALITRSYNLSND
                     KTCDFSLSLPNYNAKVTNLLEKDSKQSTPSQLGKAEILTLAWKKQ"
     gene            complement(8817..10103)
                     /locus_tag="VHC05_000383"
     CDS             complement(8817..10103)
                     /locus_tag="VHC05_000383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 125 protein"
                     /protein_id="HEQ5401725.1"
                     /translation="MTRPIPTSVSQFMAKVESLCGDQHPDWALNFKTSFTNTLETTLK
                     TYEDGTSFLLTGDIPAMWLRDSTAQIKPYLFLAKEDEEIRKIIAGLVKRQFRYICIDP
                     YANAFNEEANGKGHQTDRTQMNPWIWERKYEIDSLCYPIQLAYLLYRETGSTDQFNDD
                     FHRGVELILDLWTVEQDHAQSPYLFERDTWRKEDTLTHKGKGSPVAPTGMTWSGFRPS
                     DDACQYGYLIPSNMFAVVVLSYLEDLYNNLFHNESVATRAKQLKEAIQSGIADHALVQ
                     NSKGETIYAYEVDGLGQFSIMDDANIPSLLAAPYLGFCAKDDPIYLATRRTILSQENP
                     YYYQGNAAAGIGSSHTPENYIWHIALALQGLTALDQDSKKEMLDLLVATDAGTHLMHE
                     GFDVNDPYQYTREWFSWANMMFCELLLDYLGFSITP"
     gene            10236..11276
                     /locus_tag="VHC05_000384"
     CDS             10236..11276
                     /locus_tag="VHC05_000384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEQ5401726.1"
                     /translation="MTKLLYKKIYHFIKEQIASGRLQIGDRLPTEKELSEQFSVSRIT
                     SKRALVELEQEGLITRSRGKGSFVAKKQVTSPEANKDLLLILPFASDYELGDYAKGIM
                     TSIAETGYRLMVQLASTVRLDTLSDYAGIIYYPEDVNHSIDFLFYCDHHHIPLVLLDK
                     SLDLFQFPSVVADNKGGACQLTQHLIEQGCDQISFVATGSFGEVSSVRDRYLGYLAAM
                     AESSLKSHYFPKTETETTDAYLDRLVKTLSETTATKRGLVVENDWLAIQLIQKITQVG
                     LSIPDQVAIVGFDNSQASRLLSPKLSTAAQDFYQMGQEAAKVLLQIIHEPDQAVVSCQ
                     LPVQVFIRESSH"
     gene            11327..13021
                     /locus_tag="VHC05_000385"
     CDS             11327..13021
                     /locus_tag="VHC05_000385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylglucosaminidase"
                     /protein_id="HEQ5401727.1"
                     /translation="MTIYHTLKDYQEVMTRGDYLVFDTPLTCRFIGRFFRFENQKALL
                     AELATSKYFQWIEEGQAEVTMKHFFNRQLAKDAFTLKVSEDKEIIIESQNLRGFRYAQ
                     EALLKVMTFKGDKLYLPIVSVKHSPSFAMRGIIEGFYGTPWTREERLDCLRFIGNKRM
                     NTYMYAPKDDDYQRKQWRDLYPEDWVTYFKELLAVAKEEGIDFWYMISPGLDFDYTKE
                     ADYQLLYQKLQQLLALGVCHFGLLLDDIDYQIVDAVERRFKKTAYAQAHLATEVHHFL
                     NQQHAAPELVICPTEYDNHHDSIYLQELSERIPKEVAFFWTGPSTLASQISQADIETM
                     AAIYQRPIIIWDNIPVNDYQKDPERLFLTPFANRSPFLCQPDYQVKGIVSNPMISWEL
                     SKLTLTDMSHYLWDANRYQPSHSWLETLTDYTEDTELALALQAFAWHNGNRHLHRDLP
                     FEVEEALLAKNVSTLSAWVDELVELVNTLRKLDKPAFQQAIAPWFERVAKDQDFWQAM
                     LNQEPQLETLYADLQEDKHRIGSDIPSRYYRIYYQQQDKLTANQGQVTQARPEDYA"
     gene            13046..14488
                     /locus_tag="VHC05_000386"
     CDS             13046..14488
                     /locus_tag="VHC05_000386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HEQ5401728.1"
                     /translation="MLAFPKDFWWGGATSGPQSEGRFAKQHRNLFDYWYEQEPTLFYD
                     YVGPDTASDAYHQIESDLTLLASLGHNSYRTSIQWTRLIDDFEQATINPDGLAYYNRV
                     IDACLANGIRPVINLHHFDLPIALYQVYGGWESKHVVDLFVAFSKVCFEQFGDRVKDW
                     FVHNEPMVVVEGSYLMQFHYPAIVDGKKAVQVAYNLALATAKVIQAYRRGPAELSDGR
                     IGTILNLTPAYPASQSEADTAAAHFAELWNNDLFMEAAVHGKFPEELVAVLKKDGVLW
                     QSTPEELALIAENRVDYLGLNFYHPKRVKAPDVIPVISPSWSPEWYYDAYLMPGRRMN
                     VDKGWEIYPEAVYDIAVKMRDHYDNIPWFLSENGVGISGEDRYRDETGQIQDDYRIRF
                     LKEHLTYLHKGIEAGSNCFGYHVWTPIDGWSWLNAYKNRYGLVENNIHTQVRRPKASA
                     YWFKKVATHNCLISLKVMEEFGGSASHLSD"
     gene            complement(15099..15977)
                     /locus_tag="VHC05_000387"
     CDS             complement(15099..15977)
                     /locus_tag="VHC05_000387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEQ5401729.1"
                     /translation="MSLLCLDIGGTSLKFALCHNGQLSQQSSFPTPSSLEKFYQLLDQ
                     EVARYSAYHFSGIAVSAPGAVNKEKGIIEGASAIPYIHHFKIQEALEERLHYPISIEN
                     DANCAALAEATLGAGKGASSLAMLVLGTGVGGSLVIDGKIYHGAHLFGGEFGFMIMND
                     RYQTFSQLGTVVNMAKRYSAIVNNGKDYTGKAVLALAEQGDHLAIKERQVFLQSLAIG
                     IFNIQHAFDPQLILIGGGVSQADFLLSAIEAELDKLYQAVEISDLRPQLAICHFKNEA
                     NLLGAAIDFYQEHKEA"
     gene            16194..17144
                     /locus_tag="VHC05_000388"
     CDS             16194..17144
                     /locus_tag="VHC05_000388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004219264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEQ5401730.1"
                     /translation="MTRQTNKKTSFWKNVIKYRALLLMVLPGFIWFIFFFYIPVLANV
                     VAFKDFHYSAGGFMESLKESPWVGLANFKYLFASKDAWLITRNTIAYNVIFLLFNVFF
                     AIAFAIIMSELRNKRTVKVYHTMSLLPYFLSWVVIEYFVSAFLNTDKGFINQLLTGSG
                     GAPIKWYSNPTWWPLILLFMSVWKGLGYNSIIYYASVKGISDTYYEAAMVDGASKWQQ
                     IRNITIPQLLPMMSILLIINIGNIFKSDFGLFYVIPKNSGPLYDVTSVLDTYVYNALT
                     ATGDIGMASAASLYQSVVGTSILLVTNAIVRRMDPDASLF"
     gene            17154..18080
                     /locus_tag="VHC05_000389"
     CDS             17154..18080
                     /locus_tag="VHC05_000389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEQ5401731.1"
                     /translation="MEKKKKVEKVNVRTFDRKTNAIFNILIGLFAISCIIPFIFVIII
                     SFTDESYLINHGYSFFPDVWSTKAYQYIFQGAMSHRIMRSFGISVFITVVGTFINTTM
                     TSTYAYAISRPYFPYRRFFTVYALITMLFAPGMVANYLVVSNLLHLKDTVWALILPMA
                     LGPFGILVMRTFFKKTVPDSIIESARMDGASEWMIFMKIVLPLAVPGIATISLFSALT
                     YWNDWFNALLYVQSENLYPMQYLLMKIQSNLQALAQNAGMSAQMADSLASLPKESVRM
                     AIVVIATLPIALTYPFFQKYFVGGLTIGGVKE"
     gene            18161..19606
                     /locus_tag="VHC05_000390"
     CDS             18161..19606
                     /locus_tag="VHC05_000390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEQ5401732.1"
                     /translation="MKKWQKIVCVTGTVLAASSLAACESKSASKDSDVKLLMYQVGDK
                     PDNFDELMTIANKRIKEKTGATVDLQYIGWGDWDDKMSTIIASGENYDIAFANNYVVN
                     AQKGAFADLTTLMPKYAKKTYKNLDPAYIKGNTIDGKLYAFPVDANVYAQQMLSFNKE
                     LVDKYGLDISNIKSYADAENVLKQFHEKEPNTAAFAIGQVFSMSGDYDYPLTKNQPFA
                     VKIDEGKPTIINQYEDESFKNNLRLMHKWYKEGLIPTDAATNTEGYPLEGNTWFMREE
                     TQGPMDYGDTILTNAAGKDIVSRPLTKPLKTTSQAQMANFVVSSVSKNKEKAVEVLSL
                     LNSDPELLNGLVYGVEGKAWEKIGDKKIKLLDGYQPKMHMGAWNTGNNKILYTQESVT
                     DDMIAKRDQSIKDAKESPILGFTVDTKVIKTELSNISNVMNRYKASINTGTVDPDEAL
                     PKLLADLKGAGWDKVQKEVQKQLDDFVAKDK"
     gene            19912..20517
                     /locus_tag="VHC05_000391"
     CDS             19912..20517
                     /locus_tag="VHC05_000391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HEQ5401733.1"
                     /translation="MNGIEKTCFLIWKMIQLTLIFHLLSLAGLIVFGVGPAWQTIVTL
                     FLKTPQEENHYSLKRAVQLWKSYFKEANLRFGLFALTFLFLTFNLHWAVQFPSLFWFT
                     VSFLIVIAMVWLTMTYLYMVFYAVSYEINLWNNMKLAFISVFLSFKSFLLMLSVLLGI
                     TLMTWQYKGLYLFLTFGALVFCLDFVTKANRRLVDGVIDEC"
     gene            20507..22231
                     /locus_tag="VHC05_000392"
     CDS             20507..22231
                     /locus_tag="VHC05_000392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEQ5401734.1"
                     /translation="MSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLSAIGLSS
                     YSISSTYKRVDAEAQMRLEETLGRLQSQNDITLRVLDQLVGRSEDYHNLYQYMTLTPN
                     QYFSNVFEDWEKGKDTVLFSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADRVIKTGRL
                     LYSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGR
                     KLFHQGGRRFPHLEAEVKKAIKADRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLL
                     AEAVRTVFVYGLVSLLLAWLLLQLLFRVFRNYIQQVSEITDTVEMVAAGDLSLTIDNS
                     HMELELYHISEAINQMLASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYI
                     RMYALSCQQEELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSFA
                     YHVKIDESIADLAIPKFVIQPLVENYFVHGIDYSRHDNALSIKALDETDHFLIQVLDN
                     GRGISQERLADMERRLQEHQTTGNSSIGLQNVYLRLFHHFRDRVSWSMAKEPNGGFII
                     QIRIRKDA"
     gene            22231..23715
                     /locus_tag="VHC05_000393"
     CDS             22231..23715
                     /locus_tag="VHC05_000393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5401735.1"
                     /translation="MYKVLLVDDEYMILQGLTMIIDWQALGFEVVQTARSGKEALAYL
                     TQYPVDVMISDVTMPGMTGLDLIEAAKTYHPQLQTLILSGYQEFSYVQKAMELETKGY
                     LLKPVDKAELQAKMKQFKDCLDAQQAESIRQEAYHDSLLTLWLTDELSEKEFQQLSQG
                     LPAAALTGFTVLYLDCQEWQAAIDAYFEREGQPFYLKKEEDKKVYLAVLLGKTDQAKA
                     FTYDLQKRFSRNMHQLILGETVDDWENVYESYNQVLKSLFYNCEVSPIRAKDKSKIEL
                     PESRLQFFAFNKALMIGDEPTILSKLEAIFDEMKTLNFSPEDVKHVSFLLFSDIYRQF
                     PILDKMTYLSMVKTIHDSQSIDRILRELKKVLDVTNQNNSPEKRYSDLVSETIDCIRK
                     EYHQELTLKAIADRLHVNGVYLGQCFKNETERSFTQYLNHVRIQKAQQLLLYTNQSIN
                     EIAYETGYNTNHYFIKMFKKLNGLSPKEFRDRYKDNYQAIKGDQ"
     gene            23645..27151
                     /locus_tag="VHC05_000394"
     CDS             23645..27151
                     /locus_tag="VHC05_000394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 2 protein"
                     /protein_id="HEQ5401736.1"
                     /translation="MVYRQKSSEIVTRTITKLSRVTSNVKQEIDMTSDSKEQTVTGYQ
                     YHYIDQEGRKQPFNQGWRFLMADVACAQDPSFDDSNWQVIHLPHDFSLTQPYTRNGEA
                     ESAYKLGGVGWYRHYLVLDEVLAGYHVAITFEGSYMETEIYVNGQFIGKHLNGYQEFT
                     YDISDVVTFGAENLLAVRVENKVPSSRWYSGSGLYREVSLSVLPQLHFVADQVAMTLA
                     DTAVQEKGQQKVDLRFALNQSIQTCHYQLSLCLWEQSHCSKDKKLLYQETEVPLADLA
                     FQRQYGLTLSLEELQLWSPDNPHLYDLELTLYYQGQVIDCFCLETGFRQLTFMANQGL
                     FVNGRAVKLKGVCLHHDQGGLGACAYEDALARQLVLLKDMGANTIRSTHNPSSPKLRQ
                     LANRLGFFVIEEAFDTWTYAKNGNVNDFSNYFHQTIGTENANYLQRVRSPETSWAQYS
                     IEAMVWSAKNDPSVLMWSIGNELMEGFSADVSHYPELTRQMCQWIAAIDTSRPITFGD
                     NKLKEADFCWHEEVSQMATFLSQLDHPQGLIGLNYANGKDYDKLHEEHSDWLLYGSET
                     ASAITSRAYYKEPKKVLDSGYHLTSYDHAKVDWGAFASQAWYDTITRDFVAGECVWTG
                     FDYLGEPTPWNKIDSGVVGLWPSPKNAYFGILDTAGFPKDSYYFYQSQWAQGQTTLHL
                     LPVWQKDQLCFDEQGLVEVVVYSNAASVQLMFEDEQGNLTDYGRKAFHTYSTPTGHTY
                     QLYQGADAAKNPHENLYLTWRVPYQKGLLRAVAYDISGKSIPKTSGRSQVRTYGSVAK
                     LSWKAFEAPIDAPWELLYLDLSLLDSRGELVSHAQDWLQVQVEGPARLLALDNGNPTD
                     HTPYQEPLRQAYGGKLLAILALTGEEGHIKVTAKVSQQLSSVFQTQVACRAPKEHLVT
                     LPLEKYQFKKSRLTSQQEIGQSCLKTTQFLSVLENKDTQQKAGKVSTPHILITSYQHY
                     LSLPLQVCSQAFDFKKGDDIFLPQWLQVKDAQGSLVKKAFSMTWYLKEKIFAKPILVT
                     GYVSCFGQSIPVEARLNLAQASKRRHQDLSLVAKQSLTASQKRLTYCYQYDTVQAIGA
                     ISLQNHTDTSLSVSVAISYGSQSSIKQETLMLADSHLSQLEEVIFFDDILTVLYLSVT
                     LEVIEGPDLTEDSIQIGLWDLA"
     gene            27289..28167
                     /locus_tag="VHC05_000395"
     CDS             27289..28167
                     /locus_tag="VHC05_000395"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020905350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HEQ5401737.1"
                     /translation="MSERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAF
                     EVGTEQLADAVQGIRALGIRGSNVSMPNKEAILPLLDDLSPAAELVGAVNTVVNKDGK
                     GHLVGHITDGIGALRALADEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEVRLFNR
                     QATRLSSVQKLVTKLNQLTRTKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENL
                     SLITDPELIRPDLVVFDIVYSPAETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLIT
                     GQDMPVDAIKPLLGDE"
     gene            28419..29174
                     /locus_tag="VHC05_000396"
     CDS             28419..29174
                     /locus_tag="VHC05_000396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HEQ5401738.1"
                     /translation="MVTKEVGHDFLARLGKKRLRPGGVEATNWLIEQGQFSQDCHVLE
                     VACNRCTTAIELAKTFGCQIDAVDLNPKVVKEAQERVAVEGLTRHITVSQANALSLPF
                     PDNHFDIVINEAMLTMLNAQAKEKALNEYWRVLKPGGRLLTHDVAYEDPKTRQVLDEL
                     RQTIHVNVAPLSLTGWQALYQEHGFSQVTYHHGKMSLMTPRGMIKDEGLMNTLNIMRR
                     GLKKENRQQFLKMRRFFTRTGKNLCYIAVKSVK"
     gene            29227..29565
                     /locus_tag="VHC05_000397"
     CDS             29227..29565
                     /locus_tag="VHC05_000397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002265614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HEQ5401739.1"
                     /translation="MSYINNIEHAKVLDLTQEVMIEQDQMLSRTLVQRQDLGITVFSL
                     DKGQEIGRHSSPGDAMVTILSGLAEITIDQETYRVAEGQTIVMPAGIPHALYAVEAFQ
                     MLLVVVKPEA"
     gene            29567..29872
                     /locus_tag="VHC05_000398"
     CDS             29567..29872
                     /locus_tag="VHC05_000398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HEQ5401740.1"
                     /translation="MIENLSQLVQYHDHQVASRSLSRLLGLSQSIVLYAMAQGESISQ
                     ETSPRDKVILVLEGQLIFDLEDQKQVLTQESLIAIPAQKVHHLEAKTDCKLLQVLLD"
     gene            complement(30308..31381)
                     /locus_tag="VHC05_000399"
     CDS             complement(30308..31381)
                     /locus_tag="VHC05_000399"
                     /EC_number="4.2.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-dehydroquinate synthase"
                     /protein_id="HEQ5401741.1"
                     /translation="MPQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQ
                     TVYHLYQTLFEEFAQQYNAFVHVCPPGGQSKSLERVSAIYDQLIAENFSKKDMIVTIG
                     GGVVGDLGGFVAATYYRGIPYIQIPTTLLSQVDSSIGGKVGVHFKSLTNMIGSIYPPE
                     AVIISTTFLETLPQREFSCGISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQS
                     ISNKKRIVEQDEFENGLRMSLNFGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAV
                     SKGLLPKEDLDSLLQVFERYQLPTTLERADVSATSLFDVFKTDKKNSEQHIIFILPTE
                     TGFTTLAINKDDHQFVEKLDSLL"
     gene            complement(31437..32189)
                     /locus_tag="VHC05_000400"
     CDS             complement(31437..32189)
                     /locus_tag="VHC05_000400"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HEQ5401742.1"
                     /translation="MIDIMSDFQNKTCSKNNFIVGPCSIESYDHIRLAASSAKKLGYN
                     YFRGGAYKPRTSAASFQGLGLQGIRYLHEVCQEFGLLSVSEIMSERQLEEAYDYLDVI
                     QVGARNMQNFEFLKTLSHIDKPILFKRGLMATIEEYLGALSYLQDTGKSNIILCERGV
                     RGYDVETRNMLDIMAVPIIQQKTDLPIIVDVSHSTGRRDLLLPAAKIAKAVGANGIMM
                     EVHPDPDHALSDAAQQIDYKQLEQLGQELWQD"
     gene            complement(32431..32501)
                     /locus_tag="VHC05_000401"
     tRNA            complement(32431..32501)
                     /locus_tag="VHC05_000401"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(32467..32469),aa:Thr,seq:ggt)
     gene            32668..32922
                     /locus_tag="VHC05_000402"
     CDS             32668..32922
                     /locus_tag="VHC05_000402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008087830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1912 family protein"
                     /protein_id="HEQ5401743.1"
                     /translation="MSYEKEFLKDFEDWVKTQIQVNQLAMATSQEVAQEDGDERAKDA
                     FIRYESKLDAYEFLLGKFDNYKNGKAFHDIPDELFGARHY"
     gene            32943..33338
                     /locus_tag="VHC05_000403"
     CDS             32943..33338
                     /locus_tag="VHC05_000403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-hairpin-helix domain-containing protein"
                     /protein_id="HEQ5401744.1"
                     /translation="MAKQKNRKKALKLEMKRNGLLKKAGQVFDKAVESVETAVDKTIS
                     AGKNLVEKGSQTVENLTASKERLTLDEFAGQPVVAGIRSDLVETLYAEGIHSAQAFKE
                     WTEKDLLALKGIGPATVKKLVENGASFKK"
     gene            complement(33361..33594)
                     /locus_tag="VHC05_000404"
     CDS             complement(33361..33594)
                     /locus_tag="VHC05_000404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401745.1"
                     /translation="MKPNNPYPAYTGQGRISCYDFRGTTTVSDHKMGLLLFISDFLSS
                     ATSLDICADFSTPPLSVTDQLNAPLIANILTNL"
     gene            33624..33943
                     /locus_tag="VHC05_000405"
                     /pseudo
     CDS             33624..33943
                     /locus_tag="VHC05_000405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002351072.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            33940..34503
                     /locus_tag="VHC05_000406"
     CDS             33940..34503
                     /locus_tag="VHC05_000406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HEQ5401746.1"
                     /translation="MNLIIIGAQASGKMTIGQEVARQTGMTLFHNHDSIDFVLRFMPW
                     SQESTALIERIRFAFFETFAKTGQDMIFTIVIDFNDPNDVAMLEKIQAVFQSYDQEVL
                     FVELKTDIEERLTRNRTENRLKHKPLKRNIEWSEQDIQSTMAYAVFNPEEPPKTLTHY
                     QKINNTHLTAAETAQLIIQKMTHIKEN"
     gene            34505..37153
                     /locus_tag="VHC05_000407"
     CDS             34505..37153
                     /locus_tag="VHC05_000407"
                     /EC_number="6.1.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="valine--tRNA ligase"
                     /protein_id="HEQ5401747.1"
                     /translation="MTELSPKYNPAEVEAGRYQKWLDADVFKPSGDQKAKPYSIVIPP
                     PNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLRGQGI
                     TRYDLGRDKFLDKVWEWKDEYATTIKEQWGKMGLSVDYSRERFTLDEGLSKAVRKVFV
                     DLYKKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALQVATT
                     RPETMFGDVAVAVNPEDPRYKDLIGKHVILPIVNKLIPIVGDEHADPEFGTGVVKITP
                     AHDPNDFEVGQRHNLPQVNVMNDDGTMNELAGDFAGMDRFEARQATVAKLEELGALVN
                     IEKRVHSVGHSERSGAVVEPRLSTQWFVKMDELAKQAMDNQETDDRVDFYPPRFNDTF
                     LQWMENVHDWVISRQLWWGHQIPAWYNAEGEIYVGEEAPEGDGWTQDEDVLDTWFSSA
                     LWPFSTMGWPDTDVEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFQNVLI
                     HGLIRDEEGRKMSKSLGNGIDPMDVIEKYGADSLRWFLSNGSAPGQDVRFSYEKMDAS
                     WNFINKIWNISRYILMNNEGLTLEDAESNVAKVAASEAGNVTDQWILHNLNETIAKVT
                     ENFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEAEKVITRSVLLYTLDKIV
                     RLLHPIMPFVTEEIYAQYAQGSIVTVDYPVVRPAFENEAAHKGVERLKDLIRAVRNAR
                     AEVNVAPSKPITILVKTADSELEDFFTSNVNYIKRFTNPEKLEISSAIAAPELAMTSI
                     ITGAEIYLPLADLLNVEEELARLDKELAKWQKELDMVGKKLGNERFVANAKPEVIQKE
                     KDKQADYQAKYDATQERIAEMQKIKS"
     gene            37307..39306
                     /locus_tag="VHC05_000408"
                     /pseudo
     CDS             37307..39306
                     /locus_tag="VHC05_000408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989028.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endonuclease Cas3''"
     gene            39439..40167
                     /gene="cas5c"
                     /locus_tag="VHC05_000409"
     CDS             39439..40167
                     /gene="cas5c"
                     /locus_tag="VHC05_000409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-C CRISPR-associated protein Cas5"
                     /protein_id="HEQ5401748.1"
                     /translation="MYRSRDFYVRVSGQRALFTNPASKGGSERSSYSVPTRQALNGIV
                     DAIYYKPTFTNIVTEVKVINQIQTELQGVRALLHDYSADLSYVSYLSDVVYLIKFHFV
                     WNEDRKDLNSDRLPAKHEAIMERSIRKGGRRDVFLGTRECLGLVDDISQEEYETTVSY
                     YNGVNIDLGIMFHSFAYPKDKKTPLKSYFTKTVMKNGVITFKAQSECDIVNTLSSYAF
                     KAPEEIKSVNDECMEYDAMEKGEN"
     gene            40167..42062
                     /gene="cas8c"
                     /locus_tag="VHC05_000410"
     CDS             40167..42062
                     /gene="cas8c"
                     /locus_tag="VHC05_000410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017647433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-C CRISPR-associated protein Cas8c/Csd1"
                     /protein_id="HEQ5401749.1"
                     /translation="MDFFTSLLKTYEKAELADLVDHQKRSNEPVLLPIYHTSLKSNGK
                     NIISVKLDKDGQFHKAEFMADKQMIIFPVTADSVARSGSHPAPHPLVDKFAYYSAEMG
                     QSQYDSFHKQLNNWIDYCEEGDVKRFLTIVQQFILKPEFLTLILDSLIAPDYQHNQLK
                     VIYFDATGKEKLIDLSACFLEFSIDQFQGFKNESVSTFKALHQSYISFVEANRENLGI
                     CNISGREEQLTDKHRGLMGNAKIISVSNKREAYKGRFREREDVFSVGYETSEKIHLMI
                     KYLLENKNTSTWLGSSQYLINWFSDDLTNDSRLDIVSPIFDDGLEEDDDDDTPPVITL
                     ATEDNKRIGKSFIKGQKLFANDATYYVAILNKTSNGRIALKYFRQLQASQLLTNLNKW
                     QETYSWESRSKFGKSRLRTPTFHDILNVSYGVDRDRFLELDNDNFKSDQIQKLVASLI
                     DGKPMPQSIVKKLGNNVKERHRYRKHWYQVEQVCLAILHKQNGEEFSPMLDHTNQNRS
                     YLFGRLLAIFELIETLRYGLDGNNNDRITNAERYWTAYTGQPTKLMMLLENKIKPYEE
                     PLKLNRRGSWMKLEKEKEEILELLNPLLETETMEKPLDYRFIFGYYAEKNYYYTKQNT
                     EVTESEE"
     gene            42067..42915
                     /gene="cas7c"
                     /locus_tag="VHC05_000411"
     CDS             42067..42915
                     /gene="cas7c"
                     /locus_tag="VHC05_000411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-C CRISPR-associated protein Cas7/Csd2"
                     /protein_id="HEQ5401750.1"
                     /translation="MLEHKIDFMVTLEVKEANANGDPLNGNMPRTDAKGYGVMSDVSI
                     KRKIRNRLQDMGKSIFVQANERIEDDFRSLERRFSQHFTAKTPDKEIEEKANALWFDV
                     RAFGQVFTYLKKSIGVRGPVSISMAKSLEPIVISSLQITRSTNGMEAKNNSGRSSDTM
                     GTKHFVDYGVYVLEGSINAYFAEKTGFSQEDAEAIKEVLVSLCENDASSARPEGSMRV
                     CEVFWFTHSSKLGNVSSARVFDLLEYHQSIEEKSTYDAYQIHLNQEKLAKYEAKGLTV
                     EILEGL"
     gene            42917..43591
                     /gene="cas4"
                     /locus_tag="VHC05_000412"
     CDS             42917..43591
                     /gene="cas4"
                     /locus_tag="VHC05_000412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated protein Cas4"
                     /protein_id="HEQ5401751.1"
                     /translation="MVYAEDDYLMLSGIQHFQFCKRQWALIHIEQQWLDNEATAHGQV
                     LHTKADNPYIKEKRKELLVSRAMPISSAELGLSGIMDVVEFYKDDQGVSLRGKRGKWL
                     PKVVEYKRGKPKKDTRDIVQLVAQTMCLEETLDCDINEGCLYYHSVNQRVIVPMTSAL
                     RQEVKELAAEMQEVYQSQMLPKAAYFKNCQLCSLVDICKPRLSKKTRSVSRYINEAMT
                     SEEMDL"
     gene            43588..44613
                     /gene="cas1c"
                     /locus_tag="VHC05_000413"
     CDS             43588..44613
                     /gene="cas1c"
                     /locus_tag="VHC05_000413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-C CRISPR-associated endonuclease Cas1"
                     /protein_id="HEQ5401752.1"
                     /translation="MKKLLNTLYLTQEDFYVTKEGDNIVIKQEGKVLKRFPFRIIDGI
                     VCFSYLGVSPALVKLCTENQINLSFHTPQGRFCGRYIGSTNGNVLLRREHYRLSDREE
                     SLEYAKRFILAKISNSRKYLLRFKRDHRQQIDTKLFEAVNDELIWALEMVQAADNKDS
                     LRGIEGQAANQYFRIFNDLVLTDKKTFYFQGRSKRPPLDCVNALLSFGYSLLTFECQS
                     ALEAVGLDSYVGFFHTDRPGCASLALDLVEEFRSYIVDRFVFSLINKGQLQKKHFEVK
                     ENGSILMTENGRAIFIDLWQKRKHTEVEHPFTKEKVKLMLLPYVQAQLLAKAIRGDLE
                     SYPPFMV"
     gene            44624..44917
                     /gene="cas2"
                     /locus_tag="VHC05_000414"
     CDS             44624..44917
                     /gene="cas2"
                     /locus_tag="VHC05_000414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002280569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endonuclease Cas2"
                     /protein_id="HEQ5401753.1"
                     /translation="MMVLVTYDVNTETPAGRKRLRHVAKLCVDYGQRVQNSVFECSVT
                     PAEFVDIKHRLTQIIDEKTDSIRFYLLGKNWQRRVETLGRSDSYDPDKGVLLL"
     repeat_region   45066..45426
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=45066..45097
                     /rpt_unit_seq="gtctcacccttcatgggtgagtggattgaaat"
     gene            45586..46296
                     /gene="ccdA2"
                     /locus_tag="VHC05_000415"
     CDS             45586..46296
                     /gene="ccdA2"
                     /locus_tag="VHC05_000415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HEQ5401754.1"
                     /translation="MTLSLVLMVSVFGAGLLSFFSPCIFPVLPVYLGILLDADDSKTI
                     TIFDKKLYWYGIVKTLAFIFGLSTIFVILGYGAGFLGNILYAVWFRYLLGALVIILGI
                     HQMGLITIKSLQFQKSLTFHNNKNRNGLFNAFILGLTFSFGWTPCVGPVLSSVLALVA
                     SGGNGAWQGGVLMIIYTLGLGIPFLLISFASGIVLKQFNKLKPHMLLLKKVGGVLIIV
                     MGILLMTGTLNNLAQLFG"
     gene            46309..46932
                     /locus_tag="VHC05_000416"
     CDS             46309..46932
                     /locus_tag="VHC05_000416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015017249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlpA family protein disulfide reductase"
                     /protein_id="HEQ5401755.1"
                     /translation="MKKGLLVTTGLACLGLLTACSTQDNMAKKEITQDKMSMAAKKKD
                     EMSTSKDKSMMADKTSDKKMTNDGPMAPDFELKGIDGKTYRLSEFKGKKVYLKFWASW
                     CSICLSTLADTEDLAKMSDKDYVVLTVVSPGHQGEKSEADFTKWFQGTDYKDLPVLLD
                     PDGKLLEAYGVRSYPTEVFIGSDGVLAKKHIGYAKKSDIKKTLKGIH"
     gene            46975..48081
                     /gene="msrB"
                     /locus_tag="VHC05_000417"
     CDS             46975..48081
                     /gene="msrB"
                     /locus_tag="VHC05_000417"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HEQ5401756.1"
                     /translation="MEHKWKLWLFIVGVVLLIGGASVLIQKGQAKAFSQGKPQLPAKK
                     VKSTKVDPNAPVDQKMIYLAGGCFWGVEEYFSQVDGVLDAVSGYANGRGDTTNYQLIH
                     QTGHAETVEVAYDANRISLKELLLHFFRIIDPTSLNKQGNDRGSQYRTGIYYTDKADL
                     AIIDEVFKEKAKDYKKKIVVEKAPLKHFIKAEEYHQDYLKKNPNGYCHIDINQATYPV
                     IDESKYPKPSATEIKAKLSADEYRVTQKNETEKAFSNRYWDSFDAGIYVDVVTGEPLF
                     SSKDKFESGCGWPSFSRPLSPDVVRYKEDKSFNMTRTEVRSRSGNSHLGHAFTDGPKD
                     QGGLRYCINSLSITFIPKADMEAKGYGYLLSSVE"
     gene            48169..48909
                     /locus_tag="VHC05_000418"
     CDS             48169..48909
                     /locus_tag="VHC05_000418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HEQ5401757.1"
                     /translation="MYSLLIVEDEYLIRQGIRSLVDFSQFKIDRVNEAENGQLAWDLF
                     QKEPYDIVLTDINMPKLNGIQLAELIKEHAPQTHLVFLTGYDDFNYALSALKLGADDY
                     LLKPFSKADVEDMLGKLRKKLDLSKKTETIQELVEQPQKEVSAIAMAIHEQLADSDLT
                     LKSLAQQLGFSPNYLSVLIKKELGMPFQDYLVQERLKKAKLLLLTSNLKIYEIAEQVG
                     FEDMNYFSQRFKQLVGVTPSQYKKGGQA"
     gene            48906..50639
                     /locus_tag="VHC05_000419"
     CDS             48906..50639
                     /locus_tag="VHC05_000419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEQ5401758.1"
                     /translation="MKRYPLLVQLISYVFVIVIALITTLGLLYYQTSSRNIRQLIERD
                     TRQSIRQSSQFIDAYIKPLKETISVLAKNSEIKDFASQIHQENDKQVFQLMKMVLATN
                     SDLQAAVLVTKDGRTVSTNPQLIMKTSSDMMAEPWYKAAIDRQAMPILTPARQLSLSS
                     KKEWVVSVTQEVVDAVGHNLGVLRLDIAYPTIKASLDQLQLGRQGFAFIVNDKHEFVY
                     HPKKSVYSSSKEMAAMKPYLAIQNGYTKDKTSFVYQKLIPNSQWTLVGVASLDQLHRV
                     QRQIFWSFLGTGLLACLICSFATVLALRRWIRPIQQLQQVILAIQKGDRQLRAQETGS
                     PELTDLVQQFNALLDQIDSLMVAVADKEKAIGQYRLQALASQINPHFLYNTLDTIIWM
                     AEFNDSKRVVEVTKSLAKYFRLALNQGNEYIRLADELDHVSQYLFIQKQRYGDKLSYE
                     VQGLDVYADFVIPKLILQPLVENAIYHGIKEVDRKGMIKVTVSDTAQHLMLTVWDNGK
                     GIEDSSLTNSQSLLARGGVGLKNVDQRLKLHYGEGYHMTIHSQSDQFTEIQLSLPKMH
                     ELMADDTQENE"
     gene            50712..51791
                     /locus_tag="VHC05_000420"
     CDS             50712..51791
                     /locus_tag="VHC05_000420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="HEQ5401759.1"
                     /translation="MSLASDYFSRQTPIVEKLMAYGFEKRNNGYFYNERFMEEEFEAQ
                     LRIDEAGNIWDRVIDCDLEEDYLPLQQAAWQGTYTGQVRAAYLELLERLSVACFEATP
                     FQSMQANRLAKHITKEWSDPMDYPFEKHPDLATYRVGGKWYAMIFSLLADKLDQIPER
                     LVGQTCEVMTVKVNPKDLPQLLQQEGIYPAYHMSKKNWISIILDDKITDDKLWTLVTQ
                     SRQLVNPNGLSNPNGPDYWVIPANLKYYDIDAEFAANDVILWTQKAGIAVGDYVLIYI
                     TAPVKSIRYVCQVLETDIPNEGYRKNPNIDKLMRLRKCQQYKDGLLSFDLMKEHGVAA
                     VRGPRRLSPQLIAFLKEKEYFKENN"
     gene            51805..52521
                     /locus_tag="VHC05_000421"
     CDS             51805..52521
                     /locus_tag="VHC05_000421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="B3/4 domain-containing protein"
                     /protein_id="HEQ5401760.1"
                     /translation="MVEFVADQSFWELFPDAKLGVVLLKDVQNQAESPEDVKQLLADS
                     HELAKAYLTADNFSDNQVVQVYRKAYQHFKTKKGARSSIEALLKRVSNGQSIPSINPL
                     VDIYNAASLRFGLPAGAEDSDSFIGDLRLTITDGGDDFYLIGDADNNSTLPNELCYKD
                     DIGAVCRCLNWRDGERTMVTEHTKNAFLIIEALDQEGQNRLQEALKFIEGSAKMYLHA
                     ITSVHVLDKDNPHVPLFTEN"
     gene            complement(52688..53161)
                     /locus_tag="VHC05_000422"
     CDS             complement(52688..53161)
                     /locus_tag="VHC05_000422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008087919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEQ5401761.1"
                     /translation="MNKKETRHQLIRSLISETTIHTQQELQERLQKNGITITQATLSR
                     DMKELNLVKVTSGNDTHYEALAISQTRWEHRLRFYMEDALVMLKIVQHQIILKTLPGL
                     AQSFGSILDAMQIPEIVATICGDDTCLIVCEDNEQAKACYETLSHYTPPFFFSNK"
     gene            53303..>53946
                     /locus_tag="VHC05_000423"
     CDS             53303..>53946
                     /locus_tag="VHC05_000423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HEQ5401762.1"
                     /translation="MIRREDYQYLRKLNDFRYFSIEQFDKIVGQMEFRKAKKDHILFF
                     EGDKRDKLFLVTSGYFKVEQSDQSGTFMYTDFIRHGTIFPYGGLFTDDYYHFSVVAMT
                     DVTYFYFPVDLFEDYSLENRLQMKHLYSKMSKLLELHELRVRNLITSSASSRVIQSLA
                     ILLVEMGKDSDTLPFQLTTTDIAQISGTTRETVSHVLRDLKKQELITIKGKYLT"
BASE COUNT        16204 a         9913 c        11671 g        16158 t
ORIGIN      
        1 ctatttagta actttggtta aagtaatcga actaacttag ttgattgtat tttaatgata
       61 aaaagcttaa atttgttgta taacaaattt aagcttttta ttgtttcttt ttaattacag
      121 attgaggttt aaaagacact ttacaatgtt ctcaagtcat gcgttgttgt aggttgtatg
      181 cacatattac aaatcccatt ataaaagaaa ttgtttaatt aatggatagt aatggatggt
      241 atggagatct taatgtggtt ttaatggtaa ttttagcagt tatagtaaga caaaaagtga
      301 cttggaaaag cttatacaga cgattcttaa ctcccacaat atcttctgtc agattttatt
      361 agacttcttc ttggacatga gttggtttac gttttagtac aaattgagat tgagctagtg
      421 tttcagtgtc aattttgtat gatttatgaa cgtgcaggct attcaattgc ttcttagctt
      481 ctaaaggatt aaaccgcatt atctgcgaaa aaacctgaag acgacgagaa tagacattaa
      541 tcgctttaag gataatctca gggttatgga cggttttcaa gtttccaaga agacgattga
      601 ggccgatggt atcgttttgt cttgaatgat tccttatttt agtggtttca ttttcaatac
      661 acgacgtcaa gcgtcctaca tactttgata aaattctacc taaaagaggt gtcttgtcag
      721 ttttgattac aacatcaagt gccaaaagac tttgcgactt aacaagacac ttctacttta
      781 acgcaaagaa aaagtagtga gtactctctt ccgtcggaga tttcctcgct actaaactta
      841 gtattttttg atactttcct taggtagtgc ttaaggcagc gacttccttt ggaattccat
      901 gccttatttt tgagatccta ggctcaaaaa taccaagtgg cgtcaatgtt agtgttgacg
      961 ccacttttac cacaacgaaa aacatctgtt ttggctcact ccacacgcag aaataggaaa
     1021 ttggatgtca aatcagcaga gagctgttca tgctttttga gcctaaaact gagtttgtct
     1081 gcgttctgag cactccttgg gagtgctgga caactcttaa cgattcttca gttcaagata
     1141 acgtttgtac caaatagtga tataggcctt ggaaaatggt cctttttcat gattaatcca
     1201 atcaaccaat attttgacat tttcttttag gataaagtcc atatcggctg aatactgcat
     1261 ctctttttta tgaatctcgt attcatcaac atcaagtaat ctcttttcac catccgcaaa
     1321 gactttgaca tctaaatcgt aatcaatgta tttgagggcc tcagtgtcca tcatatatgg
     1381 actagctaag ttacagtaat aagagacgcc attatctcga atcatggcta taatgttaaa
     1441 ccagtatttt ttatgaaagt aaacgattgc aggttcgcgg gtcacccatc gtctaccgtc
     1501 actttctgtg acaagagtgt gatcattaac tccaatgagg gcattttcag ttgtttttag
     1561 taccatagta tcgcgccaag tacggtgcaa actaccatca tgcttataac tttgaattgt
     1621 aataaagtcg ccttctttag gtaatttcat gccttaccaa ctttctacaa ttaaacttat
     1681 cctctatagt ctatcataaa tgtgtgaaaa aatcacttct tttgtcagtc tataaataat
     1741 ttcttaactt gcaattaata tcgtcgctgt tgtagccttt tcggtagaga gcctgataga
     1801 gcttttgctt taaagtataa ccatcatatt tgcgactgag tttacgatat tgtttgtcta
     1861 attctttgtc aagaagattt tctatttctt gattatcttg gtcaaaatta aggtgattga
     1921 ggctatgttt agctagatcg tatgaaaagc ctttggtcag taatgcttgg gtgattttat
     1981 ctttcaaggc ttttggtggc aatttttctt gatatttgtc aaagagtttt tggcttactt
     2041 tttgagcgag ttggctaaag tcagtttgag ataagatagg atcaatgtca tgacttgcaa
     2101 tgcctttttg taataatttt tgttttaata cttggggacc tttatcacca tttaactgat
     2161 tttggcgaat gtaggtatca gccaatttgg tgtcgtctat ccattgttct tcttggagtt
     2221 gagtgatgat gtcaggaata atgtgttctt caatctcatg cttgcgcagg taatcagcaa
     2281 cttgcttgtt gctgcgttgt tgaaaggaaa gaaaataaag ggctaaattt ttgccgtagg
     2341 acagttgggc aaaatgtttc atgtcttcaa gctgatcatt gtcaaggact ttatctttac
     2401 tcaacataaa ccgaacaata gtatcttctg ttacataaag ggattcgtca ttatccaatt
     2461 cgataaggta caggcgtttt ttcttttcaa ttttagtgat tttcatactt tgattatatc
     2521 aaaaatggta aaatagaaga cgaaaatact gctaaaaatg tgttgcttgt gaatgctttt
     2581 ggtggtgaga ttaggatatt agaggaagta aggggaagag atggtcgtaa aggttaaaca
     2641 gaaaattcct ttaaaaatta agcgaatggg aattaacggt gaggggattg gtttttatca
     2701 gaaaactttg gtatttgtcc ctggtgcttt aaagggagaa gatatttttt gccaaatcac
     2761 gtcggttaaa cggaattttg cagaggccaa actgttgatg gtaaacaagg cttctaagaa
     2821 tcgtgtcaaa ccagcttgtt ctgtttatga aacttgtggt ggttgccaaa tcatgcatct
     2881 agcctatcct aaacagctag atttcaaaga tgatgtgatt aggcaggccc ttaaaaagtt
     2941 caaaccaact ggctatgaac aatttgagat tagaccgact ttaggaatga aaaagccaga
     3001 tcactatcga gccaaattgc agtttcagct gcggtcattt ggcgggacgg tcaaggctgg
     3061 tttattttcc cagggaagtc atcgcttggt tcctattgac aattgcttgg tacaggatca
     3121 actaacgcaa gatattatca ataagattac gcagttagtg gacaagtaca agttgcccat
     3181 ttacaatgag cgaaagattg ctgggattcg gacgataatg gttcgtaagg cacaggctag
     3241 tgatcaggta cagattattg ttgtgagtag caaagaagtt aggttagcga ggttcattgg
     3301 cgaattgact aaggcatttc ctcaggttaa aacggttgcc ttgaatagta atcgttctaa
     3361 atcgagtgag atttatgggg acgaaacgga aattctatgg ggacaagagg cgattcatga
     3421 agaagtttta gactatggat ttgcgttatc accgagagct ttttaccaac ttaatccaca
     3481 gcagacagaa gttttgtatg gtgaggtggt gaaggccttg gatgtaggga gcaaagatca
     3541 tattattgat gcctattgtg gggttggctc gattggcttt acttttgcag ggaaggtcaa
     3601 gtctgtgcgg gggatggata ttatcccaga agcgattgag gatgcacaaa aaaatgccaa
     3661 agccatgggc tttgacaacg cttactatga ggcagggaag gcagaggata ttattcctaa
     3721 atggtataaa caaggttacc gcgcggatgc catcattgtg gacccaccaa gaactggttt
     3781 agatgataaa ttattaaaaa cgattcttca ttaccagcct aaacagatgg tgtatgtgtc
     3841 ttgtaatacc tccactttgg cccgcgactt ggtgcagcta acaaagattt acgatgttca
     3901 ctatatccaa agtgtagaca tgttccccca tacagctagg accgaggctg tcgtgaagtt
     3961 acaaaaacgt gtatgattga gtgccaataa caactcaagt tttataagct caggtaatgg
     4021 gtttgagcaa tagcttgaca tagtagggat gtcaaaaacg gtttagtaag catagtcata
     4081 ttattgataa ctctatgttt attttagaaa cattcatggt taaaaaagtt tgttagtttg
     4141 tcactaagta gggtctattt gaagagcaag tacacacaga caatattagg gtaattggtt
     4201 gttgaaaaaa agctgttttt tgctataaat tagaaaactg agtggtcagg aggttacatt
     4261 accagaagtt attttagtat gctaatatga acgatgatat agaggattta tcctgattta
     4321 atcttttaag ctgtaagaaa cctttgcaaa aactgtaggc tgtgtgagtc ttgatgtgtt
     4381 agatattaaa gataaatgca acactttttt ataatgagat caacaactga taaatctaag
     4441 ttgataacca gtaaaatgat cggaatgtag aaaagttact taatcaagct tttcgtaatt
     4501 taattgttag aatgacagaa cttatgataa aataaagaat atgattaaaa tgaaaaagct
     4561 cagtttatct attacggagt tcgaaatgaa aagaaaatcg agatgtgata acatattttg
     4621 aacgagaagg agaaggataa atgttagaag attttcttca atttttagga tttatatttt
     4681 tagatattat tgaaattatg ttaacgttaa agctttttag ctttgtaagt gcaattccgc
     4741 ttcgcctgaa aaatattttt tatttatcac ttagtatggt tttgtttcaa gtagtttttt
     4801 gggctttctt tccagaccat ttcatccttg atgttgtgat gttggctcag tttcttttct
     4861 ttgcgcttat agccctatac tatggtaaat caataaaagc taagttttta atgttttatg
     4921 ccttttttcc actagtgtct attagtttgg ttaagcgatt tattgtattt tttgttatgc
     4981 cattgtttgg tatgccttat tcagttgtta aacataatac actactgatt tacagcatta
     5041 cttgttttag tatttttttg atttatcgct gcattcaagt ttttcatttc gatttttcaa
     5101 cctggcgcca atattttcaa tcacatagag ctagtaaact attagtgttt actaactctt
     5161 cgatggctct atattacttg tgtatccaag ggatagatgt gatgtcgcct tctttatcag
     5221 gacttgctac aacgactgct cgttcaatca tagtgctctt ttatttcatt ttgtttctta
     5281 ctttattaat tcatttagag cgttatgtaa aacaaaactc tattgaggca attgtgcaac
     5341 aaaaagaata tcgtgagctg attaattata gtcagcacct tggattgctg tatcaagata
     5401 ttcaagagct taggcagcta ttaactaccg tgtccagtcg tcttaagatt ggaatcgaac
     5461 aaaatgatat ctctattgtg agacttactt atgaaggtat cttgaatgct gaaaagaata
     5521 atgctaaaga tgacagactt gatttaactt gtttagataa attacaagtt gaagcaatca
     5581 gacatattgt tttagctaaa ttaattgagg caaaaaataa gaagcttaag gttgaggtat
     5641 cgatccctaa ttgtattgca acgttttttc tagaagtagt agatttcact aagctattgt
     5701 catttttgtt agataatgct atagaaatga gtttggagac aaagcaacct tgcttatcaa
     5761 tagcatttct ggatcaaaac cataaacttg tcatagtcat tcaaagcagt actaaacaag
     5821 gacaaaatga tagtcaaagc gtgtttgcta caccggcttt gaaaaaaaga gatgactggc
     5881 aatttgactt aaggaatgtc acgaccattt taaatcgtta tgactatctc acaattagct
     5941 cgcagattca tgatggcatt ttaacccagt taatagaaat agctaagcct gactgatgtt
     6001 aaaggtatta ataatcactt aaaatcaact taagagtctg agacaatagt cccagactct
     6061 ttttgaatat gttaatctat tactaatgat aatagtttat tgtttcttcc aagctagagt
     6121 taaaatttca gctttgccaa gttggctggg tgtgctttgc ttgctgtctt tttctaacaa
     6181 attagtgacc ttagcattgt agtttggcag gcttaggcta aagtcacaag ttttatcgtt
     6241 tgagagattg tagctgcgcg tgataagggc attgtctgat gggcgacgtt tgaaagccgt
     6301 tagagcgact tgatcgtctg ccccagtgac atagctatgc tctgctctta agcttccctt
     6361 atgatggctg gtttgttcga ctaggatagg aacttggcct tcttgtgccc gccaatagct
     6421 ggcaaattgt gtttgcttag tgatgctttc aaaactataa gataggctgt gtttgccgag
     6481 gcattgggct tcaggagtag ggaaataccc ccagtcgccc atttcaccaa cagaacgtaa
     6541 gagagtgatg gcaatggtgt tggtatctgg taagatctca tattcgttga ggccatagtt
     6601 accaatagtg actccatttt caccatcaaa gagactcaca aagcattctt ggtgctgtgg
     6661 gttacttgga ttcttccaaa aggtggcatc tggatgattt ggacgtttga cagtttcaaa
     6721 aatactgtca gctagatgat ggtctgtttt aaggtgcgtt gggaatagga cgcgcaagcg
     6781 atgattagtc atttggttat caaaacttgt ggtgaattgg aggcgaggat tgtttttctc
     6841 catgcggata agggttgtta aggttagctc agccttttct tgtgaacgtc ttgcttggcg
     6901 ttctgtgatg tcaatgacag cttccatctc agcctgtaag agcttatctg cggagatagg
     6961 aatggcaaag gtttgctgga tttcaagttc agcaacttga gcggtgttgc taatgatgtt
     7021 aagcttggtg gtcccttggt ccgcatagaa aggttggtca tgagttggtt ggcgggaaat
     7081 gtattcattt ccaatatcgc cacaatcttc aaaccgtagg agatcttgat agctcacccc
     7141 tgactgttta tcggtgatgg ttagacggcc atcggtttgt atcataactt ttagaaactc
     7201 attttcaagg cactgattac tatcgtcgta gagtgggacc gttgctgaag gagctgtctc
     7261 gtttcctagt tgtaatgcta aggctttcca agacatggca gggagagtta ttggtagccg
     7321 taatctcact ttgatggcga aataaggttc tcggaaggtt ctcttgggca aatcgtagtc
     7381 aaaggcgatg cttgtgtcca aaatgtctgc ttctgagata gtgtttcctg atacatcaat
     7441 gacttggaaa gattgggaga gtcctgccaa atactcttga gcttcttggt aaacctcttt
     7501 aggaaagcgt tggccaaaat aatatttttt ccaggtcagg gtgagctcag taacacttgt
     7561 tttggaatgg ccactggtat taaataagag gaaaggttgg ctatctgttg gaaagtcact
     7621 cgtgttaact gcgccagcaa tttgctgggc agcttctttt gctaaatagt gtccgacttc
     7681 ataggctttt tcaaaacggt tcatcatttc ccgatgaaca ctatcaacac tacaaccaca
     7741 gatagaatca tgagggtgat tttgcgtgag ggttttccaa gcgtaacgca gttggtcgtg
     7801 agggtaggta cttgtcacct cataagccat tgctgctaag ggttcggtga tgttttcgag
     7861 ttgacgagag actctggtat tagcctgttt gaggtaaatg cgagcagaag ccgtgttagc
     7921 tagggtatac cagccatctg tctcttgact ggtaatctct ccttggacgg ttgaaaggtt
     7981 atctggtaaa tcatttgcga gatcagacaa gtaatcttca aagcaggaat gcacaaattc
     8041 gtaatcagga tagagttggt tggctaaggc gattgccttg gtgacatcaa gttgtacggg
     8101 ttgatgatca cacccgttca tcatcagaag gtgcttggtt gaggcaaagc gttcagcgtc
     8161 agcaagtttt ttatcccaaa aaagacgcgc ctcagcttct gttgtcggga tctcattgcc
     8221 attgctgtac cagttggcga agaggagtcc aagaatacga ctgttatctg ggccttgcca
     8281 actgatttca gagaattgtg agctgtattt ttcactggta tctacttgat tgttaaatcc
     8341 agttggacga atgccacgac caaaggcagc agcttgtagg ccggctttta acatcagctg
     8401 tggtgtttgt cccatatttc caaaggtatc aggaaaataa ccaagtggca cactagcgcc
     8461 ccatctgtca caatcttcct taccaatcag catattgcgc acattggatt cactgctggt
     8521 caaaaaatcg tcctgtaaga tatagaaagg tccgatacgg agttttcccg aagcaatggc
     8581 ttgtctaatc tcaggttctc gttcggggcg tacttgcaaa taatcatcta ggataatggt
     8641 ttgcccatcc aaatgaaaac tatgaaaatc aggatccgtt tgaaaaactt ctaacaggtc
     8701 atctattaag ttaatcagac gcatgtggtg ttgttcgtaa gccatgtacc actcgcgatc
     8761 ccagtgactg tgtgaaataa tatgtacttt tttagttgcc atagtggcct cactttctaa
     8821 ggagtaatgc taaagccaag atagtcaaga agtagttcac aaaacatcat gttagcccaa
     8881 gagaaccact cacgagtgta ttgataagga tcattgacat cgaaaccctc gtgcattaag
     8941 tgggtaccag catctgttgc cacaagcaaa tcaagcatct cttttttact gtcttggtca
     9001 agagcggtca atccttgtaa ggcaagggcg atatgccaga tataattttc tggtgtatgg
     9061 gaagaaccga tgcctgctgc tgcatttccc tgataataat aagggttttc ttggctgaga
     9121 atggtgcggc gcgttgccaa atagataggg tcatctttag cgcaaaaacc aaggtaaggt
     9181 gcagcaagga ggcttggaat attagcatca tccatgatgg aaaactgtcc cagaccatcc
     9241 acttcataag cgtaaatggt ttctcccttg ctgttttgaa caagggcatg gtctgcaata
     9301 cccgattgaa tagcttcttt cagctgcttg gcacgagtag ctactgattc attgtgaaaa
     9361 aggttgttat ataaatcttc tagataggaa agcacaacca ctgcaaacat atttgaagga
     9421 atgaggtaac catactgaca agcatcatca cttggtctaa agcctgacca ggtcattcct
     9481 gttggtgcga caggacttcc ttttccctta tgtgttaggg tatcttcttt gcgccaagta
     9541 tcgcgttcaa acaagtaagg agactgggcg tggtcttgct caactgtcca taggtcaaga
     9601 atgagttcta ccccacgatg aaaatcgtca ttaaactgat cggtgcttcc tgtttcacga
     9661 tagagcaagt aagctagctg aatagggtag cagagggaat caatctcata tttgcgttcc
     9721 caaatccaag ggttcatttg ggtacgatct gtttggtgtc cttttccgtt agcttcttcg
     9781 ttgaaggcat tggcataggg atcgatacaa atgtagcgga attggcgttt gaccaaaccg
     9841 gcaataatct ttctaatttc ttcatcttcc ttggcgagga agaggtaagg ttttatttgc
     9901 gcagtggaat cacgtaacca catggcagga atatctcctg tcaagagaaa gctagtgcca
     9961 tcttcgtagg tttttagggt tgtctctaag gtattggtaa agctggtttt gaaattaaga
    10021 gcccaatcag ggtgttggtc tccacaaagg ctttccacct tggccataaa ttggctgacg
    10081 ctagttggga ttggtcgtgt catatcatat cctccaaaat gatatatcat ttatcttcgg
    10141 tttcattata aatgataagt taaactttgt ctataagttt ttgaaaaggt ttacaactct
    10201 tttttgacat gctatactga taacgggagt aaagaatgac aaaattatta tataaaaaga
    10261 tatatcattt cattaaagag cagatagcat caggtcgttt gcaaattggt gaccgcctac
    10321 ctactgaaaa agaattgtca gaacagttct cggttagccg tattacttct aagcgagcgc
    10381 ttgtagaact ggagcaagaa ggcttgatta cgagaagtcg tgggaaagga agcttcgtag
    10441 ctaaaaagca agtgacgtcc cctgaagcga ataaggattt attgttgatt cttccttttg
    10501 cttctgatta tgaattggga gattatgcta agggaattat gacctccatt gctgaaacag
    10561 gttaccgtct catggtccaa ttggccagta cagtaaggtt agacaccctg tccgattatg
    10621 ctgggattat ttattatcct gaagatgtca atcacagtat tgatttcctg ttttactgcg
    10681 accatcatca cattcctcta gtcttgttgg ataaatctct ggatcttttt cagtttccgt
    10741 ctgttgtagc ggataataaa ggcggtgcct gtcaattgac tcagcacttg attgagcaag
    10801 gctgtgacca gattagtttt gtggcaacag gctcttttgg agaagtatca tccgttagag
    10861 accgttattt gggttactta gcggcaatgg cagaatcgtc tctaaaatcc cattattttc
    10921 ctaagacaga gactgaaaca acagatgctt atttggaccg tttggtgaaa accttatcgg
    10981 aaacgacagc cactaaaagg gggcttgtcg tggaaaacga ttggttggct attcagctga
    11041 ttcaaaaaat cacacaggta ggcttatcta ttcctgatca agtcgctatt gtaggctttg
    11101 ataatagtca agcctcccgt ttgttgagtc ccaaattaag cacagcagct caagattttt
    11161 accaaatggg gcaagaagca gctaaagtct tgttgcagat tattcatgag ccagaccaag
    11221 cagtggtgtc ttgccagtta cctgttcaag tatttatcag agaaagtagt cactaaaaaa
    11281 gacgttacta gcatgagctg tttagctcag gtaaaggaga ccagaaatga ccatttatca
    11341 caccttaaag gattatcaag aagtcatgac aagaggagac tatcttgtct ttgacacgcc
    11401 attgacttgc cgatttattg gccgtttttt ccgctttgaa aatcaaaaag ccctgctggc
    11461 agaattggca acgtcaaagt attttcagtg gattgaagaa ggccaagcag aggtgacgat
    11521 gaaacacttt tttaaccgtc agctggctaa ggatgccttt accctgaagg tttcagaaga
    11581 taaggaaatc attattgaaa gccaaaacct tagaggtttt cgttacgccc aagaagcttt
    11641 gcttaaagtg atgactttca aaggggataa actttattta ccgattgtat ctgtcaagca
    11701 tagtccttct tttgctatgc gggggataat tgaaggcttt tacggaacac cgtggacacg
    11761 agaagagcgg ttagattgcc tacgtttcat tggaaataaa aggatgaata cttacatgta
    11821 tgctccgaaa gatgatgatt accaacgcaa acaatggcga gacctctatc ctgaggattg
    11881 ggtgacttat ttcaaagagc tacttgcagt agccaaggaa gaagggattg atttttggta
    11941 tatgattagt ccgggacttg attttgatta taccaaggaa gctgactatc agttgctcta
    12001 tcaaaaattg caacaacttc tagcgttagg tgtttgtcat tttgggcttt tgctggatga
    12061 tattgactac caaattgtag atgctgttga gagacgattc aaaaagactg cctatgccca
    12121 ggcccacttg gcaactgagg ttcatcactt tttaaaccaa caacatgcgg cgccagaatt
    12181 ggtgatctgt ccgacagaat acgacaacca ccatgattct atctatttgc aagagctgtc
    12241 agaaaggatt cctaaagaag tcgccttttt ctggacaggc ccaagcacgc tagcgagtca
    12301 aatctcgcaa gcagatattg aaaccatggc agcgatttac caacgtccta tcatcatttg
    12361 ggataatatt cctgttaatg attatcaaaa agatccagaa cgtctctttt taaccccttt
    12421 tgctaatcgc tcgccatttt tatgccagcc agactatcag gtcaagggga ttgtttctaa
    12481 ccctatgatt agttgggaat tatctaagct gaccttgaca gacatgagcc attatctgtg
    12541 ggatgctaac cgttatcagc ctagtcattc ttggctagaa accttaacag actatacaga
    12601 agatactgaa ttagccctag ctttacaggc atttgcttgg cataatggca atcgtcatct
    12661 gcacagggac cttccttttg aagtggaaga agctctcctg gctaagaatg tatcaacgtt
    12721 atcagcttgg gtagatgaat tggtagaact tgtcaatacc ttgagaaagc tagataagcc
    12781 agcgtttcaa caagctattg ctccttggtt tgaacgtgtg gccaaagacc aagatttttg
    12841 gcaggctatg ttaaatcagg agcctcagtt ggaaacactc tatgctgact tacaagaaga
    12901 taaacaccgc attggaagtg acattccaag tcgttactat cgcatctact atcaacagca
    12961 agataaacta acagctaatc aaggtcaagt tacccaagca agacctgaag attatgctta
    13021 gtcatacgag ctagaaagga atgatatgtt agcatttcca aaagattttt ggtggggagg
    13081 agccacttca ggccctcaaa gtgaggggcg ttttgctaag cagcaccgca atctctttga
    13141 ttattggtat gagcaagagc ctaccttgtt ttacgattac gtgggacctg atacggcttc
    13201 ggatgcctat catcagattg aatctgattt aaccttgtta gcttcactag gtcacaattc
    13261 ctaccgcacc tccattcagt ggacacgttt gattgatgat tttgagcaag cgacgattaa
    13321 tcctgatggc cttgcttatt ataatcgagt gattgatgct tgcttggcca atggtattcg
    13381 tcctgttatt aatttgcatc attttgacct gccaattgcc ctctatcaag tctatggtgg
    13441 ctgggaatca aagcatgtcg tggacttatt tgtcgccttt agcaaggttt gttttgagca
    13501 gtttggtgat cgggttaagg attggtttgt ccacaatgaa cctatggtcg ttgtggaagg
    13561 ctcttatcta atgcaatttc attaccctgc tatcgtggat gggaaaaaag cagtccaggt
    13621 cgcctataat ctagccctag ccacagccaa ggttattcaa gcttacaggc gaggtccagc
    13681 agaacttagt gatgggcgta ttggaaccat tctcaatctg acgccagcct acccagctag
    13741 tcaatcagaa gcggatacgg ctgctgcgca ttttgcagaa ctttggaaca atgacttgtt
    13801 tatggaagct gctgttcatg ggaaattccc agaagaattg gttgcggtat tgaaaaaaga
    13861 tggggttttg tggcagtcaa cgccagaaga attggctctt attgctgaga atagagtgga
    13921 ttatttggga ttgaattttt accaccctaa gcgcgtgaag gctccggatg tcattccagt
    13981 gattagccca tcttggagtc ctgaatggta ttatgacgcc tacctgatgc ctggccgccg
    14041 catgaacgtg gataaggggt gggaaatcta tcctgaggct gtctatgata ttgctgtcaa
    14101 gatgcgagac cattacgaca atatcccttg gttcttatct gaaaatggtg tagggatttc
    14161 aggagaagac cgttaccgtg atgaaactgg tcagattcaa gatgattatc gcatccgatt
    14221 tttgaaagaa catttgacct acctccacaa aggaatagaa gcaggctcga attgttttgg
    14281 ataccatgta tggacgccaa ttgatggctg gtcttggctc aatgcctata aaaaccgcta
    14341 tggccttgtg gaaaataata tccataccca agtgcgacga cctaaagctt cagcttattg
    14401 gtttaaaaaa gtagctactc ataactgctt gatttcatta aaagtaatgg aggagtttgg
    14461 aggctctgct tctcacctca gtgattgaat gtgtgaatgt ctcctttgag acaagtgaat
    14521 aatgatgtta ccaatgatta aacaagggcc tttttcctca tgttaagagg atcgaggctc
    14581 ttgtatttct ttggaaagtg ttggtatttg ccgaactaga tataagcgtt ctgtctggtt
    14641 tagcattatc tatccatctt gggtaatttg gctcttcaat tctttagagt atcttggcta
    14701 aggatgcttg tttttcatct tggtacttta ggattttctt tcatattttt gggccagcta
    14761 aaagcccctc atggtttcta gtgactgttt gttatgtcac tgtccacgat aaggggacta
    14821 tatgagtgag ttattaagtg aggctttgct tattggcaat aactagcata gcttctaata
    14881 gctcgagcat taactgatga ccaattcctt taacagaagc gtcagcaaca atgacatcaa
    14941 caaagggacc aggcatcagg ctgtgttcat cagcagagag tcatttaggc agaaagccag
    15001 tatcgttgta gctaatcagc aatcctttta ggatgtcttt gtagatgtca gaggcgatta
    15061 gggacaatag gggataagag ggatttagcg gtccatggtt aggcctcctt gtgttcttgg
    15121 taaaaatcaa tggcagctcc cagaagatta gcttcgtttt taaagtgaca aatagctaat
    15181 tggggtctaa ggtcggagat ttcgacggct tggtagagtt tgtctagttc agcttcaatc
    15241 gctgacagta gaaagtcagc ttgggaaaca ccacccccga ttaaaatcag ttgaggatca
    15301 aaggcgtgtt gaatgttaaa aataccgatg gctaaacttt ggagaaagac ctgcctttct
    15361 ttgattgcta ggtggtctcc ttgttctgcg agggcaagga cagctttgcc agtataatct
    15421 tttccgttat tgacgattgc actatagcgc ttggccatat ttaccactgt ccctaactga
    15481 ctaaaggttt ggtagcggtc gttcatgatc atgaaaccaa attcgccccc aaataagtgg
    15541 gcaccatggt aaatcttgcc atcaatgacc aagcttcctc caactccagt accaagaacg
    15601 agcatggcta ggctactagc gccttttcct gcccctaagg tagcttcagc taaggcggca
    15661 caattggcat cattttcgat agaaataggg taatgtagcc gttcttctaa ggcctcttgt
    15721 attttaaaat ggtgaatgta gggaatggcg ctggctcctt cgataatacc tttttccttg
    15781 ttaaccgctc caggagcact aacggcaata cctgagaaat ggtaagcaga gtaacgagca
    15841 acttcttggt cgagtaattg gtaaaacttt tccagactag agggagtggg aaagctgctt
    15901 tgctggctta attggccatt gtgacagagg gcaaatttaa gggaagtgcc tcctatatca
    15961 agacataaca agctcatgag gtgttctcct ttattgtagt agaatagacg atcatgtctc
    16021 atcttagtat gacagattta agcaacaatg aaaaggcttt ctaagtgatt ctatattttg
    16081 tgctatcata cctataattt gtgttatcat acctatattt tgttgctttt aaataatgaa
    16141 agcgcttgat atactgtaac tataacgtga ttaacacaaa gggagattgg gaaatgacaa
    16201 gacaaaccaa caaaaagaca tccttttgga aaaatgtgat taaataccgg gccttgctgt
    16261 taatggtatt accaggtttc atctggttca tctttttctt ttatattcca gttttagcca
    16321 atgtggttgc ttttaaagat tttcattatt cagcaggggg ctttatggaa agtttgaagg
    16381 agagcccttg ggttggtttg gctaacttca aatacctctt tgcttccaaa gatgcttggt
    16441 tgattaccag aaataccatc gcttacaatg tgattttctt actctttaat gttttctttg
    16501 cgattgcttt tgccattatc atgagtgagt tacgaaataa gcgaacggtt aaggtctatc
    16561 acaccatgtc cttattgcct tatttcttat catgggtggt tattgaatac tttgtttctg
    16621 cctttttaaa tacggataaa ggtttcatta atcagctctt gactggaagt ggaggagctc
    16681 caatcaagtg gtattccaat cccacttggt ggcccttgat tttacttttc atgagtgtct
    16741 ggaaggggct aggctacaat agcattatct actatgcttc agtcaaaggg atttctgata
    16801 cttattatga agctgctatg gtggatggtg caagcaaatg gcaacaaatt aggaacatca
    16861 ccattccaca attattgcca atgatgtcta tcctattgat cattaatatt ggtaatatct
    16921 ttaaatctga tttcggactt ttctacgtta ttcccaaaaa ttcaggccca ctttatgacg
    16981 tgaccagtgt gttagatacc tatgtctaca atgccttgac tgctacagga gatattggga
    17041 tggcatcggc agctagcctt tatcagtcag tagttgggac cagcatcttg ttagtcacca
    17101 atgcgattgt tcgtcgcatg gaccctgatg catccttgtt ttaggaggaa accatggaga
    17161 aaaagaaaaa agtcgaaaag gttaatgtta gaacctttga tcgaaaaacc aatgctatct
    17221 ttaatattct gattggtctg tttgccatct cttgtatcat tccttttatc ttcgtgatta
    17281 ttatttcctt cactgatgaa agttacttga ttaatcatgg gtatagtttt tttccagatg
    17341 tctggtcaac taaggcttac cagtatattt ttcaaggagc catgtcccat agaatcatga
    17401 ggtcatttgg gatatccgtg tttattacag tggtgggaac ctttattaac acgaccatga
    17461 catcaaccta tgcttatgcg atttcaagac cttatttccc atacagacgt ttttttactg
    17521 tttatgcact tatcaccatg ctctttgcac cagggatggt tgctaattac ttggtggtca
    17581 gcaatctcct tcatttgaag gatacggttt gggccttgat tttaccaatg gctctgggcc
    17641 catttggcat cttggtcatg agaacgttct ttaaaaagac agttccagat agcattattg
    17701 agtcggctcg tatggatggg gctagtgaat ggatgatttt tatgaaaatt gtcttaccat
    17761 tagctgttcc agggattgcc accatcagtt tattttctgc cttaacttat tggaatgatt
    17821 ggtttaatgc cttgctttat gtgcaaagtg aaaacctcta cccaatgcag tacttactga
    17881 tgaaaattca gagcaaccta caggccttgg cacaaaatgc tggcatgagt gcacaaatgg
    17941 cagatagctt agcatcgctg ccaaaagaat cagttcgtat ggccatcgtg gttattgcaa
    18001 ccttgccgat tgccttgact tacccattct tccaaaagta ctttgttggt ggtttgacca
    18061 ttggtggggt gaaggaatag gacttaagga actggtcaca agaccagatt ttatctaatc
    18121 attagtaaca aaagaaaaca ttttttagga ggcttcactt atgaaaaagt ggcaaaaaat
    18181 cgtgtgtgtg actggaactg tgcttgcagc gtctagttta gcagcctgcg aaagcaagtc
    18241 agcatcaaag gatagtgatg tcaaattatt gatgtaccaa gttggtgaca aacctgataa
    18301 cttcgatgaa ttgatgacaa ttgctaacaa gcgcatcaaa gaaaaaacag gtgcaacggt
    18361 tgaccttcaa tacatcggtt ggggggactg ggatgataaa atgagtacca tcattgcctc
    18421 tggtgaaaac tacgacattg cttttgccaa taattatgtg gtcaatgcac aaaaaggtgc
    18481 ctttgctgat ttgacaacgt taatgccaaa atacgctaag aaaacgtata aaaacttaga
    18541 cccagcctat attaaaggaa atactattga cggtaaactc tatgccttcc cagtagatgc
    18601 caacgtttat gcccaacaga tgctttcttt caataaagaa ctagtggaca aatatggcct
    18661 tgacatttca aacattaagt cctatgcaga tgctgaaaat gtcttaaaac aatttcacga
    18721 aaaagaacca aatacagcag cttttgctat tggtcaagtc tttagtatgt caggtgacta
    18781 tgactaccca ttaaccaaaa accaaccctt tgctgtgaaa attgatgaag gcaagccgac
    18841 catcattaat cagtatgaag atgagtcctt taaaaacaat ctccgcttga tgcacaaatg
    18901 gtataaagaa ggtttgattc caacagatgc agcgaccaat acagaaggtt atccccttga
    18961 aggaaacact tggtttatgc gtgaagaaac ccaaggtcct atggactatg gcgatactat
    19021 cttgaccaat gctgcaggaa aagacatcgt gtctcgtcca ttgactaaac cgctaaaaac
    19081 cacatcacaa gcacaaatgg caaactttgt ggtatcaagc gtatctaaaa acaaagaaaa
    19141 agcagttgaa gtcctttctc ttcttaatag cgatcccgaa ttgttaaatg ggcttgttta
    19201 tggtgtcgaa ggcaaagctt gggaaaaaat tggcgacaag aaaatcaaac tgctcgatgg
    19261 ctatcaacca aaaatgcaca tgggtgcttg gaatactggt aacaataaaa tcctttacac
    19321 tcaagaatct gttactgacg acatgattgc taaacgtgac caatcaatca aggatgctaa
    19381 agaatctcca atccttggtt tcactgttga cacaaaagtt attaaaacgg aattgtcaaa
    19441 tatttcaaat gtcatgaacc gatataaagc aagtatcaat actggtacag tggatcctga
    19501 cgaagccctt ccaaaacttc ttgcagacct caaaggtgct ggttgggaca aggtgcaaaa
    19561 agaagttcaa aaacaattgg acgactttgt agctaaagac aagtaaggca ttcattttct
    19621 tgattataag ttgagggctg ggaaatctca gctcttttct tctgatgagt ggaaaaaacg
    19681 gatcatcaaa taagtggaag ttataaaggg agaaaaatta atggaaataa tgttactact
    19741 cttagtaaag cggtttccaa aagcctataa agtgtgctat attagaagag tctaaactat
    19801 taatcagagt aaaactaata ccagcatctt actaggggtg ctaaaactag tctcgtagct
    19861 gctggtccct gaaaccgcta taagtgttaa caagaaaaag aggactatca tatgaatggc
    19921 attgaaaaaa cctgcttttt aatttggaaa atgatccaat tgaccctcat ttttcatctc
    19981 ttgtccttag ctggactgat tgtgtttggg gtggggcccg cctggcaaac cattgtcacc
    20041 ctatttttaa aaacacctca agaagaaaac cactattctt tgaaaagggc tgttcaactt
    20101 tggaaatctt atttcaaaga agctaatcta agatttggtc tttttgccct gactttcctt
    20161 tttttaacct ttaatttgca ttgggcagta cagtttccat ccttgttttg gtttaccgtg
    20221 tctttcttga ttgtaatagc catggtttgg ctaaccatga cctatcttta catggttttt
    20281 tatgcagtga gctatgagat taacctttgg aataatatga aattagcctt tatcagcgtc
    20341 tttttaagtt tcaaatcctt tttactcatg ctgagtgttt tgctgggaat taccttaatg
    20401 acttggcaat acaaaggcct ttatctcttt ttaaccttcg gagctctagt cttttgcttg
    20461 gactttgtca ctaaggctaa tcgtcgacta gtagatggag tgattgatga gtgttaaaac
    20521 attgggaagg tatgtgacta accactttaa gcagggtttt ttgattaatc gactgatgaa
    20581 attatatagc ctgctaattg taagtttttt cactttatca gctattggct tgagcagtta
    20641 ttctattagt agtacttata aaagggtgga tgctgaggcg cagatgcgac tggaggagac
    20701 tctaggtaga ttgcagtcac aaaacgatat taccctacgg gttttagacc agttggttgg
    20761 ccgttcagaa gattaccata acctctatca atatatgacg ttaaccccaa accaatattt
    20821 ttcaaacgtt tttgaagact gggaaaaagg aaaagacacg gtcctatttt ctgaagaggt
    20881 gaggcgtctt tttgacttgt accctgatgt gacttctatg accctactgc tagaggacag
    20941 tagtgcttac ctgtacgccg acagggtcat taagacgggg cgtttgcttt atagcaagcc
    21001 tgaaaaagta accggaaatg ttttagttcg ctctattcga aatccagaat caggagatgt
    21061 gacaggtcgt ctttacctga cttttgacaa accaccgact ttggtagaga cacagcagga
    21121 tcactattta gctacttttg cttttgatta ctatggccgc aaactcttcc atcaaggagg
    21181 tcggagattt cctcatttag aggctgaggt taaaaaggct atcaaggcag atcgggcagc
    21241 tgatcttagt aatcttagca aggcttatcg gatgcagtac aatcgctcgg gagacctctt
    21301 agcttatgtg gctgtcagaa aatcctattt attagcggaa gctgtcagga cagtttttgt
    21361 gtatggcctt gtttctctac ttttagcttg gctgttattg cagttgctct ttagggtttt
    21421 ccgaaattat atccagcagg tttctgaaat tacggatact gttgaaatgg ttgcagcagg
    21481 cgatttgtct ttaaccatcg acaacagcca catggaattg gaactgtatc atatctcaga
    21541 agccattaat cagatgttgg ccagcattaa agcttatatt gacgaagttt atgtgttaga
    21601 ggtagagcaa cgagatgccc aaatgagagc tctgcagtct caaatcaacc ctcatttttt
    21661 atacaacacg ttagagtata ttcggatgta cgcccttagt tgtcaacaag aagaattagc
    21721 agatgtcatt tatgcctttg cgagtctgct tcgcaataac atcagccaag ataagatgac
    21781 caccttaaaa gaagaactgg ctttttgtga aaagtacatt tacctttatc aaatgcggta
    21841 tccagatagc ttcgcttatc atgtaaaaat tgatgagagt attgctgact tagccattcc
    21901 taaatttgtc attcaacctc tcgttgaaaa ttattttgtg catgggattg attatagtcg
    21961 ccatgacaat gcactaagca tcaaggcttt agatgagacg gatcatttct tgattcaggt
    22021 gcttgataat gggcgtggta ttagtcaaga gcgcctagca gatatggaaa gaaggcttca
    22081 agagcaccaa acaacaggca atagctctat tggtttgcaa aatgtttacc tccgtctctt
    22141 tcatcatttt cgagacaggg tttcttggtc catggctaag gagccaaatg gtggctttat
    22201 cattcaaatt aggattagaa aggatgcttg atgtataagg tactattagt tgacgatgaa
    22261 tacatgattt tacaagggct caccatgatt attgattggc aggcacttgg atttgaagtg
    22321 gttcaaacag caagatcagg caaggaagcc ttagcctatt tgactcagta cccagtggat
    22381 gtcatgattt cagatgttac catgcctgga atgacaggac tggatttaat agaagcagct
    22441 aaaacctatc atcctcagct acaaaccttg attttatctg gttatcaaga attctcctat
    22501 gtgcaaaagg ctatggaatt agaaaccaag gggtatttgc taaaacctgt tgataaggca
    22561 gaattacagg ctaaaatgaa acaatttaaa gactgcttgg atgcccagca ggcagaatca
    22621 atccggcaag aagcctatca tgacagcctt ttgacccttt ggcttacaga tgaattgagt
    22681 gagaaagaat ttcagcagct aagtcaaggc ttgccagcgg ctgctttaac tggttttaca
    22741 gtgctgtatt tagactgtca agagtggcaa gcagccatcg atgcttattt tgaacgagaa
    22801 ggtcagcctt tttacctcaa aaaagaagaa gataagaagg tttatctggc tgtcctactt
    22861 ggtaaaactg accaagccaa ggcatttacc tatgacctac aaaagcgatt ctcaagaaac
    22921 atgcatcaac ttattttggg agaaacagtt gatgactggg aaaatgttta tgaaagctac
    22981 aatcaggtgc ttaagagcct cttttacaat tgtgaagtgt caccaattag agcaaaagat
    23041 aagtccaaaa ttgaactacc ggagtcccgt ttgcagttct ttgcttttaa caaggcgttg
    23101 atgattgggg acgaacctac aatcttgtct aaattagaag ctatttttga cgagatgaag
    23161 accttgaact tttcaccaga ggatgtgaag catgtttcgt tcttgttgtt ttctgacatt
    23221 taccgtcaat ttcccatttt agataaaatg acttatctgt ccatggtaaa aactattcat
    23281 gacagccaat ccattgatcg cattttgagg gaactaaaaa aagtgttgga tgtcaccaat
    23341 cagaacaatt cccctgaaaa acgctattca gatttagtta gtgaaaccat tgattgcatt
    23401 cgcaaggaat accatcaaga attaaccctt aaagctatcg ctgataggtt acatgtcaat
    23461 ggggtttatt tagggcaatg ctttaaaaat gaaaccgagc gtagttttac ccagtactta
    23521 aatcatgtta ggattcaaaa agcgcaacag ttattgcttt acaccaacca atccatcaat
    23581 gaaattgctt atgaaacagg ttacaatacc aatcattatt ttatcaagat gtttaaaaag
    23641 ttgaatggtt tatcgccaaa agagttcaga gatcgttaca aggacaatta ccaagctatc
    23701 aagggtgacc agtaacgtta aacaggagat tgatatgaca tcagatagca aggagcagac
    23761 agtgactggc taccaatacc actatattga tcaagaagga agaaagcagc cctttaatca
    23821 aggctggcgt tttcttatgg cagatgtggc gtgtgctcag gacccttctt ttgatgattc
    23881 gaactggcag gtgattcatt taccacatga tttcagtctt acgcagcctt acacaagaaa
    23941 tggtgaagct gaaagtgctt ataaattagg tggtgtcggt tggtatcggc attatctcgt
    24001 gttagatgag gttttagctg gttatcatgt tgccattact tttgagggtt cctatatgga
    24061 aacggaaatt tatgttaatg ggcaattcat tggcaaacac ttaaatggct atcaggaatt
    24121 tacctatgat atctctgatg tagtgacttt tggagctgaa aatcttctgg ctgtccgggt
    24181 tgaaaacaag gttcccagtt ctcgttggta ttcaggcagt ggtctttatc gtgaagtgag
    24241 tttgtctgtt cttccccagc ttcattttgt ggcagaccag gtagcaatga ccttggctga
    24301 tactgctgtg caggagaaag ggcaacagaa agttgattta cgctttgccc ttaatcagtc
    24361 tattcagact tgccactacc aattgagcct ctgtttatgg gaacaatcac attgctcaaa
    24421 agacaagaaa ctcctttatc aagaaacaga agtgcctcta gctgatttgg ctttccaaag
    24481 acagtatggt cttacactgt ctttggaaga actccaattg tggtcaccag ataatcctca
    24541 cctctacgat ttagaactca ctctttacta tcaaggtcag gtcattgatt gcttttgcct
    24601 tgaaactggt tttcgtcagc tgacttttat ggccaatcag gggctttttg tgaatggcag
    24661 agctgtcaaa ttaaagggag tttgtttgca tcatgaccaa ggaggcctag gagcttgtgc
    24721 ttacgaagat gccctagcca gacaattagt cctgttgaaa gacatggggg ctaataccat
    24781 tcgtagcacc cataacccaa gtagtcccaa acttaggcaa ctagccaatc gtctcggctt
    24841 ttttgtgatt gaagaagcct ttgacacctg gacctatgcc aaaaatggaa acgttaatga
    24901 cttttcaaac tatttccatc agactatcgg aactgaaaat gcaaactatc ttcaaagagt
    24961 gaggtcacct gaaacgagct gggcccagta tagtattgag gccatggtct ggtctgccaa
    25021 gaatgacccg tcagtgttga tgtggtcgat tggtaatgaa ttgatggaag gtttttcagc
    25081 cgatgtcagt cattacccag agctgacaag acaaatgtgt caatggattg ctgctattga
    25141 cacctcacgt cccattacct ttggggacaa taaattaaaa gaagctgact tttgctggca
    25201 tgaggaagtg tcgcaaatgg caacttttct tagtcaatta gaccatcccc agggactcat
    25261 tgggttaaac tatgctaatg gaaaagacta tgataagctt catgaggagc actctgattg
    25321 gctgttgtat ggttctgaaa cagcctcagc cattaccagc agggcttatt ataaagagcc
    25381 aaaaaaagtt cttgactccg gttatcacct aacctcttat gatcatgcta aggttgattg
    25441 gggtgccttc gctagccagg cttggtatga taccattacc cgtgattttg ttgctggcga
    25501 atgcgtttgg acaggctttg attatttagg agaacctaca ccctggaaca agatcgacag
    25561 cggtgttgta ggcctttggc cttctcctaa aaatgcctac tttggcattt tagacacggc
    25621 aggctttcca aaagatagct attattttta ccaaagtcag tgggcgcagg ggcagaccac
    25681 cttgcacctg ttaccagtct ggcagaagga ccagctttgt ttcgatgagc agggattggt
    25741 ggaggttgtg gtttatagca atgctgccag tgttcaactg atgtttgaag atgagcaggg
    25801 caacttaaca gattatggaa ggaaggcatt tcatacttat agcacgccaa cgggacacac
    25861 ttatcagctt taccaaggag ctgacgctgc taagaatcct cacgagaacc tttacctgac
    25921 ttggcgagtg ccctatcaaa aagggttgct aagggcagtg gcctacgaca tttctggtaa
    25981 aagcattcca aaaaccagtg gacgttctca ggttagaacc tatggttcag tggcaaagct
    26041 atcttggaaa gcctttgaag cacctattga cgctccttgg gaattgcttt atctggattt
    26101 atcactcttg gatagccgag gtgaattggt cagccatgct caagattggt tgcaggttca
    26161 agtagaagga ccagcccgtt tgttggctct tgataatggg aatccgactg accacactcc
    26221 ttatcaggag cctctgcgcc aggcatatgg gggaaaatta ttagccattt tagccctcac
    26281 tggagaggag ggacacatta aggtcacggc aaaagtctcg cagcaactta gcagtgtttt
    26341 tcagacacaa gtagcctgcc gtgcccccaa agaacactta gtgacactac ctttagagaa
    26401 atatcagttt aaaaagagcc gactgacaag tcaacaagaa attggtcaat cttgtctaaa
    26461 gaccacacaa ttcctttctg ttttggagaa caaagacacc cagcaaaaag caggtaaggt
    26521 tagcacacct cacattctta tcaccagtta ccagcactat ttatctctgc ccttgcaggt
    26581 ttgttctcag gcatttgatt ttaaaaaagg cgacgatatc ttcttgcctc agtggctcca
    26641 agtcaaagat gcccaaggtt ctcttgtgaa aaaagctttt tcaatgacgt ggtacctaaa
    26701 agagaaaatc tttgccaagc ctattcttgt cacaggctat gtttcttgtt ttgggcaatc
    26761 aataccggtt gaggcaaggc ttaacctagc acaagctagc aaaagacggc accaggatct
    26821 cagtttagtc gccaagcaat ccctgaccgc aagtcaaaaa aggctaactt attgctacca
    26881 atatgatacg gtgcaagcca taggagccat tagcttgcaa aatcacacag acacatctct
    26941 tagtgtttct gtggcaatca gttatggtag tcagagctct attaagcaag aaaccttgat
    27001 gctagctgat agccacttga gccagttaga agaggttatt ttcttcgatg atattttgac
    27061 tgttttgtat ctatccgtga cccttgaagt cattgaagga cctgacctaa ctgaagacag
    27121 tattcaaatt ggcctttggg atttagcatg aagcatgagt agaagaagac ttctttggca
    27181 ccaggtctga tgaattctgt aaaataaggt ataataaaaa acaaataggc gtcctttatt
    27241 acgtgaaagg cgcctttaca aggttgaaat ggaaagtgag atttctaaat gtcagaacgt
    27301 ttatcaggcc acaccctgct ggtctctttg cttgctactc ctattcgtca tagtttgtct
    27361 cccaaaatgc acaatgaagc ctatgctaaa ctggggctgg attatgccta ccttgctttt
    27421 gaagtaggga cagagcagtt agcagatgcc gtgcaaggga ttcgtgcctt aggaattcgt
    27481 ggctccaatg tgtctatgcc aaataaagaa gctattttac ccttattgga tgacttgtcc
    27541 ccagctgctg agttggtcgg tgcagtcaat acggttgtca ataaggatgg taaaggacat
    27601 ctcgtggggc atattacaga cggtatagga gcgctcagag ccttggctga cgaaggagtg
    27661 tcggtaaaga acaaaatcat taccctagca ggagttggtg gggctgggaa agctatcgct
    27721 gtccagctcg cttttgacgg cgccaaagag gttcgtttgt ttaaccgaca agctacacgt
    27781 ctaagtagcg ttcaaaagct tgtgacaaaa ctgaaccagc taacaaggac taaagtaacc
    27841 cttcaagact tggaagatca gactgccttt aaggaggcca tcagggaatc tcatctattt
    27901 attgatgcta caagtgtagg aatgaagcct ttagaaaatc taagtttgat taccgacccc
    27961 gagctcattc gcccagactt ggtggtcttt gacatcgtgt acagcccagc agaaaccaag
    28021 ttactagcct ttgcccgtca acatggcgcc caaaaagtca ttaatgggct agggatggtg
    28081 ctttatcaag gagcagaagc ttttaaatta atcacaggtc aagacatgcc agttgacgct
    28141 attaaacctc ttttaggtga tgagtaactc aacccttttt aaagaacttt ttaagtaagc
    28201 ttaattatga tatattaata agagatggag cagtcatcat gggctgctaa aattcttttt
    28261 gcgagagctg tttttaagag caaaaagctt atttgaagag ccttatccct aacgtgatac
    28321 aagtcatagt tcttttgagg tctgccagat aacctaccgt ttttttagaa aagaagctct
    28381 tataaaagga aaagttcaat gaataaagga gaatagcaat ggtaacaaag gaagttgggc
    28441 atgacttttt agcacgtcta ggaaaaaaac gcttaagacc tggcggtgtt gaggcgacaa
    28501 actggttgat tgaacaagga caattctctc aggattgtca cgttttagag gttgcctgca
    28561 atcgctgtac gacagcaata gagttagcca aaaccttcgg ttgtcagatt gatgccgttg
    28621 acttaaaccc caaggttgtc aaagaagcac aagaaagggt tgctgttgag gggttaaccc
    28681 gtcacattac agtatcccaa gccaatgctt tatcactacc atttccagat aaccattttg
    28741 atattgtgat taatgaagcc atgttaacca tgttgaacgc ccaagccaag gagaaggcac
    28801 tcaatgaata ttggcgtgtg ttaaaaccag gcgggcgact tttgacacat gacgtagctt
    28861 atgaagatcc aaaaacaaga caagtacttg acgagttacg tcaaacgatt catgtcaatg
    28921 ttgctccctt gtcactaaca ggttggcaag ccttatatca agaacacggt ttttctcaag
    28981 tgacttatca ccatgggaaa atgtctttga tgacacctcg tggaatgatt aaggatgaag
    29041 gtcttatgaa caccctgaac attatgagac gaggccttaa gaaagagaac agacaacagt
    29101 ttttaaagat gcgtcgtttt tttaccagaa caggcaaaaa tctctgctat attgctgtaa
    29161 aaagtgtaaa ataaacctta gaccaacctg tccatacaac taaacagacc atagaggagt
    29221 tcgaagatgt cttatatcaa taatattgag cacgcgaagg ttcttgattt gacgcaagaa
    29281 gtaatgattg agcaagatca aatgttaagt agaacactag tccaaaggca agacctagga
    29341 ataacagttt tttccttaga taagggccaa gaaattgggc gacactcatc accaggagat
    29401 gccatggtta ctatcttaag tggcttagca gaaatcacca ttgatcaaga gacctaccga
    29461 gttgctgaag gtcaaaccat tgtgatgcca gctgggattc ctcatgcctt atatgcagta
    29521 gaagcctttc aaatgctttt agtagtagta aaaccggagg cttaacatga ttgaaaatct
    29581 ctctcaattg gtgcaatatc atgatcatca ggtggctagc cgatccttga gccgtctact
    29641 gggattatct caatctattg ttttatatgc catggcccaa ggagaaagca ttagtcaaga
    29701 gactagtcca agagataaag taatacttgt tttagaaggt cagctcattt tcgatttaga
    29761 ggatcaaaaa caggtcctaa ctcaagaaag tctcatagcc atacctgccc aaaaagtcca
    29821 tcatttagaa gctaaaaccg attgtaaact attacaagtg cttttagatt aagggcttat
    29881 tgtcaactgt attgggtggc ctatggaaaa gcaaaagaga aggtgacgct catcttctct
    29941 ttttacgtat tcaaagcgat gacaatacga attttaaagc ttggctttct catctccaga
    30001 ttaagccctt tagcttggtt tattttagaa ttcactaaaa aaaccttaat gagtttccta
    30061 tctccttata ggtttctcat taaggctttt tagacgaaat aattgaacga caggcaaaag
    30121 aaagatcttt ttacgagtga taccgttctc ctatagttcc ataaatcctc tttttgatgt
    30181 tgctgttagt tattcttagc taaaagttat attgttatca agacttgtct tgtagtaaca
    30241 tgttttagga gttccaggat accgttattc tcttagcaag cttaactagc tagagtggag
    30301 tcactattta taataaactg tcgagcttct cgacaaattg gtgatcgtct ttgttaatgg
    30361 ctagggtggt aaaaccggtt tctgtgggta atataaagat aatatgttgc tcagaattct
    30421 tcttatctgt tttaaagacg tcaaagaggg atgtcgcaga gacatcagct ctttcaagtg
    30481 ttgttggtaa ctggtaacgt tcaaaaactt gaaggaggct atccaagtcc tcttttggca
    30541 agagtccttt ggaaacagcc agtttagcat caaccaccat accgatagca atggcttcac
    30601 cgtgatggta aaaatcatgg tgacagagcg attcaatcgc gtggcccaag gtatgcccaa
    30661 aatttaaaga catgcgcaaa ccattttcaa attcatcttg ttcaacaatc cgttttttat
    30721 tggaaatgga ttggtaaatc agacgttcaa gtccctgctt atcggtttct ttttgaaaat
    30781 cacgtaactg ctgaaaaagc ggtctatcat gaatgaagcc gattttgagc atctcactga
    30841 tgccgcagga gaattcccgt tgcggtaagg tttccaaaaa ggtggttgaa ataatgacag
    30901 cttctggagg gtaaatgctg ccaatcatat tggttagact tttaaaatgg actccaactt
    30961 tgcccccgat actgctatcc acctgactaa gtaaagtcgt tgggatttga atgtagggaa
    31021 taccacggta ataggttgca gcgacaaaac cacccagatc cccaacaaca ccaccaccaa
    31081 tagtaacaat catatctttt ttggaaaaat tttcagcgat gagctggtcg tagatagcac
    31141 tgacacgttc caaggatttg gattgacctc ccggggggca gacatggaca aaagcgttgt
    31201 attgctgagc aaattcttca aagagagtct gatacaagtg gtagaccgtt tgatcggtga
    31261 taaacaagag tttacgctgc ttgcgctcac caaggcaatc tgctaaggtt tttaaaacat
    31321 ggtcggtaaa caggatatca taatccttga cccgagaatg gacatgaagt gtttgtggca
    31381 taagcactcc tttcatcagt actaggtaac agagataacg cagtgatatt tagagcttaa
    31441 tcttgccaaa gttcctgccc caactgttct aattgcttat aatcaatttg ctgggcagca
    31501 tctgacagcg catggtcggg atcaggatga acctccatca tgatgccatt ggcaccgaca
    31561 gccttcgcta tcttagcagc aggtaagagt aaatctcgtc tgcctgtcga atgagacacg
    31621 tccacaataa tcggtaaatc tgtcttttgt tgaataatag ggactgccat aatatcaagc
    31681 atatttctag tctccacatc gtagccacga acgccacgtt cgcataagat aatgttagac
    31741 tttccagtgt cttgtaagta ggaaagggcg cccaaatatt cctcgatagt agccatcaag
    31801 cctcgtttaa acaaaatagg cttatcgatg tgtgacaagg tttttaaaaa ttcaaaattt
    31861 tgcatgttgc gggcaccaac ctgaatgaca tcgagatagt cataggcttc ttctaattgg
    31921 cgctcggaca tgatttcact gaccgatagt aagccaaatt cctgacaaac ctcatgcaag
    31981 taacgaattc cttgcaggcc aaggccttga aaagaagcag cagatgttct tggtttatag
    32041 gcgcctcctc taaaatagtt gtaaccaagt tttttggcac ttgaagctgc taatctaatg
    32101 tgatcataag attcaatgga acaaggtcca acaataaaat tattcttaga acaagtctta
    32161 ttttgaaagt cagacataat gtcaatcatt cgtttgattc ctttactaat tctgtatggc
    32221 gtgctctatg ggataacgtc ttatttagga atacaaaatc tcgttgttat ccatgaagca
    32281 cccttagcct gtgaaatgat accataaaca agatgaaata gcaagtaaac cctagattgt
    32341 ctatgttctt agtcattttt attaaaaaag gcttactagc tataaaaaaa tactgcccta
    32401 aatcttatta ggacagtatt tttttataga tgccaccacc gagaatcgaa ctcggaacga
    32461 agcattacca ttgctttatt ataccattta actacagcgg ctaccttttt ataatactat
    32521 aagttattaa ttgatgcaag cttttcttaa aaatatttcc ttaattgttt atcatcaaaa
    32581 tgagagtacc agttattaat aacatggcac aagaggcctg ccttatggta taatggtaaa
    32641 gatgatttca gaaagaggaa gccaagcatg tcttatgaaa aagaattttt aaaagatttt
    32701 gaagactggg ttaaaactca gattcaagtc aatcagctag ccatggcaac cagtcaagaa
    32761 gttgcccaag aagatggcga tgaaagggct aaagatgcct ttattcgtta tgaaagtaag
    32821 ttagacgcct acgaattttt actaggtaaa tttgacaatt ataaaaatgg taaagccttt
    32881 cacgatattc cagatgagtt atttggagca aggcattatt aaggacaagg agatacgaaa
    32941 tagtggcaaa acaaaaaaat cgtaaaaaag cattgaagtt agaaatgaag cgtaatggct
    33001 tgttaaaaaa agcaggtcaa gtttttgata aggcagttga aagtgttgaa acagccgtgg
    33061 ataaaaccat ttctgctggt aaaaatcttg tggaaaaagg cagccaaacg gttgaaaacc
    33121 tgacagcaag caaggaaaga cttactcttg atgagtttgc agggcagcca gttgtagctg
    33181 gtatccgctc tgaccttgtc gaaaccctat atgcagaagg catccattca gcgcaagctt
    33241 ttaaggagtg gacagaaaaa gacctccttg ctcttaaggg cattggccca gcaacggtta
    33301 aaaaattggt cgaaaatggc gcaagcttta aaaaatagtc atcttctcgt tgcttaatgg
    33361 ctataaattt gttagaatat tagcaatcag aggtgcattg agttggtctg ttacagagag
    33421 cggtggtgtt gagaaatccg cacagatgtc aaggctggta gctgaggata agaaatcaga
    33481 tatgaaaagt agcagaccca ttttatggtc tgaaacagtg gtggtaccgc ggaaatcgta
    33541 acacgaaatt cgtccctgtc cagtgtaagc tggataggga ttatttggtt tcatttgaaa
    33601 gaagatgatg gcttattgtt aaaatgttgt tagaagtata caatagaaaa actttgccca
    33661 aagtggaaac agaacggctg ctattacgtc aacgaaaagg ggacaaggca ttgttccaga
    33721 agcggcttca gctctgattg aaattggttt taccttactt gatttgcata aaattgagct
    33781 gggttgctac gactacaaca agcaaagtca ggcagtggct cgcaaattag gctttacctt
    33841 agaagccaat gcccgtgacc gtaaggacgt tcaaggtcgc cgctgtggcg acatgcgttt
    33901 tgggttactg agaagtgagt gggaggagca gaaacaaaaa tgaaccttat catcattggt
    33961 gctcaagcgt cgggcaagat gaccattggg caagaagttg ccaggcagac aggcatgact
    34021 ttgtttcata atcacgattc tattgatttt gttttacggt ttatgccttg gtctcaagag
    34081 agcactgcct tgattgaacg tatccgtttt gctttttttg aaacctttgc taagacaggt
    34141 caagacatga tttttactat tgtaattgac ttcaatgatc caaatgatgt agcaatgctt
    34201 gaaaagattc aggctgtttt tcagtcttat gaccaagagg ttctctttgt cgaattaaaa
    34261 acagatatag aggaacgtct tacacgcaat cgcacagaaa atcgtctcaa acataaacct
    34321 cttaaacgca acatcgagtg gtcagaacaa gatattcaat ccacgatggc atatgctgtt
    34381 tttaatccag aagaaccacc caaaacgctc acgcattacc aaaaaatcaa taatacccat
    34441 ctcaccgctg ctgaaacagc gcagcttatt atccaaaaaa tgactcatat caaggagaac
    34501 taagatgaca gaactatcac ctaaatacaa tcctgccgag gttgaggcag gtcgctatca
    34561 aaaatggctt gatgcagatg ttttcaagcc atcaggagac caaaaagcaa aaccgtattc
    34621 tatcgtgatt ccaccgccaa atgtgactgg taagttgcac ttgggacatg cttgggatac
    34681 gacgcttcaa gatattatca ttcgtcaaaa acgcatgcag ggctttgata cgctttggtt
    34741 gccagggatg gaccatgcag ggattgcgac acaggctaaa gtcgaagaac gtttgcgtgg
    34801 tcaaggcatc acccgttatg atttgggtcg tgacaaattc ctagacaagg tctgggagtg
    34861 gaaagacgaa tatgccacta cgattaaaga acagtggggc aaaatgggtc tttctgtgga
    34921 ctacagccgt gagcgcttca cccttgatga gggcttgtca aaagcagttc gcaaggtttt
    34981 tgttgacctc tacaaaaaag gctggattta ccgtggtgaa ttcatcatca actgggatcc
    35041 tgctgccaga actgcccttt ctgacatcga ggttatccac aaggatgttg agggagcttt
    35101 ctaccacatg aactatatgt tggaagatgg ctcacgcgcc cttcaagtgg caacaacgcg
    35161 accagaaacc atgtttggag acgttgccgt tgccgtaaac ccagaagatc ctcgttacaa
    35221 agatttgatt ggtaaacatg ttattttacc aatcgtgaat aaattgattc caatcgtggg
    35281 agacgagcat gccgaccctg aatttgggac tggagttgtg aaaatcacgc ctgctcatga
    35341 ccctaatgac tttgaggttg gtcagcgtca taacttacca caagtcaatg tcatgaacga
    35401 tgatggaacc atgaatgagt tagctggcga ctttgcaggc atggaccgtt ttgaagctcg
    35461 tcaagctacc gttgctaaac ttgaagaact tggtgcccta gtaaacatcg aaaaacgtgt
    35521 tcactcagta ggtcactcag aacgttctgg tgcagtcgtt gagcctcgtc tatccaccca
    35581 atggtttgta aaaatggatg agcttgctaa acaagctatg gacaaccaag aaacagatga
    35641 ccgagtagat ttctacccac cacgctttaa tgataccttc cttcaatgga tggaaaatgt
    35701 ccatgactgg gtaatctctc gccaattatg gtggggtcac caaattcctg cttggtacaa
    35761 tgcagaaggt gagatttacg ttggcgaaga agcaccagaa ggtgatggct ggactcaaga
    35821 tgaagatgtt cttgacactt ggttctcatc tgctttatgg ccgttctcaa ctatggggtg
    35881 gcctgacaca gatgtagaag atttcaaacg ttatttccca acctcaacct tagtaacagg
    35941 ttatgacatc attttcttct gggtgtcacg tatgattttc caatcgcttg aatttaccgg
    36001 gcgccagcca ttccaaaatg tcctgattca cggtcttatt cgtgacgaag aaggacgcaa
    36061 aatgtctaaa tcattgggga acgggattga tccgatggat gtcattgaga aatacggtgc
    36121 cgatagctta cgttggttcc tctcaaacgg ctctgcccca ggacaagacg tgcgtttctc
    36181 atacgaaaaa atggacgcct cttggaattt cattaataaa atttggaaca tttctcgcta
    36241 tatcctcatg aataatgaag ggttgacatt ggaagatgct gaaagtaatg tggctaaggt
    36301 agctgcttca gaagctggaa atgtgactga ccagtggatt ctccacaatc tcaatgaaac
    36361 catcgctaaa gtgacagaaa actttgacaa gtttgagttt ggtgtggcag gacacattct
    36421 ttacaacttc atctgggaag aatttgccaa ctggtatgtg gaattgacca aggaagtgct
    36481 atatagcgac aacgaagctg aaaaagttat cacgcgctct gtccttcttt atactttgga
    36541 caagattgta cgtctccttc acccaatcat gccatttgta acagaagaaa tttacgctca
    36601 atatgcccaa ggttctattg tgacggtgga ctatcctgtg gttcgcccag cttttgaaaa
    36661 tgaagctgcg cataaaggtg tggaaaggtt gaaagacctg attcgtgcag ttcgtaatgc
    36721 gcgcgctgaa gttaacgtgg caccatcaaa accaatcacc attttggtga agacagcaga
    36781 tagtgagttg gaagacttct tcaccagcaa cgtgaactac atcaaacgtt tcaccaatcc
    36841 tgaaaaatta gaaatcagct cagccattgc tgcgccagag ctggctatga ccagcatcat
    36901 cacaggtgct gaaatctact tgccactagc agatttgctt aatgtggaag aagaactcgc
    36961 tcgcctagat aaagaactgg ctaaatggca aaaagaactg gacatggtcg gcaaaaaact
    37021 cggaaacgaa cgctttgtag ccaacgccaa accagaagtc atccaaaaag aaaaagacaa
    37081 acaagccgac taccaagcca aatacgacgc aacccaagaa cggattgcag agatgcagaa
    37141 aattaaatca tagtgtttag aacgcagttg aaaaactgtg ttcttttctt actaatagag
    37201 atattagatt gaagtttaat tatgagaaaa acgctttctt tatttaaaga gttatgttac
    37261 aatactatta caatcatcgt acaaatagtg ttattttgag gggcatatga gaatgatttt
    37321 agcacactat gactgtaaaa aagataaaaa gcaatcttta gatgagcatt tatggcatgt
    37381 ggcctgttct agtcgacagg aagcatctat aattggtcaa ggagatgtgc tttttttaat
    37441 tggtctttac cacgacctgg gcaaagctga tcgaaccttt caagataaat tattaaataa
    37501 tccaaatcgg catgttgatc actcttatgc aggggcaaaa tacttatgtt ctattattgg
    37561 gcctcatcta aaaaaccgag gggttgataa aaatgagaga atgacattca acgaaatggt
    37621 ggggtatgtc atctctgctc atcatgggat gtatgattta tgctactatt ttgacgatgc
    37681 tgaatattat ggctttaata agtttaaaaa tcgtatcaat agagacttag atggttatca
    37741 ctatcatgaa gatattaaag ggtacgctct aaaattagaa aaaaaattat gtgattatgg
    37801 ctacaaagat ttaagggagc ttattgataa agcttttgat aattaccaac aagccatgtc
    37861 ttccttaaac tggcaagata agagtgagtg ggattattat cagtcttgta tggtgagact
    37921 ttacttgtca ctcttaaaaa acgctgatat tttggacaca gtaaatgcct atggccttaa
    37981 gataagtcct atggataaaa cagagcgatc ctttctaaaa cactcctatt tagcggccat
    38041 tgaacaaaaa tatgctagct ttggacagcc aaacaatcag ttgaacacta ttcggacaga
    38101 aatcgctgag cgtgttaaag aaagaggtaa acgagattcc aaggggattt atcgcttaga
    38161 tttaccgaca ggagctggca agactaatct tagtatgcgt tatgcgtttc accaattagt
    38221 tcatcacgac aaatcaaggt ttttttacat aacgcccttt ctttcggttc ttgagcaaaa
    38281 tgcttccgaa attagaaaag ttacaggtga ccttggcgtt ctagaacacc attccaatgt
    38341 ggtgaaacag gctaatgaag aagatgatga caaggacagt ttattgtcag cttatcttag
    38401 tgatagctgg gacagtcaag tagtcttgac ttctatggtt caatttttcc aaacactttt
    38461 caaaacaaaa tcagctaatc tgagacgttt ttcaagtttg attaatagtg ttgtgattct
    38521 agatgaagtt caatccctgc ctattgaagt caccactttg tttaatttaa cgatgaattt
    38581 tttaaataaa gttatggata caaccatcgt tctttgcaca gcaacacaac ctgcttatga
    38641 ttcttcagag attgaccatc gtatctgtta tggagggaac ttgggagaat tagctgaaat
    38701 cgttgagtta acgattgaag aaagacagat tttttcaagg acagagctta gaaaatttga
    38761 tgataatgat cagaaagttc acttgactga tgttattaac cttattctag gtgaggaaaa
    38821 ctcagttctt gctattttta atacgaaaaa aatggttcat aactgctata ctatgctaaa
    38881 agacatgact gatagaccgg tctatcagct ttcgactcaa tctacgacta tttaagcctt
    38941 aatatttatc agacagcaaa taaaaagttc aaaggtaagt taaaacaagc ttttaaaaca
    39001 gcaggagcca aaatgaacct catcaataat gacatgatag gaattctcgt accttatggc
    39061 gaagctgaga aaaaattggc ttatttagaa gaattgggta tgtctcattt tttatcagca
    39121 gaagattatc aaacgataaa atcattacta aaagagttac aaccttttac ggttaatgtc
    39181 cgcgagaacg atcctctctt tgagacaaca aaatcttatc taaatggtca gattctggtt
    39241 ttgacgtcgg agtattatga cacggaaaga ggagttaaat acgattcagc tagcttttac
    39301 ttctaactca aaacgaaagc agattaacaa aaggttgtta gaggaccttg ttaacctgcc
    39361 aatcatcatt aataattatt atcaatttag actatttaat aaaattagat tacaaaaaaa
    39421 cagaaggagg aaagtagctt gtacagatct agagacttct acgtgagagt aagtggtcag
    39481 cgagctcttt ttacaaatcc agcctcaaaa gggggatcgg aacggtcatc ctattcggtt
    39541 ccgactagac aggcactgaa tggtatcgtt gatgccatct attataagcc gacctttact
    39601 aatatcgtca cagaggttaa ggttattaac cagattcaaa ccgaattaca gggtgtcagg
    39661 gctctgttac atgattatag tgcagattta agttatgtat cctatttgag tgatgttgtt
    39721 tatctgatca agtttcattt tgtttggaat gaagatagaa aagatttgaa ctcagataga
    39781 cttccagcta aacatgaagc cattatggag cgttctattc gtaaaggggg acgtcgagat
    39841 gtgtttttgg gtacaagaga atgtttaggg cttgtagatg atatcagcca agaagagtat
    39901 gagactactg tgtcgtatta taatggtgtc aatatcgact tgggaatcat gttccattcc
    39961 tttgcctatc cgaaggacaa aaagacacca ttaaaatcat actttacaaa gactgtgatg
    40021 aaaaatggag tcattacgtt taaagcacag tctgaatgcg atattgttaa cacgctttct
    40081 agttatgctt ttaaagcacc agaggagata aaatcggtta acgatgaatg catggagtat
    40141 gatgccatgg agaaaggaga aaactgatgg atttttttac ttctctcttg aagacttatg
    40201 aaaaagcaga gctagcagac ttggttgatc atcaaaaaag aagtaatgag ccggttttac
    40261 tgccgattta tcatacgagt ttaaagtcaa atggcaaaaa tatcatttca gtgaaacttg
    40321 acaaagatgg ccagtttcac aaggcagaat ttatggcaga taagcaaatg attatttttc
    40381 ctgtaacggc tgattctgtt gctaggtcag gtagtcatcc tgcaccgcat cccctagtcg
    40441 ataaatttgc ttattatagt gctgaaatgg ggcagtccca gtatgattct tttcataagc
    40501 aacttaataa ctggattgat tattgtgagg agggtgacgt caagaggttt ttaaccattg
    40561 ttcagcaatt tattttgaaa ccagaatttc tgacattgat tcttgattct ttaattgctc
    40621 ctgattatca acataatcaa ttaaaagtca tctattttga tgctactgga aaagaaaaac
    40681 taattgattt atcagcttgc tttttagaat tttcaattga ccaatttcag ggctttaaaa
    40741 atgaatcggt ttcgacgttt aaagctttac accaatccta tatttctttt gttgaagcca
    40801 atcgtgaaaa tctcggtatt tgtaatatta gtggacgaga ggaacagctt accgataagc
    40861 atagaggttt gatggggaat gctaaaatca tctctgttag taataaaaga gaagcttata
    40921 aaggacgttt tagagaacgc gaagacgttt ttagtgttgg ctatgaaact tccgaaaaga
    40981 ttcatttaat gatcaagtat cttttagaaa ataaaaatac cagtacttgg ttagggtctt
    41041 ctcaatattt aatcaactgg ttcagcgatg atttaacaaa tgatagtcgg ttggatattg
    41101 tatcaccaat ctttgatgat ggacttgaag aagatgatga tgacgatacg cctcctgtta
    41161 taacattagc aactgaagac aataaaagaa ttggtaaatc attcatcaag ggacaaaaat
    41221 tatttgctaa tgatgccact tactacgttg ctattttgaa taaaaccagc aatgggcgga
    41281 ttgctttaaa atattttcgt cagcttcaag cgtcccaatt actcaccaat cttaacaagt
    41341 ggcaggaaac atacagttgg gagtcgcgat ctaagtttgg aaaaagtcgc ttaagaaccc
    41401 ctacttttca tgacatcctt aatgtgtcct acggggttga tagggatcgc ttccttgaat
    41461 tagataatga taacttcaaa agtgatcaaa ttcaaaagtt agtggcaagt ttgattgatg
    41521 gtaaaccgat gccacagtcc attgtcaaaa agttaggtaa caatgttaaa gaacgacatc
    41581 gttaccgtaa gcactggtat caagttgagc aggtctgctt agcaatttta cacaaacaaa
    41641 atggggagga attttcaccg atgctagatc ataccaatca aaatcgttcc tatctttttg
    41701 gacgattatt agcaattttt gaattaatcg agaccttgcg ttatggcttg gatggaaaca
    41761 ataacgaccg tattaccaat gctgaacgtt attggacagc ctatactgga caaccaacaa
    41821 aattgatgat gttattggaa aataaaatta agccttacga agaaccattg aaattaaatc
    41881 gtcgtggcag ttggatgaaa ttagaaaaag aaaaagaaga gattttagaa ctgttaaatc
    41941 ctctgttaga aacagaaaca atggaaaaac ccttagatta ccgctttatt tttgggtatt
    42001 atgctgagaa aaactattac tatacaaaac aaaacactga agtaacagaa agtgaggagt
    42061 aaaaagatgt tggaacacaa aattgatttt atggtaactc ttgaagtgaa agaagcaaat
    42121 gcaaatggtg atcccttaaa tggaaacatg cctcgtacag atgccaaagg atatggtgtg
    42181 atgagtgatg tctccatcaa acgtaagatt cgtaatcgtt tgcaagatat ggggaagtct
    42241 atttttgtgc aagctaatga acgtattgaa gatgactttc gttcactaga aagacgcttt
    42301 tcacaacatt ttacagctaa gacacctgac aaagaaattg aagaaaaagc aaatgcatta
    42361 tggtttgatg ttcgtgcttt tggacaagtt tttacttatc tgaaaaaatc aattggggtg
    42421 cgtggaccag tttccatcag tatggctaag tccttggagc caattgtcat ttccagcctt
    42481 caaattacgc gtagtaccaa tggtatggaa gctaagaata atagtggccg ctcttctgat
    42541 acgatgggga caaaacattt tgtagattat ggtgtgtatg tacttgaagg ttctatcaat
    42601 gcttattttg ctgaaaagac tggtttttct caggaagatg ctgaggctat taaagaagtt
    42661 ctggttagct tgtgtgaaaa tgatgcgtcg tctgcacgtc cggaaggctc tatgcgagtt
    42721 tgtgaagtct tttggtttac gcattcaagc aaactgggga atgtttcaag tgcgcgtgtc
    42781 tttgacttgt tagagtatca tcaatcaata gaagaaaaaa gcacttatga cgcttatcag
    42841 attcatctaa atcaagaaaa attggctaaa tatgaagcga aagggttaac ggttgaaatc
    42901 ctagaaggac tctagtatgg tctatgccga agatgattat ttaatgctat caggtattca
    42961 gcatttccaa ttttgtaaac gtcaatgggc gttgatccat attgagcaac aatggcttga
    43021 taatgaagcg acagcgcatg gacaggtttt acatactaaa gcagataacc cttacattaa
    43081 agaaaaacga aaagagcttt tggtctcacg tgctatgccc atttcttctg cagaacttgg
    43141 actttcagga attatggatg ttgtggaatt ttataaagat gatcaaggtg tgtctttgag
    43201 gggaaaacgt gggaaatggt taccaaaagt tgtggaatac aagcgcggaa aacctaaaaa
    43261 agataccaga gatattgtcc agttggtggc tcagaccatg tgtttagaag aaacgctaga
    43321 ctgcgacatt aacgaaggtt gtctttatta ccatagtgtc aatcaaagag tgattgttcc
    43381 tatgacatca gctttgcgtc aagaagtgaa ggaattagcc gcagagatgc aagaggttta
    43441 tcagagtcaa atgctaccta aagcagctta ttttaaaaac tgtcagcttt gttctttagt
    43501 cgatatttgt aagcccaggt tgagtaaaaa aacaaggagt gtgtcgcgtt acatcaatga
    43561 ggctatgacc agtgaggaga tggacctatg aaaaagttgc taaatacctt gtatttgacg
    43621 caagaagatt tttatgtcac taaagagggc gataacattg ttatcaagca agaaggtaag
    43681 gttctcaaac ggtttccgtt tcggattatt gacggtattg tctgtttttc ttatttgggt
    43741 gtgtcgcctg ctttggtgaa gttatgtacg gagaatcaga ttaatttatc gtttcataca
    43801 ccacaagggc gtttttgtgg tcgctatatt ggttcaacca atgggaatgt gttgttgcgt
    43861 agagaacatt atcgtttatc tgatcgtgag gaatctttgg aatacgcaaa gcggtttatt
    43921 ttggctaaaa tttccaactc aaggaaatac ttgctacgct ttaaacgaga tcatcgtcaa
    43981 cagattgata ccaagctttt tgaggctgtt aatgacgaat tgatatgggc tttagagatg
    44041 gttcaggcag cagataataa agactcttta agagggattg aaggccaagc tgctaatcag
    44101 tattttcgca tatttaatga cctggtgttg acggacaaaa aaacgtttta cttccaaggt
    44161 cggagtaaac gaccaccctt agattgtgtt aatgccctct tgtcttttgg ttacagttta
    44221 ctgacctttg aatgtcaatc tgccttggaa gctgtcggat tagacagtta cgttggtttc
    44281 tttcacacgg atcgtcctgg gtgtgctagt ttagcgcttg atttagttga agagttccgc
    44341 tcatatattg tagatcgttt tgtcttttca ttaattaata aaggacaact tcagaaaaaa
    44401 cactttgagg ttaaagaaaa tggtagtatt ttaatgacgg aaaatggcag agctattttt
    44461 attgatttgt ggcagaagcg taagcatact gaggtagaac atccttttac aaaagagaaa
    44521 gtaaaactta tgttattacc ctatgtacaa gcgcagcttt tagctaaggc catacgagga
    44581 gatttagaaa gctatccacc ttttatggtt taggagatgt tatatgatgg ttttagtcac
    44641 ttatgatgta aatacggaaa cacctgctgg tagaaaaaga ttgcgtcatg ttgccaaact
    44701 ctgtgtggac tatgggcaac gtgttcaaaa ttctgttttt gaatgttctg tgacacccgc
    44761 agaatttgtg gatataaagc accgcttaac acaaatcatt gatgagaaaa ctgatagtat
    44821 tcgcttttat ttattgggga aaaattggca gaggcgtgtg gaaacacttg gtcgctcaga
    44881 cagctatgac ccagataaag gtgtcttatt attgtaaaaa tctcttgtgc gaagctagct
    44941 ttcacagaaa caccttgctt gctcgcgcaa aaataactta aaaaagaagc gaaatggaga
    45001 taaaaaggct taaaacacct ctatgtgtgc catccgtttc tctataaact gtgtcatttg
    45061 gcgcagtctc acccttcatg ggtgagtgga ttgaaattac tagcgttgag atagccggta
    45121 ttaatcttac cgtctcaccc ttcatgggtg agtggattga aatatttcgt cacctcctca
    45181 atcaataata gagtcagtct cacccttcat gggtgagtgg attgaaatct aagatgatac
    45241 cagttacaat accgatttta agcgtctcac ccttcatggg tgagtggatt gaaataaata
    45301 attacatgac tagccaatac acccacatag tctcaccctt tatgggtgag tggattgaaa
    45361 tttcatgagc ttctttactc tcaaagtaag agtggtctca cccttcatgg gtgagtggat
    45421 tgaaagatga acccgatctc tcttttaatg aggtcgggtt tttacatgcc tttagtcaac
    45481 catttatctg atagcgtatc aaattcaagt ttttgcatgt tctagtctat ggtttgcgcc
    45541 actagctttc ggtaaactaa gggtaactta agagaggagt tatttatgac actatcactt
    45601 gtattaatgg tatcggtttt tggggcaggc ttgttatcct ttttctctcc gtgtatcttt
    45661 ccggtccttc ctgtttattt aggcatttta ctggatgcag atgattcaaa gacgattact
    45721 atatttgata aaaaactcta ttggtatggc attgtcaaaa ccttagcctt tatttttggt
    45781 ctatctacta tttttgtgat tttaggttac ggggctggtt ttttaggaaa tatcctttat
    45841 gcggtatggt ttcggtactt actgggagcc ttggtcatta tcttggggat tcatcagatg
    45901 ggcctcatta ccattaagag cttacaattt caaaaatcac tgactttcca taataacaag
    45961 aatcgcaacg gtttgttcaa tgcatttatt cttggtttaa cctttagctt tggttggacg
    46021 ccttgtgtgg gacctgtttt gagttctgtt ctagctttgg tggcttcagg gggaaatggt
    46081 gcctggcaag gtggcgtttt gatgattatt tatactcttg gattgggcat tcctttccta
    46141 ctcatctctt ttgcgtcagg cattgttttg aaacagttta acaagctcaa accccacatg
    46201 cttttactga aaaaagtagg aggtgttctg attatagtca tgggaatctt gcttatgaca
    46261 ggaaccttaa ataacttagc acaacttttt ggataaagga gaaacacaat gaaaaaagga
    46321 ctattagtaa caactggttt ggcttgtctc gggctactaa ctgcttgctc aacccaagac
    46381 aatatggcta aaaaggaaat aactcaggac aagatgagca tggcagctaa aaagaaagat
    46441 gagatgtcaa catcaaagga caagtccatg atggcagata aaacatctga taagaaaatg
    46501 accaatgatg gtcctatggc gcctgatttc gaactcaaag gcatcgacgg taaaacttat
    46561 cgcttatcag agttcaaagg taaaaaagtt tatttgaaat tttgggcctc ttggtgttca
    46621 atctgtctat caaccttggc agataccgaa gacctggcta aaatgtcaga taaagactat
    46681 gtggtcctaa cagttgtctc gccaggtcat caaggggaaa aatcagaagc agactttaca
    46741 aaatggttcc aaggaacaga ctataaggac ttaccagtct tgttagatcc ggatggcaag
    46801 ctattggaag cttacggcgt cagatcttac ccaacagaag ttttcattgg aagtgatggt
    46861 gttcttgcta aaaaacacat tggttatgcc aaaaaatcag acatcaaaaa gacccttaaa
    46921 ggtatacatt aggaaggacc agctgatagg cattagaaaa aaggagttga gtttatggaa
    46981 cacaaatgga aattatggct atttatcgtt ggagtggtct tgttaatagg cggagcttct
    47041 gttctcattc agaaaggtca agccaaggct tttagtcaag gcaagcctca actaccagct
    47101 aaaaaagtca aatccactaa agtagatccc aatgcccctg ttgatcaaaa aatgatttac
    47161 ctagctggtg gctgtttctg gggcgttgaa gaatattttt cacaagtgga tggcgtctta
    47221 gatgcggtgt caggatatgc caatggtaga ggcgatacca ctaattacca gttaattcat
    47281 cagactggtc atgcagaaac cgttgaagtg gcctatgatg cgaaccgtat tagcttgaaa
    47341 gaattattac tgcatttttt ccgaattatt gacccaacca gtcttaataa gcaaggaaat
    47401 gatcgcggta gtcaataccg aactgggatt tactatactg acaaagcaga tttagctatt
    47461 attgatgagg tcttcaaaga aaaagctaag gattacaaga aaaaaatagt ggttgaaaag
    47521 gcgccattga aacactttat taaggccgaa gagtaccacc aagattacct caagaaaaat
    47581 ccaaatggct actgccatat tgacatcaac caagcgacct atcctgtgat tgatgaaagc
    47641 aagtacccca aaccaagtgc cactgagatc aaagcaaaac tatctgcaga cgaataccga
    47701 gtgacgcaaa aaaacgaaac tgaaaaagct ttttctaatc gctactggga ttcttttgat
    47761 gcaggaattt acgtagacgt tgtgacagga gaaccgcttt tctcttcaaa agacaaattt
    47821 gaatcaggtt gtggttggcc aagctttagc cgccccctca gcccagacgt tgtccgctac
    47881 aaggaagata agagtttcaa tatgacgaga acagaagtgc gcagccgttc agggaattct
    47941 catctggggc atgcctttac tgacggacct aaagaccaag gcggccttcg ttactgcatc
    48001 aatagcttgt ctattacctt tattccaaaa gctgatatgg aagctaaggg ctatggttat
    48061 ttattatcat ctgtagaata gggttaggcc taaaaatctg atataataga agaaagacta
    48121 gtatgagagg accatgcaag gccctttata aagataagga gacaccgtgt gtactcattg
    48181 ttaattgtag aagacgaata ccttatccgc caaggtattc gttctttggt tgattttagc
    48241 cagttcaaga ttgatcgggt caacgaagca gaaaatggcc agttggcttg ggacttgttt
    48301 cagaaagagc cttatgatat tgttttgacg gatatcaata tgcccaaatt aaatgggatt
    48361 caactggcgg agttgattaa agagcatgcg cctcagaccc atttggtttt tttaaccggt
    48421 tatgatgact ttaactatgc tttgtctgct ttgaagttag gggcagatga ttacttgctc
    48481 aaaccctttt ccaaggccga tgtagaagac atgttaggaa agctccggaa aaaattagac
    48541 ctttccaaga aaacagaaac cattcaggaa ttggttgagc agcctcaaaa agaagtatca
    48601 gcaatagcaa tggctattca tgagcagttg gcagattctg atttgaccct aaaaagcttg
    48661 gctcagcagc ttggttttag ccctaattac cttagcgtct tgattaaaaa agagttaggg
    48721 atgccctttc aagattatct ggtacaagaa cggttgaaaa aagccaagct tctcttgtta
    48781 accagtaatc ttaaaatcta tgaaattgca gagcaggtcg gttttgagga tatgaattat
    48841 ttttctcagc gctttaagca actggtaggc gttaccccaa gtcagtataa aaaaggaggc
    48901 caggcatgaa gcgttatccc ctactggtcc agttgatttc ttatgtcttt gtgatcgtaa
    48961 ttgccctcat taccacgctt ggtttgcttt attaccagac gagttctcgt aatatcaggc
    49021 aattaattga acgtgatacc cggcagagca ttcggcaaag ttcccaattt attgacgctt
    49081 acatcaagcc tcttaaagaa acaatttcgg tgctggcgaa aaattcggaa attaaagact
    49141 ttgctagtca aattcatcaa gaaaatgaca aacaggtttt tcagctcatg aagatggttc
    49201 ttgcgaccaa ttccgattta caagcagctg ttctggtgac taaggatggc cgaaccgttt
    49261 ctaccaatcc tcagttgatt atgaaaacct ccagtgatat gatggcagaa ccctggtata
    49321 aagcagccat agaccgtcaa gccatgccaa tcttaacccc agctcggcaa ttatcccttt
    49381 cttctaaaaa agaatgggta gtttctgtga cccaagaggt agtggatgct gttggtcata
    49441 atttaggcgt gctaagactt gatattgcat acccgaccat taaagcgtct ttagatcagc
    49501 ttcagctagg ccgccaaggc tttgccttta ttgtgaatga taagcatgaa tttgtttacc
    49561 atcccaaaaa gagtgtttac agttcttcta aggagatggc tgcgatgaag ccttatttag
    49621 cgattcagaa tggttacact aaggacaaga catcttttgt ttaccaaaaa ctcattccta
    49681 acagtcaatg gactttagtg ggagtggcgt cactggatca gttgcaccgg gtgcagcgcc
    49741 aaattttttg gtccttcctt ggaacagggc ttctagcctg tctgatttgt agctttgcaa
    49801 ctgtcttagc cttacgcaga tggattcgtc ccattcaaca attgcagcaa gttattcttg
    49861 ctattcaaaa aggagatcgt cagttacgtg cccaagaaac gggttctcca gaattgacag
    49921 accttgtcca acagtttaat gcgctcttag atcaaattga tagcttgatg gttgccgttg
    49981 cggataagga aaaggcgatt gggcagtata ggttacaagc cttggctagt cagattaacc
    50041 cgcattttct ctataacacc ttggacacta ttatttggat ggcagaattt aatgacagca
    50101 agcgcgtggt agaagtgacc aagtctctag ctaagtattt tcgtttagcc cttaatcagg
    50161 gaaacgaata cattcgtttg gcagatgaac tggatcacgt tagccaatac ctctttattc
    50221 aaaaacagcg ctatggagac aagctaagtt atgaagtgca aggcttagat gtctacgcag
    50281 actttgttat tcctaagctt atcttacagc ccttagtaga aaatgctatc taccatggca
    50341 tcaaagaagt cgatcgcaag ggcatgatca aggttacggt atctgataca gctcagcatc
    50401 tgatgttgac tgtttgggat aatggtaaag gcattgaaga ctcttcactg accaatagtc
    50461 agagcttgtt ggctagggga ggtgtgggcc ttaaaaatgt tgaccagcgg ttaaaacttc
    50521 actatggtga aggctaccac atgaccattc atagccagtc agaccagttc actgaaatac
    50581 aattaagcct tcctaaaatg catgaattaa tggcagacga cacacaggaa aacgagtaag
    50641 gttacaggaa gtgcatgtca gccatttccc taagttaggg tattggagat aagaacctta
    50701 gaaaggatat catgagttta gcatctgact attttagccg acagaccccc atagttgaaa
    50761 agctaatggc ttacggtttt gaaaaacgaa ataatggtta cttctataac gaacggttta
    50821 tggaagaaga atttgaggcg cagcttagga ttgatgaggc tggcaatatc tgggatcggg
    50881 ttattgattg tgacttggag gaggattatt tgcctttaca acaagcagcc tggcaaggaa
    50941 cctatactgg gcaggttaga gcggcctatt tggaactttt ggagcgctta tcagtagcct
    51001 gttttgaagc cactcctttt cagtcaatgc aagctaatag acttgctaag catatcacca
    51061 aagaatggtc tgacccaatg gactatcctt ttgaaaagca cccagacctt gcaacctatc
    51121 gggtaggggg caaatggtat gctatgattt tttctctctt ggctgataaa ttagaccaga
    51181 taccagagag attagtagga cagacatgtg aagtgatgac tgtcaaagtt aatcccaagg
    51241 atttacctca gttactgcag caagaaggca tttacccagc gtatcacatg tcaaagaaaa
    51301 actggattag tattattttg gatgataaga taacagatga taagctttgg acgttagtga
    51361 ctcaaagtcg tcaactagtc aacccaaacg gtctttctaa tcctaatggt cctgattatt
    51421 gggtcattcc agctaatttg aaatactatg atattgatgc agaatttgca gccaatgatg
    51481 ttattttatg gacccaaaaa gctggtattg ccgtgggaga ctacgtgttg atttatataa
    51541 cagccccagt caaatccatt cgctatgtct gccaagttct agaaactgat atacctaacg
    51601 agggttatcg taaaaatcct aacattgaca aactcatgcg tctccgaaaa tgccaacagt
    51661 acaaggatgg tctcttgtcc tttgacctta tgaaagaaca tggcgtagct gcagtgagag
    51721 ggccaagacg attaagccct caattaattg catttttaaa ggaaaaagag tattttaaag
    51781 agaacaacta aaggagaata agagatggtt gaatttgtag cagatcaaag tttttgggaa
    51841 ctttttccag atgccaaact aggtgtcgtc ttattaaagg atgttcagaa ccaagcagag
    51901 tcaccagaag atgtcaaaca gctcttagca gacagccatg agttagcaaa agcttattta
    51961 acagcagaca attttagtga taatcaggtg gttcaagtct accgcaaggc ctatcaacac
    52021 tttaaaacca aaaaaggagc tcgctctagc attgaagccc ttctcaagcg ggtgtcaaat
    52081 ggtcaaagca ttccgtctat taacccacta gtggatattt ataatgcggc tagtctacgt
    52141 tttggtttac ctgctggagc cgaagatagt gacagtttta tcggagattt gcgtctgacg
    52201 ataacagatg gtggtgacga cttttacttg attggggatg ctgacaacaa ctcaaccttg
    52261 ccaaatgaac tctgttataa agatgatatt ggagcggttt gtcgttgcct taactggcga
    52321 gatggcgaac gcaccatggt gacagaacac accaaaaatg catttctgat tatcgaagct
    52381 cttgatcaag aaggtcaaaa tagattgcaa gaagctctga aattcattga aggcagcgca
    52441 aaaatgtacc ttcatgcaat cacttctgtg catgtgttgg ataaagacaa tccacacgtg
    52501 ccacttttta cagaaaacta gattagtagg atgagctgtg taaaatagaa ggttaacaaa
    52561 aaaagcgagt aaacgaatgt cctgtcattt aggttttcgt ttactcgctt tttgatgaga
    52621 ttttactgct gtcctagcaa aaggtgagga tgaggtcgta tatcacatag aggttttctg
    52681 ttaagcctta tttgttacta aagaagaatg gtggtgtgta atgactaaga gtctcgtaac
    52741 aagccttggc ttgctcattg tcttcacaga caatcaagca agtatcatca ccacagatcg
    52801 ttgctacaat ttctggaatt tgcatggcat ctaaaatgga gccaaaggat tgggctagtc
    52861 caggtaacgt ttttaaaata atttgatgtt gaactatctt taacatgacc aaagcgtctt
    52921 ccatgtaaaa acgaagacga tgttcccagc gggtttgtga aatggctaac gcttcatagt
    52981 gtgtgtcgtt tccagaagtt actttgacca ggttcaattc cttcatgtca cgtgataggg
    53041 tagcctgagt gatcgtgatg ccattttttt gcaaccgttc ttgtaattct tgctgtgtat
    53101 gtatagttgt ctcagagatg agggaacgta tgagttggtg acgcgtctct ttcttattca
    53161 ttgttataat cttcctttaa cgtaattgat aacaatccga gtatagcaaa aagaggagaa
    53221 ggtgtaaagt ttttgatgaa ccgcttacaa aatggctttt ttatggtaaa ataaagatga
    53281 tgtttagaaa aaggagattt gtgtgattcg aagagaagat tatcaatacc ttagaaaact
    53341 aaacgatttt cgctactttt ctattgaaca atttgacaaa attgtagggc agatggaatt
    53401 ccgaaaagct aaaaaggacc atatcctttt ttttgaggga gataaaagag ataagctttt
    53461 tctagtgacc tctggttatt tcaaggtgga gcagtccgat caatcaggaa ccttcatgta
    53521 tacggatttc atcagacacg gcaccatttt tccttacggt ggccttttta cagatgatta
    53581 ttaccatttt tcagtggtag ccatgacaga cgtgacttat ttttactttc cagtcgattt
    53641 atttgaagat tactcgcttg aaaatcgtct acaaatgaaa cacttatata gtaagatgtc
    53701 taaactgctc gagttacatg agttgagggt ccgaaacttg attacatcaa gtgctagttc
    53761 tcgtgtgatt caatctctgg cgattttgct ggttgaaatg ggtaaagaca gtgatacctt
    53821 accttttcaa ttaacaacaa cagatattgc tcaaataagt gggacgacaa gagaaacagt
    53881 tagccatgtg cttagggatt tgaagaagca agaattgatt accataaaag gtaagtattt
    53941 gactta
//
LOCUS       DAUDWO010000008        53533 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.008, whole genome shotgun sequence.
ACCESSION   DAUDWO010000008 DAUDWO010000000
VERSION     DAUDWO010000008.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 53533)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 53533)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..53533
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.008"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(292..1629)
                     /gene="pepC"
                     /locus_tag="VHC05_000424"
     CDS             complement(292..1629)
                     /gene="pepC"
                     /locus_tag="VHC05_000424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase C"
                     /protein_id="HEQ5401763.1"
                     /translation="MSALTETFTEQLFAHYEANAKFSAIENAVTHNGLLKSLETRQSE
                     VDNDFVFSIDLTKDKVSNQKASGRCWMFAALNTFRHKLITEFKLENFELSQAHTFFWD
                     KYEKANWFMEQVIATADQELTSRKVKFLLDVPQQDGGQWDMVVSLFEKYGVVPKSVYP
                     ESISSSNSRELNQYLNKLLRQDAQILRDLIASGAKADQVEDRKAELLQEIFNFLAMTL
                     GLPPRHFDFAYRDKDDHYHVEKGLTPQAFYDKFVGLKLSDYVSVINAPTADKPYGKSY
                     TVEMLGNVVGSREVRYLNLDMKRFKELAIKQMQAGESVWFGSDVGQVSDRQKGILATN
                     TYDFEASMDINLSQDKAGRLDYSESLMTHAMVLTGVDLDETGKPLKWKIENSWGEKVG
                     DKGYFVASDAWMDEYTYQIVVRKEFLTADELAAYEKEPQVLAPWDPMGALAQY"
     gene            complement(1814..2638)
                     /gene="nadE"
                     /locus_tag="VHC05_000425"
     CDS             complement(1814..2638)
                     /gene="nadE"
                     /locus_tag="VHC05_000425"
                     /EC_number="6.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003052203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ammonia-dependent NAD(+) synthetase"
                     /protein_id="HEQ5401764.1"
                     /translation="MTLQEEIIRQLGVKASIDPQEEIRKTVDFLKAYLRKHSFLKTYV
                     LGISGGQDSTLAGKLAQMAIAELREEASDQAYQFIAVRLPYGVQADEADAQKALAFIA
                     PDQTLTINIKAAVDGQVEALQAAGVEISDFNKGNIKARQRMISQYAIAGQMAGAVIGT
                     DHAAENITGFFTKFGDGGADILPLFRLNKRQGKALLKVLGADAALYEKVPTADLEDQK
                     PGLADEVALGVTYQDIDDYLEGKLISKVAQATIEKWWHKGQHKRHLPITIFDDFWK"
     gene            complement(2640..4094)
                     /locus_tag="VHC05_000426"
     CDS             complement(2640..4094)
                     /locus_tag="VHC05_000426"
                     /EC_number="6.3.4.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="HEQ5401765.1"
                     /translation="MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFN
                     NGYAVFAGLQRMVEYLEQFQFSETDLAYLEELGYPENFLTYLKELRLELTIRSAKEGD
                     LVFANEPIVQVEGPLGQCQLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRR
                     AQELDAAIWGTRAAMIGGADATSNVRAGKRFDIPVSGTHAHALVQAYGNDYDAFMAYA
                     KTHKDCVFLVDTYDTLKVGVPTAIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLD
                     DAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALGAVYKIVSIE
                     QEDGSMRDTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITFTDINVNELTEIEM
                     FHPTYTYIKKTVKEFDAIPLLVDIFVKGELVYQLPTLAEIKAYAKKEFDKLWDEYKRV
                     LNPQDYPVDLARDVWQNKMTLIDNIRKDTHGKSE"
     gene            complement(4264..5643)
                     /locus_tag="VHC05_000427"
     CDS             complement(4264..5643)
                     /locus_tag="VHC05_000427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HEQ5401766.1"
                     /translation="MSIKEQTDNNELENGMVRGLENRHVQLIAIAGTIGTGLFLGAGR
                     SIALTGPSIIFVYMITGAFMFMMMRAIGEMLYYDPDQHTFINFISKYIGPGWGYFSGL
                     SYWISLIFIGMAEITAVGAYVQFWFPSWPAWLIQLVFLVLLSSINLIAVRVFGETEFW
                     FAMIKILAILALIATAIFMVLTGFETHTGHASLSNIFDHFSMFPNGKLKFFMAFQMVF
                     FAYQAIEFVGITTSETANPRKVLPKAIQEIPTRIVIFYVGALVSIMAIVPWHQLPVDE
                     SPFVMVFKLIGIKWAAALINFVVLTSAASALNSTLYSTGRHLYQIANETPNALTNRLK
                     INTLSRQGVPSRAIIASAVVVGISALINILPGVADAFSLITASSSGVYIAIYALTMIA
                     HWKYRQSKDFMADGYLMPKYKVTTPLTLAFFAFVFISLFLQESTYIGAIGATIWIIVF
                     GIYSNVKFK"
     gene            complement(5812..6729)
                     /gene="trxB"
                     /locus_tag="VHC05_000428"
     CDS             complement(5812..6729)
                     /gene="trxB"
                     /locus_tag="VHC05_000428"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HEQ5401767.1"
                     /translation="MYDTLIIGSGPAGMTAALYAARSNLSVAIIEQGAPGGQMNNTFD
                     IENYPGYDHISGPELAMKMYEPLEKFNVENIYGIVQKIENFGDYKCVLTEDASYEAKT
                     VIIATGAKYRVLGVPGEEYYTSRGVSYCAVCDGAFFRDQDLLVVGGGDSAVEEAIYLT
                     QFAKKVTVVHRRDQLRAQKILQDRAFANDKVDFIWDSVVKEIQGNDIKVSNVLIENVK
                     TGQVTDHAFGGVFIYVGMNPVTGMVKDLEITDSEGWIITDDHMRTSIPGIFAIGDVRQ
                     KDLRQITTAVGDGAIAGQGVYHYLESFPS"
     gene            complement(6793..7017)
                     /locus_tag="VHC05_000429"
     CDS             complement(6793..7017)
                     /locus_tag="VHC05_000429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4059 family protein"
                     /protein_id="HEQ5401768.1"
                     /translation="MLVEIFSLYVKGLILSSLTMILICLIWTLWRAKTKRDKTLIERQ
                     AFLYEMLMVAILTIPILSFAFMSILVVIKS"
     gene            complement(7121..7864)
                     /locus_tag="VHC05_000430"
     CDS             complement(7121..7864)
                     /locus_tag="VHC05_000430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401769.1"
                     /translation="MITIRNLSKTFSGQKVLDSLALDIEKGQVIALVGASGAGKSTFL
                     RSLNYLEKPDSGSISIGDFTVDFETITTEQVLILRRKLAMVFQQFNLFERRTALENVK
                     EGLKVVKKLSDQEATKLAQAELAKVGLADRKHHYPRHLSGGQKQRVALARALAMKPDV
                     LLLDEPTSALDPELVGEVEKSITDAAKSGQTMVLVSHDMNFVYQVADRVLFLDQGKIL
                     EQGTPEEVFRHPQKERTKEFFASYSKTYI"
     gene            complement(7864..8667)
                     /locus_tag="VHC05_000431"
     CDS             complement(7864..8667)
                     /locus_tag="VHC05_000431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEQ5401770.1"
                     /translation="MTSVFLTSGWAFYDHLISPIPHGKLFSWHAVFDAIPNIIQRLPI
                     TLGLTLSGATFGLVLALIFALVKINKVKLLYPIQAIFVSFLRGTPILVQLMLTYYGIP
                     LFLKFLNQKYGFDWNVNAIPASIFAITAFAFNEAAYASETIRAAILSVDTGEIEAAKS
                     LGMTSVQVYRRVIIPNATVVAIPTLINGLIGLTKGTSLAFNAGIVEMFAQAQILGGSD
                     YRYFERYISVALVYWSISILMEQVGRLIENKMAIKAPEQARNEKLGELR"
     gene            complement(8861..10204)
                     /locus_tag="VHC05_000432"
     CDS             complement(8861..10204)
                     /locus_tag="VHC05_000432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008535518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEQ5401771.1"
                     /translation="MSFKDYHFKQYVQQALEEIGFVNPTEVQKRLIPIVNSGRDLVGE
                     SKTGSGKTHTFLLPIFEKLDEAKAEVQVVITAPSRELATQIFDACKQIAKHSQEEIRL
                     ANYVGGTDKLRQIEKLKGSQPHIVIGTPGRIYDLVKSGDLAIHKATTFVVDEADMTMD
                     MGFLDTVDKIAASLPKSVQILVFSATIPQKLQPFLKKYLTNPVIEQIKTKTVIADTID
                     NWLVSTKGRDKNGQLLEILKTMQPYMAMLFVNTKERADDLHAFLTANGLKVAKIHGGI
                     PPRERKRIMNQVKKLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTG
                     RNGMAGTAITLYQPSDDSDIKELEKMGIAFTPKVLKNGEFQDTYDRDRRQNREKAYQK
                     LDTEMIGLVKKKKKKVKPGYKKKIQWAVDEKRRKERRAENRAKGRAERKAKKQHF"
     gene            complement(10362..11372)
                     /locus_tag="VHC05_000433"
     CDS             complement(10362..11372)
                     /locus_tag="VHC05_000433"
                     /EC_number="2.7.8.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="HEQ5401772.1"
                     /translation="MFLTLIAAIISFMVSAFTMPYFIKFYQLKKIGGQQMHEDVKQHL
                     AKAGTPTMGGTVFLLVATAVSLLVSLFSIKNTQSLALISGILSIVVIYGIIGFLDDFL
                     KIFKQINEGLTAKQKLALQLAGGLMFYFLHVSPSGISSINVFGYQLSLGIFYLFFVLF
                     WVVGFSNAVNLTDGIDGLASISVVISLVTYGVIAYVQGQFDVLLLIGTMIGALLGFFC
                     FNHKPAKVFMGDVGSLALGAMLAAISIALRQEWTLLIIGIVYVLETSSVMLQVSYFKY
                     TKKKYGEGRRIFRMTPFHHHLELGGLSGKGKKWSEWQVDAFLWGVGSLASLLVLAILY
                     VF"
     gene            complement(11374..13629)
                     /locus_tag="VHC05_000434"
     CDS             complement(11374..13629)
                     /locus_tag="VHC05_000434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEQ5401773.1"
                     /translation="MKKWQKYVLDYVVRDRRTPVENRVRVGQNMMLLTIFIFFIFIIN
                     FMIIIGTDQKFGVSLSEGAKKVYQETVTIQAKRGTIYDRNGTAIAVDSTTYSIYAILD
                     KSFVSASDEKLYVQPSQYETVADILKKHLGMKKTDVIKQLKRKGLFQVSFGPSGSGIS
                     YSTMSTIQKAMEDAKIKGIAFTTSPGRMYPNGTFASEFIGLASLTEDKKTGVKSLVGK
                     TGLEASFDKILSGQDGVITYQKDRNGTTLLGTGKTVKKAIDGKDIYTTLSEPIQTFLE
                     TQMDVFQAKSNGQLASATLVNAKTGEILATTQRPTYNADTLKGLENTNYKWYSALHQG
                     NFEPGSTMKVMTLAAAIDDKVFNPNETFSNANGLTIADATIQDWSINEGISTGQYMNY
                     AQGFAFSSNVGMTKLEQKMGNAKWMNYLTKFRFGFPTRFGLKDEDAGIFPSDNIVTQA
                     MSAFGQGISVTQIQMLRAFTAISNNGEMLEPQFISQIYDPNTASFRTANKEIVGKPVS
                     KKAASETRQYMIGVGTDPEFGTLYSKTFGPIIKVGDLPVAVKSGTAQIGSEDGSGYQD
                     GGLTNYVYSVVAMVPADKPDFLMYVTMTKPQHFGPLFWQDVVNPVLEEAYLMQDTLTK
                     PVVSDANRQTTYKLPNFVGKNPGETSSELRRNLVQPVVLGTGSKIKKVSHQPGQTLTE
                     NQQVLILSDRFVEVPDMYGWTKSNVKTFAKWTGIDISFKGTDSGRVMKQSVDVGKSLK
                     KIKKMTITLGD"
     gene            complement(13633..13956)
                     /gene="ftsL"
                     /locus_tag="VHC05_000435"
     CDS             complement(13633..13956)
                     /gene="ftsL"
                     /locus_tag="VHC05_000435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsL"
                     /protein_id="HEQ5401774.1"
                     /translation="MTNEKRTQAVTNALQKRIKTFSRIEKAFYTAIIVTAITMAVSII
                     YLQSRKLQLQQEITSLNSHISDQKLELNNAKQEVNELSRRDRIIDIAGKAGLSNRNNN
                     IKKVE"
     gene            complement(13961..14974)
                     /gene="rsmH"
                     /locus_tag="VHC05_000436"
     CDS             complement(13961..14974)
                     /gene="rsmH"
                     /locus_tag="VHC05_000436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="HEQ5401775.1"
                     /translation="MKPFSLTFSFVNLLKYGTIKVMTKEFHHVTVLLHETVDMLDIKP
                     NGIYVDATLGGSGHSAYLLSKLSEQGHLYCFDQDQKAIDNAQVTLKSYIDKGQVTFIK
                     DNFRHLKARLTALGVDEIDGILYDLGVSSPQLDERERGFSYKQDAPLDMRMDRQSLLT
                     AYEVVNTYPFNDLVKIFFKYGEDKFSKQIARKIEQARAIKPIETTTELAELIKAAKPA
                     KELKKKGHPAKQIFQAIRIEVNDELGAADESIQDAMELLALDGRISVITFHSLEDRLT
                     KQLFKEASTVDVPKGLPLIPEDMKPTFELVSRKPILPSHSELTANKRAHSAKLRVAKK
                     IRK"
     gene            complement(15265..15438)
                     /locus_tag="VHC05_000437"
     CDS             complement(15265..15438)
                     /locus_tag="VHC05_000437"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401776.1"
                     /translation="MTNEREKEEAKVALEELLHQIQVIHLELKIVRNWGYFVFFFFGD
                     GMLVSWIKRRNNE"
     gene            complement(15458..16708)
                     /locus_tag="VHC05_000438"
     CDS             complement(15458..16708)
                     /locus_tag="VHC05_000438"
                     /EC_number="1.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003052228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate-5-semialdehyde dehydrogenase"
                     /protein_id="HEQ5401777.1"
                     /translation="MTDMRRLGQRAKQASLLIAPLSTQIKNRFLSTLAKVLVDDTQTL
                     LAANQKDLANAKEHGISDIMMDRLRLTSERIKAIAQGVQQVADLADPIGQVIKGYTNL
                     DGLKILQKRVPLGVIAMIFESRPNVSVDAFSLAFKTNNAIILRGGKDALYSNKALVKL
                     IRQSLEESGITPDAVQLVEDPSHAVAEELMQATDYVDVLIPRGGARLIQTVKEKAKVP
                     VIETGVGNVHIYVDAQADLDMATKIVINAKTKRPSVCNAAEGLVIHEAVAARFIPMLE
                     KAINQVQPVEWRADDKALPLFEQAVPAKAEDFETEFLDYIMSVKVVSSLEEAISWINQ
                     HTSHHSEAIITRDIKAAETFQDLVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKMHA
                     RGPMGLEALTSTKFYINGDGHIRE"
     gene            complement(16701..17522)
                     /gene="proB"
                     /locus_tag="VHC05_000439"
     CDS             complement(16701..17522)
                     /gene="proB"
                     /locus_tag="VHC05_000439"
                     /EC_number="2.7.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 5-kinase"
                     /protein_id="HEQ5401778.1"
                     /translation="MMKRQFEDVTRIVIKIGTSSLVLPTGKINLEKIDQLAFVISSLM
                     NKGKEVILVSSGAMGFGLDILKMEKRPTNLAKQQAVSSVGQVAMMSLYSQIFAHYQTN
                     VSQILLTRDVVVFPESLANVTNAFESLISLGIVPIVNENDAVSVDEMDHATKFGDNDR
                     LSAVVAGITKADLLIMLSDIDGLFDKNPTIYEDAQLRSHVAVITQEIIASAGGAGSKF
                     GTGGMLSKIQSAQMVFENKGQMVLMNGANPRDILRVLEGQPLGTWFKQIEEVRHD"
     gene            complement(17586..19214)
                     /locus_tag="VHC05_000440"
     CDS             complement(17586..19214)
                     /locus_tag="VHC05_000440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5401779.1"
                     /translation="MNWSTIWELIKINILYSNPQSLANLKKRQEKHPKENFKAYKSMM
                     RQQALMIAMFLVIYLFMFIGVDFSHYPGLFSFDVAMFFIMSTLTAFSSLYTIFYESND
                     LKLYIHLPVTSEELYIAKIVSSLGMGAVFLMPLISLLLIAYWQLLGNPLSILVAIVLF
                     LVLLVSSMVLAIYINAWVGKIIVRSRKRKLISTIMMFVSTFGAFVLIFAINISNNKRT
                     MTDGVFTDYPTIPYFKGFYDVIQAPFSTAALLNFWLPLLLVLAMVYGIVTKVMPNYYR
                     EAFYISNENKAKQTKKPVNRPHQNQSLAQLLRKHHLLTLQNATLLTQTYLMPLMYVML
                     FIGPSLSRGTGFFKHISPDYFGVALLFGVSLGIMCATPTSFIGVGISLEKDNFTFIKS
                     LPITLKKFLLDKFCLLVGLQLIVPMVIYLVFGLFVLHLHPLLTIAFCLGYALSLIVQG
                     EFMYRRDYRLLDLKWQDMTQLFTRGNGQWLTMGLIFGNLIVTGVVGFGAVIIANIIQQ
                     PLLISVLLSCLTLMVLGIAHLWIQKTFWQSLEKL"
     gene            complement(19219..19953)
                     /locus_tag="VHC05_000441"
     CDS             complement(19219..19953)
                     /locus_tag="VHC05_000441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401780.1"
                     /translation="MIEFKHVSKLYGDKEALSDLNVTINDGEIFGLIGHNGAGKTTTI
                     SILTSIIEASYGEVFVDGQLLTENREAIKKQIAYVPDSPDIFLNLTPNEYWQFLAKIY
                     GVSDEDREERLAQLTTLFELKEEVNQTIDSFSHGMRQKVIVIGALVSNPNIWILDEPL
                     TGLDPQASFDLKGMMKAHAASGHTVLFSTHVLSVAEQLCDRIGILKKGKLIFVGTIDE
                     LKEHHPDKDLESIYLELAGRKAQEEG"
     gene            complement(19987..20253)
                     /locus_tag="VHC05_000442"
     CDS             complement(19987..20253)
                     /locus_tag="VHC05_000442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009881243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HEQ5401781.1"
                     /translation="MEKKRQRLYDVIRHAYDYPENRENVALSQLLLAASNRLIKHSNP
                     LLVAYQLNQDVDNYLLDNDILLPKSLCRFKQSLEKYILEEASSV"
     gene            complement(20445..22430)
                     /gene="tkt"
                     /locus_tag="VHC05_000443"
     CDS             complement(20445..22430)
                     /gene="tkt"
                     /locus_tag="VHC05_000443"
                     /EC_number="2.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013793690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HEQ5401782.1"
                     /translation="MTFDAIDQLAVNTVRTLSMDAIQAANSGHPGLPMGAAPMAYVLW
                     NHFMNINPKTSRNWSNRDRFILSAGHGSAMLYSLLHLAGYDLTVEDLKNFRQWGSKTP
                     GHPEVNHTDGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKPGFDIVDHYTFALNGDG
                     DLMEGVSQEAASMAGHLKLGKLVLLYDSNDISLDGPTSMAFTEDVKGRFEAYGWQHIL
                     VKDGNDLEEIAAAIEAAKAETEKPTIIEVKTIIGFGAEKQGTSAVHGAPLGAEGIAFA
                     KKAYQWTHQDFEVPAEVTERFAQGLQARGEKAEQAWNDLFAAYEAEYPELAAEYQKAF
                     TNEAAQVELEAHELGSSMASRVSSQQAIQQISEQVASFWGGSADLSASNNTMVKAETD
                     FQSGHYEGRNIWFGVREFAMAAAMNGIALHGGTRVYGGTFFVFSNYLLPAVRMAALQN
                     LPTVYVMTHDSIAVGEDGPTHEPIEQLASVRSMPNLNVIRPADGNETNTAWKRAIAET
                     DRPTMLVLTRQNLPVLEGTKELAEDGLNKGAYILSEAKGDLDGIIIATGSEVKLAMDT
                     QEALEAEGIHVRVVSMPSQNIFDEQSAEYKESILPAAVTKRLAIEAGSSFGWAKYVGL
                     AGKTLTIDTWGASAPGNRIFEEYGFTVANATELYKSL"
     gene            complement(22648..23292)
                     /gene="fsa"
                     /locus_tag="VHC05_000444"
     CDS             complement(22648..23292)
                     /gene="fsa"
                     /locus_tag="VHC05_000444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012657835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HEQ5401783.1"
                     /translation="MKFFLDTANVAAIKAINELGVVDGVTTNPTIISREGRDFETVIK
                     EICDIVDGPISAEVTGLTADAMVEEARSIAKWHDNVVVKIPMTTEGLKATNILSKEGI
                     KTNVTLIFTVSQGLMAMKAGATYISPFIGRLEDIGTDAYQLISDLREIIDLYDFQAEI
                     IAASIRTTAHVEAVAKLGAHIATIPDPLFAKMTQHPLTTNGLKTFMEDWASFKK"
     gene            complement(23414..24913)
                     /locus_tag="VHC05_000445"
     CDS             complement(23414..24913)
                     /locus_tag="VHC05_000445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEQ5401784.1"
                     /translation="MKIEDLMDKERRAQYRLLVTLYHAKETLRLKDLMRLSNLSKVTL
                     LKYIDNLNHLCREQGLACQLLLEKDSLSLKENGQFHWEDLVALLLKESVAYQILTYMY
                     CHEHFNITNLSVELMVSEATLNRQLAHLNQLLSEFDLALSQGRQLGSELQWRYFYFEL
                     FRHTLTRQGIDALVNQLDASHLATLIERLIGQSLSAEALEQLLIWLAISQARMSFQKG
                     YNDHFLRDSDFMTSNIFFKRLESMLLHYLRRYALEFDAFEAKSLFVFLHAYTLLPIAS
                     MKYSLGFGGPIADHISEALWLLKKAHVIIHQTKEEIIYGLGIFFSKAYFFKGAILSQP
                     TNSQYLYQLVGEDKRALLRVIINHLVLQMGQETDFGQQLSDDILALLVFSIERHHEPL
                     LVGLALGQNKVEAAIAELAIRRHLGHRRDFQLMPYDHQKVYDCLITYQTVYLPRQDLP
                     YYRLKQYSSPYELAALEDFLKSLFQQKNKQEEEPLVSPKAKSSFEHNSV"
     gene            complement(24903..26249)
                     /locus_tag="VHC05_000446"
     CDS             complement(24903..26249)
                     /locus_tag="VHC05_000446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HEQ5401785.1"
                     /translation="MTLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNY
                     IPNGINQLFRGDIQDLSDAMWGRACLAAQIESNHRFIQAEVLAIEAPSNTLFLKDSQG
                     RVFEEGYETLVCAMGASPQSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGA
                     GLIGLDLAYSLSLQGKRVKLIEAAERPDFYQTDAELIAPVMAEMSIHHVTFINNKHVT
                     AIHEIEGKVVAHTEQGDTFQGDLAILAINFRPNTHLLQGQVACALDKTILVNENLQTS
                     QANIYAIGDMVSLHFGILGMDYYTPLINQAMKTGQALALHLAGYPIPPLQTVKVLGSS
                     HFGYYRASVGVTEEEAELYMDTCSYLYQNGDSKNLFWLKLIARKTDGILIGAQLLSKT
                     NALVIANQLGQALALKVTDADLAFQDFLFLQGHSDLAYHLHEACLKLFEKRLRHED"
     gene            complement(26358..27059)
                     /locus_tag="VHC05_000447"
     CDS             complement(26358..27059)
                     /locus_tag="VHC05_000447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin family protein"
                     /protein_id="HEQ5401786.1"
                     /translation="MDIFGEFLGTALLVLLGNGVVSGVVLPKTKTHASGWIVIATGWG
                     IAVAVAVFISGKVAPAHLNPAVSLAFAMSGTIAWSTAIAYSLAQLLGAMLGSTLVFLQ
                     FRPHYLAAESQADILGTFATGPAIRDTSSNLLSEIFGTFVLMLGILAFGLYDMPAGLG
                     TLCVGTLVIGIGLSLGGTTGYAINPARDLGPRLVHAILPLNNKGDSDWSYAWIPVVGP
                     IIGAALAVLLFQVMS"
     gene            complement(27061..28899)
                     /gene="glpO"
                     /locus_tag="VHC05_000448"
     CDS             complement(27061..28899)
                     /gene="glpO"
                     /locus_tag="VHC05_000448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glycerol-3-phosphate oxidase"
                     /protein_id="HEQ5401787.1"
                     /translation="MEFSRETRRLALQKMQERDLDLLIIGGGITGAGVALQAAASGLD
                     TGLIEMQDFAQGTSSRSTKLVHGGLRYLKQFDVEVVSDTVSERAVVQQIAPHIPKPDP
                     MLLPVYDEPGSTFSMFRLKVAMDLYDLLAGVSNTPAANKVLTKEEVLKREPDLKQEGL
                     LGGGVYLDFRNNDARLVIENIKRANRDGALIASHVKAEDFLLDDNGKIIGVKARDLLS
                     DQEIIIKAKLVINTTGPWSDEIRQFSHKGRPIHQMRPTKGVHLVVDRQKLPVSQPVYV
                     DTGLNDGRMVFVLPREEKTYFGTTDTDYTGDLEHPQVTQEDVDYLLGVVNNRFPNANV
                     TIDDIESSWAGLRPLLSGNSASDYNGGNSGKVSDDSFDHLVDTVKAYINHEDSREAVE
                     KAIKQVETSTSEKELDPSAVSRGSSFDRDENGLFTLAGGKITDYRKMAEGALTGIIQI
                     LKEEFGKSFKLINSKTYPVSGGEINPANVDSEIEAYAQLGTLSGLSMDDARYLANLYG
                     SNAPKVFALTRQLTAAEGLSLAETLSLHYAMDYEMALKPTDYFLRRTNHLLFMRDSLD
                     ALIDPVINEMAKHFEWSDQERVAQEDDLRRVIADNDLSALKGHQEG"
     gene            complement(28915..30441)
                     /gene="glpK"
                     /locus_tag="VHC05_000449"
     CDS             complement(28915..30441)
                     /gene="glpK"
                     /locus_tag="VHC05_000449"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HEQ5401788.1"
                     /translation="MSQEKYIMAIDQGTTSSRAIIFNQKGEKVSSSQKEFPQIFPHAG
                     WVEHNANQIWNSVQSVIAGAFIESSIKPSQIEAIGITNQRETTVVWDKKTGVPIYNAI
                     VWQSRQTAPIAEQLKEDGHTKMIHEKTGLVIDAYFSATKIRWILDHVPGAQERAEKGE
                     LLFGTIDTWLVWKLTDGAVHVTDYSNAARTMLYNIKDLTWDDEILELLNIPKDMLPEV
                     KSNSEIYGKTAAFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNT
                     GDEMQLSSNNLLTTIGYGIGGKVHYALEGSIFIAGSAIQWLRDGLKMIETSPESEQFA
                     LASTSDDEVYVVPAFTGLGAPYWDSNARGSVFGLTRGTSKEDFVKATLQSIAYQVRDV
                     IDTMQVDSGIDIQQLRVDGGAAMNNMLMQFQADILGIDIARAKNLETTALGAAFLAGL
                     AVGYWEDMDALKELNATGQLFKASMNESRKEKLYKGWKRAVKATQVFTQEEDADDDAK
                     "
     gene            complement(30801..31193)
                     /locus_tag="VHC05_000450"
     CDS             complement(30801..31193)
                     /locus_tag="VHC05_000450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054910.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PepSY domain-containing protein"
                     /protein_id="HEQ5401789.1"
                     /translation="MCLSYNRRNQRKKVVLMTIKKFSLLAIASLSLLSLAACDMDDKD
                     DHMDNQPKTSQTSKKVKLSEDKAKSIALKDASVTEADAQMLSVTQDNEDGKAVYEIEF
                     QNKDQEYSYTIDANSGDIVEKSSEPIND"
     gene            complement(31320..31577)
                     /locus_tag="VHC05_000451"
     CDS             complement(31320..31577)
                     /locus_tag="VHC05_000451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF896 family protein"
                     /protein_id="HEQ5401790.1"
                     /translation="MDPKKIARINELAKKKKTVGLTGPEKVEQAKLREEYIEGYRRSV
                     RHHIEGIKLVDEEGNDVTPEKLRQVQREKGLHGRSLDDPKS"
     gene            complement(31731..33770)
                     /locus_tag="VHC05_000452"
     CDS             complement(31731..33770)
                     /locus_tag="VHC05_000452"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit beta"
                     /protein_id="HEQ5401791.1"
                     /translation="MSKNLLIELGLEELPAYVVTPSEKQLGERLATFLTENRLSFEDI
                     QTFSTPRRLAVRVSGLADQQTDLTEDFKGPAKKIALDADGNFSKAAQGFVRGKGLTTD
                     AIEFREVKGEEYVYVTKHEAGKPAKEVLLGVTEVLSAMTFPVSMHWANNSFEYIRPVH
                     TLTVLLNDEALELDFLDIHSGRVSRGHRFLGTETTITSADSYEADLRSQFVIADAKER
                     QEMIVEQIKAIEAAQGVQVDIDADLLNEVLNLVEFPTAFMGSFDAKYLDVPEEVLVTS
                     MKNHQRYFVVRDQEGHLMPNFVSVRNGNDQAIENVIKGNEKVLVARLEDGEFFWREDQ
                     KLQIADLVAKLTNVTFHEKIGSLAEHMDRTRVIAASLAKEANLSAEEVTAVDRAAQIY
                     KFDLLTGMVGEFDELQGIMGEKYARLAGEDAAVATAIREHYLPDAAGGALPETKVGAV
                     LALADKLDTLLSFFSVGLIPSGSNDPYALRRATQGIVRILDHFGWRIPMDKLVDSLYD
                     LSFDSLTYANKADVMNFIRARVDKMMGKAVPKDIREAVLESSTFVVPEMLAAAEALVK
                     ASHTENYKPAVESLSRAFNLAEKADASVQVDPSLFENEQENTLFAAIQGLTLAGSAAQ
                     QLEQVFALSPVINDFFDNTMVMAEDQALKNNRLAILSDLVSKAKAIAAFNQLNTK"
     gene            complement(34148..35065)
                     /gene="glyQ"
                     /locus_tag="VHC05_000453"
     CDS             complement(34148..35065)
                     /gene="glyQ"
                     /locus_tag="VHC05_000453"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018163989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit alpha"
                     /protein_id="HEQ5401792.1"
                     /translation="MSKKLTFQEIILTLQQYWNDQGCMLMQAYDNEKGAGTMSPYTFL
                     RAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLASLEK
                     LGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATSPVTAE
                     VTYGLERLASYIQEVDSVYDIEWAPGVKYGEIFLQPEYEHSKYSFEMSDQDMLLENFE
                     KFEKEASRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARVVA
                     KTFVAERKKLGFPLLDEATRAILLAEDDE"
     gene            complement(35437..35970)
                     /locus_tag="VHC05_000454"
     CDS             complement(35437..35970)
                     /locus_tag="VHC05_000454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenylcysteine carboxyl methyltransferase
                     family protein"
                     /protein_id="HEQ5401793.1"
                     /translation="MTIFLVMLAMFTIRLVFLKKSITNEKAILAQGGQEFGAQNTKFL
                     TLLHIMIYVFAVIEALLKQIKFDGISFLGLLLMLLSVAVLYEVTRILGDIWTVKLMLA
                     KNHKYVDHWLFKTIKHPNYFLNIAPELVGIALLCHAKITAMLLFPCYIVVIYLRIREE
                     NKLLAEVIIPNGTRTKP"
     gene            complement(36102..36941)
                     /locus_tag="VHC05_000455"
     CDS             complement(36102..36941)
                     /locus_tag="VHC05_000455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HEQ5401794.1"
                     /translation="MVTTVKMTSGYEIPVLGFGTYQAADGEEAYQSTLAAIKAGYRHI
                     DTAAIYKNEESVGRAIKDSGVLREDLFITTKLWNDAHSYEGAKDALAASIDRLGLDYV
                     DLYLIHWPNPKALRNTWKEANAQAWQYMEEAVEAGLIKSIGVSNFMVHHLEALQETAK
                     ITPAINQIRLAPGCYQKEVVDYCKANEILLEAWSPLGQGEIFDNETMQQLANKYDKTV
                     AQVALAWSLAEGFIPLPKSVHDERIKENMAIFDVSLTQEDKKTIRYLSGMSAIPNPDT
                     TSF"
     gene            complement(37063..38211)
                     /gene="nagA"
                     /locus_tag="VHC05_000456"
     CDS             complement(37063..38211)
                     /gene="nagA"
                     /locus_tag="VHC05_000456"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HEQ5401795.1"
                     /translation="MTCYLKADCFYYPTEVKPAGYLSLHDGVFGEWTEIVPADAQIID
                     YTGYQIAPGLVDTHIHGYAGADVMDNSAQGIHQMSEGLLATGVTSFLPTTLTSTFEQL
                     EKVSGTIASVADQVKGAKIQGIYFEGPYFTEEYKGAQNPSYMKNPRLEEFDAWQKAAK
                     GLIKKIALAPERDGVAEFVSTVTKQGVTVALGHSNGTYQEAKEAVQAGASVWVHAYNG
                     MRGLTHREPGMVGAVYNLPNTYAELICDGHHVSPVACDILMQQKGHDHVAMITDCMRA
                     GGSPDGDYLLGEFSVVVANGTARLKESGNLAGSILKLKDGLRNVVAWGIATPAEAIHM
                     ATYVPAVSVGIDDVCGQIKAGHAADFIVLDKDLTLVATYLNGQKAFDA"
     gene            complement(38329..39960)
                     /locus_tag="VHC05_000457"
     CDS             complement(38329..39960)
                     /locus_tag="VHC05_000457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HEQ5401796.1"
                     /translation="MSVNWQDIAFHFFGGLGLFLFSIKYMGDGLQQAAGDKLRYYIDK
                     YTSNPFFGILVGIAMSALIQSSSGVTVITVGLVSAGLLNLRQAIGIVMGANIGTTITS
                     FLIGFKLGDYALPMIFIGAACLFFTSNKKLNNFGRIIFGVGGIFFSLNLMGDAMDPLK
                     SVSAFQNYLATLGDKPFQGVFIGTALTMLIQSSAAIIGILQGLFSGGLLTLQGAIPIL
                     LGSNIGTCITAVLAAIGSNIAAKRVAAAHVLFNLIGTIIFMIILVPFTSLMLWLQSKL
                     SLTPEMTIAFSHGSFNITNTILLIPFISLLAMIVTRLIPGEDEVVKYEALYLDRLLIT
                     QAPSIALGNAHKELVHLASYAIQAFEASYSYIMTADDKFGEKVKRYERAVDTIDEELT
                     TYLVDISNEALSPSENEVLAGILDSSRDLERIGDHSESLGILIEGIISKQIGFSISAR
                     QELTEMYQLTHCLTLDAIRAIVDSDTDLAQTIVTRHKEIEEKERRLRKTHIKRLNCGE
                     CTAQAGINFIDIISHYTRITDHALNLAEKVLSHQL"
     gene            40162..40884
                     /locus_tag="VHC05_000458"
     CDS             40162..40884
                     /locus_tag="VHC05_000458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401797.1"
                     /translation="MATMKQYHKGDSMTKSQKEALYWMLSVLTITLIGGSCLIFGSHP
                     QTQDKVAKHSKSAASLLKKAVKAVNDADRLATAAAIQEAQKAVDKLAESSKKKTLQEQ
                     LNVAKAKQEQEDAATQAVKAAEETLNQNLKDIAQKAVNDLSNKGKKAALQSRLDAILP
                     AKPIIDEFPRQSGEITDNSYWTPFPGDVSDTYDNSQSPTLDPSSESSASDVTPQPSHP
                     DPIPPQTSSEPSDSGDKQSSKE"
     gene            complement(41013..41855)
                     /locus_tag="VHC05_000459"
     CDS             complement(41013..41855)
                     /locus_tag="VHC05_000459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEQ5401798.1"
                     /translation="MTWKIVTDSGCDLRSLTRQSKELRFERVPLTLQIGTEIFRDDDG
                     LDIDNMMTTMYQSSKATTSSCPSPEAFLQAYRGADNVIVMTLTGTLSGSHNSARLAKN
                     ELLEENPNVNIHLIDSLSAGGEMDLLVLELERLINLGLSFEEVVKQITAYQQKTRLIF
                     VLAKVDNLVKNGRLSKLVGKVIGLLNIRMVGKASNKGTLELLQKARGQKKAVSALIEE
                     IQKEGYAGGKVYIAHAQNPKICEQISEKIKSLYPDAVIQTGRTSGLCSFYAEDGGLLM
                     GYEI"
     gene            42148..42705
                     /locus_tag="VHC05_000460"
     CDS             42148..42705
                     /locus_tag="VHC05_000460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEQ5401799.1"
                     /translation="MTDKALSKRSLQNLTQFNKETRRIARESMEIALLNLLETKPLGD
                     ITISELVTKAGVSRNAFYRNYTSKEAIIEQLLVGVIRRIFRGLKQFDIKTQAYQAWLY
                     LFTEAKKEAQLLKMIFKHHLHHLLTRLVTKRLKAYQKLKDKKQSHYKRLFWSNAIVSV
                     LTNWISDDMIVPAEEMAAMGLPLLT"
     gene            complement(42741..43565)
                     /locus_tag="VHC05_000461"
     CDS             complement(42741..43565)
                     /locus_tag="VHC05_000461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEQ5401800.1"
                     /translation="MIQLIAIDLDGTLLNQDKQIPKENITAIQEAAQSGLKIVLCTGR
                     PQSGTRPYFDQLGLTQEEFLIINNGCSTYSSPDWQLRHSKMLKVSDIELLEELSQSFP
                     DIYLTLTEENDYLVLEEEVPDLVQEDGDLVFTIVKPVSLAELSDTPRLIFQAMYLGEK
                     AALDAFERAVRNQLSQSFHVVRSQDNILEILPQGVSKASALKELVEDLGLTADQVMAI
                     GDAPNDIEMLTYAGLGVAMENASAAIKPLADKVTLTNDMAGVAQAIRQFALAAQKD"
     gene            complement(43567..44184)
                     /locus_tag="VHC05_000462"
     CDS             complement(43567..44184)
                     /locus_tag="VHC05_000462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trimeric intracellular cation channel family
                     protein"
                     /protein_id="HEQ5401801.1"
                     /translation="MTIDMWEILNIIGTIAFALSGAIVAMEEEFDILGIFILGFVTAF
                     GGGAIRNTLIGLPIEALWGQKPEFTCAFFAMVLIMLFPKLMARGWVRAAVLTDAIGLA
                     AFSVQGALHAVRLNQPLSAVIVAAVLTGAGGGVVRDILAGRKPSVLRSEIYAGWSILA
                     AIVLHFKLADSTIECYALVVLLTTLRMIGNRKKWNLPKIKWKEER"
     gene            complement(44381..45358)
                     /gene="lacD"
                     /locus_tag="VHC05_000463"
     CDS             complement(44381..45358)
                     /gene="lacD"
                     /locus_tag="VHC05_000463"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="HEQ5401802.1"
                     /translation="MTITANKRHYLEKVSHQGIISALAFDQRGALKQMMAAHQEGEAT
                     VTQIETLKVLVSEELTPYASSILLDPEYGLLATKVKANQTGLLLAYEKTGYDATTTSR
                     LPDCLVEWSVKRLKAAGADAIKFLLYYDVDGDEQINLQKQAYIERIGSECTAEDIPFF
                     LELLSYDERISDNNSAAYAKLKPHKVNGAMLVFSDKRFGVDVLKVEVPVNMAYVEGFT
                     EEEVHYSQAEAIKAFQDQEAASHLPYIYLSAGVSAKLFQETLYFAAAAGAQFSGVLCG
                     RATWAGSVPVYITKGEDEARKWLCTEGFQNIDELNRVLEETASPWTEKI"
     gene            complement(45405..45858)
                     /locus_tag="VHC05_000464"
                     /pseudo
     CDS             complement(45405..45858)
                     /locus_tag="VHC05_000464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061423.1"
                     /note="catalyzes the formation of tagatose
                     1,6-bisphosphate from tagatose 6-phosphate and ATP;
                     frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-6-phosphate kinase"
     gene            complement(45868..46383)
                     /gene="lacB"
                     /locus_tag="VHC05_000465"
     CDS             complement(45868..46383)
                     /gene="lacB"
                     /locus_tag="VHC05_000465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="HEQ5401803.1"
                     /translation="MKIAIGCDHIVTNEKMAVSDFLKSKGYDVIDCGTYDHTRTHYPI
                     FGKKVGEAVVSGQADLGVCICGTGVGINNAVNKVPGIRSALVRDMTTALYAKEELNAN
                     VIGFGGKITGELLMCDIIDAFIKAEYKETEENKKLIAKIAHLETHHANQEDPDFFTEF
                     LEKWDRGEYHD"
     gene            complement(46398..46823)
                     /gene="lacA"
                     /locus_tag="VHC05_000466"
     CDS             complement(46398..46823)
                     /gene="lacA"
                     /locus_tag="VHC05_000466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="HEQ5401804.1"
                     /translation="MAIILGADAHGNALKELIKSFLQEESYDIIDVTDINSDFIDNTL
                     AVAKAVNEAEGRLGIMVDAYGAGPFMVATKLKGMVAAEVSDERSAYMTRGHNNARMIT
                     IGAEIVGPELAKNIVKGFVTGPYDGGRHQIRVDMLNKMA"
     gene            complement(47080..48531)
                     /locus_tag="VHC05_000467"
     CDS             complement(47080..48531)
                     /locus_tag="VHC05_000467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HEQ5401805.1"
                     /translation="MMQPFLDIINKILGFPIQLGSGVVMLIVMTGLAMIFGVKFTKAL
                     EGGIKLAIALTGIGAIIGILTGAFSESLQAFVKNTGISLNIIDVGWAPLATITWGSPY
                     TLYFLLVMLVVNIVMIVMKKTDTLDVDIFDIWHLSITGLLIMWYAARNHLPVFVSLLI
                     ATVAVILVGVLKIINSDLMKPTFDDLLGTGSQSPMTSTHMNYMMNPIIMVLDKIFDKV
                     FPGLDKYDFDAAKLNKKIGFWGSKFFIGMALGFVIGIMGDPHFTVESIKNWFGLGFTA
                     GACLELFSLIGSWFIAAVEPLSQGITNFANARMHGRRFNIGLDWPFIAGRAEIWACAN
                     ILAPIMLIEAVLLSKVGNGILPLAGIIAMGMTPALLVVTRGRLIRMIIFGSLLLPLFL
                     LSGTMIAPFATELAKKVGAFPAGTSAGSLITHSTLEGPMEKIFGYVIGQATTGQIASI
                     ITLIIFVAIYLGLFAWYANQMKARNAEYAKTMK"
     gene            complement(48557..48862)
                     /locus_tag="VHC05_000468"
     CDS             complement(48557..48862)
                     /locus_tag="VHC05_000468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEQ5401806.1"
                     /translation="MIKILAACGAGVNSSHQIKDAIESQMTDRGYDVHCDAVMVKDIT
                     EELVSRYDIFTPIAKTDLGFEMPIPTVEAGPILYRIPIMSEPVFAELERVIKENHLQ"
     gene            complement(48855..49328)
                     /locus_tag="VHC05_000469"
     CDS             complement(48855..49328)
                     /locus_tag="VHC05_000469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009881202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEQ5401807.1"
                     /translation="MFPNILFTEARTQPELFDLVASHLEKVGYVTQEYHQALVEREAV
                     FPTGLKVDFKDGSDILYAAIPHTETKYCLVDQVVYVRNSQALTFKHMINPEEDCLVTD
                     FFFIINSQNEGQTTILSNLITFFITKGNLSYLASLKDDKQAISNYLIEKGVFQHD"
     gene            49565..50335
                     /locus_tag="VHC05_000470"
     CDS             49565..50335
                     /locus_tag="VHC05_000470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEQ5401808.1"
                     /translation="MLKRERLLKITEIVNEQGIVTVNDIIQTLNVSDMTVRRDLDELE
                     KAGKLIRIHGGAQSITMPNKKERSNIEKQTVQTKEKWELASYATQLVNDGETIFIGPG
                     TTLECFAEQLKNRQIRIVTNSLPVFNILQDSETIDLILIGGEYRSITGAFVGSLASQN
                     ISSLKFAKAFISCNGIYKNDIATYSETEGEIQKLAFNNSIEKYLLVDNQKFNAYDFFI
                     FYHLNNIDAVVTDSQITEDVIERYSQFTQLLVAHENKE"
     gene            complement(50539..50742)
                     /locus_tag="VHC05_000471"
     CDS             complement(50539..50742)
                     /locus_tag="VHC05_000471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy-metal-associated domain-containing
                     protein"
                     /protein_id="HEQ5401809.1"
                     /translation="MEKHYQVTGMTCDGCARTVTEKLSAVPGVQSVQVNLEKGEAKVT
                     GRPLTFLLKRALKDTKFELHKWS"
     gene            complement(50756..52987)
                     /locus_tag="VHC05_000472"
     CDS             complement(50756..52987)
                     /locus_tag="VHC05_000472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper-translocating P-type ATPase"
                     /protein_id="HEQ5401810.1"
                     /translation="MAKEIFLVEGMSCASCALTIEKTVNQLPEVEQAVVNLATEKLTV
                     TYQDDDLETAKVIQAVKAAGYGAQVFDEHAKHMQTGRRDEDLKVIWSQVLWSALFTIP
                     ILYLAMGHMVGLWLPSFLQPDRYPFVYSFSQLLLTIPVLVLNRHYYHNGFKALFKGYP
                     NMDSLVALATSFAFAYSLYGVVEISMGQAHFVHSLYFESVVVILTLIGLGKYFESRSK
                     GRTSQAIQKLLSLKATVVRVWRNSQWQLLPLEEVSYDDLVLVQPGEKVSIDGIIVEGH
                     SSLDESFLTGESFPVEKGEKDNVFAGSLNGKGALTIKPDKLGNDTLLAQIIQLVENAQ
                     ENKAPIAAIADRVSGVFVPVVLVLTLLTGVFWLVFMQESLRFSLTTAIAVLVIACPCA
                     LGLATPTAIMVGTGRAAENGILFKGGDILEQAHQVDTVVFDKTGTITEGKPSLQKLLT
                     FSGDEHLILQEAASLEAYSQHPLGEAIVRAAQEAGYDSLPVEEFESLTGLGVTGQLEG
                     RRLAIGNATLMATLGIDLASVQSVCAKASGKGQTIVYYAKEGQLRALFSIADAVKEDS
                     QATVEALHQLGIHTIMLTGDHDATAKAIASQVGITDVISQVLPDQKAGVITNLQSQGR
                     KVAMVGDGINDAPALAVADIGIAMGSGTDIAIESADVILMKPDMLDLVKALSLSRATM
                     RIVKENLFWAFIYNVLMIPVAMGLLHLFGGPLLNPMLAGFAMSFSSVSVVLNALRLKG
                     KTI"
     gene            complement(52987..53424)
                     /locus_tag="VHC05_000473"
     CDS             complement(52987..53424)
                     /locus_tag="VHC05_000473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopY/TcrY family copper transport repressor"
                     /protein_id="HEQ5401811.1"
                     /translation="MNQNISDAEWEVMRVVWASGDIKSSDIITILRKKYQWSDSTIKT
                     LIGRLVKKNLLTSYRQGRAYIYQALLDETLLQKEALATVLDGICQRQHTRLLLERLYD
                     LPMTLEEIEAFQELLEVKKENAVLEVPCNCLPGQCHCQKKETY"
BASE COUNT        16140 a        11690 c         9634 g        16069 t
ORIGIN      
        1 tctttaatcg tattaaagaa aaggtacaac gttaagggaa ttagcaactg atttttcaaa
       61 cgttaaccta aaacaaaata gacttattta aaattgttat aaatagcaac taatgccata
      121 agagagtata catgaaaaaa acacgtttcc atataccgaa gacgtgtttt ttcatatgtc
      181 attttcttag cataataatt tttttcatgt tcactttctt atgcggagtc caatccgttt
      241 gctgttcgtt ttgtccagct tttagatttc atacagtcgc aaagaaagga attagtattg
      301 tgctaaagca cccattggat cccaaggagc tagtacttgt ggctcttttt cataagccgc
      361 taactcgtca gctgttaaga attctttacg gacaacaatt tgataggtat attcatccat
      421 ccaagcatct gaagcaacaa agtaaccttt gtcaccaacc ttctcacccc atgaattttc
      481 aatcttccat tttaacggtt ttcctgtttc atctaagtca acacctgtta aaaccatagc
      541 atgtgtcatc aaactttcac tataatccaa acgtccagcc ttatcttgac taagattgat
      601 atccatacta gcttcaaaat cgtaagtatt agttgccaaa atgccttttt gacgatctga
      661 aacttgaccc acatcagagc caaaccaaac ggactcacca gcctgcatct gcttgatagc
      721 tagttctttg aaacgtttca tatcaaggtt gaggtagcga acctcacgac taccgaccac
      781 atttcctagc atctcaacag tgtatgattt gccataaggc ttatcggcag ttggcgcatt
      841 aataacagac acataatcag aaagctttaa gccaacaaat ttgtcgtaaa acgcttgcgg
      901 tgtcaaacct ttctcaacat gatagtggtc atctttatca cggtaggcaa aatcaaaatg
      961 acgaggtggt aaaccaaggg tcatggccaa gaagttaaaa atttcctgaa gaagctctgc
     1021 ttttcgatcc tcaacttggt ctgccttagc acctgacgca atcaggtcac gaagaatttg
     1081 agcatcttgg cgcaataatt tattcaaata ctggtttaat tcacgactgt tacttgatga
     1141 gattgattct gggtaaacag attttggcac cactccatac ttctcaaaca aggaaaccac
     1201 catgtcccac tgaccaccat cttgttgtgg aacatccaag agaaacttaa ctttacgact
     1261 ggttaattct tggtcagctg tagcaatgac ctgctccata aaccagttag ctttttcata
     1321 cttatcccaa aagaaagtat gagcttgtga cagttcaaaa ttttctaact taaattctgt
     1381 gattaatttg tgtcggaaag tgttcaaggc agcaaacatc cagcaacgac cagaagcctt
     1441 ttggttagat accttatctt tagttaaatc aatagaaaac acaaaatcat tgtccacttc
     1501 actttgacgg gtttctaatg attttagcaa accattatgc gtaacggcat tctcaatagc
     1561 tgaaaatttt gcattggctt cgtaatgagc aaataattgt tctgtaaatg tctctgttaa
     1621 tgctgacatt attgtcctcc taaaatatta agataagctt cacctgaaat aatattggca
     1681 agatggttat tatccagcca ttctattcta aaggattact tctattatag accttatttg
     1741 attttcttca agaaaaaagt taggataacc taactttttt tgtttccttt ttttactctt
     1801 tgaacatcag ctcttatttc caaaaatcat caaaaatggt gattggcagg tgacgcttgt
     1861 gttgtccttt atgccaccat ttttcaatag ttgcttgagc tactttggaa atcagcttcc
     1921 cttccaaata gtcgtcgatg tcttgatagg tcacccctag ggcaacctca tcagccaagc
     1981 ctggtttttg atcttctaaa tcagcagttg gaactttttc atacaaagca gcatctgctc
     2041 ctaaaacttt caaaagagcc tttccttgac gtttgttaag cctaaagagg ggaagaatat
     2101 ctgctccacc atcaccaaat ttagtaaaga aaccagtgat gttttctgcc gcatgatccg
     2161 ttccaataac agcaccggcc atttggccag caatggcata ttgactgatc attcgctgac
     2221 gtgctttaat attaccttta ttgaaatcag aaatctcaac gcctgctgct tgtagagcct
     2281 ctacttgacc gtccacagct gccttgatat taatggtaag ggtctgatct ggtgcaataa
     2341 aagccaaggc tttttgcgca tctgcttcat cagcctgaac cccataaggc aagcgaacag
     2401 ctataaattg gtaagcttga tcacttgctt cctcccgtaa ctctgcaatg gccatctggg
     2461 ctagctttcc tgcgagggta gaatcctgac ctcccgaaat gcctaagaca taagttttta
     2521 aaaatgagtg cttacgcaaa taagctttta aaaaatcaac ggtttttcga atttcttctt
     2581 gtggatcaat gctagccttg acgcctaatt gtcgaattat ctcttcttgt aatgtcatgt
     2641 cattcactct ttccatgagt atctttacga atgttatcaa tcaaggtcat cttattttgc
     2701 cacacatctc gtgccaagtc tactgggtag tcttgaggat ttaagacacg cttgtattca
     2761 tcccaaagct tgtcaaattc ttttttagca taagccttga tttcagctaa ggtcggtagc
     2821 tggtaaacta attctccctt gacaaaaata tcaactaaga gaggaattgc atcaaattct
     2881 ttaacggttt tcttaatata ggtataggtc ggatggaaca tctcaatctc agttaattca
     2941 ttaacattaa tatcagtaaa cgtgatatag tcgccttctg atttgccttt ttcacgactg
     3001 gtgatgcgcc aaacttgttt tttacctggt gtggatactt tttctgcatt atttgataat
     3061 ttgatcgtat cacgcatgct accatcttct tgctcaatag agacaatctt ataaacagca
     3121 cctaaggcag gctgatcata ggctgtgatc agtttggtcc caacacccca aacatcaatt
     3181 ttggcctttt gcatttttaa gttgaggatg gtattttcat cgaggtcatt agaagcatag
     3241 atcttagcct cggtaaaacc agcgtcgtct aactgctgac ggactgtttt tgagaggtaa
     3301 gccaagtcac cagagtccaa tcgaacacct agaaaattaa tcttgtcacc catttctttg
     3361 gctactcgga tagctgttgg cacacctact ttaagtgtat cataggtgtc aacaagaaat
     3421 acacaatctt tatgggtctt agcataagcc atgaaagcat cataatcatt accataggct
     3481 tgcactaaag catgagcatg cgtacctgaa acagggatat caaagcgttt acctgctctc
     3541 acattacttg ttgcatctgc tccaccaatc atcgctgcgc gggttcccca aatcgcagca
     3601 tctagttcct gtgcacgacg ggtgccaaat tccaaaaggg gttcatcctc aatcacagaa
     3661 cgaatacgag cagcctttgt agcaatcaag gtctggaagt taacaatgtt taaaagagct
     3721 gtttcgacca actgacactg acctagaggg ccttctactt gcacaatcgg ctcattagca
     3781 aaaaccaaat ctccttcttt agctgaacgg atggtcaatt ctaatcgtaa ctctttaagg
     3841 taggtcaaaa agttttctgg ataacccagt tcttcaaggt aagccaaatc tgtttctgaa
     3901 aattgaaatt gctctaggta ctccaccatg cgctgtaaac cggcaaaaac agcataacca
     3961 ttgttaaaag gttccttgcg gaaatagact tcaaacaccg catgacgatt atgaatgccc
     4021 tgctcaaaat aaacttgcat catattaatc tgatacaaat cagtatggag agttaaacta
     4081 tcatctttat acataaaggg gactcctttg aattattgtt actattataa catattttaa
     4141 aaaggactct ttggctagga tttagaaata acttgagtta tcgctaaagt aaaaaagaac
     4201 tgatccatca tgacatcctc aaataagaaa gagttaatgg attcagttct atatcgctaa
     4261 ttattattta aatttgacat tgctataaat cccaaaaaca ataatccaaa tcgttgctcc
     4321 aatggcgccg atataggtgg attcttgtaa gaaaagagag ataaagacaa aagcaaagaa
     4381 agcaagggtc aaaggcgttg tcactttata ttttggcatc aaataaccat ctgccataaa
     4441 gtccttagat tgacggtact tccagtgagc aatcatggtt aaggcgtaga tagcaatgta
     4501 tacacctgat gaggaggccg taatgagtga gaacgcatct gcaactcctg gtaggatatt
     4561 aatcaaagct gagataccaa ccacaaccgc tgaagcaata atggcacgac ttggcacccc
     4621 ttgtcgagat aaagtattaa tctttaagcg attggtcaaa gcgtttggag tctcattagc
     4681 aatctgatag agatgacgac cggttgaata aagggttgag ttaagcgctg acgctgctga
     4741 tgtcaagacc acaaagttaa tcaaggctgc tgcccattta ataccaatca atttgaacac
     4801 catcacaaaa ggagattcat caactggtaa ctgatgccat ggcacaattg ccataataga
     4861 gaccaaggct cccacataaa agatcacaat acgggttgga atttcttgaa tagcctttgg
     4921 tagaactttt cttgggttag ccgtctcaga agtggtaatt cccacaaatt cgatagcttg
     4981 ataagcaaag aaaaccattt ggaaggccat aaagaacttt agtttcccat ttgggaacat
     5041 ggaaaaatgg tcaaaaatat tggaaaggct agcatggcct gtgtgagttt caaaacctgt
     5101 caataccatg aaaatagctg ttgcaatcaa agctaaaata gctaaaatct taatcatggc
     5161 aaaccaaaac tctgtttccc caaaaacgcg cacagcaatt aagttgatcg aactaagtaa
     5221 gactaagaaa accaactgaa tcaaccaggc tggccagctt gggaaccaaa attgcacata
     5281 agcacctact gctgtgattt ctgccattcc aataaaaata agggaaatcc aataggatag
     5341 acccgaaaaa taaccccagc ctggaccaat gtatttggaa ataaaattga taaaggtgtg
     5401 ttgatctgga tcataataga gcatttcacc gatggcacgc atcatcataa acatgaaggc
     5461 acctgtaatc atatacacaa aaataataga tggtcctgtt aaggcaatag agcgtcctgc
     5521 ccctaaaaag agacctgttc caatcgttcc tgcaatcgca attaactgca catgacgatt
     5581 ttctaagccc cttaccattc cattttctag ttcgttattg tctgtttgtt cttttataga
     5641 cattctaaac tccattcact aaaatactat ttattatatc cttttttcag aaaattttca
     5701 acatttatct aggaaagata ttaaggaaaa ctgttcttta tatttcttaa aggtcttatg
     5761 caatttagct ttttccaggg aaagacaagg aaaaatgaag gagttttaac cttatgaagg
     5821 gaaactttca aggtagtgat aaacaccttg ccctgcaatt gcaccatctc caacagctgt
     5881 cgtgatttgg cgaaggtctt tttgacgaac atctccaatc gcaaaaatac caggaatact
     5941 tgtcctcata tgatcatctg tgataatcca accttctgaa tcggtaattt ctagatcctt
     6001 taccatacct gtcacaggat tcataccaac atagataaac acacctccaa aagcgtggtc
     6061 agtgacttgg cctgttttca cattttcgat taggacattg gagaccttaa tatcattgcc
     6121 ttgaatttct ttgacaactg aatcccagat aaagtcgacc ttatcattgg caaaagcacg
     6181 atcttgcagt attttttgag ctcttagttg atcacggcga tgaacaacgg ttaccttttt
     6241 agcaaactga gtaagataaa tagcttcttc aactgctgag tcaccaccac caacgaccaa
     6301 aagatcctgg tcacggaaaa acgcaccatc acatactgca caataagaaa ctcctcgact
     6361 agtatagtat tcttcacctg gaacacctag tacacggtat ttagctcccg ttgcaataat
     6421 aaccgtttta gcttcataac tagcatcttc agtcaacaca cacttatagt caccaaaatt
     6481 ttctattttt tgaacaatac cataaatgtt ttcaacgtta aacttctcta aaggttcgta
     6541 cattttcata gctaattctg gtccagatat atgatcgtat cccgggtaat tctctatatc
     6601 aaaagtgttg ttcatctgac caccaggtgc cccttgttca ataatggcaa cagataaatt
     6661 acttctagca gcgtataaag cggcagtcat tcctgctggt cctgaaccaa taattaatgt
     6721 atcgtacatg atttttctcc tttaatctac tcttgccaat attttagcaa tgataatccc
     6781 ttcttgcaat gattaggatt ttatgacaac caaaatactc ataaaagcaa acgataaaat
     6841 tgggatggtt aaaatagcaa ccattagcat ctcataaaga aaagcttgtc tttcaatcaa
     6901 tgttttatct cttttggttt ttgctcgcca taaagtccat attaaacaaa ttaaaatcat
     6961 agtaaggctt gagagaatga gaccttttac ataaaggcta aagatttcta ctaacatatt
     7021 tccacctagt cattatttct ttcccataag tttttctaaa aaacataaca agaaaagccc
     7081 aggaatacct agaccttttt attataacaa aagaatatca ttaaatgtat gtttttgaat
     7141 agcttgcaaa aaattctttg gttcgttctt tttgaggatg tctaaagact tcttcaggtg
     7201 ttccttgttc caagattttc ccttgatcta aaaagagtac tctatctgcc acttggtaaa
     7261 caaaattcat gtcatgactc actaaaacca tggtctgtcc ggatttagca gcatcagtaa
     7321 tagacttttc cacttcgcca actaattccg ggtcaagagc cgaggtcggc tcatctagta
     7381 ataaaacatc tggtttcata gccagagctc ttgctaaagc tacccgttgt ttttgtcccc
     7441 ctgataaatg acgtgggtaa tgatgttttc gatctgctaa accaacctta gccaattctg
     7501 cttgcgccag cttagtcgct tcttggtcag acagtttttt gaccacctta agaccttctt
     7561 tgacattctc aagggctgta cgacgctcaa aaagattaaa ttgttgaaaa accatggcaa
     7621 gtttccgacg taaaataagg acttgctctg tggtaatggt ctcaaaatca accgtaaagt
     7681 caccaatgct aatggatcct gaatctggtt tttccaaata gtttaggcta cgaaggaagg
     7741 tcgatttccc tgctcctgaa gcaccaacta aagcaatcac ttgacctttt tcaatatcaa
     7801 gagccaaact atctaaaact ttttgccctg agaatgtctt gctcaaattt ctaattgtaa
     7861 tcatcaacgc aattctccta acttttcatt tctagcttgt tctggtgctt tgatggccat
     7921 cttgttttca atcaagcgac ctacttgctc catcaaaata ctgatagacc aatagacaag
     7981 agcaacagag atataacgtt caaaataacg gtaatctgat ccgcctagaa tttgagcctg
     8041 ggcaaacatt tcgacaatcc ctgcattaaa ggcaagcgat gttcctttag ttaagccaat
     8101 taacccatta atcaaggttg gaatagccac aacagttgca ttaggaataa tgacacgacg
     8161 gtaaacctgc acagaagtca tgcctagact ttttgctgct tcaatttcac ctgtatctac
     8221 tgataaaatg gctgcccgaa tagtttcact agcgtaggct gcttcattaa aagcaaaggc
     8281 tgtaatggca aaaatagaag ccggaattgc attaacattc caatcaaagc catacttctg
     8341 attgagaaat tttagaaaga ggggaatacc gtagtaggtc aacatcaact gtaccaaaat
     8401 aggagttcct cgcaagaaac tcacaaaaat agcttgaata gggtatagta gcttcacttt
     8461 attaattttg acaagggcaa aaatcaaagc caaaaccaag ccaaaggttg ctcctgatag
     8521 tgtcaaacca agcgtaattg gaagccgttg gataatattt ggaatggcat caaaaacagc
     8581 atgccaacta aaaagttttc catgtggaat cggtgagatg agatgatcat aaaaagccca
     8641 accactggtt aaaaacactg atgtcatgta tttccccttt gtatttgttt gtcttaatat
     8701 tctaacactc ttagacccac atgtaaaata gtaaatccgt attatagcaa taagcaaaag
     8761 ctatgatcac tttttgtgtt aacaaatggt aaacaataca agtagcaggt gtaaaaaagc
     8821 aagattagat gccaattgat cacttacttg ctctttgttc ttaaaaatgt tgttttttgg
     8881 ccttacgctc agcgcggccc ttagcacgat tttcagcacg acgttctttg cgacgttttt
     8941 catcaaccgc ccactgaatt tttttcttgt aacctggttt gacttttttc tttttctttt
     9001 tgaccaaacc aatcatttct gtgtctaatt tttgataggc tttttcacgg ttttgacggc
     9061 gatcacggtc ataggtatct tgaaattctc catttttgag caccttcggt gtaaaggcaa
     9121 tccccatttt ttccagctct ttgatatctg agtcgtcact tggctggtaa agtgtaatgg
     9181 cagttcctgc cataccattt cgacctgttc ggcctacacg atggacaaag aaagacaagt
     9241 cttgtgggat ggcgtcattg atcacatggc tgaccccttc aatgtcaatc ccacgcgctg
     9301 ctaagtctgt ggcaacaatg tattcaaagt ccagtttttt gacttggttc atgatacgct
     9361 tacgttctct tggaggaatg cccccatgaa tcttagccac ttttaagcca ttagctgtta
     9421 aaaaggcatg caaatcatct gcgcgttcct tggtattgac aaaaagcata gccatataag
     9481 gctgcatagt tttgagaatt tctaacagtt gaccattctt atcacgccct tttgtcgaca
     9541 caagccagtt atcaatggta tctgcgataa cggtctttgt cttgatttgt tcaataacag
     9601 gattggtcaa gtattttttc aaaaagggtt gtaatttctg tggaatagtt gctgagaaca
     9661 ccaaaatctg aacagatttt ggaagcgaag ctgcaatctt atctaccgta tccaaaaagc
     9721 ccatgtccat ggtcatatcg gcctcatcca caacaaaggt cgttgcttta tgaatcgcta
     9781 aatcaccaga cttgaccaag tcataaatac gacctggggt cccgatgaca atatgcggct
     9841 ggctgccttt tagtttttca atctgacgga gtttgtctgt gcctccaaca tagttggcca
     9901 aacgaatctc ttcttgggag tgcttagcaa tctgtttaca agcatcaaaa atttgagttg
     9961 ctaattcacg gcttggtgct gtaataacga cttgcacttc tgctttagct tcatcaagtt
    10021 tttcaaaaat gggcaacaaa aaggtgtggg ttttccctga acctgttttt gattccccaa
    10081 ctaagtcacg accggagtta acaataggaa tcagccgctt ctggacctct gttggattga
    10141 caaagccaat ttcttccagc gcttgctgaa cgtattgctt aaaatgataa tctttaaatg
    10201 acatgtttta cctcgttttc ttccatatta tatcattatt gttagagaca agcaaaagga
    10261 gtgggacaac actcacaaaa tcagcatttg tgggtcatct ccactctctt attgatgatg
    10321 ttaatcaaaa tactattggt gactattctt gataatcccc cttagaagac gtataagata
    10381 gctaaaacta gtaaactagc tagacttcct actccccaca aaaaagcatc tacctgccat
    10441 tctgaccact tcttgccttt accagacaag cctcccaatt ccaaatggtg gtggaaaggc
    10501 gtcattctaa aaatacgacg accttctcca tattttttct tggtgtactt gaaataggac
    10561 acttgcaaca tcacagaact tgtttcaaga acataaacga tcccaataat caggagagtc
    10621 cattcttgac gaagcgcaat agaaatagct gccaacatag ctccaagggc taaactaccc
    10681 acatctccca taaatacttt ggcaggcttg tggttaaagc agaagaaacc aagtaaagca
    10741 ccaatcatgg ttccaatcaa taataagaca tcaaattgcc cctgaacgta ggcaataacg
    10801 ccgtaagtca ctaaactaat caccactgag atagaagcta agccatcgat accatccgtc
    10861 aaattaacgg catttgagaa accaaccacc cagaatagaa caaagaatag gtagaaaatt
    10921 cccagcgaca gctgataacc aaacacattg atcgaagaaa tgccacttgg actaacatgt
    10981 aaaaaataga acatcaatcc tccagccaac tgcaaggcta atttttgttt ggctgtcaat
    11041 ccttcattga tttgcttaaa aatttttaaa aaatcatcca aaaatccgat aatcccgtaa
    11101 atgacaacaa ttgataaaat gcctgaaatc aaagctaaac tttgagtgtt tttgatcgaa
    11161 aatagactaa ccaataacga tactgccgta gctactaaaa gaaaaacagt tccccccata
    11221 gtcggtgttc cagctttagc taaatgttgc ttgacatctt catgcatttg ttgcccacca
    11281 atttttttca attgatagaa tttgataaaa taaggcattg tgaaagcaga taccataaag
    11341 gatatgattg ctgcaataag ggttaaaaac atgttaatct cctaaagtaa tggtcatttt
    11401 ttttattttt ttcaaggact taccaacatc aacactttgt ttcataacac gaccagaatc
    11461 tgttccttta aagctgatgt ctatcccagt ccatttagca aaggttttaa cattggattt
    11521 tgtccagcca tacatgtctg gtacctccac aaaacggtct gataatatga gaacttgttg
    11581 gttttctgtt aacgtttgac cgggctgatg cgatactttt ttgatcttgc tgccagtacc
    11641 aaggacaact ggctggacaa gatttcgacg caactcgctt gatgtctcac caggattctt
    11701 tcctacaaag tttggtaatt tataagttgt ttgacgatta gcatctgata ctactggctt
    11761 agttagtgta tcttgcatta agtatgcttc ttccaatact gggttaacca catcttgcca
    11821 aaaaagggga ccaaaatgtt gtggtttagt catagtaaca tacatcaaaa agtctggttt
    11881 atcagctggt accattgcca caaccgaata gacatagtta gtcaatccac catcttgata
    11941 accacttcca tcttctgaac caatttgtgc tgttcctgat ttaacagcaa caggtaaatc
    12001 acccacttta ataattggtc caaatgtttt tgaatagagt gttccaaact cagggtctgt
    12061 tcctacacca atcatgtatt gtcttgtttc actagcggct ttttttgata caggttttcc
    12121 aacaatttct ttatttgccg ttctaaaact tgctgtgtta ggatcataaa tttgactgat
    12181 aaattgtggc tctaacatct caccattatt agaaatagca gtaaaggctc taagcatttg
    12241 aatctgggtt acagaaatcc cttgaccaaa agcgctcata gcttgagtca cgatattatc
    12301 agaaggaaat atacctgcgt cttcatcttt taagccaaaa cgagtaggaa aaccaaagcg
    12361 gaacttcgtc aaataattca tccattttgc attacccatt ttttgttcaa gtttagtcat
    12421 cccaacgtta cttgagaagg caaacccttg tgcataattc atgtactgtc ctgtggaaat
    12481 gccttcgtta atagaccagt cttgaatagt agcatctgca attgttaaac cattagcatt
    12541 gctaaaggtt tcgtttgggt tgaaaacttt atcatcaata gccgctgcca gagtcatcac
    12601 tttcatggtt gagcctggct caaaatttcc ttgatgaagt gcactgtacc atttgtagtt
    12661 cgtattttca agtcctttca gagtatcagc attataagtg gggcgttgtg ttgttgccaa
    12721 aatttcacca gttttagcat taacaagtgt tgcactggcc aactgaccat ttgatttggc
    12781 ttgaaaaaca tccatctggg tttctaagaa ggtctggata ggctcagata gcgttgtgta
    12841 aatatctttg ccatcaatag ctttcttgac agtcttacct gtacccaaga gtgtggtccc
    12901 atttcgatct ttttgataag taataacacc atcttgacct gataaaattt tatcaaaaga
    12961 agcttctaga cctgtttttc caactaaact cttaacacct gtctttttat cttctgttag
    13021 agatgctaag cctataaatt ctgaagcaaa tgtcccattt ggatacatac gaccaggact
    13081 agttgtgaaa gcaattccct tgattttggc atcttccata gccttttgaa tagtagacat
    13141 agtactatat gaaatgccag accctgacgg tccaaacgag acttggaaaa gtcctttacg
    13201 cttaagctgt ttaattacat ctgttttttt cattcccaga tgctttttta aaatatcagc
    13261 tactgtttca tactgagaag gttgtacata taacttttca tctgaagccg agacaaatga
    13321 tttatccaaa attgcgtata tgctataagt cgtagaatcc actgcaatag ctgtaccatt
    13381 tcgatcataa atggtcccac gcttagcttg gatcgtaacg gtttcttgat aaaccttctt
    13441 cgccccttct gacaaactaa ctccaaactt ttgatctgtt ccaataataa tcatgaaatt
    13501 aataatgaaa ataaagaaaa taaagatagt taagagcatc atattttgtc caactcgaac
    13561 gcgattttcg actggagttc tcctatcgcg cacaacataa tctaaaacat atttttgcca
    13621 ttttttcata gattactcga ctttcttgat attattatta cggttgctta agcctgcttt
    13681 accagcaata tctataatac gatcacggcg agataactca tttacttctt gcttggcatt
    13741 attaagctct agtttttgat ccgaaatatg actatttaaa ctagtgattt cttgttgtag
    13801 ctgcaactta cgactttgca ggtaaataat acttactgcc atcgtaatcg ctgttacaat
    13861 gatagcagta taaaaagcct tctcaattct agagaaagtt tttattcgtt tttgcaaggc
    13921 atttgtaact gcctgagttc ttttttcatt tgtcataggc ttatttccga atttttttgg
    13981 caacacgtag cttggctgag tgtgcccttt tattagctgt taactctgaa tgactaggta
    14041 agatcggctt acgtgaaaca agttcaaatg tcggtttcat atcttcagga attagaggaa
    14101 gcccttttgg cacatccacc gtactagctt ctttaaacaa ctgcttggtt aggcgatctt
    14161 ccagagaatg gaaggtaatg actgagatac gaccatcaag ggctaataat tccatagcgt
    14221 cctgaataga ttcatcagcc gctcccaatt catcattgac ttcaatgcga atagcttgaa
    14281 aaatctgttt agcaggatgg ccttttttct tcaactcttt agctggcttt gctgccttaa
    14341 tcaattctgc caactctgtt gttgtctcaa taggcttaat agctcttgct tgttcaattt
    14401 ttcgagcgat ctgcttggag aatttatctt caccatattt gaaaaaaatc ttaaccaaat
    14461 cattgaatgg ataggtattc accacttcgt aagctgttaa gagcgactga cgatccatgc
    14521 gcatatccaa tggagcatct tgtttataag aaaaccctcg ttccctttca tccaattgtg
    14581 ggctggaaac accaaggtcg tataagatac catcaatttc atcaactcca agcgctgtta
    14641 aacgtgcttt gaggtgtcta aaattatctt taataaaagt tacctgtcct ttgtcaatat
    14701 aagatttgag ggtaacttgt gcattgtcaa tagccttttg atcttgatca aaacaataga
    14761 gatgcccttg ttcactaagt ttggacaaca aataagctga gtggcctgaa ccacctagcg
    14821 ttgcatcaac atatatccca ttaggcttga tgtcaagcat atccactgtt tcgtgaagta
    14881 gtacggtcac gtgatgaaat tcttttgtca taactttaat tgtaccatac ttcaaaaggt
    14941 ttacaaatga aaaagtaaga gaaaagggtt tcattcccga gagaatcttc cttttctctt
    15001 actttatcct ttttgttagt tatcagctaa gtcaacttag caagtgctaa tttagccgct
    15061 gcctctagag tttcaactgc ttgtaaaaga tttttagctt ctttaatcac acaacaatct
    15121 gtcagcgggt tgtctaacca aataccaaag gttttatccc aactcgtatt tggtaagtca
    15181 gctaataata gcctatcgac gtctaccagc tatcttcggc agttttgaag agtaacttgt
    15241 aagtctatta ataattggtt gaccttactc attatttcga cgtttgatcc agctgacaag
    15301 cataccatct ccaaaaaaaa aaaaaacaaa atagccccaa tttcggacaa ttttcaattc
    15361 caaatgaatc acctgaatct gatgtaaaag ttcttctaaa gcaacctttg cttcttcctt
    15421 ttctctttca ttagtcatta agggaccttc tagtagctta ttctctgata tgtccatccc
    15481 cattaatata aaatttagtg ctggtcaagg cttctaagcc cattggccca cgggcgtgca
    15541 ttttttgagt agaaatgcca atttcagcac caagcccaaa aacaaaacca tcggtaaatc
    15601 gtgttgaagc gttgacataa acagcagcag catccactaa atcttgaaag gtctctgctg
    15661 ccttaatatc ccttgtgatg atagcttcgg aatggtgact agtatgctga tttatccaag
    15721 aaatagcttc ttccaaagag gaaacaacct taacagacat gatataatct aaaaattcgg
    15781 tctcaaaatc ctctgctttt gcaggcactg cctgctcaaa taacggcaaa gccttgtcat
    15841 ctgcccgcca ttctactggc tgaacctgat tgatcgcttt ttcaagcata ggaataaacc
    15901 ttgctgctac agcttcgtga attaccaatc cctcagctgc attgcaaaca cttgggcgct
    15961 ttgttttagc gttgataaca atcttagtag ccatatctaa gtcagcttga gcatccacat
    16021 agatatgcac attccccaca cctgtttcga tgacaggcac ttttgctttt tccttaacgg
    16081 tctgaattaa tctagcacca ccacgtggaa tcaaaacatc tacataatcc gttgcctgca
    16141 tcaattcttc agcaacagca tgtgaaggat cctcaactag ctggacagca tctggagtga
    16201 tacctgattc ttccagactt tgtcggatca acttcaccaa agccttattt gagtaaaggg
    16261 catcctttcc cccccttagg atgatggcat tattggtttt gaacgccaga ctaaaagcat
    16321 ccactgaaac attcgggcga ctctcaaaaa tcatcgcaat cacccctaga ggaactctct
    16381 tttggaggat tttaaggcca tcgaggttag tgtagccctt aatgacttgt ccgattggat
    16441 cagctaagtc agcaacctgt tgaactccct gtgctatcgc tttaatccgt tctgaagtta
    16501 agcgcaagcg atccatcatg atgtcagaaa taccatgttc tttagcattc gctaaatctt
    16561 tttggttagc ggctaagaga gtctgtgtat cgtcaactaa tacctttgct aaggtgctta
    16621 aaaagcgatt tttaatttgc gtcgacaaag gtgctattaa aagactagct tgttttgccc
    16681 tttgccctaa ccttctcata tcagtcatgc cttacctctt ctatctgctt gaaccaggtg
    16741 cctagcggtt gcccttcaag cactcttaaa atatctctgg gattagctcc attcatcaag
    16801 accatctgtc ctttgttttc aaataccatc tgggcagatt gaattttgct aagcatccca
    16861 cctgtgccaa acttactgcc cgcaccacct gctgacgcaa tgatttcctg cgtaatgact
    16921 gcaacatgac tgcgtaactg cgcatcctca taaatagtag ggtttttatc aaaaaggcca
    16981 tcaatatcag acagcatgat taataaatca gcttttgtaa taccagcaac gacagcagat
    17041 aaacggtcat tatctccaaa tttagtcgca tgatccattt catccacact aaccgcatcg
    17101 ttttcattaa caatcggcac aatgcccaaa ctaatcagac tttcaaaagc attggtaaca
    17161 ttggctagac tttctgggaa aaccaccaca tctctcgtca ataaaatttg tgacacgttg
    17221 gtttggtagt gtgcaaaaat ttgtgaataa agactcatca tggccacctg accaacactg
    17281 gaaactgcct gttgtttagc aagattggtc ggacgttttt ccattttcaa aatatctagt
    17341 ccaaatccca tcgctcccga tgatactaaa ataacttcct tgcccttatt catcaaactt
    17401 gaaatcacaa aagccagttg gtcgattttt tctaaattga ttttacctgt tggtagcact
    17461 aatgaactag tgccaatttt aattacgata cgtgttacat cttcaaattg tcgtttcatc
    17521 atacccaaat tatagcataa aaacagcccc agaggactgt ttttccgaat aatgacctct
    17581 cttcgttaaa gcttctctaa gctttgccag aaggtttttt gaatccataa gtgagcaatc
    17641 cctaaaacca ttagtgtcag acaactcagt agaacactaa tcaacagagg ttgttggata
    17701 atattggcaa tgataacagc tccaaaacct actacacctg tgactattaa attaccaaag
    17761 ataaggccca ttgttagcca ctgcccattt cctctggtaa agagttgtgt catgtcttgc
    17821 cattttaaat ccagaagccg gtagtcacga cgatacataa actccccttg cacaatcaga
    17881 gacagggcgt agccaagaca aaaagcaatc gttagaagag gatgcaggtg caacacaaag
    17941 agaccaaaca caagataaat caccataggc acaatcagtt gcagaccgac gagcaagcaa
    18001 aatttatcca gcaagaattt ttttaacgtt attggtaagc ttttaataaa ggtaaagtta
    18061 tccttttcaa gtgaaatacc tactccaata aagctggttg gtgttgcaca catgataccc
    18121 aaactgaccc caaataataa ggccacccca aagtaatctg gggaaatatg cttaaagaaa
    18181 cctgtgccac gtgacaaact tggaccgata aaaagcatca catacatcag gggcatgaga
    18241 taggtttgtg tcagtaaagt tgcattttgt aacgttaaaa ggtgatgttt tcgcaacaac
    18301 tgcgccagtg attgattctg atgaggacga ttaactggtt ttttagtttg cttggctttg
    18361 ttctcgttac taatataaaa agcctcacga taataatttg gcatcacttt tgtgacaata
    18421 ccatatacca tagctagaac cagtagcaat ggcaaccaaa agttaaggag ggccgcagta
    18481 gaaaacggtg cctgaataac atcatagaat cctttgaaat acggaatagt tgggtaatca
    18541 gtaaatacgc catccgtcat cgtacgcttg ttgttactaa tattaatcgc aaaaattaag
    18601 acgaaagcgc caaaagttga gacaaacatc atgatagttg aaatgagttt ccgcttgcga
    18661 ctccttacaa tgattttgcc cacccaagca ttgatataaa tagctaatac catcgaactc
    18721 actagtaaca ctaaaaagag cacgatagct actaaaatag acaaaggatt tcccaatagt
    18781 tgccagtagg caattaagag aagagagata agaggcatca aaaagacagc acccatccct
    18841 agcgacgaga caatttttgc aatatagagt tcttctgacg ttactggtaa gtgaatataa
    18901 agttttaggt cattactttc ataaaaaatg gtgtaaagag agctaaaggc tgtcaaggtt
    18961 gacatgataa aaaacatagc aacgtcaaag gagaaaagtc ctggataatg actgaaatca
    19021 acaccaataa acataaaaag gtaaatcacc aaaaacatgg caatcattaa ggcctgttgc
    19081 ctcatcatgc ttttataggc tttgaagttt tctttcgggt gtttttcctg acgctttttg
    19141 aggttagcta aactttgtgg attggaataa agaatgttta tcttgataag ttcccaaata
    19201 gtagaccaat tcatcccatc acccctcttc ttgcgcctta cgccctgcga gttcaaggta
    19261 gatgctctcc aaatctttgt caggatggtg ttcttttaac tcatcaatcg ttccaacaaa
    19321 aatcaatttc ccttttttta gaatcccgat acgatcacat aactgctcag cgactgatag
    19381 cacgtgagtc gaaaataaga ccgtatgtcc agaagctgca tgagctttca tcattccctt
    19441 aaggtcaaaa gaagcctgag gatccaaacc tgttaatggt tcatccaaaa tccagatgtt
    19501 aggatttgat acaagagcac caatcacaat cactttttgg cgcatcccat gtgagaaact
    19561 atcaatggtt tgattaactt cttcctttag ttcaaaaagt gttgtcagct gtgctaaccg
    19621 ttcttctcgg tcctcatctg acaccccata aattttagct aaaaactgcc aatactcatt
    19681 tggagttaga ttcaagaaaa tatcaggaga atctggcaca taagcaattt gttttttgat
    19741 agcttctcta ttttctgtca gaagttgacc atccacaaat acttcgccat aactcgcttc
    19801 gataatagaa gtcaaaatgc tgatggtcgt ggttttacct gcaccattat gtccgatgag
    19861 gccaaaaatt tcaccgtcat tgatggtgac gtttaaatcg ctaagagctt ctttgtcgcc
    19921 atacaacttt gaaacgtgtt taaattctat catggtatcc tttttccttt tcttctcttt
    19981 ttctccctag actgatgagg cttcctctaa aatatacttt tccaatgact gcttaaaacg
    20041 gcaaagcgat tttggaagta aaatgtcatt atcaagtaag taattatcca catcttggtt
    20101 tagttggtag gcaacaagaa gtgggttact gtgtttaatt aatctattag aagctgctaa
    20161 aagtagctgc gacaaggcca cattttcacg attttctgga taatcataag cgtgtctaat
    20221 cacatcgtat aagcgctgtc gtttcttttc catttatact cctttatttt tgtactttta
    20281 cgctaataca ataacaatta aattataatt tttatgaatt gttttgtcaa tgacttctta
    20341 tcaaaagaag tgtattaggc agtttgagga aaagaaagaa ctgggtattt tattttaaaa
    20401 aaacagagta aatcaaatga tttactctgt ttgggatgtg taacctagag tgatttgtat
    20461 aactcagttg catttgccac agtgaaacca tattcttcga agatacgatt tcctggagct
    20521 gaagcacccc aagtgtcaat ggtcaatgtt tttcctgcta ggccgacata ttttgcccag
    20581 ccaaagcttg aacctgcttc gatagcgaga cgtttagtca cagctgctgg taggatgctt
    20641 tctttatact ctgctgactg ttcgtcaaag atattttgtg atggcataga taccacacgc
    20701 acatgaatgc cttctgcttc aagagcttct tgagtatcca ttgccagttt cacttctgaa
    20761 cctgttgcaa tgatgatacc atcaaggtcg cctttggctt ctgataaaat gtaagctcct
    20821 ttgttaagac catcttctgc caattctttt gttccttcaa gcactggaag gttttgacgc
    20881 gtcaatacaa gcatagttgg gcgatctgtt tcagcaatgg cacgtttcca agcagtattt
    20941 gtttcgttac cgtctgctgg acgaataacg ttcaagttag gcattgagcg aacacttgcc
    21001 aattgttcaa ttggttcgtg cgttggccca tcttcaccaa cagcgataga atcatgtgtc
    21061 atgacataaa ctgttggcaa attttggagc gctgccatac gaacagctgg aagaagatag
    21121 tttgagaaga caaagaaggt tccgccgtaa acgcgtgtcc cgccgtgaag ggcaataccg
    21181 ttcatggctg cagccatggc aaattcacga acgccaaacc agatgttacg gccttcgtag
    21241 tgacctgatt ggaaatctgt ttcagcctta accatagtat tgtttgaagc tgaaaggtct
    21301 gctgacccac cccagaaaga ggctacttgt tctgaaattt gttggatggc ttgttgactg
    21361 gatacacgac tcgccattga actaccaagt tcgtgcgctt caagttctac ttgagcagct
    21421 tcgttagtaa aggctttttg gtattctgct gctaattctg gatattctgc ttcataagct
    21481 gcaaacaagt cattccaggc ttgttctgct ttttcaccac gcgcttgaag accttgagca
    21541 aagcgctctg ttacttcagc aggcacttca aaatcttgat gagtccattg gtaagctttt
    21601 ttggcaaaag caatgccttc tgctccaaga ggagcgccgt gaacagctga agttccttgt
    21661 ttttcggcac caaaaccaat aatggtttta acttcgatga tggttggttt ctcagtttca
    21721 gctttagctg cttcaatagc agctgcaatt tcttctaaat cgtttccgtc tttcacaagg
    21781 atatgttgcc aaccataagc ttcaaaacgt cctttcacat cttctgtgaa agccatagag
    21841 gttggaccat caagagagat gtcgtttgaa tcatatagca agaccaattt cccaagtttt
    21901 aaatgtcctg ccatacttgc tgcttcttgg ctgacccctt ccataaggtc accgtcacca
    21961 ttcaaagcaa aggtatagtg atcaacgatg tcaaagcctg gtttgttaaa tttagctgct
    22021 aggtgagctt ctgccatggc cataccaaca gcattcgcaa tcccttgacc aagaggtcct
    22081 gtagttgctt ccacaccatc ggtatgatta acttctgggt gacctggtgt tttagaaccc
    22141 cattgacgga agttctttaa atcttctaca gttaaatcat aaccagctaa gtgtaacaag
    22201 ctataaagca tagcacttcc gtgtcccgct gataggataa aacggtctct gtttgaccaa
    22261 ttacggcttg tttttggatt aatgttcatg aagtgattcc aaagaacgta ggccataggt
    22321 gcagcaccca ttggaaggcc tgggtgtcca gaatttgccg cttgaatggc atccattgat
    22381 agggtgcgga cagtatttac tgccaactgg tcaattgcat caaatgtcat aagtaaaacc
    22441 tctctgttta ttacaactaa aattaaacgt tttctattgt ctattgtatc acaaaagtca
    22501 attctttttc agaaaatcct ctaaagtttc taaattcttt tctgctagaa aaataactaa
    22561 aaacgttatg gaataagctc atatcacttt ctttttgact atcaaataag aaagtctgtt
    22621 gacacgttgg ccacagactc tttagcctta ttttttaaag gaagcccaat cttccataaa
    22681 ggttttcaat ccatttgttg tcaatggatg ttgagtcatc ttagcaaata atgggtctgg
    22741 aatcgtcgca atatgtgctc ctaatttagc aacagcttcc acatgggctg ttgtacgaat
    22801 acttgctgcg atgatttctg cttggaaatc gtacaagtca atgatttcac gaagatcgct
    22861 gattaattga taggcatctg tgccaatatc ttccaaacga ccgataaatg ggctaatgta
    22921 agttgcgcct gctttcattg ccattaaacc ttggcttact gtgaaaatca aggtcacatt
    22981 agttttaatc ccttcttttg aaaggatgtt tgttgctttt aacccttctg tggtcattgg
    23041 aattttaacg acgacattgt catgccattt agcaatgctt ctagcttctt ctaccatagc
    23101 atctgctgtt aaccctgtca cttcagcact gattgggcca tcgacgatgt cacagatttc
    23161 tttgataact gtttcaaaat cacgtccttc acgtgagata atggttggat tggttgtgac
    23221 accatccaca acgccaagct cattaatcgc tttaatagcg gctacgttag ctgtatctag
    23281 gaaaaatttc attgtttacc tccaaagttt ttcaatatat taacgctcta attgacaaca
    23341 gtttatcacc tatcgcctag agtacctacc taattattat aaaagtctga cagcccttag
    23401 aaaagaccaa gtatcacaca gagttgtgtt caaaactaga cttagctttt gggctaacca
    23461 gcggttcttc ctcttgttta tttttttgtt gaaagagtga tttgagaaaa tcctctaagg
    23521 cagcaagttc atagggggag ctatactgtt ttaaccggta atagggtaaa tcttgtctcg
    23581 gtaaatagac agtctgatag gtaatcagac agtcataaac tttttgatga tcatagggca
    23641 ttaattgaaa atccctacga tgccccaaat gacgtctaat ggccaattcc gcaatggctg
    23701 cctccacctt attttgcccc aaggcaagcc ctactaaaag aggctcatgg tggcgctcaa
    23761 tggaaaaaac caacaatgct aaaatgtcgt cactcaactg ctgaccgaaa tccgtttcct
    23821 gacccatttg cagcactaaa tggtttatga taacccttaa aagcgctctt ttatcttcgc
    23881 ctactaattg ataaaggtat tggctattgg ttggttggct aaggatagct cctttaaaaa
    23941 agtaagcttt ggaaaaaaat atccccaagc cataaatgat ttcctccttt gtctgatgga
    24001 taatcacatg agccttcttt aaaagccata aggcttctga aatgtgatca gcaataggac
    24061 ctccaaaacc caaactatac ttcatgctgg caataggaag tagagtataa gcatgcaaaa
    24121 agacaaagag gctcttagct tcaaaagcat caaattcaag ggcatagcgt cttaagtaat
    24181 gtaaaagcat gctttctaag cgcttaaaga aaatattaga tgtcataaag tcactatctc
    24241 ttaaaaaatg atcattgtag cctttttgaa aggacattcg cgcttgcgaa atcgccaacc
    24301 aaatcaataa ttgttctaag gcttctgccg ataatgactg gccaatcagc cgctcaatta
    24361 aggtagccaa atgcgaagcg tctaactgat tgaccaaggc gtctatgcct tgtctggtca
    24421 aggtatggcg gaacaattca aaatagaaat aacgccactg aagctcactt cccagttgtc
    24481 tgccttgcga gagcgccaga tcaaattctg ataaaagctg gttgaggtga gctaattgtc
    24541 tgtttagagt agcttcacta accatcagtt caacggataa gttggtgatg ttaaagtgtt
    24601 catggcagta catgtaggtc aatatctgat aggcaaccga ttctttgaga agcagagcta
    24661 ccaaatcctc ccaatggaac tggccatttt cttttaagct cagactgtct ttttctaaaa
    24721 gtaattgaca ggctaaacct tgttctcgac acaaatgatt tagattgtca atgtatttta
    24781 atagggtcac tttagacaag tttgatagcc tcattaggtc ttttagcctt aacgtttctt
    24841 tagcatgata aagggtcacc aagagacgat attgggccct tcgttcctta tccattaagt
    24901 cttcaatctt catggcggag cctcttttca aataatttga gacaagcttc atgaagatga
    24961 taagccaaat cactgtgacc ttgtaaaaag agaaaatctt gaaatgctaa gtcagcgtct
    25021 gtaactttca gagccagagc ctgacctaat tgattggcga tgacaagagc attggttttg
    25081 gataggagct gagcgcctat taaaatccca tccgtttttc tagctattaa tttcagccaa
    25141 aagaggtttt tagaatcccc attttggtac aaatagctac acgtatccat ataaagctct
    25201 gcttcttctt ctgtcacacc aacactcgcg cgataataac caaagtgaga acttcctaat
    25261 accttgaccg tctgtaatgg aggaatagga tatccagcta aatgcagagc cagagcctga
    25321 cctgtcttca ttgcttggtt aatcaaaggt gtatagtaat ccattcccaa tataccaaaa
    25381 tgcaatgaaa ccatgtctcc aatggcatag atattagcct ggctggtctg taagttttca
    25441 ttaaccaaaa tggtcttatc caaagcacaa gccacttgtc cttgcaaaag gtgtgtattt
    25501 ggcctaaagt taatggctaa aatagccaaa tcaccttgga aggtgtcccc ttgctcggta
    25561 tgagcgacaa cttttccctc tatctcatga atagccgtaa catgcttatt attaataaag
    25621 gtgacatggt gaatggacat ttctgccatt acaggggcta tcagttctgc gtcagtctga
    25681 tagaaatctg gacgttcggc tgcttcaatc agtttgaccc gtttgccttg taaggacaaa
    25741 ctgtaggcaa ggtctaagcc aatcaagccg gcaccaataa ccaagacctc ttggctagcc
    25801 tcaatcagtt ttaaactagc ttggctttct tcataatatt tggttaccaa aactttgttg
    25861 gtctgtgacg tctcaatata atgagactgg gggctagcac ccatggcaca aacaagcgtt
    25921 tcataacctt cttcaaaaac tcgtccttga ctgtctttga gaaacaaggt gtttgaggga
    25981 gcttcgatag ctaacacttc tgcttgaata aaccggtggt tagattctat ttgtgctgct
    26041 aggcaggccc ttccccacat agcatcagac aggtcttgaa tgtctcctct gaataattgg
    26101 ttgataccat ttggaatata attgggacag ctttccttat caatgagaat gatttgggaa
    26161 tctggattga ggtccttata tttatcaaca aaggctagac cagcaaagga tgccccgata
    26221 acatgtatgg tctttgtcgt taatgtcata atagtattat tatagcagtt gtttttaaga
    26281 tatgaaagcg ttttacctaa tcctataaag aaaaagcaaa ggagctggcc tatgatagcc
    26341 aaccccttta gtgatggtta ggacatgact tggaaaagca aaactgctaa ggccgctcca
    26401 ataattggtc ctacaacagg tatccaagca taagaccaat cagaatctcc cttgttgttg
    26461 agtggtagaa tagcatgaac tagacgaggt cctaaatcac gcgctgggtt aatggcgtaa
    26521 cctgtcgttc ctcctaagga taacccaatc ccaataacca aggtacctac acagagggtc
    26581 cctagtcctg ctggcatatc atataagcca aatgccaaaa taccaagcat caagacaaag
    26641 gtcccaaaga tttcactcaa taggtttgag ctggtatctc gaatagcagg acctgtcgca
    26701 aatgtcccta aaatatcagc ctgactctca gcagccagat aatgtggcct gaactgaagg
    26761 aataccagag ttgaaccaag catagctccc aatagttggg caaggctata ggcaatggct
    26821 gttgaccagg caatggttcc actcatggca aaagcaaggc taacagctgg attgaggtgg
    26881 gcaggggcaa ctttgccact gataaagact gccacagcaa ctgcaattcc ccagccagtc
    26941 gcaatcacga tccagccaga agcatgggtt ttcgttttgg gcaagacaac ccctgatacc
    27001 acaccatttc ctagtaaaac caataaggct gtacccaaaa attcgccaaa gatatccata
    27061 ttaaccctcc tgatggcctt ttaaggcact caaatcattg tctgcaatca cgcgacgaag
    27121 atcgtcttct tgtgccactc tttcctgatc agaccattca aaatgtttag ccatttcatt
    27181 aatcactggg tcaatcaaag catctaggct atctcgcata aataagaggt gatttgttct
    27241 tctcaagaaa taatctgtcg gtttaagagc catttcataa tccatcgcat aatgtaagga
    27301 caaggtttca gctaaactta acccttcagc tgctgttaat tgacgagtta aggcaaagac
    27361 ttttggcgca ttagaaccat aaaggtttgc caaataccta gcatcatcca tcgaaagacc
    27421 actaagagtt cctaattgag cataggcttc tatttccgaa tctacattgg ctggattgat
    27481 ttcacctcct gaaacaggat aggtttttga attgataagc ttgaaggatt tgccaaactc
    27541 ttctttgagg atttgaataa tccctgtcaa tgctccttca gccattttgc gatagtcggt
    27601 aatcttacca cctgccaagg taaagagtcc attctcatca cggtcaaaac ttgaacctcg
    27661 tgacactgca gacggatcca attctttttc agatgtgctg gtttcaacct gcttaatagc
    27721 tttttcaaca gcttctcggc tatcttcgtg gttaatatag gctttgacag tatcaaccaa
    27781 gtgatcaaaa ctatcatcac tgactttacc gctgttgcca ccattgtagt cagaagcact
    27841 attacctgat aacaaggggc gaagaccagc ccaactgctt tcaatatcat caatggtcac
    27901 gttggcattt ggaaagcggt tattgacaac gcctaacaaa taatccacat cttcttgagt
    27961 aacttgtggg tgctccaagt ctccagtgta gtccgtgtcc gttgttccaa aataagtttt
    28021 ttcttcacgt ggcaagacaa agaccatacg accatcattt aaccctgtgt caacatagac
    28081 aggttgagac actggtaatt tttgacggtc cactaccaga tgcacccctt ttgtagggcg
    28141 catttgatga atcggtcgtc ccttatgaga gaattgacga atctcatcac tccatggacc
    28201 tgtggtgttg atgactaatt tagccttgat aatgatttct tgatctgaca gcaaatcacg
    28261 cgccttcaca ccaataatct taccattgtc atctagcaag aaatcttctg ctttcacatg
    28321 actagcaata agagccccat cacgattagc tcgtttgata ttttcaataa caagccttgc
    28381 gtcattatta cggaaatcaa ggtaaacccc accaccaagc aagccttctt gttttaagtc
    28441 tggttctcgt tttaagactt cttctttggt taacaccttg ttggccgctg gcgtattgga
    28501 cacgcctgct aaaagatcat acaaatccat agcgaccttc aaacggaaca tgctaaaggt
    28561 actaccaggt tcgtcataaa caggtaataa catagggtct ggttttggaa tgtggggtgc
    28621 aatttgttgc accacagccc gctctgacac cgtatctgaa accacctcca catcaaattg
    28681 tttcaagtaa cgaagccccc cgtgaaccaa tttggttgaa cggctagagg ttccttgcgc
    28741 aaaatcttgc atctcaatca gacccgtatc taggccacta gctgccgcct gaagcgccac
    28801 accagcaccc gtaatacctc ccccaataat cagtaggtct aaatctcttt cttgcatttt
    28861 ttggagagct aagcgtcttg tttctcttga aaattccatt ccatcctcct ctagttattt
    28921 tgcatcgtca tctgcatctt cttcttgagt gaaaacttga gttgctttaa cagcgcgctt
    28981 ccaacccttg tataattttt ctttgcgcga ttcattcatg ctagccttaa agagctggcc
    29041 tgtggcattt aactctttca aagcatccat gtcttcccag tagcccacag caagccctgc
    29101 taagaaagct gctcctagag ctgttgtttc taaattttta gcacgggcaa tatcaattcc
    29161 taaaatatca gcctgaaatt gcatgagcat attattcatg gctgcaccgc catccacacg
    29221 gagctgttga atgtcaatac ctgaatccac ctgcatggta tcaataacat ctcgcacttg
    29281 ataggcgata gattgtaagg ttgctttgac aaaatcttct ttgcttgtac cacgtgtcaa
    29341 gccaaagaca gatccacgcg cattagaatc ccagtaagga gctcctaaac cggtaaaagc
    29401 aggcacaaca taaacttcat cgtcactagt tgatgctaga gcgaactgtt cagattctgg
    29461 tgaagtctca atcattttaa gaccatctct caaccattga atggcagaac ctgcaataaa
    29521 gatggaacct tccaaggcat aatgtacctt accaccaata ccatacccaa tggtggtcaa
    29581 aagattatta ctcgataact gcatctcatc accagtattc atgataatga acgaacctgt
    29641 gccataagtg tttttcacca taccaggctc aaaagctagt tggccaaaca aagctgcctg
    29701 ttggtcaccc gccatacctg aaataggcac ttcgccccca taaaaatgaa aggcagctgt
    29761 tttgccataa atttcagaat tggatttaac ctctggaagc atatcttttg gaatatttaa
    29821 aagctctaaa atctcatcat cccatgttaa gtctttaata ttatagagca tggtacgagc
    29881 cgcattggaa taatccgtca catgaacagc accatctgtc aatttccaaa ccagccaagt
    29941 atcaatggtt ccaaaaagta actcgccttt ttcagctcgt tcttgagcac ctggcacatg
    30001 gtccaaaatc caacggatct tggttgcaga aaagtaagca tcaataacaa ggcctgtctt
    30061 ttcatggatc atttttgtat ggccatcttc tttgagttgc tcagcaattg gtgccgtctg
    30121 ccgtgattgc cacacaatag cattataaat aggtacaccc gtttttttgt cccaaaccac
    30181 tgtggtctca cgttggttgg taattccgat tgcttcaatt tggcttggtt tgatgctgga
    30241 ctcaataaaa gcacccgcaa taacagactg aaccgaattc caaatctgat tagcattgtg
    30301 ctctacccaa ccagcgtgtg ggaaaatctg agggaattct ttttggctac tgctaacctt
    30361 ttcccctttt tgattgaaaa taatcgctcg tgaacttgtt gttccctgat caatagccat
    30421 gatatacttt tcttgcgaca ttcattaccc tcctttaagt aagcgttttc ctatttgatt
    30481 ctattatagc taattttatc agaaatatat tatcaagaat ttttaaagct aaaaaaaagc
    30541 tgataagata ggtagcttat cccactagat gatcttgaaa aatccactga tgacaaccac
    30601 gtctcctcat ttctaacgag gtaatctttc ttatcaaaga aaatcaaaag acccaacaat
    30661 cactctgcta atccagagtc atcattgggt cataaagaga actaagcctc aaaggcaaca
    30721 cggtatcaga cagccgtgcc taagaggcaa agacaattgg acacaagagt taaggctgtc
    30781 ttattcatta cagttcttga ttagtcattg attggttcag aagatttttc cacaatatcc
    30841 cctgagttgg cgtcaatggt atagctgtat tcttgatctt tgttttgaaa ctcgatttca
    30901 tacacggctt tgccatcttc attatcttgt gtaactgata gcatttgagc atcagcttcc
    30961 gtaacagaag catcttttaa cgcaattgat ttggctttgt cttctgaaag tttaactttc
    31021 ttactagttt gacttgtctt tggttgatta tccatatgat cgtctttatc atccatatca
    31081 caggctgcaa gactgagtaa agagaggctg gctatggcta gtagagagaa ttttttaatt
    31141 gtcataagta ctaccttctt tctttgattt cttctattat aactcaaaca catggttttt
    31201 cccaatattt tgactataca atataaaaac gtgtggtcac tttgaagtat cataccattt
    31261 aaaataaaag ctaacagtca tcacgataaa caaaaagcag ttcagagctg ctttttgtct
    31321 tatgattttg ggtcatctaa tgaacggccg tgcaagcctt tttcacgttg cacctgtctt
    31381 aatttttcag gggtcacgtc gtttccttct tcgtccacca atttgatgcc ttcgatatgg
    31441 tgtctgacag agcgacgata gccttcaatg tattcttcac ggagttttgc ctgttccact
    31501 ttttcaggtc cagtcaagcc taccgttttt ttctttttag ccagctcatt gatacgagca
    31561 atttttttag gatccatgtt aagccactaa gagcctggaa aaaaagtgta aggcttaaaa
    31621 aactgacttg actctcactg tgagaagcaa tgtttaaagg ccttgttttt tccactcggg
    31681 tactgaactc acttttctag ctaagtcccc aacggctctt tcctttctat ttacttggtg
    31741 tttagttggt taaaagcagc aatggcctta gctttgctta ctaaatctga taaaatagct
    31801 aaacggttgt tcttaagggc ttgatcttct gccataacca ttgtgttatc aaagaaatca
    31861 ttaatcactg ggctaagggc aaagacctgt tctaactgct gggcagcact gcctgctaga
    31921 gtcaagcctt gaatagctgc aaacaaagtg ttttcttgct cattttcaaa gaggctaggg
    31981 tccacctgaa cagaagcgtc cgctttttct gccaaattaa aagcacgtga caaagattca
    32041 actgctggtt tgtaattttc cgtatggctg gctttgacaa gtgcttcagc tgccgctaac
    32101 atttcaggaa ccacaaaggt tgaactctct aaaactgctt cacgaatatc ttttggaact
    32161 gctttgccca tcatcttatc cacacgagca cggataaagt tcatcacatc cgccttattg
    32221 gcataggtca aactatcaaa ggacaagtca tataagctat ctaccagctt atccattggg
    32281 atgcgccatc caaaatgatc tagaatacgg acaatccctt gggttgcacg acgtagagca
    32341 taagggtcgt ttgaaccaga tggaatcaag ccaacagaaa agaatgacaa gagagtatcc
    32401 aatttatctg ctaaagctag gacagcgcca actttggttt caggtagcgc acctcctgca
    32461 gcatcaggta agtagtgttc acggattgct gttgccacag cagcatcttc accagctaga
    32521 cgggcatatt tttcacccat aatcccttgc agctcatcaa attcaccaac catacctgtt
    32581 aaaaggtcaa atttgtaaat ttgggcagca cggtcaacag ctgtgacttc ctcagcagat
    32641 aggttggctt ccttagcaag tgatgcggca atgacacgcg tacgatccat gtgttcagca
    32701 agagagccga ttttttcatg gaaggtcaca ttggtcaatt tggcaaccaa atcagcaatt
    32761 tgcaatttct gatcctcacg ccagaagaat tcaccatctt ctaagcgagc taccaaaact
    32821 ttttcgttcc ctttaataac attttcaatg gcttgatcat tcccattacg aactgataca
    32881 aagtttggca tcaaatgacc ttcttgatca cgtaccacaa aatagcgttg gtggtttttc
    32941 atcgatgtca caagcacttc ctcgggaaca tcaaggtatt tcgcatcaaa acttcccata
    33001 aaggccgttg ggaattcgac caagttcaag acctcgttga gcaagtcagc atcaatatcc
    33061 acttgtactc cttgggccgc ctcaattgcc ttgatttgct ccacaatcat ctcttgacgc
    33121 tctttagcat cagcgataac aaactggctg cgcaaatcag cctcataaga atcagcactt
    33181 gtgatagtgg tttcagtacc taaaaaacgg tgaccacggc tgacgcgtcc agaatgaata
    33241 tccaagaagt caagttccaa ggcctcatca ttcaacagaa ctgtcaaggt gtgaacagga
    33301 cgaatgtatt caaaactatt gttagcccag tgcatgctga ctgggaaggt cattgctgac
    33361 aacacttcag taacgcctag aagcacttcc ttagcaggtt ttccagcttc gtgtttggtc
    33421 acataaacgt attcttctcc tttgacttcg cggaattcga tagcatctgt ggtcaagcct
    33481 ttgccacgaa caaatccttg agcagctttt gagaaattcc catcagcatc aagggcaatt
    33541 ttcttagcag gccctttaaa gtcctcagtc aaatccgttt gctgatcagc taacccagac
    33601 acacgcactg ccaaacggcg tggagttgaa aaggtttgta tatcttcaaa agagagacga
    33661 ttttctgtta agaaagtcgc caggcgctct cccagttgtt tttcacttgg tgtgaccacg
    33721 taggctggaa gttcttccag accaagttcg attagtagat ttttactcat aattaagata
    33781 ccaagggcgt taagtggaca ccatcaaaat agcaaagcga cgcaggtgct tgcacctagg
    33841 aagtcttggt ctttttgaca tagtccgtag cccgtgttca gttcctttct ctaaaaagta
    33901 tctttttgat tgttccctta ggtagggggg acgcaaagtg aaattatcta gtggataatt
    33961 tcagaaaaca aaagtgttcc attcctagtt agccagccta aagtctcgcc aactccctcg
    34021 ttcgataagt aaccttaccg aattgtcact acagcgggag taaccttgac tcggcgacct
    34081 tcggtctccc acttcttgct cgctcttaag attacaaagc tcgcaactag atcatcttta
    34141 aatcgactta ttcgtcatct tcagctagca agattgcgcg tgttgcttca tccaacagtg
    34201 gaaatccaag cttcttgcgt tctgcaacaa aggtcttagc aacgacacgt gccaaattac
    34261 ggatacgagc aatgtagcct gcgcgttctg tgacggaaac agcgccacgg gcatccagca
    34321 ggttaaacgt atgagaacat ttgagcacgt aatcataagc tgggtgaacc aaaccttctt
    34381 ctagggcacg cgaggcttct ttttcaaact tttcaaagtt ttcaagcagc atgtcttggt
    34441 ctgacatttc aaaggaatat tttgaatgct catactcagg ttgcaagaag atttcaccat
    34501 atttaacacc tggtgcccac tcaatatcat agaccgaatc cacttcttga atataggaag
    34561 ctaagcgctc aagaccataa gttacttctg ctgtcactgg agatgtcgca aggccaccaa
    34621 cttgttggaa atacgtaaat tgtgtgattt ccattccatc aagccaaact tcccaaccaa
    34681 gccctgctga tcctgttgag gggttttccc agttatcttc aacaaaacga atatcatgtt
    34741 ctaaaggatt gatgcccaat ttttccaaag aagcaaggta aagttcttga atatttgatg
    34801 gtgatggttt catgaccact tgaaattggt ggtgttggta aagacgattt gggttttctc
    34861 cgtaacggcc atctgcagga cgacgtgatg gctctacata agccgcattc catggctcag
    34921 gacctatagc acgtaagaac gtgtaaggac tcatggtccc agctcctttt tcattgtcat
    34981 aggcctgcat gagcatacaa ccctgatcat tccaatattg ttgtaaggtc aagatgattt
    35041 cttgaaaggt aagtttttta gacatttcgt actcctttga tagtagtaaa atggtatatc
    35101 attgacaatc gtttttttgt catcagtaaa atacctgacg atgttactag catgtattac
    35161 aggtctaggc accaaaaaac cgcattttga tgctcctaaa tcataagacc taggggcgtc
    35221 aaaacgcggt tccaccctaa tttattactt cgtttatata gtatcttttt gggcaatatt
    35281 gacaaatata cttaatcaca ctgcccaaac ggaagcgcca atctgcagtc ctaccattcg
    35341 gctctaacta ccccgaactc gctttagata agatacttgc atcctttttc ctagagtcta
    35401 gtttagcata aagccattag tttgtccatc atgagcttaa ggttttgttc gagtaccatt
    35461 tggaataatc acttccgcta atagcttgtt ttcttctcga atacgtaaat atattactac
    35521 aatgtagcat gggaaaagaa gcatagccgt aattttagca tggcaaagta aggctatgcc
    35581 caccagctca ggggcgatat ttaaaaagta gttaggatgt ttaatcgttt tgaacaacca
    35641 gtgatccaca tatttgtggt tttttgctaa catcaatttt acagtccaaa tgtcacctaa
    35701 gatacgtgtc acttcatata aaacagctac tgataataac atcaacaaaa gacctaaaaa
    35761 actaatgcca tcaaacttaa tttgtttaag cagcgcttca atcaccgcaa acacataaat
    35821 cataatgtga agtaacgtca aaaatttcgt gttctgagca ccaaattcct gtcctccttg
    35881 ggctaatatg gctttttcat ttgttatcga tttcttcaaa aatactaaac gaatagtaaa
    35941 catagctaac atcactaaaa agatggtcac aatacggctc cttattttca ataatagttt
    36001 ctttcacaaa acactaataa agattatagc taaatgataa acctttgtca aaccgttttc
    36061 aaaaaagatt tagcgaatta tggctaaatc tttgtagttt cttaaaaact tgtagtatca
    36121 gggttaggaa tcgctgacat tcctgagaga tagcgaattg tttttttatc ttcttgtgtc
    36181 aagctcacat caaaaatagc catattttcc ttgatgcgct catcatgcac cgattttggc
    36241 aagggaataa aaccttctgc cagcgaccaa gctaaggcaa cttgtgccac tgttttgtca
    36301 tatttattag ctaactgctg catagtctca ttatcaaaaa tctccccttg tcctagagga
    36361 ctccaagctt ccaataaaat ctcatttgcc ttacaataat caaccacttc cttttgatag
    36421 caacctgggg ctaatcgaat ctgattaatt gctggagtta ttttagctgt ctcttgaaga
    36481 gcttctagat gatgcaccat aaaattgctg acgccaatgc ttttaataag ccctgcttca
    36541 accgcctctt ccatatattg ccatgcttgg gcatttgcct ctttccaagt gttacgcaga
    36601 gcttttgggt ttggccaatg gataagatag agatccacat aatccagacc aagacggtca
    36661 atagaagcag ctaaagcgtc ttttgcccct tcataactat gggcgtcatt ccagagttta
    36721 gttgtaataa ataagtcttc tcgtagaacc ccagaatcct tgatggcacg acccacactt
    36781 tcttcatttt tataaatagc tgcagtatca atatgacgat agccagcctt gatggctgct
    36841 aaggtagatt ggtaagcttc ctcaccatcg gctgcttggt aagttccaaa tcctaaaacg
    36901 ggaatctcat aaccacttgt catttttact gttgttacca tcacaaaaac ctccttttat
    36961 caatctctgt aagcgattac tgtaatctat tctatcataa aaaaagaaaa tacaaaaaga
    37021 attggcctgc cagacatagc taccccaatc cttttgtatc tcttaggcat caaaagcttt
    37081 ttgcccattt aaataggttg caacaagtgt taaatcctta tcaagaacaa taaagtcagc
    37141 cgcatgccca gctttgattt gaccacatac gtcgtcaata ccgacagaaa cagctggcac
    37201 ataagttgcc atatgaatgg cttctgccgg agttgcgatt ccccaggcca ctacatttct
    37261 aaggccgtct tttaatttca aaatagatcc tgccaagttt ccactctctt taagacgagc
    37321 agtgccattt gccacaacca cagagaattc ccccaagagg taatcaccat ctggtgaacc
    37381 acctgctcgc atacagtccg taatcatggc tacatgatca tgcccttttt gctgcatcaa
    37441 aatatcacaa gcaactggtg acacatggtg gccatcacaa atcaactctg cgtaagtatt
    37501 tggaagatta taaaccgctc ccaccattcc tggctcacgg tgggtcaatc ctcgcatacc
    37561 attataggca tgaacccaaa cgctagcacc tgcttggaca gcttctttag cctcttgata
    37621 ggttccattt gagtgtccta aagctactgt gacaccttgt ttggtcactg tggagacaaa
    37681 ttctgcgaca ccatcacgtt cgggagcaag ggcaattttt ttgatgagcc ctttagcagc
    37741 tttttgccaa gcatcaaatt cctccaagcg tgggtttttc atataacttg ggttttgagc
    37801 acccttatat tcttcggtaa aataaggacc ttcaaagtaa atgccctgaa tcttagcccc
    37861 tttaacttga tcagcgactg aagcaatagt ccctgatact ttttctaact gctcaaaggt
    37921 agaagttaag gtcgtcggta aaaaagacgt tactcctgtt gctaatagtc cttcactcat
    37981 ttgatgaatc ccttgggcag aattatccat gacatcagct cccgcatagc catggatatg
    38041 agtatccaca agacctggtg caatttgata accggtgtag tcaatgattt gcgcatctgc
    38101 cggaacaatt tctgtccact ccccaaaaac accatcatga agacttaggt agccagccgg
    38161 tttcacctct gttgggtaat aaaaacaatc tgctttaaga tagcatgtca tcttttttcc
    38221 tccctttttt ccttattata cgccttattc tttactttgt aaatggtata taccactttt
    38281 tggattcaaa aaagaaaacg tggatgatca ttcacgtttt ctcttttttt aaagctggtg
    38341 tgaaagtact ttctctgcta aattcaaggc atgatctgtg atgcgggtat agtgggaaat
    38401 aatatcaata aaattaatac ctgcttgtgc cgtacattct ccacaattca agcgcttaat
    38461 gtgggtttta cgtaatcgtc gctctttttc ttcaatttct ttatggcgag tcacaatagt
    38521 ttgcgccaag tctgtatcac tatcaacgat agctctaatg gcatccagtg ttaaacaatg
    38581 cgtcaattga tacatctctg tcaattcttg acgagcagat attgaaaaac caatttgttt
    38641 agatatgatg ccttcaatta gaatacctaa agactcagaa tgatctccaa ttctttccaa
    38701 atcacgtgaa gagtcaagaa taccagccaa gacttcattt tcacttgggc tgagggcttc
    38761 gttagaaata tcaaccaaat aagtggttaa ctcctcatcg atggtatcaa ctgctctttc
    38821 ataacgcttg accttttccc caaatttatc gtcagctgtc ataatataac tgtaagaagc
    38881 ttcaaaagct tgaatcgcat aagaggctaa atgaaccaat tccttgtggg catttcctag
    38941 tgcgatagaa ggggcttggg taataagtaa gcgatctaaa taaagggctt cgtatttgac
    39001 cacttcatct tctcctggaa tgagtctagt cacaatcata gctagtagac taatgaaagg
    39061 aattaataag atggtattag tgatattaaa agagccgtga gaaaaagcga tagtcatctc
    39121 aggtgttaaa ctcaactttg attgtagcca taacatcaat gatgtgaatg ggactaggat
    39181 aatcataaaa ataattgtac cgatcaaatt aaataacaca tgagctgctg ccacacgttt
    39241 agcagcaata tttgaaccta tagctgctaa gacagctgta atgcaggttc ctatatttga
    39301 gcctaacaaa ataggaatag ccccctgtaa ggtcaaaaga ccgcctgaaa acagaccctg
    39361 taaaatcccg ataatggctg ccgatgactg aatcaacatg gtcaaagccg ttccgataaa
    39421 gacaccttgg aagggtttat cacctaatgt cgctaaataa ttttgaaagg ctgacacaga
    39481 tttcaaagga tccatggcat ctcccattag gttcagcgag aagaaaattc ctccgacacc
    39541 aaaaatgata cgcccaaaat tgttgagctt tttattagag gtaaagaaaa gacaggctgc
    39601 accaataaaa atcatgggta aggcgtaatc tcctagttta aaaccaatta aaaacgaagt
    39661 gatagtcgtt ccaatattag cccccataac aattccaatg gcttgtcgca aatttagcaa
    39721 acccgcagaa accaaaccaa ccgtaatcac agttacacct gaactggact gaattaaggc
    39781 agacatggca attccgacta agataccaaa aaagggatta ctggtgtatt tatcaatgta
    39841 ataccttagt ttatctcctg ctgcttgttg cagaccatct cccatatact tgatactgaa
    39901 aagaaagaga cctaagcctc caaagaaatg aaatgcaatg tcttgccaat ttactgacac
    39961 aatattgtcc tcgctcaatt ttttagtcta ttctatttta atgtattacg gtctttatca
    40021 caaggttttt ttaagcgttt ctgtgtatac cgatgtcaac atttgcatat tattggtttg
    40081 ataaggtgtt aggcttttcc gatattttac atcatttgtt tttgcacaaa tcttttcatt
    40141 tcgtttaatt agaggtataa tatggctacg atgaaacaat atcataaagg agattccatg
    40201 actaaatcac aaaaagaggc gctttattgg atgttgagtg ttctaactat cactctaata
    40261 ggtggctcct gccttatttt tggatcccac cctcaaacgc aagataaggt agctaaacat
    40321 tctaaaagtg ctgctagttt actaaaaaaa gcagttaaag cagttaatga cgctgatcgt
    40381 ttagccactg cagctgctat ccaagaagcc cagaaagctg ttgataaatt agcagaatct
    40441 tctaagaaaa aaacgctaca agaacagcta aacgttgcca aagcaaagca agagcaagaa
    40501 gatgcagcta ctcaagcagt taaagctgct gaggagactc tcaatcaaaa tcttaaagat
    40561 atcgcccaaa aagcagttaa cgacttaagt aacaaaggta aaaaagccgc tttacaatct
    40621 cggttagacg ctattttacc agcgaaaccc attattgatg aatttccaag acaaagtgga
    40681 gaaataacag ataactctta ctggacacct ttcccaggag acgtctcaga tacttatgat
    40741 aattcccagt cacctacttt agacccaagc tcagaatctt cagcttcaga tgttacgcca
    40801 caacctagtc atcctgatcc aattccacct cagacctctt cagaaccttc cgactcagga
    40861 gacaagcaat catcaaaaga gtaatacaaa agtttttcgt aaaatcaatc aataaacgtt
    40921 ttagacgact atcttagtga ttagtcttcc tgacatctta aaaaagctag ctcaaatcaa
    40981 aagagtctag ctttttgttt tgttagatag cattaaattt cgtagcccat taaaagtcct
    41041 ccgtcttcag cataaaagct acacaaacct gaggtccttc cagtttgaat cacagcatca
    41101 ggatataaag atttgatttt ttcactgatc tgctcacaaa tttttggatt ttgagcatga
    41161 gcaatgtaaa cttttccgcc tgcataaccc tctttttgaa tttcttctat caaagcagaa
    41221 actgcttttt tttgaccacg cgctttttga agaagttcaa gcgttccttt attgctagct
    41281 ttcccaacca ttctaatatt gagtaagcca attactttac ctactaattt actcagtcga
    41341 ccatttttaa ccaaattatc aaccttggca agcacaaaaa tcaaacgtgt tttttgctga
    41401 taagctgtga tctgtttgac aacttcttca aaggataatc caagattgat caaccgctca
    41461 agctccagta cgagcaaatc catctcgcca cctgctgata aagaatcgat taggtgaata
    41521 ttgacattag gattttcttc aagaagttca tttttagcca gtcgtgcact attatgactg
    41581 ccagataagg tccctgtaag tgtcatcacg ataacattat ctgcacctct ataggcctgc
    41641 aaaaaggctt ctgggcttgg acagctagat gtcgttgctt tagacgactg gtacatagtt
    41701 gtcatcatat tatcgatatc taatccatca tcatctctaa aaatttctgt gccaatctgt
    41761 agggtcaaag gcacacgttc aaagcgcaac tctttggatt gtctagtcaa acttctaaga
    41821 tcacatcctg aatctgttac aattttccaa gtcatttttt atccttcttt ttctctaatt
    41881 tgtgttcagt aacaaagacc agattattaa gccttcgcta agatgtctag gctaatggta
    41941 ataactagtc attaaatcct atgttttatt actagccttt tcaatagtta gtaaagtcat
    42001 ccaatagagc tatacaagga ggtaatgagg ctcctgataa ctaactttag ttgacaaact
    42061 aagacttttc ccataaaatt atatcattat taagtcggtt tttgctactg ataactcatc
    42121 agatgtaaca cttgaaaggt atttgtgatg actgataaag cactctcaaa aagatcactt
    42181 caaaacttaa cacaatttaa taaagaaaca cgacgcatag cacgtgaatc tatggaaatc
    42241 gccttactaa atcttctaga aacaaaacct ttaggtgata ttacgatttc agaattggtg
    42301 acgaaagcag gagtatctcg taacgctttt tatcgtaatt atacctctaa agaagccatt
    42361 atagaacaac tgttagtagg ggttatccgt cgtatttttc gtggactaaa acaatttgat
    42421 attaaaactc aggcttatca agcctggctc tatcttttta ctgaagctaa aaaagaagct
    42481 cagcttctta aaatgatttt caaacatcac ctgcaccatc ttctaacacg attagtcact
    42541 aaacgtctga aagcttatca aaaattaaaa gacaaaaaac aatcgcacta taagcgcctt
    42601 ttttggagca atgctattgt ttctgtcttg acaaactgga tttcagatga catgatcgtt
    42661 cctgccgaag aaatggctgc tatgggcttg cctctattaa cgtaaaaagg ttccttttgg
    42721 gaaccttttt tatataatag ttagtctttt tgagctgcaa gtgcaaactg acggatagcc
    42781 tgagccacac ccgccatatc attagtcaaa gtgactttgt cagctaatgg cttgatagct
    42841 gctgaagcat tttccatagc aactcctaaa ccagcataag ttaacatctc aatgtcattg
    42901 ggagcatccc caatagccat cacttggtca gcagttaaac ccaaatcttc tactaattct
    42961 ttgagagccg atgccttgct gactccctga gggagaattt ctaaaatatt atcttggcta
    43021 cgaacaacat ggaaactctg actaagctga tttctcaccg cacgttcaaa ggcatctagc
    43081 gcagcttttt ctcctaagta catggcttga aaaatcaggc gaggagtgtc cgacagctct
    43141 gctaaggaga caggcttgac aatggtaaat accaaatctc catcttcctg cacaaggtct
    43201 ggcacttctt cttcaagcac caaataatcg ttttcctcag ttaaagtcag gtaaatatct
    43261 ggaaaacttt ggcttagctc ttccagcaat tcaatatctg aaaccttcaa catttttgaa
    43321 tggcgtaatt gccagtcagg actactataa gtactacagc cattattgat aatgaggaat
    43381 tcctcttgtg tcaaacctaa ttggtcaaaa tagggtcttg tccctgactg aggccggcct
    43441 gtacataaga caatttttaa gcctgactga gctgcttctt ggatggctgt gatattctct
    43501 tttggaatct gtttgtcctg gtttaataag gtgccgtcca aatcaattgc aattagttga
    43561 atcatcctat ctttcctctt tccatttgat tttagggagg ttccattttt tacggttgcc
    43621 aatcatgcgt aaagtcgtga gtaaaacaac caaggcataa cattcaatcg ttgaatctgc
    43681 tagtttaaaa tgcaaaacaa tagctgcaag aatagaccac ccagcataga tttcactacg
    43741 caaaacacta ggttttcgcc ctgccagaat atctctgaca acaccaccgc ctgcaccagt
    43801 caacacagct gctacaatga cagcacttaa aggttggtta agacggacag catgcaaggc
    43861 tccttggaca ctaaaagctg ccagaccaat ggcatcagtc aaaacagctg cccgtaccca
    43921 acctctagcc attagcttag gaaaaagcat aatcaaaacc atagcaaaga aagcgcaagt
    43981 gaattctggc ttttgccccc ataaggcctc tataggtaaa ccaattaggg tgtttcgaat
    44041 ggctccgcct ccaaaggctg tcacgaaacc taaaataaaa atccctaaaa tatcaaattc
    44101 ttcttccatg gcaacaatag caccagaaag agcaaaggca atggtcccga tgatatttaa
    44161 aatttcccac atatcaattg tcataagcta ccctattgtc ttttagtctt cttttagttt
    44221 accacgtttt cctttaaaaa ataagtagaa aaagataaaa tgtaaggata aaaaagcaag
    44281 gataaaaccc attttcatcc ttgctacaaa agattcaaac aattatcccc atacttatct
    44341 tatcacatca atgagagttg cttgatagga taaggttgtt ttagattttt tccgtccaag
    44401 ggctagcggt ctcttcgagt accctgttta actcgtcaat attttggaag ccttcagtgc
    44461 atagccactt tcttgcttcg tcctctcctt tagtaatata aactggaacg gatcctgccc
    44521 acgtggcacg cccacacaaa acaccgctaa attgagcacc tgctgctgct gcaaagtata
    44581 atgtctcttg aaaaagtttg gcagatacgc ctgcactcaa atagatataa gggaggtggc
    44641 tggcagcttc ttggtcttga aaagctttaa tagcctcagc ttgactgtaa tggacttcct
    44701 cttcagtaaa accttctaca taagccatat taacaggaac ctctactttt agcacatcaa
    44761 cgccaaaacg cttatccgaa aatactaaca tagcaccgtt aaccttatgt ggcttaagct
    44821 ttgcgtatgc cgcactgttg ttatctgata ttctctcatc ataactcaaa agttcaagaa
    44881 aaaaagggat gtcttcagct gtacattctg aaccaatgcg ttcaatataa gcttgttttt
    44941 gtaaattgat ttgttcatct ccatcaacat cataatagag caaaaattta atagcatctg
    45001 cacctgctgc tttcaaccgt ttgaccgacc attccactaa gcaatcgggt aaacggctag
    45061 tggttgtagc atcataacct gttttttcgt aagctaacag taagcctgtc tgattagctt
    45121 ttaccttagt agccagcaac ccatattctg gatctaataa aatagatgaa gcataaggcg
    45181 tcaattcctc agaaacgaga actttcaatg tttctatctg tgtaactgtc gcttctcctt
    45241 cttgatgtgc tgccatcatt tgcttcagtg cacctcgttg atcaaaagct aaagctgata
    45301 tgattccttg atggctcact ttttctaagt aatgtctttt atttgctgtg attgtcatgt
    45361 gatacctctc ttacttgaag ttgctgatat aattgtttaa aagttgccat agtcatcaaa
    45421 tcttgataat agtgagtagc tagtctctta ggcagactgc ctgagaagtt aagacatcaa
    45481 acggcttagc aatagtactc atgtggctca aagagacttc ggcttcgtcc acatcactgt
    45541 agggaccagc ttccaaaatt tttgtctgca tgccttcatg taaaacagca atacaatttc
    45601 tcgtttcccc tttgattttg aaaaattggt tagaaatgcc ctgttcttgt aactgatgaa
    45661 tgataaagtc acccagttta ctaccactaa atcctgttgc aataactgac cagcttttgt
    45721 taacattctg gtcacattta gctccttatc accagctgtt tttgccgttc tgtcaacacg
    45781 attaaccgtg tccatagcca gacaatctaa aggataggaa atagcgacag aaggatttaa
    45841 ggtaactgtt aaactcatct cttcttccta atcgtgatac tcaccacggt cccatttttc
    45901 taaaaattct gtaaagaaat caggatcttc ttggttagca tgatgagttt ccaagtgggc
    45961 tattttagca attagcttct tattctcttc agtttctttg tattctgcct tgataaaagc
    46021 gtctataata tcacacataa gaagttcacc agtgatttta ccaccaaagc caatcacatt
    46081 ggcattcaat tcttccttgg cataaagcgc tgttgtcata tctcgaacaa gggcggagcg
    46141 aatacctggt accttgttca cggcattatt aatgccaact ccagttccac aaatacaaac
    46201 acccaagtct gcttgaccac taaccacagc ttcgccgact ttttttccaa aaatagggta
    46261 atgggttctt gtatggtcat aagtgccaca gtcaataacg tcatagcctt tagatttcaa
    46321 aaaatcagaa acagccattt tttcgttggt gacaatatgg tcacaaccaa tcgcaatttt
    46381 catcacttta tcctccttta ggccatttta ttgagcatgt caacacgaat ttgatgacga
    46441 ccaccatcgt agggaccagt cacaaaacct ttgacgatat tcttcgctaa ttctggacct
    46501 acaatctctg cccctattgt gatcatgcgg gcattgttgt gaccgcgcgt catgtaagca
    46561 gagcgttcat ctgacacttc agcagcaacc attcctttta attttgtggc taccataaag
    46621 ggacctgctc cgtaagcatc caccataatg cctaaacgcc cttctgcttc attaacggct
    46681 ttagccaccg ctaatgtgtt atcaataaaa tcactgttaa tatcagtcac gtcaataatg
    46741 tcatagcttt cttcttgaag aaaacttttg atcaattctt ttagtgcatt tccgtgtgca
    46801 tctgcaccta aaataatagc catcgtttct ccttttctaa tccaaaccgc ttgccaatct
    46861 agagaagggg gacatgatta cctgtcctta gatcaagatg attgccagca gtcttagttg
    46921 tcttccatta tttctttcaa gaaaagcgct tgcgggtacc cacagagcgc cttgccttac
    46981 atgaggaatg ctcttttctc cctaggggat aaggcaggaa taccttaagc ggttgtctgc
    47041 tattcccaat agttttttag ttagtcacct aacctgattt tatttcattg ttttcgcata
    47101 ctcagcgtta cgtgccttca tttggttagc ataccaagca aagagaccta ggtaaatggc
    47161 cacaaagatg attagcgtga tgattgaggc aatctgacct gttgtcgctt gaccaatcac
    47221 ataaccaaaa attttttcca ttggtccttc aagtgttgaa tgcgtaatca aggaaccagc
    47281 gcttgtacct gctggaaaag cccctacttt tttagccaac tctgtcgcaa atggagcaat
    47341 catagttcct gacaagagga ataatggcaa taagagggaa ccaaaaataa tcatgcgaat
    47401 caaacgacca cgtgtgacca caagaagagc tggtgtcatc cccatagcaa taattcccgc
    47461 caatggtaaa atcccattgc caacttttga taagagaacg gcttcaatca acatgattgg
    47521 ggcaagaata ttggcacagg cccagatttc agcgcgacca gcaatgaaag gccagtccaa
    47581 accgatattg aaacgacgtc catgcattct agcattggca aaattagtaa tcccttgtga
    47641 caaaggctca acagctgcga taaaccaaga accaatcaaa gagaaaagtt ccaaacaggc
    47701 acccgcggta aagcctagac caaaccaatt tttgatagat tcaacagtga aatgaggatc
    47761 tcccataatc ccaatcacaa aacctagagc cattccgata aagaacttag agccccagaa
    47821 gccaattttt ttgttcaatt tagcagcatc aaagtcatat ttatctagcc ccggaaagac
    47881 cttgtcaaaa atcttatcta agaccataat gattggattc atcatgtagt tcatgtgagt
    47941 tgaagtcatt ggtgattgag accctgtccc aagaaggtca tcaaaggtcg gtttcatcaa
    48001 atcagagtta atgattttca ataccccaac aagaataact gccacagtag caatcaaaag
    48061 agacacaaag actggtaaat ggttgcgagc cgcataccac ataatcaata gacctgtgat
    48121 agataaatgc caaatatcaa aaatatcgac gtcaagggtg tccgtttttt tcatgacaat
    48181 catgacaata ttaaccacca gcatcaccag caagaaataa agggtgtaag gggaacccca
    48241 ggtaattgtt gcaagcggtg cccaaccgac atcaataatg tttaaactga tccctgtatt
    48301 tttaacaaag gcctgtaaag actctgaaaa agcccccgtc aaaatcccaa taatggctcc
    48361 aatacctgta agagcgatag ctaacttaat cccgccttcc agtgcctttg tgaatttaac
    48421 cccgaaaatc atggctaaac ctgtcatgac aatcagcatg accacacctg atcccaactg
    48481 aataggaaat cccagaatct tgttaataat gtctaaaaaa ggttgcatca tcttgtctcc
    48541 ttatgttttt attaactcac tgcaaatggt tttctttaat cacgcgctct aattcagcaa
    48601 aaacaggctc actcatgatt gggatacgat agagaatcgg tcctgcttct actgtgggaa
    48661 ttggcatctc aaatcccaag tcagtttttg caatcggcgt aaaaatatca taacgagaca
    48721 ccaattcttc tgtgatgtct ttgaccatca ccgcatcaca atgcacatca tagccacgat
    48781 cagtcatttg gctttcgata gcatctttaa tttgatggct tgagttaaca cctgcaccgc
    48841 aggctgctag aattttaatc atgctgaaac actccttttt ctattaaata gtttgaaata
    48901 gcttgtttat catcttttag actggctaaa tagctcagat tgcctttcgt aataaagaag
    48961 gtaatgagat tggatagaat cgtcgtttga ccctcgtttt gactattgat aataaagaag
    49021 aaatccgtta ccaaacagtc ttcctctgga ttaatcatgt gcttaaaggt aagggcttga
    49081 ctatttctaa catagaccac ttgatcaacc aagcaatact tggtttctgt atgcggaata
    49141 gccgcataca aaatatctga cccatctttg aagtccactt tgagtcctgt cggaaatacc
    49201 gcctcacgct ccactaaagc ctgatggtac tcttgcgtca catacccaac cttttccaag
    49261 tggctagcaa caagatcaaa aagctctggc tgcgtccttg cttcagtaaa tagaatatta
    49321 ggaaacactc cctaccgcct ttctataagt atcaattttt aacaactgtc atctcatcat
    49381 caacaaattg gtaaccgttt acaaaatcat tatagtataa cctttaacat aattcaacat
    49441 ttttacgcaa tattttttgt tatatatgtt tgtttttgtt ttgtttattt tgttttattg
    49501 aaatatgaag gtctatatgc tatgataaac ataagtaaat aaattataga aaggagtccc
    49561 ttagatgtta aaaagagaaa gacttctaaa aattaccgaa atagtcaatg agcaaggtat
    49621 tgttactgtg aatgatatta ttcagacttt aaacgtttct gatatgacag ttcgtagaga
    49681 cttagatgaa ctggaaaaag ccggcaaatt gatccgcatc catggaggtg cacaaagtat
    49741 taccatgcct aataaaaaag agcggtcaaa tattgaaaaa caaaccgttc aaacaaagga
    49801 aaaatgggaa ctagcttcat atgcgacaca actagtcaat gatggtgaaa caatctttat
    49861 tggtccagga acaactttag aatgtttcgc tgagcaatta aaaaatcgtc agattcgcat
    49921 tgtgaccaat agcctccctg tctttaacat ccttcaggac agcgaaacca ttgacctgat
    49981 tcttatcggt ggtgaatacc gatctattac aggagctttt gtagggtccc ttgccagtca
    50041 aaatatctca tccttaaaat ttgccaaggc ttttattagc tgtaatggca tttataaaaa
    50101 cgatattgca acttatagcg aaactgaagg agagattcaa aagctagctt ttaataattc
    50161 tattgaaaaa tacctcttgg tagataacca aaaattcaat gcctacgact tcttcatttt
    50221 ttaccattta aacaacattg atgctgttgt tacagattcg caaataactg aggacgtcat
    50281 cgaacgttat agtcagttca cacaattatt agtagcccac gaaaacaagg agtaaccgtt
    50341 tcatcaagaa tggacagcct gtcagcgcat cgtccttaaa caccttctgg caaaagtgat
    50401 ttgcccccag agaggtgttt ttgttttgct cggaacacac ctgctaacgt cagagtcttt
    50461 atgagtgacc acaaaaaaag aagcccagat taaaaaactg gaacctcttt tgagatgaag
    50521 taagactacc aaaataacct aagaccattt atgtaattca aatttggtat ccttcaaagc
    50581 acgcttgagt aggaacgtta aaggacgtcc tgtcacctta gcctctcctt tttccaaatt
    50641 tacctggacc gattgcacac cggggacagc tgataatttt tcagtaaccg ttcttgcaca
    50701 accgtcacat gtcattcctg taacctgata atgtttttcc attttgtatt ctcctttaaa
    50761 tggtttttcc ttttaaacgc aatgcattca aaacaactga tactgaacta aaactcatgg
    50821 caaaacctgc taacatcggg ttcaataatg ggcctccaaa aagatgaagt aagcccatgg
    50881 ccactggaat catgaggaca ttgtatatga atgcccaaaa taaattttcc ttgacaatcc
    50941 tcatagtcgc tcgactcaat gacagggctt tcaccaaatc cagcatatca ggtttcatca
    51001 gaatcacatc cgccgattca atggcaatat ctgtccctga ccccatagct atcccaatgt
    51061 ctgctacagc caatgccgga gcatcattaa taccatcacc taccattgca acttttctcc
    51121 cttgagattg gaggtttgtt atcacgcctg ctttttgatc aggtaagact tgactaatca
    51181 catctgtaat ccccacttga gaggcaatag ccttagcggt agcatcgtgg tcacctgtta
    51241 gcatgatagt gtgaattccc agttgatgca aagcttcgac ggtagcttga ctatcttctt
    51301 tgacagcgtc agcaatactg aaaagagctc gtagctgccc ctctttagca taatatacaa
    51361 tggtttggcc ttttcctgaa gccttagcac aaactgactg aacagaagct aaatcaatac
    51421 caagggttgc cattaaagta gcatttccaa tcgccaaacg acgcccttca agctgaccag
    51481 tgactcctag gccggttaaa gactcaaact cttccactgg tagactatca taaccagctt
    51541 cctgagcagc acggacaata gcctccccta aggggtgttg agaataggcc tccaaggaag
    51601 cagcttcttg caagatgagg tgttcatctc ccgaaaaagt taggagcttt tgaagacttg
    51661 gtttcccctc cgtaatcgtc cccgttttat caaaaacaac cgtatctacc tgatgggctt
    51721 gttctaagat gtcaccacct ttaaaaagaa taccattttc agctgcacgc cctgttccaa
    51781 ccataatcgc tgtcggggtt gctaaaccaa gcgcacaagg acaagcaatg actagaacag
    51841 cgatggctgt tgtcaaacta aaacgaagac tttcctgcat gaataccaac caaaacaccc
    51901 ctgttaacag agttaatacc aaaaccaccg gaacaaagac acctgagact ctatcagcaa
    51961 tagctgcaat aggtgcttta ttttcttgag cattctcaac tagttggata atttgtgcta
    52021 acaaggtatc attcccaagc ttatctggtt taatcgtgag ggcgcctttc ccattcaagc
    52081 tgcccgcaaa gacattatct ttttctccct tttcaacagg aaaactttcc cctgttaaaa
    52141 aggattcatc caaactgcta tgtccttcca cgataatacc gtcaatagaa actttttcac
    52201 ctggttgaac caggacaagg tcatcatagc taacctcttc taacggcaac aattgccatt
    52261 ggctgtttct ccataccctc acaacagtag ccttcaagga taagagcttt tgaatagctt
    52321 gggaagtacg gcctttagaa cgactttcaa aatactttcc tagaccaatg agtgtcaaaa
    52381 tcactaccac cgattcaaaa taaagggagt gcacaaagtg cgcctggccc atactgattt
    52441 caaccactcc ataaagacta taagcaaaag caaagctggt tgctaaagct accaaggagt
    52501 ccatattagg atatccctta aacaaagctt taaacccatt atggtaataa tgacgattta
    52561 atactaagac tggaatcgtc aagagtagct gactaaagct gtaaacgaaa ggatagcgat
    52621 ctggttgcag aaatgaagga agccataagc ccaccatgtg acccatagct aggtataata
    52681 taggaatggt gaatagggca gaccacaaga cctgagacca aataaccttt aggtcttcgt
    52741 cacgacgacc tgtttgcatg tgttttgcat gttcatcaaa gacttgtgca ccataaccag
    52801 cagcttttac cgcttgaata actttggccg tttctaaatc gtcatcttga taagtaaccg
    52861 tgagtttctc ggtcgctaaa ttcacaacag cctgttctac ttcaggcaat tgattgaccg
    52921 ttttttcaat tgttagagca caagaggcac aactcattcc ctccactaaa aatatctctt
    52981 tagccattaa tacgtctcct ttttctgaca gtggcactgc ccaggcaggc aattacacgg
    53041 cacctcaaga actgcatttt cttttttgac ttctagtagc tcttggaatg cctcaatttc
    53101 ctctaaggtc atcggtaagt cataaagccg ttcaagaagt agacgcgtgt gttgccgctg
    53161 acaaataccg tctaaaacag tcgctagtgc ttctttttgt agcaaagtct catccaaaag
    53221 agcttgataa atataagctc ttccttgccg ataagacgtt aaaagatttt ttttaactag
    53281 cctaccaatg agggtcttaa tagtggaatc tgaccattga tattttttcc ttaaaatagt
    53341 aataatatcg ctacttttaa tatcaccact ggcccacacc acacgcatga cttcccattc
    53401 agcatctgaa atattttgat tcatcaactc acaacctttt aatctacatt tgtagatata
    53461 ttatatcata tttgtctaca tttgtaaata tataaagttt ctaatgattt tatttcttaa
    53521 gttgacaatt ttt
//
LOCUS       DAUDWO010000009        50908 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.009, whole genome shotgun sequence.
ACCESSION   DAUDWO010000009 DAUDWO010000000
VERSION     DAUDWO010000009.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 50908)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 50908)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..50908
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.009"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            195..265
                     /locus_tag="VHC05_000474"
     tRNA            195..265
                     /locus_tag="VHC05_000474"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:227..229,aa:Cys,seq:gca)
     gene            773..976
                     /locus_tag="VHC05_000475"
     CDS             773..976
                     /locus_tag="VHC05_000475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HEQ5401812.1"
                     /translation="MAQGTVKWFNAEKGFGFISTENGQDVFAHFSAIQTNGFKTLEEG
                     QKVAFDVEEGQRGPQAVNITKLA"
     gene            1172..1633
                     /locus_tag="VHC05_000476"
     CDS             1172..1633
                     /locus_tag="VHC05_000476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003085318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CtsR family transcriptional regulator"
                     /protein_id="HEQ5401813.1"
                     /translation="MPTKNTSDSIEEYIKELLAKSGIAEIKRSMLADSFQVVPSQINY
                     VIKTRFTESRGYEVESKRGGGGYIRIAKVHFSDKHHLIGNLMATIEDCISEQVFTDSI
                     QLLFDEHLLTEREGNIILAVASDDVLGTDGSTIRARMLYRLLQRIDRKGSN"
     gene            1633..4077
                     /locus_tag="VHC05_000477"
     CDS             1633..4077
                     /locus_tag="VHC05_000477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011185037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEQ5401814.1"
                     /translation="MIMYSTKMQDIFRQAQFQAARFDSHYLETWHVLLAMVAVDNSLA
                     NMILSEYDAQVAIEEYEAAAILAMGKTPKEQLSRVDFRPQSKTLTNLLAFAQAISQIT
                     RDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDSGNGQPRLADLRKAIERHAGYSK
                     EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQ
                     EVSRMIQVLSRKTKNNPVLVGDAGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMM
                     SVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGSGSGIDSTLDAANILKP
                     ALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYET
                     YHNVSISNEAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKLAPETLTPID
                     QALINGDMKKVSRLLAKEAKGQMRKPTPVTEDDILATLSKLSGIPLEKLTQADSKKYL
                     NLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKTELAKAL
                     AEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLF
                     DEVEKAHPDIFNVLLQVLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFG
                     VKDIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFHSLTQDNMRDVVKIMVRPLIT
                     TLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGH
                     TLKIGLSHGKLTFHIA"
     gene            4255..4545
                     /gene="groES"
                     /locus_tag="VHC05_000478"
     CDS             4255..4545
                     /gene="groES"
                     /locus_tag="VHC05_000478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="co-chaperone GroES"
                     /protein_id="HEQ5401815.1"
                     /translation="MLKPLGDRVVVRFDDEKEQTVGGFVLAGTHKESTRKATVLAVSE
                     TGVRTITGDSVLPSVSVGQEVLVENGHDLEVTVDDEKVSIIRESDIIAIVTK"
     gene            4581..6212
                     /gene="groL"
                     /locus_tag="VHC05_000479"
     CDS             4581..6212
                     /gene="groL"
                     /locus_tag="VHC05_000479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880885.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chaperonin GroEL"
                     /protein_id="HEQ5401816.1"
                     /translation="MAKDIKFSADARAAMVRGVDMLADTVKVTLGPKGRNVVLEKAFG
                     SPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVHEG
                     LKNVTAGANPIGIRRGIETATATAVEALKAIAQPVSGKEAIAQVAAVSSRSEKVGEYI
                     SEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFI
                     LITDKKVSNIQDILPLLEEVLKTNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKA
                     PGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATMTALGQAAKITVDKDSTVIVEGS
                     GSSEAIANRIALIKSQLETTTSDFDREKLQERLAKLAGGVAVIKVGAPTETALKEMKL
                     RIEDALNATRAAVEEGIVAGGGTALITVIEKVAALELEGDDATGRNIVLRALEEPVRQ
                     IALNAGYEGSVVIDKLKNSPAGTGFNAATGEWVDMIKTGIIDPVKVTRSALQNAASVA
                     SLILTTEAVVANKPEPAAPAPAMPAGMDPGMMGGF"
     gene            6463..6729
                     /locus_tag="VHC05_000480"
     CDS             6463..6729
                     /locus_tag="VHC05_000480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5401817.1"
                     /translation="MNHFGEIFKTFRESKGSRLKDVAKAGISTSQLSRFEKGETDLTI
                     STFMLILDESNMPIDEFMYAVHDFHRDDLNELLSKSEAFRNNSR"
     gene            complement(7315..8814)
                     /locus_tag="VHC05_000481"
     CDS             complement(7315..8814)
                     /locus_tag="VHC05_000481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C69 family dipeptidase"
                     /protein_id="HEQ5401818.1"
                     /translation="MINKKISLGVLSILTAFSLQSVSYACTGFIIGKDLTKDGSLLYG
                     RTEDLEPHHNKNFIVRLAKDNPAGEKWKDPSNGFEYPLPEHSYRYSAIPDVTPNKGVY
                     DEAGFNEFGVSMSATVSASANDAIQKIDPYVKNGLAESSMASVILPSVKTAREGVALI
                     AKIVTEKGAAEGNIVTLADKDGIWYMEILSGHQYVAIKFPDDKYAVFPNTFYLGHVDF
                     NDKENTIASEDVEKVAKKAKSYTEVDGKFHIAKSYNPPLNDANRSRSFSGIKSLDPDS
                     KVTYKDSNYELLQSTDKTFSLEDAMKLQRNRFEGLDLKPLDQMALDGKGKPKSKKAVK
                     GYAYPISNPNVMEAHIFQLKKDIPAELGGGVMWLSIGSPRNAPYLPYLGNISRTYEAY
                     QEKSTQYNDKSWYWTVSHINDLVAAHPKPFGTKVIDEMKGLEKTWIAEQEKSTKEISD
                     LVVSDPKAAQEKADKISLDRAEKTFKRLKAIEAKLVKEKPKNKKGLNRS"
     gene            9061..10701
                     /locus_tag="VHC05_000482"
     CDS             9061..10701
                     /locus_tag="VHC05_000482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011055066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401819.1"
                     /translation="MTKPFHHKKLKQITIIAATSLFLFLIGGAFYYSKNHCINAYLKA
                     RSAQSGPVFENIKAYLVWDDTNEQITNDEAMYTKFRRYSQKELRQKKQDLKAASQDSA
                     VQVKSVGRRFWIFPDYRIAIKPMDLTIKTNVPQADVLLNQKKVAVSDSEQFSVKLDRL
                     PTAEYTASIRGKHNGRNIKVNKSYDGDNPVLDLSVSFRTFLVTSNAKQGDLYFDDNHI
                     GTLKDGQLQVEDYPVTENAQAYMKTTFPDGELRSQKYALADVEEGATLEILVTDLLEE
                     DIAGELLVSAFDQLMHYLSTGQDSSNLRSVFEAGSSNAFYRGLKESIKAKFQTDTRKA
                     SRLNIPSILLTTMTQVGKTTYVLDFTATYEFLYDNSTDPEQHTSGHINQDLTGKVTVK
                     KVGQHYLISQSGSKNITVVKEDNQLKAPSVFPESILGTWTGQANGLSIHMSLASDGTI
                     TTKVEDQKGNRSKETRTAKISKVEDKGNGFYLYTPDPGSDISALAPEGGLGGANVKYA
                     YGFKISGKTASPVVWQAALTHEFDYTKPLSGVTLQKQP"
     gene            complement(10790..11791)
                     /locus_tag="VHC05_000483"
     CDS             complement(10790..11791)
                     /locus_tag="VHC05_000483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEQ5401820.1"
                     /translation="MTSVKVLKLSLLLLPPKWLSTLLKNTITGSMKTTNKPSKGFTVT
                     LKNPFEELTVKALLEEQLLIPRKIRHFLRTKKHVLINGHPVNWQSCVKYGDQVKLFFD
                     HEDYPEKIIVMGQAEKVTCLYEDEHIIIVNKPEGMKTHGNDPTELALLNHVSAYTGQT
                     CYVVHRLDKETSGAILFAKTPFILPILNRLLEKRDIHREYLALVHGSLDSPRVTYHHP
                     IGRHRHDRRKRVVDPINGKKAITEVTLVKNFHKTASLLNCQLQTGRTHQIRVHLAHQG
                     HVLFGDPLYSNGKKDCARLMLHAYQLRLKHPLTQEDICVQAKSATFDAVLNAQKARK"
     gene            12367..12747
                     /locus_tag="VHC05_000484"
     CDS             12367..12747
                     /locus_tag="VHC05_000484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HEQ5401821.1"
                     /translation="MKTIRRYDVNEDRGHTGLVEAGDFYYLNYCVGNVGQDIESQING
                     AFDEMERRLALVGLTLDAVVQMDCLFRDVWNIPVMEKMIKERFNGRYPARKSIQTEFA
                     HHGGPQGLLFQVDGVAYSKHISMT"
     gene            12786..15122
                     /locus_tag="VHC05_000485"
     CDS             12786..15122
                     /locus_tag="VHC05_000485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEQ5401822.1"
                     /translation="MRFLELLQKKFFPKAYQEKQFLMHQKTRLTPQHNQKQYSPNANH
                     LDSSATKNSEQDPAIALQRSRAYEGSPKSRPAWLQKLEAVLPSPQHPIRRFWRRYHIG
                     KLLMILIGTLVLLLGSYLFYLSKTAKVSDLQDALKATTVIYDHKGEYAGSLSGQKGSY
                     VELNAISDDLENAVIATEDRTFYSNSGINLKRFLLAVVTAGRFGGGSTITQQLAKNAY
                     LSQDQTIKRKAREFFLALELTKKYSKKDILTMYLNNSYFGNGVWGVEDASQKYFGTTA
                     ANLTLDEAATLAGMLKGPEIYNPYHSLKNATHRRDTVLGAMVDAKKITQTKAQQARAV
                     GLKNRLADTYVGKTDDYKYPSYFDAVISEAIATYGLSEKDIVNNGYKVYTELDQNYQT
                     GMQTTFNNDELFPVSAYDGSSAQAASVALDPKTGGVRGLIGRVNSSENPTFRSFNYAT
                     QAKRSPASTIKPLVVYAPAVASGWSIEKELPNTVQDFDGYQPHNYGNYESEDVPMYQA
                     LANSYNIPAVSTLNDIGIDKAFTYGKTFGLDMSSAKKELGVALGGSVTTNPLEMAQAY
                     AAFANNGVIHPAHLINRIENARGEVLKTFTDKAKRVVSQSVADKMTAMMLGTFSNGTA
                     VNANVYGYTLAGKTGTTETNFNPDLAGDQWVIGYTPDVVISQWVGFNQTDENHYLTDS
                     SAGTASAIFSTQASYILPYTKGSQFHVDNAYAQNGISAVYGVNETGNQSGVDTQSIID
                     SLRKSAQEASQSLSKAVDQSGLRDKAQSIWKEIVDYFR"
     gene            15171..15323
                     /gene="rpmG"
                     /locus_tag="VHC05_000486"
     CDS             15171..15323
                     /gene="rpmG"
                     /locus_tag="VHC05_000486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015912025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEQ5401823.1"
                     /translation="MAQKKASLACVECGSRNYSIGVSSTPKPTRLEVNKFCKYCKTYT
                     LHKETR"
     gene            15337..15513
                     /gene="secE"
                     /locus_tag="VHC05_000487"
     CDS             15337..15513
                     /gene="secE"
                     /locus_tag="VHC05_000487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecE"
                     /protein_id="HEQ5401824.1"
                     /translation="MGFISGTFKVLKDTTWPNRKQRWKDFISVLEYTAFFTVIIYIFD
                     QLLAKSVLALINLF"
     gene            complement(15750..16523)
                     /locus_tag="VHC05_000488"
     CDS             complement(15750..16523)
                     /locus_tag="VHC05_000488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HEQ5401825.1"
                     /translation="MTDRGIVFNIQHFSIHDGPGIRTTVFLKGCPLRCPWCANPESQQ
                     KAPEQMLTSDGLNTKIVGEEKTVDEVIEEVLKDLDFYEESGGGMTLSGGEIFAQFDFA
                     LALLKAAKAAGLHTAIETTAFAKHEQFVTLIDYVDFIYTDLKHYNQLRHQKVTGVRND
                     LIIKNIHYAFQAGKEIVLRIPVIPQFNDSLDDAKAFSELFNQLEIDQVQLLPFHQFGE
                     NKYKLLGREYEMAEVKAYHPEDLADYQAVFLNHNIHCYF"
     gene            16649..17395
                     /locus_tag="VHC05_000489"
     CDS             16649..17395
                     /locus_tag="VHC05_000489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEQ5401826.1"
                     /translation="MNRLERIIQLVSQKKKIDVNSLSEQLDVSKVTIRKDLDKLESKG
                     LLRREHGYAVLNSGDDLNVRLSYNYNIKRRIAEKAAELVQDNDTIMIESGSTCALLAE
                     VLCQTKRNIKIITNSCFIANYIRQYSSCQIILLGGYYQPNSEVTVGPLLKEMISLFHV
                     NRVFVGTDGFNKDLGFMGKDMMRSEGVRYMADAAEEVVILTDSSKFSKTSLVHQLSLA
                     DVNRVITDQALDKQTQELLSASGLVLDFVS"
     gene            17411..18391
                     /locus_tag="VHC05_000490"
     CDS             17411..18391
                     /locus_tag="VHC05_000490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="HEQ5401827.1"
                     /translation="MKEERRRLLAKVAYLHYVQGKSQTLISKEMNIYRTTVCRMLAKA
                     KEEGIVRIEIADYDADLFALEEYVRKQYGLEKLDLVPNQVEDTPMDTLTNVAKTAAEV
                     FRHVVKDGDKIGLSWGATLSCLMDELNPKAMKDVFIYPLAGGPSHINAKYHVNTLVYR
                     LARIFHGNSAFMNAMVIQEDKHLAKGILQSKYFNDILTSWDQLDLALVGIGGEPNSLE
                     QSQWRDLLTSSDHDQLKYEKAVGEVCCRFFDQAGQPVYTGLQDRTIGISLEQLRRVPK
                     TMAVATGKHKAKAILAALKAGFINYLVTDKETMLAVLALDEDIDLNNVLL"
     gene            18678..18998
                     /locus_tag="VHC05_000491"
     CDS             18678..18998
                     /locus_tag="VHC05_000491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEQ5401828.1"
                     /translation="MQVIVPDQIIMGLILNAGDAKQHIYQALKCAKEDDYATSEKEMA
                     LADDALLEAHNLQTQFLAQEASGNKSEITALFVHSQDHLMTTITEINLIKEIIDLRKE
                     LATK"
     gene            19026..19334
                     /locus_tag="VHC05_000492"
     CDS             19026..19334
                     /locus_tag="VHC05_000492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEQ5401829.1"
                     /translation="MIKIGLFCAAGFSTGMLVNNMKVAAEKKGIDCQIDAYSQGKLAE
                     YAPLIDVALLGPQVAYTLDKSETICKENGIPIAVIPMADYGMLDGNKVLDLALSLVKE
                     "
     gene            19344..20648
                     /locus_tag="VHC05_000493"
     CDS             19344..20648
                     /locus_tag="VHC05_000493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEQ5401830.1"
                     /translation="MAKMNMQNIIMPIMKFVNMRGIIALKDGMLAILPLTVVGSLFLI
                     AGQIPFQGVNDAIASVFGADWTEPFMQVYHGTFAIMGLISCFAIGYSYAKNSGVEPLP
                     SGVLSLSAFFILLRSSYVPAEGEPIGDAISKAWFGGQGIIGAIVIGLTVGAIYTAFIR
                     RHIVIKMPEQVPQAIAKQFEAMIPAFVIFTLSMLVYIIAKSVTGGGTFIEMIYDVIQV
                     PLQGLTGSLYGALGIAFFISFLWWFGVHGQSVVNGIVTALLLSNLDANKALMAAGELS
                     LDKGAHIVTQQFLDSFLILSGSGITFGLVVAMIFAAKSKQYKALGKVAAFPALFNVNE
                     PVVFGFPIVMNPVMFLPFILVPVLAALTVYGAIAIGFMQPFAGVTLPWSTPAIISGFM
                     VGGWQGAIVQILILIMSTLVYFPFFKIQDNMAYQNEQASEES"
     gene            20859..23276
                     /locus_tag="VHC05_000494"
     CDS             20859..23276
                     /locus_tag="VHC05_000494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl radical protein"
                     /protein_id="HEQ5401831.1"
                     /translation="MTETKSPYFGHLTDRMTHYREAVLDKKPYIDAERAILATEAYQK
                     HQNKPANLKRAYMLQTILENMTIYIEDESLIAGNQASSNKDAPIFPEYTLEFVLNELD
                     LFEKRDGDVFYITEETKQQLRDIAPFWENNNLRARCGVLLPEEVQVYMETGFFGMEGK
                     MNSGDAHLAVNYQKLLEHGLKGFEERARAAKAALDLTIPENIDKYHFYDSVFIVIDAV
                     KTYAKRYAKLARELAKTAKPERQAELLDIARICDKVPYEPAKTFAEAVQSVWFIQCIL
                     QIESNGHSLSYGRFDQYMYPYVKADLEAGRETEDSIVERLTNLWIKTLTINKVRSQAH
                     TFSSAGSPLYQNVTIGGQTRDKKDAVNPLSYLVLRSVAQTKLPQPNLTVRYHKGLDNT
                     FMNECIEVMKLGFGMPAMNNDEIIIPSFIKKDVSEEDAYDYSAIGCVETAVPGKWGYR
                     CTGMSYINFPKILLITMNDGIDPASGKRFAKGYGHFKDMTSYEELKAAWDATLREITR
                     MSVIVENAIDLGLEREVPDILCSALTDDCIGRGKTLKEGGAVYDYISGLQVGIANLSD
                     SLAALKKLVFEEGRLTPEELWQSLESDFAGERGEEIRQMLINDAPKYGNDDDYADSLV
                     VEAYDTYIDEIAKYPNTRYGRGPIGGIRYSGTSSISANVGQGKGTLATPDGRHAGTPL
                     AEGCSPEHSMDKKGPTSVLKSVAKLPTDEIVGGVLLNQKVNPQTLAKEEDKLKLMALL
                     RTFFNRLHGYHIQYNVVSRETLIDAQKHPEKHRDLIVRVAGYSAFFNVLSKATQDDII
                     ERTEHTL"
     gene            23289..23957
                     /locus_tag="VHC05_000495"
     CDS             23289..23957
                     /locus_tag="VHC05_000495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HEQ5401832.1"
                     /translation="MEYMLDTLDLEAIKKWHHILPLAGVTSNPSIAKKEGDIDFFERI
                     REVRAIIGDKASIHVQVIAQDYEGILKDAAEIRRQCGDSVYVKVPVTTEGLAAIKTLK
                     AEGYHITATAIYTTFQGLLAIEAGADYLAPYYNRMENLNIDPEAVIGQLAEAINRENA
                     DSKILAASFKNVAQVNKSFALGAQAITAGPDVFEAGFAMPSIQKAVDDFGKDWEAIHH
                     RKSI"
     gene            24014..25102
                     /locus_tag="VHC05_000496"
     CDS             24014..25102
                     /locus_tag="VHC05_000496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol dehydrogenase"
                     /protein_id="HEQ5401833.1"
                     /translation="MKVFASPSRYIQGKNALFTNAKTLKQLGDSPILLCDDVVYGIVG
                     ERFESYLIDNGMTPVHVAFNGEASDNEISRVVAIAKENGNDVIIGLGGGKTIDSAKAI
                     ADLLAVPVIIAPTIASTDAPTSALSVIYTDEGAFEKYIFYSKNPDLVLVDTQVICQAP
                     KRLLASGIADGLATWVEARAVMQKNGDTMAGGNQTLAGVAIAKACEQTLFADGLKAMA
                     SCDRQVVTPALENVIEANTLLSGLGFESAGLAAAHAIHNGFTALTGAIHHLTHGEKVA
                     YGTLTQLFLENRSREEIDRYIDFYQAIGMPTTLKEMHLDTATQEDFLKIGRQATMAGE
                     TIHQMPFVISPEDVAAALVAVDAYVTSR"
     gene            complement(25184..25693)
                     /locus_tag="VHC05_000497"
     CDS             complement(25184..25693)
                     /locus_tag="VHC05_000497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidylglycerophosphatase A"
                     /protein_id="HEQ5401834.1"
                     /translation="MSTDHHLREVSYQLLAERGGSLEAIAELVLFLQNDYIPNLTMAE
                     CLESVEAVLAKREVQNAIITGVELDKLAEANQLSEPLLSILKTDQGLYGIDEILALSI
                     VNLYGSIGFTNYGYLDKTKPGIVDKLNHKDGNSCHTFLDDIVSAIAAAAASRIAHNDP
                     AKSAITNQQ"
     gene            26057..26872
                     /gene="sdaB"
                     /locus_tag="VHC05_000498"
     CDS             26057..26872
                     /gene="sdaB"
                     /locus_tag="VHC05_000498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011055059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="streptodornase B"
                     /protein_id="HEQ5401835.1"
                     /translation="MNLLGSRRVFSKKCRLVKFSMVALVSATMAVTTVTLENTALARQ
                     TQVSNDVVLNDGASKYLNEALAWTFNDSPNYYKTLGTSQITPALFPKAGDILYSKLDE
                     LGRTRTARGTLTYANVEGSYGVRQSFGKNQNPAGWTGNPNHVKYKIEWLNGLSYVGDF
                     WNRSHLIADSIGGDALRVNAVTGTRTQNVGGRDQKGGMRYTEQRAQEWLEANRDGYLY
                     YEAAPIYNADELIPRAVVVSMQSSDNTINEKVLVYNTANGYTINYHNGTPTQK"
     gene            complement(27113..27955)
                     /gene="ropB"
                     /locus_tag="VHC05_000499"
                     /gene_synonym="rgg1"
     CDS             complement(27113..27955)
                     /gene="ropB"
                     /locus_tag="VHC05_000499"
                     /gene_synonym="rgg1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982409.1"
                     /note="RopB (Regulator of Protease B) is a paralog of the
                     quorum-sensing transcriptional regulators Rgg2 and Rgg3,
                     which bind short, hydrophobic peptides encoded by genes in
                     their respective vicinities. RopB binds the leaderless
                     short peptide SIP (SpeB-inducing peptide), with sequence
                     MWLLLLFL; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system transcriptional regulator
                     RopB/Rgg1"
                     /protein_id="HEQ5401836.1"
                     /translation="MEIGETVEFIRHSKNISIKQVCGDYLTRQTYYRFIKNNLDISSK
                     KLLYILDNLNVNVDEFLFISNNFKQYKEFIDMDTAKHYFECRNIEGLNHILDSYKDSK
                     SIKEKNLFALVKVLLATLTEEDCLTERTYLSNYLINIETWSHYETVLFNNCMFIFESC
                     FIEMVFSKVILNLDKYNTLRYYGNESIRMFVNMLILFIQRQEYDKASEILAKIEDYQL
                     NDDCLYERCCVSFFDGIIGLINGKEGAEQKCVQILEIFQLLNCKTIHHMFQTYLEAIK
                     HKLS"
     gene            28454..28624
                     /locus_tag="VHC05_000500"
     CDS             28454..28624
                     /locus_tag="VHC05_000500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401837.1"
                     /translation="MDNPKKDKGLSLGVVDPITILITESVINKMRTVPYHLKKLSSTT
                     YCLLADLAYQSA"
     gene            28896..30092
                     /gene="speB"
                     /locus_tag="VHC05_000501"
     CDS             28896..30092
                     /gene="speB"
                     /locus_tag="VHC05_000501"
                     /EC_number="3.4.22.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine proteinase exotoxin SpeB"
                     /protein_id="HEQ5401838.1"
                     /translation="MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAIT
                     FIQKSAAIKAGARSAEDIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILG
                     YSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHY
                     NQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTL
                     SSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDY
                     GPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGV
                     GKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSA
                     VVGIKP"
     gene            30094..30399
                     /locus_tag="VHC05_000502"
     CDS             30094..30399
                     /locus_tag="VHC05_000502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Spi family protease inhibitor"
                     /protein_id="HEQ5401839.1"
                     /translation="MEMHFVRTEPEARRIAETFCAENTQTKTPMRVQQLSYPSDTDHS
                     GGELYIYALSPAGFIIVSGDTRAHTILGYSFDNNLDLNHDNVRSMVEAYQKQINSLD"
     gene            30879..31808
                     /gene="prsA"
                     /locus_tag="VHC05_000503"
     CDS             30879..31808
                     /gene="prsA"
                     /locus_tag="VHC05_000503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase PrsA"
                     /protein_id="HEQ5401840.1"
                     /translation="MKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMKGDTITVSD
                     FYNETKNTELAQKAMLSLVISRVFETQYANKVSDKEVEKAYKQTADQYGTSFKTVLAQ
                     SGLTPETYKKQIRLTKLVEYAVKEQAKNETISKKDYRQAYDAYTPTMTAEIMQFEKEE
                     DAKAALEAVKAEGADFAAIAKEKTIAADKKTTYTFDSGETTLPAEVVRAASGLKEGNR
                     SEIITALDPAISKRTYHIIKVTKKATKKADWKAYQKRLKDIIVTGKLKDPDFQNKVIA
                     KALDKANVKIKDKAFANILAQFAKPNQKQPAQK"
     gene            complement(32079..32315)
                     /locus_tag="VHC05_000504"
     CDS             complement(32079..32315)
                     /locus_tag="VHC05_000504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401841.1"
                     /translation="MTHRFFLTPLSTLWRRLRPKRYSKKVLADEPTSYQPPAAHSPCD
                     DTHQLLEDKSLSDDYLIATSAMRHLWYWGYSQIG"
     gene            32740..35712
                     /locus_tag="VHC05_000505"
     CDS             32740..35712
                     /locus_tag="VHC05_000505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014411903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibronectin binding protein"
                     /protein_id="HEQ5401842.1"
                     /translation="MTNCKYKLRKLSVGLVSVGTMLIAPTVLGQEVSTSASSTKTSAS
                     TNINTNTSTASAGTGTSGTASTTPSVGTSTGGAAGGEAAVASSGGSQSSESAQASTQP
                     QAQTAVAASASTTASPSSSEEKTPKTVTSSTSSTPAASSSSNGNQVTGTEVEPQMMDV
                     EQYKVNKEKTELTVKDDKQQLKIRKDVDELKNKDLFDVKREVKDNGDGTLDVTLKVMP
                     KQIDEGADVMALLDVSQKMTQENFNKAKEQIKRLVTTLTGKSSDGKENHNRRNSVRLM
                     TFYRKISEPIDLSGKTSDEVEKELNKIWDKVKKEDWDWGVDLQGAIHKAREIFRSSYE
                     KKSGKRQHIVLFSQGESTFSYDIKNKNDNKLTKARIEEEVTSSNPLLSWPPIFNHTNR
                     KADMLNDIEYLIKLGERLGITGLDSLKNTLKLASTGSSIAGSLLGSGSLSEYLTLKEY
                     ESRTLKESNFDYTKRVGEGYYYHSFSERIQNELPLKSIIEPQLKGLFKTEDSSWFGRF
                     LNKFSLAKGYQEFKETALLKVLEYLFYKREYIYYNHNLSAIAEAKMAQQEGITFYSVD
                     VTSPNQSANKRTRRSADTPEEKRNKKFDNYLKEMSEGRKFLEGQDVTNKDKFKDTLTE
                     LTIKDEFTEKVTVHKDKEYYKTSLIDDRPKVTHQAPYSSWLNSTKESLTWTISKDQLK
                     KAFESGQPLTLTYKLKVEKEKFKEALKKQQERKKRAASPESENTVTDTIISNKISYKI
                     NNGTDINSNNNKLEDVKMSYSKFKMPIPELDIEVVPIPEKPLVEPMTPLYPAIPNYPT
                     PDIPTPQLPKDEDLEISGGHGPIVDIVEDTGTGVEGGAQNGVVSTQENKDPIVDITED
                     TQPGMSGSNDATVVEEDTTPKRPDVLVGGQSDPIDITEDTQPSVSGSNDATVIEEDTK
                     PKRFFHFDNEPQAPEKPKEQPSLQDSNSLPQAPAYKAAHHLPASGDKREVYFTIAALT
                     IIGAAGLLSKKRRDTEEN"
     gene            35892..37823
                     /locus_tag="VHC05_000506"
     CDS             35892..37823
                     /locus_tag="VHC05_000506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibronectin binding protein"
                     /protein_id="HEQ5401843.1"
                     /translation="MTKKFIKSAVILGLASITISMTQPVEAIANRLEYQEQYERVKKE
                     LDALKEKGPKLGERSLYFRVVNKFLSWFGQVWDPLAIEETDHLLDLIGQVNYLVSNTE
                     FQAPEYQEAKNKLDLAVAGYDLYLSREKGRGDAPDYQVTQLTLEQIATIKTKIQEALK
                     TFAQEVKTIQQTHPDLFPHAYVLNAKTSAIDGKAQPFLVNGYYDVFYKQFLFTNTKDG
                     YNYNKEADNLTSYQNLIKELLELKTKIDQLTTDKPKNDLLETLMWQSKFTLSDFRRTS
                     RLSAYYTQEDYVKKVVLSEEAPNLRTAKEKVKTLKGILHDYYVETNDLEKAKEYHVED
                     ETSPSQPEAPAKPEAPSPSPAPGQKPAEDERSSQATEPANPSKEDSSTDASQGSHDSE
                     NPATDSPSQPQAPDQGNHQSQVPNDKPQTDKTDTPNVPAPPQDTPKVPEAGGQSGPAG
                     NAEEKAPDSGPKESDQSSSKESPSVGEDTTPNQPDVLVGGQSEPIDITEDTITDAPPT
                     VSGHNASTQPQSVVEDTAPQRPDVLVGGQSEPIDITQDTQPGMSGSNDATVINEDTKP
                     KRVFHFDNKESQASEKAAEQKLAPHDSHTTPQASDDTAAPHLPASGDKPEKVFALAAL
                     TMVAAAGLLSKKRRNTDKN"
     gene            37965..38261
                     /locus_tag="VHC05_000507"
     CDS             37965..38261
                     /locus_tag="VHC05_000507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4298 domain-containing protein"
                     /protein_id="HEQ5401844.1"
                     /translation="MTKQDQLIVEKMEQTYETFSPKLANLIEALDAFKEHYEEYATLR
                     NFYSSDEWFRLANQPWDDIPCGVLSEDLLFDMIGDHNQLLADILDLAPIMYKHM"
     gene            38409..38693
                     /locus_tag="VHC05_000508"
     CDS             38409..38693
                     /locus_tag="VHC05_000508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter"
                     /protein_id="HEQ5401845.1"
                     /translation="MKFKKVLVIPALALAATCFLTACGTKKDSKKEEVKEIKMSDIKD
                     DAVSKKTKVVDGEEVTEYTTKDGNVIQIPAGNEEGMESKDAGGSGAPAKN"
     gene            39117..40385
                     /locus_tag="VHC05_000509"
     CDS             39117..40385
                     /locus_tag="VHC05_000509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HEQ5401846.1"
                     /translation="MFQLRKKMTRKQLALLSAGVLTCVVGGSYLIMNHQQQEIVSSVN
                     KVKALTIKEAMEQGKDISLTLAGEVTANNSSKVKIDSSKGEVKDVFVKKGDVVKVGQP
                     LFSYETSQRLTAQSSEFDVQTKANQLQVAKTNAALKWETYNRKVNEINTLKSRYNTAP
                     DESLLEQIRSAEDSVSQALSDAKTADSDVKTAQIELDKANATATTEKGKLEYDTVKSD
                     TAGTIVSLNTDLPNQSKSKKENETFMEIIDKSKMLVKGNISEFDRDKLKIGQKVEVID
                     RKDNSKKWTGKVTQVGNLKAEEKGQGQGQGGNDQQDNPNQAKFPYVIELDQSDKQPLI
                     GSHTYVNVLNNVPEAGKIVLKETFTMAENGKTYVWKVDKNKVKKQEIKTKPFSKGYVE
                     VTSGLTMQDKIAQPLPGMKDGMEVGSIVKP"
     gene            40372..41046
                     /locus_tag="VHC05_000510"
     CDS             40372..41046
                     /locus_tag="VHC05_000510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5401847.1"
                     /translation="MLNLKDIRKSYHLGTEEFAILKGIDLEVNEGDFLAIMGPSGSGK
                     STLMNIIGCLDKPGSGSYAIEGRDVSSLSDNELADLRNQKIGFVFQNFNLMPKLTACQ
                     NVELPLTYMNVPKKERRKRALEMLKLVGLEERSEFKPMELSGGQKQRVAIARALVTNP
                     SFILGDEPTGALDTKTSVQIMDLFKQFNDNGKTIIIITHEPEVAALCKKTVILRDGNI
                     EHSDIE"
     gene            41059..42276
                     /locus_tag="VHC05_000511"
     CDS             41059..42276
                     /locus_tag="VHC05_000511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5401848.1"
                     /translation="MEDIIAALGSILSHKMRSILTMLGIIIGIGAIIAIFSIIEGNTE
                     NTKRQLIGGSNNTINIVFNKKSSIDPKFPDKSNAKKPDYLPFMAEEELSKIQQVKGVK
                     NALISYGIDDKVYHLGQKSSAKISAITKNVAEVRRMTFIKGSDFSDKDFIDQKQVIYL
                     EKSLYESLFPKDDGLGKFVEVMGNPFRVIGVFESKEQSGLTSGTEKIAYIPLHQWYNI
                     NGVVDATPEITIQTYRADDLKPVAKRVSDMLNQTIPKSDYMFGVMNLKEFERQLDNLN
                     KSNFVLLAGIASISLIVGGIGVMNIMLVSVTERTREIGIKKALGARRKLILKQFLIEA
                     VILTLLGGVIGVISGMVSGLIITRSLEYPYILSLFSVVLSLAFCCIIGIVFGLLPAIK
                     ASKLDPIEALRFE"
     gene            42370..43023
                     /locus_tag="VHC05_000512"
     CDS             42370..43023
                     /locus_tag="VHC05_000512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5401849.1"
                     /translation="MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTT
                     SYDLIILDIMLPSLSGLEVLKTIRKTSDVPIIMLTALDDEYTQLVSFNHLISDYVTKP
                     FSPLILIKRIENVLRVSTPDEKRQIGDLLVDETEHSVYWQGTLVKLTKKEYDIIDYLA
                     KRHQKIVTRDQLMDDIWGYSELDTRVLDNHIKNLRKKMTGIPLKTITGMGYLLGERE"
     gene            43020..44408
                     /locus_tag="VHC05_000513"
     CDS             43020..44408
                     /locus_tag="VHC05_000513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HEQ5401850.1"
                     /translation="MRLIKKTFLVINGLIIVVVTSILLVLYFAMPIYYTKVKDKEVKR
                     EFDQTSKQIKGKTVTEIRDILTKKINKDNIWYSLVDSDNQLLYPSLQLLDGVSESKDS
                     QNVNIVTTFDNSYSNVKVMSQKVTLRDGKKMTLLGQSSLQPVTDASKVLLDLYPSLLM
                     FSVTVGSIVAYLYSRTSSRRILSMSQTAKKMVNLEPNLTCTIHGKDEIAMLASDINRL
                     YASLSTSIKSLQKEYEKASDSEREKSEFLRMTSHELKTPITSVIGMIDGMLYNVGDFA
                     DRDKYLRKCRDVLEGQAQLVQSILSLSKIETLASQNQELFSLKSSLEEEMEVFLVLSE
                     LKHLKVTINLEEQFVKANKVYLLKAIKNIIDNAFHYTKPGGQVMIQLKDNQLVIKNEA
                     ETLLTQQQMKQLFQPFYRPDYSRNRKDGGTGLGLFITHQILDQHHLAYRFVVLDQRWM
                     VFTIDFPSHHDD"
     gene            44510..46138
                     /locus_tag="VHC05_000514"
     CDS             44510..46138
                     /locus_tag="VHC05_000514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEQ5401851.1"
                     /translation="MKKRKLLAVTLLSTILLNSAVPLVVADTSLRNNTSSTDQPTTAD
                     NDTDDESETPQKDKKSKETASQHDTQKDHKSSHTHPTPPSNDTKQTDQASSEATDKPN
                     KDKNNTKQPNSSDQSTPSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKA
                     PEKGPEKAVEKTPEPNRDTPKPIQPPLAAAAPVFAPWRESDKDLSKLKPSSRSSAAYV
                     RHWTGDSAYTHNLLSRRYGITAEQLDGFLNSLGIHYDKERLNGKRLLEWEKLTGLDVR
                     AIVAIAMAESSLGTQGVAKEKGANMFGYGAFDFNPNNAKKYSDEVAIRHMVEDTIIAN
                     KNQTFERQDLKAKKWSLGQLDTLIDGGVYFTDTSGSGQRRADIMTKLDQWIDDHGSTP
                     EIPEHLKITSGTQFSEVPIGYKRSQPQNVLTYKSETYSFGQCTWYAYNRVKELGYQVD
                     RYMGNGGDWQRKPGFVTTHKPKVGYVVSFAPGQAGADATYGHVAVVEQIKEDGSILIS
                     ESNVMGLGTISYRTFTAEQASLLTYVVGDKLPRP"
     gene            46216..46467
                     /locus_tag="VHC05_000515"
     CDS             46216..46467
                     /locus_tag="VHC05_000515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401852.1"
                     /translation="MIKKVTTPSQKTKKRVRNGYLLKLGTACLLLSILSYGIGLLGQP
                     SMENTFVGIASVAMLGSVCFFIIFALNRIFDALEDNLRD"
     gene            47143..48744
                     /locus_tag="VHC05_000516"
     CDS             47143..48744
                     /locus_tag="VHC05_000516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEQ5401853.1"
                     /translation="MHVSKLFTSQQWRELKLISYLTENSNAIGVKDKELSKALNISML
                     TLQSCLTNMQFMKEVGGITYKDGYINIWYHQCCGLQEVYQKALRESPSLKLLELLFFR
                     DFSSLEELAEELFVSLSTLKRLIKKTNTYLSHTFAISIVTSPVQVSGDERQIRLFYLK
                     YFSEAYKISEWPFGDILNLKNCERLLSLLIKEVDVKVHFTLFQHLKILSGVNLIRYYK
                     GYSCSYNNKKTSHRFSQLIQHSSEIQDLSRLFYLKFGLHLDEYTIAEMLSNHLNDKLE
                     IGCAFEIINQDPTSGGRQVTNWIHLLDEMEIKLNLSITNKYEVAVTLHNASVLNEEDI
                     TANYLLFDYKKSYLNFYQKEHPRIYEAFVTSVEKLMQADNAQVSKELINQLTYCFFIT
                     WENSFLKVNQKDEKVRLLVIERSYNSVGNFLKKYIGEFFSITNFDELDCLTIDLVEIE
                     KQYDVIVTDVMVGKSEELEIFFFYKMIPEAIIDRLNEFLNVSFTDNNVMVKNLEAPSS
                     SKSHSDKEVQKPEKPDNSVKQATSS"
     gene            48932..50098
                     /gene="mrp"
                     /locus_tag="VHC05_000517"
     CDS             48932..50098
                     /gene="mrp"
                     /locus_tag="VHC05_000517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M-related protein Mrp"
                     /protein_id="HEQ5401854.1"
                     /translation="MSKRNPNKLYSLRKLKTGTASVAVALTVLGTGLANTTDVKAESR
                     RYQAPPRVLLQGKEANKVFEERKALEKQARDLGDTINHMSQTISEQSRKIAALKSEAE
                     LKNQQALEALNNKNKQISDLTNENAQLKEAIEGYVQTIQNASREIAAKQQELAAAKSQ
                     LEAKNAEIEALKQQDASKTEEIAKLQSEAATLENLLGSAKRELTELQAKLDTATAEKA
                     KLESQVTTLENLLGSAKRELTDLQAKLDAANAEKEKLQSQAATLEKQLEATKKELADL
                     QAKLAATNQEKEKLEAEAKALKEQLAKQAEELAKLKADKASGAQKPDTKPGNKEVPTR
                     PSQTRTNTNKAPMAQTKRQLPSTGEETTNPFFTAAALTVIASAGVLALKRKEEN"
     gene            50325..50447
                     /locus_tag="VHC05_000518"
                     /pseudo
     CDS             50325..50447
                     /locus_tag="VHC05_000518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285743.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif.; incomplete; partial in the middle
                     of a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
BASE COUNT        17035 a         9916 c        10277 g        13680 t
ORIGIN      
        1 taattattat taaagcgttt acaaaaaact tttttgattc cgttaaggca acttaatatt
       61 atggttacct aatcactaat attgtaacct attttggcat gagatcaggg aatggctgtt
      121 atattaattg gatatgtctt gtgcaaatag tgcttgacgg atttgtggaa ttagggtaaa
      181 ataatctttg ttgcggcggt atagccaagt ggtaaggcac ggctctgcaa aagcttgatc
      241 gtcggttcaa atccgtctac cgccttttat atacaaaaca agccttgatt aacttcgtga
      301 aaacgttgtt aaatcaaggt ttttattttt tgcgacagga taaaaaaaga gaaaaaaaga
      361 aataaagtcg gtcaaatttc ccgaagatgt cttttatagc ctgattatta ggtatgaaaa
      421 atactatggc caaaattggt aaacgattgc aaataaaggt cagagttctt acccccttaa
      481 acgatatgcg ttaaaagtta gttgaactgc cgtgcaccta acgatagaca cggtgatgtg
      541 agagcgagta gagttgaatc tctacttgtt tatcttacca tagtcagctt tataaagtaa
      601 ccacccatta caatgcaact atattcttaa tgtttttaag catgttattg acaagtgtta
      661 taaaatgtgt tactcttagt gagtaaatta gtttttgagt tagtatttgt gtttcaacat
      721 ctttatttct ctctattttt acaaatgatt tttagaaagg aagtggatgt atatggcaca
      781 aggtacagta aaatggttta acgctgaaaa aggttttggt tttatttcaa ctgaaaacgg
      841 tcaagatgtc tttgcacatt tttcagccat ccaaactaat ggttttaaaa cgttagaaga
      901 aggacaaaaa gtggcatttg acgtcgaaga aggtcaacgt ggacctcaag cagtcaatat
      961 cactaaattg gcctaatctg gttaaagtaa ctaaagagaa gcagatgttg gaaacagcaa
     1021 ctgctttttt gatttctacc agttaccttt aatgattaag agttgcgttt aaggtcttgt
     1081 atttgttata ataatagtca gttttagtca aaatgtattg acgtggtgct actaagtttt
     1141 tagagtagcc cgcaagcaaa ggagtgacag catgccaacc aaaaatactt cagacagcat
     1201 tgaagagtat attaaagaat tattagctaa gtcaggaata gcagaaatta agcggtccat
     1261 gctagcagat tcgtttcaag ttgtcccaag tcagatcaac tatgtcatta aaacccgttt
     1321 tacggagagt cgaggctatg aagtagagag taaacgaggt ggtggaggct atattcgtat
     1381 tgccaaggtt catttttcag acaaacacca tctgattggc aatttaatgg caactattga
     1441 agactgtatc agtgagcaag ttttcacgga ctcgatacaa ttgctttttg acgaacactt
     1501 attgacagag cgtgagggaa atatcatttt ggctgtggcg tctgatgatg ttttaggaac
     1561 tgatggttca actattcgtg cacgaatgct ctatcgctta ttgcaacgaa ttgacagaaa
     1621 gggaagcaat taatgattat gtattcaacg aagatgcaag acatttttag acaggcgcag
     1681 ttccaagctg ctcgctttga tagccactac ctggaaactt ggcatgtttt gttagctatg
     1741 gtagctgtag acaattcttt agcaaatatg attttaagtg aatatgatgc ccaagtcgcc
     1801 atagaagaat atgaagctgc agctatttta gccatgggca aaacccctaa ggaacagttg
     1861 tctcgtgtag acttcagacc tcaatctaaa actttgacta acttgttagc ttttgcgcag
     1921 gctattagcc aaatcactag ggatcaagaa gtcggctctg agcatgtctt atttgctatt
     1981 ttattgaatc cagatattat ggcgagtcgc ttgttagaaa tagcaggcta tcagataaaa
     2041 gatagcggca atgggcagcc gcgattagct gacttacgaa aagcaataga acgtcatgca
     2101 ggttacagta aggaaatgat caaggctatt cacgaactac gtaagcctaa aaaaacgaaa
     2161 acacaaggga ccttttcaga tatgatgaag ccaccaagta cagctggtga gttgagtgat
     2221 ttcacaagag atttgactga aatggcaaga caaggtttgt tagaatcggt gattggacgt
     2281 gaccaagaag tatctcgtat gattcaggta ttaagtcgta aaacgaaaaa caatcctgtc
     2341 ttggtaggtg atgcaggtgt tggtaaaacg gcgcttgctt atggccttgc tcaacggatt
     2401 gcaaatggcg ctattcctta tgaacttaag gagatgcgtg tcctagaatt agacatgatg
     2461 agtgtggtag caggaacccg ttttcgtggg gattttgaag agcgcatgaa tcaaatcatt
     2521 gatgatattg aagctgatgg tcagattatt ctttttgttg atgaactaca tactattatg
     2581 ggttctggca gtggtattga cagtacactt gatgcggcta acattttaaa accagcatta
     2641 tcgcgcggca ctcttcatat ggttggagca acaactcaag aagaatatca aaaacatatt
     2701 gaaaaagatg cagctctttc gcgtcgtttt gctaaaatat taattgaaga acctaataca
     2761 gaagatgctt atcagatttt gatgggccta aaattatctt atgagaccta ccataatgtc
     2821 tcgatatcaa atgaagcagt taaaacagct gtaaaaatgg cacaccgtta tttaaccagt
     2881 aaaaatctcc ctgattcagc tatcgattta ttagatgaag ctagtgctgc tgtgcaaaac
     2941 atggtgaaaa aattagcacc tgagacttta acaccaatag accaagctct tatcaatggt
     3001 gatatgaaaa aagtatctcg cctcttagct aaagaagcaa aaggtcagat gagaaaacca
     3061 acaccagtga cagaagatga tattttggca accttgagta agttatcggg aattccactt
     3121 gaaaaactga cgcaagctga tagtaaaaaa tacctcaatt tagaaaaaga actgcataag
     3181 cgtgtgattg gtcaggatgc tgctgttacg gctatttcaa gagccattcg tcgcaatcag
     3241 tcaggtattc gaacaggaaa acgtcctatt ggatcattta tgtttcttgg cccaacagga
     3301 gtaggtaaga cagaactagc aaaggccctt gcagaagttc tctttgatga tgaagcagcg
     3361 cttattcgtt ttgatatgtc tgagtacatg gaaaaattcg cagcgtctag gcttaatgga
     3421 gcacctcctg gttatgtcgg ctatgatgaa ggaggtgaac tgacacagaa agttagaaat
     3481 aaaccttatt cagtcttgct ttttgatgaa gtggaaaaag cacatcctga tatttttaac
     3541 gttctccttc aagtattaga tgatggtata ttgactgata gtcgtgggcg taaggtcgat
     3601 ttttcaaata ctattattat catgaccagc aatcttggcg caacagccct gcgcgatgat
     3661 aaaacggtcg gttttggggt caaagacatt caccaagacc atcaagctat ggagaaacgt
     3721 attttagaag aattaagaaa aacttaccgc ccagaattta tcaatcgtat tgatgaaaaa
     3781 gtggtctttc atagtctgac ccaagataac atgcgcgatg tggttaaaat catggtacgg
     3841 cccctgatta ctacattggc agaaaaaggt attaccctta aaattcagcc tttggccttg
     3901 aaacatttgt ccgaggtcgg ctatgatgag catatggggg caagaccatt acgtcgaacg
     3961 ctgcaaactg agatagaaga taagctatca gagcttatcc tttctcgaga attgacaagt
     4021 gggcatacgc taaaaattgg attatcacat ggcaaattaa cgtttcacat agcttaattt
     4081 ccatataaaa ggtggatcat ccttgatgtc accaaaaaaa gaggttattc ttacaaaaat
     4141 aacttctttt ttcttgacta tttttgacca agtgataaaa tagaatataa agttagcact
     4201 cgatgaacat gagtgctaac tttactaaag attcttttat tggaggaaaa tttcatgtta
     4261 aaaccattag gtgaccgtgt ggtcgtaaga tttgatgatg aaaaagagca gacagtcggt
     4321 ggttttgtcc ttgcaggcac tcataaagag tcaacacgaa aagcgacagt cctcgctgtc
     4381 agtgaaacgg gtgttcgcac tattacaggt gatagcgtgc taccttcagt ttcagtgggt
     4441 caagaggttt tagttgaaaa tgggcatgat ttagaagtaa ccgtagatga tgagaaagtt
     4501 tctatcatcc gtgaatctga catcattgct attgttacaa aataaaacga caaatctcta
     4561 aatagaaaga aggattgaat atggcaaaag atattaaatt ttcagcagat gcgcgtgctg
     4621 ccatggtgcg cggagttgat atgttagcag ataccgtcaa agtaacgctt ggtcctaaag
     4681 ggcgcaatgt tgttcttgaa aaagcttttg gttctccctt aattactaat gacggggtaa
     4741 ccattgctaa agagatcgaa ttagaagatc attttgaaaa catgggagca aaattggtgt
     4801 ctgaagtggc ttctaaaacc aatgatattg ctggtgatgg gacgactact gcaacagttt
     4861 tgacacaagc cattgttcat gaaggactaa aaaatgtgac agcaggtgct aatccaattg
     4921 gtatccgtcg aggcattgaa acagcaacag caacagccgt tgaagccttg aaagccattg
     4981 ctcaacctgt atctggcaag gaagctattg ctcaggtcgc tgcagtatca tcacgctctg
     5041 aaaaagttgg agagtatatc tcagaagcta tggagcgtgt gggcaacgat ggtgtgatta
     5101 ccatcgaaga atctcgaggt atggaaacag aacttgaagt ggttgaaggc atgcaatttg
     5161 accgtggtta cctgtctcaa tacatggtca cagacaatga aaaaatggtt gcagaccttg
     5221 aaaacccatt tatcttaatc acggataaaa aagtgtcaaa catccaagac attttgccac
     5281 tacttgagga agttcttaaa accaaccgtc cattactcat tattgcagat gatgtggatg
     5341 gtgaagccct tccaaccctt gtcttgaaca agattcgtgg tactttcaat gtggttgctg
     5401 tcaaagcgcc aggatttggt gatcgtcgta aagctatgct tgaagacatt gctatcttga
     5461 caggtggtac agtgattaca gaggatctag gacttgaatt aaaagatgct acaatgacag
     5521 cccttggaca ggctgctaag attacagttg ataaagatag cacagtaatt gttgaaggtt
     5581 caggaagttc agaagctatt gctaaccgta ttgcactgat taaatcgcaa ttagagacaa
     5641 caacttctga ctttgaccgt gaaaaactac aagaacgttt ggcgaaatta gctggtggtg
     5701 tagctgttat caaagtagga gctccaacag agacagcttt aaaagaaatg aaacttcgca
     5761 ttgaggacgc tctaaatgct acacgtgcag ccgttgaaga aggtatcgtt gctggtggtg
     5821 gaacagcact tattacggtt attgaaaaag tagcagctct tgaacttgag ggcgatgatg
     5881 ctactggacg taacattgtg cttcgtgctc tagaagagcc tgtacgtcaa attgctttaa
     5941 atgctgggta cgaaggctcc gtagttattg acaagttgaa aaacagccct gcaggaacag
     6001 gatttaatgc tgcaacaggt gagtgggttg atatgattaa aacaggaatc attgaccctg
     6061 tcaaagtaac acgatcagcg cttcaaaatg cagcttctgt agctagtctg attttgacaa
     6121 cagaagcagt tgttgctaat aagcctgaac cagctgcgcc agcgccagca atgccagcag
     6181 gtatggatcc aggaatgatg ggcggcttct aagctctcta tagcattaag gattatgaaa
     6241 aagaagttga gactaaaggt ctgcttctta ctatgaaaaa agaacaaaga ttggatttcg
     6301 actcatgata tcccatcttt gtttttttag ttgtgatata aaatgctaat ctttgtggtt
     6361 acagactttt aatgtattgg aaaatatatt gtttttcttt gtcatgtgct atcacggagc
     6421 caatgaaaag ttattcccat atatgggtgt tggaggtctg tgatgaatca ttttggagag
     6481 atttttaaaa cctttagaga atcaaaggga tcacgattaa aagatgtcgc aaaggctggt
     6541 atatcaacct ctcagctgtc gcgtttcgaa aaaggggaga cggacttaac catatcgaca
     6601 tttatgctga ttttggatga aagtaacatg cccattgatg agtttatgta tgctgtccat
     6661 gattttcatc gtgacgactt aaatgaactc ttatcaaaaa gtgaggcatt tcgtaacaat
     6721 tcaagatagt gatggcttga agcagttact tcatgctcaa ctagcatcaa ctgataagaa
     6781 ggagatgttc acggatatct ttttggcata tccagcatgt ctaagtctgc tatggcatgc
     6841 cattttggga gtccctcacg cgactctgtc agtagctctc cttcaaagaa agattcacag
     6901 ggctcgactt taccttctgg ctggacccat cctgggaagt tatcgtgttg tctatggagt
     6961 cataaaatca tatcgttatg tttgacacaa atattctccc agtctttaac cgttgctatc
     7021 accagattca ccacctttta gtatagtata agaaaaaagg ggtaaaagag gtttcttgtt
     7081 gcttttttgg cttaaggttt ctttaagtct tatctagtat actaatgtca ttccttaata
     7141 ggataagtat ttggttgtag aagtatcgtc ttaaactaac gctatctcaa ccgattccca
     7201 tcttattcac ccctcctata ccgataaggt ctcacaaagt gtgagacctt attttttgac
     7261 ttcagctcta gttatggaga aacttgttga tacaagcttt tttgggttat ggtattatga
     7321 tctattcaag cctttcttgt ttttgggttt ttctttaacc aacttggctt caatagcttt
     7381 taagcgtttg aaggtttttt cagcgcgatc tagtgaaatc ttatcagctt tttcttgagc
     7441 agctttgggg tcactgacga ctaagtcact gatttctttg gtgctttttt cttgttcggc
     7501 tatccaggtt ttttccaagc ctttcatctc atcaatcact ttagttccaa atggttttgg
     7561 atgagcagcc acgagatcat taatgtgtga caccgtccaa taccatgact tatcgttata
     7621 ttgggtgctt ttttcttgat aggcttcata ggttctactg atattgccaa ggtatggcaa
     7681 gtaaggggca ttacgaggac tgccaataga taaccacatg acaccaccac ccaattcagc
     7741 agggatgtct tttttcagtt ggaaaatatg agcttccatg acattaggat ttgagatggg
     7801 ataagcatag cccttaacag cttttttgga ttttggttta cccttaccgt ctaatgccat
     7861 ctgatcaagt ggtttaagat ccagcccctc aaaacgatta cgttgcagtt tcattgcatc
     7921 ttctagacta aaggtcttat cagtgctttg gagcaactca taattgctgt ctttataagt
     7981 tacttttgaa tcagggtcaa gtgatttaat ccctgagaaa gagcgagagc ggttggcatc
     8041 gtttagtggc ggattgtaag atttggcaat atgaaattta ccatcaactt cggtataaga
     8101 tttggctttt ttagcgactt tttccacatc ttctgaggca atcgtatttt ccttatcgtt
     8161 gaaatcgaca tgtccgagat agaaggtatt tggaaaaaca gcgtatttat catctgggaa
     8221 tttgatggca acatattggt gaccagagag aatttccatg taccagatgc cgtctttgtc
     8281 agccaaggta acaatatttc cttcagcagc tcctttttca gtgactattt tagcaatcaa
     8341 tgcgacacct tcacgggctg ttttgacact tggtaaaatg acactggcca tagatgattc
     8401 cgctaagcca tttttgacgt aaggatcaat tttttggatg gcatcattag ctgaagctga
     8461 tactgttgca gacatagaga cgccaaactc attaaaacca gcttcgtcat aaacgccttt
     8521 attaggtgtt acatcaggaa tcgcactata gcgataagaa tgctcaggca atgggtactc
     8581 aaaaccatta gaggggtctt tccatttttc gccagcagga ttgtcctttg ctagacgtac
     8641 aatgaaattt ttattatggt gtggctcaag atcttctgtt cgaccataaa gaagagaacc
     8701 gtctttggtt aaatctttgc caataataaa accagtacaa gcataactaa cactttgaag
     8761 cgaaaaggct gtcagaatac ttaaaactcc aagtgatatt tttttgttta tcatgcgaat
     8821 cctcctagta aacgataacg ctttcacaga cattataaaa tgctcttttt aaaaattcaa
     8881 gtcttttatg aagtgttttg aaattgttag ctatctaaat attatgagaa ttctctcttg
     8941 aattttggct taacggcccc taaaaacgta taggcagtga actatctagg tttcttcgaa
     9001 aatccattag ccatttatga tataatagta aagaaaaaca tagaaagttg gggtctgttg
     9061 atgaccaaac catttcatca taagaaacta aaacaaataa ctataatagc tgcaactagc
     9121 ctttttttat tcctgattgg tggtgccttt tactactcta aaaatcattg tattaatgcc
     9181 tatcttaaag ctcgatcagc ccaatcagga ccagtttttg agaatatcaa agcatatcta
     9241 gtctgggatg atactaatga gcagatcaca aatgacgagg cgatgtatac taagtttaga
     9301 aggtatagtc aaaaagaatt gaggcaaaaa aagcaggatt taaaagccgc tagtcaagat
     9361 agtgccgttc aagtaaagtc tgttggtcgt cgtttttgga tttttcctga ttatcggatt
     9421 gccataaaac ccatggattt aacgataaaa acgaatgtgc ctcaagcaga cgttctttta
     9481 aatcaaaaaa aagttgctgt ttctgattca gaacagttct cagtcaagct tgatcggcta
     9541 ccaacggcag aatataccgc aagtatcaga ggcaaacaca acgggcgaaa cattaaagtc
     9601 aataaatcat atgatggtga taatcccgtg ctagatttga gtgtgtcttt tagaactttt
     9661 ttggtaacaa gcaatgctaa gcaaggagat ctttacttcg atgataacca tattggcaca
     9721 ttaaaagatg gtcaattaca agtagaagat taccctgtta cagaaaacgc acaagcttat
     9781 atgaaaacaa cattcccaga tggtgagtta agatcacaaa aatatgctct agctgatgtt
     9841 gaagaaggag caaccctgga gattttagtt acagatcttt tagaagagga catagcaggg
     9901 gagctattag tatcagcttt tgatcagctg atgcactacc tcagtacagg tcaagactca
     9961 tctaacttac gtagcgtctt tgaggcaggg tctagcaacg cattttatag gggattgaaa
    10021 gagtccataa aagcgaaatt tcagacagat acaagaaaag ccagccgtct caatattcca
    10081 tctatccttt tgacaacaat gactcaagtg ggcaaaacaa cttacgtgct tgatttcaca
    10141 gctacctacg aatttttgta tgacaactca acagatcctg agcagcatac ctctggacat
    10201 attaatcaag acttgactgg aaaagtgact gtaaaaaaag ttggacagca ttaccttatc
    10261 agccagtccg gctctaaaaa tattactgtt gttaaagagg acaatcaact caaagcgcca
    10321 tctgtctttc ctgagtctat tttgggaacg tggacaggcc aagccaatgg tttaagcatc
    10381 catatgtctc tagcatcaga tggaacaatt acgactaaag ttgaagatca aaaaggcaac
    10441 cgttctaaag aaactcggac agctaaaatt agtaaagttg aagacaaagg caatggtttt
    10501 tatctttata cgccagatcc tggaagtgac ataagcgcct tagctccaga aggaggattg
    10561 gggggtgcaa atgtcaaata tgcttatggt ttcaaaatat ctggtaaaac agcctctcca
    10621 gtggtgtggc aggcagcatt aacacatgaa tttgattata ccaagccact ttcgggagta
    10681 actttgcaaa agcaaccata aaggatgcaa agccacaaag aacagtagaa acaatgttat
    10741 tactcaaata cagtgctatg aaaacagcta aactcaaaag gctaggagat tatttcctag
    10801 ccttttgagc gtttaagact gcgtcaaatg tagctgattt agcttgcacg caaatgtctt
    10861 cttgggttag agggtgtttc aaacgtaatt gataagcatg gagcatcagt cgagcacaat
    10921 ctttttttcc attagaatac aaaggatcac caaataaaac atgaccttga tgggctaaat
    10981 ggactcgaat ttgatgagtc cgtccagttt gtaattgaca attgagtaag cttgccgttt
    11041 tgtggaagtt tttgactaga gttacctcag taatagcttt cttgccattt atcggatcga
    11101 caacacgttt tctgcggtca tgtcgatgac gaccaattgg atgatggtaa gttaccctag
    11161 gactgtctaa ggatccgtga actagtgcca aatattctcg atggatgtct cgtttttcta
    11221 aaagacgatt aaggattggt aagataaaag gtgttttagc aaataaaatg gccccacttg
    11281 tttccttatc cagacgatga accacatagc aggtctgtcc cgtgtaagca gacacgtggt
    11341 tgagcagcgc caactctgtt ggatcattgc cgtgtgtttt catcccttca ggtttgttaa
    11401 caataatgat gtgctcatct tcataaaggc aggttacttt ttcggcctgc cccatcacga
    11461 taatcttttc aggataatct tcgtgatcga aaaaaagttt gacctgatca ccgtatttaa
    11521 cacaactttg ccagttaaca ggatgaccat taataagaac atgtttttta gttctcagaa
    11581 aatgcctaat tttacgggga attaacaatt gttcctctaa taatgctttg actgtcaatt
    11641 cttcaaaggg atttttcagt gtgacagtaa acccctttga tggtttattt gttgtcttca
    11701 ttgagccagt tatggtattt ttcaacaagg ttgatagcca tttgggtggc aagagcagca
    11761 gagaaagctt cagtaccttc acgctcgtca ttagctacct ccaagcgagt ctcatcgtaa
    11821 atggctttta gactttctgc ggataaggtt tctttaaaag cttggaattt attcattggt
    11881 taaacccgtc cttctatgtt taatgtgagc tcctgattaa tgcaaggaat tcaatgctat
    11941 tatagcatgt ttctaatcaa aacgtgccac tcaaaaaggt aaaaacgtta ttttgctaat
    12001 ccatctaata agaaagtgtc ttaaataaga cctcttgata gagtttgtaa caaaaatgat
    12061 atgaaactag gtgctaacgc agaaatagaa accaactaac gtgttgcgaa gttggaacag
    12121 tcataaaaaa tagcaagata aaacttatca acacacagtt acctaagacg atgagtcaaa
    12181 caggtatgtt ctttcaaaac aaccccatga ggttgaacga cgtatcggaa aaatacggat
    12241 tagtttggcc ttatgatagg tatttctcta tcgtaaaaga agtcaaccaa aggtttttaa
    12301 tataaaatat taagaaaaat tgttataatt atgataaaaa cataatcgta aaatagagga
    12361 aaaacaatga aaacaattag acgttatgat gttaacgaag atagagggca tacaggcctt
    12421 gtagaagcag gagacttcta ttatttaaac tattgtgtcg gcaatgtcgg acaagacatt
    12481 gaaagtcaga ttaatggagc ctttgacgag atggagcgcc gattagcatt ggtggggctc
    12541 acattagatg cagttgttca aatggattgt ctatttcgag acgtttggaa catacctgtg
    12601 atggaaaaaa tgattaaaga gcgctttaat ggcagatatc ctgctcgaaa atcgattcaa
    12661 acggaatttg cacatcacgg tggaccacaa ggactactct ttcaagtgga tggtgtggct
    12721 tattcaaaac atatttcgat gacctaatca aggttacttt aagatcatag tggtataata
    12781 acgttatgag atttctagaa cttttacaaa agaaattttt tcctaaagca tatcaggaaa
    12841 aacaattctt aatgcatcaa aaaacgcgtt taacgccaca acacaatcaa aagcagtatt
    12901 cgccaaatgc caatcatttg gactcatcag ctaccaaaaa ctcagaacaa gaccctgcaa
    12961 tagctctgca acgcagtaga gcctatgaag gaagccctaa aagtcggccc gcttggttgc
    13021 aaaagctgga agctgttttg ccgtctcctc aacatccaat tcggcgtttt tggcgccgct
    13081 atcacatcgg aaaactgcta atgattctga ttggaactct tgtcttactc ttaggatcat
    13141 acttgtttta cttatcaaaa acagctaaag tatctgattt acaagatgcc ttgaaggcta
    13201 caactgttat ttatgatcac aaaggagagt atgcaggcag tttatctggt caaaaaggga
    13261 gttatgttga gctcaacgct atttcagatg atcttgagaa tgctgttatt gccactgagg
    13321 ataggacttt ttacagtaat agcggtatta atcttaaacg cttcttattg gcagtagtta
    13381 cggcgggccg ctttggaggt ggctcaacga ttacacagca actggctaaa aatgcttatc
    13441 tctcacaaga tcagacaatt aaacgaaagg ccagagagtt ttttttggcg ttagagttga
    13501 ccaaaaaata cagtaaaaaa gatattctta ctatgtacct taacaactcc tattttggaa
    13561 atggagtttg gggagttgaa gatgccagtc aaaaatattt tggaaccaca gctgctaact
    13621 taacattgga tgaagctgcc acattagcag gtatgctcaa aggacctgaa atatataacc
    13681 cttaccattc tctaaaaaat gctactcacc gtagagatac tgttttagga gcgatggttg
    13741 atgccaaaaa gattacccaa acaaaagctc aacaagctag agcagtaggg ctaaaaaatc
    13801 gcttagctga tacttatgtt ggtaagacag atgactacaa atacccatcc tactttgatg
    13861 ctgttattag tgaagcaata gcaacttatg gtctttcaga aaaagacatt gttaataatg
    13921 gatacaaagt ttacaccgag ctagatcaaa attaccaaac tggcatgcag acgactttta
    13981 acaacgatga actatttcct gtttcagctt atgacggtag ctctgctcaa gcagctagtg
    14041 ttgctttaga tcctaaaaca ggaggtgtta gaggtctgat tggtcgtgtg aatagtagtg
    14101 aaaatccgac tttcagaagt tttaactatg cgactcaagc aaaacgtagt cccgcatcaa
    14161 caatcaaacc actcgtggtt tacgcgccag ccgttgcttc aggatggtca attgaaaaag
    14221 aactaccaaa taccgttcaa gatttcgatg gctatcagcc acataattat ggaaattatg
    14281 aatcagaaga tgttcctatg tatcaagcat tagcaaactc ttataatatt ccagcagttt
    14341 ctacattgaa cgatatcgga atcgataaag cctttaccta tggtaaaaca tttgggttag
    14401 atatgagctc tgccaaaaaa gagttggggg tagctttagg tggcagcgtg acaaccaatc
    14461 cattggagat ggctcaggca tatgctgcct ttgccaataa tggagtaatc catcctgcgc
    14521 acttgattaa ccggattgaa aatgccaggg gtgaagtgct taaaaccttt actgataagg
    14581 ctaaacgtgt tgtcagccag tctgttgcag ataagatgac agccatgatg ctaggtacct
    14641 tttcaaatgg aacagcagtc aatgctaacg tatatggcta tacactagct ggtaaaacag
    14701 ggacgacaga aaccaacttc aatcccgact tagcaggcga tcagtgggtt attggttata
    14761 cgccagatgt tgttattagt caatgggtag gatttaatca gaccgatgaa aatcattatc
    14821 taacggattc aagtgcaggc acggcttcag ctatttttag cactcaggca tcttacattt
    14881 tgccttatac caagggcagc caatttcatg tagataatgc ctacgctcaa aatggtattt
    14941 cagctgttta tggagtcaat gaaacaggta atcaatcagg agttgacact caatctatta
    15001 ttgatagttt aagaaaatca gcacaagaag cttcgcaatc actatcaaaa gcagtcgatc
    15061 agtcagggtt acgtgataag gcccaatcta tttggaaaga gattgttgac tattttagat
    15121 agcttgcagt attttagaga tcgtgttaaa ataatagtta cggaggcgtt atggcacaga
    15181 aaaaagcgag tctagcgtgt gtcgaatgtg gcagtcgtaa ctactctatc ggagtgagta
    15241 gcacgccaaa accaacacgt ctagaagtaa ataaattttg caaatactgc aaaacatata
    15301 ccttacacaa agaaacacgt taaaaaggag agcctgatgg gattcattag cgggactttt
    15361 aaagtcttaa aagacacaac atggccaaat cgtaaacaac gttggaaaga ttttatctca
    15421 gttcttgagt acacagcttt ctttacggtg attatctaca tctttgacca gctcttagca
    15481 aagagtgtat tagcactgat taatttattc taggtcaaga ttggtagaaa tgataagctt
    15541 gcttggaaaa gcctaggctg ggagtattcc cagccttttt tgtagtatca ataatctgat
    15601 tagtaagctt ttttaaagcc catactggtt tgagctttaa aaaagcataa aggtaaaggc
    15661 aatgtagcaa cgatctccaa accaagtgca ctaaattagc ttgtaacaga gtcaacgcat
    15721 aaacagcctg gcctcacttg cttagcacat taaaaatagc aatgaatatt atggttgagg
    15781 aaaacagcct gatagtctgc taaatcttcg ggatgataag ccttgacctc agccatctca
    15841 tactccctac ctagaagttt gtacttgttt tctccaaatt gatggaaagg taacagttgc
    15901 acttggtcaa tctcaagctg attaaagagc tctgagaagg ctttagcatc gtctagggaa
    15961 tcattaaatt ggggaataac agggatgcgc aagacgattt cttttccagc ttgaaaggca
    16021 taatgaatat ttttgataat caagtcatta cgaaccccag tcactttttg gtgtctgagc
    16081 tgattataat gtttcaaatc ggtatagata aagtccacgt agtcaataag ggtgacaaat
    16141 tgctcgtgtt tggcaaaggc ggtggtttca attgcggtgt gaagacctgc tgctttggct
    16201 gcttttaaca gggctaaggc aaagtcaaac tgagcaaaga tttccccccc tgacagggtc
    16261 atgcccccac ctgactcttc gtagaaatca aggtctttaa ggacttcttc gatcacctcg
    16321 tccacggttt tttcctctcc aactatttta gtattaagcc catcacttgt taacatctgc
    16381 tcaggcgctt tttgttggga ttcgggattg gcacaccatg gacatctcaa ggggcaacct
    16441 tttaaaaaaa cggttgtccg aataccagga ccgtcatgaa tactaaaatg ttggatgttg
    16501 aaaacaatac cgcgatcagt cataagtgtg aattcctttc gttgtaaaac catcatacca
    16561 gataaacgta aataaatcaa ttacgaatga aagtaaatat cccttttctt ttaagaaaat
    16621 aactggtaca atgaaaggga ggtgaatgat gaatcgatta gaacgtatta ttcaactggt
    16681 ttcccagaag aaaaaaatag atgttaacag tttatcagag caattagacg tttcgaaagt
    16741 aaccattcga aaagaccttg ataagcttga aagtaagggc ttgttgcgac gggaacatgg
    16801 ctatgcggtg ctaaacagtg gcgatgacct caatgtacgc ttgtcctaca attacaacat
    16861 taagcgacgg attgcagaaa aagcagctga attggtgcaa gacaacgata ccattatgat
    16921 tgaatctggc tcaacctgtg cccttttggc agaagtactt tgccagacca aacgaaatat
    16981 taaaatcatt accaattcgt gcttcattgc caactacatt cgtcaatata gtagctgtca
    17041 aatcatttta ctgggcggtt attaccagcc caattcagag gtgactgttg gtcctttatt
    17101 aaaagaaatg atatcccttt ttcatgtcaa tcgtgtcttt gttggaacag acggtttcaa
    17161 caaagatctt ggctttatgg gcaaggacat gatgcgctca gaaggggtgc gttacatggc
    17221 agatgctgct gaggaagtgg tgattctgac cgattccagc aagttttcaa aaaccagtct
    17281 ggtacaccag ttgtcattag ctgatgtcaa tcgcgtcatt acagaccaag cactagacaa
    17341 gcaaacacaa gagttattaa gtgctagtgg tcttgttctt gattttgttt cttagaaaat
    17401 aggtggctag atgaaagaag aacgcagacg gctccttgcc aaggtggctt acttgcatta
    17461 tgttcaaggc aagagccaaa ccttgatttc aaaggaaatg aatatctacc gaacaacggt
    17521 ttgtcggatg ttagcaaaag ccaaggaaga aggcattgtt cggattgaaa ttgccgacta
    17581 tgatgctgat ttatttgctt tagaagaata cgtgcgaaag cagtatggct tggaaaaact
    17641 agaccttgtg cccaaccagg ttgaagatac cccaatggat accttgacaa atgttgctaa
    17701 aacagcagct gaggttttta gacatgttgt taaagatggc gataagatcg gtctgtcctg
    17761 gggagcgact ctttcttgct tgatggatga gttaaatcca aaagcgatga aagatgtgtt
    17821 tatttatcct ttggcaggag gacctagcca tattaatgcc aaataccatg tcaataccct
    17881 ggtttaccgc ttggctcgca tctttcatgg taatagcgct tttatgaacg ctatggtcat
    17941 tcaagaagac aaacacttgg ctaagggaat cttacaatct aaatacttta acgacatttt
    18001 aacaagctgg gaccagctag atcttgcctt agtaggaatt ggtggggagc ctaatagcct
    18061 tgagcagagc caatggcgtg atttattaac cagctcagat catgaccaac tcaaatatga
    18121 aaaagccgtt ggtgaagttt gttgtcgttt ctttgatcag gcaggtcagc cagtttacac
    18181 tggcctacag gatcgaacta ttggtatttc gctagaacag ttgaggcgtg tccccaaaac
    18241 aatggctgtt gcaacaggta aacacaaggc taaggcaata ttggcagcct taaaagcagg
    18301 ttttatcaat tatctagtga cggataaaga gaccatgcta gctgttttag cgttagatga
    18361 agatattgat cttaataacg ttcttcttta atagaaattc aaagatacta tgatatttat
    18421 aaaggcccaa gaccaaacgt cagggctttt tttgtttgat gtgttgatga aacagagatt
    18481 gctcaaatgt gcagttaata tattggcaca aaagtgcatt aaccaaaata tagcacaaaa
    18541 tatattgacc ctaaaaacaa aaatgataca ataaacttac caacgaaatg taaacgatta
    18601 caaacacaat aacatcacct tcgaaaaaaa gactcattgc cgttacatca cataaaaaag
    18661 aaaaaaagga gacaccaatg caagttattg taccagacca aatcattatg ggcttaattt
    18721 taaatgcagg cgatgccaaa caacatatct accaagctct gaaatgtgct aaagaggacg
    18781 attatgccac tagtgaaaaa gagatggcct tagcagatga tgccttatta gaagcccaca
    18841 atttacagac ccagtttctt gcccaagaag ctagtggtaa taagtcagag attacagctc
    18901 tttttgttca ctcacaagat cacttgatga cgaccattac agaaattaat ctcatcaagg
    18961 agattattga ccttcgtaaa gaattggcaa ccaaataata tttcattcat aaaaaggaga
    19021 ttgacatgat taagattgga ttgttttgcg cagcagggtt ctcaacaggc atgttggtga
    19081 ataatatgaa agtagctgct gaaaagaaag gcattgactg ccagattgat gcttattccc
    19141 aaggaaagtt ggctgagtat gctccattga ttgatgtggc acttttaggc ccacaggttg
    19201 cttacactct ggataaatca gaaactatct gtaaagagaa tggcatcccg attgcagtta
    19261 tcccaatggc tgattatgga atgttagacg gtaacaaggt gcttgattta gcccttagcc
    19321 ttgttaaaga ataggagtca atcatggcaa aaatgaatat gcaaaacatc atcatgccaa
    19381 tcatgaaatt tgtgaatatg cgcggcatca ttgccttaaa agatggtatg ttagccattt
    19441 tacctttgac tgttgtgggg agtcttttcc tgattgctgg gcagattcct ttccaagggg
    19501 ttaatgatgc tattgctagt gtgtttggtg ctgactggac agaacccttt atgcaggttt
    19561 accatggaac atttgctatt atggggttga tttcctgttt tgcaattggc tattcttatg
    19621 ctaaaaactc aggtgttgaa cctctccctt caggggttct atccttgtca gccttcttta
    19681 ttttattgag atcatcttat gttccagcag aaggcgaacc tatcggtgat gctattagca
    19741 aggcttggtt tggtgggcaa gggattattg gtgctattgt gattggttta acggtaggtg
    19801 ctatttatac agcatttatc cgtcgccaca ttgtcatcaa aatgccagag caagtgccac
    19861 aagccattgc caaacagttt gaagctatga ttccagcctt tgtgattttt accttgtcaa
    19921 tgcttgtgta cattattgcc aagtcagtga caggtggtgg cacctttatt gaaatgattt
    19981 atgatgtcat tcaggtaccg ctgcaagggt taacgggttc tctttatggc gcactaggta
    20041 ttgccttctt tatttccttt ctttggtggt ttggcgtgca tgggcaatct gtggtcaatg
    20101 gaattgtcac tgctcttctc ttatcaaatt tagatgccaa taaggccttg atggcagcag
    20161 gtgagttatc cctagacaag ggtgcccata ttgtaaccca acaattttta gactctttct
    20221 tgattctatc aggttctggc attacctttg gtttagtggt agctatgatc tttgcggcta
    20281 aatccaaaca atacaaggct ttaggtaagg ttgcagcctt cccagccctc tttaatgtta
    20341 atgaacctgt cgtctttggt tttccaattg tgatgaatcc agtcatgttc ttgccattta
    20401 tcttggttcc tgtattggca gctctcacag tttatggcgc cattgctatt ggtttcatgc
    20461 agccctttgc aggagtgacc cttccgtggt caacaccagc cattatctca gggttcatgg
    20521 ttggtggctg gcaaggagct attgtgcaaa ttcttatact catcatgtca acgttggtgt
    20581 acttcccatt ctttaaaatt caagataata tggcttatca aaatgaacaa gctagtgaag
    20641 agtcatgatt tagcgtccac acaaattctt gagaccatct ccagttagag gtggtttttt
    20701 agaaaaagaa gagcgactta tcaggcctat attgcacaat agtgcaaaat aaagtgacta
    20761 tctcttctta tggttaagga tacgcaaaag tcgcaatata tgataaaata gttacgaaag
    20821 aaacatttat aatttcgtaa gaaagaagga gaccccgcat gactgaaaca aaaagccctt
    20881 attttggaca tttaacagac agaatgactc actatcgtga agctgtgtta gacaagaaac
    20941 cttatattga tgctgagcgt gctattttag ccactgaagc ctatcaaaaa caccaaaata
    21001 agccagcaaa cctcaaacgc gcttacatgc ttcaaactat tttggaaaac atgaccatct
    21061 atattgagga tgaaagcctc attgctggta accaagcctc ttcaaacaag gatgcaccga
    21121 ttttcccaga atacactctg gaatttgtcc tcaacgaact tgatcttttt gaaaaacgag
    21181 atggggatgt cttctacatt accgaagaaa ccaagcaaca gctccgagac attgccccat
    21241 tctgggaaaa caataactta cgtgctcgct gcggggtctt gctaccagaa gaagtgcaag
    21301 tgtacatgga aacaggtttc tttggcatgg aaggcaagat gaactctggg gatgcccatt
    21361 tagcggttaa ttaccaaaaa ctcttggagc acggcttaaa gggatttgaa gaacgggcac
    21421 gagctgccaa agctgcgctt gatttgacca ttcctgaaaa cattgacaaa taccattttt
    21481 acgactctgt ttttattgtc attgatgcag tcaaaactta tgccaaacgc tatgccaagt
    21541 tggctagaga actagcaaaa acggctaaac cagaacgtca agcagaattg ttagacatcg
    21601 cgcgtatttg tgacaaagtg ccttacgaac cagcgaaaac ctttgcagaa gctgtgcaat
    21661 ctgtctggtt cattcagtgt atcttgcaaa ttgaatcaaa cgggcattcc ctatcttatg
    21721 gccgctttga ccagtacatg tatccttatg tcaaagctga tttggaggct ggccgtgaaa
    21781 cagaagactc aatcgttgaa cgtttgacta acctctggat taagaccttg accattaaca
    21841 aagtgcggag ccaagcccac accttctcat cagcaggtag tccactttac caaaacgtga
    21901 cgatcggtgg tcaaacacgc gataaaaaag atgcggtcaa cccactgtct taccttgtcc
    21961 tacggagtgt ggctcaaacc aaattgccac aacctaactt gactgttcgt taccacaaag
    22021 gcctagacaa tacctttatg aacgagtgta tcgaggtcat gaaacttggt tttggcatgc
    22081 cagccatgaa caacgatgaa atcatcattc catctttcat caaaaaagat gtctcagaag
    22141 aagatgctta tgattactca gccattggct gtgtggaaac agcggttcca ggcaaatggg
    22201 gctaccgttg cacggggatg agttacatca acttccctaa aatcttgctg attaccatga
    22261 atgacgggat tgacccagca tcaggcaagc gctttgcaaa aggatacggt cacttcaaag
    22321 acatgacctc ttatgaagaa ttaaaagcag catgggatgc caccttgcgc gaaattaccc
    22381 gcatgagcgt cattgttgaa aatgccattg acctaggtct tgaacgtgaa gtgccagata
    22441 ttctttgctc agccttgaca gatgattgta tcggtcgtgg caagacctta aaagaaggcg
    22501 gagctgttta cgactatatc tcaggccttc aagttggaat tgccaaccta tcagactccc
    22561 tagcagcgct gaaaaaatta gtgtttgaag aaggccgctt gaccccagaa gaactctggc
    22621 agtcccttga aagtgacttt gctggagaac gcggagaaga aatccgccaa atgctcatca
    22681 atgacgcacc aaaatatggt aacgatgatg actacgcaga tagtttagtt gtcgaagctt
    22741 acgacaccta cattgatgaa attgccaaat acccaaatac ccggtatggc cgtggcccaa
    22801 tcggaggtat ccgctattct gggacatcat caatctcagc caatgtcgga caaggaaaag
    22861 gaaccttagc gacaccagac ggtcgccatg cagggacacc cctagcagaa ggctgttcac
    22921 cagaacacag catggacaaa aaaggaccta cttcagtatt gaaatctgtt gctaaattac
    22981 caacagatga gattgtcgga ggagtactac tcaaccaaaa agttaaccca caaaccctgg
    23041 ccaaagaaga agacaaactg aaattaatgg ccttacttcg taccttcttt aatcgcctac
    23101 acggttatca tatccagtac aatgtcgtgt cacgtgaaac cttgattgat gcccaaaaac
    23161 atcctgaaaa gcaccgcgac ctcattgtcc gtgttgccgg ctactcagct ttcttcaatg
    23221 tgctctcaaa agcaacccaa gatgacatta ttgaacgtac agaacacaca ctttaggaga
    23281 aaataagtat ggaatacatg ttagacactt tagatttaga agctattaaa aaatggcatc
    23341 acattttgcc tctcgcaggt gtgacctcaa acccttctat tgccaaaaaa gaaggtgaca
    23401 ttgatttctt tgaacggatt cgagaagtcc gtgctattat tggtgacaag gcttctattc
    23461 atgttcaagt gatcgcccaa gattacgaag gcatcttaaa agatgctgct gaaatccgca
    23521 ggcaatgtgg agatagtgtg tatgtcaaag tacctgtaac cacagaaggc cttgcagcca
    23581 ttaaaacctt gaaagccgaa ggctatcata tcacagcaac cgctatttat acgaccttcc
    23641 aaggcctatt agccattgaa gctggtgctg attatttggc tccttactat aaccgtatgg
    23701 aaaatctcaa tattgatcca gaagctgtca taggacaatt agcagaagct attaaccgcg
    23761 agaatgctga tagtaagatt ttggcagcaa gctttaaaaa tgtggctcag gttaataaat
    23821 cctttgctct aggagcacaa gccatcactg ctggcccaga tgtgtttgaa gcaggatttg
    23881 ccatgccatc tattcaaaaa gcggttgacg attttggcaa ggattgggaa gccattcatc
    23941 accgcaagag catttaagaa atagcatcag tagtaatcac atcattagga atcacagata
    24001 aaggagttca acgatgaaag tatttgcaag tccatctcgt tacattcaag gtaaaaatgc
    24061 cttgtttacc aatgctaaaa ccctaaaaca actaggggat agccccattt tactgtgtga
    24121 tgacgtggtg tatggcatcg tcggagaaag atttgaaagc tatttgatag ataatggcat
    24181 gactcctgtt cacgtagcct ttaatggcga agcctcagat aatgaaatca gtcgcgtggt
    24241 tgccattgcc aaggaaaatg gcaatgatgt tattattgga cttggtggtg gaaaaaccat
    24301 tgacagtgct aaggctatcg ctgacttact tgctgttccg gtgattattg ccccaaccat
    24361 tgcttcaaca gatgccccaa cctcagcctt atcggttatt tacaccgatg aaggagcctt
    24421 tgaaaaatac attttctatt caaaaaatcc agatcttgtt ttggttgaca cacaagtgat
    24481 ctgtcaggca ccaaaacgat tactggcctc tgggattgca gatggattag caacatgggt
    24541 agaggcgcgt gctgttatgc aaaaaaatgg agacaccatg gcaggtggca atcaaacctt
    24601 ggcaggagtt gccattgcca aagcctgtga gcagaccttg tttgcagatg gcctaaaagc
    24661 gatggctagc tgtgacagac aagtcgtgac cccagccttg gaaaatgtca ttgaagccaa
    24721 tacactcctt agcgggcttg gttttgaaag tgcgggtctg gctgctgcac atgccattca
    24781 caatggcttt acagcgctga caggtgctat tcatcacctt acccatggtg aaaaagtcgc
    24841 ctatggcacg ttgacccaac tcttcttgga aaatcgttcg cgtgaagaaa ttgaccgcta
    24901 catcgacttt taccaagcta ttggcatgcc aacaaccctc aaagaaatgc atttagacac
    24961 ggctactcaa gaggatttct taaaaattgg ccgtcaagca accatggcag gcgaaaccat
    25021 ccatcaaatg ccatttgtta tcagtccaga agatgtagca gcggctttgg ttgctgttga
    25081 tgcctatgtt acgagtcgat aggctaacca aaaagagatt tcttatttgc cagataacct
    25141 caaaaaaaca agtctaggga gtcacttcct agacttgttt tgcttactgt tggttggtaa
    25201 tagcactttt agcggggtca ttgtgggcaa tacgactggc agctgcagca gcaatggcgc
    25261 taacaatatc atctaaaaag gtatggcagg agttaccatc tttatggttg agtttgtcaa
    25321 caattcctgg ttttgtcttg tccagatacc cataattggt aaaaccgata gacccataga
    25381 ggttaacaat ggataaggcc aggatttcat caatcccata cagcccttgg tcggttttca
    25441 agatactaag gagtggctca gacagctggt tggcttcagc caatttatcc aattctaccc
    25501 cagtgataat agcgttttgc acttctcgtt ttgcaagcac cgcctcaacg ctctctaaac
    25561 attctgccat ggtcaaattg ggaatataat cattctgcaa aaaaagcacc agctctgcaa
    25621 tagcttctaa agaaccccct cgctcagcca gtaattgata agacacttct cgtaggtgat
    25681 ggtcagttga catgtgagac ctcctttttt tctttattgt aacataaaag atttcgagaa
    25741 acctctacaa cagctaaaga ggggatagtt cttttttaag agatgttgac tactgagatc
    25801 ccctacttgg taaaagtcaa agaaacgata gtaaagtaac catcttacct aggcctaaat
    25861 acaatcacca cccctaggtg acacacagca cctatttcaa aaatgatatt agtatggcaa
    25921 aacaaaaaga caacgccttc ttttttctcc ttactatctc ctttaatttt catatttttt
    25981 aaaaaaacta ttgataaact agttaagtaa gcgtatacta tggttagtga gcgaaattag
    26041 aaaagaggac aagcatatga atctacttgg atcaagacgg gttttttcta aaaaatgtcg
    26101 gctagtaaaa ttttcaatgg tagctcttgt atcagccaca atggctgtaa caacagtcac
    26161 acttgaaaat actgcactgg cacgacaaac acaggtctca aatgatgttg ttctaaatga
    26221 tggcgcaagc aagtacctaa acgaagcatt agcttggaca ttcaatgaca gtcccaacta
    26281 ttacaaaacc ttaggtacta gtcagatcac tccagcactc tttcctaaag caggagatat
    26341 tctctatagc aaattagatg agttaggaag gacgcgtact gctagaggta cattgactta
    26401 tgccaatgtt gaaggtagct acggtgttag acaatctttc ggtaaaaatc aaaaccccgc
    26461 aggctggact ggaaacccta atcatgtcaa atataaaatt gaatggttaa atggtctgtc
    26521 ttatgtcgga gatttctgga atagaagtca tctcattgca gatagtatcg gtggagatgc
    26581 actcagagtc aatgccgtta caggaacacg tacccaaaat gtaggaggtc gtgaccaaaa
    26641 aggcggcatg cgctataccg aacaaagagc tcaagaatgg ttagaagcaa atcgtgatgg
    26701 ctatctttat tatgaagccg ctccaatcta caacgcagac gagttgattc caagagctgt
    26761 cgtggtatca atgcaatctt ctgataatac catcaacgag aaagtattag tttacaacac
    26821 agctaatggc tacaccatta actaccataa cggtacacct actcagaaat aataccaaaa
    26881 ggctagacct ctgctcacta ggcctagctt tttacatcaa aaaaagcaat gactatagaa
    26941 agtaaaaata ctagaaaaag caatgattgc cgtcattgct ttttatgatt tgtcaaaaag
    27001 taaaaagcaa attgaaaaaa tcgccctgga gctgttgaga taaactacac catttattaa
    27061 gataccaaat caaaaagcta acaccataag agcgttagct ttttaaagag cctcaggaca
    27121 gtttatgttt aatggcttct aggtaggttt gaaacatatg atggatcgtt ttgcaattaa
    27181 gtaattggaa gatctccaag atctgcacac acttttgctc agccccctct ttaccattta
    27241 tgaggccaat aatgccatca aaaaaagaca cacaacaccg ttcatataag caatcatcat
    27301 ttagctgata atcttcaatt tttgccaaaa tctcagaagc tttatcatac tcttgtcgct
    27361 gaataaacaa aatcaacata ttgacaaaca tccgaatcga ttcattccca taatacctta
    27421 gggtattgta tttatcgagg ttcaaaataa cttttgaaaa caccatctca ataaagcaag
    27481 actcaaaaat aaacatacaa ttattaaaaa gcacagtctc atagtgactc caagtttcaa
    27541 tattaataag atagtttgac aaataagtcc gctctgtcag acagtcttcc tcagtaagag
    27601 ttgctaataa caccttgacc aaggcaaaaa ggttcttttc ctttattgac ttactatctt
    27661 tataagaatc aaggatatga tttaaacctt ctatgtttcg gcattcaaaa taatgctttg
    27721 ccgtatccat atcaataaat tctttgtatt gtttaaagtt attactaata aagagaaact
    27781 catcaacatt gacattcaag ttgtctaaga tataaagtaa ctttttcgaa gaaatgtcaa
    27841 gattattttt aataaaacga taataggttt gcctagtgag ataatcacca caaacttgtt
    27901 taatcgaaat gttttttgaa tgcctaatga attcaacggt ttcaccaatt tccatatgtc
    27961 aagccttcct agttgatgtc aaaaatacgt tacgcatgta cctaatacgt aacaagttga
    28021 atgtttcgga tgatagtcgc ttatgatagg tgcataaggt caatagccag atgcgatagt
    28081 tttatcaact gtcatatgtt aaacctttct aatctaatag atgttaaaaa tacgttacgt
    28141 gtgtacctaa tacgtaacaa aataatgggt tagcaaaata agcagctatg atatagccat
    28201 aaggttaaaa ggaggcgcct actatgtggt tattgttact atttttgtag ttccttttgc
    28261 aaaatggtag tagataaaaa tgagaagtca ataaaagcat tgacaaacaa aagaatcatt
    28321 ttgtttatat tatcagtatt tttaagtttc ttgtcaactg aaatgagcat ctactagcca
    28381 caatagtaac taaaaggcta attgtcagta aaaatgagat aaatcagcca ggaaaaagcc
    28441 tacgagtcaa ctaatggaca acccaaaaaa agacaaagga ctttcacttg gtgttgtgga
    28501 ccctatcacg atccttatca cagaatcagt tattaacaaa atgagaacgg tcccatatca
    28561 tctaaaaaaa ctgtcaagca caacctattg tttgctagct gatcttgcct atcagtctgc
    28621 ctagtagata cggcagaaga taagagatca accaaaagat gataagtgca acgactcata
    28681 gcgtcttttg accaaaacca attaggctca catgagatga gaataattgg gttgggttgt
    28741 cagtgtcaac taaccgtgtt attgtctatt accattcatg gtatcagcga catcgtatga
    28801 taaccatacg attcagctaa gtaaggaggt gtgtccaatg taccgttaaa agcaaatgca
    28861 gtagattaac ttattttgaa agaggtataa aaaaaatgaa taaaaagaaa ttaggtatca
    28921 gattattaag tcttttagca ttaggtggat ttgttcttgc taacccagta tttgccgatc
    28981 aaaactttgc tcgtaacgaa aaagaagcaa aagatagcgc tatcacattt atccaaaaat
    29041 cagcagctat caaagcaggt gcacgaagcg cagaagatat taagcttgac aaagttaact
    29101 taggtggaga actttctggc tctaatatgt atgtttacaa tatttctact ggaggatttg
    29161 ttatcgtttc aggagataaa cgttctccag aaattctagg atactctacc agcggatcat
    29221 ttgacgctaa cggtaaagaa aacattgctt ccttcatgga aagttatgtc gaacaaatca
    29281 aagaaaacaa aaaattagac actacttatg ctggtaccgc tgagattaaa caaccagttg
    29341 ttaaatctct ccttgattca aaaggcattc attacaatca aggtaaccct tacaacctat
    29401 tgacacctgt tattgaaaaa gtaaaaccag gtgaacaatc ttttgtaggt caacatgcag
    29461 ctacaggatg tgttgctact gcaactgctc aaattatgaa atatcataat taccctaaca
    29521 aagggttgaa agactacact tacacactaa gctcaaataa cccatatttc aaccatccta
    29581 agaacttgtt tgcagctatc tctactagac aatacaactg gaacaacatc ctacctactt
    29641 atagcggaag agaatctaac gttcaaaaaa tggcgatttc agaattgatg gctgatgttg
    29701 gtatttcagt agacatggat tatggtccat ctagtggttc tgcaggtagc tctcgtgttc
    29761 aaagagcctt gaaagaaaac tttggctaca accaatctgt tcaccaaatt aaccgtagcg
    29821 actttagcaa acaagattgg gaagcacaaa ttgacaaaga attatctcaa aaccaaccag
    29881 tatactacca aggtgtcggt aaagtaggcg gacatgcctt tgttatcgat ggtgctgacg
    29941 gacgtaactt ctaccatgtt aactggggtt ggggtggagt ctctgacggc ttcttccgtc
    30001 ttgacgcact aaacccttca gctcttggta ctggtggcgg cgcaggcggc ttcaacggtt
    30061 accaaagtgc tgttgtaggc atcaaacctt agtatggaaa tgcatttcgt tagaacagaa
    30121 cctgaggcac gccgcatagc tgaaaccttt tgtgccgaaa acacacaaac aaaaacccct
    30181 atgcgcgtgc agcagttaag ctatccatca gacacagatc actcaggtgg tgagctatac
    30241 atctatgctt tgtctcctgc tggatttatc atcgtatcag gagataccag agcgcacacc
    30301 attttaggct attcttttga taataacctg gacctcaacc atgataatgt cagaagtatg
    30361 gtagaagctt accaaaaaca aatcaactct ttggattgat cggtcaaagt agcttttgcc
    30421 ccctcaccac tcgtttaaga cgaccgtgtt tctaaaatac cactaccttt taagtttcac
    30481 gccggcctaa gcaagtgttt gtctcatgga gcagactgtt tccatcgaaa agtcacccat
    30541 tgataaagga ggtcatcaac gcctactaat gatgacttcc ctaagatgcc aaggtaaagg
    30601 actgagttct gtagagatgg gactcagtcc ttttacgatt tttgggagtt attctagcca
    30661 taccgtggca agaaaacaac actcaaaaat agccaacgtc agtttctgtt catacatgac
    30721 tacagccaaa caccacaacc taacctatcc taaacacagt ggctttctaa cgaacagtca
    30781 caacgagcag caacaccaaa aagcaagatt aagctacgtt taagactaat gatataagat
    30841 aacagtaatt attaatgaga aaagaggctc aaaaggacat gaaacaaatg aataaactca
    30901 ttacaggagt ggtaacgctg gcgacagtcg tgaccttatc agcttgtcaa tcatcacaca
    30961 acaacaccaa actcgtctcg atgaaaggag acaccatcac tgtcagtgac ttctacaatg
    31021 agaccaaaaa cacagaactc gcacaaaaag ccatgttaag cttggtgatt agccgcgttt
    31081 ttgagacaca atatgccaac aaagtctctg acaaagaggt tgaaaaagcc tataaacaaa
    31141 ccgcagacca atacggtaca tcctttaaga cagtcctagc acaatcaggc ttaacgccag
    31201 aaacctataa aaaacaaatt cgcctcacaa aattagtcga atatgccgtc aaagaacaag
    31261 ccaaaaacga aaccatctca aaaaaagact accgtcaggc ctatgacgct tataccccaa
    31321 ccatgaccgc agaaatcatg cagtttgaaa aagaagagga tgccaaagca gcgcttgaag
    31381 ccgtcaaagc tgaaggggca gactttgcag ctattgccaa agaaaaaacc attgcagccg
    31441 ataaaaaaac aacctatacg tttgactcag gcgaaacaac cctaccagca gaagtagtta
    31501 gagctgcatc aggcctcaaa gaagggaaca gatcagaaat catcacagcg cttgatccag
    31561 ccatctcaaa acgcacctac catatcatca aagtcaccaa aaaagcaact aaaaaagcag
    31621 actggaaagc gtaccaaaaa cgcttgaaag acatcattgt gactggcaaa ttaaaagacc
    31681 ctgacttcca aaacaaagtc atcgctaaag ctcttgataa agcaaatgtc aaaatcaaag
    31741 acaaagcatt tgccaatatc ttagcccagt ttgcaaaacc taaccaaaaa caacctgccc
    31801 aaaaatagag ggttgccagt ttatttccct aaggttgctt aaaaagacag ccctagccat
    31861 cactcccctt ttcaaaacac cgataatgga aacgtgtcct atactgatgg tctagggcaa
    31921 tgtcataaag ctaaagactc tatccaaata aggatagagt ctttaatatt taaaaaccag
    31981 tcagcaaaaa aattcacgct aagcctagaa tgaggcttag cgtgaatggt atcagtgata
    32041 gtccgttaac atagctgatt gggagtcaga aactctaact acccaatctg actatacccc
    32101 cagtaccaga ggtgtctcat cgcagaagta gcaatcagat aatcgtctga taagctcttg
    32161 tcctcaagca actgatgagt gtcgtcgcac gggctatgag ctgccggtgg ctgatagcta
    32221 gtaggctcat cagccaaaac ttttttggag taacgctttg gtctcagacg gcgccagagg
    32281 gttgagagag gggtgagaaa aaaacgatgg gtcatcttgg cctccttgtc taatgatagt
    32341 cacgttaaca gacaaaagtg tcaataatgt cattttaagg agaaaaatat taaaaatcaa
    32401 ggtcacaaac tttcctttgt taaaaaaact cgaccctaac aaagaaccta aatacccctc
    32461 gcacttgagc ttctccttgc gcagctatct tttgtactca gttgcataca agctaatgat
    32521 agcgatacca ttattgtcct ataggctatc gcgacaaccc ctttttttcg cctcaatgag
    32581 gctgaaacag ctgtcatgac agagaaaaga cccttgtcta tctaagagac cattaatttt
    32641 tatctcacca aaaaactgat tttagaaaca aaaaatcatg gtgtataata aagttcggaa
    32701 caattatgac attataatga aagtaaggtt aacgaaacat tgacaaattg taagtataaa
    32761 cttagaaagt tatctgtagg gctcgtctcc gtcggaacga tgctgatagc cccgacagtt
    32821 ttaggacagg aggttagtac tagtgctagt agtactaaga cgagtgctag tactaatatt
    32881 aatactaata ctagtaccgc tagcgctggt accggtacga gtgggacggc ttccactact
    32941 cctagtgttg gtacaagtac tggtggagca gctgggggtg aagcagctgt agcatctagt
    33001 ggaggaagtc agagttcaga atctgcccaa gcctcaacac aacctcaagc acagacagct
    33061 gtagcagcat ctgcttccac tactgcgtcc ccttctagta gtgaagagaa aactcctaag
    33121 acagtaactt catctacctc atcgactcca gcagccagta gcagtagtaa tggcaaccaa
    33181 gtaactggta ctgaagttga accacagatg atggacgtgg aacagtataa ggttaataag
    33241 gaaaaaacag agcttactgt taaagatgac aaacagcagc tcaagatccg taaagatgtt
    33301 gatgaattaa aaaataaaga tctttttgat gtcaaacgtg aagtaaaaga taatggcgac
    33361 ggaaccttag atgtaacctt aaaagtaatg cctaaacaaa ttgacgaagg tgccgatgtt
    33421 atggcccttt tagatgtctc tcaaaagatg acacaggaga actttaataa ggctaaagaa
    33481 cagattaaaa gattagtcac aactttaaca ggcaaatcat ctgatggaaa ggaaaatcat
    33541 aataggcgta attctgtacg tttaatgacc ttctaccgta aaatcagtga accaattgat
    33601 ttatcaggaa aaactagcga cgaagtcgaa aaagagttaa ataagatatg ggataaagtc
    33661 aaaaaagaag attgggattg gggcgttgat ttacagggtg ctatccataa ggctcgagaa
    33721 atttttagat cttcttacga aaaaaagtcg ggcaaacgcc aacatatcgt cctgttctct
    33781 caaggcgagt caacctttag ttatgatatt aaaaataaaa atgataataa actcacaaaa
    33841 gcgagaatag aagaggaggt cacgtcctct aatcctcttt tatcctggcc accaattttt
    33901 aatcatacga atcgaaaagc agatatgctt aatgatatag agtatcttat aaaactaggt
    33961 gaaagattgg gaattacggg tctagatagt ttaaagaata cactgaagtt agcgtcgaca
    34021 ggaagttcta tagcaggctc acttttaggc agtggtagtc tgtcagagta ccttaccttg
    34081 aaggagtatg agtctagaac attgaaggaa agtaattttg attatactaa acgtgtgggc
    34141 gaagggtatt attatcatag cttttctgaa aggatacaaa acgagttacc acttaagtca
    34201 attatagagc ctcaactaaa aggattattt aaaacagagg atagtagttg gttcggtagg
    34261 tttctcaata agttttcatt agcgaagggt tatcaagaat ttaaagaaac tgccctttta
    34321 aaagttctcg aatatttgtt ctataaacgt gaatatattt actacaatca caatctctca
    34381 gcaatagctg aagccaaaat ggctcaacaa gaaggcatca ccttctactc cgttgatgtc
    34441 acgtctccaa atcagtcggc taataaaagg actaggaggt cagctgatac accggaggaa
    34501 aaacgtaaca aaaagtttga taattaccta aaagagatgt ccgaaggaag aaaattctta
    34561 gaaggtcagg atgtcacaaa taaagataaa tttaaagata ctttaacaga actaacgatt
    34621 aaagatgaat tcacagaaaa ggttacagtt cataaagata aagaatatta taaaactagt
    34681 ttaatagatg acagacctaa agtaacacat caagcccctt atagcagttg gttaaacagt
    34741 accaaagaaa gcctcacttg gaccatttcc aaagaccagt tgaaaaaagc ttttgaaagt
    34801 ggtcaaccat taaccttaac ttataagcta aaagtcgaga aggaaaaatt caaagaagca
    34861 ctaaaaaaac aacaagaacg aaaaaaacga gcagcatctc cggaaagtga gaatactgtc
    34921 acagacacaa ttatttcaaa taagatttct tacaagatta ataatggtac ggatataaat
    34981 agcaataaca ataagttgga agatgttaaa atgtcttaca gcaagttcaa gatgcctata
    35041 ccagaacttg atatagaagt tgtaccaata ccagaaaaac cactggtaga accaatgacg
    35101 cctctatatc ctgcaattcc taattaccca acaccagata tccctacccc tcaacttcca
    35161 aaagatgaag acctggagat tagtggaggt catggaccga ttgtcgatat cgtcgaagat
    35221 actggtacag gtgttgaggg cggcgctcaa aacggcgtgg tttcaactca ggaaaataaa
    35281 gatccaatcg ttgacatcac cgaagatacc caaccaggta tgtcaggctc taatgacgca
    35341 acagttgtcg aggaagacac aacacctaaa cgtccagatg ttcttgttgg tggtcaaagt
    35401 gatccaatcg acatcaccga agacacccaa ccaagtgtat caggctctaa tgacgctact
    35461 gttatcgaag aagatacgaa accaaaacgc ttcttccact ttgataacga gccacaagca
    35521 ccagaaaaac ctaaagagca accatctcta caagatagta acagcttacc acaagctcca
    35581 gcctataagg cagctcatca cttgcctgca tctggagaca aacgtgaagt atactttaca
    35641 attgctgctc taacaattat tggagctgca ggtttgctca gcaaaaaacg tcgcgacacc
    35701 gaagaaaact aaccctcgtt agtctagcga ccctaagcct ttggctttaa aaatttctca
    35761 ttatccccct caaacaccgg tacctcactg agatggcgct taaaaaagcc gctagtctca
    35821 aatcaggtat cccctacggt tgagggggat taatgggtat cacaacaaga aaaaaggtat
    35881 aatgatgaaa tatgactaaa aaatttatta aatcagcagt gattctaggc ttagcaagca
    35941 taaccatcag catgacgcaa cccgttgaag ccattgcaaa tcgcttagaa tatcaagaac
    36001 aatacgaacg tgtcaaaaaa gaactagacg cattaaaaga aaagggccca aaattaggag
    36061 aacgttccct ttattttaga gtggtgaata aatttctaag ttggtttggc caagtctggg
    36121 acccactcgc aatcgaagaa accgatcacc tgttggacct catcggacaa gtcaattact
    36181 tggtgagtaa caccgagttt caagcccctg agtaccaaga ggctaaaaac aaactagatt
    36241 tagctgtagc aggctatgac ctctacctat ctagagaaaa aggacgtggt gatgctcctg
    36301 attaccaagt gacccagcta acgctagaac agatcgcaac catcaaaacg aagatacaag
    36361 aggccctgaa aacatttgca caagaggtca aaacaatcca acaaacacac ccagacctat
    36421 ttccccatgc ttatgtttta aacgctaaga ccagtgctat cgatggtaaa gcgcaaccct
    36481 ttttagtgaa tggttactac gatgtctttt ataagcagtt tttattcact aatacaaagg
    36541 acgggtataa ctataataaa gaagcagaca atctgacctc gtatcaaaat ctgattaaag
    36601 aactattaga gttaaaaact aagatcgatc agttaacaac agacaagcct aaaaacgatc
    36661 ttttagagac gttaatgtgg caatcaaagt tcaccttatc tgactttcgg agaacttcac
    36721 gccttagcgc ctactataca caagaagatt atgtcaaaaa ggtggtccta tctgaagaag
    36781 ctcccaactt gagaacagca aaagaaaagg tcaagacctt aaaagggatc ttgcatgatt
    36841 actatgttga aactaatgat ttagaaaaag ctaaagagta tcatgtcgag gacgaaacct
    36901 caccgtctca acctgaggcc cctgctaaac ctgaagctcc tagtcctagt cctgctcctg
    36961 gtcaaaaacc agcagaagat gagagatcat cacaagctac ggaaccagct aacccgtcaa
    37021 aagaggattc ctcaacagac gcatctcagg gatctcacga tagtgaaaac ccagcgacag
    37081 acagtccttc tcaacctcag gcaccagacc aaggcaatca ccaaagccaa gtgcctaacg
    37141 acaagcctca aacggacaag acggacactc ctaacgtccc agcccctcca caggacaccc
    37201 caaaagtgcc tgaggctggt ggtcagagtg gccccgctgg gaacgctgag gagaaagctc
    37261 ctgactctgg acctaaagag tctgatcaaa gctcatctaa agagtcccca tccgttggcg
    37321 aagacacgac ccctaatcag ccagacgtcc ttgtaggtgg tcaaagtgag ccaattgata
    37381 tcaccgaaga cacaatcact gacgctcctc cgacagtatc tgggcacaac gcatcaacac
    37441 agccccaatc tgtggtcgaa gacacagcac ctcagcgccc agatgtcctt gtaggtggtc
    37501 aaagcgagcc aatcgatatc acccaagata cccaaccggg catgtcaggc tctaatgacg
    37561 ctaccgttat caatgaagat acaaaaccaa aacgcgtctt ccactttgat aacaaagagt
    37621 cacaagcatc agaaaaagcg gcagagcaaa aacttgctcc tcatgatagc cacacaaccc
    37681 ctcaagcttc agatgataca gcagcccctc acttgcctgc atctggagac aagcctgaaa
    37741 aagtgtttgc acttgctgcc ttgacaatgg tcgcagctgc agggctactc agcaaaaaac
    37801 gtcgcaacac cgacaaaaac tagtcgctgt taggcacaac gcatcactaa ggccagtgca
    37861 aatgcactgg ccttagttag gtttttatca aatagagggt ttttcatgac aattgctagc
    37921 atttcggtgt aaaataaagg taatagccag caaaggagca acccatgaca aagcaagatc
    37981 agttaatcgt tgaaaaaatg gaacaaacct atgagacctt tagcccaaag ctagcaaatc
    38041 tcatagaagc cctagatgcc tttaaagagc attatgagga atatgccaca cttagaaatt
    38101 tttacagtag tgacgaatgg tttcggcttg caaaccaacc ttgggatgat atcccgtgcg
    38161 gtgtcctatc tgaagacctc ctctttgata tgatcggtga ccataaccaa ctactagctg
    38221 atatcttaga cttggcccct atcatgtaca agcatatgta accatcgcta acgtcacaga
    38281 tactacgatg acaggacaaa aaaagcttga aaatctcaaa aaaaacagat aaaaaacaga
    38341 taatcgttag aaaaacagta gatgcgtctg ttaaactaaa ggtatcaaaa caaaaggagc
    38401 atttcatcat gaaattcaaa aaagtattag tcattcctgc attagcatta gcagcaacat
    38461 gctttttaac agcttgtggc acaaaaaaag attctaaaaa agaagaagtt aaagaaatca
    38521 aaatgtctga catcaaagac gacgcagtta gcaaaaaaac aaaagtggtt gatggcgaag
    38581 aagttacaga atacaccaca aaagatggaa acgtgattca gattcctgca ggaaacgaag
    38641 aaggcatgga atcaaaagat gctggtggat caggcgctcc tgctaaaaac taagggttac
    38701 aacaaagagc ataaggtgac tcgcaaacgt tacgcatgac atgaggcagt ctgcctaaga
    38761 tggtaactca cttatcataa tgcctaaata gccaaacaca ctaactcgca aatgtacaaa
    38821 atcatatacc cgtgcttatg tgagcgaacg gttatatgat ttttgttttc caaaaacaag
    38881 aaaagaacgc taaattagcc agtttgtcgt gtttcaagct accaaaaagg aagtgctaaa
    38941 atgaaaaaaa gatccattat acctgtcatc ttactgttgg tcatcggatt aatcgttggt
    39001 gttaagcgtc atcatgacta gtaggtcttg ctagtgaccg ttcaaaaggg ataacgttgg
    39061 tatggtataa ccataaaaat cgtataaaaa gaaaaaatag ctattgagga gaaagtatgt
    39121 ttcagttaag aaaaaaaatg acgcgcaaac aattagcctt gttgagtgct ggagtgttga
    39181 cttgtgtggt tggtggtagc tacttgataa tgaaccatca acaacaagaa attgtttcta
    39241 gtgtcaacaa agtaaaagcc ttaaccataa aagaagccat ggaacaagga aaagatatca
    39301 gcttgacctt agctggcgaa gtaacagcta acaacagcag caaagtcaaa atcgactcaa
    39361 gtaaaggaga agtcaaagat gtctttgtca aaaaaggcga tgttgtcaaa gtaggacaac
    39421 ccttgtttag ctatgaaacg tcacagcggt taacggctca aagttcagaa tttgatgttc
    39481 aaaccaaagc caatcaactc caagttgcta aaaccaatgc agcattgaag tgggaaacct
    39541 acaatcgcaa ggtcaatgaa atcaataccc taaaatctcg ctacaacact gcaccagatg
    39601 agagcttact agagcagatt cgcagcgcag aagacagtgt atcccaagca ctaagcgatg
    39661 ccaaaacagc agatagcgat gtcaaaactg ctcaaatcga actcgataaa gctaatgcta
    39721 ctgccacaac ggaaaaaggt aaactagagt atgacaccgt taagtcagac accgcaggaa
    39781 ccattgttag cctaaatact gatttgccaa atcaatcaaa atccaaaaaa gaaaatgaaa
    39841 cttttatgga aattatcgac aaatcaaaaa tgttagtcaa aggtaacatc agtgaatttg
    39901 accgtgacaa gttaaaaatc ggtcaaaaag tcgaagtgat tgaccgcaaa gacaactcta
    39961 aaaaatggac tggaaaagta acccaagttg gcaacctcaa agcagaggaa aaaggccaag
    40021 gtcaaggcca aggtggcaat gaccaacaag acaatccaaa ccaagcaaaa ttcccttatg
    40081 ttatcgaact tgaccaatca gacaagcagc cactcattgg ctcacacacc tatgttaatg
    40141 tgctcaacaa tgttccagaa gctggcaaga tcgtattgaa agaaaccttt acaatggcag
    40201 aaaatggaaa aacctatgtg tggaaagttg ataaaaacaa ggtcaaaaaa caagaaatca
    40261 agactaagcc cttctcaaaa ggttatgttg aggtaacaag tggcttgacc atgcaagata
    40321 agattgctca gccgcttcct ggcatgaaag acggtatgga ggtaggaagt attgttaaac
    40381 cttaaagata ttcgaaaaag ctatcatctt ggaactgaag aatttgcgat tttaaaagga
    40441 atcgatttag aagttaacga gggtgacttt ttagccatca tgggaccatc aggttcggga
    40501 aagtcaacat tgatgaatat cattgggtgt ttagataagc ctggctctgg ctcatatgcc
    40561 attgaaggca gagacgtgtc atccttatct gataatgaac ttgctgattt gcgtaatcaa
    40621 aaaatcggct ttgtttttca aaattttaac ctgatgccca agctaacagc ttgtcaaaat
    40681 gtcgaattgc ccttgactta tatgaatgtt cctaaaaaag aacgtcgcaa acgagcccta
    40741 gagatgttaa agctcgtagg attagaagaa cgtagtgaat ttaaaccgat ggagctatct
    40801 ggtgggcaaa aacagcgtgt agcgattgca agagctttag tcactaaccc gagttttatc
    40861 cttggtgatg agccaacagg tgcactagac acaaaaacca gcgtccaaat catggaccta
    40921 tttaaacaat tcaatgataa cggcaaaacg attattatca tcacacacga gcctgaagta
    40981 gctgccttat gcaaaaagac ggtgatccta agagatggta atatagaaca ttccgatata
    41041 gagtaaaggg ggaaaataat ggaagatatt attgcagctt taggctctat attatcacac
    41101 aagatgaggt caattttgac aatgctaggg attattatcg gtattggtgc cattatcgca
    41161 atcttttcaa tcatcgaagg taataccgaa aataccaaaa gacagttgat tggtggcagc
    41221 aataacacta ttaacattgt gtttaacaaa aaaagtagta ttgaccctaa atttccagac
    41281 aagtcaaatg ctaaaaaacc agactatctt ccttttatgg ctgaagaaga gcttagcaaa
    41341 atacagcaag tcaaaggcgt caaaaacgcc ctgatctcat atggtattga tgacaaagtc
    41401 taccatctag gccaaaaatc atctgcaaag atttctgcca tcacaaaaaa cgtagctgaa
    41461 gtgaggcgca tgacatttat taaaggcagt gacttttcag acaaagactt tattgaccaa
    41521 aaacaggtga tttaccttga aaaaagcttg tatgagtcac tatttccaaa agacgatggc
    41581 cttggaaaat ttgtcgaagt gatgggaaat cccttcaggg tcattggggt gtttgaatca
    41641 aaagaacaaa gtggcctcac aagtgggact gagaaaattg cttatatccc gctacatcag
    41701 tggtataata ttaatggtgt agtggatgcg acacctgaga ttacgatcca gacctatcgc
    41761 gcagatgacc tcaaacctgt agcaaagcgt gtcagtgata tgctcaatca aacgatccct
    41821 aaatcagatt atatgtttgg tgtcatgaac cttaaagaat ttgaacgcca actagacaac
    41881 ctaaacaaat ctaattttgt gttattagct ggtattgcta gcatctctct tattgtaggt
    41941 ggtattggtg tgatgaacat tatgctagta tcagttaccg aaagaacgag agaaattggg
    42001 atcaaaaaag cgcttggcgc tagacgtaag cttattttaa aacaattttt aattgaagcg
    42061 gtcattctaa ccttgctagg tggtgtgata ggggttattt cagggatggt atcaggattg
    42121 atcatcacaa gatcactcga gtatccctat atcctatcct tgttctcagt tgtcttgagt
    42181 ttagcgtttt gttgtattat agggattgtc tttggactat taccagccat taaagcgtct
    42241 aagctagacc caattgaagc attgcgattt gaataatcaa ccaaacaagc ataaaagtca
    42301 aaaaggatga ccctttgatg tcatccttag ctgcttgata cactaaacgc caatctagaa
    42361 agggaagtta tgtttaaaat attagtagtt gaagatgatg ataccatcag tcaagtgatt
    42421 tgtgagtttt taaaagcgaa taactatgat ccagattgtg tatttgatgg ccaagctgcc
    42481 ttagacaagt ggcagacaac gtcttatgat ctgattattt tagacatcat gctcccttcc
    42541 ttaagtggct tagaagtgct aaaaacaatt cgaaagacat cagatgtccc tattattatg
    42601 ctaacggcat tagatgacga gtacacacag cttgtaagct tcaaccattt gattagtgat
    42661 tatgtgacca aaccattttc accactcatt ttaatcaaac gtatcgaaaa tgtattacgc
    42721 gtctctactc cagatgaaaa gcgccaaatc ggagacttac ttgttgatga gaccgaacat
    42781 agcgtctatt ggcaaggaac attggtcaaa ctaaccaaaa aagaatatga cattattgat
    42841 tatttagcaa aacgtcacca aaaaattgtc accagagacc aattgatgga tgacatatgg
    42901 ggctattctg aactggacac gcgtgtcctt gacaaccaca tcaagaacct tcgtaaaaaa
    42961 atgacgggta ttcccctcaa gacaattaca ggcatgggct atttattggg agagcgtgag
    43021 tgagactaat caaaaaaacc tttttggtca tcaatggctt aattattgta gtggttacct
    43081 ctattttgtt agtgctttat tttgcaatgc caatttatta caccaaagtc aaagacaaag
    43141 aagttaagcg tgaatttgac caaacaagca agcaaatcaa aggcaaaacg gtaaccgaga
    43201 ttagagatat cctaacaaaa aaaatcaaca aagataatat ttggtacagc ttagtagaca
    43261 gtgataacca actgctctat ccctccttgc agctcctaga cggcgtcagt gaaagcaaag
    43321 acagtcaaaa tgttaatatc gtcaccacct ttgacaactc ttattctaat gttaaggtga
    43381 tgagtcaaaa agtaacccta cgcgatggaa aaaagatgac attgcttggg caatcttcac
    43441 ttcaacccgt aacagatgct agcaaagttc tccttgacct ctacccgtca ctattgatgt
    43501 tttcagtgac cgtagggagt attgtcgcct acttatatag taggacttct agccggcgta
    43561 ttcttagcat gtcacaaacc gccaaaaaaa tggtcaacct agaaccaaac ttaacgtgta
    43621 ccattcacgg caaagatgaa atagcaatgt tggctagtga tattaaccgt ttgtatgcga
    43681 gtctttcaac gagcatcaaa tccttgcaaa aagagtatga aaaagcttct gattcagaaa
    43741 gagagaaatc tgagttttta cgcatgacat cgcacgagct aaagacacca atcaccagtg
    43801 ttatcggaat gattgatgga atgctctata atgttggtga ctttgcagat cgtgacaaat
    43861 atttgcgaaa atgccgagac gtccttgaag ggcaagccca actggttcaa tccattttat
    43921 ctttatctaa gattgaaacc ctagcttctc aaaatcaaga actgttttca ctaaaaagca
    43981 gtctagaaga agaaatggaa gtctttctcg tcttatcaga actaaaacac ctcaaagtga
    44041 ctatcaatct cgaagaacaa ttcgtcaaag ccaataaagt atacctacta aaggcgatta
    44101 aaaatattat tgacaatgcc tttcactata ccaaaccagg cggccaagtg atgattcaac
    44161 taaaagacaa ccaactagtg attaaaaatg aagcagagac attattgaca caacagcaga
    44221 tgaaacagtt attccaaccg ttttatcgac cagattatag tcgtaacagg aaagacggtg
    44281 gtacaggatt ggggctgttt atcacccacc agattcttga tcagcatcat ctggcttatc
    44341 gctttgttgt tcttgatcaa agatggatgg tatttacgat tgattttcca tcccatcatg
    44401 acgattgatc cacactagta ggacgacaaa agtcatcaat cactaaccaa gtcttgacct
    44461 ttacccatca ttgtttaggc aagtataaaa aagaggagag aaatcatata tgaagaaaag
    44521 gaaattgtta gcagtaacac tattaagtac catactctta aacagtgcag tgccattagt
    44581 tgttgctgac acctccttgc gtaataacac atcatccact gatcagccta ctacagcaga
    44641 taatgatacg gatgacgaga gtgaaacacc acaaaaagat aaaaaaagca aggaaacagc
    44701 gtcgcagcac gacacccaaa aagaccataa gtcatcacac actcacccaa cccccccttc
    44761 aaatgatact aagcagaccg atcaggcatc atctgaagct actgacaaac caaataaaga
    44821 caaaaacaac accaagcaac caaacagcag tgatcagtct accccctctc ccaaagacca
    44881 gtcgtctcaa aaagagtcac aaaacaaaga cggccgacct accccatcac ctgatcaaca
    44941 aaaagatcag acacctgata aaacaccaga aaaatcagct gataaagccc ctgaaaaagg
    45001 accagaaaaa gcagttgaaa aaacaccaga gccaaatcgt gacactccaa aacccatcca
    45061 acctccttta gcagcagcag ctcctgtctt tgcaccttgg agagaaagtg acaaagacct
    45121 gagcaagcta aaaccaagca gtcgctcatc agcggcttac gtgagacact ggacaggtga
    45181 ctctgcctac actcacaacc tgttgtcacg ccgttatggg attactgctg aacagctaga
    45241 tggttttttg aacagtctag gtattcacta tgataaagaa cgcttaaacg ggaagcgttt
    45301 attagaatgg gaaaaactaa caggactaga cgttcgagct atcgtagcta ttgcaatggc
    45361 agaaagctca ctaggtactc agggagttgc taaagaaaaa ggagccaata tgtttggtta
    45421 tggtgccttt gacttcaacc caaacaatgc caaaaaatac agcgatgagg ttgctattcg
    45481 tcacatggta gaagacacca tcattgccaa caaaaaccaa acctttgaaa gacaagacct
    45541 caaagcaaaa aaatggtcac taggccagtt ggacaccttg attgatggtg gggtttactt
    45601 tacagataca agtggcagtg ggcaaagacg agcagatatc atgaccaaac tagaccaatg
    45661 gatagatgat catggaagca cacctgagat tccagaacat ctcaagataa cttccgggac
    45721 acaatttagc gaagtgccca taggttataa aagaagtcag ccacaaaacg ttttaaccta
    45781 caagtcagag acctacagct ttggccaatg cacctggtac gcctataatc gtgtcaaaga
    45841 gctaggttat caagtcgata ggtacatggg taacggtggc gactggcagc gcaagccagg
    45901 ttttgtgacc acccataaac ctaaagtggg ctatgtcgtc tcatttgcac caggccaagc
    45961 aggagcagat gcaacctatg gtcacgttgc tgttgtagag caaatcaaag aagatggttc
    46021 tatcttgatt tcagagtcaa atgttatggg actaggcacc atttcctatc ggacgttcac
    46081 agctgagcag gctagtttgt tgacctatgt cgtaggggac aaactcccaa gaccataacc
    46141 ccacaaccaa gaagctacct gcctgttgac caatctcaaa aagagacagc gtcaacttag
    46201 aatgaggttc atcagatgat aaagaaagtg accaccccga gtcaaaaaac aaaaaaacgt
    46261 gttcgtaatg gctatctcct aaaactaggt acagcctgtt tactcttaag tatactcagt
    46321 tatggcattg gtcttttggg ccagcctagc atggaaaata cgtttgtggg aatagcgagt
    46381 gttgccatgt taggaagtgt ctgtttcttt attatctttg ctctaaaccg tatctttgac
    46441 gcactagagg acaatttgcg agattagagt aataggtcaa ataatcttcc aataatttag
    46501 agcacaagct aagttattgg aagttttttt gtcttttgag agccatgatg ccatcaaaaa
    46561 gtcaaacact ccttatgatg tgagagtcac atggctaaaa ttaaaagcaa aatagacccc
    46621 aaagccctgt tttctcaaaa cagtcaacga aaaaagacaa gttaaccagt tcatgaaaaa
    46681 catcgtagaa acattttcaa gagctaatgt tggtgtaaat tgactgaagt atgatagaat
    46741 ttttaatgaa tgtgacaata atgtcacaga taaaaaccga aaacagcaaa aataattaaa
    46801 ttgaatataa aaaagttaat taagtgagtg ataataaaga aatgaagttc aaaaaatata
    46861 aataaagtaa aacaccagaa ctactaaaag cagtgaatga cataaatgtc gctaaaaaaa
    46921 tagatagaag agtctaaaat ttcagtttta ggtcacgttt tatgaatgga aatcaggatg
    46981 atgaccttaa gttgtgattt gcgcgtcgtt gaccgctttc ctcgttttaa tgaaagaatt
    47041 tgaaagatat tttatggtat acttttcctt aatatggttc atacggactt gataaatcta
    47101 tttacaaaaa taataaaaaa ttaagataag gacatgaagt taatgcatgt aagtaaattg
    47161 tttactagcc aacaatggag agaattgaaa ctgatttcat atttaacaga aaactctaat
    47221 gctatcggag ttaaagataa ggagcttagc aaggctctca atatttccat gttaacatta
    47281 cagtcatgcc tcactaatat gcagttcatg aaagaagtag gtggaattac ctacaaagac
    47341 ggctatatta atatttggta tcaccagtgt tgtgggctac aagaggtcta tcaaaaagct
    47401 cttcgagaat cgccttcttt gaaattacta gagcttttgt ttttcagaga ctttagttcc
    47461 ttagaagagt tagctgaaga gctgtttgtc agcttatcta ccctcaaacg cctcatcaaa
    47521 aaaaccaaca cttacttgtc tcataccttt gctattagta tcgtgacaag tccagtgcag
    47581 gtgtcaggag atgagaggca aatccgcctg ttttacctca agtatttttc agaagcctat
    47641 aaaatctcag aatggccatt tggggacatt ttaaacctga aaaactgtga acgcctattg
    47701 agcttattga tcaaagaagt agatgtcaaa gttcatttta cactatttca gcacttaaaa
    47761 atcttaagtg gtgtcaactt gatccgttac tacaaggggt attcttgcag ttataacaat
    47821 aaaaaaacca gtcaccgttt ttctcaactt atccaacatt cctcagaaat ccaggatctt
    47881 tctcgcttgt tctacctcaa atttgggtta catctcgacg agtataccat agctgaaatg
    47941 ctttctaacc atcttaacga caagctagaa attggctgtg cttttgagat tatcaatcaa
    48001 gacccgacat caggaggcag acaagtaacc aactggatcc atctattaga tgagatggaa
    48061 atcaagctca atctcagcat caccaataaa tacgaagttg ccgtgaccct ccataacgct
    48121 tcggtgttaa acgaagaaga cattacagcc aattatttgc tgtttgatta taaaaagagt
    48181 tacctgaact tttaccaaaa agaacaccct cgcatttatg aggcctttgt gacaagtgtc
    48241 gagaagctga tgcaggcaga taatgctcaa gttagcaaag aactgatcaa tcagctcact
    48301 tattgtttct ttattacctg ggaaaatagt ttcttaaaag taaatcaaaa agatgaaaaa
    48361 gtacgactcc tagtgataga gagaagttac aatagtgtcg gtaatttttt gaaaaagtac
    48421 atcggtgagt tttttagcat cacgaacttt gatgagttag attgtttgac aattgatcta
    48481 gtagagattg aaaaacagta cgatgttatc gtgacagatg ttatggtggg taaaagcgaa
    48541 gagttagaga ttttcttttt ctacaagatg attccagaag ctattattga tagattaaac
    48601 gaatttttga acgttagttt cacagataac aacgttatgg tcaaaaacct cgaagcccct
    48661 tcctcttcaa aatctcatag tgacaaagag gtacaaaagc cagaaaagcc agacaattca
    48721 gttaaacaag caacatcatc ataggatttc agacgtcatg gtaagaaaaa aaagaatcat
    48781 ttacagccca tagaggtaag gtcaaaagct gaaaacagct caaaaaaact gacctttacc
    48841 ttttggcttt ttttatttag aataatttta ttggagagat gcttaataat ttaagcacaa
    48901 ttcttagaaa ttgagaaata aggagtaaac aatgtctaaa agaaatccaa acaaactcta
    48961 ttcactgaga aagttaaaaa caggtactgc atcagtagca gtagccttga cagttttggg
    49021 gactggatta gcaaacacaa ctgatgtaaa ggctgagagt cgtcgttatc aggcacctcc
    49081 tcgtgtgtta ctgcaaggca aagaagctaa caaagtattc gaagagcgca aagccttgga
    49141 aaaacaagca cgtgatttgg gtgacactat taaccacatg tcacaaacca ttagcgagca
    49201 aagccgcaag attgcagcac taaagtctga agcagaactt aaaaaccaac aagctcttga
    49261 agctttaaac aataaaaaca agcaaatctc agatttaacc aacgaaaacg cacagttaaa
    49321 agaagccatt gaaggttatg tgcaaactat ccaaaacgct agtcgtgaaa tcgcagcaaa
    49381 acaacaagaa cttgcagctg caaaaagcca gttagaggca aaaaatgctg agattgaggc
    49441 attgaaacaa caagatgcct ctaagactga ggaaattgct aaattgcaat cagaagcagc
    49501 aactttagaa aacctcctag gttcagctaa gcgtgagttg actgaattgc aagctaagct
    49561 agatacagca actgctgaaa aagcaaaact agaatcacaa gtaacaacct tagaaaacct
    49621 cctaggttca gctaagcgtg aattgactga tctgcaagct aagctagatg cagctaacgc
    49681 tgaaaaagaa aagctccaat cacaagcagc aaccctagaa aaacaactag aagcaactaa
    49741 aaaagagtta gctgatttac aggctaaatt agcagcaacc aaccaagaaa aagaaaagtt
    49801 agaagctgaa gcaaaagctc ttaaagagca attggctaaa caagctgaag agcttgctaa
    49861 gctaaaagca gataaagctt caggagctca aaaaccagat actaaacctg gcaataaaga
    49921 ggttccaaca agaccgtcac aaacaagaac aaacactaat aaagctccta tggctcaaac
    49981 aaagagacaa ttaccgtcaa caggcgaaga aacaaccaac ccattcttca ctgcagcagc
    50041 attgacagtg atcgcatctg caggtgtact tgccctaaaa cgcaaagaag aaaactaagt
    50101 ccaacccaca ttatcttttc tagcccaaga aaaaaacaaa aaaagaggaa gccccttcct
    50161 ctttttttga acggttaaac agcaaaaagg tcaaaaaggc actaaagtct caaaaacctg
    50221 gtctttacct tttaccgctc attctttaga atagaattat tagagagaag tcttagaaaa
    50281 atgaggctaa ttccctaaaa gatgaaaaaa ataaggagca aataatggct agaaaagata
    50341 cgaataaaca gtattcgctt agaaaattaa aaacaggtac agcatcagta gcggtcgctg
    50401 tggctgtttt aggagcaggc tttgcaaacc aaacagaagt taaggctgcg gagattaaaa
    50461 agcctcaggc tgattcagcg tggaactggc ctaaagaata taacgcgtta cttaaggaaa
    50521 atgaggagct caaggtagaa cgtgaaaaat atctatctta tgctgacgat aaagaaaaag
    50581 atcctcaata tagagcatta atgggtgaaa atcaagatct tcgaaaaaga gagggacaat
    50641 atcaggacaa aatagaagaa cttgaaaaag aaagaaaaga aaaacaagaa agacaagaac
    50701 aattagaacg tcaatatcaa atagaagcag ataagcatta tcaagaacaa caaaagaaac
    50761 atcagcaaga acaacaacaa ttagaagcag aaaaacaaaa attagctaaa gacaaacaaa
    50821 tctcagacgc aagccgtcaa ggcctaagcc gtgaccttga agcttctcga gcagctaaaa
    50881 aagaactaga agctaagcac caaaaatt
//
LOCUS       DAUDWO010000010        48176 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.010, whole genome shotgun sequence.
ACCESSION   DAUDWO010000010 DAUDWO010000000
VERSION     DAUDWO010000010.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 48176)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 48176)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..48176
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.010"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(142..297)
                     /locus_tag="VHC05_000519"
     CDS             complement(142..297)
                     /locus_tag="VHC05_000519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type A2 lantipeptide"
                     /protein_id="HEQ5401855.1"
                     /translation="MSFMKNSKDILTNAIEEVSEKELMEVAGGKKGSGWFATITDDCP
                     NSVFVCC"
     gene            complement(800..2206)
                     /gene="lacG"
                     /locus_tag="VHC05_000520"
     CDS             complement(800..2206)
                     /gene="lacG"
                     /locus_tag="VHC05_000520"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002288409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HEQ5401856.1"
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWY
                     TAEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGDVNPKGVEYYHNLFAE
                     CHKRHVEPFVTLHHFDTPEALHSDGDFLNRENIEHFVNYAEFCFKEFSEVNYWTTFNE
                     IGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDGGYSGEIGVVHAL
                     PTKYPFDANNPDDVRAAELEDIIHNKFILDATYLGKYSDKTMEGVNHILEVNGGELDL
                     REEDFVALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRR
                     KAPVDVPKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDD
                     GRIDYVKKHLEVISDAISDGANVKGYFMWSLMDVFSWSNGYEKLYGLFYVDFETQERY
                     PKKSAYWYKKVAETQVIE"
     gene            complement(2294..3991)
                     /locus_tag="VHC05_000521"
     CDS             complement(2294..3991)
                     /locus_tag="VHC05_000521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEQ5401857.1"
                     /translation="MNGLIAQIEKGKPFFEKISRNIYFRAIRDGFITGMPVILFSSIF
                     ILIAYVPNAWGFHWSKDIENLLMTPYNYSMGILGLFVAGTTAKALTDSMNRSLPSTNQ
                     INFMSTMLAAIVGFLLMAANPAKDGGFLTGFMGTKGLLTAFIAAFITVNVYKTCVKNN
                     VTIRMPEEVPPNISQVFKDLIPFTLSVVLLYVIELIVHTTLGVNVAESIGKLLAPLFQ
                     AADGYVGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAETNLQLLQAGEHADKIL
                     TSGTQMFIVTMGGTGATLVVPFMFMWLTKSKRNKAIGRASVVPTFFGVNEPILFGAPL
                     VLNPIFFIPFILAPIVNVWIFKFFIDTLGMNSFTANLPWTTPAPLGLILGTNFQVLAF
                     ILAALLIVVDVIIYYPFLKVYDEQILTEEAAGTNSSDALKEKVAANFDTKKADAILEK
                     SAAKETKEITDQTNVLVLCAGGGTSGLLANALNKAAKEYGAPVTAAAGSYGAHREILP
                     QYQLVILAPQVASNYEDMKVETDKLDIKLAKTEGAQYIKLTRDGQGALDFVKAQFEN"
     gene            complement(3991..4308)
                     /locus_tag="VHC05_000522"
     CDS             complement(3991..4308)
                     /locus_tag="VHC05_000522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006739201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEQ5401858.1"
                     /translation="MNREETTLLGFEIVAYAGDARSKFLEALKAAQEGDYAKAEELIA
                     AGSDCLNDAHNAQTSLLQKEAAGDDLAYSVTLMHGQDHLMTTILLQDLMKHMIELYKR
                     GAK"
     gene            complement(4332..5315)
                     /gene="lacD"
                     /locus_tag="VHC05_000523"
     CDS             complement(4332..5315)
                     /gene="lacD"
                     /locus_tag="VHC05_000523"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="HEQ5401859.1"
                     /translation="MTITLTENKRKSMEKLSIDGVISALAFDQRGALKRMMAQHQTKE
                     PTVEQIEELKSLVSEELTPFASSILLDPEYGLPASRVRSEEAGLLLAYEKTGYDATTT
                     SRLPDCLDVWSAKRIKEAGAEAVKFLLYYDIDGDQDVNEQKKAYIERIGSECRAEDIP
                     FYLEILTYDEKIADNASPEFAKVKAHKVNEAMKVFSKERFGVDVLKVEVPVNMKFVEG
                     FADGEVLFTKEEAAQAFRDQEASTDLPYIYLSAGVSAKLFQDTLEFAAESGAKFNGVL
                     CGRATWAGSVKVYIEEGPQAAREWLRTEGFKNIDELNKVLDKTASPWTEKM"
     gene            complement(5319..6248)
                     /locus_tag="VHC05_000524"
     CDS             complement(5319..6248)
                     /locus_tag="VHC05_000524"
                     /EC_number="2.7.1.144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="HEQ5401860.1"
                     /translation="MILTVTLNPAIDVSYPLDELKCDTVNRVVDVTKTPGDKGLNVCR
                     VLNDFGETVKATGCIGGESGDFIINHLPDSILSRFYKISGDTRTCIAILHEGNQTEIL
                     EKGPLLSVEEIDGFTHHFKYLLNDVDVVTLSGSLPAGMPDDYYQKLIGIANLNGKKTV
                     LDCSGNALEAVLKGDSKPTVIKPNLEELSQLLGKEMTKDFEALKEVLQDELFEGIEWI
                     IVSLGADGVFAKHNDTFYNVDIPKIEIVSAVGSGDSTVAGIASGLANDEDDRALLTKA
                     NVLGMLNAQEKTTGHVNMANYDKLYQSIKVKEV"
     gene            complement(6296..6811)
                     /gene="lacB"
                     /locus_tag="VHC05_000525"
     CDS             complement(6296..6811)
                     /gene="lacB"
                     /locus_tag="VHC05_000525"
                     /EC_number="5.3.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012027025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="HEQ5401861.1"
                     /translation="MKIAVGCDHIVTYEKIAVVDYLKTQGHEIIDCGTYDNVRTHYPI
                     FGKKVGEAVASGEAELGVVICGTGVGITNAVNKVPGIRAALVRDMTSAIYSKEELNAN
                     VIGFGGKIIGGLLMNDIIDAFLAAEYKPTEENKKWIEKMDSLQHASQDQNNPHFFDEF
                     LEKWVRGEYHD"
     gene            complement(6846..7274)
                     /gene="lacA"
                     /locus_tag="VHC05_000526"
     CDS             complement(6846..7274)
                     /gene="lacA"
                     /locus_tag="VHC05_000526"
                     /EC_number="5.3.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="HEQ5401862.1"
                     /translation="MAIIIGADKAGQELKEVIKDYLKEGKYEVVDVSENEVRDFVDTT
                     LAVAKEVNASEDNLGIVIDAYGVGSFMVATKIKGMVAAEVSDERSAYMTRGHNNSRII
                     TLGSEISAPGIAKNIIKGFVEGKYDGGRHQVRVDMLNKMC"
     gene            7720..8493
                     /locus_tag="VHC05_000527"
     CDS             7720..8493
                     /locus_tag="VHC05_000527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004270277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEQ5401863.1"
                     /translation="MKKKERHEKILDILKVDGFIKVKDIIDEMNISDMTARRDLDTLA
                     DKGLLIRTHGGAQYLDYSSAKDEGHEKTHTEKKVLQTTEKKQIAQRAKNIIKDGETVF
                     IGPGTTLEHLAVELKNRNIRVITNSLPVFLILHPSTTIDLILIGGECREITGAFVGAI
                     AINNLESLTFSKAFVSANAVYNNSIATYSDLEGEVQRVALNNAVEKILLVDSTKFESY
                     DFYNFYQLDQVDLIVTDKNVTTGIIEKYKKFSKIIIADK"
     gene            9143..9430
                     /locus_tag="VHC05_000528"
     CDS             9143..9430
                     /locus_tag="VHC05_000528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-damage-inducible protein J"
                     /protein_id="HEQ5401864.1"
                     /translation="MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNV
                     VVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQGKFYTSEEVRAELGL"
     gene            9420..9755
                     /locus_tag="VHC05_000529"
     CDS             9420..9755
                     /locus_tag="VHC05_000529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="HEQ5401865.1"
                     /translation="MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISD
                     IEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKDYIVLYHIEGEENRVAIDYLLPT
                     QSDYIKLFK"
     gene            9894..10070
                     /locus_tag="VHC05_000530"
                     /pseudo
     CDS             9894..10070
                     /locus_tag="VHC05_000530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017827921.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
     gene            complement(10201..10593)
                     /gene="rpsI"
                     /locus_tag="VHC05_000531"
     CDS             complement(10201..10593)
                     /gene="rpsI"
                     /locus_tag="VHC05_000531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002942223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S9"
                     /protein_id="HEQ5401866.1"
                     /translation="MAQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADL
                     RLIINQPFAVTSTEGSYDVFVNVVGGGYGGQSGAIRHGIARALLQVDPDFRDSLKRAG
                     LLTRDARMVERKKPGLKKARKASQFSKR"
     gene            complement(10614..11060)
                     /gene="rplM"
                     /locus_tag="VHC05_000532"
     CDS             complement(10614..11060)
                     /gene="rplM"
                     /locus_tag="VHC05_000532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L13"
                     /protein_id="HEQ5401867.1"
                     /translation="MNKTTFMAKPGQVERKWYVVDATDVPLGRLSAVVASVLRGKNKP
                     TFTPHTDTGDFVIVINAEKVKLTGKKATDKVYYTHSMYPGGLKSITAGELRSKNAVRL
                     IEKSVKGMLPHNTLGRAQGMKLKVFVGGEHTHAAQQPEVLDISGLI"
     gene            complement(11278..11484)
                     /locus_tag="VHC05_000533"
     CDS             complement(11278..11484)
                     /locus_tag="VHC05_000533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5401868.1"
                     /translation="MKNLKLKAARAGKDLSQQALADLVGVSRQTIAAVEKGDYNPTIN
                     LCIAICRVLDKTLDDLFWEADDSH"
     gene            complement(11481..12179)
                     /locus_tag="VHC05_000534"
     CDS             complement(11481..12179)
                     /locus_tag="VHC05_000534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401869.1"
                     /translation="MFDSKQNLAKSQWMFIIITAVMDLVVLVATLLAKTSFQRYLVGG
                     VAVILTSFLILLVWGLKTAKKLQTRLDSKEILDSKVRDDQKLPRYDERQKQILLKGYT
                     IGFWFMIVAVWLSIFLHRFSERLVSASFLFTLALWGGLAVQTTYCNLNGVSPFVDRRF
                     GKQGILVGMIATGMSLVTIGLAVREMMAGQLKMGSFFKAGGSGSLMVLGITLLSMGAS
                     IFYRHYLDAKEADE"
     gene            complement(12315..13175)
                     /locus_tag="VHC05_000535"
     CDS             complement(12315..13175)
                     /locus_tag="VHC05_000535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEQ5401870.1"
                     /translation="MTFTIMTDSTADLNQTWAEDHDIVLIGLTILCDGEVYETVGPNR
                     ISSDYLLKKMKAGSHPQTSQINVGEFEKVFREHAKNNKALLYLAFSSVLSGTYQSALM
                     ARDLVREDYPDAVIEIVDTLAAAGGEGYLTILAAEARDSGKNLLETKDIVEAVIPRLR
                     TYFLVDDLFHLMRGGRLSKGSAFLGSLASIKPLLWIDEEGKLVPIAKIRGRQKAIKEM
                     VAQVEKDIADSTVIVSYTSDQGSAEKLREELLAHENISDVLMMPLGPVISAHVGPNTL
                     AVFVIGQNSR"
     gene            complement(13272..13790)
                     /locus_tag="VHC05_000536"
     CDS             complement(13272..13790)
                     /locus_tag="VHC05_000536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NYN domain-containing protein"
                     /protein_id="HEQ5401871.1"
                     /translation="MKKRILLVDGYNMIAFWQSTRQLFKTNQLDQARNTLLTKLNHYA
                     HFENINIICVFDAQYVPGLRQRYDQYYISVVFTEEDETADSYIERMAAELNTAIHMVE
                     VATSDLNEQWTIFSQGALRVTARELEQRVHTVKADLDKMSRDIDLKTPKLRPFDQGQL
                     SQLKDFMSQLDR"
     gene            complement(13794..14540)
                     /gene="rlmB"
                     /locus_tag="VHC05_000537"
     CDS             complement(13794..14540)
                     /gene="rlmB"
                     /locus_tag="VHC05_000537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (guanosine(2251)-2'-O)-methyltransferase RlmB"
                     /protein_id="HEQ5401872.1"
                     /translation="MEDKDTIETNDIVYGVHAVTESLQANTGNKLYIQEDLRGKKVDN
                     IKSLATQKKVAISWTPKKTLSQMTDGAVHQGFVLRVSAFAYTDVDEILEIAEQEANPL
                     ILILDGLTDPHNLGSILRTADATNVCGVIIPKHRSVGVTPVVSKTSTGAVEHIPIARV
                     TNLSQTLDKLKARGFWIFGTDMNGTPSDCWNTNGKLALVIGNEGKGISTNIKKQVDEM
                     ITIPMNGHVQSLNASVAAAILMYEVFRNRR"
     gene            complement(14587..15384)
                     /locus_tag="VHC05_000538"
     CDS             complement(14587..15384)
                     /locus_tag="VHC05_000538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401873.1"
                     /translation="MTTMQKTVSLLSLALLIGLLGTSGKAISVYAQDQHTDNVIAEST
                     ISQVSVEASMRGTEPYIDATVTTDQPVRQPTQATITLKDASDNTINSWVYTMAAQQRR
                     FTAWFDLTGQKSGDYHVTVTVHTQEKAVTGQSGTVHFDQNKARKTPTNMQQKDTSKAM
                     TNSVDVDTKAQTNQSANQEIDSTSNPFKSATNHRSTSLKRSTKNEKLTPTASNSQKNG
                     SNKTKMLVDKEEVKPTSKRGFPWVLSGLVVSLAAGLFIAIQKVSRRK"
     gene            complement(15580..15993)
                     /locus_tag="VHC05_000539"
     CDS             complement(15580..15993)
                     /locus_tag="VHC05_000539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mini-ribonuclease 3"
                     /protein_id="HEQ5401874.1"
                     /translation="MTNPVDVNLINGIALAFEGDAVYSCYVRRHLIFQGKTKPSQLHR
                     LATRYVSAKAQANLIQAMLEAQLLTEKEEDIYKRGRNTNSHTKAKNADIITYRMSTGF
                     EAIMGYLDMMGQKERLEELIRWCIEYVEKQQLISS"
     gene            complement(15986..17329)
                     /locus_tag="VHC05_000540"
     CDS             complement(15986..17329)
                     /locus_tag="VHC05_000540"
                     /EC_number="6.1.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000591125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine--tRNA ligase"
                     /protein_id="HEQ5401875.1"
                     /translation="MIKIYDTMTRSLHKFVPLTENTVNMYVCGPTVYNYIHIGNARSA
                     VAFDTIRRYFEYTGYQVNYISNFTDVDDKIIKAATQAGVSPKELSDRFIAAFIEDTKA
                     LGVKPATQNPRVMDYIAEIISFVESLIEKDFAYEADGDVYFRVEKSEHYAKLANKTLS
                     ELEVGASGRTDAETALKENPLDFALWKSAKAGEVSWDSPWGFGRPGWHIECSVMATEI
                     LGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKTFANYWMHNGFVTVDNEKMSKSLGNF
                     VTVHDMLQTVDGQVLRFFLATQQYRKPINFTEKAIHDAEINLKYLKNTLQQPLTETAD
                     EQELKQFVIAFQDAMDDDFNTANGITVVFDMAKWINSGSYTEPVKSAFEKMLAVFGII
                     FEEEVLEVDIEALIAKRQEARANRDFATADAIRDQLAAQGIKLLDTKDGVRWLRD"
     gene            complement(17357..17587)
                     /locus_tag="VHC05_000541"
     CDS             complement(17357..17587)
                     /locus_tag="VHC05_000541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401876.1"
                     /translation="MNKIRVGLYVIMSLSILVSSITLVASLIFLLKQDMVKAIIYFIL
                     TLFWLIGLVINIKLLKRWNSISEKDLGYQDDN"
     gene            complement(17930..18511)
                     /gene="cysE"
                     /locus_tag="VHC05_000542"
     CDS             complement(17930..18511)
                     /gene="cysE"
                     /locus_tag="VHC05_000542"
                     /EC_number="2.3.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine O-acetyltransferase"
                     /protein_id="HEQ5401877.1"
                     /translation="MGWWKESIAIVKALDPAARNSLEVILTYPGIKALAAHRLSHFLW
                     RHHFKLLARMHSQFWRFWTQIEIHPGAQIAPGVFIDHGAGLVIGETAIVEKGVMLYHG
                     VTLGGTGKDCGKRHPTIRQGALISAHAQVIGPIDIGANAKVGAAAVVLSDVPEDVTVV
                     GVPAKIVRVHGQKDNRQIQSLQKQREVSYQLSK"
     gene            complement(18520..19272)
                     /locus_tag="VHC05_000543"
     CDS             complement(18520..19272)
                     /locus_tag="VHC05_000543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SseB family protein"
                     /protein_id="HEQ5401878.1"
                     /translation="MTKSNELDIRLRAFINAPDNFLDSLALVNAFHNFPVWAAKEPYV
                     IEVEGVKVTPVFTDKEDMARFKEEQKSAQSQYWLERSALAVLEEVITSGAAGLVFNLK
                     KKGDFGNSTIFKSSDMIQFMNHYTTVLNTLMSDDNVAADTMEKVYLVPAFVYPKDDNH
                     YDRLFPTMSTPEGKSYVPAFSNLQSFAKWYNQDDFGGLFRKAEGVILTWTIDDIYQPR
                     NGENELDETFGVAINPFDDQQILVDWSELDKS"
     gene            complement(19265..21397)
                     /gene="pnp"
                     /locus_tag="VHC05_000544"
     CDS             complement(19265..21397)
                     /gene="pnp"
                     /locus_tag="VHC05_000544"
                     /EC_number="2.7.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018366801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="HEQ5401879.1"
                     /translation="MSKQTFTTTFAGKPLVVEVGQVAKQANGATVVRYGDSTVLTAAV
                     MSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFA
                     EGFRNEVQVINTVLSYDENASAPVAAMFGSSLALSISDIPFNGPIAGVQVGYIDGEFI
                     INPDKEQMEASLLELTVAGSKEAINMVESGAKELSEDIMLEALLKGHQAIQELIAFQE
                     QIVAVVGKEKAEVELLQVDADLQADIVAKYNAQLQKAVQVEEKKAREAATEAVKEMVK
                     AEYEERYAEDENLATIMRDVAEILEQMEHAEVRRLITEDKIRPDGRKIDEIRPLDAVV
                     DFLPKVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLAPEYKKRFLHHYNFPQYSVGE
                     TGRYGAAGRREIGHGALGERALEQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGT
                     LALMAGGVPIKAPVAGIAMGLISDGTNYTVLTDIQGLEDHFGDMDFKVAGTREGITAL
                     QMDIKIAGITPQILEEALAQAKKARFEILDVIEATIAEPRPELAPTAPKIDTIKIDVD
                     KIKVVIGKGGETIDKIIAETGVKIDIDDEGNVSIYSSDQAAIDRTKEIIAGLVREAKV
                     GEVYHAKVIRIEKFGAFVNLFDKTDALVHISEIAWTRTANVSDVLEVGEDVDVKVIKI
                     DEKGRVDASMKALIPRPPKPEKKEEKHD"
     gene            complement(21677..22408)
                     /locus_tag="VHC05_000545"
     CDS             complement(21677..22408)
                     /locus_tag="VHC05_000545"
                     /EC_number="2.2.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transaldolase"
                     /protein_id="HEQ5401880.1"
                     /translation="MMTKKLNVKVFSDGAVLETMLKDLQTGLVTGFTTNPSLMKKAGI
                     SSYIGFAKEVLAKITDYPVSFEVFADDLASMEKEAEKIASLGDNVYVKIPVTTSTGES
                     TCPLIQKLSAKGIKLNVTAIFTIEQTQAVVDHLTAGVPAIVSVFAGRIADTGVDPMPI
                     MEEALRICRQKEEVELLWASPRETYNIYQADQLGVDIITCTTDLIAKLPLQGKDLEDY
                     SLEAVQMFLKDSTSLGFKILEDAKH"
     gene            complement(22418..23797)
                     /locus_tag="VHC05_000546"
     CDS             complement(22418..23797)
                     /locus_tag="VHC05_000546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEQ5401881.1"
                     /translation="MEALLSFIRDILKEPAFLMGLIAFAGLVALKTPAHKVLTGTLGP
                     ILGYLMLAAGAGVIVANLDPLAKLIEHGFSITGVVPNNEAVTSVAQKILGVETMSILV
                     VGLLLNLAFARFTRFKYIFLTGHHSFFMACLLSAVLGAVGFKGSLLIILGGFLLGAWS
                     AISPAIGRQYTLKVTDGDEIAMGHFGSLGYYLSAWFGSKVGKDSKDTEDLQISEKWSF
                     LRNTTISTGLIMVIFYLVATVASVLRNASVTEELAAGQNPFIFAIKSGLTFAVGVAIV
                     YAGVRMILADLIPAFQGIANKLIPNAIPAVDCAVFFPYAPTAVIIGFASSFVGGLLGM
                     LILGVAGGVLIIPGMVPHFFCGATAGIFGNSTGGRRGAMIGAFANGLLLAFLPAMLLP
                     VLGKLGFSNTTFGDVDFGVLGILLGRLGTSIGQIGIYLVVAVLAIVLVLPNFLSKSQE
                     AINNVSEEI"
     gene            complement(23824..24108)
                     /locus_tag="VHC05_000547"
     CDS             complement(23824..24108)
                     /locus_tag="VHC05_000547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEQ5401882.1"
                     /translation="MIKIVTVCGNGIGSSLLLRMKVEAIASSLGIDVDAESCDSNAAV
                     GKGADLFVTVKEFKDIFPEDAKVCIVKSYTNRKKIEEDLVPVLKEMSGKE"
     gene            complement(24101..26161)
                     /locus_tag="VHC05_000548"
     CDS             complement(24101..26161)
                     /locus_tag="VHC05_000548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HEQ5401883.1"
                     /translation="MLSHELIRNYQLFSKYKGHSLEAFESMLKTSKRHILADIAKIND
                     TLSLYQLPLIALDRQLVYPPDLTEKDLLNRMLPTLDDYLFQDERLDMIIIYIMMAKEF
                     ISINHLESLLRLSRNSVIADLNLVRDRVQAFQVTLAYNRQDGYFFEGEPLALRRLLES
                     AVSSLLQVTSGPWVFSYLLHELGLPDQTKVMAATLEELSRENHLTFISEKLRDLIYFF
                     CLLAHRPFSRNVRAEAVDTFPLASPAVETMVDQLLVNFPSLTEEKYLVQSRLLGCIQG
                     DLELVFQQPIYDIMEEIINSVAVNTGLSITDTPELRQNLYSHLLPAYYRLYYDINLTN
                     PLKEQIKQDYESLFYLVKRSLSPLEKQLGKLVNEDEVAYFTIHFGRWLQAPKKRPSNQ
                     LVALSVCPNGISSSLMLEATLKELFPQLQFIRIHQLDKIKLLDPASFDLIFSTVAFDC
                     AKPVYVTQALMGPVEKMMLKKMVCDDFHLPLSEQFALDDLLSIIHKHTTITNKEGLVS
                     DLSRYLIGNHLTIEKGGLGLLDLLTADFIRQADAVSDWQEAIRLAAQPLLEHQMIETS
                     YIDGMIDSVNELGAYIVLTPKVAVPHAAPEKGTRQLGMSLLQLKEPVSFDLKQEGDPD
                     KQVQLIFVLSAVDSSSHLKALQELSLILDDDEHIEQLIEAKNTEEIMSLISHMIEKGD
                     ESHD"
     gene            complement(26513..26782)
                     /gene="rpsO"
                     /locus_tag="VHC05_000549"
     CDS             complement(26513..26782)
                     /gene="rpsO"
                     /locus_tag="VHC05_000549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S15"
                     /protein_id="HEQ5401884.1"
                     /translation="MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNNHIK
                     EHKKDHATYRGLMKKIGHRRNLLAYLRRTDVNRYRELIQSLGLRR"
     gene            complement(26941..27096)
                     /locus_tag="VHC05_000550"
     CDS             complement(26941..27096)
                     /locus_tag="VHC05_000550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401885.1"
                     /translation="MTMLGYRLSAEVRGSAILPLLAGYLIRQAIAQVYSDLKTASWLF
                     GLASSVA"
     gene            27222..27479
                     /locus_tag="VHC05_000551"
     CDS             27222..27479
                     /locus_tag="VHC05_000551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEQ5401886.1"
                     /translation="MTQNVCQQNITYTVKERFASYILEAQANQEVHLNFTLLANRFGI
                     SDRHLKHVLKQLIFQRIIERICFKTCRIADLDALTQLSVNN"
     gene            27606..28220
                     /locus_tag="VHC05_000552"
     CDS             27606..28220
                     /locus_tag="VHC05_000552"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880416.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HEQ5401887.1"
                     /translation="MSAQDKLIKPSHLITMDDIIREGNPTLRAVAKEVSLPLCDEDIL
                     LGEKMMQFLKHSQDPVMAEKLGLRAGVGLAAPQIDVSKRIIAVLVPNLPDKEGNPPKE
                     AYSWQEVLYNPKIVSHSVQDAALSDGEGCLSVDRVVEGYVVRHARVTVDYYDKEGQQH
                     RIKLKGYNAIVVQHEIDHINGVLFYDRINAKNPFETKEELLILD"
     gene            complement(28254..28796)
                     /locus_tag="VHC05_000553"
     CDS             complement(28254..28796)
                     /locus_tag="VHC05_000553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011055019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEQ5401888.1"
                     /translation="MKHILFIVGSLREGSFNHQLAAQAQKALEHQAVVAYLNWKDVPV
                     LNQDIEANAPLPVVDARQAVQSADAIWIFTPVYNFSIPGSVKNLLDWLSRALDLSDPT
                     GPSAIGGKVVTVSSVANGGHDQVFDQFKALLPFIRTSVAGEFTKATVNPDAWGTGRLE
                     ISKETKANLLSQAEALLAAI"
     gene            complement(28926..29354)
                     /locus_tag="VHC05_000554"
     CDS             complement(28926..29354)
                     /locus_tag="VHC05_000554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEQ5401889.1"
                     /translation="MSHLDKNTALKAMVVFRKAQRTLDAFGADIFKKADLTATQFSVL
                     EVLYTKGCMRINHLIDSLLATSGNMTVVLNNMERNGWISKCKDKTDKRAYVVTLTDKG
                     TRLIEAVLPKHVARVEEAFAVLTEKEQLCLIELLKKFKQL"
     gene            complement(29464..33861)
                     /locus_tag="VHC05_000555"
     CDS             complement(29464..33861)
                     /locus_tag="VHC05_000555"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PolC-type DNA polymerase III"
                     /protein_id="HEQ5401890.1"
                     /translation="MSDLFAKLMDQIEMPLDMRRSSAFSSADIIEVKVHSVSRLWEFH
                     FAFAAVLPIATYRELHDRLIRTFEAADIKVTFDIQAAQVDYSDDLLQAYYQEAFEHAP
                     CNSASFKSSFSKLKVTYEDDKLIIAAPGFVNNDHFRNNHLPNLVKQFEAFGFGTLTID
                     MVSDQEMTEHLTKDFVSSRQALVKKAVQDNLEAQKSLEAMMPPVEEATPAPKFDYKER
                     AAKRQAGFEKATITPMIEIETEENRIVFEGMVFDVERKTTRTGRHIINFKMTDYTSSF
                     ALQKWAKDDEELRKFDMIAKGAWLRVQGNIETNPFTKSLTMNVQQVKEIVHHERKDLM
                     PEGQKRVELHAHTNMSTMDALPTVESLIDTAAKWGHKAVAITDHANVQSFPHGYHRAR
                     KAGIKAIFGLEANIVEDKVPISYDPVDMDLHEATYVVFDVETTGLSAMNNDLIQIAAS
                     KMFKGNIVEQFDEFIDPGHPLSAFTTELTGITDKHLQGAKPLVTVLKAFQDFCKDSIL
                     VAHNASFDVGFMNANYERHDLPKITQPVIDTLEFARNLYPEYKRHGLGPLTKRFQVSL
                     DHHHMANYDAEATGRLLFIFLKDAREKHGIKNLLQLNTDLVAEDSYKKARIKHATIYV
                     QNQVGLKNMFKLVSLSNIKYFEGVPRIPRTVLDAHREGLLLGTACSDGEVFDAVLTKG
                     IDAAVDLAKYYDFIEIMPPAIYQPLVVRELIKDQAGIEQVIRDLIEVGKRANKLVLAT
                     GNVHYLEPEEEIYREIIVRSLGQGAMINRTIGRGEGAQPAPLPKAHFRTTNEMLDEFA
                     FLGKDLAYQVVVENTQDFADRIEEVEVVKGDLYTPYIDKAEETVAELTYQKAFEIYGN
                     PLPDIIDLRIEKELTSILGNGFAVIYLASQMLVNRSNERGYLVGSRGSVGSSFVATMI
                     GITEVNPMPPHYVCPSCQHSEFITDGSVGSGYDLPNKPCPKCGTPYQKDGQDIPFETF
                     LGFDGDKVPDIDLNFSGDDQPSAHLDVRDIFGAEYAFRAGTVGTVAEKTAYGFVKGYE
                     RDYGKFYRDAEVDRLAAGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTAS
                     WQTTHFNFHDIDENVLKLDILGHDDPTMIRKLQDLSGIDPITIPADDPGVMALFSGTE
                     VLGVTPEQIGTPTGMLGIPEFGTNFVRGMVNETHPTTFAELLQLSGLSHGTDVWLGNA
                     QDLIKEGIATLKTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGY
                     IDAMRENNVPDWYIESCGKIKYMFPKAHAAAYVLMALRVAYFKVHHPIMYYCAYFSIR
                     AKAFELKTMSGGLDAVKARMEDITIKRKNNEATNVENDLFTTLEIVNEMLERGFKFGK
                     LDLYKSDAIEFQIKGDTLIPPFIALEGLGENVAKQIVKARQEGEFLSKMELRKRGGAS
                     STLVEKMDEMGILGNMPEDNQLSLFDDFF"
     gene            complement(34115..35971)
                     /locus_tag="VHC05_000556"
     CDS             complement(34115..35971)
                     /locus_tag="VHC05_000556"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015898574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HEQ5401891.1"
                     /translation="MKQSKLLIPTLREMPSDAQVISHALMVRAGYVRQVSAGIYAYLP
                     LANRTIEKFKTIMREEFEKIGAVEMLAPALLTADLWRESGRYETYGEDLYKLKNRDNS
                     DFILGPTHEETFTTLVRDAVKSYKQLPLNLYQIQSKYRDEKRPRNGLLRTREFIMKDG
                     YSFHHNYEDLDVTYEDYRQAYEAIFTRAGLDFKGIIGDGGAMGGKDSQEFMAITPART
                     DLDRWVVLDKSIASMDDIPKEVLEEIKAELAAWMISGEDTIAYSTESSYAANLEMATN
                     EYKPSSKVAAEDALAEVETPHCKTIDEVAAFLSVDETQTIKTLLFVADNEPVVALLVG
                     NDHINTVKLKNYLAADFLEPASEEEARAFFGAGFGSLGPVNLAQGSRIVADRKVQNLT
                     NAVAGANKDGFHVTGVNPGRDFQAEYVDIREVKEGEMSPDGHGVLQFARGIEVGHIFK
                     LGTRYSDSMGATILDENGRTVPIVMGCYGIGVSRILSAVIEQHARLFVNKTPKGDYRY
                     AWGINFPKELAPFDVHLITVNVKDQVAQDLTAKLEADLMAKGYDVLTDDRNERVGSKF
                     SDSDLIGLPIRVTVGKKAAEGIVEIKIKATGDSIEVNAENLIETLEILTKEH"
     gene            complement(36169..37428)
                     /gene="rseP"
                     /locus_tag="VHC05_000557"
     CDS             complement(36169..37428)
                     /gene="rseP"
                     /locus_tag="VHC05_000557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011055022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RIP metalloprotease RseP"
                     /protein_id="HEQ5401892.1"
                     /translation="MLGIITFIIIFGILVIVHEFGHFYFAKKSGILVREFAIGMGPKI
                     FSHVDQGGTLYTLRMLPLGGYVRMAGWGDDKTEIKTGTPASLTLNEQGFVKRINLSQS
                     KLDPTSLPMHVTGYDLEDQLSITGLVLEETKTYKVAHDATIVEEDGTEIRIAPLDVQY
                     QNASIGGRLITNFAGPMNNFILGIVVFILLVFLQGGMPDFSSNHVRVQENGAAAKAGL
                     RDNDQIVAINGYKVTSWNDLTEAVDLATRDLGPSQTIKVTYKSHQRLKTVAVKPQKHA
                     KTYTIGVKASLKTGFKDKLLGGLELAWSGAFTILNTLKGLITGFSLNKLGGPVAMYDM
                     SNQAAQNGLESVLSLMAMLSINLGIFNLIPIPALDGGKILMNIIEAIRRKPIKQETEA
                     YITLAGVAIMVVLMIAVTWNDIMRVFF"
     gene            complement(37501..38295)
                     /locus_tag="VHC05_000558"
     CDS             complement(37501..38295)
                     /locus_tag="VHC05_000558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002275264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="HEQ5401893.1"
                     /translation="MKERVVWGGVAVAIFLPFLIIGNLPFQLFVGVLAMIGVSELLKM
                     KRLEVFSFEGVFAMLAAFVLAVPMDHYLTFLPIDANVAFYSLMVFFILAGTVLNSRAY
                     SFDDAAFPIATSFYVGIGFQHLINARLSGIDKVFLALFIVWATDIGAYLIGRQFGRRK
                     LLPTVSPNKTIEGSLGGIACAVLVSFIFMMIDRSVYAPHHFLTMLVLVALFSIFAQFG
                     DLVESALKRHFGVKDSGKLIPGHGGILDRFDSMIFVFPIMHLFGLF"
     gene            complement(38308..39057)
                     /locus_tag="VHC05_000559"
     CDS             complement(38308..39057)
                     /locus_tag="VHC05_000559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenyl transferase"
                     /protein_id="HEQ5401894.1"
                     /translation="MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKA
                     GMDALQEVTITASELGVKVLTVYAFSTENWSRPQDEVSFIMNLPVTFFDKYVPVLHEN
                     NVKIQMIGETSRLPEDTLAALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQD
                     VLDAKLNPGDITEDLIANYLMTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFY
                     FTPVLWPDFKKAELLKAIADYNRRQRRFGKV"
     gene            complement(39276..39635)
                     /gene="yajC"
                     /locus_tag="VHC05_000560"
     CDS             complement(39276..39635)
                     /gene="yajC"
                     /locus_tag="VHC05_000560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HEQ5401895.1"
                     /translation="MGFPTILMFVVMLGLIWFMQRQQKKQAQERQNQLNAIEKGDEVV
                     TIGGMFAIVDEVDTTAKKIVLDVDGVFLTFELSAIKRIVTKATTETTLVETEETSVVN
                     EPAVETVDSTDSAIESH"
     gene            complement(39751..40098)
                     /locus_tag="VHC05_000561"
     CDS             complement(39751..40098)
                     /locus_tag="VHC05_000561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011529027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol reductase thioredoxin"
                     /protein_id="HEQ5401896.1"
                     /translation="MTFEEIVANFIPSSVAEVTSAIASGKDMIVFLGRSSCPYCRRFA
                     PKLAQVATDNQKDVYFVDSENAADAAELAAFRENYQLVTVPALLVSYDQHQRAVCDSS
                     LTPDDILAFLTRE"
     gene            complement(40240..43737)
                     /locus_tag="VHC05_000562"
     CDS             complement(40240..43737)
                     /locus_tag="VHC05_000562"
                     /EC_number="3.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pullulanase"
                     /protein_id="HEQ5401897.1"
                     /translation="MKKKVNQGSKRYQHLLKKWGIGFVIAATGTVMLGCTPSILTHQV
                     AAKTIVGLARDEAQQGDGNAKSGDGFQSSSKEAKPVLDSSSANPASIAEHHLRMHFKT
                     LPAGESLGSLGLWVWGDVDQPSKDWPNGAITMTKAKKDDYGYYLDVPLAAKHRQQVSY
                     LINNKAGENLSKDQHISLLTPKMNEVWTDENYHAHAYRPLKKGYLRINYHNQSGHYDN
                     LAVWTFKDVKNPTTDWPNGLDLSHKGPYGAYVDVPLKEGANEIGFLILDKSKTGDAIK
                     VQPKDYLFKELDNHTQVFVKDTDPKVYNNPYYIDQVSLKGAEQTTPNEIKAIFTTLDG
                     LDEDAVKQNIKITDKAGKTVAIDELTLDKDKSVMTLKGDFKAQGAVYTVTFGEVSQVA
                     RQSWQLKDKLYAYDGELGATLAKDGSVDLALWSPSADTVKVVVYDKQDQTKVVGQADL
                     TKSDKGVWRAHLTSDSVKGISDYTGYYYLYEITRGQEKVMVLDPYAKSLAAWNDATAT
                     DDIKTAKAAFIDPSKLGPTGLDFAKINNFKKREDAIIYEAHVRDFTSDKALEGKLTHP
                     FGTFSAFVEQLDYLKDLGVTHVQLLPVLSYFYANELDKSRSTAYTSSDNNYNWGYDPQ
                     HYFALSGMYSVNPNDPALRIAELKNLVNEIHKRGMGVIFDVVYNHTARTYLFEDLEPN
                     YYHFMNADGTARESFGGGRLGTTHAMSRRILVDSIAYLTREFKVDGFRFDMMGDHDAA
                     AIEQAFKAAKAINPNTIMIGEGWRTYQGDEGKKEIAADQDWMKATNTVGVFSDDIRNT
                     LKSGFPNEGTAAFITGGAKNLEGLFKTIKAQPSNFEADAPGDVVQYIAAHDNLTLHDV
                     IAKSINKDPKVAEEEIHKRIRLGNTMILTAQGTAFIHSGQEYGRTKQLLNPDYRTKVS
                     DDKVPNKATLIDAVAKYPYFIHDSYDSSDAVNHFDWAKATDSIAHPISNQTKAYTQGL
                     IALRRSTDAFTKATKAEVDRDVTLITQAGQDVIQQEDLIMGYQTVASNGDRYAVFVNA
                     DNKTRKVVLPQAYRYLLGAQVLADAEQAGVTAIAKPKGVQFTKEGLTIDSLTALVLKV
                     SSKPADPSQKKSQTGNHQTKTPDGSKDLDKSLMTRPKRAQTNQKLPKTGEASSKGLLA
                     AGVALLLLAISLLMKRPKD"
     gene            complement(43935..45548)
                     /locus_tag="VHC05_000563"
     CDS             complement(43935..45548)
                     /locus_tag="VHC05_000563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="HEQ5401898.1"
                     /translation="MKKHWWHKATIYQIYPRSFKDTSGNGIGDLKGITSQLDYLQKLG
                     ITAIWLSPVYQSPMDDNGYDISDYEAIADVFGDMADMDELLAAANERGIKIIMDLVVN
                     HTSDEHAWFVEARENPNSPERDFYIWRDEPNDLTSIFSGSAWEYDNASGQYYLHLFSK
                     RQPDLNWENEALRHKIYDMMNFWIAKGIGGFRMDVIDLIGKVPDLEITGNGPRLHDYL
                     KEMNQVTFGNHDVMTVGETWGATPEIARQYSRPENKELSMVFQFEHVGLQHKPDAPKW
                     DYAKELDVPALKTIFSKWQTELKLGEGWNSLFWNNHDLPRVLSIWGNDSTYREKSAKA
                     LAILLHLMRGTPYIYQGEEIGMTNYPFKDLTEVNDIESLNYAKEAMGNGVSAARVMDS
                     IRKVGRDNARTPMQWSKDTHAGFSEAKETWLPVNPNYQDINVADALADPDSIFYTYQK
                     LIALRKEQDWLVEADYHLLPTADKVFAYQRQLGEETYVIVVNVSDEEQVFATDLAGAQ
                     VIIANTDVDTVLKTKHLQPWDAFCLKLKA"
     gene            complement(45678..46811)
                     /gene="ugpC"
                     /locus_tag="VHC05_000564"
     CDS             complement(45678..46811)
                     /gene="ugpC"
                     /locus_tag="VHC05_000564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sn-glycerol-3-phosphate ABC transporter
                     ATP-binding protein UgpC"
                     /protein_id="HEQ5401899.1"
                     /translation="MVELNLNHIYKKYPNTTHYAVEDFDLDIKDKEFIVFVGPSGCGK
                     STTLRMIAGLEDISEGELKIGGEVVNDKSPKDRDIAMVFQNYALYPHMTVYDNMAFGL
                     KLRKYKKDDIDRRVKEAAQILGLTEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMD
                     EPLSNLDAKLRVSMRAEIAKIHRRIGSTTIYVTHDQTEAMTLADRIVIMSATKNPQGN
                     GTIGKIEQVGSPQELYNLPANKFVAGFIGSPAMNFFEVEVKDGRIVSEDGLAIAIPEG
                     QAKMLEAAGYKGKKVTFGIRPEDISSRQIVHDTYPSATVTAEVLVSELLGSETMLYVK
                     LGQTEFASRVDARDFHSPGEQVSLTFNVAKGHFFDRDTEQAIR"
     gene            complement(46913..47056)
                     /locus_tag="VHC05_000565"
     CDS             complement(46913..47056)
                     /locus_tag="VHC05_000565"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401900.1"
                     /translation="MIDRSACFGSCDWPVFTWFSWFMVPYDLTSPAIVQVAQRSLVAL
                     SLF"
     gene            complement(47109..47957)
                     /locus_tag="VHC05_000566"
     CDS             complement(47109..47957)
                     /locus_tag="VHC05_000566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011055028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PucR family transcriptional regulator"
                     /protein_id="HEQ5401901.1"
                     /translation="MELKDYFPEMQVGPHPLGDKEWVSVKEGDQYVHFPKSCLSEKER
                     LLLEVGLGQCEVLQPLGSPWQRYLLDHQGNPPQLFETSQFIYLNHQQVLPADLVELLQ
                     QMIAGLEVILPISTTQTAFLCRQATSIKVLRSLEGLLPTLESDFGLALTMFVGNAWYQ
                     VAAGTLRECFEEECQLLTAYLRQQSGRKLLTFSGLMLWSLLSHHTFLALTRQFHQFLS
                     PQSDMADVVHALWSEHGNLVQTAQRLYIHRNSLQYKLDKFAQQSGLHLKQLDDLAFAH
                     LFLLKY"
BASE COUNT        14301 a        10468 c         8834 g        14573 t
ORIGIN      
        1 aaagtattcg taaaactgat gttgctgata ctctaacttt aattcatttc tttttatcat
       61 tttttcctac cactacttaa aaatcctgcc tagactaagt ctaaacagga aattttagtc
      121 tgcttatcca gattgtttta attaacaaca aacaaatact gagttcggac agtcatcagt
      181 aatagttgca aaccaacctg aacctttttt accaccagct acttccataa gttctttttc
      241 agaaacttct tcgatagcat tagtcaaaat atcctttgaa tttttcataa aactcattct
      301 ccttcctatc agtatgtagt gactattttc tacactttta ttgtaaataa tacgtcttca
      361 ttttcaatga gtaaaaagtg caaaaatgac ttttttcata ttttttagta agatttttga
      421 gatgtcacat aagaggtcac tttataacaa atagccctct gatataaaaa acaaaactcg
      481 ttctttacag ctattttaca atctaatcgc ttctcgttat aacatcaatc tctaatcaga
      541 aaatggttac tttacttatt taatcaggtc aggagtttga atgacagaag tcaaatatct
      601 gaaaaaggat gttaaataaa actttcaaaa cccattttca tcaactaaaa acacttataa
      661 cccgatctta caactaatgg attaccatca acagcaaata atactatgct tgaaaaatgt
      721 caacatcatc tactttttgt gactataatt cagtaaacga acatgacgtg taaaaatgta
      781 ttaaagcagt atctcaaaat cattcaatca cttgagtttc tgctactttt ttataccagt
      841 aggcactctt cttaggataa cgttcttgag tttcaaaatc aacatagaag agaccgtaaa
      901 gtttttcata gccatttgac catgaaaaga catccatcag tgaccacata aagtatcctt
      961 taacatttgc accatcagaa atagcatcag aaataacttc taagtgtttt ttcacataat
     1021 cgatacgtcc atcatcatag acagtattat ctacaaactc atctttgtag ccaagaccat
     1081 tctctgtaat gtaaattttc ttgtaattag gataatcggc tttgacacgc atgatttgat
     1141 catataagcc ttgtgggaag ataatccagt cccagtccgt ttttggaaca tcaacgggtg
     1201 cttttcttcg accaacaccc ttgatttggt atttagagct gcctttttca cccttaccat
     1261 tgtgaatgat ttcagtctca ccatcaaaag cttgcatcca atcactcata tagtagttaa
     1321 taccaaggaa gtcattcaaa tcttttgcag catccagtgc tacaaagtct tcttcacgaa
     1381 gatcaagttc accaccattc acctcaagga tatggttaac accttccatt gttttatctg
     1441 aatacttacc tagataagtt gcatcaagaa taaatttatt atggatgata tcttccagtt
     1501 cagctgctct aacatcatca ggattgttag cgtcaaatgg atacttagtt ggaagagcat
     1561 ggacaacacc aatttcacct gaatagccac catctttaaa gagtttcaca gcgcgagcat
     1621 gagaaaccat catgttatgg tgtgattgga aaactttagc aagatcatat tgaatacctg
     1681 gagggaattt accaactaag tattggccat caccaattgg tccaatttcg ttaaatgttg
     1741 tccaatagtt aacttctgag aattctttaa aacagaattc tgcataattt acaaaatgtt
     1801 caatgttctc acgattgagg aaatcaccat ccgagtggag agcttctggt gtatcaaaat
     1861 ggtgaagtgt aacaaaaggc tcaacatgac gcttatgaca ctctgcaaag agattgtggt
     1921 agtattcaac tcctttaggg ttaacgtctc cttttcctgt tggaaaaata cgagaccaag
     1981 caatagagat acggatgccg ttgacaccaa attcttcact aagtttcaaa tcgactggat
     2041 aacgattgta aaaatcactt gctggttcag cagtgtacca atagttgtct tctaagtatt
     2101 tatcccaagc tactggtcct ttgccatctg tatgggtagc accttcagcc tggtaagcag
     2161 ctgtagcacc accaaaaata aaatctttag gtaatgtttt tgtcatctca gtttctcctt
     2221 gaatatcttt caaaaataaa gttcccaaaa caatttttgt gtttgagaac tttacgacat
     2281 ttaaactgtt ttcttaattt tcaaactgtg cttttacaaa atcaagagct ccttgaccat
     2341 cacgggtcaa tttgatgtat tgagcccctt ctgttttagc taatttaata tcaagtttat
     2401 cagtttccac tttcatatct tcatagttag aagctacttg aggtgcaagg ataacaagtt
     2461 gatattgtgg taaaatctca cggtgagcac cataacttcc tgctgctgca gtgacaggtg
     2521 caccatattc tttagctgct ttattcaaag catttgctag tagtccactt gtaccaccac
     2581 cggcacaaag aacgagaaca ttagtttgat cagtgatttc tttggtttct ttagctgctg
     2641 atttttcaag aatagcatca gcttttttag tatcaaagtt tgctgctact ttttctttga
     2701 gggcatctga tgaattcgta cctgctgctt cttcagtaag aatttgctca tcatatactt
     2761 ttaagaatgg gtagtagatg atcacatcaa cgacaattaa caaagctgcc aaaatgaatg
     2821 ctagcacttg gaagtttgtc ccaaggataa gacccaatgg agctggtgtt gtccaaggta
     2881 agtttgcagt gaaactgttc attccaagtg tgtcaatgaa gaatttgaaa atccatacgt
     2941 tgacaatcgg tgccaagata aatggaataa agaaaattgg gttcaaaaca agtggggcac
     3001 cgaacaagat aggttcgtta acaccaaaga atgttggaac aacagatgca cgtccaatgg
     3061 ctttgttacg ttttgatttt gttaaccaca tgaacatgaa tggaacgacg agagttgcac
     3121 cagtaccacc catggtaacg atgaacattt gagtccctga agtcaaaatc ttgtcagcat
     3181 gttcaccagc ttgaagtaat tgaaggttgg tttcagcatt tgcgtaagta atcgctgcaa
     3241 tggctggttc aacaatagat ggtccatgaa taccaacaaa ccagaagaaa gcaaatgcac
     3301 cgaagataat agtgattcca acataaccat ctgctgcttg gaacaatggt gcaagaagtt
     3361 taccaattga ctcggcaacg ttaacgccta aagtagtatg aacaatcaat tcaatcacat
     3421 aaagcagtac aactgataac gtaaatggaa tcaaatcttt aaaaacttga gatatatttg
     3481 gtggaacctc ttctggcatg cgaatagtaa cattgttttt cacacaggtt ttatagacat
     3541 ttacggtaat aaaagctgcg atgaaggctg tcaacaaacc ttttgttccc ataaatccag
     3601 ttaagaaacc accgtctttt gctggattgg ctgccataag taaaaaacct acaatagcag
     3661 cgagcatggt agacatgaag ttgatttggt ttgtgcttgg taatgatcga ttcattgagt
     3721 cagttaaagc tttggctgtc gtaccagcca caaacaaacc taaaataccc attgagtagt
     3781 tgtatggcgt catcaagaga ttctcaatat ccttactcca atggaagccc catgcatttg
     3841 gaacataggc aatcaagata aagatacttg aaaacaagat aactggcata ccagtgataa
     3901 aaccatcacg aatagcgcga aaatagatgt ttcgagaaat tttctcgaag aaaggtttcc
     3961 ctttctcaat ctgagcaatt aacccattca ttattttgct cctctcttat aaagttcaat
     4021 catgtgtttc attaaatctt gtaataaaat ggtcgtcatt aaatgatctt gaccatgcat
     4081 taaagtgaca ctataagcta agtcatctcc agctgcttct ttttgtagta gacttgtctg
     4141 agcattgtga gcatcattca agcagtcact acctgcagcg attaattctt ctgctttagc
     4201 ataatctcct tcttgcgctg ctttaagcgc ttccaaaaat tttgaacggg catcaccagc
     4261 ataggctacg atttcaaaac ctaaaagagt agtttcttct ctattcattg tagtttcctc
     4321 cgaaaataat gttacatttt ttcagtccaa ggacttgcag ttttatctag tactttgttt
     4381 aattcgtcaa tatttttgaa accttctgta cgcaaccatt cacgagctgc ttgtggtcct
     4441 tcttcgatat agacttttac agatcctgcc caggtagcac gtccacataa gacaccgttg
     4501 aatttagcac ctgattctgc tgcaaattcc aaagtatctt ggaacaactt ggctgaaaca
     4561 cctgcactca agtaaatata tggtaaatca gtagaagctt cttgatcacg gaaagcttga
     4621 gctgcttctt cttttgtaaa gagaacctca ccatctgcaa agccttctac aaatttcata
     4681 tttactggaa cttcaacttt caacacgtca acaccaaagc gctcttttga gaaaactttc
     4741 attgcttcgt taactttatg agctttaact tttgcaaact cagggcttgc attgtcagca
     4801 attttctcat cataagttag aatttctaag tagaatggaa tatcttctgc acggcattca
     4861 gaaccaatac gttcaatgta agcttttttc tgctcgttaa catcttgatc tccatcaata
     4921 tcatagtaaa gaaggaattt aactgcttct gctccagctt ctttaatacg ttttgcagac
     4981 caaacatcta agcaatcagg taagcgacta gttgttgttg catcgtatcc tgttttctca
     5041 tatgccaaca acaagcctgc ttcttctgaa cgaacacgac ttgctggcaa gccatattca
     5101 ggatcaagta aaattgatga tgcaaatggt gtcagttctt cagaaactaa acttttaagc
     5161 tcttcaattt gttctactgt tggctctttt gtttgatgtt gagccatcat acgtttgaga
     5221 gctccacgtt ggtcaaaagc taaagcagaa ataacaccat ctatacttag tttttccatg
     5281 cttttacgtt tgttttcagt taaagtaatt gtcatttttt atacctcttt gactttaata
     5341 gattgatata gcttatcgta atttgccatg ttaacatgcc cagttgtttt ttcttgcgca
     5401 tttaacatcc ctaagacatt tgcttttgtt aataaagctc gatcatcttc atcattcgct
     5461 aaacctgaag caatacctgc tactgtagaa tcaccagaac ctacagcgct tacaatttcg
     5521 attttaggga tgtcaacgtt ataaaacgta tcattgtgct ttgcaaatac accatcagca
     5581 ccaagagaaa cgattatcca ttcaattcct tcaaatagtt catcttgtaa gacttctttt
     5641 aaagcttcaa aatcttttgt catttcttta cctagaagtt gagaaagttc ttcaagatta
     5701 ggtttgataa ctgttggttt actatcacct tttagtactg cttctagagc atttccagaa
     5761 caatccagaa ccgttttctt accattaaga ttggcaatac cgattaactt ctgatagtaa
     5821 tcatctggca taccagcagg caaactgcct gagagcgtca ctacgtcaac atcattcagt
     5881 aaatatttaa aatgatgagt aaatccatca atttcctcta cacttaacag cggtcctttt
     5941 tctaaaatct ccgtttgatt accttcgtgt aaaatggcta tacaagttct agtatcacct
     6001 gaaattttat agaagcgact taaaatcgaa tcaggaagat gattaataat aaaatcaccg
     6061 ctttctccgc caatacaacc agtagctttg actgtctcac caaaatcatt tagaactctg
     6121 caaacattca agcctttatc accgggtgtc tttgtaacgt ctacaactcg gtttacagta
     6181 tcgcatttta gctcatccaa agggtaggag acgtcaatag ctggatttaa agtaactgtt
     6241 aaaatcacaa tagctccttt ttctctatat atccctatag taatttattc aaatattagt
     6301 cgtgatattc accacggacc catttttcta gaaattcatc aaagaagtgt gggttgtttt
     6361 gatcttgact agcatgttgc aagctatcca ttttttcaat ccatttttta ttttcttcag
     6421 ttggtttgta ttccgcggct aagaaagcat cgataatatc attcatcaat aaaccaccga
     6481 taatttttcc accaaaacca ataacgtttg cgtttagctc ttcttttgag tagatagcag
     6541 atgtcatatc tctaacgagt gctgcacgaa taccgggaac tttgtttaca gcatttgtga
     6601 taccaacacc agtaccacag ataacaacac ctaattctgc ttcaccactt gctactgctt
     6661 caccaacttt tttaccaaag attggatagt gtgtgcggac attatcgtat gtcccgcaat
     6721 caataatttc atgaccttgt gttttcaaat agtcaacaac agcgattttt tcataagtaa
     6781 caatatggtc acaacctaca gcaattttca tttttgttct ccttgtttta acctatttca
     6841 atcaattagc acattttatt aagcatgtcg acacgaactt gatgacgtcc accatcatat
     6901 ttaccttcga caaagccttt gataatgttc tttgcaattc ctggagcact aatttcagaa
     6961 ccaagcgtga tgattcgaga gttattgtga cctcttgtca tgtatgctga gcgctcatct
     7021 gatacttcag ctgccaccat tcctttgatt ttagtagcta ccatgaaaga accaacacca
     7081 tatgcatcaa tgacaatacc taagttatct tcagatgcat taacttcttt tgcaacggct
     7141 aaagttgtat ctacaaagtc acgtacttcg ttttcactaa catcaacgac ttcgtattta
     7201 ccttctttaa ggtaatcttt gataacttct ttaagttctt gacctgcttt gtcagcaccg
     7261 ataataattg ccattttatt tctcctataa tttagaataa gtaaatgtgg aaaacttacg
     7321 tagatagtta attaacgatt tgcaaaatct tttgaaataa cgctttcatt atttctatga
     7381 cctaatcata cacccaccaa acataaaagt caacattttt ttgtttattc ttataaaaaa
     7441 taaacaaaat atgtttattt ttttcatttt tacgttatta tcctaatatt tcttgtgttt
     7501 ctttttcatt tcataaatcc ctttgacagc cactcgtaac ctatcctata ttacgaaacc
     7561 cttatctcta tttattgtaa acgttttatt taaaacgttt tctattttgt taatttttgt
     7621 tttttccaac atttatgttt gttttgtttg atttttttat tgatattatg ttatgatacc
     7681 tttaatagtt ataccctaag acactgatag gagataagaa tgaaaaagaa agagcgtcat
     7741 gaaaaaattc tcgatatctt aaaagttgac ggttttataa aagtaaaaga tattatcgat
     7801 gaaatgaaca tctcagatat gaccgctaga cgagatctcg atacattggc agataaagga
     7861 ttacttatca ggacccatgg tggtgctcaa tatttggatt attcttcagc aaaggacgaa
     7921 ggtcacgaga aaacacacac tgaaaagaag gtcttacaga ctaccgaaaa aaaacaaatt
     7981 gcacaaagag ctaaaaacat tattaaagat ggcgaaactg tctttatagg tccagggaca
     8041 acattagagc atctagctgt cgaattgaaa aatagaaata tcagggtcat tacaaatagc
     8101 cttcctgttt ttttaatttt gcacccgagc actactattg atttgatttt aattggtggt
     8161 gaatgtcgtg aaattactgg agcttttgtt ggtgctattg ccattaataa tctagaatca
     8221 ttaacttttt caaaggcttt tgttagcgca aatgcagttt acaataattc tattgcgacg
     8281 tacagtgatc tcgaaggaga agttcaaagg gttgcattga ataatgctgt tgagaaaatc
     8341 cttctagttg atagtaccaa gtttgaaagt tatgacttct ataatttcta ccaactagat
     8401 caagtggact taattgtgac tgataaaaat gtgacaactg gtatcataga aaagtacaag
     8461 aaattctcaa aaatcataat cgctgacaag taaaggacct actcatatta aaaagcactt
     8521 cagggtttag atatatcccc tgtcaagtaa acagggagca tatctgaaag tagtgtttgt
     8581 attataaaga agtttcttgc taacttattt tctggttttt ttcagactta tcagtcttgt
     8641 actgttcctt tttctgatga ataacgtgga aataggcaga cagctatata tttcacctct
     8701 agaatggttg ccattactgt catcaagaca tgcttgttct ttatcgtatg gagtaaagct
     8761 ttcttttagc catcaacata cctcttaagt agattttggt tcgttaccat gtctacttaa
     8821 gaggtgtctt caaagcgctt taaaacgttg atataacagt atattaacgt tttgagaatt
     8881 gtgaagcttt acgagctttt ttaagacctg gtttttggtt cactccatta tttaaagtca
     8941 aatcccttta aaatcaatgt ttctaaaatg aaaaatcact aaaaatctta tttatagaca
     9001 aatacttaaa cctaaacggt atcaaaaata agtttcggag cttatcaaat aatgaaaatc
     9061 tgtctcaatt accgagtctt ttttattgac ttttttgtat atatgatata attaaataaa
     9121 ttacataaag gggttacata aaatgactac agtaaaaaaa aacagagcgg ttacctttca
     9181 agctaataaa gaattggtaa gcgaagcaat gacagtatta aacaaaaaaa atttaacctt
     9241 atcatctgct ttaagattat tcctacaaaa tgtcgttgtc acaaacgagg ttgacttatt
     9301 gacggaagag gagttagaga aagaaaaact tttcaagcaa tttcaagctg aaatcaacaa
     9361 aaatattgag gacgttcgtc aagggaagtt ttatacctct gaagaagtga gggctgaact
     9421 tggactataa gaaatatcag attatctatg ctcctgatgt tttagagaag ctaaaagaaa
     9481 ttcgtgatta tatttctcaa aactactcct caacatcagg tcagcgtaaa atggagcaaa
     9541 tcattagcga catagaaaaa ctcgaggttt tcccagaagt tggttttgat gccgatgaaa
     9601 aatatggttc aaaaatcagc cattatcaca gcactaaagg ttacacctta agtaaagatt
     9661 atattgtcct ataccatatc gagggggaag aaaatagggt cgctattgat tacttgcttc
     9721 ctactcaaag cgactatata aagttattca aataacacgt taaaagcctt agcagtcttg
     9781 ctagggcttt tttggtagat taccaattaa ctaggagcaa aatgagttcg ggctggttaa
     9841 tagatattcc acaaagaagc caaagactac gaagctaggc taatctacct taaggcttca
     9901 ggcataccca tgcaaccctg atgattgaga ttggagttga cccagtaaat acagccaaaa
     9961 gactaggaca tgctagtagt caaatgactc ttgatacata cagtcatgct actgcagtcg
    10021 gagaggacaa atcaatcaaa caatttgcta actatctcaa aaataactaa ataaacgtat
    10081 taaaccaagt caaaagtttt ccgaaacggt atcaaaaaag gtatcaaaag caaaaaacga
    10141 caaaaaagca ccttgcaaga gacttgcaaa atgcttgtaa tcgttgatgt aaagctgttc
    10201 ttaacgtttt gagaattgtg aagctttacg agctttctta agacctggtt ttttacgttc
    10261 aaccatacgt gcgtcacgtg taagaaggcc agcgcgtttc aatgaatcgc ggaagtctgg
    10321 gtctacttga agaagcgcac gagcgatacc atgacggatc gcacctgatt gtccaccgta
    10381 accaccacca acaacgttaa cgaaaacgtc gtatgaacct tcagttgatg taactgcaaa
    10441 aggttggttg atgatcaaac gtaggtcagc atgtgggatg tattcttcta catctttttt
    10501 gttaacagtg attttaccag tacctggaac caaacgaacg cgtgcaacag cgtttttacg
    10561 acgaccagta cctgcatatt gtgcttgtgc cattatttaa tgctcctttc ctcttagata
    10621 agtcctgaga tgtcaagtac ttctggttgt tgtgctgcgt gagtgtgctc accgccaacg
    10681 aagactttca atttcatacc ttgtgcacgt ccaagagtgt tatgtggaag catgccttta
    10741 actgattttt caatcaagcg aactgcgttt ttagagcgaa gttcaccagc agtgattgat
    10801 ttcaaaccac ctgggtacat tgagtgagtg tagtaaactt tatcagtcgc ttttttacca
    10861 gttaatttaa ctttttcagc gttgataacg ataacaaaat cacctgtatc agtgtgtggt
    10921 gtgaaagttg gtttgttttt tccgcgaagt acgctagcaa ctactgcaga aagacgtcca
    10981 agtggcacat cagttgcgtc aacaacgtac catttgcgtt caacttggcc tggtttagcc
    11041 atgaaagttg ttttgttcat gatttctcct atacgaattc gtaatatttg tttacaaggt
    11101 gatgggtgtt ccgtcccatc gaaggtattt ggaaggttcc ggggcctttc aaatggggta
    11161 aacaataccg cctactatga tatcaaactt aagaggctcc agtcaagtgc tttagctgat
    11221 tttattggat tattttttct ttcgtttttg aggaatggca gagctgctct gctgatgtta
    11281 atgggaatca tcagcttccc aaaaaaggtc gtctaaggtc ttatcaagca ctcgacaaat
    11341 ggcaatgcaa agattaatcg ttgggttgta atcacctttt tcaacagccg caatggtttg
    11401 tctggagacg cctaccaaat ctgctagagc ttgttgagac aaatctttgc ctgcacgcgc
    11461 tgcttttaat ttgaggttct tcattcatct gcctctttag catccagata atgacgatag
    11521 aaaatactag ctcccatact aaggagcgtt atgcccaaca ccattaaaga tccactgccg
    11581 ccagccttga aaaagcttcc cattttaagt tgccctgcca tcatctctct taccgccaaa
    11641 cctatagtga ctaaactcat tcctgttgct atcatcccca ccagtattcc ttgttttcca
    11701 aagcgcctat ccacaaatgg cgataccccg ttgaggttac aatatgtcgt ttgaactgcc
    11761 aaccctcccc aaagagccaa tgtaaagagg aagcttgcag ataccagtct ctctgagaag
    11821 cgatgaagaa agattgacag ccaaacagcc acaatcataa accaaaaccc aatagtgtat
    11881 cctttgagaa gaatctgttt ttggcgttcg tcatatctgg gcagcttctg atcgtccctt
    11941 accttagaat ctagtatttc tttgctatct agtctcgttt ggagcttttt tgctgtcttt
    12001 agcccccata ccaacaatat gagaaagcta gtcaatataa ccgctacacc tccaactaag
    12061 taacgttgaa aactggtttt agccagcagt gtcgctacta acacaaccaa atccatcact
    12121 gctgttatga ttataaacat ccattgtgac ttagcgagat tttgtttgct atcaaacatg
    12181 attcgtttct cctttaaatc tttatatgac ataatataaa ttattttaga tattttgtca
    12241 aatatatttt acattcttga ttgatttaag cagcaaaaaa ggattgagga tttctcttca
    12301 atccttataa gggattaacg ggaattctgc ccaatcacaa aaactgccag ggtgttagga
    12361 ccaacgtgag ctgagataac tggtcctagt ggcatcataa gaacatcgct aatattctca
    12421 tgcgccagca gctcttctcg caacttttcg gcactaccct gatcgcttgt ataagagaca
    12481 ataaccgtcg aatccgcaat atctttttcc acttgagcca ccatttcttt gatggctttt
    12541 tggcgtcccc gaatttttgc aatgggcacc aatttccctt cctcatcaat ccacaaaaga
    12601 ggtttgatac tggctaaact gcctagaaaa gctgaacctt ttgacagacg cccaccacgc
    12661 atcaaatgaa aaagatcatc tactaagaaa taggtgcgca gtcgaggaat cactgcttca
    12721 acaatatctt tagtctccag taaatttttg ccactatctc tggcttctgc tgctaaaatg
    12781 gttagatagc cttctcctcc tgcagcagcc aaggtatcaa caatttcaat cactgcatcg
    12841 ggataatctt ctcgaacaag atcgcgtgcc attagagcgc tttgataggt acccgataaa
    12901 accgaagaaa aagcaagata aagcagtgct ttgttgttct tagcatgttc acgaaaaacc
    12961 ttctcaaact ctcccacatt aatctgactg gtttgaggat gactgccagc tttcatcttt
    13021 ttcaaaaggt aatcactact aatacggtta ggaccgaccg tttcataaac ttctccatcg
    13081 cacaaaatcg ttaatcctat aaggacaata tcatgatctt ctgcccaggt ttgattcaaa
    13141 tcagcggttg aatctgtcat tattgtaaag gtcattctta cttctcctca tccagttttt
    13201 tagtttgaca atcaaataat tattgtttta ttttatcaaa aaaacccgca cttggcgagt
    13261 cgtaattctc attatcgatc taactgagac ataaaatcct tcagttgact aagctgtcct
    13321 tggtcaaaag gccgcagttt aggcgttttg agatcaatat ctctagacat tttatctaaa
    13381 tcagctttga cagtatgaac tctttgctct aattctcttg cagtgacacg aagagctcct
    13441 tgagaaaaaa tcgtccattg ttcatttaaa tcactcgtag ctacttctac catatgtata
    13501 gccgtattta actctgctgc catgcgctca atgtagctat ctgctgtttc gtcttcctct
    13561 gtaaatacca ctgagatata atactggtca tatcgttgcc ttaaccccgg tacatattgg
    13621 gcatcaaaaa cacaaataat attaatattc tcaaaatggg cataatgatt aagttttgtt
    13681 aaaagtgtgt tacgtgcctg atcaagctga tttgtcttaa acaactgacg ggttgattgc
    13741 caaaaggcaa tcatattata cccatctact aataatatcc gttttttcat aatttagcgc
    13801 ctatttcgga aaacttcata catgagaata gctgccgcta cgctagcatt taagctctgt
    13861 acatgaccat tcataggaat cgtaatcatt tcatcaactt gctttttgat attggtagag
    13921 atgcctttgc cttcgttacc aatgactaaa gcaagtttac cattagtgtt ccagcaatca
    13981 gacggtgttc cattcatgtc tgtgccaaaa atccagaatc ctcttgcttt caatttatct
    14041 agagtttgac taaggttagt tactctcgct atcggaatat gttcaacagc acctgtagac
    14101 gtctttgaga ccactggagt cacaccaaca gaacgatgtt taggaataat cactccacat
    14161 acatttgtag catcagctgt ccgtaaaatc gatcctaaat tatgaggatc tgtcagacca
    14221 tctaaaataa gaatcaaagg atttgcttct tgctctgcta tttcgaggat ctcatcaaca
    14281 tcagtatagg caaaagctga tactctcaga acaaaacctt gatgcacagc tccatcagtc
    14341 atttgtgaca aggttttttt aggcgtccat gaaatagcga cctttttttg tgtcgctaag
    14401 cttttgatgt tatccacttt ctttcctctt aaatcctctt ggatataaag cttatttcct
    14461 gtatttgctt gaaggctttc tgtaacggca tgaacaccat agacgatatc gtttgtttca
    14521 atagtatctt tatcttccat gagtttatta taccatgaat gcttcaaaat aaatgcatag
    14581 actcttttat tttcgtctag atactttttg aatagctata aataaacctg cagctaaact
    14641 gactactaga cctgataaga cccaagggaa tcctcttttt gaagtaggtt ttacttcctc
    14701 tttgtccact agcatttttg tcttgttgct accgtttttt tggctattac tagcagttgg
    14761 tgtaagtttc tcatttttag tagatcgctt taaggaagtt gatcgatgat tagtagctga
    14821 tttgaaagga tttgaagtag aatctatttc ttggttagct gattgatttg tttgagcttt
    14881 tgtgtctaca tcgaccgaat tcgtcattgc tttagaagta tccttttgtt gcatattagt
    14941 tggtgttttt ctagctttgt tttgatcaaa atgaacagtt cctgattgac cagttactgc
    15001 cttttcttga gtatgaacgg tgacagttac atgatagtca ccactctttt gtccagttaa
    15061 atcaaaccaa gctgtaaaac gacgctgttg cgctgccata gtatataccc aactattaat
    15121 agtattatca ctagcgtctt taagtgttat cgttgcctga gttggttgtc tgacaggttg
    15181 atctgtggtg actgtagcat caatataagg ttctgttcca cgcatactgg cttcaacact
    15241 gacctgacta atagttgatt cagctataac attatcagtg tgctgatctt gtgcatacac
    15301 agatatagct ttgccagaag tccccagcaa accaataagt aaagctagtg ataataagct
    15361 aactgttttt tgcatagttg tcataataaa tatctcctct ttaaattagt cttaccctct
    15421 cattataaac tattcgaaaa tgatttcata atttttatgt cttttttgtt acaaatgtat
    15481 cttttttata tcattatgtc tttttgatgt cataaaaaga cttaatggct ctctaccttt
    15541 acttcagatc tatgaaaata agagtctcct aggggactct tatgaggata tcaattgttg
    15601 cttttctaca tactcaatac accatctgat caattcttct aaccgctctt tttggcccat
    15661 catatccaga taacccataa tggcttcaaa acctgtcgac atacgatagg taataatatc
    15721 ggcattctta gctttagtat ggctattggt attgcgacca cgcttataga tgtcttcttc
    15781 tttttcggtc aatagctgcg cttctaacat agcctgaatc aagttggctt gtgccttagc
    15841 agaaacatac ctcgttgcta aacggtgtag ctggctaggt ttcgttttac cttgaaaaat
    15901 gagatgacga cgaacatagc aggaataaac cgcatcccct tcaaaggcta gggcaatacc
    15961 attaatcaaa ttcacatcaa ctggattagt cacgcagcca cctcacacca tctttggtat
    16021 ctagcagctt gatgccttga gctgctaact gatctcgaat ggcatcagct gtggcaaaat
    16081 cacgattcgc gcgtgcttct tgtcgcttag caatcaaggc ttcaatgtca acctcaagca
    16141 cctcttcttc aaagataatg ccaaaaacag ctaacatttt ctcaaaagcg cttttaacag
    16201 gttctgtata ggagccagaa ttaatccact tggccatgtc aaatacgacg gtaatcccat
    16261 ttgctgtatt gaaatcatcg tccatagcgt cttggaaagc tattacaaac tgttttagct
    16321 cttgctcatc tgcagtttct gtcagcggtt gttgcaaggt gtttttaaga tacttcagat
    16381 tgatttccgc atcatgaata gccttttcag tgaagttaat tggttttcgg tactgttgtg
    16441 tcgcaagaaa gaatcgcaaa acctgaccat caacggtttg taacatgtca tgaacggtca
    16501 caaaattacc tagtgacttg gacatttttt cgttatcaac agtgacaaac ccattgtgca
    16561 tccaatagtt agcaaaagtc ttgcctgttt tggcctcaga ttgggcaatt tcattggtat
    16621 gatgaggaaa ttccaaatca gctccgccac catgaatatc aatggtatca ccaagaattt
    16681 cagtagccat cacagaacat tcaatgtgcc agcctggacg accaaacccc caggggctat
    16741 cccaagaaac ctcacctgcc ttagctgatt tccaaagagc aaagtccagt ggattttctt
    16801 ttaaagctgt ctcagcatct gttcgaccac tggctccaac ttcaagttct gacagggttt
    16861 tattagctag cttggcataa tgctctgact tttccacgcg gaaatacaca tctccatctg
    16921 cttcgtaagc aaaatctttt tcaatgagac tttcaacaaa tgaaatgatt tctgctatat
    16981 aatccataac acgaggattt tgtgtggctg gcttaacacc aagtgccttg gtatcttcta
    17041 taaaagctgc aataaagcga tctgacaatt ctttgggaga aacacctgct tgagtagcag
    17101 ccttgataat tttatcatcg acatcggtaa aattggaaat gtaattgacc tggtagccag
    17161 tatactcaaa ataacgccga atggtgtcaa aagcgaccgc tgatctagca tttccaatat
    17221 gaatataatt atagaccgtc ggtccacaaa cgtacatatt gactgtattt tcagtcaaag
    17281 gtacaaactt gtggagcgaa cgggtcatgg tatcataaat tttaatcatg taaactcctt
    17341 attcaatagc ctggcattag ttgtcatctt gatatcctaa gtctttttct gaaatgctgt
    17401 tccacctttt caacaatttg atattaataa ccaaacctat taaccaaaat agggtcaaaa
    17461 tgaagtatat aatcgcttta accatgtctt gtttcagtaa aaagattaaa ctagccacca
    17521 gtgtaatact agaaacaagg atagacaaac tcataatgac atacagccca actcttattt
    17581 tattcatgag gctcctttat taacgaaaaa ccttcacaac ctgtgaaggc ttcagaaagt
    17641 agacaaaccc acttttatgc tcaaaaagca tgaatagatc tgctgatttg acatcaggtt
    17701 tcctatttct gcatgtgggg taagccaaaa cagctgcttt ttgttgtggt aaaagtggca
    17761 tcaatactga cagtgatgcc catacggatt tttgagatct taggctcaaa actaaggcat
    17821 ggaattccaa aggaagtcgc tgccgtaagc accacctgag aaaaagtatc acaaaagtcc
    17881 caaaatattt tattggaagt catcagtgct tctttttgtt attttccgat cattttgaca
    17941 actgataaga gacctctcgt tgtttttgta aactttgaat ttgacgatta tctttttgcc
    18001 catgcactcg tactatctta gctggcacac ctacaactgt cacgtcttca ggaacatctg
    18061 ataacacaac agctgctgcc cctactttag catttgctcc gatgtcaata ggtccaatca
    18121 cttgggcatg tgccgaaatt aaggcacctt gtcgaatcgt tggatgacgc ttgccacaat
    18181 cttttccggt tccacctagg gtcaccccat gataaagcat cacacctttt tcaacaattg
    18241 ctgtctctcc aataacaaga ccagcaccat ggtcaatgaa gactccagga gcgatttgtg
    18301 ctccaggatg gatttcaatt tgtgtccaaa atcgccaaaa ttggctatgc attctggcta
    18361 gtaatttaaa atgatgtcgc caaagaaaat gagacaaacg atgagcagct agggctttga
    18421 tgcctggata agttaggata acctcaagac tattacgagc agctgggtct agagctttaa
    18481 caatagctat actttctttc caccaaccca tactaactcc tacgacttat ctaattctga
    18541 ccaatcaaca agaatttgtt ggtcatcaaa aggattgatg gcgacaccga acgtttcatc
    18601 aagctcgttt tcaccatttc ttggttgata aatatcatca atcgtccaag tcagaatcac
    18661 tccttcagct ttcctgaaaa ggcctccaaa atcgtcttgg ttgtaccatt tcgcaaagct
    18721 ttgaagattt gaaaaggcgg gaacatagct ttttccttca ggcgttgaca tggtaggaaa
    18781 aaggcggtcg taatggttat catctttagg ataaacaaag gcgggaacaa ggtaaacctt
    18841 ttccatcgta tctgccgcca cattgtcatc actcataagc gtatttaaca cagtggtgta
    18901 atggttcata aattgaatca tgtcactgct tttgaaaatg gtagaattcc caaaatctcc
    18961 ctttttctta aggttaaaga caagacctgc tgcaccagat gtaatgacct cttctagcac
    19021 tgcaagagct gaacgctcca gccaatactg actttgagca ctcttttgtt cttctttaaa
    19081 gcgagccata tcttccttat cggtaaaaac aggggtaacc ttgacacctt cgacttctat
    19141 cacgtagggt tctttagcag cccagacagg aaaattatgg aaagcgttga caagggcaag
    19201 gctatccaaa aagttatcag gcgcattgat aaaagctctt aagcgaatat ctaattcatt
    19261 tgatttagtc atgtttttct tcttttttct ctggttttgg tgggcgtgga atcaaagctt
    19321 tcattgaggc atccacacga cccttctcat caatcttaat gaccttaaca tcaacgtctt
    19381 cacccacttc aaggacatct gacacgttag ctgttctcgt ccaggcaatt tcagaaatat
    19441 gaacaagtgc atctgtcttg tcaaagaggt tgacaaaggc accaaatttc tcgatacgga
    19501 taaccttggc atggtaaact tcgcctacct tggcttcacg aacaagacct gcaataattt
    19561 ctttagtgcg gtcaatggca gcttggtcac ttgagtagat agagacattt ccttcgtcgt
    19621 caatatcaat tttgacaccc gtttcggcaa taatcttatc aatagtttcg ccacctttac
    19681 cgataaccac tttgattttg tctacgtcaa tcttgatggt gtcaattttt ggtgcagttg
    19741 gggctaactc aggacgtggt tcagcgatag ttgcttcaat cacatcaaga atttcaaagc
    19801 gagctttttt agcttgtgca agagcttctt ctaggatttg aggggtaatt cctgcaatct
    19861 taatatccat ttgaagggct gtaatccctt cacgagttcc tgccacttta aagtccatat
    19921 ctccaaagtg gtcttcaaga ccttggatat cggtcaagac tgtataattc gtcccgtctg
    19981 aaatgagacc catggcaatc cctgccacag gagccttgat tggtacacca ccagccatca
    20041 gagcaagggt accagcacag atagaagcct gagaagacga accgttagat tctagaactt
    20101 cggcaactaa acgaatggca taaggaaatt cttctaagct tggcaagact tgttcaagag
    20161 cgcgttcacc taaggcaccg tgtccaattt cacgacgacc agcagctccg taacgacccg
    20221 tttcaccaac tgaatattgc gggaaattgt agtggtgtaa aaagcgtttt ttgtactctg
    20281 gagccagacc atcaatgatt tgagtttctc ccattggtgc caaggtcaaa actgatagcg
    20341 cctgagtttg accacgtgta aagagacctg atccatgtac ttttggcaag aagtcaacca
    20401 cagcatcaag cggacgaatt tcgtcaatct tacgaccatc aggacgaatc ttgtcctctg
    20461 taatgaggcg gcgcacttca gcatgctcca tttgttcaag gatttctgcc acgtcacgca
    20521 taatggttgc taggttttcg tcttctgcgt aacgctcttc gtactcagcc ttaaccattt
    20581 ctttaacggc ttctgtggct gcttcacgcg cttttttctc ttcaacttga acagcttttt
    20641 gcagttgagc attgtactta gccacaatat cagcttgtaa gtctgcatca acctgtaaca
    20701 gttcaacctc agctttttct ttaccaacaa ctgctacgat ttgttcttgg aaggcaatta
    20761 attcttgaat agcttggtga ccttttaaaa gagcctcaag catgatgtct tctgataatt
    20821 ctttggcacc agattcaacc atgttgatgg cttctttgct accagcaacg gttaattcta
    20881 agagcgacgc ttccatttgt tctttatctg ggttgatgat gaactcgcca tcaatatagc
    20941 caacttgaac acctgcaatc ggtccattaa atggaatatc tgagatggac aaggccagag
    21001 atgagccaaa catcgctgcc actggagcgc tagcattttc atcataagaa aggacagtgt
    21061 taatcacttg tacttcgtta cggaaacctt cggcaaacat gggacgaatc gggcggtcaa
    21121 tcaagcgagc tgtcaaggtc gcatctgttg aagggcgtcc ctcacgtttc atgaaacctc
    21181 ctgggaattt accagcggca tacatttttt cttcgtaatt aacttgaaga gggaagaaat
    21241 cacccgttgc cattttctta gacatgacag ctgcggtcag gacagttgag tcgccataac
    21301 gaacaacggt tgccccattg gcttgcttag cgacttgacc aacttcaaca acaaggggtt
    21361 tccctgcaaa tgttgttgta aaggtttgtt ttgacatata ttctcctttt aattttcaga
    21421 ggggtaaaga ggtacctgtt ctctgcttag attcaattgt tatacgttgt tttgctacaa
    21481 aaagcaacct gccacgcttg tcacacgctc ctctttgtat caaacgacgt atctgctaca
    21541 ttttaccata aaatagcaga aatttcactg tcagatcgca atctcttgaa atgtccttga
    21601 aaaatattaa acgaaactta tactctttaa caaagcaaaa aaagcaggtt ggtatacctg
    21661 ctttcgtctc ctaatattaa tgtttggcat cctctaaaat tttaaagccg aggctggtac
    21721 tgtctttcag aaacatttgc acggcttcaa gggaatagtc ttctaaatct tttccttgaa
    21781 gaggcaactt ggcaatcaaa tcagtggtac aagtgataat gtccacgcct agctgatcag
    21841 cttgatagat attataagtt tcacgaggac tagcccacaa caattcgacc tcttcttttt
    21901 gacgacaaat gcgtagagct tcttccatga ttggcattgg gtcaacgccg gtatctgcaa
    21961 tacgaccagc aaaaacagac acaatagctg gaactccagc ggttaaatga tcaaccacag
    22021 cttgagtctg ctcaattgta aaaatggctg tgacgtttaa cttaatgcct ttggctgaca
    22081 acttttgaat gaggggacag gttgattctc ctgttgaagt ggtgactgga attttcacat
    22141 agacattgtc acctagactg gcaattttct cagcttcctt ttccatgctt gcgagatcat
    22201 ccgcaaagac ttcaaaggac actgggtagt ctgtaatttt ggcaagcact tctttggcaa
    22261 agccaatata agaactgatg cctgcttttt tcatcaaact tggattggtt gtaaagcctg
    22321 tgaccaaacc tgtttgtaaa tcctttaaca tggtctctaa gaccgcaccg tctgaaaaga
    22381 ctttaacgtt tagttttttt gtcatcatat cctcctttta gatttcttct gaaacattat
    22441 tgatggcttc ttgagatttt gacagaaagt ttggaagcac caatacaata gcaagcacag
    22501 caaccaccaa gtaaataccg atttgaccaa tcgacgttcc taagcggccc agtaaaatcc
    22561 ctaaaacacc gaaatccaca tctccaaagg tcgtgtttga aaaaccaagt ttaccaagta
    22621 caggtagaag catggctggc aagaaggcga gtaataagcc attagcgaaa gcaccaatca
    22681 ttgcaccgcg acgaccacct gttgaatttc caaaaatccc tgctgttgca ccgcagaaga
    22741 aatgaggcac catacctggg ataatcagga caccacctgc aactcctaaa atcaacatcc
    22801 caagtaagcc accaacgaaa cttgacgcaa aaccgatgat aacagcggtt ggcgcataag
    22861 ggaagaatac cgcacagtct acagctggaa tagcatttgg aattaatttg ttagcaatac
    22921 cttggaaggc tggaatcaag tcagccaaaa tcatgcgaac accggcgtag acaattgcca
    22981 caccaaccgc aaaggtaaga ccactcttaa tagcaaagat aaatgggttt tgacctgctg
    23041 ctaattcttc tgttactgaa gcattcctca aaacagaagc cactgttgcc accaagtaga
    23101 aaatcaccat gataagtcct gttgaaatgg tggtgttgcg taagaaactc catttttcag
    23161 aaatctgaag gtcctcggta tctttactgt ctttgccaac cttgctacca aaccaggcag
    23221 aaaggtaata gcccaaacta ccaaagtgtc ccatggcgat ttcatctccg tcagtcactt
    23281 tcaacgtata ctgtcgacca atggctggcg aaatagctga ccaagctccc aagaggaacc
    23341 cacctaagat aatcaaaaga cttcctttga aaccaacagc tccaagcacg gcggacaaga
    23401 gacaagccat aaagaagctg tgatgtcctg ttaagaaaat gtatttgaag cgggtaaaac
    23461 gagcaaaagc caaattgagc aataacccaa ccaccaagat ggacatggtt tccacaccca
    23521 gaatcttttg agcgacagaa gtgacggctt cattatttgg cactacgcca gtgatgctaa
    23581 aaccgtgctc aatgagtttg gcaagagggt ccagattggc cacaataaca cccgcccctg
    23641 cagcaagcat aaggtatccc aaaatcggcc ccaaggttcc tgtcaacacc ttatgagcag
    23701 gtgttttcaa agccaccaac cctgcaaagg caatcaagcc cattaaaaat gcaggttctt
    23761 ttaaaatatc tcgaataaat gataataatg cttccatagt atcttcctat ctcctttaaa
    23821 ggcttattcc ttgccactca tttccttgag aaccggaacc aaatcttctt caattttttt
    23881 acgattggta tagcttttaa cgatacaaac cttggcatcc tctggaaaaa tatctttaaa
    23941 ttctttaacg gtaacaaaca aatctgcacc ctttccaaca gccgcattgg aatcacagga
    24001 ttctgcatcc acatcaatac ccaaactaga tgcgatagct tctactttca tgcgaagtaa
    24061 caagctacta ccaataccgt ttccacaaac cgttacaatt ttaatcatgt gattcatctc
    24121 ctttttcaat catatggcta atcagactca ttatttcctc agtattctta gcctcaatta
    24181 attgctcaat atgttcatca tcatctaaaa tcaacgacag ttcctgcaaa gccttcaaat
    24241 gtgaactaga atccacagca gacaaaacaa aaatcaattg cacttgcttg tctggatcac
    24301 cttcttgctt caaatcaaag ctgacaggtt cttttagttg taagagagac atgcctaact
    24361 gccgcgttcc tttttcaggc gccgcatgag gaacagccac cttaggggtt aaaacaatat
    24421 aggccccaag ctcattgact gaatcaatca tgccatcgat ataagatgtt tcaatcatct
    24481 ggtgttctag taaaggctga gcagccaaac gaatcgcttc ctgccaatcc gaaacagcat
    24541 cagcctgcct aataaaatct gctgttaaca agtccaatag tcctagacct cctttttcaa
    24601 tcgttaaatg gttaccaatc aggtaacggg ataaatcact aacaagtcct tctttattag
    24661 taatcgtggt gtgtttatga ataatactca acaggtcatc caaagcgaat tgctctgaca
    24721 agggaagatg aaagtcatca cagaccatct ttttcaacat cattttctca acaggcccca
    24781 tcaaagcttg cgtcacataa acaggtttag cacagtcaaa agctactgtt gaaaaaatca
    24841 aatcaaagga agctggatcc aacaacttta ttttgtccag ctggtgaatc ctaataaact
    24901 gtagctgtgg aaaaagttcc ttcaaggttg cctccaacat cagagacgaa ctaatgccat
    24961 tagggcaaac agataaggct accagctgat tgctcggcct cttcttaggg gcctgcaacc
    25021 atctcccaaa atgaatggta aaataagcaa cctcatcttc attaactagt ttccccaatt
    25081 gtttttctag aggagaaagg ctgcgcttga ccaagtaaaa gagagattca taatcttgtt
    25141 tgatttgttc cttcaaagga ttggtcaagt taatgtcgta gtaaagtcgg taataagctg
    25201 gcaaaaggtg actgtatagg ttctgacgaa gttctggggt atcggtgata gacaatcccg
    25261 tgttaaccgc caccgaattg atgatttctt ccataatgtc ataaataggt tgctgaaaga
    25321 ctaactctaa gtcaccttgg atacaaccaa gtaacctaga ttgaaccaaa tatttttctt
    25381 cggttagact ggggaagttg accaataact ggtccaccat cgtttcaaca gctggcgaag
    25441 ctaaaggaaa agtatccact gcttcagccc ttacattccg tgaaaatggt cgatgagcga
    25501 gaaggcagaa aaaataaatc aaatccctca atttctccga aataaaagtt aagtggttct
    25561 ccctgctcag ttcctccaac gttgctgcca tcacctttgt ctggtcgggc aaaccaagtt
    25621 catgcaataa gtaactgaac acccaaggtc ctgatgtaac ttgcaaaaga gaactgaccg
    25681 ctgattctaa gagacgccgc aaggctaagg gttctccttc aaaaaaataa ccatcctggc
    25741 gattgtaagc taaagttacc tgaaaagctt gtacccgatc acgcaccaag tttaaatcag
    25801 caataacgga atttctgctg agccgtaaca agctttccaa gtggttaatg gagataaatt
    25861 ctttagccat catgatgtaa atgataatca tgtccagacg ctcatcttga aagagatagt
    25921 cgtctaaggt aggtagcatg cgattcaaca agtccttttc agtaaggtct ggcggataaa
    25981 ccagctgcct gtccagagca ataaggggta actgatagag tgacaacgtg tcattgattt
    26041 tagcaatatc tgccagtata tgacgtttgc ttgtctttaa catggattca aatgcctcca
    26101 gtgaatgtcc tttatattta gaaaagagtt gatagtttct gatgagctca tgagatagca
    26161 tgtcatctcc tcctataatg tcagtataaa atgaagcgtt ttcattttca agacaaattg
    26221 agtccaattg tctctcgtca tttttgaccg caattggact caacaggtga tatcattgta
    26281 acaagttcct caaaaggtgg caaaaaatag acaaatctgg gaattgattc cctttttctt
    26341 catgatacaa caaaagatac ctcatcactg agataccttt tgttattaga taaaatcatc
    26401 aattgctaaa aaaacaacct tagaccattc tagccaaatg tgtaagttaa caaacaacat
    26461 gtcaaaaatg aaaaagccca ctgcataagc agaggacttt ttaaacttga aattaacgac
    26521 gaagtccaag agattggatc aactcacggt aacggttaac gtctgtacga cgtaggtatg
    26581 ccaacaagtt acgacggtga ccgattttct tcatcaatcc acggtaagta gcgtggtctt
    26641 ttttgtgttc tttgatgtgg ttgttcaagt ggttgatttc ccatgtaaga actgcaactt
    26701 gaacttctac tgaaccagta tcaccttcgt gacgtgcata ttgagcaatg atttcatttt
    26761 ttttctcttt tgagattgcc ataatatatt ctcctttttt ttgcttaatc cgagtcttag
    26821 gattggcact cctaaaacca agaaaaagtt ggtttgtctt tcgaccactc tattctagca
    26881 gattcataat attaggtcaa ccgttatcct attattctaa gctctcacat ccaaaccacc
    26941 ttaagcaaca gaactagcaa ggccaaatag ccaagaggct gtttttaaat cagaataaac
    27001 ctgtgcgatt gcttgcctaa taagataacc agctaaaaga ggtaagatgg ctgatccccg
    27061 cacttcagct gataagcggt aacctagcat agtcattcat ttctttccaa caaagtgttc
    27121 actgataata ttaattgctc tagtattaac aaacccaatc cctaatccat gaacacagct
    27181 tattaaccga tgcaacctgc ctttatgaca taggtcaaga gttgacacaa aatgtttgcc
    27241 aacaaaacat tacctatacc gtcaaagagc gctttgcttc ctatatcctt gaagcgcaag
    27301 ccaaccaaga ggttcatctg aactttacat tattagcaaa ccgttttgga ataagtgatc
    27361 gccatcttaa gcacgtactt aagcagctca tttttcagag gattatcgaa cgcatctgct
    27421 tcaaaacctg tcgtattgcc gatttagacg ctctaactca attaagtgtt aataactaga
    27481 cctctgaggt atgcagccca ttaacttata atagcaatca ctctgaccac tacctgactt
    27541 ttctttaaaa aagaaatgat ttgtgatata gtaaatccag ttaaaaaaaa agtaaaggag
    27601 tagacatgtc tgcacaagat aaattaatta aacctagtca tctgattacc atggatgaca
    27661 ttattcgtga agggaatcca actttaagag ctgtcgccaa agaagtgagc ttacccttgt
    27721 gtgatgagga tatcctatta ggagaaaaga tgatgcaatt tttgaagcat tctcaagatc
    27781 ctgtaatggc ggaaaaactt ggtcttaggg ccggtgttgg tctagcagct cctcagattg
    27841 atgtgtcaaa acgtatcatc gctgtgctcg ttcctaatct tcctgataaa gaaggaaatc
    27901 ctcctaaaga agcctatagc tggcaagaag tcctgtataa tcctaaaatc gtttctcatt
    27961 ctgttcaaga tgcagccctt tctgatggtg aaggttgttt atctgtcgat cgtgttgttg
    28021 aagggtatgt ggttcgccat gctcgtgtta cagtagacta ctatgataaa gaaggacaac
    28081 agcatcgcat caaattaaag ggatacaacg ctattgtggt tcaacatgaa attgaccata
    28141 tcaatggtgt tttgttctac gatcggatca atgctaaaaa cccctttgaa accaaagaag
    28201 agctcttgat tttagactaa caaaaaaagg ccctttagcc tttttttgtt agtctaaata
    28261 gccgctaaaa gagcctctgc ctgagatagc aagtttgctt ttgtctcttt tgaaatctca
    28321 agccttcctg ttccccaggc atcaggattc acagttgctt ttgtaaactc tcctgctact
    28381 gaagttcgga taaacggcaa tagtgcttta aactgatcaa atacttgatc atgcccgcca
    28441 tttgcaactg aagagaccgt aaccacctta ccgccaatag cagatgggcc cgtcggatca
    28501 gacaaatcaa gagcacgaga caaccagtct agcaggtttt taacagaacc tggaatagag
    28561 aagttgtaaa ctggtgtaaa aatccagata gcatccgctg actgaacagc ttgacgagcg
    28621 tcaacaactg gtaaaggtgc attagcttcg atatcttgat tcaaaacagg aacgtctttc
    28681 caatttaagt aagctacaac tgcttgatgt tccagagctt tttgtgcttg agccgctaat
    28741 tgatggttaa aagacccttc acgaagcgag ccaacaataa ataaaatatg tttcatctct
    28801 ttgtcctctt ttttaaagat cgttttaaag ctttctaaaa gtggtatttc attgatactt
    28861 ctttttgaaa tttatcacta tgtagtaatt atatcttctc taagaagagc tgtaaagaga
    28921 tttgtttata attgtttgaa ctttttgaga agttcaatca gacaaagttg ttctttttca
    28981 gtcaaaacag caaaggcttc ttccacccgt gcgacgtgtt taggcaaaac agcttcaatc
    29041 aagcgagtac ccttatctgt taaggtaacc acataggctc ttttatcagt tttgtctttg
    29101 cacttgctaa tccagccatt acgttccata ttatttagta caacagtcat attccccgaa
    29161 gtcgctaaca aagaatcaat caagtgattg attcgcatac agcctttagt atatagtact
    29221 tcaagcacac tgaactgcgt ggctgttaaa tctgcctttt taaaaatatc agccccaaaa
    29281 gcatctagcg ttcgctgagc tttacgaaac accaccatgg ctttcaaagc ggtgttctta
    29341 tctaaatgac tcatttgatt tcctcgcttt atacggtatg tcacagttta gtatcagaga
    29401 gattagaaag tgatcttgtc cctcttcttt tatgactttg catatgacta ccatcatgat
    29461 aatctagaaa aagtcatcaa aaagacttaa ttgattatct tctggcatat ttcctaaaat
    29521 acccatctca tccattttct caacgagcgt tgacgatgcc ccgcctcgtt tacgcaattc
    29581 cattttagag aggaattcgc cttcttgacg agctttaacg atttgcttgg ccacgttttc
    29641 acccagacct tctaacgcta taaatggagg gataagggta tctcctttga tttggaattc
    29701 tatagcatca cttttgtaaa ggtctaattt gccaaactta aagccgcgtt ctaacatttc
    29761 gttgacaatc tccaaggttg taaagaggtc attttccaca ttggtggctt cattattttt
    29821 acgttttata gtaatatctt ccattcttgc tttaacagca tctaagccac cactcatggt
    29881 ttttaattca aaagccttcg cacgaataga gaaataagca caataataca taatggggtg
    29941 gtgcacctta aaataagcta cccgaagggc catcaagaca taggccgccg catgggcttt
    30001 agggaacatg tacttgattt ttccacacga ttcaatgtac cagtcgggca cattgttttc
    30061 tcgcatggca tcaatatagc cattacgttc ttcctcagaa atttttagcc agaggccctt
    30121 acgcacacgc tccataatgg taaaggccat tttcggttct aagccagcgt gcatgaggta
    30181 aaccatgatg tcgtcacgac aaccgataac ggtttttagg gtcgcaatgc cttctttaat
    30241 caaatcttgt gcattaccaa gccaaacatc ggttccatga gatagtccag acaactgcaa
    30301 aagctccgca aaagtggtcg gatgcgtctc attaaccatg ccgcgaacaa agttggttcc
    30361 aaattctgga atgcctagca taccagtcgg tgtcccaatt tgttccgggg taacgcccaa
    30421 aacctctgtc ccagaaaaga gagccataac tcccggatca tcagcaggaa tagtaatagg
    30481 atcaatgccc gataaatcct gaagtttacg aatcatggtc ggatcatcat gccctaggat
    30541 atcaagtttc aagacgtttt catcaatatc atggaagtta aagtgagttg tctgccaaga
    30601 agccgttaca tcatcggctg gatattgcac gggggtaaaa tcataaacat ccatgtaatt
    30661 aggaataaca acaatccccc cagggtgctg cccagtcgtt cgtttcacac cagcagcacc
    30721 tgctgctaga cgatccacct cagcatcacg atagaacttg ccatagtcgc gttcatagcc
    30781 tttgacaaat ccataggctg ttttttctgc tacggtacct acggttccag cacgaaaagc
    30841 atactcagca ccaaaaatat ctcggacatc caaatgggca ctgggttggt catcaccaga
    30901 gaagttcaaa tcaatatcgg gcaccttatc cccgtcaaat ccaaggaagg tctcaaaggg
    30961 aatatcttgg ccgtcttttt gataaggggt gccacatttt ggacaaggtt tattaggcaa
    31021 atcatagccc gatccaactg acccatctgt gataaattca gaatgttggc aagacgggca
    31081 aacgtagtga ggcggcatag gattaacctc ggtaatccca atcatggtgg ccacaaaact
    31141 agaccctaca gatcccctag aaccaactag gtagcctcgc tcatttgacc ggttaacaag
    31201 catttgtgac gctaggtaaa tcacggcaaa accgttcccc aagatagagg ttaactcttt
    31261 ttcaatgcgt aaatcaataa tatctgggag aggattacca taaatttcaa aggctttttg
    31321 ataggttaat tcggcaaccg tctcttcggc cttgtcaata tacggggtgt aaagatcgcc
    31381 cttaaccact tccacttcct caatacggtc cgcaaaatcc tgagtgtttt ctacaaccac
    31441 ttgataagcg aggtcttttc caagaaaggc aaactcatcc agcatttcat tggttgttct
    31501 aaagtgcgct ttaggtaggg gagcaggttg ggccccttcc ccacggccga ttgttctatt
    31561 aatcatggca ccctgaccga gactacgcac aataatttca cggtaaatct cttcttcagg
    31621 ctctaggtaa tgcacatttc cagtggcaag tacaagttta ttagctcgtt tccctacttc
    31681 aatgaggtca cgaatcacct gctcaatacc tgcttggtct ttgattaatt cacggacaac
    31741 caatggctgg taaatggctg gtggcatgat ttcgataaaa tcataatact tagccaaatc
    31801 aaccgccgca tcaattcctt tagtcagaac ggcatcgaaa acttcaccat ccgaacaagc
    31861 tgttcctagt aacaaaccct ctctgtgagc atctaagacg gttcttggaa tacgcggcac
    31921 cccttcaaaa tatttgatat tggaaaggct gaccaactta aacatatttt taagaccaac
    31981 ctgattttgc acatagatag tcgcatgctt aatccgcgct tttttgtaag agtcctcagc
    32041 taccaaatct gtattgagtt gcaaaaggtt tttgatgcca tgcttttctc tggcatcttt
    32101 tagaaaaata aacaaaagac gtcctgtggc ttccgcgtcg taattggcca tatgatggtg
    32161 gtctagactc acttggaaac gcttggtgag tggtcccaaa ccgtgacgtt tgtattcagg
    32221 atataaattt cttgcgaatt ctaaggtatc aatcacaggc tgtgtgattt tgggcaagtc
    32281 atggcgttca taattggcgt tcataaagcc cacgtcaaaa ctggcgttgt gagcaactaa
    32341 aatactatct ttgcaaaagt cctgaaaagc ttttaggacg gtaaccaatg gcttggcgcc
    32401 ctgcaaatgc ttatcggtaa tccctgtcaa ttcggtggta aaggcagaaa gaggatgccc
    32461 aggatcaatg aattcatcaa actgctctac aatatttcct ttaaacattt tggaagccgc
    32521 aatctgaatc aggtcattat tcatagcaga tagacctgtg gtttccacgt caaagaccac
    32581 ataggtagct tcgtgcaaat ccatatcaac aggatcataa gaaataggca ccttgtcctc
    32641 aacaatattg gcttctagac caaaaatagc cttaattcca gctttgcgag ccctatggta
    32701 gccatgagga aaactttgca cattagcatg atcggtaata gcaaccgcct tgtgtcccca
    32761 cttggctgcc gtatcaatca agctttctac tgtcggtaag gcatccatgg tagacatatt
    32821 ggtgtgggca tgaagttcga cccgtttttg tccttctggc atcaggtctt tgcgctcatg
    32881 atggacaatt tctttgacct gctgaacatt catggtgaga ctcttcgtaa aaggattggt
    32941 ctcaatatta ccttgtaccc gtaaccaagc ccccttagca atcatatcaa atttacggag
    33001 ctcctcatcg tctttagccc atttttggag agcaaacgag gaggtatagt ctgtcatttt
    33061 aaagttgatg atatggcgac ctgttctagt cgttttacgc tccacatcaa aaaccatccc
    33121 ctcaaagaca atccggtttt cttcggtctc aatctcaatc attggtgtga tggtcgcttt
    33181 ttcaaaccct gcctgacgct tagctgctcg ttccttgtag tcaaacttag gagcaggtgt
    33241 ggcttcctca actggtggca tcatggcttc aagggatttt tgggcttcca aattatcctg
    33301 cacagccttt ttcacaagag cctgacgact ggaaacaaaa tccttggtca aatgctcagt
    33361 catctcctga tctgacacca tatctatggt caaggtgcca aagccaaagg cttcaaattg
    33421 cttgaccaga ttaggcagat gattgtttct aaaatgatcg ttattcacaa aacctggcgc
    33481 tgcaataatg agtttgtcat cctcataagt cactttgagc tttgagaaag aagatttaaa
    33541 actagcacta ttacacggtg catgctcaaa agcttcttgg taataagctt gaagcagatc
    33601 atctgaataa tccacctgag cagcttggat atcaaaggtt accttaatgt cagccgcctc
    33661 aaaagttctt atcaaacgat catgtaattc acgataagtt gcaatcggta aaaccgccgc
    33721 aaaggcaaaa tgaaattccc acaagcgtga caccgaatgc acctttacct cgataatatc
    33781 agcagatgaa aaggcacttg aacgtctcat gtcaagtggc atttctatct ggtccatcaa
    33841 tttagcgaat aaatctgaca taattttctc ctgattttac taggctttat tttatcacaa
    33901 ttcaagatga ttttcgagtt ttagatggaa agaaaagcag ggctttcttc tgacgttctt
    33961 tggctaattt attccaagtg atagctcagc tgaggtcatt tttttaccaa tcttttgtcg
    34021 ccaagcgctt ttggtaaagc aaaagccact ctgtatcaga caagttcaca gcaaaaagag
    34081 gctactctaa acaggcagcc tcttcatttc ttttttagtg ttcttttgtt aaaatttcaa
    34141 gggtttcgat gaggttttct gcattaactt caatgctgtc acctgttgcc ttgattttaa
    34201 tttccacgat accttcagcg gcttttttac caacagtgac acgaattggc aaaccaatca
    34261 aatcgctatc agagaatttc gaaccgacgc gttcattacg gtcatctgtc aagacatcat
    34321 accctttagc catcaagtca gcttctaact tcgccgtcaa gtcttgggcc acttgatctt
    34381 tgacattaac tgtaatcaaa tgcacgtcaa atggggctaa ttctttaggg aagttaatac
    34441 cccaagcata acggtaatcg ccttttggtg tcttgttcac aaagagacgg gcatgctgtt
    34501 caatgacagc agacaaaatg cggctaaccc cgataccata acaacccatc acaattggaa
    34561 ctgttctgcc attttcatca agaatcgttg ctcccatgct gtctgaataa cgagtgccca
    34621 acttgaagat atgaccgact tcgataccac gcgcaaactg gagaacacca tgaccatccg
    34681 gagacatttc cccttctttg acttcacgaa tatctacata ttcagcctgg aagtcacgtc
    34741 ctggattgac tcctgtcaca tggaaaccat ccttgttagc tcctgcaacg gcattggtaa
    34801 ggttttgcac tttgcggtca gccacaatgc gactaccttg tgccaagttg acaggcccaa
    34861 gtgagccaaa acctgcacca aagaaagcac gggcttcttc ttcactagct ggctctaaaa
    34921 aatcagcagc tagatagttt tttaatttaa cggtattgat atggtcattt ccaactagca
    34981 aagcaacaac aggttcatta tctgccacaa aaagcaaggt tttgatggtt tgtgtttcat
    35041 ctactgaaag aaaagcagcc acttcatcaa tcgttttgca atgtggtgtc tcaacttctg
    35101 ccaaggcatc ttcagcagct acttttgagg acggtttgta ttcgttagtt gccatctcaa
    35161 ggttggcagc gtagcttgat tctgttgaat aagcaatagt atcttcacct gaaatcatcc
    35221 aagcagccaa ttctgcctta atctcttcta agacctcttt tggaatatca tccattgacg
    35281 caatagactt gtcaagaacc acccagcgat caaggtccgt acgagctggt gtaatggcca
    35341 taaattcttg ggaatctttc ccccccatgg caccgccatc tccaataatc cctttgaaat
    35401 ctagaccagc tctggtaaaa atagcttcgt aagcttgacg ataatcttcg taggtcacat
    35461 ctaaatcttc atagttgtga tggaaactat agccgtcttt catgataaac tcacgggtac
    35521 gaagcaagcc gttacgcgga cgtttttcat cacgatactt agactgaatt tgataaaggt
    35581 ttaagggcaa ttgcttgtaa gatttgaccg catcacgcac caaagtcgta aaggtttctt
    35641 cgtgggtcgg acccaagata aagtctgagt tatcacggtt tttaagctta tagaggtcct
    35701 ctccataggt ctcataacgg cctgattcac gccagagatc agctgtcaaa agagctggtg
    35761 ccaacatttc aacagcaccg atcttttcaa actcttcacg catgatggtc ttgaatttct
    35821 caatggtacg atttgccagt ggtaaataag catagatacc agcagaaact tggcgcacat
    35881 aaccggcacg caccataagc gcgtggctga taacctgggc atcacttggc atttcgcgca
    35941 aggttgggat aagcagttta ctttgtttca tagattattc cgttttaata catcccctta
    36001 tcctcaaacc cttctggaaa catcaagtaa gagtgaagcg ggattattca ataatttgaa
    36061 tgtgtattcc tttcattttg agtaagactt caacccttgc aaaccttagg gttgaggtct
    36121 ttttcgatct ttaacatgat aaggtcagct taagatgacc tatcttgatt agaaaaagac
    36181 gcgcatgata tcattccatg tcacagcaat catcaatacg accatgatag caaccccagc
    36241 tagggtgata taggcctctg tttcttgctt gataggcttg cgacgaatgg cttcaatgat
    36301 attcatcaag atttttcccc catcaagtgc aggaatcgga atcaggttaa agatccctaa
    36361 attgatcgaa agcattgcca taagagataa gactgactct aagccgtttt gagcagcctg
    36421 attggacatg tcatacatgg caacaggtcc acctaattta ttgagactaa agccagtgat
    36481 caatcctttc aaagtattca aaatagtaaa cgccccactc caagctaatt ctagaccgcc
    36541 taagagctta tccttaaatc ctgttttcag actcgcctta actcctatcg tgtatgtctt
    36601 tgcatgcttt tgtggtttca cagccaccgt ttttaagcgc tgatgtgact tgtaggtgac
    36661 cttaatggtc tgtgacgggc ctagatcccg tgttgcaagg tctacagcct cagtgagatc
    36721 attccagcta gtcaccttgt aaccattaat tgcgacaatt tggtcattat ctcgaagacc
    36781 agccttagct gctgctccat tttcttgaac acggacatga ttgctactaa aatctggcat
    36841 cccaccttgt aaaaagacca agaggataaa aaccacaatc cctaaaataa aattattcat
    36901 gggacctgca aaattggtga ttaaacgtcc gccaatacta gcattttgat attgaacatc
    36961 aagcggagca attcttatct cagtaccgtc ttcttcaaca atagtagcat cgtgagcgac
    37021 cttatatgtc ttggtttctt ctaaaaccaa gccagtaata ctcagctgat cttctaagtc
    37081 atagcctgta acatgcattg ggagactcgt tgggtctaac ttactttgag acaagttgat
    37141 gcgcttaaca aaaccttgct cattaagggt taaacttgct ggagtacctg ttttgatctc
    37201 agttttgtca tcaccccaac cagccattcg cacataaccg cccaagggta acatcctcaa
    37261 ggtataaaga gttcctcctt ggtcaacatg agaaaaaatt ttagggccca ttccaatggc
    37321 aaattctctt actagaatgc ctgatttttt agcaaaatag aaatgtccaa attcatggac
    37381 aatcactaaa ataccaaaaa taataataaa ggttattatt cctaacatag atttcctttc
    37441 agtctattgc ttttttgagt tctgtcgcgt tgttgcgact ccaaacatta cctcttaaga
    37501 ttaaaataaa ccaaagagat gcatgatggg aaaaacaaaa atcatggaat caaagcggtc
    37561 taaaatacca ccatgtcccg ggataagctt acctgaatct ttgacaccaa agtgacgttt
    37621 gagagcactt tcaaccaaat caccaaattg ggcaaaaatg gaaaaaagag cgaccaaaac
    37681 caacatggtc aaaaagtgat gtggtgcata aacagaccta tcgatcatca taaagataaa
    37741 agacacaagg actgcacaag cgatccctcc taaactacct tcaatggttt tgtttggaga
    37801 aactgtaggc aatagtttgc gcctgccaaa ctgacgccca atcagatatg ctccaatatc
    37861 agtggcccaa acgataaata aggccaaaaa gaccttgtca attcctgaca ggcgagcatt
    37921 gatcaaatgt tgaaaaccaa tcccaacata aaaactagtt gcaatcggaa aggccgcatc
    37981 atcaaatgaa taagctctgc tatttaaaac agtacctgcc aaaatgaaaa aaaccattaa
    38041 gctataaaaa gcaacattcg catcaattgg taaaaaagtg aggtaatggt ccatcggaac
    38101 tgccaataca aaggcggcta acatggcaaa aacaccttca aaagaaaaga cttctaatct
    38161 tttcattttc agtaattctg ataccccaat catggccaaa acgcctacaa ataattggaa
    38221 tggtaggttt cctattatga gaaaaggtag gaaaatagct actgctactc ccccccaaac
    38281 aacacgttct ttcataacta tctcctttta gaccttgcca aaacgacgtt ggcggcggtt
    38341 ataatccgca atggccttca gtagctctgc ctttttaaaa tcaggccaca agactggtgt
    38401 gaaataaaat tcactgtaag ctgattgcca aggcaagaaa ttgctcaaac gcagctcacc
    38461 actggtgcga ataatcaaat cggggtctcg gtagagatat ggcagatggt ctgtcatcaa
    38521 ataattagca atcaaatcct ccgtaatatc tcctggattt aatttggcat ctaagacatc
    38581 ttgagcaata aagcgaacag cactggtaat ctcagcacgt cctccataat tgagagcaaa
    38641 attcaaaatt aaacccgtat tacgttttgt tttgtcgatg gctgcattta gcgctgccaa
    38701 ggtatcttca ggtaaacgac tagtctctcc aatcatttga atctttacat tgttctcatg
    38761 aagcacaggc acatatttgt caaagaaggt tactggtaaa ttcatgataa aagacacctc
    38821 atcttggggt ctggaccagt tttctgtcga aaaggcatag actgtcagaa ctttaacccc
    38881 caactcagat gcagtaatcg ttacttcttg taaagcatcc atcccagctt tatgcccaaa
    38941 cactctaggt tttagtcttt ttttggccca acgtccatta ccatccatga taattccaat
    39001 atgctttggg atactcccca aaactttttt tgttgatttc gcttttaatc caaacatgtt
    39061 ttttccttat tgataagcat acttatctca tattttaaca tatttcacgc cttttggctt
    39121 gttttttatc aattagatct tatcttcaca aaatgttcac ctatcctttg atagatgtgt
    39181 cagcttttca tgaacctgtt agcatcagaa taactgtttc agtccaggga tcaaaacaaa
    39241 aaagtttggc atatttcatc caaactttcc ccgccttaat ggctttcaat ggcactgtca
    39301 gtgctatcta ctgtctcaac agcaggctca ttaacaacac tggtttcttc tgtttcaacc
    39361 agtgtcgttt ctgtggtagc ttttgttaca atacgcttaa tagctgatag ctcaaatgtc
    39421 aaaaagacgc catccacatc taacacaatc tttttagctg ttgtatcgac ttcgtcaaca
    39481 atcgcaaaca tgccaccaat cgttacgact tcgtctcctt tttcaatagc gtttaactga
    39541 ttttggcgtt cttgcgcttg ttttttttgt tgacgttgca taaaccaaat caatccaagc
    39601 atcactacaa acattaaaat tgttggaaat cccataatgt ctccttttta ttctataaaa
    39661 gtcatgtctt actatatcaa aaatcaagcg gtatagcaag actagacgtt acctgatttc
    39721 ttctttaaac gagacgctaa gcgcagtgct ttactcacga gtcaaaaaag ctaagatgtc
    39781 atctggtgtc aaacttgaat cacatacagc cctttggtgc tgatcgtaac taaccagcaa
    39841 agctggaact gtcactaatt ggtagttctc acgaaaggca gcaagctcag cagcgtcagc
    39901 agcgttttcg ctatccacaa aatagacgtc tttttgatta tctgttgcca cttgtgccaa
    39961 cttaggagca aagcggcgac aataaggaca gctcgaacgt cctaaaaaga caatcatgtc
    40021 tttgccacta gcaatagctg atgtgacttc tgcaacactc gacggtataa aattcgcaac
    40081 gatttcttca aatgtcatgg atgtctcctt ctcttttggt cttatgatac actaaagtag
    40141 caattttctc aatcacaagg tcttttcaca gctcagagct tttatagccg tcaaaaagaa
    40201 tccgcaaaca gcaatctttt tgtctctatt aacaccaccc taatcttttg ggcgcttcat
    40261 caacaggcta atagccaata aaagcagagc tactccagct gctaataagc cttttgagga
    40321 ggcttcaccc gtttttggga gcttttggtt tgtttgagct ctttttggcc tagtcattaa
    40381 tgatttgtct aggtcttttg agccatctgg tgttttggtt tgatgattgc ctgtctgact
    40441 ctttttctga gagggatcag ccggttttga agatactttg aggaccaggg cagttaggct
    40501 atcaatagtc aagccttctt tggtaaactg gactccctta ggcttagcaa tggcagtaac
    40561 accagcttgc tcagcatcag caagcacttg ggctcctagc aaatagcggt aggcttgagg
    40621 taaaactacc ttgcgggtct tgttgtctgc attgacaaag acagcatagc gatctccatt
    40681 tgatgccacc gtttggtaac ccatgataag gtcctcttgt tgaataacat cttgtcctgc
    40741 ttgggtgatc aaggtcacat cccgatctac ctcagctttg gttgcttttg taaaggcatc
    40801 tgttgagcga cgcaacgcaa ttagtccctg tgtataggct tttgtttggt tgctaatcgg
    40861 gtgagctatg gaatctgttg cctttgccca gtcaaaatga ttgaccgcat cagacgaatc
    40921 ataagaatcg tggatgaagt aagggtattt cgctacagca tcaatcagag tcgccttatt
    40981 tggcaccttg tcatcagaca cctttgtcct gtagtcggga tttagaagct gcttggttcg
    41041 tccatattcc tgaccagaat ggataaaggc agtcccttga gcagttaaaa tcatggtatt
    41101 tcctagacga atacgcttat gaatctcttc ttcagccact ttaggatcct tattgatgga
    41161 tttggcaatg acatcatgta aggtcaggtt gtcatgggct gcaatatact gcactacatc
    41221 tcctggggca tctgcttcaa agttactagg ctgtgctttg atcgttttga acagtccttc
    41281 tagatttttt gcgccaccag taataaaggc tgctgtgcct tcatttggga aacctgactt
    41341 gagggtattt ctgatatcat cagagaaaac accgaccgta ttggttgctt tcatccaatc
    41401 ttgatctgcc gcaatttctt ttttcccctc atcaccttgg taggtacgcc agccttcgcc
    41461 aatcataatg gtatttggat taatggcttt ggctgcctta aaggcttgct caatagctgc
    41521 cgcatcatgg tcacccatca tgtcgaaacg aaaaccatct accttgaatt cacgagtcag
    41581 ataagcaatc gaatccacca agatacgacg actcatggca tgtgtcgttc ctagacgacc
    41641 tccgccaaaa ctctctctag ctgtgccatc agcattcata aaatgatagt agttgggttc
    41701 caaatcttca aagagatagg ttctagccgt gtggttataa accacatcaa aaataacacc
    41761 cataccacgt ttgtgaatct cattgacaag gtttttaagc tctgcgatac gtaaagcagg
    41821 gtcgttagga tttaccgaat acatgccaga aagggcaaag tagtgttgtg ggtcataacc
    41881 ccagttgtaa ttattgtctg aagacgtgta ggctgttgag cggctcttgt ccagctcatt
    41941 ggcataaaaa taactcaaaa ccggtagcaa ttgaacgtgg gtaaccccca agtctttgag
    42001 atagtctagc tgttcaacaa aagctgaaaa agtcccaaaa gggtgtgtta acttgccttc
    42061 tagagcctta tccgacgtaa aatctcgcac atgtgcttca tagataatag cgtcttcacg
    42121 ttttttaaag ttgttaattt tggcaaaatc aaggcctgtt ggtcctagtt tgcttggatc
    42181 aataaaggca gcttttgctg ttttgatgtc atcagtagca gtcgcatcat tccaggcagc
    42241 gagagatttg gcgtaaggat ccaaaaccat gactttttcc tgaccgcgcg tgatctcata
    42301 aaggtaatag tagcctgtgt aatcactaat tcccttgaca ctgtcagaag tcagatgagc
    42361 tctccaaaca cccttgtccg acttggtcaa atcagcttga ccaaccacct ttgtctgatc
    42421 ttgtttatcg taaacgacaa ccttaacagt atcagcactt ggagaccata gcgctaaatc
    42481 aacagaacca tccttagcta gggtagctcc aagttcacca tcgtaagcat agagtttatc
    42541 ttttaattgc caggattggc gagcgacttg gctaacttct ccaaatgtaa ccgtgtagac
    42601 tgcaccttgc gccttaaaat cgccctttaa tgtcattaca gacttatcct tgtcaagtgt
    42661 caactcatca attgcaacag ttttccctgc tttgtcagtg atcttgatgt tttgtttcac
    42721 cgcatcttca tcaagcccat ctaaggtcgt aaaaatggct ttaatctcat ttggcgtggt
    42781 ttgttcagct cctttgagac taacctgatc aatataataa ggattgttgt agacttttgg
    42841 gtcagtgtct ttgacaaaaa cttgagtatg attgtctaac tctttaaaca gataatcttt
    42901 tggttgcact ttaatagcat ctcctgtctt acttttatca aggattaaaa atccgatttc
    42961 gttagctcct tcttttaagg ggacatcaac ataagctcca taaggccctt tatgtgacaa
    43021 gtcaagtcca tttggccagt cggtcgttgg gtttttgaca tctttaaagg tccagacagc
    43081 taagttatcg tagtgtcccg attgattgtg gtagttgatt cgaaggtaac cttttttcaa
    43141 aggtcgataa gcgtgcgcat ggtaattctc gtctgtccaa acttcattca tttttggcgt
    43201 aagaagcgag atgtgctggt cctttgaaag attctctcca gctttattat taatgagata
    43261 agacacttgc tggcggtgtt tagctgctag tggcacatct agataatagc catagtcatc
    43321 ttttttcgct tttgtcatgg tgatagcacc atttggccaa tcctttgaag gttgatccac
    43381 atctccccac acccaaagtc ccaagcttcc tagcgactca ccagctggca atgttttaaa
    43441 atgcatacgc aaatgatgct cagcaatact agcaggatta gctgacgagc tgtctaaaac
    43501 tggtttagcc tccttactag acgattgaaa accatcacca gatttagcat tgccatctcc
    43561 ttgttgagct tcatcgcggg ctagtccaac aatggtttta gcagcaactt gatgtgttaa
    43621 gatactaggg gtgcacccta acatgacagt cccagttgca gcgattacaa aacctatccc
    43681 ccactttttt aacagatgtt gatagcgctt tgatccttgg ttgactttct ttttcataag
    43741 acctccattt agtataacat tcaaacaaga ctatcttatc acattgcgca agcgcttgca
    43801 agacatgccg cacttcaact tagaacacag ctcaaacaat gactatcacc ccttaatagg
    43861 atctcaaaaa ttaaacagcc aaaacgagtt tccgctcgct tggctgttgg gtaaactcaa
    43921 atcacataca actgctaggc cttcagtttg agacaaaagg catcccaagg ttgtaagtgc
    43981 ttggtcttta ataccgtgtc cacatctgta ttggcgatga tcacttgtgc acctgctaag
    44041 tctgtggcaa agacttgctc ctcatcagac acattgacaa caatcacata cgtctcttct
    44101 ccaagctgac gctgataagc aaacacttta tcagctgttg gcaagaggtg ataatccgct
    44161 tcaactagcc agtcttgctc cttacgcaag gcaatcaatt tttggtaggt gtaaaaaata
    44221 gagtctggat cagcaagggc atcggccaca ttgatgtctt ggtagttggg gttgaccggc
    44281 aaccaagtct cttttgcttc agaaaagcca gcatgtgtgt ccttagacca ctgcatcggc
    44341 gttctagcat tgtctcgtcc taccttacgg atgctatcca tcacacgcgc agctgacact
    44401 ccatttccca tagcttcctt agcatagtta agggactcaa tatcattaac ctcggttaag
    44461 tctttaaaag gataattggt catgccaatc tcttctcctt ggtaaatgta aggggttcct
    44521 cgcatcaaat gcagtaaaat agctaaagct ttggctgatt tttctcggta agtgctgtca
    44581 ttgccccaaa tggataagac ccgtggcaag tcatggttat tccaaaaaag cgaattccag
    44641 ccttctccta actttaattc tgtctgccac ttgctgaaaa tggttttaag agcagggaca
    44701 tctaattctt tggcataatc ccacttggga gcgtcaggtt tatgttgaag acccacatgc
    44761 tcaaattgga agaccatgga taactctttg ttttcagggc gagaatactg gcgagcaatt
    44821 tcaggcgttg ctccccaagt ctcaccgaca gtcatcacgt catggttgcc aaaggttact
    44881 tgattcattt ctttgaggta atcgtgtaag cgcggcccgt tacccgtgat ttccaagtca
    44941 ggaaccttcc caatcaggtc aatcacgtcc atacgaaaac caccgatgcc tttggcaatc
    45001 cagaaattca tcatatcgta aattttatga cgtaaagctt cattctccca gttgagatct
    45061 ggctgacgtt tgctaaaaag gtgcaaataa tattgacctg atgcattatc atattcccaa
    45121 gctgagccac taaaaataga agtcaaatcg ttaggttcat ctcgccaaat ataaaaatca
    45181 cgctcaggac tattagggtt ttccctagct tcaacaaacc aagcatgctc atcagacgta
    45241 tggttgacca ccaagtccat gataatctta atgccgcgct cattagctgc tgctaagagc
    45301 tcatccatat ctgccatgtc tccaaaaaca tcagcaatcg cttcataatc agagatgtca
    45361 taaccattgt catccattgg actttggtaa acaggagata accaaatggc tgtaatgcca
    45421 agtttttgca agtagtccag ttgactggta atgcctttta aatcaccaat accatttccg
    45481 ctggtgtctt taaaggacct tgggtaaatc tgataaatcg tagctttatg ccaccagtgt
    45541 ttcttcatta ttcttctcct attaatcatt cattcatctt ttattttaac gttttttctc
    45601 tttttatgca atcgtttgcg caaaatgaca tgataaaaag gctggaaccc aaccttttta
    45661 tgaatatcgc ttatacctta acgaatagct tgttcggtat ctctgtcaaa gaaatgccct
    45721 ttagccacat taaaggtcaa gctaacttgc tcccctggac tatggaaatc acgcgcatct
    45781 acacgagaag caaactcagt ttgtccaagc ttgacataga gcatcgtctc agagcccagt
    45841 aactcagaaa ccaaaacttc tgctgtgaca gttgcacttg ggtaagtatc atgcacgatt
    45901 tgtctgctag aaatgtcttc tggacgaata ccaaaagtga cttttttccc cttgtaacca
    45961 gcagcttcaa gcatttttgc ttgaccttca ggaatcgcaa tagcaaggcc atcttcactc
    46021 acaatgcggc catctttaac ttccacttca aagaagttca tggcagggct tccgataaag
    46081 ccggcaacga atttattagc tggaaggttg tacaattctt gtggtgaacc tacttgctca
    46141 attttaccaa tcgttccatt accttgaggg tttttagtgg cactcatgat aacgatacga
    46201 tctgccaaag tcatggcttc agtctggtca tgggtaacgt aaatagttgt tgagccgata
    46261 cgacggtgaa ttttagcaat ttcagcacgc atggagacac gaagcttcgc atccaagttt
    46321 gacaaaggct cgtccatcaa gaatacctta gcatcacgga caatagcacg tcccatagcc
    46381 acacgctgac gttgaccacc agacaggtca gccggtttac gctctagaaa ttcggtcaaa
    46441 ccaaggatct gcgcagcttc cttgacacga cggtcaatat catctttttt gtacttacgt
    46501 aatttcaaac caaaggccat gttatcatac acggtcatgt gtgggtaaag ggcgtagttt
    46561 tgaaagacca tggcaatatc acggtcttta ggagacttgt cattcaccac ttcgccaccg
    46621 atttttaact ctccttcaga aatgtcctca agacctgcaa tcatacgaag agtggttgat
    46681 ttaccacatc ctgaaggtcc aacaaagacg ataaattctt tatctttgat gtccaagtca
    46741 aaatcttcaa cggcataatg agtagtattt gggtattttt tatagatgtg atttagattt
    46801 aattcaacca tgtataactc ctatttagcc agcaaacgtt ctagctgact gcaaagctag
    46861 aaaccgctga tatcttttat atgatgcttt tattataaca aaaatagcgc tttcaaaaca
    46921 gagacaaagc gaccaaactt ctttgggcaa cttgcacaat agcagggcta gtcaagtcgt
    46981 aagggaccat aaaccaagaa aaccatgtaa acacaggcca gtcacaggag ccaaaacaag
    47041 ctgaacgatc tatcattctc cttatcagct acagtccagg cagcaaaaaa gaaagccctg
    47101 tggctttcct aatatttcaa caaaaagaga tgagcaaagg ctaaatcatc caattgcttc
    47161 aagtgtagtc ctgattgctg agcaaattta tcaagtttgt attgcaggga gttacggtga
    47221 atatacaagc gctgcgctgt ctgcaccaga ttgccgtgtt ctgaccatag cgcgtgaacc
    47281 acatcggcca tatcactttg aggacttagg aattggtgaa actgacgcgt caatgccaaa
    47341 aaagtgtggt gcgacagcaa agaccacagc atcagtcctg aaaatgttaa taattttctg
    47401 cctgattgtt gccttaaata ggccgttaac agctgacatt cctcctcaaa acactctctc
    47461 aatgtacccg cagctacttg ataccaggca tttccaacaa acatggttaa ggccaaacca
    47521 aaatcacttt ctagcgttgg caagagacct tcaagcgagc gcaagacctt tattgaagtt
    47581 gcttgtcgac ataaaaatgc tgtttgggtt gtgctgatag gcaaaatgac ctcaagccct
    47641 gcaatcatct gctggagcaa ctcaactaag tcagctggta aaacctgctg atgattgagg
    47701 taaataaact gagaagtctc aaacagctga gggggattgc cctgatgatc aagcaaatac
    47761 cgctgccaag gtgaccctag cggctgcaag acctcacact gacccagccc cacctcaagt
    47821 aataagcgct ctttttcgga taaacatgat ttgggaaaat gcacatattg gtccccttct
    47881 ttgacactca cccactcttt atctcctaac ggatgagggc ctacttgcat ctctggaaaa
    47941 tagtctttta gctccatagc gattcctttc atgacggtct ttaaaccatt ataacacatg
    48001 actctttatc acacagttcg gtttgttgtc agcacgattt tgtatttttt gactttttaa
    48061 tcattaaaac taaataatgg ttattcattt ttagcaataa cattcaatca aatagctatt
    48121 tatcggaaga ttaatttatg tttatactaa aacaggtatt gtttctcttt tttcat
//
LOCUS       DAUDWO010000011        47691 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.011, whole genome shotgun sequence.
ACCESSION   DAUDWO010000011 DAUDWO010000000
VERSION     DAUDWO010000011.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 47691)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 47691)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..47691
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.011"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(122..1141)
                     /gene="ideS"
                     /locus_tag="VHC05_000567"
                     /pseudo
     CDS             complement(122..1141)
                     /gene="ideS"
                     /locus_tag="VHC05_000567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922160.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="immunoglobulin G-degrading enzyme IdeS"
     gene            1640..1890
                     /locus_tag="VHC05_000568"
                     /pseudo
     CDS             1640..1890
                     /locus_tag="VHC05_000568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051153.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            2044..2424
                     /locus_tag="VHC05_000569"
     CDS             2044..2424
                     /locus_tag="VHC05_000569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1149 family protein"
                     /protein_id="HEQ5401902.1"
                     /translation="MQLVREKEFVNQYHYDARNLEWEKENGTPETNFEVTFQLIDKDE
                     QQKETVIVSVLQFVIVKEEFVISGVISQMVRILDRLVDKPSEFTQEEVESLAAPLLDM
                     VKRLTYEVTEIALDRPGIHLEFKN"
     gene            2424..3272
                     /locus_tag="VHC05_000570"
     CDS             2424..3272
                     /locus_tag="VHC05_000570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEQ5401903.1"
                     /translation="MKLAVITDSTATLPTDLKQDKAIFSLDIPVIIDDETYFEGRNLS
                     IDDFYQKMADSQNLPKTSQPSLSELDNLLGLLSSKGYTHVIGLFLAGGISGFWQNIQF
                     LAEEHPEIEMAFPDSKITSAPLGSMVKNVLDWSRQGMTFQAILNKLQEQIDGTTAFIM
                     VDDLNHLVKGGRLSNGSALLGNLLSIKPILRFDEEGKIVVYEKVRTEKKAMKRLVEIL
                     NDLIADGQYNVSIIHSKAQDKADYLKRLLQDSGYQYDIEEVHFGAVIATHLGEGAIAF
                     GVTPRL"
     gene            3397..4605
                     /locus_tag="VHC05_000571"
     CDS             3397..4605
                     /locus_tag="VHC05_000571"
                     /EC_number="2.7.7.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="HEQ5401904.1"
                     /translation="MKLMTMPSEFQKALPILTKIKEAGYEAYFVGGSVRDVLLERPIH
                     DVDIATSSYPEETKAIFNRTVDVGIEHGTVLVLENGGEYEITTFRTEDVYVDYRRPSQ
                     VSFVRSLEEDLKRRDFTVNALALDENGQVIDKFRGLIDLEQKRLRAVGKAEERFEEDA
                     LRIMRGFRFAASLDFDIEAATFEAMRSHSPLLEKISVERSFTEFDKLLMAPHWRKGIS
                     AMIACQAYDYLPGLKQREAGLNHLIVSLKDNFTFSDHHQAWAYVMISLAIEDPKSFLK
                     AWKTSNDFQRYVTKLIALYRIRQERSFEKLDIYQYGKEMASLVEGLRKAQSLSVDMDH
                     IEALDQALAIHNKHDIVLNGSHLIKDFGMEPGPQLGLMLEKVELAIVEGCLDNDFTTI
                     EAFVREELAT"
     gene            4602..6479
                     /locus_tag="VHC05_000572"
     CDS             4602..6479
                     /locus_tag="VHC05_000572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEQ5401905.1"
                     /translation="MSHFLVEKLTKTVGDKTVFQDISFIIHDFDRIGIIGVNGTGKTT
                     LLDVLSGRLGFDGDHSPFSKANDYKIAYLTQDPEFNDASSVLDTVLSSDVKAIQLIRQ
                     YELLMANYTEDKQETLESLMSEMDRLDAWSIESDVKTVLSKLGITDLEQKVGDLSGGM
                     RRRVQLAQVLLGAADLLLLDEPTNHLDIDTIAWLTTYLKTAKKPVLFITHDRYFLDHV
                     ATRIFELDKAGLTEYQGNYQDYVRLKAEQDERDAANLHKKKQLYKQELAWMRTQPQAR
                     ATKQQARINRFTDLKKEVHQDSSADKLEMAFETSRIGKKVIHFEDLSFAYGDRQLIKD
                     FNLIIQNKDRIGIVGDNGVGKSTLLNIINGDLKPTSGKLDIGDTIRVGYFSQQLKDMD
                     ETKRVINYLQEVADEVKTSVGTTSISELLEQFLFPRSSHGTLIAKLSGGEKKRLYLLK
                     LLIEKPNVLLLDEPTNDLDIATLTVLENFLANFAGPVITVSHDRYFLDKVATKILAFE
                     EGDIRIFYGNYSDYLDEKAFEKETVEADLAKAIVTEEVPLSPKEEKKRMSYLEKQEWA
                     QIEDKIATIEANIEEIENQMLTVVSDYGQLAQLQKELDQRNNDLLLAYERFEYLSGLD
                     I"
     gene            complement(6577..6654)
                     /locus_tag="VHC05_000573"
                     /pseudo
     CDS             complement(6577..6654)
                     /locus_tag="VHC05_000573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611513.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            7369..7779
                     /locus_tag="VHC05_000574"
     CDS             7369..7779
                     /locus_tag="VHC05_000574"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HEQ5401906.1"
                     /translation="MIREIITDHFLLKQKAQVAKKEDLWIGQDLQDTLAFYRQECLGM
                     AANMIGEQKRIVIVSMGFIDLVMFNPVMVSKKGIYQTKESCLSLSGYRKTQRYDKITV
                     EYLDHNWRPKRLNLTGLTAQICQHELDHLEGILI"
     gene            complement(7861..9891)
                     /locus_tag="VHC05_000575"
     CDS             complement(7861..9891)
                     /locus_tag="VHC05_000575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional metallophosphatase/5'-nucleotidase"
                     /protein_id="HEQ5401907.1"
                     /translation="MRRFYEKYFILKSSVLSILTSFTLLVTDVQADQVDVQFLGVNDF
                     HGALDNTGTAYTPSGKIPNAGTAAQLGAYMDDAEIDFKQANQDGTSIRVQAGDMVGAS
                     PANSALLQDEPTVKVFNKMKFEYGTLGNHEFDEGLDEFNRIMTGQAPDPESTINDITK
                     QYEHEASHQTIVIANVIDKKTNDIPYGWKPYAIKDIAINDKIVKIGFIGVVTTEIPNL
                     VLKQNYEHYQFLDVAETIAKYAKELQEQHVHAIVVLAHIPATSKDGVVDHEMATVMEK
                     VNQIYPEHSIDIIFAGHNHQYTNGTIGKTRIVQALSQGKAYADVRGTLDTDTNDFIKT
                     PSANVVAVAPGIKTENSDIKAIINHANDIVKTVTERKIGTATNSSTISKTENIDKESP
                     VGNLVTTAQLTIAKKTFPTVDFAMTNNGGIRSDLVVKNDRTITWEAAQAVQPFGNILQ
                     VIQMTGQHIYDVLNQQYDENQTYFLQMSGLTYTYTDNDPKNSDTPFKIVKVYKDNGEE
                     INLTTTYTVVVNDFLYGGGDGFSAFKKAKLIGAINTDTEAFITYITNLEASGKTVNAT
                     IKGVKNYVTSNLESSTKVNSAGKHSIIIISKVFRNRDGNIVSSEIISDLLTSTENTNN
                     SFGKKEITTNKNTISNSTLPITGDNYKMSPIMTILALISLGGLNAFIKKRKS"
     gene            10098..10748
                     /locus_tag="VHC05_000576"
     CDS             10098..10748
                     /locus_tag="VHC05_000576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="HEQ5401908.1"
                     /translation="MKERLEHYSTSSIYSGFEVYLPLVLQTITDVIIAENIKSKKETG
                     FKLYEHFTSRIKSEASMIEKCQRKQLPLTSKSALKIIKDSIGIRIICGFIDDIYRMVD
                     LLKSIPGMSVNAEKDYILNAKPNGYRSYHLILELETHFPDILGEKKGCYFIEVQLRTI
                     AQDSWASLEHQMKYKHQVANAEMITRELKRCADELASCDVTMQTIRQLIQETTEEE"
     gene            10751..11419
                     /locus_tag="VHC05_000577"
     CDS             10751..11419
                     /locus_tag="VHC05_000577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5401909.1"
                     /translation="MKILLAEDEWQMSNVLTTAMTHQGYDVDVVFNGQEAIDKAKDNA
                     YDIMILDIMMPIKSGIEALKEIRASGNCSHIIMLTAMAEINDRVTGLDAGADDYLTKP
                     FSLKELLARLRSMERRVESFTPQVLQFAGVTLNINEQELSAGNAIRLASKEGKLMAFL
                     MLNQGKYLDTKTLYQHVWSDQEDYDTSIVWVYISYLRQKLLAIQANVIIAGDKDTSYC
                     LLEK"
     gene            11428..12660
                     /locus_tag="VHC05_000578"
     CDS             11428..12660
                     /locus_tag="VHC05_000578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HEQ5401910.1"
                     /translation="MFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEINRIL
                     HLISSNKGKLPDTTESSKRLGTKLSEDSLSQFRYYSVIFNANGHLLSSNTANISALDR
                     EEAQYFARLFAKSGEEKGSYRHQDSVYSYLITQLPNEEKLVVILDTTFYFRSVGDLLA
                     VSMMLAFGGFIFFVVLVSLFSGMVIKPFVQNYEKQRRFITNAGHELKTPLAIISANNE
                     LVELMTGESEWTKSTSDQVKRLTGLINQMITLARLEEQPDVVLHMVDFSAIAQDAAED
                     FKSLVLKDGKRFDLTIQPNIMIKAEEKSLFELVTILVDNANKYCDPKGLVKVSLTTIG
                     RRRKRAKLEVSNTYLEGKSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLFK
                     GTITVNYKNDAIVFTVVI"
     gene            12954..13832
                     /gene="mvk"
                     /locus_tag="VHC05_000579"
     CDS             12954..13832
                     /gene="mvk"
                     /locus_tag="VHC05_000579"
                     /EC_number="2.7.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mevalonate kinase"
                     /protein_id="HEQ5401911.1"
                     /translation="MNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFP
                     ADKPLVFDFYDTLSTAIYAALDYLQRLQEPIAYEIVSQVPQKRGMGSSAAVSIAAIRA
                     VFSYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIAL
                     NGYLIIADTGIHGHTREAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQL
                     MTQAHSALKAIGVSISKADQLVEAALRAGALGAKMTGGGLGGCMIALADTKDMAEKIS
                     HRLKEEGAVNTWIQML"
     gene            13814..14758
                     /gene="mvaD"
                     /locus_tag="VHC05_000580"
     CDS             13814..14758
                     /gene="mvaD"
                     /locus_tag="VHC05_000580"
                     /EC_number="4.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="HEQ5401912.1"
                     /translation="MDPNVITVTSYANIAIIKYWGKENQAKMIPSTSSISLTLENMFT
                     TTSISFLPDTATSDQFYINGVLQNDEEHTKISAIIDQFRQPGQAFVKMETQNNMPTAA
                     GLSSSSSGLSALVKACDQLFNTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAI
                     YKVETDLKMAMIMLVLNAAKKPISSREGMKLCRDTSTTFDEWVEQSAIDYQHMLTYLK
                     TNNFEKVGQLTEANALAMHATTKTANPPFSYLTKESYQAMEAVKELRQEGFACYFTMD
                     AGPNVKVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV"
     gene            14751..15758
                     /locus_tag="VHC05_000581"
     CDS             14751..15758
                     /locus_tag="VHC05_000581"
                     /EC_number="2.7.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomevalonate kinase"
                     /protein_id="HEQ5401913.1"
                     /translation="MSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAA
                     HIQLASDMFAHKAGMTPDASYALIQATVKTFADYLGQSIDQLEPFSLIITGKMERDGK
                     KFGIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQGDNGSMGDIACIAYQT
                     LVAYTSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQM
                     IQQVTASITPAFLRTSYQLTQSAMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKL
                     VTLVAACQKQDAVAKSSGSGGGDCGIALAFNQDARDTLISKWQEADIALLYQERWGEN
                     D"
     gene            15751..16740
                     /locus_tag="VHC05_000582"
     CDS             15751..16740
                     /locus_tag="VHC05_000582"
                     /EC_number="5.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="HEQ5401914.1"
                     /translation="MTNRKDDHIKYALKYQSPYNAFDDIELIHHSLPSYDLSDIDLST
                     HFAGQDFDFPFYINAMTGGSQKGKAVNEKLAKVAAATGIVMVTGSYSAALKNPNDDSY
                     RLHEVADNLKLATNIGLDKPVALGQQTVQEMQPLFLQVHVNVMQELLMPEGERVFHTW
                     KKHLAEYASQIPVPVILKEVGFGMDVNSIKLAHDLGIQTFDISGRGGTSFAYIENQRG
                     GDRSYLNDWGQTTVQCLLNAQGLMDQVEILASGGVRHPLDMIKCFVLGARAVGLSRTV
                     LELVEKYPTERVIAIVNGWKEELKIIMCALDCKTIKELKGVDYLLYGRLQQVN"
     gene            complement(16970..18247)
                     /locus_tag="VHC05_000583"
     CDS             complement(16970..18247)
                     /locus_tag="VHC05_000583"
                     /EC_number="1.1.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA reductase,
                     degradative"
                     /protein_id="HEQ5401915.1"
                     /translation="MTKTNLNWSGFSKKTFEERLQLIEKFKLLNAENLNQLKTDVLLP
                     IQTANQMTENVLGRLALPFSIAPDFLVNGSTYQMPFVTEEPSVVAAASFAAKLIKRSG
                     GFKAQTLNRQMIGQIVLYDIDQIDNAKAAILHKTKKLIALANKAYPSIVKRGGGARTI
                     HLEEKGEFLIFYLTVDTQEAMGANMVNTMMEALVPDLTRLSKGHCLMAILSNYATESL
                     VTTSCEIPVRLLDRDKTKSLQLAQKIELASRLAQVDPYRATTHNKGIFNGIDAVVIAT
                     GNDWRAIEAGAHAYASRNGSYQGLSQWHFDQDKQVLLGQMTLPMPIASKGGSIGLNPT
                     VSIAHDLLNQPDAKTLAQLIASVGLAQNFAALKALTSSGIQAGHMKLHAKSLALLAGA
                     TQDEIAPLVNALLADKPINLEKAHFYLSQLRQS"
     gene            complement(18234..19409)
                     /locus_tag="VHC05_000584"
     CDS             complement(18234..19409)
                     /locus_tag="VHC05_000584"
                     /EC_number="2.3.3.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="HEQ5401916.1"
                     /translation="MTIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSV
                     APITEDIITLAASAADQILTDEDRAKIDMVILATESSTDQSKASAIYVHHLVGIQPFA
                     RSFEVKQACYSATAALDYAKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIAL
                     LVTANPRILALNKDNVAQTRDIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQK
                     RENLQLSDFAAVCFHIPFPKLALKGLNNIMDNTVPPEHREKLIEAFQASITYSKQIGN
                     IYTGSLYLGLLSLLENSKVLQSGDKIGFFSYGSGAVSEFYSGQLVAGYDKMLMTNRQA
                     LLDQRTRLSVSKYEDLFYEQVQLDDNGNANFDIYLTGKFALTAIKEHQRIYHTNDKN"
     gene            19618..20457
                     /locus_tag="VHC05_000585"
     CDS             19618..20457
                     /locus_tag="VHC05_000585"
                     /EC_number="2.1.1.45"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003011065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidylate synthase"
                     /protein_id="HEQ5401917.1"
                     /translation="MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAF
                     AEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQT
                     RTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMF
                     DVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNL
                     HIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFD
                     LAI"
     gene            20537..21034
                     /locus_tag="VHC05_000586"
     CDS             20537..21034
                     /locus_tag="VHC05_000586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase"
                     /protein_id="HEQ5401918.1"
                     /translation="MTKEIIAIWAEDEAGLIGVAGKLPWYLPKELEHFKKTTLHQAIL
                     MGRVTFEGMNCKRLPQRQTLVMTRNRDYQVDEVLTMTSIEKVLEWYHAQDKTLYIIGG
                     NKVLEAFNGYFDRIIKTVIHHRFKGDTYRPHLDFSHFTQESQTFYARDAKNPYDFTVT
                     ALKHK"
     gene            21054..21224
                     /locus_tag="VHC05_000587"
     CDS             21054..21224
                     /locus_tag="VHC05_000587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002302775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401919.1"
                     /translation="MQRSIFGVFTAFLCVICVLCAIPAFKKNRYGLASLFLLNAFTNL
                     VNSIHAFYGTLF"
     gene            21354..22583
                     /gene="clpX"
                     /locus_tag="VHC05_000588"
     CDS             21354..22583
                     /gene="clpX"
                     /locus_tag="VHC05_000588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="HEQ5401920.1"
                     /translation="MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQE
                     IIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDRAKRALSVAVYNHYKRVSFTESR
                     DDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
                     LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTV
                     ASVPPQGGRKHPNQEMIQIDTKNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKID
                     DNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQILTEPRNALVKQYQA
                     LLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVR
                     ITKAAVEGKSKPVLETA"
     gene            22593..23192
                     /locus_tag="VHC05_000589"
     CDS             22593..23192
                     /locus_tag="VHC05_000589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihA family ribosome biogenesis GTP-binding
                     protein"
                     /protein_id="HEQ5401921.1"
                     /translation="MAEEQVLNTHNASILLSAANKSHYPQDDLPEIALAGRSNVGKSS
                     FINTILGRKNLARTSSKPGKTQLLNFFNIDNKLRFVDVPGYGYAKVSKSERAKWGKMI
                     EEYLTSRDNLRAVVSLVDLRHAPSKEDIQMYDFLKYYDIPVIVVATKADKIPRGKWNK
                     HESVVKKALNFDKSDTFIVFSSVERIGIDDSWDAILEQV"
     gene            23340..24083
                     /locus_tag="VHC05_000590"
     CDS             23340..24083
                     /locus_tag="VHC05_000590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401922.1"
                     /translation="MTQVAQGRSKGKSLLCHQCNALFVFIIFLILLAVLFGVRYRNSS
                     IEGIWRTTSIDQKLGDDFAKRLTGLHQSPLIDDSLLTSSQMILTVKNNNVDLSFSVQV
                     ERDIFVKRLAAYHQNELLKTLKENHLVVGDLSSKERQIIENSMPASHELEMILDQAFE
                     KLASQIGGKYNQKTGHLSAVVLKGKVNRILHTIDIKEEVAAGHTSFSKGLLTPNGYFD
                     YTRFGKKLELLGDEKIIFKKVLKKSPSSV"
     gene            complement(24141..26240)
                     /locus_tag="VHC05_000591"
     CDS             complement(24141..26240)
                     /locus_tag="VHC05_000591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEQ5401923.1"
                     /translation="MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPE
                     EFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLGTNLTQEARQGHLDPVIGRNKEI
                     QDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
                     EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKP
                     ALSRGELTLIGATTQDEYRNTILKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQ
                     HHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAAQHPVTDLKTLETEI
                     AKQKERQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQTQNVTATVNDIAESVERLTG
                     IPVSNMGTNDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLF
                     VGPTGVGKTELAKQLALDLFGSKDAIIRLDMSEYNDRTAVSKLIGTTAGYVGYDDNNN
                     TLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNTVIIATS
                     NAGFGQQDTETSGFNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVN
                     QTTAKKGISLTIADDAKAHLIDLGYNRAMGARPLRRIIEQEIRDRITDYYLDHPEVKK
                     LQAILKEGQLVIRQNDQ"
     gene            26618..27301
                     /gene="rpiA"
                     /locus_tag="VHC05_000592"
     CDS             26618..27301
                     /gene="rpiA"
                     /locus_tag="VHC05_000592"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009881270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-5-phosphate isomerase RpiA"
                     /protein_id="HEQ5401924.1"
                     /translation="MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQE
                     GLQVVGVTTSSVTSKQAEGLGIPLKSIDDIDSIDLTVDGADEVDKDFNGIKGGGAALL
                     MEKIVATPTKEYIWVVDASKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMK
                     GDSRLVTDMQNYIIDLDLGCIKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGV
                     TVLEAPKAG"
     gene            27378..28589
                     /locus_tag="VHC05_000593"
     CDS             27378..28589
                     /locus_tag="VHC05_000593"
                     /EC_number="5.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopentomutase"
                     /protein_id="HEQ5401925.1"
                     /translation="MSKFNRIHLVVLDSVGIGAAPDADKFFNAGVADTDSDTLGHISE
                     TAGLSVPNMAKIGLGNISRPIPLKTIPTEDNPTGYVTKLEEVSLGKDTMTGHWEIMGL
                     NITEPFDTFWNGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPRQMETGELIV
                     YTSADPVLQIAAHEDIIPVEELYKICEYARSITLERPALLGRIIARPYVGEPGNFTRT
                     ANRHDYAVSPFQDTVLNKLADAGVPTYAVGKINDIFNGSGITNDMGHNKSNSHGIDTL
                     IKTLQLPEFTKGFSFTNLVDFDANFGHRRDPEGYRDCLHEFDNRLPEIIANMKEDDLL
                     LITADHGNDPTYAGTDHTREYIPLLAYSASFTGNGLIPQGHFADISATVAENFGVDTA
                     MIGESFLGHLK"
     gene            28608..29048
                     /gene="arsC"
                     /locus_tag="VHC05_000594"
     CDS             28608..29048
                     /gene="arsC"
                     /locus_tag="VHC05_000594"
                     /EC_number="1.20.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922177.1"
                     /note="This arsenate reductase requires both glutathione
                     and glutaredoxin to convert arsenate to arsenite, after
                     which the efflux transporter formed by ArsA and ArsB can
                     extrude the arsenite from the cell, providing resistance;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase (glutaredoxin)"
                     /protein_id="HEQ5401926.1"
                     /translation="MEEITIYHNPNCGTSRNVLAMIRHAGIEPTIIEYLQTPPNRETL
                     IELLQSMGISARELLRTNVPEFEAHGLANQAVAEKDVINAMLTDPILINRPIVVTRKG
                     VKLCRPSETLLDILPVPLPSPYIKEDGEIVNPIEVKGEKDVIDD"
     gene            29032..29841
                     /locus_tag="VHC05_000595"
     CDS             29032..29841
                     /locus_tag="VHC05_000595"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015647060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HEQ5401927.1"
                     /translation="MSLMTKINETKDFLVAKGIEAPEFGLILGSGLGELAEEVENAIV
                     IDYADIPNWGKSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPLEVVTFPVRVMKA
                     LGCEGVLVTNAAGGIGYGPGTLMAITDHINMTGNNPLIGENLDEFGPRFPDMSDAYTK
                     VYRNKAHEVAEKMNIKLEDGVYMGLTGPTYETPAEIRAFKVLGADAVGMSTVPEVIVA
                     AHSGLKVLGISAITNFAAGFQSELNHEEVVEVTQHIKEDFKGLVKAILSEL"
     gene            30504..31217
                     /gene="deoD"
                     /locus_tag="VHC05_000596"
     CDS             30504..31217
                     /gene="deoD"
                     /locus_tag="VHC05_000596"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HEQ5401928.1"
                     /translation="MSIHISAKKGDIADKILLPGDPLRAKFIAENFLEDAVCFNEVRN
                     MFGYTGTYKGHRVSVMGTGMGMPSISIYARELIVDYGVKTLIRVGTAGAIDPEVHVRE
                     LVLAQAAATNSNIIRNDFPEFDFPQIADFGLLDKAYHIAREMGVTTHVGNVLSSDVFY
                     TNMPERNMVLGKLGVKAIEMEAAALYYLAAQHHVKALGIMTISDNLNDPTEDTTAEER
                     QTTFTDMMKIGLETLIAND"
     gene            31210..31998
                     /locus_tag="VHC05_000597"
     CDS             31210..31998
                     /locus_tag="VHC05_000597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytR family transcriptional regulator"
                     /protein_id="HEQ5401929.1"
                     /translation="MTNNQTLDILLDVYAYNHVFRIAKALPNIPKTVLYLLEMLKERR
                     ELNLAFLVEHAAENRTIEDQYHCSLWLNQSLEDEQIANYILDLEVKVKNGAIIDFVRS
                     VSPILYRLFLRLITSEIPNFKAYIFDTKNDQYDTWHFQAMLESDHEVFKAYLSQKQSR
                     NVTTKSLADMLTLTSLPQEIKDLVFLLRHFEKAVRNPLAHLIKPFDEEELHRTTHFSS
                     QAFLENIITLATFSGVIYRREPFYFDDMNAIIKKELSLWRQSIV"
     gene            complement(32078..32983)
                     /locus_tag="VHC05_000598"
     CDS             complement(32078..32983)
                     /locus_tag="VHC05_000598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEQ5401930.1"
                     /translation="MRIQQLHYIIKIVECGSMNEAAKQLFITQPSLSNAVKDLEMEMG
                     ITIFNRNPKGITLTKDGVEFLSYARQIIEQTSLLEDRYKNHNTGRELFSVSSQHYAFV
                     VNAFVSLLKRTDMTRYELFLRETRTWEIIDDVKNFRSEIGVLFINDYNRDVLTKLFDD
                     NHLTASPLFKAQPHIFVSKSNPLATKSLLSMDDLRDFPYLSYDQGIHNSFYFSEEMMS
                     QMPHNKSIVVSDRATLFNLMIGLDGYTVASGILNSNLNGDQIVAIPLDVPDEIDIVFI
                     KHEKANLSKMGERFIEYLLEEVTFD"
     gene            33205..33741
                     /locus_tag="VHC05_000599"
     CDS             33205..33741
                     /locus_tag="VHC05_000599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401931.1"
                     /translation="MNVTEQNSHQILIQKLLVSIHYLTLFRDELKLVERTPSILGGEF
                     PAHLVQSELGDIVAAIDTLDMQQRLIESTFWYEESAFKLMNKTLDIVDNWIKGVDHLI
                     DLCQSKEVFQIIIGDKRIRVFGVLSDVFSSLKVSALSLKEAPIPDLLYEHIQRVNLEE
                     EAFIKYYQGPKVPTGEFE"
     gene            34018..34710
                     /gene="pyrF"
                     /locus_tag="VHC05_000600"
     CDS             34018..34710
                     /gene="pyrF"
                     /locus_tag="VHC05_000600"
                     /EC_number="4.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="HEQ5401932.1"
                     /translation="MKEERPIIALDFSSFEETKAFLDLFPAEEKLYVKIGMELYYAQG
                     PDIVRYIKSLGHNVFLDLKLHDIPNTVRAAMAVLKELDIDMATVHAAGGVEMLKAARE
                     GLGQGPTLIAVTQLTSTSEDQMRGDQNIQTSLLESVLHYSKGAAKAQLDGVVCSAQEV
                     EAIKAVTPTGFTCLTPGIRPKGSNIGDQKRVMTPNQARRIGSDYIVVGRPITQAKDPV
                     AAYQAIKAEWAG"
     gene            34768..35397
                     /locus_tag="VHC05_000601"
     CDS             34768..35397
                     /locus_tag="VHC05_000601"
                     /EC_number="2.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="HEQ5401933.1"
                     /translation="MTLASQIATQLLDIKAVYLKPEDPFTWASGIKSPIYTDNRVTLS
                     YPKTRDLIENGFVETIRAHFPEVEVIAGTATAGIPHGAIIADKMTLPFAYIRSKPKDH
                     GAGNQIEGRVLKGQKMVIIEDLISTGGSVLDAAAAASREGADVLGVVAIFTYELPKAS
                     QNFKEAGIKLITLSNYTELIAVAKLQGYITNDGLHLLKKFKEDQVNWQQ"
     gene            35594..37048
                     /locus_tag="VHC05_000602"
     CDS             35594..37048
                     /locus_tag="VHC05_000602"
                     /EC_number="3.5.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidase"
                     /protein_id="HEQ5401934.1"
                     /translation="MTYQDATAMAIAVQTGQTTPLELVTQAIYKAKKLNPTLNAITSE
                     RFEAALEEAKQRDFSGLPFAGVPIFLKDLGQELKGHSSTSGSRLFKEYQATKTDLFVK
                     RLEALGFIILGRSNTPEFGFKNISDSSLHGPVNLPKDNTRNAGGSSGGAAALVSSGIS
                     ALAPASDGGGSIRIPASFNGLIGLKPSRGRMPVGPGSYRSWQGASVHFALTKSVRDTR
                     NLLYYLQMEQMESPFPLATLTKDSIYQSLQRPLTIAFYQRLSDGSPVSLDTAKALKQA
                     VTWLREQGHQLVELEEFPVNMTEVIRHYYIMNSVETAAMFADIEDTLGRPMTKDDMET
                     MTWAIYQSGKDIPAWRYSQVLQKWDTYSATMASFHETYDLLLTFTTNTPAPKHGELVP
                     DSKLMANLAQAEIFSSEEQFNLVETMFGKSLAINPYTALPNLTGQPAISLPTYETKEG
                     LPMGIQLIAAKGREDLLLGIAEQFEAAGLLKIPQ"
     gene            37166..38029
                     /locus_tag="VHC05_000603"
     CDS             37166..38029
                     /locus_tag="VHC05_000603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEQ5401935.1"
                     /translation="MKKSVTLLSIGLASLLLAACAPHKSQKSSWETIKEKGVLKVATP
                     GTYQPTSFYNDNNELVGYEVDMVKEIGKRLNIKVKFVETGFDQAFTSVDSGRVDISLN
                     NFDITPKRQKKYNISTPYKYGVGGMIVRADGSSNMVKKDLSDWKGKKAAGASGTEYMK
                     VAQKQGAELVTYDNVTGDVYLNDVANGRTDFIPNDYPAQKLFVDYMLSQNPNLNVKMS
                     DVQYNPTEQGIVMNKKDDSLKKKIDAVIKDMIKDGSLKKISETYYAGQDLTKPFGKDK
                     KIPVIDTKDVN"
     gene            38058..38708
                     /locus_tag="VHC05_000604"
     CDS             38058..38708
                     /locus_tag="VHC05_000604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003057640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEQ5401936.1"
                     /translation="MINIPLMKDSLGFVLSGLPYTLGISLLSFFTGLFLGLGLALLGR
                     SRQPLIHYLVRAYISIMRGVPMIVVLFVLYFGLPYYGLELPALLCAYLGFSMVSAAYI
                     SEVFRSSIEAIDKGQWEAAKALGLPYALMVKKIILPQAFRIAVPPLGNVIIDMVKSSS
                     LAAMITVPDIFQNAKIIGGREWDYMSMYILVAFIYWLIAFLLERYQEFLENKLALV"
     gene            38841..39494
                     /locus_tag="VHC05_000605"
     CDS             38841..39494
                     /locus_tag="VHC05_000605"
                     /EC_number="3.2.2.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase"
                     /protein_id="HEQ5401937.1"
                     /translation="MTHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPQRENVFK
                     ALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRD
                     HHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWG
                     AYARKKKAFITNSKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK"
     gene            39626..40894
                     /locus_tag="VHC05_000606"
     CDS             39626..40894
                     /locus_tag="VHC05_000606"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotase"
                     /protein_id="HEQ5401938.1"
                     /translation="MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVI
                     DASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVE
                     TLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
                     KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMI
                     AYDRQAHVHIQHLSKAESVQVVAFAQQLGAKVTAEVSPQHFSTTEDLLLTAGTSAKMN
                     PPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKAVDDMTKAPSGMTGLETSLSLG
                     LTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFV
                     SKASNSPFIGNKLKGVVKYTIADGEVVYPN"
     gene            complement(40952..41593)
                     /gene="plsY"
                     /locus_tag="VHC05_000607"
     CDS             complement(40952..41593)
                     /gene="plsY"
                     /locus_tag="VHC05_000607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009881256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol-3-phosphate 1-O-acyltransferase PlsY"
                     /protein_id="HEQ5401939.1"
                     /translation="MKLLLFITIAYLLGSIPTGLWIGQYFYHINLREHGSGNTGTTNT
                     FRILGVKAGTATLAIDMFKGTLSILLPIIFGMTSISSIAIGFFAVLGHTFPIFANFKG
                     GKAVATSAGVLLGFAPLYLFFLASIFVLVLYLFSMISLASVVSAIVGVLSVLTFPAIH
                     FLLPNYDYFLTFIVILLAFIIIIRHKDNISRIKHHTENLIPWGLNLSKQVPKK"
     gene            41728..43677
                     /gene="parE"
                     /locus_tag="VHC05_000608"
     CDS             41728..43677
                     /gene="parE"
                     /locus_tag="VHC05_000608"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit B"
                     /protein_id="HEQ5401940.1"
                     /translation="MTKKEITINNYNDDAIQVLEGLDAVRKRPGMYIGSTDATGLHHL
                     IWEIVDNAVDEALSGFGDDIKVVINKDGSVSVADSGRGMPTGQHAMGIPTVQVIFTIL
                     HAGGKFGQGGYKTSGGLHGVGSSVVNALSAWLEVEITRDGAVYRQRFENGGKPVTTLK
                     KVGTAPKSKSGTVVTFMPDDKIFSTIDFKFNTISERLKESAFLLKNVKMSLTDLRGDD
                     PIIEEFHYENGVQDFVEYLNEDKETLTPVIYMEGQDQDFQVEVALQYNDGFSDNILSF
                     VNNVRTKDGGSHETGLKSAITKAMNDYARKTNLLKEKDKNLEGSDYREGLSAVLSILV
                     PEQHLQFEGQTKDKLGSPLARPIVESIVSEKLTFFLLENGEVASHLVRKAIKARDARE
                     AARKARDDSRNGKKNKKDKGLLSGKLTPAQSKNAKKNELYLVEGDSAGGSAKQGRDRK
                     FQAILPLRGKVLNTEKAKMADILKNEEINTMVYTIGAGVGADFNLEDINYDKIIIMTD
                     ADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKTEKIAYAWTDGEL
                     EDLRREFGKGAILQRYKGLGEMNANQLWETTMDPETRTLIRVTIDDLARAERRVSVLM
                     GDKAAPRRQWIEDNVKFTLEENTVF"
     gene            43768..46227
                     /gene="parC"
                     /locus_tag="VHC05_000609"
     CDS             43768..46227
                     /gene="parC"
                     /locus_tag="VHC05_000609"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021340535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit A"
                     /protein_id="HEQ5401941.1"
                     /translation="MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRI
                     LYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMH
                     GNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFP
                     NLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGI
                     IQGADEIKKAYETGKGRVVVRSRTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVR
                     VNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDH
                     FTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALI
                     RSSDNKADAKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLS
                     AIIGDEATMYNVMKRELREVKKKFANPRLSELQAESQIIEIDTASLIAEEETFVSVTR
                     GGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYRPIHELT
                     DLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPW
                     RTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGV
                     KGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDDIPQTSRANRGLLVLRELKTK
                     PHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERT
                     SNGSFISDTISDQEVLVARTR"
     gene            46305..47372
                     /locus_tag="VHC05_000610"
     CDS             46305..47372
                     /locus_tag="VHC05_000610"
                     /EC_number="2.6.1.42"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="HEQ5401942.1"
                     /translation="MKKSYNRKKQKRGTMMTIAIDWDNLGFEYHKLPFRYISYYKNGQ
                     WDKGQLTEDATLHISESAPALHYGQQAFEGLKAYRTKDGSIQLFRPDRNAARLQATAD
                     RLLMPQVSTEQFIDAAKQVVKANEDFVPPYGTGATLYLRPLLIGVGGIIGVKPAEEYI
                     FTIFAMPVGNYFKGGLAPTNFIVSEAFDRAAPYGTGAAKVGGNYAGSLLPGKAAKSAG
                     FSDVIYLDPATHTKIEEVGAANFFGITANNEFVTPLSPSILPSITKYSLLQLAEERLG
                     MTVIEGDVPINELDKFVEAGACGTAAVISPIGGIQYKDNLHVFYSETEVGPVTRRLYD
                     ELVGIQFGDIEAPEGWIVKVD"
     gene            47493..>47691
                     /locus_tag="VHC05_000611"
     CDS             47493..>47691
                     /locus_tag="VHC05_000611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEQ5401943.1"
                     /translation="MLHKEKPDYNRNQYGFYTLDQLVPDEHFLRQVEAVIDFDFIYDL
                     VEDTYSSDNGRPSLDPVMLVKI"
BASE COUNT        14969 a         8352 c         9792 g        14578 t
ORIGIN      
        1 gatttttata ggatttatta atgttttttg ctgttgccca tctataaaaa aattccctgc
       61 aatagtatta gtccttagaa taccatcatc tgttgaaggt attctttctt attgatacgc
      121 tttaattggt ctgattccaa ctatcttgcc ctgttgaaag tgtaaataac cctagtactt
      181 gagcaccaat attatcttat tttatttctt tagcagaaat agctactttt ccagcggaat
      241 taacaccaac aaagtatttc ttcataccaa tagatgcatt actatcagag tctgttacat
      301 aaatagcttt aaggttcccg ttagaatcga agtcagctcc ccacaggttt ataacatggt
      361 tgatgcgtac gttagcgtag gtgtgtgata ggcctagagc cttgccttcg gttaactctt
      421 tcttaatgag atcactgatt tctttgagat ttttttcttt aaaatcatga cgacttgtca
      481 atagcttact ttgatcacct cttgtaaata cggcgtcaaa aataccacct cggggatctt
      541 tactaccttc ttttactggc gttggaccgt ggttagttag actaaggcgg tagccgttaa
      601 tgaacatatc aattacatga tcagggaaaa ctcctaggtg tttagcagat agataaggga
      661 aagctttttc tttaaaatat tcaaataatt tactatctag ctggtggttt ttagtgtcga
      721 tagcttcttt tacgtcaaac atctgttcgc cattgaagtt tattttttgc ttgtctggat
      781 gctcttccaa ataacgttta atttggtctt tgttttgatc gaaccaccag tgaagcatat
      841 tccctgctgt ggcagccccg caaagaagat cgtcttttcc attgaatgtt ttggtaatat
      901 cataccatcc ttggttagca acataaggag cgtgaaaaac atcttcgcct tgagtgaagt
      961 ttgctgtagg agtaactcct ttggtccaaa cggaagtaac gtgataaggt gttacttccg
     1021 aatatctaat ctcttgatta gcagaaaaac tatctgctat aacaccacga tctaccgata
     1081 gagcaaataa agtcactgct gccaatactg cagctgaagt tgaatagcat ctttttctca
     1141 taagaatacc tttttctata taattttatg ataaataaat tatataatat agacatatat
     1201 tattgcaagt tcttaaaata atatttaatt ttttaaataa tttttaataa aattaaacaa
     1261 gcgattgcaa tggagacatc acaagagata cagtagtggt tgtgcttaaa aatgaacggt
     1321 tttttgatga tatgttgctg catgaggaag tgagcaatag gagagctgtg atagaagaaa
     1381 gaagggaaga agcgttgatg aaattagaca aataaaaaaa gacctcatcc agaagaggtc
     1441 gtggtataac tggggacgat aggttcaatt gataaaaaat cttgttagct tacgatctat
     1501 gttgttttga atgcctttaa ctcaacatcg ttaatggagt ttgagataaa aaaataaatc
     1561 caatagtctg gtactttcct attttttgtc tgttaaaacg tttttatttt ataatggata
     1621 aaagaagaag ggcggagcga tgattaagcc ctatgggttt aagtatgggt tagttggaga
     1681 ggttttgcgg cggattgaac gcctaggatt tacgtttgag cgactagagc taagacaagc
     1741 tagttcgaaa tacttggcta agcatgatga ggccttggtg ataaaccttt ttatcctgga
     1801 cttaaaactt acctgaccag tggttctgtt ttaattgagg tgcagtacaa gaccactaac
     1861 gggtgttttt ttgatataat gtcagtataa ggacgactaa atataaatag gtgaaaaaat
     1921 agatatctgt tcgagagata gcactgttta aaacgttatg caaaaatagt agtttagggg
     1981 ctactttaat aattttcaaa tctatgctat aatggatcat attgatacca aggagaataa
     2041 aaaatgcaat tagttcgtga aaaagaattt gtcaaccagt accattatga tgctagaaat
     2101 ttagagtggg aaaaagaaaa cggaacacca gagaccaatt ttgaagtgac ttttcagttg
     2161 attgataaag atgagcagca aaaagaaaca gtaattgtat ctgtattgca atttgttatt
     2221 gtcaaagaag aatttgttat tagtggggtc atctcacaaa tggttcgtat tttagatcgt
     2281 ttagtggata aaccaagcga atttacgcaa gaggaagttg aatccttagc tgctcctttg
     2341 ctagatatgg ttaagcgatt gacttatgaa gtcacagaaa ttgccttgga tcgtccaggt
     2401 attcatttgg agtttaaaaa ttaatgaaat tagcagtaat tactgacagt acagcaacac
     2461 taccaacaga tctgaaacaa gataaagcta tttttagcct tgatatacca gttatcattg
     2521 acgatgagac ctattttgaa ggtcgaaatt tgagtataga tgatttttat caaaagatgg
     2581 ctgactccca aaatcttccc aagacaagtc agccaagttt atctgaacta gataatcttt
     2641 taggactttt gtcttctaag ggttatacac atgttattgg cttgttctta gctggaggaa
     2701 tctcaggctt ttggcaaaat attcaatttt tagctgaaga acatcctgag attgaaatgg
     2761 catttccaga cagtaagatc acatctgctc ctttaggtag tatggtaaaa aatgtgctag
     2821 attggtcacg tcaaggaatg acatttcaag ctattttaaa caagctgcaa gaacagattg
     2881 atgggacgac agcctttatt atggttgatg accttaatca tctggttaaa ggcggacgcc
     2941 tgtcaaatgg gtctgctctt cttggaaatc ttttgagtat taaacctatt ttacgctttg
     3001 atgaagaggg aaaaatcgtt gtttatgaaa aagtgagaac agaaaagaaa gccatgaaac
     3061 gcttggttga gattttaaat gacttgatag cagacggtca gtataatgtg tctattattc
     3121 actcaaaagc acaagacaaa gctgattatt tgaaacgact cttacaggac agtggttatc
     3181 aatatgacat tgaagaggtt cattttggag cggtgattgc tactcattta ggagaaggag
     3241 ccattgcatt tggcgtaaca ccgaggcttt aattgtcgat tagaaaaaat agttaattgc
     3301 aagaatcact aaaacaataa caaaatgtga tagaacccaa gtagcttaat cacactttag
     3361 attgggctag ttggatgata ggttagaaaa caacgtatga aattaatgac aatgccttct
     3421 gagtttcaga aggctttacc catattgact aaaataaaag aagctggtta tgaagcctat
     3481 tttgtgggag gaagcgtcag agatgtttta ctcgagcgtc ccattcatga tgtagatatt
     3541 gcaactagtt cctatcctga agagactaaa gcgattttta acagaactgt cgatgttggc
     3601 attgaacatg gcactgtttt ggttttggaa aatggtggtg aatatgaaat tacaaccttt
     3661 aggacagaag atgtctatgt tgattatcgc cgtcctagtc aggtttcttt tgtgcgctct
     3721 ttagaggaag acttaaaacg aagagacttt accgtcaatg ccttggcctt ggatgaaaat
     3781 ggtcaagtta ttgataaatt tagaggactc attgatttgg agcaaaaacg gttacgagca
     3841 gtgggtaaag cagaggaacg ttttgaagaa gatgcactac gcattatgag aggctttcga
     3901 tttgcggcga gtctggattt tgacattgaa gctgcaactt ttgaagctat gaggagccat
     3961 tcacctctat tggaaaagat ttctgtggaa cgttctttta ctgaatttga taaattattg
     4021 atggcaccgc actggcgaaa agggatttct gccatgattg cttgtcaggc ttatgactat
     4081 ttaccaggct tgaagcagcg ggaagcaggc ttgaatcatc tgatagtttc tttgaaagat
     4141 aactttacct ttagtgatca ccaccaagct tgggcttatg tgatgattag tttagccatt
     4201 gaggatccta aaagcttcct aaaagcatgg aagacttcaa atgattttca gcgttatgtc
     4261 acaaagttga ttgctcttta tagaattcgt caggaaagat cttttgaaaa attggatatt
     4321 taccagtacg gcaaggaaat ggcaagtcta gtggaaggcc tccgaaaagc tcaaagctta
     4381 tctgttgaca tggaccacat tgaagcttta gatcaagcgc tagccattca taacaaacac
     4441 gatatcgtcc ttaatggttc tcacctgatt aaggattttg ggatggaacc aggtcctcag
     4501 ctagggctta tgcttgagaa agttgaatta gcgattgtag agggatgcct agataatgat
     4561 ttcactacaa ttgaagcatt tgttagagag gaattagcaa catgagccat tttttggtgg
     4621 agaaattgac aaaaacggtg ggagataaga ccgtctttca ggatatttcc tttattattc
     4681 atgactttga ccgtattggg attattgggg ttaatggaac aggaaaaaca actcttttag
     4741 atgtcttgtc gggaaggctt ggttttgacg gagaccattc accattttct aaagccaatg
     4801 attacaaaat cgcttactta acacaagatc ctgaatttaa cgatgcatcc tctgttttag
     4861 atacggtatt gtcatctgat gttaaggcga ttcagctgat tcgtcagtat gaactattga
     4921 tggcgaatta tactgaagat aaacaagaga ccttagagtc cctcatgtct gaaatggatc
     4981 gcttagatgc ttggtctatt gaaagtgatg tcaaaacagt cctatcaaaa ttaggcatca
     5041 cggatttgga acaaaaagtg ggagacctat caggtggtat gagaagacgt gtccagttag
     5101 ctcaagtatt gctaggagct gctgacttac tcttgttgga tgagccgacc aaccatctcg
     5161 atattgacac catcgcttgg ttaacaacct atctcaagac agctaaaaaa cccgtccttt
     5221 ttattaccca tgaccgttat ttccttgatc atgtggctac ccgtattttt gaattggata
     5281 aagcgggact gacagaatat caaggcaatt accaagacta tgtgcgctta aaagcagaac
     5341 aagacgaacg agatgctgct aatttacaca agaagaagca actctataaa caagaattag
     5401 cttggatgag gacgcagcca caggcgcgtg caactaaaca gcaggctaga atcaatcgtt
     5461 tcactgactt gaaaaaagaa gttcaccaag acagttctgc ggataagttg gagatggctt
     5521 tcgaaacgag ccgaattggg aagaaggtga ttcactttga agacctttct tttgcttatg
     5581 gcgaccgaca gttgattaag gattttaact tgattattca aaataaagat cgtattggaa
     5641 ttgttggaga taacggcgtc ggaaaatcta ccctgttaaa tatcatcaac ggtgatctca
     5701 aaccaacttc tgggaagctt gatattggag atactattcg tgtaggttat ttctctcagc
     5761 agctcaaaga tatggatgag accaaacggg tcattaatta ccttcaagaa gtggctgatg
     5821 aggttaaaac aagcgtggga acaacgagta tcagtgagct tttagagcaa tttctttttc
     5881 cgagatcaag tcatggcacg ctgattgcta aattatctgg tggggagaaa aaacggctct
     5941 acttgctaaa actgctcatt gaaaagccaa atgttcttct ccttgatgag ccaacaaatg
     6001 atttagacat tgccaccttg acggtcttag aaaacttttt agctaacttt gcaggaccag
     6061 tcattacggt tagtcacgat cgttatttcc tagacaaagt agccactaag attttagcct
     6121 ttgaagaagg cgatattcgt attttttatg ggaattacag tgattacctt gatgaaaaag
     6181 cttttgaaaa agaaacagtt gaggctgact tagctaaagc aatagtcact gaagaagtgc
     6241 cactttctcc gaaagaggag aaaaagcgca tgtcctacct tgaaaaacaa gaatgggctc
     6301 agatagaaga taaaatagca actattgagg ctaatattga agaaattgaa aaccaaatgt
     6361 taactgtagt tagtgattat ggccagttag ctcaattaca aaaggaactc gatcagcgca
     6421 ataatgattt attattggcg tatgaacggt ttgagtattt gagtggacta gacatataag
     6481 tatactatgg taatgttatg tttataataa acaagtgata atagaaaaga agtgctcttg
     6541 cactgagccc caaaagttgg ctactctatt tgaagtaaag gatttagttc tgtgttgtag
     6601 aggactaagt ccttttcgtt ttattttgat acggttattg ttgcaataat cgataataat
     6661 agtaggtaga acgagtcaat ttagccgttc ttaaaagaaa atctaatcag aactcgtctt
     6721 tgtccattct ttataatgat tttttgtctt cttcttttca gagatgcttc tttcaaacgg
     6781 agtttcctcg gtttttttag cactaaatat ctagcttatc ttcatagctt aatgtcatgc
     6841 aaaaacaccc caaacgttag atttttttat ctaacgtttg gggtgtagtt tacattatgg
     6901 cgcttctttt ctattattac gtgaggaaaa atcaagtaaa aaagttaagt caactgaaaa
     6961 acttgacaga aatattcaga aaatttataa tactaactat taacaatata tcagttatta
     7021 atgcatttca aacagcaggt gttttatttg gacctgttaa ggctgcaaat gcaagagaaa
     7081 gcagtatctg gtttgaaaat ctcacaaagc aataactatc tctcttagac acttgaagaa
     7141 gcagacagta aactcgataa tattgtgatg agaacttagc aacaatctgc tgatgcaggt
     7201 caatttttat ttggtactca tattgtagaa tttcataaag ttgcccaaga tatcttgaaa
     7261 taaggaatca tctgatgttt taaacagatg atactaagac tatcatatgg tgataatagt
     7321 ccattgaaca tgtagtttat gaattaaaaa aagtttaagg agataagaat gattagagaa
     7381 atcataacag atcatttttt attaaagcaa aaagcacaag tcgccaagaa agaagatcta
     7441 tggattggcc aagatttaca agatacctta gccttttata ggcaggaatg tcttgggatg
     7501 gctgccaata tgattggtga acaaaaacgc attgttattg tgagtatggg atttattgat
     7561 ttggtgatgt ttaatcctgt gatggtttct aaaaagggaa tttaccaaac taaagaatct
     7621 tgtttgtcat tatctggcta tcgcaaaaca cagcggtatg ataagattac tgttgagtat
     7681 ttggaccata attggcgacc aaagcgttta aacttaacag gcctaactgc tcaaatatgc
     7741 cagcacgaat tagatcatct agaaggtatt ttaatttaac aaaaaaccta gagtaggaca
     7801 ctttaggttt ttttggcgaa aatgcctgat tatataagga tgatcaatta ctagtaaacg
     7861 ctaggatttt ctttttttaa tgaaagcgtt tagcccacct aagcttatca aggcaaggat
     7921 tgtcataata ggagacattt tataattgtc ccctgttatt ggaagagtgg aattagagat
     7981 agtatttttg tttgttgtta tctctttttt gccaaagctg ttattagtgt tttcagtaga
     8041 agtcaaaagg tctgaaatga tttcactaga cactatattg ccatcacgat ttctaaaaac
     8101 cttactaatg ataatgatac tgtgtttacc agcactatta acttttgtcg aactttcaag
     8161 gtttgaagtt acataatttt taaccccttt tatagtagca ttaacagttt tacctgatgc
     8221 ttctaaattt gtgatatatg tgatgaaagc ttcagtatct gtgttaatag ctccgattaa
     8281 tttagctttt ttaaatgctg aaaagccatc accaccacca taaagaaagt cgttgacaac
     8341 aacggtgtaa gtagttgtta agttaatttc ttcaccattg tctttataaa ccttaactat
     8401 cttgaagggg gtatcagagt tcttaggatc attatctgta taagtgtatg ttaaacctga
     8461 catttgaaga aaataggtct ggttttcatc gtattgctga tttaggacat cgtaaatgtg
     8521 ttgaccagtc atttgaatga cttgaaggat attaccaaat ggttgtacag cctgtgcagc
     8581 ttcccaggtg atggtccggt catttttgac aactaggtca cttcgaatac caccattatt
     8641 ggtcatagca aagtcaacag ttggaaaagt tttcttagca atagtaagct gagccgttgt
     8701 tactaagtta ccgacaggag attctttatc aatattttct gttttagaaa tagttgaaga
     8761 attagttgca gttccgattt ttcgttcagt aactgtttta acaatatcat tagcatgatt
     8821 tattatagct ttgatatctg aattttctgt tttgatacct ggtgctacag caacaacatt
     8881 tgctgatgga gttttaataa aatcattggt atcagtatct agcgtaccac ggacatctgc
     8941 ataagctttt ccttgagaga gggcttgaac gatacgtgtt ttaccgatag ttccattagt
     9001 gtattgatga ttatgtcctg caaaaataat atcaatacta tgttcgggat agatttggtt
     9061 cactttttcc ataaccgtag ccatttcatg atcaacaaca ccatctttac ttgttgcagg
     9121 aatatgagct aaaaccacaa tagcatgaac atgttgttct tgcagttctt tagcatattt
     9181 ggcaatggtt tcagctacat ctaaaaattg atagtgttca tagttttgct ttaaaacgag
     9241 atttggaatc tctgtagtca caacaccaat gaagccaatc ttaacgattt tgtcattaat
     9301 ggctatgtct tttatagcat aaggtttcca accatagggg atatcattag tttttttatc
     9361 aatgacatta gcaatgacga tggtttgatg cgaagcttcg tgctcatatt gtttggtgat
     9421 atcattaatt gttgattcag gatcaggcgc ttgacctgtc atgatacggt taaattcatc
     9481 tagtccttcg tcaaattcat gattaccaag agtgccatat tcaaatttca ttttgttaaa
     9541 gactttcaca gtaggctcat cttgtaaaag tgcagagtta gcaggactgg ctccgaccat
     9601 atctccagct tgaacacgta tacttgttcc gtcttgattt gcttgcttga aatctatctc
     9661 agcgtcatcc atataagcac ctaattgagc agccgtccca gcatttggta ttttaccact
     9721 tggtgtgtaa gctgttccgg tattatcaag agcgccgtga aaatcattga cgccaaggaa
     9781 ttgcacatca acttgatctg cttgaacatc tgtaactaat agagtaaaac tagtcaggat
     9841 actcaataca ctacttttta aaataaaata tttttcataa aatctcctaa taagttaacg
     9901 taatcgttat agatcaagtt tactatgttt ttgtttgtaa ttcaatggta tttttaaaaa
     9961 ataacgtaca aaaaatatat gaaagcgatt taaaaacaaa cgatacagat catttgcagt
    10021 tatatagtta gaaataaaga taaccgatca ttgcagagat ttaagcattt gttgagaaaa
    10081 tttgttataa taagcgtatg aaagaaagac tagaacatta ttctaccagc tctatatata
    10141 gcggatttga agtgtacttg ccgttggtac tacagacaat aacagatgtg attattgctg
    10201 agaatatcaa aagcaaaaaa gaaacggggt ttaaactata cgaacacttt acatcccgta
    10261 ttaaatcgga agcttcgatg attgaaaaat gtcaacgcaa acagcttcct ctaacaagca
    10321 aatctgcgtt aaaaatcatt aaagatagta tcggtattcg cattatttgt ggttttattg
    10381 atgatattta tcggatggta gacttgctca aaagcattcc tggtatgtca gttaacgctg
    10441 aaaaagatta tattttaaat gccaagccta atggctatag atcatatcat ctcattttgg
    10501 aattagaaac acattttcca gatattttag gggaaaaaaa aggatgttat tttatagaag
    10561 tgcagttgcg aaccattgct caagactctt gggctagctt ggaacatcaa atgaagtaca
    10621 aacatcaagt tgctaatgca gaaatgatta caagagagtt aaagcgttgt gcagacgagt
    10681 tggcatcttg tgatgttacc atgcaaacca ttcgtcaatt gattcaagaa acgacggagg
    10741 aagagtaacc atgaaaattt tgttagctga agacgaatgg cagatgtcta atgttttgac
    10801 aactgccatg actcatcaag gttatgacgt tgatgtggtt tttaacggtc aagaggcaat
    10861 tgataaagcc aaagacaatg catatgatat tatgatttta gatatcatga tgccgattaa
    10921 gtctggcatt gaggctttaa aggagattcg cgcttcagga aattgctcac atattattat
    10981 gctgacggct atggcagaaa ttaacgaccg tgttaccgga ctagatgcgg gagctgatga
    11041 ttatctgact aaacctttct cattaaaaga acttttagct agattaaggt cgatggaaag
    11101 acgagtagaa agttttactc ctcaggtatt acaatttgct ggtgtcacat taaatattaa
    11161 tgagcaagaa ttgagtgccg gtaatgctat acgattagct tctaaagaag gtaaattaat
    11221 ggccttttta atgttaaatc aaggaaagta cttggatact aaaacacttt accaacatgt
    11281 ttggtcagac caagaagatt atgatacttc tattgtttgg gtttatattt cttatcttcg
    11341 tcaaaaatta ttagctattc aagcaaatgt cattattgca ggtgataaag atactagcta
    11401 ttgtttatta gaaaaatagg aggtgacatg tttaatcgta tccgtattcg ttttatcatg
    11461 attgcttcta ttgccatttt tattatttta agttcaattg ttggtattat taacacggca
    11521 cgctgttacc aaagtcaaca agaaattaac cgtattttac atttaatttc ctcaaataaa
    11581 ggtaaattac ctgacactac ggaaagctct aaacgacttg gaacgaaact gtctgaagat
    11641 agcctaagcc agtttcggta ttatagtgtc atttttaatg ctaatggaca tctactttct
    11701 tctaatactg ctaatatttc agctttagat agagaagaag cccaatattt tgctagactt
    11761 tttgctaagt ctggggaaga aaaaggcagt taccgtcacc aagatagtgt ttattcgtac
    11821 ttgattactc agctgccaaa tgaagaaaaa ctggttgtaa ttttagatac taccttttat
    11881 tttcgtagtg taggagattt attagctgtt tcaatgatgt tggcctttgg aggatttatc
    11941 ttttttgttg ttttagtgag tcttttttcc ggtatggtca tcaaaccttt tgtccaaaat
    12001 tatgagaagc agcgtcgctt tattactaat gcaggccacg agttaaaaac accactagcc
    12061 attatctcag ccaataatga attggtcgaa ttaatgactg gagaatcaga atggaccaag
    12121 agtacaagtg atcaggtgaa gcgattgaca ggcttgatta atcaaatgat tactttggct
    12181 cgtttggagg aacagccaga tgtggtatta catatggtag acttttcagc tattgctcaa
    12241 gatgcagctg aagattttaa gagtctggtt ttgaaagatg gtaaacgttt tgatttgacg
    12301 attcagccga atattatgat taaagcggag gaaaagtcat tatttgaact tgtgacaatt
    12361 ttagttgata atgccaataa atattgtgat cctaaaggct tggtcaaggt atctttaacc
    12421 actattggaa gaagacgaaa acgagcgaaa ttagaagttt ctaataccta tttggaagga
    12481 aaatccattg attacagccg cttttttgaa cgcttttatc gcgaagacga atcccataat
    12541 agcaaagaaa aaggttatgg aattggttta tctatggcag aaagtatggt taagttattt
    12601 aaaggaacga taactgtaaa ttataaaaac gatgctattg tttttacagt ggtgatttga
    12661 cttaaacatt tttcagtacc tttagctagt aataatgtct aggtaaaggt aataaacgat
    12721 gcttaaccag cccatgaggc tggtttttaa cgtttaattt agtagaagag tgactaaaga
    12781 aggtagtttg aaataagaaa atttttgtta tgatcctaaa aagagtagat agtctttatt
    12841 gttaatttca gtgaagaaat gattttaaaa agatatatca tcgcattttc taatcattta
    12901 gtgtaaaata gtaaggtaaa agtttagaag aattagtaat gaaaagataa aaaatgaacg
    12961 aaaacattgg atatggtaag gcacacagta agatcatttt gataggtgag catgctgttg
    13021 tgtatggcta cccagctatt gctttgcctt taacagatat tgaggtggtt tgtcatattt
    13081 ttccagctga taaaccattg gtctttgatt tttatgatac tctatcaaca gccatttatg
    13141 ctgccttgga ttatttgcag cgactacaag aaccaattgc ttatgagatt gtttcacaag
    13201 tgccacaaaa gcgtggtatg ggatcttcgg cagccgtttc tattgcagct attagagccg
    13261 ttttttctta ttgtcaagaa cccctctcgg atgatttgtt ggaaatttta gtcaacaagg
    13321 cagaaattat tgcccacacc aatcctagtg gtttagatgc caagacatgc cttagtgacc
    13381 atgccattaa gtttatccga aacattggct ttgaaactat cgaaatcgcc ttaaatggtt
    13441 atcttatcat tgcagataca gggattcacg gtcatacacg tgaggccgtc aataaggtag
    13501 cacagtttga ggaaacgaat ttgccctatc tggctaaact aggagctttg acacaagccc
    13561 ttgaaagagc gattaaccaa aaaaataagg ttgctatcgg tcagctcatg acacaagcgc
    13621 actctgcttt aaaggccatt ggcgttagca tcagtaaggc tgaccaactt gtggaggctg
    13681 ccctaagagc aggtgcttta ggcgctaaga tgacaggcgg tggcttgggt ggctgtatga
    13741 ttgccctagc agataccaaa gacatggccg aaaaaatcag tcacagatta aaagaagaag
    13801 gagccgtaaa cacgtggatc caaatgttat aaccgtaaca tcctatgcta acattgctat
    13861 tatcaaatat tggggaaaag agaatcaagc taagatgatt ccttcgacct ctagcatttc
    13921 tttgactttg gaaaacatgt tcaccacaac cagcatttcc ttcttaccag atactgcaac
    13981 cagtgatcag ttttacatta acggtgtctt gcaaaatgac gaagaacata ccaaaatttc
    14041 tgctatcatt gaccaatttc gccaacctgg tcaggctttt gtaaagatgg aaactcaaaa
    14101 taatatgcca acagctgcag gtttatcatc aagttccagt ggcttatcag ccttggttaa
    14161 agcctgtgac caactattta acacccagct agatcagaaa gctttagctc aaaaggctaa
    14221 gttcgcctca ggatcatctt ctcgttcttt ttttggccca gtcgctgctt gggacaaaga
    14281 tagtggtgct atttacaagg ttgagactga cttgaaaatg gccatgatta tgctggtctt
    14341 aaatgctgcg aaaaagccaa tttctagccg agagggcatg aagttatgcc gcgatacctc
    14401 aactacattt gatgagtggg tagaacaatc ggcaatcgat taccaacata tgcttaccta
    14461 tctcaaaact aataattttg agaaagttgg tcagttaaca gaagctaatg ccttggccat
    14521 gcatgccacg acaaagacag ccaatcctcc tttttcttac ctaacaaaag agtcttacca
    14581 ggctatggag gctgtgaaag aactgcgtca agaaggtttt gcttgttatt ttaccatgga
    14641 cgcaggtcca aatgtgaagg tcctatgttt agaaaaagac ttggctcaac tggcagaacg
    14701 acttggcaag aactaccgta ttatcgtttc aaaaacaaag gatttaccag atgtctaatt
    14761 attgtgtgca aacaggtggg aaactatacc tcacaggcga atatgctatc ttaacaccag
    14821 gacaaaaagc cttaattcac tttattccac tgatgatgac agcagaaatt agcccagcag
    14881 cccatattca attagcttca gatatgtttg cccataaagc gggcatgaca cccgatgcct
    14941 cttatgcact gattcaagca acggttaaaa cctttgctga ctatctagga cagtcgattg
    15001 accaactgga gccattttcc ctaatcataa caggaaaaat ggagcgcgat ggcaaaaaat
    15061 ttggcattgg ttcaagtggt agcgtcaccc tcttaacctt aaaggcctta tcggcctatt
    15121 atcagatcac tttaacccca gagttactct ttaaactagc ggcttatacc ttgcttaagc
    15181 aaggagataa tgggtctatg ggggatattg cctgtatcgc ttaccagact ttagtcgcct
    15241 atacctcctt tgaccgagaa caggtcagta actggctgca gaccatgccc ttaaaaaaac
    15301 ttctcgtcaa agattggggt taccatatcc aagtcattca accagccctg ccttgtgact
    15361 ttttggttgg ctggactaaa atacctgcta tttcaaggca gatgattcaa caagtgacag
    15421 cgagcattac cccagctttc ttaagaacaa gttaccagct aacgcaatca gctatggtag
    15481 ctttgcaaga aggtcataag gaagaactca agaaaagttt agcaggagca agtcatctcc
    15541 taaaagagct tcatccagct atctaccatc ctaagctagt aaccttggta gctgcttgtc
    15601 agaagcaaga tgctgttgct aaatcttcag gttctggtgg tggagattgt ggcatcgcgc
    15661 ttgcctttaa tcaggatgct agagataccc ttatttccaa atggcaagaa gctgatatcg
    15721 cattacttta tcaagaaagg tggggagaga atgactaacc gtaaagatga tcacatcaaa
    15781 tatgctctca agtaccaatc gccttataat gcttttgatg acatagaact catacaccat
    15841 tccttaccta gctatgattt gtctgatatt gatctcagta ctcattttgc tgggcaagac
    15901 ttcgactttc ccttttacat caatgccatg acaggaggaa gtcaaaaagg caaagctgtc
    15961 aatgaaaaat tggccaaagt agcagcagca acagggattg tcatggtgac agggtcttat
    16021 agcgctgctt taaaaaatcc taacgacgat tcctatcgtt tacatgaggt ggcagataac
    16081 ttgaaactag ccacgaatat tggtctagat aaacctgtgg cgctaggaca acaaacggtt
    16141 caagaaatgc agcccctctt tttacaggtt catgtgaatg tgatgcaaga gttgctgatg
    16201 ccagagggtg agcgcgtctt tcatacctgg aaaaaacacc tcgctgaata cgctagtcaa
    16261 ataccagttc ctgtcattct caaagaagtt ggttttggca tggatgtcaa tagtatcaag
    16321 ctagcacatg acctaggcat tcaaaccttt gatatttcag gtagaggagg aacttcattt
    16381 gcttacattg aaaatcaaag agggggagac cgctcttact taaacgattg gggacaaacc
    16441 actgttcagt gcttactgaa tgcacaagga ctgatggacc aagtggaaat cttagcttcg
    16501 ggtggtgtca gacacccctt ggacatgatt aagtgttttg tcttaggagc acgtgcagtg
    16561 ggactctcac gcaccgtttt agaattggtc gaaaaatacc caaccgagcg tgtgattgct
    16621 atcgttaatg gctggaaaga agaattaaaa atcattatgt gtgctcttga ctgtaaaact
    16681 attaaagaat taaagggagt cgactactta ctatatggac gcttgcagca ggtcaattag
    16741 gcttcatcac ctctacaata gtgtcaccta ctacaaagat gatagagctt ttttagaaca
    16801 taatataaaa tatttataaa tacctcatca aactcagaat agagtagatg agtaaataga
    16861 gtatgttatg gagactattt ctaagacttg tatgtataga aacaaagatt aaacacccat
    16921 gtaaaccaat tgtttacatg ggtgtttgcc ttatattagt tgtttaaatc taagactgtc
    16981 ttagctggga taagtaaaaa tgtgcttttt ctagatttat tggtttatca gctagtaaag
    17041 cattaactaa aggagcaatt tcgtcttggg ttgcccccgc caaaagagct aatgatttcg
    17101 catgtagttt catgtgacca gcttggatgc cagatgaggt cagagctttt agtgcagcaa
    17161 agttttgagc taaccccaca gatgcaatca attgggctaa tgttttggca tcaggttgat
    17221 taagaagatc atgtgcgata gaaacagtag ggttaagccc gatagatccc cccttactag
    17281 caataggcat agggagggtc atttggccaa gcagaacttg tttatcttgg tcaaaatgcc
    17341 actgactaag tccttgatag ctaccatttc ttgaggcata agcatgggcc cctgcttcaa
    17401 tagcacgcca gtcatttcct gtggctatta ccactgcatc aataccatta aaaatacctt
    17461 tattatgagt agtagcccgg taaggatcta cttgagctag tcggctggct agctctattt
    17521 tttgagctaa ctgtagggat tttgttttat cgcgatctaa aaggcgcacg ggaatctcac
    17581 aactagtagt aacaagcgac tctgttgcgt aattagataa aatcgccatt agacaatgcc
    17641 ccttagacag tcttgttaaa tcaggaacaa gagcttccat catagtattg accatatttg
    17701 ctcccatagc ttcttgggta tcaacagtca gatagaaaat caaaaattct cctttttctt
    17761 ccaaatgaat ggttctagcg cctccacctc ttttaacaat ggaaggataa gctttatttg
    17821 ccaatgcaat tagctttttt gttttatgaa ggatggcggc tttagcgtta tctatttggt
    17881 cgatatcgta aagaacaatt tgaccaatca tttgtcggtt tagggtttga gctttaaaac
    17941 cacctgagcg tttgattagt tttgctgcga aagatgctgc agcaacaaca gaaggttctt
    18001 ccgtgacaaa aggcatctga taagttgaac cgttgacaag aaaatcagga gctatgctaa
    18061 agggcaaagc caatcgtcct aagacatttt cagtcatttg attagctgtt tggataggca
    18121 aaagaacgtc tgttttgagt tgatttaagt tttcagcatt aagtagttta aatttttcga
    18181 taagttggag gcgttcttcg aatgttttct ttgaaaaacc actccagtta agattagttt
    18241 ttgtcattgg tatgatagat cctttgatgc tccttgatgg ctgttagagc aaattttcca
    18301 gttaagtaaa tgtcaaaatt ggcattacca ttatcatcta attggacttg ttcgtagaaa
    18361 aggtcttcgt atttagaaac ggaaagacgt gttcgttgat ctagtaaagc ttgtcgatta
    18421 gtcattaaca ttttatcgta cccagcaact aactgaccgg aataaaattc acttacggca
    18481 ccggaaccat agctaaaaaa accaatttta tctccagatt gtaatacttt actattttca
    18541 agtaaagata acaatcctag ataaagtgag ccagtataaa tatttccaat ttgtttgcta
    18601 taagtaatag aagcttgaaa ggcttctatt agtttttccc tgtgttcagg aggtactgtg
    18661 ttatccataa tgttatttag accttttagg gctaacttgg gaaatggaat atggaaacaa
    18721 actgcagcaa aatcagataa ctgaaggttt tctcttttct gataagcttg ccacgtggtt
    18781 tctaagcaat tgagatattg cttggtagag taaataccat caacataagg tgtgaaacta
    18841 tagttaggcc tccaaaagtc cataatatcc ctagtttgag ccacattatc tttatttagg
    18901 gcaagaatac gagggttagc agttaccaaa agagcaatac taccagagcc ttgagttgat
    18961 tcgccaggag atcctacacc gtatctagca atatcactag caataacaag gacacgagaa
    19021 tctggcttag aagccacatg cagtttagca tagtctagag cagcagttgc gctatagcag
    19081 gcttgtttta cttcaaagga acgtgcaaaa ggctggatac caactaagtg atgtacatag
    19141 atagctgatg cctttgactg atcagtactc gattcagttg ccaaaataac catatcaatc
    19201 ttagctcgat cttcgtcagt taagatttga tctgctgcag aagcagctaa agtaataatg
    19261 tcttcagtga ttggtgccac actaaaagat tcaatgagta gcccttgact aaattttgct
    19321 ggatccactt ggcgtgcaag cgctaaatct tccaatttca agacatattg actggttgca
    19381 aaaccaatct tatcaattcc aattgtcata tttgtccttc ttttagttat ttttatagtc
    19441 ttacccattc tatcacattt tactgcaaaa ttagactgat aaagttattt gttttatcct
    19501 ttaatagtta aaatgttcat gaccacatga agtttttcga atgtttattt attctggtat
    19561 tttttggtaa aattagttag aatagtatga agtatgctta cagaaaggtt attagagatg
    19621 acaaaagctg accagatttt taaagctaat attcaaaaaa ttataaatga aggatcattg
    19681 agtgagcaag cacgtcctaa atataaagat ggtcgaacag ctcattctaa gtatattact
    19741 ggggcgtttg ctgaatatga tttagctaaa ggagagtttc ccatcacaac tttacgacct
    19801 attccaatta aatctgctat aaaggaatta ttttggatat atcaagatca gtctaacagt
    19861 ttagatgtgc tagaagctaa atataatgtt cattattgga atgaatggga agttgaccag
    19921 acacgtacta ttgggcaacg ttatggtgct gtagtcaaaa aacatgatat catctcaaaa
    19981 atactaaagc aattagcaga aaatccttgg aatcgtcgta atgtcatttc tctctgggac
    20041 tatgaagcat ttgaggagac aaaagggttg ttgccatgtg cctttcaaat catgtttgat
    20101 gttagacgtg taggggaaga tctttattta gatgctagtt tgacgcaacg ttctaatgac
    20161 atattagttg ctcatcacat caatgccatg caatacgttg ccttgcagat gatgattgct
    20221 aaacattttg gatggaaaat aggtaagttc ttttattttg ttaacaattt acatatttat
    20281 gacaaccaat ttgatcaggc tcaagaatta ctaaaacgac agccagttgc cagtcagcct
    20341 aagcttgttt taaatgttcc agatgggact aatttcttcg atattaaacc agatgatttt
    20401 gaattacaaa attatgatcc agtgaagcct cagttgcact ttgaccttgc tatttaaact
    20461 ttatttagat tttttgtgag cattttgttc ataaatttgg taaaataaat agagtttaaa
    20521 atgaaggaaa taattaatga caaaggaaat tattgctatt tgggcagagg atgaagcagg
    20581 gcttattggt gttgcgggta agttaccatg gtatttacca aaagagttag aacattttaa
    20641 aaagacaacg ctacatcaag caatcttaat gggccgtgtg acttttgaag gaatgaattg
    20701 caaaagactt cctcaacgtc aaacccttgt catgacaaga aatagagatt atcaagtaga
    20761 tgaggtgttg acaatgacta gtattgaaaa agtcttggag tggtaccatg cgcaggataa
    20821 aacactttat atcattggtg ggaataaggt tttagaagcg tttaatggtt atttcgatcg
    20881 tatcataaaa acagttatcc atcatcgttt taaaggagat acctaccgac cacatctaga
    20941 ttttagtcat ttcacgcaag aaagccaaac gttctatgct cgagacgcta aaaatcctta
    21001 tgattttacc gttactgctt taaaacacaa atagtctgag gagatgataa gcgatgcaac
    21061 gtagtatttt tggagtattt acggcttttt tgtgcgtgat ttgtgttctt tgtgccatcc
    21121 cagcttttaa aaagaatcgt tatggcttag caagtctgtt cttattaaat gcgtttacta
    21181 atctggttaa tagtattcac gccttctatg gtacattgtt ttgagatgcg acttgcaaag
    21241 acagcactgg tgaagattta gctatcaagc aagaatcacc aaaaaccaat acaacacatt
    21301 gactaatatt aaaattcagt aaaagataag agaaagtaag agaattataa gaaatggcag
    21361 gaagtagaac taacgatatt aaagtatact gttcattttg tggtaaaagc caggatgacg
    21421 ttaaaaaaat tatcgcagga aataatgttt tcatctgcaa tgaatgcgta gctttatcac
    21481 aagaaattat aaaagaagaa ttggctgaag aagtccttgc cgatttgaca gaagttccaa
    21541 aaccaaaaga gctccttgat gttttaaatc aatatgtggt tggtcaagat cgtgctaaac
    21601 gtgctttatc agttgctgtg tacaatcatt ataagcgtgt ctcgtttaca gaaagtcgtg
    21661 atgacgatga tgtggattta caaaagtcca acattttgat gattggacca acaggttcag
    21721 gaaaaacctt cttagcacaa actctggcta aaagcctcaa tgtaccattt gctattgcag
    21781 atgcaacttc tttgactgaa gcagggtatg ttggagaaga tgtggaaaat attttactca
    21841 aactgattca ggctgctgac tataatgtcg aacgagcaga gcgtggtatt atttatgttg
    21901 atgaaataga taagattgct aaaaaaggtg agaacgtatc tatcacacgt gatgtatctg
    21961 gtgaaggtgt acagcaagcc cttcttaaaa ttattgaagg tacggtagca agtgttcccc
    22021 cacaaggtgg gcggaagcac cctaatcaag aaatgatcca aattgataca aaaaatatct
    22081 tgtttattgt tggcggggct tttgatggca tcgaggagat tgttaaacaa cgtttaggtg
    22141 aaaaagttat tggttttggt caaaacagcc gtaaaattga tgacaatgct tcttatatgc
    22201 aagaaattat ttcagaagat attcaaaagt ttgggcttat tccagaattt attggccgct
    22261 taccagttgt ggcagccctt gaacaactaa acacatcaga tttgattcaa attttgacag
    22321 aaccaagaaa tgccctggtc aagcaatatc aggcccttct ttcttacgat ggcgtcgaat
    22381 tggcatttga taaggaagcc ttagaagcca ttgccaataa agccattgaa cgtaaaacag
    22441 gagcacgtgg tcttcgttct attattgaag aaacgatgtt agacattatg tttgaaattc
    22501 caagccaaga agatgtcaca aaagtgcgta tcaccaaggc tgctgtcgaa ggcaagtcaa
    22561 aacccgtttt agagacagct taaggagaaa taatggctga agaacaagtc ttaaataccc
    22621 ataacgcctc aattttattg agcgctgcca ataaatctca ttacccccaa gatgatttgc
    22681 cagaaattgc ccttgctgga cgttcaaatg ttggtaaatc aagttttatt aataccatat
    22741 tggggcgcaa aaatttggca agaacctcaa gcaagccagg aaaaacccaa ctattaaatt
    22801 ttttcaatat tgataacaag cttagatttg tggatgtccc tggttatggc tatgccaagg
    22861 tttctaaaag tgaacgggcc aaatggggaa agatgatcga agaatactta accagcagag
    22921 acaatctgcg tgcagtcgtg agtttggttg atttacgtca tgccccttca aaagaagata
    22981 ttcagatgta tgactttttg aagtactatg acattcctgt tattgttgtg gcaaccaaag
    23041 cagataagat tcctcgtggc aaatggaaca aacatgagtc tgtggtcaag aaagctttga
    23101 attttgacaa atctgatact tttatagtat tttcttcggt agaacgtatt ggtatcgatg
    23161 attcttggga tgctatttta gagcaggtct agcgataggt gttgatttat ctatgctaaa
    23221 acattctcag tagagggtgt ttttcttatc gaaaacataa aaaatcatag ttaggtttac
    23281 cgattttact tgacgcctta atgatgacat gctagtattt tatattaagg agatgagtca
    23341 tgacacaagt agcccaaggg cgctctaaag gaaagtcatt gttatgccat caatgcaatg
    23401 ccctttttgt atttattatt tttcttatct tgcttgctgt actttttggt gttcgatatc
    23461 gtaatagctc tattgaaggt atctggcgaa caacaagcat tgatcagaag ttaggcgatg
    23521 attttgctaa acgtcttact ggtttgcatc agagccctct tattgatgat agtttattaa
    23581 cgtcatctca gatgatacta acagttaaaa ataacaacgt tgacttgagt tttagtgttc
    23641 aagttgaacg agacattttt gtcaaacgtt tagctgctta tcaccaaaat gaattattaa
    23701 agacattaaa ggaaaatcat ttagttgttg gtgacttgag tagtaaagaa cgccaaatta
    23761 ttgagaatag tatgccagct agccatgaat tagaaatgat tttagatcaa gcttttgaga
    23821 aattagcttc tcagatcgga ggcaaatata atcaaaaaac aggacattta tctgctgttg
    23881 ttctcaaagg aaaagttaat cgtattttgc acaccattga tatcaaagaa gaagtagcag
    23941 cgggacatac ttctttttca aaaggattgc tcacacctaa tggttatttt gattacacca
    24001 gatttggaaa gaaacttgag ttattaggcg atgaaaaaat tatttttaaa aaagtgctaa
    24061 aaaaaagtcc gtcaagtgta taacgtagtc acaagacgga ttttttcatg ttttgaaaat
    24121 tattcaattg aagaagttta ttactgatcg ttttgcctaa tcactagttg tccttctttt
    24181 aggattgcct gaagtttttt gacttctgga tggtcaagat aataatcagt tatacggtca
    24241 cgaatttcct gttcgataat acgtcgtaat ggacgagctc ccatagcgcg attgtaccct
    24301 aaatctatca aatgagcttt agcgtcatca gcaatcgtta aactaatacc tttttttgcg
    24361 gtggtttgat ttacttcagc tagcattaaa tcaacaattt cttctaaatt ttctttttgc
    24421 agatgattaa atttaatgat actattaaaa cggttcaaaa actctggtct gaaataaggt
    24481 gcaatgcgat ccataatgtt aaacccagaa gtttccgtat cttgttggcc aaaaccggca
    24541 tttgatgtag caataataac ggtattttta aagttaatag tatttccttg tccatctgtc
    24601 aatcgtccat catctaacac ttgtagaaga agtgtaatga tttgaggatc agctttttca
    24661 atttcatcta gtaagacaat agcataaggg ttacgacgaa cacgctcagt tagggtatta
    24721 ttattatcat cgtagccaac ataaccagcc gttgtcccaa tcaattttga cacagcagtg
    24781 cgatcgttat attcggacat atcaagtcga ataatagcat ctttggaacc aaataaatca
    24841 agtgctaatt gtttagctaa ctctgtttta ccaacaccag ttggacccac aaaaaggaaa
    24901 gaacctattg gacggttacc atcatcaaaa cctgctcgat ttcgtcgaat agcgcgtgct
    24961 actgctgcaa cagcctcatc ttgtccgatg acatggcttt ttaagcggct gctaattcct
    25021 ttgagccttt ctaaatcatt agtccccatg ttagagacag gaataccagt taagcgctct
    25081 acagactctg cgatatcatt gactgtagca gtgacatttt gggtttggtt atgttgctca
    25141 atttgctttt gtaatgtttc aatccgtgtt tttgctgcta aagctttttc aaagtcttct
    25201 ttggcgacag ctttttcttg cctctctttt tgtttagcta tttcagtttc gagtgttttt
    25261 aagtcagtga ccgggtgttg cgcagctaaa tgagcagctg tcatatccag taagtcaatt
    25321 gctttatctg gcaggctacg ctgtgggatg tattgaatag aataatcaac agcagctttt
    25381 agaacattat caggaagggt aatatggtgg tgttgttcat aaagattacg aatacccatt
    25441 aaaatgtgaa aagtatcttc agctgatggt gcattcactt taacttcatt aaagcgacga
    25501 gcgagagcag cattttttaa aatagtattg cggtattcgt cttgagtagt agcaccaatc
    25561 agtgttaatt ctcctcgtga caaggctggt ttaagaatat ctgcaagtcc ctttgagcct
    25621 gaatcactgc ttgtggcacc agcaccaact atttgatgaa tttcatcaaa aaataagatg
    25681 atattcccag cttcttttac ttcttgaatc aagttttgaa tggtctcttc aaaggaacca
    25741 cgatactgtg taccagcttc aagactagaa atatcaattg atacgatttc cttgttttta
    25801 atagcagctg ggacatctcc attaacaatg gcttgagcta aaccttcaat gactgcagtt
    25861 ttaccgacac cagcatctcc gacaaggaca ggattatttt tagttcgtcg tgccaagatt
    25921 tcagcggtat cttgaatttc tttgttacga ccgatgacgg gatcaagatg cccttgacga
    25981 gcttcttgtg ttaagttagt tccgagttga gtcaatacac tatcagcttt aggtgttaac
    26041 atttgagaat ttgttgcttt ggttgtcgct acagggagtt gtcctgtttg acgatagtgt
    26101 tggaattctt cgggagttat ttcgcgaccg ttaacgagat agcggggatt ttcgctacga
    26161 taaccaccca tgtttgccat taattggttg aaaatatcat ccatatttac aaaaggatct
    26221 ttaccagaaa aatgtgtcat atcagttacc tcgcaataaa aaatagacta taagatgttt
    26281 gtaagcagtc gcagaatcgt tgttaggatt tcacatgata ggaaaccctt tgctaataaa
    26341 atgattcaga cattattttt actcatctta tagtattatt ataatcaaaa ggtcagtaaa
    26401 ggtcaaacaa aaacgcttga ttttcaaaaa gctaaataaa cacgaaaagt aagtgcttat
    26461 atgatgactt tagaataaat cataagtttt aaaaagatca tcctattcta tagcacttag
    26521 gctgtcaatg agagaaaaac aaatgttttc attaacaagt tggcgctttc atggtataat
    26581 aaagtgctaa gacgcaattc tattataagg gggaatcatg gaagcactca aaaaaattgc
    26641 cggtgttacc gctgcgcaat atgtgactga tggcatgacc attgggcttg gaactgggtc
    26701 aacggcttac tattttgttg aggaaattgg ccgtcgcgta aagcaagaag gactgcaagt
    26761 ggttggtgtg actacgtcaa gtgtgactag caagcaagca gaaggcttag gcattccttt
    26821 aaaatcgata gatgatattg atagcattga cctcaccgta gatggtgctg atgaagtgga
    26881 taaggatttc aatggaatca agggtggcgg cgcagcctta ctaatggaaa aaattgttgc
    26941 aacaccaaca aaagaataca tctgggttgt tgatgcttct aaaatggtag agcatctggg
    27001 tgcctttaag ttaccagtcg aagtcgttca atatggtgct gatcgtttgt tccgtgtctt
    27061 tgaaaaagct ggttacaaac cgtcttttcg tatgaaaggt gatagtcgtt tggtgacaga
    27121 catgcaaaac tatattattg atcttgattt gggttgtatt aaagatcctg ttgcttttgg
    27181 tcacctgcta gatggaacag ttggtgttgt ggaacacggt ctctttaatg gtatggttga
    27241 taaggtgatt gttgctagta aagacggcgt tactgtttta gaagcgccta aagcaggcta
    27301 gtcttagcat ataacagtgt taatatattt tataggtatt ggggagtcaa ccgtaacctc
    27361 ccctagattg gagacttatg tcaaaattta atcgtattca cttggttgtt ttagactctg
    27421 tcggtattgg tgcagcgcca gatgctgaca aattctttaa tgctggtgta gctgatacag
    27481 attctgacac cctcggtcat atttcagaaa cagcaggctt atcggttcca aatatggcaa
    27541 aaattggact tggaaacatt tctcgtccga taccactaaa aactattcca acagaagaca
    27601 atcctactgg ttacgtgacc aaattggaag aagtatctct tggaaaagat accatgacag
    27661 gccattggga aattatgggc ttgaacatta cggaaccttt tgacactttc tggaatggtt
    27721 tcccagaaga gattttaact aagattgaag aattctcagg tcgcaaaatt attcgtgaag
    27781 ctaataaacc ctattcagga actgcggtta ttgatgattt tggtccgcgt caaatggaaa
    27841 caggtgagtt gattgtttac acctcagcag acccagtgct tcaaattgca gcccatgaag
    27901 acattattcc tgtggaagag ctttacaaga tttgtgaata cgctcgctcc atcacgcttg
    27961 aacgccctgc ccttttaggc cgtattattg cgcgtcctta tgtaggcgaa ccaggaaact
    28021 ttacacgtac ggctaaccgt catgactatg cagtgtctcc tttccaagat accgttttga
    28081 acaaactggc tgacgcaggt gtcccaactt atgctgttgg taagattaat gacatcttta
    28141 atggttcagg tattacaaac gacatgggac acaataagtc gaacagccat ggtattgaca
    28201 cgcttattaa gactcttcaa ttacctgagt ttactaaggg attctccttt actaacctcg
    28261 ttgattttga tgccaacttt ggtcatcgtc gtgacccaga gggttatcgc gactgcttgc
    28321 atgaatttga caatcgccta cctgaaatca tcgcaaatat gaaagaagac gatttgcttc
    28381 tcatcactgc tgaccatggt aatgacccaa cctatgcagg caccgaccac actcgtgaat
    28441 acattccatt gcttgcctac tctgcatcct ttactggaaa tggtcttatt ccacaagggc
    28501 attttgcaga tatttcagcg actgttgcag aaaattttgg agttgataca gccatgattg
    28561 gggagtcatt ccttggtcac ttaaaataag aaagttagta attgataatg gaagaaatca
    28621 cgatttatca taatccaaac tgtggcactt cacgtaatgt tcttgccatg attcgccatg
    28681 caggtattga gcctactatt attgagtatt tgcagacgcc acctaatcgg gagactttaa
    28741 ttgagctctt acaatcgatg ggaatctctg cgcgagaact cttgcgaacc aatgttcctg
    28801 aatttgaggc tcatggatta gcaaatcaag cagtagctga gaaagacgtt attaatgcca
    28861 tgttgacgga tccaattttg atcaatcgtc ctattgttgt gactcgcaaa ggagtaaaac
    28921 tttgccgtcc ttctgagacc ttactggata ttcttcctgt tcccctgcct agtccttata
    28981 ttaaagagga tggcgagatt gtgaacccta ttgaggtaaa aggagaaaaa gatgtcattg
    29041 atgactaaaa ttaacgaaac aaaagacttt ttagttgcta aaggaattga agctccagaa
    29101 tttggattaa ttctgggttc aggccttggt gaacttgctg aagaagtaga aaatgctatt
    29161 gttattgatt atgcagatat tccaaactgg ggcaaatcaa cagttgttgg ccatgctgga
    29221 aaattagtct acggtgattt agctggtcgt aaagtacttg ccctacaagg tcgtttccat
    29281 ttttacgaag gaaatccgct tgaagtggtg actttccctg ttcgtgtcat gaaagctctt
    29341 ggatgtgaag gcgttcttgt cacaaatgca gctggtggta tcggctacgg cccaggtacc
    29401 ttgatggcaa tcacagacca tatcaatatg accggaaata acccactaat cggtgaaaac
    29461 ttggacgagt ttggtccacg cttccctgat atgtctgatg cctatactaa ggtttatcgc
    29521 aataaggcac atgaagtggc tgaaaaaatg aacatcaagc tagaagatgg tgtttatatg
    29581 ggcttaactg gtccaactta tgaaacacca gcagaaatcc gtgctttcaa agtattagga
    29641 gcagatgctg ttggcatgtc aactgtacca gaagttattg tggctgctca ttctggactt
    29701 aaagtacttg gtatttcagc tattacaaac tttgcagctg gttttcaatc agaattgaac
    29761 catgaagaag ttgtggaagt gacccaacat atcaaagaag atttcaaagg tcttgttaaa
    29821 gctattttat cggagttgta ggacgaacaa aatcaactgg agcattatta caggaatgtt
    29881 attttatgtc gtcagtttgg cacatctgtt cgcaataaaa aaatcaaaaa ataatcacgg
    29941 ggtgtgagtt ccatgaatgt tgaactcaga ttctagcttt tctaactaac ataaccaacg
    30001 aagggaaaga gacgtattcg gtttaaattg agtatggact cgaacatttc ttcgtattaa
    30061 tttttaaata ataaaggaaa gagagttagt cctttcttat ttgaactcga tttttagctc
    30121 tcttctattc aatatcaatt atgaaaggaa tggggttgta ttcaattgaa tacgggcgga
    30181 aagctcggaa actagataaa ctaacttttg agctcacaca tggcgttagt tccctaaatt
    30241 tcagtcgctt tctgtccgcc ctctgacctt ctacaaaata aaaggaaagg tagggctaac
    30301 tgtattcatt gaattgaata cgggcggaga actgtttttc ttccttataa aaaataaaaa
    30361 aataagaaag gtgagggctg agttcattaa tttgaattcg ggctaaggac ttggtcaaaa
    30421 agataagttg tctagaaaat caggattttc tgccaacttc ctattttgcc atcgttcttt
    30481 taacgccctc agtatcataa tttatgtcta tccatatttc tgccaaaaaa ggcgatattg
    30541 ctgataaaat tcttctacct ggagaccctt tgcgcgcgaa atttatcgct gaaaatttcc
    30601 tagaagatgc agtgtgtttt aacgaagtgc gtaacatgtt tggctacaca ggaacttaca
    30661 aagggcaccg cgtttctgtc atgggaactg gtatgggaat gccttcgatc tctatctatg
    30721 ctcgtgaatt aatcgttgat tacggtgtca aaacattgat ccgtgttggt actgcgggtg
    30781 cgattgaccc agaagttcat gtgcgtgaat tggtgcttgc ccaagcagca gcaaccaact
    30841 caaatattat ccgtaatgac ttcccagaat ttgatttccc acaaattgct gattttggtt
    30901 tacttgacaa ggcttaccat atcgccagag aaatgggagt aacaactcac gttgggaatg
    30961 tgctttcttc tgatgtcttt tacactaaca tgcctgagcg taatatggtt cttggtaaat
    31021 tgggtgttaa agccatcgaa atggaagcag cagctcttta ctatttagct gctcagcacc
    31081 atgtcaaagc ccttggaatc atgacgatct cagataactt gaatgatcca accgaagata
    31141 ctacagctga agagcgccaa accactttca ctgatatgat gaaaattggt ttggaaactt
    31201 taattgccaa tgactaataa tcaaacgcta gacatccttt tggatgtcta tgcttataat
    31261 cacgtcttta gaattgctaa agccttgcca aatatcccta aaactgttct ctatttacta
    31321 gagatgttaa aagagcgcag agaattgaac cttgcctttc tggtggaaca tgcagcagag
    31381 aatcggacca ttgaagacca gtaccactgt tcattatggc ttaaccaatc gcttgaagat
    31441 gagcagattg ccaattacat tttggattta gaagttaaag taaaaaacgg tgctattatt
    31501 gatttcgtca ggtcagtgtc gcctattctt taccgacttt ttctcagact aatcacgtca
    31561 gaaattccaa acttcaaggc ttatattttt gatacaaaga atgaccaata tgatacctgg
    31621 cattttcagg ccatgttgga atctgatcac gaggttttta aggcttacct gtctcaaaag
    31681 cagtctcgca atgtgacgac caaaagctta gcagacatgt tgacgttgac ctccttacct
    31741 caggaaatca aggacttggt ttttttgtta cgacattttg aaaaggctgt tcgtaatcct
    31801 ctggctcatt tgattaagcc ttttgatgaa gaggaattgc atcgcaccac tcatttttct
    31861 tctcaggctt ttttggaaaa cattatcacc ttggcaactt tttctggtgt aatctaccga
    31921 cgtgagcctt tttactttga tgacatgaat gccattatta aaaaggagtt gagcctttgg
    31981 agacaatcta ttgtctgata tttatcaaaa aacacgataa cttgaccgat acaggtctta
    32041 ctaccgtgtt tttttagtat gacgattgaa aaagaaatta atcaaaggtt acttcttcga
    32101 gaaggtattc gataaaacgt tcccccattt tggacaagtt ggctttttca tgcttgataa
    32161 aaacaatgtc aatttcgtca gggacatcta gcgggatagc cacaatctgg tcaccattta
    32221 gattgctatt tagaatacca ctggcaacgg tgtagccatc taaaccaatc attaagttaa
    32281 agagggtggc acggtcactg accacaattg atttgttgtg gggcatctgg gacatcatct
    32341 cttctgaaaa ataaaaggag ttgtgaatcc cttggtcata gctcaggtaa ggaaaatctc
    32401 tcaagtcgtc catgcttaat aggcttttag ttgctagagg atttgatttg ctgacaaaaa
    32461 tatgaggctg tgccttaaat aatggagagg cagtcaaatg attgtcatca aataatttgg
    32521 tcaagacatc tcggttatag tcgttgataa agagaacacc aatttcagat cgaaagtttt
    32581 tgacatcatc aatgatttcc caagttcttg tctcgcgcaa aaagagttcg taccgagtca
    32641 tgtcggtccg cttgaggagt gagacaaatg cattgactac gaaggcataa tgttgagatg
    32701 aaacgctaaa gagctctcgg ccagtattgt ggtttttata gcggtcttct aacagtgatg
    32761 tttgctctat aatttggcga gcataagata aaaattccac cccatctttt gtcaaggtga
    32821 tccctttagg atttcggttg aaaatggtaa tgcccatctc catttccaaa tccttgaccg
    32881 cattggatag acttggttgt gtgataaata attgcttagc agcttcattc atagagccgc
    32941 actcaacaat tttgataata taatgcagtt gttgaattct cataagtaca gtctagctca
    33001 aaaaaaataa agacgcaagc acaaacgtca tcatgggttt agaactttga aaaagcgctg
    33061 gagtcttttc tcaatatggc ctaggataaa tatgattcaa ttttgagagt tgaatctatc
    33121 aatttcattg cccttttatt tttcttgtgt tatattaata gtattaacaa ataggtattt
    33181 ttctaatcaa agggtggtgg tcgtgtgaat gttactgaac aaaatagtca tcaaatctta
    33241 atccaaaaat tattggtcag tatccactat ttgactcttt ttcgagatga actgaagctt
    33301 gtagaacgaa ctccttctat acttggaggg gaatttccag ctcatttagt acagtctgag
    33361 ttgggagata ttgttgcggc cattgatacc ttggatatgc agcaacgctt gattgagtct
    33421 accttttggt atgaagaatc agcttttaag ttgatgaaca aaactttgga tattgtcgat
    33481 aattggatta aaggagtgga tcatctgata gatttatgcc agtccaaaga agtctttcaa
    33541 attattattg gagataaacg cattcgagtt tttggggtct taagtgatgt tttttcatct
    33601 ttaaaagtga gtgctttgtc acttaaggaa gctcctattc cggatttgct ctatgaacat
    33661 atccagaggg ttaatcttga agaagaagct tttataaaat attaccaagg ccctaaggta
    33721 cccacaggtg agtttgaata aatgattggg taaaaatgat aaaatgagtt gacgtaagta
    33781 tacaaaaaaa gatatagtag gaaaaatgtg ttcaaataac aaaaagtttt gacaccttgt
    33841 tttaaaaaag ctataatagt ttaaatttag acacctttaa gtgagtccag agaggcaaac
    33901 aaggtataca agataaaaaa agggaattcc cttttagttt gctgtagcct cgcttctttg
    33961 gtagcgaggc tttttggtgc ttaatgagat attgacacat tatagaaagg ataagttatg
    34021 aaagaagaac gcccaattat tgctttagac ttttcatcat ttgaggagac taaagcattt
    34081 ttagacttat ttccagcaga agaaaagcta tacgtgaaaa ttggtatgga attatattat
    34141 gcgcaaggac cagatattgt tcggtatatc aaatcgttag ggcataatgt atttttggat
    34201 ttaaaattac atgatattcc aaatactgtt cgtgctgcta tggcagttct taaagaatta
    34261 gatattgata tggcaactgt tcatgcagct ggtggtgtag agatgctaaa agcagctcga
    34321 gaaggactag gtcaaggccc taccttaatt gcggtaacgc agctaacttc aaccagtgaa
    34381 gaccaaatgc gtggtgatca aaatattcaa acgagtcttt tagagtctgt tttgcattac
    34441 agcaaggggg cagctaaagc tcagctagat ggggtggttt gttcggcaca agaagtagaa
    34501 gctatcaagg cggtgacacc tacaggattt acttgcttaa ctcctggcat tcgtcctaaa
    34561 ggcagtaata ttggcgatca aaaacgagtg atgactccaa accaagcaag acgcattgga
    34621 agtgattata ttgtggtagg gcgaccaatt acccaggcaa aagacccagt ggctgcttac
    34681 caagccataa aagctgagtg ggcaggctaa cagataagat taggaaacca acacttgtct
    34741 gttaaagaag aaaaaggaga ataagaaatg acactagcaa gccaaattgc aactcaatta
    34801 cttgatatta aagctgttta tttaaagcct gaagatcctt ttacgtgggc atctggcatt
    34861 aaatcaccta tttacactga taatcgtgtc accctttctt atcctaagac tcgtgattta
    34921 attgagaatg ggtttgtgga aactatcagg gctcatttcc cagaagttga ggtcatcgct
    34981 ggtacagcta cagcaggtat tcctcacggt gccattatag cagataaaat gactcttcct
    35041 tttgcttata ttcgcagtaa gccaaaagat catggagcag gcaaccagat tgaggggcgt
    35101 gtgcttaaag gccaaaaaat ggttatcatt gaagatttga tttcaacagg tggttcggta
    35161 ctagatgcag ccgcagcagc cagtcgtgag ggagctgacg ttctgggagt tgttgcgatt
    35221 ttcacttatg agttaccaaa agctagtcag aattttaaag aagctggtat caagttgatt
    35281 acgctttcta attatactga gctaattgca gttgcaaagt tgcaaggcta tattactaat
    35341 gatggtttac atttacttaa aaaatttaaa gaagaccagg taaactggca acaataagga
    35401 actatcagcc aggtttattt ttaatgaaaa aatctcttta accccaattc aaaatgttat
    35461 gttttgattg ttttgtctac attccttaca catcacattc taatttctaa ccttttaatg
    35521 gtggttttct tttatttgtg ttttaataaa aaagaatgtt ttaggattca tatcttagaa
    35581 aggaagagta gctatgactt atcaagatgc gacggctatg gctattgctg ttcagactgg
    35641 tcagaccaca ccactagaat tagtaaccca ggctatttat aaggctaaaa agttgaaccc
    35701 taccttaaat gctattacct cagaacgctt tgaagcagcc ctagaagaag ccaaacaaag
    35761 ggatttttca ggtctgcctt ttgcaggagt tcccattttt ttgaaagatt tgggacaaga
    35821 attaaaaggt cactcatcaa cctcaggttc cagattgttt aaagagtatc aagcgactaa
    35881 aacggattta tttgtgaaaa gattagaagc tttaggcttt attattttag ggcgctccaa
    35941 cacgcctgaa tttggcttta aaaatattag cgatagcagt ttgcacggac cagtgaattt
    36001 accaaaggat aatacacgaa atgctggtgg ctcgtcaggt ggtgcggcag ctctagtgtc
    36061 atcaggaatt agtgcactag caccagctag tgatggtggt ggttctattc gaattccagc
    36121 ctcgtttaat ggcttaattg ggctcaaacc tagccgtggg cgcatgcctg tcggacctgg
    36181 ttcttatcga agctggcaag gagcctcagt tcattttgcc ttgaccaaat ccgttagaga
    36241 tactagaaat ctactctact atttacagat ggaacaaatg gaaagcccct tccccctagc
    36301 caccttaaca aaagatagta tttatcaatc gctacaacgt cccttgacaa ttgcttttta
    36361 tcaacggtta agtgacggta gcccagtatc tttagatact gcaaaagctt taaaacaagc
    36421 agtaacttgg ctaagagaac aagggcatca gctagttgaa ttggaagagt ttcctgtaaa
    36481 tatgacagaa gtgattcgtc attattatat tatgaatagt gtggaaacgg ctgctatgtt
    36541 tgctgatatt gaagacactt taggacgtcc gatgaccaaa gacgatatgg aaaccatgac
    36601 ctgggctatt taccaatcag gtaaagacat cccagcttgg cgttactcac aggtccttca
    36661 aaaatgggat acgtacagtg caaccatggc tagttttcat gagacttatg acctgttgtt
    36721 gacgttcaca accaacacac cagctcctaa gcacggagag cttgtcccag attcgaaact
    36781 catggctaac ttggctcaag ctgaaatttt cagcagtgaa gaacagttca atttggtcga
    36841 aaccatgttt ggtaagagtc tggctattaa tccttacaca gctctgccta atctaactgg
    36901 ccaaccagct attagtttac ctacttacga aactaaggaa ggtctcccaa tgggcattca
    36961 actaattgca gccaaaggta gagaggacct attattagga attgcagagc agtttgaggc
    37021 agcaggatta ttgaagattc ctcaataata atcttataaa acagtttaac tattatagat
    37081 taacttttta aagagattga gcgctcactg ataacacaac ttaatcaaaa tgttatacta
    37141 ttcttatctt aataaaggag ttactatgaa gaaatcagtt actttactgt ctatcggact
    37201 tgccagcctt ttattggcag catgtgcgcc acataaatct caaaaatcaa gttgggagac
    37261 tatcaaagaa aaaggggtgt taaaagtagc taccccagga acctatcagc caacttcttt
    37321 ttacaacgat aataatgagt tagtaggtta cgaagtagat atggtcaagg aaatcggtaa
    37381 acgacttaac attaaagtca agtttgttga aacaggattt gaccaagcct ttacctcagt
    37441 tgatagtggt cgagtggata tttctttgaa caactttgac attaccccaa aacgtcagaa
    37501 aaaatacaat atctctacgc cttataaata cggggtagga ggcatgattg tccgtgctga
    37561 tggcagctca aacatggtta aaaaagatct tagcgactgg aaaggaaaaa aagcagctgg
    37621 tgcttctgga acagaataca tgaaagtagc gcaaaaacag ggagctgaac tggtgaccta
    37681 cgataatgtt acaggagatg tttatctaaa cgatgtggct aacggtcgaa cagatttcat
    37741 tccaaatgat tacccagctc aaaaattatt tgtggattac atgttatctc aaaatccaaa
    37801 tctaaatgtc aaaatgagcg atgttcagta caacccaacc gaacaaggaa ttgttatgaa
    37861 caaaaaagac gatagcctca agaaaaaaat agatgctgtt attaaagaca tgataaaaga
    37921 tggtagcttg aagaaaatct ctgaaaccta ctatgctggt caagatttga caaaaccttt
    37981 tggcaaagac aaaaaaattc ccgtcattga tacgaaagac gttaactaat acttgatgtt
    38041 aaaggagtcc taaccacatg attaatatcc cattaatgaa agatagttta ggatttgtgt
    38101 tatcgggatt accttatacc cttggtattt cgttgctcag tttttttacg ggtctgtttt
    38161 taggtttagg cctagccctt ctgggaaggt cacgtcagcc gttgattcat tatcttgtta
    38221 gagcgtacat ctctattatg cgaggtgtgc cgatgatcgt ggtgctcttt gttctttatt
    38281 tcgggttgcc ttattatggt ttagaattgc cagctttact ttgcgcttat cttggttttt
    38341 ctatggttag cgctgcctat atttctgaag tttttcgctc ttctatagaa gctattgaca
    38401 agggacagtg ggaagcagct aaggctttag ggttgccata tgctcttatg gttaagaaaa
    38461 ttattcttcc tcaagccttt cgaattgcag ttcctcctct aggcaatgtc attattgata
    38521 tggttaaaag ttcgtcgcta gctgccatga ttaccgtacc agatattttt caaaatgcca
    38581 aaattatcgg tggtagagag tgggattaca tgtccatgta tattttagtg gcctttattt
    38641 attggcttat tgcttttttg ttagaacgtt accaagaatt cttagaaaat aagctagcac
    38701 ttgtttaata tcctgtaaaa aacgaatatt aaccctggaa atatcatatt ttcagggtct
    38761 ttctatttaa aatgtggtaa actatataga aaaggacatc gtatttaact tagaaactga
    38821 cgtgattaga aaggaatctt atgactcatt caatttggca tgagaaaatc aaatcatttt
    38881 tgccggagca ttactatggt cgcatcaatc actttttaga tgaagcctat gcttccggtc
    38941 ttgtctaccc ccaacgagaa aatgtcttta aagccttaca agtgactcct ttggaagaaa
    39001 ccaaagtgtt gattttagga caagaccctt atcatggtcc caaacaggcc cagggcttat
    39061 cattttcagt tccagaagag atttctgctc cgccatccct tattaatatt ttaaaagaat
    39121 tagcagatga cattggtcct cgtgaccatc atgatttaag cacttgggct agtcaagggg
    39181 ttctgctttt gaatgcttgc ttaacagtgc cagcaggcca ggctaatggg catgcaggct
    39241 taatatggga gccatttaca gacgctgtta ttaaagtgct gaatgaaaaa gacagccctg
    39301 tagttttcat tttgtggggt gcttatgcaa ggaagaagaa agccttcatt actaattcaa
    39361 agcaccacat catcgagagc cctcatccaa gccctttgtc atcttatcgt ggcttttttg
    39421 gcagcaaacc cttttcaaga accaacgcta ttttagaaaa agagggcatg actggcgtag
    39481 attggctaaa ataagccagc catttcaact aaatagctta agctagacat tttgatacct
    39541 ttaataagtg aaatgagcgc agtagatttt tcctattaaa gaacgtaagg tcttatggtt
    39601 aaaacagata aataaaggag aaaacatgat actcatcaaa aatggacgcg ttatggaccc
    39661 gaaatcgcag agagatcaag tggcagatgt cttgattgat ggtaaacaga ttgtaaagat
    39721 agcttcagct attgaatgcc aagaagctca agtgattgat gctagtggtc ttattgttgc
    39781 cccgggtttg gtcgatattc atgtgcattt tagagaaccc ggtcaaacgc acaaagaaga
    39841 tattcacacg ggagccttgg cagcagcagc aggtggtgtg actacggttg tcatgatggc
    39901 taataccaat cctgtcattt cagatgtcga aactttacag gaagtgctag ctagcgcagc
    39961 taaagaaaag attcatattt acaccaatgc cagtgtcacc caagccttta atggaaaaga
    40021 cgtgactgat tttaaagctt tgttggaagc aggagcagta agcttttcag atgatggtat
    40081 tcccttagaa agttctaaag ttttaaaaga agcctttgat ttggctaatg ccaaccaaac
    40141 tttcatttct ttgcatgagg aagatcctca gttaaatggg gttcttggtt ttaatgaagg
    40201 tattgctgag gagcattttc atttttgtgg ggcaactggt gtagcagaat atagtatgat
    40261 tgcaagagat gtcatgattg cttatgacag gcaagctcat gttcatatcc aacatttatc
    40321 taaagcagaa tcggttcaag tagtggcttt tgctcagcag ttgggtgcta aggtaactgc
    40381 tgaagtgtcc ccacaacatt tttcaacaac tgaagatctc ttattgaccg caggtaccag
    40441 cgccaagatg aatcctcccc ttcgtacaca aagagatcgc ttagctgtca tagaaggctt
    40501 gaaatcaggt gttatcacag tcattgccac tgatcatgct cctcatcaca aggatgaaaa
    40561 agctgttgat gatatgacta aagccccatc tggtatgaca ggacttgaaa cttctttgtc
    40621 attaggtttg acgcatttgg ttgaaccagg tcatcttaca cttatgtcac tattagaaaa
    40681 aatgacgctt aatccagctt tgctttatgg ttttgatgcg ggttatttgg cagaaaatgg
    40741 tccagcagat ttggttattt ttgcagacaa gcaagaacgt ctgatcactg agaactttgt
    40801 ttctaaagct agtaattccc catttattgg taacaaactc aaaggtgtcg tgaaatacac
    40861 tattgcagac ggagaggttg tttaccctaa ttaacaaatg agttaaaaca aaaaagcctg
    40921 actttcagag aaagtcaggc ttttagtaaa tttatttttt aggcacttgt ttgcttaaat
    40981 ttagccccca aggtattaga ttttcagtat gatgtttgat acgactaatg ttatctttgt
    41041 gtcttataat aataatgaac gcaagtaata tcacaataaa agttaaaaag tagtcataat
    41101 ttggtaaaag aaaatgaatg gcaggaaatg ttaaaacaga taacacacca acgatagctg
    41161 aaaccacact agctaaagat atcatactaa ataaatagag aactaaaaca aagatagatg
    41221 ctaaaaaaaa gagatataac ggagcaaagc ctagcaatac accagcactt gttgctacgg
    41281 ccttaccacc tttaaagttg gcaaaaatag gaaaagtatg ccctaaaact gcgaaaaagc
    41341 cgatagcaat ggatgaaatt gaagtcatac caaaaataat tggtaacaat attgaaagtg
    41401 tccctttaaa catatcaata gctaaggtag ctgttcctgc cttgacacct aaaatccgaa
    41461 aagtatttgt ggttccagta tttcctgatc catgctctcg taagttgatg tggtaaaagt
    41521 actgtccaat ccatagtcca gttggaatag aaccaagtaa ataggcaatg gtaataaaaa
    41581 gtagtaattt cataatcctt attataacat attcatagat tggagaacta gatctggaaa
    41641 agaattcgga aaaaattagc aaattatttt gcaaaattgg taaaaaactt gtaagataaa
    41701 aaagatgaaa ctgtctggag gtcggtgttg actaagaaag aaattacaat taataattat
    41761 aatgacgatg ctatccaagt cctagaaggg ttagatgctg ttcgcaagcg tccagggatg
    41821 tatatcggtt caacagatgc tacgggattg caccacctga tttgggaaat tgttgataat
    41881 gctgtcgatg aggccttgtc tggttttgga gatgatatta aggttgttat caataaagat
    41941 ggctcggtca gtgtggcaga tagcggacgt ggaatgccaa caggtcagca tgccatgggg
    42001 attcccaccg ttcaagttat ttttacgatt cttcatgcag gtggtaaatt tggtcagggt
    42061 ggctacaaaa cgtcaggtgg tttgcacggt gttggctcct ctgttgtcaa tgctttgtct
    42121 gcctggttag aagtcgaaat cacaagagac ggggcagtgt atcgtcagcg ctttgaaaat
    42181 ggggggaaac ctgttacaac ccttaaaaaa gttggcacag ctcctaagtc taaatcagga
    42241 acggttgtaa cctttatgcc tgatgataag attttttcaa ctattgactt taagttcaat
    42301 accatttcag aacgattgaa agaatctgct tttcttttga aaaatgtcaa gatgagcttg
    42361 acagatcttc gtggagatga cccgattatt gaagagtttc attatgaaaa tggggttcaa
    42421 gatttcgtcg aatacctcaa tgaagataag gaaaccttga cacctgttat ttacatggaa
    42481 ggtcaagacc aagactttca agtcgaggtt gctttgcagt ataacgatgg tttttccgac
    42541 aatatcttat cctttgtaaa caatgtgcgc accaaagatg gtggaagcca tgaaacggga
    42601 ctaaagtcag ctattaccaa agcgatgaat gactatgctc gtaaaaccaa tctcttaaaa
    42661 gaaaaggata aaaatctaga gggctcagat tatcgagaag gactctcagc agtattatct
    42721 atcttagttc ctgagcagca cttgcaattt gaaggacaga ccaaagacaa attgggaagt
    42781 cccttagcga gacctattgt agagagcatt gtttctgaaa aattaacctt ctttttactc
    42841 gaaaatggag aagtagcttc tcatctagtt cgcaaagcca ttaaagctag agatgctcgc
    42901 gaagctgctc gaaaagcgcg tgatgactca cgtaatggta agaaaaacaa aaaagacaaa
    42961 ggcttgttgt cgggaaaatt aaccccagct cagtccaaaa atgccaagaa aaatgaattg
    43021 tatctggtcg aaggagattc tgcgggaggt tcagccaaac aaggacgaga ccgcaaattt
    43081 caggctattt taccattacg tggcaaagtt ttaaataccg aaaaagctaa aatggctgat
    43141 atcttgaaaa atgaagaaat taacactatg gtttatacca ttggagctgg agtgggagct
    43201 gactttaacc tcgaggatat caactatgat aagattatta tcatgaccga tgctgatacc
    43261 gatggggctc atattcagac tcttttgctg actttctttt accgttacat gcgaccattg
    43321 gtagaagccg gtcatgttta cattgccctt ccacctcttt acaaaatgtc aaaaggcaaa
    43381 ggcaaaactg aaaaaattgc ttatgcttgg actgatggtg aattagaaga tctgcgcaga
    43441 gaatttggca agggggctat tcttcaacgc tataaaggac tgggtgaaat gaatgctaac
    43501 caattatggg aaaccactat ggaccctgaa accaggaccc ttattcgtgt tactattgac
    43561 gacttggcaa gagcagagcg acgtgtttct gtgttgatgg gtgacaaagc agccccacgc
    43621 cgtcagtgga tcgaggataa cgtcaagttt accttagaag aaaatacggt gttttagtca
    43681 tacaagtttc tcacagataa ttacaagtgc taaagacgat tgttttttag gtaattaata
    43741 aataatgaaa aagaaagcta tttgaatatg tcaaacattc aaaacatgtc ccttgaggat
    43801 attatgggag aacgcttcgg ccgttattcc aagtatatta ttcaggaacg ggcgcttcca
    43861 gatattcgag atggattgaa acccgttcag cgtcggattc tttattcgat gaataaggat
    43921 ggcaatactt ttgaaaaagg ttaccgtaaa tcagccaaat cagttggtaa tattatgggg
    43981 aatttccacc cgcatgggga ttcctctatt tatgatgcca tggttcggat gagtcaagat
    44041 tggaagaacc gtgaaatcct tgttgaaatg cacggaaata atggttcaat ggatggcgat
    44101 ccgcctgcgg ctatgcgtta tacagaagct cgcttgtctg aaattgcagg ttatcttctt
    44161 caagacattg agaaaaatac ggtctctttt gcgtggaact ttgatgacac agaaaaagaa
    44221 cccaccgttt taccagcagc ttttcctaac ttacttgtca atgggtcttc tggtatttcc
    44281 gcaggctatg cgacagatat tccaccgcac aatttgtcag aagtgattga tgctgttgtg
    44341 tatatgattg atcatcccaa agctagttta gagaaattga tggaattttt gcctgggcca
    44401 gatttcccaa caggaggtat tatccaagga gctgacgaaa tcaaaaaagc ctacgaaaca
    44461 ggcaagggac gtgtcgttgt tcgctctagg acagaaatcg aggaacttaa aggtggtaaa
    44521 caacaaatta ttgtcactga gattccttat gaagttaaca aagcagtctt ggtcaaaaag
    44581 attgacgatg tgcgtgttaa caataaagtc ccaggcatcg tagaagtacg cgatgaatct
    44641 gatcgcacag gtcttcgcat agctattgag ttgaaaaaag aggctgatag ccaaaccatt
    44701 ctaaattatt tgttgaaata cacagatctt caagttaatt ataattttaa tatggttgct
    44761 attgatcact ttacgccacg ccaagtaggt cttcaaaaaa tcttatcaag ctatatcagc
    44821 caccgcaaag atattattat tgagcggtct aaattcgata aagccaaagc tgaaaaacgc
    44881 ctccacattg ttgaaggatt gattcgtgtc ttgtccatct tagatgagat tattgctttg
    44941 attagatcgt ctgacaataa ggctgatgct aaagaaaatc tgaaagtcag ctatgatttc
    45001 tctgaggaac aagcagaagc gattgtaacc ttgcagcttt atcgtttaac taataccgat
    45061 attgttactc tccaaaatga agaaaatgat ttaagagact taatcacgac cctgtccgct
    45121 attatcggtg acgaagcaac catgtataac gtcatgaaac gtgaattaag agaagtgaaa
    45181 aagaaattcg ccaatcctcg tttatcagag ttacaagcag aaagtcaaat cattgagatt
    45241 gacactgcca gcttgattgc agaggaagaa acttttgtta gtgtgacacg gggcggatac
    45301 ctcaaaagaa ccagcccacg atccttcaat gcgtctagtt tggaagaagt tggcaagaga
    45361 gatgatgacg aactcatctt cgttaaacag gccaaaacaa cagaacacct tttgttgttt
    45421 acaactttag gcaatgtcat ttaccggcca atccatgaat tgaccgattt acgttggaag
    45481 gatatcggtg aacatttatc acaaactatt tcaaacttcg cgacagaaga agagattctc
    45541 tacgctgata ttgtgacttc ctttgaccag ggcttgtatg tggctgtcac acaaaatggt
    45601 tttatcaaac gctttgatcg taaagaacta agtccttggc gaacttataa atctaaatca
    45661 accaaatatg tgaagctaaa ggatgacaaa gaccgcgtgg ttaccttgtc accagttatt
    45721 atggaagacc tcctattagt gactaaaaat ggttatgctt tgcgattctc cagtcaggaa
    45781 gtgcctattc aagggttgaa atctgctggt gttaaaggca ttaacttgaa aaatgatgac
    45841 agccttgcct cagcctttgc tgtgacaagt aactctttct ttgtcttaac tcagaggggt
    45901 tctctcaaac ggatggctgt cgatgatatt cctcagacaa gtcgtgccaa tcgtggacta
    45961 ttggtcctac gagagttaaa aaccaaacct catagagttt ttctggccgg aggcgttcaa
    46021 tcagatactt cagctgagca gtttgatttg ttcactgata tacctgaaga agaaactaat
    46081 caacaaatgc ttgaagtcat tagtaagact ggtcaaacct acgagattgc tttagaaacg
    46141 ctttcgttat cggaaagaac cagcaatggc tcctttattt cagacactat ttcggatcaa
    46201 gaagtactgg tagctagaac acgttaaaaa gagtgaaaac tctttttaat tttatggtaa
    46261 atttagaata ttaatgcaaa agaatagaat aaacttgaaa attattgaaa aaaagttaca
    46321 atagaaaaaa gcagaaaaga ggtacgatga tgacaatagc aattgattgg gacaacctag
    46381 gatttgaata tcataagttg ccgtttcgtt acatttctta ttacaaaaat ggtcaatggg
    46441 ataaaggtca attaacagaa gatgccacct tacatatctc agaaagcgct ccagcgcttc
    46501 attatggaca acaagctttt gaaggtttaa aggcttatcg caccaaagat ggctctatcc
    46561 aactatttag accagaccgt aatgcagcgc gtttacaagc cacagcagac cgcttgttga
    46621 tgccacaagt atcaacagag caatttattg atgcagctaa gcaagtggtt aaagccaatg
    46681 aagactttgt accaccttac ggaacaggtg caacgcttta cctgagaccg ttattaattg
    46741 gagttggagg tattattggg gttaaaccag ctgaagaata tattttcacc atttttgcca
    46801 tgccagtagg aaactatttc aaaggtggac ttgctccaac taattttatt gtttctgaag
    46861 cgtttgaccg cgccgctcct tacggaacag gtgctgctaa ggtgggagga aactatgcag
    46921 gaagtttgct accaggtaag gccgctaaat cagcaggctt ttctgatgtg atttacttag
    46981 atccagcaac ccatactaaa attgaagaag tcggagctgc aaactttttt ggcattactg
    47041 caaataatga atttgttacg ccacttagtc catccatctt gccatctatt acgaagtatt
    47101 cactcttaca actagctgaa gaaagacttg gtatgacagt aattgagggt gatgttccaa
    47161 ttaatgaatt ggataaattt gtggaagcag gagcttgtgg aacagcagct gttatctctc
    47221 caattggcgg tatccagtac aaggataact tacatgtctt ttacagtgaa acagaagttg
    47281 gtcctgtgac acgccgttta tacgatgagt tggtcggcat tcaatttggg gatattgaag
    47341 caccagaagg ttggattgta aaagtagatt aaaatagagc ttgctcttgc aagctttcag
    47401 actgaagaca aagtccttag aatcactttt ctaggggctt ttcatgatat ttaggagtat
    47461 aatataagaa aaaggacttg tgaggttctc ctatgttaca caaagaaaaa cctgattata
    47521 accgcaatca gtacggtttc tatacccttg accagttagt gcctgatgaa catttcctgc
    47581 gccaagtgga agctgtgatt gacttcgact tcatctatga cctagtagaa gacacctatt
    47641 cgtctgataa tggtcgccct agccttgatc ctgtcatgtt ggttaaaatc c
//
LOCUS       DAUDWO010000012        44212 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.012, whole genome shotgun sequence.
ACCESSION   DAUDWO010000012 DAUDWO010000000
VERSION     DAUDWO010000012.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 44212)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44212)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44212
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.012"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            366..800
                     /locus_tag="VHC05_000612"
     CDS             366..800
                     /locus_tag="VHC05_000612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401944.1"
                     /translation="MTKKNHGVFWGLLLGSAAASIAYLSLSSSKKDQLLKNSAKKLDD
                     LNAYLQDKSKQVLDAVSEKVQESKDAVEVYGGIAAETVEEKWQDTKDAVEVYGGIATE
                     TVEESLGQVKEKVEGIGEATSQTIQSKMEKLTSDKTDADDEK"
     gene            complement(850..1761)
                     /locus_tag="VHC05_000613"
     CDS             complement(850..1761)
                     /locus_tag="VHC05_000613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
                     /protein_id="HEQ5401945.1"
                     /translation="MKTVRIFYNPNSGKKEDQLAGQVKDYFCQHGFSEDSVEIITPKD
                     ADQAFQLAKQAAKDKIDLVIPLGGDGTLNKIIGGIYEGGAQCLIGLVPSGTVNNFAKA
                     MHIPLQITEALDTILTGQIKQVDICKANQQYMISSLTLGLLADIAADVTAEEKRRFGP
                     LAFLKDSIRILKRNRSYAISLISHNHRIHLKTKFLLITMTNTIAGFPSFSPGAQADDG
                     YFQVYTMKKVSFFKFLWHINDFKQGDFSKAEEISHFQANTLSLLPQAKKQAILPRARI
                     DGDKSDYLPIQLDIIPKAISIIVPTED"
     gene            complement(1878..2528)
                     /locus_tag="VHC05_000614"
     CDS             complement(1878..2528)
                     /locus_tag="VHC05_000614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin III family protein"
                     /protein_id="HEQ5401946.1"
                     /translation="MNQTFKQSLPLSFSEEVANSVTHAIGAFAMLILLPISASYAYQT
                     YDLKAAIGISIFVISLFLMFLSSTIYHSMAYGSVHKYILRIIDHSMIYIAIAGSYTPV
                     ALSLVSGWLGYIIIVLQWGITLFGILYKIFAKRINEKFSLMLYIVMGWLVVFILPVII
                     QKTSLAFGLLMLFGGLSYTIGAVFYAKKRPYFHMIWHLFILLASALQFIAITFFML"
     gene            complement(2525..2965)
                     /locus_tag="VHC05_000615"
     CDS             complement(2525..2965)
                     /locus_tag="VHC05_000615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1836 domain-containing protein"
                     /protein_id="HEQ5401947.1"
                     /translation="MIFPSLPYWKDLPDLDLYLDQVLLYVNQCTDFSEVSDNKSLTAS
                     MINNYVKHGYVTKPIKKKYQKQQLARLIAISLFKTVFPIQDISRVLEELQAQADSESL
                     YNTFVTCWNQKAPIEEDIPPIVQVACQTVKDYHKTIYLSQEVTQ"
     gene            3184..4032
                     /gene="ylqF"
                     /locus_tag="VHC05_000616"
     CDS             3184..4032
                     /gene="ylqF"
                     /locus_tag="VHC05_000616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="HEQ5401948.1"
                     /translation="MAMIQWFPGHMSKARRQVQENLKHVDFVTILVDARLPLSSQNPM
                     LTKIVGDKPKLMILNKADLADATRTKEWKAYYESQGIKTLAINSKEQSTVKKVTEAAK
                     ELMADKIKRLRDRGIQKETLRTMIIGIPNAGKSTLMNRLAGKKIAVVGNKPGVTKGQQ
                     WLKSNKELEILDTPGILWPKFEDELVGLKLALTGAIKDQLLPMDEVTIFGLNYFKTHY
                     PSRLTKRFKNIPLEEEAPEIIMTLTRQLGFKDDYDRFYSLFVKEVRDGKLGQYTLDQV
                     GDMDAD"
     gene            4022..4813
                     /locus_tag="VHC05_000617"
     CDS             4022..4813
                     /locus_tag="VHC05_000617"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HII"
                     /protein_id="HEQ5401949.1"
                     /translation="MPTSIKAIKESLEAVTSLLDPLFQELATDARLGVQKALKSRQKA
                     IQTDLAEEERLEAMLSYEKALYKKGYQAIAGIDEVGRGPLAGPVVAACVILPKYCKIK
                     GLNDSKKIPKAKHETIYQAVKEKALAIGIGIIDNQLIDEVNIYEATKLAMLEAIKQLE
                     GQLTQPDYLLIDAMTLDIAISQQSIIKGDANSLSIAAASIVAKVTRDQMMANYDRIFP
                     GYGFAKNAGYGTKEHLQGLKAYGITPIHRKSFEPVKSMCCDSTNP"
     gene            4878..5714
                     /gene="dprA"
                     /locus_tag="VHC05_000618"
     CDS             4878..5714
                     /gene="dprA"
                     /locus_tag="VHC05_000618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-protecting protein DprA"
                     /protein_id="HEQ5401950.1"
                     /translation="MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGC
                     KHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYPMALKEIYNPPVLLFFQGNLDLL
                     EKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
                     AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGIL
                     VVEAKNRSGSLITCQIGIEEGRDIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILS
                     EY"
     gene            5821..7950
                     /gene="topA"
                     /locus_tag="VHC05_000619"
     CDS             5821..7950
                     /gene="topA"
                     /locus_tag="VHC05_000619"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I DNA topoisomerase"
                     /protein_id="HEQ5401951.1"
                     /translation="MGTKTTTKPKTGTKKSTTKKKSTAKKNLVIVESPAKAKTIEKYL
                     GRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKAAKKVYL
                     ASDPDREGEAISWHLSHILGLDPQDNNRVVFNEITKDAVKHAFVEPRQIDMDLVDSQQ
                     ARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENDIKAFVPKEYWSIDG
                     LFKKGTKKFQATFYGINGKKTKLDNNNDVKEVLAKLTNEDFLVSKVDKKERRRNAPLP
                     YTTSSLQQDAANKINFRTRKTMMVAQQLYEGIHLGENGTQGLITYMRTDSTRISPVAQ
                     NDAAQFIINRFGANYSKHGNRVKNTSGAQDAHEAIRPSSVNHTPDSIAKYLNKDQLKL
                     YTLIWNRFVASQMTAAVFDTVKVNLEQNGVIFVANGSQMKFDGYMAVYNDSDKNKKLP
                     EMAEGETVKKISTSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYY
                     VKLSAKRFEPTELGEIVNKLIVEFFPDIVDVAFTAEMEGKLDQVEIGEEQWQHVIDQF
                     YQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGHPMVIKLGRFGKFYACSNFPECRNT
                     KAITKEIGVTCPVCHKGQVIERKTKKNRIFYGCDQYPDCEFISWDLPIGRACPKSGDY
                     LIEKKVRGGKQVMCSNETCDYKEEKIK"
     gene            complement(8026..8910)
                     /locus_tag="VHC05_000620"
                     /pseudo
     CDS             complement(8026..8910)
                     /locus_tag="VHC05_000620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000354842.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
     gene            8923..9489
                     /locus_tag="VHC05_000621"
                     /pseudo
     CDS             8923..9489
                     /locus_tag="VHC05_000621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015631865.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit IIC"
     gene            9504..10496
                     /locus_tag="VHC05_000622"
     CDS             9504..10496
                     /locus_tag="VHC05_000622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-lactate dehydrogenase"
                     /protein_id="HEQ5401952.1"
                     /translation="MKLKLYNVRGEEAVLAKKWADDNGIEISLTESSLTPETVKEAEG
                     FDGIANAQIGPLDDAIYPLLKEMGIKQIAQRSAGVDMYNLDLATENDIIITNVPSYSP
                     ESIAEFTVTIALNLIRHVELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLAT
                     AKIFKGFGFKVVGYDIYQSDAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNA
                     DLFKSFKKGAILMNMARGALIETQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQE
                     ITDSLFKALINHPKVIYTPHAAYYTDEAVKNLVEGALNATVEIIKTGTTTTRVN"
     gene            10601..11266
                     /locus_tag="VHC05_000623"
     CDS             10601..11266
                     /locus_tag="VHC05_000623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SatD family protein"
                     /protein_id="HEQ5401953.1"
                     /translation="MTYIALIGDIIQSKQLTDRSKVQKTLAAYLDDLNKTFAPYIISK
                     LSLTLGDEFQGLFQVDTPIFHLIDLINHHMDIPIRFGVGVGSILTDINPDISIGADGP
                     AYWHAREAIRYIHQKNDYGNTTLALRTGHHNQDDVLNSLLAAGDAIKASWRASQWEIF
                     DTLLDLGIYEEYFDQQRLGKQLSLSSSALSKRLKSSHVKIYLRTRQSALNCLKQIKEE
                     ADD"
     gene            11259..11975
                     /locus_tag="VHC05_000624"
     CDS             11259..11975
                     /locus_tag="VHC05_000624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3307 domain-containing protein"
                     /protein_id="HEQ5401954.1"
                     /translation="MINGVSHYLAQTPTLTLFLICHVLSDYQLQSQQVADLKEKHVTY
                     LGYHLIGVSIPLICLTLIIPQAWLMSLLVMISHALIDWLKPKMANSLKWKREWIFLLD
                     QCLHIAISSFAGLRLAGVTLPNWLPISILMTVLFILLITKPTNIVFKLFFSKYQPDQG
                     EKMDTIIGAEATIGILERIVIGVCMIMGQFASIGLVFTAKSIARYNKISESPAFAEYY
                     LIGSLFSILSVFIAAWICFF"
     gene            12126..13472
                     /gene="trmFO"
                     /locus_tag="VHC05_000625"
     CDS             12126..13472
                     /gene="trmFO"
                     /locus_tag="VHC05_000625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate--tRNA-(uracil(54)-
                     C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO"
                     /protein_id="HEQ5401955.1"
                     /translation="MSQSTATYINVIGAGLAGSEAAYQIAKRGIPVKLYEMRGVKATP
                     QHKTTNFAELVCSNSFRGDSLTNAVGLLKEEMRRLDSIIMRNGEANRVPAGGAMAVDR
                     EGYAESVTAELENHPLIEVIRDEITEIPDDAITVIATGPLTSDALAEKIHALNGGDGF
                     YFYDAAAPIIDKSTIDMSKVYLKSRYDKGEAAYLNCPMTKEEFMAFHDALTTAEEAPL
                     NAFEKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQ
                     LRQDNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLL
                     TETFQSRSNPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKREEALIFPQTTAIGS
                     LPHYVTHADSKHFQPMNVNFGIIKELEGPRIRDKKERYAAIASRALADLDTCLASL"
     gene            13625..15031
                     /locus_tag="VHC05_000626"
     CDS             13625..15031
                     /locus_tag="VHC05_000626"
                     /EC_number="6.4.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011527649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate carboxylase subunit B"
                     /protein_id="HEQ5401956.1"
                     /translation="MIQFGGFSMQQQVAITETVLRDGHQSLMATRLSIEDMLPVLTIL
                     DKIGYYSLECWGGATFDACIRFLNEDPWERLRTLKKGLPNTRLQMLLRGQNLLGYRHY
                     ADDIVDKFISLSAQNGIDVFRIFDALNDPRNIQQALRAVKKTGKEAQLCIAYTTSPVH
                     TLNYYLSLVKELVEMGADSICIKDMAGILTPKAAKELVSGIKAMTNLPLIVHTHATSG
                     ISQMTYLAAVEAGADRIDTALSPFSEGTSQPATESMYLALKEAGYDITLDETLLEQAA
                     NHLRQARQKYLADGTLDPSLLFPDPRTLQYQVPGGMLSNMLSQLKQANAESKLEDVLA
                     EVPRVRKDLGYPPLVTPLSQMVGTQAAMNVILGKPYQMVSKEIKQYLAGEYGKTPAPV
                     NEDLQKSQIGSTTLTTNRPADQLNPEFEVLKAEIADLAQTDEDVLTYALFPSVAKTFL
                     TTKYQTDDVIKVTAFIKA"
     gene            15074..15388
                     /locus_tag="VHC05_000627"
     CDS             15074..15388
                     /locus_tag="VHC05_000627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401957.1"
                     /translation="MTYSFIDILQVTLVSLFLVLTCLTGIMGLMMLSGKLLSQEKPLL
                     PQASPKSLQDKEATQASGEALETLLAKDELARIAVMTSLAYASQEESGKRFEVVAVER
                     KS"
     gene            15388..15738
                     /locus_tag="VHC05_000628"
     CDS             15388..15738
                     /locus_tag="VHC05_000628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003057661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin/lipoyl-binding protein"
                     /protein_id="HEQ5401958.1"
                     /translation="MKRYEVTVNGQVYEVSLRELADGETVEVSQSAAPATEKEMNTNA
                     AGGGLQVKAPMSGTVLSIFATEGKAVKKGEAVLVLEAMKMENEILAPADGLVSKIHVV
                     ANQTVESEQVLISF"
     gene            15748..16878
                     /locus_tag="VHC05_000629"
     CDS             15748..16878
                     /locus_tag="VHC05_000629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium ion-translocating decarboxylase subunit
                     beta"
                     /protein_id="HEQ5401959.1"
                     /translation="MLDVLNQMVQSSGLAHLTVNNLIMICLACFFLYLGIKKEYEPYL
                     MVPIAFGILLVNLPMAGLMDHPANGNPGGLLYYLYKGTSLGIYPPLIFLCLGASTDFG
                     PLIANPKTILLGGAAQVGIFLAFFLAIMLGMTPQEAASVGIIGGADGPTAIYVTTKLA
                     PDLLSTIALAAYSYMALVPIIQPPIIKLLTTKAERQVKMTQARTVSQKEKIIFPIMVT
                     IFVSLLVPSATTLVGCLMLGNLVREIKIVPKIVENLQQVVMFCITIILGLTVGAKANG
                     DLFLSATTLKIIALGLIAFAAGTAGGVLMGKIMYYLSGNKVNPMIGAAGVSAVPMAAR
                     VVQKVGQEEDPSNFLLMHAMGPNVAGVIGSAIASGALLAFFG"
     gene            complement(17079..17963)
                     /gene="citG"
                     /locus_tag="VHC05_000630"
     CDS             complement(17079..17963)
                     /gene="citG"
                     /locus_tag="VHC05_000630"
                     /EC_number="2.4.2.52"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="triphosphoribosyl-dephospho-CoA synthase CitG"
                     /protein_id="HEQ5401960.1"
                     /translation="MTKAVLTSISQLALKALLYEVSLSPKPGLVDRFDNGAHDDMSFM
                     TFIDSMIALSPFFQAYIETGFAYAKEEPLLLFNRLRQLGQKAEETMFCATQGINTHKG
                     LNFSMALLLGATGAYLARTPHLMTDLGRFSKEDTLAICRLVKPMTAHLIQTDLGHLNT
                     KKEFTYGEQLFVTYGIKGPRGEASEGFTTLTDHALPYFRQMISQNDPETSQLRLLVYL
                     MSIVEDGNLIHRGGIEAWKGVKADMRLLLQQDLSTTDLRLALSSYNQCLINQHLSPGG
                     AADLLALTFYFAFLEKLL"
     gene            complement(17956..18651)
                     /locus_tag="VHC05_000631"
     CDS             complement(17956..18651)
                     /locus_tag="VHC05_000631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEQ5401961.1"
                     /translation="MNPIIEAVKQNLDLSRNIPLKIAFYNALKKTIILRQIPVGSRIN
                     EKEFSIALNISRTPIRYALGLLSEEHLVEHIPKKGIIVKGVSIKDACEIFEIRKALET
                     LATVQAMHLMTEEDFKVMHNLLEDCETFIAEDDTNRILDNFNAFNNLIYSYSQMVRLK
                     EIVTELQTYLVYFRKISISSVERRKRALSEHWMIYRGMKNKDHEQITLITHEHLNSSL
                     EFILKEMRPEQND"
     gene            complement(18809..20212)
                     /locus_tag="VHC05_000632"
     CDS             complement(18809..20212)
                     /locus_tag="VHC05_000632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003088270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CitMHS family transporter"
                     /protein_id="HEQ5401962.1"
                     /translation="MLLTMLAYAMIIVFMYVVMKKKMTPFTALVMIPLIMTIAVILTG
                     SADFNADAKFVAFVGDGGIAKDLTAIGPMVMYGINNTAKTGIMLLFAILFFSVMLDAG
                     LFDPITEKMIRFAKGDPMKVLIATAVVAAAVSLNGDGTTTTLICCSAFLPIYKKLDMK
                     IMNLGVLIILQNTIMNLLPWGGPTARAMSVLGVGPEILGYLAPGMILSLLYVICWVAP
                     SMGRKERARLGVIDLSEEDMRQLTDITDPDTLFIRRPKNFVFNAILTIGLITWLVAGS
                     FNKSIAMAPLLLFAVGTCIALMVNYPVLKDQSKRIGDNAGDAVQVVILVFAAGIFMGL
                     FQGSGMASALAQSFATIIPKQLAGFWGLVIALVSAPGTFFISNDGFYYGILPVLAEAG
                     AEYGFSNMAMALASLMGQAFHLLSPLVAFIYLLLRLTGLDMGEWQKEAAKYALIIFVI
                     FVVTIIAMGQMPLYIPQ"
     gene            20592..20915
                     /locus_tag="VHC05_000633"
     CDS             20592..20915
                     /locus_tag="VHC05_000633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401963.1"
                     /translation="MQFLQKWFKHSKKEKLKESSPLSTEIEPSENWEKIPAYIPADKS
                     DYKKVTLITSAIAAGDRPNSQFKVKRILKRNPEAITVSLIASSIAAGVYPESQFRVTS
                     IYCKR"
     gene            20972..21367
                     /locus_tag="VHC05_000634"
     CDS             20972..21367
                     /locus_tag="VHC05_000634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="HEQ5401964.1"
                     /translation="MLRKFKITIDGKEYLVEMEEIGAPAQAAAPAQPISTPVPVPTEA
                     SPQVEEAQAPQPVAAAGADAIPSPMPGTILKVLVAVGDQVTENQPLLILEAMKMENEI
                     VASSAGTITAIHVGQGQVVNPGDGLITIG"
     gene            21412..22533
                     /locus_tag="VHC05_000635"
     CDS             21412..22533
                     /locus_tag="VHC05_000635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019323213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium ion-translocating decarboxylase subunit
                     beta"
                     /protein_id="HEQ5401965.1"
                     /translation="MDTLIAGITSITIPQIVMMVIGALLMYLGIKKEYEPTLLVPMGL
                     GTILVNFPGSGVLTQVVNGVEQEGVFEALFNFGIGTELFPLLIFIGIGAMIDFGPLLQ
                     NPFMLLFGAAAQFGIFFVVVVAVLAGFDIKEAASIGIIGAADGPTSIFVANQLAKDLL
                     GPITVAAYSYMALVPIIQPFAIKLVTTKKERRIRMTYKAENVSQMTKILFPIIITLVA
                     GFIAPISLPLVGFLMFGNLLRECGVLDRLSQTAQNELVNIISILLGLTISIKMQADLF
                     LNVQTLLIIVFGLLAFIMDSIGGVMFAKFLNLFRKEKINPMIGAAGISAFPMSSRVIQ
                     KMATDEDPQNFILMYAVGANVSGQIASVIAGGLLLAYFS"
     gene            22721..23029
                     /gene="citD"
                     /locus_tag="VHC05_000636"
     CDS             22721..23029
                     /gene="citD"
                     /locus_tag="VHC05_000636"
                     /EC_number="4.1.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="citrate lyase acyl carrier protein"
                     /protein_id="HEQ5401966.1"
                     /translation="MDIKQTAVAGSLESSDLMITVSPNDEKTITITLDSSVEKQFGNH
                     IRQLIHQTLVNLKVTAAKVEAVDKGALDCTIQARTIAAVHRAAGVDQYDWKEIDSWNV
                     "
     gene            23017..23904
                     /gene="citE"
                     /locus_tag="VHC05_000637"
     CDS             23017..23904
                     /gene="citE"
                     /locus_tag="VHC05_000637"
                     /EC_number="4.1.3.34"
                     /EC_number="4.1.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="citrate (pro-3S)-lyase subunit beta"
                     /protein_id="HEQ5401967.1"
                     /translation="MERLRRTMMFVPGANAAMLRDAPLFGADSVMFDLEDSVSLKEKD
                     TSRALVHFALKTFDYSSVETVVRVNGLDSCGALDIEAVVLAGVNVIRLPKTETAQDIV
                     DVEAVIERVERENGIEVGRTRMMAAIESAEGVLNAREIAKASKRLIGIALGAEDYVTN
                     MKTRRYPDGQELFFARSMILHAARAAGIAAIDTVYSDVNNTEGFQNEVRMIKQLGFDG
                     KSVINPRQIPLVNEIYTPTEKEIDHAKQVIWAIREAESKGSGVISLNGKMVDKPIVER
                     AERVIALATAAGVLSEEDI"
     gene            23907..25439
                     /gene="citF"
                     /locus_tag="VHC05_000638"
     CDS             23907..25439
                     /gene="citF"
                     /locus_tag="VHC05_000638"
                     /EC_number="2.8.3.10"
                     /EC_number="4.1.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="citrate lyase subunit alpha"
                     /protein_id="HEQ5401968.1"
                     /translation="MVTNKLGRDIPQPYADQYGVFEGELANIKQYDESSRRIKPVKPG
                     DSKLLGSVREAIEKTGLTDGMTISFHHHFREGDFIMNMVLEEIAKMGIKNLSIAPSSI
                     ANVHEPLIDHIKNGVVTNITSSGLRDKVGAAISEGLMENPVVIRSHGGRARAIASGDV
                     HIDVAFLGAPSSDAYGNVNGTKGKATCGSLGYAMIDAKYADQVVILTDNLVPYPNTPI
                     SIPQTDVDYVVTVDAIGDPQGIAKGATRFTKNPKELLIAEYAAKVITNSPYFKEGFSF
                     QTGTGGASLAVTRFMREAMIKENIKASFALGGITNAMMELLEEGLVEKILDVQDFDHP
                     SAVSLGKHAEHYEIDANMYASPLSKGAVINQLDTCILSALEVDTNFNVNVMTGSDGVI
                     RGASGGHCDTAFAAKMSLVISPLIRGRIPTFVDEVNTVITPGTSVDVVVTEVGIAINP
                     NRQDLVDHFKSLNVPQFSIEELKEKAYAIVGTPERIQYGDKVVALIEYRDGSLMDVVY
                     NV"
     gene            25432..26010
                     /gene="citX"
                     /locus_tag="VHC05_000639"
     CDS             25432..26010
                     /gene="citX"
                     /locus_tag="VHC05_000639"
                     /EC_number="2.7.7.61"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="citrate lyase holo-[acyl-carrier protein]
                     synthase"
                     /protein_id="HEQ5401969.1"
                     /translation="MCRDTYFSGEAIQLSDMLRAREERALRQLHLLKEYPEGSLLSVT
                     MNIPGPIKTSPKLLEAFDIVIKAIQTALADDKICYQLRLLPTTGYEYYLITSLPSRDL
                     KLKMIALETELPIGRLMDLDVLVLQNDLPHSISRTVLGGSPRQCFICSKEAKVCGRLR
                     KHSVEEMQTAISKLLHSFFNKDNQSSSSDKTG"
     gene            26025..27419
                     /locus_tag="VHC05_000640"
     CDS             26025..27419
                     /locus_tag="VHC05_000640"
                     /EC_number="4.1.1.112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxaloacetate decarboxylase subunit alpha"
                     /protein_id="HEQ5401970.1"
                     /translation="MTKIRITETVLRDGQQSQIATRMTTKEMIPILETLDNAGYHALE
                     MWGGATFDSCLRFLNEDPWERLRAIRKAVKKTKLQMLLRGQNLLGYRNYADDVVRSFI
                     QKSIENGIDIVRIFDALNDPRNLQTAVSATKKFGGHAQVAISYTTSPVHTIDYFVELA
                     KAYQAIGADSICIKDMAGVLTPEIGYQLVKCIKENTTIPLEVHTHATSGISEMTYLKV
                     AEAGADIIDTAISSFSGGTSQPATESMAIALTDLGFDTGLDMQEVAKVAEYFNTIRDH
                     YREVGILNPKVKDTEPKTLIYQVPGGMLSNLLSQLAEQGLADKYEEVLAEVPKVRADL
                     GYPPLVTPLSQMVGTQALMNIISGERYKVVPNEIKDYVRGLYGQSPAPLVEGIKEKII
                     GDEAVIACRPADLIEPQMIYLRDEIAQYARSEEDVLSYASFPQQARDFLGRREDPFYD
                     VPVQEVTVQLDIQD"
     gene            complement(27529..28581)
                     /gene="citC"
                     /locus_tag="VHC05_000641"
     CDS             complement(27529..28581)
                     /gene="citC"
                     /locus_tag="VHC05_000641"
                     /EC_number="6.2.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[citrate (pro-3S)-lyase] ligase"
                     /protein_id="HEQ5401971.1"
                     /translation="MPYYTISKVFPSDKTTMASVKNLLHQEGIRLDAHLDYTCAIMNA
                     QNDVIATGSYFGNSLRCLCVSSAYQGEGLLNRIVSHLIDEEYTLGNYHLFVYTKTSSA
                     AFFKDLGFTEIVHIDNHISFLENKKTGFQDYLMTLNKPEQTPGKVAAVVINANPFTLG
                     HQFLVEKAARENDWVHLLMVSEDRSLIPFSVRKRLIQEGLAHLDNVIYHETGPYLISQ
                     ATFPAYFQKEDNDVIKSQALLDTAIFLKIAQTLQITKRYVGEEPTSRVTAIYNEIMAE
                     QLQQAGILLDILPRKAINQQQDPISASTARQALKDNDWDLLAKLLPKTSLDYFCSLEA
                     QPIIKKIQATSSVKHY"
     gene            complement(28670..29152)
                     /locus_tag="VHC05_000642"
     CDS             complement(28670..29152)
                     /locus_tag="VHC05_000642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PASTA domain-containing protein"
                     /protein_id="HEQ5401972.1"
                     /translation="MPKRIRKALGVVGKLMSIVPDTTEIIGKTIDNSRPIIEKRMEQK
                     HEKEMQLRTIDDVINLPVDQAQAHLEQLGFVVATIPAKPHKKWLHSNLNEVVAMSPKS
                     GKYKIGSLIKLYYITVDVLEKSQDLLDQENLRTVERNQKIADTFESVKHIRFPFKKWR
                     "
     gene            complement(29852..30922)
                     /gene="xerS"
                     /locus_tag="VHC05_000643"
     CDS             complement(29852..30922)
                     /gene="xerS"
                     /locus_tag="VHC05_000643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012658412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine recombinase XerS"
                     /protein_id="HEQ5401973.1"
                     /translation="MRRELLLEKIETYKAIMPWYVLDYYQSKLAVPYSFTTLYEYLKE
                     YKRFFDWLMDADLTQAPKIADIDLSTLEHLTKKDLEAFVLYLRERPSLNTYSTKEGLS
                     QTTINRTLSALSSLYKYLTEEVENDQGEPYFYRNVMKKVSTKKKKETLASRAENIKQK
                     LFLGDETLAFLDYVDKEYEQKLSNRAKSSFRKNKERDLAIIALLLASGVRLSEAVNLD
                     LKDVNLNMMIIEVIRKGGKRDSVNVAGFAKGYLESYLAVRQRRYKAEKQDLAFFLTEY
                     RGVPNRMDASSIEKMVGKYSEDFKIRVTPHKLRHTLATRLYDATKSQVLVSHQLGHSS
                     TQVTDLYTHIVNDEQKNALDNL"
     gene            31396..32094
                     /locus_tag="VHC05_000644"
     CDS             31396..32094
                     /locus_tag="VHC05_000644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5401974.1"
                     /translation="MFSGHQLKTARLSKGITQSELGRLLHVNKMTISNWEKGKNIPNE
                     KHLNALLHLFNVTSDYFDPNYRLLTPYNQLTISNKEKVIGYSERLLNHQINKKSKDLI
                     DKPSQLYAYRVYESLSAGTGYSYFGDGNFDVVFYDEQLEYDFASWVFGDSMEPTYLNG
                     EVVLIKQNSFDYDGAIYAVEWDGQTYIKKVFREDEGLRLVSLNKKYSDKFAPYSEEPR
                     IIGKIIANFRPLEI"
     gene            complement(32211..33773)
                     /gene="ffh"
                     /locus_tag="VHC05_000645"
     CDS             complement(32211..33773)
                     /gene="ffh"
                     /locus_tag="VHC05_000645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle protein"
                     /protein_id="HEQ5401975.1"
                     /translation="MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADV
                     ALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVNEELTSILGSETAEIDKSPKIPT
                     IIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPV
                     FDMGTDHSAVDIVRKGLEQARENRNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEI
                     LLVVDSMIGQEAANVAYEFNHQLSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGI
                     GEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLELAEKMRENTFDFNDF
                     IEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKFDENQIARKRAIVSSMTPAERENPD
                     LLNPSRRRRIAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMAKMMKDMGINPNNLP
                     KNMPAGMPDMSSLEGMMGQGGMPDLSGLNGDMDMSQLFGKGFKGKIGQFAMKQAMKRQ
                     ANKLKKAKKKRK"
     gene            complement(33788..34129)
                     /locus_tag="VHC05_000646"
     CDS             complement(33788..34129)
                     /locus_tag="VHC05_000646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="HEQ5401976.1"
                     /translation="MNIMEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEI
                     ADEFGVSRQAVYDNIKRTEKILETYEMKLHMYSDYVVRSEIFDDMIAHYPHDEYLQEK
                     ISILTSIDNRE"
     gene            complement(34218..34916)
                     /locus_tag="VHC05_000647"
     CDS             complement(34218..34916)
                     /locus_tag="VHC05_000647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000936162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEQ5401977.1"
                     /translation="MLPAYIKIHDAIKKDIDLGIWPIGSRLPSERHLAEYFTVSRMTL
                     RQAITLLVEEGILERRIGSGTYVASHRVQEKMRGTTSFTEIIRSQGRQPSSKLLSYQK
                     QLASDTEVKELNLDKTDLVIRMERIRYADSVPLVYEIASIPEKFIKTVKRADITEHFF
                     HSLIANGYEIGKSKQTIYAKLASERVASYLEVAKGHAILALTQVSYFTDGKPFEYVRS
                     QYIGDRFEFYLENN"
     gene            complement(34999..36432)
                     /locus_tag="VHC05_000648"
     CDS             complement(34999..36432)
                     /locus_tag="VHC05_000648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401978.1"
                     /translation="MLSKKRILGLFRPVELIFLGLLLSLVVSYLAWTNSFATLHNILA
                     TVGIVERSKDQQPRYHIGQAIQVQKSGPYHQWIGTINKQVEDIAENYRVSYHYEVVFP
                     IGKVTVSLPEHNLKEPDKPRFKKGDIVKLSSLTKKPHIKVYQGQLATIKQVKKRYDYS
                     LGGYQYDINLKDNLRLDGISEQDFVKPYYIRFNKGNSPEQNNRLLRKAFAYAKQHPNS
                     VISFPKGQFHIGSLPSQKDYFELPSDTAIIGHQTEFIIHGKMLWFGFPTGPKAEQGVR
                     NLVLTGVHFKANDLKKGDHFMIMADHGTDWHIYDNKFTMVHKRNSHIFDLGSLQNSLF
                     EKNQFIGYAPELVQDQQLLSKAQGHDFFSEVIQFDAAVHHFAWDGGLLSNIAPNYEAF
                     NQTRHLCHNITVSQNQFLPYIDPTGCLRAYSGSIGQHSSKVGVIRVLNNVFTSSIVTK
                     AKLTSWFMEPIHFPPNSPVIVAGNIIN"
     gene            36599..38161
                     /gene="guaA"
                     /locus_tag="VHC05_000649"
     CDS             36599..38161
                     /gene="guaA"
                     /locus_tag="VHC05_000649"
                     /EC_number="6.3.5.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="HEQ5401979.1"
                     /translation="MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKI
                     TAQELREINPIGIVLSGGPNSVYADNAFGIDPEIFELGIPILGICYGMQLITHKLGGK
                     VVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSND
                     CPYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEIAK
                     IRETVGDRKVLLGLSGGVDSSVVGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLG
                     GKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDEASKLKGVDFLAQGT
                     LYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEI
                     VWRQPFPGPGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVR
                     SVGVMGDGRTYDYTIAIRAITSIDGMTADFAQLPWDVLKKISTRIVNEVDHVNRIVYD
                     ITSKPPATVEWE"
     gene            complement(38203..39426)
                     /locus_tag="VHC05_000650"
     CDS             complement(38203..39426)
                     /locus_tag="VHC05_000650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyltransferase"
                     /protein_id="HEQ5401980.1"
                     /translation="MTNLTFYAKIGISEEEHDSFVKEHQQISVLQGSDWAKIKNQWQN
                     ERIGIYKEEKQVASLSLLIKLLPLGRSIIYIPRGPVMDYLDRDLVAFTMKTLKDYGKT
                     KKALFIKYDPAILLKQYALGQEEEEKPLALAAIKNLQEAGVHWTGLTMEIADSIQPRF
                     QANIYTQENLEMQFPKHTRRLIKDAKQRGVETYRASQSELHKFSKIVSLTEKRKNISL
                     RNEAYFQKLMTTYGDKAYLHLAKVNIPQKLDQYRQQLILINQDITRTQAHQKKRLKKL
                     EDQKASLERYITEFEGFTDQYPEEVVVAGILSISYGNVMEMLYAGMNDDFKKFYPQYL
                     LYPKVFQDAYQDGIIWANMGGVEGSLDDGLTKFKANFAPTIEEFIGEFNLPVSPLYHI
                     ANTMYTIRKQLKNKH"
     gene            complement(39791..41335)
                     /locus_tag="VHC05_000651"
     CDS             complement(39791..41335)
                     /locus_tag="VHC05_000651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEQ5401981.1"
                     /translation="MSILEVKQLSHGFGDRAIFENVSFRLLKGEHIGLVGANGEGKST
                     FMSIVTGHLQPDEGKVEWSKYVTAGYLDQHTVLESGQTVRDVLRTAFDELFKTENRIN
                     EIYASMADDKADIAVLMEEVGELQDRLESRDFYTLDAKIDEVARALGVMDFGMESDVT
                     SLSGGQRTKVLLAKLLLEKPDILLLDEPTNHLDAEHIEWLKRYLQHYENAFVLISHDI
                     SFLNDVINIVYHVENQSLVRYTGDYYQFQAVYEMKQSQLEAAYERQQKEIANLQDFVN
                     RNKARVATRNMAMSRQKKLDKMDIIELQAEKPKPNFEFKQARTPSRFIFQTKNLVIGY
                     DYPLTKEPLNITFERNQKIAIVGANGIGKSTLLKSLLGVIEPLEGHIVTGDFLEVGYF
                     EQEVTGVNRQTPLEVVWDAFPALNQAEVRAALARCGLTSKHIESQIQVLSGGEQAKVR
                     FCLLMNRENNVLILDEPTNHLDIDAKNELKRALKAYKGSILMVCHEPDFYNGWVTDTW
                     DFSKLT"
     gene            complement(41469..42026)
                     /locus_tag="VHC05_000652"
     CDS             complement(41469..42026)
                     /locus_tag="VHC05_000652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEQ5401982.1"
                     /translation="MSSQKLANYIELSMYAALIFISVQVLRVPVGMQFIHLGNALVVI
                     AVLIYGSKKGALVASLGLGIFDVLNGYASVVWITILESLAICLILHLVYERAMQSSKK
                     PKAIITITVIAALSKLTINLIKYLLLAYIGTQLPLSVSFWVALGKIGGSFGTSFVTLV
                     AVPLLYPVIKNLKEKVTIGQAKRGF"
     gene            complement(42004..42870)
                     /locus_tag="VHC05_000653"
     CDS             complement(42004..42870)
                     /locus_tag="VHC05_000653"
                     /EC_number="2.7.1.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine kinase"
                     /protein_id="HEQ5401983.1"
                     /translation="MKRIIVANDLVGVGKVALSASIPLMASCLLEQVLLPTCLLSSHT
                     GGGQSPVKHTTSSILDVFLTDWDNKRIKFDGIFIGYFTTTRDGQKLLEWLSRKQLPLI
                     LDPIMADNGKLYQGFSQKHIEIMIKLTQKAELVLPNISEACLLTQTAYLAKNYDEEDI
                     RQVARKLAKLGPKQVVISGISFEEGSIGFAYYQSDSDQLTFHFGKQFPYHFYGTGDIA
                     SAIITAGFYYQLPLTQILDLVVSFLEKVLQNTLTLKRDLILGVAYESHLNYLTKSFKK
                     LLEEKNVISKIS"
     gene            42960..>44212
                     /locus_tag="VHC05_000654"
     CDS             42960..>44212
                     /locus_tag="VHC05_000654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HEQ5401984.1"
                     /translation="MTTKYQTIISNIEQDIQKQRLKKGDKLPSIRVLSKVYHCSKDTV
                     QRALLELKYRHLIYAVPKSGYYVLGNVSMPDNVLNLSLEDYNNMAYEDFRLCLNEALS
                     AKDKYLFHYYHKTEGLEELREALLLYLAENSVYSNKDQLLITSGTQQALYILSQMPFP
                     NAGKTILLEKPTYHRMEAIVAQLGLPYQTISRHFNGLDLELLESLFQTGDIKFFYTIS
                     RFSHPLGLSYSTKEKEAIVRLAQRYQVYILEDDYLGDFVKLKEPPIHYYDTHHRIIYL
                     KSFSMSVFPALRIGALVLPSGLKPHFLTQKSLIDLDTNLLMQKVLALYLENGMFQKNL
                     RFIKRYLKQRERQLALFLKQNCPDIHYQLTPTHLVIDYTTSDSYRNFTLDKSDRIIIT
                     GKKRYLSIAINQQIQSKLNSLIKNT"
BASE COUNT        13816 a         8381 c         8424 g        13591 t
ORIGIN      
        1 ttgttgaaat gttttcgtat taatgttttt ttatctattg cgatagataa ttttacttca
       61 atttttgatt gaaaatacta aaataagtga tgtggtcact ttgacaacca tttattggtc
      121 cttttagata agacaatttt gtggctcttc agttgaaagg atgtgttgtt gatgttagag
      181 gaaacaatca tgttaaatta actcaggctt aaagaccaaa aaaggagtga agtctattat
      241 gaaaaaaaga aattttaaac ttacagaaat gttacaattg gttttattag tggttcctgc
      301 tgtaaaactt gctaaaaaaa tgtttaacga tagtaaaaca ccgtctaaaa gaaagtaggt
      361 ctacaatgac taaaaaaaat catggcgttt tttgggggtt gttgcttgga tcagcagcag
      421 ctagcattgc ttacttaagt ttatcgtctt ccaaaaaaga tcaactcttg aaaaatagtg
      481 ctaaaaaatt agatgatctc aacgcttact tgcaagataa aagtaagcaa gttctggatg
      541 cagtatcgga aaaagtacaa gaatccaaag atgctgttga agtttatggt ggtattgccg
      601 cagaaaccgt tgaagaaaag tggcaagata ccaaagatgc tgttgaagtt tacggtggta
      661 ttgccacaga aacagttgaa gaatctttgg gacaggttaa agaaaaggta gaaggaattg
      721 gcgaagctac tagccaaact atccaatcta aaatggaaaa actcaccagc gataagacag
      781 atgctgatga tgaaaaatag gttttaaaat acctttaaga taagacaaaa agtgccatta
      841 ggcacttttt taatcttctg ttggaacaat aatcgaaatg gcttttggaa tgatatctaa
      901 ttgaatgggc agatagtcac ttttatcccc atcaatcctg gcacgtggta atatcgcttg
      961 ttttttagct tgtggtagta agctaagcgt attggcttga aaatgactga tttcctctgc
     1021 tttggaaaaa tcaccctgtt taaaatcatt aatatgccat aaaaatttaa agaaagagac
     1081 ttttttcatg gtataaactt ggaaatagcc atcgtcagct tgagcaccag gagaaaaaga
     1141 aggaaaacca gcaatggtat ttgtcatcgt gattaagaga aacttcgttt tcaggtgaat
     1201 acgatggttg tggctaatta aagagatggc atagctgcga tttcgtttca gtattcgaat
     1261 actatctttt aaaaatgcta gaggaccaaa gcgtcgtttt tcctcagccg ttacgtcggc
     1321 agcaatatca gccagtaatc ctaaggttaa actggaaatc atgtattgct ggttagcttt
     1381 gcaaatatca acttgcttga tttgtcccgt caagatagta tccaacgcct cagtaatttg
     1441 taaagggata tgcatagcct tggcaaaatt attgactgtc cctgagggca ctaagcctat
     1501 taaacattga gctcctcctt catagatgcc accgatgatt ttgtttagtg tcccatcgcc
     1561 accaagaggg ataaccaagt caatcttgtc cttagcagct tgttttgcta attgaaaagc
     1621 ctggtcagca tctttagggg taataatctc tacagaatct tcggaaaaac catgttggca
     1681 aaaatagtct ttgacttgcc cggcaagttg gtcttctttc tttccagaat taggattgta
     1741 aaaaatccga acggttttca tcaggtctct cctttgacag cttattactt gctatccatt
     1801 ataccacttc taagaattga tgtcttacac caactcatca cattaagcct ctcaatcagt
     1861 ctgagcatct atttgtccta aagcataaag aaagtgatag cgataaattg gagggcagag
     1921 gccaataaaa taaagagatg ccaaatcatg tggaagtagg gtcttttttt ggcataaaat
     1981 accgctccaa tggtataaga caagccacca aataacatga gaagaccaaa agcaagacta
     2041 gttttttgaa tgatgactgg caagataaac acaacgagcc agcccataac gatataaagc
     2101 atcaaactga atttttcatt gatacgtttg gcaaaaattt tgtataaaat cccaaaaagc
     2161 gtaatgcccc actgcaaaac aataatgata tagcctagcc aaccagaaac aagggataaa
     2221 gcaacaggtg tataacttcc tgcgatagca atgtaaatca tactgtgatc aataatgcgt
     2281 agaatgtatt tgtgaaccga accataagcc atggagtggt aaatcgtaga ggacaaaaac
     2341 atcaaaaaga gactgatgac aaagatggag ataccaatag cggctttaag gtcataagtt
     2401 tgataagcat agctggctga aataggaagt agaatgagca tagcaaatgc tccgatagcg
     2461 tgtgtcacgc tgtttgctac ttcctcacta aaagataagg gtaaactttg tttaaaggtt
     2521 tggttcattg ggtcacctcc tgtgataaat aaatagtttt gtggtaatct ttgaccgttt
     2581 gacaggcaac ctgcacaatc ggtggaatgt cctcctcaat gggagctttc tgattccaac
     2641 aggttacaaa agtattgtag agactttcag aatcagcctg tgcctgaagt tcctccaata
     2701 cgcgactaat atcttgaata ggaaataccg ttttaaacaa actgatggca attaagcgcg
     2761 ctagttgttg cttttgatat tttttcttga taggtttagt cacataccca tgcttgacgt
     2821 aattattaat catagatgcc gttagtgatt tattatctga cacttctgaa aaatcagtgc
     2881 actggttgac ataaagtaac acttgatcca aatataagtc taaatcaggg aggtccttcc
     2941 aataaggtaa tgatggaaaa atcataggtt cgtctctcta tctagttttg ataactagat
     3001 tatatgatta atgaaaactt attgcaagca aaaactgtaa agacttaaaa gaggaaagta
     3061 gaaatggcga agtgaagcta atcatgctat aatgttaaag aattgattgg gatagatgcc
     3121 ttctgtcgca atcagactat tttatcacga agaagatgat gctacgaaag gaatgataca
     3181 ctcatggcaa tgattcaatg gtttcctggg cacatgtcca aagccagaag acaggttcag
     3241 gaaaatttaa agcatgttga ctttgtaact attttagtgg atgcacgctt gccactttct
     3301 agtcaaaatc ccatgctcac caaaattgtt ggtgataaac ctaaattaat gattttaaat
     3361 aaagctgact tggcagatgc aactcgaact aaagagtgga aagcctacta tgaaagtcaa
     3421 ggcattaaaa cactagccat caattctaaa gaacaatcaa cagttaaaaa agtaacagaa
     3481 gcagccaagg aactcatggc tgataaaatt aagcgcctgc gtgatcgtgg tattcaaaaa
     3541 gaaaccttgc gaaccatgat tattggcatt ccaaatgctg gtaaatctac cttgatgaat
     3601 cgcttggctg gtaagaaaat tgctgtggtt ggtaataaac ctggtgtgac caaagggcaa
     3661 caatggttga agtccaataa ggaattggaa attctagata cccctggtat tttatggcca
     3721 aaatttgagg acgaattggt tggcttaaaa ttagctttaa caggtgctat caaggaccaa
     3781 ttactaccaa tggatgaggt cactattttt ggtttgaatt actttaaaac acattatcct
     3841 agtcgcctta ctaagcgttt taagaatatt cctcttgagg aagaagctcc tgaaatcatt
     3901 atgaccttaa cacgtcagct tggctttaaa gatgattacg accgtttcta cagtttattc
     3961 gttaaggaag ttcgtgatgg taaattaggt caatacacct tagatcaggt gggagatatg
     4021 gatgccgact agtattaaag ctattaaaga aagcttagag gccgttacta gcctcttgga
     4081 ccccctcttt caagaattgg caactgacgc taggttaggc gtccaaaaag cgctaaaaag
     4141 tcgacaaaag gctattcaga ccgatttagc agaggaagaa cgattagaag ccatgctttc
     4201 ttatgaaaaa gcgctttata aaaaaggtta tcaagccatt gcaggtattg acgaggtggg
     4261 acgtggtccc ttagcaggtc ccgttgtggc agcttgtgtg attttaccta agtattgtaa
     4321 aattaaaggc cttaatgatt ctaaaaaaat ccctaaagct aagcatgaga ccatttatca
     4381 ggcagtgaaa gaaaaagctt tggctatcgg tatcggtatt attgacaatc agctgattga
     4441 tgaggtcaat atttatgaag caaccaaact agctatgcta gaagccatta aacagttgga
     4501 gggccaactc acacagccag attatctctt gattgatgcc atgacattgg atattgctat
     4561 ttcgcagcag tctattatta aaggcgatgc caattccttg tctattgcag cagcatcaat
     4621 tgtagctaag gtcaccagag atcagatgat ggctaactat gatcgcattt ttcctggtta
     4681 tggctttgct aaaaatgcag gctatggcac caaagaacat ttacaaggat taaaagctta
     4741 cggcataacg cctatccatc gtaaaagttt tgaacctgtt aaatccatgt gctgcgattc
     4801 aactaatcct taaaaagttc tgtttttagc agaatttttt tcttttttac gaataaatga
     4861 agtaaggagg taacttagtg aatcattttg aactttataa gctaaagaaa gctggactga
     4921 ctaataaaaa cattctcaat attcttgact accaagaaca ccaggaaaaa tcgttgtcac
     4981 ttcgagatat ggccgttgtt tctggttgta agcatccgtc tcactttata gaagcctata
     5041 agcagttaga tattcaaaaa ttaaaaatgg aatttaaaca atttcctagt atttctatct
     5101 tagataagca ttacccaatg gcattgaaag aaatatacaa tccacctgtc ctcttgtttt
     5161 ttcagggaaa tttagacctt cttgagaaac ctaaattagc cattgttggc tccagacgct
     5221 caagcgatac cggagtaaag tctgtccgta aaattcttaa agaactcggg aaccgttttg
     5281 tgattgttag cggacttgct cgaggtatcg acactagtgc tcatttagcc tgccttaaaa
     5341 atgggggaca aaccatcgct attattggaa cagggttgga tcgcttttac cctaaagaaa
     5401 atagggagtt gcaaactttc ttagggaaaa atcatcttgt gctaacagaa tacggtccaa
     5461 gagaagaagc tttatcttat cactttccag aacggaatcg tattatcgca ggccttagcc
     5521 gaggtattct tgtcgttgaa gcaaaaaatc gttcaggttc cttgattact tgtcaaattg
     5581 ggatagaaga aggccgagac atttttgctg tcccaggaaa cattttggac gggaaatccg
     5641 aaggttgcct tcagttaatt aaagagggag caacatgcgt cacatcgggc atggatatcc
     5701 tttcagagta ctaaaaaagt taaagtttct tcctatatag cattttttta ttgacagttt
     5761 cttaaaaatg ggatattatg ctataagctt taaacaaact gttataggaa gtgtgtcgaa
     5821 ttgggaacaa aaactacaac taagccaaaa acgggtacta aaaagtccac cactaaaaag
     5881 aaatcaacag cgaaaaaaaa tctcgttatt gttgaatcac ctgccaaagc taagactatt
     5941 gaaaaatatc ttggacgcag ttataaagtt gttgcttcgg taggacatat tcgtgactta
     6001 aaaaaatcgt ctatgtctat tgattttgat aataattatg agccacaata cattaatatc
     6061 cgtggtaagg gaccccttat caattcttta aaaaaagaag ccaaagctgc taaaaaagtt
     6121 tatttagcta gtgacccgga tcgtgaggga gaggctattt cttggcattt gtcacatatc
     6181 ttaggacttg atcctcaaga taataaccga gtggttttta atgaaattac gaaagatgca
     6241 gttaaacatg cctttgtgga gcctcgtcag attgatatgg acttggtaga ttctcaacaa
     6301 gcacgtcgtg ttttggaccg tattgtggga tattccattt caccaattct ttggaaaaag
     6361 gtcaaaaaag gactttcagc aggacgtgtc cagtcggttg ctttaaaact catcattgac
     6421 cgtgaaaatg acatcaaagc atttgttcca aaggaatact ggtctattga tggtcttttt
     6481 aaaaaaggaa ctaaaaagtt tcaagcgact ttttacggta ttaatggcaa aaaaacaaag
     6541 cttgataata acaacgatgt caaagaggta ttagcaaagc taacaaatga agattttctt
     6601 gtcagcaagg ttgacaagaa agagcgacgt cgtaatgctc ccttacctta cacaacatca
     6661 tctcttcaac aagatgctgc taataaaatc aatttcagaa cgcgtaaaac catgatggta
     6721 gcccaacaac tgtatgaggg gattcattta ggagaaaatg gaactcaagg tttaattacc
     6781 tatatgcgta cggattctac tcgtatcagt ccagtagcac aaaacgatgc tgctcaattt
     6841 attatcaatc gctttggagc taattattca aaacatggta atcgtgtcaa aaataccagt
     6901 ggtgcccaag atgctcacga ggcgattcgt ccatctagtg ttaatcatac gccagactct
     6961 attgccaaat accttaacaa ggatcagtta aaactttata cgcttatttg gaatcgtttt
     7021 gtggctagcc aaatgacagc agctgttttt gataccgtaa aggtgaactt ggaacaaaat
     7081 ggcgtgattt ttgttgccaa tggtagccaa atgaagtttg atggttacat ggctgtttac
     7141 aatgattccg ataaaaacaa aaagttacct gagatggcag aaggagaaac tgttaaaaaa
     7201 atatcgacct ctccagaaca gcactttacg cagccaccag ctcgttattc tgaagcaact
     7261 ctgattaaaa cgctagaaga aaatggtgtt ggacgtccat caacttacgc tccaacctta
     7321 gaagtcattc aacgcagata ctatgttaaa ttgtctgcta agcgctttga gccaactgag
     7381 cttggggaaa ttgtcaacaa gcttattgtc gaatttttcc cagatattgt tgatgttgcc
     7441 tttactgccg agatggaagg taagctagat caagttgaaa tcggagaaga acaatggcaa
     7501 catgttatag atcaattcta tcaacccttt gtcaaagaat tgaataaggc tgagtctgaa
     7561 atcgaaaaga ttcaaatcaa agatgaacca gctggtttcg actgtgatgt ttgtggtcac
     7621 ccaatggtca ttaagttagg acgttttggg aaattttacg cgtgtagcaa cttcccagag
     7681 tgccgtaata caaaagcaat cactaaagaa attggtgtta cttgtccggt ttgtcataaa
     7741 ggacaagtta tcgagcgtaa aaccaaaaaa aataggatat tttatggttg tgatcagtat
     7801 ccagattgtg agtttatctc gtgggattta cctattggac gtgcttgccc taagtcaggt
     7861 gactatctta ttgagaaaaa agttcgtggt ggcaaacaag taatgtgtag caatgagacc
     7921 tgtgattaca aggaagaaaa aattaaataa aaaaagaatt ggaactcctt gtcttgttcc
     7981 aattcttttt tttatttaca aaggtatttt taactacaaa aatcgctagt tcgtttttaa
     8041 aaggcttaaa aattcctcaa taactggact gaaactcgca tcatctcggt aagcaatccc
     8101 aatagggtaa aaattatttt tatcttgcaa aggaatccaa actaagttat ctacctgatt
     8161 aagactctca aaatcactcg ggaggatagt caaggcattc aaatcgtgca aactatgaat
     8221 aagaacttcc caatcattgt gtttaaagac aatatctgat tcaaaaccga gagctcggca
     8281 ttttctagga agcatttcgc ctagcatgta gtgatcgttt aaagaagcaa tcttatagcc
     8341 ttttaaatct ttaagtttta actgaggatg ttgcgccaaa gggtgctgtt tgaggagaac
     8401 gatactgacc ttatagcctt ttgtggacgt ttgtaatagc tcaatggtaa tatcctttcg
     8461 aatacttaga aaggagagga gatcaatatc gatttttcct tgggacaata attcttataa
     8521 tttgcgagaa ccatcctgta taagcgataa ttcaacattt gagtgagtag ccataaagat
     8581 tgaaatttgt ttcatgaatt gtatagcaaa cagtgatgtt aattcaacac gaatcatctc
     8641 tttttttctt gatttaattg ctgaatatcc gcaacaattt gattaaagtc atccacaagg
     8701 tctttgcctt tgtgataaag aatatctcca gcttcggtta gtagtagctg tcaatcactt
     8761 tgtgtaaaaa gcgtcgtgtt caaactagga ctctagcctt ttaattgatt gagaaagagt
     8821 aggttgcgtt acaaacaaac ttttagcagc gtgggaatga ttttttgttt cagcaactgc
     8881 aataaaatag gttaattgtc tagtgtccat agtagatcct tcatgattgg tcaaggaata
     8941 gcgtctctac ttggtttaca acctattttg atgtctctcc ttattgccat gattttctgc
     9001 ttccttattg tttctccaat tacaacggta ggaattgctc ttgcgattaa cttatctggt
     9061 attggttcag gtgctgcaaa cttaggtatt tgtgccgcaa gctttggact ttgcttagca
     9121 ggttgggctg ttaattcaaa aggaacttca cttgctcacg tcttgggatc accgaaaatt
     9181 tcaatggcca acgttttatc aaaaccaaaa atcatgttgc caatgttatg ttctgcagct
     9241 gtacttggtg ttattggtgc tatctttaat attcaaggaa cacctgctag tgcaggcttt
     9301 gggattagtg gtttgatcgg acctatcaat gcccttaatt tagctaaagg cggatggtct
     9361 ctagtaaata ttctacttat cattatcatt tttgtagggg caccaattgt tctcaatata
     9421 atctttaacc acctttttat caaggtgctt aaagtgattg atccaatgga ttacaaactt
     9481 gatatctaag aaaggaactt ttgatgaaat taaaattata taatgttaga ggcgaagaag
     9541 cagtcttagc aaaaaaatgg gctgatgaca atgggattga gatttccttg acagagtctt
     9601 ccttaactcc tgaaacggtt aaagaagctg aaggctttga cgggattgcc aatgcccaaa
     9661 ttggtccttt agatgatgcg atttatcctc tcttaaagga aatggggatt aaacaaatcg
     9721 ctcagcgcag tgctggtgtc gatatgtata accttgattt ggccaccgaa aatgacatta
     9781 ttatcacaaa tgttcctagc tattctccag aatccattgc agaatttacg gttactattg
     9841 cccttaattt aattcgtcat gtggagttga ttcgtgaaaa tgttaaaaaa caaaatttca
     9901 cttggggact ccctatccgc ggccgtgttt taggtgatat gacagttgcg attatcggaa
     9961 ctggacgtat tggtctagct actgctaaaa tctttaaagg ttttggcttc aaggtcgttg
    10021 gatatgatat ttaccaaagc gatgctgcca aagctgtctt ggactataag gaatctgtag
    10081 aagaagcgat taaagatgct gatcttgttt ccttacacat gccaccaact gcagagaaca
    10141 cacacctttt caatgctgat ttatttaaat cattcaaaaa aggggctatt ttgatgaata
    10201 tggcgcgtgg tgctctcatt gagacgcaag atttactgga tgctttggat gcaggcttac
    10261 tgagcggagc tggtattgac acttacgaat ttgaaggacc ttatatacct aagaattttg
    10321 aaggtcaaga aattacagat tcactattta aagctttgat taaccatcct aaggttattt
    10381 atacgcctca tgcagcttat tatactgatg aagccgttaa aaacctagtt gaaggtgccc
    10441 ttaatgctac agtagagatt atcaaaactg ggacaacgac aactcgtgtt aactaacaac
    10501 tgatttgacg tccattataa aggaataatt tcaaaaattc ctttataatg gacttttttg
    10561 cattagtccg ttataataga ctgtaagaaa ggggactctt atgacatata tagcgcttat
    10621 tggagatatt atccagtcca aacaattgac ggatcgttcc aaagttcaaa aaactttagc
    10681 agcctattta gacgacctca acaaaacctt tgctccttat attatttcta aattatccct
    10741 aacgttggga gatgaatttc aaggactttt tcaggtggat actcctattt tccatctgat
    10801 tgatttgatt aatcatcaca tggatatccc tattcgattt ggagtaggag taggttctat
    10861 tctaacagac atcaatcctg atattagtat tggagctgat ggacctgctt attggcatgc
    10921 tcgtgaggct attcgttata ttcatcaaaa aaatgattat ggtaatacta cattagctct
    10981 tcggactggt catcacaacc aggatgatgt attaaacagt ttactagcag ctggagatgc
    11041 tattaaagcc agctggcgag ctagtcaatg ggaaattttt gacacgcttt tagatttggg
    11101 catttatgag gaatactttg atcaacaacg actaggaaag caattatctc ttagctctag
    11161 cgctttgtca aaacgtctaa aaagtagtca tgttaaaatt tatctgagaa cacggcagag
    11221 tgcgctaaac tgtctcaaac aaatcaagga ggaagctgat gattaatggt gtctctcact
    11281 acctagctca aacccctaca cttaccctgt ttctcatttg tcatgtgtta tcagactacc
    11341 agttacaaag tcagcaagta gctgatttaa aagaaaaaca tgtgacttat ttaggttacc
    11401 acttgattgg agttagcatt cccctaattt gtttaaccct cattatccca caagcatggt
    11461 tgatgagcct attggttatg ataagtcacg cgcttattga ctggctaaag ccaaagatgg
    11521 ctaactctct aaaatggaaa agagagtgga tttttctgct ggatcaatgc ttacatatcg
    11581 ctattagttc atttgctggg ctaaggttag caggggtgac cttgcctaat tggcttccga
    11641 tatctatttt gatgaccgtt ttatttatcc tactcattac caaaccaact aatattgtct
    11701 ttaaactctt tttcagcaaa taccagcctg accaaggaga aaaaatggac acgatcatag
    11761 gagcggaggc taccatagga attctagaga gaattgttat tggggtgtgt atgatcatgg
    11821 ggcaatttgc ttcaataggt ctggtcttta ccgctaaatc tattgctcgc tataataaaa
    11881 tttcggaaag tccagctttt gcagaatact acctaattgg ttctttattt agtattctca
    11941 gtgtttttat cgcagcatgg atttgtttct tctagttgaa aagggttccc gtagaaagag
    12001 gctaacgctt agtctctttc tttttctttc ttcttatttc tgttataata agtcaggtaa
    12061 ctacattaga aagatttgtg ggtctgtcat ctaagagatg tcattcccga agaggtatta
    12121 gtgacttgtc tcaatcaact gcaacttata ttaatgttat tggagctgga ctagctggtt
    12181 ctgaagctgc ctatcagatt gctaagcgcg gtatccccgt taaattgtat gaaatgcgtg
    12241 gtgtcaaagc aacaccgcaa cataaaacca ctaattttgc cgaattggtc tgttccaact
    12301 catttcgtgg tgatagctta accaatgcag tcggtcttct caaagaagaa atgcggcgat
    12361 tagactccat tatcatgcgt aatggtgaag ctaatcgtgt acctgctggg ggagcaatgg
    12421 ctgttgaccg tgaggggtat gcagagagtg tcactgcaga gttggaaaat catcctctca
    12481 ttgaggtcat tcgtgatgaa atcacagaaa tccctgacga tgccattacg gttatcgcga
    12541 cgggtccatt gacttcagat gccttggcag aaaaaattca cgcgctaaat ggtggcgacg
    12601 gattctattt ttacgatgca gcagcgccta tcattgataa atctaccatt gatatgagca
    12661 aggtttacct taaatctcgc tacgataaag gcgaagctgc ttacctcaac tgccctatga
    12721 ccaaggaaga attcatggct ttccatgatg ctctgacaac cgcagaagaa gcaccgctga
    12781 atgcctttga aaaagaaaag tattttgaag gctgtatgcc gattgaagtt atggctaaac
    12841 gtggcattaa aaccatgctt tatggaccta tgaaacccgt tggattggaa tatccagatg
    12901 actatacagg tcctcgcgat ggagaattta aaacgccata tgctgttgtg caattgcgtc
    12961 aagataatgc agctggaagc ctttataata tcgttggttt ccaaacccat ctcaaatggg
    13021 gtgagcaaaa acgcgttttc caaatgattc cagggcttga aaatgctgag tttgtccgct
    13081 acggcgtcat gcatcgcaat tcctatatgg attcaccaaa tcttttaacg gaaaccttcc
    13141 aatctcggag caatccaaac cttttctttg caggtcagat gactggagtt gaaggttatg
    13201 tcgaatcagc tgcttcaggt ttagtagcag gaatcaatgc tgctcgtttg ttcaaaagag
    13261 aagaagcact tatttttcct cagacaacag ctattgggag tttgcctcat tatgtgactc
    13321 atgccgacag taagcatttc caaccaatga acgtcaactt tggcatcatc aaagagttag
    13381 aaggcccacg cattcgtgac aaaaaagaac gttatgcagc tattgctagt cgtgctttgg
    13441 cagatttaga cacctgctta gcgtcgcttt aacactaaaa aagagttcct tttcagttga
    13501 gttgctgaag aggacttttt tatttgctga tttgagcgct agctatgcaa aagaatgcac
    13561 aaaaaataca tgaatagact atggtcacta gaagcaatat tatataatga atagtactca
    13621 ttagttgatt cagtttggag gttttagcat gcagcagcaa gtcgcaataa cagaaacagt
    13681 tttacgggac ggtcatcaaa gtttgatggc aacgcgttta tctattgagg atatgcttcc
    13741 tgtccttacc atcttagaca agattggtta ctattcccta gagtgttggg gaggagcaac
    13801 ctttgatgcc tgtattcgtt ttttgaacga agacccttgg gaaaggctgc gcacgttaaa
    13861 aaaaggctta cctaataccc gtttacaaat gttattaaga ggccaaaacc ttttaggcta
    13921 ccgtcattat gcagatgaca tcgttgataa attcattagt ttatcagctc aaaatgggat
    13981 tgatgttttc cgcatttttg atgccctaaa tgacccacga aatatccagc aagccttaag
    14041 agctgtgaaa aagacgggga aagaggctca actgtgtatt gcctatacaa ctagcccagt
    14101 gcacacgctt aactattacc tttctttagt gaaagaattg gttgagatgg gagctgattc
    14161 tatctgcatc aaagatatgg ctggtattct aactcccaaa gcggctaaag agttggtatc
    14221 tggtatcaaa gccatgacta acttacctct tattgtgcat acccatgcaa ctagtggcat
    14281 ttctcagatg acctatctag cagcagtaga agctggggct gatagaattg ataccgcttt
    14341 gtcacctttt agcgaaggca cttcacaacc tgctacagaa tctatgtatt tagccttaaa
    14401 agaagcaggt tatgatatca cattagatga aacgctactg gaacaagctg ctaatcacct
    14461 tcgtcaagcc cgccaaaagt atttagctga tggaactctg gacccaagtc ttctctttcc
    14521 agacccaaga acgctacaat atcaagttcc tggaggcatg ttatctaata tgctatctca
    14581 actgaaacaa gctaatgccg aatcaaaatt agaagatgtt ttagcggaag ttcctcgggt
    14641 aagaaaagac ttaggttacc caccgttagt aacgccactt agtcaaatgg tcgggactca
    14701 agctgctatg aatgtgattt tagggaaacc ttatcaaatg gtgtccaaag aaatcaaaca
    14761 atatttagca ggagaatatg ggaagacacc tgcacctgtc aatgaagacc tgcaaaagag
    14821 tcaaattgga tcaacaacac taaccactaa tcgtcctgca gaccagttga atcctgaatt
    14881 tgaagtattg aaggcagaaa tagcagattt agcccaaacg gacgaagatg tgctgaccta
    14941 tgctctcttc ccaagcgtag caaaaacatt tttaacaacc aaataccaaa ctgatgacgt
    15001 cattaaagtg actgccttta tcaaagcata gtaggctatc ttaatcagat agaaacaaaa
    15061 atatggagat caaatgacct attcctttat tgatatctta caagttacct tagtatcctt
    15121 gttcttagtg ttaacctgtt taacagggat tatgggatta atgatgctaa gtggtaaatt
    15181 attgtcacaa gaaaaacctc ttctccctca agcctctcct aagagtcttc aagacaaaga
    15241 agctacccaa gcgagtggag aagctctcga aacccttttg gctaaggatg aattagctag
    15301 gattgctgtt atgactagtc ttgcttatgc tagccaagaa gagtcaggaa aacgatttga
    15361 agttgttgct gtggaaagga aatcctaatg aaaagatatg aagtgactgt caatggacag
    15421 gtttatgaag tgagtttacg tgaactagct gatggagaaa ctgttgaagt tagccagtca
    15481 gcagcacctg ctactgagaa agaaatgaat accaacgctg ctggcggtgg cctacaggta
    15541 aaggctccaa tgtctggaac agtcttgtcc atctttgcta cagaaggaaa agctgttaaa
    15601 aaaggagaag ctgttctggt cttagaggcc atgaaaatgg agaatgaaat tctagcacct
    15661 gcagatggtc tggtttcaaa aattcatgtt gtggctaacc aaacggtcga gtctgaacaa
    15721 gttttgattt cattctagga ggaaaccatg ctagacgtac tcaatcaaat ggtccaatcg
    15781 tcaggattgg ctcatctaac tgttaataat cttatcatga tttgcttggc ctgtttcttt
    15841 ttataccttg gtatcaaaaa ggaatatgag ccttacctta tggtaccaat cgcctttggg
    15901 attttactcg ttaatttgcc tatggcggga ttgatggacc accctgccaa tggtaatcct
    15961 ggtggccttc tttattacct atataaggga actagcctag ggatttaccc acctttaatt
    16021 tttctttgtt tgggggcatc aactgacttt ggtcccttga ttgccaatcc taaaaccatt
    16081 ttactaggag gcgcagcaca agttgggatt ttcttagcct ttttccttgc tattatgtta
    16141 ggcatgacac ctcaagaagc ggcttctgtc gggattattg gtggtgccga tggaccaaca
    16201 gctatttatg tgacgacaaa gttggcgcct gatttactct ctactatcgc cctagcagct
    16261 tattcttaca tggctctggt acctattatt caacctccca tcattaaact cttgactacc
    16321 aaggcggaac gccaagtgaa aatgactcaa gcaagaactg tttcacaaaa agaaaaaatc
    16381 attttcccga ttatggtaac aatctttgtc agccttttgg ttccaagtgc tacaaccttg
    16441 gttggctgtt tgatgctggg aaatctggtc agagaaatta aaattgttcc taaaattgta
    16501 gagaatctcc aacaagtggt tatgttttgc attactatca ttttagggtt aaccgttggt
    16561 gctaaggcca atggagatct ctttttatca gccacaacct tgaaaattat tgcccttggg
    16621 ctaatcgcct ttgctgctgg gacagcaggg ggtgtcttga tggggaaaat catgtactat
    16681 ttatctggta acaaagtgaa ccctatgata ggagcagcag gtgtttcagc tgttccgatg
    16741 gcagcacgag tggtccaaaa ggtcggacaa gaagaagatc caagtaattt cttactcatg
    16801 cacgccatgg ggcccaatgt agctggcgtt attggctcag ccattgcctc aggtgccttg
    16861 ctggccttct ttggctaatt gtgaaaaagg attagtaaat taatcttaat aaatcattat
    16921 caggagttgg aagcaatcca gctccttttt tagtagaaag ctcgagtgat aaactattcc
    16981 aaaataatta taaaaaaaga ctgtcctgat tgtacggact atatcagttg acttttatag
    17041 tctagctgaa atagcagtgc aaaactaaga cactcgtttt aaagtagttt ttctaaaaaa
    17101 gcaaaataaa aggtcagagc caataaatct gccgcgcccc cagggcttaa atgctgatta
    17161 atgaggcatt gattgtagga ggacaaagcc aatcttaggt cagttgttga taaatcttgt
    17221 tgcaggagta gtcgcatatc tgccttaacg cctttccatg cttcaatccc tccacgatga
    17281 atcagatttc catcttcaac aatagacatc aaataaacaa gaagacgaag ctgactggtt
    17341 tcggggtcat tttgacttat catctgacga aagtagggca aggcatggtc tgttaaggtc
    17401 gtgaatccct cgcttgcctc accccgaggt cctttgatgc cataagttac aaaaagttgc
    17461 tccccataag tgaactcttt tttagtgttc aaatgaccaa ggtctgtttg aatcaaatgt
    17521 gccgtcatag gttttactaa acgacagata gctagagtat cttccttgct aaaacgccct
    17581 aaatcagtca ttaagtgagg tgttcttgct agataggccc cagttgcacc aagaagtaaa
    17641 gccatggaaa aattcaagcc tttatgagtg ttaattccct gagtagcaca aaacatggtt
    17701 tcctcggcct tttgacctag ttgtctaaga cggttaaaca gaagaagtgg ctcttctttt
    17761 gcataagcaa aacctgtttc gatataagcc tgaaaaaaag gagagagtgc tatcatactg
    17821 tcgataaagg tcataaagga catgtcatca tgggcaccgt tatcaaatcg atcaactaaa
    17881 ccaggttttg gagatagtga gacttcataa agcaaagctt ttaaggccag ttgactaata
    17941 cttgttagaa ctgccttagt cattttgctc aggcctcatt tcttttaaga taaattcaag
    18001 tgagctattc aagtgttcat gtgtaatcaa cgtaatttgc tcatgatctt tgttcttcat
    18061 acctcggtaa atcatccagt gttcagatag agctcgttta cggcgttcaa ctgaagaaat
    18121 cgaaattttt ctaaagtaga ccaaataagt ttgcaattct gtcacaattt cttttaagcg
    18181 gaccatttgg ctatagctgt aaatcaaatt gttaaaggca ttaaaattat ccaaaatacg
    18241 attggtgtca tcctctgcga taaaggtttc acagtcttcc aacaagttat gcatgacttt
    18301 aaaatcttct tctgtcatta aatgcatcgc ttgcactgtt gcgagagtct ctagagcttt
    18361 tcgaatttca aaaatttcac aggcatcctt gatactaact cctttgacaa taatgccttt
    18421 tttaggaatg tgctctacaa ggtgttcttc agacaataat cccaaagcgt agcgaatagg
    18481 tgtcctgcta atattaagcg caatggaaaa ctctttttca ttaatgcggc ttccaacagg
    18541 aatttgtcgc aaaataatgg tctttttaag agcgttataa aaggctattt tcaaagggat
    18601 atttcttgat aggtcaagat tttgtttaac ggcttcgata ataggattca tgtcatctcc
    18661 ttaatgctag tgtcctcact ttattatact taaatttgtg aaacattcca ataggactag
    18721 atgagttctg aaaaattaaa gccatgctca caaaaggaca tgactttaat catctcataa
    18781 ggaataaggt agtagtgtta tcgttggttt attgtggaat gtaaagtggc atttgcccca
    18841 tggcaataat ggttaccaca aagataacaa agatgataag ggcatattta gcagcctctt
    18901 tttgccattc tcccatatca agacctgtca agcgaagaag gaggtaaatg aaggcaacta
    18961 atggactaag taagtggaag gcttgtccca tgagggaagc aagtgccata gccatgttac
    19021 tgaaaccata ttcagcacca gcttctgcaa gaacaggcaa gataccatag taaaaaccat
    19081 cattggagat aaagaaggta ccaggtgcag aaactaaggc aataacgaga ccccagaaac
    19141 ctgccagttg ttttggaata atggttgcaa aactttgtgc aagagcgcta gccataccag
    19201 aaccttggaa aagacccata aagataccag cagcaaagac taagataacc acttgaaccg
    19261 catcaccagc attatcacca atgcgttttg attgatcttt aagcactggg taattgacca
    19321 tcaaggcgat acaagttccc accgcaaaaa gaagaagcgg tgccatagca atagatttgt
    19381 tgaaagagcc agcaactaac caagtgatta atccaatggt taagatagca ttgaaaacaa
    19441 agtttttagg acgacgaata aaaagggtat ctgggtcagt aatgtctgtg agttgacgca
    19501 tgtcttcttc agacaagtca ataacaccaa gtcttgcacg ttctttacgc cccatgcttg
    19561 gagcaaccca acaaatcaca taaagaagag ataaaatcat acccggtgca agatagccaa
    19621 gaatttcagg accgacacca agaacagaca tcgcacgagc agtagggcca ccccatggca
    19681 gtaagttcat aatagtattt tgaagaataa tcaagacacc taggttcata attttcatgt
    19741 ccaatttttt atagataggt aagaaagcag agcaacaaat taaagtagtg gttgttccat
    19801 caccattaag agatactgcg gcagcaacga cagctgttgc gataagcacc ttcattggat
    19861 cacctttagc aaagcgaatc atcttttcag taatcggatc aaacaatcct gcatctaaca
    19921 tgacagagaa gaacaaaatg gcaaatagca acatgatacc tgttttagca gtattgttga
    19981 taccatacat aaccattggt ccgatagctg ttaggtcttt agcaattcca ccgtcaccaa
    20041 caaaggcaac aaatttggca tctgcattga agtcagctga accagtcagt ataacagcaa
    20101 tcgtcatgat taatggaatc atgaccaaag cagtaaaagg ggtcattttt ttcttcatta
    20161 ccacgtacat aaagacaata atcatggcat aagccagcat tgttaataac atcattgtta
    20221 tctccttttt caagttatga tttcagtata gatgaaagcg cttataaaat aaatacttct
    20281 ttgtgcagaa agacacaaaa aaaacaattt gaaaattaat tttgaaaacc atttttatta
    20341 catcaggtga ctttaaattt tctataataa tgatgaacct agttagatca agcttttctt
    20401 gctatcagta tcttgatctc agtttttcaa cagttaccta aaaacaaaat aaaaggtaac
    20461 tgttgaaaaa ctttatgaaa cattgaaagc gctcttagaa agaacacaaa aaagccatct
    20521 caaaaaagat tggtagtata taataaactt actagttcct taaataggta aatgtgaaaa
    20581 agaggtagct catgcagttt ttacaaaaat ggtttaaaca ctctaaaaaa gagaagttga
    20641 aagaatcctc gccccttagt acagaaatag aaccttctga aaactgggaa aagattcccg
    20701 cttatattcc tgcagacaaa agtgattaca aaaaggttac tttaattacc agtgctattg
    20761 ctgctggcga tagacctaat agtcaattca aggttaaacg cattctcaag cgcaatcctg
    20821 aggcaatcac tgtttcttta attgcttcaa gtatcgctgc aggtgtttac ccagaaagtc
    20881 agtttcgggt gacatccatc tattgcaaaa ggtagtcggt gaacgatact ttagacgaac
    20941 tcatgacaca ataacatata ggagaaaaat gatgttacga aaatttaaaa ttaccattga
    21001 cggtaaagaa tatcttgtag aaatggaaga aatcggtgct cctgcccaag cagctgcccc
    21061 cgctcaacca atatccactc cagtacctgt ccctactgaa gcaagcccac aagtggagga
    21121 agcgcaagca ccacagccag tagctgcagc gggagcggat gccattccat caccaatgcc
    21181 tggaaccatc ttaaaagtct tagtagcagt gggagaccaa gtaactgaaa atcagccact
    21241 attgatttta gaagccatga agatggaaaa tgagattgtg gcctcatcag caggaaccat
    21301 tacagctatc cacgtcggtc aaggtcaagt ggtcaatcct ggtgatggtc tcattacaat
    21361 tggttaatag tactataact agaataaata gacagaaaag gaagtgaatt tgtggacact
    21421 ttaatcgcag gaataacctc catcaccatt cctcaaattg ttatgatggt catcggtgcc
    21481 ctcttaatgt atctaggaat taaaaaagaa tacgaaccaa ccttacttgt ccccatggga
    21541 cttggaacca ttctcgttaa cttccctggt tcaggagttt taacccaagt ggttaacgga
    21601 gtcgagcaag aaggggtttt tgaggctctc ttcaattttg ggattggaac agaacttttc
    21661 ccactgttga ttttcattgg tataggagcc atgattgact ttggtccctt gcttcaaaac
    21721 ccattcatgc tcttgtttgg tgctgcagct caattcggaa ttttctttgt tgtcgttgtt
    21781 gccgtactgg ctggctttga cattaaagaa gcagcttcaa tcggcattat cggagcagca
    21841 gacggaccga cttctatctt tgttgccaac caactggcca aggatttact gggtccaatt
    21901 acggttgcag cctattctta catggctctg gttcctatta tccaaccatt tgccattaaa
    21961 ttagtgacaa cgaaaaaaga gcgccgtatc cgtatgactt acaaagctga gaatgtatct
    22021 caaatgacta aaatcttatt cccaatcatc attaccttag tagcagggtt catcgcccca
    22081 atttctctac ctttagttgg ctttttgatg ttcggtaact tattacggga gtgtggtgtg
    22141 ctcgatcgcc tgtcacaaac tgctcaaaat gaattggtaa acattattag tatcttgctt
    22201 ggattgacca tctctattaa aatgcaggca gacctgttct taaatgtaca gacactctta
    22261 atcatcgtct ttggtttact tgcttttatc atggattcta tcggtggggt catgtttgcc
    22321 aaatttctca atctcttccg aaaagagaag attaatccaa tgattggcgc tgcgggtatt
    22381 tcagcttttc caatgtcaag tcgtgtcatt caaaaaatgg caacagatga agacccgcaa
    22441 aactttatcc tcatgtacgc tgtaggtgcc aatgtctctg gccaaatcgc ctctgttatc
    22501 gcaggtggtt tgttgctagc ttactttagc taagaaagga aggaaacctt atgacaatta
    22561 atatggacca tttgattagt tcctttgagc taatggcgct tggtatggca ggtgtcttta
    22621 tcgtgttagg cattctctat cttgtcgcag agatcctgat caaacttttc ccagttagta
    22681 aataacaata tcatttaaga aaatcaagga ggtaaacgca atggatatta aacaaactgc
    22741 cgttgctggt tcacttgaat caagtgacct aatgattaca gtatccccta atgacgagaa
    22801 aaccattaca ataaccctag acagtagtgt tgaaaaacaa tttggcaatc acattcgtca
    22861 actcattcat caaaccctag tgaatttgaa ggtgacggct gccaaagtag aggctgttga
    22921 taaaggcgct ttagattgca ccattcaagc gagaaccatc gcagctgttc atcgcgcagc
    22981 tggtgttgac caatacgatt ggaaggagat tgactcatgg aacgtttaag aagaacaatg
    23041 atgtttgtgc caggtgccaa tgctgctatg cttcgagatg ctcctttgtt tggtgctgat
    23101 tccgtcatgt ttgacttgga agattctgtt tcactcaaag aaaaagacac ttctagagct
    23161 ctcgtccatt ttgcgctaaa aacttttgat tattcgagcg ttgaaacggt tgttcgtgtg
    23221 aatggtcttg attcttgtgg ggctttagac atcgaagctg ttgttttggc aggtgtcaac
    23281 gtgattcgtc ttccaaaaac agagactgca caagatattg ttgatgtgga ggctgttatt
    23341 gaacgtgtcg aacgcgaaaa cggcattgaa gttggtcgca cacgcatgat ggcagccatt
    23401 gaatcagccg aaggtgttct aaatgctcgt gagattgcca aagcttctaa gcgcttgatt
    23461 ggtattgctc ttggggcaga agactatgtc acgaatatga aaacgcgtcg ttacccagat
    23521 ggtcaagaat tattctttgc tcgtagcatg attttacatg ctgctcgtgc tgctggaatt
    23581 gctgccattg atactgttta ttctgatgtc aataatacag aaggattcca aaacgaagtt
    23641 cgtatgatca aacagttagg atttgacggt aaatcggtca tcaaccctcg tcaaattcct
    23701 ctggtcaatg agatttatac cccaaccgaa aaagaaattg accatgccaa acaagtcatc
    23761 tgggcaattc gtgaagctga aagcaaaggc tctggcgtta tttccttaaa tggaaaaatg
    23821 gttgataaac caatcgttga acgtgcagaa cgtgtcattg ccctagcaac agcagcaggt
    23881 gttttatctg aggaggacat ttaaagatgg taacaaataa actcggtaga gatattcctc
    23941 aaccatacgc cgaccaatac ggtgtctttg aaggagaact cgcaaatatc aaacagtatg
    24001 acgaatcaag tcgccgtatt aaaccagtta agcctggaga ttctaaatta ctaggatctg
    24061 ttcgtgaagc gattgaaaaa acaggtttaa cagatggcat gaccatttct ttccaccacc
    24121 atttccgtga aggggatttc attatgaata tggtcttgga ggaaattgcc aaaatgggca
    24181 ttaaaaacct gtctattgcc ccaagttcca tcgctaatgt acatgagcct ttgattgatc
    24241 acatcaaaaa tggtgtggtc actaacatca cttcatctgg tcttcgtgac aaagtagggg
    24301 cagccatctc agaaggacta atggaaaatc ctgtggttat tcgctcccat ggtggtcgcg
    24361 ctcgtgccat tgctagtggg gatgtccata ttgatgttgc ctttctgggc gccccaagtt
    24421 cagatgctta cggaaatgtt aatgggacaa aagggaaagc aacctgtggt tctttgggct
    24481 atgccatgat tgatgccaaa tatgcggatc aggtggttat cttgacagat aatttggttc
    24541 cttatcctaa taccccaatc agcattcctc aaacagatgt tgactatgtg gtaacagtgg
    24601 atgctatcgg agatcctcaa ggaatcgcca aaggggcaac tcgttttacg aaaaatccta
    24661 aagaactctt aattgcagaa tacgcggcta aggtcatcac taattctcct tatttcaaag
    24721 aaggattctc tttccaaact ggaacaggtg gcgcttcttt ggcagtaacc cgtttcatgc
    24781 gtgaagctat gattaaagaa aatatcaaag ctagctttgc tcttggtggt attaccaatg
    24841 ctatgatgga gttgctcgaa gaaggactgg ttgaaaaaat tcttgatgtc caagactttg
    24901 atcacccatc agctgtttct cttggtaagc atgctgaaca ttatgaaatt gatgccaaca
    24961 tgtatgcctc acctttgagc aagggtgctg ttatcaatca attagacact tgtattttat
    25021 cagcccttga agttgatact aacttcaatg ttaatgtgat gacaggatct gacggcgtga
    25081 ttcgtggcgc ttctggagga cactgcgaca ctgcctttgc ggctaagatg agtttggtta
    25141 tttcaccact tatccgagga cgcatcccaa cttttgtaga tgaggttaat acggtcatta
    25201 caccaggaac aagtgtcgat gtggtcgtca cagaagtggg aattgccatt aacccaaatc
    25261 gtcaagactt agtagaccat ttcaaatccc tcaatgtgcc acaatttagt attgaggagc
    25321 taaaagagaa ggcttacgcc atcgttggca cacctgagcg tattcaatat ggtgataagg
    25381 ttgttgctct tattgaatac cgtgatggta gcctcatgga tgtggtttac aatgtgtaga
    25441 gacacttatt tttcaggcga agctatccaa cttagtgata tgttaagagc ccgcgaagaa
    25501 agagcactgc gtcagctgca tttattaaag gagtacccag aaggtagctt attatcggtc
    25561 accatgaata tccctggacc aattaaaacc tctcctaaac ttcttgaagc ttttgatata
    25621 gtgattaagg ccattcaaac tgccttagct gacgataaga tttgttacca gttgcgatta
    25681 ctgcctacaa cgggttatga gtattacctc atcacaagtc tacctagccg cgacctgaag
    25741 ttaaaaatga tagccttaga gacagagttg ccaataggtc gtctcatgga tttagatgtc
    25801 ttggtcttgc aaaatgatct gcctcattca attagcagaa ccgtattagg aggctcccct
    25861 aggcaatgtt ttatctgttc taaagaggcc aaagtctgcg gtcgcctacg taagcacagt
    25921 gtcgaggaga tgcagactgc tatttcaaaa ttactccatt catttttcaa taaagacaac
    25981 caatcatcgt catcagataa gacaggttga tgaggagaac aattatgacg aaaatccgta
    26041 taacggaaac agttttacgt gatggtcaac aaagtcagat tgccacacgt atgacaacca
    26101 aggaaatgat tcctattctc gaaacgctag acaatgctgg ttatcatgcc cttgaaatgt
    26161 ggggaggagc aacctttgat tcctgcctac gctttttaaa tgaagaccct tgggaacggc
    26221 taagagccat ccgtaaagca gtgaaaaaga ctaaacttca gatgctctta cgcggacaaa
    26281 accttcttgg atatcgcaat tatgctgacg atgtggtcag atcctttatt caaaaatcca
    26341 ttgaaaatgg gattgatatt gtccgtattt tcgatgcttt aaacgaccca cgcaacttgc
    26401 aaacagctgt ttcagcgact aaaaaatttg gagggcatgc tcaagttgcc atttcttaca
    26461 cgacaagtcc ggtacatacc attgactact ttgttgaatt ggcgaaagct taccaagcta
    26521 tcggagcgga ctccatttgt atcaaagaca tggctggtgt cttaactcct gaaataggtt
    26581 accaattggt caaatgtatc aaggagaata caactatccc tcttgaggtt catacccatg
    26641 ctaccagtgg tatttcagaa atgacttact taaaagtagc agaagcagga gctgatatta
    26701 ttgatacggc gatttcctct ttttcaggtg gaaccagtca gcctgccaca gagtcaatgg
    26761 cgattgcctt gacggattta ggctttgaca ctggcttgga tatgcaagag gtggccaaag
    26821 ttgcagaata tttcaacact attcgtgacc actatcgaga agtagggatt ttaaatccta
    26881 aagtcaaaga tactgagcca aaaacattga tttaccaagt tccaggtggc atgctatcaa
    26941 acctattgag ccaattagcc gagcaaggcc tagctgataa atacgaagaa gtcttagcag
    27001 aagtacctaa agtaagggct gatcttgggt atccgccact cgtaacgcca ttatcacaaa
    27061 tggttggcac acaggccttg atgaatatca tctcagggga acgctacaag gtagttccaa
    27121 atgaaattaa agactatgtt cgagggctat acggtcaatc accagcgcca ttagtagaag
    27181 gtatcaaaga gaaaatcatt ggtgacgaag cagtcattgc ttgcagacca gctgacttaa
    27241 tcgagcctca aatgatttat ctacgtgacg agattgctca atacgctcgt tcagaagaag
    27301 acgtgttaag ctatgcgagt ttcccacagc aagccagaga tttcttggga cgccgtgaag
    27361 atcctttcta tgatgttccg gttcaagaag ttactgtaca actggacatt caagactaac
    27421 agggaatgac taatcctctt aaccattaat ctccttggtg aaacgcattt gctgtaagaa
    27481 taataccaaa aacctacctg attttgataa tcagataggt tttttatctt agtaatgttt
    27541 gacagatgaa gtggcttgta tctttttaat aatgggttgg gcttctagcg aacaaaaata
    27601 atctaaagac gttttgggaa ggagttttgc cagaaggtcc caatcattat ctttcaatgc
    27661 ctgcctagcc gttgaggcac tgataggatc ttgctgctga ttgatagctt tccttggcaa
    27721 aatatctagg aggataccag cttgctgcaa ctgctctgcc ataatttcat tgtaaatagc
    27781 agttactcgg ctggttggct cttctccaac gtatcttttt gtaatctgta aggtttgagc
    27841 aatctttaga aaaatagcag tatccagcaa agcttggctc ttaatcacgt cattgtcttc
    27901 tttttggaaa taggctggga aagtcgcttg gctaatcaaa taaggacctg tttcatgata
    27961 tatgacatta tcaagatgag ctagaccttc ttgaatcaac ctctttctca ccgaaaaagg
    28021 aattagactg cggtcttcac tgaccattaa cagatgaacc caatcatttt ctcttgcagc
    28081 tttctctact aaaaattgat gccctaaggt aaaggggtta gcgttgataa cgacagcagc
    28141 gactttacca ggtgtttgct caggcttatt aagtgtcatc agataatctt gaaaaccagt
    28201 ttttttattt tccaagaaac tgatgtgatt gtcgatatgg acaatttcag taaaaccaag
    28261 atctttgaaa aaagcagcag aagaggtctt cgtataaaca aaaagatgat agttgccaag
    28321 ggtatattct tcatcaatga gatgactcac aatcctatta agaagtcctt caccttgata
    28381 ggcactggat acgcaaagac agcgcaagct atttccaaag taagaaccgg tagcaatcac
    28441 atcattttgc gcattcatga tggcacaagt ataatctaaa tgagcatcca aacgaatacc
    28501 ttcttgatga agtaggttct ttacactagc cattgtcgtt ttatctgaag gaaagacttt
    28561 tgaaatagtg tagtaaggca tttcttctcc ttatctttaa ttttattgaa tcataacata
    28621 acttagtacc aaaacaggct gatctatcta aaggcaactc tgttttttat caacgccatt
    28681 ttttaaaagg aaatcgaatg tgtttgacag actcaaaagt atcagcgatt ttttgattgc
    28741 gttccacagt ccgcaagttt tcttggtcta ataagtcttg acttttttcc aaaacatcaa
    28801 cagtaatgta gtagagtttg atcaggcttc ctatcttata tttaccagat tttggagaca
    28861 tagcaaccac ttcattgaga ttactatgaa gccatttttt atgaggctta gcaggtatag
    28921 tggctactac aaagccaagt tgttccaaat gagcttgtgc ctgatcaaca ggaagattaa
    28981 tcacatcatc tatcgtgcgt agttgcatct ctttttcatg tttttgttcc atacgttttt
    29041 cgataattgg tcgactgtta tcaatcgttt ttccaataat ttcagtagtg tcaggaacaa
    29101 ttgacatcag tttcccaact actcctagag cttttcttat tctctttggc atcttttatc
    29161 tcctcaagtc gtttcttttt attataacaa aatgtctaaa aatagtatgc gataaacctt
    29221 gttctaaaag gttaaataga tcaattcaag gaaaaaatag gaggcgatcc gacaaaaaaa
    29281 cacaaaaatt ctaaaaaagt caagctattt tagtttagcc tttgtcaatc gtatcagttc
    29341 aaatagaaaa tacaagtttt gacaagaatt tatttatgta acaaactgtg tttttgattc
    29401 ttcagtctat ctagcgataa tgttatctga ttcttgtttt caaccaattg atgttaaaga
    29461 agctgtcttc atgattctct aatattcctt caattttagc tttatattac tctaagttat
    29521 cagtaatgac attaagtagt ttaacaagaa taatcctaaa agctacttta caaaataacg
    29581 tattatcata ctaaataaaa gtactaacat actaaaaaca ggcttatctc atctttttga
    29641 tgagaaccct actagattta atctataaac atcacaaaaa agtcattcaa agaagggaca
    29701 aagttagcag taatattcct ttttctaagt ggcttgagta gtttggaaaa cggcctgaca
    29761 ccaaactgtc acggttaata gtagccatct attaaagtta attttgaagc tatttttatc
    29821 tttaatgtta cataaaaaca attatgtaac attaaaggtt atctaaagca tttttttgct
    29881 catcattgac aatatgggta taaagatccg tgacttgagt agaggaatgg cctaattgat
    29941 gactaactaa cacctgagat ttagtagcat catatagtct tgtcgctagc gtatgacgca
    30001 atttgtgagg agtcacacga attttaaaat cctcagagta cttgccaacc atcttttcta
    30061 tactagaagc atccattcga tttggaacgc cacggtattc tgttaaaaag aaagcaagat
    30121 cctgtttttc agccttgtaa cgtctctgac gaacagctag ataagactcc aaataacctt
    30181 tcgcaaaacc tgctacattg actgaatcac gttttccgcc tttgcgaata acttcgataa
    30241 tcatcatatt tagattgaca tcttttaaat caagattcac tgcttcagac aaacgaacac
    30301 cagaagcaag tagtagagca ataatagcca aatccctctc cttattttta cggaaagaag
    30361 atttggcacg attagacaat ttttgctcat attccttatc cacataatcc aagaaagcta
    30421 gagtttcatc acctaaaaac agtttctgct taatattttc cgctctggaa gccagggttt
    30481 cttttttctt ttttgttgac acttttttca taacattccg ataaaaataa ggctctcctt
    30541 ggtcattttc aacctcttca gtcaagtact tgtaaaggct tgatagggca gacaaggtcc
    30601 gattaatagt ggtttgagaa agcccctctt tggtggaata ggtgttgaga gaaggtcgtt
    30661 cccgcaaata aagcacaaag gcctctaaat ccttcttggt aaggtgctca agcgtgctca
    30721 agtcaatatc agcaatcttt ggcgcctgcg ttaaatcagc atccatcagc caatcaaaaa
    30781 agcgtttgta ttcttttaaa tactcatata aggtggtaaa gctgtatgga acagctaatt
    30841 tggattggta ataatctaaa acataccaag gcatgatagc cttgtaggtt tcaatttttt
    30901 ctagtaataa ttcgcgtctc atatcatcat aattccttaa caataacaat ttttcaaaaa
    30961 tgaattttcg caaattgtct catgtatttt atgccattca ttctctacaa gagcagtata
    31021 tcacacctat aaatattttt caagaaaatt acagtttttc ggaaagatgt tacgagacag
    31081 atctcttttt ttacagatac taacgtcact tcttttagat tcagtaataa tttactatca
    31141 ttattttagt aatttcaggc acagaatttg tttagctcag aactaaatga taattttatc
    31201 tttaaagcaa ttaactcttt atcagatata gacctgctag tacacgaatc tagtcgctat
    31261 gttatgtttt aggtgttccc cctttttgac agtgttacta tcatatgaat taattgtagg
    31321 aaatgttaca cttgctttcg ttttattttt ttgatactat tagtaaagtt ataactttac
    31381 taaaggagct accaaatgtt ttctggacat caactaaaaa cagcacgatt atcaaaggga
    31441 ataactcaat cagaattggg aagattgttg catgtcaata aaatgacaat atctaattgg
    31501 gaaaaaggta agaatatacc aaatgaaaaa catttaaatg ccttattgca tctattcaat
    31561 gtgacatctg attatttcga cccaaactat agattgctaa cgccttataa ccagctgaca
    31621 atatctaata aagaaaaagt aattggctat tcagagcgat tgttaaatca tcaaataaac
    31681 aaaaaatcta aagatctcat agataaacca tcacaattat atgcttatcg ggtctatgaa
    31741 agtttatctg ctggtactgg ttactcctat tttggtgatg gtaactttga tgttgtcttt
    31801 tacgatgaac aattagaata cgattttgcg tcttgggttt ttggagattc tatggagcca
    31861 acttatttaa atggtgaagt tgttcttata aaacaaaata gttttgatta cgatggagca
    31921 atttatgcag tcgaatggga tgggcaaaca tatatcaaaa aggtatttcg tgaagatgag
    31981 ggattacgtc tagtgtcctt aaataaaaaa tattctgata agtttgctcc ctatagcgag
    32041 gaacctcgca ttattggcaa aattatcgct aattttaggc ccttagaaat ttaagttaga
    32101 ttgataatga actcatcatg gtatgtaaca cggtcttccg taattttaat aatcttgtat
    32161 acaagataaa tgaatttcac atcaaaaaga gacgaaaatt ttcgtctctt ttattttcgt
    32221 tttttctttg ctttttttag tttgttagcc tgccgtttca tggcctgttt catggcaaat
    32281 tggccaattt ttcctttaaa ccctttacca aatagttgac tcatatccat atcaccatta
    32341 aggccagata aatcaggcat accaccttgt cccatcatcc cttctaagga agacatatct
    32401 ggcataccag caggcatgtt tttaggaaga ttattgggat taatacccat atctttcatc
    32461 attttagcca tatcgcccga cataacccct tgcatcatgc ttttggcttg gttaaagtct
    32521 ttgataaatt tattaacttc cacaaagctg ttcccggaac cagctgcaat acgacggcga
    32581 cgactcgggt ttagtaagtc aggattttca cgttcagcgg gtgtcattga agagacaata
    32641 gcacgtttgc gagcaatttg gttttcgtca aatttgatat tggccaaagc tgggttacca
    32701 gccattcctg gaatcatttt caagaggtct tccataggcc ccatattttg cacttgatct
    32761 aactgttcaa taaaatcatt gaaatcaaag gtgttctcac gcattttttc agctaactct
    32821 aaggattttt tctcatcata ttcctggcta gctttttcaa tgagggtaag caaatccccc
    32881 attcccaaaa tccgactgga catgcggtct gggtgaaatg tttcaatatc tgtgattttt
    32941 tcaccaatac ctgtaaattt aattggtttc ccagtgattt cacggacaga tagcgctgca
    33001 cctccacggg tatcaccatc aatctttgtt aacacaaccc ctgtgatgct caactgatga
    33061 ttaaactcgt aggctacatt ggcagcttct tgaccaatca tgctatctac aaccaaaaga
    33121 atttcatttg gttgtgctaa agccttgaca tcgcgcagct cttccatcag tttttcatca
    33181 atttgcaagc gacccgcagt atcaatcaag acatagtcat tgcggttttc acgagcttgt
    33241 tccaaacctt ttctgacaat atcgactgct gagtggtctg tccccatatc aaaaacaggt
    33301 acattgattt gttgccccaa tgtttttaac tgatcaatgg ccgctggacg gtaaatatcg
    33361 gcagcaatca tcagtggtcg cgcgttttct tctttaatta atttattagc gagttttcct
    33421 gcaaaagttg ttttaccagc cccttgcaaa ccgaccatca tgataatagt tggaattttg
    33481 ggagatttat caatctctgc agtttctgag cctaaaatac tcgttaattc ttcattaaca
    33541 atcttaagaa tttgttgtgt tggatcaaga gtatcaataa tctcatggcc aatagcgcgc
    33601 tcacgtacgc gtttaataaa ggttttaaca actggtaaag cgacatcggc ttctaaaaga
    33661 gctagacgaa tctcttttgt cacttcttga acatctgatt ctgataattt ctttttaccg
    33721 cgaatgtgtt taaacacatc ttgcaaacgt tgggttaagc tttcaaaagc catagtcaaa
    33781 actcctctta ctctctattg tcaatactgg ttagaatgga aattttttct tgcaaatact
    33841 catcatgagg gtagtgagca atcatgtcgt caaagatttc acttcgaaca acataatccg
    33901 aatacatatg aagtttcatc tcataagtct ctaaaatttt ttccgtacgc ttaatattat
    33961 catagacagc ctgacgactg acaccaaatt catcagcaat ctcagctaag ctataatcat
    34021 cggcataata cagttcaata taattcattt gtttatctgt tagcaaagct gcataaaatt
    34081 caaaaagggc attcatcctg tttgtttttt caatttccat aatgttcatt ttatcatact
    34141 atgattgttt ttaacagtag caaattaatt gccttgtgct gttcgtgtaa aaaaagaagt
    34201 cataaatgac ttctttacta attattttct aagtaaaatt caaaacggtc accgatatac
    34261 tgactgcgga catactcaaa aggtttgccg tctgtaaagt aagacacctg agttagagcc
    34321 aaaatggcat gtcctttagc aacttccaag taggaggcta cacgctcact tgctagctta
    34381 gcgtagattg tctgtttact tttaccaatc tcgtaaccat ttgctatcaa tgagtgaaaa
    34441 aagtgttctg taatatcagc tcgtttaacc gtttttataa atttttctgg gattgaagca
    34501 atttcgtaca ccaaagggac actgtctgca tagcggatac gttccattcg aatgaccaag
    34561 tctgttttgt ctaagttcaa ttctttaact tcggtatcac tagctaattg cttttgatag
    34621 gataataatt tagaggaggg ttgtcgtcct tgggagcgta taatttctgt gaaacttgtt
    34681 gttcctcgca ttttttcttg aacacgatga ctggcaacat aagtaccact tcctatccgc
    34741 ctttcaagaa tcccttcttc tactagtaat gtaatagcct gccgtagagt cattcgacta
    34801 acggtgaaat attccgctaa atgtcgttca cttggcaagc gactaccaat tggccagatg
    34861 cccagatcaa tgtctttttt aattgcatca tgaattttta tataagctgg taacatgcca
    34921 cactcctcaa gtcggttatt catctatttt atcatatttt tgatgaaaat tgaattgtaa
    34981 atattgaggt atttggcatc aattaatgat attacctgcg acaataaccg gtgaatttgg
    35041 tggaaaatga ataggttcca taaaccaact agtgagcttc gctttagtaa caatggatga
    35101 ggtaaaaaca ttatttaaaa ccctaataac tcctactttt gaggaatgct gaccaataga
    35161 accactatag gctctcaggc aaccagtcgg atctatataa ggtaaaaatt gattttggct
    35221 tacagtaata ttgtgacata gatgtcgagt ttggttaaat gcttcatagt ttggagcaat
    35281 attactaagt agacctccat cccatgcaaa atgatgaaca gcagcatcaa actgaatgac
    35341 ttctgaaaaa aaatcatgcc cttgagcctt tgatagcagc tgttggtctt gtactaattc
    35401 tggcgcatag ccaataaatt ggtttttctc aaacaatgaa ttttgtagag atcctaaatc
    35461 aaaaatatga ctattacgct tatgaaccat agtaaatttg ttatcgtaaa tatgccaatc
    35521 agtaccatga tcagccataa tcataaagtg gtctcctttt ttcaaatcat ttgctttgaa
    35581 atgcactcca gtcaacacga gattacgaac accttgttca gcctttggtc ctgtagggaa
    35641 tccaaaccac aacattttac cgtgaataat gaactctgtc tgatgaccaa taatagctgt
    35701 atcagatgga agctcaaaat aatctttttg tgaaggcaaa gagccaatgt gaaattgccc
    35761 ctttggaaaa gatataacgc tatttggatg ctgctttgca taagcgaaag cttttcgcaa
    35821 aagacgattg ttttgctcag gggaatttcc tttattgaac ctaatataat aaggtttaac
    35881 aaaatcttgc tctgaaattc catctaatct tagattatct ttcagattaa tatcgtactg
    35941 atatcctcct aacgaatagt catagcgttt tttaacttgt ttaatagtcg ctaattgacc
    36001 ttgatatact tttatatgtg gctttttagt taatgaagat aatttaacga tatctccttt
    36061 tttaaacctc ggtttatcgg gctctttcag gttatgttct ggcaaagaaa cagtgacttt
    36121 tcctattgga aataccactt cataatgata actcactcgg taattttcgg ctatatcttc
    36181 tacctgttta ttaatagttc caatccattg atgatatgga ccactttttt gtacttgaat
    36241 agcttgtcca atgtgatagc gaggctgttg atctttgctt cgttccacta ttccgacagt
    36301 tgctaatata ttgtgaagtg ttgcaaaact attggtccac gcaaggtacg agacaactaa
    36361 actcaacaat aatcctagga aaattaattc aacaggtcga aataaaccca aaattctctt
    36421 tttgcttagc ataggccctc cctgttgtct taattccctt tcatagcctc tattgtaaca
    36481 taacgattac gtttttttcc aacgagctag agaaattgta atgtcttttc gatgaaaata
    36541 tgctacaata agttgacaac tatcaacctg acggttggta tagaatgaaa ggattataat
    36601 gactgaaatt tcaattttga atgatgttca aaaaattatc gttcttgatt atggtagcca
    36661 gtacaatcag cttattgcta gacgtattcg agagtttggt gttttctccg aactaaaaag
    36721 ccataaaatc accgctcaag aacttcgtga gatcaatccc ataggtatcg ttttatcagg
    36781 agggcctaac tctgtttacg ctgataacgc ctttggcatt gaccctgaaa tctttgaact
    36841 agggattccg attcttggta tctgttacgg tatgcaatta atcacccata aattaggtgg
    36901 taaagttgtt cctgctggac aagctggtaa tcgtgaatac ggtcagtcaa cccttcatct
    36961 tcgtgaaacg tcaaaattat tttcaggcac acctcaagaa caactcgttt taatgagcca
    37021 tggtgatgct gttactgaaa ttccagaagg tttccacctt gttggagact caaatgactg
    37081 tccctatgca gctattgaaa atactgagaa aaacctttac ggtattcagt tccacccaga
    37141 agtaagacac tctgtttatg gaaatgacat tcttaaaaac tttgctatat caatttgtgg
    37201 cgcgcgtggt gattggtcaa tggataattt tattgacatg gaaattgcta aaattcgtga
    37261 aactgtaggc gatcgtaaag ttcttctagg tctttctggt ggagttgatt cttcagttgt
    37321 tggtgttcta cttcaaaaag ctatcggtga ccaattaact tgtattttcg ttgatcacgg
    37381 tcttcttcgt aaagacgagg gcgatcaagt tatgggaatg cttgggggca aatttggcct
    37441 aaatattatc cgtgtggatg cttcaaaacg tttcttagac cttcttgcag acgttgaaga
    37501 tcctgagaaa aaacgtaaaa ttattggtaa tgaatttgtc tatgtttttg atgatgaagc
    37561 cagcaaatta aaaggtgttg acttccttgc ccaaggaaca ctttatactg atatcattga
    37621 gtcaggaaca gaaactgctc aaaccatcaa atcacatcac aatgtgggtg gtctccccga
    37681 agacatgcag tttgaattga ttgagccctt aaacactctt ttcaaagatg aagttcgagc
    37741 gcttggaatc gctcttggaa tgcctgaaga aattgtttgg cgccaaccat ttccaggtcc
    37801 tggacttgct atccgtgtca tgggagcaat tactgaagaa aaacttgaaa ccgttcgcga
    37861 atcagacgct atccttcgtg aagaaattgc taaggctgga cttgatcgtg acgtgtggca
    37921 atactttaca gttaacacag gtgtccgttc tgtaggcgtc atgggagatg gtcgtactta
    37981 tgattatacc atcgccattc gtgctattac gtctattgat ggtatgacag ctgactttgc
    38041 tcaacttcct tgggatgtct tgaaaaaaat ctcaacacgt atcgtaaatg aagttgacca
    38101 cgttaaccgt atcgtctacg acatcacaag taaaccaccc gcaacagttg aatgggaata
    38161 acagaataaa cattaaaaga ctcgctcatt ttggcgagtc ttttaatgtt tattctttaa
    38221 ctgttttcgt attgtgtaca tggtattagc aatatgataa agtgggctga cagggagatt
    38281 aaattctcct ataaattctt ctattgtcgg agcaaagttg gccttaaatt tggtaagtcc
    38341 atcatcaagc gagccttcta ctcctcccat gttagcccaa ataataccat cttgataagc
    38401 atcctgaaaa actttaggat acagcagata ctgaggataa aacttcttaa aatcatcatt
    38461 catcccagca taaagcattt ccataacatt tccataagaa atagataata tacctgctac
    38521 aacaacttcc tcaggatatt ggtctgtaaa gccttcaaat tcagttatat aacgttctaa
    38581 agaagctttt tgatcttcta atttttttaa acgcttcttt tgatgagctt gggtgcgagt
    38641 aatatcttgg ttaataagaa ttaattgctg gcggtattga tctagttttt gaggaatatt
    38701 cacttttgct agatgtaagt aggccttatc cccataagta gtcatcaact tttgaaagta
    38761 agcttcgtta cgcaaagaaa tatttttacg tttttctgtt aaggagacaa tcttggaaaa
    38821 tttgtgaagt tctgattgac tggcacgata tgtttctaca ccacgctgct tagcatcttt
    38881 tattaaacgt ctggtatgct taggaaattg catctcaagg ttttcttgag tgtaaatatt
    38941 agcttggaaa cgaggttgga tactatctgc aatctccatt gttaaaccag tccaatgaac
    39001 accagcttct tggagattct taatagctgc taaagctaaa ggtttttctt cttcttcctg
    39061 tcccagtgcg tattgtttta acaggatagc tggatcatat ttgataaaga gggccttttt
    39121 agttttacca taatccttta gtgttttcat ggtaaatgcc accaaatcac ggtcaaggta
    39181 atccatgact ggccctcttg gaatataaat aatgcttctt ccaagtggca atagcttaat
    39241 caaaagtgat aaagaggcaa cctgcttttc ctctttatag ataccaattc gctcattctg
    39301 ccattgattt ttgattttcg cccaatcact accttgtaaa acgctaattt gctgatgttc
    39361 tttaacaaaa gagtcatgct cttcttctga aataccgatt tttgcataaa acgttaaatt
    39421 cgtcatatat tgtccccatc tattcgtaat cttagcagat gtacttacta agtatcttca
    39481 ctgtctttat ctatttattc gtaataaatt ttaaaaaaac ataaaaatag ggaaactatt
    39541 tgaatcactt tttagtaata acgtttgtat cttaaatgac ttgttaatca ccaacaattt
    39601 catgaacaac tgatcatcaa aaaataagct attattaaac gactttacaa cattccatta
    39661 gataaaaaaa gatgtagtca catctttttt tggttggtga tcagttacct aaaccatcac
    39721 atatctagca gtatttattc tatatcttta ctgattttag taatttctgt gtaaaaaatt
    39781 aaggaatagt ttaggttaac ttactaaaat cccaagtatc ggttacccac ccattgtaga
    39841 aatcaggttc atgacaaacc attaaaatag aacccttata tgcttttaaa gcacgtttga
    39901 gctcattttt agcatcaata tcaagatgat ttgttggttc gtctaaaata agcacgttat
    39961 tttcacgatt catcaacaaa caaaaacgaa cttttgcttg ttcaccaccc gaaagtactt
    40021 gaatttgact ttcgatatgt tttgatgtta gtccgcaacg agctagtgcc gctcgaactt
    40081 ctgcctgatt taaggcagga aaagcatccc aaactacttc tagcggagtt tgtcggttaa
    40141 cacctgtcac ttcttgttca aagtagccaa cttctaaaaa atcccctgtg acaatatgac
    40201 cttctaaagg ctcaataaca cctaataaac tttttagcaa agtagatttt ccaataccgt
    40261 tggccccaac aatagcaatt ttttgatttc tttcaaacgt tatatttaag ggttctttgg
    40321 tcaatgggta atcataacca atcacaagat tttttgtttg aaaaatgaat cgactgggag
    40381 ttctagcttg cttaaattca aaatttggtt ttggtttctc agcttgaagt tcaattatat
    40441 ccatcttatc aagttttttt tggcgagaca ttgccatgtt acgtgtcgct acccgagcct
    40501 tatttcggtt gacaaaatcc tgcaagttag caatctcttt ttgttgacgt tcataggctg
    40561 cttcaagttg agattgtttc atctcataaa cagcttgaaa ttggtagtaa tccccagtat
    40621 agcgaactaa actttgattt tcaacatgat aaacaatatt aatcacatca tttaagaaag
    40681 aaatatcatg cgaaatcaac acaaaagcat tttcataatg ttgtaaatag cgttttaacc
    40741 attcaatatg ctcagcatcc aaatggttag ttggttcatc taatagcaga atatcaggtt
    40801 tttctaatag taatttggct aataaaacct ttgttcgttg cccacctgat aaggatgtaa
    40861 catctgactc cattccaaaa tccataacac caagcgcacg cgctacttca tcaatcttag
    40921 catccaaagt atagaaatca cgactttcta aacgatcttg aagctcacct acttcttcca
    40981 tcaaaacagc aatatcagct ttatcatctg ccattgacgc gtaaatctca ttaatacgat
    41041 tctcggtctt aaataactca tcaaaagcag ttcgcaagac atcacgaacg gtttgtcctg
    41101 attccaacac tgtatgttga tccaggtaac ctgcagtgac atacttcgac cactctactt
    41161 ttccttcgtc aggctgtaaa tgtcctgtga ctatactcat aaaggttgat tttccttcac
    41221 catttgcccc aactagtcca atatgttcac cttttaagag gcgaaatgac acattttcaa
    41281 aaatagcccg atccccaaaa ccgtgactca actgcttaac ttctaaaata ctcatcgttt
    41341 cttccttaac tgtcatcaaa aaagccgtca aaacggcttt atagttattt cattatggca
    41401 aaattgtaac cttttgtcaa tatttgacta aaagtgtacc ttgctttttt atcgataagg
    41461 tacttgtatc aaaaacctct ttttgcttgt ccgattgtaa ccttttcttt taagtttttg
    41521 ataacaggat acaaaagagg aacagcaact aaagtcacaa aagatgttcc gaaactacca
    41581 ccaatttttc caagagctac ccaaaaagat accgaaagtg gtagctgagt acctatataa
    41641 gctaacagta agtattttat aaggttaata gttaattttg acaatgcagc aataactgtt
    41701 attgttataa tggcttttgg ttttttacta gattgcatag ctctttcata taccaaatgc
    41761 aaaattaaac aaatagccaa ggattctaag atagttatcc aaacgactga agcatagccg
    41821 ttcaaaacat caaagatccc taaaccaaga ctagcaacta gagctccttt tttactacca
    41881 tagattaaga ctgcaataac aactaatgca ttgccaagat gaataaactg cataccgaca
    41941 gggacacgca acacttgtac tgaaataaaa attaaagcgg catacatact caattcaata
    42001 taattagcta atttttgaga tgacattttt ttcctccaac aactttttaa acgatttagt
    42061 taagtaattt aaatgagatt cataagcaac acctaagatt aaatctcttt ttaatgtaag
    42121 ggtattttgc aatacttttt caagaaatga aacaacaaga tctagaattt gtgttagtgg
    42181 tagctgataa tagaatcctg ctgttataat agctgatgct atatctcctg taccatagaa
    42241 atggtaaggg aattgcttcc caaaatggaa tgttaattga tctgaatctg actgatagta
    42301 agcaaaacca atgctgccct cctcaaaaga gattccgcta atgacaacct gtttaggtcc
    42361 aagcttagct aattttctag ccacctgtct aatatcttct tcatcataat tttttgctaa
    42421 ataagctgtt tgtgttaata gacaagcctc actaatatta ggtaaaacaa gctcagcttt
    42481 ttgagtaagt tttatcataa tctctatatg tttttgactg aagccttgat aaagttttcc
    42541 attatctgcc ataattggat ctaaaattaa gggaagttgc tttcttgaaa gccattctag
    42601 cagcttttgc ccatctcttg ttgtcgtaaa ataacctata aaaatgccgt caaacttaat
    42661 tcttttgttg tcccaatctg ttaaaaaaac gtctaatata cttgatgtag tatgcttcac
    42721 agggctctgt cctccgccag tatggcttga taaaaggcaa gttggtaata aaacttgctc
    42781 taacaaacaa gaagccatta aaggaatact agcagacaaa gctaccttac caacaccaac
    42841 cagatcattt gccacaataa tccgtttcat agctattacc tcttttctat aataactatt
    42901 gtaagaaaaa gaggcataag atacaatagt tataacactt aactgtatgg ggacaattta
    42961 tgacaacaaa atatcaaaca atcatttcca atatcgaaca agatatccag aaacagcgac
    43021 taaaaaaagg ggacaagcta ccttcaatta gggtattaag taaggtttat cattgtagca
    43081 aagatactgt tcagcgggct cttttagaat taaaatatcg tcacttaatt tatgctgttc
    43141 ctaaaagtgg ttattatgtt ttgggtaacg taagcatgcc cgataatgtt cttaatctaa
    43201 gtcttgaaga ttataataat atggcttatg aagatttccg actctgctta aatgaggctt
    43261 taagtgctaa agacaaatac ctctttcatt attatcacaa aaccgaagga ctagaagaac
    43321 taagggaagc tttgcttctt tacttagctg aaaatagtgt ttacagtaac aaagaccaac
    43381 tattaatcac ctctgggacg cagcaagcgc tttatatttt atcacaaatg ccttttccta
    43441 atgcgggcaa aacaattctc cttgaaaagc ctacttatca tcggatggaa gctattgttg
    43501 ctcagttagg attaccctat caaactatct ctagacactt taatggcctt gatttagaac
    43561 tcttagaatc tttatttcaa actggtgata ttaaattttt ttacacgatt tcacgatttt
    43621 cacatcctct gggactttct tatagcacta aggaaaagga agctattgtt cgtctagcac
    43681 aacgatacca ggtttatatt ttagaagatg attatttagg agattttgtg aaacttaaag
    43741 agccaccaat tcattattat gacactcatc accgaatcat ctacctaaaa tctttttcaa
    43801 tgagtgtttt tcctgcactc cgtatcggag ctctagtttt accgtcaggt ttaaaacctc
    43861 attttttaac ccaaaaatca ctgattgatt tagacacgaa cttactaatg caaaaagtat
    43921 tagctcttta tttagaaaat gggatgtttc aaaaaaatct tcgctttatt aagcgttatc
    43981 taaaacagcg ggaacgtcaa ttggctctct ttttaaaaca aaattgccct gatattcact
    44041 atcaactaac ccctactcat ttagtgattg attacacgac atcagactct tatagaaact
    44101 ttacattaga taaatctgat agaataataa taactggaaa aaaacgctat ctctctattg
    44161 ctatcaatca acaaatacaa agcaaattaa actcactaat caaaaatact tg
//
LOCUS       DAUDWO010000013        44155 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.013, whole genome shotgun sequence.
ACCESSION   DAUDWO010000013 DAUDWO010000000
VERSION     DAUDWO010000013.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 44155)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44155)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44155
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.013"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(275..3814)
                     /gene="smc"
                     /locus_tag="VHC05_000655"
     CDS             complement(275..3814)
                     /gene="smc"
                     /locus_tag="VHC05_000655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HEQ5401985.1"
                     /translation="MFLKEIELEGFKSFADKTKIEFDKGVTAVVGPNGSGKSNITESL
                     RWALGESSAKNLRGGKMPDVIFAGTQNRNPLNYAKVAVVLDNSDHFIKTAKKEIRVER
                     HIYRNGDSDYLIDGRKVRLRDIHDLFMDTGLGRDSFSIISQGRVEEIFNSKPEERRAI
                     FEEAAGVLKYKTRKKETQIKLNQTQDNLDRLEDIIYELDTQLAPLEKQAKVAKQFLEL
                     DANRKQLQLDILVKDIDIAQERQTKDTEALAALQQDLASYYAKRQSMEEDYQKFKQKK
                     QVLSQESDQTQTTLLELTKLIADLEKQIELVKLESGQEAEKKAEAKKHLEQLQEQLDG
                     FQAEEKQRTEQLLHIDQQLCDVKQQLNELSNALERFSSDPDQLMETLREEFVLLMQKE
                     AALSNQLTALKAHLDKEKQARQHKAQEYQLLVTKLDQLNDESQKAQAHYKAQKEQVEM
                     LLQNYQEGDKRVQELERDYQLNQERLFDLLDQKKGKEARKASLESIQKSHSQFYAGVR
                     AVLQSQKKLGGIIGAVSEHLSFDSDYQTALEIALGANSQHIIVTDEAAAKRAIAYLKK
                     NRQGRATFLPLTTIKARSLSEHYHRQLATCEGYLGTAESLVRYDDSLSAIIQNLLSST
                     AIFETIDQANIAARLLGYKVRIVTLDGTELRPGGSFSGGANRQSNTTFIKPELEQISE
                     ELTRLVEQLKITEKEVAALQSDLIAKKEELTQLKLAGDQARLAEQRAQMAYQQLQEKQ
                     EDSKTLLAALDQSQTTHSDESLLAEQARIEEALTAIAKKKNVLTCDIDDIKENKDLIR
                     QKTQNIHQALSQARLQERDLLNEKKFEQANQSRLRTQLKQCQQNILKLESILNNNVSQ
                     DSIQRLPQWQKQLQDATEHKSGAQKRLVQLRFEIEDYEARLEETAEKIAKESEKNDIF
                     IRRQTKLETHLEQVANRLRAYAKSLSEDFQMTLADAKEVTNSIDHLESAKEKLHHLQK
                     TIRALGPINSDAITQYEEVHERLTFLTSQKTDLTKAKNLLLETINSMDSEVKARFKVT
                     FEAIQKSFKETFTQMFGGGSADLVLTETDLLSAGIEISVQPPGKKIQSLNLMSGGEKA
                     LSALALLFAIIRVKTIPFVILDEVEAALDEANVKRFGDFLNRFDKDSQFIVVTHRKGT
                     MAAADSIYGITMQESGVSKIVSVKLKEAQEMTN"
     gene            complement(3815..4507)
                     /locus_tag="VHC05_000656"
     CDS             complement(3815..4507)
                     /locus_tag="VHC05_000656"
                     /EC_number="3.1.26.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease III"
                     /protein_id="HEQ5401986.1"
                     /translation="MKQLEELLSTSFDIQFNDLTLLETAFTHTSYANEHRLLNVSHNE
                     RLEFLGDAVLQLIISEYLFAKYPKKTEGDMSKLRSMIVREESLAGFSRFCSFDAYIKL
                     GKGEEKSGGRRRDTILGDLFEAFLGALLLDKGIDAVRRFLKQVMIPQVEKGNFERVKD
                     YKTCLQEFLQTKGDVAIDYQVISEKGPAHAKQFEVSIVVNGAVLSKGLGKSKKLAEQD
                     AAKNALAQLSEV"
     gene            complement(4950..5759)
                     /locus_tag="VHC05_000657"
     CDS             complement(4950..5759)
                     /locus_tag="VHC05_000657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEQ5401987.1"
                     /translation="MNESGFKYSILASGSTGNCFYLETPKKRLLIDAGLTGKKITSLL
                     AEIDRKPEDLDAILITHEHSDHIKGVGVMARKYHLDIYANEKTWQLMDECNMLGKLDA
                     SQKHIFQRDKVLTFGDVDIESFGVSHDAIDPQFYRIMKDNKSFVMLTDTGYVSDRMTG
                     IIENADGYLIESNHDIEILRSGSYPWSLKQRILSDLGHLSNEDGAGAMIRSLGYNTKK
                     IYLGHLSKENNIKELAHMTMVNQLAMADLAVGTDFTVHDTSPDTACPLTDI"
     gene            complement(5763..7115)
                     /gene="vicK"
                     /locus_tag="VHC05_000658"
     CDS             complement(5763..7115)
                     /gene="vicK"
                     /locus_tag="VHC05_000658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall metabolism sensor histidine kinase
                     VicK"
                     /protein_id="HEQ5401988.1"
                     /translation="MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMM
                     SHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSDVFRLTHENLAQEKNRLASILAY
                     MSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
                     VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSH
                     ELRTPLTSVKSYLEALDEGALKEDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVT
                     QLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITSVWLEIDNDKMTQVI
                     ENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKAR
                     SRAQGGTGLGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD
                     "
     gene            complement(7108..7818)
                     /locus_tag="VHC05_000659"
     CDS             complement(7108..7818)
                     /locus_tag="VHC05_000659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019321978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5401989.1"
                     /translation="MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEE
                     KPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSAKDSEFDKVIGLEIGADDYVTKP
                     FSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
                     LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSR
                     PEYILTRRGVGYYMKSYD"
     gene            complement(7980..9014)
                     /locus_tag="VHC05_000660"
     CDS             complement(7980..9014)
                     /locus_tag="VHC05_000660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3114 domain-containing protein"
                     /protein_id="HEQ5401990.1"
                     /translation="MCYNMVKKDEEKAMKQAILDRYQALKCYQNAGLSNQAFRAIAKE
                     PIIDNRLGSPTFWVIWPIEKENQSAKQLLTFLLDLVEMPFELSGQLHETQTLLTRFHP
                     SLLPDHIFWKELASLVDQAFPGKTLSQAGDLEKRLHQFRYVISSQQAQSIRNHYKMIE
                     MTDAQALALFLRSKKGPCLWRQAPDYTLMDSARLHNKLRFEDNKVIFPSQEVSYNIKV
                     LLWFHTEFILDSTGFFLNEVDAEIVTEKGIVNGASFNYGTDGPRHWDLDVDPISRHDP
                     QFRRDTLKGFRTPKRVFRQWFRAQKDDFMFSYFNAKGLFAYHNKSSFARVKKSAKQFK
                     RQIHPIKGWF"
     gene            complement(9070..10317)
                     /locus_tag="VHC05_000661"
     CDS             complement(9070..10317)
                     /locus_tag="VHC05_000661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AMP-binding protein"
                     /protein_id="HEQ5401991.1"
                     /translation="MLTKLEYWAKQCPNKKAIVADQISLTYQELWQAVLIKDQTIKDS
                     VPYIISHSRYLNQLLSFLRGLKEGSCPIILHPNISGTFQQQIKHVDSELLKKADFAVL
                     SSGTTGKAKLFWRCLSTWTRLFDYQNKVFGMTGNSCLFLHGSFSFTGNLNLALAQLWA
                     GGCLVLSQKLSLKTWLSLWQAKKVSHLYLLPTYLNRLLPYLTKNNMTATHLLTSSQMI
                     SQELLRHYYKKFPQLEIVIFYGASELSFITWCNGRAAVKINGLVGQPFPDVSISFKDK
                     EIFVETPYSVEGMSQPYSVSDLGKMSPAGLILEGRQDDWVNQRGVKCHLPSLVELAHQ
                     APNVKEAHALKIGKGENETLILVLVLTKKDCLAPIKDFLALYLNSGQLPKYYLVIDCL
                     PLKDNGKINQEVLLNKIPKQWLS"
     gene            complement(10335..11423)
                     /locus_tag="VHC05_000662"
     CDS             complement(10335..11423)
                     /locus_tag="VHC05_000662"
                     /EC_number="2.3.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA C-acyltransferase"
                     /protein_id="HEQ5401992.1"
                     /translation="MTDVYIAAGLRTPIGLVGKQFAKEQPEILGAKLINALQNKYPVP
                     IDQVICGNAVGTGGNIGRLMTLYSHLGESVSALTVDMQCASAGAAFALGYAKIKAGMA
                     SNLLVGGIESSSLQPESVYASADWRQGPYKVAQFSPDTNSPFAMVEGAERVAREHGFT
                     KEYLNHWTLKSHQKASYCQEQTLLVDLILDLPGASDQGIRPRLSSKVLSKVPPILGEG
                     HVISAANACLTHDAAAFLQLSSQPSAFKLIDVVEVAGDPQRSPLMVIKASQVLLEKHG
                     LGMADMTAIEWNEAFAVIDGLFETHYPDLLDRYNIFGGALAYGHPYGASAAIIILHLM
                     RALEIKNGRYGIAAIAAAGGQGFAVLLK"
     gene            complement(11392..11961)
                     /locus_tag="VHC05_000663"
     CDS             complement(11392..11961)
                     /locus_tag="VHC05_000663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5401993.1"
                     /translation="MRRLLSTMIKCNQDLPKNSLVVDMTLEKAVQLYENQVLTDTQRF
                     RKIRLSESGLTLEVRFLKKQPVQWLSESTNSNQLEEKANKFLANDDQTINISQAALAH
                     FLEDTGDQKPIHREVPYVLPGAFLLEQVSDKLAIDYRQLHLRFYAPVVLDSSIQLMMK
                     GRAIGLFQAGKLVAKGDYDHDGCLYCCRP"
     gene            complement(12096..12806)
                     /locus_tag="VHC05_000664"
     CDS             complement(12096..12806)
                     /locus_tag="VHC05_000664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin family protein"
                     /protein_id="HEQ5401994.1"
                     /translation="MNFIGELLGTFILVLLGDGVVSACILNKTKAQNSGWIAIVLGWG
                     IAVTVAVYISGFMSGAHLNPAVTLAMAAIGSLPWSQVVTYLVAQFLGAMLGALVLYLH
                     YYPHWKETKDAGTILACFSTGPAIRHAWSNLLGEALGTAVLVITVMAIGPNKVAAGFG
                     PIIVGFVVMAVGFSLGATTGYAINPARDLGPRIMHALLPIPNKGDSDWSYAWIPVLGP
                     ILGGVVGALIYQVILNMM"
     gene            complement(12824..13198)
                     /locus_tag="VHC05_000665"
     CDS             complement(12824..13198)
                     /locus_tag="VHC05_000665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002960428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS-dependent dihydroxyacetone kinase
                     phosphotransferase subunit DhaM"
                     /protein_id="HEQ5401995.1"
                     /translation="MSNLGIIIVSHSKNIAQGVVDLISEVATDVAITYVGGTEDGGIG
                     TSFDQVQAIVDANPKDDLLAFFDLGSARMNIEMVSDFSDKIITLNVVPIVEGAYTAAA
                     LIQAGADKDAILSQLEELAINK"
     gene            complement(13198..13773)
                     /gene="dhaL"
                     /locus_tag="VHC05_000666"
     CDS             complement(13198..13773)
                     /gene="dhaL"
                     /locus_tag="VHC05_000666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxyacetone kinase subunit L"
                     /protein_id="HEQ5401996.1"
                     /translation="MQAQDAIKWMTLFNDKIQVNKDYLSQLDTPIGDGDHGGNMARGM
                     SAVMENLDGKEFASAADVFKVVAMQLLGKVGGASGPLYGSAFMGLSKASEDSSLADAL
                     QAGLDMIQKRGKAEKGEKTMVDVWIPVIEALKNDGLTKDVVEEAVLATKDIQATKGRA
                     SYVGERSVGHIDPGSFSSGLLFEAMLEAEVV"
     gene            complement(13784..14773)
                     /gene="dhaK"
                     /locus_tag="VHC05_000667"
     CDS             complement(13784..14773)
                     /gene="dhaK"
                     /locus_tag="VHC05_000667"
                     /EC_number="2.7.1.121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxyacetone kinase subunit DhaK"
                     /protein_id="HEQ5401997.1"
                     /translation="MKKIMNDATQIVDDMLQGLAYMHDDLVERLDGYDVIVRKAEKTG
                     KVALISGGGSGHEPSHAGFVGEGMLSAAICGAVFTSPTPDQILEAIKAADEGAGVFMV
                     IKNYSGDIMNFEMAQELAEMEGIDVASVVVDDDIAVENSLYTQGRRGVAGTILVHKIL
                     GHAAREGKSLADIKALADELVLNIKTIGLALSGATVPEVGKPGFVLEDDEFEYGVGIH
                     GEPGYKKEKLQSSSVLAQELVTKLADSFDMSAGQHYGVLVNGLGATPLMEQYVFANDV
                     AKLLAEKDVTVSFKKIGDYMTSIDMAGLSLTLIKLDKDEWTEALQSDVITPAW"
     gene            14925..15461
                     /gene="dhaS"
                     /locus_tag="VHC05_000668"
     CDS             14925..15461
                     /gene="dhaS"
                     /locus_tag="VHC05_000668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxyacetone kinase transcriptional
                     activator DhaS"
                     /protein_id="HEQ5401998.1"
                     /translation="MATSLITKKKIAKAFKKQLAVKSFDKISVVDIMDQAQIRRQTFY
                     NHFLDKYELLDWIFETELQEQVTHNLNYISGFQLLDELLFYFERNKTFYAQLFDIKGQ
                     NDFYSYFVDYCQVLMAKIISEYQSQEMSQSDAADYLAFLTHYHARALADMIKGYVSQS
                     EPKPCLTYLKQLILTSIH"
     gene            15476..16465
                     /gene="dhaQ"
                     /locus_tag="VHC05_000669"
     CDS             15476..16465
                     /gene="dhaQ"
                     /locus_tag="VHC05_000669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DhaKLM operon coactivator DhaQ"
                     /protein_id="HEQ5401999.1"
                     /translation="MVTILNQTQTLISQYIASVLAAHPHLAQLQDLPIIYNRHLDDQL
                     IPILSGGGSGHEPAHSGFVGDGMLSAAIYGDIFTPPTATDILEALRFLDKGKGVFVII
                     KNFEADIREFSQAIHLARQEGRNIKYIISHDDISVEPKKQFQMRHRGLAGTILLHKIL
                     GAAAQSGASLDDLEHLAFDLATEIATIGFATKSASLPNAALPLFDLPDHQISYGIGIH
                     GEEGYRTVPFMSSEHLAVEIVNKLQIKFHWQEDEHFILLVNNLGTATDLEQGIFLNDI
                     HQLLDLEGLHLPFIKNGKFMTSLDMTGISVTLCRLKDRQWLDYLQAPTNAYAW"
     gene            complement(16569..17354)
                     /locus_tag="VHC05_000670"
     CDS             complement(16569..17354)
                     /locus_tag="VHC05_000670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402000.1"
                     /translation="MAKLRRMHAIFIKQYLKQIMEYKVDFVVGVLGVFLTQGLNLLFL
                     SVLFQHIPSLEGWTFEQIAFIYGFSLIPKGIDHLFFDNLWALGQRLVRKGEFDKYLTR
                     PISPLFHVLVETFQVDALGELLVGVILLVTTAGSIVWTLPKVLLFILVIPFATLIYTS
                     LKIATASISFWTKQSGAVIYIFYMFNDFSKYPMSIYHSFLRWLISFVIPFAFTAYYPA
                     SYFLTGQHLLFNIGGLVVVSLLVLALSLKLWKWGLGAYESAGS"
     gene            complement(17356..18174)
                     /locus_tag="VHC05_000671"
     CDS             complement(17356..18174)
                     /locus_tag="VHC05_000671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HEQ5402001.1"
                     /translation="MQSFWKRYKPFISAGIQELMTYRVNFFLYRLGDVMGAFVAFYLW
                     KAVFDSSKQSLINGFTLSDMTFYIIMSFVTALLTKSDSSFMIGEEVKDGSIIMRLLRP
                     VHFAASYLFMEIGFRWIVLISVGFPFLVVIFGIKLMAGMSFWQLLATVFLYLLSLLLA
                     FLINFYFNICFGFSAFVFKNLWGSNLLKNALVAFMSGSLIPLAFFPKVVSIVLSFLPF
                     SSLVYTPVMIVIGKYSLSQIMVALSLQIFWLLVMVVLSQVIWKKVQYHLTIQGG"
     gene            complement(18176..19168)
                     /locus_tag="VHC05_000672"
     CDS             complement(18176..19168)
                     /locus_tag="VHC05_000672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEQ5402002.1"
                     /translation="MVMIEVSHLQKNFSKTIKEPGLKGALKSFVHPQREIFEAVKDLS
                     FEVPKGQILGFIGANGAGKSTTIKMLTGILKPTSGYCRINGKIPQDNRQDYVKDIGVV
                     FGQRTQLWWDLALQETYAVLKEIYDVPEKDFRKRMDFLNEVLELNEFIKDPVRTLSLG
                     QRMRADIAASLLHNPKVLFLDEPTIGLDVSVKDNIRRAITQINQEEETTILLTTHDLS
                     DIEQLCDRIIMIDKGQEIFDGTVTQLKQTFGKMKSLSFELEAGQEEVVSQFLGLPDIT
                     VERHELTLEIQYDSSRYQTADVIQRTMADFVVRDLKMTDADIEDIIRRFYRKEL"
     gene            complement(19309..21252)
                     /gene="thrS"
                     /locus_tag="VHC05_000673"
     CDS             complement(19309..21252)
                     /gene="thrS"
                     /locus_tag="VHC05_000673"
                     /EC_number="6.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine--tRNA ligase"
                     /protein_id="HEQ5402003.1"
                     /translation="MIKITFPDGAVREFESGVTTFDIAESISKSLAKKALAGKFNDQL
                     IDTTRAIEEDGSIEIVTPDHKDAYEVLRHSAAHLFAQAAKRLFPNLHLGVGPAIAEGF
                     YYDTDNAEGQISNEDLPRIEAEMQKIVTENYPCIREEVTKEEALELFKDDPYKVELIN
                     EHAGAGLTVYRQGEFVDLCRGPHVPSTGRIQVFHLLNVAGAYWRGNSDNNMMQRIYGT
                     AWFDKKDLKAYLTRLEEAKERDHRKLGKELDLFMISQEVGQGLPFWLPDGATIRRTLE
                     RYITDKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPVMDMGDGEEFVLRPMNC
                     PHHIQVYKNHVRSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHIFVTPEQ
                     IQEEFRRALQLIIDVYADFNLTDYRFRLSYRDPNDTHKYYDNDEMWENAQSMLKAALD
                     EMGVDYFEAEGEAAFYGPKLDIQVKTALGNEETLSTIQLDFLLPERFDLKYIGADGEE
                     HRPVMIHRGVISTMERFTAILIETYKGAFPTWLAPHQVTVIPISNEAHIDYAWEVAKT
                     LRDRGVRADVDDRNEKMQYKIRASQTSKIPYQLIVGDKEMEDKSVNVRRYGSKATHTE
                     SVEEFVENILADIARKSRPDAQA"
     gene            complement(21674..23008)
                     /locus_tag="VHC05_000674"
     CDS             complement(21674..23008)
                     /locus_tag="VHC05_000674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HEQ5402004.1"
                     /translation="MRVGLFTDTYFPQVSGVATSIRTLKEELEKEGHEIYIFTTTDRD
                     VKRFEDPTIIRLPSVPFVSFTDRRVVYRGLISSYKIAKHYNLDIIHTQTEFSLGLLGK
                     MIGKALRIPVVHTYHTQYEDYVSYIANGKIIRPSMVKPLLRGYLKDLDGVICPSRIVL
                     NLLEGYEVTIPKRVIPTGIPLEKYIRDDITAEEVTNLKAELGIAGDETMLLSLSRISY
                     EKNIQAIINQMPAILAENAKIKLIIVGDGPYLQDLKHLAMQLEVDKHVTFTGMVPHDK
                     VALYYKACDFFISASTSETQGLTYIESLASGTPIIAHGNPYLDDVVTDKMFGTLYYAE
                     TDLTDAIIDAILKTPVMDKRLLAKKRYEISAQHFGKSIYTFYLDTLIARNSKEAQKLS
                     LYLNHSGKSSSLKLVQGAIHLPKRAAKVTAITSVKVVKAPIKLVHAIKDFLD"
     gene            complement(23010..24008)
                     /locus_tag="VHC05_000675"
     CDS             complement(23010..24008)
                     /locus_tag="VHC05_000675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HEQ5402005.1"
                     /translation="MKVLLYLEAENYLRKSGIGRAIKHQAKALSLVGQHFTTNPRETY
                     DLVHLNTYGLKSWLLMIKAQKAGKKVIMHGHSTEEDFRNSFIFSNLLSPWFKKYLCHF
                     YNKADAIITPTLYSKSLIESYGVKSPIFAVSNGIDLEQYGADPKKEAAFRRYFDIKEG
                     EKVVMGAGLFFLRKGIDDFVKVAQAMPDVRFIWFGETNKWVIPAQVRQMVNGNHPKNL
                     IFPGYIKGDVYEGAMTGADAFFFPSREETEGIVVLEALASRQHLVLRDIPVYYGWVDQ
                     SSAELATDIPGFIEALKKVFSGASNKVEAGYKVAQSRRLETVGHALVDVYKKVMEL"
     gene            complement(24139..25140)
                     /gene="ccpA"
                     /locus_tag="VHC05_000676"
     CDS             complement(24139..25140)
                     /gene="ccpA"
                     /locus_tag="VHC05_000676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002264971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="catabolite control protein A"
                     /protein_id="HEQ5402006.1"
                     /translation="MNTDDTITIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEV
                     IDRLDYRPNAVARGLASKKTTTVGVVIPNIANSYFSILAKGIDDIAAMYKYNIVLASS
                     DEDDDKEVNVVNTLFAKQVDGIIFMGHHLTEKIRAEFSRSRTPVVLAGTVDLDHQLPS
                     VNIDYRAAVSNVVDILAENHKCIAFVSGPLIDDINGKVRLAGYKEGLKHNKLDFKEGL
                     VFEANYSYKEGFELAQRVINSGATAAYVAEDELAAGLLNGLFEAGKRVPEDFEIITSN
                     DSPVVQYTRPNLSSISQPVYDLGAVSMRMLTKIMNKEELEEKEILLNHGIKKRGTTK"
     gene            25314..26399
                     /locus_tag="VHC05_000677"
     CDS             25314..26399
                     /locus_tag="VHC05_000677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HEQ5402007.1"
                     /translation="MTKLDQIRLYLDQKGAELAIFSDPVTINYLTGFFCDPHERQLFL
                     FVYHDLAPVLFVPALEVARASQAISFPVFGYVDSENPWEKIKAVLPNTAAKTIYAEFD
                     HLNVNKFHGLQTIFSGQFNNLTPYVQGMRLVKSADEINKMMIAGQFADKAVQVGFDNI
                     SLDATETDVIAQIEFEMKKQGIHKMSFDTMVLTGNNAANPHGIPGTNNIENNALLLFD
                     LGVETLGYTSDMTRTVAVGQPDQFKIDIYNLCLEAQLAAIDFIKPGVTAAQVDAAARQ
                     VIEKAGYGEYFNHRLGHGIGMDVHEFPSIMAGNDLVLEEGMCFSVEPGIYIPGKVGVR
                     IEDCGHVTKNGFEVFTYTPKELLYFEG"
     gene            26448..27113
                     /locus_tag="VHC05_000678"
     CDS             26448..27113
                     /locus_tag="VHC05_000678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEQ5402008.1"
                     /translation="MDQTIHHQIQQALHFRTAVRVYKEEKISDEDLALILDAAWLSPS
                     SVGLEGWRFVVLDNKPIKEEIKPFAWGAQYQLETASHFILLIAEKHARYDSPAIKNSL
                     LRRGIKEGDGLNSRLKLYESFQKEDMDMADNPRALFDWTAKQTYIALGNMMMTAALLG
                     IDTCPIEGFHYDKVNHILAKHNVIDLEKEGIASMLSLGYRLRDPKHAQVRKPKEEVIS
                     VVK"
     gene            27124..27501
                     /locus_tag="VHC05_000679"
     CDS             27124..27501
                     /locus_tag="VHC05_000679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEQ5402009.1"
                     /translation="MKALHTCIRVKDLDQSVAFYTSAFPFKENYRKDFPDSQFTLVYL
                     ALEGESYELELTYNYGHGDYDLGNGYGHIALGSEHFEADHKKHRQAGFPVTDIKELAD
                     KSARYYFIQDPDGYKIEVIDLNN"
     gene            27646..28572
                     /locus_tag="VHC05_000680"
     CDS             27646..28572
                     /locus_tag="VHC05_000680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEQ5402010.1"
                     /translation="MTLLSIIVPCFNEEANILPYFEEMHQLETSMSNQLAFEYIFIDD
                     GSKDNTLGILRELAARFPNVHYLSFSRHFGKEAGLLAGLKEAKGNYITVMDVDLQDPP
                     ELLPVMYAKLKEGYDIVGTRRQNRQGEPLIRSMCSNLFYGLIKHLSDTEMVNGVRDYR
                     LMTRQVVDSILELGEVNRFSKGIFSWVGYRITYLSFENQKRKYGKSRWHFWELLRYSL
                     DGFINFSEMPLTIATWTGTFSFLISIFAILFIIIRKILFGDPVSGWASTVSIILFMGG
                     IQLFCMGIIGKYISKIFLETKKRPLYIIKEKH"
     gene            28783..29466
                     /locus_tag="VHC05_000681"
     CDS             28783..29466
                     /locus_tag="VHC05_000681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF969 domain-containing protein"
                     /protein_id="HEQ5402011.1"
                     /translation="MEWIKLIGIVIIVLGFILKFDAIATVVVAGLVTALVSGISFIDF
                     LDILGKEFTNQRLLTIFFITLPLIGLSETYGLKHRATQLIQRVQALTVGRLLTLYLII
                     RELAGLFSIRLGGHPQFVRPLIQPMGEAAAKANIGEELTDAEKDDIKAMAAANENFGN
                     FFAQNTFVGAGGVLLIAGTLEQLGYDGNQAKIAFSSILIAIISIIIVAIYNYLFEKKM
                     ERQHQKGDN"
     gene            29466..30392
                     /locus_tag="VHC05_000682"
     CDS             29466..30392
                     /locus_tag="VHC05_000682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF979 family protein"
                     /protein_id="HEQ5402012.1"
                     /translation="MANIANLVLETIYILIGLQLFHTAYCTFKDKTNPVYFGTALFWG
                     LLGVTFVGGAFLPNKVIGFIVIVLALLTLFKQVRIGTLPVFNERKAEESAHRIGNWIF
                     LPVMLMAMISLLLALILPDFSKSAIGIAGILATIAILIITKQKPSALLAENNRMNQQV
                     STSGILPQLLGALGAIFAAAGVGDVIASLIREIVPADSRFFGVLAYVLGMVIFTMIMG
                     NAFAAFTVITTGIGVPFVFALGADPIIAGALAMTAGFCGTLLTPMAANFNALPVALME
                     IKDRNAVIKKQAPIALVLIISHIALMYLLAYY"
     gene            30442..31089
                     /gene="pcp"
                     /locus_tag="VHC05_000683"
     CDS             30442..31089
                     /gene="pcp"
                     /locus_tag="VHC05_000683"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HEQ5402013.1"
                     /translation="MKILITGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVF
                     QKSADVLQQHIESFQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPI
                     RADGKAAYFSTLPIKAMVAAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAK
                     AGFMHIPFMMEQVVDKPNTAAMNLDDITRGIEAAIFAIVDFKDRSDLKRVGGATH"
     gene            complement(31204..31914)
                     /locus_tag="VHC05_000684"
     CDS             complement(31204..31914)
                     /locus_tag="VHC05_000684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutaminyl-peptide cyclotransferase"
                     /protein_id="HEQ5402014.1"
                     /translation="MITKGQVRLLRTYSYDSNLYTQGLEQLNNNHILLSAGRYGFSKV
                     GVYDLTQEIFSEKIAFPDTVFAEGLTVVEDYFWLLTYKEGVAYKFDKTTCNCLGAYPF
                     EGDGWGLAYDKENQCLWMTSGNAFLQKRDPKDFALLDTVLVAIESVPISMLNELEYVD
                     GYLYANIWQTNTIVKLQPDSGKVVATYDISPLLKALNLDKSHYPDLNVLNGIAHLDQQ
                     RFLITGKLYPLMLEVVLD"
     gene            complement(31929..32396)
                     /gene="smpB"
                     /locus_tag="VHC05_000685"
     CDS             complement(31929..32396)
                     /gene="smpB"
                     /locus_tag="VHC05_000685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994152.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SsrA-binding protein SmpB"
                     /protein_id="HEQ5402015.1"
                     /translation="MAKGEGHILAQNKKARHDYHIVETVEAGIVLTGTEIKSVRAARI
                     QLKDGFAQIKNGEAWLVNVHIAPFEQGNIWNADPERTRKLLLKKREITHLANELKGTG
                     MTLVPLKVYLKDGFAKVLIGLAKGKHDYDKRETIKRRDQERDIKKQMKHYNAR"
     gene            complement(32399..34732)
                     /gene="rnr"
                     /locus_tag="VHC05_000686"
     CDS             complement(32399..34732)
                     /gene="rnr"
                     /locus_tag="VHC05_000686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease R"
                     /protein_id="HEQ5402016.1"
                     /translation="MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKME
                     SQSLLRFSDDGSLALRKEREKKKEPTVQGVFRANKAGFGFLHVDENEDDMFIGRNDVG
                     YAIDGDTVEVVVKKPADRLKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRS
                     KNQKIQQKIYIKKEPVVLKGTEIIKVDIDKYPTRGHDYFVASVRDIVGHQGDVGIDVL
                     EVLESMDIVSEFPAEVLAEANAISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAI
                     HIKLLDNGNYELGVHIADVSYYVTEGSALDKEAIARGTSVYVTDRVVPMLPERLSNGI
                     CSLNPNVDRLTQSALMEINSQGHVVNYQICQSVIKTTYRMTYSTVNDMIAGDEEALQE
                     FASIADDVTLMVTLHRILEAMRSKRGALNFDTQEAKIIVNDKGMPVDVVLRQRGIAER
                     MIESFMLAANECVAEHFAKAKLPFIYRIHEEPKVEKLQQFIDYASTFGIHIQGTANKI
                     SQEALQAFMAKVEGQPGAEVLNMMLLRSMQQARYSEHNHGHYGLAAEYYTHFTSPIRR
                     YPDLLVHRMVREYNQPSQEKRDHFAQIIPELATSSSQLERRAIDAERVVEAMKKAEYM
                     AEYVGEEFDGIVASVVKFGFFVELPNTIEGLVHITSLPEYYHFNERTLSLQGEKSGKV
                     FKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKMSDKASRRDRRKSSKSSKGTK
                     KKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS"
     gene            complement(34826..35062)
                     /gene="secG"
                     /locus_tag="VHC05_000687"
     CDS             complement(34826..35062)
                     /gene="secG"
                     /locus_tag="VHC05_000687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecG"
                     /protein_id="HEQ5402017.1"
                     /translation="MYNLLLTILLVLSVLLVIAIFMQPQKNPSSNVFDSSGSEALFER
                     TKARGFEAFMQRFTAVLVFFWLAIALVLAILSSK"
     gene            complement(35108..35254)
                     /gene="rpmG"
                     /locus_tag="VHC05_000688"
     CDS             complement(35108..35254)
                     /gene="rpmG"
                     /locus_tag="VHC05_000688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEQ5402018.1"
                     /translation="MRVKINLECSECGSNNYLTSKNKSSHPEKIKVPKYCPKERKVTL
                     HVET"
     gene            complement(35251..36444)
                     /locus_tag="VHC05_000689"
     CDS             complement(35251..36444)
                     /locus_tag="VHC05_000689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter"
                     /protein_id="HEQ5402019.1"
                     /translation="MNWRQNLKVAWLGNFFTGASFSLVMPFMALYVENLGTPTELVEY
                     YAGLAVAVTALASALFAPVWGKLADRYGRKPMMLRASFVMTFTMGGLAIIPNVFWLLI
                     LRLLTGVFAGYVPNATALIASQAPKEESGYALGTLATGVTAGALIGPLLGGILAELLG
                     IRQVFLLVGVILFLCSLMTAVYVKEEFKPIRRFEMIPTKVILKQVKSPQIMLGLFVTS
                     MIIQISAQSVAPILSLYIRHLGQTHNLMFTSGLVVSAMGFSSLFSSSYLGKLGDRFGN
                     HRLLLAALCYSFIMYFSSALAQTSFQLGVLRFAYGFGVGALMPSINSLLTKLTPKEGI
                     SRVFAYNQMSSNLGQVIGPFIGSNVAVVLGYRSVFYVTSLIVFVNLIWSLIIFRKYIK
                     VKDIV"
     gene            complement(36566..38068)
                     /locus_tag="VHC05_000690"
     CDS             complement(36566..38068)
                     /locus_tag="VHC05_000690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF853 domain-containing protein"
                     /protein_id="HEQ5402020.1"
                     /translation="MTTMTIAKGNQPIALQLGMLNRHGLIAGATGTGKTVTLKVLAEQ
                     LSLAGVPVFLADIKGDLSNLTKAGEVTDKLAARLATIGVSDYQPQAFPVRMWDVFGQN
                     GQPLRTTISEMGPMMLSRLLNLNDTQTGILNIVFKIADEKGWLLIDLKDLQAILKEVG
                     DHASDYSSHYGNIAKQSIGAIQRSLLTLEQEGAHQFFGEPALDVADLMQLDVASGYGA
                     INILSATKLFQSPTLYTTFLLWLLSELYELLPEVGDLDKPKMVFFFDEAHLLFKDAPK
                     VFLEKVEQIVRLIRSKGVGIFFVTQSPLDLPETVLAQLGNRIQHALRAYTPKEQKAVR
                     VAADTFRQNPDLDVARVITELEVGEALISVLNDKGQPSIVERAYIMPPKSSFAVLSEI
                     ESQQLVQSSPFASKYSQSIDRESAYEKLAAKVLEDNRLAQEAIATAQREKEAKEAIKA
                     QAATKKANRRSVGRPRKTVVEKATDAFISTTVRTIGRELVRGLLGSLRKR"
     gene            complement(38258..38851)
                     /locus_tag="VHC05_000691"
     CDS             complement(38258..38851)
                     /locus_tag="VHC05_000691"
                     /EC_number="2.7.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dephospho-CoA kinase"
                     /protein_id="HEQ5402021.1"
                     /translation="MIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRL
                     YEALREAFGNQILKADGELDRTKLSEMLFSNPDNMATSSAIQNQIIKEELAAKRDHLA
                     QSQAIFFMDIPLLMELGYQDWFDAIWLVYVDAQTQLQRLMARNRLDKGKARQRIASQL
                     PIEEKKPYASLVIDNNGDMETLIKQVQSALLSLANPR"
     gene            complement(38848..39675)
                     /gene="mutM"
                     /locus_tag="VHC05_000692"
     CDS             complement(38848..39675)
                     /gene="mutM"
                     /locus_tag="VHC05_000692"
                     /EC_number="3.2.2.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-formamidopyrimidine glycosylase"
                     /protein_id="HEQ5402022.1"
                     /translation="MPELPEVETVRRGLEALVLGQEIVAVTLKVPKMVKTDLETFALT
                     LPGQIIQSVGRRGKYLLIDLGQLVLVSHLRMEGKYLLFPDEVPDNKHFHVFFELKNGS
                     TLVYQDVRKFGTFDLIAKSQLSAFFAKRKLGPEPKKETFKLKTFETALLSSQKPIKPH
                     LLDQTLVAGLGNIYVDEVLWAAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGS
                     TVRTYRNALGADGTMQDYLQVYGQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRP"
     gene            complement(39847..40713)
                     /gene="rgg2"
                     /locus_tag="VHC05_000693"
     CDS             complement(39847..40713)
                     /gene="rgg2"
                     /locus_tag="VHC05_000693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system transcriptional regulator
                     Rgg2"
                     /protein_id="HEQ5402023.1"
                     /translation="MEKELGKTLRRLRKGKQVSISFLADEYLSKSQISRFERGESEIT
                     CSRLLNLLDKLNITIDEFVSAHSKTHTHFFTLLSQARKCYAEKNVVKLTKLLKDYAHK
                     DYERTMIKAILFSIDSSIAPSQEELTRLTDYLFKVEQWGYYEIILLGNCSRFMNYNTL
                     FLLTKEMVASFAYSEQNKTNKMLVTQLSINCLIISIDHSCFEHSRYLINKIDLLLRDE
                     LNFYEKTVFLYVHGYYKLKQKEISGEEDMRQALQIFKYLGEDSLYYSYKEHYRQIVLG
                     GKGDEDWSEADL"
     gene            40802..40870
                     /gene="shp2"
                     /locus_tag="VHC05_000694"
     CDS             40802..40870
                     /gene="shp2"
                     /locus_tag="VHC05_000694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_128650799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide pheromone SHP2"
                     /protein_id="HEQ5402024.1"
                     /translation="MKKVNKALLFTLIMDILIIVGG"
     gene            41784..42053
                     /gene="stcA"
                     /locus_tag="VHC05_000695"
     CDS             41784..42053
                     /gene="stcA"
                     /locus_tag="VHC05_000695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system protein StcA"
                     /protein_id="HEQ5402025.1"
                     /translation="MTKKQFYLILAISILCFILAVSPKPPIPKHTIERKRTAMTIGHS
                     KQNPHKKEALKHKKNKNKTLFLPSGDSAIKSVISMTVRLLLDDQS"
     gene            complement(42401..42799)
                     /locus_tag="VHC05_000696"
     CDS             complement(42401..42799)
                     /locus_tag="VHC05_000696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HEQ5402026.1"
                     /translation="MHRLLNRLIPEEDNNKLSRAAKEVVTEPRLNNPFLLPKKVLSLE
                     DDAAILNHLEEDRNVNKLFLEPVAAEAKREINFHPSDQQVTAKVKESSDFHQKQHQTG
                     ITYGDDTLADLTHHLLHSDGILPSLNDKSA"
     gene            complement(42892..43962)
                     /locus_tag="VHC05_000697"
     CDS             complement(42892..43962)
                     /locus_tag="VHC05_000697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402027.1"
                     /translation="MMMLRDVKVKMSSLLVGCAATLLVSLSSTVAADSVHSSDRRFGV
                     GYKEETTSQFSSDQPSQVVLYRGEANTVRFTYTNQMYLMKDIRIALDGSGKSLTAQTV
                     PGMGHVYEGFQTSARGIFTMSGVPESTVPVANPNVQTKYTRYFKVIDDMYNTMYKGTV
                     FLVQPQAWKYTMKSVDQLPVDDLNHIGVAGIERMTTLIKNAGALLTTGGSGAFPDNIK
                     VSINPKGRQATITYGDGSTDIIPPAVLWKKGSVKEPTETDQSVGTPTPGIPGKFKRDQ
                     SLNEHEAMVNVEPLSHVVKDNIKVIDEKSTGRFEPFRPNEDEKEKPASDVKVRPAEVG
                     SWLEPATALPSVEMSAEDRLKS"
BASE COUNT        13194 a         9584 c         7814 g        13563 t
ORIGIN      
        1 taaattagtt aacaaagatt aattgaaatc attctttatc ttttaacgaa ataccaatca
       61 agggtgtctc aataaaaaat catctactct gacaactttt ctcttttacc tatcgacagc
      121 taaaaagcct tggaaactgc tatttccaag gctttctttg tactctattg tatcaattag
      181 cttattccga tttctgttgc tattagttta atcatgaaat ctcctaactt atggccgaac
      241 atccaaaaaa acagaaggaa ctcccttctg ttttttaatt ggtcatctct tgagcttctt
      301 ttaattttac agatacaatt ttagagaccc ccgattcctg catggtaatt ccataaatac
      361 tatctgctgc agccattgtt cctttacgat gggtcacgac aataaattga ctatctttgt
      421 caaagcgatt gaggaaatcc ccaaagcgct taacatttgc ttcatcaaga gccgcttcta
      481 cctcatctaa aatcacaaac ggaatcgttt taacacgtat aatagcaaac aataaagcca
      541 gtgctgacaa agctttttct ccgcctgaca tcaagttaag agattggatt ttcttaccag
      601 gaggctgcac agaaatctct ataccagcag acaagaggtc tgtttccgtt aaaaccaaat
      661 cagcagaacc cccaccaaac atctgagtaa aggtttcctt aaaacttttt tgaattgcct
      721 caaaagtcac tttgaaacga gccttcactt cgctatccat actattaata gtctctagca
      781 aaagattttt agcttttgtc agatctgtct tttgacttgt taaaaaagtc aaacgctcat
      841 gcacttcctc atactgagta atagcatcac tattaattgg tcctagtgca cgaatagtct
      901 tttgtaaatg gtgtaatttt tctttggcac tttctaagtg atcaatacta tttgttacct
      961 cctttgcgtc tgctagtgtc atttgaaaat cttctgataa acttttagca taggctcgta
     1021 agcgattagc cacttgctct aaatgtgtct ctaacttggt ttgacgacga ataaatatgt
     1081 catttttttc actttctttg gctatttttt ctgctgtttc ttctaagcgg gcctcatagt
     1141 cctctatttc aaatcttaat tggactaaac gtttttgagc accagactta tgctctgtgg
     1201 catcttgtaa ctgtttttgc cactggggta gtctttgaat gctgtcttga cttacgttgt
     1261 tgtttagtat gctttcaagt ttgagaatat tttgctggca ttgcttcagc tgagttctta
     1321 gacgagattg attagcttgc tcaaatttct tttcattaag taaatctctt tcttgcaaac
     1381 gagcttgaga taaagcttgg tgaatgtttt gtgttttttg cctaatcaaa tctttgtttt
     1441 ctttgatatc atcaatatca caagttaaga catttttttt cttagcaata gctgttaatg
     1501 cttcctcaat acgagcttgt tctgccaata aagattcatc agaatgagtc gtctgacttt
     1561 gatcaagagc agctaacaaa gtctttgaat cttcttgttt ttcttgcaat tgctgataag
     1621 ccatttgagc tctttgttca gctaagcgtg cctggtcacc ggctaatttc aattgtgtca
     1681 gttcttcttt ttttgctatc aaatcgcttt gcaaggcagc tacttctttt tcagttattt
     1741 ttaattgctc aactaatcgc gttaattcct cactgatttg ttctaactct ggtttgataa
     1801 aagttgtatt gctttgtcta ttagctcctc ctgaaaaaga accacctggt cgtaattctg
     1861 ttccatcaag agtaacaatt cttaccttat atcctaataa gcgcgctgca atattagctt
     1921 gatcaatagt ttcaaagata gcagtactag ataaaaggtt ttggataata gctgaaagac
     1981 tatcatcata gcgaaccaat gattctgcag ttcccagata accttcacaa gtcgccaatt
     2041 gacgatgata gtgttctgat aatgatctag cctttatagt agttaaaggt aaaaaagttg
     2101 ctcgtccttg gcgatttttt ttcaaataag caattgctct ttttgctgca gcttcgtctg
     2161 ttacaataat atgctgacta ttagcaccta atgcaatttc aagagctgtt tggtaatcag
     2221 aatcaaaaga aaggtgttca ctgactgcac ctatgatccc tccaagcttt ttttgtgatt
     2281 gaaggacagc tcgtactccc gcatagaatt gactatgact tttttgaata gattctaagc
     2341 tagccttacg agcttctttt cctttttttt gatccaacaa gtcaaatagt ctttcttgat
     2401 tcagttggta atctctttct aattcctgaa cgcgtttatc accttcttga taattttgga
     2461 gcaacatttc gacttgctct ttttgagctt tataatgagc ttgagctttt tgagactcgt
     2521 cattaagttg atcaagctta gtaacaagta gctgatattc ttgagcctta tgttgacgag
     2581 cctgtttttc tttgtctaaa tgggctttta aagctgtcag ctgatttgat aaggccgcct
     2641 ctttttgcat caataataca aactcttctc ttagagtttc cattaattgg tcgggatcac
     2701 ttgaaaaacg ctctaatgca ttgctcaatt cgtttaactg ttgtttgaca tcacaaagtt
     2761 gttgatcaat atgcaataat tgttctgtac gctgcttttc ttctgcttga aaaccatcca
     2821 attgttcttg taactgttcc agatgttttt tggcttctgc ctttttctct gcttcttggc
     2881 cactttctag cttaaccaat tcaatttgct tttccaagtc agctattagc ttggttaatt
     2941 ctaataatgt tgtttgggtt tgatctgact cttgactaag aacctgcttt ttttgcttga
     3001 atttttggta atcttcttcc atagattgac gcttagcgta ataagatgct aagtcttgtt
     3061 gtaaagcagc taaagcttca gtatctttag tctgtctttc ttgagctata tcaatatctt
     3121 tgactagaat atctagttgt agttgcttac gattggcatc aagttctaaa aattgtttag
     3181 ctactttagc ttgcttttca agtggggcca actgcgtgtc tagctcataa ataatatcct
     3241 ctagacggtc taaattatct tgagtttgat ttaatttaat ctgagtttct tttttacgtg
     3301 ttttatattt taaaacacca gctgcttctt caaaaatggc gcgcctttct tcaggtttac
     3361 tattgaaaat ttcctctaca cgaccttgag aaataatgga gaaagaatca cgaccaagcc
     3421 ctgtatccat aaacaaatca tgaatatcac ggagccttac cttgcgacca tcaatcagat
     3481 agtcactatc tccatttcgg taaatatgcc tttcgacacg gatttctttc ttggcagttt
     3541 ttataaaatg atcggaatta tcaagaacaa ccgctacctt agcatagttt agaggattac
     3601 ggttttgtgt cccagcaaaa atgacatctg gcatcttgcc cccacgcaga tttttagcac
     3661 ttgattctcc taaagcccaa cgtaaacttt ctgtaatatt acttttacct gaaccatttg
     3721 gtcctacgac tgcagttact cccttatcaa attcaatttt agtcttgtcc gcaaaggact
     3781 tgaacccttc caactcaatt tcttttaaaa acatctaaac ctcactaagt tgggcaaggg
     3841 catttttagc agcatcttgc tccgctaatt ttttagactt acctaaacct ttactaagga
     3901 cagcaccatt aacaactatc gatacctcaa attgtttagc gtgggcaggt cctttctcac
     3961 taatgacttg ataatcaata gccacatcac cttttgtttg caaaaactct tgaagacaag
     4021 ttttatagtc tttaaccctt tcaaaattcc ctttttccac ctgaggaatc atgacttgtt
     4081 tcaagaagcg acgtactgca tcaatcccct tatctaataa aagagcacct aaaaaggctt
     4141 caaataagtc tcctaaaata gtatcacgac ggcgaccacc tgacttttcc tcaccttttc
     4201 ctagtttgat ataagcgtca aaagaacaaa atcgtgaaaa acctgccaag ctttcctcac
     4261 gtacaatcat ggaacgtaac ttagacatat ctccttctgt ctttttagga tactttgcaa
     4321 ataaatactc tgaaataatc aattgtagaa cagcgtctcc taaaaattcc aagcgttcat
     4381 tatgtgaaac gtttaggaga cgatgctcgt tagcgtaaga ggtatgggta aaagctgttt
     4441 ctagtaaagt caaatcatta aattgaatat caaaagatgt tgagagtaac tcttcaagct
     4501 gtttcataaa aaatcccttt catatttgtc agtagacctt atttagtata ccaaaaatcc
     4561 acctagaaaa ccgactctaa gtggattttt cgtgatttat taaacatctt aaatacccgt
     4621 caaaggaaac tttctcatac aatcaaaaga ctctacacta tctgagggga atttcccact
     4681 acagtcccac tacagatagt atagagctat tttgttttta gtctgaacaa ctaaaaaact
     4741 accttatctt tataatcctc aacacctttg ataaatagat cagacaagcc aaaactacag
     4801 gctaatttaa gtctattgat gctctaaagg ataaccaatg agagttcatt gaactcagaa
     4861 gacaatacgc tttaagacat caaaaaatag ccctgactgg tatatcacca atcagcgcta
     4921 ctttgcatat tctcttttag tttcttatct caaatatcag ttaatggaca agcagtatct
     4981 ggagaggtat catggaccgt aaagtctgta cctactgcta aatctgccat agccagttga
     5041 ttgaccatcg tcatatgcgc taactctttg atgttatttt ctttactcag atgacctagg
     5101 tatatttttt tggtattgta ccccaggctt ctaatcatgg ctcccgctcc atcttcattt
     5161 gataaatgtc ctaaatcaga taaaatacgc tgcttcaagc tccaaggata agagcctgat
     5221 ctcaaaattt caatatcatg attggattca atcaagtagc catctgcatt ttcaataata
     5281 cctgtcatcc tatcactgac atatcctgta tctgtcaaca tcacaaaaga cttattatct
     5341 ttcataatcc gataaaattg aggatcaata gcgtcatggc tgactccaaa actttcgata
     5401 tcaacatctc caaaggtcaa aactttatcc ctttggaaaa tatgtttttg tgaggcatca
     5461 agcttaccta gcatattgca ctcatccatc agctgccatg ttttttcatt agcatagata
     5521 tccaaatggt atttgcgggc cataacgcct acacccttaa tatggtcaga gtgctcatgg
     5581 gtaatcaaaa tagcatccaa atcctcaggt ttgcggtcaa tttcagcaag aagactggta
     5641 attttcttac cagtaagccc tgcatcaatc aataagcgtt ttttaggtgt ttctaaataa
     5701 aaacaatttc ctgtggaccc agatgctaaa atactatatt taaaaccact ctcattcatt
     5761 gattagtcta catcttcctc ccattcttca tagatggctg catctttttc ataaggcaag
     5821 acaatagtaa aggtcgatcc tttaccatag tcactcttag cccagataaa gccatggtgc
     5881 tgcttgatga tttctttagc aatggcaagg cctagaccgg tccctccttg ggcacgactt
     5941 cttgccttgt ctacacgata gaaccgatca aaaataagag gcaaatctgt tttagggata
     6001 cctagtcctt ggtctgaaat ggaaataatt aattgggtat ctgttgtttt catacggact
     6061 gtaatttttc caccatctgg agaatactta atggcattgt tcaaaatatt ctcgataacc
     6121 tgtgtcattt tatcattatc aatttcaagc cagacagagg taatagggta atctcttaca
     6181 atttcataga cttttcctgt acctgtatgc tgatttttaa ccaaatcaaa tctgtttaaa
     6241 atagaagtta taaaagcagt aaaattagtc atctctactg ctaattgggt tacttgatta
     6301 tcaatccgag acaggtttaa aagatctgaa atcatacgca tcatccgatt agtttcatca
     6361 agagaaactt ttatgaaact tggagcaata tcttctttaa gtgcaccttc atcaagagcc
     6421 tccaagtagg atttaaccga agttaaaggg gtccttaatt catgacttac attagaaaca
     6481 aaaagacggc gttcacgttc ttctttttct tgttctgtgg tgtcatggag caccacaacc
     6541 aagcccgaaa taaaaccact ctctctccta ttcaacgcaa aacgcaagcg taatgagaca
     6601 aactcaccca tatcatttcg gctattaaca gttaccactg gtgttttgga taccaaatca
     6661 cggtaggtat atgaagtatc accttctaac aaatctgtaa tgtttttctt tagtgcctct
     6721 tctttactta aatttaattg cttgcgagct gtctcgttaa tcatgatgat tttaccagac
     6781 cggtctgtag caagtacacc atctgacata taagccaaaa tacttgccaa gcgatttttt
     6841 tcttgggcaa gattttcatg cgtcaagcga aaaacatctg acaggtcatt taactggtct
     6901 gaaagctcca ttaactcaat gtctgctttt tcgtcgatta tatcagtata gcgaccatta
     6961 atcaagtctc ggattttatg gctcatcatc cgaataatac gtgcatttcg gtaatcacgc
     7021 accgcaagat ggataaagta aaaagcaaca aaaacaagta agataaggat cgctaattca
     7081 aatgtggata agtttccaat gatatctcta gtcataagat ttcatgtagt acccaacacc
     7141 acgtcttgtt aaaatatact caggacgact tggtgtgtct tcaatttttt cacggagacg
     7201 acgaacagtc acatcaaccg tgcgcacatc gccaaaataa tcatatcccc aaacaatttc
     7261 caataagtgt tctcgtgtca tcacctgacc catatggtta gctagatgat gcaatagttc
     7321 aaattcacga tgagtcaact ctacctcttg accatgtttt ttagcaacaa acgcatctgg
     7381 taaaatctgt aaattaccaa tggttagttc ctgtgtacct gaagaagcat tttcttctgc
     7441 aacagccgtt tcaatagttt cggtacgacg cagatgagcc ttgacacgcg ccagcaattc
     7501 ccgattagaa aagggcttgg tcacgtaatc atcagcccca atttcaagtc caataacctt
     7561 gtcaaactca ctatctttag ccgacaacat aataatcggg acatgactgg ttttacgaat
     7621 ttccttggct acttcaagac cgtccaactc agggagcatc aaatcaagaa taattaaatc
     7681 tggcttttct tcttcaaaaa tggttaccgc ttcgcgtcca tcaaaagctg taacaatgtc
     7741 ataaccttct tttgtcaaat taaacttaat aatgtcagaa atcggttttt catcatccac
     7801 aataagtatt tttttcatgt ctacacctca gaaagttctt gtaattgata ttacaatttg
     7861 tgatttttgt ggttaataaa aaatcacaaa actatatttt tctaaattat ttctacctga
     7921 ttataccaaa aattcagcct aattgacaat gacgactacc gttacaaata gagtactttc
     7981 taaaaccaac cctttatagg atgaatttgg cgtttgaatt gcttagcaga ttttttgact
     8041 ctggcaaaac tactcttgtt gtggtaagca aaaagtcctt tggcattaaa ataagagaac
     8101 ataaagtcat ctttttgagc tctaaaccac tgacgaaata ctctttttgg cgttcgaaat
     8161 cctttaaggg tgtctcttct aaactgagga tcgtgacggc taatcggatc aacatctaaa
     8221 tcccaatgtc taggaccatc tgtgccatag ttaaaagatg caccattgac aattcctttt
     8281 tcggtcacta tttctgcatc aacttcatta agaaaaaagc ctgtgctatc tagaataaat
     8341 tcggtatgaa accaaagaag tacttttata ttataggaaa cttcttgact tggaaaaatg
     8401 actttattat cttcaaatct tagtttatta tgtaacctgg cagaatccat caaggtataa
     8461 tctggtgctt gccgccacaa acaaggccct tttttagacc tcaaaaaaag ggccagagct
     8521 tgggcgtctg tcatctcaat cattttataa tgatttctga tagattgagc ttgttgacta
     8581 gagatgacat aacgaaattg atgcaaacgc ttttcaagat cacctgcttg gcttagtgtt
     8641 ttgccaggaa aagcttgatc aactaagcta gccaactctt tccaaaatat atgatctggc
     8701 aatagagatg gatggaatcg ggtgagtagc gtttgagttt catgcaactg accacttagc
     8761 tcaaatggca tctctaccaa atcaagaaga aacgttagta actgcttagc tgattggttt
     8821 tctttttcaa taggccatat tacccagaaa gttggagaac caagtcgatt atcaatgata
     8881 ggctctttag ctatagcacg aaatgcttgg tttgataaac ctgcattttg atagcatttc
     8941 aaggcctgat agcgatctaa gatagcttgt ttcatggcct tctcctcatc ttttttgacc
     9001 atattataac acatctaaag ctgaatcgtc acttgtatct cactataagc aaaacgaaac
     9061 ctgaaatcgt taactaagcc actgtttggg tattttattt aaaagaactt cttgattaat
     9121 tttaccatta tcttttaaag gcaaacaatc aatcacaaga tagtacttag gaagttgtcc
     9181 agagtttaaa taaagagcta aaaagtcttt aataggtgct aggcaatcct tcttagtcaa
     9241 aactaatact aatattaggg tttcgttttc tccttttcct atctttaaag cgtgtgcttc
     9301 tttgacgttt ggcgcttggt gagcgagttc aactaggcta ggcaggtggc atttcactcc
     9361 tcgttgatta acccagtcat cttgtcgccc ttctaaaatt aaacccgctg ggctcatttt
     9421 tcctaagtct gagacactgt atggttgtga cattccttct acactataag gagtctctac
     9481 aaaaatttcc ttatctttga aactgataga cacatcagga aagggctgtc ctaccaaacc
     9541 attaattttg acagcagctc tgccattaca ccacgttata aaagataatt cactagcccc
     9601 gtagaaaatg acaatttcaa gctgaggaaa ttttttgtaa taatgtctta gtaattcttg
     9661 tgatatcatt tgcgaagagg tcaataagtg agtcgcagtc atgttgttct tagtcaaata
     9721 aggtagcaag cgatttaggt aagtcggtaa aaggtaaagg tgactcacct tttttgcttg
     9781 ccataagctt aaccacgttt tcaaagacag cttttggctt aaaaccagac atcccccggc
     9841 ccatagttga gctaatgcta agttaagatt gccagtaaaa ctaaaactac catgtaagaa
     9901 tagacaacta ttaccagtca taccaaacac cttattttga taatcaaaaa gtctcgtcca
     9961 agttgataga caacgccaaa ataattttgc tttgccagtt gttcccgaac tcaaaacagc
    10021 aaaatcagct tttttaagaa gctcactatc gacgtgtttt atttgctgct gaaatgtacc
    10081 tgagatatta gggtgtaaaa tgataggaca actgccttct tttaatcctc gtaaaaaaga
    10141 gagtaactga ttaagatagc gactatgact gatgatatat ggtacactgt cttttattgt
    10201 ctgatccttt attagaaccg cttgccatag ctcttgataa gtcaagctta tctgatcggc
    10261 tacgatagct tttttatttg ggcattgctt tgcccaatat tctagctttg tcagcatgac
    10321 taaactcctt atgattattt tagtaaaaca gcaaaccctt ggccaccagc tgctgctata
    10381 gcagctattc catagcgtcc atttttgatc tctaaagccc tcattaagtg caatattata
    10441 atggctgctg aggcaccgta gggatgacca taagctaatg caccaccaaa tatattatag
    10501 cggtccaata aatctggata atgggtttca aatagaccat caataacggc aaaggcttcg
    10561 ttccattcaa tcgctgtcat atctgccatc cctagaccat gtttttccaa aaggacttga
    10621 ctagccttaa tcaccattaa agggctacgc tgtgggtctc ctgctacttc taccacatca
    10681 atcagtttaa aagctgaagg ctgactactt agctgtaaaa aggcagcagc atcatgggtg
    10741 aggcaggcat tggctgcact aatcacgtga ccttctccta agataggggg tacctttgac
    10801 aacaccttac ttgacaagcg cggtcgaatg ccttgatcac tggcccctgg caggtctaat
    10861 ataaggtcaa ctaacaaggt ttgctcctgg caataactag ccttttgatg actcttcaat
    10921 gtccagtgat tcaaatactc ctttgtaaag ccatgttctc ttgccactcg ttctgccccc
    10981 tcaaccatcg caaatggact attggtgtcc ggagaaaact gggcaacttt gtaagggcct
    11041 tggcgccaat cagctgaagc atataccgat tcaggttgta aggagctact ttcaatccct
    11101 cccactaaaa ggttacttgc catacctgcc ttgattttag cataacctag agcaaaggct
    11161 gcaccagctg atgcacactg catatcaacc gtcaaagcag agacagattc tcctaaatga
    11221 gaatacaggg tcatcaagcg cccaatatta ccacccgttc cgacggcatt gccacaaatc
    11281 acttggtcaa tgggaactgg atacttattt tgtaaagcat tgatgagctt tgctccaagg
    11341 atttctggtt gttctttagc aaattgtttc cctactaaac cgataggggt tctaaggcct
    11401 gcagcaatat aaacatccgt catggtcata atctccttta gctactaatt taccagcctg
    11461 aaacaggcca atggctctac ctttcatcat caattggata gagctatcta aaaccactgg
    11521 cgcataaaag cgcaaatgta attgacgata atcgatagct aacttatcac tcacctgctc
    11581 gagtaagaat gctccgggta aaacataagg cacttctcgg tgaataggtt tttgatcccc
    11641 ggtatcctct agaaagtgag cgagggcagc ttgactgata tttattgtct gatcatcatt
    11701 tgctaaaaac ttattagcct tttcttctaa ttgattacta ttggtggatt ctgataacca
    11761 ctgaaccggc tgcttcttca agaatcggac ctcaagcgtc agccctgatt cactcaacct
    11821 tattttccgg aaacgttggg tatccgtgag cacttgattt tcatataatt gcacagcttt
    11881 ttctaaggtc atgtcaacca ccaggctgtt ctttggtaaa tcttggttgc acttaatcat
    11941 ggtacttagt agtcttctca ttgtcaccct catttttcaa tcacgttaac tttattatac
    12001 tgaaagctcc ggtccaagaa aagggaaaat ctgtaaaaga acacttctta gccaccaaaa
    12061 aaagttgagt cctagaccca actttttttg gttcattaca tcatatttaa aatcacttga
    12121 taaatcaagg cacctacgac cccaccaagg attggaccta aaactggaat ccaagcgtat
    12181 gaccagtcag aatctccttt atttgggatt ggaagtaagg catgcatgat acgtggccca
    12241 aggtcacgcg ctgggttgat ggcataacca gtggttgctc caagtgaaaa accaactgcc
    12301 ataaccacaa aaccaacaat aatcggacca aaaccagcag ctactttatt agggccaatg
    12361 gccattaccg taatcactaa aacagctgtt cctaaagctt cgcccaaaag gtttgaccaa
    12421 gcgtggcgaa tagctggccc agttgagaaa caagctaaaa tcgtaccagc atctttggtt
    12481 tccttccaat gtgggtagta atgcaagtag agaactaagg ctccaagcat tgctccaaga
    12541 aattgagcca caagataagt cactacctga gaccatggca atgagccaat ggctgccata
    12601 gcgagtgtca cggctgggtt taaatgggca ccactcatga aaccactaat ataaaccgca
    12661 acggttacag caattcccca gcccaaaaca atagcaatcc agccactatt ttgagctttg
    12721 gttttattca agatacaagc agaaaccaca ccgtctccta ataaaaccaa aataaacgtt
    12781 cctaacagtt caccgataaa attcatgata atctccttgc tatttattta ttgatagcta
    12841 actcttctaa ctgacttaaa atagcatcct tgtccgcgcc agcctgaata agagctgctg
    12901 ctgtgtaagc cccttcgaca atgggaacca cattcaaggt aatgatcttg tcagaaaaat
    12961 ctgaaaccat ttcgatattc atgcgggcag atccaagatc aaagaaagcc aataagtcat
    13021 ccttaggatt ggcgtcaacg atagcctgca cttggtcaaa actggtgccg ataccaccat
    13081 cttctgtacc accgacatag gtgatggcaa catctgtcgc cacctctgaa atcaggtcga
    13141 caactccttg agcaatattt ttagaatgcg atacaataat aattcctaaa tttgacatta
    13201 aaccacctct gcttccaaca tggcttcaaa taagagtcct gatgagaagg aacctggatc
    13261 aatatgaccc actgagcgtt ctcctacata agaagcgcgt cctttagttg cctggatgtc
    13321 tttggtagct aaaacagcct cttcaaccac atccttggtt aacccgtcat ttttcaaggc
    13381 ttcaatcaca ggaatccaaa catccaccat ggttttctca cctttttctg ccttaccacg
    13441 tttttgaatc atgtccaatc cagcctgcaa agcatctgcc aaactgctat cctcactagc
    13501 ttttgaaagc cccataaagg cagaaccata caatgggcct gaagctccac caactttgcc
    13561 tagcaactgc atagcaacga ccttaaagac atccgctgcg ctcgcaaatt ctttaccgtc
    13621 aagattttcc atcacagcag acatcccgcg cgccatattg ccaccgtggt caccatctcc
    13681 gataggcgta tccaattgac ttaaataatc cttattcact tgaattttat cattaaataa
    13741 ggtcatccat ttgattgcat cttgtgcttg catgatttcc tccttaccaa gctggtgtga
    13801 taacatctga ttgaagagct tctgtccatt catccttgtc aagtttgatc aaggtcaaag
    13861 acaaaccagc catatcaata gacgtcatgt agtcaccaat tttcttgaag ctgactgtga
    13921 catctttttc tgctaagagt tttgccacat cattcgcaaa aacgtattgt tccattaatg
    13981 gtgtagctcc caaaccattg accaagacgc cataatgttg tcctgcgctc atgtcaaagc
    14041 tatctgccaa tttagtcacc aactcttgag ctaatactga tgatgattgt aatttttctt
    14101 ttttgtagcc tggttcaccg tgaataccga caccgtattc aaactcatca tcttcaagca
    14161 caaaaccagg tttgccaact tcaggaacag ttgctccaga aagagctaaa ccgatagttt
    14221 taatatttag gaccaattca tcagcaagag ctttaatatc tgctaatgat ttgccctcac
    14281 gcgcagcatg tcccaaaatc ttgtgaacaa gaatggttcc cgcaacccca cggcgtcctt
    14341 gagtgtagag gctattctca accgcaatat catcatcaac gacaacactg gcaacatcaa
    14401 taccttccat ttctgctaat tcttgggcca tttcaaagtt cataatgtca cctgaataat
    14461 ttttgatgac cataaagaca ccagcacctt catcagctgc tttgatagct tctaaaattt
    14521 gatctggagt tggggaagta aagactgcac cgcagatagc tgctgacaac atgccttcac
    14581 caacaaaacc agcatgagat ggctcatgtc cagaaccacc acctgaaata agggctactt
    14641 ttcccgtctt ctctgcttta cgaacaatca catcataacc atctaggcgt tccactaagt
    14701 catcatgcat ataagctaaa ccttgcaaca tatcgtccac aatctgagtg gcatcattca
    14761 taattttttt catggatctt cctccgattt tttgtttacg ctttcattat aaaatagccc
    14821 ctcccaaaac gtaagggaca aatcctcaga tttgtccctt ttctttctaa aatgcctttg
    14881 ataaggtata atggcagaag atatttcata ttaaaggatt acttatggca acttctctca
    14941 tcaccaagaa aaaaattgcc aaagctttta aaaagcaact agcagtgaaa agctttgata
    15001 aaatttctgt cgttgatatt atggatcagg cccaaatcag gcgccaaacc ttctacaatc
    15061 attttctaga taagtatgaa ctgttagact ggatttttga gactgaactt caggaacagg
    15121 tcacacacaa tctcaattac atcagtggct ttcaactgtt agacgagttg ctcttttatt
    15181 ttgaacgcaa caaaacgttt tatgcccaac tatttgatat caaagggcaa aatgattttt
    15241 acagctactt tgtggactac tgtcaggtct taatggctaa aatcatttct gaataccaaa
    15301 gtcaagaaat gagccaatct gatgctgctg attatcttgc ttttttaacc cattatcacg
    15361 ctagggcatt agcagatatg attaaaggtt atgttagtca gagtgagcct aaaccttgtc
    15421 ttacctatct caagcagctt atcttaacca gcattcatta aacgaggaaa acgtcatggt
    15481 aaccatatta aatcaaacac aaacacttat ttcccaatat atagcaagtg tattagcagc
    15541 ccatccccac ctagcccaat tacaggattt gcctattatt tataataggc atctcgatga
    15601 tcaacttatc ccaattttat ccggaggagg atccggacac gaacctgctc attccggctt
    15661 cgttggtgat ggtatgctgt cagctgctat ctatggcgat atttttactc ccccaactgc
    15721 cacagacatc ttagaagccc tgcgatttct agataaaggt aagggggtct ttgtcattat
    15781 caaaaacttt gaagctgaca ttcgtgaatt tagccaagcc attcatctag cacgacaaga
    15841 aggtcgtaac atcaaatata ttatttccca cgacgatatc tcggttgaac ctaaaaagca
    15901 attccaaatg cgtcaccgag gactcgctgg aactatattg cttcacaaaa tcttaggagc
    15961 agctgcacaa agtggggcaa gtttggatga ccttgaacac ctagcttttg accttgccac
    16021 agagattgct accatcggat ttgcaaccaa atctgctagc ctacccaatg cggcactacc
    16081 tctttttgac ttgcctgatc atcagatttc atatgggatt ggtattcatg gtgaagaagg
    16141 ctatcgcacg gtcccattta tgtcatcaga gcatcttgct gtggaaattg ttaataagct
    16201 tcaaattaaa ttccattggc aagaagacga acattttatt cttctagtca ataatttagg
    16261 aacagcaacc gacttggaac aaggcatttt tctgaatgat atccatcaac ttttagatct
    16321 tgaagggctt catcttcctt ttatcaaaaa tggaaaattc atgactagcc ttgacatgac
    16381 tggtatctct gttacccttt gccgtcttaa agatagacag tggctagact acttacaagc
    16441 tccaaccaat gcctacgctt ggtaaaccag cacaaaaaag gcagccgttt ttacaacagc
    16501 tgcctttctt cattaactag gttttcatat tctgacctaa acgattttca atttgtttaa
    16561 gagtctctct aggaaccagc actttcataa gcacctagtc cccatttcca aagcttaagc
    16621 gacaaggcca aaaccagtaa cgacaccact accaagcctc caatattaaa gagcaggtgc
    16681 tgacctgtta aaaaataaga agcagggtaa taagctgtaa aagcaaaggg aatgacaaaa
    16741 ctgattaacc accgcaaaaa ggaatggtaa atggacatag gatacttgga aaagtcatta
    16801 aacatgtaaa aaatatagat aactgcccca gactgcttgg tccaaaaaga aatgctggcg
    16861 gtagcaattt ttaaagaggt gtaaatcaag gtcgcaaaag gaataaccag aataaacaaa
    16921 agcaccttag gaagagtcca tacgatacta ccagccgtgg tcactaataa gataacccca
    16981 accaataatt cacccaaggc atccacttga aatgtctcaa ccaaaacatg aaacaaagga
    17041 ctaattggtc tggtgaggta cttgtcaaat tctcctttgc ggacaagccg ttgccctaaa
    17101 gcccaaagat tgtcaaaaaa gaggtgatca attccctttg gaatcaaaga aaagccataa
    17161 ataaaggcaa tttgttcaaa cgtccagcct tctaaagaag ggatatgttg gaaaagtacc
    17221 gataaaaaga gcagattaag tccctgagtg agaaaaacac ctagcactcc caccacaaaa
    17281 tcaaccttgt attccataat ttgtttgagg tattgtttga taaaaatagc gtgcatacgt
    17341 ctcaattttg ccatctcacc ctccttgaat cgttaaatgg tactgaacct ttttccagat
    17401 gacttgcgat aagactacca tcaccagtaa ccaaaaaatt tgcaaactta gggccaccat
    17461 tatctgacta aggctgtatt tcccaatgac aatcataact ggcgtgtaaa ccaaagagga
    17521 aaacggtaga aaactaagca ctatagaaac cactttagga aaaaaagcca atggaatcaa
    17581 actgcctgac ataaaggcaa ccaaggcatt ctttaataag ttagaacccc aaaggttttt
    17641 gaaaacaaag gcagaaaagc caaaacagat attgaaataa aaattaatca agaaggccaa
    17701 taaaagacta agcaggtaga gaaacacagt agctagaagt tgccagaacg acattcccgc
    17761 cattagtttg attccgaaaa tcaccaccaa aaacggaaag ccaacactga tgagaacaat
    17821 ccaccgaaag cctatctcca taaaaaggta agaagccgca aagtgaactg gccgaagcaa
    17881 ccgcatgata atagacccat ctttcacttc ctcaccaatc ataaaggagc tatccgattt
    17941 cgttaacaaa gccgtcacaa aactcatgat aatataaaag gtcatatctg acagagtaaa
    18001 accattaatc aaggactgtt tggaggaatc aaacacagcc ttccaaagat aaaaagccac
    18061 aaaagctccc ataacatccc ctagtcgata gagaaagaaa ttgacccgat aagtcattaa
    18121 ttcttgaatt cctgcactga taaagggctt atagcgtttc cagaatgatt gcatgtcaca
    18181 gctcctttcg gtaaaaacga cggatgatat cttcaatatc agcatctgtc attttcaggt
    18241 ctctcaccac aaaatcagcc atggttcgtt gaataacatc tgctgtttgg taacgggaac
    18301 tgtcatattg aatttccaaa gttaattcgt gtcgttccac agttatatca ggcaaaccaa
    18361 gaaactgaga aacaacttct tcctgtcccg cttccaattc aaaagataag cttttcatct
    18421 tcccaaatgt ttgtttgagt tgagtcaccg tgccatcaaa gatttcttgg cccttatcaa
    18481 tcatgataat ccgatcacac agttgttcaa tatcactcaa atcatgagtt gtcaacaaaa
    18541 tggttgtctc ttcttcttga ttaatctgag tgatggcacg tcgaatattg tctttgacag
    18601 aaacatccaa gccaatcgtt ggttcgtcta aaaaaagcac tttcggatta tgcaataaag
    18661 aggctgcgat gtcagctcgc atgcgttgtc ctagggacaa cgttcgaaca ggatccttaa
    18721 taaactcgtt aagttctaaa acctcattta aaaaatccat acgcttgcga aagtcttttt
    18781 caggcacatc gtaaatttct tttaacacag cataggtttc ctgcaaggcc aaatcccacc
    18841 acagttgggt ccgttgccca aaaacaacgc caatatcttt gacataatct tgacgattat
    18901 cttgcggaat cttcccgtta atgcgacaat acccagatgt tggctttaaa attcctgtta
    18961 acatcttaat tgttgttgat tttcctgcac cattggcgcc aataaaacct aaaatttgcc
    19021 ctttgggtac ctcaaaagat aagtccttaa ccgcctcaaa gatttctctt tggggatgaa
    19081 caaaggactt caaggctccc tttaatcctg gctctttaat ggttttggaa aaattttttt
    19141 gaaggtggga cacttctatc atgaccattt accattcctc gtttctatta tcgtcttatc
    19201 accgttacta aacaatttat tataacacca tgaaaaagac ggtgcaaccg tttgcttaat
    19261 tttttaagaa agaaaaagaa gcccataagg acctcttttt gccattgatt aagcttgtgc
    19321 atctggacgt gacttgcgag caatgtctgc caagatgttt tccacaaatt cttccacaga
    19381 ttcggtgtga gtcgccttgc taccatagcg gcgaacattg actgatttgt cttccatttc
    19441 tttgtcccca acaattaatt ggtaaggaat tttgctggtt tgagacgcac gaatcttgta
    19501 ctgcattttt tcattacggt catcgacatc tgcacgaaca ccgcggtcac gaagggtttt
    19561 tgctacttcc caagcatagt caatgtgggc ttcatttgaa attggaatca cggttacttg
    19621 gtgaggtgcc aaccaagttg ggaaagcacc cttgtaagtt tcaataagga tagcagtgaa
    19681 acgttccata gttgagataa caccacggtg aatcatgact ggacggtgtt cttcgccatc
    19741 tgcaccaatg tatttaaggt caaagcgttc tggcaacaag aagtccaact gaatggttga
    19801 tagggtttct tcgttaccaa gagctgtttt cacctgaata tcaagcttag gcccataaaa
    19861 ggctgcttca ccttctgctt caaagtaatc tacacccatc tcatcaagtg cagctttaag
    19921 catactttga gcattttccc acatctcatc attgtcataa tatttatgag tatcgttagg
    19981 gtctcggtat gacaaacgaa aacgataatc agtcaagttg aagtcagcat aaacatcaat
    20041 gattaattga agggcacgtc gaaattcttc ctggatttgc tctggtgtta cgaaaatgtg
    20101 gccatcattc aaggtcattt cacgtacccg ttgaagtcct gatagggcac ctgatttttc
    20161 gtaacggtgc atcatgccaa gctcggcaat acgaataggc aattcacgat aagaacgcac
    20221 atgattttta tacacttgaa tgtggtgtgg gcagttcatt ggacgaagaa caaactcctc
    20281 accatctccc atatccatta cagggaacat atcttcttga taatgatccc aatgacctga
    20341 tgtcttgtac aattctacag aagcaagtgg tggtgtgtaa acgtgttggt agcctgatgc
    20401 taattcttta tctgtgatgt agcgctcaag tgtacgacga atagtcgctc catctggtaa
    20461 ccaaaacggc aagccttgac caacttcttg gctaatcatg aacaagtcaa gctctttacc
    20521 aagcttacgg tgatcacgtt ctttggcttc ttctagacga gtcaagtaag ctttgaggtc
    20581 ttttttatca aaccaagctg ttccatagat acgttgcatc atgttattgt cgctgttacc
    20641 acgccagtaa gcacccgcca cattgagcaa gtggaagact tggatacggc ctgttgatgg
    20701 cacatgaggg ccacggcaaa gatccacaaa ttcaccttga cggtaaaccg tcaagccagc
    20761 accagcatgc tcattaatca attctacctt gtaaggatca tctttgaaca attccaaagc
    20821 ttcttctttg gtcacttctt cacggataca tgggtaattt tctgtcacga ttttttgcat
    20881 ttcagcttcg atacgtggca aatcttcgtt tgaaatttgg ccttctgcat tatctgtatc
    20941 atagtaaaag ccttctgcaa tggcagggcc cacacccaaa tgaagatttg ggaacaagcg
    21001 ttttgcagct tgggcaaata aatgggctgc agagtgacga agcacctcat aagcatcttt
    21061 gtgatcaggt gtcacgattt caatactgcc atcttcttca atggcacgag tggtgtcaat
    21121 gagttgatca ttgaacttac cagctaaagc ttttttagcc aatgatttgc tgatggactc
    21181 agcaatgtca aacgttgtta cgccagattc aaattcacgc acggcgccat ctggaaaagt
    21241 aatcttaatc atttgctttc tcctttaagt cagttaagat ttccactaaa acatggatag
    21301 taagacaaat tagggacaag aggttagtga atagctcaac accaccacgt agaagaacaa
    21361 taccttattc acgaatctac cctccctagt ccttaaaaac aaggctaatc ccctccaaaa
    21421 caaaaaaact gaccgcatcc caaaggacgc aatcagcgtg gttccacctt aatttatgca
    21481 ggacaaaaaa catgccttgc acctctagtg gcgataaggg ggccaccctt ttatgtttgc
    21541 ataaaaacca ggaaggagta tcagattagc tatccttgtg ctctttccac caaccagcac
    21601 tcgcttaaaa gattctgtcc aatctaactt gtcttcaaga taattatagc aagttttcaa
    21661 aaatttacaa gccttaatcc agaaaatctt tgatagcatg gaccagcttg ataggagcct
    21721 tgactacttt tactgaggtg atagctgtga ccttagcagc acgtttaggc aagtgaatag
    21781 caccttgcac taattttaga gaactacttt taccagaatg attaagataa agactcaact
    21841 tttgagcttc tttgctattt ctagcaatta acgtatctaa atagaacgtg taaatagatt
    21901 ttccaaagtg ctgtgctgag atttcataac gtttttttgc taataaccgt ttatccataa
    21961 ctggtgtttt tagtatggca tcaataatag catcagttaa atctgtttca gcgtaataaa
    22021 gagtgccaaa cattttatca gtcaccacat catctaaata aggattgcca tgagcaataa
    22081 taggagtgcc actagccaaa ctttcaatat aggtcaagcc ctgagtctca ctggtcgatg
    22141 ctgagataaa gaaatcacaa gccttatagt acagagcaac cttatcatga ggcaccatgc
    22201 ctgtaaaggt cacgtgtttg tcaacctcta actgcatcgc caagtgtttc aaatcttgca
    22261 aataggggcc atctcctaca ataataagct ttatcttggc attttcagcc aaaatagctg
    22321 gcatctgatt gatgatagct tgaatatttt tttcataaga aatccgtgac aaactcaata
    22381 acatggtttc atcaccagca atgcccaatt ctgcttttaa gttggttact tcttctgctg
    22441 tgatgtcatc acgaatatat ttttccaaag gaatgcctgt tgggataacc cgcttaggga
    22501 tagtcacttc gtaaccttct agaagattga ggacaatcct gcttgggcag ataaccccat
    22561 ccaaatcctt caaatagccc ctaagaagag gtttgaccat acttggtcga atgatttttc
    22621 cgttggcaat ataactcacg tagtcctcat attgggtatg gtaagtatgg acaacaggaa
    22681 ttcgcaaagc tttgcctatc attttcccta ataaacctaa gctaaactca gtttgcgtat
    22741 gaataatatc aagattatag tgttttgcaa ttttgtatga cgaaatgagg ccacgataaa
    22801 ccacacgtct atccgtaaat gacacaaaag gaacacttgg cagtcgaata atggtcgggt
    22861 cttcaaagcg tttgacatct ctatcagtag tggtgaaaat ataaatttcg tgaccttctt
    22921 tttctagctc ttcttttaac gtacgaatac tagtagcgac tcctgaaact tgtggaaaat
    22981 aggtatctgt gaatagacct acacgcatct tataactcca ttactttttt atagacatct
    23041 actaaggcat ggccaaccgt ttctaggcga cgactctggg caaccttgta accagcttca
    23101 actttgttgc tggcaccaga aaagactttt ttcagagctt ctataaaacc tggtatatcg
    23161 gttgctaatt ccgcactact ttgatcaacc catccgtagt aaactggtat atcacgtaaa
    23221 acaaggtgct ggcgactggc caaggcttct aagacaacaa tgccttctgt ttcttcacga
    23281 cttggaaaga aaaaggcatc tgcaccagtc atggcacctt cataaacatc ccctttaatg
    23341 tatcctggga aaataagatt tttcgggtgg ttaccattga ccatttggcg aacttgagca
    23401 ggaatgaccc atttgttggt ctcgccaaac cagataaaac gaacatctgg catagcttgg
    23461 gcaactttga caaagtcatc aattcctttc ctcagaaaaa ataatcctgc tcccataacc
    23521 actttttcgc cctctttaat gtcaaagtag cgacgaaaag ctgcttcctt tttaggatct
    23581 gctccgtact gctccaaatc aatcccattt gacactgcaa aaataggtga cttcactcca
    23641 taactctcaa tcaaagactt agaatatagg gtaggggtaa tgatagcatc tgccttattg
    23701 taaaagtgac aaaggtattt tttaaaccaa ggagataata gatttgaaaa aataaaagaa
    23761 tttctaaaat cttcttctgt agaatgccca tgcatgataa ccttcttacc agctttttgt
    23821 gcttttatca tcagcagcca actttttaaa ccataggtat tgagatgaac caaatcataa
    23881 gtttctcttg gattagtcgt aaaatgttga ccaacaagtg acaaggcttt agcctgatgc
    23941 ttaatcgctc gaccaattcc tgattttctt agataatttt ctgcttctaa atacaataag
    24001 actttcataa gttctattat agctcatttt atagtatttt tcactaagac atgcaaaaat
    24061 cagccctaag gctgatttta gtattgaaga aacagtctat tgtgatactt tttgttagat
    24121 ggtgctcata agtcacagtt acttagttgt cccacgtttt ttaataccat gattcaaaag
    24181 aatttctttt tcttccaact cttctttgtt catgatttta gtcaacatcc gcatgctaac
    24241 agcacctaag tcataaacag gttgactgat agaactcaaa ttgggacgag tgtattgaac
    24301 cactggtgaa tcgttgctgg tgatgatttc aaagtcctct ggtacgcgtt tacctgcttc
    24361 aaacaagccg tttaaaaggc ctgctgccaa ttcatcttca gccacataag ccgctgttgc
    24421 tcctgagtta atgacgcgct gcgccaattc aaatccttct ttataagaat agttcgcttc
    24481 aaaaacaaga ccttctttga agtcaagctt attgtgcttc aacccttctt tgtaccctgc
    24541 taagcgcact ttaccattga tatcatcaat gagtggtcct gacacaaaag cgatacactt
    24601 atgattttca gctaaaatat caacaacgtt tgacaccgca gctctatagt caatgttgac
    24661 gcttggtaat tgatgatcaa gatctacagt tcctgccaaa acaactggag tacgagagcg
    24721 tgaaaattcg gcccggattt tttctgtcaa gtgatgcccc ataaaaataa taccatccac
    24781 ttgcttggca aaaagggtat tgacaacatt aacctccttg tcatcatctt catcactgga
    24841 ggcaagcaca atattatatt tgtacatagc ggcgatatcg tcaataccct tagctaagat
    24901 agaaaaataa ctatttgcaa tatttggaat cacaacgcca acggttgttg tctttttgct
    24961 ggcgagacca cgcgcgacag cattgggacg atagtcaagg cgatcaataa cttctaaaac
    25021 tttcttacgt gtattttcct taacattttt attgccatta acaacacgac taacggttgc
    25081 cattgaaaca ccagcttcac gggcaacatc ataaattgta atggtatcat ctgtattcat
    25141 tttttatctt cctttctatt tgaaaatgac gctttcaaaa agtattttag catgatttgt
    25201 aaccactttc aagtgttata ggttaatttt tgaaaaagtt ttcaaaaatt aactcgaagc
    25261 ttgatttttt aagctttttt tgaaaaaata gtaagtagaa agaaggttag cctatgacaa
    25321 aattagacca aatacgtttg tatcttgacc aaaagggagc tgaattggcg attttctcag
    25381 atcctgttac gattaactat ttaactggat tcttctgtga cccacatgaa agacaactgt
    25441 tcttgtttgt ctaccatgat ttagctcctg tgctttttgt acctgccctt gaggtggcca
    25501 gagctagcca ggccatatca tttcctgtgt ttggttatgt tgattctgaa aatccttggg
    25561 aaaagatcaa ggccgtttta ccaaatacag cagccaaaac catttatgct gaatttgacc
    25621 accttaacgt caataagttc catggcttgc agactatctt ttcagggcaa tttaacaatc
    25681 taacccctta tgtccaaggc atgcgcctcg tcaaatcagc tgatgaaatc aataaaatga
    25741 tgattgccgg gcagttcgct gataaggctg ttcaagttgg ttttgacaat atttccttag
    25801 atgctaccga aacagacgtc atcgctcaaa ttgagtttga aatgaaaaaa caaggcattc
    25861 ataaaatgag ttttgacact atggtcttaa ctggaaataa tgcagccaat ccccatggca
    25921 ttcctggaac aaataacatt gaaaacaatg cccttcttct ctttgactta ggtgttgaga
    25981 ccttaggcta caccagtgat atgaccagaa ctgtggctgt tggtcagcca gaccaattta
    26041 aaatcgatat ctacaatctc tgcctagagg cacaactagc ggctattgac tttatcaaac
    26101 caggtgtaac agctgctcaa gtagatgctg ctgctcgtca agtgattgaa aaggctggat
    26161 atggtgagta cttcaaccac cgcttgggac atggtatcgg catggatgtc cacgaatttc
    26221 cctccatcat ggctggcaat gacttggtcc ttgaagaagg tatgtgcttc tctgtggaac
    26281 caggcattta cattccaggt aaagttggtg tgcgcatcga agactgtggc catgtcacta
    26341 aaaatggctt tgaagtcttt acctatactc caaaagagtt gctttatttt gaaggctaag
    26401 cccctaccat ctggttaaac aaaccctcgc gaaaggaagg tattcgtatg gatcaaacca
    26461 ttcatcacca aatacagcaa gcactacact ttaggacagc cgttcgtgtt tataaggaag
    26521 aaaagatttc tgatgaggat ttagccctta tccttgatgc tgcttggtta agcccttctt
    26581 ctgttggctt agaaggctgg cgctttgtcg ttttagacaa caagcctatt aaagaagaaa
    26641 tcaagccctt tgcctggggg gcccagtatc aactggagac agctagtcac tttattcttt
    26701 taatagccga aaaacatgca agatacgata gccctgctat caaaaatagc cttttacgac
    26761 gtggtatcaa agaaggtgat ggtctcaaca gccgcctaaa actctatgaa tctttccaaa
    26821 aagaggacat ggatatggca gataatcctc gggcactctt tgattggaca gctaaacaaa
    26881 cctatatcgc tcttggtaat atgatgatga cagctgctct tttgggcatt gatacttgcc
    26941 ctattgaagg ctttcattat gataaggtca atcatatcct agctaagcat aatgtgattg
    27001 atttagaaaa agaaggcatt gctagcatgt tatccctagg ctatcgtttg cgagatccca
    27061 aacatgctca agttcgtaag cctaaagaag aagtgatttc agtcgttaaa taaggagatt
    27121 aaaatgaaag cattacatac ctgtatccgc gtcaaagacc ttgaccagtc ggtagctttt
    27181 tacacaagcg ccttcccttt taaggaaaac tatcgtaaag attttccaga tagtcaattt
    27241 actcttgttt atctggcttt agaaggagaa agttatgaat tagaattaac ctacaattat
    27301 ggtcatggcg actacgactt aggaaatggc tatggtcata ttgcccttgg ctctgaacat
    27361 tttgaagcag accataaaaa acatcgacaa gcaggttttc cagttaccga tatcaaagaa
    27421 ctggctgaca aatctgcccg ctattatttc attcaggatc cagatggcta caaaattgaa
    27481 gtcattgatt taaacaacta atactattaa caacagaagc tttaaagctt ctgttgtttt
    27541 attttttaac ctgacgattg ggataatctc attattaaca gagttttgaa atatctcagc
    27601 ttttgtgtta caattgccct aaaattccat ttgaaagaaa agtctatgac actactatct
    27661 atcattgtcc cctgctttaa tgaagaagca aacattctcc cttattttga agaaatgcat
    27721 caactagaaa cgtccatgtc caaccaactt gcttttgaat acatttttat tgatgatggt
    27781 tctaaggata acaccttagg tattttgcgt gagctagctg ctcgctttcc aaacgtgcat
    27841 tatctgtctt tttcacgcca ttttggcaag gaagctggac tcttagctgg actaaaagaa
    27901 gccaaaggca attacattac tgtgatggat gtggatctgc aagatccacc cgaacttttg
    27961 ccagttatgt acgctaagct aaaagaaggt tatgacatcg ttggcaccag gcgccaaaat
    28021 agacaaggag aaccactaat tcgttcaatg tgttcgaatc tattttatgg actgatcaaa
    28081 cacttatcag atactgaaat ggtcaatgga gttcgggatt atcggttaat gaccagacaa
    28141 gtcgttgata gcattcttga gttgggagag gttaatcgtt tttcaaaagg gatcttttcg
    28201 tgggttggtt atcgtatcac ctatcttagt tttgaaaatc aaaaacgcaa atatggaaaa
    28261 agtcgttggc atttttggga gttgctccga tattctttag atggctttat caacttttca
    28321 gaaatgccgt taaccattgc tacctggaca gggactttca gctttttgat ttctattttc
    28381 gccatcttat ttatcattat cagaaagata ctctttggtg atcctgtctc tggttgggcc
    28441 agcactgtct ctattatttt attcatggga ggcattcagc tcttttgcat gggtattatt
    28501 ggaaaatata tttcaaaaat attccttgaa actaaaaaaa ggcctctcta tattatcaaa
    28561 gaaaaacatt aaattaaaac atttttctca tcaatcgttt cctactcctt ctgtgcgcga
    28621 agctttcttt ttaagcccgt tataccaaat gataatgacc tttccaaaat agtatcacct
    28681 tccttaacac tttaagtaga aaaggaacta ttaggttgag cctttttgca aatcctagcg
    28741 actaatgtta taatcgtcat actattgaaa aaggagttct ttatggagtg gattaaatta
    28801 atcggtattg tgattatcgt attagggttt attttaaaat ttgatgctat cgctaccgta
    28861 gttgttgcag gacttgttac cgcgctggtt tcaggaattt cgtttattga ttttctagat
    28921 attttaggaa aagaatttac caatcaacgt ttgctaacca ttttcttcat cactttaccg
    28981 cttatcggct tgtcagaaac ttatggactg aaacaccgag ctactcagtt gattcaacgt
    29041 gttcaagccc ttaccgtcgg ccgtttattg actctctacc ttattattcg agaattagca
    29101 ggtctctttt cgattcgact agggggacat ccacagttcg ttcgcccctt gattcaacct
    29161 atgggagaag ctgctgctaa agccaacatt ggagaagagt tgaccgatgc agaaaaagat
    29221 gatatcaaag ctatggcagc tgccaatgaa aactttggca atttctttgc ccaaaatacc
    29281 tttgttggcg caggaggtgt cctacttatc gctggaactt tagaacagct tggctatgat
    29341 ggtaaccaag ctaaaattgc attttcttct attttaattg ctattatctc tattattata
    29401 gttgctattt acaattacct ctttgagaaa aaaatggaac gtcaacatca gaaaggagat
    29461 aactaatggc taacattgca aaccttgttt tagaaacgat atatatcctt atcggcttgc
    29521 aactgtttca cacagcctac tgcaccttta aagataaaac caaccctgtc tattttggga
    29581 cagctctgtt ctggggattg ctgggtgtta ccttcgttgg cggtgccttt ttgcctaaca
    29641 aagttatcgg ttttatcgtg attgtcctag ctcttttaac cttgtttaag caagttcgta
    29701 ttggaacatt accagtcttt aatgaacgaa aagctgaaga aagtgctcac cgcattggta
    29761 actggatttt cttaccagtt atgttaatgg ctatgatttc tctacttctt gccttgatcc
    29821 ttcctgattt cagtaaaagt gccattggga ttgctggtat cttagccact attgctattt
    29881 taataatcac taagcaaaaa ccatctgctc ttttagctga aaataatcgg atgaaccaac
    29941 aagtgtccac aagcggtatt ttgccacagc tcttaggagc tttaggagct atttttgcag
    30001 ctgctggtgt tggtgatgtg attgcttctc tcattcggga gattgtacct gctgatagcc
    30061 gcttctttgg tgttctcgct tatgtgcttg gcatggttat ttttactatg attatgggaa
    30121 acgcttttgc tgcctttacc gttattacaa ccggtatcgg tgttcctttt gtttttgctt
    30181 taggagctga ccctattatt gccggtgctt tagctatgac tgctggtttt tgtggtacct
    30241 tattaacacc aatggcagca aactttaatg ccttgcctgt tgctttgatg gagatcaaag
    30301 atcgaaatgc agttatcaaa aagcaagctc ctatcgccct tgttttaatt attagtcaca
    30361 ttgccttaat gtatttactt gcttattatt aacttttttg ctaagttagt agcgtcagtt
    30421 attcattgaa aggacattat tatgaaaatt cttataacag gctttgatcc ctttggcggc
    30481 gaagctatta atcctgccct tgaagctatc aagaaattgc cagcaactat tcatggagca
    30541 gaaatcaaat gtattgaagt tccaacggtt tttcaaaaat ctgccgatgt gctccagcag
    30601 catatcgaaa gctttcaacc tgatgcagtc ctttgtattg ggcaagctgg tggccggact
    30661 ggactaacgc cagaacgcgt tgccattaat caagacgatg ctcgcattcc tgataacgaa
    30721 gggaatcagc ctattgatac acctattcgt gcagatggta aagcagctta tttttcaacc
    30781 ttgccaatca aagcgatggt tgctgccatt catcaggctg ggcttcctgc ttctgtttct
    30841 aatacagctg gtacctttgt ttgcaatcat ttgatgtatc aagcccttta cttagtggat
    30901 aaatattgtc caaatgccaa agctgggttt atgcatattc cctttatgat ggaacaggtt
    30961 gttgataaac ctaatacagc tgccatgaac ctcgatgata ttacaagagg aattgaggct
    31021 gctatttttg ccattgtcga tttcaaagat cgttccgatt taaaacgtgt agggggcgct
    31081 actcactgac tgtgacgcta ctaaacctat taaaaaaaca gagatatgaa ctaactctgt
    31141 tttttttgtg ctaaaaatga aagacctagg gaaacttttc ataggtcttt ctcaattgtc
    31201 atcttaatct aatactactt ctaacatcag cgggtatagt ttaccagtaa ttaagaaacg
    31261 ttgttgatct aaatgagcaa tcccattcaa aacattaagg tcagggtaat gggacttatc
    31321 aagatttaag gcttttaaca aaggactaat atcataggtg gctaccacct ttccagaatc
    31381 aggttggagt ttgacaatag tattggtttg ccaaatattg gcatagagat aaccatctac
    31441 atactctaat tcgttaagca ttgagatggg gacactttct atagcaacta gtacggtatc
    31501 caataaagca aaatctttgg ggtctcgctt ttgcaaaaaa gcatttccac tagtcatcca
    31561 aagacactgg ttttccttat cataggctaa tccccagcca tctccttcaa atggataggc
    31621 ccctaaacaa ttgcaggtag tcttatcaaa cttgtaggct acaccctctt tataggttag
    31681 taaccaaaaa taatcctcaa caactgttag cccttctgca aaaactgtat ctggaaaagc
    31741 tattttttct gaaaagatct cttgagtaag gtcgtacacc cctacttttg agaaaccata
    31801 acgaccggca ctaagtaata tatgattgtt gttgagttgt tctaatccct gcgtgtataa
    31861 gttgctatca taagaataag ttcgtaacaa acgaacctgt cctttagtta tcataatact
    31921 cgttcacctt accttgcatt gtagtgtttc atttgttttt taatatctct ttcctgatca
    31981 cggcgtttaa tggtttcgcg tttgtcataa tcgtgtttcc ctttagctag accaatcaga
    32041 actttagcaa agccatcctt gaggtaaact ttgagaggaa ccaaagtcat gccagttcct
    32101 ttgagttcat ttgctagatg cgtaatctca cgttttttga gcagcagttt gcgggttcgt
    32161 tcaggatcag cgttccaaat attaccttgt tcaaaaggtg caatatgcac gttgaccaac
    32221 cacgcttccc cattcttaat ttgggcaaag ccatctttca gttgaatacg agctgcacga
    32281 acacttttaa tctcagttcc cgttaagaca atccctgctt caacggtttc aacaatgtga
    32341 taatcatgtc tagccttttt attttgcgcc agtatatgac cttcaccttt tgccatagtt
    32401 aactcctttt acgactcttc ttttttgctt gttctttgta aaatggtttt ttagaccctt
    32461 ttttagtttt acccttggtt tttgccttgg ctacttcttt aggttctttt ttctttgtcc
    32521 ctttagatga ttttgaggat ttacggcgat ctcgtcgact agctttatcc gacatcttga
    32581 ttttttcaac cacatcaaag tcgctaggta aatactcaaa gtcaatgtca ccagtttcct
    32641 tgtcagcctt aaccaatttc acacgaatag gttgaccgac cttaaagacc ttacctgatt
    32701 tttcaccttg aaggcttagc gttctttcat taaagtgata gtattccggt aagctagtga
    32761 tatgaaccaa accttcaatc gtatttggca attctacaaa aaaaccaaat ttaacgacac
    32821 tggccacgat accgtcaaat tcttcaccca catactctgc catatactca gcttttttca
    32881 tggcttccac cacgcgttca gcatcaatag cacgacgctc taactgtgaa gaagatgttg
    32941 ccagctctgg aatgatctga gcaaaatggt cgcgcttttc ttgactaggt tgattgtact
    33001 cacgaaccat gcggtgaacc aataagtcag ggtaacgacg aatcggactg gtaaagtgag
    33061 tgtaatattc tgcggccaaa ccgtaatggc catgattatg ttctgaatat cttgcctgtt
    33121 gcatagagcg tagaagcatc atgttgagca cttctgctcc tggttgacct tcgacttttg
    33181 ccataaaggc ttgcaaggct tcctgagaaa tcttgttggc tgttccttga atgtgaatac
    33241 caaaggtgct agcgtaatca ataaattgtt gaagtttttc aacctttggt tcttcgtgaa
    33301 tacggtagat aaacggtaac ttagcttttg caaaatgttc tgccacacac tcattggctg
    33361 ctagcataaa ggattcaatc atccgctctg caatgcccct ttgacgaagc accacatcaa
    33421 ccggcattcc tttgtcattg acaataattt ttgcttcttg cgtatcaaaa ttcaaggcgc
    33481 ctcgttttga ccgcatagct tccaagatcc tatgtaaggt taccataagg gtcacatcat
    33541 cagcaatgct agcgaattct tggagcgctt cttcatctcc tgcaatcatg tcattgaccg
    33601 tactatacgt cattcggtaa gttgtcttaa tcactgattg acagatttga taattgacca
    33661 catgcccttg agaattaatt tccatcaagg ctgactgggt caaacgatca acgttagggt
    33721 tcaaagagca gatgccattt gacaaacgct ctggtaacat cggaaccaca cgatcggtga
    33781 catagacaga agtgccacgg gcgatagctt ccttatcaag ggcagatcct tctgtcacat
    33841 aatatgagac atccgcaata tgtaccccaa gttcataatt cccgttatcc aatagcttaa
    33901 tatggatagc atcatctaag tctttggcgt ccgcaccatc aatagtaatg gtggtttctt
    33961 gacgcaaatc cacacggcct attaaatctt tagcagttgg tgcttctgaa atagcattgg
    34021 cctcagctaa aacttctgct ggaaattctg acacgatatc catcgattca aggacttcta
    34081 ggacatcaat tccaacgtct ccttgatggc ctacgatatc acgcacactg gctacaaaat
    34141 aatcgtgccc gcgtgtgggg tatttatcaa tatcaacctt gatgatttca gtgcctttaa
    34201 gcacaacagg ttcttttttg atatagattt tttgttgaat cttttggttt ttggacctga
    34261 tataaccagc atattttggt ttgtcatcat ctaaaataaa ggttccaaca gctgttttta
    34321 aagaacggtc aacaatagca acgaccttag cttcagccgc tgtgcctttg agacggtctg
    34381 ctggcttttt aaccactact tcgacagtat caccatcaat agcataccca acatcattac
    34441 gaccgataaa catatcgtct tcattctcat ccacatgtaa gaaaccaaag cctgctttat
    34501 tggcacgaaa aacaccctga acagtaggtt cttttttctt ttcacgctct tttctaagag
    34561 ccagactgcc atcatctgaa aaccgtaaaa ggctctgact ttccattttg gaaatggttt
    34621 taataaggct gggaaaatgc ttagctccag ccatctccaa ggccgcagcc aagtcgttca
    34681 cattggactt gccatgctcc ttgaggtaag tcataattct ttctttcatc atacctaatt
    34741 tctatttctg ttttgtttgt tggaggatat caatccgttt cgctgataaa aaaatgagct
    34801 agactaactc tgtcaagctc actccttatt tacttgataa aatggcaagc acaagtgcaa
    34861 tcgctagcca aaaaaatact agaactgctg tgaatcgttg catgaatgct tcaaagccac
    34921 gagcttttgt acgttcaaac aaggcttctg aaccgctgct atcaaaaaca ttgctacttg
    34981 ggtttttttg aggttgcata aaaatagcaa tcacaagcaa taccgacagt actagcaata
    35041 tcgtaagtag taagttgtac atgttatttc ctccactatt gtcatgacca ttctaacaca
    35101 attcttatca agtttcaaca tgcagggtca cttttctctc cttggggcag tatttgggaa
    35161 cttttatttt ttccggatga ctgcttttat ttttactggt tagataattg ttactgccac
    35221 actcactaca ttctaaatta atttttactc tcacacaata tccttaactt taatatattt
    35281 tcgaaatata atcaaactcc atattaaatt aacaaacaca atcaaactag tcacataaaa
    35341 aacagaacgg tagcctaaca ctacagccac atttgatccg ataaaagggc caatgacttg
    35401 accaaggtta ctagacattt gattataggc aaatactcta gaaatacctt cttttggtgt
    35461 taacttagtt agtaaagagt taatacttgg catcaaagcg cccacaccaa acccataagc
    35521 aaagcgtagt actcctaatt gaaaactggt ctgcgctaag gcactgctaa aatacatgat
    35581 aaagctataa cacaaagcgg ctaacaataa ccgatgattg ccaaaacgat ctcctaattt
    35641 tcctaagtaa gaactgctaa ataagctaga aaaccccatg gccgaaacta ccaggcctga
    35701 agtaaacatt aagttgtgag tttgaccaag atgacgaata tacaatgata aaatgggggc
    35761 cactgattga gctgaaattt gaataatcat actagtcaca aacaaaccaa gcataatctg
    35821 gggacttttt acctgtttta aaatgacttt tgtaggtatc atctcaaagc gcctaatcgg
    35881 cttaaactct tctttaacat aaacagctgt cattaaagaa cataaaaata atatcacacc
    35941 aactaataag aaaacttgtc gaattcctaa tagctctgcc aaaatccccc ctagtaaagg
    36001 accaattaaa gcgcctgctg tcactcctgt tgctaatgtg cctaaagcat aacctgactc
    36061 ctcttttggg gcttggctgg caatcaaggc agtggcattt ggcacatagc ccgcaaagac
    36121 acctgttaat aatctcaaaa tgagtaacca aaacacatta ggaataatag ctaaaccacc
    36181 catggtaaag gtcatgacaa aactggctcg cagcatcata ggttttcggc cataacgatc
    36241 agccaacttc ccccaaacag gagcaaataa agctgaagca agtgccgtca cagcaaccgc
    36301 cagaccagca tagtattcta ctaattctgt cggagtacct aaattttcca catatagagc
    36361 cataaaaggc ataacaagtg aaaagcttgc cccagtaaag aagttaccaa gccaagccac
    36421 ttttagattt tgtcgccagt tcactgtcgt taccgcttta tcactaatag atcatcatct
    36481 tctttccatt gggcctttga ttattataac acatttctgc caaaaacagt gtcccataat
    36541 agtgctaagt ctcatctgat agccttcatc gtttacgtaa actacccagt aaacctctga
    36601 ccagttctcg cccaattgtt ctaaccgtcg tactaataaa cgcatctgtt gctttttcga
    36661 cgactgtttt tcgtggacgc ccaacagaac gccgattagc ttttttggta gctgcttgcg
    36721 ccttgatggc ttctttagct tctttttcgc gttgtgctgt cgctatcgct tcttgggcca
    36781 gtcggttgtc ttctaaaacc ttagcagcta atttttcata agcagattca cggtcaatgg
    36841 actgactata tttactggca aaaggtgagg actgcacaag ctgctgactc tctatctctg
    36901 acaaaacagc aaagctactc ttaggcggca tgatataggc acgttcaacg atggatggtt
    36961 gtcccttatc attcaaaaca gaaatcaagg cctcaccgac ttctagttct gtaatcaccc
    37021 ttgccacatc taagtcagga ttttgtcgga aagtatccgc agcgacacga accgcctttt
    37081 gttctttcgg tgtataagcg cgcaaggcat gctgaatacg atttccaagc tgagccaaaa
    37141 ccgtttctgg caaatcaagt gggctttgag tcacaaagaa aatcccaact ccctttgaac
    37201 gaataagtcg cacaatctgt tcaacttttt ccaagaaaac tttaggggca tctttgaaga
    37261 gcaagtgagc ttcatcaaaa aagaaaacca tcttaggttt gtccaaatcc ccaacttctg
    37321 gcaataattc gtacaactca gacaagagcc aaagtaagaa ggttgtgtaa agggtaggag
    37381 attgaaaaag cttagtcgct gacaaaatgt taatggctcc atagcccgaa gcaacatcta
    37441 attgcatcaa atcagccaca tctaaagcag gctctccaaa aaattggtgg gctccttctt
    37501 gttctaatgt caagagactt ctttggatag ccccgataga ttgcttggcg atattaccgt
    37561 aatggctgga gtagtctgag gcatggtcac caacttcttt taagatagcc tgcaagtctt
    37621 tcaaatcaat caaaagccag cctttctcgt cggcgatttt aaagacgatg tttaagatac
    37681 ctgtctgggt atcattaaga ttcaataaac gcgacaacat catcggtccc atttcagaaa
    37741 tcgttgtccg taagggttga ccgttttgac caaaaacatc ccacattctt acaggaaagg
    37801 cctgaggctg gtaatcactt accccgattg tggctagacg cgcagccaat ttatcagtca
    37861 cctctcctgc tttagtaaga ttagacaggt ctcctttgat atctgccaaa aagactggca
    37921 caccagctaa acttaattgc tctgctagca cttttaaggt cacagtttta cctgttccag
    37981 tcgctccagc aatcaaaccg tgacgattta gcatccctaa ttgtaaggct atcggttgat
    38041 tgccttttgc aattgtcatt gtagtcatag gcttcctctt ttttgatgat catacttgtc
    38101 gatatgtgtt tacccataag ttaaagtgtt tagaagggtc tcgctcttaa tactattata
    38161 acatataacc cttgatgcgc taatttaaaa gggaccagct agttttagac agaaatagct
    38221 tgattttgac agctatgata cgaatctctc agcttagcta cctcggattg gctaatgaca
    38281 acaacgcaga ttgtacttgc tttattaacg tttccatgtc tccattatta tcaatcacta
    38341 gactggcata gggctttttt tcctctattg gtaactgact ggctattcgc tgccttgctt
    38401 ttcctttgtc taaacgattt ctagccatta agcgctgcaa ttgtgtctga gcatctacat
    38461 aaaccagcca aatcgcatca aaccagtctt ggtagcccaa ttccattaaa aggggaatat
    38521 ccatgaaaaa aatggcttgg ctctgtgcta agtggtcacg cttagccgcc aattcttcct
    38581 taatgatttg attttgaatg gctgaggatg ttgccatatt atctgggttt gaaaaaagca
    38641 tttctgacag ctttgtgcga tctaactcac catctgcttt taaaatctga ttcccaaaag
    38701 cttctctaag agcctcgtaa aggcgaccgc ctttttcttg caagtcatgg accacttgat
    38761 ccgcatcaat cacctgataa ccagcttttc taatgacctt aaccacagtc gattttcctg
    38821 atgcaatgcc tcctgtgatg ccaataatca tggtcttttt ttctggcatt ttggacaaat
    38881 gtgcgtcccc cttcctccaa cttttaattt gacaatagcc tgtccacaac gaggacacgg
    38941 tttcccagtt tgaccataaa cctgcaaata gtcctgcatg gtgccatcag ctcccaaagc
    39001 attacggtaa gtacggacgg tcgaaccgcc cttttcaatt cctaaagcta ggattcgtat
    39061 ggtttcatca tgcagccgtt ttatctccgc cttattcaac ctagaagacg cagtttctgg
    39121 atgaacctta gcagcccaaa gtacctcgtc cacataaata ttccctaaac cagcaaccaa
    39181 ggtctggtct aacagatgtg gttttatggg tttttgggag gatagcagag cagtctcaaa
    39241 ggtttttaac ttaaaggtct ctttctttgg ttcagggcct agttttcgtt tggcaaaaaa
    39301 cgctgataat tgagattttg ctatcaaatc aaaggttcca aatttacgca catcttggta
    39361 aaccaaggtc gaaccatttt tcaattcaaa aaagacatga aagtgtttgt tatcagggac
    39421 ctcatctgga aaaagcaaat atttgccttc catccgcaaa tgtgatacca acactaattg
    39481 ccccaaatca attaataaat attttccccg acggccaact gactgaatga tttgaccagg
    39541 tagggtcagg gcaaacgtct ctaagtcggt tttaaccatt tttggcactt taagcgtaac
    39601 agccacaatt tcttggccaa gcactaaagc ctcaagccct cgtcggaccg tttcaacttc
    39661 tggtaattct ggcataatcc gttatttaaa ggacagctag accctttgct gctacaaaga
    39721 ataaactcag cataaaaaag tcactcaata gactcaggtc taggatactg actgcgtttc
    39781 aaaaaacaca gctgtccttc tcctttctta tttcttattt tacgaacaca tctgatagaa
    39841 agcaactcat aaatctgcct cagaccagtc ctcatccccc ttacctccca gcactatttg
    39901 gcggtaatgt tccttataac tataatacaa tgagtcctct ccaagatact taaaaatctg
    39961 caaggcctgc cgcatgtcct cttctccaga aatttctttc tgctttaatt tataataccc
    40021 atgcacatat aagaaaacag tcttttcata aaaattgagc tcgtctcgca gcaaaagatc
    40081 aattttgtta atcaaatagc gactatgttc aaagcaagaa tggtcaatac tgataatgag
    40141 acaattaatg gataactgag tcactaacat tttattggtt ttattttgtt ccgaataagc
    40201 aaaagatgct accatttcct tagtcaataa aaatagggta ttgtaattca tgaagcgcga
    40261 gcaattcccc agaagaatga tttcataata tccccactgt tccactttaa ataaataatc
    40321 tgtgaggcga gtcaattctt cttgactagg tgcaattgag gagtcaatag aaaaaagaat
    40381 agctttaatc atcgttcgtt cataatcttt atgggcataa tccttcaaca gtttggtcaa
    40441 tttaaccacg tttttctcag cataacattt tctcgcctga cttaagagcg tgaaaaaatg
    40501 cgtatgcgtc ttggaatgag ccgaaacaaa ttcgtcaatc gtaatattca gtttatccaa
    40561 aagattaagc aagcgactgc aggtgatttc tgattcccct cgttcaaatc ttgaaatttg
    40621 tgacttggac aggtattcat ctgctaaaaa agaaatgcta acctgcttac ccttacgtaa
    40681 tcgccttaag gtttttccga gttctttttc catttttccc actttcacaa caaaaaatta
    40741 aaatctgcta aatccattat ataatacaag tacaaaatag aaaatcagaa aggagacagt
    40801 catgaaaaaa gttaataaag ctttgctttt tacattgatc atggatatcc tgattatcgt
    40861 tggtggataa cctttcgctt aaaaacaatc cacttttggg aaacccttat atttagtttg
    40921 taacaggaaa actaataaat attaaaaaga gtgttagcga cctagcggca gctttactct
    40981 taagtgcgtt tgctgccatt gacagcaagg tcaaagctga tgaaacagca ggggcatacc
    41041 gttatgatgt gtctgaacaa aacacttact atcaaactat cagctccatt aaccagcaac
    41101 gacctggtgc cactctcgac gaatgaggtg attattatgg aacccttact tcatttactt
    41161 cccaaagtcg taccagtact tatacacttg gtagacaaag ccaacgtatc atggttaaca
    41221 gtgatattac agttacctat actcttaaag acaatttggt agcccttcat aaggaatata
    41281 aaacctttgt caaaaaaata ttacagataa accgatcacc agtgactacg acaaggctaa
    41341 ggttatttat aaccatttaa tcaacgaata cacttacgcc acaaaataac ttagcaccaa
    41401 tcgcaaaatc gtaagcagca tcaacaatca tactcctaaa gctctttatc gtggcaagtg
    41461 tggtgtttgt caagcttatg ccgtcatgtt taaagatatg gcagaagctg caggcttatc
    41521 agcttggtat gtgataaaaa aggattgaat gagcaccatg cttgaaacat cgttaccatt
    41581 catggtgtta attcctacgt tgatgctacc tggaatgatt cagcatacac cacaaggtat
    41641 ttccttgctg gaaaagacgt gaggaatact gagtaccgtt tagatagcca gtacaaccac
    41701 ttggctaatg ctattttaac taccagctac caaaaaggct aaactaacaa caactacatt
    41761 tttcaactag aaaggcctaa acaatgacca aaaaacagtt ttatcttatc ttagctatta
    41821 gcatactgtg ttttattctt gccgtcagcc ctaaaccacc aattcctaaa cacactattg
    41881 aaaggaaaag gactgcgatg accataggcc actcaaaaca aaaccctcac aaaaaagaag
    41941 cccttaaaca caaaaaaaac aaaaataaga ctctttttct tccaagtggg gacagcgcta
    42001 tcaaatctgt tattagcatg acagttagac tcctgttaga tgaccaatct tagctctcct
    42061 aaaatcagtg gacactaccg tttcggtagt gttctttttt aagctaatct catcaccacg
    42121 ctttcttcaa gctaaaaaac tgatcatgaa agagcaaccc caccacccta acagcccact
    42181 ttgcccgcac tttcttaaaa agttaggaga aaacgatata ccaattattt tctgatccca
    42241 gctccctatc attaacaaga tgtgtagcac ggacctacat acaggtaagc tagagtcatt
    42301 ctcgctattt cggacaaaaa gaggccggta gttccctgac ctcttcttta tttatcttgt
    42361 aacactcctc ttcttagcga gacttactag cacataattc ttaagcactc ttatcattta
    42421 gactaggaag aataccatct gaatgaagca aatgatgcgt cagatctgcc agagtatcat
    42481 ctccataagt aatccctgtt tggtgctgtt tctgatgaaa atcagatgac tccttaactt
    42541 tagcagtcac ctgctggtca cttggatgaa aattaatttc tctcttggct tcagccgcaa
    42601 ctggctcgag gaacaactta ttgacattac ggtcttcctc caaatgatta aggatagcag
    42661 catcatcttc taacgaaaga accttcttgg gtaacaaaaa ggggttattt agccttggct
    42721 cagtaacgac ttccttggct gctcgtgata gtttattatt gtcttcctca ggtatcaaac
    42781 gattaagcaa tcgatgcaat tcttccggct atgaggcgct cacagctact tcagaagaaa
    42841 cctccaagcc ctttcctgtt tgcctgtcta aagcaaccgg caaattatta actaactttt
    42901 taacctgtcc tcagcgctca tttcaacact aggaagagct gtcgctggtt ctagccagct
    42961 accaacttct gctggtctta ccttaacatc gctggcaggc ttctccttct catcttcatt
    43021 aggtctaaaa ggctcaaacc gccctgttga tttttcatct atgaccttta tattgtcttt
    43081 tactacatga gacagtggtt cgacatttac catagcttca tgctcgttaa ggctctggtc
    43141 tcgtttgaat ttaccaggaa taccaggagt cggtgttcca acagattgat cggtttcagt
    43201 aggctctttt acggagcctt ttttccataa aactgctgga ggaataatat ccgtagagcc
    43261 atccccataa gtaatcgtgg cctgcctccc ctttggatta atagatactt taatattgtc
    43321 tgggaaagcc ccactacctc ctgtggttaa aagggcaccc gcatttttaa tgagagttgt
    43381 cattcgttca ataccagcaa cgccaatatg gttcaagtca tctactggta actgatcaac
    43441 agatttcatg gtgtatttcc aagcttgcgg ttgaacaaga aaaacagttc ctttatacat
    43501 tgtgttatac atatcatcaa tgactttgaa ataccttgta tatttggttt gtacattagg
    43561 gttagcaacg ggaacagtgc tttcaggaac tcctgacatc gtaaaaatcc ctctagcaga
    43621 agtttgaaag ccctcataaa catgacccat accaggaaca gtctgagcgg tcaaagactt
    43681 accagaacca tccaaagcaa tgcgaatatc tttcatcaga tacatctgat tggtgtaggt
    43741 aaacctaacc gtgttagcct cacctcgata caaaaccact tgggagggct gatccgaaga
    43801 aaactgagag gttgtttctt ccttatagcc aactccaaaa cgtctatcag acgaatggac
    43861 tgaatctgcc gcaactgtac tactcaaact gactagtaaa gtagccgcac aaccaactaa
    43921 taaactgctc attttaactt taacatctct taacatcatc atgttccttt cattattttt
    43981 tatttaggaa ttcgtcatac tatattttct catattagtc taacaaaaaa accgtaattc
    44041 tatataaatc atataaaatg acgagctttg gcaaagatga gtatagcagg atggaaaaca
    44101 gattgtttct gaaacttcaa aggtatcttc ttgtcacgaa ctattcttta attga
//
LOCUS       DAUDWO010000014        42419 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.014, whole genome shotgun sequence.
ACCESSION   DAUDWO010000014 DAUDWO010000000
VERSION     DAUDWO010000014.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 42419)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 42419)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..42419
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.014"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            168..329
                     /gene="sagA"
                     /locus_tag="VHC05_000698"
     CDS             168..329
                     /gene="sagA"
                     /locus_tag="VHC05_000698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TOMM family cytolysin streptolysin S"
                     /protein_id="HEQ5402028.1"
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQG
                     GSGSYTPGK"
     gene            551..1501
                     /gene="sagB"
                     /locus_tag="VHC05_000699"
     CDS             551..1501
                     /gene="sagB"
                     /locus_tag="VHC05_000699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="streptolysin S biosynthesis dehydrogenase SagB"
                     /protein_id="HEQ5402029.1"
                     /translation="MSFFTKEQQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVL
                     KTSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVY
                     ESQEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASI
                     RDGASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSEEN
                     VRDFAEYGAINAENCNIIIIYVYHYMKNTRKYGNQATAYAFIESGEIAQNIQLTATAL
                     TYGSIDIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     gene            1498..2556
                     /locus_tag="VHC05_000700"
     CDS             1498..2556
                     /locus_tag="VHC05_000700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="streptolysin associated protein SagC"
                     /protein_id="HEQ5402030.1"
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIV
                     YQEIVSQLVKGVAIDTETYENALEPETFANLMEVISGLCYNDMLMLEDDYNLEENVMK
                     ILMGNFRFMAQAGHMVSNDPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQ
                     TDVSSRLDALEHRRNMNCLSEALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIG
                     FVDGPFLHTCTLNPPHSADFDSLERRVLARLQDSTLYQHFANQILPATQDVSQAYLPL
                     LNVLMNLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLK
                     YEDQQISTREIVKKLLDE"
     gene            2576..3934
                     /locus_tag="VHC05_000701"
     CDS             2576..3934
                     /locus_tag="VHC05_000701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YcaO-like family protein"
                     /protein_id="HEQ5402031.1"
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKS
                     ITGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRI
                     VYASYNELKLLHKVMPLEYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFF
                     EDAEMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEYIQIDSM
                     MLSWYTKKPCPKIIVDDPDIEVILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILK
                     NKYDEGPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLF
                     LDLDSNVFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKV
                     SPNAVFLDITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHP
                     MP"
     gene            3909..4580
                     /locus_tag="VHC05_000702"
     CDS             3909..4580
                     /locus_tag="VHC05_000702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEQ5402032.1"
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYAFNLIGFLRA
                     TLIYDILALVSIYVLSPQITLSFESIDSKTFFMGLVFCVLIVLIELVFLHGLRCWQKK
                     QWLPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWHLPTIIVLIVTSF
                     CYALNHLLMGKSIFYAKLVTGIIYSSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKK
                     KKEVT"
     gene            4577..5260
                     /locus_tag="VHC05_000703"
     CDS             4577..5260
                     /locus_tag="VHC05_000703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="streptolysin associated protein SagF"
                     /protein_id="HEQ5402033.1"
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLVALSYQDFLDV
                     LLSLFQFVIIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIEMTLLVL
                     ILIFDVLLQKDSRLLFKKITWLPFRQDKPVLSILLLGIAILVDSLFYLGLLILLGEQS
                     LTSLATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGAMILMVT
                     YLMISCKEY"
     gene            5283..6206
                     /locus_tag="VHC05_000704"
     CDS             5283..6206
                     /locus_tag="VHC05_000704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402034.1"
                     /translation="MSFVQLTNVVKSYKNGKKAVNDVSLSIEAGNIYGLLGPNGAGKS
                     TLINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGS
                     LYGLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDE
                     PTVGIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPK
                     FELEKRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQL
                     TQANITFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            6215..7342
                     /locus_tag="VHC05_000705"
     CDS             6215..7342
                     /locus_tag="VHC05_000705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402035.1"
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFN
                     TATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLEAKPSNSLEKDRQRVSEGAL
                     TAVLEVKKNQTIKVITNNINQQNADLINMLVKNYVDNAKTYDSIAALYPQQLNHIRKR
                     SVDYVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRITNRIRLTG
                     VSPSLLVFGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLIGITASLVYLSVAI
                     GIGLGISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDS
                     LFYLIFGGQYNPIPVTLIVNISIGTIFIILALIGMRKQVTT"
     gene            7339..8457
                     /locus_tag="VHC05_000706"
     CDS             7339..8457
                     /locus_tag="VHC05_000706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402036.1"
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQA
                     KIGILDKDNSQISKQFIAQLKQNKKYDIFTKIKKEHIDHYLQDKSLEAVLTIDKGFSD
                     KVLQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQ
                     LNYDVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSN
                     LSRFRYMLSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLIIFFLFSLLAIGFG
                     LLIGAITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIA
                     IFQSGGTLSQAWPHLLALMGTALALIIFSSLLLKPTRL"
     gene            9029..11761
                     /locus_tag="VHC05_000707"
     CDS             9029..11761
                     /locus_tag="VHC05_000707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SpnA family nuclease"
                     /protein_id="HEQ5402037.1"
                     /translation="MINKKYIIPVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKR
                     ESVISDKSNFPVISPYLASVDFGERKTPLPTPDKGVKVTTEQSIAQVRKGPEERTYTV
                     TGKITSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSKGDIVQLTGTLTRFKGDLQLQ
                     QVTAHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNNTSFLVRDD
                     SGKSIVVHIDHRTGVKGADVVTKISQGDLINLTAILSIVDGQLQLRPFSLEQLDVVKK
                     VTSSNSDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDG
                     DLATSDGIRVFAKNAKVQVGDVLTISGEVEEFFGRGYEERKQTDLTITQIVAKAVTKT
                     GTAQVPSPLVLGKDRIAPANIIDNDGLRVFDPEEDAIDYWESMEGMLVAVDDAKILGP
                     MKNKEIYVLPGSSTRPLNNSGGVLLPANSYNTDVIPVLFKKGKQIIKAGDSYKGRLAG
                     PVSYSYGNYKVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFSANPSST
                     KDEKVKRIAESFIHDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGP
                     TYRYADIAPENNVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSV
                     GRIDPTNAAWKDVRKSLAAEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQR
                     RHVLANMLAQFAKEGAKHQANIVMLGDFNDFEFTKTIQLIEEGDMVNLVSRHDISDRY
                     SYFHQGNNQTLDNILVSRHLLDHYEFDMVHVNSPFMEAHGRASDHDPLLLQLSFSKEN
                     DKAESSKQSVKAKKTSKGKLLPKTGDSLVYVITLLGTASLLVPILLLTKGKKES"
     regulatory      11926..12041
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
     gene            12039..12539
                     /locus_tag="VHC05_000708"
     CDS             12039..12539
                     /locus_tag="VHC05_000708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QueT transporter family protein"
                     /protein_id="HEQ5402038.1"
                     /translation="MTKLTVHDYVHIGLVAALYVVLTITPPLNAISYGMYQFRISEMM
                     NFLAFYHRKYIIAVTLGCMIANFYSFGLIDVFVGGGSTLIFVTLGVILFSKYQKDYLF
                     NGIFNKAFVYFSFFFATSMFTVAIELYFFGAPFLLTWFTTALGELVSLLIGSLIIDKL
                     SQRISF"
     gene            12732..14690
                     /gene="ligA"
                     /locus_tag="VHC05_000709"
     CDS             12732..14690
                     /gene="ligA"
                     /locus_tag="VHC05_000709"
                     /EC_number="6.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="HEQ5402039.1"
                     /translation="MKKRIKELTDLLNRYRYDYYTKDAPSVSDSDYDKLYRELVTLEQ
                     SYPEYVLQDSPTQQVGGTILKGFEKYRHQYPLFSLQDAFSREELDAFDKRVKAEFPNA
                     TYLAELKIDGLSISLSYENGFLQVGATRGDGNIGENITENIKKIKDIPHQLSEPLTIT
                     VRGEAYMSRQSFKAINEARQENGETEFANPRNAAAGTLRQLDTAVVAKRQLATFLYQE
                     ASPTARNQQNEVLAELADLGFSVNPYYQLTSSMDEIWDFIKTIEAKRDQLAYDIDGVV
                     IKVNSLAMQEELGFTVKAPRWAIAYKFPAEEKEAEILSVDWTVGRTGVVTPTANLTPV
                     QLAGTTVSRATLHNVDYIAEKDIRIGDTVIVYKAGDIIPAVLNVVMSKRNQQEVMLIP
                     KLCPSCGSELVHFEDEVALRCINPLCPSLIQRSLEHFASRDAMNITGLGPAIVEKLFL
                     AGFVHDVADIYQLTKENFMQLDGIKEKSADKLLAAIEASKSNSAEKLLFGLGIRHIGS
                     KVSRLILEVYGDISALLTAKEEEIARIDGLGSTIAQSLTQYFEQKTAAILVDELKTAG
                     VNMHYSGQKVNSDAALFGLTVVLTGKLNQLNRNEAKDKLEALGAKVTGSVSKKTDLVI
                     AGSDAGSKLEKAKSLGIRIEDEDWLRQL"
     gene            14704..15726
                     /locus_tag="VHC05_000710"
     CDS             14704..15726
                     /locus_tag="VHC05_000710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
                     /protein_id="HEQ5402040.1"
                     /translation="MKKQLRARLIYNPTSGQELMRKSVPEVLDILEGFGYETSAFQTT
                     AQKNSALNEARRAAKAGFDLLIAAGGDGTINEVVNGIAPLKKRPKMAIIPTGTTNDFA
                     RALKVPRGNPSQAAKLIGKNQTIQMDIGRAKKDTYFINIAAAGSLTELTYSVPSQLKT
                     MFGYLAYLAKGVELLPRVSNVPVKITHDKGVFEGQVSMIFAAITNSVGGFEMIAPDAK
                     LDDGMFTLILIKTANLFEIVHLLRLILDGGKHITDRRVEYIKTSKIVIEPQCRKRMMI
                     NLDGEYGGDAPITLENLKNHITFFADTDLISDDALVLDQDELEIEEIVKKFAHEVEDL
                     EQELEE"
     gene            16134..16331
                     /locus_tag="VHC05_000711"
     CDS             16134..16331
                     /locus_tag="VHC05_000711"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit C"
                     /protein_id="HEQ5402041.1"
                     /translation="MNPIFALALACFGVSLAEGFLMANLFKAASRQPEIIGQLRSLMI
                     LGVAFIEGTFFVTLVMAFILK"
     gene            16366..17082
                     /gene="atpB"
                     /locus_tag="VHC05_000712"
     CDS             16366..17082
                     /gene="atpB"
                     /locus_tag="VHC05_000712"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="HEQ5402042.1"
                     /translation="MEEAKIPMLKLGPITFNLTLLAVCIVTIAVIFAFVFWASRQMKL
                     KPEGKQTALEYLISFVDGIGEEHLDHNLQKSYSLLLFTIFLFVAVANNLGLFTKLETV
                     NGYNLWTSPTANLAFDLALSLFITLMVHIEGVRRRGLVAHLKRLATPWPMTPMNLLEE
                     FTNFLSLAIRLFGNIFAGEVVTGLIVQLANYRVYWWPIAFLVNMAWTAFSVFISCIQA
                     FVFTKLTATYLGKKVNESEE"
     gene            17100..17594
                     /gene="atpF"
                     /locus_tag="VHC05_000713"
     CDS             17100..17594
                     /gene="atpF"
                     /locus_tag="VHC05_000713"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="HEQ5402043.1"
                     /translation="MSITFGELVGNFILVTGSVIVLLLLIKKFAWGAIESILQTRSQQ
                     ISRDIDQAEQSRLSAQQLEAKSQANLDASRSQASKIISDAKEIGQLQGDKLVAEATDE
                     AKRLKEKALTDIEQSKSDAISAVKTEMSDLTVLLAEKIMGANLDKTAQSQLIDSYLDD
                     LGEA"
     gene            17594..18130
                     /locus_tag="VHC05_000714"
     CDS             17594..18130
                     /locus_tag="VHC05_000714"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003057492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit delta"
                     /protein_id="HEQ5402044.1"
                     /translation="MTKKEQALIEQYAKSLVEVASEHHSLDTLQADVLAILETFETTN
                     LDQSLSSLAVPHAEKIKLLTLLERNNSVYMNNFLNLILQNEREAYLYQMLQAVLNEIA
                     IVSNQYNVTVTSSLPLTEEQKSRVRAVVAKKFAVTAGRLIEKVDPSLIGGFIISVNNK
                     VIDTSIRRQLQAFKMNLK"
     gene            18146..19654
                     /locus_tag="VHC05_000715"
     CDS             18146..19654
                     /locus_tag="VHC05_000715"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit alpha"
                     /protein_id="HEQ5402045.1"
                     /translation="MAINAQEISALIKKQIENFQPNFDVTETGIVTYIGDGIARARGL
                     DNAMSGELLEFENGAYGMAQNLESNDVGIIILGDFSAIREGDVVKRTGKIMEVPVGEA
                     LIGRVVNPLGQPVDGLGDIETTGFRPVETPAPGVMQRKSVSEPLQTGLKAIDALVPIG
                     RGQRELIIGDRQTGKTSVAIDAILNQKGQDMICIYVAIGQKESTVRTQVETLRRYGAL
                     DYTIVVTASASQPSPLLFIAPYAGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELSLL
                     LRRPPGREAYPGDVFYLHSRLLERSAKVSDDLGGGSITALPFIETQAGDISAYIATNV
                     ISITDGQIFLQENLFNSGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRLDLASYREL
                     EAFTQFGSDLDAATQAKLNRGRRTVEILKQPLHKPLPVEKQVVILYALTHGFLDDVPV
                     DDILAFEEALYDYFDVHYNDLFETIRTTKDLPEEAALDAAIKAFKEHSNFKS"
     gene            19670..20545
                     /locus_tag="VHC05_000716"
     CDS             19670..20545
                     /locus_tag="VHC05_000716"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000919083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit gamma"
                     /protein_id="HEQ5402046.1"
                     /translation="MAGSLSEIKAKIISTEKTSKITSAMRMVSSAKLVKSEQAARDFQ
                     IYASKIRQITTDLLKSELTIGSDNPMLVSRPVKKTGYIVITSDKGLVGGYNSKILKSV
                     MDMITEYHADGDYEIISIGSVGSDFFKARGMNVAFELRGLADQPSFEQVRQIISQSVD
                     MFVNEIFDELYVCYNHHVNSLTSQVRVQQMLPISDLVADEAAEEGVTGFELEPNRHDI
                     LDQLLPQFTESLIYGAIIDAKTAEHAAGMTAMQTATDNAKNVINDLTIQYNRARQAAI
                     TQEITEIVAGANALE"
     gene            20707..22113
                     /gene="atpD"
                     /locus_tag="VHC05_000717"
     CDS             20707..22113
                     /gene="atpD"
                     /locus_tag="VHC05_000717"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017643977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit beta"
                     /protein_id="HEQ5402047.1"
                     /translation="MSSGKIAQVVGPVVDVMFASGDKLPEINNALIVYKDSDKKQKIV
                     LEVALELGDGMVRTIAMESTDGLTRGLEVLDTGRAISVPVGKETLGRVFNVLGETIDL
                     EEPFAEDVDRQPIHKKAPSFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVG
                     KTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEP
                     PGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQP
                     TLATEMGQLQERITSTQKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLTQ
                     MGIYPAVDPLASSSRALSPEIVGEEHYAVATEVQRVLQRYRELQDIIAILGMDELSDE
                     EKTLVGRARRIQFFLSQNFNVAEQFTGLPGSYVPVAETVRGFKEILEGKYDHLPEDAF
                     RSVGPIEDVIKKAEKMGF"
     gene            22126..22542
                     /locus_tag="VHC05_000718"
     CDS             22126..22542
                     /locus_tag="VHC05_000718"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003088947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit epsilon"
                     /protein_id="HEQ5402048.1"
                     /translation="MTQMTVQVVTPDGIKYDHHAKCISVTTPDGEMGILPNHINLIAP
                     LQVHEMKIRRGGEDEKVDWIAINGGIIEIKDNVVTVVADSAERDRDIDVSRAERAKLR
                     AEREIAQAETTHNIDEVRRAKVALRRALNRINVSKK"
     gene            22808..23065
                     /locus_tag="VHC05_000719"
     CDS             22808..23065
                     /locus_tag="VHC05_000719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1146 domain-containing protein"
                     /protein_id="HEQ5402049.1"
                     /translation="MVCYNNPMELLMKIIAFSCHLFFIGLSYQLLISVIDWTKFSHYH
                     PENLGRLRLFVFLLATALGYLVSHCMLELLQISQTLFFEFR"
     gene            23130..24401
                     /gene="murA"
                     /locus_tag="VHC05_000720"
     CDS             23130..24401
                     /gene="murA"
                     /locus_tag="VHC05_000720"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HEQ5402050.1"
                     /translation="MDKIIIEGGQTRLEGEVVIEGAKNAVLPLLAASILPSKGKTILR
                     NVPILSDVFTMNNVVRGLDIRVDFNEAANEITVDASGHILDEAPYEYVSQMRASIVVL
                     GPILARNGHAKVSMPGGCTIGSRPINLHLKGLEAMGATITQKGGDITAQADRLQGAMI
                     YMDFPSVGATQNLMMAATLADGVTTIENAAREPEIVDLAQFLNKMGARIRGAGTETLT
                     ITGVTSLHGVEHDVVQDRIEAGTFMVAAAMTSGNVLIRDAVWEHNRPLISKLMEMGVS
                     VTEEEYGIRVQANTPKLKPVTVKTLPHPGFPTDMQAQFTALMAVVNGESTMVETVFEN
                     RFQHLEEMRRMGLQSEILRETAMIHGGRQLQGAPVMSTDLRASAALILTGIVAQGVTI
                     VNNLVHLDRGYYQFHEKLAKLGATISRSSEV"
     gene            24405..24593
                     /locus_tag="VHC05_000721"
     CDS             24405..24593
                     /locus_tag="VHC05_000721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HEQ5402051.1"
                     /translation="MTNGLKYVLEQMLLLLVIAALACLFLAIGLMIGYSFMGDGHSPW
                     HILSMDKWAELVNKFTGK"
     gene            24629..25493
                     /locus_tag="VHC05_000722"
                     /pseudo
     CDS             24629..25493
                     /locus_tag="VHC05_000722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184363.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA/RNA non-specific endonuclease"
     gene            25776..26819
                     /gene="pheS"
                     /locus_tag="VHC05_000723"
     CDS             25776..26819
                     /gene="pheS"
                     /locus_tag="VHC05_000723"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019314825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HEQ5402052.1"
                     /translation="MDLQAQLEELKTKTLETLQPLTGNHTKELQDLRVAVLGKKGSLT
                     ELLKGLKDLSNDLRPVVGKQVNEVRDLLTKAFEEQAKIVEAAKIQAQLDAESIDVTLP
                     GRQMTLGHRHVLTQTSEEIEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQ
                     DTFYITEEILLRTHTSPVQARTLDQHDFSKGPLKMVSPGRVFRRDTDDATHSHQFHQI
                     EGLVVGKNISMGDLKGTLEMIIKKMFGEERSIRLRPSYFPFTEPSVEVDVSCFKCGGK
                     GCNVCKKTGWIEILGAGMVHPSVLEMSGVDAKEYSGFAFGLGQERIAMLRYGINDIRG
                     FYQGDQRFSEQFN"
     gene            27029..29434
                     /locus_tag="VHC05_000724"
     CDS             27029..29434
                     /locus_tag="VHC05_000724"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002311998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="HEQ5402053.1"
                     /translation="MLVSYKWLKELVDIDVTPAALAEKMSTTGIEVEGIEVPAEGLSK
                     LVVGHVLSCEDVPETHLHLCQVDTGDETPRQIVCGAPNVKAGIKVIVAVPGARIADNY
                     KIKKGKIRGMESLGMICSLQELGLSDSIIPKEFSDGIQILPEEAVPGDAIFKYLDLDD
                     HIIGLSITPNRADALSMRGVAHEVAAIYGKSVSFPPKNLQESDKATSEAIEVAIASDN
                     VLTYASRVVENVKVKPSPQWLQNLLMNAGIRPINNVVDVTNYVLLYFGQPMHAFDYDK
                     FEDHKIVARAARQGESLVTLDGEKRDLTTEDLVITVADKPVALAGVMGGQATEIDANS
                     QTVVLEVAVFDGKSIRKTSGRLNLRSESSSRFEKGVNYATVLEALDFAAAMLQELAEG
                     QVLSGHVQAGQLPTEPVEVSTSLDYVNVRLGTELTFADIQRIFDQLGFGLTGDETSFT
                     VAVPRRRWDVSIPADLVEEIARIYGYDKLPTTLPEAGGTAAELTPTQALRRKVRGLAE
                     GLGLTEIISYALTTPEKAVEFAVAPSHLTELMWPMSVERSALRQNMISGMLDTVAYNV
                     ARKQSNLALYEIGKIFEQEANPKENLPNEVNHFAFAICGLVAQKDFQTQAQAVDFYHA
                     KGILDTLFANLNLKVQYVPTKDLANMHPGRTALILLDEQVIGFVGQVHPGTAKAYSIP
                     ETYVAELDMAALEAALSSDQTFVEITKFPAMTRDVALLLDREVSHQAIVTAIESAGVK
                     RLTKIKLFDVYEGVTIQAGKKSMAYSLNFQNPNDNLTDEEVAKYMEKITKALTEQVGA
                     EVR"
     gene            29544..29921
                     /locus_tag="VHC05_000725"
     CDS             29544..29921
                     /locus_tag="VHC05_000725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OsmC family protein"
                     /protein_id="HEQ5402054.1"
                     /translation="MYQTKITGNRLYHTVSKGYGDSVTLFGKTDQGETPMSLLVIALS
                     SCVTMCVQGFYHRQFQQDTLAVSVEASYEEEVFELLVRIDDVLDDKKKADLLAYIGTY
                     CRVKQLLKPEVTVTITLEGLSHV"
     gene            29914..30300
                     /locus_tag="VHC05_000726"
     CDS             29914..30300
                     /locus_tag="VHC05_000726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbgA family protein"
                     /protein_id="HEQ5402055.1"
                     /translation="MSDASLKTYQKQWAYQKYWVMAHSQQHYNALRELFKGNQWSEEK
                     VLTFHCLIEEAQAIPPTVKSLRTAYQHVWGYFKKVASQEEKKHFKDLDAQLETKSEEM
                     LCFLQEMTAHYQPSYLLSCRLITKGP"
     gene            30373..31449
                     /locus_tag="VHC05_000727"
     CDS             30373..31449
                     /locus_tag="VHC05_000727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402056.1"
                     /translation="MFLALNEMKQSKLRYGLIAGLLCLVAYLMFFLSGLAFGLMQENR
                     SAVDLWKADSVLLAKDADATLTLSQVSRAQENQITADKVAPLAQLNTVAWSVKNPKDA
                     DKVKVSLFGIDSNSFIRPNIVKGRLFKTNKEVVLDQSLAKEEAFAIGKDFYTSSSSQA
                     LTIVGYTQNARFSVAPVVYMNLEAFETLKYGGPLPKDKQVVNAFITKGSLTDYPKKDF
                     QKLDIKTFITKLPGYSAQLLTFGFMISFLVIISAIIIGIFMYILTIQKAPIFGIMKAQ
                     GISNKTITTAVLMQTFFLSFLGSGLGLLGTWLTSLLLPTVVPFQSNWFLYLAIFVSMI
                     CFALLGTLFSVFNIIRIDPLKAIG"
     gene            31459..32127
                     /locus_tag="VHC05_000728"
     CDS             31459..32127
                     /locus_tag="VHC05_000728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402057.1"
                     /translation="MSVLTFKQVTKTFQDGHHEINALKATDFSIEAGEFVAIIGPSGS
                     GKSTFLTIAGCLQTPSSGQLIIDGTDYTHLSEKERSRLRFKSVGFILQASNLIPFLTV
                     QQQLELVDHLTGSKEKAKANQLFDDLGITGLKHQLPQELSGGERQRAAIARALYHDPA
                     LILADEPTASLDTEKAYEVVKLLAKESKEKNKAIIMVTHDDRMLKYCDKVYRMQDGEL
                     CQER"
     gene            complement(32229..33146)
                     /locus_tag="VHC05_000729"
     CDS             complement(32229..33146)
                     /locus_tag="VHC05_000729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="neutral zinc metallopeptidase"
                     /protein_id="HEQ5402058.1"
                     /translation="MKTDDLRESQQVEDRRGQSSGSFGGGGLGGGLLLQLLFSRGGWK
                     TKLVILLLLLVMGGGGLSGVLGGKPSSTNNNAYQSSQVTRTNGDKASQEQVSFVSKVF
                     ASTEDYWTKTFREKGLTYHKPTLVLYTGATQTACGRGQASSGPFYCPGDQKVYLDISF
                     YNELSTKYGAKGDFAMAYVIAHEVGHHIQNELGIMDNYASARQGKSKAKANQLNVKLE
                     LQADYYAGAWANYVQGQGLLEKGDIEEAMAAAHAVGDDTLQEETYGRTVPDSFTHGTS
                     KQRQRWFDRGYQYGDFEHGDTFSIPYSKL"
     gene            33297..36512
                     /gene="rexB"
                     /locus_tag="VHC05_000730"
     CDS             33297..36512
                     /gene="rexB"
                     /locus_tag="VHC05_000730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent nuclease subunit B"
                     /protein_id="HEQ5402059.1"
                     /translation="MKLIYTEMSYSMTEILVNEARKAADQGYRVFYIAPNSLSFEKER
                     EVLTLLPERGTFSIIVTRFVQMSRYFTVESSPSKQHLDDTTLAMIFYRTLMQLKPEDL
                     PSYGRLQNNSVFIEQLVELYKELKNAQLSVHDLTGLDHPQKQEDLIKIIELAETIMIQ
                     QDYNQDSPLQSFARAIKLGLLNNQLSKTVVVIDGFSRFSAEEDYLLSLLNNNCQEVII
                     GSYVSQKAYQKSFIKGNIYEASLHFLQDLAQKYHIKPVFATSNQVFKPAFSRLTQLFE
                     ATHDFSQVDWQLQKNDLDHFSLWQCHHQKEEIEHVAKSIRQKLYEGYRYKDILVLLGD
                     MDAYQLQIGPIFDKFEIPYYLGKAEPMAAHPLVQFIESLERSQRYNWRREDILNMLKS
                     GLFGCFDDSDIDRFEEYTQFADIKGFTKFSKPFTINSSRQYPLDFLNEMRQDIVLPLQ
                     ELFKSQKQLGASLVDKLILFLKKIRLAENMQGLAQSQLEVEKNEEVWKRFTDILTSFH
                     HIFGQEKLRLSDCLALIKTGMKSAQYRVVPATLDVVTIKSYDLVQPHSKPFVYAIGLT
                     QSHFPKQIHHSGLLSDQERARINEIRNYRHFDIASAENSKKNHQTALSLFNAATKELV
                     LSVPTVINETFDDLSPYLKELINFGLPLLDKGKNYLSYDNSDIANYKALLSQIIAINR
                     QDLIEMSDQDKMFWTVVLRYLRKQLRKQQLELPTSDYRLSTKPLSKEVIEVCFPKGIP
                     LKLSATALTVFYNNQYNYFLKYVLNLNKTESIHPDSRIHGQYLHRVFERLMKDHTQEP
                     FDNKLKQAIYHTNQESFFQQVYQDNAEAEYSLAILEDIVRSTAPILQLNQNIQVIDQE
                     KNFQLDMGNEILVHGIIDRIDQLSDGSLGIVDYKSSANQFDIGTFYNGLSPQLVTYLA
                     ALKQIAPHDINQLFGAMYLHLQDPKLDLVTFKQIDNTLVESIYKALTYKGIFSEVEKE
                     HLSTGAYQTKNALYSNDELETLLNYNKYLYLKAAKHIKKGHFLINPYTSDGKTVQGDQ
                     LKAITRFEADLDMGQARRLVTLPAKEKKECFLTLMRKESHL"
     gene            36473..40141
                     /gene="addA"
                     /locus_tag="VHC05_000731"
     CDS             36473..40141
                     /gene="addA"
                     /locus_tag="VHC05_000731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020905049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddA"
                     /protein_id="HEQ5402060.1"
                     /translation="MLFNINEKGEPLVISFAPFLSPEAIKHLQENERCSDQSQKRTAQ
                     QIEAIYTSGQNILVSASAGSGKTFVMVERILDKILRGVSIDRLFISTFTVKAATELRE
                     RIENKLYSQIAQTTDFQMKVYLTEQLQSLCQADIGTMDAFAQKVVSRYGYSIGISSQF
                     RIMQDKAEQGVLKQEVFSKLFSEFMNQKEAPVFRALVKNFSGNCKDTSAFRELVYTCY
                     SFSQSTENPKIWLQENFLSAAKTYQRLEDIPDHDIELLLLAMQDTANQLRDVTDMEDY
                     GQLTKAGSRSAKYTKHLTIIEKLSDWVRDFKCLYGKAGLDRLIRDVTGLIPSGNYVTV
                     SKVKYPVFKTLHQKLKQFRHLETILMYQKDCFPLLEQLQDFVLAFSEAYLAVKIQESA
                     FEFSDIAHFAIKILEENTDIRQSYQQHYHEVMVDEYQDNNHMQERLLTLLSNGHNRFM
                     VGDIKQSIYRFRQADPQIFNQKFRDYQKKPEQGKVILLKENFRSQSEVLNVSNAVFSH
                     LMDESVGDVLYDEQHQLIAGSHAQTVPYLDRRAQLLLYNSDKDDGNAPSDSEGISFSE
                     VTIVAKEIIKLHNDKGVPFEDITLLVSSRTRNDIISHTFNQYGIPIVTDGGQQNYLKS
                     VEVMVMLDTLRTINNPRNDYALVALLRSPMFAFDEDDLARIALQKDNELDKDCLYDKI
                     QRAVIGRGAHPELIHDTLLGKLNVFLKTLKSWRRYAKLGSLYDLIWKIFNDRFYFDFV
                     ASQAKAEQAQANLYALALRANQFEKSGYKGLYRFIKMIDKVLETQNDLADVEVAAPKQ
                     AVNLMTIHKSKGLQFPYVFILNCDKRFSMTDIHKSFILNRQHGIGIKYLADIKGLLGE
                     TTLNSVKVSMETLPYQLNKQELRLATLSEQMRLLYVAMTRAEKKVYFIGKASKSKSQE
                     ITDPKKLDKLLPLALREQLLTFQDWLLAIADIFSTEDLYFDVRFIEDSDLTQESVGRL
                     QTPQLLNPDDLKDNRQSETIARALDMLEAVSQLNANYEAAIHLPTVRTPSQLKAAYEP
                     LLEPIGVDIIEKSSRSLSDFTLPHFSKKAKVEASHIGSALHQLMQVLPLSKPINQQTL
                     LDALRGIDSNEEVKTALDLKKIESFFCDTSLGQFFQTYQKHLYREAPFAILKVDPISQ
                     EEYVLRGIIDAYFLFDDHIVLVDYKTDKYKQPIELKKRYQQQLELYAEALTQTYKLPV
                     TKRYLVLMGGGKPEIVEV"
     gene            40281..41093
                     /locus_tag="VHC05_000732"
     CDS             40281..41093
                     /locus_tag="VHC05_000732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEQ5402061.1"
                     /translation="MNFKKIRFGFLLCLLLYPLAACNKSEQLNHYERIKKTRKLVVAV
                     SPDYAPFEFKALVNGKDTIVGADVQLAQAIADELDVDLELSPMSFDNVLSSLQTGKAD
                     LAISGISHTKERAKVYDFSIPYYQAENAIVMRASDAKVTKNISDLSGKKVAAQKGSIE
                     EGLVKIQLPKANLISLTAMGEAINELKAGQVYAVTLETPVAAGFLAQHKDLALAPFSL
                     KTSDGDAKAVALPKNSGDLTKAVNKVIAKLDEQERYKSFIAETIALTKNTMK"
     gene            41234..41410
                     /locus_tag="VHC05_000733"
     CDS             41234..41410
                     /locus_tag="VHC05_000733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000048061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /protein_id="HEQ5402062.1"
                     /translation="MSKTVVRKNESLDDALRRFKRSVTKAGTLQESRKREFYEKPSVK
                     RKRKSEAARKRKKF"
     gene            complement(41538..41900)
                     /gene="mscL"
                     /locus_tag="VHC05_000734"
     CDS             complement(41538..41900)
                     /gene="mscL"
                     /locus_tag="VHC05_000734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="large conductance mechanosensitive channel
                     protein MscL"
                     /protein_id="HEQ5402063.1"
                     /translation="MVKELKAFLFRGNIIELAVAVIIGGAFGAIVTSFVNDIITPLIL
                     NPALKAANVENITQLSWNGVKYGSFLGAVINFLIIGTSLFFVVKAAEKAMPKKEKEAA
                     APTQEELLTEIRDLLAQK"
     gene            42072..>42419
                     /locus_tag="VHC05_000735"
     CDS             42072..>42419
                     /locus_tag="VHC05_000735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000564846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISAs1 family transposase"
                     /protein_id="HEQ5402064.1"
                     /translation="MIDFIISIDDCAVELDSRQSWKIRSPLSTILFLVFVCQLASIET
                     WKEMEDFIEMNEPLFATYVDLSEGCPSHDTLERVISLVNSDRLKELKVQFEQSLTSLD
                     AVHQLISVDGKTIR"
BASE COUNT        13352 a         7209 c         8599 g        13259 t
ORIGIN      
        1 tcatttttta ctataataaa agtgataaga actagatagt tgttgtgtta caacagtaca
       61 attgagctag ccttgtcctt gttgtgttaa ctttattttt aaaataaggt taaaaataaa
      121 cgactcgtgt tcttatcagt tacttattag ataaggaggt aaaccttatg ttaaaattta
      181 cttcaaatat tttagctact agtgtagctg aaacaactca agttgctcct ggaggctgct
      241 gttgctgctg tactacttgt tgcttctcaa ttgctactgg aagtggtaat tctcaaggtg
      301 gtagcggaag ttatacgcca ggtaaataat ctatttagca tctctatgtg atagtgatat
      361 taaggtaatg agtttgctag caactaagtt atctttggta acttctgatt atagatgaat
      421 ggcatagagg tgttagaaaa catgagacaa aagtaatctt cttgatgcta acgtctcagg
      481 taattagcag gtactagaca gtacctgcta attactatat gtttagtaaa atgagatagg
      541 aaagatagtt atgtcatttt ttacaaagga acaacaacct aaagagaatt gtccgccaat
      601 aactgttgaa aaagcaaggc aattgtttga atttaataca aaccacttgt ccttatcgga
      661 ttaccatcat caaacggtgc taaaaacgtc aaagcagcta gttgctcaac atttaatgcc
      721 taatgcaacc gataatctta gtcaacattt tttgatgaac tataaagcta ataataatta
      781 tttaggcttc caagctagta ttgtcgactt ttttacagat tctgccgttg ctaatttttc
      841 aagtagttac gtttatgaaa gtcaggaaaa gataattcgt ttaccaaaac ctaccaagat
      901 atcaactgct ctgtcgacat gtattataaa acgaagaagt catcgtcaat tttcagatag
      961 acaaatgcct cttcaagatt tatcaaacat tctttattat gcatgtggtg ttagttcaca
     1021 agcatcaatt agagatggag catcagataa gattacactc agaaactgtg cttcaggtgg
     1081 aggtttatac cctattcatt tagtttttta tgctagaaac atcagtaaat taatagatgg
     1141 tttctatgaa tatctaccct atcagcatgc actaaggtgt tatcggcata gctctgagga
     1201 aaacgttaga gattttgcgg aatacggtgc tattaatgct gaaaattgta atattattat
     1261 tatttatgtc taccattaca tgaaaaatac acgtaaatat gggaatcagg cgactgccta
     1321 tgcttttatt gaatcaggag aaatagccca gaatattcaa ttgactgcaa ctgccttaac
     1381 ttatggaagt attgatattg gtggttataa taaggaatat ctccaagaat tattagattt
     1441 agatgggcta ggagagcatg tgattcacat gacactcgta ggaactaagg agtctcaatg
     1501 aaatatcaac ttaatagtaa tgttcgtgtc gtgacatttc aagatacatt ttgttttaga
     1561 aaaggaatct gggactttaa tgaagccatt ctagatttga cacaagaacc tcaaaattta
     1621 aagatagttt atcaagaaat agtttcacag ttggttaagg gagtagccat tgatactgaa
     1681 acttatgaaa atgctttaga acctgagacg ttcgctaatt taatggaagt catttcaggc
     1741 ttgtgttaca atgatatgct gatgcttgag gatgactaca atcttgaaga aaatgtcatg
     1801 aaaattttaa tgggtaattt ccgttttatg gcgcaagcag gtcatatggt aagcaatgat
     1861 cctgttttgt ttatcagtga ttcgacttat gttaatgaat ctgctgagtt gctagctgaa
     1921 caactgcatt tacaattgca agtggctagc gatgacttaa aaatgttaat tcagcagaca
     1981 gatgttagtt cgcgtttaga tgctttggag catcgccgta acatgaattg tttatcagaa
     2041 gccttgtgcg attaccaaag tattattatt tgtcaagaac gcttgaatat tatgatgttg
     2101 cgacacttga atgaagttag cgtagctatg aaaaaacaat tagtgattgg ttttgtagat
     2161 ggaccattct tgcacacttg tactttgaat cctcctcata gtgctgactt tgatagctta
     2221 gaaagaagag ttttggcacg tttacaagac tcaactctct atcaacattt tgctaatcag
     2281 attttaccag caacacaaga tgtgagccag gcctatttac cattgttaaa tgttttaatg
     2341 aatttagtcg ttagcgaagc tttcattatt gctcaaacag gtagttctaa atttgaggga
     2401 cgtttattaa gcatttactt accgacgctt gagattcagg tccaagatat tttgaaaatg
     2461 tctaattcac agacacaagg agctttggca aaattaaaat atgaggatca gcagatatca
     2521 acacgtgaga ttgttaaaaa actccttgac gagtaaccta taaggagaat ctattatgtt
     2581 atactattat ccttctttta atcatatttt tgatgaatta aaaagtttaa gtggcaatcg
     2641 aacaggtatc ttaaatcaat ctcaagttcc agtttgcaac catcctcacg atgtttactt
     2701 aaaaagtatt actggccaaa tgccagatta tcataaacaa tttataggtg agttgagtca
     2761 agttagttat cacattattg gttacggcag ttactatgaa gaagcactta tcaagtattt
     2821 aggagaaagt attgaacgct atgctactgt aattgccgga gacttactat cagatcggat
     2881 tgtctatgct tcttataatg agttaaaact gttacataaa gtgatgcctt tagaatactt
     2941 gcaagtgttt actcaagaac agatcgcatt atcttgtgac ttgcaaatga tgatgtgcga
     3001 taaaatggta actgagaacg atgtattggg ctgggttaaa tgtcccatgt tctttgagga
     3061 cgcagagatg tatgttccag ctcaaatgct ttgtgttggg tataaaacaa atgagactgt
     3121 aggagaaaga cggataatac caggattttc tacgggaaca gcttctcaca aaacgttaga
     3181 agcggctatg tgcaacagtt tgattgaata catccagatc gattcaatga tgcttagctg
     3241 gtatactaag aagccttgcc ccaagattat tgttgatgat cctgatattg aagtgatttt
     3301 agaagaagct agactgggaa aagacagtct atacgacatt attcctatcg atatgactgt
     3361 aggagaagat aatcctcttt atacgtttgg aatcattctc aaaaataaat atgatgaagg
     3421 gccttacctc ttgtttggag tgcaggctgg gttagatcct aaacatgctt tgctaagagg
     3481 gatcatggaa gcttcagcta tcagctatag ttactactat aatcttttat atcaaaaagc
     3541 ttcccttgca aatattgaat gcgaagaacc tttgttttta gatttagata gtaatgtttt
     3601 ctattatgca catcccaagg accaagacca taaatggaag gcctttgaac ctttgatttc
     3661 aggagaagtt ctgttaagtg atttggaaga tcattctggt aaagataaaa aagaagattt
     3721 gaagacttta ttagcttatg ctaagaaagt cagtcctaat gctgtctttt tagatattac
     3781 acctcctgaa gctctagaaa aaggctggta cgtcacgcga gttctgatgc cagaacttct
     3841 tgaaatgtgt ataccagcat ttccttttgc taatcaccca cgaatgagac agtttggagg
     3901 tgtaacaaat gcctttgtcc atccaatgcc ttaatctttg ttttttgttg gtaacttttt
     3961 gtccttcaat tcctatgcaa gctatttttg gaaaagaaga tagtggttat gcatttaatt
     4021 taattggttt tctaagagca actctgattt atgacatttt ggctttggta agtatttatg
     4081 ttttgtcacc tcaaataacc ttgtcttttg aaagtattga tagtaagacg ttctttatgg
     4141 gacttgtatt ttgcgtcttg atagtactga ttgaactcgt tttcttacat ggtttacgtt
     4201 gttggcaaaa aaagcaatgg cttcctgcaa ctttctcgtt tgtaggaacg acaaatgatt
     4261 ggtctaagat tggctatcct ttattactag ctttatttga agagacgatt tatcgttttt
     4321 tgtggtttaa tatattagct tttcaatggc atttaccaac aattattgtt ttaattgtaa
     4381 ctagtttttg ctatgcttta aatcacttat tgatggggaa atccattttt tatgctaagt
     4441 tggtaacagg catcatttat agtagtattt acatgctgac tagtcaattg tggttggttg
     4501 tgataatgca tgtaggaggg aacttgctag ttgagtgtct tagccatctt caaacaaaaa
     4561 agaagaagga ggtgacatga tgctattggt tttgctgtcg tttttaggtc taactactct
     4621 ttggttgacc agttatcgaa gacgttgttt ggctagatgg catcttcaat ggttagtggc
     4681 cttatcctat caagattttt tagatgtctt actgagtctg tttcaatttg tcattattat
     4741 acttgtttta ttcttttact cagctactat taatctagga gaggttctga cctttttgac
     4801 acaaactagc tggcattggc agattctttg ttatttagtg ttgtatctta tggccatcat
     4861 agagatgacg cttttagttt taattcttat ctttgatgtt ttgctccaga aagatagtcg
     4921 attgctcttt aaaaaaataa cttggctgcc ttttagacaa gataaaccag tcttaagtat
     4981 acttttgcta ggcatagcta ttctagtaga cagtctcttt tatttgggct tgcttatatt
     5041 attaggggaa cagtcgctaa caagtttagc aacgcttatt ttaggttatg ggatagtcaa
     5101 ggcttgtcgc tattcaggct ggttaaatgt actattagct ttttgtcttt tcactatagt
     5161 tggactatgg gcagttacgg caactttatt atatggttgg ctagtaggtg cgatgatatt
     5221 aatggtgact tatttgatga ttagttgcaa agagtattag caatattaaa aaggagtgat
     5281 atatgagttt tgtacaatta acaaatgttg tcaagtccta caaaaacggc aagaaagctg
     5341 tcaatgatgt ttccttgtct attgaagcag gtaatattta tggtttgtta ggaccaaatg
     5401 gtgctggtaa gtctaccttg attaatctta tcttaggctt gatccctttg agttccggta
     5461 aaattactgt tttagggcaa tcccaaaaga ctattcgaaa aataagttcg cagataggtt
     5521 atgttcctca agacattgct gtttatccag acctaactgc ttatgaaaat gtagaactat
     5581 ttgggtcact ttatggctta aagggagctc agcttaaaaa acaagttcta aaaagtttag
     5641 aatttgtggg actacactcc caagctaagc agtttccaag tcaattctca ggaggaatga
     5701 agagacggtt aaatatcgct tgtgcgctag ttcattcacc taaattaatc atttttgacg
     5761 aaccgactgt agggattgat cctcaatcac gtaatcatat tttagagtcg attcgtttgc
     5821 taaacaaaga aggtgccaca gttatttata cgacccatta tatggaagaa gtagaggctc
     5881 tttgtgatta tatttttatt atggatcatg gtcaagttat tgaagaagga cctaaatttg
     5941 aactggaaaa acgttacgtt gcaaatctag caaaccagat tattgtaact ctaacagatt
     6001 cacgtcattt ggaactggca gataagcctg attggtcttt gatagaagat ggagaaaaac
     6061 tcatgttgaa gattgataat agtgatatga catcagttgt tcatcagctc acacaggcca
     6121 atattacttt tagcgagatt agacataacc atttgaattt agaagaaatt ttcttacact
     6181 taacaggtaa gaagttacga gattagaggt tactatggtt ttatttcatt taatcaaaaa
     6241 agaaagttta cagattttta gaaaccgaac agccttattg atgatggtga tttttccaat
     6301 tttgatgatc gttattttaa gttttgcctt taaatcaagt tttaatactg cgacaacagt
     6361 ccctaaattg accattcgtt accaattaga gggtgaaaaa acggattacc agaaaaattt
     6421 tcttgctttt ttaaaagttt taaaccaaaa acttcattta gaggctaaac ctagtaattc
     6481 tcttgaaaaa gatcgacaaa gggtcagtga aggagcctta acggctgttt tagaagtgaa
     6541 gaagaatcag accattaagg ttattactaa taatattaat cagcaaaatg cagatttaat
     6601 caatatgcta gtaaaaaatt atgtagataa tgctaaaact tatgactcga tagcagctct
     6661 ttatcctcaa caattaaatc atatcagaaa gcgaagtgtg gactatgtta aggtcagttc
     6721 aatacagaca agtaaaggaa tgacatcagc tgattattat gctatttcca tgtttaccat
     6781 gattactttt tatagtatga tgtctgcgat gaaccttgtt ttgtcagatc gtcaacaacg
     6841 gattacaaat cgtattcgct taacaggagt ttctccaagt cttttagtct ttgggaaatt
     6901 aataggtgct atgttagcaa caactgttca attgagtctt ttatacattt ttacaaggtt
     6961 tgttttacga gttaattggg gcactaatga gtggatgctt attggtataa cagcctcctt
     7021 agtctatctc tctgtagcta taggtatcgg gctaggcata agcattaaaa atgaggcttt
     7081 tttaacggtt gcatccaata ctattattcc tatattcgcc tttttaggag gcagttacgt
     7141 tccattgaca acattacaca gctctattat taatcaattg tcgaatatat ctcctattaa
     7201 atgggttaat gatagtttgt tctatcttat ttttggtggt caatataatc cgattcctgt
     7261 aactttgatc gttaatatta gtatcggaac aatttttata atattggcat taataggtat
     7321 gagaaagcag gtgacgacat gatttgtttt ataaaaactc tatttgttaa gataaagcgc
     7381 aaaaaaacaa gttatgtgac attcttttta atgcctattt taacgacact tttggcttta
     7441 tctttgagtt tttcaaataa taatcaggct aaaattggga tattagataa agataatagt
     7501 cagatatcta aacaatttat tgctcaacta aagcaaaaca aaaagtacga catttttacc
     7561 aaaatcaaaa aagagcatat tgatcactac cttcaagata aatctctaga agcggtattg
     7621 actattgata aagggttctc agataaagtg ttgcaaggaa aatctcaaaa actcaatata
     7681 cgttcgattg ctaatagcga aattacagag tgggtaaagg cacagaccaa ttatctattg
     7741 gaaaactata atattatagg ggatgtggct ctaggtaacg aagatacttt taatagaatt
     7801 ctccaaaaaa accaacagtt aaactatgat gttaagcaag taactttgac agaccgatca
     7861 cgtagcaaag cagtatcttc cacaacgaca ggatttttgc ttattctaat gttaggtagt
     7921 acgagcgtga tttacagtgg tattttggca gataaatcta gtcagttata ccatcgatta
     7981 atgttatcga acttatctcg ttttcgctat atgttgagtt acgtctgtgt aggatttgtt
     8041 gcttttacga ttcaaattgt cattatgctg agtttgttaa aagtatttaa tattagtttt
     8101 tttgttccga catcacttct tttgattatt tttttccttt ttagtttatt agcgataggc
     8161 tttggcctgc tgattggagc tatcacacaa aattcccaac aaagtagcca gttagctaat
     8221 cttattgtaa tgccgacttc aatgttggct ggctgtttat ggccattgtc tattacgcct
     8281 tcttatatgc aagcaattgg taagttatta ccacaaaatt gggttttatc agccatagct
     8341 atttttcaaa gtggagggac cttatctcag gcttggccac acttgttagc tctaatggga
     8401 acagcactag ctttgattat tttttcaagt ttattattaa aacctaccag actataatta
     8461 gtcttttgtt aaaaaatact ttcctaatta gctaactacc aggtagccct tttattggct
     8521 tatatgcaat aaaagggttg ctttttgctt atattttctc tagtgtactt atcttttgtt
     8581 aaaagtgatt gcgatgttac tgttgttact gtgtttttta gagagcatat tatcaaaagc
     8641 gacctctcta gaaagttcgt ttttgttgat aaatgagttg tcaaagtatt ttaaaaaaac
     8701 gttttcaata aacataaaaa ctaatgttat taaaaaaaag tgtaaaaacg tatttatttt
     8761 atgaaatgtt tttgttacaa taagcatgta tcgaatgcta taaagctgtc ttgttcgcta
     8821 tcaggggtgc ttgtgatgct atgtcagatc aaacaagtct ttaattgggt gacttaacag
     8881 attaaaagaa aagatctaat cgtgttactt gatagtataa ttaatgcaaa cagaaagtgt
     8941 atcccaattc atagtctcag gtggaggtta atattcaaaa ataaaatctt gttgttgtct
     9001 taaactaatc acattaaaag gagatatcat gattaacaag aaatatataa tacctgtttc
     9061 attgttgaca ctagctatta cgcttactag tgttgaagaa gttacttcac gtcaaaattt
     9121 gacttatgcc aatgaaatcg taacacaaag gccaaagaga gaatctgtta ttagtgataa
     9181 atcgaatttt cccgtcatat caccttacct agcaagtgtg gattttggtg agagaaaaac
     9241 acctttgcca acacctgata aaggagtaaa agtaactact gaacagtcta ttgctcaagt
     9301 aagaaagggg cctgaagaaa gaacctatac tgttactggc aagattacga gtgtgatcaa
     9361 tggctgggga ggctatggct tttatattca agatagtgaa ggtattggac tttatgttta
     9421 tcctcaaaaa gatttaggat acagtaaggg agatattgtt caattaacag gtacacttac
     9481 tcgctttaaa ggtgatttac aactccaaca ggtgactgca cacaaaaagt tagagttatc
     9541 ttttccgact tctgttaaag aagcagtaat atcagaatta gaaacaacaa caccctcaac
     9601 attagttaag ttatctcacg tgacagttgg agaattatca actgatcaat ataacaacac
     9661 atctttcctt gtaagggatg atagtggtaa aagtatagtt gttcatatag atcatcgtac
     9721 aggggttaaa ggggctgatg ttgttactaa aataagtcag ggtgatttga ttaacctcac
     9781 agccatattg tctattgttg atggtcagtt acaattaaga ccgttttctc ttgaacaatt
     9841 ggatgtggtt aaaaaggtta caagctcaaa tagtgatgct tcatctcgta atattgtgaa
     9901 aataggcgag attcaaggag ctagtcatac gtcgccactt ctcaaaaaag cggtcaccgt
     9961 agaacaggtt gttgtcactt atttagacga ttccactcat ttttatgttc aagatcttaa
    10021 tggtgatggt gatttagcga cttcagatgg tattcgtgtt tttgctaaaa acgctaaggt
    10081 tcaagtcggc gatgttttga ccatttcagg tgaagtggaa gaattctttg gtcgtggtta
    10141 tgaggaacgt aagcagactg accttaccat cacccaaatt gtggctaaag cagtgaccaa
    10201 aacagggaca gctcaagttc catcaccgct tgttttaggg aaagatcgta tcgcgccagc
    10261 caatattatt gataatgatg gcttgcgtgt gtttgatcca gaagaagacg ctattgatta
    10321 ttgggaatca atggaaggca tgttagtggc ggttgatgat gctaaaatcc ttggtccaat
    10381 gaaaaataaa gaaatttatg tcttacctgg ctctagtaca agaccgttaa ataattcagg
    10441 tggagtatta cttccagcta attcttataa cacagatgtg attcctgttc ttttcaaaaa
    10501 aggcaaacaa attattaaag caggagactc ttacaaagga agattagctg ggccagtatc
    10561 ttatagctat ggtaattaca aggtctttgt tgatgacagc aaaaacatgc caagtttaat
    10621 ggatggtcat ctaaaacctg aaaaaacaaa cttgcaaaaa gaccttagca agttaagcat
    10681 tgcttcttac aatattgaaa acttctcagc caatccttct tcaactaaag atgagaaggt
    10741 caaacggatt gccgaatcct ttattcatga tctgaatgct ccagacatta ttggattaat
    10801 tgaagtccaa gataataatg ggccgactga tgatgggaca acggatgcga cacaaagcgc
    10861 acaacgcctc attgatgcta ttaaaaaact aggtggccca acttatcgtt atgctgatat
    10921 tgctccagaa aataatgttg acggaggtca accaggtggt aatattcgaa caggattcct
    10981 ttatcaacca gagcgcgtca gcctttctga taagccaaaa ggcggtgctc gtgatgctct
    11041 aacttgggtt aatggagaat taaaccttag tgttggtcga attgatccaa ctaacgccgc
    11101 ttggaaagat gttcgtaaat cactagcagc agaatttatc ttccaaggtc gtaaagtcgt
    11161 tgttgttgca aatcatttga actctaagcg tggggataat gctctttatg gtcgtgtgca
    11221 accagtcact tttaaatctg agcaaagacg tcacgtcttg gctaatatgc tagcacaatt
    11281 tgcgaaagaa ggggcaaaac accaagctaa tattgtgatg ctaggtgact ttaatgattt
    11341 tgaattcaca aagacgattc aattaatcga agaaggtgat atggttaact tggtgagccg
    11401 acatgatatt tcagatcggt attcttattt tcaccaaggc aataatcaga cccttgataa
    11461 tatattagtt tcacgccatt tacttgatca ctacgaattt gacatggttc atgtgaattc
    11521 cccatttatg gaagcgcacg gacgcgcatc agatcatgat ccattgttac ttcaattatc
    11581 attttctaaa gaaaatgata aggcagagtc ttctaaacaa agtgtaaaag ctaaaaaaac
    11641 ttcaaaagga aaactgttgc caaaaacagg agatagtctt gtttatgtga taacgctact
    11701 aggaacggct agtttattag tgcctatttt attattgact aaaggcaaaa aggaatcata
    11761 gcgatttgaa gaattggagt tcataaagag tcgttaaagg cttgatatac ttacgttaga
    11821 ccttaagcta aaatggatga ctatataaaa actaagattg ataacaaaag aagataacaa
    11881 taagatagct ttacttgcta aagacttttg tcaagctaat tgttttatgg tacaatgtaa
    11941 ccgttgcttt gcaacccttg gtgcttagtt ccctttcacc aagcatatta gaaacgtaga
    12001 tagcttttga gagttatcca gacgttaaag gagaaaaaat gacaaaattg actgtacacg
    12061 actatgttca cattgggcta gtagctgcct tgtatgttgt cttaactatt accccacctt
    12121 taaatgcgat ttcttatggg atgtatcaat ttagaatatc tgaaatgatg aatttcttag
    12181 ctttttatca tcgcaagtat attattgcgg tgactcttgg atgtatgatt gctaactttt
    12241 atagtttcgg actgattgat gtctttgtag gcggcggttc aactcttatt tttgtgacct
    12301 taggtgtgat tttgtttagt aagtatcaaa aagattatct ttttaatggt atttttaata
    12361 aagcttttgt ttacttttct ttcttttttg caacttccat gtttactgta gcaatcgaac
    12421 tttacttctt tggagctcca tttttattaa catggtttac aactgcgtta ggagaattag
    12481 tatctctgct cataggatca cttattattg ataagttgtc tcaaagaatt tccttttagt
    12541 aatgcatcat actcaaaaga gttgggtcaa tacccttctc ttttttatgt tgtttgtaat
    12601 gttaaaatcg ttctaataga aatatttaac actttagcta atagtaccat atggagtggc
    12661 caacgattac ttttgatgtt gttatgatat agaaatagct catttgttat cttttatgat
    12721 aaaataaaag tatgaaaaaa cgcataaaag aattaacaga tcttcttaac cgttaccgtt
    12781 atgactatta tactaaagat gccccatcag tttctgacag tgactatgat aagctttatc
    12841 gtgaactggt gactttagag cagtcatatc ccgagtatgt cttgcaagat agcccaacgc
    12901 agcaggttgg agggactatt ttaaaggggt ttgaaaaata tcgacatcag tatccgcttt
    12961 ttagtttgca ggatgctttt tcacgtgagg agctggatgc ttttgataag cgcgtcaagg
    13021 ccgaatttcc gaatgccacc tatctagcag agttaaaaat tgatggttta tctatttcct
    13081 tgagttatga gaatggcttc ttacaggttg gagcaacacg gggtgatggc aatatcggtg
    13141 aaaatatcac agaaaatatc aaaaaaataa aggatattcc tcaccaattg agtgagcctt
    13201 taaccatcac cgttcgagga gaggcttaca tgtctcgtca gtcctttaaa gcgatcaatg
    13261 aagcacgcca agaaaatggg gagactgaat ttgctaatcc tagaaatgct gccgctggga
    13321 cactaaggca gctagatacg gcagtggttg ctaagcgtca actagccact tttttgtatc
    13381 aagaagctag tccgacagct agaaatcaac aaaatgaggt cttagcagaa ttagcagatc
    13441 taggtttttc agtaaatccg tattatcaac tcacatcgtc tatggatgag atttgggatt
    13501 ttatcaaaac tattgaggca aaaagagatc aattagctta tgacatagat ggcgttgtta
    13561 ttaaagttaa tagcctagcc atgcaagaag agctagggtt tacggttaaa gctccacgct
    13621 gggccattgc ttacaaattt ccagcagaag aaaaagaggc agaaatcctt tcggttgact
    13681 ggacagtggg acgaacaggc gtggtcacac ctacagcgaa tctaactcct gtgcaactag
    13741 cggggacaac cgtgagtcgt gcaaccctac ataatgtgga ttatattgcc gaaaaagata
    13801 tccgtattgg cgatacagtg attgtatata aggcagggga cattattcct gctgtcttaa
    13861 atgtcgttat gagtaagcgg aaccagcaag aagtcatgct tattcctaaa ctatgcccat
    13921 cttgtggtag tgaattagtt cattttgagg atgaggttgc tttgcgttgt attaatccgt
    13981 tgtgtcctag tttgattcag cgaagtttgg agcattttgc aagtcgtgat gccatgaaca
    14041 ttactgggct gggaccagct attgtggaaa aactattttt agcggggttt gttcatgatg
    14101 ttgctgatat ttaccagttg accaaagaaa atttcatgca attagatggc atcaaagaaa
    14161 agtcagctga taaattgctc gctgcgattg aggcttctaa atcaaattca gctgaaaaac
    14221 tgttatttgg tctaggaatt cgtcatattg gctctaaagt tagtcgctta attttagagg
    14281 tatacggaga tatttctgct cttttaaccg ctaaagaaga ggaaatcgca aggatagacg
    14341 gccttggctc aacgattgct caatcactta ctcaatactt tgaacaaaaa acggctgcga
    14401 ttttagtaga cgagttaaag acagcaggtg tcaacatgca ttactcaggt caaaaagtta
    14461 atagtgacgc agcgcttttt ggtctaactg ttgttttaac tggcaaatta aatcagctga
    14521 accgaaatga ggccaaagat aaattagagg cattaggtgc caaagttact ggaagtgtat
    14581 ctaagaaaac agatttagtt attgcaggta gtgacgctgg ttctaagcta gaaaaagcaa
    14641 agagtttagg aattcggatt gaagatgaag attggctacg ccagctttaa gtgaggtaat
    14701 gttatgaaaa aacaattgag agcacgtctc atttataatc caacgtcagg acaagaactt
    14761 atgagaaaaa gtgttcctga agttttagac atattagaag ggttcgggta tgaaacatct
    14821 gcctttcaaa caacagccca aaagaactct gctctaaatg aagcaagaag agcggcaaag
    14881 gcaggttttg acttattgat tgctgctgga ggtgatggca ctattaacga agtggtcaat
    14941 ggaattgctc ccttgaaaaa gcgccctaaa atggccatta ttccaacagg taccactaat
    15001 gattttgcta gagcgttaaa agtaccaaga ggaaatccga gccaagcagc aaaacttatc
    15061 ggaaaaaatc agactatcca gatggatatt ggtagagcta agaaagatac ttatttcatc
    15121 aatattgctg cagcaggaag tttgacggaa ttaacttaca gtgtaccaag tcagttaaaa
    15181 acgatgtttg gatacttggc ttatcttgct aaaggagtag aactgctccc aagagttagc
    15241 aatgtgcctg ttaaaattac gcatgacaaa ggcgtctttg aaggtcaagt ttctatgatt
    15301 tttgcagcta ttaccaattc tgttggggga tttgaaatga ttgctcctga tgcaaaacta
    15361 gatgacggta tgtttacgct cattttaata aagacagcaa atctttttga aattgtacat
    15421 cttttgcgtt tgattttgga tggtggtaag catattacag atcgccgtgt cgaatacatt
    15481 aagaccagta aaatagtcat tgaaccccaa tgtcgtaagc gaatgatgat taatttagat
    15541 ggcgagtacg gaggagatgc tccaattaca ttagagaacc taaaaaatca tatcactttt
    15601 tttgcagata ctgatttgat ttctgatgac gctttagtct tagatcagga cgaattggaa
    15661 attgaggaaa tcgtaaagaa atttgctcat gaagtagaag acttagaaca agaattagaa
    15721 gaataataca atagttatta gctactgaca gtttagtcaa atgcactact attagaatct
    15781 attattttta taatctaaga tttttaaatc aattgaggta gtgttttttg atgcactcaa
    15841 agagtcaatt tattcatatg aggagtccat ttgaggtctc tcttttttga tcatatgcaa
    15901 gaaaatgcca tgttttaggg gtgttattat accctttttg gaatcttgtt gcctttttgt
    15961 tataataaga gtgtaattct atttttaaaa agatcttaac aaagacagac tcgtttatca
    16021 aaaaggttag tattagtcta agaaagcgta ctcagtctaa agaaatctgt tgacattctt
    16081 aattttaagg aatagaatag caaagtaaaa aaaatttaaa ggagtattct actatgaatc
    16141 ctattttcgc attggctttg gcctgttttg gtgtttctct tgccgaaggt ttcttgatgg
    16201 caaatctttt taaagcagca tctcgccaac cagaaatcat tggtcaatta cgttcattaa
    16261 tgatcttggg tgttgccttt atcgaaggta ctttctttgt tacccttgtt atggccttca
    16321 ttcttaaata acagcctatt tgataataga aaaggagggt gttagatgga agaagctaaa
    16381 atacccatgc taaagcttgg tccaataacc tttaatttga ccctacttgc tgtttgtatt
    16441 gtcacaattg ctgttatctt tgcctttgtt ttttgggcaa gtcgccaaat gaaattgaaa
    16501 ccagaaggga agcaaactgc tttagaatat ttaatcagtt ttgtggatgg tattggagaa
    16561 gagcacttag atcataatct acaaaaatct tattcgctgt tactctttac catttttctc
    16621 tttgtggctg tcgctaataa tttagggtta tttactaagt tagagacagt taatggctat
    16681 aacctatgga cctcgccaac agccaatctg gcttttgacc ttgctctatc tctttttatt
    16741 accttaatgg tacacattga aggggttaga cgtcgtggct tggttgccca tttgaaacgt
    16801 ttggctacac cgtggccaat gactccgatg aatttattag aagagttcac aaatttctta
    16861 tcacttgcca ttaggttatt cggtaatatc tttgccgggg aagttgttac aggtttgatt
    16921 gttcaactgg ccaattatcg agtttattgg tggccgatcg ctttcctagt caatatggcg
    16981 tggacagcct tttcagtctt tatttcctgc atacaggctt ttgttttcac aaaactaaca
    17041 gcgacctatc taggaaagaa agttaatgaa tcagaagaat aaggaaggag aacaaacgaa
    17101 tgtcaatcac atttggtgaa ctcgttggga attttattct agtaacaggt tctgtaatcg
    17161 tcttgttact cttgatcaaa aaattcgctt ggggtgcaat tgaatcgatt ttacagacac
    17221 gctcacaaca aatctctcga gatattgatc aggctgagca atcacgtcta agtgctcaac
    17281 agttagaggc aaaaagtcaa gctaacctag atgctagtcg ttcacaagca agtaaaatca
    17341 ttagtgatgc caaagaaatt ggtcaattac aaggtgataa attggtggca gaagctactg
    17401 atgaagcaaa acgcttgaaa gaaaaagcgt tgacagatat tgaacaaagc aaatcagacg
    17461 ctatttcagc agtcaaaaca gaaatgtctg atttaacggt tcttttagcg gaaaaaatta
    17521 tgggagccaa tcttgataag acggcgcaaa gccagcttat tgacagttat cttgatgact
    17581 taggagaagc ttaatgacca aaaaagaaca ggctcttatc gagcaatatg caaaaagcct
    17641 tgttgaggta gcaagtgaac atcattctct tgatacctta caagctgatg tgcttgcgat
    17701 tttagagacg tttgaaacaa ctaatcttga tcaaagtcta tcaagtctag ctgttccgca
    17761 tgctgaaaaa ataaaattgc taaccttatt agagagaaat aattctgttt atatgaataa
    17821 tttcttgaat ctcattttac aaaacgaacg tgaagcttat ttgtatcaaa tgcttcaggc
    17881 tgttttaaat gaaattgcaa tagtttcaaa tcagtataat gtgactgtta cctcatcact
    17941 acctttgact gaggagcaaa aaagccgtgt tcgagcagtt gttgcaaaga aatttgctgt
    18001 aacagcgggt cgtttaattg aaaaagtaga tccttcgctt attggaggat ttattatcag
    18061 cgtcaataat aaagtaattg ataccagtat tcgtcgtcaa ttgcaagcat ttaaaatgaa
    18121 tttaaaatag aaagtggtgt gacttttggc aattaatgca caagaaatta gcgctttaat
    18181 taaaaagcaa attgagaact tccagccaaa tttcgatgtc acagaaactg ggatcgttac
    18241 ctatattggt gacggtattg cacgtgcccg tggattagat aatgccatga gtggtgaact
    18301 tcttgaattt gaaaatggtg cctatgggat ggctcaaaac cttgagtcaa atgatgtagg
    18361 tattattatt cttggtgatt tttcagcaat ccgtgaagga gatgtggtta agcgcaccgg
    18421 taaaatcatg gaagtaccag ttggtgaagc tctcattgga cgtgtggtaa acccacttgg
    18481 acaaccagtt gatggcttgg gagatattga aacaactggc tttagaccag tcgaaacgcc
    18541 agctcctggt gttatgcagc gtaaatccgt ttctgaaccc ttacaaactg gattaaaagc
    18601 aattgatgct ttggttccaa ttggtcgtgg gcaacgtgag ttgattatcg gagaccgtca
    18661 aacaggaaaa acatccgtag ctattgatgc gattttgaac caaaaaggtc aagacatgat
    18721 ttgtatctat gtggctattg gtcaaaaaga atcaaccgtt cgtacacaag ttgaaaccct
    18781 tcgccgttac ggtgccttgg attatactat tgttgtgaca gcgtcagcct cacaaccatc
    18841 accattgctc ttcatcgctc cttatgcggg tgttgccatg gctgaagaat ttatgtacca
    18901 aggcaagcat gtcttgattg tctatgatga tttatcaaaa caagcggtgg cttatcgtga
    18961 attgtctctc ttgcttcgtc gtccaccagg tcgtgaagct tacccagggg atgttttcta
    19021 cttgcatagc cgtcttttgg aacgctctgc aaaagtttct gatgacttag gtggaggttc
    19081 tatcacagct ctaccattta tcgaaacaca ggccggagat atctctgcat atattgcgac
    19141 taacgttatt tcgattacag acggacaaat cttcttgcaa gagaacctct ttaattcagg
    19201 aattcgtcca gcgattgatg caggatcatc tgtctcacgt gtaggtggtt cagctcaaat
    19261 taaagcgatg aaaaaggttg ctggtactct tcgtttggat ttggcttcct atcgtgaatt
    19321 agaagccttt acccaatttg gttcggacct tgatgctgca acacaagcaa aacttaatcg
    19381 tggtcgccgt acggttgaaa tcttgaagca accattgcat aaaccgttac ctgttgaaaa
    19441 gcaagtcgtt attctttatg cccttactca tggtttctta gatgatgttc ctgtagatga
    19501 tattttggct tttgaagaag ctctttacga ctactttgac gttcattaca atgatttatt
    19561 tgaaactatc cgtaccacaa aagaccttcc tgaagaagct gcccttgatg ccgctattaa
    19621 agcgtttaaa gaacactcaa actttaagtc atagagggag gatactagta tggcaggctc
    19681 tctaagtgaa attaaagcta aaattatttc aactgagaaa acaagtaaaa tcactagtgc
    19741 catgcgtatg gtttcttctg caaaacttgt taaatctgag caagcagctc gtgattttca
    19801 aatttacgcc tcaaaaattc gccagattac tacagattta ttgaaatcag aattaaccat
    19861 aggatctgat aatccgatgt tggtgtctcg tcctgtcaaa aaaacaggct atattgtcat
    19921 cacgtctgat aaaggacttg ttggaggtta caattcaaaa atcttgaaat ctgttatgga
    19981 tatgattaca gagtaccatg ctgatggtga ctatgaaatc atttctattg gtagtgttgg
    20041 ttcagacttc ttcaaagcaa gagggatgaa tgtggctttt gaacttcgtg gacttgcgga
    20101 tcaaccaagt tttgaacaag tgagacaaat catttcacaa tccgttgaca tgtttgtcaa
    20161 tgagattttt gatgagttat atgtctgtta caatcaccat gtgaatagct taaccagcca
    20221 agtccgtgtt caacagatgt tgccaatttc tgacttggtt gctgatgaag cagcagaaga
    20281 aggtgttact gggtttgaat tggaacctaa tcgtcatgat attttagatc aattgttacc
    20341 tcaattcaca gaaagtttaa tttatggggc tatcattgat gctaaaacgg ctgaacatgc
    20401 agcaggtatg actgctatgc agacagcgac agataacgct aagaatgtca ttaacgattt
    20461 gaccatccaa tataaccgag ctcgtcaagc agcaattaca caagaaatta ctgaaattgt
    20521 tgcaggagca aatgcactag aataaaaaat aacgctgact agcgattagg ttattgtcag
    20581 cattcaattt tatcaatcga gataaaatga cttatgggac ttttctattg aaagactgct
    20641 cttttcagta taaaagaagt tagcaagact aactaagccc tgactatcga atataaggag
    20701 aaataaatga gctcaggcaa aattgctcag gttgttggtc cagtagtaga cgttatgttt
    20761 gctagtgggg acaaacttcc agagattaat aatgcattga ttgtttataa agatagtgat
    20821 aaaaagcaaa aaatcgtcct tgaagttgct ctggaacttg gtgacggtat ggtgcgaaca
    20881 atcgctatgg aatcaactga tgggcttaca cgtgggttag aagttcttga cactggtcgt
    20941 gcgattagcg taccagtagg taaagaaact ttgggacgcg tctttaatgt acttggagaa
    21001 accattgatt tggaagaacc atttgcagaa gatgttgacc gtcagccgat ccataaaaaa
    21061 gcaccatcgt ttgatgagtt atcaacatca tcagaaattc ttgaaactgg tatcaaggta
    21121 attgaccttc ttgcccctta ccttaaaggt ggtaaagttg gacttttcgg tggtgccgga
    21181 gttggtaaga ctgtccttat ccaagaatta atccacaata tcgcccaaga acacggaggt
    21241 atttcagtat ttaccggtgt tggtgagcga acacgtgaag gaaatgacct ttactgggaa
    21301 atgaaagaat caggcgttat tgagaaaact gccatggttt ttggtcagat gaatgagccg
    21361 cctggggcac gtatgcgtgt agcccttact ggtttaacca ttgctgagta tttccgtgat
    21421 gtagaaggcc aagatgtttt gctctttatt gataatatct tccgtttcac tcaggcaggt
    21481 tcagaagtat cagccctctt aggccgtatg ccttctgctg ttggttacca accaacactt
    21541 gctactgaaa tggggcaatt gcaagaacgg attacgtcaa ctcaaaaagg ttctgttaca
    21601 tctatccaag cgatttatgt accagcagat gattatactg accctgcgcc agcaacagca
    21661 tttgctcact tggattcgac aactaacctt gaacgtaaat tgactcaaat gggtatttac
    21721 cctgcggttg acccattggc ttcaagttca cgtgctttat cacctgagat tgttggtgaa
    21781 gagcactatg ctgtggcaac agaagttcaa cgtgtgcttc aacgctaccg tgaattacaa
    21841 gatattattg ctattttggg gatggatgaa ttgtcagatg aggaaaaaac attggttgga
    21901 cgtgcgcgtc gtatccagtt cttcctctca caaaatttta acgttgctga acaatttacc
    21961 ggtcttcctg gttcttacgt gccagttgct gagacagttc gcggctttaa agaaattctt
    22021 gaaggaaaat acgatcacct tccagaagac gcctttcgtt cagttggtcc aattgaggat
    22081 gtgattaaaa aagccgaaaa aatgggcttt tagtgaggtg atgccatgac acaaatgact
    22141 gttcaagtgg taacgccaga tggaatcaaa tatgatcacc atgctaaatg tatttctgta
    22201 acaacaccag atggggaaat ggggatttta cctaatcaca tcaatttaat tgcacctttg
    22261 caagtccatg aaatgaaaat tcgccgaggt ggtgaagatg aaaaagtgga ctggattgct
    22321 atcaatggtg gtattattga aatcaaagat aatgtggtta ccgttgtcgc tgattctgca
    22381 gaacgtgacc gtgatatcga tgtcagccga gcagagcgag caaaactaag agcagaacgt
    22441 gaaattgcac aggctgaaac gacccacaac attgatgaag ttcgtcgtgc caaggttgcc
    22501 ttgcgccgcg ctttgaatcg tatcaacgtt agtaaaaaat aagtggtgtt gataaaagac
    22561 aaggataagt aagaaaggtt tttaacctat tattttgttt gctgattctt tttaacatca
    22621 gtttctgaga gtttgaccat actaccttct ctaaacacgt tattattgtt gagagaagtt
    22681 atatggggga actctttttt gtatccacgt tattagtaga aactcagtaa tgacgcttaa
    22741 tatattttta ggctatcaac ttagtcagag aagatgtcaa cttaattgat aagttggacg
    22801 gatcaagatg gtatgttata ataatcctat ggaattatta atgaagatca ttgccttttc
    22861 gtgtcattta ttttttattg gccttagtta ccaattattg attagtgtga ttgactggac
    22921 aaaatttagt cattatcatc cagaaaatct tggccggcta cgactttttg tctttttatt
    22981 agctactgcc ctagggtatt tggtgagcca ttgtatgctg gaattgcttc aaattagcca
    23041 gacgctcttt tttgagttcc gctaatactg gaataaaaga agtatggtat aattttacta
    23101 cgactaagag atagataagg gagaaaattg tggataaaat aatcattgaa ggtggtcaaa
    23161 cacgcttaga aggagaagtt gttattgagg gtgctaaaaa cgcagttctt cctttactgg
    23221 cagcatctat tttaccttca aaaggaaaaa caattcttag aaacgttcct attctatctg
    23281 atgtttttac tatgaataac gtggtacgtg gtttagatat tcgtgttgat tttaatgaag
    23341 cagctaacga aatcacagtt gatgcctcag gacacatttt agatgaagcc ccttacgagt
    23401 acgtgagcca aatgcgtgcc tctattgttg ttttaggacc aattttggca cgtaatggcc
    23461 acgcaaaagt atcaatgcct ggaggctgta cgattggcag taggcctatt aatttgcact
    23521 taaaaggatt agaggctatg ggggcaacga ttactcaaaa aggtggagat attaccgctc
    23581 aagcagatcg actgcaaggt gccatgattt atatggactt cccatctgta ggagctaccc
    23641 aaaacttgat gatggctgcc actttagctg atggtgtgac cactattgaa aatgctgctc
    23701 gtgagcctga aattgttgat ttagctcaat ttttgaataa aatgggagct agaattcgtg
    23761 gtgctggaac agagacgtta acgataacag gcgtcacaag tcttcatggg gtggagcacg
    23821 atgtggttca agaccgtatt gaagcaggta cttttatggt tgcagcggcg atgacttcag
    23881 gcaatgtttt gattagagat gctgtttggg aacataatcg tccattgatt tcaaaattaa
    23941 tggaaatggg tgtttctgta acagaagaag aatatggtat tcgcgttcaa gcaaacacgc
    24001 caaagctcaa acctgtaacg gttaaaacct tgcctcatcc aggttttcca acagacatgc
    24061 aagctcaatt tacagcttta atggcagtgg tcaatggaga gtctactatg gttgaaactg
    24121 tctttgaaaa tcgatttcaa catctggaag aaatgcgacg catgggctta caatctgaaa
    24181 tccttagaga aactgccatg attcatggtg gaagacaact gcaaggtgct cctgtgatgt
    24241 caacagattt acgtgccagt gctgccctta tcttgacagg gattgttgct caaggagtta
    24301 caatagttaa taatttggtt catttagatc gtggctacta tcaatttcat gaaaaattag
    24361 caaagcttgg agctactatt agtcgtagca gtgaggtcta gcttatgaca aatggtttaa
    24421 aatatgtctt agaacaaatg ttattacttt tagtaattgc tgccttggcg tgtctttttt
    24481 tagctattgg acttatgatt ggttatagtt ttatgggaga tggccatagt ccatggcata
    24541 ttttatctat ggataagtgg gcagagttag tgaataaatt tactggaaag taggccttgc
    24601 ctacttttta tagcatttga gaggaagtat gttaacaagg aaaaaacgaa aaagggtgct
    24661 taattccttc ttattgattt tgttagtgtt ggggtctaac tgccttgcta agagtgattt
    24721 catagctagc aatcatccta tcaagcaact ttatcagact cttgttgggg agaagaaaaa
    24781 atcattactc acacataata atttgcccgc tgatgttccc acagaagctc tggcggcatc
    24841 ggtattaaca ccatcaatca aaaagcaact aggtccaaat gttcagtgga atggagcagg
    24901 cgcctatatt atcaacagga acaaaacaga tttaactgct aaggtagcca gtccgcctta
    24961 tgccaacaat gaaaccaaat gggtgcaaga gcaaaaggtt cctactagag ctaatgcctt
    25021 acttactaag tcgacacgac agtatcgaaa tcgctatcaa acgaacaatg cttatcgtac
    25081 ctttaagcca gcaggttggc accgattgca ccacttaaaa ggaagttatg atcacgcggt
    25141 tgatagaggg catttgctag gttatgcttt agttggtgga ctgaaaggtt ttgatgctta
    25201 ccagtaatcc tgataatatt gccactcaac taagttgggc taatcaagta aataaaccct
    25261 actcgacagg tcagaactac tatgaaggtt tagtacgtcg tgctttggat aaggggcatc
    25321 gcgtccgcta ccgtgtcacc ctactttatg atggtgataa tctactagcc agcggtagcc
    25381 atttggaggc taaatcctct gatgacagct tgacttttaa cgtgtttgtt ccaaatgtcc
    25441 aaccaggatt gaccgttgac tatcggacgg gacaaatagc tatcaatctc taagcgaaaa
    25501 gtcactgatt taagattgtc actaagcact ttttttgata gaatagaact aattgaataa
    25561 gtgtctatga gactagtact aatagagaaa ttaacaggga gtgagggccg tgactggaag
    25621 ccttcttaag ggaactatta ggaattcact cagctaaaga caattaatta aggtctgata
    25681 acatcagata aaaacggatg gtaccgcgtg tcaacgctcc gcttatcaag tggaggagtg
    25741 gcacgctttt ttcatcgcta aaagaaggga aaactatgga tttacaagca caattagagg
    25801 aattaaaaac aaaaacattg gagaccttac agcctttgac gggtaatcat accaaagaac
    25861 tgcaagattt gcgcgtggct gttcttggga aaaagggatc tttgacagaa ttactaaagg
    25921 ggttaaaaga cttgtctaat gacttgcgtc ctgtggttgg taaacaggtg aacgaagttc
    25981 gtgacttatt gacaaaagcc tttgaagaac aggctaaaat tgtagaagcg gctaaaattc
    26041 aggcccaact tgatgctgaa agcattgatg tgactttacc gggtcgtcaa atgactctgg
    26101 ggcatcgtca tgtgttaaca caaaccagtg aagaaatcga agatattttc ttaggaatgg
    26161 gttttcagat tgttgatggc tttgaggtgg aaaaagatta ttacaacttt gagcgcatga
    26221 atttgccaaa ggatcaccct gcccgtgaca tgcaagatac gttttatatc acagaagaaa
    26281 tcttgttacg gactcacacc agtcctgtgc aggcccgcac acttgatcaa catgattttt
    26341 caaaagggcc tttaaaaatg gtttctccag gtcgtgtttt ccgtcgagac accgatgatg
    26401 ctacccactc acatcaattc catcaaattg aaggtttggt tgtgggcaaa aatatttcca
    26461 tgggagacct caaagggact cttgaaatga tcatcaagaa gatgttcggt gaagaacgta
    26521 gcattcgttt gcgcccgtca tatttcccgt tcacagaacc atctgttgaa gtggatgttt
    26581 cttgctttaa atgtggtggg aaaggctgta atgtctgcaa gaaaacagga tggattgaaa
    26641 ttcttggtgc tggtatggtt cacccaagtg tattggaaat gtcaggtgtt gatgcaaaag
    26701 agtattcagg ctttgccttt ggtttaggtc aagagcggat tgccatgttg cgttatggca
    26761 ttaatgacat tcgtggtttc tatcaaggcg accaacgttt ctctgagcaa tttaactaaa
    26821 acgagtcgtt tgaagacctc tgtcagctat tttatctaag attgagtgaa agttgatagg
    26881 taatgataat aggttaattg tctaagggga aagtccctct cgcttcaacg tcataagggt
    26941 tttgacttgg aacttaaaat acgaaaggaa atgactcaaa tcacggcttg agagccttct
    27001 ctagccgagt gatttgggca ctaaaattat gttagtatct tataaatggt taaaagaatt
    27061 agtagatatc gatgtgacac cagcagcact tgctgagaaa atgtcgacaa cgggtatcga
    27121 ggtagaagga attgaagtcc ctgcagaagg tttatcaaaa ctggttgtgg ggcatgtgct
    27181 ttcttgtgaa gatgtgccag agacacattt gcatttgtgt caggtagata caggtgatga
    27241 aacgccacgt caaattgtgt gtggcgcacc aaatgtgaaa gcagggatta aggttatcgt
    27301 ggctgtgcca ggtgctcgta ttgcggataa ctataaaatc aaaaaaggca aaatccgcgg
    27361 catggaatct cttggtatga tttgttcctt gcaagaactt ggtttgtcag atagtatcat
    27421 tccaaaagaa ttttcagacg gtattcaaat cttgccagag gaggctgtgc caggtgatgc
    27481 tatttttaaa tacctggact tggacgatca tatcattgga ttgtccatta cacctaaccg
    27541 tgctgatgcg ctttctatgc gaggtgtggc acatgaagtc gcagctattt atggcaagtc
    27601 agtatcattc cccccaaaaa atctacaaga atctgataag gcaacttcag aagccattga
    27661 agtggccatt gcctctgata acgttctaac ttacgctagc cgtgtcgttg aaaatgtcaa
    27721 agttaagcca agtccacaat ggttgcaaaa ccttttaatg aatgccggta ttcgtcctat
    27781 taataatgtg gttgatgtga ccaactatgt gctcttgtat tttggtcaac ctatgcatgc
    27841 ttttgattat gataaatttg aagaccataa gattgtggcg cgtgcggctc gtcaagggga
    27901 aagtttagtc acacttgatg gtgaaaaacg ggatttgacc actgaggatc ttgttattac
    27961 cgtggctgac aaaccagttg ctttggcagg tgttatgggt ggtcaagcca ctgaaattga
    28021 tgccaactct cagacggttg ttcttgaagt tgctgttttt gatggcaaat cgattcgtaa
    28081 aaccagtggt cgtttaaacc ttcgttcgga atcctcttca cgttttgaaa aaggggttaa
    28141 ctatgcaact gttttagaag cgcttgactt tgcagcggct atgttacaag aattagcaga
    28201 aggtcaagtc ttatcaggcc atgttcaagc tggacaattg ccaacagaac ctgttgaagt
    28261 ctcaactagc cttgactatg tgaatgttcg tttaggaaca gaattaactt ttgctgatat
    28321 tcaaaggatt tttgaccaac ttggatttgg tctaacagga gatgaaacaa gcttcacggt
    28381 agctgttcct cggcgtcgtt gggatgttag catcccagct gacttggtgg aagaaattgc
    28441 gcgtatctat ggttatgata agttgccgac aaccttacca gaggcagggg gaacggctgc
    28501 agaattaacg ccaacacagg ctcttcgtcg taaagtccgt ggtttagcgg aaggattggg
    28561 cttgactgaa atcatttcgt atgccttgac aacaccagag aaagctgttg agtttgcagt
    28621 ggcaccaagt cacctaacag aactcatgtg gccaatgtct gtggaacgtt cagcgcttcg
    28681 tcaaaatatg atttcaggga tgctagatac ggttgcctat aatgtggctc gtaaacaaag
    28741 taacttggct ctttatgaaa ttggaaaaat ctttgaacaa gaagctaatc caaaagaaaa
    28801 ccttcctaat gaagtgaacc attttgcttt tgctatttgt ggcttagtgg cacaaaaaga
    28861 tttccaaacc caagctcagg cagtggattt ttaccatgct aaaggtatct tggatacttt
    28921 atttgcaaac cttaacctca aggttcaata tgtgccaacc aaagacctag caaacatgca
    28981 cccaggacgg acagcgctta tcctattaga tgagcaagtg attggatttg ttggtcaagt
    29041 tcatccagga acagcaaagg cttatagtat tccagaaacc tatgtggcag aattggatat
    29101 ggctgcttta gaagcagcgt tgtcaagtga tcaaactttt gtggagatta ccaaattccc
    29161 tgctatgaca cgtgatgttg ccttgttact tgaccgtgaa gtgagtcatc aggccattgt
    29221 aacagctatt gaatcagcag gtgtaaaacg cttgactaag attaagctct ttgacgtgta
    29281 tgaaggagta actattcagg ctggcaaaaa atcaatggct tatagcctta atttccaaaa
    29341 tccaaatgac aatttaacgg atgaagaagt tgctaaatac atggagaaaa tcaccaaagc
    29401 attgacagaa caagtcggtg ctgaagtacg ctaagaaaaa aactgggcct ctaaggctcc
    29461 gtttttttct gttataatag aggaaaaaag aactccagtt caaatgattg gagaaaaaca
    29521 tcagaaggtg gaggaaaatc agaatgtatc aaacaaaaat aacaggcaac cgcctttacc
    29581 acacggtttc gaaaggctac ggagatagtg tgaccttatt tggaaaaact gatcaagggg
    29641 aaacccctat gagtttactg gttattgcct tgtcttcttg tgtgactatg tgtgtgcagg
    29701 gtttttacca tcgtcaattt cagcaagaca cacttgctgt ttctgttgag gctagttatg
    29761 aggaagaagt ttttgaacta cttgttagga ttgatgatgt tttagatgac aaaaagaaag
    29821 ctgatttatt ggcttacatt ggaacttatt gtcgtgtgaa acaactcctc aaacctgaag
    29881 ttacggtgac cattacgttg gaaggactgt ctcatgtctg atgctagttt gaaaacttac
    29941 caaaaacaat gggcttatca aaagtattgg gtcatggcac actcacagca gcattacaat
    30001 gctttaagag aattgtttaa aggaaatcag tggtcagaag aaaaggtgtt gacttttcat
    30061 tgtttgattg aagaagcgca agccattcct cccacagtaa aaagcttacg aacagcatat
    30121 cagcatgttt gggggtattt taaaaaggta gcgagtcagg aagaaaaaaa acatttcaaa
    30181 gatttggatg ctcagttgga aactaaatct gaggagatgc tatgcttttt acaagagatg
    30241 actgctcatt atcagccctc ttatctgcta tcttgccgtt tgattaccaa aggtccttaa
    30301 atgctaaaca gaaaagtagg gatttctggg aagttatgct aagctagtga tataaataag
    30361 ggggaatgag agatgttttt agcgcttaat gaaatgaaac aatccaaatt gcggtatggt
    30421 ttgattgctg gtttgctatg tttggttgcc tatttgatgt tctttttgtc aggattggcc
    30481 tttggtttga tgcaggagaa ccgctcggcg gttgatcttt ggaaagctga cagtgtttta
    30541 ctagccaagg atgctgacgc taccttgacc ttatcacagg tgtccagagc tcaagaaaat
    30601 caaataacag cagacaaggt agctcctctt gctcaactca ataccgtggc gtggtcagtt
    30661 aaaaatccta aggatgccga caaagttaag gttagccttt tcgggattga ttctaatagc
    30721 tttattcgtc ctaacattgt aaaaggtcga ttatttaaga ctaacaaaga ggttgttttg
    30781 gatcaaagcc ttgcaaaaga ggaagctttt gcgattggca aggactttta cacatcgagt
    30841 tctagtcaag cattaactat cgttggttat actcaaaatg ctagatttag tgttgcacca
    30901 gtggtttata tgaatttgga agcttttgaa acattaaaat atggaggacc actaccaaaa
    30961 gataagcaag ttgttaatgc ttttatcact aaaggaagtt taacagatta tcctaaaaaa
    31021 gacttccaaa aattagatat taaaaccttt attactaaat tacctggtta tagcgctcaa
    31081 cttttaactt ttggctttat gattagtttt cttgtcatta tttcagctat tattattggt
    31141 atttttatgt atattttgac tattcaaaag gcacctattt ttgggattat gaaagcgcaa
    31201 ggaatttcta acaaaacgat tacgaccgct gtgcttatgc agacattctt tttgagtttt
    31261 ttaggtagtg gtttagggtt gctaggtact tggctgacat cattattatt accaacagta
    31321 gtaccttttc aaagcaattg gtttttgtat ttggctatat tcgttagtat gatctgtttt
    31381 gctctattag gcaccttatt ttctgttttt aacattatac gaattgatcc tttgaaagca
    31441 attggatagg aggtagtgat gtcggtttta acatttaaac aagtgaccaa aacatttcaa
    31501 gatggtcatc acgaaatcaa cgcattaaag gcaactgact tttccattga agctggagaa
    31561 tttgtggcta ttattggacc atcaggttct ggaaaatcaa cctttttgac cattgctggt
    31621 tgcttacaga ccccaagttc tggtcagcta atcattgatg gcactgatta tacgcattta
    31681 tcagaaaaag agcgctcacg cttgcgcttc aaatccgttg gttttatctt acaagcttcc
    31741 aatctgatac cttttttaac ggtccagcag cagttggaat tggtcgatca tttgacagga
    31801 agcaaagaaa aagccaaagc caatcagtta tttgacgatt taggcattac agggctaaaa
    31861 catcagttac ctcaagaatt atccggcgga gaaaggcaaa gagcggctat tgcccgtgct
    31921 ctttaccatg atccagcact gatattggca gacgaaccta ctgcaagttt ggatactgaa
    31981 aaagcctatg aagtggtcaa actgttggct aaggaaagta aagaaaaaaa caaggccatt
    32041 attatggtca ctcatgatga tcggatgcta aaatattgtg acaaagtcta tcggatgcaa
    32101 gatggagagt tatgtcaaga gagatagtag actggtaaga gtttatgata ttagaaaaaa
    32161 accaaacaag cacagcactt gtttggtttt tttctaagtg tgactattat caatacgtca
    32221 ccatttccct aaagcttact atacgggatg ctaaaggtat caccatgctc aaagtcgcca
    32281 tattggtaac ctcggtcaaa ccaacgttgg cgttgcttag aagtgccatg tgtaaaacta
    32341 tcaggaacgg ttctgccata ggtttcttct tgcagagtat catccccaac tgcgtgagct
    32401 gctgccattg cctcctcaat gtctcctttt tccaaaaggc cttgcccttg aacataatta
    32461 gcccaggcac cagcatagta atcagcttgt aattccaact tgacgttgag ttgattggct
    32521 ttagcctttg attttccttg tctagcgcta gcgtaattat ccataattcc caattcattt
    32581 tggatgtggt ggccaacttc atgagcaatc acataggcca tagcaaaatc accttttgcg
    32641 ccgtacttgg ttgatagttc attataaaaa gaaatatcta aatacacttt ttgatcgcct
    32701 gggcaataaa aaggaccaga agaggcttgc cccctgccac aagcggtttg agttgctcca
    32761 gtatatagaa ctaatgttgg tttatgataa gttaaccctt tctcacgaaa tgtcttagtc
    32821 caatagtcct cggtagaggc gaagacctta ctgacaaaag aaacctgttc ttgactagcc
    32881 ttgtcaccat ttgtacgcgt tacttggctt gattgatagg cattgttgtt ggtagaagaa
    32941 ggcttgcctc ctaaaacacc agataggcca cctcctccca taactaggag aaggagaaga
    33001 ataaccagct tggttttcca acctcctcgt gaaaagagta attgaagcag gagaccgccc
    33061 cctaggccgc cgcccccaaa agaaccagac gattgaccac gtctatcttc aacctgttga
    33121 ctttctctca aatcatctgt tttcataagt ttctcccatc tatttcttga ttttattata
    33181 aaataattct attagaattg ctatttttat gatgagatta taactaaaaa taggaaaagc
    33241 aataggtatt tgctataata taacaagggt agattcagtt tgtataaagg agtcatatga
    33301 aattaattta cacagagatg agttactcga tgacagagat tttggtgaat gaagcacgaa
    33361 aagctgctga ccaaggttat cgagtgttct atattgctcc aaattctctt tcatttgaaa
    33421 aggaaagaga agtcttaacc ttattgcctg aacgagggac tttttcgata atagtcaccc
    33481 ggttcgttca aatgtcaagg tattttacag ttgagagctc tccttctaag caacatctag
    33541 atgacacgac tttggctatg attttttatc ggaccttgat gcaattaaaa ccagaagatt
    33601 tgccgagtta tggtcgtttg caaaataatt cggtttttat tgaacaacta gttgagttat
    33661 ataaggaatt aaaaaacgca caattaagcg tacatgattt aacagggtta gaccatcctc
    33721 aaaaacaaga agatcttatt aaaattattg agcttgcaga gacgatcatg attcagcaag
    33781 attataatca agatagtcct ctacaatctt ttgcaagagc aattaagtta ggacttttaa
    33841 ataaccaact atcaaaaaca gttgttgtta ttgatggttt ttcacgtttt tcagctgaag
    33901 aggattattt attatcactt ttaaataaca actgtcaaga ggtcatcatt ggcagttatg
    33961 tgagtcaaaa agcttatcaa aaatctttta ttaagggaaa tatctatgag gctagccttc
    34021 attttttgca agatttggct caaaaatacc atatcaagcc ggtatttgca acctctaatc
    34081 aagtgtttaa accagccttt tcacggctaa cacaattatt tgaagcaact catgattttt
    34141 cacaagtaga ctggcaactc caaaagaatg atcttgatca ctttagcctt tggcaatgtc
    34201 atcatcaaaa agaggaaatt gaacatgtag caaaatccat tcggcaaaag ctatatgaag
    34261 gttaccgtta taaggatatc ttagtgttgc taggagatat ggatgcttat caattacaaa
    34321 ttgggcctat ctttgataag tttgaaatcc cctactattt aggaaaagca gagcctatgg
    34381 ctgcccatcc attagtccaa tttatagaat cgctcgaacg aagtcagcgc tataattggc
    34441 gtcgtgaaga cattttaaac atgttaaaat caggactttt tggttgtttt gatgatagtg
    34501 atattgatcg ctttgaggaa tatactcagt ttgcagatat taaagggttt actaaatttt
    34561 caaagccttt taccattaac tcttctaggc agtatcctct tgacttttta aatgaaatga
    34621 gacaagacat cgttttacct ttgcaagaat tgtttaagag tcaaaaacaa cttggtgctt
    34681 cacttgttga caaattaata ctttttttaa aaaagattag attagctgag aatatgcaag
    34741 gtttagcaca gtcccaatta gaggtggaaa aaaacgaaga agtttggaaa aggtttacag
    34801 atattttgac ttcttttcat catatctttg gtcaagaaaa attacggcta tcagattgcc
    34861 ttgctttaat caaaacggga atgaaatcag ctcagtatcg tgttgttcca gcgacattag
    34921 atgttgtcac tattaaatct tatgaccttg ttcaaccaca ttcaaaacct ttcgtttatg
    34981 caattggtct aactcaatca cattttccta agcaaattca ccattcagga ctactttctg
    35041 atcaagagcg tgctagaatt aatgaaataa gaaattatcg tcattttgat attgctagtg
    35101 ccgaaaatag taaaaaaaac catcaaactg cgttatctct gtttaatgct gctactaaag
    35161 agttagttct tagtgttcca acggtaatca acgagacatt cgatgatcta tctccttatc
    35221 ttaaagaatt aataaacttt gggttacctc ttttggataa aggcaaaaac tatctatctt
    35281 atgataatag cgatattgct aactataaag ctctcttgtc acaaattatt gctattaacc
    35341 gacaagatct tatagaaatg tcagatcaag ataagatgtt ttggactgtt gtcttacgtt
    35401 atctcaggaa acagttaaga aagcaacagc tagagctacc tacttcagat tatcgtttat
    35461 caacaaagcc tttgtctaaa gaagttatcg aggtatgttt tccaaaggga atccctttaa
    35521 agctatctgc aactgcttta accgtttttt ataataatca gtacaactat tttttgaaat
    35581 atgttttaaa tttaaacaaa acagaatcca ttcacccaga ttccagaatt catggtcaat
    35641 acttgcatcg tgtctttgag cggttaatga aagatcacac gcaagaaccg tttgataata
    35701 agttaaaaca agcaatctac cataccaatc aagaaagttt ttttcagcag gtttaccaag
    35761 ataatgccga ggctgagtac agtttagcta tactagaaga tattgtcaga tcaacagcac
    35821 ctatcttgca acttaaccaa aacatacagg tcattgatca agaaaagaac tttcagctgg
    35881 atatgggaaa tgagatatta gtccacggga tcattgatcg tattgaccag ctgagcgacg
    35941 gtagcttggg cattgttgac tataaatcaa gcgcgaatca atttgatatt gggacctttt
    36001 ataatgggtt gagtccacaa ctagtgactt acctcgcagc cctaaaacag atcgcaccgc
    36061 acgatataaa ccaattattt ggggctatgt accttcattt gcaagatcct aaattggatc
    36121 tagtaacatt taaacaaatt gataacacat tagtggagag tatctataaa gcgttgacct
    36181 ataaaggtat tttttcagaa gtcgaaaaag agcatctatc tactggtgct taccaaacca
    36241 aaaatgctct ttattccaat gacgaattgg aaacactttt aaattataac aagtacctct
    36301 atcttaaagc tgctaaacac attaaaaagg gacatttttt gattaatcct tatacaagcg
    36361 atggtaagac agttcaagga gatcaattaa aagccattac ccgttttgaa gcagatcttg
    36421 acatgggaca ggcaaggcga ctagtgactc tccctgctaa ggagaaaaaa gagtgctttt
    36481 taacattaat gagaaaggag agccacttgt gatttctttt gccccatttt taagccccga
    36541 agctattaaa catttacaag aaaacgaaag gtgcagtgat cagtctcaaa aacgcacagc
    36601 tcaacaaatt gaagcaattt atactagtgg ccaaaatata cttgtatcag cttctgctgg
    36661 ttcaggaaaa acctttgtaa tggtcgaacg catacttgat aaaattttga gaggtgtttc
    36721 aattgatcgg ctttttatct caacctttac tgttaaagca gctacagaac tgcgtgaacg
    36781 gattgaaaac aaattatact cacaaattgc tcaaactaca gattttcaaa tgaaagttta
    36841 tttaacagaa caattgcaat ctctttgtca agctgatatt ggtactatgg atgcttttgc
    36901 acagaaagta gtaagtcgct atggttatag cattggcatt tcatcccaat ttcgtatcat
    36961 gcaggataaa gcagaacaag gtgttttaaa gcaagaggtg tttagcaaac tctttagtga
    37021 gtttatgaat caaaaagagg caccggtgtt tagggctctt gtgaaaaatt tttctggtaa
    37081 ctgtaaagac acttcagctt ttagagagtt agtttatact tgttattctt ttagccaatc
    37141 gacagaaaat cccaaaatat ggttgcaaga aaattttcta agcgctgcta aaacttacca
    37201 aagacttgaa gatatcccgg atcatgatat tgaactctta cttttggcaa tgcaagacac
    37261 tgcaaatcag ctaagagatg tgactgatat ggaagattat gggcagctga ctaaggcagg
    37321 tagccgatct gctaaataca ctaaacactt aacgatcata gaaaagttgt ctgattgggt
    37381 gcgtgatttt aaatgtttgt atggaaaagc cggattggat cgattgatca gagatgtgac
    37441 aggccttata ccatctggga attatgttac agtctcgaag gtaaaatacc ctgtttttaa
    37501 gaccttgcat caaaaattaa aacaatttag gcatttagaa acaattttaa tgtatcagaa
    37561 agactgtttt cccttattgg aacagttaca agattttgtg cttgcgtttt cagaagctta
    37621 tttagctgtc aaaatacaag aaagtgcttt tgaattttca gatattgcac actttgcaat
    37681 caaaatttta gaggaaaata cggatattcg ccaatcctat cagcaacact atcatgaggt
    37741 gatggttgat gaatatcaag ataacaatca tatgcaagag cgactcctga ccttactatc
    37801 gaacggtcat aatcgcttta tggtaggaga tatcaaacaa tcgatctatc gatttcggca
    37861 agccgatcct cagattttta atcaaaagtt tagagactat caaaaaaaac ctgagcaggg
    37921 gaaagtgatt ttactcaaag aaaactttcg tagccaatca gaggtgttaa atgtcagcaa
    37981 cgctgttttt agtcacttaa tggacgaatc agtaggagac gtcttatacg atgagcaaca
    38041 tcagttaata gcaggtagtc atgctcaaac agtcccctat ctagaccgtc gtgctcagtt
    38101 attgctatat aatagcgata aagatgatgg caacgcccct tcagatagtg agggtatttc
    38161 atttagcgag gttacaattg ttgccaaaga aattattaag cttcacaatg ataagggtgt
    38221 cccttttgaa gacattacgt tactcgtttc ttcaagaaca agaaatgata tcatttctca
    38281 tacattcaat caatatggta ttcctatagt aacagatggt gggcagcaaa actatcttaa
    38341 atctgttgaa gtgatggtta tgttagatac attacgcacc attaataacc caagaaatga
    38401 ttatgccctt gtggctttac tgcgctcacc gatgtttgcc tttgatgagg atgatttagc
    38461 aagaatagca cttcaaaaag acaatgagct agataaagat tgcctatatg acaagataca
    38521 aagggctgtg attggaagag gtgctcatcc tgaattgatt cacgatacct tgcttggcaa
    38581 gttaaatgtt tttttaaaga cgttgaaaag ctggcgtcga tacgctaagc tagggtcgtt
    38641 gtatgacttg atttggaaaa tttttaatga tcgtttttat tttgattttg tagctagtca
    38701 agcaaaagca gaacaagcac aagctaatct atacgcatta gctctacgtg ctaatcagtt
    38761 tgaaaaatcg ggctataaag ggctataccg ttttattaaa atgattgata aggtacttga
    38821 gacgcaaaat gacttagctg atgtggaagt ggctgctcct aaacaagctg ttaatttaat
    38881 gaccattcac aagtctaaag gtttacaatt tccgtatgta tttatcctta attgtgacaa
    38941 gcgcttctca atgacagata ttcataaatc atttattctg aatcggcagc acggtatcgg
    39001 tatcaagtac cttgcagata tcaaaggttt acttggtgaa acaacactca attctgttaa
    39061 agtaagcatg gaaaccttac cttatcaatt gaacaaacaa gagttgcgct tagcaacttt
    39121 atcagaacaa atgcgcttac tgtatgttgc tatgacacga gctgaaaaaa aagtttattt
    39181 tattggtaaa gctagtaaga gcaaaagtca agaaatcaca gatcctaaaa agttagacaa
    39241 acttttgccg ctggctttac gagaacagtt attgacattc caagattggc tattagcaat
    39301 agcagatata ttttcaactg aagatcttta ttttgatgtt cgctttattg aagatagtga
    39361 tttgacacaa gagtcagtcg gacgacttca aacaccacag ttattaaatc cagatgatct
    39421 taaagataat cgtcaatcag aaacaattgc acgggcttta gatatgttag aagcagtgtc
    39481 tcaattgaat gccaattatg aagcagctat tcatttgcca acagttcgaa cgcctagcca
    39541 acttaaggca gcttacgagc ctttattaga acccattggt gtagatatta tagagaaatc
    39601 ttctcgatcg ctatctgatt ttactttgcc acatttttca aaaaaagcaa aagttgaagc
    39661 aagtcatatt ggatcagctc ttcatcagtt gatgcaggtg ctccctttgt caaaaccgat
    39721 aaatcaacaa acgcttttag acgctttaag aggaattgat agtaacgaag aggtaaaaac
    39781 agctcttgat ctcaaaaaaa tagagtcgtt cttttgtgat acaagcctag gccaattttt
    39841 tcagacttac caaaaacact tgtatcgaga agcaccattt gctattttaa aagttgaccc
    39901 tattagtcaa gaagaatatg tcctacgtgg tattatagat gcctactttt tgtttgatga
    39961 tcatattgta ttagtggact ataaaacaga taaatacaag cagcccattg agttaaaaaa
    40021 gcgttaccaa caacagttgg agttatatgc agaagctctc actcaaacgt ataaacttcc
    40081 tgtgactaag cgctatcttg ttttaatggg aggtggaaag ccagaaattg tcgaagttta
    40141 aggttgttgt gacacaaggg tattttgcaa atgataatag tagagttgag gattttacga
    40201 aatgcttgaa aagctattga cctttgaata ataatacaat ataataagtt ttattagcga
    40261 caaaaaggaa taaatatact atgaatttta aaaaaataag atttggtttt ttgctttgcc
    40321 tcctacttta tcctttagca gcctgtaaca agtctgaaca acttaatcac tacgaaagaa
    40381 ttaaaaaaac aagaaaatta gtcgttgctg taagccctga ttatgctcct tttgaattta
    40441 aagctttagt taatggaaaa gatactattg ttggagcaga tgttcaatta gctcaggcta
    40501 ttgctgatga attagacgtt gatcttgagc tttcaccaat gagttttgat aatgttttgt
    40561 ctagtttaca gactggtaaa gctgatcttg ctatttcagg aatctcacat actaaagaaa
    40621 gagctaaagt atatgatttt tcaattcctt actatcaggc agaaaacgct atagtgatga
    40681 gagcatctga tgctaaagtg accaaaaata ttagtgacct aagcggtaag aaagtagccg
    40741 ctcaaaaagg tagtatcgag gaaggtttag ttaaaataca attaccaaag gccaatctga
    40801 tttctttgac tgctatggga gaagccatta atgaactaaa agcaggacaa gtctatgcag
    40861 ttaccttaga aacacctgta gctgctggtt ttttagccca acataaggat ctggctttag
    40921 caccctttag cttaaaaacc agtgatggag atgccaaagc agtggccctt cctaaaaata
    40981 gtggtgactt aaccaaagcc gttaataagg ttattgctaa gttagatgag caagaacggt
    41041 acaagtcatt tattgcagag acaatagcac taacgaaaaa tactatgaag taataaggtt
    41101 aataaaaact ttattagtat ccgttggaaa agtgtttgga ataaacaata aaagaggttt
    41161 gacttttttt aaaaaataat gtaatataat tgggaacgtg aaaatgttac aatatcttga
    41221 ggaggtgaaa cacatgtcaa aaacagtagt acgtaagaat gaatctcttg acgatgctct
    41281 tcgtcgcttc aaacgttctg ttactaaagc tggtactctt caagaatcac gtaaacgtga
    41341 attctacgaa aaaccttctg taaaacgtaa acgtaaatca gaagcagctc gcaaacgtaa
    41401 aaaattctaa tggtaaaaaa taaaaacagt tctcacaatt agaactgttt ttatttttta
    41461 tccagaagaa gcaagggagc ttttttgata tcaaaaaaag cagttagaca tgcctaacta
    41521 ctttatcaaa aatcgcctta tttttgagcc aacaaatcac ggatttctgt caataattct
    41581 tcttgagtag gagctgcagc ttctttttct tttttaggca tagctttttc agcggctttt
    41641 acaacaaaga aaagactggt accgatgata agaaaattaa taacggctcc taaaaagcta
    41701 ccatatttaa caccattcca tgacaattga gtgatatttt caacatttgc agctttcaga
    41761 gctgggttta aaataagcgg tgtgataata tcgttcacaa aagaagtgac aatagcacca
    41821 aaagctcccc cgatgataac tgctacagca agttcaataa tgtttcctct aaacaaaaat
    41881 gcttttaatt ctttaaccat taaatattcc cccttttaat atctctaagt taagcatagc
    41941 ataattagta aacaaaatcc aatggaatca cttcagcacg ccaaacgcat gaagaaactt
    42001 ttgttttcag aaaactagat tcataatgac aaaatcaatc aaagtagtac actatagatg
    42061 aggtgactac gatgattgat tttattattt ctattgatga ttgcgcagtt gaattggata
    42121 gtcgtcaatc ttggaaaatt cgctccccct tatcaaccat tctatttctt gtcttcgttt
    42181 gtcagttagc tagcattgaa acctggaagg agatggaaga ttttattgaa atgaatgaac
    42241 cattgtttgc gacctacgtt gatttgagtg aaggttgtcc gtctcatgat accttagagc
    42301 gtgtgattag tcttgttaat tcagaccgtt taaaagagct taaagttcaa tttgagcaat
    42361 cattgacaag cttagatgcc gttcatcaac tgatttcagt ggacggtaaa acgattcga
//
LOCUS       DAUDWO010000015        39478 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.015, whole genome shotgun sequence.
ACCESSION   DAUDWO010000015 DAUDWO010000000
VERSION     DAUDWO010000015.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 39478)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39478)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39478
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.015"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..824
                     /locus_tag="VHC05_000736"
     CDS             <1..824
                     /locus_tag="VHC05_000736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015017481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEQ5402065.1"
                     /translation="GFTDHKEVFAYSAQVACDKYGWALAYSVEAGNIHDSQAFPALFA
                     KLEPLKPQFIIADSGYNIPSIAKFLIDKEITPVLPYTRPRGKKDLLRPKELIYDEHFD
                     CVICPEHQALTYRTTTREGYREYKSDPAICANCPLLSVCTTSKNHQKVVTRHIWKDYL
                     EQCEDIRHQRGMKELYQHRKETIERLFGTAKEYHNLRYTREKGKSKMEDKVGLTLACL
                     NLKKLVKRMAGEPFYFVQMRWFKHGNSHFYLKTLKKTSTKSMFVFNLRACSCKLF"
     gene            858..1088
                     /locus_tag="VHC05_000737"
     CDS             858..1088
                     /locus_tag="VHC05_000737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2969 domain-containing protein"
                     /protein_id="HEQ5402066.1"
                     /translation="MSKKDKKIEIQLIDHKVMVNETRIDGYQLQIGKRVVGEIAELDE
                     KFAVIKNDTVDSFFKTLEQAVENIIENYNLNH"
     gene            1149..1229
                     /locus_tag="VHC05_000738"
     tRNA            1149..1229
                     /locus_tag="VHC05_000738"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1183..1185,aa:Tyr,seq:gta)
     gene            1279..1350
                     /locus_tag="VHC05_000739"
     tRNA            1279..1350
                     /locus_tag="VHC05_000739"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1311..1313,aa:Gln,seq:ttg)
     gene            1477..2682
                     /gene="rpsA"
                     /locus_tag="VHC05_000740"
     CDS             1477..2682
                     /gene="rpsA"
                     /locus_tag="VHC05_000740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002997242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S1"
                     /protein_id="HEQ5402067.1"
                     /translation="MNEFEDLLNSVSEVNPGDVVTAEVLTVDNGQANVVIEGTGVEGV
                     LTLRELTNDRDADINDFVKAGDTVEVLVLRQVVGKDTDTVTFLVSKKRLEARKAWDKL
                     VGREGEVVTVKGTRAVKGGLSVEFEGLRGFIPASMIDTRFVRNTEKFVGQEFDAKIKE
                     VDAAENRFILSRREVIEEAAKEARAEVFSKISEGAVVTGTVARLTSFGAFIDLGGVDG
                     LVHVTELSHERNVSPKSVVSVGEEVEVKVLSIDEEAGRVSLSLKATTPGPWDGVEQKL
                     AQGDVVEGKVKRLTDFGAFVEVLPGIDGLVHISQISHKRVENPKDVLSVGQEVTVKVL
                     EVNAADERVSLSIKALEERPAQAEGDNKEEKRQSRPRRPKRESRRDYELPETQTGFSM
                     ADLFGDIEL"
     gene            2795..2866
                     /locus_tag="VHC05_000741"
     tRNA            2795..2866
                     /locus_tag="VHC05_000741"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:2828..2830,aa:Arg,seq:ccg)
     gene            complement(3230..3532)
                     /locus_tag="VHC05_000742"
     CDS             complement(3230..3532)
                     /locus_tag="VHC05_000742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402068.1"
                     /translation="MTYELCLEYGTYPLSRVDAYWGEDQNPPTFIQEDRLLCHKLETM
                     NHLFHDLFVTIESQFHYVGFNMPEKRAQIRILYQEVATILKSKYKDYPIKIETFLL"
     gene            3734..4720
                     /locus_tag="VHC05_000743"
     CDS             3734..4720
                     /locus_tag="VHC05_000743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-related sulfurtransferase"
                     /protein_id="HEQ5402069.1"
                     /translation="MSEKIRVLLYYKYVSIENAQEYAAKHLEFCKSIGLKGRILIADE
                     GINGTVSGDYETTQKYMDWVHSDERFADLWFKIDEENQQAFRKMFVRYKKEIVHLGLE
                     DNNFDSDINPLETTGEYLNPKQFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRN
                     FRELPQWVRDNKDKFMEKRVVVYCTGGVRCEKFSGWMVREGFKDVGQLHGGIATYGKD
                     PEVQGELWDGAMYVFDDRISVPINHVNPTVISKDYFDGTPCERYVNCANPFCNKQIFA
                     SEENETKYVRGCSPECRAHERNRYVQENGLSRQEWAERLEAIGESLPEFVGA"
     gene            4791..4982
                     /locus_tag="VHC05_000744"
     CDS             4791..4982
                     /locus_tag="VHC05_000744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402070.1"
                     /translation="MQRDTSERGHQAHFVMQSHQQRRRQHQLCLEPFQKNCEFLYYEV
                     EKVKLDSEDCLTINPLGMV"
     gene            5031..5450
                     /locus_tag="VHC05_000745"
     CDS             5031..5450
                     /locus_tag="VHC05_000745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione S-transferase family protein"
                     /protein_id="HEQ5402071.1"
                     /translation="MPFIAKQTLKSQLIPQDNLLAESRFNEIMDFLTGDFPLVFRPMF
                     NPHRYTISQDNQALEKVKQASYKRMDIAMTHLDGLIGESGHVYRDQQTIADAYAYAMA
                     LWSQKTPKSYENYPHLAAFMAKMVEDSAVQQVLNAAH"
     gene            5687..6595
                     /locus_tag="VHC05_000746"
     CDS             5687..6595
                     /locus_tag="VHC05_000746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TDT family transporter"
                     /protein_id="HEQ5402072.1"
                     /translation="MKHLKNPPLVMSGLALGTLSFGNLLATYVSIFSYLGILAALFIY
                     GILLVGMVRNLNDTKMQLRQPLIASVFPTFFMTGMLLSSLFLKVTGGCWLGFLTWWLF
                     FLGNLVLIAYYQYRFVFSFSWDNVFPSWSVLFVGIAMAALTAPASRQFLLGQVIFWVC
                     LLLTAVILPFMAKKTYGIGLGQAVMPNISTFCAPLSLLSASYLATFPRPQVGMVIFLL
                     ISSQLLYAFVVVQLPRLLNRPFNPGFSAFTFPFVISATSLKMTLSFLGWQGLGWQVLL
                     LGEVLLATALVTYVYGAYLRFLFQNK"
     gene            complement(6713..6889)
                     /locus_tag="VHC05_000747"
     CDS             complement(6713..6889)
                     /locus_tag="VHC05_000747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3042 family protein"
                     /protein_id="HEQ5402073.1"
                     /translation="MIKKYQFVKGLATGVLATAATVAGAVFAVKKTIIDPEEEKAAFI
                     EENRKKAARRRVAR"
     gene            7023..7922
                     /gene="miaA"
                     /locus_tag="VHC05_000748"
     CDS             7023..7922
                     /gene="miaA"
                     /locus_tag="VHC05_000748"
                     /EC_number="2.5.1.75"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="HEQ5402074.1"
                     /translation="MTKIKIVVIVGPTAVGKTALGISLAKAFNGEIISGDSQQVYRQL
                     DVGTAKATQEEQAAAVHHLIDIREVTESYSAYEFVQDAQKAISDIVSRGKLPIIVGGT
                     GLYLQSLLEGYHLGGQVDQEAVKAYRQELDQLSDQEVYELLQVKSITIKQLNRRRAIR
                     ALELSQFADDLENAETAYEPLIIGLNDDRQVIYDRINQRVDRMLENGLLEEAKWLYEH
                     YPTVQASRGIGYKELFPYFVGEMTLAEASDQLKQNTRRFAKRQLTWFRNRMAVGFTAI
                     TAPDYPQVVHDRVRDFLGQKEKS"
     gene            7995..9233
                     /gene="hflX"
                     /locus_tag="VHC05_000749"
     CDS             7995..9233
                     /gene="hflX"
                     /locus_tag="VHC05_000749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HEQ5402075.1"
                     /translation="MIETKRQQERVILLGVELQTTEHFDMSMTELANLAKTAGVKVMA
                     SFSQKRERYDSKTFIGSGKLDEIKAIVEADEIDAVIVNNRLTARQNANLEAVLEVKVI
                     DRMQLILDIFAMRARSHEGKLQVHLAQLKYMLPRLVGQGIMLSRQAGGIGSRGPGESQ
                     LELNRRSIRHQIADIERQLTQVEKNRQTIRDRRVGSDTFKIGLIGYTNAGKSTIMNLL
                     TDDSHYEANELFATLDATTKQLYLENQFQATLTDTVGFIQDLPTELVAAFKSTLEESK
                     YVDLLLHVIDASDPNHSEQEKVVLNLLKELDMLNIPRLAIYNKVDIAEQFTATAFPNI
                     RISARSKDSKILLRRLIIDQIRDQFVPFRIKVHQDKAYKLYDLNRVALLDHYTFDQEI
                     EDISGYISPKQQWRLDDFYE"
     gene            9226..9861
                     /locus_tag="VHC05_000750"
     CDS             9226..9861
                     /locus_tag="VHC05_000750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003043928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine beta-lyase"
                     /protein_id="HEQ5402076.1"
                     /translation="MNNYIDLAKTYGGFTSLDTNYLNHLLASLTDQQKLAFITPPPSV
                     INAYFAEIYQKQSPQAATDYYFNLSKALGLFTDQPSFEEEKPFVRLNLSGKAYGFAYQ
                     NDQEVALVFSEKAEPKKPELFFELTQIFPQYMVYEDKGQLKMQAKQFEQGECEDITPD
                     DTLLSKIYRLANGITMLKGFNVEELWALSQTFSGQKYYDFAQREFMIYITQ"
     gene            9876..10805
                     /locus_tag="VHC05_000751"
     CDS             9876..10805
                     /locus_tag="VHC05_000751"
                     /EC_number="3.1.26.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Z"
                     /protein_id="HEQ5402077.1"
                     /translation="MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQR
                     QILETTIKPRKIRKIFITHLHGDHIFGLPGFLSSRSFQASEEQTDLDIYGPIGIKTYV
                     LTSLKVSGARVPYQIHFHEFDDKSLGKIMETDKFVVYAERLAHTIFCMGYRVVQKDLE
                     GTLDAEALKAAGVPFGPLFGKIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTR
                     KTSASVKLAKDADVLVHESTYGKGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVS
                     ARFLGRDCRQMEKDAATIFENVKMVQDLEEVII"
     gene            10805..11569
                     /locus_tag="VHC05_000752"
     CDS             10805..11569
                     /locus_tag="VHC05_000752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061843.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HEQ5402078.1"
                     /translation="MAQRIIVITGASGGLAQAIVKQLPKEDSLILLGRNKERLEHCYQ
                     HIDNKECLELDITNPVAIEKMVAQIYQRYGRIDVLINNAGYGAFKGFEEFSAQEIADM
                     FQVNTLASIHFACLIGQKMAEQGQGHLINIVSMAGLIASAKSSIYSATKFALIGFSNA
                     LRLELADKGVYVTTVNPGPIATKFFDQADPSGHYLESVGKFTLQPNQVAKRLVSIIGK
                     NKRELNLPFSLAVTHQFYTLFPKLSDYLARKVFNYK"
     gene            11566..13776
                     /gene="recJ"
                     /locus_tag="VHC05_000753"
     CDS             11566..13776
                     /gene="recJ"
                     /locus_tag="VHC05_000753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="HEQ5402079.1"
                     /translation="MIKSKYSWKIKDKKPDDGFFKLAKTKGLTQTAAQLIYERGIRTE
                     EALDEFLTADLSQLHDPYLLHDMAKAVPRIRQAIEEGERILIYGDYDADGMTSASIVK
                     ETLDMMGAEPLVYLPNRFTDGYGPNQSVYKYFIEQEAVSLIITVDNGVAGHEAIRYAQ
                     EQEVDVIVTDHHSLPEELPEAFAIIHPEHPDADYPFKHLAGCGVAFKLATALLESLPT
                     DCLDLVAIGTIADMVSLTGENRVLVKNGLAMLKHTERVGLQELMSLSPIDLEHFNEDA
                     IGFQIAPQLNALGRLDDPNPAIELLTGFDDQEAQAIALMIKKKNEERKALVQDIFDQA
                     MAMVDPQKPVQVLAQAGWHPGVLGIVAGRIMETIGQTVVVLTIDNGFAKGSARSLEAI
                     NIFEALNGKRELFTAFGGHAGAAGMTLPVDNLEALSDFLCQFVIERGLDQTAKNTLTI
                     DERLSLDDLSLDILKSLDKLAPYGMDHQKPVFYVKDIRVSQVRTIGQDQSHLKFKVSQ
                     GKASFDVLAFGQGSQLQEFRQATGLELAVTLSVNHWNGNTSLQFMLVDARVDGVQLLD
                     LRTKTAKVPEGIPTIEEDPNARVILINDIPEDFKTWRNQFVHKDFDAIYFKNQMKYPY
                     YLTGFGSREQFAKLYKTIYQFPEFDLRHKLTELSHYLNIEKLLLIKLIQIFEELSFVT
                     IDDGLMTVNPQAQKREISESHIYQDLKELVKFQEIMALASPKEMYDYLVKSNDQ"
     gene            13927..14445
                     /locus_tag="VHC05_000754"
     CDS             13927..14445
                     /locus_tag="VHC05_000754"
                     /EC_number="2.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="HEQ5402080.1"
                     /translation="MDLTNYIASIKDYPKAGITFRDISPLMADGKAYSYAIREIAQYA
                     CDKDIDMVVGPEARGFIIGCPVAVELGIGFAPVRKPGKLPRDVVSADYEKEYGLDTLT
                     MHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGIVAGCAFLIELEGLNGRHAIR
                     NYDYKVLMQFPG"
     gene            14526..15209
                     /locus_tag="VHC05_000755"
     CDS             14526..15209
                     /locus_tag="VHC05_000755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain-containing protein"
                     /protein_id="HEQ5402081.1"
                     /translation="MSFLEHYKSGNLVIPSALLFHYKDLFKSSDDFLVWQFFYLQNTT
                     KRDDLAPSQIAHALGKSVADINKIISSLTSQGLLDMRTIELTGEIEIIFDASPVLAKL
                     DQLFVSQTATEIDKQETPNHFKRLVDEFERELGRFLSPFELEDLEKTLRDDKTDPDLI
                     REALKEAVFNGKTNWKYIQAILRNWRKEGIVNLRQVEERRRVREGEDLSQVTISDDFL
                     SAMNLWSDS"
     gene            15206..15862
                     /gene="nth"
                     /locus_tag="VHC05_000756"
     CDS             15206..15862
                     /gene="nth"
                     /locus_tag="VHC05_000756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease III"
                     /protein_id="HEQ5402082.1"
                     /translation="MRIGKARLAKVLTIIGQMFPEAKGELDWETPFQLLIAVILSAQT
                     TDKAVNKVTPGLWQSYPEIEDLAFAELSDVENALRTIGLYKNKAKNIIKTAQAIRDDF
                     KGQVPKTHKELESLPGVGRKTANVVLAEVYGVPAIAVDTHVARVSKRLNISSPDADVK
                     QIEADLMAKIPKKDWIITHHRLIFFGRYHCLAKKPKCEICPVQSYCKYYQNTYGKSKA
                     "
     gene            15934..16620
                     /locus_tag="VHC05_000757"
     CDS             15934..16620
                     /locus_tag="VHC05_000757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenine-N(1))-methyltransferase"
                     /protein_id="HEQ5402083.1"
                     /translation="MDSQLSNRLAQVAAYVPKGVKLLDVGSDHAYLPIFLVETNQISA
                     AIAGEVVRGPYESALKNVTQSGLAEHIQVRLANGLAAFEEADDVTAITICGMGGRLIA
                     DILEAGKEKLQGIERLVLQPNNREDDLRAWLSVNAFKIVAETIMAENDKYYEIIVAEH
                     GEKALSATELRFGPYLSQEKSVVFKEKWQREMDKLAYALSCIPEEKTQERQLLLTKIQ
                     QIKEVIVHES"
     gene            16610..17398
                     /locus_tag="VHC05_000758"
     CDS             16610..17398
                     /locus_tag="VHC05_000758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019781659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HEQ5402084.1"
                     /translation="MKAKTLIDAYEAFCPLDLSMEGDVKGLQMGSLDKDIRKVMITLD
                     IRESTVAEAIKNEVDFIITKHAPIFKPLKDLVSSPQRDILLDLVKHDISVYVSHTNID
                     IVPGGLNDWFCDLLEIKEATYLSETKEGFGIGRIGTVKEQALEELASKVKRVFDLDTV
                     RLIRYDKENPLISKIAICGGSGGEFYQDAVQKGADVYITGDIYYHTAQEMLTEGLFAV
                     DPGHHIEVLFTEKLKEKLQGWKEENGWDVSIISSKASTNPFSHL"
     gene            17438..18544
                     /locus_tag="VHC05_000759"
     CDS             17438..18544
                     /locus_tag="VHC05_000759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HEQ5402085.1"
                     /translation="MKIAIIGAGIVGSTAAYYLQQSGQKEVTIFDHGQGQATKAAAGI
                     ISPWFSKRRNKVWYRMARLGADFYQQLVSDLQTDGFATDFYQQNGIYLLKKQEEKLKD
                     LYQLALSRQEESPLIGHLEVKKREEIQEAFPGLVGFDNCLYASGAARVEGAALCETLL
                     KASGYPVIRQKVTLKQQGSGYEIAGHYFDQVILAAGAWLPDLLMPLGYQVDVRPQKGQ
                     LLDYDVHHIISDTYPVVMPEGEIDLIPFNQGKISVGASHENDKGYDLEPDWQVLEKLE
                     MQALTYLPLLKEATQKSCRVGIRAYTSDYSPFYGQVPGLKNLYTASGLGSSGLTVGPL
                     IGYELAQLLLGHEGLLTPSDYSPEPYLLRSTGKA"
     gene            18602..19471
                     /gene="rfbA"
                     /locus_tag="VHC05_000760"
     CDS             18602..19471
                     /gene="rfbA"
                     /locus_tag="VHC05_000760"
                     /EC_number="2.7.7.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000676146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="HEQ5402086.1"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLA
                     GIKDILIISTPQDLPRFEELLGDGSEFGISLSYKEQPSPDGLAQAFIIGEEFIGDDRV
                     ALILGDNIYHGNGLTKMLQKAAAKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEK
                     PEVPKSHFAVTGLYFYDNDVVEIAKNIKPSARGELEITDVNKAYLERGDLSVELMGRG
                     FAWLDTGTHESLLEAAQYIETVQRLQNAQVANLEEIAYRMGYISKEDVHKLAQSLKKN
                     EYGQYLLRLIGEA"
     gene            19471..20064
                     /locus_tag="VHC05_000761"
     CDS             19471..20064
                     /locus_tag="VHC05_000761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase"
                     /protein_id="HEQ5402087.1"
                     /translation="MTETFFDKPLACREIKEIPGLLEFDIPVRGDNRGWFKENFQKEK
                     MLPIGFPERFFEEGKLQNNVSFSRQHVLRGLHAEPWDKYISVADDGKVLGAWVDLREG
                     ETFGNVYQTVIDASKGMFVPRGVANGFQVLSETVSYSYLVNDYWALDLKPKYAFVNYA
                     DPSLGITWENLAAAEVSEADKNHPLLSDVKPLKPKDL"
     gene            20308..21348
                     /gene="rfbB"
                     /locus_tag="VHC05_000762"
     CDS             20308..21348
                     /gene="rfbB"
                     /locus_tag="VHC05_000762"
                     /EC_number="4.2.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000277597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="HEQ5402088.1"
                     /translation="MYKNIIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNRA
                     NIEAILGDRVELVVGDIADAELVDKLAAKADAIVHYAAESHNDNSLEDPSPFIHTNFI
                     GTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGQGEGPGEKFTAETKYNPSSPYS
                     STKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILAGIKPKLYGE
                     GKNVRDWIHTNDHSTGVWAILTKGRIGETYLIGADGEKNNKEVLELILEKMGQPKDAY
                     DHVTDRAGHDLRYAIDSTKLREELGWEPQFTNFSEGLEETIKWYTENETWWKAEKDAV
                     EAKYAKTQEVIK"
     gene            complement(21431..22384)
                     /locus_tag="VHC05_000763"
                     /pseudo
     CDS             complement(21431..22384)
                     /locus_tag="VHC05_000763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990094.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
     gene            22513..22833
                     /locus_tag="VHC05_000764"
     CDS             22513..22833
                     /locus_tag="VHC05_000764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VRR-NUC domain-containing protein"
                     /protein_id="HEQ5402089.1"
                     /translation="MTTESLIQNQIRVALSKAGHMVFRANVGKVKTVDGRLFDTGLPK
                     GFCDLFGFKPDGQIFFIEVKNETGRVRPEQKKFMEVMASRGALVGVARSVEDALKIVN
                     DTSR"
     gene            22817..23173
                     /locus_tag="VHC05_000765"
     CDS             22817..23173
                     /locus_tag="VHC05_000765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402090.1"
                     /translation="MTLVDDFYKQMEPSIKAFLDDNITIADKEEADRVYRSVKYYKKL
                     NRLPPPDVLEWFQRIYTTEEMIMLIKQSYRLKQKKTDEDDKIYEKWMFKNYGDVKLVK
                     KIKRINALAKAREMGL"
     gene            23430..23639
                     /locus_tag="VHC05_000766"
                     /pseudo
     CDS             23430..23639
                     /locus_tag="VHC05_000766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054804.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4355 domain-containing protein"
     gene            23658..24548
                     /locus_tag="VHC05_000767"
     CDS             23658..24548
                     /locus_tag="VHC05_000767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage capsid protein"
                     /protein_id="HEQ5402091.1"
                     /translation="MVTSRTYPEENLIKSTDLKYPITIDVTNKFQENISKLLEMLGVT
                     RKISVSVGMTLKTYAGYDVTLAEGNVPEGEVIPLSKVERKIHSEKKIELKKYRKATTG
                     EDIQMYGSNEAVTNTDNALVRQLQKKIRTDFVTALKTGTGTQDALGAGLQGALASAWG
                     KLQVLFEDYGSERAIVFANSLDVAEYIAKAGITTQTAFGLTYLVDFTGTVIISTNDVT
                     KGEIWATVPENIIFAYINPNNSELAKEFNLYGDPTGYIGMNHFQENTTLTIQTLLVSG
                     MLMYPERIDGIVKVTLTPGV"
     gene            24560..24853
                     /locus_tag="VHC05_000768"
     CDS             24560..24853
                     /locus_tag="VHC05_000768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rho termination factor N-terminal
                     domain-containing protein"
                     /protein_id="HEQ5402092.1"
                     /translation="MAYTVKARFFDLLDNSFLYEVGDSFPRKGYEPSKERLESLLSSN
                     NTEHKPFIEVSGNGNSLDGLKVDELKAKAAELGIELPSNAKKAEIIELLQAHI"
     gene            24867..25211
                     /locus_tag="VHC05_000769"
     CDS             24867..25211
                     /locus_tag="VHC05_000769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402093.1"
                     /translation="MDETKQAIIDRVRVRLADETSLKEELLEELTQTAIDRINLKVGD
                     VVFNPLFNSITVDVVVKMYRRMYFEGIDTEKADTISTKFIENVLAEYGEELASYKKDR
                     LAVLNKKVVRFL"
     gene            25208..25519
                     /locus_tag="VHC05_000770"
     CDS             25208..25519
                     /locus_tag="VHC05_000770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402094.1"
                     /translation="MRFVNFDLVTPQKTGKKDKLGNDITKDVVKRDAKGRFTEWSADD
                     VSLYGRDLTSSARKLLTNQVSKAEAKQASHVVIDGSKYKVESVKDLGRWRLLVIKGYR
                     L"
     gene            25516..25911
                     /locus_tag="VHC05_000771"
     CDS             25516..25911
                     /locus_tag="VHC05_000771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880257.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402095.1"
                     /translation="MRMSMTGMPALEVKLRSMSDKRWDRVVNKNLTEMFNRSARPPGT
                     PIGKNTKRHKSGELLRSRRLKKVNSSKGVITGNFGYIKDYAPHVEYGHRLVRNGKQIG
                     YVNGTKYLFNNVKKQREIYRQDMLNELRK"
     gene            25913..26323
                     /locus_tag="VHC05_000772"
     CDS             25913..26323
                     /locus_tag="VHC05_000772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5072 family protein"
                     /protein_id="HEQ5402096.1"
                     /translation="MLKKLGLVDLHASIKQKIEDKTGLMAYDHVPEDMPSPFYFIEVV
                     DKRPEDTKVMWCEVFTVWIHAIAEAGKSKIAIYDMIEKLEEALTEELVLPEEIDILRQ
                     SEVGMQSLQEDETGEMHAIVAYEIKVSYGFKVKI"
     gene            26335..26592
                     /locus_tag="VHC05_000773"
     CDS             26335..26592
                     /locus_tag="VHC05_000773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage major tail protein, TP901-1 family"
                     /protein_id="HEQ5402097.1"
                     /translation="MVAFDQNVYCNFDASATKAIVCIKVINGKTKKGMFGGLASVSDY
                     SLEAPYDDGMTYSISLEGNGALIDLSTLSSEDAGKVTAMPS"
     gene            26605..26895
                     /locus_tag="VHC05_000774"
     CDS             26605..26895
                     /locus_tag="VHC05_000774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402098.1"
                     /translation="MDKELIIIDEKQYELKYNEKTIETVEALTGKAFMDVIVNNKGML
                     SLSMLRQYFSNALYAVEGGRVSSEQGSNVFTKVLNTKGYVYLASGRWYNSSC"
     gene            27245..28429
                     /locus_tag="VHC05_000775"
     CDS             27245..28429
                     /locus_tag="VHC05_000775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016355963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402099.1"
                     /translation="MQRLLDEAGKLSGMEFDINNFSDIIQAIHIIQDNLGVTGTTARE
                     ASETISGSFSQAKASVIDFMGSLGGDGSDVDAKMQAMIQSITVFADNVKEALGRIWDN
                     LPLQEYQKNLLLIAVVGGPILVVVGTIFGAIANIMTVVSGILTVLGMMTPIGWIIVAA
                     IAAIVAAVVFWDDIVAEVGQKFELVKIIGMAMWESFKDGVSSFGKLIQNVVGKIGGWF
                     AEAWNTASDTATRIFTRVGETISGIFSGVVSGIKSLINGAIGGINKVIGITNKLPGVN
                     IPKIPYLARGTSDWQGGLARINEGGRGELVHMPNGTTVVPHDVSMKYARESAKANSGI
                     AYVDSNDEIAKSALKLANDAIKRPVVLNINGREVARTTGGDMRDYLNSRDMTLKRLRG
                     EV"
     gene            28430..29914
                     /locus_tag="VHC05_000776"
     CDS             28430..29914
                     /locus_tag="VHC05_000776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail family protein"
                     /protein_id="HEQ5402100.1"
                     /translation="MTTMTFNDVDLSSLITIMSVNRDIGNERQAETNDAPFVGLHVKK
                     IKTSAKIITVDFYLKDRTNEYALNQLKHKLAGIFNVNEQVKVTFSDEPDKYYLAIPIN
                     KISASDPIAWLSLVSLELLVPDGVAHSVSYKKITNYRQDGKKLLIDITNNGNVDAHPI
                     ITVKHNAENGYLAFVNKSSVFEVGDREIADAEIREKSVVAYDFKDERIVNALTAGKKN
                     VAILNDSTQVLDKNLLLNTVWGRKHLELEGSVAPSGNHAGTLTFDIPDGGSLYDYLWW
                     RQIFWVGTVSQLGFIKIMVSDENGHFLYGVETIKRTLGTKTEYNFLVTNGKGGYKITD
                     LRWTFDATHFETQNPFNEPRGWSDMTRADDTVSVFWWGSQNKRVFPELKGKKSKQVHI
                     AIGTIQGSPLVTHMYIDGFYYRKDKVPYEFNIPNAFGAGTEVVINAENDTVLVDNIPK
                     ANIIADGFFSFPKIPPGTSTLEVYSSSWSTANPDITLNFEERWL"
     gene            29915..33364
                     /locus_tag="VHC05_000777"
     CDS             29915..33364
                     /locus_tag="VHC05_000777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEQ5402101.1"
                     /translation="MLITIHNANLEKVAYIDNDKQDTLNYYDDKFSQYLNTANSTFEF
                     TVYKRGIKSDTIKEKAYLTLTERSFVSIKYNGKSYLFNVMTTDETDIEIRCYCENLNL
                     ELLNEYAGPYRAATQMSFVDYCNLFGILKNGAITIGTNETTDQKRTIEWTGQDTNLKR
                     LLSIANNFDAEIEFVTHLKNDSSLKSFVMNVYKKNDATNQGVGRRRDDIILQYGKNIE
                     SVRRKIDKTGIYNAIRPSGKITTTTTTTTAKQGSVQTGSVLWSGGNLTYAGHVMQSSV
                     VNTILSLCSKYKLLPSGVFSQLYLESFWGDTPVGRADNNWGGITWTGATTRPSGINVS
                     QGQPRAEGGHYNHYASVDDYLKDYTYLLAEQGIYAVKGKLTIDEYTRGLFRVGGATYD
                     YAAAGYDHYAPLMRDIRAGINRNNNGAMDNVDNQFKNGGSTSQNTTQIAAKTKAVLAE
                     ATGLKGQRVGSGQCYALAAWYAMKLDGPGLNGGVTSFRGLIGAGAAAAQIGTDYNWGQ
                     FGWKVVQPNKVADLITGSIVNIRANAGSPVFTGAWGHTVVVKSLSGDTLTVLEQNYNN
                     VQTVQEHTYSASAYLSVVQTVCYPPEIVKGRRVEGTAQAEQPQPETTTTSEEKEVLIN
                     PSLYREWKNESGQVEFYVKNSMLYAPLSKSLYPSAFTGIETDDNWIRKDLDVDTESEE
                     KLISVALADLRKHCYPAVTYEVSGFIGDLDIGDTIKINDPEYTPSLILEARVSEQHIS
                     FTEPNQNKTVFDNYRALESKVSQGLIDRMNELAEAAKPYDLRLMTDNGNVFLNGEGRT
                     ILTAELWKGNKKFDASYQFKRDGQLVGAGLQLAVDAKDVPADKPLIITVEAYLNNELI
                     ASKQITFTNSLGEQGPAGRGIVSTEDYYLASPNRTGVTSATSGWTKTPQEITETNKYH
                     WYYHVDVYSDGTRKETTPAIIGVYGDKGSDGKQGEKGNDGPMGPQGPAGALDEKQLQD
                     INNKIDGKADQNLTIEQINKLAELQSIANAELQAKASIDALASLQKQVQSAIAAMNAS
                     QKLSEQDLITASQRAIKATNDILDLKEQWNFIDNYMSASEEGLIIGSKDGTSSVRVAK
                     DRIAFYSAGAEVASITGGMLKIDNGMFVATLQVGHFREEMYKVDGVDKHINVTRYYET
                     IVG"
     gene            33369..35231
                     /locus_tag="VHC05_000778"
     CDS             33369..35231
                     /locus_tag="VHC05_000778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402102.1"
                     /translation="MAEFWSNNDRGYRIKLTIDQVSQNTLANSSQVRVKLDLLNTTTT
                     FTQYSCSAYVDLNGQRIDWSDSPSVLRYNSTISLIDRTITVNHNADGTKSFGFIASFS
                     GSGGWSPGTLTVGSGTFTLTTIPRSSSVVVSSGTIGSAITININRQSSSFKHNLRYQW
                     GNKTGTIASDVDTSAVWTIPLDFASDIPNSTSGSGTIYVDTYNDSTLTGTQQVPFTVT
                     VPDSMKPTLSSISLSDAHTVAGNVVSSADYFIQVYSDIRVNFESASGSYGSTIKGYYA
                     EIVGKGQSTEQNGGTLGNMLYDGQITIRAKVIDSRGRESQPVDKTVTVLKYFPPALSF
                     DVARSGYGSDTLTVTRRASIAPLSVFGTQKNTMTLSFSVAELGSSYFSANNGSASGAW
                     ANVSSLVNSSANLYGAFSPTKSYTVKGILSDKFSRTEFTFDVGTESVVMSIAKNGIGF
                     QKIWEKGAIDAKGDAYISGKLFVNNTEVKPSFDKTEILNMVYPVGAIYMSTSSANPST
                     FIGGTWQRYAQGRTIVGVSENETEFNYVGKTGGAKTHTLTNEEMPSHSHGDKTISSGG
                     RPISSNAGWDNTNVGLYKSTDYNQINAFNKSSGGDQPHNNLQPYITTYIWLRTA"
     gene            35242..35589
                     /locus_tag="VHC05_000779"
     CDS             35242..35589
                     /locus_tag="VHC05_000779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1366 domain-containing protein"
                     /protein_id="HEQ5402103.1"
                     /translation="MLVITSNYPEQMPDGSVSGAKVMLDGIDDHAGWHIPLTLPKEYL
                     DKPQSEVMTLCEKMIYQQLKPQKALNEKFAKLDATIEKGENMLKFATGILNQIIAAKE
                     EETTDDETVEKMD"
     gene            35739..36062
                     /locus_tag="VHC05_000780"
     CDS             35739..36062
                     /locus_tag="VHC05_000780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767362.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402104.1"
                     /translation="MTIDVTLFAQWCVALTAIIVFLKWVSAPVKHVLDNNKKAMEALE
                     SAIVKISDDLKDNNFKWTESKNHRDRLQKVQDQHEIRIGIVEDRLISHDEQLKTLWKV
                     KEEKK"
     gene            36062..36394
                     /locus_tag="VHC05_000781"
     CDS             36062..36394
                     /locus_tag="VHC05_000781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin"
                     /protein_id="HEQ5402105.1"
                     /translation="MEELIQVITGSALSILTIFAGIVVKLIKDYLLKKGGEKAVKIAE
                     IVARNAVEAVEQIAYDKDIKGIEKLTEAKIAVRDELSKHNVYLSDKQMEVFIEAAVKR
                     MNDSWKGQ"
     gene            36396..37160
                     /locus_tag="VHC05_000782"
     CDS             36396..37160
                     /locus_tag="VHC05_000782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEQ5402106.1"
                     /translation="MATVSEVISYWRGLADTNQGYDADLAWGWQCADVTNGTTTNFFG
                     VTLWGNAIDLLDSAKAQGLEVIYDAPGINPKAGDLFVMYTYAHPYGHTGIVIADSDGY
                     TIQTIEQNVDGYSDNNGDGINDQFQVGGPARYVTRAFSDGDGYIVGWIRPPYSDTSSE
                     KQSQSQAPSGFRKLKDEVGTFEVMVPALNVRREPSLNGEIVACYQYGMTGTYDSVYVG
                     DGYIWVSYVGASGMRNYMAVGDADGDYNVNPYCKFY"
     gene            37172..37774
                     /locus_tag="VHC05_000783"
     CDS             37172..37774
                     /locus_tag="VHC05_000783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402107.1"
                     /translation="MGYNSTNLKQVDGGDVIKQGDTSSLFSFNLLDENNNVIDLNGKQ
                     ATIYFTRNRKTYLTKTTDVIDNKVDFTINKILEIGTYYIEVHCDGYVFPSDDSVTLDV
                     RRSGQKYVVSTDLITDTTIQKLSADIEYLKSKVTQNQHLFEQVSPQTEWTITHNLIKY
                     PSVTIVDSAGNEVFGSVEYISTTKIIVRFSAPFAGKAILN"
     gene            37785..38558
                     /locus_tag="VHC05_000784"
     CDS             37785..38558
                     /locus_tag="VHC05_000784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402108.1"
                     /translation="MSTFLTNINLNKNELQNAVVQNLGSEPQDPKTGQFYYDSVANKL
                     KIYNGTSWVALDKETAESIVNLINSGESKIDKSKVDGLEEAINRASMTGQAIATALNE
                     DTGGVTVNQDKITGLTDKLAEIATNKASATRESQDALQEAKVYADQKVAGLVDSASED
                     YNTFKELETFIKQNAKGLAAISNVAKKFSKTFGDARAKEFTITHNLKTRDVNVTIRET
                     NFPYAIVYADIKVTDENSILIATGAEVPTQNQYTVTITG"
     gene            38568..38789
                     /locus_tag="VHC05_000785"
     CDS             38568..38789
                     /locus_tag="VHC05_000785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003055886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402109.1"
                     /translation="MRYIGESQLSKDLVTKDYVDNKVTNLASKDDIVNLGKIKDSQTG
                     AFLEVKIVPNGQVPYDTTGMIVFERSGGK"
     gene            38789..39448
                     /locus_tag="VHC05_000786"
     CDS             38789..39448
                     /locus_tag="VHC05_000786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402110.1"
                     /translation="MSVQEIPDEIFYRLIEQTVDTKLVWDKDTQIGSYYISIHDKYSF
                     ESGRDVNIYKILSSTQADVYKANKYNYQSSSKPDTSVPQPKPPEQPPLKNKSLYQSIT
                     IDGLPIARVICNNHVIWSQSVEQQEVYNITAYVDASVSKLNDSAIIDYNRDFAAYGVN
                     WSRVDRVAVEVDDKIVAKLQAPVYDFGVRGGTTMSVEKWDYPSNTIEKYKNPTFKISQ
                     H"
BASE COUNT        12479 a         7058 c         8647 g        11294 t
ORIGIN      
        1 ctggtttcac agatcataag gaagtcttcg cttattctgc tcaggtggct tgtgacaagt
       61 atggatgggc gcttgcttat agtgttgagg ctggcaatat ccatgatagt caggcttttc
      121 ctgcactttt tgccaagctt gaacccttga aaccacagtt tattattgcg gattccggct
      181 ataacattcc cagcattgcc aagtttctga ttgataagga gatcactcct gtccttcctt
      241 acacacgacc aagaggaaag aaagaccttc tacgtccgaa agaattgatt tatgatgagc
      301 actttgattg tgtcatttgc cctgaacatc aagccttgac ctaccgcact acgaccagag
      361 aaggctaccg agaatacaaa agtgaccctg caatttgtgc caattgtccc ctgttatctg
      421 tatgtacgac cagtaagaac caccaaaaag ttgtcacacg gcatatttgg aaagactatt
      481 tggaacagtg cgaggacatt cgtcatcaaa gggggatgaa ggagctctac cagcatcgga
      541 aagagacgat tgaacgacta tttggcacag ccaaggaata ccacaatctc cgctatacga
      601 gagagaaagg caagtccaaa atggaagata aggttggact gactttggca tgcttaaatc
      661 tcaaaaaact ggtcaaaagg atggcgggag agccttttta ttttgttcag atgaggtggt
      721 ttaagcacgg aaacagccat ttttatctaa aaacactaaa aaagacaagc accaaatcga
      781 tgtttgtctt caatctgaga gcttgctctt gcaagctttt ttgattttgt gtaaaataga
      841 caaagtgagg taaagtgatg agtaaaaaag ataaaaaaat tgaaatccaa ctgattgatc
      901 acaaagttat ggttaatgag actaggattg atggctatca attacaaatt ggtaaacgtg
      961 tggttggaga aattgcagag cttgatgaga aatttgcggt aataaaaaat gacactgtgg
     1021 atagcttctt taaaaccctt gagcaagcgg ttgaaaatat cattgaaaac tacaatttga
     1081 atcattaaaa gtaggtaaaa acacttgcca gcttacaaaa actatgatag aatagttttt
     1141 gttgttacgg aaagatagcg aagaggctaa acgcggcgga ctgtaaatcc gctccttcgg
     1201 gttcgggggt tcgaatccct ctctttccat ctcagaaaga tgatttatta aaagattaga
     1261 tttctgtgaa agacattttg gggtatagcc aagcggtaag gcaagggact ttgactccct
     1321 catgcgttgg ttcgaatcca gctaccccag tcagaggtat cagatgttgt ctgagaccgt
     1381 caaagataag agttgttgtc gttgcgggtt accttgagaa aatatattgt tatcaaaagc
     1441 tagcattggc tagcttttgt tggaggattt tttagaatga atgaatttga agatttgcta
     1501 aacagtgtta gcgaagtgaa ccctggtgat gttgtcactg cggaagtttt aactgttgat
     1561 aacggtcaag caaacgttgt tatcgaagga acaggtgttg aaggtgtctt gacacttcgt
     1621 gaattgacta acgaccgcga tgctgatatt aacgactttg ttaaagctgg cgacacagtt
     1681 gaagtacttg ttcttcgtca agtagtaggt aaagatactg atacagttac tttcctagta
     1741 tctaaaaaac gtttggaagc tcgtaaagcc tgggacaaac ttgttggtcg tgaaggcgaa
     1801 gttgttactg ttaaaggtac ccgtgctgtt aaaggtggcc tttcagttga atttgaagga
     1861 cttcgtggat ttatccctgc ttcaatgatt gacactcgtt ttgttcgcaa cactgaaaaa
     1921 tttgttggac aagagtttga tgctaaaatc aaagaagttg atgcagcaga aaaccgtttc
     1981 atcctatcac gtcgtgaagt tatcgaagag gccgctaaag aagctcgtgc tgaagtgttc
     2041 tctaagattt cagaaggtgc agtcgttaca ggtactgtag cgcgtttaac aagttttggt
     2101 gctttcattg accttggtgg tgttgacgga cttgttcacg tgactgaatt gtctcacgaa
     2161 cgtaacgtgt cacctaaatc agttgtttca gttggtgaag aagttgaagt taaagttctt
     2221 tcaattgacg aagaagctgg tcgtgtgtca ctttcactta aagcaacaac acctggacca
     2281 tgggacggcg ttgaacaaaa acttgctcaa ggtgatgttg ttgaaggtaa agtaaaacgc
     2341 ttgactgact tcggtgcttt tgttgaagta ttaccaggta ttgatggact tgttcatatt
     2401 tcacaaattt cacacaaacg tgttgaaaat ccaaaagatg tactttctgt aggacaagaa
     2461 gtaacagtta aagttcttga agtgaatgca gctgatgagc gcgtatcatt atcaatcaaa
     2521 gctcttgaag aacgcccagc gcaagctgaa ggagacaaca aagaagaaaa acgtcaatca
     2581 cgcccacgtc gtccaaaacg tgaatcaaga cgtgactacg aactcccaga aacacaaact
     2641 ggattctcaa tggctgatct tttcggtgat attgaattgt aataaatcta aaaagttgag
     2701 gttttcctca actttttatt gtcttctggt tagaaaagtt atttcatatt atttcatttt
     2761 atgatatact ataagggtat tgacaaagtt gtgaccacct ttagtgtaat ggatatcacg
     2821 taagattccg gttcttgaga tgggggttcg attccctcaa ggtggataga aatcatataa
     2881 aaaagcctta tttgataggc tttttttgtt tcttttccaa aatttgtcca aaattatcta
     2941 gaagagttga cgaatctttt caaaatcatt atttttctga ccttgaaaac gatgagtata
     3001 ggttttaaat atctctgtaa tgccacagcc tgaattttat ttgactcaga ttcataagat
     3061 tgtaagtaat caaggttaat tattgatgag atggtgaaac catttttagc aagtgctatt
     3121 aaagcatttg gtgatttttc gaaacgtttt aaaatttaag aagagtttta cctaaaaaaa
     3181 ctagctgtgt catctgtcta agaacagtta gttttttagt attaggtttt taaagaagaa
     3241 acgtctcaat cttaattgga taatccttat atttggattt taatatagta gctacttctt
     3301 gatatagtat ccgaatctgc gctctttttt caggcatgtt aaaaccaaca taatggaatt
     3361 gtgattcaat agttacaaat aaatcatgga acaggtgatt catagtttct aatttatggc
     3421 aaagcagtcg atcttcttga atgaatgttg ggggattttg atcttctccc cagtaagcat
     3481 caacacgtga caacggataa gtcccatatt ctaaacaaag ttcataagtc attttggcct
     3541 ccttgtttta tcttagcatt ttctaaataa agcttctaat gatttgctta aaggagtaat
     3601 ggattgccat ctcatctcat caaaaataaa ttgagatcta ttttgtgaaa aaaaaagaca
     3661 aacaaatggc ttgcctagac ttgtttttcc tagatataat aggaagtaac tgaataacaa
     3721 tgaaggagaa aaaatgtcag aaaaaatcag agttttactc tattataaat atgtttcaat
     3781 tgaaaatgcg caagagtacg ctgcgaaaca tctagaattt tgtaaatcta ttgggcttaa
     3841 aggtcgtatt ttgattgcgg atgaggggat taatggaact gtttctggag attatgaaac
     3901 aactcagaag tatatggatt gggtccacag cgatgagcgt tttgctgatc tttggttcaa
     3961 gattgacgag gaaaatcaac aagctttccg taaaatgttt gttcgttata agaaagagat
     4021 cgtgcacctt gggttagaag acaataactt tgatagtgat attaatcctt tggaaacaac
     4081 aggtgagtat ttaaatccta aacaatttaa agaagccttg cttgatgaag atactgttgt
     4141 tttagatacg cgtaatgatt atgagtatga cttaggtcac ttccgtggag caattcgtcc
     4201 tgatattcgc aatttccgtg agttaccaca atgggtacgt gacaacaaag ataagtttat
     4261 ggaaaaacgt gttgttgtgt actgtacggg tggtgttcgc tgtgagaaat tctcgggttg
     4321 gatggttcga gaaggcttta aagatgttgg acaattacac ggtggtattg caacatatgg
     4381 aaaagatccg gaagttcaag gtgaactttg ggatggtgcg atgtatgttt ttgatgatcg
     4441 tatctcggtg ccaattaatc atgttaatcc aactgtcatt agtaaagatt attttgatgg
     4501 aacaccttgt gaacgttatg tcaattgtgc aaatccgttt tgtaacaaac aaatttttgc
     4561 ttcagaagaa aacgaaacga agtatgttcg agggtgctcg cctgaatgtc gtgcacatga
     4621 acgtaatcgc tatgtgcaag aaaatggttt atcacgtcaa gaatgggcag aacgtttaga
     4681 agctattgga gaatccttgc cagaatttgt aggtgcctaa tatctcaaaa caaatcagga
     4741 aactggtttg ttttttgtga tacagatgat gagaccaaat tgcaaagact ttgcaacgag
     4801 ataccagtga acgtggacac caagctcatt ttgtcatgca gagccatcaa cagcgaagac
     4861 gtcaacacca actttgtcta gaaccttttc aaaagaattg tgagtttctg tattacgagg
     4921 tagagaaggt aaaactggat tctgaagact gccttaccat caatcctttg ggaatggttt
     4981 aagctttaca gcttgatgat ggtcaaattg tcacacaggc aggtattatc ttgcccttta
     5041 tagcgaaaca aaccctgaaa tctcagctca ttccccaaga taatcttttg gcagaaagtc
     5101 gattcaacga aatcatggac ttcttaacag gtgattttcc ccttgttttt aggccaatgt
     5161 tcaaccctca tcgctacact atttctcaag acaatcaagc gcttgaaaaa gtcaaacaag
     5221 cttcttacaa gcggatggat attgctatga cgcatttaga tggtcttatt ggggagagtg
     5281 ggcatgttta tcgagatcaa caaaccattg cagatgctta tgcttacgcc atggcgctat
     5341 ggtctcaaaa aacaccaaaa tcttacgaga attatccgca tctggcagcc tttatggcaa
     5401 aaatggtgga agattcagct gttcaacaag tgcttaatgc agctcactaa atcaaaaaga
     5461 agaagtaaag atcagaccaa gtcttctcta ctctttcatt tttctagaga agagtggtca
     5521 ctccttagct ttttaagcag tttcctagtt ttgcgagaat gtaaaaaaac aatggcaaga
     5581 gccttaaatt ttctttcgcg ggtggtgtca aaaatgctcg aaatgtgata aaataaacaa
     5641 gattatgtca ctaaaaatag ctgttaatag gcagaaaagg acacttatga aacaccttaa
     5701 aaacccacca ttggtcatgt caggattggc attaggaacg ttgtcatttg gcaatttgtt
     5761 ggctacttat gtttcgattt ttagttattt gggaattctg gcagctcttt ttatttatgg
     5821 tatcttgctt gttggcatgg ttaggaacct taacgatacc aaaatgcagt tacgacaacc
     5881 tctaattgcc tctgtttttc caactttttt tatgacaggg atgttgttgt cttcactctt
     5941 tctcaaagtg acaggagggt gttggttagg ctttctcact tggtggctat tctttttggg
     6001 aaatcttgtc ctgattgctt attaccagta tcgttttgtc ttttcttttt catgggataa
     6061 cgtttttcct tcctggtccg tgctttttgt tggaattgca atggcggcat taacagcacc
     6121 tgctagtagg cagtttttat taggacaggt gattttttgg gtttgtcttc tcttaactgc
     6181 tgtgatttta ccttttatgg ccaaaaagac ttatgggatt ggtctaggtc aagcagtaat
     6241 gcccaatatt tcaacgtttt gtgcccctct gtccttactt tcagcgtctt atttagcaac
     6301 ctttcctaga ccacaagtag gaatggttat ctttcttctc atcagctcac aactgttata
     6361 tgcttttgtg gttgtacagc ttcctcgctt actcaatcgt ccctttaacc caggtttttc
     6421 agcttttacc tttccgtttg tgattagtgc cacttcctta aaaatgacct tatctttttt
     6481 aggttggcaa ggtttaggtt ggcaggttct tttgctagga gaggtattgt tggcgacagc
     6541 tttagtcaca tatgtttatg gggcttacct gagatttcta tttcaaaata agtaaagcag
     6601 ctaatatctt ggctcatcaa gagacagtta ctactaacta gttatcgaga ttactaaaaa
     6661 agaggccggc actttaatgt gctagtctct tttaaattga tccattgtca cgttagcgag
     6721 ctacacgacg acgcgcagct tttttgcggt tttcttcaat gaaagcagct ttttcttctt
     6781 cagggtcaat gattgttttt tttacagcaa agacagcacc agcaacagta gcagcagttg
     6841 ctaggacgcc agtagcaaga cctttaacaa attgatattt cttaatcatg atcattctcc
     6901 atttctagtg aaggacctca gtggtcctta atcttatgtt ataatatatg gtagcgaaaa
     6961 ataagctaat tttcaagtaa aaggcgtttt tggacacgct tttctaatag aaagacaaga
     7021 aaatgacaaa aataaaaata gttgtgattg ttggtccgac agcggttgga aaaacagcac
     7081 ttgggattag tttagccaag gcttttaatg gagaaattat ttcaggagat agccagcaag
     7141 tttatcgaca gttggatgtt ggaacagcca aggccactca agaagagcaa gcagcagcgg
     7201 ttcatcactt aattgatatt cgtgaggtga cggagtctta ttcggcctac gagtttgtcc
     7261 aagatgctca aaaagctatt tcagacattg ttagtcgtgg gaaattacca attattgtag
     7321 gtggaactgg tctttactta caaagtttac tcgaaggtta tcatctagga ggtcaagttg
     7381 accaagaggc ggtaaaagct tatcgacagg agttagacca gctgtctgat caagaggtgt
     7441 acgagctttt gcaagtaaaa agcattacta ttaagcagct taaccgcagg cgggccattc
     7501 gtgccttaga gttaagtcaa tttgcagacg acttagagaa tgccgagacg gcttatgagc
     7561 cgcttattat cggcttgaat gatgaccgcc aagtcatcta tgaccgtatc aatcagcgcg
     7621 tggatcgtat gcttgaaaac ggcttgttgg aagaagcaaa atggttatat gagcattacc
     7681 cgactgttca ggctagtcgt ggcataggtt ataaggaatt attcccctat tttgtaggtg
     7741 aaatgacttt ggcagaagct agtgatcagt taaaacaaaa cacgagacgt tttgccaagc
     7801 gacagctaac ttggttccgc aatcgaatgg ctgttggctt cactgccata acggctcctg
     7861 attacccaca ggtagtacat gatagggtca gggattttct tggtcagaaa gagaagtcat
     7921 gacgcaaaat tagcagaatc tgttgaagat atgttataat agaatttacg gaatttggag
     7981 gattggtaaa ggtgatgatt gagacaaagc gtcagcaaga aagagtgatt cttttaggag
     8041 ttgagcttca gacaacagaa cattttgata tgtccatgac agaattagct aatcttgcca
     8101 aaacagctgg cgtcaaagtt atggcaagtt tcagccaaaa acgagaacgt tacgacagca
     8161 aaacctttat cggctcaggg aaactggatg agattaaggc gattgtggaa gctgatgaga
     8221 ttgatgcagt tattgtgaac aatcggttga ctgctaggca aaatgctaat ctagaagctg
     8281 ttttagaggt aaaagtcatt gaccgtatgc agttaatctt agatattttt gccatgcgtg
     8341 ccagaagcca tgagggcaaa ttacaagtac accttgccca attgaaatat atgttacctc
     8401 gtttggttgg acagggcatc atgttaagtc gtcaagcagg tggtattggg agccgtggac
     8461 caggtgaaag ccaactagag ttaaatcgcc gttcgattcg tcatcagatt gctgatattg
     8521 aacgccaatt aactcaggta gagaaaaatc gtcaaacaat tagagatcgt cgtgtgggtt
     8581 cagatacctt taaaattggc ttgattggct acaccaatgc tggcaagtca accattatga
     8641 acttgttgac agatgacagc cactatgaag ccaatgaatt atttgctacc ttagatgcaa
     8701 ctacaaagca actctattta gaaaatcaat ttcaagcaac cttaacagac accgtaggct
     8761 ttattcaaga cttgccaacg gaattagtgg ctgcttttaa atcaacccta gaagaaagca
     8821 aatatgtgga tttgctgtta catgtgattg atgcgagtga tcccaatcat agtgagcaag
     8881 aaaaagtggt tttaaacctt ctaaaagagc tagacatgct taatattccg cgtttagcta
     8941 tttataacaa ggtggatata gcagaacaat tcacagctac tgcttttcca aatatcagga
     9001 tttcagcccg ttcaaaggat agcaaaattc tcttgagacg tttaatcatt gaccaaattc
     9061 gagaccagtt tgttcctttt agaatcaaag tgcatcaaga caaggcgtac aagctatatg
     9121 atttgaatcg agttgctctt ttagaccact acacgtttga ccaagaaata gaggatattt
     9181 cgggctacat ttccccaaaa cagcaatgga gacttgacga tttttatgaa taattatatt
     9241 gatttagcaa aaacctatgg tggatttact agtctggata ccaactacct aaaccatctg
     9301 ttagccagtt tgacagacca gcaaaaacta gcttttatca caccaccacc aagtgttatt
     9361 aatgcctact ttgctgaaat ctaccagaaa cagtcaccgc aagctgcgac tgattattat
     9421 tttaatcttt ctaaggcttt ggggcttttt actgaccaac catcttttga ggaagaaaag
     9481 ccctttgtac gcctcaattt gtctggaaaa gcttatggtt ttgcttacca aaatgaccaa
     9541 gaagttgcat tggtattttc tgaaaaagca gagcctaaga aacccgaact cttctttgaa
     9601 ttaacacaaa ttttcccaca atatatggtt tatgaagaca aaggccagct taaaatgcag
     9661 gctaagcagt ttgagcaagg agaatgtgaa gacattacgc ctgatgacac actcttgtcg
     9721 aagatttacc gtctggcaaa cggtatcacc atgcttaagg ggtttaatgt agaggagtta
     9781 tgggctctta gccaaacatt ttctggtcaa aagtattatg attttgccca acgagaattt
     9841 atgatttaca tcacccaata gaaagaatag attgaatgga attacaattt ttaggaactg
     9901 gagctggtca accagccaag cagcgcaatg tgtcaagtct tgccttgaaa ttactagacg
     9961 aaatcaatga agtctggatg tttgattgcg gtgaaggaac gcaaagacaa attttagaaa
    10021 cgacgattaa gccacgaaaa ataagaaaga ttttcattac tcatttgcat ggggaccaca
    10081 tttttggatt accaggattt ttatcaagtc ggtcttttca agctagtgaa gaacagacag
    10141 atcttgatat ttatggacca attggcatta aaacttacgt gttaactagt ctaaaagttt
    10201 ctggagcgcg tgtaccttat cagatccatt ttcatgaatt tgatgacaaa tcattaggta
    10261 aaataatgga aacagataag tttgtggtct atgcagagcg tctggcgcat accatttttt
    10321 gcatgggtta tcgagtagtt caaaaagact tagaaggaac cctagacgca gaagccttaa
    10381 aagcagcggg tgttcccttc ggaccactct ttggcaaaat taaaaatggt caagacgttg
    10441 agttggaaga cggccgcctg atttgtgcca aagattatat ttctgcccct aaaaaaggca
    10501 aaatcatcac cattatcggc gatacgcgca aaacgtctgc cagtgttaaa ctcgctaaag
    10561 atgcagatgt tttggttcat gaatccacct atggtaaggg tgacgagcgg attgcgagaa
    10621 atcacgggca ttctaccaac atgcaggcag cacaaatcgc tcatgaagca ggcgcaaaac
    10681 gcctcttgct caatcatgta tcagctcgct tcttagggcg tgattgtcgc cagatggaaa
    10741 aagatgccgc cactatattt gaaaatgtta aaatggtaca agatttagag gaagtgatta
    10801 tttaatggca caaagaatca ttgttatcac gggagcttct ggaggactgg ctcaggcaat
    10861 tgttaagcag ttacccaagg aagacagctt gattttatta ggacgtaaca aagaacgcct
    10921 agaacactgt tatcagcata ttgacaacaa agaatgcctt gagttggata ttaccaatcc
    10981 agtagccatt gagaaaatgg tcgcccagat ttaccagcgc tatggccgta ttgatgtctt
    11041 gattaataat gctggctatg gagctttcaa aggctttgaa gagttttctg cccaagaaat
    11101 agctgatatg tttcaggtta acaccctagc gagcattcac tttgcttgct tgattggtca
    11161 gaaaatggca gagcaggggc aaggccatct cattaatatt gtgtccatgg caggcttgat
    11221 tgcgtcagcc aaatcgagca tttattcagc caccaagttt gcccttatcg gattttccaa
    11281 tgcccttcgc ttagaattag cggataaagg ggtttacgtg accaccgtga atccaggtcc
    11341 cattgccacc aagttttttg accaagctga cccgtctgga cattatttgg aaagcgttgg
    11401 taaatttact ctccaaccaa atcaagtggc taagcgtttg gtttctatta tcgggaaaaa
    11461 taaacgagaa ttgaatttgc cctttagttt agcggtgacc catcaatttt acaccctttt
    11521 ccctaaatta tctgattatc ttgcaagaaa ggtatttaat tataaatgat taaatccaaa
    11581 tatagctgga aaataaaaga caagaagcca gatgatggct tctttaagct agcaaagaca
    11641 aaaggtctaa cccagaccgc cgctcagttg atttatgagc gagggataag gactgaagaa
    11701 gccttagatg agtttttaac agcggacttg tctcaactgc atgatcctta tttgctacat
    11761 gacatggcaa aagctgtgcc aagaattcgt caagctattg aagagggcga acgaattctc
    11821 atttacggcg actatgatgc tgatggcatg acgtcggctt ctattgtcaa agaaacccta
    11881 gacatgatgg gagcagagcc tttggtttat cttcccaacc gctttacaga tggctatggc
    11941 cccaaccaga gcgtctataa atattttatt gagcaggaag ctgtgtccct aattatcacg
    12001 gttgataatg gcgtggccgg acatgaagcg attagatatg ctcaagaaca ggaagttgat
    12061 gtcattgtaa ctgaccatca tagcctgcct gaagaattgc cagaagcctt tgccatcatt
    12121 catcctgagc atcctgatgc tgattatccc tttaaacact tagctggctg tggcgttgcc
    12181 tttaaattgg caacagcttt gctagaaagt ttaccaacag actgtctaga cttggtagct
    12241 attggaacca ttgccgatat ggtaagcttg acaggtgaaa accgtgtttt agtcaaaaat
    12301 ggtctggcca tgctcaaaca caccgaaaga gtgggcttgc aggagttgat gtccttgtct
    12361 cctattgatt tggaacattt taatgaagac gccattggct ttcagattgc tccgcaatta
    12421 aatgctttag ggcgcttaga tgaccctaat ccagccattg agctactgac gggctttgat
    12481 gaccaagaag ctcaagcgat tgccttgatg attaagaaaa aaaatgaaga gcgtaaggcc
    12541 ttagtccaag acatttttga tcaagcgatg gctatggttg atcctcaaaa acctgttcaa
    12601 gtcttggcac aagctggctg gcatcctggt gttcttggga ttgtcgctgg tcgtatcatg
    12661 gaaactattg gacaaacggt cgtcgttttg accattgata atggctttgc aaaaggctcg
    12721 gccagaagtt tagaagctat taatattttt gaagccttga atggcaagcg tgagttattt
    12781 acagcttttg ggggacatgc tggtgcagca ggaatgaccc tgcccgttga caacttggaa
    12841 gctctctcag actttctttg tcagtttgtg atagaacgtg gcttagatca gactgccaaa
    12901 aatacgttaa ctattgatga aagactgtct ttggacgacc ttagccttga tattttaaag
    12961 agtttagata aattagcccc ttatgggatg gatcatcaaa agccggtctt ttatgtcaag
    13021 gacataaggg ttagtcaagt gcgtaccata gggcaagacc agagccatct taaatttaaa
    13081 gtcagtcagg gcaaagcttc ctttgacgta ctggcttttg gtcaaggaag tcaactgcaa
    13141 gagttccgac aagctactgg tttagaatta gcagttacct tatctgtcaa ccattggaac
    13201 gggaacacga gtctccaatt catgttagta gatgctcgtg ttgacggagt gcaacttctt
    13261 gacttaagga caaaaacagc caaagttcct gaaggtattc cgactattga agaagatcca
    13321 aatgccagag tcattctgat taatgacatc cctgaagatt tcaaaacctg gcgcaaccag
    13381 tttgttcaca aggattttga cgccatctat tttaaaaatc agatgaaata tccttattat
    13441 ttaacaggat ttggcagcag agagcagttt gccaagctct acaaaaccat ctatcagttt
    13501 cctgaatttg atttacggca taaattgaca gagttgagtc actatttaaa catagaaaaa
    13561 cttttactga ttaagttgat tcaaattttt gaagagttgt cttttgtgac gattgacgat
    13621 gggctgatga cggttaaccc ccaagcgcaa aaacgagaga tttcagagag ccacatttac
    13681 caagacttaa aagaattggt gaaatttcaa gaaatcatgg ctttggctag cccgaaagag
    13741 atgtatgatt atttggtgaa atcaaacgat caataagtaa agcagttgac agtagttatt
    13801 gaggtagtta cgaatgaagt atcagataaa caataatgtc agaagtctta ttttacgaaa
    13861 aatatgtttc gtgatataat gaagagtatt ttatatttgg caatttgcca ctagaaagaa
    13921 ttaactatgg atttaacaaa ttacattgca tcgatcaaag attaccctaa agctggtatt
    13981 acgtttcgag atatctcacc tttaatggct gacggtaaag catatagcta tgctattcgt
    14041 gaaatagcac agtacgcttg tgataaagat attgacatgg ttgttggacc tgaagcgcgt
    14101 ggttttatca ttggttgtcc tgttgcagtt gagttaggaa ttggttttgc tcccgttcgt
    14161 aaaccaggaa aactgccaag agatgttgtc tctgctgatt acgaaaaaga atatggtctt
    14221 gataccttaa ctatgcatgc agatgctatt aagcctggac aacgtgtttt gattgtcgat
    14281 gatttactag cgactggcgg tacggtaaaa gcaactattg aaatgattga aaaacttggt
    14341 ggtattgtag ctggttgtgc cttccttatt gaattagaag gtttaaatgg tcgccatgct
    14401 attaggaact atgactataa agtcttaatg cagtttcctg gataagcaca ttaatcagca
    14461 tctgattagg ggatttaaag tagtaaaggc tatagattcg attttagcct tttgattgag
    14521 ggattatgag ttttttagaa cattataagt caggtaattt ggtcatccca agtgccttgc
    14581 tttttcatta caaagatctt tttaagagct cagatgattt tttggtctgg cagtttttct
    14641 atcttcaaaa tacgacaaag cgagacgact tagcgcccag tcaaattgct catgcgcttg
    14701 gaaaatcagt tgctgatatt aataaaatca tttcatcttt gactagtcaa gggcttttag
    14761 atatgcggac aattgaactt actggagaaa ttgaaattat ttttgatgcg agtcctgtgt
    14821 tagccaagtt agatcaattg tttgtcagtc aaacggcaac tgaaattgac aaacaagaaa
    14881 caccaaacca tttcaaacga ttagttgatg aatttgaacg tgaattagga cgattcttga
    14941 gtccttttga gttagaagat cttgaaaaaa cgcttcgtga tgataaaaca gatcctgatt
    15001 tgatacgaga agctttaaaa gaagctgtct tcaacggcaa aacaaattgg aaatatatcc
    15061 aggctatctt acgtaattgg cgaaaagaag gtattgttaa tcttcgacaa gtagaagaac
    15121 gtagacgtgt tagagaaggc gaagatcttt ctcaagtgac gatatcagat gattttctat
    15181 ctgcgatgaa tttatggagt gattcatgag aattggaaaa gcaagattag caaaagtcct
    15241 gaccatcatt ggtcaaatgt ttcctgaggc taagggagag ttagactggg aaacaccttt
    15301 tcaattgttg attgcggtga ttttatcagc tcaaacgaca gataaggccg tcaataaggt
    15361 aactcctgga ctatggcagt cttatccaga aatagaagac ttagcttttg ctgaactttc
    15421 tgatgttgaa aatgctctga gaacgattgg actctataaa aataaggcca aaaatatcat
    15481 taaaactgct caggctattc gtgatgattt taagggtcaa gtgccaaaaa cccacaaaga
    15541 acttgaaagt ttaccgggtg ttggccgaaa aacagccaat gtggtattgg cagaggttta
    15601 tggtgttcca gctattgcgg ttgatactca tgtggctaga gtctcaaaga ggctcaatat
    15661 ttcatcacca gatgccgatg tcaagcagat tgaagcagat ttgatggcta aaattccaaa
    15721 gaaagattgg attattactc accatcgatt gattttcttt ggacgctacc attgtttagc
    15781 caaaaaacca aaatgtgaga tttgtcccgt tcagtcttac tgcaagtact atcaaaatac
    15841 ttatggaaaa tcgaaagcct agcctttggt tttctttttt tatggaggta attttgctat
    15901 aatagaatca ttacgtttta gaaagaaatc aagatggata gtcaattatc aaaccgtttg
    15961 gcccaagttg cggcctatgt tccaaaaggt gtcaaattat tagatgttgg cagtgatcat
    16021 gcctatcttc ccatattttt ggtagaaact aatcagattt cagcagccat tgctggcgaa
    16081 gtggttaggg gtccctacga atctgctctt aaaaatgtca cacagtctgg ccttgccgag
    16141 catattcagg tgcgcttagc caatggcctt gcagcctttg aagaagctga tgatgtgaca
    16201 gccattacca tttgtggcat gggtggccgt ttgattgctg atattttaga ggcaggtaag
    16261 gaaaaattac agggcattga acgtctggtt ttacaaccca acaatcgtga ggatgattta
    16321 cgggcttggt tatcggttaa cgcttttaaa attgttgcag aaaccatcat ggctgaaaat
    16381 gacaaatatt atgaaatcat cgttgctgag catggtgaaa aggccttatc cgcgacagaa
    16441 ttgcgttttg gtccatacct ttctcaggaa aaatcagtcg tttttaaaga gaagtggcaa
    16501 cgagaaatgg ataagttagc ttatgccttg tcctgtatcc cagaagaaaa aactcaagag
    16561 cgtcagcttc tcttgacaaa aatacaacaa ataaaagagg tgattgttca tgaaagctaa
    16621 aaccctaatt gatgcctatg aagccttttg cccacttgat ttatctatgg aaggagacgt
    16681 taaaggtctt caaatgggtt cattggataa agacattcgt aaggttatga ttactttaga
    16741 tatccgagag tcaacagtag cagaagccat caaaaatgaa gttgatttca ttataactaa
    16801 gcatgctccc atctttaaac cgcttaaaga tctggtttca tcccctcagc gtgatatcct
    16861 tctagatttg gtcaagcatg acatttctgt ctatgtgagc cataccaata ttgacattgt
    16921 accaggtggg ctaaatgatt ggttttgtga cctgctagaa atcaaggaag caacttactt
    16981 gtctgaaacc aaagaaggct ttggcattgg tcgtattgga acagttaaag aacaagcgtt
    17041 agaagagtta gcaagtaagg tcaaaagggt gtttgattta gataccgtgc gacttatccg
    17101 ttacgataag gaaaaccctt tgatttcaaa gattgctatc tgtggcggaa gtggtggtga
    17161 attttatcag gatgctgtgc aaaaaggcgc agacgtttat attacagggg atatctatta
    17221 ccatacagca caggagatgc tgacagaagg actatttgcg gttgacccgg ggcatcatat
    17281 tgaggtgctt tttacggaga aattaaagga gaaactccaa gggtggaaag aagagaacgg
    17341 ttgggatgtc agcattattt caagcaaagc ctcgaccaat ccatttagcc atttataggc
    17401 tgttaaggtc ttaaaataag ataaaaggat accaggaatg aaaatagcca ttattggggc
    17461 ggggattgta ggatcaaccg ccgcttatta tttacaacaa agtggtcaaa aagaagttac
    17521 catttttgac catggtcaag gacaagccac taaggctgct gctggtatta ttagtccttg
    17581 gttttcaaag cgtcgcaata aagtttggta tcgcatggct cgtttaggag ccgattttta
    17641 tcaacagtta gtcagcgact tacagactga tggctttgca acggattttt accagcaaaa
    17701 tgggatttac ttattaaaaa agcaagagga gaagttaaaa gatctttatc aattagcttt
    17761 aagtagacaa gaagaatccc ctttaatcgg tcatttggaa gtaaaaaaac gtgaggagat
    17821 acaagaggca tttccaggct tagttggctt tgataactgt ctgtacgctt caggagctgc
    17881 tagagtggag ggagccgctt tatgtgagac gttactcaag gctagtggtt atccagttat
    17941 tcgccaaaaa gtcactctga aacagcaagg aagtggttat gagattgctg gtcattattt
    18001 tgatcaggtc attctggcag caggagcatg gctacctgac ttattgatgc ctttaggcta
    18061 tcaggttgat gtgcgaccac aaaagggaca actcttggat tatgacgttc atcacatcat
    18121 cagcgacact tatcccgttg ttatgccaga aggtgaaata gacctcattc ctttcaatca
    18181 aggtaagatt tctgttggtg cgagccatga aaatgataaa ggttatgatt tggagcctga
    18241 ttggcaggtc ttagaaaaac ttgaaatgca agctctcact tatttgccgt tattaaaaga
    18301 agctactcaa aaatcatgtc gtgtagggat aagagcttat accagtgatt attctccttt
    18361 ttatggtcag gttccaggat tgaagaacct ttatacagct agtggtttag ggtcatcggg
    18421 attaacagtt ggacctttga ttggctatga attagctcaa ttattgctag gacacgaagg
    18481 acttttgacg cctagcgact attcccctga gccttacctt ttgcggtcta ctggtaaagc
    18541 gtgacactgc tttcaaaaaa tgatagaatg atagggtata tagaagaata ggagcactac
    18601 tatgaaaggt attattcttg caggaggttc agggacacgc ttgtatccac tgacccgtgc
    18661 cgcatctaaa cagttgatgc ccatttatga caaaccaatg atttattacc cattgtcaac
    18721 cttgatgttg gcagggatta aagatatttt aatcatttca actccccaag atcttcctcg
    18781 tttcgaagaa ttgctaggag acgggtcaga atttggcatt agcttatcct ataaggaaca
    18841 accaagccca gatggtttag cacaagcttt cattattgga gaggagttta tcggtgatga
    18901 ccgtgttgct cttattttag gagataatat ttaccacggt aatggcctca ctaaaatgct
    18961 tcaaaaggca gctgccaaag aaaaaggagc caccgttttt ggttatcaag tgaaagaccc
    19021 tgagcgcttt ggagtggtgg aatttgatga gaacatgaat gctatctcta tcgaagaaaa
    19081 accagaagtg cctaagtccc actttgcagt gactggactt tatttctatg acaatgacgt
    19141 ggtagagatt gctaaaaaca ttaaaccaag cgcgcgtggt gagttggaaa ttacagacgt
    19201 caacaaggct tacttggaac gtggtgacct ctccgttgaa ttgatggggc gtggttttgc
    19261 atggctagac actggaacgc atgaaagtct acttgaagcg gctcaatata ttgaaacagt
    19321 tcagcgcttg caaaacgctc aagtggcaaa tctggaagaa attgcctatc gcatgggtta
    19381 tatcagtaaa gaagatgtcc ataaattggc gcaatcttta aagaaaaacg aatacgggca
    19441 atacttgctt cgtttgattg gagaagctta atgacagaaa ctttttttga caaaccattg
    19501 gcttgccgag aaatcaaaga aatcccaggc ttactagagt ttgatattcc tgttcgtggg
    19561 gataatcgtg gctggtttaa agaaaatttc caaaaagaaa aaatgttgcc aattggcttt
    19621 ccagaacgtt tttttgagga aggaaaacta caaaacaacg tttctttttc acgtcagcat
    19681 gtgctgcgtg gacttcatgc tgaaccttgg gataaataca tctcagttgc tgatgatggc
    19741 aaggttttag gagcttgggt tgatcttcgt gagggagaga cttttggaaa cgtctaccag
    19801 acagtgattg atgcttcaaa aggaatgttt gttcctagag gggttgctaa tggctttcaa
    19861 gttctttcag agactgtctc ttacagttat cttgtcaatg actactgggc tcttgacttg
    19921 aaacctaagt atgcttttgt aaactatgct gacccaagtc ttgggattac ttgggaaaat
    19981 ctagcagctg cagaagtttc tgaagcagat aaaaaccatc ctcttcttag tgatgtcaaa
    20041 ccactgaaac caaaagacct atagggaaac aacatactca gatgattggg attaatcatt
    20101 tgaggtggat atgaggggag ttattcttct ctacctcagg taacaagtaa caactaaaaa
    20161 tgatgaaagg aaagttcagt ttctctcttt gagctgaaca tgggactcaa atcttagaaa
    20221 gcaatgtttt cttagaccta aaacgtcttt gttagagtca ttacttttaa tagatttttt
    20281 cggaaacgaa aggtccctct atatcttatg tataaaaata ttatcgtaac tggtggagct
    20341 ggtttcatcg gttctaactt tgtacactat gtctacaata accacccaga tgttcatgta
    20401 actgtccttg ataaattgac atatgcaggt aaccgtgcta acattgaagc tattcttggt
    20461 gatcgtgttg agttagttgt tggtgatatc gctgacgctg aattggtaga taaattggct
    20521 gccaaagcgg atgctattgt tcactatgcg gctgagagcc acaacgataa ctcattggaa
    20581 gatccaagtc catttatcca tacaaacttt atcggaactt acactttgct tgaagcagct
    20641 cgtaaatacg atatccgttt ccaccacgtg tcaactgatg aagtttatgg agatcttcca
    20701 cttcgtgaag accttccagg acagggcgaa ggaccaggtg aaaaattcac tgctgaaaca
    20761 aaatacaatc catcatcacc ttactcatca actaaggcag cttctgacct tatcgttaag
    20821 gcatgggtac gttccttcgg tgtgaaagcg accatttcga actgttcaaa taactatgga
    20881 ccataccaac acatcgaaaa attcattcca cgtcaaatta caaatatctt ggcaggaatc
    20941 aaaccaaaac tttatggtga aggtaaaaac gtccgtgact ggattcatac taatgatcat
    21001 tctacaggag tatgggctat tttgactaag ggtcgtatcg gtgaaacata ccttattggt
    21061 gccgacggcg agaaaaacaa caaggaagtt cttgaattga ttcttgaaaa aatgggtcaa
    21121 ccaaaagacg cttatgatca cgtaactgac cgtgctggtc acgatcttcg ttacgctatt
    21181 gattctacaa aattgcgtga agaactcggc tgggaaccac aatttacaaa cttttcagaa
    21241 ggtttggaag aaactattaa gtggtacaca gaaaatgaga catggtggaa agcagaaaaa
    21301 gatgctgtag aagccaagta tgctaaaact caagaagtga ttaaataaaa cattaaagag
    21361 ccttgtcata tcaacgtttg ttgaagatgt caaggttttt tcttgtgttt tggggcattt
    21421 ttggggcata ttatagccga tttaagatgt cgacgacttc atttttcatg cttttcgtga
    21481 cgtgggtata gatttgttga gtagttttcg agtcagcgtg tccaactcta tccatgatag
    21541 tttttaaggg cactttgttt tctgcaaggc gactcaccag ggtatgacgg aagatgtggc
    21601 tggtgagttc tttttgaatc ggtttttcta gtctcttatt tgccgctctg atagaggtgt
    21661 tgagggcgtt gtcttgaata ggaacgccat ttctggaaat gaagatgtag cccatgtcct
    21721 tgtaattagg attagtattt ttttcaagag cattaatttt cagtatatcc tgaataattt
    21781 ctttttcacg tttggttatc aatgtttcac gccaactgga atttgtttta ggggtggttt
    21841 tgatagcgtt tctatagcca tttgaggtgt agtcaagagt tccgtggatt tcaatgatat
    21901 catttttgat attgtctggc tgtatagcta gagcttctcc aatgcggcag ccgtttaagc
    21961 tcataaattc tgccagataa gccattttaa tcgatccttt acgtctatac atttcatcta
    22021 atagcctttt gagttcatct ttttctaaaa acttctgggc aacgtcttca aagtctttga
    22081 tggtcttaac aggttttgcg agttgggtac taataactgg attgattgag acatactcta
    22141 aagcgatagc gtagtcgaag gtttgtttga gcagctgccg tgctcgttta cgtttgtcat
    22201 aactacctgg tattttgtcg ataatacttt gcaggtattt cgtggttacc ctggcaatca
    22261 tcacttctgg atcaattaag tttcgcaatt ctctgattct aaaatcaaga gagcggacag
    22321 aagttgattt gagtgatttc tgatgatgtt cccaccattc gttcatgaca tctagtaggt
    22381 aggcatatat ataaagagag ttgaaaaatg cggtaactcg gtaaccaaat caccaaatag
    22441 cttgggagag taaggaggag aaggacaccg caaccggtaa ccaagtgagt aaccggtgtc
    22501 cgaaataatt atatgacaac agaatcacta atccaaaacc aaatccgtgt tgctctatca
    22561 aaagcgggcc atatggtttt tagagctaac gttggtaaag tcaaaacagt agacggtaga
    22621 ttatttgata cgggactacc taaaggtttt tgtgacttgt ttggatttaa gccagacggg
    22681 caaatattct tcattgaagt aaaaaacgaa acaggtcgag taaggcctga acagaaaaaa
    22741 tttatggagg taatggcatc taggggagct ctggtaggag tagctagatc tgtggaagat
    22801 gccttaaaaa tagtcaatga cactagtaga tgatttttac aaacaaatgg agccgtcaat
    22861 caaagcgttt ttagacgata acattaccat cgcagacaaa gaagaagctg acagagtcta
    22921 tagatctgtc aaatactata aaaaactaaa cagattgccg ccacctgatg tattggagtg
    22981 gttccaacga atctacacga cagaggaaat gataatgtta atcaagcagt cttaccgcct
    23041 taaacaaaaa aagacagatg aggatgacaa gatttacgaa aagtggatgt ttaaaaacta
    23101 cggtgacgtt aagctcgtta aaaaaatcaa acgcataaac gcattagcta aggctcggga
    23161 gatgggtcta tgaaaagaca cagacagtgg cataacgata ttaaatatac acctagatct
    23221 tacgataatc tgttgcctta cgatatatca gagctgttaa tagctcacag atgcaaaata
    23281 aagatgtctg atgacgtttt agcggacagg ataggtattt atacttggca attaaaagcg
    23341 ctcttagaac gcagaatatt gccaaatgag agcgtgtgta aaacgatagt aaattatttg
    23401 agggaggtgg agagatgctg acggaagata ctgatgcaga taaaaccaaa aatgcagtag
    23461 aagcgttttc tgaggcattt tccgaagcaa tcgaaaaaga agtcaaagaa cgccttaaat
    23521 cgccaacacc taaaaaatca aatggcaata ctggactgac aaaagaacaa attttagcag
    23581 tcaaagatac tgcggaacga caaaaactca ttgccgaaaa tatcggccta ttccaataaa
    23641 acaggagaaa ttaacacatg gtaacatcac gtacttaccc agaagaaaat ctaatcaaat
    23701 caacagacct taaataccct atcactattg atgtcacaaa caaattccaa gaaaatatct
    23761 cgaaattact tgaaatgctc ggggttactc gtaaaatctc ggtatctgtg ggtatgaccc
    23821 ttaagacata cgctggttat gatgtcacat tagcagaagg taacgtccca gaaggcgaag
    23881 ttatcccgtt atcaaaagta gagcgcaaaa tacactctga gaaaaaaatc gaacttaaaa
    23941 aatatcgtaa agcaacaacc ggcgaagaca tccaaatgta tggctctaac gaagctgtaa
    24001 caaatactga caacgcactt gttcgtcagt tgcaaaagaa aatccgcaca gactttgtga
    24061 ctgctcttaa aacaggtaca ggaacacaag atgctcttgg tgcaggattg caaggggctt
    24121 tagcttctgc ttggggtaaa ctgcaagtgc tctttgaaga ttatggttca gagcgtgcga
    24181 ttgtgtttgc taatagcctt gatgtcgctg aatacatcgc taaagctggc atcactactc
    24241 aaaccgcatt cggattgact taccttgtcg attttacagg gacggtcatt atctcgacaa
    24301 acgatgtcac aaaaggggaa atctgggcga cagtaccaga aaatatcatc tttgcttaca
    24361 tcaatccaaa taattctgaa ttagctaaag aatttaatct ttacggtgat ccaaccggct
    24421 acattggaat gaatcacttc caagaaaata caacgcttac tatccaaacg ctgcttgtat
    24481 ctggtatgtt gatgtatcca gaacgcattg acggaattgt taaagtaact cttacaccag
    24541 gcgtctaagg gggtaatcta tggcttacac agtaaaagca cgtttttttg acttgcttga
    24601 caatagcttt ttgtacgagg ttggcgacag ctttcctcgc aaaggctatg agccaagcaa
    24661 agagcgctta gaaagcttgt tatctagcaa caatacagaa cataaaccat ttattgaggt
    24721 gtcaggtaat ggcaatagct tagatggttt aaaagtggat gagttaaaag ctaaagcggc
    24781 agagctagga atcgaactcc caagtaatgc taaaaaagct gaaatcatcg aattactgca
    24841 agcacatatc tagaaagtag gttgacatgg acgaaacaaa acaagcaatt attgatcgtg
    24901 tccgtgtccg tttagcagac gaaacgtctt taaaagagga gttattggag gagttaacgc
    24961 aaacggctat cgaccgtatt aatttaaaag tcggcgatgt cgtttttaac cctcttttta
    25021 attccattac tgttgatgtt gttgtcaaaa tgtatcgtcg tatgtatttt gaaggaattg
    25081 acacggaaaa agcagacaca atatcaacta aatttattga aaacgttttg gcagaatatg
    25141 gcgaggagtt agcgtcgtat aaaaaggacc gtctagccgt cttaaataaa aaggtggtgc
    25201 ggtttttatg agatttgtta attttgactt agtaacccca caaaaaacag ggaaaaaaga
    25261 taagcttggc aatgacatca ctaaagatgt cgtcaagcgt gacgctaaag gtcgttttac
    25321 tgaatggtcg gctgatgacg tgtccttata cggtcgagat ttaacgtcta gtgcacgcaa
    25381 attgctgact aatcaagtta gcaaggcgga agccaaacaa gcgtcacacg ttgtaataga
    25441 tggctcaaaa tacaaagttg aatccgttaa agatcttggt agatggagac tactcgtcat
    25501 taaagggtat cgcttatgag gatgtcaatg acaggtatgc cagccttaga ggtaaaacta
    25561 aggtcaatga gcgataagcg ttgggatagg gttgtcaaca aaaacctcac agagatgttt
    25621 aacagatcag caagaccgcc tggtacaccg attggtaaaa acactaaaag gcataagtct
    25681 ggcgagttgt tgcgctctag acgtctcaaa aaggtaaact catcaaaagg tgttatcaca
    25741 ggtaattttg gatatatcaa ggactatgca cctcatgttg aatacggtca tagacttgtc
    25801 cgtaacggta aacagattgg ctatgttaac gggacaaaat acctgtttaa taacgtcaaa
    25861 aaacagcgtg aaatttatag gcaagacatg ctaaacgaat taaggaaatg acatgttaaa
    25921 aaaactggga ctggttgatt tacatgcctc aattaaacaa aaaattgaag ataagacagg
    25981 gttgatggct tatgatcacg taccagaaga catgccatcg cctttttatt ttatcgaggt
    26041 tgtggataag cgaccagaag acacaaaggt catgtggtgc gaagtgttta cggtttggat
    26101 acatgccata gcggaagctg gaaaaagcaa aatcgctatt tatgacatga ttgaaaaact
    26161 cgaagaagcg ctcacagaag aattagtttt gccagaagaa atcgacattt tgagacaatc
    26221 agaagtcggc atgcagtcct tgcaagagga cgaaactggc gaaatgcatg caattgtagc
    26281 ctacgaaatc aaggtttcgt acggttttaa agtaaaaatt taaaaggaga aataatagtg
    26341 gcatttgatc aaaatgttta ttgtaatttt gacgcgtcag caacaaaagc tattgtttgt
    26401 attaaagtta ttaacggtaa aaccaaaaaa ggcatgtttg gagggcttgc gtcggtaagt
    26461 gattatagtt tagaagctcc ttacgatgat ggtatgacat actcaatcag tctcgaaggc
    26521 aatggagcat tgattgattt atcaacatta tcatcagaag atgctggaaa agtaacggct
    26581 atgcctagtt aatgagagga atgaatggat aaagaattaa ttattatcga tgaaaaacag
    26641 tacgaactaa agtacaacga aaaaaccatt gaaaccgtcg aagctttaac tggcaaagcg
    26701 tttatggatg ttattgtaaa taacaaaggg atgttgtcgt tatctatgtt gcggcaatat
    26761 ttttccaatg ctctttatgc ggtagaaggt ggtcgtgtgt ctagcgagca aggctcaaac
    26821 gtttttacta aagtgttaaa cacaaaaggt tatgtttacc ttgccagcgg tcgctggtat
    26881 aacagcagtt gttaaagagt atgcaaacct tgaacagtca atcggtggtg ttgagacttt
    26941 gtttaaaaag tctgctaaag ctgtgcaaaa aaatgcaaat acagcgttta gacgagctgg
    27001 tgtatctgct aatgagtaca tggagcaagt aactagcttt tctgctagtc taatttcatc
    27061 tcttggcgga gatacagcaa aggctgtcgg tgttgctgat actgccatgg tcgacatgtc
    27121 tgacaacgct aataaatttg gtacaaacat cgggttaatc caaaatgcct atcaaggctt
    27181 tgctaaaggc aattacacga tgttagataa ccttagattg ggttttggcg ggacgaaaga
    27241 ggagatgcaa agattgctgg acgaagctgg taagctaagc ggcatggaat ttgacatcaa
    27301 taacttttcg gacattatac aagcaatcca cattatccaa gataatttag gcgtaacagg
    27361 aacgacagct agagaagcgt cagaaactat tagcggctca ttttcgcaag caaaagcgtc
    27421 agtaatcgat ttcatgggct ctcttggcgg agatggcagc gatgtagatg caaaaatgca
    27481 agcaatgata cagtcgatta ctgtgtttgc agataatgtc aaagaggctt tagggcgcat
    27541 ttgggacaat ttgcctttac aagagtatca aaaaaaccta ctgcttatag ctgtcgttgg
    27601 cggacctatc cttgttgtgg tcgggactat ttttggagct attgctaata tcatgactgt
    27661 tgttagcggt attttaaccg ttctaggcat gatgacgcca ataggttgga tcatagtggc
    27721 agccatagcg gctattgtcg cagctgtcgt tttttgggac gatattgtcg cagaggtcgg
    27781 ccaaaaattt gagttagtca aaataatcgg catggcgatg tgggaaagtt ttaaagatgg
    27841 tgtatctagc tttggcaagt taatccaaaa tgtcgttggc aaaattggcg gatggtttgc
    27901 agaagcgtgg aatactgcat cagacacagc tactaggatt tttactaggg ttggagagac
    27961 gatcagtggt atctttagcg gtgttgtttc tggcattaaa agtttgataa atggggcaat
    28021 cggtggcatc aataaggtta ttggcattac taacaaactg cccggtgtca acatcccaaa
    28081 aatcccatac cttgcacgag gtacatctga ctggcaaggt ggtcttgctc gtattaatga
    28141 gggcggacga ggggaattag tacacatgcc aaacggtacg acagtagtgc cgcatgacgt
    28201 aagcatgaaa tacgctcgag aatctgctaa agccaattct ggcattgctt atgttgatag
    28261 caatgatgag attgccaaaa gcgccttgaa attagctaac gatgctatta aacgccctgt
    28321 tgtgttaaat atcaacggcc gtgaggtcgc tagaacaaca ggtggagaca tgagagacta
    28381 cctaaatagt cgagatatga cattaaaacg attgagaggt gaggtttaga tgactacaat
    28441 gacttttaat gatgtggact tatctagcct catcactatc atgtctgtca atcgagacat
    28501 cggtaacgag agacaagccg aaactaacga cgctccattt gttggtttgc atgtaaaaaa
    28561 gataaagact agcgcaaaaa taattacagt tgatttttat ttaaaggaca ggacaaacga
    28621 gtacgcatta aaccagctaa aacacaaatt agctggtatt tttaatgtca acgagcaagt
    28681 caaggtgact tttagcgatg agcctgacaa atattatcta gctataccga taaataaaat
    28741 atcggctagc gacccaatag cttggctaag tcttgtgagc ttggagctac ttgtccctga
    28801 tggcgtggcc cattctgtgt cctataaaaa aatcacgaat tacagacaag atggtaagaa
    28861 gctgctgatt gacattacaa acaacggtaa tgttgatgcg catccgatca ttactgttaa
    28921 gcacaacgcc gagaatggtt atttagcttt tgttaataaa tcatccgttt tcgaggtcgg
    28981 agacagggaa atagcagacg ctgaaatccg tgaaaagtcg gtcgtcgctt atgattttaa
    29041 agacgaaaga atagtcaatg ccttaacagc aggtaaaaag aatgttgcta tcttaaatga
    29101 ctcgacacaa gttcttgata aaaatttatt actaaatacc gtctggggaa gaaaacatct
    29161 cgagttagaa ggaagtgttg cgccaagtgg caaccatgct ggaacgttaa cgtttgatat
    29221 tcctgacgga ggtagcttat atgactatct ttggtggaga caaatttttt gggttgggac
    29281 tgtttcccag cttggcttta tcaaaatcat ggtatcagac gaaaacggac attttttata
    29341 tggagtagaa actataaaaa gaacgttagg aacaaaaaca gagtataact ttttggtcac
    29401 taatggaaaa ggtggatata aaataactga tttacgttgg acttttgatg ctactcactt
    29461 cgaaacacaa aaccccttta acgaacccag aggttggtct gatatgacaa gggctgatga
    29521 cactgtatct gttttttggt ggggttctca aaacaagcga gtattcccag aattaaaagg
    29581 caaaaaatct aaacaggtac acatcgcaat cggcactatt caaggcagtc ctttagtaac
    29641 tcacatgtat attgatggat tttattatcg caaggacaaa gtaccgtacg aatttaatat
    29701 tccgaatgct ttcggggcag gaacagaagt cgttattaat gccgaaaatg acacagtttt
    29761 agttgataac attccaaaag ctaacatcat cgccgatggc ttttttagtt ttcctaaaat
    29821 tcctcctgga acatcaacat tagaggttta ttcctctagt tggtctaccg ccaacccaga
    29881 tattacgctc aattttgaag aaaggtggct ataattgctt ataacaattc acaacgcaaa
    29941 tttagaaaaa gttgcttata ttgataacga taagcaagac accttgaatt attatgacga
    30001 caaattttca cagtatttaa atacggccaa ttcgacattt gagtttacgg tttataagcg
    30061 aggaattaag tccgacacaa tcaaagagaa agcctatctg acacttacag aaaggtcttt
    30121 tgtgtcgatt aaatataatg gcaagtctta tctgtttaac gtaatgacaa cagacgagac
    30181 agacatcgag atacgttgtt actgcgagaa cctcaatctc gagttgctca atgagtatgc
    30241 aggaccttat agggcggcaa ctcagatgtc ttttgtcgat tattgtaatt tgtttggcat
    30301 ccttaaaaac ggtgctatta ccattggcac taatgagaca accgaccaaa aacgcacaat
    30361 cgaatggact ggtcaagata ccaatcttaa acgcttgtta tctatcgcca ataattttga
    30421 tgcggaaata gaatttgtaa cgcatcttaa aaacgattct agtcttaaat cgtttgtcat
    30481 gaatgtctac aagaagaacg acgctactaa tcaaggtgtt ggtcgtagac gagatgatat
    30541 tattttgcaa tatggcaaaa atatcgaaag tgtcagacgt aagattgata aaacaggcat
    30601 ttacaatgct ataagaccaa gcggtaaaat aacaacgact acaaccacaa cgactgctaa
    30661 acaaggctct gtgcaaacag ggtctgtttt gtggtctggc ggtaacttga cttatgcagg
    30721 ccatgtgatg caatcatctg ttgttaacac tattttaagc ctatgtagca aatacaagct
    30781 gttaccgtcc ggtgttttta gccagctgta ccttgaatca ttttggggag ataccccagt
    30841 cggaagagcc gataataact ggggtggcat cacttggact ggcgcaacaa ctagaccaag
    30901 cggtatcaat gtctcacaag ggcaacctcg agccgagggt ggtcattata accattacgc
    30961 aagcgttgat gactacttaa aagactatac ttacctcttg gcagagcaag gtatttatgc
    31021 cgtaaaaggt aagctaacca ttgatgagta cacaagaggt ctgtttaggg tcggtggcgc
    31081 aacatatgat tatgctgcag ctggatatga tcattatgca cctttgatgc gagacatcag
    31141 agcaggtatt aaccgtaata ataacggcgc tatggataac gtcgataacc aatttaaaaa
    31201 tggcggctcg actagtcaaa atactactca gatagctgct aaaacaaaag cggtacttgc
    31261 ggaagcaacc ggactgaaag gtcaacgagt aggctctggt cagtgctatg cgttagcagc
    31321 ttggtacgca atgaaattag atgggccagg tctaaatggt ggtgtaacta gttttagagg
    31381 acttattggt gctggtgcag cagctgctca gattggtacg gactacaact ggggtcagtt
    31441 tggctggaaa gttgtacaac cgaataaagt cgcagactta atcacaggct cgattgttaa
    31501 catcagagca aacgctggca gtcctgtttt tacaggcgct tgggggcata ctgttgttgt
    31561 taaatctcta tctggagata cgctcacagt cttagagcaa aactataaca acgtgcaaac
    31621 agtccaagag catacatata gcgctagcgc ttatttatca gttgtacaga cagtctgtta
    31681 cccgccagaa atcgttaaag ggagacgtgt cgaaggcact gcacaagcag aacagccaca
    31741 accagaaaca accacgacat ctgaagaaaa agaggtttta attaacccat cgctttaccg
    31801 tgagtggaaa aacgaatcag gacaagtcga attttacgtt aaaaacagca tgctctatgc
    31861 acctttgtct aaatcgcttt atccatcagc gtttacagga attgaaactg acgataattg
    31921 gatacgaaaa gacttagatg ttgatacaga aagtgaagaa aagcttatct ctgttgctct
    31981 cgcagatctg agaaaacatt gttatccagc ggtgacctat gaagtatctg gttttattgg
    32041 tgatttagat attggtgaca ctatcaaaat caatgatcca gaatacacgc caagcctaat
    32101 tttagaagca agggttagcg agcaacacat ctcgtttaca gagcctaatc aaaataagac
    32161 cgtctttgat aattacagag ctttagagag caaagtctca caaggtttaa ttgaccgcat
    32221 gaacgaacta gcagaagctg ctaaacctta cgacttgcgg ttaatgacag ataacggaaa
    32281 tgtgttttta aacggcgaag gtcgtacgat tttaaccgct gaactttgga aaggtaacaa
    32341 aaagtttgat gcaagctatc aatttaaacg tgatggtcaa ttagtcggcg ctggattgca
    32401 gttggcagtt gacgctaagg atgtaccagc tgataaacct ctaatcatta ctgttgaggc
    32461 ttatttaaat aatgagctga ttgcaagtaa acagattacg tttactaact cgcttggaga
    32521 acaaggacca gctggacgtg ggattgtctc tacagaggac tattacttag cgtcaccaaa
    32581 tcgtacaggt gtcacatctg caacatctgg ttggactaag acgcctcagg aaattactga
    32641 gactaataaa tatcattggt attatcacgt tgatgtttat tcagatggca ctcgaaaaga
    32701 gactacaccg gctattattg gtgtttacgg cgataaaggt tcagatggca agcaaggaga
    32761 aaaagggaac gatggtccaa tgggtccgca aggtcctgcc ggagcgctag atgaaaagca
    32821 actacaagac atcaataata aaattgatgg caaagcagac cagaatttga ccatcgagca
    32881 aatcaataaa ttagccgagt tacaatctat tgccaacgct gagttacaag caaaggctag
    32941 catcgacgct ttagctagct tacaaaagca agtacagtct gcaatagcgg caatgaatgc
    33001 tagccaaaag ttatcagagc aagaccttat tacagctagt caacgtgcta tcaaagcaac
    33061 caacgacatc ttagacttaa aagagcaatg gaattttatt gacaattata tgtcagcgtc
    33121 tgaagaggga cttattatcg gctctaaaga cggtacaagt tccgtgcgtg ttgccaaaga
    33181 ccgtattgcc ttttactcag ctggcgcaga agtcgcttcg attactggtg gtatgctcaa
    33241 aattgataat ggtatgtttg tggctacttt gcaagttgga cattttcgcg aggagatgta
    33301 caaagttgat ggggtagata aacacataaa tgttacaaga tattacgaaa cgattgtggg
    33361 gtgattaatt ggcagagttt tggtcaaaca atgatagagg ttaccgcatc aaacttacga
    33421 ttgatcaagt atcccaaaat acattagcaa acagtagcca agtgagggtt aaacttgatt
    33481 tgctaaatac aacaacaact tttactcaat atagttgttc tgcatatgtt gacttaaacg
    33541 gtcagcggat agactggtca gactcaccat cagtacttag atataactca acaatttctc
    33601 tgatcgatag aacaataaca gttaatcata atgctgatgg tactaaatca tttggattta
    33661 tcgctagctt tagcggctct ggtggatggt ctccgggtac tttgactgtt ggtagtggta
    33721 cttttacact tactaccatc ccacgctcaa gctccgttgt tgtttcttct ggtactattg
    33781 gcagtgccat cactatcaac atcaatagac aaagctctag ttttaagcac aacttgagat
    33841 accagtgggg taataaaaca ggtactattg caagcgatgt ggatacttcc gccgtttgga
    33901 ctatccctct tgattttgct agtgacatcc caaactcaac aagtggtagc ggcactatct
    33961 atgtagatac ctacaatgac tcaacgctaa ctggtactca acaagtgcca tttaccgtaa
    34021 ctgtaccaga cagtatgaag ccaacattat caagtattag cttgagtgat gctcataccg
    34081 ttgcaggcaa cgtagtatca agtgcggatt attttatcca agtatactct gacattagag
    34141 tcaattttga atcggcaagt ggctcttatg gttcgacgat taaaggttat tacgccgaga
    34201 ttgtcggtaa aggtcagtct actgagcaaa atggcggaac actggggaat atgctgtatg
    34261 acggacagat taccatcaga gcaaaggtta ttgatagtcg aggtcgtgaa tcgcaacccg
    34321 tggataaaac agtcacggtg ctcaagtact ttccgccagc tttgtcgttt gatgtcgcaa
    34381 ggtctggtta tggttctgac acgctaacag ttacaagacg agcgtctatc gctccgttaa
    34441 gtgttttcgg aacacaaaaa aataccatga cgcttagttt tagtgttgca gaattaggtt
    34501 ctagttattt ttctgctaat aacggctctg caagtggggc atgggcaaat gtttctagtt
    34561 tggtaaactc gtctgccaat ctttatggtg ctttctcgcc gacaaagtct tataccgtca
    34621 aaggtatctt gtctgacaaa tttagtcgca cagagtttac gtttgacgtc ggaacagaat
    34681 cagttgtgat gtcaatcgct aaaaatggca tcggattcca aaaaatttgg gaaaagggtg
    34741 ctattgacgc taaaggagat gcttatatta gcggtaagtt atttgtcaat aatacagagg
    34801 ttaaaccgtc gtttgacaag acagagattt taaacatggt ttatcctgtc ggagctattt
    34861 acatgagcac atcatcagcc aatccatcaa catttatcgg cggcacttgg caaagatatg
    34921 cacaaggtag gactattgtc ggggtctccg aaaacgagac ggaatttaat tacgttggta
    34981 aaactggtgg agccaagact catacattaa ccaacgaaga gatgccaagt cacagtcacg
    35041 gggataagac tattagctcg ggtggtagac ctatctcatc aaatgctgga tgggacaata
    35101 caaatgttgg tttatataaa tcaacagatt acaatcaaat aaacgctttt aacaagtctt
    35161 ctggaggtga tcaaccacat aacaacttac aaccatacat cacaacgtac atttggctga
    35221 gaacagctta gaggagaatt tatgttagtt atcacatcaa attacccaga acaaatgcct
    35281 gatggttccg tatctggtgc gaaggtgatg cttgacggga ttgatgatca cgctggttgg
    35341 catatcccgt tgacattacc caaagaatat ttagacaaac ctcaaagcga ggttatgaca
    35401 ctttgcgaaa agatgattta tcaacaatta aaaccacaaa aagcattaaa cgaaaagttt
    35461 gctaaactcg atgcaaccat tgaaaagggt gaaaatatgc ttaaatttgc gactggaatt
    35521 ttaaatcaaa ttatcgcagc aaaagaagag gaaacaacag atgatgaaac tgttgaaaaa
    35581 atggattaaa aggagatata tcatgatgat taattatttc gcaatgcaaa ttgagtttgg
    35641 ttggattact ttggaagatg tacctaaaaa atatcgtgac aaagtaaaac agcttgttga
    35701 atcagggaat atcggaacag aataacgaga ggccttatat gacgatagat gttacactat
    35761 ttgcgcaatg gtgtgtagcg cttactgcaa taatagtatt tttaaaatgg gtgtctgcac
    35821 ctgtcaaaca cgttttagac aataataaaa aggctatgga agccttggaa agtgctatcg
    35881 tcaaaatatc tgacgactta aaagacaaca attttaaatg gacagaatcc aaaaaccatc
    35941 gtgacagact acaaaaggtc caagatcagc acgaaatcag aatcggaatc gtagaagata
    36001 gacttattag tcatgacgag cagctaaaaa cgctctggaa agtaaaagag gaaaaaaaat
    36061 aatggaagaa ttaatacaag ttatcactgg ctcagctcta tcaattttga caatctttgc
    36121 aggtattgta gtcaagttaa tcaaagatta tttgcttaaa aaaggcggag aaaaagcggt
    36181 caaaatcgcc gaaattgtgg ctcgcaatgc cgtggaagca gttgagcaga ttgcttatga
    36241 caaagacatc aaaggtattg aaaaactgac agaagctaaa attgcggttc gtgacgaact
    36301 gtctaaacac aatgtctatt tgtcagacaa acaaatggaa gtctttattg aagcggctgt
    36361 taaacgcatg aacgacagtt ggaaaggtca ataatatggc aacagttagc gaagtaatta
    36421 gctattggcg tggattagct gatacaaatc aaggttatga tgccgacctt gcgtggggct
    36481 ggcaatgtgc tgatgtgact aatgggacaa ctactaactt ttttggagtg acgctttggg
    36541 ggaatgcgat tgacttgcta gacagtgcaa aggcgcaagg gttagaggtt atctatgacg
    36601 cccctggaat aaatcccaaa gctggtgatt tgtttgttat gtacacttat gctcatcctt
    36661 atggtcatac aggaattgtg attgctgata gtgatggtta tactatccaa acaattgagc
    36721 aaaatgtaga tggatactca gataataatg gagatggcat taatgaccag ttccaagttg
    36781 gcggaccagc acgatatgtc actcgtgcct tttcagacgg tgacggttat attgtcggtt
    36841 ggattagacc gccttatagc gatacctcat ctgaaaagca atcacaatca caagcgccat
    36901 caggattccg gaaattaaaa gacgaggtcg gaacatttga ggttatggtc ccagcgctaa
    36961 acgttcgccg tgaaccaagc ttaaatggcg agattgtagc ttgttaccaa tacggcatga
    37021 caggaactta tgattctgtc tatgttggcg atgggtatat ttgggtgtct tatgtcggtg
    37081 catctggcat gagaaattat atggctgttg gagacgctga tggcgattac aatgtcaatc
    37141 catattgtaa attttattaa aagggggtta tatgggatat aactcaacca accttaaaca
    37201 ggttgacggt ggcgatgtta tcaaacaagg tgatacatcg tcacttttta gttttaattt
    37261 gttggacgaa aacaacaacg ttattgattt aaatggcaaa caagcgacga tttactttac
    37321 acgtaatcgc aaaacctatc taaccaaaac aactgatgtt attgacaaca aagttgattt
    37381 tacgattaat aagattttgg agattgggac atactatatc gaagtgcact gcgatggcta
    37441 tgtctttccg tctgacgaca gcgtaacgct tgatgttaga cgttctgggc aaaaatatgt
    37501 cgttagcact gatttaatca cagacacaac tatccaaaaa ctatcagctg atattgagta
    37561 tttaaaatca aaagtgactc aaaatcagca tctatttgag caagtgtcac cacaaacaga
    37621 atggaccatt acacataatt tgattaagta tccatctgtg acaattgttg atagtgcagg
    37681 taatgaggtt tttggaagtg tcgagtacat tagcacaaca aaaatcatcg ttagattctc
    37741 agcgccattt gctggcaaag ccattttaaa ttaaaggaga ttacatgagt acatttttaa
    37801 caaatatcaa ccttaataaa aacgagttgc aaaatgcagt cgtacaaaat ttaggctcag
    37861 agccacaaga tccaaaaaca gggcaatttt attatgacag tgttgctaat aagctaaaaa
    37921 tttataacgg gacatcttgg gttgctttag acaaggaaac agcagaaagc attgttaacc
    37981 ttattaattc tggtgaatcc aaaatcgata aatcaaaagt cgatggactt gaagaagcaa
    38041 ttaatcgagc gtctatgact ggtcaagcta tcgcgaccgc tttaaacgaa gatactggtg
    38101 gcgttactgt aaaccaagat aaaattacag ggcttacaga taaactagct gaaattgcga
    38161 ctaacaaagc gtcagcgact cgggagtcac aagatgcttt gcaagaagcc aaggtgtatg
    38221 ctgaccaaaa agtagccgga cttgttgata gtgcatcaga agattacaac acgtttaaag
    38281 agctagaaac ttttattaaa caaaacgcga aaggtctcgc agcaatctca aatgtagcca
    38341 aaaaatttag taaaacgttt ggcgatgcac gagctaaaga atttacaatc acacacaacc
    38401 taaaaactcg tgatgttaac gtcactatcc gagagactaa cttcccttat gcaatcgtct
    38461 acgcagatat taaagtcaca gacgaaaata gcatcttaat cgcaacaggt gcagaagtac
    38521 caacgcaaaa tcagtatact gtgacaatta ctggatagga ggccgctatg agatatattg
    38581 gcgaatcaca actctcaaaa gaccttgtaa caaaagatta tgtagataac aaagtgacta
    38641 atctcgcgag taaggatgat attgttaatt taggtaaaat taaggactcg caaacaggtg
    38701 cgtttttgga agtcaaaata gtcccaaacg gtcaagtccc ttacgacacc actggcatga
    38761 ttgtgtttga acgctctgga ggtaagtaat gtcagtacaa gagataccag atgaaatttt
    38821 ttatcgatta atagagcaaa cagtagatac aaaactggtt tgggataagg acacacaaat
    38881 aggtagctat tatatatcta tacacgataa gtatagtttt gaatctggta gagatgttaa
    38941 catctataaa atcttatcta gcacacaggc tgatgtgtat aaagctaata agtataatta
    39001 tcaatcatca tcaaaaccag atactagcgt accacagccg aagccaccag agcaacctcc
    39061 gctcaaaaac aagtctttgt atcaatcaat cacgattgat ggactgccaa tagctcgcgt
    39121 tatctgtaac aatcatgtta tctggtctca atcagtagag caacaagaag tctacaacat
    39181 tacagcgtac gtagatgcta gcgtatctaa gctaaatgac tctgccatta ttgattacaa
    39241 tcgagatttt gcggcttacg gcgtaaattg gagtcgagtt gatagagtcg ccgttgaagt
    39301 cgacgataaa atagttgcta agctacaagc tcctgtctat gattttggtg ttagaggtgg
    39361 cacgacgatg tctgtcgaaa aatgggatta cccatcaaat acaatagaaa aatacaaaaa
    39421 tccaacattt aaaatttcgc agcattagga ggtaaagctc cgagataaga caaaaccg
//
LOCUS       DAUDWO010000016        39002 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.016, whole genome shotgun sequence.
ACCESSION   DAUDWO010000016 DAUDWO010000000
VERSION     DAUDWO010000016.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 39002)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39002)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39002
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.016"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            34..567
                     /locus_tag="VHC05_000787"
     CDS             34..567
                     /locus_tag="VHC05_000787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF177 domain-containing protein"
                     /protein_id="HEQ5402111.1"
                     /translation="MLAISEIRKHPDGLSFDRLCDVKSMLLERDQQIIDIKAVKAVGN
                     VRYDKGLYLLDYQLSYEVILPSSRSMVPVCLSEVQHIQELFIEATDLADKKELVEDNL
                     VLVLDKDAINLEESIVDNILLAIPLQVLTEEEKKSKELPAGQNWAVLTEEDYQCLKEE
                     KQKENNPFASLQGLFDE"
     gene            834..1520
                     /gene="covR"
                     /locus_tag="VHC05_000788"
                     /gene_synonym="csrR"
     CDS             834..1520
                     /gene="covR"
                     /locus_tag="VHC05_000788"
                     /gene_synonym="csrR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator CovR"
                     /protein_id="HEQ5402112.1"
                     /translation="MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALE
                     KEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMTARDSIMDVVAGLDRGADDYIVK
                     PFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
                     DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTV
                     RGMGYVIREK"
     gene            1526..3028
                     /gene="covS"
                     /locus_tag="VHC05_000789"
                     /gene_synonym="csrS"
     CDS             1526..3028
                     /gene="covS"
                     /locus_tag="VHC05_000789"
                     /gene_synonym="csrS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991036.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     CovS"
                     /protein_id="HEQ5402113.1"
                     /translation="MENQKQKQKKYKNSLPKRLSNIFFVLFFCIFSAFTLIAYSSTNY
                     FLLKKEKQSVFQAVNIVRVRLSEVDSNFTLENLAEVLYKNDKTHLRIDDRKGSRVIRS
                     ERDITNTLDANQDIYVYNIDKQMIFTTDNEESSPGLHGPIGRVYHDHIEDQYRGFSMT
                     QKVYSNRTGKFVGYVQVFHDLGNYYVIRARLLFWLLVVELFGTSLAYLIILITTRRFL
                     KPLHNLHEVMRNISENPNNLNLRSDISSGDEIEELSVIFDNMLDKLETHTKLQSRFIS
                     DVSHELRTPVAIIKGHIGLLQRWGKDDSDILEESLTATAHEADRMAIMINDMLDMIRV
                     QGSFEGHQNDMTVLEDSIETVVGNFRVLREDFIFTWQSENPKTIARIYKNHFEQALMI
                     LIDNAVKYSRKEKKIAINLSVTGKQEAIVRVQDKGEGISKEDIEHIFERFYRTDKSRN
                     RTSTQAGLGIGLSILKQIVDGYHLQMKVESELNEGSVFILHIPLAQSNES"
     gene            3243..3737
                     /gene="nrdR"
                     /locus_tag="VHC05_000790"
     CDS             3243..3737
                     /gene="nrdR"
                     /locus_tag="VHC05_000790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012657916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor NrdR"
                     /protein_id="HEQ5402114.1"
                     /translation="MRCPKCNYHKSSVVDSRQAEDGNTIRRRRECEQCHTRFTTFERV
                     EELPLLVIKKDGTREQFSRDKILNGVVQSAQKRPVSSTDIENVISRIEQEVRTTYENE
                     VSSTAIGNLVMDELAELDEITYVRFASVYKSFKDVDEIEELLQQITNRVRGKKKRLNN
                     DETN"
     gene            3721..4896
                     /locus_tag="VHC05_000791"
     CDS             3721..4896
                     /locus_tag="VHC05_000791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation and membrane attachment
                     family protein"
                     /protein_id="HEQ5402115.1"
                     /translation="MMKPIDTFTYLKRNKVTLDSVTLIQLYFPIIGSDAVSIYQYFIH
                     FFDDGLQRHKFSDILNHLQFGMKRFEDALAILTAMELVSVYQLSDTYLITLHQPLSRD
                     LFFQHPAYSRLLEQKIGEVAVSELQVTVPSQARNISKRFSDIFGVQGDLTNVPQKPQK
                     NFDLSSFQQLMVRDGLQFEDNQKDIISLYSIAEQYDMTWFDTYQIAKATAVNGKIRPE
                     RLLAKKNQSMTKPSKENFSQAEQIILREAKQDSALVFLEKIKKARRATITKDERILLQ
                     TLAKMNFLDDVINVMVLYTFNKTKSANLQKSYVLKMANDFAYQKVSTAEEAIVVLRAF
                     TDRQSRRQSKVKTSQSNVPKWSNPDYQETTSQEEQAKLDQFKQAALKRLENLGKGGD"
     gene            4897..5799
                     /gene="dnaI"
                     /locus_tag="VHC05_000792"
     CDS             4897..5799
                     /gene="dnaI"
                     /locus_tag="VHC05_000792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein DnaI"
                     /protein_id="HEQ5402116.1"
                     /translation="MEKIGETMAKLGQNTRVNSDQLIQTILADPEVASFISQHHLSQE
                     QINLSLSKFNQFLVERQKYQLKDPSYIAKGYQPILAMNEGYADVSYLETKELVEAQKQ
                     AAISERIQLVSLPKSYRHIHLSDIDVNNASRMEAFSAILDFVEQYPSAEQKGLYLYGD
                     MGIGKSYLLAAMAHELSEKKGVSTTLLHFPSFAIDVKNAISNGSVKEEIDAVKNVPVL
                     ILDDIGAEQATSWVRDEVLQVILQYRMLEELPTFFTSNYRFADLERKWATIKGSDETW
                     QAKRVMERVRYLAREFHLEGANRR"
     gene            5862..7172
                     /gene="der"
                     /locus_tag="VHC05_000793"
     CDS             5862..7172
                     /gene="der"
                     /locus_tag="VHC05_000793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="HEQ5402117.1"
                     /translation="MVLPTVAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYA
                     TGEWLNRQFSLIDTGGIDDVDAPFMEQIKHQAQIAMEEADVIVFVVSGKEGVTDADEY
                     VSKILYRTNTPVILAVNKVDNPEMRNDIYDFYSLGLGDPYPVSSVHGIGTGDVLDAIV
                     ENLPVEEAEENDDIIRFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFT
                     DADGQEFTMIDTAGMRKSGKIYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDK
                     RIAGFAHEAGKGMIIVVNKWDTLDKDNHTVAKWEADIRDQFQFLTYAPIIFVSALTKQ
                     RLNKLPDLIKRISESQNKRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVSVKP
                     PTFVVFVNEEELMHFSYLRFLENQIRAAFTFEGTPIHLIARKRK"
     gene            7379..10477
                     /locus_tag="VHC05_000794"
     CDS             7379..10477
                     /locus_tag="VHC05_000794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEQ5402118.1"
                     /translation="MMARLIPGRVRNEGIKLYEQGLVSFQDDNKGILQIEVETYQVQY
                     GADDEDITCQCDTFHMKHYCKHIAAVEYFLKNDQKGKLFLKQLTNQTKIKETTKKMTS
                     FGSLFLDSLAMNEDDSVKYRLSALGSRSHFSSDYWWSLKINRLPDDRSYVIRDIKGFL
                     QLIKKEGFYQIGKNYFEQLSWLQFDPSSQDLIEFLWRLASDTDKGDNENIFPNHARHL
                     RLPSGFFEEGIHYLTSLYDFTFEGPSQTYHHLFVRSLEAEAGLYEFKVEVHRKSIELQ
                     IAEKNVQYLFDNDYLLYQDTFYHLTLKQRKMVQAIRSLPIEADLAKHIHFDLDDHAKL
                     AASLSDFKQIGLVEAPKSFAIRDFEVTFQFDLLNRDEISCQLMFDYGNYQVSDKASLE
                     ALPFASHLKKEEKINRSLLAFGFSPQFYSKKRLTSAKELYTFFEETVPCFERLGNVAL
                     STAIQALQVKEMPKIAIKRNQGLLDISFDFSTIIENDIDQAVTALFQNNPYFVSQTGQ
                     LVVFDDETQKVSKSLQELRARQLKNGHLQLDGIRALQVSKLFEGMTSVHFSKELEELA
                     YHLQHPETFSIKPLPVKAQMRDYQRNGVQWLSMLNHYGFGGILADDMGLGKTLQTLAF
                     LASHLKSDSKVLILSPSSLIYNWFDECQKFTPQLDVVVSYGLKQTRDQIIEEGHQITI
                     TSYSSFRQDFETYQAFHYDYLILDEAQVIKNAQTKISHCLRAFNTANCFALSGTPIEN
                     KMLEIWSIFQIVLPGLLPTKKEFLKLTAEQVSRYIKPFVMRRKKEDVLPELPDLIETN
                     YSNEMTDEQKAIYLAQLRQMQDQIRNSSDVDISRQKIEILSGITRLRQICDTPSLFMN
                     YQGKSGKLDSLRILLTQIKENGHRALIFSQFRGMLDLAKQEMTALGLTSYQMTGSTPA
                     NERQEMTRAFNNGSKDAFLISLKAGGVGINLTGADTVILIDLWWNPAVEMQAISRAYR
                     IGQKENVEVYRLITRGTIEEKILELQESKRNLVTTVLDGNESRASMSIEEIKEILGLN
                     TH"
     gene            10719..11321
                     /locus_tag="VHC05_000795"
     CDS             10719..11321
                     /locus_tag="VHC05_000795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402119.1"
                     /translation="MVKNQFPLVADGIAISDPAKQMALYENEDLITNIRGYYQDKEYD
                     DIAGNEELTAKATSRQAPSSKRFCSNDEKHHYVKEARQKAKQDLKEKRQAYLAKEMAY
                     VPKQVSKKQQPADSSPSQKQATTEMSRFTKKLHQDNYILAELPKEYKEPKNLPQQGTT
                     KKNNYDFLKSSQIYNNKEMRQQREKTIAQELNLSRFEDLP"
     gene            11361..12689
                     /locus_tag="VHC05_000796"
     CDS             11361..12689
                     /locus_tag="VHC05_000796"
                     /EC_number="6.3.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018363778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="HEQ5402120.1"
                     /translation="MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGL
                     EQAGITILPFSEDNITPDMELIVGNAFRENNKEVAYALRHQIPFKRYHDFLGDFMKSF
                     ISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFM
                     PYHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAP
                     IYYYGFEEGNDFIAYDITRTTNGSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANL
                     FVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTEIVATIDAARQKYPS
                     KEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVKVEDLAAKI
                     IKPSQVVTVENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ"
     gene            12735..13217
                     /locus_tag="VHC05_000797"
     CDS             12735..13217
                     /locus_tag="VHC05_000797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEQ5402121.1"
                     /translation="MLIRQVQGSDLEVIATIESDNFSPQEATTRAVLEERIRLIPDTF
                     LVALIDQEIVGYIEGPVVTTPILEDSLFHGVTKNPKTGGYIAITSLSIAKHFQQQGVG
                     TALLAALKDLVVAQQRTGLILTCHDYLISYYEMNGFINQGISESQHGGTLWYQMIWKL
                     "
     gene            13329..14903
                     /gene="mltG"
                     /locus_tag="VHC05_000798"
     CDS             13329..14903
                     /gene="mltG"
                     /locus_tag="VHC05_000798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endolytic transglycosylase MltG"
                     /protein_id="HEQ5402122.1"
                     /translation="MALTDFKDKDQQDQQRSFKEQILAELEKANQIRKEKEEELFQKE
                     LEAKEAARRTAQLYAEYKRQDTFQKESIAHNNKTAKHFQAIKDAVMTSEAIKPTLLSE
                     KENSSLKTTSKRVVQANELQETASKESQVPLTIEKGHSVRRKLSKRQQTERAAKKIST
                     VLISSIIITLLAVTLAGAGYVYSALNPVDKNSDAFVQVEIPSGSGNKLIGQILQKKGL
                     IKNSTVFSFYTKFKNFTNFQSGYYNLQKSMSLEEIASALQEGGTAEPTKPSLGKILIP
                     EGYTIKQIAKAVEHNSKGKTKKAKTPFNEKDFLDLVTDEAFIQDMVKRYPKLLATIPT
                     KEKAIYRLEGYLFPATYNYYKETTMRELVEDMLAAMDATLVPYYDKIAASGKTVNEVL
                     TLASLVEKEGSTDDDRRQIASVFYNRLNSGMALQSNIAILYAMGKLGEKTTLAEDATI
                     DTTINSPYNIYTNTGLMPGPVASSGVSAIEATLNPASTDYLYFVANVHTGEVYYAKTF
                     EEHSANVEKYVNSQIQ"
     gene            14976..15458
                     /gene="greA"
                     /locus_tag="VHC05_000799"
     CDS             14976..15458
                     /gene="greA"
                     /locus_tag="VHC05_000799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016481121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription elongation factor GreA"
                     /protein_id="HEQ5402123.1"
                     /translation="MAEKTYPMTLTEKEQLEKELEELKLVRRPEIVERIKIARSYGDL
                     SENSEYDAAKDEQAFVEGQISTLETKIRYAEIIDSDAVAKDEVAIGKTVIVHEVGTTD
                     KDTYHIVGAAGADIFSGKISNESPIAQALIGKKTGDKVRIESPAATYDVEIISVEKTS
                     "
     gene            complement(16082..17005)
                     /gene="yidC"
                     /locus_tag="VHC05_000800"
     CDS             complement(16082..17005)
                     /gene="yidC"
                     /locus_tag="VHC05_000800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HEQ5402124.1"
                     /translation="MRLTLNRILFSGLALSILFTLTGCVGRDAHGNPKGMIWEFLGKP
                     MSYFIDYFANNAGLGYGLAIIIVTIIVRTLILPLGLYQSWKASYQSEKMTFLKPVFEP
                     INKRIKQASSQEEKMAAQTELMAAQRAHGINPLGGIGCLPLLIQMPFFSAMYFAAQYT
                     KGVSTSTFMGIDLGSRSLVLTAIIAALYFFQSWLSMMAVSEEQREQMKTMMYTMPIMM
                     IFMSFSLPAGVGLYWLVGGFFSIIQQLITTYLLKPRLHKQIKEEYAKTPPKAYQSTSS
                     RKDVTPSQNMEQANLPKKIKSNRNAGKQRKR"
     gene            complement(17087..17365)
                     /locus_tag="VHC05_000801"
     CDS             complement(17087..17365)
                     /locus_tag="VHC05_000801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acylphosphatase"
                     /protein_id="HEQ5402125.1"
                     /translation="MQKVRLIVSGRVQGVGFRYATHTLALDIGDIYGRVWNNNDGTVE
                     ILAQSKDSDKIATFIQEVRKGPSKWAKVTYVDVTMANFEDFQDFQIGN"
     gene            17626..18363
                     /locus_tag="VHC05_000802"
     CDS             17626..18363
                     /locus_tag="VHC05_000802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA methyltransferase"
                     /protein_id="HEQ5402126.1"
                     /translation="MVITSKANQLIKQTKKLLQKKHRKQSYLIEGWHLFEEAQKSGQV
                     FRHIFVLEEMVERLAGEQELVIVSPQVLKELTDSPSPQGIVAEVEIPKLAFPSDYKGK
                     YLVLEDVQDPGNLGTIIRTADAARFDGVFLSEKSADIYNQKTLRSMQGSHFHLPIWRT
                     DVYQLCRELQEYKTPILATTLSKKSVDYKSLTHHERLALVLGNEGQGISAEMAALADQ
                     LVHITMPGQAESLNVAVAAGILIFSLI"
     gene            18402..18902
                     /locus_tag="VHC05_000803"
     CDS             18402..18902
                     /locus_tag="VHC05_000803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HEQ5402127.1"
                     /translation="MHYTEDKEYMEHVGHLIAHPRFQKLSHIVQHQHSTRLEHSINVS
                     YSSYKLAKRFGWDAKSTARGGLLHDFFYYDWRVTKFNKGHAWVHPRIAVRNAKKLTEL
                     NKKEEDIILKHMWGATIAFPRYKESYIVTMVDKYWAVKEAVTPLRQKWSNRRFLRRKT
                     LQSHNR"
     gene            18917..19606
                     /locus_tag="VHC05_000804"
     CDS             18917..19606
                     /locus_tag="VHC05_000804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="HEQ5402128.1"
                     /translation="MNDHVIYTQSDVGLNQFFAKIYSLVGMGVGLSAFVSYLMLYPFR
                     ENLISILVNQPMIYYGAAIIELILVFIASGAARKNTPAALPIFLIYSALNGFTLSFII
                     VAYAQTTVFQAFLSSAAVFFAMSIIGVKTKRDMSGLRKAMFAALIGVVVASLINLFIG
                     SGMMSYVISVISVLIFSGLIASDNQMIKRVYQATNGQVGDGWAVAMALSLYLDFINLF
                     ISLLRIFGRND"
     gene            19784..20026
                     /locus_tag="VHC05_000805"
     CDS             19784..20026
                     /locus_tag="VHC05_000805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YneF family protein"
                     /protein_id="HEQ5402129.1"
                     /translation="MSTAIWILLLIVALGVGVFGGIFIARKQIEKEIGEHPRLTPEAI
                     REMMSQMGQKPSEAKIQQTYRNIIKQSKAAVSKGKK"
     gene            20204..20998
                     /gene="racE"
                     /locus_tag="VHC05_000806"
     CDS             20204..20998
                     /gene="racE"
                     /locus_tag="VHC05_000806"
                     /EC_number="5.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate racemase"
                     /protein_id="HEQ5402130.1"
                     /translation="MDTRPIGFLDSGVGGLTVVCELIRQLPHEKIVYIGDSARAPYGP
                     RPKKQIKEYTWELVNFLLTQNVKMIVFACNTATAVAWEEVKAALDIPVLGVVLPGASA
                     AIKSTTKGQVGVIGTPMTVASDIYRKKIQLLAPSVQVRSLACPKFVPIVESNEMCSSI
                     AKKIVYDSLAPLVGKIDTLVLGCTHYPLLRPIIQNVMGPSVKLIDSGAECVRDISVLL
                     NYFDINGNYHQKAVEHRFFTTANSEIFQEIASIWLKQKINVEHVTL"
     gene            20995..21981
                     /locus_tag="VHC05_000807"
     CDS             20995..21981
                     /locus_tag="VHC05_000807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-triphosphate diphosphatase"
                     /protein_id="HEQ5402131.1"
                     /translation="MSEKIYEYKDENNWFIGKMTGHNLISGWGVKHTTIKKIDDLLDG
                     IAATLDWENPKGYDVSVVRYQSPLSLITFIIDMINQETQRKIKVTPHAGTILLMENAK
                     LLAVYLPEGGVSTATFFATSEQGFGDIILIATRNEGKTKEFRNLFGQLGYRVENLNDY
                     PELPEVAETGTTFEENARLKAETISRLTGKMVLADDSGLKVDALGGLPGVWSARFSGP
                     DATDAKNNAKLLHELAMVFDQKKRSAQFHTTLVVAAPNKDSLVVEAEWPGYIATQPKG
                     ENGFGYDPVFIVGETGRHAAELEADQKNQLSHRGQAVRKLMEVFPAWQAKQS"
     gene            21960..22481
                     /locus_tag="VHC05_000808"
     CDS             21960..22481
                     /locus_tag="VHC05_000808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HEQ5402132.1"
                     /translation="MASKTIIVMSDSHGDRDIVQAIKDKYLGQVDAIFHNGDSELNSS
                     DPIWAGIYVVGGNCDYDTGYPDRLVTQLGTVTIAQTHGHLYHINFTWDKLDYFAQEVA
                     ADICLYGHLHRPAAWQVGQTLFMNPGSVTQPRGEINEKLYARVELTDTQIKVDYFTRD
                     HKLYPSLSKEFKR"
     gene            22478..22939
                     /locus_tag="VHC05_000809"
     CDS             22478..22939
                     /locus_tag="VHC05_000809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEQ5402133.1"
                     /translation="MIAKEFETFLMSHLDNYLIPEQDLAIFIDTHNADHVMLLLVSNG
                     FSRVPVITREKKYVGTISISDIMMYQSKRQLTDWEMSQTDIGEMVNTKIETISITSSL
                     TEIMHKLIDYPFLPVVDRANRFVGIITRKSILKAVNSLLHDFTDDYTIIKK"
     gene            22936..23682
                     /gene="xerD"
                     /locus_tag="VHC05_000810"
     CDS             22936..23682
                     /gene="xerD"
                     /locus_tag="VHC05_000810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific tyrosine recombinase XerD"
                     /protein_id="HEQ5402134.1"
                     /translation="MKSYIEPFIASKALSQNSQKAYRYDLQQFCQLVGERVNQDKLLL
                     YQNSIANLSLSAKKRKLSTANQFLYYLYQIKYLNSYFRLTDTMKVMRTEKQQAAIINT
                     DIFYQKTPFVWGQLISLLILELGLTPSEVAGIEVANLDLNFQMLTLKTKKGVRVLPLS
                     QILIPFLEQQLIGKEVYLFEHRGIPFSRQWFFNHLKTFVRSIGYEGLTAQKLREQFIL
                     KEKLAGKSIIELSDILGLKSPVTLEKYYKS"
     gene            23682..24386
                     /locus_tag="VHC05_000811"
     CDS             23682..24386
                     /locus_tag="VHC05_000811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein A"
                     /protein_id="HEQ5402135.1"
                     /translation="MDIKLKDFEGPLDLLLHLVSQYKVDIYEVPIVEVIEQYLNYIET
                     LQVMKLEVAGDYMLMASQLMLIKSRRLLPKVVEHIEEEDLEQDLLEKIEEYSRFKAVS
                     QALAKQHDQRAKWYSKPKQELIFEDAILQEDKTVMDLFLAFSNIMAAKRAVLKNNHTV
                     IERDDYKIEDMMASIKQRLEKENVISLSAIFEECQTLNEVISIFLASLELIKLHVVFV
                     EQLSNFGAIILRKEKK"
     gene            24383..24934
                     /locus_tag="VHC05_000812"
     CDS             24383..24934
                     /locus_tag="VHC05_000812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein B"
                     /protein_id="HEQ5402136.1"
                     /translation="MTYLSQIEALLFVAGEEGLSLRHLASMLSLTPTALQQQLEKLSQ
                     KYEKDQHSSLCLIETANTYRLVTKEGFAELLRAYAKTPMNQSLSRASLEVLSIVAYKQ
                     PITRIEIDDIRGVNSSGALSKLLAFDLIREAGKKDVVGRPHLYATTDYFLDYMGINHL
                     DELIEVSAVEPADEEIALFRTQD"
     gene            25055..25777
                     /locus_tag="VHC05_000813"
     CDS             25055..25777
                     /locus_tag="VHC05_000813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEQ5402137.1"
                     /translation="MRINKYIAHAGIASRRKAEELIKQGLVTLNGQVITDLATTVKSG
                     DVVEIEGSPIYNEEKVYYLLNKPRGAISSVSDDKGRKTVLDLLPQVKERIYPVGRLDW
                     DTSGVLILTNDGDFTDTMIHPRNEIDKVYLARVKGIATKENLRPLTRGIVIDGKKTKP
                     ARYNIVRVEADKNRSIVELTIHEGRNHQVKKMFESVGLLVDKLSRTRFGTVDLKGLRP
                     GEARRLNKKEISQLHNLANTKK"
     gene            25774..26037
                     /gene="yidD"
                     /locus_tag="VHC05_000814"
     CDS             25774..26037
                     /gene="yidD"
                     /locus_tag="VHC05_000814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="HEQ5402138.1"
                     /translation="MMKKLLIVSVKAYQKYISPLSPPSCRYKPTCSAYMLTAIEKHGT
                     KGILMGIARILRCHPFVAGGVDPVPEDFSLMRNKNTSKNAEKA"
     gene            26215..26763
                     /locus_tag="VHC05_000815"
     CDS             26215..26763
                     /locus_tag="VHC05_000815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (uridine(34)/cytosine(34)/5-
                     carboxymethylaminomethyluridine(34)-2'-O)-
                     methyltransferase TrmL"
                     /protein_id="HEQ5402139.1"
                     /translation="MTTKELINKNDKVKKARNHIVLFQPQIPQNTGNIARTCAATNAP
                     LHIIKPMGFPIDDRKMKRAGLDYWDKLELHFYDHLEQFINQCHGQLHLISKFAVNNYS
                     QATYADGDSHYFLFGREDTGLPEDFMREHAEKALRIPMNDEHVRSLNVSNTVCMVIYE
                     ALRQQGFQGLELKHTYEHDKLK"
     regulatory      26872..26995
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            27074..27637
                     /locus_tag="VHC05_000816"
     CDS             27074..27637
                     /locus_tag="VHC05_000816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEQ5402140.1"
                     /translation="MSKTHKMIMIGILSAISFLLMLVSFAIIPGAAFLKIEFSIIPVL
                     FGLMIMDLKSAYLILLLRSLLKLFLNNRGVNDFIGLPMNIIAIALFVTAFALVWNRQK
                     TLSQYVFASLLGTGLLTFGMVVLNYTFAIPLYAIFANIDIRAYIGVTKYMMTMVIPFN
                     LVEGLIFAITFYFVYIASKPILERYLH"
     gene            27639..28292
                     /locus_tag="VHC05_000817"
     CDS             27639..28292
                     /locus_tag="VHC05_000817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HEQ5402141.1"
                     /translation="MMTNKQTHFLIASFALLIFVIIGYTVKFFPERLALLDNTIQAEI
                     RGNLPIVLTQFFRGVTVFGNVMTQILLVIVSVLVLFFMKWKIEALFILSNGAIAAFLI
                     TTLKLFYQRPRPAIEHLVYAGGYSFPSGHAMGSMLIFGSLLIICYQRLHSKLLQFVTS
                     MIFIILILVIGLSRIYLGVHYPSDILAGFVLGFGILQFIYPFYKQKRFEWRFLLKQD"
     gene            28585..29505
                     /locus_tag="VHC05_000818"
     CDS             28585..29505
                     /locus_tag="VHC05_000818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407327.1"
                     /note="This family includes YhcC from E. coli K-12, an
                     uncharacterized radical SAM protein; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01212 family radical SAM protein"
                     /protein_id="HEQ5402142.1"
                     /translation="MKKRYQTLNEHYRQLFGAKMFKVPIDAGFDCPNRDGTVAHGGCT
                     FCTVSGSGDAIVAPDAPIKEQFYKEIDFMHRKWPDVNRYLVYFQNFTNTHDTVDVIRD
                     RYEQAINEPGVVGINIGTRPDCLPDDTIAYLAELSERMHVTVELGLQTTYEETSRLIN
                     RAHSYDLYKDTVRRLRHYPNINIVSHLINGLPKETHDMMLENVRRCVTDNDIQGIKLH
                     LLHLMTNTRMQRDYHEGRLKLLSQKDYVSIICDQLEIIPKHIVIHRITGDAPRDMLIG
                     PMWSLNKWEVLNAIDKEMERRGSFQGCKVD"
     gene            29544..30098
                     /locus_tag="VHC05_000819"
     CDS             29544..30098
                     /locus_tag="VHC05_000819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEQ5402143.1"
                     /translation="MLKRPIHLSHDFLAEVVDKSSVVVDATMGNGNDTAFLAQLAKKV
                     YAFDVQEQAIRKTSERLAQLGLLNAELILAGHEAVDQYVTEPVRAAIFNLGYLPSADK
                     SIITLPNTTLQALSKLLTLLMVGGRIAIMVYYGHDGGSLEKDALLDFVKQLDQRKVSA
                     MLYQPLNQVNTPPFLIMLEKLADV"
     gene            30231..31565
                     /locus_tag="VHC05_000820"
     CDS             30231..31565
                     /locus_tag="VHC05_000820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
                     /protein_id="HEQ5402144.1"
                     /translation="MEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQK
                     AADGDKKYARLLRVLEEPNHFLSTIQVGITFISLLSGASLSASLGKVISGWLGNSATA
                     RTAGTIISLVFLTYVSIVLGELYPKRIAMNLKDKLAIVSAPIIIGLGRLVSPFVWLLS
                     ASTNLLSRLTPMTFDDADEQMTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMARE
                     VMVPRTDAFMIDINDDPLENIQEILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQ
                     GFDQINMRKMLQEPLFVPETIFVDDLLRQLRNTQNQMAILLDEYGGVAGLVTLEDLLE
                     EIVGEIDDETDKAEQFVHEIGDNTYIVVGTMTLNEFNDYFDTELESDDVDTIAGFYLT
                     GIGTIPSQEQKEAYEIDNKDKHLVLINDKVKDGRITKLKLILSNIEQIIEED"
     gene            31643..32434
                     /gene="pflA"
                     /locus_tag="VHC05_000821"
     CDS             31643..32434
                     /gene="pflA"
                     /locus_tag="VHC05_000821"
                     /EC_number="1.97.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate formate lyase-activating protein"
                     /protein_id="HEQ5402145.1"
                     /translation="MTEKDYGQVTGMVHSTESFGSVDGPGIRFIIFLQGCKLRCQYCH
                     NPDTWEMETNNSKIRTVNDVLKEALQYKHFWGKKGGITVSGGEAMLQIDFITALFIEA
                     KKLGIHTTLDTCGFTYRPTPEYHQVLDNLLAVTDLILLDLKEIDEKQHKIVTRQPNKN
                     ILQFARYLSDKQIPVWIRHVLVPGLTDIDDHLTRLGEFVKTLKNVDKFEVLPYHTMGE
                     FKWRELGIPYQLEGVKPPSKERVQNAKNLMQTESYTEYMNRIHQS"
     gene            32565..33500
                     /locus_tag="VHC05_000822"
     CDS             32565..33500
                     /locus_tag="VHC05_000822"
                     /EC_number="3.6.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese-dependent inorganic pyrophosphatase"
                     /protein_id="HEQ5402146.1"
                     /translation="MSKILVFGHQNPDTDAIASSYAFDYLSQKAFGLDTEVVALGTPN
                     EETAFALDYFGVEAPRVVESAKAQGSEQVILTDHNEFQQSIADIREVEVYGVVDHHRV
                     ANFETANPLYMRVEPVGSASSIVYRMFKENGIEVPKAIAGMLLSGLISDTLLLKSPTT
                     HVSDHLVAEELAELAEVNLEDYGMALLKAGTNLASKSEVELIGIDAKTFELNGNAVRV
                     AQVNTVDIAEVLERQEAIEAAIKDAMAAEGYSDFVLMITDIVNSNSEILAIGANMDKV
                     EAAFNFTLDNNHAFLAGAVSRKKQVVPQLTESFGA"
     gene            33576..34229
                     /locus_tag="VHC05_000823"
     CDS             33576..34229
                     /locus_tag="VHC05_000823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1803 domain-containing protein"
                     /protein_id="HEQ5402147.1"
                     /translation="MITIFHSDKLTRQPFFQDLINYLDQHDHVILREIKKAFPNVTGI
                     DKAIESYVQAGYICRENKRYGINLPLVSSDQQLALDTMLFVDTCSAMYENILAVVFET
                     HLTNQTNHVMIKEKTNITRDDLTLANYFYRLKRGEKPSAEQMDLYDLLGDVNQEYALK
                     YMTTFLLKFTRKDLVMQKRPDIFVEALVTLGYLKQVEPTTYQLLMTLDKESLTFIAP"
     gene            complement(34274..35311)
                     /locus_tag="VHC05_000824"
     CDS             complement(34274..35311)
                     /locus_tag="VHC05_000824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEQ5402148.1"
                     /translation="MLFMVNKKRRPLLKSQRHLLRLYTSLILLLVSLMGLALSLGESH
                     LSFLDFVHVFLGKSSHAISFIVINIRLPRILAACLGGGSLALSGLLLQRLTRNPLADS
                     GVLGITIGAGISLAIVVSFSFFEQAHISHYLPLFAMLGAVVTTFSVYWLSLTKQGQID
                     PTRLILTGVAVTTMLSSLMVALVGHINHYKVDLVINWLSGQLIGDDWPTLSVIAPLLL
                     CFWLLTYSQAHFLNIMGLADNTAIGLGLPLNRKRRLILVLAAGLGALSVLLVGNISFI
                     GLIAGHFSTYLVGSNHKLTIPISILIGMILLLVADTVGRVYLVGSNIQTGILVSLIGA
                     PYFLYLMAKTK"
     gene            complement(35272..36324)
                     /locus_tag="VHC05_000825"
     CDS             complement(35272..36324)
                     /locus_tag="VHC05_000825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEQ5402149.1"
                     /translation="MKTKHPFLCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYC
                     HLRFGAVALSHQDLNSILFGKQNGHKANVLLAIRLPRLFGATLTGSALAVSGTIMQAI
                     TRNPIAEPGLLGINAGAGLALVLAYAFVPHLHYSLIILLSLLGSSLAATLVFGLSYQS
                     GKGYHQLRLVLAGAMVSILLSALGQGITNYYHLANAVIGWQAGGLVGVNWQMIGYIAP
                     LIILSLCLAQLLSYHLTVLSLSESQAKALGQKTNLISAVFMILVLILSSAAVAIAGSI
                     SFIGLVIPHLMKHFTPHHYRYLLPLCAVSGASFMVWVDIACRNLNPPYETPLGALVSL
                     IGFPCFLWLIRRGGRY"
     gene            complement(36314..37246)
                     /locus_tag="VHC05_000826"
     CDS             complement(36314..37246)
                     /locus_tag="VHC05_000826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-hydroxamate ABC transporter
                     substrate-binding protein"
                     /protein_id="HEQ5402150.1"
                     /translation="MKKLTLLLTLCLTTTTLIACGNQATNHSNTASKSLSPMPQIAGV
                     TYYGDIPKQPKRVVSLASTYTGYLKKLDMNLVGVTSYDKKNPILAKTVKKAKQVAATD
                     LEAITTLKPDLIVVGSTEENIKQLAEIAPVISIEYRKRDYLQVLSDFGHIFNKEGKAK
                     KWLKDWKTKTAAYEKEVKAVTGDKATFTIMGLYEKDVYLFGKDWGRGGEVIHQAFHYD
                     APEKVKTEVFKQGYLSLSQEVLPDYIGDYVVVAAEDDKTGSALYESKLWQSIPAVKKH
                     HVIKVNANVFYFTDPLSLEYQLETLREAILSSEN"
     gene            complement(37272..38054)
                     /locus_tag="VHC05_000827"
     CDS             complement(37272..38054)
                     /locus_tag="VHC05_000827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402151.1"
                     /translation="MTTISAEDLTIAYGQRTIIDKLSFYIPEGKITTIIGANGCGKSS
                     LLKALTRLLPPKQGIVYLNGQNIATLETKEVAKKLALLPQVQEATNGITVYELVSYGR
                     FPHQSYFGNLSPADKKAIHWAMQATNVMAYADQPVDALSGGQRQRVWLAMALAQGTDT
                     IFLDEPTTYLDLNHQLEILELVKSLNKDAGKTIVMVLHDLNLSARYSDHLIAMKHGKI
                     HYTGTIADVMTSPIIQDIFLIKPVLVDDPIHNCPIVLTYQLQ"
     gene            complement(38147..>39002)
                     /locus_tag="VHC05_000828"
     CDS             complement(38147..>39002)
                     /locus_tag="VHC05_000828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEQ5402152.1"
                     /translation="WFHKGDHKEVFAYSAQVACDKYGWALAYSVEAGNIHDSQAFPAL
                     FAKLEPLKPQFIIADSGYNIPSIAKFLIDKEITPVLPYTRPRGKKDLLRPNEFIYDEH
                     FDCVICPEHQALTYRTTTREGYREYKSDPAICANCPLLSVCTTSKNHQKVVTRHIWKD
                     YLEQCEDIRHQRGMKELYQHRKETIERLFGTAKEYHNLRYTREKGKSKMEDKVGLTLA
                     CLNLKKLVKRMAGEPFYFVQMRWFKHGNSHFYLKTLKKTSTKSMFVFNLGFVKPFFYA
                     IIVKILRK"
BASE COUNT        12503 a         6724 c         8020 g        11755 t
ORIGIN      
        1 aaaaataaat gagagtttta ttaggagaag atgatgttag ctatttccga aatcagaaaa
       61 cacccagacg gtctctcgtt tgatcgttta tgtgatgtca aaagtatgtt acttgagcgt
      121 gaccaacaga ttattgacat aaaggcagtt aaagctgtcg gtaatgttcg ctatgataag
      181 gggctttatc tgttagatta tcaattgagt tacgaagtga tattaccgtc tagccgttct
      241 atggttccgg tctgtttaag tgaagtccaa cacattcaag aattatttat agaggcgaca
      301 gatttagctg ataagaaaga gttggttgaa gacaatctgg tattagtttt agacaaagac
      361 gctattaacc tcgaagaaag tattgtggat aatatcttac ttgctattcc gctacaggtc
      421 ttgacagagg aagaaaagaa atcaaaagag ttgccagcag gtcaaaattg ggcagttttg
      481 acagaagaag actaccagtg tctaaaagaa gaaaaacaaa aagaaaataa tccttttgct
      541 agcttgcaag ggttgtttga tgaataaaac tgaatattaa agatgtctgt aatttttatt
      601 tgaaaaaaca gctattcttt gatatactct ttagagaata tggttactta tctaaagtag
      661 aaggtatttt gaccatagag ggcaaagaag gtaatgacta ttagatgctt catattttat
      721 tcgctagaag actatttgac cattagaact gaaatagtct aggatatgag atggatttca
      781 tagttttctt tctgggagaa aaagatagat taagaggata agggttggta taaatgacaa
      841 agaaaatttt aattattgaa gatgaaaaga atctggctag attcgtttct cttgagctgc
      901 aacatgaggg ttatgaagtc attgttgagg tcaatggtcg cgaagggtta gaaactgctt
      961 tggaaaaaga gtttgattta atcctgcttg acttaatgtt accagagatg gatggttttg
     1021 aagtgacccg tcgtttgcaa accgaaaaaa caacatatat catgatgatg actgcgcgtg
     1081 attctattat ggatgtggtt gcaggtttag accgcggtgc agacgactat attgttaaac
     1141 cgtttgccat tgaagaacta cttgcccgta ttcgtgctat tttccgccgt caagacattg
     1201 aatctgagaa gaaagtgcct agtcaaggca tttatcgaga tctagtttta aatccacaaa
     1261 accgttcagt taatcgtggc gacgatgaga tttctctcac taaacgtgaa tatgatttgc
     1321 ttaatatttt gatgactaac atgaatcgtg tcatgacacg tgaagaatta ttgtcaaatg
     1381 tttggaaata tgatgaagcc gttgagacta atgttgtaga tgtctatatt cgttatctcc
     1441 gcggcaaaat tgacattcca ggcaaggaat cttatatcca aacagtgcgt ggcatgggat
     1501 acgttattcg tgagaaataa gtcatatgga aaatcagaaa caaaaacaga agaaatataa
     1561 aaactcgtta ccaaaacgac tatctaatat cttttttgtt ctttttttct gcattttctc
     1621 tgcctttaca ctgattgcct atagttcaac aaactatttc ttattgaaga aagaaaagca
     1681 gtcagttttt caagctgtaa atattgttag agttcgtctt tctgaggtgg actctaattt
     1741 tacattagag aacttagcag aagttttgta caaaaacgat aaaacacatc tgagaattga
     1801 tgacagaaag ggcagtcgag tcattaggag tgagcgcgat atcacaaata ctctagatgc
     1861 gaatcaagat atttatgtct ataacattga taaacagatg atttttacca cagataatga
     1921 agaatcatct cctggcttgc atggtcctat cggtcgggtg tatcacgacc atatcgaaga
     1981 tcagtatcgt gggttttcca tgacacaaaa ggtatattct aatcggactg gaaaatttgt
     2041 gggctatgtt caagtctttc atgatttagg caattattat gtcattagag caagactgct
     2101 gttttggcta ctagttgttg agttatttgg cacaagctta gcctatttaa tcatcttaat
     2161 tactacgcgg cgctttttga agcctttaca caatttacat gaagtaatgc gtaatatctc
     2221 tgaaaatcct aataatttaa acctgcgctc agatatttcg tcaggagatg aaatcgaaga
     2281 attgtctgtt atctttgaca atatgttaga caaattggag acacatacta agttgcaatc
     2341 acgttttatt agtgatgtca gccatgaatt acgaacaccg gttgcgatta ttaaagggca
     2401 tattggtctc ttacaacgtt ggggtaaaga tgacagtgat attcttgaag aaagtttgac
     2461 agcaacagcg catgaggctg accgtatggc aatcatgatt aatgatatgt tagacatgat
     2521 tcgcgtacaa ggctcatttg agggacatca aaatgatatg acagttttgg aagattctat
     2581 tgaaactgtt gttggtaatt ttagagtttt aagagaagat tttatcttta catggcagtc
     2641 agaaaatcca aaaacgatag cccgtattta taaaaatcat tttgagcagg ctttgatgat
     2701 tcttattgac aatgctgtga agtattcccg taaagaaaag aaaatcgcga ttaacctttc
     2761 agtgactggc aaacaagaag ctattgttag agttcaagat aaaggcgaag gaatttctaa
     2821 agaagatatt gaacatatct ttgaacgctt ttatagaacg gataaatcac gtaatcgaac
     2881 aagtactcag gctggattag ggattggctt gtctattctc aagcaaattg tagatgggta
     2941 tcatttacag atgaaggttg aaagtgaatt aaatgaaggt tcagtgttta tcttacatat
     3001 tcctttggcc cagtctaacg agagttagag tagcttaagg cattgttaat gtgacaggta
     3061 tagtatgtaa tcattagata atagtagcag gcttttgcca caactggtta gaagctgatg
     3121 ctattttttt agcaatgatg gatgatatga aagaaatact gtcaatcgcg atgccttttg
     3181 ttatccttga gaatatggta aaatagtgta ttagattaat ttgatagaat tggggtgttt
     3241 gcgtgcgttg tccaaaatgt aattaccata aatcgagtgt tgttgacagt agacaggctg
     3301 aagacggcaa caccattcgt cgtcgaagag aatgtgaaca gtgtcatact cgctttacta
     3361 cctttgagcg tgttgaagaa ctccctttat tagtcatcaa aaaagatggc acacgagagc
     3421 aattttctag agataaaata ttaaatgggg ttgtccaaag tgcgcaaaaa cgacctgtct
     3481 cgagcacaga tattgaaaat gtcatttctc gtattgaaca agaagttcga acaacctacg
     3541 aaaatgaagt gtcaagtact gctattggta atttagtgat ggatgagttg gccgaactcg
     3601 atgaaatcac atatgtacgc tttgctagtg tctacaagag tttcaaggac gttgatgaaa
     3661 tcgaagaact tttgcaacaa attacgaatc gcgtacgcgg aaagaaaaaa cgtttaaata
     3721 atgatgaaac caattgatac ttttacatat ctaaaacgca acaaagtaac tcttgattcg
     3781 gtgactctaa tacagttgta ctttccaatt attggaagtg acgcggtctc tatctatcaa
     3841 tactttattc acttttttga cgatggttta caacgtcata aattcagcga tattttaaat
     3901 cacctacagt ttggtatgaa acgttttgaa gatgctcttg ccatattgac agcaatggaa
     3961 ttagtgagtg tgtatcagct atcagataca tatctcatta cgttgcacca gccgcttagc
     4021 cgtgacttgt tttttcaaca tccagcttat tctcgattat tagaacaaaa gattggagag
     4081 gtagctgtct ctgagttgca ggtaactgtc ccaagtcaag caagaaatat ttctaagcga
     4141 ttttcggata tttttggggt gcaaggagat ttgacgaacg tacctcaaaa gccacaaaag
     4201 aattttgacc tttcaagttt ccagcaatta atggttcgtg atgggttaca atttgaagat
     4261 aatcaaaaag atatcattag cctttacagt attgctgaac agtatgatat gacgtggttt
     4321 gatacttatc aaatagctaa ggcgacggct gttaatggga aaattcgacc tgaacgctta
     4381 ttggctaaaa aaaatcaaag catgacaaaa ccaagcaaag aaaatttttc acaggctgag
     4441 caaattattt tgcgagaagc aaagcaagac agtgctttag tctttttgga aaaaattaaa
     4501 aaggctagac gtgcaacgat tactaaggat gaacgcattt tattgcaaac attggccaaa
     4561 atgaattttc ttgatgatgt tatcaatgtc atggtgcttt atacctttaa taagacaaaa
     4621 tctgctaatt tacagaagag ttatgtctta aaaatggcca atgatttcgc ctaccaaaag
     4681 gtgtcaacgg ctgaagaagc tatagtggtt ttgcgagcct tcacggatcg tcaaagtcgt
     4741 cggcaatcaa aagtaaaaac aagtcaaagt aatgtgccta agtggagcaa tcctgattac
     4801 caagagacaa caagtcaaga agagcaggcg aaactagatc agttcaaaca ggctgctttg
     4861 aagaggttag aaaacctagg aaaagggggt gactagatgg aaaagattgg agaaaccatg
     4921 gcgaaattgg gtcaaaacac tcgtgttaat agcgaccagt tgattcaaac cattttagcg
     4981 gatcctgaag tagcaagctt catcagtcaa catcacttat ctcaagagca aattaacctt
     5041 agcttatcta agttcaatca atttttggtg gaacgccaga agtatcaact caaagatccc
     5101 tcttatattg ctaagggcta tcagcctatt ctagctatga atgagggcta cgctgatgtg
     5161 tcttatttgg aaaccaaaga attggtagaa gctcaaaaac aggcagctat ctctgaacgg
     5221 attcaactgg ttagtttgcc aaaatcctac cgccatattc atttatcaga tattgatgtt
     5281 aataatgcga gccgtatgga agccttctct gctattttag attttgtgga acaataccca
     5341 tcagcagagc aaaaaggctt atatttgtac ggagatatgg gaattggcaa gtcttacttg
     5401 ttggctgcta tggcccatga attgtctgag aaaaaaggtg tgtcaacgac ccttctacat
     5461 tttccgagct ttgccattga tgtaaaaaat gccatttcaa acggctctgt taaagaagaa
     5521 atcgatgcgg tcaaaaatgt accagtgctc attttagatg atattggtgc agagcaagcc
     5581 acttcttggg tccgtgatga ggtgttgcag gtgattttac aataccgtat gttagaggaa
     5641 ttgccaacct tctttacctc taattaccgc tttgcggatt tggagcgaaa atgggcaacc
     5701 atcaaaggaa gtgacgaaac ttggcaggcc aaacgtgtca tggaacgcgt gcgttatttg
     5761 gctagagagt ttcatttaga aggggctaac cgccgttaag tttgagatag caatcaagaa
     5821 gaatagctac acgtatgagt gagtgaaaga aaaggagaat catggtttta cctaccgttg
     5881 ccattgtggg ccgtccaaat gtgggcaagt ccaccttatt taatcgaatc gcaggagagc
     5941 gcatttcaat tgtagaagac gttgaagggg ttactcgtga ccgtatttat gctactgggg
     6001 agtggcttaa ccgccaattc tcattgattg atacaggtgg tattgatgac gttgatgccc
     6061 cgtttatgga gcaaatcaag caccaggctc aaattgctat ggaagaagcg gacgttattg
     6121 tctttgtcgt ttctggtaaa gaaggggtga ccgacgctga cgaatatgtg tctaaaattc
     6181 tgtatcgaac caatacccca gtcattttag ctgttaataa ggttgataat cctgaaatgc
     6241 gtaatgacat ttatgatttt tattcacttg gtttagggga tccctatcca gtttcttctg
     6301 ttcatggtat cggaacaggg gatgtcttgg atgcgatcgt tgaaaacttg ccagtagaag
     6361 aggctgaaga aaatgatgat attattcgct tcagtttaat cggtcgtcct aatgttggga
     6421 aatctagctt gattaacgct attttaggtg aggaccgtgt tatcgctagc cctgtcgcag
     6481 ggacaacacg tgacgctatt gacacgcatt ttacggatgc tgacggtcaa gaatttacca
     6541 tgattgacac ggctggaatg cgcaaatctg gcaagattta cgaaaataca gagaaatatt
     6601 ctgtcatgcg tgccatgcgt gccattgacc gctccgatgt ggtcttgatg gttatcaatg
     6661 ctgaagaagg tatccgtgaa tacgacaagc gtatcgctgg ctttgcacac gaagctggta
     6721 aaggaatgat tatcgtggtt aacaaatggg atacccttga caaggataat cataccgttg
     6781 ctaagtggga agccgatatt cgtgaccaat ttcaattttt gacatacgct ccgattattt
     6841 ttgtgtcagc tttgacgaag cagcgcctca acaaattgcc tgacttgatt aaacgtatca
     6901 gtgagagtca gaataaacgt atcccatctg ctgtcctcaa tgatgttatc atggatgcta
     6961 ttgccattaa tccaacacca acggataagg gtaaacgttt gaaaattttc tatgccactc
     7021 aagtgtcagt aaagccacca acatttgtcg tctttgttaa cgaggaagaa ttgatgcact
     7081 tctcttatct acgcttcttg gaaaaccaga ttcgcgcagc ctttaccttt gaagggacac
     7141 cgattcatct gattgctcgc aaacggaaat aagaaatgaa catcaactaa aatgctgacc
     7201 taagaaataa tctcatcatt gataaggact gtgttgtgta tgttacagga gacagtcctt
     7261 tttataatac ctttaagggt gtagacggaa gattagtagc aaacaaagaa aaaggatttt
     7321 gacaagaaat atcagtcggt ttttgctata atgaaaggat aagcaaaaag gtggaaaaat
     7381 gatggctaga ttaattccag gacgagtaag gaatgaaggt attaagcttt atgagcaagg
     7441 tttagtctca ttccaagatg ataataaagg cattcttcaa atagaagtgg agacttatca
     7501 ggttcaatat ggagcagatg atgaggatat cacttgtcaa tgcgacacat ttcatatgaa
     7561 acattattgc aagcatattg cagcagtcga gtatttttta aaaaatgatc aaaaaggtaa
     7621 gcttttttta aaacagttaa caaatcaaac aaaaatcaaa gaaacaacaa agaaaatgac
     7681 atcttttggt agcctctttt tagatagctt agccatgaat gaagatgatt ctgttaaata
     7741 caggctgtct gctcttggta gtcgaagcca tttttcgtca gattactggt ggagtctgaa
     7801 aatcaatcgt ttaccagatg atcgttctta tgtgattcga gatattaaag gctttttgca
     7861 gcttattaaa aaagaaggct tttatcagat tggaaaaaat tattttgaac aactttcatg
     7921 gctgcagttt gacccatcca gtcaagacct tattgagttt ttatggcgct tagcatctga
     7981 tactgacaaa ggggacaatg agaacatttt tccaaatcat gcaaggcatt tgcgcttacc
     8041 tagtggtttt tttgaagaag gcattcacta tttgacgtca ctttatgact ttacttttga
     8101 ggggccttct caaacttatc atcatctttt tgtccgttct ttggaagcag aggcaggcct
     8161 ttatgagttt aaagtggaag tgcatcgcaa atctattgaa ttgcaaattg ctgaaaaaaa
     8221 tgtgcaatac ctctttgata atgactatct tctttatcaa gatacctttt atcacttgac
     8281 gttaaagcaa cgaaaaatgg ttcaggctat tcgtagtctg cccattgagg ccgacttggc
     8341 taaacatatt cattttgatt tggatgatca tgcgaaatta gctgcaagct tatcagattt
     8401 taaacagatc ggtctagtag aggctcctaa aagctttgct attagagact ttgaggtgac
     8461 ttttcaattt gatttgttaa atcgagatga aatcagttgt cagcttatgt ttgattatgg
     8521 caattaccaa gttagtgaca aagcaagttt agaagcactt ccttttgcta gtcatttaaa
     8581 aaaagaagaa aaaatcaatc gttctttact tgcttttggc ttctcgccac aattttactc
     8641 aaaaaagcga ctaacaagtg caaaagagct ctatactttt tttgaagaaa cagttccatg
     8701 ttttgagcgc ttaggtaatg ttgcgttgag tacagctatc caagcattac aagtgaaaga
     8761 aatgcccaag atcgctatta aacgcaatca ggggttacta gacatctcgt ttgatttttc
     8821 aaccattatt gaaaatgata ttgaccaagc tgttacagct ctttttcaaa ataatcctta
     8881 ttttgtgagt caaacaggtc aattagtggt ttttgatgat gaaactcaaa aagttagcaa
     8941 aagcttacaa gaattaagag caagacagct aaaaaatggt cacttgcaac tggatggcat
     9001 tagagctcta caagtatcca aactttttga aggcatgaca tctgttcatt tttcaaagga
     9061 attagaagag ttagcctatc atttgcagca tcctgaaact ttttcaataa aaccgttacc
     9121 agttaaggct caaatgcgag attatcaacg caacggtgtt cagtggttat caatgctcaa
     9181 tcattatggc tttggtggca ttttagcaga tgacatggga cttggaaaaa ctctccagac
     9241 acttgctttt ttagctagtc acctgaaatc agatagtaaa gtgctcattt tatctccatc
     9301 tagtcttatc tataattggt ttgatgaatg tcaaaaattc acacctcagc tagatgttgt
     9361 ggtttcttac ggacttaaac aaaccagaga tcaaatcatc gaagaaggtc atcaaataac
     9421 cataaccagc tattcctcct ttagacagga ttttgagacc tatcaagcgt ttcactacga
     9481 ttatcttatc ttagacgaag ctcaagtgat aaaaaatgcg caaactaaga tttcacactg
     9541 tttacgtgcg tttaatacag ccaattgttt tgcgctttcg ggcactccta ttgaaaataa
     9601 aatgcttgaa atttggtcca ttttccaaat tgttttgcca gggttgctac cgactaaaaa
     9661 agagttttta aaattaacag ctgagcaagt atcacgctat atcaaaccct ttgtgatgcg
     9721 tcgtaaaaaa gaagatgtcc taccagaatt acctgattta attgaaacta attattcaaa
     9781 cgagatgaca gatgaacaaa aagctattta cttagcgcag ttaaggcaga tgcaagatca
     9841 aattcgaaat tctagtgatg tggatattag ccgtcaaaaa attgagattt tatctggtat
     9901 cactcgattg aggcaaatct gtgacactcc aagtctcttt atgaattacc aaggcaaaag
     9961 tggtaagcta gatagtttgc gaattttatt gacacaaatt aaagaaaatg gtcatcgggc
    10021 tttgattttt tctcaattta gagggatgct ggacttggcc aagcaagaga tgactgctct
    10081 aggattgacc tcttatcaaa tgacgggatc tacccctgcc aatgaacgtc aagaaatgac
    10141 tagagccttt aataacggtt ccaaggatgc ttttttgatt tccctcaagg caggtggagt
    10201 tggaatcaac cttacgggag cagacacagt gattttaatc gatttatggt ggaatcctgc
    10261 tgttgaaatg caggcaatca gtcgtgccta ccgtattggt caaaaagaaa acgttgaagt
    10321 atatcgctta atcactcgag ggacgattga agaaaagatt ttagagcttc aagaaagtaa
    10381 gcgcaatttg gtgactacag ttttggatgg caatgaaagc cgagcaagta tgtccattga
    10441 agaaataaaa gaaattttgg ggctaaacac tcattaatct tccttgattt tagtgacatt
    10501 aaaaaccctt taaagaagat gacaccaaaa gcaccttata taacctcgtt aaaacgcttc
    10561 ttttgaaata tctttattga tatagcgatt gttatttgct agtaatgatt aaaacattta
    10621 gaaaaagaca agtcatagaa tcatcaagga atgctttgaa aaataacagt atttaagtta
    10681 taatagagga tgctacaaga agggagaatc aaaaaaggat ggtaaaaaat cagtttcctt
    10741 tagttgcaga tggcattgct attagtgatc cagcaaagca aatggctctg tatgaaaatg
    10801 aagatctcat taccaacatc cgtggctatt accaggacaa ggagtatgat gatattgctg
    10861 gaaatgagga gcttactgct aaagcaactt ctcggcaggc cccttctagt aagcgctttt
    10921 gtagcaatga tgaaaaacac cattatgtca aagaggcgcg tcaaaaagca aagcaagatc
    10981 tcaaggaaaa aagacaggct tatcttgcca aagaaatggc ctatgttcct aaacaggttt
    11041 ctaaaaagca acagcctgcg gattcttctc cttctcaaaa gcaagcaaca acagaaatga
    11101 gtcgttttac aaaaaagctt catcaagaca actatatttt agctgagttg ccaaaagaat
    11161 ataaagagcc aaaaaatctt cctcaacaag gaactacaaa aaaaaataat tacgattttt
    11221 taaaatccag tcaaatttac aacaataaag aaatgagaca acaacgagaa aaaacaattg
    11281 cgcaagagct taatcttagt aggtttgagg atcttcctta ataaatctac tcagcgtatg
    11341 cagatgacaa aggagttaag atgtcaaaaa cgtatcattt tatcggaatt aaagggtcag
    11401 gaatgagtgc cttggccctt atgttgcatc aaatggggca taaggtgcaa ggtagtgatg
    11461 ttgaaaaata ctatttcact caaagaggat tggaacaagc gggcattact atcttacctt
    11521 ttagcgagga caacattacg ccagatatgg aacttatcgt tgggaatgcc tttcgtgaaa
    11581 acaacaaaga agtggcctat gctttgagac accagattcc tttcaaacgt tatcatgact
    11641 ttttaggtga ttttatgaaa tcatttatca gttttgcagt agcaggtgct catggtaaaa
    11701 cttctacaac gggtttattg tcacatgtct tgaaaaatat cacagacaca tcttatttaa
    11761 ttggtgatgg tactgggcgt gggtctgcta atgcgcagta ttttgttttt gaatcagacg
    11821 aatacgaacg ccattttatg ccttatcacc cagaatactc tatcattact aatattgatt
    11881 ttgaccatcc tgattatttc acaggaattg ctgatgtgcg aaacgctttc aacgattatg
    11941 ctaagcaggt caagaaagct ttgtttgttt atggtgaaga tgacgaacta aaaaagatcg
    12001 aagcacctgc acctatttac tattatggtt ttgaagaggg caatgatttt atcgcttacg
    12061 acattacgcg tactacgaac ggatcggact ttaaggtaaa acaccaagga gaggtcattg
    12121 gtcagtttca cgtacctgct tatggaaaac ataacatttt aaacgctaca gcagtaattg
    12181 caaacttgtt tgtagccggc attgatatgg ctctagtggc agaccatctt aaaacttttt
    12241 caggtgtgaa acgtcgtttt acagagaaaa ttatcaatga cactattatt attgatgact
    12301 ttgctcatca tccaaccgaa attgtggcaa caattgatgc ggctagacaa aaatacccaa
    12361 gtaaagaaat tgtagcaata ttccagccac atacttttac tcgcactatt gccttattag
    12421 aggattttgc ttgtgcttta aatgaagctg acagtgttta tttagcccag atttatggtt
    12481 ctgcacgtga agtagataaa ggtgaagtta aggttgaaga tttggctgct aagattatca
    12541 aaccatcaca agtagtaacg gtggaaaatg tctctcctct tcttgatcac gataatgctg
    12601 tttatgtttt tatgggagct ggagatattc agctatatga acattctttt gaggaattac
    12661 ttgcaaattt aactaaaaat aaccaataac atgtcctgcc ttaggcaggt tttctcattc
    12721 taaaggagtt tgatatgttg attagacagg ttcaaggatc cgatttggaa gttattgcta
    12781 ccattgaaag tgacaatttt tcaccacaag aagcaacgac aagagcagtt cttgaagagc
    12841 gcatacggct gataccagat acttttttag tggcacttat cgatcaggaa attgttggct
    12901 atatcgaagg tccagttgtc actactccta ttttggagga ttctttgttc cacggggtga
    12961 ctaaaaatcc taaaactgga ggctacattg ctattactag tttgtccata gctaaacatt
    13021 ttcagcaaca aggggttggg acagctttgt tggcggcact aaaagattta gtagtagcgc
    13081 agcaaagaac aggtcttatt ttgacttgtc atgattactt gatttcctat tatgaaatga
    13141 atgggtttat taaccaagga atttcagagt ctcaacatgg tggaaccctt tggtaccaaa
    13201 tgatttggaa actttagaat cacagctgat tcaactgttg gtttgttaaa aataagtaac
    13261 aaatgcatca tttaattgca attaggatac ttttaagtta taatggcggt tgattatatt
    13321 taggaggatt ggctttgacc gattttaagg ataaagacca acaagatcag cagcgaagct
    13381 ttaaagagca gattcttgct gagttggaaa aagcaaatca aatcagaaaa gaaaaagagg
    13441 aagaactttt tcaaaaagag ttggaagcta aagaagcagc taggagaacg gcccagctgt
    13501 atgctgaata taaaagacaa gatacttttc aaaaagagtc tatagcacat aacaataaga
    13561 cagccaaaca ctttcaagct ataaaagatg cggtaatgac ttcagaagcg attaaaccga
    13621 ctttactttc tgaaaaagaa aactcatctt taaaaacgac aagtaagaga gtcgtgcagg
    13681 caaatgagct tcaagagact gcctctaaag aatctcaagt accgttaact attgagaaag
    13741 gtcattcagt gagacgaaaa ttaagcaaac gccaacagac tgagcgagct gctaaaaaga
    13801 tttcaaccgt tttgattagc tctattatta taaccctttt ggctgttact ctagcaggag
    13861 caggctatgt ttatagtgct ttaaatcctg ttgataaaaa tagtgatgcc tttgttcaag
    13921 ttgagatacc atctgggtca ggcaataaat tgattggtca aattcttcaa aaaaaaggtt
    13981 taatcaagaa tagcactgtt tttagttttt atacaaaatt taaaaacttt acaaattttc
    14041 agagcgggta ttacaatctg caaaaaagta tgagtctaga agaaattgct agtgctttac
    14101 aagaaggtgg tacagcagaa cctaccaagc catctcttgg gaagatcttg attccagaag
    14161 gatacacgat taaacaaata gctaaagctg ttgagcataa tagcaaggga aagaccaaaa
    14221 aagctaaaac accttttaac gagaaggatt ttttggattt agtcacggat gaggctttta
    14281 ttcaagatat ggtaaaaaga tatccaaaat tattagcaac tatcccaact aaagaaaaag
    14341 ctatttaccg tttggaaggt taccttttcc cagcaaccta taactattac aaagaaacta
    14401 ccatgagaga acttgtagag gacatgctgg cagctatgga tgctactttg gtaccctatt
    14461 atgataaaat tgctgctagt ggtaagacag tcaacgaggt attgaccttg gcctctttgg
    14521 ttgaaaaaga aggttcaaca gacgatgaca gacgtcaaat tgcaagtgtc ttttataacc
    14581 gccttaatag cggaatggca ctacaatcta atatagctat tttgtatgcg atggggaaac
    14641 ttggtgagaa aacaaccttg gctgaggatg ctactattga caccaccatt aattctcctt
    14701 ataatattta taccaataca ggtctgatgc ctggtccagt tgctagctcg ggggtttctg
    14761 caattgaagc aaccctaaat ccagcctcaa cggattattt atactttgtg gccaatgtcc
    14821 atactggtga agtttactat gcaaaaacat ttgaagagca ctctgcaaat gttgaaaaat
    14881 atgtgaatag tcaaattcag taaacacaaa catggtgctt aagcaccatg tttgtgtttc
    14941 tgattcgttt aaaaaagaaa agagagaaaa caattatggc agaaaaaacg tatccgatga
    15001 ccctaacgga aaaagaacaa cttgaaaaag aacttgaaga attaaaactt gtgcgtcgtc
    15061 cagaaatagt ggagcgtatt aaaattgcac gttcgtatgg agatctttca gagaactctg
    15121 aatacgatgc cgcaaaagat gagcaagctt ttgttgaagg tcaaatttca acgcttgaaa
    15181 ctaagattcg ctatgctgaa atcattgaca gtgatgctgt tgcaaaagat gaagtcgcta
    15241 tcggaaaaac agttattgtt cacgaagttg gaacaacaga taaagatacc tatcatattg
    15301 taggtgctgc tggagcagat atcttctcag gaaaaatttc aaatgaaagc ccgattgctc
    15361 aagctttgat tggtaaaaaa acaggtgaca aggttagaat tgaatcacca gcagctactt
    15421 atgatgttga aatcatcagc gttgaaaaga caagttaatc agatgaagcc attatttgcc
    15481 taaccactaa gtgttttggt tgctaatggc ttttctagta tcttcaaatg aggttgactg
    15541 ttaggaaggt caagtattaa tcgcattgat tatgagccaa gaggactata gatcaaagat
    15601 cgttttcgat agttatttaa taccaaaaga aaagaccagc accttaatgt actgacccca
    15661 aaaagttgga cactatattt taagtatagg aagtgtataa tctaaggaaa ctgacactaa
    15721 tgattgaccg ttttgcaaga ctttattaat gatttcttgc tttattttaa atgaataagt
    15781 ctgatacgtt tccttcctta acactatcga ctccataatg acccatcagt caaacggtat
    15841 atctcaaacg actacggttt actccaaatt gattggctag ttgaggccaa gaaacacctg
    15901 atttttttaa tgctaaattt ctagcttatc ttcatagctt aatttcatac aaaaacaccc
    15961 caatcgttag atttttttga tatgtcccct ttcactagat gagtccagta aaagggggca
    16021 tatcgttttt tgtctaactt ttggagtgca gttcataatt gtgctaggtt ttttgtcttt
    16081 cttaacgctt tcgctgtttt ccagcattac gattggattt tattttttta ggcaagttag
    16141 cctgttccat gttttgtgaa ggcgtaacat ccttacgaga agaagttgat tggtatgctt
    16201 taggcggggt tttagcgtat tcttctttaa tttgcttatg caatcgaggt tttaagaggt
    16261 aggttgtgat taactgttga ataatactaa agaaaccacc aactagccag taaagaccaa
    16321 caccagcagg gagtgagaag gacatgaaga tcatcatgat aggcatggtg tacatcatcg
    16381 tcttcatttg ctcacgttgc tcttctgaaa cggccatcat tgataaccat gattggaaga
    16441 agtaaagagc agcgataatt gctgttaaca ctaaactacg gctaccaaga tcaatgccca
    16501 taaaggtact tgttgatact cctttagtgt attgagcggc aaaatacatg gcagaaaaga
    16561 atggcatctg gatgagaaga ggtagacatc caatacctcc aagagggtta atcccatgag
    16621 cacgctgagc agccatcaat tctgtttggg cagccatttt ttcttcctga ctacttgcct
    16681 gtttgatacg tttgttgatt ggttcaaaaa caggtttcaa gaaggtcatt ttctcagatt
    16741 gataacttgc tttccaagat tgatagagac ctagtggtaa gataagtgtt ctaacaataa
    16801 tggttacgat gatgatagcc agtccataac ctagtccagc attgtttgca aagtaatcga
    16861 taaagtatga catgggtttt ccaagaaatt cccaaatcat acctttggga tttccgtgag
    16921 cgtctcttcc cacacagcct gtcaaggtga atagaattga cagtgctagt cctgaaaaga
    16981 ggatgcgatt taatgttagt ctcaatgtgt ttatccttta attttaatat acttatctat
    17041 tttacagttt ttttcagaaa ttcacaatag ttctgaaggc cgatttttaa ttgcctattt
    17101 gaaagtcctg aaagtcttca aaattagcca tggtgacatc cacataagtg acttttgccc
    17161 atttggatgg tcctttacga acttcttgaa taaatgtggc tattttatct gaatcttttg
    17221 attgggccag aatttcaacg gtcccatcgt tgttattcca gacacgacca taaatatctc
    17281 ctatatctag agctaaagta tgggtagcgt atcgaaaacc aacaccttgt acacgtccag
    17341 aaacaattaa acgtactttt tgcataagaa gggcctcctt gcttttatta taacacatac
    17401 ttagcaggaa atctctttag ctaattgtct acttcctgtc acttttacta aagacaagaa
    17461 tacaaaaatg agatagttag tagtactaac agtaaaagag gtttgtctat tttaaaaata
    17521 gtatcaaaaa aaggtctttt aggtttaaaa cattgaactg cctccaaatt gaccatctaa
    17581 gaagttgatg ctttcaaatg ctgtcgcgta tggtataata ggcgcatggt tattacatca
    17641 aaagcaaatc aactaattaa gcaaacaaaa aaattattgc aaaaaaagca tcgaaaacag
    17701 tcctatttga ttgagggctg gcaccttttt gaagaagccc aaaaatcagg acaagttttt
    17761 cgccacatct ttgttttaga ggaaatggtg gagcgtctag caggtgagca agaactcgtt
    17821 attgttagcc cacaagtgct caaggagttg actgactctc ctagtccaca aggcattgtt
    17881 gctgaggtgg agatacctaa gttagccttt ccatcagatt acaaagggaa atatttggtt
    17941 ttagaggacg tccaagaccc aggaaatctt gggaccatca ttcgtacagc agacgctgca
    18001 cggtttgatg gggtctttct ttctgaaaaa tcagcagata tttacaacca aaaaacccta
    18061 cgttccatgc aaggtagcca ttttcattta ccaatttggc gaacagatgt ctatcagctt
    18121 tgtcgagagc tccaagagta taaaactccc atcctagcaa caactctgtc aaagaaatct
    18181 gttgactata aaagcctcac acatcatgaa aggttggctt tggtgttggg aaatgaaggc
    18241 cagggcatta gtgctgaaat ggcagcccta gcagaccaac tggttcatat tacaatgcct
    18301 ggtcaggcgg aaagtttgaa tgttgccgta gcagcaggaa ttctcatttt cagcttgatt
    18361 taagctaata tgatataata accaagtgag gtaattatgt tatgcattat acagaagata
    18421 aagaatatat ggaacacgtc ggccatttga tcgctcatcc tcgctttcaa aaattgagtc
    18481 atattgttca gcaccaacat tcaacgcgtc ttgaacattc tatcaatgtt tcttattcaa
    18541 gttataaatt agccaagcga tttggttggg atgctaaaag tacagccaga gggggcttac
    18601 ttcatgattt cttttattat gattggcgcg tgaccaagtt taataagggt catgcctggg
    18661 ttcatcctcg tattgctgta cgaaatgcga aaaagttaac agaactcaat aaaaaagaag
    18721 aggatatcat tctaaaacac atgtggggag cgaccattgc ttttccacgt tacaaggaaa
    18781 gttatattgt gacaatggta gataaatact gggctgtcaa ggaagcagtg acgcctttga
    18841 gacaaaaatg gtctaatcga cggtttcttc gccgcaagac cctccaaagt cataatcgtt
    18901 aagtaaagga gttattatga acgatcacgt tatttataca caatcagatg tgggattaaa
    18961 tcagtttttt gctaaaattt atagtctagt gggaatggga gtgggtttgt ctgcttttgt
    19021 ttcttatttg atgctttatc catttagaga aaatttaatc tctattcttg ttaatcagcc
    19081 gatgatttac tatggtgctg cgattattga acttatttta gtttttatag ccagtggtgc
    19141 agcacgaaaa aacacaccag ctgcattgcc catttttctt atctattctg cgctaaatgg
    19201 ctttacccta agctttatta ttgtggcata cgctcaaacg acagtttttc aagcatttct
    19261 ttcttcagca gctgtgtttt ttgccatgtc aatcattggt gtcaagacta aacgggatat
    19321 gtcaggtctt agaaaggcta tgtttgctgc tttgattggt gttgttgtgg ctagtctgat
    19381 taatcttttt attggtagtg ggatgatgag ttatgtcatt agtgtgattt ccgtgctaat
    19441 tttctcaggt ctcatcgcat cagataatca aatgattaag cgcgtttatc aagcaacaaa
    19501 tggccaggtt ggtgatggct gggctgttgc tatggcctta agcttgtatt tagattttat
    19561 taacttattt atcagccttc ttcgtatttt tggaagaaat gattaacatt aaaaagtgag
    19621 tataactact cactttttaa tgttaacagg ataagtaaac tgtaaggaag aaattcgaga
    19681 tagatataag atgaggctgc taaaagacct agtgttaatt tgtaaactct ttcttttttt
    19741 ggtatactat taaggattaa atacgaggag aatatagata gatatgtcaa cagctatttg
    19801 gattttatta cttattgttg cccttggggt aggtgttttt ggtgggattt ttattgcccg
    19861 taaacaaatt gaaaaagaaa ttggtgaaca cccacgttta acaccagaag ctatccgtga
    19921 aatgatgagc cagatggggc aaaaaccaag tgaagcaaaa atccaacaaa cttatcgtaa
    19981 tatcatcaaa caatcaaaag cagccgtatc caaaggtaaa aaataaaagc taattgttat
    20041 aggggaaacc tttgtgatag ttagaagtga acagtctttg atctcaatgt tcagtagcac
    20101 ttgtcttatc agttagattt gtcaactgtt cagggtttaa aaagaaactc agttggctat
    20161 ttccaactga gtttttcata tcgtcagtaa ggaagtaaag ataatggata caagaccaat
    20221 tgggttttta gattctggtg tgggaggtct gaccgtcgtt tgtgaattga ttcgtcagct
    20281 ccctcatgag aagattgtat atattggtga ttcagcaaga gccccctatg gtcctagacc
    20341 caaaaaacaa attaaggagt atacttggga gctagtcaat tttttgctga ctcaaaatgt
    20401 taaaatgatt gtttttgcat gcaataccgc aacagcggtg gcttgggaag aagtaaaagc
    20461 agctttagat attcctgttt taggggttgt cttaccgggg gcaagcgcag ctattaaatc
    20521 aacgacaaaa ggccaggttg gggtcatcgg aaccccaatg acagtggctt cagacattta
    20581 tcgcaaaaaa atccagctat tagcaccatc tgttcaagta aggagtcttg cttgcccgaa
    20641 gtttgtaccg attgtggaat caaatgagat gtgttcgagt atagctaaaa aaatagttta
    20701 tgacagtcta gcaccattag tcggtaaaat agataccctt gtactaggat gtactcacta
    20761 tcccttgtta cgaccaatta tccaaaatgt tatggggcca tctgttaagc tgattgacag
    20821 tggagcagaa tgcgtccgag atatctctgt cttattaaac tattttgaca ttaacggtaa
    20881 ctatcatcaa aaagctgtcg aacaccgctt ttttacaaca gcaaattctg agatttttca
    20941 agaaattgcc tcgatttggc tgaaacaaaa aataaatgtg gagcatgtca ccttatgagt
    21001 gaaaaaattt acgaatacaa agatgaaaat aactggttta tcggaaagat gactggtcat
    21061 aatttaatat cgggctgggg agtcaaacac acgacaatca aaaaaataga tgacctttta
    21121 gacggtattg ccgcaacgtt agattgggaa aatcctaaag gttacgatgt ttcggtggtg
    21181 cgttatcagt ctcctttatc tctcatcacc tttattatcg acatgataaa tcaagagacc
    21241 cagcgtaaga ttaaggtaac tccccatgca ggcacgattt tattaatgga aaatgcgaaa
    21301 ctgcttgcag tttatctccc agaaggtgga gtttcaacgg ctacattttt tgcgactagt
    21361 gaacagggat ttggggatat tattttaatc gctacacgaa acgagggaaa aaccaaagag
    21421 ttccgcaatc tgtttggcca gctaggttat cgtgtggaaa atctcaatga ttatccagaa
    21481 ttgccagaag tagcagaaac tggtactact tttgaagaaa atgctcgctt gaaagcagaa
    21541 acgatttcac gcctcacagg aaaaatggta ttagcagacg attcaggact aaaagttgat
    21601 gccttgggtg gtttacctgg tgtttggtca gctcgtttct caggaccaga tgccacagat
    21661 gccaagaata atgccaaact cttacacgaa ttagctatgg tgtttgacca aaagaagcgc
    21721 tcagctcaat ttcatacgac tttagtagtg gctgctccca ataaagatag tttggttgtg
    21781 gaagccgagt ggccaggcta tattgctacg cagcctaagg gagaaaatgg ttttgggtat
    21841 gatcctgtct ttatcgtcgg agagactggg cgtcatgctg cagaattaga ggctgaccaa
    21901 aaaaatcagt tgtcgcatag aggtcaagca gttcgaaaat taatggaggt ctttccagca
    21961 tggcaagcaa aacaatcata gtaatgagtg actctcatgg tgaccgagat atcgttcaag
    22021 ccattaaaga taagtatctt ggtcaagttg atgctatttt ccataatggg gattctgaat
    22081 taaacagctc agatcctatt tgggctggta tttatgtcgt tggcggtaat tgtgactatg
    22141 atacaggtta ccctgatcgt ttagtaactc aattaggcac agttacgatt gcccagacac
    22201 atggtcactt gtaccatatt aatttcactt gggataaact ggactacttt gctcaagaag
    22261 tagcagcaga tatttgtcta tatggacacc tacaccgtcc agctgcttgg caagttgggc
    22321 aaaccctctt tatgaatccc ggatcagtaa cacaacctcg cggagaaatt aacgagaaat
    22381 tatatgctcg tgttgaacta actgatactc aaattaaagt tgattacttt acaagagatc
    22441 ataaacttta cccatcactg tctaaggaat ttaaacgatg atcgcaaaag aatttgaaac
    22501 gtttttaatg agtcatttag ataattatct tatcccggaa caagacttgg ctatttttat
    22561 cgacacacat aatgcagacc atgtgatgtt acttttggtg agtaatggtt tttctagagt
    22621 tcctgttatc acacgggaga aaaaatatgt gggaaccatt agcatctcag atattatgat
    22681 gtaccaatct aaaaggcagc tgacagattg ggaaatgagt caaacagata ttggcgagat
    22741 ggttaatacc aaaattgaaa ccattagcat tacttctagc ctaacagaaa ttatgcacaa
    22801 gttaattgat tacccattct taccggttgt agatagagcg aatcgctttg ttgggattat
    22861 tacgcgaaaa tctatattaa aggctgtcaa cagtctttta catgatttta cagatgatta
    22921 cacgattata aaaaaatgaa gagttatatt gaacctttta ttgctagcaa ggctttatct
    22981 caaaatagtc aaaaagctta tcgatacgat ttgcaacagt tttgtcaact ggttggtgaa
    23041 cgtgtcaatc aagacaaact attactttat caaaatagca tagctaacct aagtttatct
    23101 gcaaaaaaac gcaaattatc aacagctaat caattcttat attacttgta tcaaataaag
    23161 tatttaaata gctattttcg attaacagat accatgaaag tgatgcggac tgagaagcag
    23221 caagctgcta ttattaatac tgatattttc tatcaaaaaa ccccttttgt gtgggggcaa
    23281 ttaatcagct tattaatatt ggagctgggt ttaactccga gtgaagtagc tggtattgaa
    23341 gtagctaact tggatttaaa ttttcaaatg ttgacgctaa agactaaaaa aggtgtgcgt
    23401 gtattacctt tgtcgcaaat actaatccct tttttagaac aacaactcat tggcaaagaa
    23461 gtctatcttt ttgaacatcg aggcatccct ttttcaagac aatggttttt taatcaccta
    23521 aaaacctttg ttcggagtat tggttatgaa ggattaactg ctcaaaaatt acgagagcaa
    23581 tttattttga aagaaaaact agctggtaaa tcgataatag aacttagcga tattcttggg
    23641 ctgaaaagcc ctgtgacctt agaaaaatac tacaaatcat aatggatata aaacttaaag
    23701 attttgaagg tcctcttgat ttactcttgc acttggtatc acagtacaaa gttgacatct
    23761 acgaggttcc tattgttgag gttattgagc agtaccttaa ttatattgaa accttacagg
    23821 taatgaaact tgaagtggct ggtgactaca tgctgatggc aagtcagctc atgttaatca
    23881 aaagtagaag gctattacca aaggtggtag aacacatcga agaagaagat ttagaacaag
    23941 atctgttaga aaagatcgaa gaatatagtc gctttaaagc agttagtcaa gcgttagcga
    24001 agcagcatga ccaaagggca aaatggtatt caaaacctaa acaagaatta atttttgaag
    24061 atgctatctt acaagaagat aaaacggtga tggatctatt tctagctttt tcaaacataa
    24121 tggcagctaa aagagcagtt ttaaaaaaca accatacagt catcgagcgt gatgattata
    24181 agattgaaga catgatggct tctattaaac agcgactgga aaaagaaaac gttattagct
    24241 tatcagcgat ttttgaggaa tgccaaacat taaatgaagt tatcagtata tttttagcta
    24301 gtctagaatt gattaagctt cacgtggtat ttgtagagca gctctctaat tttggggcta
    24361 tcatactacg aaaggagaag aaatgacgta tttgtcacag atagaagcgc tgctatttgt
    24421 tgcaggtgaa gaagggttaa gtttgcgaca tctagcgtct atgttatcat taacgccaac
    24481 agctcttcaa cagcaattag aaaaactctc tcaaaagtat gaaaaagatc aacattctag
    24541 tctttgtttg atagaaacag ctaataccta caggctagta actaaagaag gttttgcaga
    24601 actcttgcgt gcttatgcca aaacaccaat gaaccaaagt ctatctcgtg cgagtttaga
    24661 ggtcttgtct attgttgcat acaaacaacc tattacacga atagaaattg atgacattcg
    24721 aggggtaaac tccagtggag ctttgagtaa attattggca tttgatctca ttagagaagc
    24781 tggcaaaaaa gatgtggttg ggcgtcctca tttgtatgcg acaacagatt attttctgga
    24841 ctatatggga attaatcatt tagacgaatt gattgaagta tctgccgttg aaccggcaga
    24901 tgaagagatt gctcttttta ggacacaaga ctgagttttg cttgtcatca aatagcaaat
    24961 gacgtttaca aaaagatttg ttttaaggcg ttttagttga aaaaagcctt aaactaggga
    25021 caacaaaaag ttgctcaaaa gaaagaagaa tataatgcga attaacaaat acattgccca
    25081 tgcgggtatt gccagtcgtc gtaaggctga agaattgatt aagcaaggct tagtaacctt
    25141 aaatggtcag gttattacag atttagcaac cactgtaaaa tcgggagacg tggttgaaat
    25201 agaaggaagt cctatttaca acgaggaaaa ggtttactat ttgcttaata aacctcgtgg
    25261 cgctatctca agtgtgtcag atgacaaagg ccgtaaaacg gtactggatt tactacctca
    25321 ggttaaagaa cgcatatacc ctgttggacg attggattgg gacacatcag gggtccttat
    25381 tttaacgaat gatggtgatt ttacagatac tatgattcat cctagaaatg aaatagacaa
    25441 ggtttatctg gcgcgtgtca aaggaattgc aacgaaagaa aatcttcgtc ccttaactcg
    25501 aggaattgtt attgatggta aaaagaccaa accagctcgc tacaatattg ttcgtgtaga
    25561 agctgataag aatcgatcga tcgtagaatt gactatccat gaagggcgaa accatcaggt
    25621 taaaaaaatg tttgagtctg tggggctttt ggttgataaa ttatctcgta cacgttttgg
    25681 gaccgtcgac ttaaagggac taagaccagg agaagcaaga cgcttaaata aaaaagaaat
    25741 aagtcaactg cataacttag ctaatacgaa aaaatgatga aaaaactatt aatagtatct
    25801 gttaaagctt atcaaaaata catttctcct ttatctcctc ctagttgtcg ctacaagcca
    25861 acctgttcag cttatatgtt aactgctatt gaaaaacatg gtactaaggg aatactaatg
    25921 gggatagcaa gaatattaag atgtcaccct tttgttgctg gtggtgtcga tcctgttcca
    25981 gaagatttta gcctaatgag aaataaaaac acgtctaaaa acgctgaaaa ggcatgactt
    26041 tatcaaaaaa tggcttgaca ttgatagctg aagtgttata atggaaaaca agcattcgtt
    26101 ggtttaaatc aaacctgtta tgatttaagt tagcgagtca ccatcaacca cattgtttgc
    26161 tgagcatgac tccgagcagt gtggtttttt aaattaaaaa gagtaaatga gattatgacg
    26221 acaaaagaac ttatcaacaa aaacgacaaa gtaaaaaagg ctcgcaatca tattgtcctg
    26281 tttcaacccc aaattccaca aaatactggt aatattgcta gaacatgtgc tgcaactaat
    26341 gcacctttac acattattaa acccatggga tttcctattg atgaccgcaa aatgaagcgt
    26401 gccggcttgg attactggga caagttagaa ctgcattttt atgatcattt agaacagttt
    26461 atcaatcaat gtcacggaca gcttcacctg attagcaagt ttgcagttaa taattattct
    26521 caagctactt atgctgatgg cgattcccat tatttcttgt ttggacgaga agatacaggc
    26581 ctgccagaag attttatgcg agaacatgct gaaaaagcac ttcgtattcc gatgaatgat
    26641 gagcatgtac ggagtttaaa tgtctcaaat acggtttgta tggtgattta tgaagccctt
    26701 agacaacagg gctttcaagg gttagagtta aagcatactt acgaacacga taaactaaaa
    26761 taatgtactt tttaaaagcg tcagtttttg gcaatatgcg ttgtcagtag ctgacgcttt
    26821 taaaaattta gtcaaagcta ttgctatcta ggtttaaatc tgctatgcta gaagtgtctt
    26881 cagggcaggg tgtgattccc gaccggcggt gactagtaac tagaagtccg cgagcgcaag
    26941 ctgatgtggt ataactccac aaccgacagt atagtctgga tgagagaaga ccgggctttt
    27001 tgtgtaggct tattttagct acacaataac gacggaactt ctttcaattt gaaaaaattg
    27061 gaggaatttt ttaatgtcaa aaacacataa aatgattatg attggtatac tttctgcgat
    27121 atcatttcta ttgatgctag ttagctttgc cattattcca ggcgcagctt ttttaaaaat
    27181 tgaatttagt attattcctg tcctatttgg tttaatgatt atggacttaa agagtgctta
    27241 cttgattttg ttattgaggt ccttattgaa actctttttg aacaatcgtg gggttaatga
    27301 ttttattggt ctcccaatga atattatcgc tatcgcttta tttgtgacgg cttttgcctt
    27361 agtttggaac cgtcaaaaaa cgcttagtca atatgtattt gctagcttac taggcacagg
    27421 gttattaaca tttggcatgg ttgttctcaa ttatactttt gccattcctt tatatgctat
    27481 atttgcaaat attgatatca gagcttatat tggtgtcact aagtatatga tgactatggt
    27541 tattccgttt aatcttgttg aagggttgat atttgcaatt accttttatt ttgtgtatat
    27601 tgcaagtaaa ccaattttag aaagatactt acactaatat gatgacaaat aaacaaactc
    27661 actttttaat agcttctttt gcattactaa tctttgttat aataggctat acggtcaaat
    27721 tttttcctga acgtttggca cttctagata atactattca agcagagatt agaggcaacc
    27781 ttcctatagt gctgacgcaa ttctttaggg gtgttactgt atttggaaat gtcatgacac
    27841 aaattttgtt agttattgtg tcggttctag ttttattctt tatgaagtgg aaaattgaag
    27901 ccttgtttat cttatcaaat ggtgctattg cagcattttt gattacgact ctcaagctct
    27961 tttaccaaag accaagacct gctattgagc atttggttta tgctggtggc tattcgtttc
    28021 ccagtggcca tgcgatgggt agcatgctga tttttggtag cctattgatt atttgttatc
    28081 aaaggctaca ttcaaaacta ttacaatttg tgactagcat gatctttata atactaattt
    28141 tagtaattgg gttatctcgt atttatctag gggtacacta cccaagtgat attttagcag
    28201 gctttgtatt aggattcggg attctgcagt ttatttatcc tttttataag caaaaacgat
    28261 ttgaatggcg atttcttttg aaacaagact aatttttctt gagaagacat agggcttatt
    28321 taaatcattt agaataacat tggcaagcat caccccttga ttgccagtgt tattttagtt
    28381 ttagttagat gatgtgagct gatgattagt aaatatgttt agatgaaaaa tgattaaagt
    28441 gctatgtaac gtcagaaaag acgtgatttt tgttgatctg taatcattaa gtaagctgat
    28501 gtagaagtag tgaattctaa tgactgagct atcttttgca tagatgacta tcttgctagt
    28561 aatgatttgt gctacaatag aaacatgaaa aaaagatatc agacattaaa cgagcattac
    28621 cgtcaactat ttggcgcaaa aatgtttaaa gttccgattg atgccggctt tgattgtccc
    28681 aatcgtgatg gaacggtagc tcatggagga tgtacttttt gcacagtatc aggttctgga
    28741 gatgctattg tagcaccaga tgctccaatt aaagagcaat tttataaaga aattgatttt
    28801 atgcaccgta aatggcctga tgtcaatcgc tatttggttt attttcaaaa ctttaccaat
    28861 actcatgata cagttgatgt gattcgcgac cgttacgaac aagctattaa cgaacctgga
    28921 gttgttggca ttaatattgg cacacggcct gactgtctac cagatgatac cattgcttac
    28981 ttagcagaat tatcagaacg catgcatgtg acagtggagc taggcttaca gacaacttat
    29041 gaagaaactt ctaggctaat taacagagca cattcttatg atttgtataa agacacggtg
    29101 aggcgactaa ggcattaccc caacattaat attgtctcgc acttgattaa tggattgcca
    29161 aaagaaaccc atgacatgat gcttgaaaat gtgagacgct gtgtaacaga caatgacatt
    29221 caaggaatta aattgcattt gctgcatttg atgaccaata ctagaatgca aagagattat
    29281 catgaaggac gcttaaagtt gttgagtcaa aaggactatg tttcgattat ttgtgatcag
    29341 ctagagatta tccctaagca tattgtgatt caccgtatta caggagatgc cccacgcgat
    29401 atgttgattg ggcccatgtg gagtctaaat aagtgggaag tattgaatgc cattgataaa
    29461 gaaatggaaa gacgaggaag ctttcagggc tgtaaagttg actaatttgt ctcattttga
    29521 cggatttgga taggagaaaa gtgatgctaa aacgccccat tcatctctcg catgattttt
    29581 tagcggaggt tgtggataag tctagtgtgg ttgttgatgc cacgatgggt aatggaaatg
    29641 atactgcctt tttggcacaa ttagctaaaa aggtttatgc ttttgatgtg caagaacaag
    29701 ctattagaaa aacaagtgag cggttagcgc agctaggatt attgaacgct gagctgattt
    29761 tagcgggtca tgaagcagtt gatcagtatg tgacagagcc ggtgcgcgca gcgattttta
    29821 accttggtta tttgcccagc gcagataaat ctattattac cttaccaaat accacactcc
    29881 aagctttatc aaaactacta acgttattaa tggtaggtgg acgtattgct attatggtct
    29941 attatgggca tgatggaggt agtttggaaa aagatgcttt attagatttt gtcaagcaat
    30001 tagaccaaag aaaggtttct gcaatgcttt atcagcctct taatcaggtg aataccccac
    30061 cttttttaat catgttggag aagttagcag acgtttagcc cttatccctg tgtcaagtct
    30121 actagaagtt ctgcgattat ttcggtggaa aaagaagaaa tcccataggc tttggctata
    30181 aatgtgatat aatgaagtca ctatattatt tttttaggag ttacattaac atggaagacc
    30241 ctgtgagtca gcccttagtg attcaatttt tattgttagt tgttttaacc ttgttaaatg
    30301 cttttttttc agccagtgaa atggccttag tttctctcaa tcgttctcgg gtggaacaaa
    30361 aagcagcaga cggtgataaa aaatacgctc gtttgttgcg ggttttagag gaacctaatc
    30421 attttttatc aacgattcaa gttgggatta cctttattag tttactatca ggagcaagtt
    30481 tatcagcttc tttgggtaag gtgatctcag gttggctagg taattcagcg actgcaagga
    30541 cagctggtac tatcatctcc ttggttttct tgacttatgt ctctattgtt ttaggagaat
    30601 tgtatccaaa acggattgcc atgaacctca aagacaagtt ggcgatcgtt tcagccccta
    30661 ttatcattgg gttggggaga ctggttagtc cttttgtgtg gctcttatct gcttctacta
    30721 atttgctgag ccgacttacc ccaatgacct ttgatgatgc agatgagcaa atgacacgtg
    30781 atgaaatcga gtatatgtta tcaaaaagtg aggcgaccct tgatgctgaa gaaattgaga
    30841 tgttgcaagg agttttctca cttgatgaaa tgatggcgcg tgaagtcatg gtcccaagga
    30901 ccgatgcttt catgattgac attaacgatg atccgcttga aaatattcag gaaatcttaa
    30961 aacaaagttt ttcacgcatt cctgtttatg atgtggataa agataaaatt atcggtctca
    31021 tccacactaa gcgtctcttg gagtcaggtt tccgccaggg atttgatcag attaacatgc
    31081 gaaaaatgtt acaagaacct ctttttgttc ccgaaaccat ttttgtagat gatctcttac
    31141 gccagctgcg caatacccaa aatcagatgg ctattttgct agatgaatat ggtggtgtgg
    31201 caggacttgt gactttggaa gacttgcttg aagaaatcgt cggtgaaatc gatgatgaaa
    31261 ccgataaagc agaacaattt gttcatgaga ttggagacaa tacctatatt gttgttggta
    31321 ccatgacttt aaatgagttt aatgactatt ttgataccga actagaatca gatgatgtag
    31381 ataccattgc tggtttttat ttgacaggta tcggaaccat tccaagccag gagcaaaaag
    31441 aagcctacga aatagataac aaagacaaac atttagttct aatcaacgat aaagtcaaag
    31501 atggccgtat tacgaaatta aaattaatcc tgtctaatat agaacagatt attgaggaag
    31561 actaggctcc atgcctagtc tttttgatga aaagtgttat aatgaaaatg taaaaacgtt
    31621 tacaagtaat gaaggagatg caatgactga gaaagattat ggacaagtaa cagggatggt
    31681 gcattcgaca gaaagttttg gttctgtaga tggtccaggc attcgtttta tcattttctt
    31741 gcaaggctgt aaattacgtt gccaatattg ccataatccg gatacttggg agatggaaac
    31801 caacaattca aaaatcagaa cagtcaatga tgtcttgaaa gaagcccttc agtacaaaca
    31861 tttctgggga aaaaaaggag gaattaccgt atctggtggt gaagctatgc ttcaaattga
    31921 ttttatcact gccttattca tcgaagctaa aaaattaggt atccatacca cactagacac
    31981 ctgtggcttt acctatagac cgacacctga ataccatcag gttcttgata acttattggc
    32041 agtgaccgat ttgattttat tggacttgaa agaaattgat gaaaaacaac ataaaattgt
    32101 gacgcgtcag cctaataaaa acatattgca atttgcgagg tatttatccg acaagcagat
    32161 tcctgtctgg attcgacatg tcttggttcc aggcttgact gatattgatg atcatttgac
    32221 acgattgggt gagtttgtca aaaccttgaa aaatgtcgat aaatttgaag ttttgcctta
    32281 ccataccatg ggagaattca agtggcgtga gctaggtatt ccttatcagt tagaaggtgt
    32341 taaaccacca agtaaggaac gcgttcaaaa tgctaaaaat ctgatgcaga ccgaatctta
    32401 cacagaatat atgaatcgga ttcatcagtc ataagagctg ttatagggtt gaggtttcct
    32461 caacttttta aagtattata agcagatctt ttgtaatctt cctttgattt tagggggtaa
    32521 ttttgctaaa ataaaatgaa taaacaaaat gaggtagaat gattatgtca aaaattttag
    32581 tttttggtca tcaaaatcct gatacggatg ctattgcatc atcttatgct tttgattact
    32641 tatcccaaaa agcgtttggt ttggatactg aagtcgtagc tttaggaaca cctaacgaag
    32701 aaacagcttt tgcccttgat tattttggtg ttgaggcacc acgtgtggta gagtctgcta
    32761 aagcacaagg gtctgaacaa gtgattttga cagaccacaa tgaattccaa caatccattg
    32821 cagatatccg tgaggttgag gtatatggtg tggttgatca ccaccgtgtg gctaattttg
    32881 aaactgcaaa tcctttatac atgcgtgtgg aaccagtagg atcagcctca tctattgttt
    32941 accgtatgtt taaagaaaat ggcattgagg tgccaaaagc gattgcaggg atgctcttgt
    33001 ctggtttgat ttcagatacc ttgttgttga aatctccaac aactcatgtg tctgatcacc
    33061 ttgtcgctga agaattggca gagctagcag aagtgaactt ggaagactat ggaatggctc
    33121 ttttaaaagc aggtacaaac cttgcaagca aatcagaagt agaattgatt ggtattgatg
    33181 ccaaaacatt tgaattaaat ggcaatgctg tacgcgtggc acaagtgaac actgttgaca
    33241 ttgcagaagt cttagaacgt caagaagcta ttgaagcagc cattaaagat gccatggctg
    33301 cagaaggtta ttcagacttt gttttgatga tcacggatat tgttaactca aactctgaaa
    33361 ttctagctat tggagcaaac atggacaagg ttgaagcagc ctttaacttc acccttgaca
    33421 acaatcatgc cttcttagca ggtgccgttt ctcgtaaaaa acaagtggtt ccacaattga
    33481 cagaaagttt tggagcttaa tgaaaagacg ctttaaaagg acttggtttt tttgaccaag
    33541 tccttttttc actcttctat gctataatag aaggtatgat aacaatattt cattcagata
    33601 aactcaccag acaacctttc tttcaagacc ttatcaatta tctcgaccag catgatcacg
    33661 ttatattacg agagatcaaa aaagcctttc ctaatgtgac aggtattgac aaggccatcg
    33721 aaagctatgt ccaagctggc tatatttgcc gtgaaaataa gcgttatggc atcaatcttc
    33781 ctttggtgag ttctgatcag cagctggcct tagacactat gctttttgtg gacacctgtt
    33841 cagctatgta tgaaaatatt ttagcggttg tttttgagac tcatctaaca aaccaaacca
    33901 atcacgtgat gatcaaggaa aagaccaaca tcacgagaga cgatttgacc ctggctaatt
    33961 atttttaccg tctcaaaaga ggtgagaagc catcagctga gcagatggac ttgtatgacc
    34021 tcttggggga tgtgaatcag gaatatgccc ttaaatatat gacaactttt ttgcttaaat
    34081 tcacgcgcaa agaccttgtg atgcaaaaac gtcctgatat atttgtggaa gctctggtta
    34141 cacttggtta cctaaaacaa gtggagccta caacatacca gctgctaatg accttggata
    34201 aagaaagttt aacctttata gcgccataga aaaaagctag gaacaaggac tgttcttagc
    34261 tttttgagtg cttttatttt gtttttgcca ttaagtaaag aaaataaggg gctccgataa
    34321 gcgacactaa aatccctgtc tggatattac tgccaaccag atacactcgt ccgactgtgt
    34381 ctgcaacaag aagtaggatc attccgatta aaatgctaat gggtattgtt aatttatgat
    34441 tactccctac taagtatgta ctaaagtgtc cagctattaa gccgataaaa ctaatattac
    34501 caaccaaaag aacactcaaa gcacctaagc cagctgctaa gacaagtatc aaacgacgct
    34561 tacggtttaa agggagtcct agtccaatag cagtattatc agctaatccc ataatattaa
    34621 ggaaatgggc ttgactataa gtcaatagcc aaaaacacaa taataaagga gcgatgacac
    34681 tcagagtagg ccagtcgtct cctattaatt ggccgctaag ccaattgatg accaaatcga
    34741 ctttgtagtg attaatatga ccaacaagag caaccattag acttgaaagc atggtagtaa
    34801 cagctacacc agtaagaatt aaccgtgtag gatcaatttg tccttgtttt gtcaaagata
    34861 gccaataaac gctaaaggtt gttacaacag caccaagcat ggcaaataaa ggcaagtaat
    34921 ggctgatatg agcttgctca aagaaagaaa aggagaccac aatagccaaa gagatccctg
    34981 ctcctatagt aatacctaat acaccagagt cagctaaggg atttcgtgtt aaacgttgta
    35041 ataatagccc tgataaagca agagaaccgc ctcctagaca agcagctaga attcttggca
    35101 gacgaatgtt aataacgatg aaagatatgg catggctaga ttttcccaaa aacacatgga
    35161 caaagtccaa aaaagataga tgagattctc caagggacaa agctagtccc ataagactta
    35221 caagtagcag gatcaggcta gtatataacc ttaaaaggtg tctttgagat ttcaatagcg
    35281 gcctcctctt cttattaacc ataaaaagca tggaaaacca attaagctaa ccaatgcccc
    35341 aagaggggtt tcataaggcg gattgagatt acgacaagca atatcaaccc ataccatgaa
    35401 actagcgcca gaaactgcac aaagcggcaa aaggtatcgg taatgatgag gtgtaaagtg
    35461 tttcataaga tgaggaatga ctaagccgat aaaagaaatg cttccagcaa tggctacagc
    35521 tgctgatgat aaaataagaa ccaaaatcat aaagactgca ctgatcaagt tggtcttttg
    35581 cccaagagct tttgcctgag actcacttag actaaggacg gtcaggtgat aagataatag
    35641 ctgggctaaa caaagactaa gaataataag aggagcaata tagccgatca tttgccaatt
    35701 gaccccgaca agacctcctg cttgccagcc gataacagca tttgccagat gatagtaatt
    35761 ggtaatacct tgacctaatg ctgatagcag tatggaaacc atagctcctg ctaagacaag
    35821 gcggagctga tggtagcctt tgccagattg ataagaaagg ccaaagacta aggttgctgc
    35881 caggctagac cctaacaacg aaagcagaat aatgagggaa tagtgcaagt gaggtacaaa
    35941 cgcataagcc agtaccaagg ctagtcctgc tccagcatta atgcctaaaa ggccaggctc
    36001 agcgatagga ttacgtgtga ttgcttgcat gatagttcca gaaacagcta acgcagagcc
    36061 agttaaggta gcaccaaaaa gtctcggtaa tcgtatagct agtaaaacat tggctttatg
    36121 gccgttttgc tttccaaata aaatagagtt aagatcctga tgtgataaag caacggctcc
    36181 aaagcgcaga tgacagtaaa tagcaacaca taagctaaaa ctaagtagca caaagacaag
    36241 ccaaaagata tgtgacttag tgattatctg cgtttttttt aagcaaaaac gctcgagaca
    36301 caaaaaggga tgcttagttt tcacttgata agattgcctc tcgtaaagtc tctaattgat
    36361 attctaaaga aagaggatca gtaaagtaaa agacattggc attgactttg atcacatggt
    36421 gttttttcac agctggaatg gattgccata gcttgctttc atatagagca gaaccagtct
    36481 tatcatcttc tgcagcaacg acgacataat caccaatata gtctggcaag acttcctgcg
    36541 acaatgacag gtaaccttgt ttaaaaactt cagtcttcac tttttcagga gcatcataat
    36601 ggaaagcttg atggataacc tctccgccac gtccccagtc tttaccaaaa aggtaaacgt
    36661 ctttttcata aagccccata atagtaaagg ttgctttgtc acctgtaacg gccttgactt
    36721 ctttttcata agctgctgtt ttagttttcc aatcttttaa ccatttcttg gctttgcctt
    36781 ctttgttaaa gatgtggccg aagtcagata acacttgtaa ataatcacgt ttgcggtatt
    36841 caatcgaaat aacaggcgca atttctgcca attgtttaat attttcttct gtagagccaa
    36901 caacaatgag gtcaggctta agcgttgtaa tggcttctaa atcagttgca gcaacttgct
    36961 ttgctttttt tacagtcttt gctaagatgg ggtttttctt gtcataagaa gtaaccccga
    37021 ctagattcat atctaatttt ttgaggtaac cagtgtaagt tgaagccaga ctgactactc
    37081 gcttaggctg tttaggaata tctccgtaat aagtcacacc agcaatttga ggcataggcg
    37141 ataaactttt tgaggcggtg ttagaatgat tagttgcttg attaccacag gcgattaagg
    37201 tagtggttgt caaacagagt gttaatagta gagttaattt tttcatgtat gctaattctc
    37261 ctagaataaa gttattgaag ctgataagtc agcactatag gacagttgtg gataggatca
    37321 tcaaccagta ccggtttgat taggaagatg tcttgaatga taggtgaagt cataacatct
    37381 gctatagtac cagtataatg gatcttgcca tgtttcatag caatcagatg atccgaatag
    37441 cgggctgaaa gattgaggtc gtgaagaacc ataacaatag tcttgccggc atccttattt
    37501 agggatttaa cgagctctag gatttctagt tgatgattta aatctaaata agtagttggc
    37561 tcatctaaaa aaatagtatc agtgccttgg gctaatgcca ttgcaagcca aaccctttga
    37621 cgttgccccc cagaaagagc atcaacaggt tgatcagcat aggccatgac attggtggct
    37681 tgcatagccc aatgaatggc ttttttgtca gctggactaa gatttccaaa gtaagattga
    37741 tggggaaaac gtccgtaaga aaccaattcg taaacagtta tgccgttagt tgcttcttga
    37801 acttgaggta aaagagctag ttttttagca acctctttag tttctaatgt ggcaatgttt
    37861 tgcccattta aatacacaat tccctgtttt ggtggtaata atcttgtcag tgcttttaat
    37921 aaactagact tcccacagcc attggcgcca ataatggtcg taattttacc ttcaggaata
    37981 taaaacgata atttatcgat gatggtacgc tgtccatagg caattgtgag gtcttcagca
    38041 ctaattgttg tcatatggtt gcctcctttc taaaaagagt caaagggttg atgaaagtgc
    38101 acattaaagt gttcatctgc ccattttaaa atatttgaga agtagcttat tttctcaaaa
    38161 tcttcactat tatagcatag aaaaaaggct taacaaagcc cagattgaag acaaacatcg
    38221 atttggtgct tgtctttttt agtgttttta gataaaaatg gctgtttccg tgcttaaacc
    38281 acctcatctg aacaaaataa aaaggctctc ccgccatcct tttgaccagt tttttgagat
    38341 ttaagcatgc caaagtcagt ccaaccttat cttccatttt ggacttgcct ttctctctcg
    38401 tatagcggag attgtggtat tccttggctg tgccaaacag tcgttcaatc gtctctttcc
    38461 gatgctggta gagctccttc attccccttt gatgacgaat gtcctcgcac tgttccaaat
    38521 agtctttcca aatatgccgt gtgacaactt tttggtggtt cttactggtc gtacatacag
    38581 ataacagggg acaattggca caaattgcag ggtcactttt gtattctcgg tagccttctc
    38641 tggtcgtagt gcggtaggtc aaggcttgat gttcagggca aatgacacaa tcaaagtgct
    38701 catcataaat aaattcattc ggacgtagaa ggtctttctt tcctcttggt cgtgtgtaag
    38761 gaaggacagg agtgatctcc ttatcaatca gaaacttggc aatgctggga atgttatagc
    38821 cggaatccgc aataataaac tgtggtttca agggttcaag cttggcaaaa agtgcaggaa
    38881 aagcctgact atcatggata ttgccagcct caacactata agcaagcgcc catccatact
    38941 tgtcacaagc cacctgagca gaataagcga agacttcctt atgatcacct ttgtgaaacc
    39001 ag
//
LOCUS       DAUDWO010000017        36567 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.017, whole genome shotgun sequence.
ACCESSION   DAUDWO010000017 DAUDWO010000000
VERSION     DAUDWO010000017.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 36567)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 36567)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..36567
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.017"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(496..1672)
                     /locus_tag="VHC05_000829"
                     /pseudo
     CDS             complement(496..1672)
                     /locus_tag="VHC05_000829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612023.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            1977..2774
                     /locus_tag="VHC05_000830"
     CDS             1977..2774
                     /locus_tag="VHC05_000830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEQ5402153.1"
                     /translation="MIKLIATDMDGTFLAEDGTYNQEQLAALLPKLAEKGILFAVSSG
                     RSLLAIDQLFEPFLDQIAVIAENGSVVQYRGEILFADMMTKEQYTEVAKKILANPHYV
                     ETGMVFSGQKAAYILKGASEEYIQKTKHYYANVKVINGFEDMENDAIFKVSTNFTGHT
                     VLEGSDWLNQALPYATAVTTGFDSIDIILKEVNKGFGMEHLCQALGIKKAETIAFGDN
                     FNDYQMLEFAGRAIATENARPEIKVISDQVIGHCNDGAVLTYLKGLV"
     gene            2778..3602
                     /locus_tag="VHC05_000831"
     CDS             2778..3602
                     /locus_tag="VHC05_000831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEQ5402154.1"
                     /translation="MNIRILALDLDGTLYNTEKIVTDANKKALAAVREKGVKVVITTG
                     RPLKAIGNLLEELDLLDHDDYSITFNGGLVQRNTGEVLDKSSLSFDQVCQIQQALEAV
                     GLPTDIISGGDVYSIPSKDGRHSQYHLANPLLTFIEVTSVAELPKDITYNKIVTVTDP
                     DFLDQQIIKLSPSLFEDFEAFKSRDIIFEIMPKGIDKAFGLNLLCQHLGLDARHVMAM
                     GDEANDFAMLEWAGLGVAMANGVSGAKAVADAVTTLTNDESGVAEAVKTFILEEES"
     gene            3602..5152
                     /gene="ftsY"
                     /locus_tag="VHC05_000832"
     CDS             3602..5152
                     /gene="ftsY"
                     /locus_tag="VHC05_000832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HEQ5402155.1"
                     /translation="MGLFDRLFGKKETPKVAEEKLEENLLTETTQKEELSEKANEQDK
                     IEAVQQEDVSSEGAGSVENGPEAASVNAPVEEETGDNSNHPSEDTNKFAADKTDLKVS
                     ELSQSTASEPKDLVDQPVVEQFPTKQAQADASNDSANEEAVDTSKEQSSSQQVMEDYY
                     RRKAALEKSLQEKAAATVPVMPEEVPQENQASTSAEASQNKATYDTIPETDQEKYKRS
                     LKKTRTGFSARLNSFFANFRRVDEEFFEDLEEMLILSDVGVHVATTLTEELRYEAKLE
                     NAKKPDALKRVIVEKLVDIYEKDGRYNEAINYQDGLTVMLFVGVNGVGKTTSIGKLAY
                     RYKQEGKKVMLVAADTFRAGAVAQLVEWGRRVDVPVITGPEKADPASVVFDGMEKAVA
                     KGVDILLIDTAGRLQNKENLMAELEKMGRIIKRVLPDAPHETLLALDASTGQNALSQA
                     KEFSKITPLTGLILTKIDGTAKGGVVLAIRQELDIPVKFIGFGEKVDDIGEFHSEDFM
                     KGLLEGIL"
     gene            complement(5206..6573)
                     /locus_tag="VHC05_000833"
     CDS             complement(5206..6573)
                     /locus_tag="VHC05_000833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEQ5402156.1"
                     /translation="MSHHQQTVSKQTIMAIIAIALIGFSGILSETSMNVTFPTLMSVY
                     QLPLNSLQWMTTIYLLAVAIMMTTSATLKKNVRERPLFFMATGLFTFGTILAVLTQSF
                     AIMLLARIFQGIGTGLVMPQMFNIILERVPMHKVGLFMGFAGLIISLAPAFGPTYGGF
                     MISHFSWQWIFICILPVPLIAGILAYYYLEDSPVTEKVPFDWLAFIALSISLTSALLA
                     ITSLENGSVNLYYLELFILSFVLFLYKNLTAKQPFLDIRILKIPSLTFGLIPFFVFQL
                     INLGINFLTPNFIVMEKIANSSQAGMVLLPGTSLGALLAPAFGKLYDQKGARLSLYLG
                     NSLFSLSLIIMTLQTRHFMLLPFTLLYILFTFGRNMGFNNSLATAIRELPAEKNADAT
                     AIFQMMQQFAGALGTAMASLIANSQPEFTSGVQSVYLLFTIFALLDFIFFFAMFYHLG
                     KKGLA"
     gene            6901..7743
                     /locus_tag="VHC05_000834"
     CDS             6901..7743
                     /locus_tag="VHC05_000834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HEQ5402157.1"
                     /translation="MLIKRVLNHNAAISTNHQGLDILLMGKGIAFGKKVGDSIELNAI
                     ETSFVLKNSDNMNSFTELFITVPQEVVACSERIINLGKIKLGKTLDEILYINLTDHIH
                     SAIERHEQGMLIHNPLRWEIQRYYPDEYSLGVKALELIERNLGVTLAIDEAAFIAMHF
                     VNASLDTPFKEPHRLTEIVSYIEQKIKTDFKTELDDTSIDYYRFMTHIKLFAQRVLSE
                     MSYDDDDAELLLVVKTKYPKEYRCVLDISEEIKKRYNYHLNSSELLYLTVHVKRLVKH
                     LKET"
     gene            7745..9607
                     /locus_tag="VHC05_000835"
     CDS             7745..9607
                     /locus_tag="VHC05_000835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS beta-glucoside transporter subunit IIBCA"
                     /protein_id="HEQ5402158.1"
                     /translation="MTYQETAKAILAAVGGKTNIQRVTHCVTRLRLVLKNDEKVKDQQ
                     VKAISNVIGVMRKNGQYQIILGNDVNNYYQAFLSLGHFDNQDEDHSSKAKGSILERLI
                     ETIAGVITPLIPALLGGGMLKVVGILLTMLGLASADSQTVAFINFFGDAAYYFMPVMI
                     AYSAAARFKVTPILAATIAGILLHPAFVAMVAEGKPLALFGAPVTPASYGSSVIPILM
                     MVYLMQYIEKWVNRLVPSVMKSFLQPTLIILISGFLALVVVGPLGVIIGQGLSNTMLA
                     IYHVAPWLALAILGAIMPLVVMTGMHWAFAPIFLAASVATPDVLILPAMLASNLAQGA
                     ASLAVAFKTKQKQTRQVALAAGISALLAGITEPALYGVTLKFKKPLYAAMISGGLVGA
                     FIGFVNIASYTFVVPSIIGLPQYINPSGGANFTNALIAGAATIVLAFSLTWFMGIDEE
                     SPEQVSVAADMSQVKSGLSTKQTLYAPMTGEMLFLSEVPDETFSSKLLGEGFAILPSE
                     GVVYAPFDGEVITFFPTKHAVALKNTRGVEVLIHVGIDTVELKGQGFEQLVSVGDVVK
                     RGQALLKMDTDFITSKGYSLISPVVVTNSAEQLEIIIQDDKKMVTKEDALLVIL"
     gene            9626..11050
                     /locus_tag="VHC05_000836"
     CDS             9626..11050
                     /locus_tag="VHC05_000836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012766692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HEQ5402159.1"
                     /translation="MGIFSKDFLWGGAVAANQVEGAFEADEKGLSVQDVLPNGGLGEW
                     TDSPTSDNLTLEAIDFYHRYKEDIALFAEMGFKVFRTSIAWSRIFPNGDDDQPNEAGL
                     QFYDDLFDELLNYGIEPLVTLSHYETPLHLAKAYNGWTDRRLIGFFERFAQTVMERYK
                     DKVKYWLTFNEVNSILHMPFTSGGIMTEKEKLSLQDLYQAIHHELVASASVTKLAHEI
                     NPDVKVGCMILAMPAYPMTSDPRDILAAHAFENLNLLFSDIHVRGKYPSYIKSYFKEN
                     GIEIVFEDGDKELLAEHTVDFLSFSYYMSVTQAHNPEAYTSGQGNILGGLSNPYLESS
                     EWGWQIDPIGLRLVLNQYYDRYQIPLFIVENGLGAKDQLVQTADGSMTVHDDYRIDYM
                     SQHLVQVAKAIEDGVEVMGYTAWGCIDCVSMSTAQLSKRYGFIYVDRNDDGTGQLTRY
                     KKKSFDWYRQVIQTNGRYLEDNFS"
     gene            complement(11149..11964)
                     /locus_tag="VHC05_000837"
     CDS             complement(11149..11964)
                     /locus_tag="VHC05_000837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03943 family protein"
                     /protein_id="HEQ5402160.1"
                     /translation="MIRFLILSGYFELTMYLQLSGKLDQYINVRYSYLAYISMVLSFI
                     LALVQLYTWMKNIKVHSHLTGKIARLTSPFILVFPVLIGLLVPTVTLDSTTVSAKGYT
                     FPLAAGASKTGVSDDGTTIQYLKPDTSLYFTKSAYQKEMRQELHKYKGKKPVTITTEN
                     YMEVMELIYLYPDEFLDRDIQYTGFVYNEPGHDNYQFLFRFGIIHCIADSGVYGLLTT
                     GNQTSYPNNTWLTVKGRLHMEYDKNLEQHLPVLQLAEVHQTKEPNNPYVYRVF"
     gene            complement(11964..12866)
                     /locus_tag="VHC05_000838"
     CDS             complement(11964..12866)
                     /locus_tag="VHC05_000838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016480616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HEQ5402161.1"
                     /translation="MSLFSNLPPSVLQWFAIFMSIIIEALPFVLLGTILSGCIEVFVT
                     PELVQKYLPKQKCLRILFGTFVGFVFPSCECGIIPIINRFLEKKVPSYTAVPFLATAP
                     IINPIVLFATYSAFGNSLRFLILRLVGAALVAITLGVMLAFIVDDNILKDNAQPVHFH
                     DYSHESLPKRIYLALVHAIDEFFDTGRYLVFGTLIASAMQIYVPTRVLTTIGHNPLTA
                     ILIMMLMAFILSLCSEADAFIGASLLSTFGVAPVLAFLLIGPMVDIKNLMMMVKAFKG
                     RFIVQFIGVSVLMIAVYCLLVGVL"
     gene            complement(13014..13169)
                     /locus_tag="VHC05_000839"
     CDS             complement(13014..13169)
                     /locus_tag="VHC05_000839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402162.1"
                     /translation="MAITHKKNDELEKMLAGFASIPSFDKPLEVNTDGKLATKEKTTE
                     QTKPSKP"
     gene            13403..15535
                     /locus_tag="VHC05_000840"
     CDS             13403..15535
                     /locus_tag="VHC05_000840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding transcriptional accessory protein"
                     /protein_id="HEQ5402163.1"
                     /translation="MENNNNHNIAEALSVSLHQIEQVLALTAQGNTIPFIARYRKEVT
                     GNLDEVVIKSIIDMDKSLTTLNERKATILAKIEEQGKLTDQLRTSIEATEKLADLEEL
                     YLPYKEKRRTKATIAREAGLFPLARLILQNAQNLETAAEPFVTEGFASPQEALAGAVD
                     ILVEAMSEDAKLRSWTYNEIWQYSRLVSTLKDEQLDEKKVFQIYYDFSDQVSNMQGYR
                     TLALNRGEKLGILKVSFEHNLEKMQRFFSVRFKETNPYIEEVINQTIKKKIVPAMERR
                     VRSELSDAAEDGAIHLFSENLRHLLLVSPLKGKMVLGFDPAFRTGAKLAIVDQTGKLL
                     TTQVIYPVAPASQTKIQAAKETLTQLIETYQIDIIAIGNGTASRESEAFVADVLKDFP
                     NTSYVIVNESGASVYSASELARHEFPDLTVEKRSAISIARRLQDPLAELVKIDPKSIG
                     VGQYQHDVSQKKLSENLGFVVDTVVNQVGVNVNTASPSLLAHVSGLNKTISENIVKYR
                     EENGALTSRADIKKVPRLGAKAFEQAAGFLRIPGAKNILDNTGVHPESYPAVKELFKV
                     LGIQDLDDAAKATLAAVQVPQMAETLAIGQETLKDIIADLLKPGRDLRDDFEAPILRQ
                     DILDLKDLEIGQKLEGTVRNVVDFGAFVDIGVHEDGLIHISEMSKTFVNHPSQVVSVG
                     DLVTVWVSKIDLDRHKVNLSLLPPRDTH"
     gene            15522..15959
                     /locus_tag="VHC05_000841"
     CDS             15522..15959
                     /locus_tag="VHC05_000841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SprT family protein"
                     /protein_id="HEQ5402164.1"
                     /translation="MTLTNYVQEVSLADFGKPFHHKAYWNKRLKTTGGRFFPKDGHLD
                     FNPRMLEEHGELIFRKIVRHELCHYHLYFEGRGYHHKDRDFKDLLAQVNGLRYVPTSS
                     KSKTNHHYSCQTCGQVYQRKRRINLAKYVCGNCHGKLMEKNQS"
     gene            16023..16295
                     /locus_tag="VHC05_000842"
     CDS             16023..16295
                     /locus_tag="VHC05_000842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HEQ5402165.1"
                     /translation="METKFYKQRKNRLVAGVIAGLADKYGWDLALARVLAALLIYGTG
                     FGVLLYILLAIFLPYKEDLLEERYGRGPRRRKDADVLNEEEDGWFW"
     gene            16660..17592
                     /locus_tag="VHC05_000843"
     CDS             16660..17592
                     /locus_tag="VHC05_000843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012515957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr kinase/phosphorylase"
                     /protein_id="HEQ5402166.1"
                     /translation="MTVTVKMLVQKVKLDVVYATDNLLSKEITTSDISRPGLEMTGYF
                     DYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQAA
                     KEEGISLLSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKS
                     ETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGAS
                     AVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGRNVSVVIE
                     AAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ"
     gene            17589..18368
                     /locus_tag="VHC05_000844"
     CDS             17589..18368
                     /locus_tag="VHC05_000844"
                     /EC_number="2.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="HEQ5402167.1"
                     /translation="MINPIALKCGPLAIHWYALCILSGLVLAVYLASKEAPKKGISSD
                     AIFDFILIAFPLAIVGARIYYVIFEWSYYVKHLDEIIAIWNGGIAIYGGLITGALVLL
                     AYCYNKVLNPIHFLDIAAPSVMVAQAIGRWGNFINQEAYGKAVSQLNYLPSFIQKQMF
                     IEGSYRIPTFLYESFWNLLGFVIIMMWRRKPKSLLDGEIFAFYLIWYGSGRLVIEGMR
                     TDSLMFLGIRISQYVSALLIIIGLIFVIKRRRQKGISYYQE"
     gene            18390..18797
                     /locus_tag="VHC05_000845"
     CDS             18390..18797
                     /locus_tag="VHC05_000845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF948 domain-containing protein"
                     /protein_id="HEQ5402168.1"
                     /translation="MDLVGISLMIIALAFVALVIFLIIVLKKVSETIDEAKKTISVLT
                     SDVNVTLHQTNDILAKANILVEDVNGKVATIDPLFVAIADLSESLSDLNSQARHFGQK
                     ATNATGNVSKAGKLALVGKVASKVFGKKGEKHE"
     gene            18790..19218
                     /locus_tag="VHC05_000846"
     CDS             18790..19218
                     /locus_tag="VHC05_000846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HEQ5402169.1"
                     /translation="MNKSFKNLVIGAASGVAAAYFLSTEKGKALKNRAEKAYQAYKES
                     PDDYHQFAKEKGSEYSHLARDTFYDVKDKLASGDLTKEDMLDLLKDKTTAFVQKTKET
                     FAEVEAKEKQDDVIIDLNEEDIIIDYTEQDEPVSDTLDKH"
     gene            complement(19379..19663)
                     /locus_tag="VHC05_000847"
     CDS             complement(19379..19663)
                     /locus_tag="VHC05_000847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3270 domain-containing protein"
                     /protein_id="HEQ5402170.1"
                     /translation="MPAPLKKHNSVEQDDSYQESQSKFRDFQEFNGQSAKLKELVFFA
                     RIASFSLITVLFAFVLLVMNLAPMFAFLFASIISLGITSLLAKVIKSLLM"
     gene            19862..20788
                     /locus_tag="VHC05_000848"
     CDS             19862..20788
                     /locus_tag="VHC05_000848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HEQ5402171.1"
                     /translation="MEKIIITATAESIEQVKALLVAGVDRIYVGEANYGLRLPHNFSY
                     DELRQIAKLVHDAGKELTVACNALMHQDMMDQIKPFLDLMIEIAVDYLVVGDAGVFYV
                     NKRDGYNFKLIYDTSVFVTSSRQVNFWGQHGAVESVLAREIPSAELFTLAENLEFPAE
                     VLVYGASVIHHSKRPLLENYYHFTKIDDEVSRERGLFLAEPGDASSHYSIYEDNHGTH
                     IFINNDIDMMSKLGELYAHGLTHWKLDGIYCPGDDFVAITKLFIQAKTLLEAGQFTQE
                     EAEKLDQAVHAHHPAGRGLDTGFYEFDPKTVK"
     gene            20890..22176
                     /locus_tag="VHC05_000849"
     CDS             20890..22176
                     /locus_tag="VHC05_000849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HEQ5402172.1"
                     /translation="MSHMKKRPEVLSPAGTLEKLKVAIDYGADAVFVGGQAYGLRSRA
                     GNFSMEELQEGIDYAHARGAKVYVAANMVTHEGNEIGAGEWFRQLRDMGLDAVIVSDP
                     ALIVICSTEAPGLEIHLSTQASSTNYETFEFWKAMGLTRVVLAREVNMAELAEIRKRT
                     DVEIEAFVHGAMCISYSGRCVLSNHMSHRDANRGGCSQSCRWKYDLYDMPFGGERRSL
                     KGEIPEDYSMSSVDMCMIDHIPDLIENGVDSLKIEGRMKSIHYVSTVTNCYKAAVDAY
                     MESLEAFYAIKEELIDELWKVAQRELATGFYYGIPTENEQLFGARRKIPQYKFVGEVV
                     AFDSASMTATIRQRNVIMEGDRIECYGPGFRHFETVVKDLHDADGQKIDRAPNPMELL
                     TISLPREVKPGDMIRACKEGLVNLYQKDGTSKTVRA"
     gene            22381..22593
                     /locus_tag="VHC05_000850"
     CDS             22381..22593
                     /locus_tag="VHC05_000850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdbC family protein"
                     /protein_id="HEQ5402173.1"
                     /translation="MAEFTFKIEEHLLTLSENDKGWTKELNRVSFNGAEAKWDIRTWS
                     PDHTKMGKGITLTNEEFKTILDAFRK"
     gene            complement(22690..22830)
                     /locus_tag="VHC05_000851"
     CDS             complement(22690..22830)
                     /locus_tag="VHC05_000851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402174.1"
                     /translation="MTKEYISYISAAIFLLYGLLAAKWIFLGLGLILVLVGLADRLNS
                     KK"
     gene            complement(22966..24459)
                     /gene="lysS"
                     /locus_tag="VHC05_000852"
     CDS             complement(22966..24459)
                     /gene="lysS"
                     /locus_tag="VHC05_000852"
                     /EC_number="6.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014411828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysine--tRNA ligase"
                     /protein_id="HEQ5402175.1"
                     /translation="MSNQHIEELNDQQIVRREKMMALAEQGIDPFGKRFDRTANSAEL
                     KEKYADKTKEELHELNETAIVAGRLMTKRGKGKVGFAHLQDREGQIQLYVRKDSVGED
                     NYEIFKKADLGDFIGVEGEVMRTDMGELSIKATKLTHLSKSLRPLPEKFHGLTDIETI
                     YRKRHLDLISNRESFDRFVTRSKMISEIRRYLDGLDFLEVETPVLHNEAGGAAARPFV
                     THHNAQNIDMVLRIATELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQ
                     AYADYLDIMNLTEGIIQHAAKAVKGDGPIDYQGTEIRINEPFKRVHMVDAIKEVTGVD
                     FWPEMTVEEAIALAKEKQVPLEKHFTSVGHIINAFFEEFVEETLVQPTFVFGHPVEVS
                     PLAKKNPEDTRFTDRFELFIMTKEYANAFTELNDPIDQLSRFEAQAQAKELGDDEATG
                     IDYDFVEALEYGMPPTGGLGIGIDRLCMLLTNTTTIRDVLLFPTMKP"
     gene            24633..25535
                     /locus_tag="VHC05_000853"
     CDS             24633..25535
                     /locus_tag="VHC05_000853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000633099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEQ5402176.1"
                     /translation="MITAIVFDVDDTIYDQQAPYRIAMEKCFPDFDMSVMNQAYIRFR
                     HYSDVGFPRVMAGEWTTEYFRFWRCKETLLEFGYREIDEAAGVHFQEVYEHELENITM
                     LDEMRMTLDFLKSKNVPMGIITNGPTEHQLKKVRKLGLYDYIDPKRVIVSQATGFQKP
                     EKEIFNLAAEQFDMNPQTTLYVGDSYDNDIMGAFNGGWHSMWFNHRGRQLKPGTKPVY
                     DVAIDNFEQLFGAVKVLFDLPDNKFIFDVNDKKNPILQMGINNGLMMAAERLLESNMS
                     IDKVVILLRLTKQQEKVLRLKYAR"
     gene            complement(25643..26266)
                     /locus_tag="VHC05_000854"
     CDS             complement(25643..26266)
                     /locus_tag="VHC05_000854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEQ5402177.1"
                     /translation="MKLYFVRHGKTLWNLEGRFQGAGGDSPLLEEAKDEIHLLGKELA
                     KVAFDAVYTSDLQRAMATAAIILDAFDQQPKLYHTDQLREWRLGKLEGAKIATMAAIY
                     PQQMLAFRENLAQFKPDQFEAESIYQTTQRVCHLIQSFKDKHYQNVLIVGHGANLTAT
                     IRSLLGFEPALLLAKGGLDNASLTILETKDYLTYDCLIWNDKSFLEV"
     gene            complement(26342..26821)
                     /locus_tag="VHC05_000855"
     CDS             complement(26342..26821)
                     /locus_tag="VHC05_000855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA deacylase"
                     /protein_id="HEQ5402178.1"
                     /translation="MTKKTKLKKTLVEQILDKANIAHQGLKLNALEGDFPDDLQPSDI
                     YKTLALTGDQTGPLIGIIPLTEHLSEKQLAKVSGNKKVSMVPQKDLQKTTGYIHGANN
                     PVGIRQKHSYPIFIDQTALEKGQIIVSAGEVGRSIKISSQALADFVGASFADLKKRK"
     gene            complement(26914..27477)
                     /gene="thiT"
                     /locus_tag="VHC05_000856"
     CDS             complement(26914..27477)
                     /gene="thiT"
                     /locus_tag="VHC05_000856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupled thiamine transporter ThiT"
                     /protein_id="HEQ5402179.1"
                     /translation="MLPNTNVKYLIEAAIFAALAMTLSFIPDFAGWFSPSYGAIALVI
                     FSLRRGLKYGMLAGLIWGLLHFVLGKVYYLSMSQVFIEYILAFTSMGLAGSFSDSLIK
                     TLRRQQTFFAVFLAIMASLLAVTVRYLWHFLAGIIFWGSYAPKGMSAVWYSFSVNGTA
                     GVLTFLITCLALMIALPIHPQLFDPKD"
     regulatory      complement(27522..27618)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            complement(27745..28593)
                     /locus_tag="VHC05_000857"
     CDS             complement(27745..28593)
                     /locus_tag="VHC05_000857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 25 protein"
                     /protein_id="HEQ5402180.1"
                     /translation="MRRRIKPIVVLVFFILLAMVLIIGKRQANHAKQKEVEDAKSHIP
                     IATSNPSKAKTSTSETEDFILNPIVDVSGWQLPEEIDYDTLSRHISGAIVRVYGGSQI
                     TAHNNAAFTTGIDKSFKTHIKEFQKRNVPVAVYSYALGRSTKEMKEEARTFYKNAAPY
                     NPTYYWIDVEEATMKDMNKGVTAFREELKKLGAENVGLYIGTYFMAEQDISTKGFDAV
                     WIPTYGSDSGYYEAAPNTTLDYDLHQYTSQGYLSGFNNALDLNQIAVTKDTKKTFEKL
                     FGNSNN"
     gene            28918..29421
                     /locus_tag="VHC05_000858"
     CDS             28918..29421
                     /locus_tag="VHC05_000858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEQ5402181.1"
                     /translation="MSAKLMSRIAIMSALCVVLRMVFSSLPNVQPVTAFLLSYLLYFG
                     LAEAVLVMMLCLFLSAFLLGFGPWVFWQVTCFALVLLLWRFVLYPLSQQFPKYQLGCQ
                     AFLAALCGLLYGVLIDTCFAYLYSMPWWSYVLAGMPFNIAHALSTLVFFPVVMMLFRR
                     LIGEQKI"
     gene            29405..29788
                     /locus_tag="VHC05_000859"
     CDS             29405..29788
                     /locus_tag="VHC05_000859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4430 domain-containing protein"
                     /protein_id="HEQ5402182.1"
                     /translation="MNKRFKTGFLALVAMLLVACSQGTKQTQTPSVPKADHHVRLVVK
                     EDTNTIDEKVSFGKGDTVLEILKDNYEVKEKDGFITAIDGIEQDTKANKYWLFKVNGK
                     MADKGADQITVKDGDSIEFYQEVFK"
     gene            complement(29834..30313)
                     /locus_tag="VHC05_000860"
     CDS             complement(29834..30313)
                     /locus_tag="VHC05_000860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054718.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione peroxidase"
                     /protein_id="HEQ5402183.1"
                     /translation="MPNLYDFTVKAQNGNDLSLAAYKEKVVLIVNTATKCGLTPQYQA
                     LQALYDTYHDKGFEVLDFPCNQFLNQAPGDAEEINHFCSLTYHTTFPRFVKIKVNGKD
                     ADPLFAWLKEEKSGPLGKRIEWNFTKFLIDQNGQVIKRYSSKTDPKLIEEDLKALLG"
     gene            complement(30306..32105)
                     /gene="pepF"
                     /locus_tag="VHC05_000861"
     CDS             complement(30306..32105)
                     /gene="pepF"
                     /locus_tag="VHC05_000861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012766712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HEQ5402184.1"
                     /translation="MELKKRSEFPENELWDLTALYKDRQDFLLAIEKALQDIDLFKRN
                     YEGRLTSVDDFTQALIEIEHIYIQMSHIGTYAFMPQTTDFSDESFAQIAQAGDDFMTK
                     ASVALSFFDTALANADLDVLDTLEKNPYFSAAIRMAKIQKEHLLSPDVEKALANLREV
                     INAPYDIYTKMRAGDFDMEDFEVDGKTYKNSFVSYENFYQNHENAEIREKAFRSFSKG
                     LRKHQNTAAAAYLAKVKSEKLLADMKGYASVFDYLLAEQEVDRSLFDRQIDLIMTEFG
                     PVAQKFLKHVAQVNGLEKMTFADWKLDIDNDLNPEVSIDGAYDLVMKSLAPLGQEYTK
                     EIERYQTERWVDFAANANKDSGGYAADPYKVHPYVLMSWTGRMSDVYTLIHEIGHSGQ
                     FIFSDNHQSYFNTHMSTYYVEAPSTFNELMLSDYLEHQFDDPRQKRFALAHRLTDTYF
                     HNFITHLLEAAFQRKVYTLIEEGGTFGADQLNAMMKEVLTDFWGDAVDIDDDAALTWM
                     RQAHYYMGLYSYTYSAGLVMSTAGYLNLKNNPDGAKEWLDFLKSGGSRTPLDTAMLIG
                     ADIATEKPLRDTIQFLSDTVDQIINYTEEMSHA"
     gene            32264..35062
                     /gene="ppc"
                     /locus_tag="VHC05_000862"
     CDS             32264..35062
                     /gene="ppc"
                     /locus_tag="VHC05_000862"
                     /EC_number="4.1.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate carboxylase"
                     /protein_id="HEQ5402185.1"
                     /translation="MIEETSKEGDGHLPLKKLESSNNQTIIAEEVALLKEMLENITRR
                     MIGDDAFTVIESIMVLSEKQDYIELEKVVANISNQEMEVISRYFSILPLLINISEDVD
                     LAYEINHQNNTDTDYLGKLALTIKDLAGKDNGKDILEQVNVVPVLTAHPTQVQRKTIL
                     ELTTHIHKLLRKYRDAKTGVINLEKWRQELYRYIEMIMQTDIIREKKLQVKNEIKNVM
                     QYYDGSLIQAVTKLTTEYKNLAQKHGLELDNPKPITMGMWIGGDRDGNPFVTAETLCL
                     SATVQSEVILNYYIDKLAALYRTFSLSSTLVQPNSEVERLASLSQDQSIYRGNEPYRR
                     AFHYIQSRLKQTQIQLTNQPAARMSSSVGLNTSAWSSPASLENPILAYDSPVDFKADL
                     KAIEQSLLDNGNFALIEGDLREVMQAVDIFGFFLASIDMRQDSSVQEACVAELLKGAN
                     IVDDYSSLSETEKCDVLLQQLMEEPRTLSSAAVAKSDLLEKELAIYTTARELKDKLGE
                     EVIKQHIISHTESVSDMFELAIMLKEVGLVDQQRARVQIVPLFETIEDLDNARDIMAA
                     YLSHDIVKSWIATNRNYQEIMLGYSDSNKDGGYLASGWTLYKAQNELTAIGEEHGVKI
                     TFFHGRGGTVGRGGGPSYDAITSQPFGSIKDRIRLTEQGEIIENKYGNKDVAYYHLEM
                     LISASINRMVTQMITDPNEIDSFREIMDSIVADSNTIYRKLVFDNPHFYDYFFEASPI
                     KEVSSLNIGSRPAARKTITEITGLRAIPWVFSWSQNRIMFPGWYGVGSAFKRYIDRAQ
                     GNLERLQHMYQTWPFFHSLLSNVDMVLSKSNMNIAFQYAQLAESQDVRDVFYEILDEW
                     QLTKNVILAIQDHDDLLEDNPSLKHSLKSRLPYFNVLNYIQIELIKRWRNNQLDENDE
                     KLIHTTINGIATGLRNSG"
     gene            35202..36506
                     /locus_tag="VHC05_000863"
     CDS             35202..36506
                     /locus_tag="VHC05_000863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011527521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HEQ5402186.1"
                     /translation="MIISRSRGKTMKIDKRHLLNYSILLPYLILSVIGLIMVYSTTSV
                     SLIQAHANPFKSVINQGVFWIISLVAITFIYKLKLNFLTNTRVLTVVMLGEAFLLIIA
                     RFFTTAIKGAHGWIVIGPVSFQPAEYLKIIMVWYLALTFAKIQKNISLYDYQALTRRK
                     WWPTQWNDLRDWRVYSLLMVLLVAAQPDLGNASIIVLTAIIMFSISGIGYRWFSAILV
                     MITGLSTVFLGTIAVIGVERVAKIPVFGYVAKRFSAFFNPFHDLTDSGHQLANSYYAM
                     SNGGWFGQGLGNSIEKRGYLPEAQTDFVFSVVIEELGLIGAGFILALVFFLILRIMNV
                     GIKAKNPFNAMMALGVGGMMLMQVFVNIGGISGLIPSTGVTFPFLSQGGNSLLVLSVA
                     VGFVLNIDASEKRDDIFKEAELSYRKDTRKENSKVVNIKQFQ"
BASE COUNT        11217 a         6516 c         7771 g        11063 t
ORIGIN      
        1 ttattgaatt ttgattatat tcgagacatc attatattat tgttcgatta gatggaagta
       61 tggaatacag attttcatct gtagctttaa aaaataaaat taaaagcata cttgatagtt
      121 gatgtatact gtcatttaga ataataatca catattgttg tcaacgaagc ccaccatagc
      181 ctataatgaa agcctagtag ggatgagcta tataccaact atctatcaat ccagacgtct
      241 ctactaaaaa atactccgtc ttctatgaaa ctagaaacgg agtatttctg tttgtctata
      301 ccactaaatg aacagttata tagaaaggtg attggatgtt tggaataaac atcatgaaaa
      361 aaatttgaga ccttcttata tcctaaacta gaacgaatgt ctagtgaaat aaaaaaaaac
      421 gacaccatta ggatgtatat tttggactaa tgtcaaataa gtagacagaa aaccgtgtta
      481 ttttattgcg ttaaactaat tttcttcttt ctgattaggg gttagtccta gattagccgt
      541 atgtgggttg taattgttat aaaaattctc aatgtattca aagcaatcta attgaacctg
      601 tttgatattt tgatactttt ttcggttgat ttgtctatgc tttaaatact tgaaaaatgc
      661 ttcagttacg gcattatcat aaggatatcc aggtttagaa aaagaatgca tgatagtgtt
      721 gtcatcaatt atttttctca attccctggc cttaaattgt gacccttggt cggaatgaaa
      781 gagaagtgtt ccttcaatct ttcttttatt aagagctaat tctagagtgt cacatgctaa
      841 ctttgcatcc atatgatgac tcagtttcca agcaatacat tttctagaat agagatcaag
      901 tattgcgcag agatagacat atttcttata tccaatagaa tagagatcaa gtattgcgca
      961 gagatagaca tatttcttat atccaataga aatataggtg aagtcagtag accatacttg
     1021 atttggtttg tcaggattaa atttctggtt gagtaagttt tgaggatacg ttttttgagt
     1081 ccttttaaga gctgtttttg gcttaacggt agccatttta ggaagcccat attcttcatc
     1141 agacggtaaa ttcttccttc agagattttt gtgtcgtagt ctctttgaag aatgactttg
     1201 atagacttca caccaagtct tttgttcgct ttggtataaa tctcaagtat ttgtttttta
     1261 taaatttgat tatccaattc tcttttggag ggcttatgtt ttagaaattt atagtaagtg
     1321 gagcgattga cacgtaaaac acgatacaag gttgttgtgg cgtgttcaaa gcgtaaccga
     1381 tagacagcga ggagtcttac tttaagtttt gcatgaatat ggcacttgct ttttttagga
     1441 taaggttctc ctcttcaagc tgcgcattac gtttttgtag ctcttgtatt tgcttggcag
     1501 taagtacaga attatcttcg agtttgactt gagaatactg tttgatccat tttgcaagcg
     1561 cagaagcgga taccccatag tctttacaga gttcagactg agtttttcca gtttgataaa
     1621 ggttgacaag agattgtttg aattcttcat cgtagcgttt aactgttgac ataggttgtc
     1681 ctttcgtttt tgtgtctttt aaaacagatt gtaacacaca aagttttgtc tacttttata
     1741 gtatacatcc agtggtcatt tataaaaata aaaaaagtag cagttcactt caaaaacggt
     1801 caggttatcg aaatataatc tggctgtttt ttacgaatgg aatgaaagct gctttttatg
     1861 atataataag aaaaattgaa cagaatgcag aaatgatggg gcttatttaa atcgttaaaa
     1921 agtgcacacc ctaaatggcg tttgcacccc cctagagtaa aaaaaggaga cattgtatga
     1981 taaaactaat agcaacagat atggatggta ccttcctagc tgaagatggt acttataatc
     2041 aagagcaact agctgcgctc ttgccaaagt tagccgaaaa aggcatttta tttgcggttt
     2101 cgagtggccg ctcgctctta gccattgatc agctctttga gccctttttg gatcagattg
     2161 ctgttattgc agaaaatggt tccgtggttc aataccgtgg tgagattcta tttgcagata
     2221 tgatgaccaa agagcagtat accgaagttg caaaaaagat tttagccaat cctcactatg
     2281 tagaaacagg tatggttttt tctgggcaaa aggcagccta tattttaaaa ggcgcatcag
     2341 aagagtacat tcaaaaaaca aaacattact atgctaatgt taaggttatt aatggttttg
     2401 aagatatgga gaatgacgcc atttttaaag tttctaccaa cttcacaggc cataccgtct
     2461 tagaaggaag cgattggttg aatcaagccc tcccttatgc cactgcagtg accaccggct
     2521 ttgattccat tgatattatc ttaaaagagg tgaataaggg ctttggtatg gagcatcttt
     2581 gtcaagcctt gggcattaag aaagcagaaa cgattgcttt tggggataat tttaatgatt
     2641 accagatgtt ggagtttgct ggtagggcta ttgctacgga aaatgcaaga cctgaaatca
     2701 aagtgatttc agaccaagtc attggccact gtaatgacgg agcagtacta acgtatttaa
     2761 aaggactagt gtaactcatg aatattagaa ttttggcgct tgatttagac ggtaccctct
     2821 acaacactga aaaaattgtc acagatgcca ataaaaaagc cttagcagcg gttagagaaa
     2881 aaggggttaa ggtggttatt accacaggtc gccctctaaa ggccatcggt aacttgctag
     2941 aagagttgga cttgcttgac cacgatgact acagtattac ctttaatggg ggtttggttc
     3001 agcgaaatac aggggaggtt ttggataaga gctctctcag ttttgaccag gtttgccaga
     3061 ttcagcaagc tttagaggcg gttggcttac caacagatat tatcagtggt ggggatgtgt
     3121 atagcattcc aagtaaggac ggtaggcatt cgcagtacca tctagctaac ccactgttga
     3181 cctttattga ggtgacatct gtagcggaac taccaaaaga cattacctat aacaaaattg
     3241 tgacagtcac cgatccagac tttttggatc agcagattat aaagctatcc ccaagcttat
     3301 ttgaggattt tgaagccttt aaatcacgag atattatttt tgaaatcatg ccaaaaggca
     3361 ttgataaagc ttttggatta aacttgcttt gccagcacct tggccttgac gctagacatg
     3421 tcatggctat gggagacgaa gctaacgact ttgcgatgtt agaatgggca ggacttggag
     3481 tagctatggc taatggtgtt tcaggagcta aagccgttgc cgatgccgtg accaccttga
     3541 ccaatgatga gtctggagtt gcagaagctg tgaagacatt tattttagaa gaggagagtt
     3601 aatgggatta tttgatcgtt tatttgggaa aaaagaaacc ccgaaggtag ctgaggaaaa
     3661 gttagaagaa aatcttttga cagaaacaac tcagaaagag gagctttctg aaaaagccaa
     3721 tgagcaagac aagattgagg cggttcaaca agaggacgtt tcttcagagg gcgcaggttc
     3781 ggtggaaaat ggtcccgaag cagcttcagt aaacgcaccg gttgaggaag aaacaggtga
     3841 caatagtaat catccatcag aagataccaa taagtttgct gccgacaaaa cagaccttaa
     3901 ggtaagtgaa cttagtcaat ctacggcatc agaaccaaaa gaccttgttg accagccagt
     3961 tgtggaacag tttccaacaa aacaagccca agctgatgcc tcaaatgatt cggcgaatga
     4021 agaagcagta gacacttcaa aagagcaatc cagtagccaa caggttatgg aagactacta
     4081 tcgtcgtaag gctgctcttg aaaaaagtct tcaagaaaaa gcagcggcaa cggttccagt
     4141 gatgccagaa gaggttccac aagaaaatca ggcctctacc tcagcagaag cttctcaaaa
     4201 caaggcaacc tacgatacca ttcctgagac agatcaagaa aaatacaagc gtagcttgaa
     4261 aaaaacgcgg actggcttct cagctcgtct gaacagtttc tttgccaatt tcaggcgagt
     4321 ggatgaagaa ttctttgaag acttggaaga aatgctgatc ttatcagatg tcggtgtaca
     4381 tgtggcgaca actttgacag aggagttgcg ttatgaagcc aaactggaaa atgcgaaaaa
     4441 accagatgcc ttgaaacgtg tgattgtgga aaaattggta gatatctatg aaaaagatgg
     4501 gcgttataat gaagccatta attatcaaga tggattgacg gttatgcttt ttgtaggtgt
     4561 taacggggtt ggtaaaacga cttcaatcgg gaagctggct taccgttaca aacaagaagg
     4621 taaaaaagtc atgttggtgg cagcagatac cttccgagca ggggctgtgg ctcagctagt
     4681 cgaatgggga cgccgagtag atgtgccagt cattactggc cctgaaaagg ctgatccagc
     4741 gtctgttgtt tttgacggga tggaaaaagc tgtggcaaaa ggtgtagata ttctcctgat
     4801 tgacacggct ggtcgcctgc agaacaaaga aaatctcatg gcagagctgg aaaaaatggg
     4861 tcgtatcatt aagcgcgtgc taccagatgc ccctcatgaa acgcttttgg ccttagatgc
     4921 gtcaacaggt caaaatgcgc ttagccaagc caaggaattt tcaaaaataa cacctttaac
     4981 aggcttaatt ttaacgaaaa ttgatgggac tgcaaaaggt ggggtggtcc tagccatccg
     5041 tcaagaatta gacattccag tcaagtttat cggatttggt gaaaaagtgg atgatattgg
     5101 agaattccac tcagaagact ttatgaaagg tcttttagaa ggtattttat aagaaaaaaa
     5161 ccagtcttgt tcaacagaac gaggctggtt tttaagtaag tcagcttagg ctaatccttt
     5221 tttccctaaa tggtaaaaca tagcaaagaa aaagataaaa tcaagtagag caaaaatagt
     5281 aaagagaagg tagacagact ggacaccgct tgtgaattct ggctgactat tggctatcag
     5341 tgatgccata gcagttccta gagcgccagc aaattgctgc atcatctgaa aaatggccgt
     5401 ggcatcggca tttttctcgg caggcaattc tcgaatagcc gtggctaagc tattattaaa
     5461 gcccatgtta cgcccaaacg tgaataaaat atataaaaga gtgaatggta aaagcataaa
     5521 atgtcttgtt tgaagtgtca taataatcaa tgataaacta aataaggaat ttcctaaata
     5581 aagcgaaagt cttgctcctt tttgatcata aagtttacca aaagcaggtg ctagtagagc
     5641 tccgagtgag gtaccaggta gtaacaccat accagcttga gaactattag caatcttttc
     5701 catgacaata aagtttggcg ttagaaaatt tatgcctaaa ttaatcagct ggaagacaaa
     5761 aaagggaatc aggccaaagg ttagagaggg aattttgaga atgcgaatat caagaaaggg
     5821 ttgcttagct gtgagattct tgtagaggaa gaggacaaag ctgagaataa aaagctctaa
     5881 gtaatacaaa ttaacacttc cgttttctag actagtaata gctaataagg cagaagttaa
     5941 gctaatcgat agtgcaataa atgccaacca gtcaaagggt actttttcgg ttactggaga
     6001 atcttcgagg taataataag ctagaatacc tgcaatcagt ggtacaggga gtatacagat
     6061 aaaaatccat tgccaactaa aatggctaat cataaagccc ccataagtag gcccaaaagc
     6121 aggtgctaag ctaataataa gaccagcaaa tcccataaat agacctacct tatgcattgg
     6181 gacacgctct aaaataatat taaacatctg aggcattacc agaccagtac caatgccttg
     6241 aaaaatgcgg gctagcaaca tgatcgcaaa ggactgggtc agaacggcca agatggtgcc
     6301 aaatgtaaaa agacctgtgg ccataaaaaa gaggggtctt tcccgcacat tttttttcag
     6361 tgtagccgaa gtggtcatca taatcgccac tgctagtaaa taaatggtcg tcatccattg
     6421 caagctattt aagggcaact gatagactga catcagtgtc gggaaggtga cattcatact
     6481 ggtttcagac aaaattcctg aaaaaccaat gagtgctatg gcgataatcg ccataattgt
     6541 ttgttttgaa acggtttgtt gatgatgtga catgataact cctttatcta atcgattgtt
     6601 attgtatcat ataatcttaa aattgtcaga aactcttttt tgctaaatca atagatacga
     6661 ataacaatag ttgctctttc agagaatttt ttgaaaacgc ttgacagaat cttaaagaga
     6721 tgataacatt aaagcgttct cagatgtgat tacttcaggt aagcaggcta gagacataac
     6781 aatcagaata ttaaaggatg ttatcacagt tttgtgagca gggacctatt cgaaaagtgc
     6841 tttttagcga gcttttggat aggtcatttt ttattgtgat actaaaggac taggactttt
     6901 atgttgatta aacgcgtttt aaaccataat gcggcgattt cgaccaacca tcaaggatta
     6961 gatattttat tgatgggaaa agggattgcc tttggaaaaa aagttggaga tagtattgag
     7021 cttaatgcta tcgaaacatc atttgtttta aaaaatagtg acaatatgaa tagcttcaca
     7081 gagttattta ttacggtgcc acaagaagtt gttgcttgct cagagagaat tatcaatcta
     7141 ggtaaaatta aattaggcaa aaccttagat gaaattctct atattaattt aacggatcat
     7201 attcactctg ctattgaaag gcatgagcaa ggaatgttga ttcataaccc actacggtgg
     7261 gaaattcaac gctattatcc tgatgaatat agtctagggg taaaagcctt agagctaatt
     7321 gagcgtaatc taggagtcac tctagctatt gatgaagcag cttttattgc catgcatttt
     7381 gtcaatgcta gtttggacac tccttttaag gagccacatc gcctgacgga gattgtttct
     7441 tatattgagc aaaaaatcaa aacagacttc aaaacagaat tggatgacac atccatcgat
     7501 tattaccgct ttatgaccca tattaaatta tttgctcaac gtgtgttatc cgagatgtct
     7561 tacgatgatg atgatgcgga actgctttta gtggtgaaaa cgaaataccc taaagaatac
     7621 cggtgcgtct tagatattag tgaggagata aaaaagcggt acaactacca ccttaattca
     7681 agcgaacttt tgtatttgac ggttcatgtt aaacgtttag tgaaacattt aaaggagact
     7741 taatatgacg tatcaagaaa ctgccaaggc tattttagcg gcggttggtg gcaaaacaaa
     7801 tattcaacgt gtgacacact gtgtaacacg tctacgctta gtactgaaaa atgatgagaa
     7861 agttaaagat cagcaagtca aagccatttc aaatgtgatt ggtgtgatgc gcaaaaacgg
     7921 ccagtaccaa attatcttgg gcaatgatgt caataattat taccaagcct ttttaagcct
     7981 agggcatttt gacaatcaag atgaagatca ttcttcaaaa gcgaaaggaa gtatccttga
     8041 gcgcttgatt gaaaccattg ctggcgtgat tacaccgctg attccagccc ttcttggtgg
     8101 tggaatgctc aaagtggtgg gaatcttgct tactatgctt ggcttagcga gtgcggactc
     8161 tcaaaccgtt gcctttatta acttctttgg cgatgcggct tattatttta tgcctgtcat
     8221 gattgcctat tcagcagcgg cgcgctttaa ggtgacacct attttagcag cgacgatcgc
     8281 agggatttta ttgcatcctg cctttgttgc aatggtagca gaaggtaaac cattggcttt
     8341 atttggagca ccagtcactc ctgctagcta tggctcatct gttattccca ttttgatgat
     8401 ggtttacttg atgcaataca ttgaaaaatg ggtcaatcgc ttggtgccaa gcgtgatgaa
     8461 aagcttctta cagccaacct taatcatttt gatttctggc tttttggctt tagtggttgt
     8521 aggtcctctt ggtgtgatta ttggtcaagg gttatctaat accatgctcg ctatttatca
     8581 tgtggctccg tggctagcac ttgccatttt gggagcgatt atgccgcttg ttgtcatgac
     8641 ggggatgcac tgggcttttg caccaatctt tttggccgct tcggtcgcaa caccagatgt
     8701 cttgatttta ccagcaatgt tggcttctaa tttggctcaa ggagccgcat ctttggctgt
     8761 tgcctttaaa acaaagcaga aacaaacacg tcaagttgcc cttgccgcgg ggatttcagc
     8821 tttgctggca ggtatcacgg aaccggcact ttatggggtc acactgaaat ttaaaaagcc
     8881 actctatgca gccatgattt caggtggtct ggtcggagcc tttattggtt ttgtcaatat
     8941 tgcttcttat acctttgtcg taccttctat tattggttta ccacagtaca tcaacccatc
     9001 aggcggagct aattttacaa atgctttgat tgccggagct gcgacgattg tgttagcctt
     9061 cagtttgact tggttcatgg gaattgatga agaatcccca gagcaagtga gtgttgcagc
     9121 agatatgtca caagttaaga gcggcttgtc aaccaaacaa acgttgtatg ctccaatgac
     9181 aggtgagatg ctttttctat cagaagttcc tgatgaaacc ttttcttcca agttattagg
     9241 agaaggattt gccatattac caagcgaagg tgtggtctat gccccctttg atggtgaagt
     9301 catcactttc tttccaacca agcatgctgt tgccttaaaa aacacacgtg gtgtggaagt
     9361 cttgattcat gtcggtattg atacggttga gttaaaaggg caaggtttcg agcagttagt
     9421 gtctgttggc gatgtcgtga aacgaggcca ggcacttcta aaaatggata ctgatttcat
     9481 tacttcaaaa ggctattcac tcatcagtcc tgtggtcgtg accaattcgg ctgagcagtt
     9541 ggagattatt attcaagatg acaaaaaaat ggtgactaaa gaggacgctt tgttagtcat
     9601 tttataacct aaaaggagag ggagaatggg aattttttca aaagatttct tatggggcgg
     9661 cgcagtagct gccaaccaag tggaaggagc atttgaggca gacgaaaaag gtttgtccgt
     9721 acaagatgtt ctaccaaatg gtggactagg agaatggaca gatagtccta ccagcgataa
     9781 tttaacttta gaggcgattg atttttacca ccgctacaaa gaagacattg ctctttttgc
     9841 cgagatgggc tttaaagtct ttcgaacgtc tattgcttgg tctcgtattt ttccaaatgg
     9901 tgacgatgac cagcccaatg aagcaggttt gcaattttat gatgacttat tcgatgaatt
     9961 gttgaactat ggtatcgaac ccttagtgac cttgtcgcat tatgagacac ctctgcattt
    10021 ggccaaagcc tataatggtt ggacagatag acgtctgatt ggcttttttg agcgctttgc
    10081 tcagacagtc atggaacgct ataaggacaa agtcaaatac tggttgacct tcaacgaagt
    10141 caactcgatt ttacacatgc cctttaccag tggtggcatc atgacagaaa aagaaaagct
    10201 gagcctgcaa gatttatacc aagctattca tcatgaattg gtagcatctg ctagtgtcac
    10261 aaagctagcg catgaaatca atcctgatgt taaagttggg tgtatgattt tggcgatgcc
    10321 tgcttaccca atgacctctg atcctcgtga tatacttgct gcgcatgcat ttgaaaatct
    10381 taatctctta ttttcagata ttcatgtgag aggcaagtat ccttcatata ttaagtcgta
    10441 ttttaaagaa aatgggattg agattgtttt tgaagacgga gacaaggaat tattagcgga
    10501 acatacggtt gattttctat cctttagcta ttacatgagt gtcacacaag cccacaatcc
    10561 tgaagcttac acatctggtc agggaaatat tctaggtggt ttgtccaatc catatttaga
    10621 atcttcggag tggggttggc agatagaccc aattggtctg cgattggtct tgaatcagta
    10681 ctatgaccgc taccagattc ctttgtttat tgttgaaaat ggcttaggtg caaaggatca
    10741 gctggtgcaa accgcagatg gcagcatgac ggttcacgat gattatcgca ttgactacat
    10801 gagtcagcat ctcgtacaag ttgccaaagc gattgaagat ggcgttgagg tcatgggtta
    10861 cactgcttgg ggctgtattg attgtgtctc tatgtcaaca gcccaattaa gtaagcgcta
    10921 cggttttatt tatgttgacc gaaatgatga tggtactggt caactcacac gctataagaa
    10981 aaaatcattt gattggtacc gacaagtcat tcaaaccaat ggacgttacc ttgaggataa
    11041 tttttcctaa ataggtcttg tttaagatgg tgactctgtt cctatgctaa ctgataaaac
    11101 tcaaaaagca tttgttttga taaaaaacaa gtgctttttt attagtcttt aaaaaacgcg
    11161 gtaaacataa ggattattag gttctttggt ttgatgaacc tcagcaagtt gaaggacagg
    11221 tagatgttgt tctaagtttt tatcatattc catatgaagg cgacctttaa ctgttagcca
    11281 tgtgttgtta gggtagctgg tttgattacc tgtggtcaaa agtccgtaca ctcctgagtc
    11341 ggcaatacag tgaataatgc cgaagcggaa aaggaattgg tagttgtcat ggcccggttc
    11401 gttataaaca aagccagtgt attggatgtc acgatcaaga aactcatctg ggtagagata
    11461 gatcaattcc atcacttcca tataattttc agtggtaatg gtgaccggtt tcttgccttt
    11521 atatttatgg agttcttgac gcatctcctt ttggtaggca gactttgtaa agtaaaggct
    11581 ggtatcaggt ttgaggtatt gaatggtggt accgtcatca ctgactcccg ttttagaggc
    11641 tcccgcagcc aatgggaaag tatagccttt agcagaaacc gtggtggaat ctaaggtcac
    11701 ggtcggcaca aggagaccaa tcaaaacagg aaagaccaag ataaaaggac tggtcagcct
    11761 tgcgattttt cctgttaaat ggctatgtac cttaatgttt ttcatccagg tatagagttg
    11821 aacaagagct aaaatgaaag ataaaaccat ggaaatataa gcaaggtaag aataccgaac
    11881 attgatgtac tgatccagtt tgccagacag ctggagatac atggttagtt caaaatagcc
    11941 agataaaatt aaaaagcgaa tcattagagc acccccacaa gtaaacaata aacggcaatc
    12001 ataagaacgg atacgccgat aaattggaca atgaagcgtc ctttaaaagc ctttaccatc
    12061 atcataaggt ttttaatatc caccatagga ccaattaaaa gaaaggcaag aactggagcc
    12121 actccaaagg tggataataa ggaagctccg ataaaggcat cggcttcact acataatgat
    12181 agaatgaaag ccatcagcat catgatcaaa atggctgtca agggattgtg cccaatcgtt
    12241 gtcaacacac gagttgggac atatatttgc attgcagagg caatcaaggt tccaaatacg
    12301 agatacctgc cggtgtcgaa gaattcatca atagcatgta ccagtgctag ataaatgcgt
    12361 tttggcaagc tttcatgaga ataatcatga aaatgcacgg gttgagcatt atccttgaga
    12421 atgttatcat ctacaataaa agctaacatt accccaagtg taatggctac tagtgcagca
    12481 ccgaccaagc gaagtatcag aaagcgcaaa gaattcccaa aagcagaata agtagcgaac
    12541 aaaacaatag gattaataat aggcgctgtt gccagaaaag ggacggccgt ataactaggc
    12601 accttttttt ccaaaaagcg gttgatgatg ggaataatcc cgcattcaca agaaggaaaa
    12661 acaaatccaa caaaggttcc aaacagaatg cgcaagcatt tttgcttagg taggtatttt
    12721 tgaaccaatt ctggcgttac aaagacttca atacaaccag ataaaatagt tcctaggagc
    12781 acaaaaggaa gagcttcaat gataatggac ataaaaatcg caaaccattg caagacactg
    12841 ggaggaaggt tggaaaagag tgacattcac catatccttt ctagatgata aaagaggagg
    12901 ctgaaacacg aatgttcagc ctcgactgat acgttttgtt agcctgatcg ctaaaaatct
    12961 ctcaactcag tttaaacgaa tggacgatat gttaagagaa tgagacaaac tagctatggt
    13021 ttgcttggtt ttgtttgttc tgtcgttttt tctttggtcg ctagtttacc atcagtattg
    13081 acttccaaag gcttatcaaa actagggatt gatgcaaagc ctgctagcat tttttcaagt
    13141 tcatcatttt ttttatgggt aattgccata tctatgacct tctttcattc aagataagtc
    13201 tattatacta tcatttgaga acaatgccaa agcggaagtg ttgtttacct ctttcttttt
    13261 taaaattagg tattgttatt tagggtttcg tcagttattt actaaaagta gctttttttg
    13321 attctttacg caactttata ttaggacaat gtttcgctat cattttttgc attaacatgg
    13381 tttgtgttat aatagcaata ttatggaaaa taacaataat cacaacattg cagaggcttt
    13441 gtcagttagt ctccatcaaa ttgaacaggt gcttgcccta acagcacaag gcaataccat
    13501 tccctttatt gcacgttacc gtaaagaagt aacaggaaat ctagatgaag tggtgattaa
    13561 gtccattatt gatatggata agtctctcac taccctgaat gagcgcaaag caaccattct
    13621 cgctaaaatt gaggaacagg gaaaactgac agatcagtta cgaacgagta ttgaagcaac
    13681 cgagaaactc gctgatttgg aagagttgta cctgccttat aaggaaaaac gccgtacaaa
    13741 agcgacgatt gcgcgtgaag caggcttgtt cccattagca cgtttgattt tacaaaatgc
    13801 gcaaaacctt gaaacagcag cagaaccctt tgtcacagaa ggatttgcca gcccacaaga
    13861 agctctagca ggagctgtgg acatccttgt ggaggccatg tcagaagatg ctaaattacg
    13921 ctcttggacc tacaatgaga tttggcagta cagccgctta gtatcaacgc ttaaagatga
    13981 gcagttggat gagaaaaagg ttttccaaat ctattacgat ttttctgacc aagtgtctaa
    14041 catgcaagga tatcgtactt tagcccttaa ccgtggcgaa aagttaggca tcttaaaagt
    14101 gtcttttgag cataacttgg agaaaatgca acgctttttc agtgtgcggt tcaaagaaac
    14161 caacccttat attgaagagg tcatcaatca gaccatcaaa aagaaaattg ttccagctat
    14221 ggaaagacgg gttcgttcag aactcagtga tgccgcagaa gatggggcta tccacctctt
    14281 ttctgaaaat ctccgtcatc ttttgttagt gtctccttta aaagggaaaa tggttcttgg
    14341 atttgaccct gcctttcgaa caggtgcaaa attggctatc gttgatcaga ctggaaaatt
    14401 gttgactact caggttattt atcccgtagc accagctagc caaacgaaga ttcaagcagc
    14461 taaagaaaca ctgactcagc tcattgagac ttaccagatt gatattattg ccattggaaa
    14521 cggaacagcc agtcgggaaa gtgaagcctt tgtagcagac gttttgaaag atttcccaaa
    14581 tacgtcctat gtcatcgtta acgaaagcgg agcttctgtt tattcagcgt cagagttagc
    14641 ccgtcatgag tttccagacc tcacagtgga gaagcgctct gctatttcta ttgctcgtcg
    14701 cttgcaagac ccactcgcag aattggttaa aattgatcct aaatctattg gcgtcggtca
    14761 gtaccagcac gatgtgagtc agaaaaagtt gagtgagaat cttggttttg ttgttgatac
    14821 tgtggttaac caagtcggtg ttaatgtgaa cacggctagt ccatctttat tagcacatgt
    14881 gtcaggtttg aacaaaacga tttcagaaaa tattgtcaaa taccgcgaag aaaatggagc
    14941 actgacatca cgcgctgaca tcaaaaaagt gccgcgttta ggagccaagg cgtttgagca
    15001 agcagcaggt tttctcagaa ttccaggagc caaaaatatt ttagacaaca caggagttca
    15061 ccccgagtcc tacccagcag tcaaagaact ctttaaggta cttggtattc aggacttgga
    15121 cgacgctgcc aaggcaactt tagcagcagt tcaagttccc caaatggcag aaacattggc
    15181 tattgggcag gaaaccctta aagatatcat tgctgatctc cttaaaccgg gtcgtgacct
    15241 tcgtgatgac tttgaagcac caatcttacg tcaagatatc cttgatttga aagatttgga
    15301 aattggccag aagcttgaag gaactgtgag aaacgtcgtt gactttggtg cttttgtaga
    15361 cattggtgtt catgaagatg ggcttattca catttctgaa atgagcaaaa cctttgtcaa
    15421 ccaccctagt caagttgttt cagtgggtga cttggtaact gtttgggtct ctaagattga
    15481 cttggaccgc cacaaggtca atctcagcct attgccaccg cgtgacactc actaattatg
    15541 tccaagaagt ttccctggct gattttggca aaccatttca ccacaaggct tattggaaca
    15601 agcgcctaaa aacaactggc ggtcgctttt ttccaaaaga tggtcatttg gattttaacc
    15661 ctaggatgct tgaggagcac ggtgagctta tttttcggaa aattgttcgc catgagctct
    15721 gccattacca tctttatttt gaaggaagag ggtaccatca taaagatagg gatttcaaag
    15781 atctgctagc tcaagtaaac gggcttcgtt atgtcccaac tagctctaaa tcaaagacta
    15841 atcatcatta tagttgccaa acctgtgggc aggtttatca acgaaaaagg cgtatcaatc
    15901 tggctaaata tgtttgtgga aattgccacg ggaaacttat ggaaaaaaat cagtcgtaag
    15961 actggtttta ttttgcgaaa aacaatgtaa actagtatca tagaatgagg aggtaaagaa
    16021 acgtggaaac taaattctat aaacagcgaa aaaatcgctt ggttgcaggt gtcattgctg
    16081 gtttagcaga taagtatggt tgggatcttg ctctagcgcg tgtcttagcg gctcttctta
    16141 tttacggaac tggttttgga gttttgcttt atattttgtt ggccatcttc ttaccttaca
    16201 aggaagactt gcttgaagaa cgttatggcc gaggtcctcg tcgtcgtaaa gacgctgatg
    16261 tcttaaatga agaagaagat ggctggttct ggtaaacaat cagttaaaat gataattcat
    16321 cacgtaagag caaccatgtg attaactgat gataataaaa tgttttgata tgtaagtaag
    16381 cgaggggtct tatcagctat gatgaggctt tttgcttttt gacttagtaa gatgatacct
    16441 ttttaaatac cataataagc actaattgct caatgatact agtaaagtat ttgtttgcca
    16501 ttgtcttatt tttgactcat atctctaaat gataaaacct agtttttaat agagctaaga
    16561 ccatttttgg tgtcgttgct ctcatttagt agtgaaaaaa tgagtatttg caagggtcta
    16621 acggtcgatt tgtgttataa tattgaaaaa ggagaaatta tgaccgttac tgtaaagatg
    16681 ctagtgcaaa aagttaaact tgatgtggtt tatgctacag ataacttgtt gtcaaaagag
    16741 ataacaacat cagatatttc acgtccaggt cttgaaatga ctggttattt tgattattat
    16801 gctccagaaa ggttgcagct atttggaatg aaagagtggt cttatcttac acagatgact
    16861 tctcacaacc gttattctgt tttaaaagag atgttcaaaa aggacactcc tgcagtggtt
    16921 gtctctagaa atttagccat tccaaaagaa atggttcaag ctgcaaaaga agaaggtatt
    16981 tcacttttaa gtagccgtgt ttcaactagc cgcttagctg gagaaatgtc ttattttctt
    17041 gacgcttctt tagctgaacg tactagtgtt cacggcgttt taatggatat ttatggtatg
    17101 ggggttctta tccaagggga ttctggaatt ggtaaaagtg agactggttt agaattagtt
    17161 aagcgagggc atcgtttggt tgcagatgac cgtgtggatg tctatgccaa agatgaagaa
    17221 accctttggg gagagccagc agagatcttg cgccacttgc ttgaaattcg tggggtaggt
    17281 attattgatg tgatgtcgct ttatggagct agtgctgtga aggactcatc acaagttcaa
    17341 ttggccattt accttgaaaa ctttgaggct ggtaaagttt ttgatcgtct cggaaacggt
    17401 aatgaggaga taactttctc aggagtgaga atccctcgta ttcgtattcc ggtaaaaaca
    17461 ggtcgaaatg tttcagtggt tattgaagcc gctgcgatga atcatcgggc taaagaaatg
    17521 ggctttgatg ctacaaaaac ttttgaagat cgtttaactc aactaatcac caaaaatgag
    17581 gtgagtcaat gatcaatccc attgccttaa aatgtggtcc actagccatc cactggtatg
    17641 ctctatgtat cttgtcagga cttgttttgg cggtttactt agcatcaaaa gaagcaccca
    17701 aaaaaggaat atcatctgac gctattttcg attttattct gattgctttt ccacttgcta
    17761 ttgttggtgc aagaatttac tatgttattt ttgaatggtc ttattatgtc aagcatttag
    17821 atgaaatcat agccatttgg aatggcggta ttgctattta tggcggtctc attacaggag
    17881 ctcttgtact tttggcttac tgttataaca aggtgctcaa tcccattcat tttttagata
    17941 ttgccgcacc aagtgtcatg gtcgctcaag ctatcggtcg ctggggaaat tttatcaacc
    18001 aagaagccta tggtaaagct gtgagccagt taaattactt accaagcttt attcaaaagc
    18061 aaatgtttat agagggaagt taccgcattc cgacctttct ctatgaatca ttttggaatc
    18121 ttttgggatt tgtcattatt atgatgtggc gtcgtaagcc aaaaagccta ttagatggag
    18181 aaatctttgc attttactta atttggtatg gtagtggaag gctagtcatt gaaggtatgc
    18241 gaacagatag tcttatgttt ttaggtattc gcatctccca atatgtgtct gccttattaa
    18301 ttattattgg cttaatcttt gttataaaaa gacgtcgtca aaaaggaatt tcttattatc
    18361 aagaataagg atagaaaaag gagaaactta tggacttagt tggaatctca ctgatgatta
    18421 ttgcactcgc atttgttgct ttggtgattt tcttgattat tgtattaaag aaagtctcag
    18481 aaacaattga tgaagccaaa aaaacgattt ctgtattgac aagtgatgtt aatgtgacac
    18541 ttcatcaaac taatgatatt ttagcaaaag ctaatatcct tgttgaagat gttaatggta
    18601 aagtagcaac catcgatcca ttgtttgttg ctattgctga tttgtcagaa agtctttcag
    18661 atttaaatag tcaagcaagg cattttgggc aaaaagcaac taatgctaca ggtaatgttt
    18721 caaaagctgg aaaattagca ttagttggta aagtagcctc aaaagtattt ggaaaaaaag
    18781 gagaaaagca tgaataaaag tttcaaaaat ttagtgattg gagctgcttc aggagtagcg
    18841 gcagcttact tcttatcaac agaaaaaggc aaagctttga aaaatcgtgc tgaaaaagct
    18901 tatcaagcct acaaagaaag tccagatgat taccaccaat ttgctaaaga aaaaggtagt
    18961 gaatacagcc atttagcacg tgacactttc tatgatgtga aagataagtt ggcttctggt
    19021 gacttaacta aagaggacat gttagacttg ctcaaagata aaacaacagc tttcgtgcaa
    19081 aaaacaaaag aaacctttgc cgaagttgaa gcgaaagaaa agcaagatga tgttatcatt
    19141 gatttaaatg aagaagacat catcattgac tatactgaac aagatgagcc tgttagtgat
    19201 acattagaca aacactaact aaaatgactt aaaacataga agaagaaaag attgaaggat
    19261 ctgatcacta gtcccgatgg ttagttttag gctaactgaa gaaggggggg attgtggctt
    19321 caatcttttt ttgtttttga cacaaaaaaa aagagtcacg taaaacggac tctggaagtt
    19381 acatcagtaa tgatttgata accttggcta ataaggaagt aatgcctaag ctgatgatgc
    19441 ttgcaaataa gaaagcaaac attggcgcta aattcattac gagcaggaca aatgcaaata
    19501 aaacggtaat aaggctgaaa ctagcgatac gagcaaagaa gactaattct tttagctttg
    19561 cactttggcc attgaactct tgaaaatctc gaaatttact ttgagattct tggtaagaat
    19621 catcctgttc aaccgaatta tgcttcttta acggtgcagg catagtcccc tcctttcctt
    19681 aacatactaa gtaattctat cataaaagtc tcttcttgtc atcttttttt aaaagatttg
    19741 aaaagattta ctaatgacaa gtgacttatc atgctataac agtaagggga ctagcttaac
    19801 gtttgggctt ttgcaagaaa tatgcttaag gtcttaaaat ttttggtata ataaagctta
    19861 tatggaaaaa ataattatta cagccacagc tgaaagcatt gagcaagtca aagctttatt
    19921 agttgctggt gttgatcgta tttatgttgg tgaagccaat tacgggttac gccttcccca
    19981 taatttttct tatgatgaat tgagacaaat tgccaaacta gtgcatgatg caggcaaaga
    20041 gttgacagta gcttgcaatg ctttgatgca tcaagatatg atggatcaga tcaaaccctt
    20101 tttagactta atgatagaga ttgctgttga ttatcttgtg gttggtgatg caggtgtgtt
    20161 ttatgtcaat aaaagggatg gctataactt taaactgatt tatgatacct ctgtttttgt
    20221 gacttctagc cgtcaggtaa atttctgggg gcaacatggt gctgttgaaa gtgtcttagc
    20281 aagggaaatc ccatcagcag agttattcac cttagctgaa aatttggaat ttccagcaga
    20341 ggtgctagtt tacggcgcct cggtgattca tcactcgaaa cgtcccttgc tagaaaatta
    20401 ttaccatttt acaaagattg atgatgaggt tagtcgtgaa cgaggacttt tcttggcaga
    20461 accaggagat gctagcagcc attactccat ttatgaagac aatcatggca ctcatatttt
    20521 cattaataac gatatcgaca tgatgtctaa attgggtgag ctgtatgcgc atggcttaac
    20581 tcattggaag ctagatggca tttactgtcc aggtgatgat tttgtcgcta ttactaaatt
    20641 gtttattcag gctaaaacct tattagaagc tgggcaattt acccaagaag aagctgaaaa
    20701 gcttgatcaa gcagtgcatg cccatcatcc agctggccgt ggattagata ctggctttta
    20761 tgagttcgat ccaaaaaccg ttaaataagt aatccttgtc ttgagtgagt ttactatttc
    20821 agggcaagac agggttatga caccattaca caggtaatct acctatcttg aaaatagaaa
    20881 gaatatcaca tgtcacatat gaaaaaacgt cccgaggtct tatcacctgc tggaacactt
    20941 gaaaaattaa aagttgcgat tgactatggc gcagatgctg tttttgttgg aggacaggcc
    21001 tatggcctaa gaagccgcgc tggtaacttc tctatggaag aattgcaaga aggcattgat
    21061 tatgcacatg cgcgtggagc taaggtttat gttgctgcca acatggttac ccacgaaggg
    21121 aacgaaattg gtgcgggcga gtggtttcgt caactgcgtg atatggggct tgatgcggtc
    21181 attgtttcag atccagcctt gattgttatt tgttcaacag aagccccagg tttggaaatt
    21241 catttgtcaa cgcaagcttc atctaccaat tacgagacct ttgaattttg gaaagccatg
    21301 ggtttgacgc gtgttgtttt agctcgcgag gttaatatgg ccgagttagc agaaatccgt
    21361 aagcggacag atgtggaaat tgaagccttt gtccatggag ccatgtgtat ttcttattca
    21421 ggccgctgtg ttttgtcaaa ccacatgagt caccgtgatg ccaacagggg cggctgctca
    21481 cagtcttgcc gctggaagta tgatttgtat gacatgccat ttggaggaga gcgccgctcc
    21541 ttaaaagggg aaattccaga agactattct atgtcctctg ttgacatgtg tatgattgac
    21601 catattcctg acctgattga aaatggagtt gatagcttaa aaattgaagg ccgaatgaaa
    21661 tctatccact acgtctcaac cgtaaccaac tgttacaagg cggctgtaga tgcttacatg
    21721 gaaagcctag aagcttttta tgctatcaaa gaggaattga ttgacgagtt gtggaaggtt
    21781 gcccagcgcg agttagctac aggtttttac tatggtatcc caactgaaaa tgaacaatta
    21841 tttggtgctc gccgcaaaat tccacaatat aaatttgtcg gagaagtagt tgcctttgac
    21901 tcagctagca tgacagcgac cattcgtcag cgtaatgtca tcatggaagg cgatcggatt
    21961 gaatgttatg gaccaggttt ccgtcatttt gaaacggttg ttaaggactt acatgatgcg
    22021 gatggccaaa agattgatcg tgccccaaat ccaatggaac tcttaaccat ttctttgcca
    22081 agagaggtta aaccaggaga tatgattagg gcttgcaagg aaggtctggt taacctctat
    22141 caaaaagacg gtacaagtaa aactgtcaga gcttaattga aataaatatg aaaggccctt
    22201 tttccctagt ggcgtaaaag ctgcgtttgg gataaaagag ccagtttttt gaaaattaga
    22261 taccacgata gcttattttc tcaaaacttg ataaaataag gtcatcataa ctaaaaagtt
    22321 gaaaaaaaga ttgcttttgt caatttattt tcgaatagta taagtaagga ggaaaaaata
    22381 atggcagaat ttacgtttaa aattgaagaa cacttactca ccttgtcaga aaatgataaa
    22441 ggttggacga aagaattgaa ccgcgtcagc tttaatggcg cagaagcgaa atgggatatc
    22501 cgcacgtgga gtccagacca tacgaaaatg gggaaaggca ttactcttac taatgaagaa
    22561 tttaaaacca tcttagacgc ttttcgtaag taatgctacc ttaatcgaaa cataatccct
    22621 cgttcgccct tgtcctctta acctggtgat gacatcgcta ggttaagagg acaggggcga
    22681 atagaaggat tatttttttg aattgaggcg gtcagcaagg ccgacaagta ccaaaattaa
    22741 gcctagccca agaaaaatcc atttggcagc taaaaggcca taaagcaaga agatagcagc
    22801 actaatgtag gagatatatt ctttggtcat cttgttaagt cactttctat aagctactgt
    22861 taataaacca gtcttcatgg taatgaagac tggttagaga taataaaacg ttatgttata
    22921 ttgccactta tcggttttaa gatatgaata caaatcttaa aaaagttaag gtttcatcgt
    22981 tgggaataaa agcacatctc tgattgttgt tgtgtttgtt aataacatgc aaagacgatc
    23041 aatcccgatt ccgagtccac cggttggcgg cataccatat tcaagagctt caacgaagtc
    23101 gtagtcaatg ccagttgctt cgtcatcacc aagttcttta gcttgtgctt gtgcttcaaa
    23161 acgagataat tggtcaatgg gatcattcaa ctctgtgaaa gcattggcgt attctttggt
    23221 catgatgaaa agttcgaagc ggtcggtgaa gcgggtatct tctggattct tcttagccaa
    23281 aggtgatact tcaacaggat gaccaaagac aaaggttggt tggaccaagg tttcttcaac
    23341 gaattcttcg aagaaagcat tgatgatatg tccgacactt gtgaagtgtt tttcgagtgg
    23401 gacctgtttt tctttggcaa gtgcaatagc ttcttcgaca gtcatttcag gccagaaatc
    23461 aacacctgtc acttccttga tagcatctac catgtggaca cgtttgaaag gttcattgat
    23521 acggatttcg gttccttgat aatcaatagg gccatcacct ttaacagctt tagcagcatg
    23581 ttggataatg ccttctgtca ggttcatgat atcaagatag tctgcatagg cttggtaaac
    23641 ctcaatagaa gtgaactcag gattatgagt agcatccatt ccctcgttac ggaagatacg
    23701 accaatttca tagacacgtt ccataccacc aacaatcaaa cgtttcaaat gaagttctgt
    23761 tgcgatacga agcaccatat caatgttttg agcattatgg tgagtaacga aaggacgagc
    23821 agcagcacca ccagcctcgt tatgaagcac aggcgtttct acttctagga aatcaagacc
    23881 gtctaaataa cgacggattt ctgaaatcat tttggaacgg gtcacgaagc ggtcaaagct
    23941 ttcacgattt gaaattaaat caaggtgacg cttacggtaa atggtttcaa tatcagttaa
    24001 tccgtggaat ttttcaggaa gaggacgaag tgatttagaa aggtgagtca acttggttgc
    24061 cttgattgac aactcgccca tgtctgtacg catgacttcg ccttcaacgc cgataaagtc
    24121 gcctaaatcg gcttttttga agatttcata gttgtcttcg ccaacagagt ccttgcgaac
    24181 ataaagttgg atttggcctt cacggtcttg aagatgagca aaaccaacct tacctttgcc
    24241 acgttttgtc atcaagcggc cagcaacaat agctgtttcg tttaactcat gtaattcttc
    24301 ttttgtttta tcagcatact tttcttttaa ttcagcagaa ttggctgtgc ggtcaaagcg
    24361 tttaccgaaa ggatcaattc cttgttcagc cagagccatc atcttttcac gacggacaat
    24421 ctgttggtca tttaattctt cgatgtgttg attagacata ttttcctcca atacgatttc
    24481 ctttccattg tatcataaaa gaggctagaa tacacctata tttcgttgga aaatgcgact
    24541 gcagcggggc acttttttga aaataaaatt gaaaagccta atggaaaata gtataatgat
    24601 tgggatatta aactagaaaa gaaaagagac tcatgattac tgctattgtt tttgatgtgg
    24661 atgacacaat ttacgaccag caagcgcctt atcgaatcgc catggaaaag tgcttcccag
    24721 attttgatat gtcagtaatg aatcaagctt atattcgctt tcgtcattat tcagatgttg
    24781 gattcccaag agtaatggca ggggagtgga ccacagaata tttccgattc tggcgttgca
    24841 aggaaacact gcttgagttt ggctatcgag aaatcgacga agctgcggga gtacattttc
    24901 aagaagtcta tgagcacgaa cttgagaaca ttaccatgtt agatgagatg cgcatgaccc
    24961 ttgacttttt aaaatcaaag aatgttccta tggggattat taccaatggg ccaacagaac
    25021 atcagctgaa aaaagttcgt aaattagggc tttatgatta tattgaccct aagcgtgtca
    25081 ttgtgagcca agcaacaggc tttcaaaaac cagaaaaaga aatttttaac ctggcagcag
    25141 aacaatttga catgaaccca caaaccacac tatatgttgg ggactcttat gacaatgata
    25201 tcatgggtgc ctttaatggt ggttggcatt ccatgtggtt taatcataga ggtcgtcagc
    25261 taaaaccagg aactaagcct gtttatgatg tggctattga taactttgaa cagctctttg
    25321 gtgccgttaa agtactcttt gatttacctg ataataaatt tatttttgat gtcaatgaca
    25381 agaaaaatcc aattttacag atgggaatca ataatggctt gatgatggca gcagagcgtt
    25441 tacttgaaag caacatgagc attgacaagg tggttatctt gcttcggtta accaagcaac
    25501 aagaaaaagt tttgcgctta aaatatgcca gatagatgaa accataatag cccactagat
    25561 aataataaaa aaagctagca aagtgagtgt cttgtcagta agagatcaat gtgttagctt
    25621 tttttattat tgtctagtgg ttttacacct ctagaaaaga tttatcattc caaattaaac
    25681 agtcataagt taaataatct ttagtttcaa gaatagtaag actggcatta tctaagccac
    25741 ctttagcgag taaaagagca ggttcaaaac ctaataatga gcgaatagtt gctgttaagt
    25801 tagcgccgtg tcctacaata agaacgtttt gataatgttt atctttaaac gattggataa
    25861 gatggcagac acgttgagtc gtttggtaaa ttgattcagc ctcgaactga tctggtttga
    25921 actgggctag attctcccga aaagccagca tttgttgggg atatatagct gccattgttg
    25981 ctattttagc cccttccaat ttacctaatc tccactcccg aagctggtcg gtgtggtaaa
    26041 gttttggctg ttggtcaaaa gcatctaaga taatagctgc tgttgccata gctctttgaa
    26101 ggtcgctagt ataaacggca tcaaaagcca ccttagctaa ctctttgcca agtaagtgaa
    26161 tttcgtcttt tgcctcttca agtaatggcg aatcgccccc agcgccttga aagcgacctt
    26221 ctaaattcca aagggttttc ccatgtctta caaaatataa tttcatttaa gcctcctttt
    26281 agagataact gatgcgagcg ctaaaaataa aaaagtaacc agaaaaagtt ggcagtagtg
    26341 ttcattttct cttctttaaa tcagcaaagc ttgcgccaac gaaatcagct agagcctggc
    26401 tagaaatctt tatagaacgc ccaacttcac cagctgaaac gattatttga cctttttcca
    26461 gtgcagtttg gtcaataaaa ataggatatg aatgtttttg acgaatccca acaggattat
    26521 tggcaccgtg aatatagcct gttgtctttt gcaagtcttt ttgaggaacc atggacactt
    26581 ttttgttacc tgatactttt gccaattgtt tttctgataa gtgttctgtt aatggaataa
    26641 tgccaattag aggacctgtt tgatcgccag tcagagcaag tgtcttgtaa atatctgatg
    26701 gttgaagatc atctggaaag tcgccttcta aagcattaag cttgagtcct tgatgagcaa
    26761 tattagcctt atcgaggatt tgttctacta aggttttttt gagttttgtt tttttagtca
    26821 tatcaagtcc ttacctttat ctaaacataa aaaaatggta taacaacatt attataccat
    26881 ttttttttaa tgtaagattc aaatgactaa aaattagtct ttgggatcaa ataattgagg
    26941 atgaattggt aaagcaatca ttaacgctaa acatgttatt aaaaaagtta ggacaccagc
    27001 tgtaccatta acgctaaaag aataccagac agcggacatg cctttagggg cgtaactgcc
    27061 ccagaaaatg attcctgcaa ggaagtgcca caagtaacgc actgtaacgg ctagtaaact
    27121 agccattatt gcaagaaaaa cggcaaaaaa ggtttgttgt cttcttaaag ttttaatcaa
    27181 actatcagag aaactaccgg ctaatcccat agaggtaaag gctaagatat attcaataaa
    27241 gacttgggac atgctgagat agtaaacttt tccaagtaca aagtgaagta gcccccaaat
    27301 gagacccgcc aacatgccgt actttaaccc acggcgcaaa gagaaaataa ccagtgcaat
    27361 agcaccataa gaaggactaa accagccagc aaaatctgga ataaatgaaa gggtcatcgc
    27421 caatgcagca aaaatagcag cttcgataag gtatttgaca ttggtgtttg gtaacataaa
    27481 aaactccttt tgtgcacaaa aagagtatcg ctttccaatc attgattatt ggtcacaatc
    27541 cctacgcttg tactaacaag atcaggtcct caggatttcg caattgcgat ctcagccaaa
    27601 gcactccttt gtgaaatatt atagtgcttt cattatatga tgagataatc tccttgtcaa
    27661 ggataagggg gtttaaatta ttgacctaga gtttttcttg gtaagatgta aactacaaaa
    27721 aagattagcc atgatgctaa cctcttaatt gttggagttg ccaaataact tctcaaacgt
    27781 ttttttagtg tcttttgtta cggcaatttg atttaaatct aaagcattgt taaaaccact
    27841 gagataacct tgtgaggtat attggtgtaa atcgtaatct aaggttgtat taggagcagc
    27901 ctcataatag ccagaatcac taccataagt cggaatccat acagcatcga aaccttttgt
    27961 tgaaatatct tgttctgcca taaaataagt gccaatatag agaccaacat tttcagcacc
    28021 aagtttttta agctcttctc ggaaggctgt tacgccttta ttcatatctt tcatagtggc
    28081 ttcttcgaca tcaatccagt agtaagttgg attataggga gcagcgtttt tgtagaaagt
    28141 tcgggcctct tctttcatct ctttagtact acgaccaagt gcgtaactgt aaacagctac
    28201 aggaacattt cgtttttgaa attctttgat atgcgtttta aaagatttgt caattccagt
    28261 tgtaaaagca gcgttgttat gagctgtaat ttgcgatcct ccatagacac gtacaattgc
    28321 gccagagatg tgacgcgaca atgtgtcata atcaatttct tcagggagtt gccagccgga
    28381 aacatcaaca ataggattta aaataaagtc ttcggtttca gaagtgctag tttttgcttt
    28441 actaggatta ctggttgcaa taggaatatg actcttagcg tcttcaactt ctttttgttt
    28501 cgcatgatta gcttgtcttt ttccgataat caataccatt gccagtaaaa taaagaagac
    28561 tagcacaaca ataggtttta ttcttcttct cattaactgt tattgtaccc taattactaa
    28621 aaaaaatcaa aatatcctaa ctgttttctt atattgtctt gcattttaag gtattatctt
    28681 ttagaagtta caaatgagat cctccctaac tatgtcaagt ttatgtcact atctcttata
    28741 gttggtagct atattcttta caatattagt ttagtctttg actatatcat gacagtcagc
    28801 aagtattgtt ttgttattta attctcatgt tattatcatt tgataaataa gtgagctcca
    28861 aactggtaaa cgctctgtaa atctgtcata atagagaaaa aaacgaggaa gaagtttatg
    28921 tcagctaagc ttatgagtcg cattgctatc atgtcagccc tatgtgttgt gttgagaatg
    28981 gtttttagca gcctgcctaa cgtgcagcct gtgacggcat ttttactcag ttatcttctt
    29041 tactttgggt tagccgaggc tgtattagtt atgatgttgt gcttattttt atcggccttt
    29101 ttgctgggat ttggcccttg ggtcttttgg caagttactt gttttgcgct tgttctttta
    29161 ttatggcgtt ttgtcttgta ccctctgtct cagcaattcc ccaaatatca gcttggctgt
    29221 caggctttct tggccgcctt atgtggcctc ctttatgggg tgttgataga cacttgtttt
    29281 gcgtatttgt atagtatgcc ttggtggagc tatgttctag ctgggatgcc ctttaatata
    29341 gcgcatgctt tatcaactct cgtctttttt ccagttgtga tgatgttatt taggaggtta
    29401 atcggtgaac aaaagattta aaacaggatt tctagcgctt gttgctatgc tacttgttgc
    29461 ttgctcgcaa ggaacaaaac aaacacagac tccaagcgtt ccaaaagcag accatcacgt
    29521 tcgcttagtt gtcaaagaag ataccaatac cattgatgaa aaagtttctt ttggaaaagg
    29581 agatacggtg cttgagattc tcaaagataa ttatgaggtc aaagaaaaag atggctttat
    29641 cactgctatt gatggtattg agcaagacac gaaagctaac aaatactggc tttttaaggt
    29701 gaatggaaag atggcagata agggtgccga tcaaatcacc gttaaagatg gtgatagcat
    29761 tgaattttat caagaagttt ttaaatagta actataatac aaaatagact tggcacgcca
    29821 agtctatttt gtattaacca agaagtgctt taaggtcttc ttcaattagt ttaggatctg
    29881 tctttgagga atagcgttta atgacttgac cattttggtc aatgagaaat ttagtgaaat
    29941 tccattcgat gcgtttccca aggggaccac ttttttcttc ttttaaccag gcaaacaaag
    30001 gatcagcgtc tttaccattc actttgattt taacaaagcg agggaaagta gtgtgatagg
    30061 tcagactgca aaagtgatta atctcctcag catctcctgg agcttgattt aaaaattggt
    30121 tgcaaggaaa atctaagacc tcaaatccct tgtcatggta tgtgtcatat agtgcttgca
    30181 aggcctggta ttgtggggtt aatccacact tggtagctgt attaacaatc aaaacaacct
    30241 tttctttata agcagctaag gaaaggtcat tcccgttttg agccttaacc gtaaaatcat
    30301 agagattagg catgtgacat ctcctcggtg taattgataa tttggtcaac ggtatcactc
    30361 aagaattgaa tggtatctcg aagaggcttt tcagtggcaa tgtctgcccc aatgagcatt
    30421 gcagtatcaa gaggcgtacg gctgccacct gattttagga aatcaagcca ttcttttgcc
    30481 ccatctgggt tgtttttaag gttaaggtaa ccagctgttg acataacaag cccagcagaa
    30541 taggtgtaac tatataagcc catgtagtaa tgcgcttggc gcatccaggt aagagctgcg
    30601 tcatcgtcaa tgtcaacggc atctccccag aagtctgtta agacctcttt catcattgca
    30661 tttaattggt cagctccaaa ggtaccgcct tcttcaatca gggtgtaaac cttacgttgg
    30721 aaagccgctt ccaataggtg agtgatgaag ttatgaaagt aagtatctgt taaacggtga
    30781 gcaagagcaa aacgtttttg acgagggtca tcaaactgat gttccaagta atcactaagc
    30841 atcaattcat taaaggtcga tggcgcttcg acgtaataag ttgacatatg agtattgaag
    30901 taactttggt gattatctga aaaaatgaat tgaccagagt gaccgatttc atgaataagg
    30961 gtataaacat cagacattct tccagtccaa ctcattaaga catacggatg aaccttgtag
    31021 ggatcagcgg cataaccacc agaatcctta ttggcgttag cagcaaagtc aacccagcgt
    31081 tcagtttggt aacgttcgat ttctttcgtg tattcttgcc ctaatggggc tagagatttc
    31141 atcacgaggt cataagcgcc atcaatgctg acttctggat tgagatcatt gtcaatatct
    31201 agtttccagt cagcaaaagt cattttctca agaccattga cttgggcgac atgttttaag
    31261 aatttctgag caaccggtcc aaattcagtc atgatgagat caatttggcg gtcgaacaag
    31321 ctacgatcca cttcctgttc agctaggagg taatcaaaga cagaagcgta gcctttcata
    31381 tccgctaaca gtttttcaga tttaaccttg gctaagtaag ccgctgcagc tgtattttgg
    31441 tgtttacgga gaccttttga aaaagagcgg aaggcttttt cacgaatctc agcattttcg
    31501 tgattttgat agaaattttc gtaagaaaca aagctatttt tataggtttt accatccacc
    31561 tcaaaatcct ccatgtcaaa gtcaccagcc cgcattttgg tgtaaatatc atagggcgca
    31621 ttgataacct cgcgtaagtt agccaaagcc ttttccacat caggacttaa gaggtgttct
    31681 ttttggattt ttgccatgcg aatagctgcg ctgaaataag ggttcttttc taatgtatct
    31741 aacacgtcaa ggtcggcatt ggctaaggcg gtgtcaaaga agctaagggc aacgctagct
    31801 ttagtcatga aatcatcgcc agcctgagca atttgagcaa aactttcatc tgaaaagtca
    31861 gtggtttgag gcataaaggc ataagtgcca atatgactca tttgaatata aatatgctca
    31921 atttctatta aggcctgagt gaaatcgtcc accgatgtta agcggccttc ataattgcgc
    31981 ttaaacaggt caatatcttg taaggctttt tcaatagcga gtaaaaaatc ttggcggtct
    32041 ttatagagcg ctgttagatc ccaaagttca ttttcaggga attctgaacg ttttttcaat
    32101 tccatagttg tctccttaac aatatagtca agactagtat aacagaattt tagtggaata
    32161 tggagactaa acctatccaa acattcttta aaataaagcg cttacttttt ttaaaaaaca
    32221 aacgttatgg acatgatcac ttttattttt ggtaaaaagt ggtatgatag aagaaactag
    32281 caaagaagga gatggtcatt tgccacttaa aaagttagag agtagtaaca atcaaactat
    32341 cattgctgaa gaagttgctc ttttgaaaga aatgttggaa aatatcacac gacggatgat
    32401 tggagatgat gcgtttacag ttatcgagtc tattatggtg ttatctgaaa aacaagatta
    32461 catagaatta gaaaaagttg ttgccaatat ttcaaatcaa gaaatggaag tgatttccag
    32521 gtatttttct attttaccct tgctaatcaa tatttcagaa gatgtcgatt tagcctatga
    32581 aattaatcat caaaataata cagatactga ttatttaggg aaattagccc taaccatcaa
    32641 ggatcttgct ggaaaagata atggtaaaga cattttggag caggttaatg tggttcctgt
    32701 tttaacagca catccgacgc aagtacaacg taaaacgatt ctggaattga caactcacat
    32761 tcataaactt ctgcgcaaat accgtgatgc taagactggt gtgattaatc ttgagaaatg
    32821 gcgtcaggag ctatatcgtt atattgaaat gatcatgcag acagatatta ttcgcgagaa
    32881 aaagcttcag gtgaaaaacg agataaaaaa tgtcatgcag tattacgatg gttctctcat
    32941 tcaagctgtg accaagttga caacagagta caaaaactta gctcaaaaac acggtctaga
    33001 gttagacaat cccaaaccca ttaccatggg gatgtggatt ggtggggacc gtgatgggaa
    33061 cccctttgtc acagctgaaa ccttgtgctt gtcagctacg gttcaaagtg aggttatcct
    33121 caattactac attgacaaat tagcagccct ttaccgaaca ttttcactgt cgtcaacctt
    33181 ggtacaaccc aactcggaag tggaacgttt agccagtttg tctcaggacc aatcgattta
    33241 ccgtggaaat gaaccttatc gcagagcttt tcattatatt caatcgcgtc ttaaacaaac
    33301 acaaattcaa ctaactaatc agccagcagc tcgtatgagt agtagtgtgg gactaaacac
    33361 atctgcttgg tcctcaccag ctagtttaga aaatcccatc ttagcctatg actctcctgt
    33421 tgattttaaa gctgatttaa aggctattga gcagtcgcta cttgataatg gcaacttcgc
    33481 tttgattgag ggggatttgc gagaagtcat gcaagctgtt gatatttttg gcttcttctt
    33541 agcaagcatt gacatgaggc aagactccag tgtccaagaa gcttgtgtgg cagagttatt
    33601 aaaaggagcc aatattgttg acgattatag ctctctttca gaaactgaaa aatgcgatgt
    33661 tctcttacaa caattaatgg aggagccaag gactttatcc tcagcggcag ttgctaaatc
    33721 agacctatta gaaaaagaac tggctatcta tactacggca cgagaattga aagataagct
    33781 tggagaagag gttataaagc aacatattat ttcacataca gaaagtgtct ctgatatgtt
    33841 tgagttggcc attatgctta aagaagtggg attggttgac cagcagcggg ctcgtgtgca
    33901 aattgttccc ctctttgaaa ccattgagga tttagataat gcccgtgaca tcatggcagc
    33961 ctatttaagc catgacattg tcaaatcttg gattgcaacg aatcgtaatt accaagaaat
    34021 catgttaggc tattctgaca gtaacaaaga tggtggctac ttggcatcgg gttggactct
    34081 ttataaagct cagaatgaat taacggctat tggtgaggaa catggagtga aaatcacctt
    34141 cttccatggt cgtggaggaa cagttggtcg aggaggtggc ccttcttatg atgccattac
    34201 ttcacaacct tttggttcca tcaaagatcg gattcgtctg acagagcaag gggaaattat
    34261 tgaaaacaaa tacggcaata aagatgtggc ttattaccat ttagaaatgt tgatttcagc
    34321 ttctatcaat cgtatggtga ctcaaatgat aacagatcct aatgagattg atagttttcg
    34381 agaaatcatg gatagcattg ttgctgatag caataccatt tatcgaaaat tggtttttga
    34441 caatccccat ttctatgatt atttctttga ggcaagcccg attaaggaag tttccagtct
    34501 caacattggg tcaagaccag cagcccgtaa aacgattacg gaaattacag gcttgcgtgc
    34561 cattccttgg gtcttttcat ggtcacaaaa tcgcatcatg ttcccaggtt ggtatggggt
    34621 aggttcagcc tttaaacgtt atattgaccg agcacaaggt aaccttgaac gcctccaaca
    34681 catgtatcag acgtggcctt ttttccattc cttgttatca aatgttgata tggtattatc
    34741 taaatcaaac atgaatattg cctttcagta tgcacaacta gctgaaagtc aggatgttcg
    34801 ggatgttttt tatgaaattt tggatgagtg gcaattgaca aaaaatgtta ttcttgctat
    34861 ccaagaccat gatgatctat tggaggataa tccctccctt aagcatagct tgaagtcacg
    34921 cttgccgtat tttaatgtgt tgaactatat tcaaattgaa ttgattaaac gttggcgtaa
    34981 taatcaactt gacgaaaatg atgaaaaatt gatccataca actatcaatg gcatagcgac
    35041 tggtttacgt aattcaggct aatgctcttg agtattaatt ggtatttata gaagttttca
    35101 agtgactaat cagaatttta aaggttagcc cttggagctt ctttttttga ggattcttga
    35161 ctttttcttt tgtttgatat agaaagatgt tataatgcta aatgattatc tcaagaagta
    35221 gagggaaaac tatgaagatt gataaaaggc acctcttaaa ttattctata ttattgcctt
    35281 atttaatttt atcggtgata ggcttaataa tggtttactc aaccacaagt gtcagcttga
    35341 ttcaagcaca tgctaatcca tttaaatcgg tgattaacca gggagttttt tggataataa
    35401 gtctagtggc tattacattt atctataaat taaaattaaa ttttttaacg aatacaaggg
    35461 tattaactgt ggttatgtta ggagaggcct ttcttttaat tattgcccgc ttctttacaa
    35521 ctgctatcaa aggagcgcat ggttggattg tgatcggacc agtcagcttt cagcctgctg
    35581 agtatttaaa gatcattatg gtatggtatt tggcattgac ctttgctaag atccaaaaaa
    35641 acattagcct ttatgattat caagcactaa ctcgtcgaaa atggtggcca acacaatgga
    35701 acgatttacg ggactggcgt gtttattctt tgttgatggt acttttggtt gctgctcagc
    35761 ctgacttggg aaatgcttcc attattgtat tgacagccat tattatgttt tctatcagtg
    35821 gcattggtta ccgatggttt tcggctatcc tagtcatgat taccggtcta tccacggtct
    35881 ttcttgggac tattgccgtt attggggtag aaagagttgc taagattcct gtttttggct
    35941 atgtcgctaa acgttttagt gcctttttta atcctttcca tgacttgacc gattcaggtc
    36001 accaattagc caattcttac tatgctatga gtaatggtgg gtggtttggc caagggttag
    36061 gaaattccat tgaaaagcgt ggttatttgc ccgaagcaca gacagacttt gtcttttcag
    36121 ttgtcattga agagttaggt ctaataggag cagggtttat tttggcactt gttttcttct
    36181 taattttacg tattatgaat gttggtatta aagcaaaaaa tccttttaat gccatgatgg
    36241 ctttaggagt aggcggtatg atgctcatgc aagtctttgt taatattggt ggtatctcag
    36301 ggttaattcc atctactggt gttaccttcc cttttttgtc tcaaggtgga aatagcttac
    36361 ttgtcttatc tgttgcagtg ggttttgtac taaatattga tgctagcgaa aagcgagatg
    36421 atatatttaa agaagctgaa ttatcttatc gaaaggacac tcgaaaagaa aatagtaaag
    36481 ttgtaaatat caagcaattt caataatatt ctaaaatctc ctttaaggag attttagaat
    36541 atagacaatc ccagtttgat gctcaaa
//
LOCUS       DAUDWO010000018        36327 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.018, whole genome shotgun sequence.
ACCESSION   DAUDWO010000018 DAUDWO010000000
VERSION     DAUDWO010000018.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 36327)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 36327)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..36327
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.018"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..251
                     /locus_tag="VHC05_000864"
     CDS             <1..251
                     /locus_tag="VHC05_000864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEQ5402187.1"
                     /translation="INDLIDLPKLKKDIEELNHLKDDYNKAIKLNYLDKKNEDSLGML
                     MDNIDIRKSSYDVQSRIVKQLIDRVEVTMDNIDIIFKF"
     gene            complement(448..1359)
                     /gene="whiA"
                     /locus_tag="VHC05_000865"
     CDS             complement(448..1359)
                     /gene="whiA"
                     /locus_tag="VHC05_000865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein WhiA"
                     /protein_id="HEQ5402188.1"
                     /translation="MSFTTKVKEELIHLSTGDNNELAAIIKLSGSLGLAHQSLHLSIT
                     TENAKIARYIYSLIEDAYVIVPEIRYHQKTNLRKNRVYTVYVEQGVETILADLKLADS
                     FFGLETGIEPQVLSDDNAGRSYLKGAFLAAGSIRDPESGKYQLEIYSVYLDHAQDLAQ
                     LMQKFMLDAKTIEHKSGAVTYVQKAEDIMDFLIIIGAMSCKEDFEAIKLLREARNDIN
                     RANNAETANIAKTISASMKTINNIIKIMDTIGLESLPIELQQVAQLRVKHPDYSIQQV
                     ADALEFPITKSGVNHRLRKINKIADDL"
     gene            complement(1356..2333)
                     /locus_tag="VHC05_000866"
     CDS             complement(1356..2333)
                     /locus_tag="VHC05_000866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvcK family protein"
                     /protein_id="HEQ5402189.1"
                     /translation="MKNPKMTVIGGGTGISIILKSLRNEAVDITAVVTVADDGGSSGE
                     LRNAMQLAPPGDLRNVLLAMSDMPKFYERVFQYRFNESDGALAGHPLGNLIIAGISEM
                     QGSTYNAIQILTKFFHITGKIYPSSEQALTLHAVFKDGHEVAGESSIAKYQGMIDHVY
                     VTNTYNDQKPQASRKVVEAILESDMIVLGPGSLFTSILPNLVIPEIKEALRQTKAEVV
                     YICNIMTQYGETEQFSDADHVAVLNQHLGRDLIDTVLVNVAKVPQAYMNSNKFDEYLV
                     QVDHDFAGLCRAAKRVISSYFLRLENGGAFHDGNLVVEELMNLVRIVKQ"
     gene            complement(2330..3220)
                     /gene="rapZ"
                     /locus_tag="VHC05_000867"
     CDS             complement(2330..3220)
                     /gene="rapZ"
                     /locus_tag="VHC05_000867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002282100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNase adapter RapZ"
                     /protein_id="HEQ5402190.1"
                     /translation="MSDKHINLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALVPK
                     FLELIEQTNENRRVALVVDMRSRLFFKEINSTLDSIESNPSIDFRILFLDATDGELVS
                     RYKETRRSHPLAADGRVLDGIRLERELLSPLKSMSQHVVDTTKLTPRQLRKTISDQFS
                     EGSNQASFRIEVMSFGFKYGLPLDADLVFDVRFLPNPYYQVELREKTGLDEDVFNYVM
                     SHPESEVFYKHLLNLIVPILPAYQKEGKSVLTVAIGCTGGQHRSVAFAHCLAESLATD
                     WSVNESHRDQNRRKETVNRS"
     gene            complement(3634..4980)
                     /gene="asnS"
                     /locus_tag="VHC05_000868"
     CDS             complement(3634..4980)
                     /gene="asnS"
                     /locus_tag="VHC05_000868"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HEQ5402191.1"
                     /translation="MSKKLISIVDVKDYVGQEVTIGAWVANKSGKGKIAFVQLRDGSA
                     FFQGVAFKPNFIEKYGEESGHEKFDVIKRLNQETSVYVTGIVKEDERSKFGYELDITD
                     LEIIGESHEYPITPKEHGTDFLMDNRHLWLRSRKQMAVMQIRNAIIYATYEFFDQNGF
                     IKFDSPILSENAAEDSTELFETDYFGKPAFLSQSGQLYLEAGAMALGRVFDFGPVFRA
                     EKSKTRRHLTEFWMMDAEYSFLSHEESLDLQEAYVKALIQGVLDRAPQALDILERDVE
                     ALKRYITEPFKRVSYDDAITLLQEHEADEDTDYEHLEHGDDFGSPHETWISNYFGVPT
                     FVVNYPASFKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREDNYDTLVAKMDEL
                     GMDKSEYDFYLDLRKYGSVPHGGFGIGIERMVTFVAGTKHIREAIPFPRMLHRIRP"
     gene            complement(5001..6194)
                     /locus_tag="VHC05_000869"
     CDS             complement(5001..6194)
                     /locus_tag="VHC05_000869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEQ5402192.1"
                     /translation="MPKLSKRVLEMKESVTLAAGARAKALKAQGRDVLNLTLGEPDFF
                     TPKHIQDKAIESIQNGTASFYTNASGLPELKAAIATYLKNQYGYHLSPDQIVAGTGAK
                     FILYAFFMAVLNPGDQVLIPTPYWVSYSDQVKMAEGQPIFVQGLEENQFKVTVDQLER
                     ARTSKTKVVLINSPSNPTGMIYGAEELRAIGEWAVHNDILILADDIYGSLVYNGNQFV
                     PISTLSEAIRRQTITVNGVAKSYAMTGWRVGFAAGEPEIISAMSKIIGQTTSNLTTVS
                     QYAAIEAFCGSQSSLEEMRLAFEERLNIIYPLLCQVPGFEVVKPQGAFYFFPNVKKAM
                     EMTGFSDVTSFANAILEEVGLAVVSGAGFGAPENVRLSYATDIETLKEAVRRLHVFME
                     SNEIN"
     gene            complement(6530..9031)
                     /locus_tag="VHC05_000870"
     CDS             complement(6530..9031)
                     /locus_tag="VHC05_000870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional DnaQ family
                     exonuclease/ATP-dependent helicase"
                     /protein_id="HEQ5402193.1"
                     /translation="MFCFIDIACYNRLTMTQKKLRKYAVVDLEATGAGPNASIIQVGI
                     VIIQGNKIIDSYETDVNPHESLDEHIVHLTGITDKQLAKAPDFGQVAHHIYQLIEDCI
                     FVAHNVKFDANLLAEALFLEGYELTIPRVDTVELAQLFFPRFEKYNLGHLSRQLNIDL
                     AEAHTAIADARATAILFLRLLQKIESLPIECLESLLVYSDSLLFETAMVIQEGLAKAK
                     PYDPNKYIKIRQILLPKGSKALKSYQISKSFPINIALLGLEERPKQTQFAQLIDEDYH
                     QGVASFIEAQTGIGKTYGYLLPLLAKEDQNQIIVSVPTKLLQDQLMAGEVAAIQEQFH
                     IACHSLKGPANYLKLDSFADSLDQNDQNRLVNRYKMQLLVWLLETKTGDLDEIKQKQR
                     FAAYFEQLKHDGDIKQSSEFYDYDFWRVSYEKAKTARLLITNHAYFLHRVQDDKDFAR
                     NKVLVFDEAQKLMLQLDQLSRHQLNLTVFLQTIQAKLSNPLPLLEKRLLESLSFELGQ
                     VSSDYYQNKEHQLAHDWSRIAGYAKELTGADYQELQAFFATSDGDYWLSSEKQEEKRV
                     TYLNSASKAFIHFQQLLPETVKTYFVSATLTISSEVTLADLLGFEEYLYHVIEKDKKQ
                     DQLVLVDQEAPIVTEVSDQIYVEAIAKRIESLKQEGYPILVLFNSKKHLLLVSDYLDQ
                     WQVPHLAQEKNGTAYNIKKRFDQGEQTILLGLGSFWEGVDFIQADRMITLIARLPFDN
                     PEDFFVKKMSHYLLEKGKNPFRDYFLPMTILRLKQAIGRTMRRQDQKSVVIILDRRLL
                     TKSYGQVILEGLGQEFLISQQNFHDCLVETDCFLI"
     gene            complement(9139..9903)
                     /locus_tag="VHC05_000871"
     CDS             complement(9139..9903)
                     /locus_tag="VHC05_000871"
                     /EC_number="1.1.1.304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000048144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(S)-acetoin forming diacetyl reductase"
                     /protein_id="HEQ5402194.1"
                     /translation="MSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVD
                     KLSPEDAVAVVADVSKRDQVFDAFQKVVDTFGDLNVVVNNAGVAPTTPLDTITEEQFE
                     KAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFAVRGI
                     TQTLAKDLASEGITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMDQFAKDITLKR
                     LSEPEDVANAVGFLAGDDSNYITGQTIVVDGGMVFH"
     gene            10135..10770
                     /locus_tag="VHC05_000872"
     CDS             10135..10770
                     /locus_tag="VHC05_000872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEQ5402195.1"
                     /translation="MKIYKTINHIAGENTYYLVNDQAVILIDPGSNGQEIIAKIKSFE
                     KPLVAILLTHTHYDHIFSLDLVRDAFDHPPVYVSEKEAAWLSSPDDNLSGLGRHDDII
                     TVIARPAENFFKLKQPYQLNGFEFTVLPTPGHSWGGVSFVFHSDELVVTGDALFRETI
                     GRTDLPTSNFEDLITGIRQELFTLPNHYRVYPGHGPSTTICHEKNANPFFH"
     gene            complement(11080..12009)
                     /locus_tag="VHC05_000873"
     CDS             complement(11080..12009)
                     /locus_tag="VHC05_000873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402196.1"
                     /translation="MIRYFFRHIWESIKNLKRNFWMTFASVSMVAVTLTLVGVFAATL
                     LNIQRVASGVENNVHINTYLQVDSTDAAKVIQNTAGEPVNNDNYHSVYDKIAQIKGVK
                     KITFSSKDEQLKKLQETLGDVWNMYDQDTNPLQDIYLIETQTPKQVKAITKKIRTIEG
                     VEAADYGGINSDKLFKFSTLIQTWGLIGTAMLLFVAVFLISNTIRMTIMSRKRDIEIM
                     RLVGAKNSYIRGPFFFEGAWVGLLGAVLPSLLIYYGYDLVYKHFAQELQRNNLSMYPL
                     DPYVYYLIGALFVIGIMIGSLGSVLSMRRYLKF"
     gene            complement(12002..12694)
                     /gene="ftsE"
                     /locus_tag="VHC05_000874"
     CDS             complement(12002..12694)
                     /gene="ftsE"
                     /locus_tag="VHC05_000874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division ATP-binding protein FtsE"
                     /protein_id="HEQ5402197.1"
                     /translation="MALIEMSGVTKKYRRSTTALRDVNVSVNQGEFVYLVGPSGAGKS
                     TFIKLLYREEQLTTGKLYVGEFNLTKLKARDVPILRRHIGVVFQDYKLLPRKTVFENV
                     AYAMEVIGEKRRHIKKRVPEVLDLVGLKHKMRSFPSQLSGGEQQRVAIARAIVNNPKL
                     LIADEPTGNLDPEISWEIMQLLERINVQGTTILMATHNSHIVNTFRHRVVAIEDGRIV
                     RDEEKGDYGYDD"
     gene            complement(12713..13811)
                     /gene="prfB"
                     /locus_tag="VHC05_000875"
     CDS             complement(join(12713..13738,13740..13811))
                     /gene="prfB"
                     /locus_tag="VHC05_000875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889043.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 2"
                     /protein_id="HEQ5402198.1"
                     /translation="MEVAEIRQKIVENKEKLTSFRRSLDLDRLEEEIALLENHMTEPD
                     FWNDNIAAQKTSQELNELKGKYDTFHNMQELSDETELLLEMLDEDDSLKEELEENLMQ
                     LDKIMGAYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWGDLLLRMYTRFGNANGFKV
                     EVLDYQAGDEAGIKSVTLSFEGPNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFASVE
                     VMPELDDTIEVEVRDDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVSSTVDRT
                     QYGNRDRAMKMLQAKLYQLEQEKKAQEVDALKGDKKEITWGSQIRSYVFTPYTMVKDH
                     RTNFELAQVDKVMDGEINGFIDAYLKWRIED"
     gene            complement(13880..15004)
                     /gene="queG"
                     /locus_tag="VHC05_000876"
     CDS             complement(13880..15004)
                     /gene="queG"
                     /locus_tag="VHC05_000876"
                     /EC_number="1.17.99.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA epoxyqueuosine(34) reductase QueG"
                     /protein_id="HEQ5402199.1"
                     /translation="MTIKAEIKALAKEIGISKIGFTTADNFDYLEKSLRASVEEGRNS
                     GFEHKVIEDRISPESLLESAKTIISIGVAYPHKLPQQPQKTPYKRGKITPSSWGLDYH
                     YVVGEKLDRLSKGIEELCRDFPLQQKAMVDTGALVDTAVAQRAGIGFIGKNGLVISKE
                     YGSYMFLGELITNLEIEPDKPVDYDCGDCRRCLDACPTSCLIGDGSMNAKRCLSFQTQ
                     DKGMMDTEFRKKIKTVIYGCDICQICCPYNKGINNSPATEIDPELAQPELIPFLSLSN
                     GQFKEKFGMIAGSWRGKNILQRNAIIALANAHDKTAVVKLIEIIDKNNNPIHTATAIW
                     ALGEIVKKPNDEMLAFMSHLTLKDEDSRKELELIRRKWQV"
     gene            complement(15358..15450)
                     /locus_tag="VHC05_000877"
     CDS             complement(15358..15450)
                     /locus_tag="VHC05_000877"
                     /inference="COORDINATES: protein motif:HMM:NF018571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402200.1"
                     /translation="MAGDMFNRGHYLDLFLDWLVSKYRRIIILL"
     gene            complement(15695..16345)
                     /locus_tag="VHC05_000878"
     CDS             complement(15695..16345)
                     /locus_tag="VHC05_000878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family phosphatase"
                     /protein_id="HEQ5402201.1"
                     /translation="MIKGIIFDMDGVLFDTEPFYLRRREDFFKTKGIPIDHLNSKDFI
                     GGNLQELWKELLGKNRDDAIVKAITTDYDAYKQAHKPPYQKLLITEVNSCLEQLKKQG
                     IKLAVASNSKRQDVLLALETTQIKDYFEIILAREDVSRGKPYPDIYNKAVQKLGLQKK
                     QLLVVEDSQKGIAAAKAANLTVFAITDYRYGIDQSQADHKIDHLGQLCVKIGCFGS"
     gene            complement(16641..17276)
                     /locus_tag="VHC05_000879"
     CDS             complement(16641..17276)
                     /locus_tag="VHC05_000879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="HEQ5402202.1"
                     /translation="MGKIEILTKLKANRLVLVVRGESSEEALACSLASIEGGIKTIEV
                     TYTNPFASEVIGQLAERFKEDPEVLIGAGTVLDDVTARQAILAGAQLIVGPNFNRAVA
                     LICHRYSIPYLPGCMTVNEVVTALESGVDMVKIFPGSTVGMSFIRAIKSPLPQVEVMV
                     TGGVSSDNLKDWLAAGVDVLGIGGEFNQLASQKQYNLITKKAAHYIKSLRQ"
     gene            complement(17281..18282)
                     /locus_tag="VHC05_000880"
     CDS             complement(17281..18282)
                     /locus_tag="VHC05_000880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HEQ5402203.1"
                     /translation="MSKLLLVGEPLIRVSPNQFQPLTNACDAQLFFGGSEVNIARTLG
                     GFGLEARLFTALPDNPVGHAFHQFLKQSGVDMTLTAWQGNRVGLYYLENGFGCRSSQV
                     YYDRCGSSFSALDKDSLDLAAIFEGISHFHFSGISLALGKKTQDLIEILVREAKKRDI
                     CVSFDLNFRSSMIAVADAKRLFSHFAQYADIIFGMEPLLLDSDDFDMFDRNKADTTMI
                     RERLAGLYQRYQLQAIYHTERSNDAQGSNHFKAYTYDGQFYESCEVTTPVLQRVGSGD
                     AFVAGLLYQLLEGDEKQYNLDFAVATASLKCTVAEDQLYHSAQQVEAVLANQRDVQR"
     gene            complement(18311..18952)
                     /locus_tag="VHC05_000881"
     CDS             complement(18311..18952)
                     /locus_tag="VHC05_000881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RpiB/LacA/LacB family sugar-phosphate isomerase"
                     /protein_id="HEQ5402204.1"
                     /translation="MKIALINENSQAAKNGIIYDALTSVTDKHGYQVFNYGMYGTEGE
                     SQLTYVQNGLLASILLTTKAADFVVTGCGTGVGAMLALNSFPGVTCGFASEPTEAYLF
                     SQINGGNALSIPFAKGFGWGAELNLTLIFERLFAEPMGGGYPKERAIPEQRNARILSD
                     LKKITYRDLLAIVKDIDQDFLKETISGAHFKEYFFANAEPSELVTYLKSVLEQ"
     gene            complement(18977..19771)
                     /locus_tag="VHC05_000882"
     CDS             complement(18977..19771)
                     /locus_tag="VHC05_000882"
                     /EC_number="1.1.1.69"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012766735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gluconate 5-dehydrogenase"
                     /protein_id="HEQ5402205.1"
                     /translation="MENMFSLQGKIALITGASYGIGFEIAKAYAQAGATIVFNDIKQE
                     LVDKGLAAYRELGIEAHGYVCDVTDEVGIQQMVSQIEDEVGVIDILVNNAGIIRRTPM
                     LEMAAEDFRQVIDIDLNAPFIVSKAVLPSMIAKGHGKIINICSMMSELGRETVSAYAA
                     AKGGLKMLTKNIASEFGEANIQCNGIGPGYIATPQTAPLRERQADGSRHPFDQFIIAK
                     TPAARWGTTEDLAGPAVFLASDASNFVNGHILYVDGGILAYIGKQP"
     gene            20105..20542
                     /locus_tag="VHC05_000883"
     CDS             20105..20542
                     /locus_tag="VHC05_000883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEQ5402206.1"
                     /translation="MIAIIVMGHGHFASGIVSALELIAGKQEKVTAIDFTAEMTAADV
                     QDQLSRALIPEEETLVLCDLLGGTPFKVAATLMESLPNTTCNVLSGLNLAMLIEASFA
                     RQTAASFDDLVSGLIICSKEGIVDWKTLSQQEDGATDDELGGI"
     gene            20542..21741
                     /locus_tag="VHC05_000884"
     CDS             20542..21741
                     /locus_tag="VHC05_000884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="HEQ5402207.1"
                     /translation="MTRLLKTIALEPIKQPERFTKEDFLSQEDITQALDLALKQVRLN
                     MDYFKEDFPTPATKDNQYAIMDNTEWTNAFWTGCLWLAYEYSGDDAIKALAQANDLSF
                     LDRVTRDIELDHHDLGFLYTPSCMAEWKLLKTPEAREAALKAADKLVQRYQDKGGFIQ
                     AWGELGKKQDYRLIIDCLLNIQLLFFASQETGDNRYPDMAINHFYASANHVIRDDASA
                     YHTFYFDPETGDPVKGVTRQGYSDDSAWARGQAWGIYGIPLTYRFLKEPELIQLFKGM
                     THYFLNRLPKDQVSYWDLIFGDGSEQSRDSSATAIAVCGIHEMLKTLPDHDPDKKTYE
                     AAMHSMLRALIKDYANKDLNPGAPLLLHGVYSWHSGKGVDEGNIWGDYYYLEALLRFY
                     KDWNPYW"
     gene            21777..22265
                     /locus_tag="VHC05_000885"
     CDS             21777..22265
                     /locus_tag="VHC05_000885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system
                     mannose/fructose/N-acetylgalactosamine-transporter subunit
                     IIB"
                     /protein_id="HEQ5402208.1"
                     /translation="MTQPNIIMTRVDERLIHGQGQLWVKYLNCNTVIVANDAVSEDKI
                     QQSLMKTVIPSSIAIRFFSIQKVIDIIHKASPAQSIFIVVKDLQDAKRLVEGGVPITE
                     INIGNIHKTDDKVAITQFISLGETDKSAIRCLAHDHQVVFNTKTTPAGNSASDVDILD
                     YI"
     gene            22284..23066
                     /locus_tag="VHC05_000886"
     CDS             22284..23066
                     /locus_tag="VHC05_000886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEQ5402209.1"
                     /translation="MDINLLQALLIGLWTAFCFSGMLLGIYTNRCIILSFGVGMILGD
                     LPTALSMGAISELAYMGFGVGAGGTVPPNPIGPGIFGTLMAITSAGKVTPEAALALST
                     PIAVAIQFLQTFAYTAFAGAPETAKKQLQKGNIRGFKFAANGTIWAFAFIGLGLGLLG
                     ALSMDTLLHLVDYIPPVLLNGLTVAGKMLPAIGFAMILSVMAKKELIPFVLIGYVCAA
                     YLQIPTIGIAIIGIIFALNEFYNKPKQVDATTVQGGQQDDWI"
     gene            23053..23874
                     /locus_tag="VHC05_000887"
     CDS             23053..23874
                     /locus_tag="VHC05_000887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEQ5402210.1"
                     /translation="MTGSNKLTKKDYLKTALRAFFLQNGFNYSNYQGIGYANVIYPAL
                     KKHFGSDKKGLYQALEDNCEFYNTNPHFLPFITSLHLVMLENDRPEEETRNIKMALMG
                     PLAGIGDSLSQFCLAPLFSTIAASLASDGLVLGPIFFFLAMNIILTAIKIGSGLYGYK
                     VGTSFIDKLSEQMAVVSRMANIVGVTVIAGLAATSVKITVPITFAAGKVDAANTAQKF
                     VTIQGMLDKIAPALLPALFTLLMYYLIKNKKWTTYKLVLLTVLIGIIGSWLGILA"
     gene            23961..25868
                     /locus_tag="VHC05_000888"
     CDS             23961..25868
                     /locus_tag="VHC05_000888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alginate lyase family protein"
                     /protein_id="HEQ5402211.1"
                     /translation="MSLAFTRFKETVNPDFCRNYLLDYQTDSYADQKRIADLLLTNTF
                     LFEDNWDMEPCHIPYHLDPITWQEAVTDDPEWNFMLNRQTYLQKLILVYLVERDERYL
                     LKAKSFILNWIESAIPLDPKGLATRTLDTGIRCFAWVKCLIYLNLFNALTKQEESLIL
                     ASLEKQLQFLHANYLDKYSLSNWGILQTTAILLADAYYGSDLDIAAATAFARKELTQQ
                     IALQILEDGSQFEQSTMYHVEVLKALLELTALVPDYLPQLRPTLLAMSDYLLKMTGPD
                     HKQIPLGDSDFTDTRDILTLAATILEEPHLKAAAFPTLDIDSLLLLGEKGVHTFEQLP
                     VQTLPTFAHHFEHSGHITINQENYYLFFKNGPIGSSHTHSDQNSLCLYYKGQPLFCDA
                     GRYTYKEEPLRYALKSASHHSTAFLKEQLPEQIDSSWAYLSYPKSNYCHLRQNGHVYF
                     IEGSYQTQFSDRNNYQHDRQILILPPGMFLIIDTIQAQGNHCLVSQFILDNHLDVKTD
                     HLSDLRLISDCPFTIEETILSKKYNQYLTSHKFIKRKPFKDKGCTSTLLVPDDTKVTP
                     LTPLQTGKRNPIETALSWHLKGKQFDYSICVLQEDLIKGEKLVLLNGHKIRGKVVVIN
                     HITNEIIRLKH"
     gene            25932..26927
                     /locus_tag="VHC05_000889"
     CDS             25932..26927
                     /locus_tag="VHC05_000889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEQ5402212.1"
                     /translation="MQRKVTIKDIAELAKTSKTTVSFYLNGRFDKMSEETKNRIKSTI
                     EATNYKPSIAARSLNAKSTKLIGVVIGDITNSFSNQIVKGIESKAQEFGYQIIIGNSN
                     YDPSREDELIEKMLNLGVDGFIIQPTSNFRKYSRIIDIKKKKVVFFDSQLYEHRTNWV
                     KTNNYDAVYDTIQQCIDKGYEHFIMITGNPNLLSTRIERASGFIDVLEANHLTHQEMI
                     IDENQTSSEAIAQFLQGSLTKKSLVFVPNCWALPKVFTAMKSLKFNIPEIGLVGFDNI
                     EWTKFSSPTLTTIIQPAYEEGEQATKILIDDIEGHSQEAKQQIFDCQVNWQESTF"
     gene            complement(27011..29692)
                     /locus_tag="VHC05_000890"
     CDS             complement(27011..29692)
                     /locus_tag="VHC05_000890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HEQ5402213.1"
                     /translation="MSKEQRHEAFYTQSEETVLAQLETSREGLTSAQAKERLAEYGRN
                     ELDEGEKRSLFMKFLDQFKDLMIIILIVAALLSVLTEGMEGLTDAIIILAVVILNAAF
                     GVYQEGQAEAAIEALKSMSSPLARIRRDGHVTEIDSKELVPGDIVLLEAGDVVPADLR
                     LLEANSLKIEEAALTGESVPVEKDLSTAVSEDAGIGDRVNMGYQNSNVTYGRGIGVIT
                     NTGMYTEVGHIAGMLANADETDTPLKQNLDNLSKILTYAILVIAAVTFAVGVFLRGQH
                     PLEGLMTSVALAVAAIPEGLPAIVTVVLSLGTQVLAKRNAIIRKLPAVETLGSTEIIA
                     SDKTGTLTMNQMTVEKVYTNGTLQSSSADIAFDNTTLRVMNFANDTKVDPSGKLIGDP
                     TETALVQFGLDHNFDVREAMVAEPRVAELPFDSDRKLMSTIHKQADGKYFIAVKGAPD
                     QLLKRVTQIEENGQIRPITDADKKTILDTNKSLAKQALRVLMMAYKYSDALPTLETEI
                     VEANLVFSGLVGMIDPERPEAAQAVKVAKEAGIRPIMITGDHQDTAKAIAKRLGIIEE
                     DGVDHVFTGAELNELSDEEFQKVFKQYSVYARVSPEHKVRIVKAWQNEGKVVAMTGDG
                     VNDAPSLKTADIGIGMGITGTEVSKGASDMVLADDNFATIIVAVEEGRKVFSNIQKTI
                     QYLLSANMAEVFTIFLATLFGWDVLQPVHLLWINLVTDTLPAIALGVEPAEPGVMKHK
                     PRGRKSSFFDGGVKEAILYQGAFQTILVLGVYGFALMFPEHTSYHDVHADALTMAYVT
                     LGLIQLVHAYNVKSVYQSIFTVGLFKNKLFNYSIPVAFVALMATVVVPGFNQFFHVTH
                     LTITQWLVVIIGSLLMVVLVELVKAVQRSLGQDEKAI"
     gene            complement(29923..30309)
                     /locus_tag="VHC05_000891"
     CDS             complement(29923..30309)
                     /locus_tag="VHC05_000891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1934 domain-containing protein"
                     /protein_id="HEQ5402214.1"
                     /translation="MKLQLTNHIRFGDETEIIQEIHDCEWREKGDYQYLIYQNTDKEK
                     VVIKYNETELTMSRFSNPQSIMKFFAGKKVLIALPTPMGVQQFLTDTSHYHLDCSCQK
                     LDLHYHLLQAQTEMLFASYHLELSWD"
     gene            30400..31701
                     /locus_tag="VHC05_000892"
     CDS             30400..31701
                     /locus_tag="VHC05_000892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HEQ5402215.1"
                     /translation="MNEKVFRDPVHNYIHIDNPLIYDLINTKEFQRLRRIKQVPTTAF
                     TFHGAEHSRFSHCLGVYEIARRVTAIFEEKYADIWNKDESLVTMTAALLHDIGHGAYS
                     HTFEALFHTDHEAFTQEIITNPETEINAILVRHAPDFPDKVASVINHTYPNKQVVQLI
                     SSQIDCDRMDYLLRDSYFSAANYGQFDLMRILRVIRPVEDGIVFEHSGMHAVEDYIVS
                     RFQMYMQVYFHPASRAVELILQNLLKRAQHLYPEQQAYFQKTAPGLIPFFEKKANLAD
                     YIALDDGVMNTYFQVWMTSEDHILSDLASRFINRKILKSVTFDQDSRGELERLRQLVE
                     SVGFDPDYYTGIHINFDLPYDIYRPELENPRTQIEMMQKDGSLAELSQLSPIVKALTG
                     TTYGDRRFYFPKEMLELDDLFAPSKETFMSYISNGHFHFSQ"
     gene            32156..32965
                     /gene="yidA"
                     /locus_tag="VHC05_000893"
     CDS             32156..32965
                     /gene="yidA"
                     /locus_tag="VHC05_000893"
                     /EC_number="3.1.3.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985513.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-phosphatase"
                     /protein_id="HEQ5402216.1"
                     /translation="MSIKLVAVDIDGTLLTDDRRITDDVFQAVQEAKAQGVHVVIATG
                     RPIAGVISLLEQLELNHKGNHVITFNGGLVQDAETGEEIVKELMTYDDYLETEFMSRK
                     LGVHMHAITKEGIYTANRNIGKYTVHESTLVNMPIFYRTPEEMTNKEIIKMMMIDEPD
                     LLDAAIKQIPQHFFDKYTIVKSTPFYLEFMPKTVSKGNAIKHLAKKLGLDMSQTMAIG
                     DAENDRAMLEVVANPVVMENGVPELKKIAKYITKSNNDSGVAHAIRKWVLN"
     gene            32965..34191
                     /locus_tag="VHC05_000894"
     CDS             32965..34191
                     /locus_tag="VHC05_000894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipid II:glycine glycyltransferase FemX"
                     /protein_id="HEQ5402217.1"
                     /translation="MYTYKIGISPEEHDQFVLAQPQAGLLQSSKWGKVKDNWKHERIS
                     FYENGVQVAAAACLIRKLPLGFTMIYIPRGPIMDYANFELLDFVIKTLKTFGKSKRAL
                     FVKIDPSLVIKQTLEGKESKENDVALSIIAFLKKLGVEWSGRTKELEDTIQPRIQANI
                     YAKDFDFDSLPKKAKQSIRTATNKGVNVTIGGSELLDDFSALMKKTENRKGIILRGKS
                     YYQKLLDIYAGQSYITMASLDLPEQKKTLIQQLDKALAEQVRLTDKSKPSKVAENQKT
                     IARLQKDLTILSEQLAAGKTRIPLAATLTLIYGETSENLYAGMDDDYRNYQAPLLTWY
                     ETAKEAFKRGCRWHNLGGVENQQDGGLYHFKARLNPTIEEFAGEFNIPVGLVSSLAIL
                     TYNLRKKLRSTTNGTN"
     gene            34178..35413
                     /locus_tag="VHC05_000895"
     CDS             34178..35413
                     /locus_tag="VHC05_000895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyltransferase"
                     /protein_id="HEQ5402218.1"
                     /translation="MALIEISQEQFDHYCHSLVHHSFIQTSEMASLMAKRGAKPQFLG
                     LEKDGELKVAAMVFSQKVAGGWRMELNAGPNTNHPEELEHFYTQLKDYAKQKDVIELI
                     LKPYDNYQSFDTDGIPISHPNTDLISLLTALGYKHDGLKTGYPEGEPVWHYVKKLEGI
                     DSSHLTHSFSKKGKALIKKANTFGIKLRQLKRDELHHFKEITEATSDRRDYLDKSLSY
                     YQDFYDSFGDSCEFMVATLNFEDYLNNLKQRQLQLATSINKVKGDLGKNPHSEKKQNR
                     LKELSSQFETFQVRISEALHFLEEYGTKDVFLAGSLFIYTEQEAVYLFSGSYPKFNKF
                     YSPALLQEHAMLKAIHKGIKQYNFLGITGKFDGSDGVLRFKQNFNGFILQKPGTFKCY
                     PFPIKYHFIRLAKKLLNRY"
     gene            complement(35512..36270)
                     /locus_tag="VHC05_000896"
     CDS             complement(35512..36270)
                     /locus_tag="VHC05_000896"
                     /EC_number="5.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012515922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="triose-phosphate isomerase"
                     /protein_id="HEQ5402219.1"
                     /translation="MLRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAP
                     AVDLVTTIEAAKDSVLKVAAQNCYFENTGAFTGETSPKVLAEMGADYVVIGHSERRDY
                     FHETDEDINKKAKAIFANGLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQV
                     ASLVLAYEPIWAIGTGKSATQDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPE
                     NVKDYMACPDVDGALVGGASLEADSFLALLDFLN"
BASE COUNT        11186 a         7787 c         6412 g        10942 t
ORIGIN      
        1 atattaatga tttgattgac ctaccaaaac taaaaaaaga catcgaagaa ctcaatcatt
       61 taaaagatga ttataacaaa gcaattaaat tgaattattt agacaagaaa aacgaagact
      121 ctcttggaat gctgatggat aacattgaca ttagaaaatc ttcgtatgat gttcaatcta
      181 ggatagttaa gcaattgata gatagagtcg aggttactat ggataacatc gatattattt
      241 ttaagtttta aaagcattat ttaggcacta caacgagtat agttgtacat gaatcttgta
      301 ttttattgtt gcgcataata gtctccttta cacacgatat tatccctttt atcatatcac
      361 agaacatcag acacttcaaa aaaacaatgg aaaacgactt ttagacagaa aaatcgtatg
      421 aacaaaggct catacgataa aaatgttcta taagtcatct gcaattttat tgattttacg
      481 caagcgatgg ttgaccccgc tcttggtgat tgggaactca agggcatcag caacttgttg
      541 aatggaatag tctggatgct taacccgaag ctgggctacc tgttgcaatt caatcggtaa
      601 actttctaaa ccaattgtgt ccatgatttt aataatatta ttaatagttt tcatgctagc
      661 actgatagtt ttggcaatat tagctgtttc tgcattattg gcacggttaa tatcatttcg
      721 agcttctcga agtaatttga tggcttcaaa gtcttctttg caggacatgg caccaattat
      781 aattaaaaag tccatgatat cttctgcctt ttgcacataa gtaactgcac cgcttttatg
      841 ctcgatggtt ttggcatcta gcataaattt ttgcatgagt tgagctaaat cttgagcatg
      901 atcaagataa actgaataga tttctaactg atacttgcct gactcaggat ctctgatgct
      961 acctgccgct agaaaagccc ctttaagata agaacggcca gcattatcgt ctgataaaac
     1021 ctgaggttcg atgcctgttt ccagaccaaa aaaggagtcc gctaatttca aatcggctaa
     1081 aatggtttcc acaccttgct caacatagac ggtgtaaaca cggtttttgc gcaggttcgt
     1141 cttttgatga tacctgattt ctggcacgat aacataggcg tcttcaataa gagaataaat
     1201 gtagcgggca attttagcat tttcagtggt aatggataaa tgaaggcttt ggtgagctaa
     1261 gcccaagctg cctgataatt tgataatggc ggccaattca ttgttgtcac ctgtggacaa
     1321 gtgaattaat tcctctttga ccttggttgt aaaactcatt gcttgactat cctcactaaa
     1381 ttcattaatt cttccaccac taagttacca tcgtgaaaag ctccgccatt ctccaaccgt
     1441 aaaaaataag acgaaatcac acgcttagca gccctgcaaa ggccagcaaa gtcgtgatca
     1501 acctgaacga ggtattcatc aaatttgtta gaattcatgt aagcctgcgg caccttagcc
     1561 acatttacca aaaccgtatc aatcaaatct cttcctaagt gctgatttaa aacagccaca
     1621 tggtctgcat ctgaaaattg ttctgtttca ccatactggg tcatgatatt acaaatatac
     1681 accacttctg ctttagtctg gcgcaaagct tctttaattt ctggaatgac caaattaggt
     1741 aaaatagagg taaacagtga gcctggtccc aagacaatca tgtcactttc tagaatagcc
     1801 tcaaccacct tacgactggc ctgaggcttt tggtcgttgt aggtgttggt cacatagaca
     1861 tggtcaatca tgccttggta tttggcaata gaactttctc ctgctacttc atgcccatct
     1921 ttaaaaacag catgaagggt caaggcctgc tcgctagagg ggtaaatttt acctgtaata
     1981 tggaaaaatt tggttaaaat ttgaatggca ttgtaggttg agccttgcat ttcagagata
     2041 ccagcaataa tgagattgcc tagagggtga ccagccaagg ctccatcact ctcgttaaaa
     2101 cggtattgga aaacccgctc ataaaatttt ggcatgtcac tcatcgctaa caagacattc
     2161 cgtaagtctc ctggcggggc taattgcatg gcattacgaa gttctcctga ggaaccacca
     2221 tcatctgcaa cagtgaccac agcagtaata tcaactgctt cattacgaag gctttttagg
     2281 ataatggaga tgccagtacc cccacctata acagtcattt taggattttt catgaacgat
     2341 tcaccgtttc cttacgacga ttttgatcac gatggctttc attaaccgac caatctgttg
     2401 ccagactttc tgccaagcaa tgggcaaagg caacgctgcg gtgttggcct cctgtgcagc
     2461 caatagccac cgtcaagaca gacttccctt ctttttggta agccggtaag atagggacaa
     2521 taaggtttaa caaatgcttg taaaacacct ctgattctgg gtgagacatc acataattaa
     2581 aaacgtcctc atctagtcct gttttttcac gaagctctac ctgataataa ggattgggta
     2641 gaaaacgcac atcaaaaacc aaatccgcat ccaaaggaag accatatttg aacccaaagc
     2701 tcatcacttc aatacggaaa gaggcttgat tagacccttc agaaaactgg tctgaaatgg
     2761 ttttacgcaa ttgtctaggg gtcaattttg ttgtatccac aacatgttgg ctcatgcttt
     2821 tcaaaggaga taggagttct ctttccaatc gaataccatc aagcacacga ccgtccgcag
     2881 ccaaagggtg gctccgtctg gtttctttat agcgtgacac caattctcca tctgttgcat
     2941 ccaaaaaaag aatccgaaaa tcaatgctag gattgctttc aatactatct aaggtagaat
     3001 taatttcctt gaaaaacaaa cgacttctca tatcgacaac caaagccacc ctacgatttt
     3061 cattggtttg ttcaattaat tctaaaaatt ttggaaccaa ggctgggggc atattatcaa
     3121 tggtaaagta gcctagatcc tcaaaagact gaatggcaac tgtttttcca gcgccgctca
     3181 ttcctgtcac aataactaaa ttaatgtgtt tgtctgacat ttacaatttc cctttctcta
     3241 tcgaaccgtc caccttcatt ataccacata cataagaaac ctaagaagtg aaaaagtggt
     3301 aacacatttt gaactgtaaa aatcagctaa ttttaataat aactcccgta gctctcctat
     3361 tataggaata gacgagacct ttttagtatc aaatgagagt gtctatttca taatcgtagt
     3421 ccaaatactt gtctataaaa tatcccttga gcaaggctat attgtcttat ctgctaactg
     3481 atctactaaa cttccaaaat ttatcttcac aaaggatgta ggttcaaact ctactatttc
     3541 ttatctctcc tttaggacat attgattttt ttataacaca ctcacttctt accaatacaa
     3601 aaagttcata gatgacatga actttttgta ttattagggt ctaatccgat gtaacatacg
     3661 tgggaatgga atagcttcgc gaatatgttt ggtaccagca acaaaagtta ccatacgttc
     3721 aatacctata ccaaaaccgc catgaggaac agagccatat ttacgaaggt caaggtaaaa
     3781 gtcatattct gatttatcca tacctagttc atccatttta gccacaagag tatcgtagtt
     3841 gtcttcacgc attgagccgc caatgatctc tccataacct tctggagcta aaagatcagc
     3901 acaaagaacg cgttctggat ttccaggaac tggtttcata taaaatgctt taaagcttgc
     3961 tgggtaattc actacaaatg tcggtactcc aaagtaatta gaaatccaag tttcatgtgg
     4021 ggaaccaaag tcatcaccat gctctaaatg ttcataatct gtatcttcat ctgcttcatg
     4081 ctcttgaaga agtgtaatag catcatcata agaaacacgc ttgaatggct ctgtgatata
     4141 acgtttgaga gcctcaacat cacgttctaa aatatcaagt gcttgaggcg cacgatctag
     4201 aacgccttgg atcaacgctt taacataagc ttcttgaagg tcaagtgatt cctcatgtga
     4261 caagaaagaa tactcagcat ccatcatcca aaattctgtt aaatggcgac gtgttttaga
     4321 tttttcagca cgaaagactg gaccaaagtc gaaaactcgg cctagagcca ttgctccagc
     4381 ttcaaggtat aattgaccag attggctaag aaatgctggt ttcccaaaat agtctgtttc
     4441 gaataactct gttgaatctt ctgctgcatt ttctgataaa attgggctat caaatttgat
     4501 aaaaccattt tggtcaaaga attcataagt tgcataaata atagcgttac gaatttgcat
     4561 aacagccatt tgtttacgag aacgcaacca aagatgacgg ttgtccatca agaagtctgt
     4621 cccatgctct ttaggagtta taggatattc atgtgactct ccaatgattt caaggtcagt
     4681 aatatcaagc tcatagccaa atttagaacg ctcatcctct ttaacaatcc ctgttacata
     4741 aacagatgtt tcttggttga gacgtttaat aacgtcaaat ttttcatgac ctgattcttc
     4801 accatatttt tcaatgaagt ttggtttaaa agcgacacct tggaaaaaag cagaaccatc
     4861 gcgtaactgt acaaacgcaa tcttaccttt acctgatttg ttagcaaccc aagcaccaat
     4921 agtaacttct tgaccaacat aatctttaac atcaacaatt gaaataagtt tttttgacat
     4981 aagtttctct ctatttttat ttaattaatt tcattacttt ccataaagac atgcagtcta
     5041 cgaacagctt ctttaagggt ttcgatatct gtagcataac tcagacgaac attttccggt
     5101 gcgccaaagc ctgctccact cacaacagct aatccgactt cctctaaaat agcattagca
     5161 aagcttgtca catcggaaaa acctgtcatt tccatggctt tcttaacgtt tggaaagaag
     5221 taaaaagctc cttgtggttt aacaacctca aacccaggga cctgacacaa caatggataa
     5281 atgatattaa ggcgctcttc aaacgctaat cgcatctctt caagtgatga ctgactacca
     5341 cagaaagcct cgatagcagc atattgtgaa acggttgtca ggttagaggt agtctgcccg
     5401 atgatcttac tcattgccga aatgatctct ggttcacctg ctgcaaaacc aacccgccag
     5461 cctgtcatgg cataactttt agccacgcca ttgaccgtaa tggtttgacg acgaatcgct
     5521 tctgagagtg ttgaaatagg aacaaactga ttgccgttat agactaagga cccgtaaata
     5581 tcatctgcca gaataagaat atcgttgtgc accgcccatt ctccaatggc ccttaattcc
     5641 tcagcaccat aaatcatacc tgttggattg gaaggggaat tgataaggac aactttagtc
     5701 ttacttgtcc ttgctctttc cagctggtca acagttacct tgaattgatt ttcttctagt
     5761 ccttgaacga agatcggctg accttctgcc atttttactt ggtcagaata agatacccaa
     5821 tatggtgttg gaatgagaac ttggtcacca ggatttaaaa cagccataaa aaaggcataa
     5881 aggatgaact tggcacctgt tcctgccaca atctgatcag gagacaagtg atacccatac
     5941 tgatttttca ggtatgtggc aatcgcagct tttaattctg gaagcccaga agcatttgta
     6001 taaaagctag ccgtaccatt ttgaatagat tcaatcgcct tgtcttgaat gtgcttaggt
     6061 gtaaaaaaat ctggttctcc taaagttaaa ttcagtacat cacggccctg cgctttcaaa
     6121 gccttagctc tagcacctgc agccagagta acactctctt tcatttctaa aactcgcttt
     6181 gatagtttgg gcatcgtatc tcctttttat cgacttctta tcttcagatt aattaatgat
     6241 caacagatca ttttttcata atctacggtt tcagttttac caatactcgc tactgatcgc
     6301 acgaactatg acaagctgtt ttgatagcaa ctgacactaa tgaaaagaac agtaattggg
     6361 tttactaaaa ccaaaaattt gttcatttat tgtccttatc aaaaaaaaca attcgaaaac
     6421 atttgaacag ttgtctaaaa gagcataata aaagttcaaa ctaatttaaa tgttagttga
     6481 ttgtgcttaa cgccattaaa aatttttctg atataataga tcctttccat tatatcagaa
     6541 aacagtccgt ttctactaga caatcgtgaa aattttgttg agaaatcaaa aattcctgac
     6601 cgagaccttc caaaataact tgtccatagg actttgtaag gagacgacga tccaaaataa
     6661 taaccactga cttttgatct tgtcgacgca tcgtgcgacc aatagcctgt tttaatcgca
     6721 aaatagtcat tggcaagaag taatctctga aaggattttt acctttttcc aatagataat
     6781 gactcatttt cttaacaaag aaatcctctg ggttatcaaa gggcaatcgt gcgataaggg
     6841 taatcatacg atccgcttga ataaaatcaa ctccttccca aaaagaacct aaaccaagca
     6901 aaatagtttg ctctccttga tcaaaccgtt ttttaatatt ataagctgtt ccattctttt
     6961 cctgcgctaa gtgaggcacc tgccattggt ctagatagtc tgaaaccaac agcaagtgtt
     7021 ttttagaatt aaaaagcact aaaataggat aaccctcttg cttcaagctt tcgattcgtt
     7081 ttgcaattgc ttccacatag atttggtcac tgacttctgt cacgataggc gcctcttgat
     7141 caacaagcac caactggtct tgctttttat ccttttcaat gacatgatag agatactctt
     7201 caaaacctaa taggtctgcc aaggttactt ctgagctgat ggttaaagtg gcagaaacaa
     7261 aataagtttt caccgtttct ggtaagagct gttggaaatg aataaatgcc ttactagcac
     7321 tgtttagata agtcacccgc ttctcctctt gcttttcgct actaagccag tagtcaccat
     7381 ctgaggtagc aaaaaaggct tgtaactctt gataatctgc tcctgttaat tctttggcgt
     7441 agccagctat acgagaccaa tcatgagcaa gctggtgctc tttattttga tagtaatcac
     7501 ttgacacttg tcccagttca aacgacaagc tttccaataa gcgtttttct aaaagaggta
     7561 aagggttgct taacttggcc tgtattgttt gtaaaaaaac cgtcaggtta agctgatgac
     7621 gtgataattg atctaattgg agcatcagtt tttgggcctc atcaaagacc aagaccttgt
     7681 ttctagcaaa gtccttgtca tcttgaacac ggtgtaaaaa ataagcatgg ttggtaatca
     7741 ggagacgggc tgttttggct ttttcataac taactctcca aaaatcgtaa tcgtaaaatt
     7801 cagaagactg cttaatgtct ccatcgtgct taagctgctc aaaataagct gcaaagcgct
     7861 gcttttgttt gatttcgtca aggtctcctg tcttagtttc taagagccaa accaataatt
     7921 gcattttata acgattcacc aaacggttct ggtcattttg gtccaaacta tctgcaaagc
     7981 tatctagctt taggtaattg gcgggccctt ttaaactatg gcaggcgatg tgaaattgtt
     8041 cttgaatagc agctacttca ccagccatta attggtcttg aagaagtttg gtgggcacac
     8101 tgacaatgat ttggttttga tcttcttttg ccaaaagggg tagcaggtag ccgtaggttt
     8161 ttccaatacc tgtctgagct tcaataaaac tagctactcc ctgatggtaa tcttcgtcaa
     8221 ttaactgagc aaattgagtc tgtttaggcc tttcttccag acccaatagt gctatattaa
     8281 tagggaagct ttttgatatt tgataagact tgagagcttt cgagcccttt ggtaagagaa
     8341 tctgtctgat tttaatgtat ttgttgggat cataaggttt ggctttggct aatccttctt
     8401 gaatgaccat tgctgtttca aatagcaggc tatctgaata gactaataag ctttctaagc
     8461 actcaattgg aaggctctca attttttgta aaagtcttaa aaacagtata gctgtagctc
     8521 ttgcatctgc aatagcagta tgagcttctg ccaaatcaat attgagctgc ctagataggt
     8581 gaccaaggtt atacttttca aagcgaggga aaaatagttg ggctaattca acagtatcaa
     8641 cacgtggtat tgttaactca tatccttcca aaaaaagagc ttctgccaat aaatttgcat
     8701 cgaactttac attgtgggca acaaaaatac aatcttcaat caattgataa atgtgatgcg
     8761 ccacttgacc aaaatccgga gctttagcca actgcttatc cgtaatacct gtcaaatgaa
     8821 caatatgctc atctaaagat tcatgaggat taacatctgt ttcataacta tcaataattt
     8881 tatttccttg gataataaca atcccaacct gaataataga agcattggga cctgctccag
     8941 tagcctccaa gtcaactact gcatattttc taagtttttt ctgggtcata gtaagtctat
     9001 tatagcacgc tatatctata aaacaaaaca tgactatatc tcaaaggtgc catcactcca
     9061 ataaccaaga taggataatt ttttaagaag tataaaaaac actgtgagtt tcactcacag
     9121 tgtcagtatt aatcattttt aatggaatac cataccacca tcgacaacta ttgtttgtcc
     9181 agtgatataa tttgaatcat ctcccgctag gaagcctact gcattagcaa catcttctgg
     9241 ttcagacaag cgtttcaaag tgatatcttt tgcaaattga tccatacccc attcatcatc
     9301 tttgcctgca tttttaccaa cttcatgggc aatatcaaac atcataggtg ttttaacaat
     9361 acctggtgcg taagcattga ctgtgattcc ttctgatgcc aaatcctttg ccaaagtctg
     9421 tgtaatacca cgaactgcaa attttgtacc accataaaca gtcaaattag gattcccttc
     9481 acatcctgct tgtgatgttg catttataat ttttccgcca tgacctaatt ctctaaaatg
     9541 tttttgagct gcttggcttc cccaaatcgt tcctccgaca ttgattgcaa aagccttttc
     9601 aaactgctct tcagtaatcg tgtcaagagg ggttgttggg gcaacacctg cattgttaac
     9661 aacaacattc aaatcaccaa aagtatctac aactttttgg aaagcatcaa aaacttggtc
     9721 acgttttgaa acatctgcta caactgcaac agcatcctca ggtgatagtt tatcaaccgc
     9781 agcctgagca gtctcttcat tatagtctaa aatgcctatt ttaaagccgt ctgcatgaag
     9841 acgtttcgca atagcaaatc caattccttg accagcacca gtaacaatag caacttttga
     9901 catatcttcc acctcatatt ttttagtcaa ccgattaggt tgctctcaaa aagtcagtgt
     9961 tcttaaacta agttcagctt taggcttggc ttattgatta cctttatgat acacctttat
    10021 gaaaacggtg tcaataaatt gctgtgagat ctcatatttt ctgaaactaa ttgccattta
    10081 ttttccgcca ctcttttttt taacaaagcc ttgatttttt ggtacactat ccttatgaaa
    10141 atctataaaa caataaacca cattgctggt gaaaatactt attacctcgt taatgatcaa
    10201 gctgttatcc tcattgatcc aggaagtaac ggccaagaaa tcattgctaa aattaaatcc
    10261 tttgaaaaac ctttagtggc tatcctctta acgcatactc actatgatca tatttttagt
    10321 ttagatttgg tcagagatgc ttttgatcat ccacctgttt atgtttcaga aaaagaagcc
    10381 gcttggctat cttccccaga tgataattta tctggcttag gccgtcatga tgatatcatt
    10441 actgttatag caagaccggc agagaacttt tttaaattaa agcaacccta tcaactaaat
    10501 ggttttgaat tcacagtttt accaacacct ggtcattctt ggggaggagt ctcatttgtt
    10561 ttccactcag atgaattagt cgttactggc gatgctctat ttcgtgaaac tatcggtcgt
    10621 actgacttac ctaccagtaa ctttgaggac ctcattactg gtattcgcca agaactattc
    10681 accttaccta atcattaccg agtttatcct gggcatggtc cttctactac catttgtcac
    10741 gaaaaaaatg ctaacccctt ttttcattga catagctatt ttagatactg tttgaggtta
    10801 tcctaaaact gaaatcatag tattttacta aaaaagagcc actaaatttt gaatgacacc
    10861 ccaaaagtta gatacatcaa acatctaact tttggggtgc ttttcttctc ttgaaacctt
    10921 agaaactgct attttaaact atattgccta ttacaaataa acaaatgaat caaaacaaaa
    10981 tgaaaaggac cagtcctgtg caatacaaaa cgaagtcctt ggaataacat aagaggtcca
    11041 acttttgggg gtcgctacgt ttcgtcagca gcgctttttt tagaatttta aataacgtct
    11101 catagaaagc actgaaccaa gcgaaccaat cataatacct atgacaaaca aagcaccaat
    11161 caggtaatat acataaggat caagcggata catcgagaga ttattacgtt gtaattcttg
    11221 tgcaaaatgc ttataaacaa gatcatatcc ataataaatc agaagagatg gtaaaacagc
    11281 tcctaacaag ccaacccaag ccccttcaaa aaagaaaggc cctcgaatat aagaattttt
    11341 agcaccaact aaccgcataa tttcaatgtc gcgtttacga gacataatag tcatacgaat
    11401 agtgtttgaa atgagaaaga cagctacaaa taatagcatt gctgttccga tcaaccccca
    11461 agtttgaatt aatgttgaaa acttaaatag tttatcggag ttaatccctc cataatctgc
    11521 ggcttctacg ccttcaatcg ttctgatctt tttagtgatc gccttaactt gtttaggcgt
    11581 ctgggtctca ataagataga tatcttggag cggattagtg tcttggtcat acatattcca
    11641 aacatcacct aaggtttctt gcaatttttt caattgttca tccttgctag aaaatgtaat
    11701 ctttttgaca ccttttatct gagcaatttt gtcgtaaaca ctgtggtagt tatcgttatt
    11761 aacaggttca ccggcagtat tttgaataac ttttgcagca tcagttgaat caacttgtaa
    11821 gtaggtattg atatggacat tattttcaac acccgaagca acacgctgta tattcaacaa
    11881 tgtcgccgca aaaacaccaa ctaaagtcaa tgtaacagcc accatactaa ctgaagcaaa
    11941 tgtcatccaa aagttgcgtt taagattttt aatggattcc caaatatgac ggaaaaagta
    12001 tctaatcatc gtaaccataa tctccttttt cttcatcacg tactatgcga ccatcttcaa
    12061 tagcaacaac acgatgacga aatgtattca caatatgact gttgtgtgtc gccattaaga
    12121 tagttgttcc ctgaacatta atacgttcaa gtaactgcat aatttcccat gaaatctcag
    12181 gatctaaatt ccctgtcggt tcatctgcaa tcaataattt agggttgtta acaatcgcac
    12241 gcgcaatggc cacacgttgc tgctcccctc ctgatagctg acttggaaaa gaacgcatct
    12301 tatgtttcaa gccaactaaa tcgagtacct ctggcacgcg ttttttaatg tggcggcgct
    12361 tttcaccaat aacttccatg gcgtaagcta cattttcaaa gactgttttt cttggtagca
    12421 gtttgtaatc ttgaaaaact actccgatgt gacgacgaag aatcggaaca tcacgtgctt
    12481 ttagcttagt taaattgaat tcacccacat atagcttacc agttgtcagt tgttcttcac
    12541 ggtaaaggag tttgataaaa gttgatttac cagcacctga tgggcctacg agataaacaa
    12601 actcaccttg gttaacagaa acattgacgt ctctgagggc ggtcgttgag cggcggtatt
    12661 ttttagtaac accagacatt tctattagtg ccatgtttct cctttattat ttttagtctt
    12721 caatgcgcca cttaaggtag gcatcaataa agccattgat ttctccatcc ataaccttat
    12781 ctacctgagc aagctcaaag ttagtacgat gatccttcac catcgtataa ggggtgaaaa
    12841 cataagaacg aatctgactt ccccaagtga tttctttttt atcacccttg agagcatcta
    12901 cttcttgtgc tttcttttct tgttctaact gatatagctt agcctgcaac atcttcatag
    12961 cgcgatcgcg gtttccatat tgagtacggt caacggtaga cgataccaca attccagttg
    13021 gaatatgcgt caaacgaaca cctgttgata ctttattgac gttctgacca ccagctcctc
    13081 cggaacggaa agtatccatt ttaatgtcat catcacgtac ttctacttca atcgtatcat
    13141 ctaactctgg catcacttca actgaagcaa atgaagtatg acgacgttta gctgaatcaa
    13201 aaggtgatat acgaacgagg cgatgaactc ccatttctga tttcaacaaa ccgtaagcat
    13261 tggggccttc aaaagagagg gtaaccgatt taataccagc ttcatctcct gcttgataat
    13321 ccaatacttc tactttgaaa ccattagcat taccaaaacg ggtatacatt cgtaagagta
    13381 aatctcccca atcttgcgct tcagttcctc ctgaaccagg atggatttct aagatagcat
    13441 tattgtggtc atagggttca gataagagaa gcgtcatttc ataagcaccc attatcttat
    13501 ctagctgcat tagattttct tctaattctt ctttcaaaga atcatcttcg tcaagcatct
    13561 caagtaagag ttctgtttcg tcagataatt cttgcatatt atggaaagta tcatacttac
    13621 cttttaactc atttagttct tgagatgtct tttgcgctgc aatattgtca ttccaaaagt
    13681 ctggctcagt catgtgattt tcaagaagag caatctcctc ttccaaacga tctaagtcaa
    13741 agagacctcc tgaagctagt caacttctct ttattttcta ctattttttg gcgaatttca
    13801 gccacttcca tgagatttct ccaatctttg ttaatctgtt ttattttatc ataaggttct
    13861 taaaaatacc ataaaaggct taaacttgcc atttacgacg gattaattcc aactcttttc
    13921 ggctatcttc atcttttaag gttaaatgac tcataaacgc cagcatctca tcgtttggtt
    13981 ttttgacaat ttctcccaat gcccatatag ctgttgcagt atgaataggg ttattatttt
    14041 tatcaataat ctctattaat ttgaccactg cggttttatc atgagcattt gctagcgcaa
    14101 taatggcatt acgctgtaaa atatttttac ctcgccaact tccagcaatc ataccaaatt
    14161 tttctttaaa ttgtccattt gataaactca aaaatggtat taattctggt tgagccaact
    14221 caggatcaat ctctgtagct ggtgaattgt ttataccctt gttataagga cagcaaattt
    14281 ggcaaatatc acaaccatag ataactgttt taatcttttt tcgaaactct gtgtccatca
    14341 ttcccttatc ttgggtttga aatgatagac aacgcttggc attcattgag ccatcaccaa
    14401 ttaaacaaga agttggacag gcatctagac aacgacgaca gtcaccacaa tcataatcga
    14461 caggcttgtc tggctcgatc tctaaattgg taattaattc tcccaaaaac atataagagc
    14521 catattcttt agaaataact agaccatttt ttcctataaa accaataccc gctctttggg
    14581 caactgcagt atcaactaaa gctccagtat cgaccattgc tttttgttgc aaaggaaaat
    14641 ctcgacacag ctcttcaatg ccttttgata gtctgtctaa cttttcgccg accacataat
    14701 gataatcaag cccccacgaa ctaggtgtaa tttttccacg tttataaggt gttttttgag
    14761 gttgctgagg aagtttgtga ggataagcaa cgccaattga aataatcgtt ttagccgatt
    14821 ctaaaagact ttcaggggag atacgatcct ctatgacttt atgttcaaat cctgaattgc
    14881 gcccctcttc cacagaagca cgcaatgact tttccaaata atcaaagtta tctgccgtcg
    14941 taaaaccaat tttagagata ccaatttctt tggcgagcgc cttaatttct gccttaatag
    15001 tcatactact atcataatca aaataagtta agacttcaag gaaaaagaag gacaattcta
    15061 atcaaacata accattttac ttcctgattt atctgggttt tctctcttaa catgcacaag
    15121 aatgcaacaa gtaaattcaa ttacatcgta aaagtccctt ttctggttac ctctacttgg
    15181 tcagaaatca catctccatc acgtcttgtc tagacagtta gctcagctct aaagtaagtc
    15241 tgactataag caatggacct acgaagacaa gcagcataac acttccaaat attattatac
    15301 ctaaccaaaa ccgagtcaca ttacccgtgc aactcatgga ctcagatact gcctttgtca
    15361 aagcagtatt atgatccttc tatatttact cactagccaa tctaaaaaca aatccaaata
    15421 atgaccacgg ttaaacatat ctcctgccac atgaagatgg tcaacgacta atgatcacat
    15481 ccatatcaca aaaatcataa tccttttcta ggtgatctta tgcgacggtt ttttgataat
    15541 aatttaaaca tagtactctt ttcagtgtca tattgtaaat aggtagctaa aaaacagtaa
    15601 aaacacataa acgtattctt gttattggtc tgtagaaagt cctagacgta ttcttaagtg
    15661 tcttgaagta tcatgatcag ttagttgcgt tacttcacga tccaaaacaa ccgattttta
    15721 cacacagttg tcctaaatga tctatcttgt gatcagcttg actctgatca atgccatatc
    15781 ggtagtcggt aatggcaaaa actgtcagat tggctgcttt ggcggcagca atgccttttt
    15841 ggctgtcttc tactacaagc agttgttttt tttgtaatcc tagtttttgt actgctttat
    15901 tataaatatc tggataaggt ttgcctctag aaacatcttc acgcgctagg attatttcaa
    15961 aataatcttt tatttgcgtt gtctccaacg ccaacaaaac atcctgacgc ttcgagtttg
    16021 atgccacagc cagtttgata ccttgttttt tcaactgttc aagacaagag ttcacttctg
    16081 taatcaacag tttttgataa ggaggcttat gcgcttgttt gtaagcgtca tagtcagttg
    16141 taattgcctt aacgatagca tcatccctat ttttacctaa caactctttc cataattctt
    16201 ggagattgcc cccaataaaa tctttagagt tcaaatgatc aatgggaatt ccctttgtct
    16261 taaaaaaatc ttctcgtcgc ctcagataaa aaggttctgt atcaaataaa acaccgtcca
    16321 tatcaaaaat aattccttta atcatcaaca tttctccttt ttttctattt tagcataagt
    16381 tgctgtaaaa gctgtacagc tagtccattc taagtgatat cactttagat caggtcaata
    16441 ctaacgaatt caaaaggtat tacttttgtt tgatcataaa aagtttatat cctatatatc
    16501 aaatgacagg ctcatcttgt taaattagct gctcttatat ctatactatc tgaaaaaaca
    16561 taagcagaag catattaatt gaatgaatga taaaaaacgt ttttactagc actaaagcca
    16621 aggtaaaaac gttttttaga ttattgtcgc aaacttttga tataatgagc ggctttctta
    16681 gtgattaggt tatattgttt ttggctcgct aactgattaa actcgcctcc tatgcctaga
    16741 acatctactc cagcggctag ccagtctttg agattatctg aagaaacccc gcctgtaacc
    16801 ataacctcta cttgtggcaa aggagatttg attgcccgaa taaaggacat ccctacagta
    16861 gaaccaggaa aaattttgac catatcaacc cctgattcta atgctgtaac cacttcatta
    16921 accgtcatac aacctggtaa ataaggtatg ctataacgat gacaaatcaa agccactgct
    16981 cgattgaaat taggaccaac aataagctgt gctcctgcta aaatagcttg gcgggcagtg
    17041 acatcatcca aaactgtccc agcacctatc aatacctcag gatcttcttt gaagcgttca
    17101 gctaattgac cgataacctc actagcaaag gggttagtat aggtgacttc aattgtctta
    17161 atgccacctt caatactggc caggctgcaa gctaaagctt cctcactaga ctctcctcgt
    17221 acaaccagga caagccgatt agccttaagt ttggttaaga tttctatttt tcccatatca
    17281 tcacctctgg acatctcgtt gattagctaa gactgcttct acttgttggg cgctgtgata
    17341 gagctgatct tcagctactg tacattttag gctagctgtt gccacagcaa aatcaaggtt
    17401 gtactgcttt tcgtcacctt ctaacaactg ataaagtaaa cccgccacaa aagcatctcc
    17461 acttccaacc cgttgcaaga ctggggtcgt cacttcacag gattcgtaaa actgcccatc
    17521 ataggtataa gccttaaaat gattactgcc ttgggcatca tttgaacgct ccgtatggta
    17581 aatagcttgt aactgatagc gctgataaag tcctgccaga cgttctctaa tcatcgtagt
    17641 atctgcctta ttcctatcaa acatgtcaaa atcgtcactg tctaacagca aaggttccat
    17701 gccaaaaata atatccgcgt attgagcaaa atgagaaaag agtcgtttag catcagctac
    17761 cgcaatcata ctagatctaa agttaagatc aaaagaaaca caaatatccc ttttcttagc
    17821 ttctctcaca agtatctcaa tcagatcctg agtttttttg cccagcgcca aactgatccc
    17881 actaaaatga aagtgactaa tgccttcaaa aatggcagct agatcaagac tatccttatc
    17941 taaggccgaa aagctagagc cacagcggtc ataataaacc tgactagaac gacaaccaaa
    18001 gccattttca aggtaataca gcccaacacg gttgccctgc caagccgtca gggtcatatc
    18061 cacaccgctt tgcttcaaaa actgatgaaa agcgtgacca acaggattat ctggtagggc
    18121 cgtaaatagc cttgcttcta agccaaaacc gcctagagtt cttgcaatat taacttctga
    18181 accgccgaaa aaaagctgag cgtcgcaggc attggtcaaa ggctgaaact gattgggact
    18241 aacgcgtatc agcggttcac caaccaataa taacttagac atgtgatctc ctttcctcgt
    18301 caaaatggaa ttactgttca agtactgatt tcaaataagt aactaattct gacggctccg
    18361 cattggcaaa gaagtactct ttaaaatgag cgccagaaat cgtttctttg aggaaatctt
    18421 ggtcgatgtc tttgacaatt gccaacaaat ctctgtaagt aatttttttc agatcactta
    18481 aaatacgtgc attccgctgt tcaggaatag ctcgctcttt agggtaacca ccacccattg
    18541 gttctgcaaa gaggcgttca aatattaagg tcaaattcaa ctctgctccc caaccaaaac
    18601 ctttggcaaa aggaatggac aaggcattac caccattgat ttgagaaaag agataagctt
    18661 ctgttggctc actcgcaaaa ccacaggtaa cccctgggaa gctgttcaag gccaacatag
    18721 ctccaacacc tgttccacaa ccagtcacca caaaatcggc cgccttagtg gtcaataaaa
    18781 tagaagctaa gagtccattt tgaacatagg tcaactggct ttcaccttct gtgccataca
    18841 tgccatagtt aaagacttga tagccgtgtt tatctgtcac tgaggtaagg gcatcgtaaa
    18901 taataccatt tttagccgct tggctatttt cattaattaa tgcaattttc atataaaatc
    18961 tctttctagt gtgtgattaa ggttgttttc caatataagc taaaatgcca ccgtcgacat
    19021 aaaggatatg gccgttcaca aaattactgg catcgctagc tagaaaaacg gctggaccag
    19081 ctaagtcttc tgttgtcccc caacgtgctg ctggtgtttt agcaatgata aattgatcaa
    19141 aaggatggcg actaccatct gcttgtcgct ctctcaacgg agctgtttgg ggtgtcgcaa
    19201 tgtagccagg accaatccca ttacattgaa tgttggcttc tccaaactca gaggctatat
    19261 ttttggttaa cattttcaag ccacctttag ccgccgcgta ggcactaact gtttcacgcc
    19321 ccaattcgct catcatagaa cagatattta taattttacc atgtcccttt gcaatcattg
    19381 atggtaatac agcttttgac acaataaaag gagcatttaa atcaatatca ataacttgac
    19441 gaaaatcttc tgcggccatt tcaagcatcg gcgtacgcct aataatacct gcattgttga
    19501 ccagaatatc aataacacct acttcatctt caatttgact aaccatctgt tggataccaa
    19561 cttcatcagt cacgtcacaa acatagccat gcgcttctat ccctaactct cgataggcag
    19621 ccaacccctt atcaactaac tcttgtttga tgtcattaaa cacaatagtt gcacccgctt
    19681 gagcataggc tttggcaatt tcaaaaccaa taccgtaaga tgctccggta atcaaggcaa
    19741 tcttaccttg taacgaaaac atattttcca taggattctc ctttttgtta ttaaattaag
    19801 taaacctgtt taccaagact ataacaaagt aaactaattt tgtcaagatg tttatgaaaa
    19861 cggttcaaaa tttaaaagag tgctcttatc caaactgtca ttcttgttta gtcttctcct
    19921 atacttaata gctattaaga cttttctaca ttaaatagtg acaaaaaaga ccatttttga
    19981 ttctttttta gcacaaccgt tcactttttc tttttcaaaa atctttttaa aaaagtattg
    20041 acaaagaatt ttgaaagcgc tacaatattt ttgagtaaac cggtaaacca aaggagattt
    20101 atttatgatt gctattatcg ttatgggaca tggacatttt gcgagtggta ttgtttcagc
    20161 cttagaattg atcgcaggca aacaagaaaa ggtcactgct attgatttta ctgctgagat
    20221 gaccgccgct gatgtgcagg accaattatc tcgtgcttta atcccagaag aggaaacctt
    20281 agttctttgt gaccttctag gaggtacccc ttttaaagtc gctgcaacct taatggaatc
    20341 tcttccaaac acgacgtgta atgttctttc tggccttaac ttagccatgc tgattgaagc
    20401 tagttttgca agacaaacag cagcttcttt tgacgactta gtatcaggac ttataatatg
    20461 ttctaaagaa ggcattgttg actggaaaac tctttctcag caagaagacg gtgcgacaga
    20521 cgatgagtta ggaggcattt aatgacacga cttttaaaaa ccattgctct tgaacctatc
    20581 aagcagcctg aacgatttac caaagaagat ttcctaagcc aagaagacat tactcaggcc
    20641 cttgacttag ccctcaaaca agttcggctt aacatggact acttcaaaga agattttcca
    20701 acgccagcta ccaaagataa ccaatacgcc attatggaca acacggaatg gaccaatgcc
    20761 ttttggactg gctgcctctg gttagcttac gaatacagtg gagatgatgc cattaaagct
    20821 ctggctcaag caaatgacct ttctttccta gatcgagtaa caagagacat tgagctagat
    20881 caccatgatt tgggctttct ttacacccct tcttgcatgg ctgagtggaa acttttaaaa
    20941 acacctgagg ctagagaagc ggctttgaaa gcggccgaca aattagtcca acgctatcaa
    21001 gacaaaggcg gctttattca ggcctggggg gagctgggta aaaaacaaga ttaccgttta
    21061 atcattgatt gtctcctaaa catccaatta ctcttttttg ctagccaaga aactggagac
    21121 aaccgttacc ctgacatggc gatcaatcat ttctacgcct cagccaatca tgtcatccga
    21181 gatgacgcct ctgcttacca caccttctac tttgatccag aaacaggcga tcctgttaaa
    21241 ggggtcaccc gacaaggtta tagcgatgat tctgcttggg ccagaggcca agcttggggc
    21301 atttatggta ttcctttaac ctatcgtttc ctaaaagaac ctgaacttat tcaactcttc
    21361 aagggcatga cccattattt cttgaaccgt cttcctaaag accaggtttc ctactgggat
    21421 ttaatttttg gagatggtag cgagcagtct cgtgatagtt cagcaacagc cattgctgtg
    21481 tgtggtattc atgaaatgtt aaaaacctta ccagatcatg atcctgataa aaaaacatat
    21541 gaagctgcca tgcacagcat gctaagagcc ttgattaagg attatgctaa caaagatctc
    21601 aatcctggtg ctcctctact gcttcacgga gtctattctt ggcactctgg aaaaggggtg
    21661 gatgaaggaa atatctgggg agactattac taccttgaag ctctgcttcg tttctacaaa
    21721 gactggaacc cttactggta acaaacaccg ataatcacat ttaaaaagga gattttatga
    21781 cacaaccaaa cattatcatg acgcgagttg atgagcgctt gattcacgga caggggcaat
    21841 tatgggtcaa atacctcaac tgcaacactg ttatcgtcgc taacgatgcg gtttctgaag
    21901 ataagattca acaatccctc atgaaaacag ttatcccatc cagtattgcc attcgttttt
    21961 tctccattca aaaagtgatt gacatcattc ataaagcaag tcctgctcaa agtatcttca
    22021 tcgtggtcaa agatttgcaa gatgccaaac gcctagttga agggggtgtt cccatcacag
    22081 aaatcaatat cggtaatatt cataaaactg atgataaggt tgcgattacc cagtttattt
    22141 cgctgggaga aacagacaag tctgctattc gttgcttagc ccatgaccac caagtggttt
    22201 ttaacaccaa aacaactcca gctggcaata gcgcctctga cgttgacatc ttagattata
    22261 tttaatgaat aaaggagatt gatatggata tcaatttgtt acaggcactt ttaattggtc
    22321 tttggacagc cttttgtttt agcggaatgt tacttggcat ctacaccaac cgttgtatta
    22381 ttctgtcttt tggtgtaggg atgatcttag gtgacttgcc aactgcactt agcatgggag
    22441 ctatctccga attagcttat atgggatttg gagtgggtgc cggtggtacc gttcctccta
    22501 atcctatcgg ccctggtatc tttggtacct tgatggctat taccagtgct ggtaaagtca
    22561 ccccagaagc ggccctagcc ttatcaacac caatcgcagt tgccatccaa tttcttcaga
    22621 cattcgccta taccgctttt gctggggctc ctgaaaccgc taaaaagcaa ttgcaaaaag
    22681 gcaatataag aggcttcaaa ttcgctgcca acggcactat ctgggctttc gcttttatcg
    22741 gattaggcct tggtttatta ggtgccttgt caatggatac tctccttcac ttggttgatt
    22801 atatcccacc tgtcttgctc aatggattga ctgttgctgg taaaatgtta cctgctatcg
    22861 gatttgccat gatcttatca gttatggcca agaaggagtt gattcctttt gtactaattg
    22921 gttatgtttg tgcagcctac ctccaaattc caaccattgg tatcgctatt attggtatca
    22981 ttttcgcctt gaatgaattt tacaacaaac ctaaacaagt cgatgcaaca actgtccaag
    23041 gaggccaaca agatgactgg atctaataaa ttaaccaaga aagattacct caaaacagct
    23101 ctgagagctt tcttcctaca aaatgggttt aattacagta attaccaagg tatcggatac
    23161 gccaatgtca tctatcctgc cttgaaaaaa cattttggca gtgataaaaa gggcttatat
    23221 caagctttag aagataactg tgagttttac aatactaacc ctcacttcct tcctttcatc
    23281 accagtctgc acttggtcat gttagaaaat gatcgtcctg aagaagaaac ccgaaacatc
    23341 aaaatggcac ttatggggcc tttagctggt atcggtgact ccttatcaca attttgcttg
    23401 gcaccactct tttcaacgat tgcagcttcc ttagccagtg atggtttagt tttaggtcca
    23461 attttcttct tcctagccat gaatattatc ctaactgcta ttaaaatcgg ttctggtctc
    23521 tatggctata aagtcggcac aagctttatt gataaattaa gtgaacaaat ggcggttgtg
    23581 tcgcgcatgg caaatattgt cggtgttacc gttatcgctg gattagctgc tacttctgtt
    23641 aaaataactg ttcccattac ttttgcggct ggcaaggtgg atgcggccaa tacagcacaa
    23701 aaatttgtga ctattcaagg aatgcttgat aaaattgctc ctgcactttt accagctctc
    23761 tttaccttac tcatgtatta ccttattaaa aacaaaaaat ggacaaccta caaattggtt
    23821 ctcctcactg ttcttatcgg tattatcggt agctggttag gtattttagc ttaatggttc
    23881 acagagacct gttatgagca tagggaaata gttcctaagc acatgatgag gtctcttttc
    23941 ttttggaaag gaaatgtcct atgtctcttg ccttcacacg ctttaaagaa acagtcaatc
    24001 cagacttttg caggaattac ctgctagact atcagactga cagctatgct gatcaaaaaa
    24061 gaatagctga cctactctta accaatacct ttttatttga agataattgg gatatggagc
    24121 cctgccacat cccttaccac ttagatccca ttacttggca agaggctgtc acagatgatc
    24181 ctgagtggaa ttttatgtta aatcgacaga cctatctcca aaaattaatc ctcgtctacc
    24241 ttgttgaaag agatgaacgg tatctcctaa aagccaaaag tttcatcctc aattggattg
    24301 aatcagctat tcctttagac cctaaggggt tagctactag aaccttagat actggcatcc
    24361 gttgttttgc ttgggtcaaa tgtttgattt accttaatct ttttaacgcc ttaaccaagc
    24421 aagaggaaag cctcatccta gcttccctgg aaaaacaact tcaatttctc catgccaact
    24481 accttgataa atacagcctc agcaattggg gaatcttgca aaccactgcg attttattag
    24541 ctgatgccta ctatggttct gaccttgata ttgctgcagc aacagctttt gctagaaaag
    24601 aattgacgca acaaatcgca ctccaaattc tcgaagacgg cagtcaattt gaacaatcaa
    24661 ccatgtatca tgtggaagta ctcaaagccc ttctggaatt aactgctcta gtccctgatt
    24721 atcttccaca gcttagacct actttgcttg ccatgagtga ttatctcctc aaaatgactg
    24781 gccctgacca caaacagatc cccttaggag acagtgactt taccgatacc agagatattc
    24841 taacactagc agccactatc cttgaagaac cacacttaaa agctgctgct tttcccacac
    24901 ttgatatcga tagtcttctc cttctaggag aaaaaggtgt ccacactttt gaacagttac
    24961 ccgtccaaac cttaccaact tttgcgcatc actttgaaca ttccgggcac attaccatca
    25021 atcaagaaaa ttattatctt tttttcaaaa atgggcccat cggtagttcc catacccata
    25081 gcgaccaaaa tagtctctgt ctctattata aaggacaacc acttttctgt gatgccgggc
    25141 gatacactta caaagaagaa ccattacgct atgccctaaa aagcgctagc catcattcta
    25201 ccgccttctt aaaagaacaa ttacctgagc agattgatag ctcctgggct tacctttctt
    25261 accccaaatc caattattgt caccttcgac aaaatggaca cgtttacttt attgaaggta
    25321 gctaccagac gcaattctct gataggaaca actaccaaca tgaccgacaa attctcatct
    25381 taccaccagg aatgtttctt atcattgata cgatacaggc tcaaggtaac cactgtcttg
    25441 tcagtcaatt tattcttgat aatcacttag acgtaaagac agatcacctt agtgacctca
    25501 gactaatcag tgactgccct ttcactatcg aagaaacgat tttgtcaaaa aaatacaacc
    25561 aatacctgac tagtcacaaa ttcatcaaac gaaaaccctt taaagacaag ggttgcacca
    25621 gtaccctgtt agtccctgac gataccaaag ttactccctt aacaccactt caaacaggca
    25681 aacgcaaccc aattgagacc gccctttcct ggcatttaaa aggaaagcag tttgactaca
    25741 gtatctgcgt tctccaagag gacttaatta aaggagaaaa actagttctc ctaaatggtc
    25801 ataaaatcag aggaaaggtg gttgttatca accatatcac gaatgagatt attcgattga
    25861 aacactaaat cttttacgag tccttatgtt ataatatgac taaccattac tatttttaag
    25921 gagtgtatgc aatgcagcgc aaagtaacca tcaaagatat tgctgaatta gcgaaaactt
    25981 caaaaacaac agtttctttc tacttaaatg gtaggtttga caagatgtct gaagaaacta
    26041 aaaaccgcat taaaagcacg attgaagcta ccaattataa accaagcatt gctgccagaa
    26101 gtctaaacgc caaatctact aaactcattg gcgtggttat tggtgatatt accaatagtt
    26161 tttccaatca aattgttaag ggaattgaaa gcaaagccca ggaatttggt taccaaatta
    26221 tcatcggaaa cagcaactac gacccttctc gcgaagatga actcattgaa aagatgctga
    26281 acctcggagt tgatggcttt atcattcagc ctacctctaa tttcaggaag tattctcgca
    26341 ttatcgatat taaaaaaaag aaggttgtct tttttgatag tcaactttat gagcatcgta
    26401 ccaactgggt caaaactaat aattatgatg ctgtttatga taccattcaa caatgtatcg
    26461 ataaaggtta tgaacatttt atcatgatca cgggtaaccc caatttactt agtactcgta
    26521 ttgaacgcgc ttcgggcttc attgatgtgt tagaagctaa tcatcttact catcaagaaa
    26581 tgattattga tgaaaatcag acttcttcag aggcaattgc tcaatttttg caaggatcac
    26641 tgactaaaaa gagtttggtt tttgtcccca attgttgggc tcttccaaaa gtatttacag
    26701 ctatgaagtc tcttaaattt aatataccag agattggact agtaggattt gataacattg
    26761 agtggacaaa attttcttca ccaacactaa caactattat ccaacccgcc tatgaagaag
    26821 gcgaacaggc tactaagatt ttaatcgatg atattgaagg tcacagtcaa gaagccaaac
    26881 aacaaatttt tgactgtcaa gtcaattggc aagaatcaac tttttaatgt caggcatacc
    26941 aatagtcctt atcgttgtaa cgattataaa aaaaggtttg agacaattgt ctcaaacctt
    27001 ttagcgtcta ttaaattgct ttttcatctt gaccaagtga tcgttgaaca gctttgacaa
    27061 gctcaacaag aacaaccatc aagagacttc cgataataac cactaaccat tgtgtgatcg
    27121 tcaagtgtgt cacatggaag aattgattaa atccaggaac aacaactgtt gccatcaatg
    27181 ctacaaaggc cactggaata gaatagttga acaatttgtt tttgaacaac ccaacagtaa
    27241 agatggattg gtaaacagat ttcacgttgt aggcatgtac caactgaatc aaaccgaggg
    27301 tcacataagc catggtcaaa gcatctgcat ggacatcatg atagcttgtg tgttctggga
    27361 acatcaaggc aaaaccataa accccaagaa ccaaaatggt ttggaaggca ccttggtaaa
    27421 gaatggcttc cttcacccca ccatcaaaga agcttgactt acgtccacga ggtttgtgct
    27481 tcatcacacc aggctcagca ggttcaacac caagagcaat agctggtagg gtatcagtta
    27541 ccaagttaat ccaaagcaag tgaactggtt gaagcacatc ccaaccaaac aaggttgcaa
    27601 ggaagatagt aaagacttct gccatgttag cagaaagtaa atattgaatt gttttttgaa
    27661 tatttgagaa gaccttacgt ccttcttcaa ccgcaacgat aatggttgca aagttatcat
    27721 cggcaagaac catgtcagaa gctcccttag aaacctctgt acctgtaatt cccataccaa
    27781 taccaatatc tgccgtttta agagatggtg catcgttaac cccatcacca gtcatggcaa
    27841 caactttgcc ttcattttgc caagccttaa cgatacgaac tttatgctca ggagatacac
    27901 gggcatacac ggagtattgt ttaaagactt tttggaactc ttcatctgat aattcgttga
    27961 gttcagcacc tgtaaagaca tgatcaacgc catcttcttc gataatacca agacgtttcg
    28021 caatagcttt tgctgtatct tggtggtcac cagtaatcat gattggacga atgccagctt
    28081 ccttagctac tttaacagcc tgtgctgctt caggacgttc agggtcaatc atccctacca
    28141 aaccagagaa gacaagatta gcctcaacaa tttctgtttc cagtgttgga agagcatcag
    28201 aatatttgta agccatcatc aagacacgaa gagcttgttt ggcaagactc ttattggtat
    28261 caagaatggt ttttttatca gcatccgtaa taggacgaat ttgtccattt tcttcaatct
    28321 gtgtgacacg tttcaataac tgatctggtg cacctttaac agcgatgaaa tatttgccat
    28381 cagcttgttt atgaatggtt gacatcaact tacggtcaga atcaaatggt agttctgcca
    28441 cacgaggttc tgccaccata gcctcacgta cgtcaaaatt gtggtctaac ccaaactgta
    28501 ccaaagctgt ttctgttggg tcaccaatta acttccctga aggatcaact ttagtatcat
    28561 tagcaaagtt catcacacga agtgtcgtat tgtcaaaggc aatatcagct gatgaacttt
    28621 ggagtgtccc gttggtataa actttttcaa cggtcatttg attcattgtc aaggtacccg
    28681 ttttatcaga agcaatgatt tcagttgatc ctagcgtttc aacagctggt aatttacgga
    28741 taatggcgtt acgtttagca agtacttgag ttccaagaga aagcacaaca gtaacaatcg
    28801 caggaagtcc ctctggaata gctgcaacgg caagcgctac tgaagtcatc aagccttcaa
    28861 gcgggtgttg accacgcaag aagactccaa cagcaaaagt caccgctgca atcacaagga
    28921 tcgcataagt caaaatctta gaaaggttgt caaggttttg cttcaatggt gtatctgtct
    28981 catcagcatt agcaagcata ccagcaatat gcccaacctc ggtgtacatg ccagtgttag
    29041 tgataacccc aatcccacga ccatatgtca catttgagtt ttgatatccc atattgacgc
    29101 gatcaccaat accggcatct tctgaaacag ccgttgacaa gtctttttca accggtacag
    29161 attctccagt aagcgctgct tcttcgattt ttaaggagtt agcttccaaa agacgtagat
    29221 cagcagggac aacatctccc gcttctagca agacaatatc tccagggacc aattctttag
    29281 agtctatctc agtcacatgc ccatcacggc gaatacgagc cagtggactt gacattgatt
    29341 tcaaggcttc aatagcagct tcagcttgtc cttcttggta aacaccaaaa gcagcattta
    29401 ggataacaac agccaagata ataatggcgt ctgtcaaacc ttccatcccc tctgtaagaa
    29461 ctgaaagaag ggctgccaca atcaaaataa taatcatcaa atccttaaat tgatcaagga
    29521 atttcataaa taaacttcgt ttttcgcctt catcaagctc attacgacca tactctgcta
    29581 agcgctcttt tgcttgggca gacgtaagac cttcgcgact ggtctctaat tgagccagta
    29641 cggtctcttc actttgcgtg taaaacgctt catgtctttg ttctttagac aaattagtac
    29701 ctccttggtc tttttatttt agttattcaa ataaaaagac ctgtttattt ttcttaaaca
    29761 agtctcgctg tttaagattg taccggaaac cgaaattccg tattgacgat acaatcacgg
    29821 ctagccgtct gctactccct tgatataata accattatag taaaaacctg actaaaaaac
    29881 aagaataatc cctaatcaga tgatttactg ctatcttttt agttaatccc aactcagctc
    29941 aagatgatag cttgcaaata gcatttctgt ttgagcttga agcaaatgat aatgaaggtc
    30001 caatttttga caagaacaat ctaagtggta atgactggta tctgtcaaaa attgttgaac
    30061 ccccatcggc gtaggtagag caatcaggac cttcttgccc gcaaaaaatt tcatgattga
    30121 ctgagggttg gaaaaacggc tcatggtcag ttctgtctca ttgtacttga tgacaacctt
    30181 ttccttgtca gtgttttgat agatgaggta ctgatagtcc cctttttctc gccactcaca
    30241 atcatgaatt tcttgaataa tctctgtctc atctccaaag cgaatatggt tggttaactg
    30301 taatttcata actcttcttt ctattctaac tattctaagc tcgtctgttt attctatcaa
    30361 tttctcctta ttttatcaat ttttgatata ataaaaatta tgaatgaaaa agtatttcgt
    30421 gaccctgttc acaactatat ccacattgat aatccattaa tttatgacct tatcaatacc
    30481 aaagaattcc aacgcttacg acgcatcaaa caagtcccta caacagcttt caccttccac
    30541 ggcgcagaac atagccgttt ttctcactgc ctaggtgttt acgaaattgc ccgtcgggtg
    30601 acagctattt ttgaagagaa atacgctgat atctggaata aagatgaaag tctggtcact
    30661 atgacggctg ccctcttaca tgacattggt catggagcct attctcatac ctttgaggct
    30721 ctttttcata cggatcacga ggcctttact caggagataa ttaccaatcc tgagacagaa
    30781 atcaatgcca ttttggtgcg tcatgctcct gattttccag acaaagttgc cagcgtgatt
    30841 aatcatacct atcctaacaa gcaagttgtg caactgattt ccagccagat tgactgcgac
    30901 cgtatggatt accttttaag agattcttat ttttctgctg ccaattatgg tcagtttgat
    30961 ttaatgcgca tcctacgtgt gattcgacct gttgaagatg gcattgtctt tgaacatagt
    31021 ggtatgcatg ctgtcgagga ctatattgtc agtcgttttc aaatgtacat gcaggtctat
    31081 tttcatcccg ccagccgtgc tgttgagctc atcttacaaa atcttctcaa aagagcccaa
    31141 cacttatatc ctgagcaaca ggcttatttc caaaaaacag ctcctggact catccccttc
    31201 tttgaaaaga aggctaattt agcagattat atagccctag atgacggagt catgaatact
    31261 tacttccaag tctggatgac aagcgaagac catatcttat cagatttggc cagtcgcttt
    31321 attaatcgaa aaattctgaa gtctgttacc tttgaccaag attcccgagg agagttagaa
    31381 cgcttgcgcc aattggtcga atcagttggc tttgatccag attattacac cggtatccat
    31441 atcaacttcg acctgcctta tgatatttat cgaccagagc tcgaaaatcc aagaactcag
    31501 attgaaatga tgcaaaaaga cgggagcctt gctgaattat ctcagttatc tcctattgtc
    31561 aaagcattaa cagggacaac ctacggagac cgtcgctttt attttccaaa ggaaatgtta
    31621 gagctcgatg acctctttgc tcctagcaag gaaactttta tgagttatat ttccaatggg
    31681 cattttcact ttagtcagta aagcccttta agattgcaga aaaagtcttt tttgatactt
    31741 ttcttaggtg gtgcttatgg cagtgacttc ctttggaatt ctatgcttta tttttgagcc
    31801 tagggtctca aaaatcccgc gtaacgtcac tgccagtatt gacaccactt ttgccacagc
    31861 aaaaagcagc tgttttggct cacgtcacac gcagaaatga gaaattagtt gtcaaatcag
    31921 cagagcagtt catgcttttt gagcatcaaa ctgggtttgt ctccattcta agattgaaga
    31981 aagagtactt tcttcaatct ttttagttac tacagaggcg attgagctaa actaaaacgt
    32041 tttctctcgt ttttccttaa gtttcctttc ccatcccatg acaaaagcac cgatttttag
    32101 taagatagga gggagaacat ttttaagata aaccacaaaa aacaaggagg atgccatgtc
    32161 tatcaaactg gttgctgtcg atattgatgg cacattactc actgatgacc gtcgaattac
    32221 agatgatgtt tttcaagctg tccaagaggc taaagcccaa ggtgttcatg tggtgattgc
    32281 tactggccga cctattgccg gagtgatttc attactcgaa caattagaac tcaaccacaa
    32341 aggaaaccac gttatcactt ttaatggtgg cttggtgcaa gatgccgaga ccggcgaaga
    32401 aattgttaaa gaattgatga cttacgacga ttatctggaa acggaattta tgagccgaaa
    32461 attaggagtt cacatgcatg ccattaccaa agaaggtatt tacactgcca atcggaatat
    32521 tggaaaatac acagttcatg aatcgacttt ggtaaacatg cctattttct atcgcactcc
    32581 cgaagaaatg accaataaag aaatcatcaa aatgatgatg attgatgaac ctgacctttt
    32641 ggacgcggcc atcaagcaaa ttcctcaaca tttctttgat aagtacacca tcgtcaagtc
    32701 aacccctttt tatttagagt tcatgccaaa aaccgtcagc aagggcaatg ccatcaaaca
    32761 cttagctaaa aaactcgggc tagatatgtc acaaaccatg gccatcgggg atgctgaaaa
    32821 tgatcgtgct atgttagaag tcgttgccaa ccctgttgtc atggaaaatg gggttcctga
    32881 attgaaaaaa atagccaaat acatcaccaa atccaacaat gacagtggtg tggcacatgc
    32941 tattcgcaag tgggtattaa actaatgtat acatataaaa tcggaatatc tcctgaagaa
    33001 catgatcagt ttgtcttagc acagccacaa gctggcttac ttcaaagttc aaagtgggga
    33061 aaagtcaaag ataactggaa acacgaacgc atcagctttt atgaaaatgg ggtacaagtt
    33121 gctgctgctg cttgtttaat cagaaaactt cctcttggtt tcactatgat ttatatccca
    33181 cgtgggccaa tcatggacta cgccaatttt gaactccttg atttcgttat taaaacgctc
    33241 aaaactttcg gaaaaagcaa acgagcgctt tttgtcaaaa ttgatccaag tttagtcatc
    33301 aaacaaactt tagaaggaaa agaaagcaaa gaaaatgatg tggccctctc tattattgct
    33361 tttctaaaaa aactcggtgt cgaatggtct ggcagaacaa aagaactcga agacactatt
    33421 caaccaagaa tacaagccaa catctacgcc aaggattttg actttgacag cctgcccaaa
    33481 aaagccaagc aatccattcg taccgctacc aataaaggtg ttaatgtcac gattggtggc
    33541 agtgaattgc tagacgactt ttcagccttg atgaaaaaaa ccgagaatcg aaaaggcatt
    33601 atccttcgag gcaaatccta ttatcaaaaa ttactagata tttatgctgg tcagtcctac
    33661 attactatgg ctagtttaga cttacctgaa caaaaaaaaa ccttgatcca acagttggac
    33721 aaagccttag cagaacaagt acgattaaca gataagagta aacctagcaa agtagcagaa
    33781 aatcaaaaaa ccattgcacg gctacaaaaa gatttaacca ttttaagcga gcagctcgct
    33841 gcaggcaaaa cccgcatccc actagccgcc accctaacct tgatttatgg cgagacttct
    33901 gaaaatcttt atgcgggaat ggacgatgat tatcgcaatt atcaagctcc tcttttaacc
    33961 tggtatgaaa cggctaaaga agcttttaaa agaggctgcc gctggcataa tttaggaggc
    34021 gtggaaaatc aacaagatgg tggactctat catttcaaag ctagactcaa ccccaccatc
    34081 gaagaatttg caggtgaatt caacattcct gtcggccttg tttcaagctt agccatcttg
    34141 acctataact taagaaaaaa attaaggagc acaactaatg gcactaattg aaatttcaca
    34201 agaacaattt gaccattact gccacagtct cgtccatcat tcctttatcc aaacctcaga
    34261 aatggccagc ttgatggcta aaagaggggc aaaaccacaa tttcttggac ttgaaaaaga
    34321 tggtgaacta aaggttgctg ctatggtctt tagccaaaaa gtggctggag gttggcgtat
    34381 ggaactcaat gcaggcccta ataccaatca tcccgaagaa ttagaacatt tttacactca
    34441 acttaaagac tatgccaaac aaaaagacgt tatcgaactc attctaaaac cttacgacaa
    34501 ttatcagtca tttgatactg atggcatccc tatttctcat ccaaacactg accttattag
    34561 ccttttaacg gcgttaggat ataaacatga cggtttaaaa acaggctatc ctgagggtga
    34621 acctgtttgg cattacgtta aaaagttaga aggaattgat tcctcacatt taacccattc
    34681 cttcagcaaa aaaggaaaag ctttaataaa aaaagctaat acttttggta ttaaattacg
    34741 tcaactgaaa cgagatgagt tacaccattt caaagaaatc actgaagcaa cctctgatcg
    34801 tagagattac cttgacaaat cattatctta ctatcaggac ttttatgata gttttggaga
    34861 ctcttgtgaa tttatggttg cgactcttaa ttttgaagat taccttaata accttaaaca
    34921 aagacaacta caactagcaa ccagcatcaa caaagttaaa ggagaccttg gcaaaaatcc
    34981 tcattctgaa aaaaagcaaa atagattaaa agaactatcc agccaattcg aaacctttca
    35041 ggtaagaatt tctgaagctc tccattttct tgaagagtac ggaactaaag atgtgttcct
    35101 tgcgggaagt ctttttatct ataccgaaca agaggccgtc tacctctttt caggatctta
    35161 ccccaaattt aataaatttt atagcccagc tctattacaa gagcatgcta tgctcaaggc
    35221 aattcacaag gggatcaaac aatataattt tcttggtatt actggaaagt ttgatggttc
    35281 agacggtgtc ttgcgcttta aacagaattt caatggcttt attttgcaaa aaccagggac
    35341 atttaaatgt tatccatttc caatcaaata tcatttcatt agattggcaa aaaagctatt
    35401 aaaccgctat taggctaatg catttgcctg tagaatcacc tttattctct catagtaaga
    35461 gttaagtcat ctaaaaaaga aaaggattta accttttctt ttttagatga cttagttaag
    35521 gaaatcaagc aaagcaagga agctatcagc ttcaagtgat gcaccaccta caagggcacc
    35581 gtcaacatct ggacaagcca tgtaatcttt aacgttttca ggttttacag aaccaccgta
    35641 ttgaacgcga actttatcag caacttcttg cccaaagtct gctgctacca cgtcacgaac
    35701 agctttacac atgttttgag catcatcttg agtagctgat ttaccagtac caatagccca
    35761 gattggctca taagctaaaa caagtgaagc tacttgctct gctgaaagac ctgcaagtgc
    35821 tgctgaaact tgcgcaccta caaactcaac ggctttacca gcttcataag tttcaagaga
    35881 ctcaccacaa caaacaattg gagttaaacc gttagcaaag attgctttgg cttttttatt
    35941 aatgtcttca tctgtttcat ggaagtaatc acggcgttct gagtgaccaa tcacaacata
    36001 gtcagctccc atttcagcaa gcacttttgg tgatgtttca ccagtgaatg cccctgtgtt
    36061 ttcaaagtag cagttttgtg cagcaacttt aagaactgaa tctttagcag cttcaatagt
    36121 ggttaccaaa tcaacagctg gggctgctac ggcaacatca acaaggtcag ttgaaggtaa
    36181 tttgcttgct acagcctcaa cgaatgcttt tgcttcttga gggtttttgt tcattttcca
    36241 gttaccagca ataattggtt tacgtaacat atcacatacc tcttcttttt ttatttatat
    36301 cttctatttt agcacaaatg accgacg
//
LOCUS       DAUDWO010000019        35819 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.019, whole genome shotgun sequence.
ACCESSION   DAUDWO010000019 DAUDWO010000000
VERSION     DAUDWO010000019.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 35819)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 35819)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..35819
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.019"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            237..908
                     /locus_tag="VHC05_000897"
     CDS             237..908
                     /locus_tag="VHC05_000897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="HEQ5402220.1"
                     /translation="MTRLLKRYPITIFLLGLTGLIFIAMQVVYGHLATGAQAIYQVGG
                     MFGLLVKAMPDQLWRLVTPIFIHIGFGHFFVNGLTLYFVGQIVEDLWGSRRFLLLYVL
                     SGVMGNAFTFWLTPETVAAGASTSLFGLFAAIVVLSFLGKNQALKDLGKSYQTLIVVN
                     LLMNLFMPNVSMAGHIGGVVGGALLSIVFPTKMRVITVKKTKRMLALVSYGIILVGVL
                     VLGFL"
     gene            complement(1008..1907)
                     /gene="galU"
                     /locus_tag="VHC05_000898"
     CDS             complement(1008..1907)
                     /gene="galU"
                     /locus_tag="VHC05_000898"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HEQ5402221.1"
                     /translation="MTKVRKAIIPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVEE
                     ALKSGIEEILIVTGKSKRSIEDHFDSNFELEYNLQAKGKIELLKLVDETTSINLHFIR
                     QSHPRGLGDAVLQAKTFVGNEPFVVMLGDDLMDITNPNVKPLTKQLIDDYEETHAATI
                     AVMRVPHEDVSNYGIIAPQAKAVKGLYSVDTFVEKPQPQDAPSDLAIIGRYLLTPEIF
                     SILEKQEPGAGNEVQLTDAIDTLNKTQRVFAREFKGKRYDVGDKFGFMKTSLDYALKH
                     PQVKDDLKAYIIQLGKALEKTKP"
     gene            complement(1940..2956)
                     /locus_tag="VHC05_000899"
     CDS             complement(1940..2956)
                     /locus_tag="VHC05_000899"
                     /EC_number="1.1.1.94"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="HEQ5402222.1"
                     /translation="MTKQKVAILGPGSWGTALSQVLNDNGHDVRLWGNIPDQIEEINT
                     KHTNRHYFKDIVLDKNITATLDLGQALSDVDAVLFVVPTKVTRLVARQVAAILDHKVV
                     VMHASKGLEPETHERLSTILEEEIPAHFRSEVVVVSGPSHAEETIVRDITLITAASKD
                     IEAAKYVQSLFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGYGDNAKAAVI
                     TRGLAEITRLGVKLGADPLTYSGLSGVGDLIVTGTSVHSRNWRAGAALGRGEKLEDIE
                     RNMGMVIEGIATTKVAYEIAQDLGVYMPITTAIYKSIYEGADIKESILGMMSNEFRSE
                     NEWH"
     gene            3254..3703
                     /locus_tag="VHC05_000900"
     CDS             3254..3703
                     /locus_tag="VHC05_000900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEQ5402223.1"
                     /translation="MSQVIGDLRELIHQIEQISDEIAKKYDVEHLAGPQGYVLVFLAK
                     HQNQEIFVKDIEKQLRISKSVASHLVKRMVKNGFINVMPSQVDKRYKQVVLAQVGRDK
                     LPLLRECRKDIEHYFLKEITKEELLTAKKVIEQLKQNMLTYKGDNDA"
     gene            3696..5402
                     /locus_tag="VHC05_000901"
     CDS             3696..5402
                     /locus_tag="VHC05_000901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402224.1"
                     /translation="MLKDAILRYKWYALGSFFMVIGVVASSLLQPHYLKSVLSAVIQN
                     NQEKIYEVGKPLLIIALLGLMSGAINTVLAAKIAQGVSADMREKTFRKIQDFSYANIE
                     AFNAGNLVVRLTNDINQIQSLVMMMFQILFRLPILFIGAFIMAVQTFPQLWWVIVVMV
                     ILIALIMGLVMRQMGPRFGKFQRLMDKINRIAKENLRGVRVVKSFVQEQQQYTKFKET
                     SNDLLALNLSIGYGFSLMQPALMLVSYLAVYVSINVVSTMVETDPTVIGNIASFMTYM
                     MQIMFSIIVVGSMGMQVSRAFVSMARIRQILSTEPAMTFENEKEETISGSIVFDDVSF
                     TYPNDDEPTLKHISFAIEPGQMVGIVGATGSGKSTLVQLIPRLFDPQDGQILLGGKPI
                     KILSQTTLRQSVSIVLQKAILFSGTIADNLRQGSAKADIDAMQKAAQIAQAKEFIDRM
                     DSRYESQVEERGSNLSGGQKQRLSIARGVINHPKILILDDSTSALDAKSEKRVQEALS
                     HKLEGTTTVIVAQKISSVVKADKILVLDQGQLIGEGTHAELVANNAIYREIYETQKGR
                     EE"
     gene            5405..7189
                     /locus_tag="VHC05_000902"
     CDS             5405..7189
                     /locus_tag="VHC05_000902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000859866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402225.1"
                     /translation="MKTARFFWFYFKRYRFSFTVIAVAVILATYLQVKAPVFLGESLT
                     ELGKIGQAYYVAKMSGQTHFSPDLSAFNAVMFKLLMTYFFTVLANLIYSFLLTRVVSH
                     STNRMRKGLFGKLERLTVAFFDRHKDGEILSRFTSDLDNIQNSLNQSLVQVVTNIALY
                     IGLVWMMFRQDSRLALLTIASTPVALIFLVINIRLARKYTNIQQQEVSALNAFMDETI
                     SGQKAIIVQGVQEDTMTAFLKHNERVRQATFKRRLFSGQLFPVMNGMSLINTAIVIFV
                     GSTIVLSDKSMPAAAALGLVVTFVQYSQQYYQPMMQIASSWGELQLAFTGAHRIQEMF
                     DETEEVRPQNAPAFTSLKEAVAINHVDFGYLPGQKVLSDVSIVAPKGKMIAVVGPTGS
                     GKTTIMNLINRFYDVDAGSITFDGRDIRDYDLDSLRQKVGIVLQESVLFSGTITDNIR
                     FGDQIISQDMVETAARATHIHDFIMSLPRGYNTYVSDDDNVFSTGQKQLISIARTLLT
                     DPEVLILDEATSNVDTVTESKIQRAMEAIVAGRTSFVIAHRLKTILNADHIIVLKDGK
                     VIEQGNHHELLHQKGFYAELYHNQFVFE"
     gene            7307..8074
                     /locus_tag="VHC05_000903"
     CDS             7307..8074
                     /locus_tag="VHC05_000903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase QueH"
                     /protein_id="HEQ5402226.1"
                     /translation="MIDLQEILANMNPNQKINYDRVMQQMAKVWAKESVRPSILMHVC
                     CAPCSTYTLEYLTQFADITVYFANSNIHPKDEYHRRAYVTQQFVSEFNAKTGNTVQFL
                     EADYVPNEYVRQVRGLEEEPEGGDRCRVCFDYRLDKTAQKAVELGFDYFASALTISPH
                     KNSQTINDVGIDVQKVYTTKYLPSDFKKNNGYRRSVEMCEEYDIYRQCYCGCVYAAKM
                     QGIDLVQVKKDAKAFMADKDLDNDFTHIRFSYRGDEM"
     gene            8184..8630
                     /locus_tag="VHC05_000904"
     CDS             8184..8630
                     /locus_tag="VHC05_000904"
                     /EC_number="3.6.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dUTP diphosphatase"
                     /protein_id="HEQ5402227.1"
                     /translation="MTKIRGFELVSSFTNNDLLPKRETTHAAGYDLSVAEAVTIAPGE
                     IKLVPTGVKAYMQDGEVLYLYDRSSNPRKKGIIMINSVGVIDADYYGNEANEGHIFAQ
                     MQNIIDHPVTLAVGERIVQGVFMPFLIADGDQARGERTGGFGSTGQ"
     gene            8711..10072
                     /gene="radA"
                     /locus_tag="VHC05_000905"
     CDS             8711..10072
                     /gene="radA"
                     /locus_tag="VHC05_000905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadA"
                     /protein_id="HEQ5402228.1"
                     /translation="MAKKKATFICQECGYQSPKYLGRCPNCSAWSSFVEEVEVKEVKN
                     ARVSLAGEKSRPVKLKDVDNISYHRTQTDMSEFNRVLGGGVVPGSLILIGGDPGIGKS
                     TLLLQVSTQLANKGTVLYVSGEESAEQIKLRSERLGDIDNEFYLYAETNMQAIRTEIE
                     NIKPDFLIIDSIQTIMSPDITGVQGSVSQVREVTAELMQLAKTNNIATFIVGHVTKEG
                     TLAGPRMLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEIGIFEMQSGGLVEVLNP
                     SQVFLEERLDGATGSAVVVTMEGSRPILAEVQSLVTPTVFGNARRTTTGLDFNRVSLI
                     MAVLEKRCGLLLQNQDAYLKSAGGVKLDEPAIDLAVAVAIASSYKEKPTSPQEAFLGE
                     IGLTGEIRRVTRIEQRINEAAKLGFTKVYAPKNALQGIDIPQGIEVVGVTTVGQVLKA
                     VFS"
     gene            10261..10758
                     /locus_tag="VHC05_000906"
                     /pseudo
     CDS             10261..10758
                     /locus_tag="VHC05_000906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888577.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="carbonic anhydrase"
     gene            10889..11599
                     /locus_tag="VHC05_000907"
     CDS             10889..11599
                     /locus_tag="VHC05_000907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00266 family protein"
                     /protein_id="HEQ5402229.1"
                     /translation="MVDNRMRFTIDQNMQFPLVEIDLEHGGSVYLQQGSMVYHTENVT
                     LNTKLNGKGSGLGKLVGAIGRSMVSGESMFITQAMSNGDGKLALAPNTPGQIVALELG
                     EKQYRLNDGAFLALDGSAQYKMERQNIGKALFGGQGGLFVMTTEGLGTLLANSFGSIK
                     KITLDGGTMTIDNAHVVAWSRELDYDIHLENGFMQSIGTGEGVVNTFRGHGEIYIQSL
                     NLEQFAGTLKRYLPTSSN"
     gene            11781..13226
                     /locus_tag="VHC05_000908"
     CDS             11781..13226
                     /locus_tag="VHC05_000908"
                     /EC_number="6.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012514887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate--tRNA ligase"
                     /protein_id="HEQ5402230.1"
                     /translation="MSKPIRVRYAPSPTGLLHIGNARTALFNYLYARRHGGTFIIRIE
                     DTDRKRHVEDGERSQLENLKWLGMDWDESPETHENYRQSERLALYQQYIDQLLAEGKA
                     YKSYVTEEELAAERERQEAAGETPRYINEFIGMSADEKAKYISEREAAGVVPTVRLAV
                     NESGIYKWTDMVKGDIEFEGGNIGGDWVIQKKDGYPTYNFAVVVDDHDMQISHVIRGD
                     DHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLSKRDTNTLQFIEDYRKKGYM
                     PEAVFNFIALLGWNPGGEEEIFSREQLIALFDENRLSKSPAAFDQKKMDWMSNEYLKH
                     ADFETVYALCKPFLEEAGRLTEKAEKLVELYKPQLKSADEIIPLTDLFFSDFPELTEA
                     EKEVMAGETVSTVLQAFKAKLEAMSDEDFKPENIFPQIKAVQKETGIKGKNLFMPIRI
                     AVSGEMHGPELPNTIYLLGRDKSIEHIKNML"
     gene            13621..14968
                     /locus_tag="VHC05_000909"
                     /pseudo
     CDS             13621..14968
                     /locus_tag="VHC05_000909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407280.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
     gene            14965..16248
                     /locus_tag="VHC05_000910"
     CDS             14965..16248
                     /locus_tag="VHC05_000910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEQ5402231.1"
                     /translation="MMVIYSMALFYATIFINSWVIFAKVSAIKLSWKRVSIIGISFVI
                     ANMIFDKVILIDQLFFIIVSLLSAPKKKLFEHMFNGFFTILIVELLFRVIGSFFLPAV
                     LGFSIGQINNNLKLLELCYLFVLPIFYLFSYIFSIDLSLIRFISEDKMKKWVFWMNTA
                     MFSYYFFAHFLVTVQSGFLALYFQYRSILVFIYLAIFIWVIVKLDRFAKDQLSQKLTQ
                     AQNERIAYLENYNQSIEQLYREIRTVKHDSENILISLKDSIDSGDIDLITRVYDTVIQ
                     QSATSMMRTNYEISSLDNIKEAVIRSIMNSKLLEAQYLGIELYIEIPDVIDHLPIKLI
                     DLIVLFTGLVDNAIETAKGSRRPFLSIAYFKQDNKQLFIIENSTKTNRVDIAKRFDAQ
                     QQNSAHFLTVLDSYPQITLSTKSDHYRLRQLLEMR"
     gene            16252..16992
                     /locus_tag="VHC05_000911"
     CDS             16252..16992
                     /locus_tag="VHC05_000911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5402232.1"
                     /translation="MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKL
                     FESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQKDPNAVIVFVTTHSEFAPISFKY
                     KVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
                     YFATATTPHKVCLWTRTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQ
                     LLYFENGDSCMVSRLKMKCLFERWEALR"
     gene            17532..17891
                     /gene="rnpA"
                     /locus_tag="VHC05_000912"
     CDS             17532..17891
                     /gene="rnpA"
                     /locus_tag="VHC05_000912"
                     /EC_number="3.1.26.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P protein component"
                     /protein_id="HEQ5402233.1"
                     /translation="MKKTYRVKREKDFQAIFKDGKSTANRKFVIYHLNRGQDHFRVGI
                     SVGKKIGNAVTRNAVKRKIRHVIMALGHQLKSEDFVVIARKGVESLEYQELQQNLHHV
                     LKLAQLLEKGFESEEKH"
     gene            17857..18684
                     /locus_tag="VHC05_000913"
     CDS             17857..18684
                     /locus_tag="VHC05_000913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HEQ5402234.1"
                     /translation="MRKVLRVKKNIKIARIVPLVLLLVACGRGEVTAQSSSGWDQLVY
                     LFARAIQWLSFDGSIGVGIILFTLTIRLMLMPLFNMQIKSSQKMQDIQPELRELQKKY
                     AGKDTQTRMKLAEESQALYKKYGVNPYASLLPLLIQMPVMIALFQALTRVSFLKTGTF
                     LWVELAQHDHLYLLPVLAAVFTFLSTWLTNLAAKEKNVMMTVMIYVMPLMIFFMGFNL
                     ASGVVLYWTVSNAFQVVQLLLLNNPFKIIAERQRLANEEKARRLRERRARKKAMKRK"
     gene            18696..19610
                     /locus_tag="VHC05_000914"
     CDS             18696..19610
                     /locus_tag="VHC05_000914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein jag"
                     /protein_id="HEQ5402235.1"
                     /translation="MVLFTGKTVEEAIETGLQELGLSRLKAHIKVISKEKKGFLGFGK
                     KPAQVDIEGISDKTVYKADKKATRGVPEDINQKNAPAVNSADVEPEEIKATQKLEAED
                     TKVVPLMPEESPAQTLSNLAETVTETKAQQPSIPVEESEVPQDAGNDGFSKDIEKAAQ
                     EVSDYVTKIIYEMDIEATVETSNNRRQINLQIETPEAGRVIGYHGKVLKSLQLLAQNF
                     LHDRYSKNFSVSLNVHDYVEHRTETLIDFTQKVAKRVLESGQDYTMDPMSNSERKIVH
                     KTVSSIEGVDSYSEGNDPNRYVVVSLQR"
     gene            19924..20058
                     /gene="rpmH"
                     /locus_tag="VHC05_000915"
     CDS             19924..20058
                     /gene="rpmH"
                     /locus_tag="VHC05_000915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L34"
                     /protein_id="HEQ5402236.1"
                     /translation="MKRTYQPSKIRRQRKHGFRHRMSTKNGRRVLAARRRKGRKVLSA
                     "
     gene            20333..21037
                     /locus_tag="VHC05_000916"
     CDS             20333..21037
                     /locus_tag="VHC05_000916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HEQ5402237.1"
                     /translation="MPDKPTKEKLMEQLKGGIIVSCQALPGEPLYSETGGIMPLLAKA
                     AQEAGAVGIRANSVRDIKEIQAITDLPIIGIIKKDYPPQEPFITATMTEVDQLAALNI
                     AVIAMDCTKRDRHDGLDIASFIRQVKEKYPNQLLMADISTFDEGLVAHQAGIDFVGTT
                     LSGYTPYSRQEAGPDVALIEALCKAGIAVIAEGKIHSPEEAKKINDLGVAGIVVGGAI
                     TRPKEIAERFIEALKS"
     gene            21086..22405
                     /locus_tag="VHC05_000917"
     CDS             21086..22405
                     /locus_tag="VHC05_000917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter substrate-binding
                     protein"
                     /protein_id="HEQ5402238.1"
                     /translation="MNMKKLASLAMLGASVLGLAACGGKSQKEADASKSDTAKTEITW
                     WAFPVFTQEKAEDGVGTYEKKLIAAFEKANPEIKVKLETIDFTSGPEKITTAIEAGTA
                     PDVLFDAPGRIIQYGKNGKLADLNDLFTEEFTKDVNNDKLIQASKAGDTAYMYPISSA
                     PFYMALNKKMLKDAGVLDLVKEGWTTDDFEKVLKALKDKGYNPGSFFANGQGGDQGPR
                     AFFANLYSSHITDDKVTKYTTDDANSIKAMTKISNWIKDGLMMNGSQYDGSADIQNFA
                     NGQTSFTILWAPAQPGIQAKLLEASKVDYLEIPFPSDDGKPELEYLVNGFAVFNNKDE
                     QKVAASKTFIQFITDDKEWGPKNVVRTGAFPVRTSYGDLYKDKRMEKIAEWTKFYSPY
                     YNTIDGFAEMRTLWFPMVQAVSNGDEKPEDALKAFTEKANKTIKKTQ"
     gene            22508..23395
                     /locus_tag="VHC05_000918"
     CDS             22508..23395
                     /locus_tag="VHC05_000918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001260031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEQ5402239.1"
                     /translation="MNVNKLKMRETLISYAFLAPVLVFFVIFVLIPMIMGFVTSFFNY
                     SMTDFTFVGFANYARMFQDPIFMKSLINTLIIVIGSVPVVVFFSLFVAAKTYDKNVVA
                     RSFYRAVFFLPVVTGSVAVTVVWKWIYDPMSGILNYVLKYAHVIEQNISWLGDKHWAL
                     LAIIVILLTTSVGQPIILYIAAMGNIDNSLMEAARVDGATEFQVFWNIKWPSLLPTTL
                     YIAVITTINSFQCFALIQLLTSGGPNYSTSTLMYYLYEKAFKLSEYGYANTMGVFLAV
                     MIAIISFAQFKILGNDVEY"
     gene            23408..24238
                     /locus_tag="VHC05_000919"
     CDS             23408..24238
                     /locus_tag="VHC05_000919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017767339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEQ5402240.1"
                     /translation="MTKKKLTASDILTAVMLCVLTILFIFPFYWIMTGAFKAQADTIM
                     IPPQWWPKAPTIENFKALVVQNPALKWLWNSVFISVATMFLVCGTSSLAGYALAKKRF
                     YGQRLLFSIFIAAMALPKQVVLVPLVRIVNFMGIHDTLAAVILPLVGWPFGVFLMKQF
                     SENIPTELLESAKIDGCGEIRTFFNVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLT
                     SRENLTISLGVATMQAEMATNYGLIMAGAAMAAVPIVTVFLVFQKSFTQGITMGAVKG
                     "
     gene            24258..24713
                     /locus_tag="VHC05_000920"
     CDS             24258..24713
                     /locus_tag="VHC05_000920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003060069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HEQ5402241.1"
                     /translation="MFYDRLKNISRYRGIHPHLDAAITFLQTTDLRQLAEGKYPILGE
                     KVFAVIQRNQLSKADNSLLEYHKRYADCHLLLAGNECIRYGIGNQAEVVPFEQEADIG
                     FVACDRTYDLDLVDDSFAYFFPNEPHQPNNFNQAGEAVTKCLIKVLMAD"
     gene            24757..25419
                     /locus_tag="VHC05_000921"
     CDS             24757..25419
                     /locus_tag="VHC05_000921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF624 domain-containing protein"
                     /protein_id="HEQ5402242.1"
                     /translation="MTSKKQGLLHSLFNLDSKWMRASAALFDLLVFNLLFVLSCLPLL
                     TIGVAKMAFYASLLDWREGQVSQLVTTYRSHFKYYFKSGLRLGLIELGIMSICLLDLF
                     LIRNQSGLVFQGFKVLCVAVLFLVVILFLYAYPQAVKRDLSLSTLFKRSFLLAGLFFP
                     WSFAFLTFICLTIFSLQLSLLTLFGGVSLLAIIGISSLTYLYLIIMESLLRRFPLNND
                     IE"
     gene            25431..26345
                     /locus_tag="VHC05_000922"
     CDS             25431..26345
                     /locus_tag="VHC05_000922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HEQ5402243.1"
                     /translation="MTDLTKYQGIIPAFYACYDDQGNISPERVRALTQYYIDKGVQGL
                     YINGSSGECIYQSVFDRQLVLENVMAVAKGKLTIINHVACNNTKDSIELAAHSERLGV
                     DAIAAIPPIYFRLPEYAVADYWNAISSAAPHTDFIIYNIPQLAGVALTPSLYKTMLAN
                     KRVIGVKNSSMPVQDIQTFCAIGGDDRIVFNGPDEQFLGGRLMGAAAGIGGTYGAMPE
                     LFLRLNQLIADKDLEKAKALQYTINEIIGVLVSAHGNMYGVIKEVLRINEGLDIGSVR
                     SPLAELVEEDRVICQRAAALINQAKETF"
     gene            26367..27305
                     /locus_tag="VHC05_000923"
     CDS             26367..27305
                     /locus_tag="VHC05_000923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEQ5402244.1"
                     /translation="MKHYLAIDIGGTAIKYGLISETGDLLEKEEMATEAYKGGPSILE
                     KVKGLVKTYQDQMDLAGVAISSAGMVNPDKGEIFYAGPQIPNYAGTQFKKEIEETFGL
                     PCEVENDVNCAGLAEAISGSAKDYPVALCLTIGTGIGGCLLFNSQVFHGSSHSACEVG
                     YLHLSDGQFQDLASTTALVQEVALAYGDDISQWDGRRIFEQAKAGDAICIAAISKQVD
                     YLGQGIANICYVVNPNVVVLGGGIMAQKDYLADKLKTALDSYLVSSLAKKTQLKFASH
                     GNNAGILGAYYHFKQKNERSCSFITLEKIENNLASS"
     gene            complement(27416..28246)
                     /locus_tag="VHC05_000924"
     CDS             complement(27416..28246)
                     /locus_tag="VHC05_000924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HEQ5402245.1"
                     /translation="MPKNHRLITKIEASLEHMTSLEKGIAHFFITTDLTPQELTASEI
                     VKRLHISQAALTRFAKKCGFTGYRAFAFDYLHSLQESQETFQSIHLELTKRVLMDYDA
                     LINKTYELVNEEKLLNLAKLIDSSERVYFFGKGSSGLVAREMKLRFMRLGLICDAYSD
                     TDGFTWANSLVNENCLVFGFSLSGKTNSVITALHQASQRGAKTVLLTTDNQTEFDDSL
                     DIIPVSSTHQLHYGNRVSPQFPLLIMMDIIYAYVLAIDKPHKEKIFKNTIIDKENNDL
                     "
     gene            28531..29322
                     /locus_tag="VHC05_000925"
     CDS             28531..29322
                     /locus_tag="VHC05_000925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HEQ5402246.1"
                     /translation="MTNKVEKLTIFDTHTHLNVAEFQGHETEELTLAQEMGVAYHNVV
                     GFDQATISGALTLANKYANIYATIGWHPTEAGSYSEAVEEAIVSQLSHPKVIALGEIG
                     LDYYWMEDPKEVQIEVFKRQMQLAKDHDLPFVVHTRDALEDTYEVIKAAGVGPRGGIM
                     HSYSGSLEMAERFIELGMMISFSGVVTFKKALDIQEAAQHLPLDKILVETDAPYLTPV
                     PKRGKQNHTAYTRYVVDKIAELRGMTVEEVAKATTANAKRVFKLD"
     gene            29294..29884
                     /gene="rnmV"
                     /locus_tag="VHC05_000926"
     CDS             29294..29884
                     /gene="rnmV"
                     /locus_tag="VHC05_000926"
                     /EC_number="3.1.26.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease M5"
                     /protein_id="HEQ5402247.1"
                     /translation="MQRGYSSLTEKINIQEVLVVEGKDDTANLRRFYEVDTYETRGSA
                     ITEEDLERINRLNDLRGVIVLTDPDYNGERIRKLIMAAVPTARHAFLNRNEAVPSSKS
                     KGRSLGVEHARFEDLQKALAHVTQQYDDESYFDIRQTDLIRLGLLMASDSRKRREYLG
                     EKLRIGYANGKQLLKRLELFGITLAEVEEVMETYEE"
     gene            29998..30870
                     /gene="rsmA"
                     /locus_tag="VHC05_000927"
     CDS             29998..30870
                     /gene="rsmA"
                     /locus_tag="VHC05_000927"
                     /EC_number="2.1.1.182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017649369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="HEQ5402248.1"
                     /translation="MRIADYSVTKAVLDRHGFTFKKSFGQNFLTDTNILQKIVDTAEI
                     DQNVNVIEIGPGIGALTEFLAENAAEVMAFEIDDRLVPILADTLRDFDNVQVVNQDIL
                     KADLQTQIKQFKNPDLPIKVVANLPYYITTPILMHLIESKIPFQEFVVMMQREVADRI
                     SAEPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRDQPLIEVED
                     EDFFFRVSRLSFVHRRKTLWNNLTSHFGKSEDIKAKLEKGLALADIKPSIRGEALSIQ
                     DFGKLADALKEVGL"
     gene            31296..32168
                     /gene="rsgA"
                     /locus_tag="VHC05_000928"
     CDS             31296..32168
                     /gene="rsgA"
                     /locus_tag="VHC05_000928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HEQ5402249.1"
                     /translation="MQGKIIKSLAGFYYVESEGQVYQTRARGNFRKRGETPYVGDIVD
                     FSAEDNSEGYILAIHPRKNSLVRPPIVNIDQAVVIMSAKEPEFNSNLLDRFLILLEHK
                     AIHPVVYISKMDLLDSPEEIKAIGRQYQAIGYDFVTSLEELLPLLADKITVFMGQTGV
                     GKSTLLNRIAPELALETGEISDSLGRGRHTTRAVSFYNTHGGKIADTPGFSSLDYDIA
                     NAEDLNEAFPELRRLSHECKFRSCTHTHEPKCAVKAALETGELWPVRYEHYLQFLSEI
                     ENRRETYKKVIKRK"
     gene            32178..32840
                     /locus_tag="VHC05_000929"
     CDS             32178..32840
                     /locus_tag="VHC05_000929"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HEQ5402250.1"
                     /translation="MSTLKIAPSILAADYANFASELARIEETDAEYVHIDIMDGQFVP
                     NISFGADVVASMRKHSKLVFDCHLMVVDPERYVEAFAQAGADIMTIHTESTRHIHGAL
                     QKIKAAGMKAGVVINPGTPATALEPLLDLVDQVLIMTVNPGFGGQAFIPECLEKVATV
                     AKWRDEKGLSFDIEVDGGVDNKTIRACYEAGANVFVAGSYLFKASDLVSQVQTLRTAL
                     NV"
     gene            32833..33465
                     /locus_tag="VHC05_000930"
     CDS             32833..33465
                     /locus_tag="VHC05_000930"
                     /EC_number="2.7.6.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine diphosphokinase"
                     /protein_id="HEQ5402251.1"
                     /translation="MSKVALFAGGDLSYISRDFDYFVGIDRGSLFLLENGLPLNMAVG
                     DFDSVPQKAFTDIKEKAELFITAHPEKNDTDTELALKEVFARFPEAEVTIFGAFGGRM
                     DHLLSNIFLPSDPGIAPFMAQIALRDQQNMLTYRPAGQHLIHQEEGMTYVAFMAEGEA
                     DLTITGAKFELTQDNFFKKKIYSSNAFIHQPITVSLPSGYLIIIQSKDWS"
     gene            33467..34738
                     /locus_tag="VHC05_000931"
     CDS             33467..34738
                     /locus_tag="VHC05_000931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombination protein RmuC"
                     /protein_id="HEQ5402252.1"
                     /translation="MDLILFLLVLVLLGLGAYLLFKVNGLQHQLAQTLEGNADNLSDQ
                     MTYQLDTANKQQLLELTQLMNRQQADLYQQLTDIRDVLHRSLSDSRDRSDKRLEEINQ
                     QVNQSLKNMQESNEKRLEEMRQIVEEKLEETLKNRLNASFDSVSKQLESVNKGLGEMR
                     SVAQDVGTLNKVLSNTKTRGILGELQLGQIIEDIMTSSQYEREFVTVSGSSERVEYAI
                     KLPGNGQGGYIYLPIDSKFPLEDYYRLEDAYEVGDKLAIEASRKALLAAIKRFAKDIH
                     KKYLNPPETTNFGVMFLPTEGLYSEVVRNAAFFDSLRREENIVVAGPSTLSALLNSLS
                     VGFKTLNIQKNADDISKILGNVKLEFDKFGGLLAKAQKQMNTANNTLDQLISTRTNAI
                     VRALNTVETYQDQATKSLLNMPLLEEENNEN"
     gene            34728..35666
                     /locus_tag="VHC05_000932"
     CDS             34728..35666
                     /locus_tag="VHC05_000932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003045335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exoribonuclease YhaM family protein"
                     /protein_id="HEQ5402253.1"
                     /translation="MKINQMKKDQLFEGFYLIKSAEVRKTRAGKDFISLTFQDDTGEI
                     SGNLWDAQPYNVEEFTAGKVVFMKGRREVYNGTPQVNQITLRNVRPGEPNDPKDFKEK
                     APVSVEEVRDYLEQMLFKIENATWQRIVRALYRKYDKEFYTYPAAKTNHHAFESGLAY
                     HTATMVRLADSIGDIYPDLNKSLLFAGIMLHDLAKVIELTGPDNTEYTVRGNLIGHIS
                     LINEEITKVISELQIDDTKEEVIVLRHVILSHHGQLEYGSPVRPRIMEAEIIHMIDNI
                     DANMMMMTTALSRVSEGEMTNRIFAMDNRSFYKPNY"
BASE COUNT        10650 a         6414 c         7736 g        11019 t
ORIGIN      
        1 ctagtttctt gtcagccttg aacctttttc ctaatttatg gtatgataag aagatgatga
       61 aaaaagagat tctcaaagaa ctcttctagt ctttacgaac tatggatgta gacttaaaac
      121 gtcaaaatga tcaagcttta ttagtggatg ttgttagcaa tcaagcttat cagcgggcca
      181 atacgattgc caaatcaaac gatttatgat attgctgttt aggaggttta tcttagatga
      241 cacggttatt aaaacgatat cctattacta ttttcctttt agggttaaca ggcttaattt
      301 ttatagcaat gcaagtggta tatggacatt tagcaactgg tgctcaagct atttatcaag
      361 ttggaggtat gtttggatta ctagtaaaag caatgccaga ccagttgtgg cgattggtga
      421 ctccgatatt tattcatatc ggctttggtc atttttttgt caatggatta acactatatt
      481 ttgttggtca aatcgtcgaa gacctctggg gctcacgccg ttttttatta ctttatgttt
      541 tatcaggtgt tatgggcaat gcctttactt tttggttgac tcctgaaaca gtagctgcag
      601 gagcatcgac gtcgttattt ggactttttg ctgctattgt agtattgagt tttttgggta
      661 agaaccaagc gttgaaagat ttgggcaagt cataccaaac gttaattgta gtcaatttac
      721 tgatgaatct ttttatgcca aacgtgagta tggcaggcca tattggcggt gtcgtgggtg
      781 gtgcgttact gagtatagtt tttccaacta agatgagagt gataacagtg aagaaaacca
      841 agcgaatgtt ggctttagtg agctatggta ttattttggt tggtgtgtta gtgcttgggt
      901 ttttataaaa ataagtgagt ggttagcact gttacttctc agatggctag taggatgaaa
      961 tgactcaaaa accataaaaa ataaggaggg attttccctc cttattttta tggttttgtt
     1021 ttctctagag ctttgcccag ttggatgatg taggctttca agtcatcttt gacttggggg
     1081 tgtttcaggg cataatccaa agaagttttc ataaacccaa atttatcgcc aacatcatag
     1141 cgtttccctt taaactcacg agcaaagaca cgctgtgtct tattgagggt atcaatagca
     1201 tcagtcagtt gaacttcatt gcctgcacca ggttcttgtt tttctaaaat actaaaaatt
     1261 tctggtgtga gcaagtaacg tccaataatt gccaaatcac taggtgcatc ttgaggttgt
     1321 ggtttttcaa caaaagtatc cacactatag agtcctttta ctgcttttgc ttgaggagca
     1381 atgataccgt agttagagac atcctcgtga ggaaccctca tgacggcaat agttgcagca
     1441 tgagtttctt catagtcatc gatcaattgt ttggttaatg gttttacatt tggatttgta
     1501 atatccatca gatcatcacc tagcatgaca acaaaaggtt cattgccaac aaaggtcttt
     1561 gcttgaagaa ctgcgtctcc taatcctctt ggatgactct gtcgaataaa gtgaaggtta
     1621 atagaagtgg tctcgtctac taactttaga agttcgattt ttcctttagc ctgtaaatta
     1681 tattctaatt caaaattaga atcaaaatga tcttctatgg agcgtttgga ttttccagta
     1741 acgataagaa tttcttcgat acctgatttt agagcttctt caacgataaa ttgaatagtt
     1801 ggtttatcaa caataggtag catctccttg gcaagggcct tggttgcagg taaaaaacgt
     1861 gtgcctaaac ctgctgcggg aataatagct tttctgactt tggtcatcag cacctccttt
     1921 tattttagtg acgcatggct taatgccatt cattttcaga acgaaattca tttgacatca
     1981 tgccgaggat gctttctttg atatcagcgc cctcgtagat ggacttataa atagctgttg
     2041 taattggcat gtaaactccg aggtcttggg caatttcata ggctacctta gttgttgcga
     2101 tgccttcgat aaccataccc atgttgcgtt caatatcttc taatttttca ccacgtccaa
     2161 gggcagctcc agcccgccag ttacgtgaat ggacagaagt acctgttaca attagatcac
     2221 caacaccaga taacccactg taggttaacg ggtcagcacc aagcttgacg cctagacggg
     2281 tgatttcagc taacccacga gtaattaccg ctgctttggc attatctcca tacccaagtc
     2341 catggagagc tcctgctcca acagcaataa tgtttttgag ggcaccagct gtttcaactc
     2401 cgatgacgtc ggtattggta taaagtcgga agtagtggtt actaaagagg gactgaacat
     2461 actttgcagc ttcaatatct tttgaggctg ccgtgatgag agtaatatcg cgaacgatag
     2521 tttcttcagc atgactagga cctgatacaa cgaccacttc actacgaaaa tgagctggaa
     2581 tttcttcttc taggatagtt gataaacgtt cgtgggtctc tggttctaga ccttttgagg
     2641 catgcatgac cactacttta tgatctaaaa tggcggcaac ttgtctagca actaatcgtg
     2701 ttactttagt tggcacaaca aaaagcaccg catcaacatc tgatagggct tgacctaaat
     2761 caagagttgc cgtaatgttt ttgtctaaca cgatgtcttt gaagtagtgt ctattggtat
     2821 gcttggtatt tatttcttca atttgatcag gaatatttcc ccataaacgg acgtcatggc
     2881 cattgtcatt aagaacctga gaaagagcag ttccccaaga accaggtcct aaaatagcta
     2941 ctttttgttt tgtcattcta aattctcctt caagagctag tcactctatt ataacataac
     3001 accttgatta gctctattag aaaaggtata tggtcttggc taataaggcg ttcccaagag
     3061 agctagctat attaataatg ttgtttaata agcttcatca ggtgagcggt tgtcatggct
     3121 ttgccctgtt ctttttagtt atttaagttc ggaaacttat ttttaaaaat aaagatattt
     3181 taattgacaa tagttatcta gagaactaaa atacttatca tagaaactat taaggaaaag
     3241 aaggagggaa gagatgtcac aagtgatagg tgatttacgt gaattgatac atcaaatcga
     3301 acaaattagt gatgagattg caaaaaaata tgatgtagag catctagcag gtcctcaagg
     3361 ttatgttctt gtttttttag ctaaacacca aaatcaagaa atatttgtca aagatattga
     3421 aaaacaactt cgtatctcaa agtcagttgc tagtcattta gtgaaacgta tggtcaaaaa
     3481 tgggtttatc aatgtgatgc cttcccaagt ggataagcgt tataagcaag tagtgttagc
     3541 gcaggttggt agagataaat tgcctttgtt gcgggagtgt cgtaaggata tcgagcacta
     3601 ttttttaaaa gaaattacaa aagaagagtt gctgacagcg aaaaaagtaa ttgaacagct
     3661 caagcaaaat atgctaactt ataaaggaga caacgatgct taaagacgca atcttacgtt
     3721 ataaatggta tgctttaggc tcatttttta tggttattgg ggttgttgca agtagtctct
     3781 tgcaaccaca ttatcttaaa tctgtgctaa gcgctgttat tcaaaataat caagagaaaa
     3841 tttatgaggt tgggaaacca ttacttatta ttgccctttt agggttaatg tctggagcga
     3901 ttaatacggt tttagctgct aaaatagctc aaggtgtatc tgctgatatg agggagaaga
     3961 cctttcgaaa aatccaagac ttttcatatg ccaatattga agcttttaat gctggtaatc
     4021 ttgtggttag gctaactaat gatatcaatc aaatccaaag tttagtcatg atgatgtttc
     4081 aaattctctt tcgtttgccg atccttttta ttggcgcgtt tattatggca gttcagacat
     4141 tccctcaatt atggtgggtc attgttgtaa tggttatctt aattgccctc atcatgggtt
     4201 tggtgatgcg tcaaatgggt cctcgttttg gtaaatttca acggttaatg gataagatta
     4261 atcgcatcgc taaggaaaat ctccgtggcg ttcgcgtggt taaatcattt gtacaagaac
     4321 aacaacaata cactaaattt aaagaaacgt ccaatgatct tttggcgtta aatttatcta
     4381 ttggttatgg tttttcacta atgcagccgg ctttaatgtt ggtgtcttat ttggcagttt
     4441 atgtttctat aaatgttgtt tcgaccatgg tcgaaacaga tccaacagtg attgggaata
     4501 ttgcctcttt catgacttat atgatgcaaa ttatgttttc aattattgtg gttggttcca
     4561 tggggatgca agttagtcgt gcttttgttt ctatggctag aattaggcaa atattgtcta
     4621 cagaacctgc catgacattt gaaaatgaaa aggaagaaac catctcagga agcattgtat
     4681 ttgacgatgt tagttttaca tatcctaatg atgatgagcc aaccttgaag cacatttctt
     4741 ttgctattga acctgggcaa atggtcggca tcgttggtgc aacaggatct gggaaatcaa
     4801 cgcttgtaca gctcatccct cgcttatttg atcctcaaga tggccaaatt ttgttaggag
     4861 gaaagccgat taaaatccta agtcaaacaa ccctgcgcca atcggtttcc atcgtgttgc
     4921 aaaaggctat tctcttttca ggaacgatag ctgataacct tcgccaaggc tcagcaaaag
     4981 ctgatattga tgctatgcaa aaagccgctc aaatcgcgca agcaaaagaa tttattgatc
     5041 gcatggatag ccgttatgag agccaagttg aagagcgagg tagtaacttg tctggcggac
     5101 aaaagcaacg tctgtctatt gcacgtggtg tcattaatca tcccaaaatc cttatattag
     5161 acgattccac ttcagctctt gatgcaaaat ctgaaaaacg cgttcaagaa gccttaagtc
     5221 ataaattaga aggtacaact acagttattg ttgctcaaaa aatttcatcg gtagttaagg
     5281 cagataagat cttagtcctt gaccaaggac agttaattgg agaaggaaca cacgcagagt
     5341 tggtggctaa taatgcgatt tatcgtgaaa tttatgagac acaaaaagga agggaggagt
     5401 agtgatgaaa acagcacgtt ttttctggtt ttattttaaa cgctatcgtt tctcatttac
     5461 tgtcattgct gttgccgtta tcttagcaac ttatttacaa gtaaaagctc ctgtcttctt
     5521 aggagagtcc ttgactgagt tgggaaaaat cggtcaggct tattacgttg ctaagatgag
     5581 tggtcagaca cattttagcc ctgatttatc agcttttaat gccgtgatgt ttaagctttt
     5641 gatgacttat ttctttactg ttttagctaa tctaatatat agtttcttac ttacacgtgt
     5701 tgtctcacat tcgaccaacc gcatgcgcaa gggcttgttt ggtaaattag aacgtttaac
     5761 cgtcgccttt tttgaccgcc ataaagatgg ggagattctt tctcgtttca cgagtgattt
     5821 ggataatatt caaaactcgc tgaaccaatc cttggttcaa gtggtgacta atattgccct
     5881 ttacatcggc ctggtctgga tgatgtttag gcaagatagc cgtttagctt tgttaaccat
     5941 cgcatcaacc ccagttgctc tcattttttt agtgattaac atccgtttgg caagaaaata
     6001 caccaatatc caacagcaag aagtcagtgc tttaaatgct tttatggatg aaaccatttc
     6061 aggacaaaag gctattattg tacaaggtgt ccaagaagat acgatgacag cctttttaaa
     6121 gcataatgaa agggttcgac aagccacttt caaacgccgt ctgttctcag gacaattatt
     6181 tccagtcatg aatggaatga gccttattaa cacggctatc gtgatttttg tcggttcaac
     6241 aattgtcctc agtgacaaat ctatgccagc agcggcagcg cttggtttag tggttacttt
     6301 tgtacaatat tcccagcaat attaccaacc catgatgcaa atcgcgtcta gttggggaga
     6361 attgcagctg gcctttaccg gtgctcaccg tattcaagaa atgtttgatg aaaccgaaga
     6421 agttcgtcca caaaatgcac cagcgttcac cagcttaaaa gaagcagtgg ccatcaacca
     6481 cgttgatttt ggttaccttc ctgggcaaaa agtcttatcg gatgtatcta tcgtggcacc
     6541 caagggcaaa atgattgccg tggttggacc gacaggttct ggaaagacca ctattatgaa
     6601 cttgattaac cgtttctacg atgtggatgc aggttcgatt acctttgatg gccgtgatat
     6661 tcgtgactac gatttggata gtcttcgcca aaaggtaggg attgtgttgc aagagtcagt
     6721 tcttttttca ggaactatta cggataatat tcgttttggt gatcagatca ttagtcaaga
     6781 catggttgaa actgctgcgc gtgcgaccca tattcatgac tttatcatgt ccttaccaag
     6841 agggtacaat acctacgtct cagatgatga caatgtcttt tcaacaggtc aaaagcagtt
     6901 gatttctatt gctaggacgc tactgacgga ccctgaagtg ttgattttgg atgaggccac
     6961 ttcaaatgtt gatacggtta ccgaaagtaa aattcaacgg gccatggaag ctatcgtggc
     7021 aggtcgaacc agctttgtca ttgctcaccg cctcaaaacc attttaaatg ccgatcacat
     7081 tattgtgttg aaagatggca aggtcattga gcaaggaaat catcatgagc tattgcatca
     7141 aaaaggcttt tatgccgaat tgtatcacaa tcaatttgtc tttgaataga tggcatcagc
     7201 tccgcgtctt agcggagttt tttggtgaac aataaagcag tcaagctttc tttcctgata
     7261 tggtataata gcaagcaaga gaaaaaacaa ttagaaagta gccacaatga ttgatttaca
     7321 agagattctc gctaacatga atcccaatca aaagataaat tatgacaggg tcatgcaaca
     7381 gatggccaag gtttgggcta aggaatccgt gcgccccagt attttaatgc atgtctgctg
     7441 cgccccatgc tccacttaca ccctagaata cctgacgcag tttgctgaca ttacggttta
     7501 ctttgccaat tctaatattc accctaagga cgaataccat cgcagagctt atgtgacaca
     7561 acagtttgtc tccgagttca acgctaaaac aggcaatact gttcagtttc tcgaagcgga
     7621 ctatgtcccc aatgagtacg ttcgacaagt gcgaggttta gaagaggaac cagaaggtgg
     7681 ggaccgttgc cgtgtctgtt ttgattaccg actagacaag accgcccaaa aagcagtgga
     7741 actaggtttt gactactttg ccagtgccct aaccatcagt cctcataaaa attcgcaaac
     7801 cattaatgat gtgggcatcg atgtgcaaaa ggtttacacc accaaatacc tgccaagtga
     7861 tttcaagaaa aacaacggtt atcgcagatc cgttgaaatg tgtgaggagt atgatattta
     7921 ccgtcaatgc tattgtggct gtgtctatgc tgccaaaatg caaggtattg acttggttca
     7981 agtgaaaaaa gatgccaaag cttttatggc agacaaggat ttggataatg atttcaccca
     8041 catccgcttt agttatcgtg gggatgagat gtgatggcat gattaaaagt ggtccgttta
     8101 aagttgaccg cttttttgct attcttttac gaatagtcta taataagagg atatgattga
     8161 cttgaaagga tatacctatc ataatgacaa aaattcgtgg tttcgagctt gtttcaagct
     8221 ttactaataa tgatttacta ccaaaacgtg agacgactca tgcagctggt tatgacctgt
     8281 ctgttgctga ggctgtaacc attgccccag gggagattaa gttggtacca acaggggtta
     8341 aggcctatat gcaagatggt gaggtgcttt acctctatga tcgttcgtca aatccacgaa
     8401 aaaaagggat tatcatgatt aattcagtag gtgtgattga tgcagattat tatggcaatg
     8461 aggctaatga aggacatatt tttgcacaaa tgcaaaacat tatagatcac cctgtgacat
     8521 tagctgtggg tgagaggatc gttcagggtg tttttatgcc ttttttaatt gctgatggtg
     8581 accaagccag aggtgaacga acaggtggtt ttggttcgac agggcagtaa agcgatttaa
     8641 caaaaatgct tatgacagca gacctattct ttaagagtgg gtttgtcttg tctaggggag
     8701 ggagattact atggcaaaga aaaaagcaac ctttatctgt caggagtgtg gctaccagtc
     8761 gccaaagtat ttagggcgct gtccaaattg ctcggcctgg tcttcttttg tggaagaagt
     8821 agaggtcaaa gaagtcaaaa atgcccgtgt tagtctagct ggagaaaagt ccagaccggt
     8881 taaactaaaa gatgtggata atattagtta tcacagaaca cagactgaca tgtctgaatt
     8941 taatagagtt cttggagggg gtgtggttcc tggaagcttg attttaattg gtggtgatcc
     9001 aggtattgga aaatccacct tactcttgca ggtatccacg cagctcgcta ataagggaac
     9061 ggttctctat gtgtctgggg aagaatcagc agagcagatt aaactgcgga gtgagcgtct
     9121 gggtgatatt gacaatgaat tttacctcta tgccgaaacc aatatgcaag ctattcgcac
     9181 agaaattgaa aatattaaac cagatttttt aattattgac tccattcaga ctatcatgag
     9241 ccctgatatt acaggtgttc aaggatcagt cagtcaggtg agagaagtca ctgcagaatt
     9301 gatgcagctt gcaaagacga acaacattgc aacctttatt gtgggtcatg tcaccaagga
     9361 aggaaccttg gctgggcctc gtatgttaga acatatggtg gataccgttc tctactttga
     9421 aggggaaagg catcatactt ttcgcatctt gcgggctgtg aaaaaccgct ttggctccac
     9481 taacgagatt ggcatttttg aaatgcagtc tggcggcttg gtagaggtct taaatcctag
     9541 tcaagtcttt ttagaggaac gcttagatgg ggcaacagga tcggctgtcg ttgtaacgat
     9601 ggaaggaagt cgtcctatct tagcagaggt gcaatcttta gtgacaccaa ccgtttttgg
     9661 caatgccaga cgaaccacta cgggacttga tttcaatcgc gtaagcctaa taatggcagt
     9721 tttagaaaag cgctgtggtt tactcttaca aaatcaagat gcctacctca agtcggctgg
     9781 tggtgtcaaa ctagacgaac ctgccattga tttggcagtc gctgtggcta tcgcatccag
     9841 ttataaggaa aaaccaacca gccctcaaga agctttctta ggcgagatcg ggttaacagg
     9901 tgagattcgg cgagtgaccc gtattgagca acggattaat gaagcagcaa agcttggatt
     9961 taccaaggtc tatgctccta aaaatgcttt gcaaggcatt gatatccctc aaggtattga
    10021 ggttgtcgga gtgactacgg ttggtcaggt tttaaaggca gtttttagct agaggatcag
    10081 aaactaagag caaatgagga ggaaatttgt caagaaagta tcccaatcat ttgttttttt
    10141 aacttttcga acgataccgg ccgtctaaga ggttaatcca gctattttcc ataaaagatg
    10201 ttaagataag acaaactaac agcaaaaata gctctgctgt ttctcaaaag gagtttattg
    10261 atgtcttatt ttgaacattt tatggctgcc aattaggctt atttggcctt gcatgggaca
    10321 gctcatttgc ccttaaaacc caagactaaa gtagcgattg tgacttgtat ggattcacgg
    10381 ctacatgtgg cccaagctct ggggctggct ctaggagatg ctcatatttt aaggaatgct
    10441 ggcggacgtg tcaccgaaga catgattcgg tcgctggtta tttctcagca gcaaatggga
    10501 acgagagaga ttgtggttct ccaccataca gattgtggcg cgcagacttt tactaatgaa
    10561 ggctttgcca agcatattca tgagcactta ggtgtggatg tttcagggca agatttcctt
    10621 cccttccaag atgtggaaga cagtgtccgc gaggatatgg ctaagataag agcctcctct
    10681 cttatctctg atgacgtcgt tattaacggt gccgtctacg atgtggatac tggaaagatg
    10741 acacaagtaa tggaatagtt agtagccaag ttgtggagct gaattcagct cttttttatt
    10801 tttaaaaatt attgaaaata ttagacaaag aaatagggaa gcgttataat aattgtatca
    10861 agttattcat acaaacaagg agagtaagat ggtcgacaat agaatgagat ttacgattga
    10921 tcaaaacatg caatttccac tagttgagat tgatctggaa catgggggat cagtttactt
    10981 acaacaagga agtatggttt atcatactga gaatgtaacc ttgaatacca aattgaatgg
    11041 taagggatct ggtttaggaa aattagttgg agccatcggc cgttccatgg tttctggtga
    11101 atcaatgttc attacacaag ctatgtcaaa tggagatggt aaattagcat tagcacccaa
    11161 tacaccagga cagattgttg ctttagaact aggtgaaaaa caatatcgtc taaatgatgg
    11221 tgcctttcta gccctagatg gttcagcaca gtacaaaatg gaacgtcaaa atattggaaa
    11281 agcacttttt ggtggtcaag gcggactttt tgtcatgaca actgaaggct tgggtacctt
    11341 acttgctaac tcgtttggat ctatcaagaa aatcacactt gatggtggca caatgactat
    11401 tgataatgcc catgttgtag catggagcag agaacttgat tatgatattc atttagaaaa
    11461 tggctttatg cagtcaattg gtacaggtga aggagttgtt aataccttta gaggtcatgg
    11521 tgagatttat atccaaagtc ttaaccttga gcaatttgct gggactctta aacgttatct
    11581 accaactagt tcaaattagt caaaataaca taaaatcagc tttttagggc tgattttttt
    11641 cgcctaagca agtaaaatat gctataataa gaaagatttt agaagaagtc tgaaaaggtc
    11701 ttggcaagct caaatcatca tttgttgctt gtttttcgtg ccacaggttt ctgagtgata
    11761 tatgtaacag gagaagaagc atgtctaaac caattcgtgt gcgttatgca ccaagtccaa
    11821 cagggctttt acatatcggg aatgcccgca cagccctatt taattacctt tatgcccgtc
    11881 gtcacggagg tacttttatc attcgtattg aagatactga ccgtaaacgt catgttgaag
    11941 atggtgaacg ttctcaactt gaaaacctaa aatggttagg aatggattgg gatgaaagcc
    12001 cagaaacgca tgaaaattac cgccagtctg aacgtctagc actttatcaa caatatattg
    12061 atcaattgtt agctgaagga aaagcctaca agtcttacgt gactgaggaa gaattggcag
    12121 cagagcgtga acgccaagaa gcagctggcg aaacgcctcg ctatatcaat gaatttattg
    12181 gtatgtcagc tgacgaaaaa gctaagtaca tttcagagcg tgaagcagca ggtgtcgttc
    12241 caacagtccg tcttgctgtt aatgagtccg gtatttacaa atggactgac atggttaaag
    12301 gcgatatcga gtttgaaggt ggtaacatcg gtggtgactg ggttattcaa aagaaagatg
    12361 gctacccaac ttataacttt gccgttgttg ttgatgatca tgatatgcaa atttctcacg
    12421 ttatccgtgg cgatgaccat attgccaata cgccaaaaca attgatggtc tatgaagctc
    12481 ttggctggga agcgccagag tttggtcata tgactcttat catcaattct gaaacgggta
    12541 aaaaattatc aaaacgcgac accaataccc tccaattcat tgaagattac cgcaaaaaag
    12601 gttatatgcc tgaagctgtc tttaacttca tcgcccttct tggctggaat cctggcggag
    12661 aagaggaaat cttctctcgt gagcaactga ttgccctttt tgatgaaaat cgccttagca
    12721 agtcgccagc tgcctttgac cagaagaaaa tggattggat gagcaatgag tatcttaaac
    12781 atgcggattt tgaaacagtt tatgccctct gcaaaccatt ccttgaagag gcaggccgtt
    12841 tgacagaaaa agctgagaag ctagtagaat tatacaaacc tcaattaaaa tctgcagatg
    12901 agattattcc attgactgac cttttctttt ctgatttccc tgaattaaca gaagccgaaa
    12961 aagaagtgat ggcaggtgaa acagtttcga cagtcttgca agctttcaag gctaagttgg
    13021 aagctatgtc agatgaagac ttcaaaccag aaaatatttt cccacaaatt aaggctgttc
    13081 aaaaagaaac aggaatcaaa gggaaaaacc tctttatgcc tattcgtatt gcagtatctg
    13141 gtgaaatgca tggcccagaa ttaccaaata cgatttattt attgggacgt gataaatcca
    13201 ttgagcacat caaaaacatg ctataaggct gtatcgttca cctttatttt taaacgcttt
    13261 aaggagttaa aaagtcacga caacgaaaga ttgaagatta agttcttcag tcttttttat
    13321 cgttatctga gcttgctacc ttggtaaagt aaaaaatagt atagtttatt tctattttgg
    13381 agattggatt tgaaagagag gtggtgagat gcttacgtga taatgacagc aaacggtgag
    13441 gttttgatta gtgtgattta aagaaatggt ttttatgaat caattagtgt acaatatttt
    13501 tttggtatat gctgaaagag actagtttag tactcactta gctaatcaat tgtaatcaaa
    13561 taatattgta atcattgtca taaaatatgc taaaataata aagttggaaa ggagaaaaaa
    13621 atggctaata gcgaatatat gtttttatta ttatcaatta ttgtctatta tatgacaaaa
    13681 atttatattt tttcctttct atctgatatc acattaccag tttggaaaca actaacgatt
    13741 ttggctttag ccctattttt caatcagttc ccgtatttgt cgccattgtt aattgatcct
    13801 ctattatttt tagttgtttt aaggcaagaa accaagcaat tattttcttt gaaagctctt
    13861 tttttggctg ttgcacctag tgttttggtg gatttgctat ctcgatttat gggtacaatc
    13921 gttatcccct atcttttttt gtcgagtggt atttatctgg gtcatattat ctttgacttg
    13981 cttgcttatc tgctgatttt tccaagtttt gctattatta attatatgat tggaaaagat
    14041 tacaagatga tatgccaatc cggatattcg aaacgatcgc ataatttcta tcaaacattg
    14101 ctgatttttg ttttggttta ttatgtggac atttttgtca ttttaggatt tacggacccc
    14161 tttttacatt ttcatcattc tctttttgtt cccacacctt ataagttatt gtttttgatg
    14221 tttatacttc ttttagttta tcttctatct tattttaatc atagttctaa agaatacctt
    14281 aaaactgagt tgagaagaga acaacaagct tatatgacta acttagagac ttatgggaaa
    14341 catcttgaga aactctatcg agatgtaaga gcttttcaaa gtgattacct gagccgtata
    14401 gagcgtttag gtcaagccat taagagtgaa tccattactc agattcaaga tatttatgcc
    14461 caaacggttc atgaagctaa cgactactgg gatgataaac actataatat ctcgaagctt
    14521 aggaaaatta atatctcatc gattaagagc ttattgtcag ctaaaattat cagtgcggaa
    14581 aaatcaggta ttgatttgaa tgtggaagtg ccagataata taaaagagac ttacattcct
    14641 gagttggact tactattgtt gatgtctatt ttttgtgata acgccattga ggcagctctt
    14701 gaagcacagc aacctcatat gtcaattgct tactttttgt tagatgacta tcagatgttt
    14761 gttgtgacaa atacgactaa aaaaaaaggt agacattaac aagatctttg aagaaggcta
    14821 ttcttcaaaa ggctcagaac gtggtatcgg cctttctaat gcgcagcgta ttctcaaaaa
    14881 gtatccttat ttatccttgc ggactaaaag ttttgataag gaatttagcc aaaccttgac
    14941 catgccaaag gaggaggtgg atagatgatg gttatataca gtatggcttt attctatgct
    15001 accatcttta ttaacagctg ggtcattttt gcaaaggttt ctgctattaa actaagctgg
    15061 aaacgggtta gcattatagg cattagtttt gtaattgcta atatgatatt tgacaaagtc
    15121 attttgattg accaactgtt ctttattatt gttagtttgt taagtgctcc gaaaaagaaa
    15181 ttatttgagc atatgtttaa tggtttcttt actatcttga ttgtcgaatt actgtttcgc
    15241 gtcatcggat ctttcttttt accagctgtc ttaggattta gcattggtca aattaataat
    15301 aaccttaagc ttttagagtt atgttatctt tttgtattac caatatttta tctgtttagc
    15361 tacattttca gtattgactt aagcttaata aggtttatca gtgaagataa gatgaaaaag
    15421 tgggtatttt ggatgaatac tgccatgttt tcttactact ttttcgccca ttttttggta
    15481 actgtgcaaa gcggatttct tgcactatat ttccagtacc ggtctatttt agtatttatt
    15541 tatttagcta tttttatttg ggttattgtg aaattagatc gatttgctaa agatcagctg
    15601 tcacaaaaat taacacaagc acaaaatgaa cgtattgcgt atcttgaaaa ttacaatcaa
    15661 tcgattgagc aactttaccg agaaatcaga acagttaaac atgattctga aaatatttta
    15721 attagtttaa aagatagtat cgatagtggt gatatagatc tgattactag agtttatgac
    15781 acggttattc agcaatcggc aacttctatg atgcgcacaa attatgaaat atcttcttta
    15841 gacaatatca aagaggctgt gattcgcagc atcatgaatt ccaaattgct tgaagctcag
    15901 tatttgggta ttgaacttta tattgagatt ccagatgtta tcgatcattt acctattaag
    15961 ttaatcgatt taattgtact ttttactgga ctagtggaca atgctattga gacagccaaa
    16021 ggcagtagac gtcctttttt atctattgca tactttaaac aagataacaa gcaattattt
    16081 attattgaaa atagcacaaa aaccaatcgt gtggatatag ccaaacgctt tgatgctcag
    16141 cagcagaact cagcccactt tttgactgtt ttagatagtt acccccaaat aacgctttcg
    16201 actaaaagtg accattatcg attaagacaa ttgttagaaa tgagataaag tatgatgaac
    16261 atttttattc ttgaggatga ttttatccag cagacacgca tagaatctat cgtagtaggc
    16321 atcttaaaag agactagaat accatgtaat cagcttgaag tgttctcgac tcctcaaaaa
    16381 ttatttgaga gtatccaaga aagaggagac catcagctgt attttttaga tattgaaatt
    16441 ggtgaatata ctcgttgtgg gcttgaatta gctgcagcta ttcgacaaaa agatcctaat
    16501 gccgttattg tgtttgtcac cactcattca gaatttgctc ctatttcttt taaatataag
    16561 gtatccgctc tagattttat tgataaagca ggtggtcaaa aacagtttaa agaacaaatc
    16621 gaagaatgta tccgatatac ttacgatatg atgtctagtc gtgagtcaaa ggacatgttt
    16681 ttatttgaga ctccacagac aagattaaaa ttgccctata aggatatttt atactttgct
    16741 acagccacaa ctcctcacaa agtttgttta tggactcgga cagaaagatt agagttttat
    16801 ggtaatctat ctgagattca agcagtggca ccgaaacttt ttttgtgcca tagatcctac
    16861 cttgtgaatc tagataaggt tgttcgaatt gataagagta agcagctcct ttatttcgaa
    16921 aatggtgatt cttgtatggt atcacgatta aaaatgaaat gtctgtttga acggtgggag
    16981 gctcttcgct aaagttaaga gagcaataac attttaggac gaaaaagcaa catttcagga
    17041 aatgatgctc ttattgaaac atttttcgct ataataatta atgtaaataa agatttacga
    17101 agtcatgagt ttatcgagca atcaatcccc aattcaatca aaatattgtt ttctctctct
    17161 ccataaacaa atagtatttt tgatatgatg gctcggcaga caaaatgacg atgtcagttg
    17221 tctttgtttg gatatcacat tagctggttg taaaatcagt attaaagccc ggcttgccgg
    17281 gttttttgat aggtaaatac agggataagt agctgacgtc ttgtggattc tgacttttta
    17341 tggttgtttt ctgaaggtta ttcctttgtc gaaagaagaa ctatattacg aaaagatgga
    17401 gtgacaagag gcagttgaag cacaaaaact agaaatagta cagaaagagg cttaatctga
    17461 aagggttagg gctttttaat tttttagggg atgtggtata atggtaataa tttagatatt
    17521 ggagttaaat tttgaagaag acctatcgtg tcaagcgtga gaaagatttc caagccatat
    17581 ttaaggatgg aaaaagtaca gcaaatcgaa aatttgtcat ttatcattta aatagaggcc
    17641 aagaccactt ccgtgtgggt atttctgtcg gtaaaaaaat aggaaatgca gtcaccagaa
    17701 atgcagtcaa acgaaagata cgtcatgtta tcatggcatt agggcatcag ctgaagtcag
    17761 aggatttcgt ggtgattgcc cgtaagggtg tcgagtcttt ggagtatcaa gagcttcaac
    17821 aaaatttaca tcatgtttta aagttagcac aattgcttga gaaaggtttt gagagtgaag
    17881 aaaaacatta aaattgcaag aatagtcccc ttagttctat tattagtggc ctgtggtcgt
    17941 ggtgaggtaa cggcacaatc atctagtggt tgggaccagt tggtttactt atttgccaga
    18001 gcaattcaat ggctttcctt tgatggttca attggtgttg gcattattct ttttaccctt
    18061 actatccgtc tcatgctcat gcctttgttt aatatgcaaa tcaaatcaag ccagaagatg
    18121 caagacatcc aacctgagct tagagaattg caaaagaaat acgctggtaa agacacacaa
    18181 acgcggatga agttggctga agaaagtcaa gccctttaca aaaaatatgg ggttaaccct
    18241 tatgctagcc tcttacccct cttaattcag atgccagtta tgattgccct attccaagcc
    18301 ttgacacggg tatctttctt aaaaacaggg actttcttgt gggtggaatt ggcacaacat
    18361 gatcatttgt accttttacc agttttggca gctgtcttca ctttcttgtc cacttggttg
    18421 accaatctag cggctaaaga aaaaaatgtc atgatgactg ttatgattta tgtgatgccg
    18481 ctaatgatct ttttcatggg ctttaacttg gctagtggag tagtgctcta ttggacggtc
    18541 tcaaacgcct ttcaagtggt acaactactg ctattaaaca atccttttaa gattattgcc
    18601 gaaagacagc gtcttgccaa tgaagaaaaa gcacgccgtc ttcgtgaacg tcgtgctcgt
    18661 aaaaaagcaa tgaagagaaa ataggagttt aggttatggt attatttaca ggaaaaacag
    18721 tcgaagaggc tatcgaaaca ggacttcaag agttagggtt atcacgcctt aaagcgcata
    18781 tcaaagtcat ttcaaaagag aaaaaaggtt tcctcgggtt cggtaaaaag ccagcccaag
    18841 ttgatatcga aggtatcagc gacaagacgg tttataaggc tgataaaaaa gccactcgag
    18901 gtgttccaga ggatattaat caaaaaaatg ctcccgcggt caattctgct gatgtagaac
    18961 ctgaagaaat aaaagccact caaaagttag aagcagaaga taccaaagtg gttcctctca
    19021 tgcctgaaga aagtccagcg caaacccttt ctaatcttgc tgagacagtc actgaaacaa
    19081 aagcacaaca accgtcaatc ccagtcgagg aatcagaagt gccccaagat gctggtaatg
    19141 atggtttcag caaagatatt gaaaaagctg ctcaggaagt gtccgattat gtgactaaaa
    19201 tcatctatga aatggacatt gaagctaccg ttgaaaccag caacaatcgt cgccaaatca
    19261 atttgcaaat cgaaacgcca gaggcgggac gtgtgattgg ttaccatggt aaggtcttga
    19321 aatcattgca gttgttggcg caaaatttct tgcacgaccg ctattcaaaa aatttttcag
    19381 tatccttgaa tgtccatgat tatgtggaac atcgaacaga aaccttgatt gactttacgc
    19441 aaaaagttgc caaacgcgtc ttggaatctg gtcaagatta caccatggat cccatgagta
    19501 acagtgagcg taaaatcgtt cataaaaccg tttcatccat tgaaggggtt gatagttatt
    19561 ctgaaggcaa tgaccctaac cgctatgtgg tagtcagtct tcaacgttag atcctaaaaa
    19621 gaatctttgg tagttagttt agctatcgaa gattttttgt atggccagct taaccgtttg
    19681 ttttactgat ctcattgatc attgttgcta ttgataaggt ttcaacggta aggcaaagga
    19741 acatgtcaaa gaagagacac tttatgaaat gagcggcctc ttaaatgaga gagaaactgt
    19801 tgaaaaacga aaataaatct tgacagtaga ccctctttaa gatagaatat tatagtatgt
    19861 ttagtaactg atatcacaaa tagccggcta aacgaataca aaatctatga ggaggtattc
    19921 actgtgaaac gtacttatca accaagtaaa atccgtcgtc aacgtaaaca cggattccgt
    19981 caccgtatgt caactaaaaa cggacgtcgc gtgcttgctg cacgtcgtcg taaaggacgt
    20041 aaagtattat cagcttaatt gcaaaaaata caactaaagt aaaccaagag tgctcgaggc
    20101 tcttggtttt ttaacgtttt ctaatcggaa atttggaatg tataagtatg gtgtcaactc
    20161 cttaccttct tatttgttgt atgaaagagc attccaaata atagaaaata atataaaaaa
    20221 tgaaagtaga ttctaaaagt ctcattgcta ttgaaagcgc tttatttttt tgttataata
    20281 actttgtgaa cgttattttt attaaaacta agaaacacaa ggagtagaaa ctatgcctga
    20341 taaaccaacc aaagaaaagc tcatggagca gttaaagggt gggattatcg tttcttgtca
    20401 ggctttgcca ggtgagcctc tttattcaga gactgggggt attatgccac tgctagcaaa
    20461 agctgctcaa gaagctggtg ctgtcggcat cagagctaat tcggttaggg atattaaaga
    20521 aattcaagcc ataacagacc taccaattat cggtatcatc aaaaaagatt acccgccgca
    20581 agagcctttt attacggcaa cgatgaccga agtggatcaa ttagctgcct taaatattgc
    20641 agtgattgct atggattgta ccaagcgtga ccgacatgat ggcttggata ttgctagctt
    20701 tattcgacaa gttaaggaaa agtaccccaa tcagcttttg atggcagata ttagtacctt
    20761 tgatgaagga ctagtggccc atcaggctgg cattgatttt gttggaacca ccttgtcagg
    20821 ctacaccccg tatagtcgtc aggaagcagg tcctgatgtg gcattgatag aagctctttg
    20881 caaagcaggc attgctgtca ttgccgaagg aaagattcat tccccagaag aagccaagaa
    20941 aattaatgac ttaggtgtgg caggtattgt tgttggaggg gccatcacaa ggcctaagga
    21001 aattgcagag cgttttatcg aagcgctcaa atcctaatag tggttgtcaa actagaaaca
    21061 cacatcaaaa aaaggagatt ttacgatgaa catgaagaag ttagcttcat tagcgatgct
    21121 tggtgcatct gttttaggac tagcagcttg tggcggaaag agccagaaag aggctgatgc
    21181 aagtaaatct gatactgcta agacagaaat cacatggtgg gctttcccgg tcttcacgca
    21241 agaaaaagct gaagatggtg tgggaaccta tgagaagaaa ttgattgctg cctttgagaa
    21301 agctaatcca gaaatcaagg taaaattgga aaccattgat tttacatctg gtcctgagaa
    21361 aatcacaact gctattgaag ctggaacagc tcctgatgtc ctctttgatg ctccaggtcg
    21421 tatcattcaa tatggtaaaa atgggaaatt ggctgacttg aatgacttgt tcacagaaga
    21481 gtttaccaaa gatgttaaca atgacaaatt gattcaagcc tcaaaagcag gagatacagc
    21541 ttacatgtat cctatcagct ctgctccatt ctacatggcg ttgaataaaa aaatgctcaa
    21601 agatgctggc gtccttgacc ttgtgaaaga gggttggaca acagatgatt ttgaaaaagt
    21661 cttgaaagca ttgaaggaca aaggatataa cccaggttct ttctttgcta atggtcaagg
    21721 tggtgaccaa ggaccacgtg ccttctttgc taacctttat agtagtcata ttaccgatga
    21781 caaagtaacc aaatacacca cagatgatgc taactctatt aaagccatga ccaagatttc
    21841 caattggatt aaagatggtt taatgatgaa tggctctcag tacgatggtt cagctgatat
    21901 tcaaaacttt gcgaatggcc aaacttcctt taccattctt tgggcgcctg cacaaccagg
    21961 catccaagct aaattgttag aagctagtaa agtggattac cttgaaatcc cattcccatc
    22021 agatgatggc aaaccagaac tagaatacct cgtaaatggt tttgcggtct ttaataacaa
    22081 agatgaacaa aaagtcgctg cctctaagac atttatccaa tttatcactg atgataaaga
    22141 atggggacct aaaaatgttg ttcgtacagg tgctttccct gtaagaactt cttatgggga
    22201 tctttacaaa gacaaacgaa tggaaaaaat tgctgaatgg acaaaattct actcaccata
    22261 ctataacacg attgatgggt ttgctgaaat gagaactctt tggttcccaa tggttcaagc
    22321 cgtctctaat ggtgatgaaa agccagaaga tgctttgaaa gccttcactg aaaaagcaaa
    22381 caagacaatc aaaaaaacac aataagtgtt cctaacaagt ggcttctttt caatgcacat
    22441 gtcaaatggt cactggaaag aagcttttct ttttagaaaa gttgaacaga aaaaagaggt
    22501 atttcaagtg aacgtcaata aattaaaaat gcgagagacg ctcatctcat acgctttctt
    22561 agctccggtc ttggttttct ttgtgatttt tgtcttgata ccgatgatta tgggctttgt
    22621 gacgagcttt ttcaattatt ccatgacgga ttttaccttt gttggttttg ctaattatgc
    22681 taggatgttt caagatccca ttttcatgaa gtctcttatt aacaccttga ttattgttat
    22741 tggttcggta cctgttgtag ttttcttttc cctctttgtg gcggctaaaa cctacgacaa
    22801 aaatgtagtg gcgcgttcgt tttaccgggc agttttcttt ctgcctgttg ttaccggaag
    22861 tgttgcagtg acggtggttt ggaaatggat ctatgatccg atgtcaggga ttttgaatta
    22921 tgtcttaaaa tatgctcatg tgattgaaca aaacattagt tggctgggag ataagcactg
    22981 ggctttgtta gctattattg ttattttatt aaccacatct gttggacagc ctattattct
    23041 atatattgct gctatgggaa atattgataa ttctttgatg gaagctgcgc gtgtagacgg
    23101 cgccacagaa tttcaggtgt tttggaatat caagtggcca agtctcctgc caacaacctt
    23161 atatattgct gtcataacaa ccattaattc cttccaatgt tttgctttga ttcaactttt
    23221 gacgtctgga gggccaaatt attcaaccag taccctcatg tactatttgt atgaaaaggc
    23281 ctttaagctc tctgaatacg gctatgccaa cacaatgggt gtattcttgg cagtcatgat
    23341 tgcaatcatc agctttgctc aatttaaaat tttaggtaat gatgtggaat attaggagga
    23401 tgttaagatg acgaaaaaga aactaaccgc atcagatatc ttaaccgctg tgatgttatg
    23461 tgttttgacc attttgttta tttttccatt ttattggatt atgacaggag catttaaggc
    23521 tcaagccgat accattatga ttccaccgca atggtggcca aaggcaccta ctattgaaaa
    23581 ttttaaggcc ttggtagtgc aaaatccagc cttaaaatgg ttgtggaata gtgtctttat
    23641 ttcggtggcg accatgttct tggtttgtgg cacttcctct ttggctggct atgctttggc
    23701 caaaaagcgg ttttatggac agcggctttt gttttcgatt tttattgctg ctatggcctt
    23761 gccaaaacag gttgttctag tgcctcttgt gcggattgtt aattttatgg gaatccatga
    23821 cactttggcg gctgttattt tgcctcttgt gggctggcca tttggtgttt tccttatgaa
    23881 acagttctca gaaaatattc caaccgagtt attggaatcc gccaagattg atggatgtgg
    23941 cgaaattcgt acctttttca atgtggcttt ccctattgtc aaaccaggct ttgcagcgct
    24001 agcaattttt acctttatca atacttggaa tgattatttt atgcagttgg tgatgttaac
    24061 ctctcgggaa aatttaacga tttcacttgg ggttgccact atgcaagctg aaatggctac
    24121 taattatggc ttgattatgg caggggctgc catggctgca gtgcctattg tgacggtatt
    24181 tcttgtcttc caaaaatcat ttacccaagg cattactatg ggtgctgtga aaggttaaat
    24241 caagaaaggt ttctaacatg ttttatgatc gtttaaaaaa tattagccgt taccgaggga
    24301 ttcaccctca tttggatgcg gcgattacct ttttacaaac cacagatttg aggcaactag
    24361 ctgaagggaa atatcctatt ttaggggaga aagtatttgc agttattcaa agaaatcaat
    24421 tgagtaaagc ggacaattca ttgttggaat accacaaacg gtatgcagat tgccaccttt
    24481 tgctagctgg gaatgagtgc attcgttatg gtataggtaa tcaagctgaa gtagtgcctt
    24541 ttgaacaaga agctgatatt ggctttgtag cctgtgatcg aacctatgac ctagatttgg
    24601 ttgatgatag ctttgcttac ttttttccta atgagcctca tcaacccaat aattttaacc
    24661 aagcagggga agcagttaca aaatgcttaa tcaaagtgtt aatggcagat taggttgatt
    24721 tggcagtgaa ccaattgatg gaaaggaagt gatggtgtga cgtcgaaaaa acagggactt
    24781 ttacattctc tttttaatct tgatagtaaa tggatgaggg ctagtgcagc actatttgat
    24841 ttgctcgtgt ttaatctctt atttgtcttg tcctgccttc ctcttctgac aattggggtt
    24901 gctaaaatgg ctttttatgc gagtttgttg gattggcgag aaggtcaagt tagtcagctt
    24961 gttactactt atagatctca ttttaaatat tactttaaaa gtgggctacg ccttggcctt
    25021 attgagcttg ggataatgag tatttgtctc ttagatcttt tcttaattcg aaaccaatca
    25081 ggcctagttt ttcaagggtt taaagtactt tgcgttgctg ttttatttct ggtggttata
    25141 ctctttttgt acgcttatcc tcaggccgtc aaaagagacc tttccctatc tacgctgttt
    25201 aagcgaagct ttttactagc aggactcttt tttccatgga gttttgcttt cttgactttt
    25261 atttgtctca cgatatttag cctacaattg tctctgttaa cgttatttgg aggcgtgtct
    25321 ttgctagcta tcatcggcat cagtagccta acttacctct acttgattat catggaatct
    25381 cttcttaggc gattcccact taataatgac attgaataaa ggacattact atgacagatc
    25441 ttacgaaata ccaaggcatt attcctgcct tttacgcttg ttacgatgac caggggaata
    25501 tcagccctga gcgtgtgcgt gccttgaccc agtactatat tgacaaaggg gttcaggggc
    25561 tttacattaa tggctcttct ggagagtgta tttaccagag cgtttttgac cgtcaattgg
    25621 tgttagaaaa tgtcatggca gtcgctaagg gcaagctgac gattattaat cacgttgcct
    25681 gcaacaacac taaagatagt attgaattgg cagctcattc agaacgtttg ggcgtggatg
    25741 ccattgcagc tattccgcct atttatttcc ggttaccaga atatgcagtt gctgattatt
    25801 ggaatgcgat ttcttcggct gctcctcaca cagattttat catctataat attcctcaac
    25861 tagcaggggt tgccttgacc ccaagccttt ataagactat gttggctaat aagcgcgtga
    25921 ttggcgttaa aaattcatct atgccagtgc aggatattca aaccttctgt gcgattggtg
    25981 gggacgaccg tattgttttt aatggcccag atgaacaatt tctaggaggg cgcttgatgg
    26041 gtgctgctgc aggcattggt ggtacctacg gggctatgcc agaattattt ttaaggctga
    26101 accaacttat tgctgacaag gatttagaaa aggccaaggc ccttcaatat actattaatg
    26161 agattatcgg tgtccttgtt tctgctcacg gcaatatgta tggggttatt aaggaagtac
    26221 ttcgtattaa tgagggtctt gatattggtt ctgttcgatc acctttagct gagttggtcg
    26281 aggaagatag ggttatttgc caacgggctg ctgctctgat taatcaggct aaggaaacct
    26341 tttaataaga tgcgagggga taacaaatga agcattattt agcaattgat attggtggta
    26401 ctgctatcaa gtatggcttg atttctgaaa caggagacct gttggaaaaa gaggaaatgg
    26461 ccactgaggc ttataaaggt ggtccctcta ttttggaaaa ggtcaagggc ttggtaaaga
    26521 cctatcaaga ccaaatggat ctggctggag tggccatttc ttctgcagga atggttaatc
    26581 ctgataaggg agaaatcttt tatgccggcc ctcagattcc taactatgct ggaactcagt
    26641 ttaaaaaaga gattgaagag actttcgggt taccgtgtga agtggaaaac gatgttaact
    26701 gtgctggtct agccgaagct atttctggta gtgccaagga ttatcctgtg gctctttgct
    26761 tgacaattgg gacgggaatc ggtggctgtt tattgtttaa ttcccaagtt tttcatggta
    26821 gtagtcattc agcttgcgaa gttggttacc ttcatttgtc agatggtcag tttcaggatc
    26881 tggcatctac cacagctctt gttcaagagg tggccttagc ttatggcgat gacattagcc
    26941 aatgggatgg tcgtcgtatt tttgagcagg ctaaagcggg tgatgcgatt tgtatagcag
    27001 ccattagtaa gcaggtggat tacttaggac aaggtattgc taatatctgc tacgttgtta
    27061 acccaaatgt ggtggtgctt ggtggaggaa tcatggcgca aaaagactat ttagctgata
    27121 aattaaagac agctcttgat agctacttgg tttctagtct tgccaagaaa actcagctga
    27181 agtttgctag tcatggaaat aatgctggta tattaggagc ttactaccat tttaaacaaa
    27241 agaatgagcg atcttgttca tttataactc ttgagaaaat cgaaaataat ttagcgagta
    27301 gctaatctta gtggctgtga gtctatatga cgtgaagagt tcttgtttaa gtatactggg
    27361 ggaggtgaat gacgaccctt taaaaagaaa acaacgccct ttttgctatt gtagtctaaa
    27421 ggtcgttatt ttctttgtca ataatagtgt ttttgaagat tttttctttg tgcggtttgt
    27481 caatcgctaa aacgtaagca taaataatgt ccatcataat aagaagagga aattgtggtg
    27541 acacacgatt cccataatgt agttggtggg ttgatgatac aggaataata tctaaggagt
    27601 cgtcaaattc ggtttgatta tctgttgtta agaggacagt tttggcccct cgctgactag
    27661 cttgatgaag tgctgtgatg acagagtttg ttttgccaga taaagaaaaa ccaaaaacaa
    27721 ggcaattttc attgacgagg ctatttgccc aagtaaaacc atcagtgtct gaataagcat
    27781 cacagattaa accaagtcgc ataaagcgta gcttcatttc tcttgctact agtccagaag
    27841 atcctttgcc aaagaaatag actcgctcag aagaatcgat cagcttggct aagttcagta
    27901 atttttcctc attaacgagc tcataggttt tattaataag agcatcgtag tccatcagca
    27961 cgcgctttgt caattctaag tgaatagatt ggaaagtctc ttgtgattct tgaagactgt
    28021 gaaggtaatc aaaggcaaaa gcacgataac cagtaaaacc acattttttt gcaaatcgag
    28081 tcaaggcggc ttgagagatg tgtagtcgct taactatctc ggatgcggtc aactcttgag
    28141 gtgtcagatc ggttgtaata aaaaaatgag caatcccttt ttctaaactg gtcatatgtt
    28201 ccaatgatgc ttcgattttg gtaattaggc ggtggttttt aggcatagca aagcacactc
    28261 cttacagttt aactacctac tagtatagca tagatcgcta acagaaggta gcgacccttt
    28321 ttgtgataca gatttgttca acccacttta tttgagtagg ttgtagtatt tttgagggct
    28381 tatgtaggag ccgactatta aaggtcattt gtcaaaaaag tagaaaatag acaagtgtca
    28441 gctagcaaag ggttttacga tcaacctaaa cggcagaagt tctcaccaag ttttctgatg
    28501 tggttaagat ctttatgtta taataacatc atgacaaata aagtagaaaa actaactatt
    28561 tttgataccc atacgcacct gaatgtagca gaatttcaag gacacgaaac tgaagaattg
    28621 actttggctc aagaaatggg cgtggcctac cataatgtgg ttggctttga ccaggccact
    28681 attagtgggg cactaactct agccaataaa tatgccaata tttatgcaac tattgggtgg
    28741 catccaacag aagcaggttc ttattcagag gctgttgagg aggctatcgt ctctcaatta
    28801 tcacatccca aagtgattgc cttaggtgaa attggcttag actattattg gatggaggac
    28861 cccaaagagg tgcaaataga ggtttttaag cgccaaatgc aattagcaaa agaccatgat
    28921 ttgccttttg tggtgcacac ccgcgatgcc ttggaagata cctatgaggt catcaaagca
    28981 gctggtgttg gcccccgtgg aggcatcatg cattcttact cagggtcatt agagatggct
    29041 gaacgtttca ttgaacttgg catgatgatt tccttttcag gtgtggtcac tttcaaaaag
    29101 gctcttgata ttcaagaggc agcgcagcac ttgcctttgg ataagatttt ggtggaaaca
    29161 gatgcccctt atcttacacc agttccaaaa cgtggcaaac aaaatcatac agcttatacc
    29221 cgttatgtgg ttgataaaat cgcagagcta cgggggatga ctgtggaaga agttgcaaaa
    29281 gcaacgactg ctaatgcaaa gagggtattc aagcttgact gaaaaaatta atattcaaga
    29341 ggttcttgtt gtagaaggca aggacgacac ggctaaccta cgccgttttt acgaggtgga
    29401 tacctatgag actagaggct ctgctatcac tgaagaagat ttagaacgaa tcaatcgcct
    29461 aaacgatttg cgtggtgtta tcgttttaac agacccagat tataatggtg agcgcattcg
    29521 taagctcatt atggctgctg tgccaacagc tcgtcatgcc tttttaaacc gaaacgaggc
    29581 ggttccgagt tctaagagta agggtcgttc cttaggggtt gaacatgcca gatttgagga
    29641 tctccaaaag gcacttgctc atgtcactca gcaatatgat gatgagtctt attttgacat
    29701 tcgtcaaaca gacctgattc gtctagggct tttaatggcg tcagatagcc gtaaacgcag
    29761 ggaatacttg ggtgaaaagc tccgcatcgg ttatgccaac ggcaaacaac tgctcaagcg
    29821 cctcgaatta tttggcatta ccctagcaga agtggaagaa gtgatggaga catatgagga
    29881 gtaaagagta caataaaata taacagtccc attaactgaa tggcgtgtcc tagcaaaaaa
    29941 gtttaggcta gtggttcaaa tgccaaaaag aaagtgatca taaaaagaag agaatatatg
    30001 agaattgcag attatagcgt gaccaaggct gtccttgatc gtcacggatt tacctttaag
    30061 aaatcttttg gtcagaactt tttgaccgat accaatattt tacagaaaat cgttgacacg
    30121 gctgagattg atcagaatgt caatgttatc gagattggtc ctggaattgg ggctttgacg
    30181 gaatttttgg cagaaaatgc tgctgaagtg atggcttttg agattgatga ccgcttggtg
    30241 ccgattttgg cagatacctt gcgcgatttt gataatgtgc aagtggtcaa tcaagatatt
    30301 ttgaaagctg atttgcagac ccaaatcaag cagtttaaaa atcctgattt gcctatcaag
    30361 gtggtggcta acctacctta ctacatcaca acgcctattc tcatgcactt gattgagagc
    30421 aaaattccat tccaagagtt tgtagtcatg atgcagcgtg aagtggcaga tcgtatttct
    30481 gcggagccaa acactaaagc ttatggttcc ttgtccattg cggtacagta ttacatgact
    30541 gccaaggttg ccttcattgt gccgcgtacc gtctttgtac ctgcaccaaa tgtcgatagt
    30601 gctatcctca aaatggtgcg tcgcgaccag cctttgattg aggttgagga cgaagatttc
    30661 tttttcagag tgtctcgtct cagttttgtt catcgtcgca agaccctgtg gaataacttg
    30721 actagccatt ttggcaagtc tgaagacatc aaggctaaac ttgaaaaagg tctggcacta
    30781 gcagatatca agccttctat tcgtggtgag gccttgtcga ttcaagattt tggcaaatta
    30841 gctgatgctt taaaagaagt tggattataa aagctttccc ccggtgacaa taaaaaaatt
    30901 cccttgtaga caaaacagag atgttcagtt cagggggatt tttcttattg aagctggccg
    30961 ttaaggcatc gtagtgcaga gctagttttt ttaatacctc ggaaaaaaag gggcaattaa
    31021 caagagcgtg actatagcgg tacggttaga ctctttttcg taaatagcaa aggtcttctt
    31081 aaaattcata tcgtttccta cctcaaaaaa tcatcagtga tctgattttt agttgataaa
    31141 atattctatt tttaaaaagc agtgacctaa atgatagcca gtggtctaga gaatcttgac
    31201 agttttttaa ggcgagtgaa acttagactc aaatgctgat ttgggagcgg ttttctgata
    31261 taatagagtt attatagtag ggcaaaggag cacagttgca aggtaaaatc attaaatctc
    31321 tggctggttt ttattacgtg gagtcagaag gacaggtata tcagacgcga gcgcgtggta
    31381 attttaggaa gcgcggtgag acaccttatg ttggagatat cgtggatttc tcagcagagg
    31441 acaactctga aggttatatt ttagcgattc atcctcgtaa aaacagtttg gtaagacctc
    31501 ctatcgtcaa tattgaccaa gcagtggtta ttatgtctgc taaagaacca gaatttaaca
    31561 gcaatcttct agaccgcttt ctcatcttgc ttgaacacaa agccattcat ccagtggttt
    31621 atatctctaa gatggactta ttagatagtc ccgaggagat taaggctatt ggtcgacagt
    31681 atcaggcaat cggttacgat tttgtgacca gtcttgagga attgttgcct ttgctagctg
    31741 ataaaattac cgtctttatg ggacaaacag gtgttgggaa atcaaccctt ctcaaccgaa
    31801 tcgcccccga attggctctt gaaacaggag aaatctcaga tagtctaggg cgtggtcgtc
    31861 acaccacccg agctgtgagt ttttacaata cccatggcgg aaaaatcgcg gatacgccag
    31921 gtttctcatc attagactat gatattgcta atgctgaaga tttgaacgag gcttttccag
    31981 agctgcgccg gctgagccat gagtgtaagt ttagatcctg tacccatacc cacgaaccca
    32041 agtgtgctgt caaggcagcg cttgaaacgg gagagttgtg gccagttcgt tatgagcatt
    32101 acctgcaatt tctcagtgaa attgaaaacc gtcgtgaaac atataaaaaa gttatcaaaa
    32161 gaaagtaggt ctactccatg tcaactctaa aaattgcccc atctattcta gcagctgatt
    32221 acgctaattt tgcttctgag ctagctcgta ttgaagaaac agatgccgaa tacgttcaca
    32281 ttgacattat ggatggtcaa tttgttccta acatcagttt tggtgcagat gttgtggcaa
    32341 gtatgagaaa gcacagtaaa ttggtttttg attgtcattt aatggtggtt gatcctgaac
    32401 gctatgttga ggcttttgca caagctggtg ctgatatcat gaccattcac acagaaagta
    32461 ctcgtcatat tcatggagcc cttcaaaaaa tcaaggcagc tggcatgaaa gcaggggtag
    32521 tgattaatcc aggaactcct gcaacagccc tagaaccttt gctagactta gttgaccaag
    32581 tcctcattat gacagtcaat ccaggttttg ggggtcaggc ctttatccca gaatgtttag
    32641 aaaaagtggc taccgtagcc aaatggcgag atgaaaaagg attgtccttt gacattgagg
    32701 ttgatggcgg agtagacaat aagaccattc gtgcttgtta tgaagcaggg gccaatgtct
    32761 ttgtggcagg ttcttacctt ttcaaggcca gtgacctagt gagccaagtc caaaccttaa
    32821 ggacggcctt gaatgtctaa agttgctctt tttgcgggag gagatctctc ttatatcagc
    32881 cgtgattttg attattttgt cggtattgat agagggagcc tatttttatt agaaaatggg
    32941 cttcctttga atatggctgt tggtgatttt gattcggttc cccaaaaagc gtttacggat
    33001 ataaaagaga aggcagagct ttttattact gctcatccag aaaaaaatga tacggatacg
    33061 gaattagccc ttaaagaggt ctttgctcgt tttcctgagg cggaagtgac catttttggg
    33121 gcttttgggg gtcgaatgga ccatctctta tccaatattt ttttgcctag cgaccctggt
    33181 attgctccct ttatggcaca aatcgccttg cgtgaccaac aaaatatgct gacctaccgt
    33241 ccggcaggtc agcaccttat ccatcaagaa gaagggatga cctatgtggc atttatggca
    33301 gaaggagaag ctgacttgac cattactggt gctaaatttg agttgacgca agataatttt
    33361 ttcaaaaaga aaatctattc cagtaatgcc tttatccatc aacctattac agttagtttg
    33421 ccaagtggct acttgattat tattcaaagt aaagattgga gttagtatgg accttatctt
    33481 gttccttttg gtcttggttc tcttaggttt aggggcttat ctgttgttca aagtcaacgg
    33541 ccttcaacat cagcttgccc aaaccctaga aggcaacgcg gataatttgt ctgaccaaat
    33601 gacctaccag ttggatacag ctaacaagca acaattgtta gagctaacac agctgatgaa
    33661 ccgacaacaa gcagaccttt accaacaatt aacagatatt cgtgacgtct tgcaccgtag
    33721 tttgtctgat agtagagacc ggtctgacaa acgcttagaa gaaattaacc agcaggtcaa
    33781 ccaatcgctc aaaaatatgc aagaatctaa cgaaaaacgt ttggaggaaa tgcgccagat
    33841 cgttgaagaa aaattggagg aaaccttaaa aaatcgtctg aacgcctctt tcgattctgt
    33901 atccaagcaa ctagaaagtg tcaataaagg cttgggagaa atgcgtagcg tggctcaaga
    33961 tgtgggtact ttaaataagg ttttgtccaa taccaaaaca cgaggcattt taggcgaact
    34021 tcaactaggc caaatcattg aggatatcat gacatcaagc cagtacgaaa gagaatttgt
    34081 aacggttagt ggttctagtg aacgcgtaga atatgcgatt aagctcccag gaaatggtca
    34141 aggcggctat atttacctac cgattgactc aaaattccct cttgaagatt attaccgatt
    34201 agaagatgct tacgaagttg gtgataaact ggccatcgag gctagccgaa aagcacttct
    34261 ggcagctatc aaacgctttg ccaaagacat tcataaaaag tacttgaacc ccccagagac
    34321 gaccaatttc ggagttatgt tcttaccaac agaaggtctt tattcagaag tggtcagaaa
    34381 tgcggctttc tttgatagcc ttcgtcggga agaaaatatt gtggttgcag gtccttcgac
    34441 cctgtctgct ttgctcaatt ccttatctgt tggtttcaag acccttaata tccaaaaaaa
    34501 tgctgatgac atcagtaaaa ttttgggcaa tgtcaagtta gaattcgata aatttggcgg
    34561 cctgcttgcc aaggctcaaa agcaaatgaa tacagctaat aatacgctgg atcagctcat
    34621 ttcaacaagg acaaatgcca ttgttcgagc cttgaatacc gttgaaactt atcaagacca
    34681 agcaacaaaa tctctcttga acatgccctt attagaagag gaaaataatg aaaattaatc
    34741 aaatgaaaaa agaccagctt tttgaagggt tctacctcat taagtcggca gaggttcgta
    34801 agacaagggc tggtaaagat tttattagcc ttacctttca ggatgacact ggcgagattt
    34861 caggaaatct gtgggatgcc caaccttata acgttgaaga atttactgct ggtaaagtcg
    34921 tgtttatgaa agggcgacgc gaggtgtata atggtacccc tcaggttaat caaatcacct
    34981 tgcgaaatgt tcgcccaggg gagcccaatg atccaaagga cttcaaagaa aaggcacctg
    35041 tcagtgttga agaagtacgt gactatttgg aacagatgct ctttaaaatt gaaaatgcaa
    35101 cgtggcaacg aattgtaaga gctctttatc gtaagtatga taaagaattt tatacttatc
    35161 ctgcagctaa aacaaaccac catgcttttg agtcaggcct cgcctaccat actgctacga
    35221 tggtcagact agcagatagc attggagata tctaccctga cttaaataag agtctactgt
    35281 ttgcaggtat tatgttacat gacttagcta aagtcataga attaacagga ccagataata
    35341 cagaatacac cgttcgtggt aacttgattg ggcatatttc tctcattaac gaagaaatta
    35401 caaaagtaat ttcagaacta caaatcgatg ataccaaaga agaagtcatt gtccttaggc
    35461 acgtgatttt aagccatcac gggcaattag aatacggtag tccggtacgt ccacgcatca
    35521 tggaagctga aattattcat atgattgaca atattgatgc taatatgatg atgatgacaa
    35581 cagctcttag ccgtgttagc gagggcgaga tgaccaatcg gatttttgcc atggataatc
    35641 ggtcttttta caagccaaac tattgatcag tgtttctcaa gtaatagttc ctttgctttt
    35701 gtgatgattt ttgatgtgct taacacttat gatggtttca taagtgtttt tggctcttgt
    35761 tatggttatt aagtagaatg tcctttcagt aggaatgttg attagtttat cttagattg
//
LOCUS       DAUDWO010000020        34532 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.020, whole genome shotgun sequence.
ACCESSION   DAUDWO010000020 DAUDWO010000000
VERSION     DAUDWO010000020.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 34532)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34532)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34532
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.020"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            656..892
                     /locus_tag="VHC05_000933"
     CDS             656..892
                     /locus_tag="VHC05_000933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018364244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2829 domain-containing protein"
                     /protein_id="HEQ5402254.1"
                     /translation="MTFEEILPGLKAKKKYVRTGWGGAENYVQLFDTLEVDGKVLQAT
                     PYFLIHVTGAGEGFSMWAPTPCDVLAEDWIEVND"
     gene            885..1583
                     /locus_tag="VHC05_000934"
     CDS             885..1583
                     /locus_tag="VHC05_000934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="HEQ5402255.1"
                     /translation="MTKVVLVTGCASGIGYAQARYFLSQGYHVYGVDKSDKPDLNGNF
                     HFIKLDLSSELSPLFKVVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVK
                     LTRHYLRHMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQI
                     HIFGIAPGAVKTAMTASDFEPGGLADWVARETPIGRWTEPSEVAELTGFLASGKTRSM
                     QGEIVKIDGGWTLK"
     gene            1659..2618
                     /locus_tag="VHC05_000935"
     CDS             1659..2618
                     /locus_tag="VHC05_000935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HEQ5402256.1"
                     /translation="MKLAVLGTGMIVKEVLPVLQKIDGIDLVAILSTVRSLKTAKDLA
                     KAYKMPLATSKYEAILGNEEIDTVYIGLPNHLHFAYAKEALLAGKHVICEKPFTMTAG
                     ELDELVVIAKKRKLILLEAITNQYLSNMTFIKEHLDQLGDIKIVECNYSQYSSRYDAF
                     KRGDIAPAFNPKMGGGALRDLNIYNIHFVVGLFGRPKTVQYLANVEKGIDTSGMLVMD
                     YEQFKVVCIGAKDCTAEIKSTIQGNKGSLAVLGATNSLPQVQLSLHGHEPQVINHNKY
                     EHRMYEEFVAFKDMIDQKDFEKVNQALEHSRAVMAVLERAVHS"
     gene            2951..4288
                     /locus_tag="VHC05_000936"
     CDS             2951..4288
                     /locus_tag="VHC05_000936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEQ5402257.1"
                     /translation="MEEDYNKREPEKFTQFLRRQKVVFFVAFFGYVCAYLVRNNFKLM
                     SNTIMVQNGWDKAQIATLLSCLTVSYGLAKFYMGALGDRVSLRKLFSISLGASALICI
                     LIGFFNSSMVVLGILLVLCGVVQGALAPASQAMIANYFPNKTRGGAIAGWNISQNMGS
                     ALLPLTIALLTSMGLVVPANGNILLAFLIPGVLVFLFALCCWKLGGDNPESEGLDSLR
                     TMYGDAGESAVASEEEKHNLSYWQLIWKYVFCNPSLLLVAAVNVALYFVRFGIEDWMP
                     IYLSQVANMSEAHIHFAISILEWVAIPGSLVFAWLAVRYPNKMAKIGAIGLFVLAAIV
                     FVYERLTATGAPNYFLLLVIAGILGSLIYGPQLIVNILTINFVPLNVAGTAIGFVGVT
                     AYLIGNMGANWLMPILADGFGWFWSYIVVAALSAFSAVGYLILAKREEEIIKD"
     gene            4411..5793
                     /gene="glmU"
                     /locus_tag="VHC05_000937"
     CDS             4411..5793
                     /gene="glmU"
                     /locus_tag="VHC05_000937"
                     /EC_number="2.3.1.157"
                     /EC_number="2.7.7.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional UDP-N-acetylglucosamine
                     diphosphorylase/glucosamine-1-phosphate
                     N-acetyltransferase GlmU"
                     /protein_id="HEQ5402258.1"
                     /translation="MTNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAIN
                     PEKAVTVIGHKSEMVRAVLADQSAFVHQTEQLGTGHAVMMAETQLEGLEGHTLVIAGD
                     TPLITGESLKSLIDFHVNHKNVATILTATAQDPFGYGRIVRNKDGEVIKIVEQKDANE
                     YEQQLKEINTGTYVFDNKRLFEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILR
                     DFNESLGVNDRVALATAETVMRQRITQKHMVNGVTFQNPETVYIESDVEIAPDVLIEG
                     NVTLKGRTHIGSGTVLTNGTYIVDSEIGDNCVVTNSMIESSVLAAGVTVGPYAHLRPG
                     TTLDREVHIGNFVEVKGSHIGEKTKAGHLTYIGNAQVGSSVNVGAGTITVNYDGQNKY
                     ETVIGDHAFIGSNSTLIAPLEVGDNALTAAGSTISKTVPADSIVIGRSRQVTKEGYAK
                     RLAHHPSRSK"
     gene            5824..6378
                     /locus_tag="VHC05_000938"
     CDS             5824..6378
                     /locus_tag="VHC05_000938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEQ5402259.1"
                     /translation="MKFEEKTLKRQTVFDGHIFKVVVDDVELPNNLGQSKRELIFHRG
                     AVAVLAITPERKIVLVKQYRKAIESVSYEIPAGKLEIGEEGSKLKAAARELEEETAYT
                     GTLTFLYEFYTAIGFCNEKITLFLATDLTQVANPKPQDDDEVIEVLELTYQECMDLVA
                     QGKLADAKTLIALQYYALHFGGEQ"
     gene            6378..6629
                     /locus_tag="VHC05_000939"
     CDS             6378..6629
                     /locus_tag="VHC05_000939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402260.1"
                     /translation="MGRPLLTDDIIEKARRMETFEPDDAVDFDTKVMTLPEKDEKARI
                     YKSRRIENAKRSQLQSKLNVILIAVMLLIAILVYAIFYL"
     gene            6649..7344
                     /locus_tag="VHC05_000940"
     CDS             6649..7344
                     /locus_tag="VHC05_000940"
                     /EC_number="3.2.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/adenosylhomocysteine
                     nucleosidase"
                     /protein_id="HEQ5402261.1"
                     /translation="MKIGIIAAMEEELSLLLANLLDAQEHQVLSKTYYTGRFGKHELV
                     LVQSGVGKVMSAMTVAILVEHFKAQAIINTGSAGAVASHLAIGDVVVADRLVYHDVDV
                     TAFGYAYGQMAGQPLYYDCDPQFVAIFKQVLKHEKTNGQVGLIATGDSFVAGQNKIDQ
                     IKTAFSDVLAVEMEGAAIAQAAHTAGKPFIVVRAMSDTAAHDANITFDQFIIEAGKRS
                     AQILMTFLENLPV"
     gene            7495..7836
                     /locus_tag="VHC05_000941"
     CDS             7495..7836
                     /locus_tag="VHC05_000941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402262.1"
                     /translation="MTIKKHYYLLSLLALVTVGAAFNTSQSVSAQVYSNGGYRQGLTD
                     EKSHLQYSKDNAQLQLRNILNGYQDDLGRNYSSYYYYNLRTVMGLSKEQKIEEHYEKL
                     KDELYRMYNHY"
     gene            complement(7933..8580)
                     /locus_tag="VHC05_000942"
     CDS             complement(7933..8580)
                     /locus_tag="VHC05_000942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent transcriptional regulator"
                     /protein_id="HEQ5402263.1"
                     /translation="MTPNKEDYLKCIYEIGEQEPKITNKMVAEKMHVSAPAVSEMIKK
                     MISQGWIVKDKAKGYLLKDKGYALVANLYRKHRLIEVFLIHQLGYNTQEVHQEAEVLE
                     HTVSDTFIDRLDKILDFPDFCPHGGTIPRYGQPLVEMNTTTLNTITELGRFRLSRIHD
                     HFDLIQYLETHHLNINTELTLTQIDTFAKTYTICYGDKELVIPENIAKQLYVTAL"
     gene            8726..9658
                     /locus_tag="VHC05_000943"
     CDS             8726..9658
                     /locus_tag="VHC05_000943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_101244918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter substrate-binding protein"
                     /protein_id="HEQ5402264.1"
                     /translation="MGKRMSLILGAFLSVFLLVACSSTGTKTAKSDKLKVVATNSIIA
                     DMTKAIAGDKIDLHSIVPIGQDPHEYEPLPEDVEKTSNADVIFYNGINLEDGGQAWFT
                     KLVKNAQKTKNKDYFAVSDGIDVIYLEGASEKGKEDPHAWLNLENGIIYSKNIAKQLI
                     AKDPKNKETYEKNLKAYVAKLEKLDKEAKSKFDAIAENKKLIVTSEGCFKYFSKAYGV
                     PSAYIWEINTEEEGTPDQISSLIEKLKVIKPSALFVESSVDRRPMETVSKDSGIPIYS
                     EIFTDSIAKKGKPGDSYYAMMKWNLDKISEGLAK"
     gene            9722..10447
                     /locus_tag="VHC05_000944"
     CDS             9722..10447
                     /locus_tag="VHC05_000944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004218966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402265.1"
                     /translation="MITTNNLCVTYDGNSNALEAINVTIDGPSIVGIIGPNGAGKSTF
                     MKAILNLIDYQGHVTVDGKDGRKLGHTVAYVEQRSMIDYNFPITVKECVALGTYSKLG
                     LFRRVGKKQFEQVDKVLKQVGLEDFGHRPIKSLSGGQFQRMLVARCLIQESDYIFLDE
                     PFVGIDSVSEKIIVDLLKELKMAGKTILIVHHDLSKVEHYFDKLMILNKHLVAYGNVC
                     EVFTVDTLSKAYGNHLILGKEMV"
     gene            10448..11302
                     /locus_tag="VHC05_000945"
     CDS             10448..11302
                     /locus_tag="VHC05_000945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HEQ5402266.1"
                     /translation="MSMKFFEGLMSYHFLQNALITAVVIGIVSGAVGCFIILRSMSLM
                     GDAISHAVLPGVALSFILGVNFFIGAIIFGLLASVIITYIKENSVIKGDTAIGITFSS
                     FLALGVILIGVANSSTDLFHILFGNILAVQDSDKWITIGVSIFVLGVISLFFKELLLT
                     SFDPILAKSMGVKVNAYHYLLMVLLTLVAVTAMQSVGTILIVALLITPAATAYLYANS
                     LKVMLVMSSLLGALASVLGLYLGYTFNVAAGSSIVLTSAMMFLISFFVSPKQGYLKRW
                     MQKKEKTP"
     gene            complement(11450..12256)
                     /locus_tag="VHC05_000946"
     CDS             complement(11450..12256)
                     /locus_tag="VHC05_000946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HEQ5402267.1"
                     /translation="MKKLLSLSLVAISLLSLSACESVDRAIKGDKYIDEKTAKEESEA
                     ASKAYEESIQKALKADASQFPQLTKEVGKEEAKVVMRTSQGDITLKLFPKYAPLAVEN
                     FLTHAKKGYYDNLTFHRVINDFMIQSGDPKGDGTGGESIWKGKDPKKDAGNGFVNEIS
                     PFLYHIRGALAMANAGANTNGSQFYINQNKKNQSKGLSSTNYPKPIISAYEHGGNPSL
                     DGGYTVFGQVIDGMDVVDKIAATSINQNDKPEQDITITSIDIVKDYRFKN"
     gene            12473..14878
                     /locus_tag="VHC05_000947"
     CDS             12473..14878
                     /locus_tag="VHC05_000947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HEQ5402268.1"
                     /translation="MVKRNQRRKSAPKKRLTKAEVEKQRAIKRMILSVLMALLLIFAM
                     LRLGVFGVTTYNMIRFLVGSLAYPFMFAWLIYLFCFKWLRQKDGMIAGVVIAFLGLLV
                     EWHAFLFAMPRMLDQDIFLGTARLITRDLLALRVTEFVGGGMLGALLYKPIAFLFSNI
                     GSYFIGFLFILLGLFLMTPWDIYDVSHLVKEAVDKLAVAYQENKEKRFIKREEHRLQA
                     EKEALEKQAQEEEKRLAELTVDPETGEIVEDSQSQVSYDLAEDMTKEPEILAYDSHLK
                     DDEASLFDQEDLAYAHEEIGAYDSLSALASSEDEMDMDEPVEVDFTPKTHLLYKLPTI
                     DLFAPDKPKNQSKEKNLVRKNIKVLEDTFQSFGIDVKVERAEIGPSVTKYEIKPAVGV
                     RVNRISNLADDLALALAAKDVRIEAPIPGKSLIGIEVPNSEIATVSFRELWEQSDANP
                     ENLLEVPLGKAVNGNARSFNLARMPHLLVAGSTGSGKSVAVNGIISSILMKARPDQVK
                     FMMIDPKMVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYELFSKIGVRNIA
                     GYNTKVEEFNASSEQKQIPLPLIVVIVDELADLMMVASKEVEDAIIRLGQKARAAGIH
                     MILATQRPSVDVISGLIKANVPSRMAFAVSSGTDSRTILDENGAEKLLGRGDMLFKPI
                     DENHPVRLQGSFISDDDVERIVNFIKDQAEADYDDAFDPGEVSDNDPGFSGNGGAAEG
                     DPLFEEAKALVLETQKASASMIQRRLSVGFNRATRLMDELEEAGVIGPAEGTKPRKVL
                     QTN"
     gene            complement(14948..15301)
                     /locus_tag="VHC05_000948"
     CDS             complement(14948..15301)
                     /locus_tag="VHC05_000948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3397 domain-containing protein"
                     /protein_id="HEQ5402269.1"
                     /translation="MMIYKLTALAFLIVTPLFAMIVTSLFKLNKKGFNFPDVALLLFA
                     IEIVLVSGKFFTHNLLPYYLIIMSLLAIVISLLLVIRTQSFSYHRFMKLFWRVGFLVT
                     VIFYLILVIFIFTLA"
     gene            15545..15970
                     /gene="rplK"
                     /locus_tag="VHC05_000949"
     CDS             15545..15970
                     /gene="rplK"
                     /locus_tag="VHC05_000949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004226069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11"
                     /protein_id="HEQ5402270.1"
                     /translation="MAKKVEKLVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNA
                     RTADQAGMIIPVVISVYEDKSFDFITKTPPAAVLLKKAAGVEKGSGTPNTTKVATVTR
                     AQVQEIAETKMPDLNAANIEAAMRMIEGTARSMGFTVTD"
     gene            16076..16765
                     /gene="rplA"
                     /locus_tag="VHC05_000950"
     CDS             16076..16765
                     /gene="rplA"
                     /locus_tag="VHC05_000950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004194879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L1"
                     /protein_id="HEQ5402271.1"
                     /translation="MAKKSKQMRAALEKVDSTKAYSVEEAVALVKETNFAKFDASVEV
                     AYNLNIDVRKADQQIRGAMVLPNGTGKTQRVLVFARGAKAEEAKAAGADFVGEDDLVA
                     KINGGWLDFDVVIATPDMMAIVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGK
                     ITYRADKAGNVQALIGKVSFDADKLVENFKAFHDVMAKAKPATAKGTYMANVSITSTQ
                     GVGIKVDPNSL"
     gene            17087..17815
                     /locus_tag="VHC05_000951"
     CDS             17087..17815
                     /locus_tag="VHC05_000951"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HEQ5402272.1"
                     /translation="MEPKYQRILIKLSGEALAGEKGVGIDIPTVQAIAKEIAEVHVSG
                     VQIALVIGGGNLWRGEPAADAGMDRVQADYTGMLGTVMNALVMADSLQHYGVDTRVQT
                     AIPMQNVAEPYIRGRALRHLEKNRIVVFGAGIGSPYFSTDTTAALRAAEIEADAILMA
                     KNGVDGVYNADPKKDANAVKFDELTHGEVIKRGLKIMDATASTLSMDNDIDLVVFNMN
                     EAGNIQRVVFGEHIGTTVSNKVCD"
     gene            17844..18401
                     /gene="frr"
                     /locus_tag="VHC05_000952"
     CDS             17844..18401
                     /gene="frr"
                     /locus_tag="VHC05_000952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome recycling factor"
                     /protein_id="HEQ5402273.1"
                     /translation="MANAIIETAKERFAQSHQSLSREYASIRAGRANASLLDRIQVDY
                     YGAPTPLNQLASITVPEARVLLISPFDKSSIKDIERALNASDLGITPANDGSVIRLVI
                     PALTEETRKELAKEVKKVGENAKIAIRNIRRDAMDDAKKQEKAKEITEDELKTLEKDI
                     QKATDDAIKEIDRMTAEKEKELLSV"
     gene            18510..19367
                     /locus_tag="VHC05_000953"
     CDS             18510..19367
                     /locus_tag="VHC05_000953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HEQ5402274.1"
                     /translation="MNDLLATVITGLIKEENANDYFIQKEGFTFTLSKAEGERQVGDM
                     VTGFAYIDIKQKARLTTKEIRSTRTSYGWGEVTEIRRDLGVFVDTGIPNKEIVVSLDV
                     LPEMKELWPKKGDKLYIRLDVDKKDRIWGLPAEPEVFQKMASPAYNNMQNQHWPAIVY
                     RLKLTGTFVYLPENNMLGFIHPSERYAEPRLGQVLDARVIGFREVDRTLNLSLKPRSF
                     EMLENDAQMIVTYLEANGGFMTLNDKSSPEEIKAIFGISKGQFKKALGGLMKAKRIKQ
                     DATGTELIG"
     gene            19440..19949
                     /gene="msrA"
                     /locus_tag="VHC05_000954"
     CDS             19440..19949
                     /gene="msrA"
                     /locus_tag="VHC05_000954"
                     /EC_number="1.8.4.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /protein_id="HEQ5402275.1"
                     /translation="MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQV
                     CAKTTGHTEAVEIIFDPEEISYKELVELYWAQTDPTDAFGQFEDRGDNYRPVIYYTTE
                     RQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIR
                     HQFLEENWS"
     gene            19946..20161
                     /locus_tag="VHC05_000955"
     CDS             19946..20161
                     /locus_tag="VHC05_000955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YozE family protein"
                     /protein_id="HEQ5402276.1"
                     /translation="MRKSFYSWLMTQRNPKSNEPVAILADLVFDDTTFPKHTNDFELI
                     SRYLEDQASFSFNLGQFDEIWEDYLAH"
     gene            20317..21498
                     /locus_tag="VHC05_000956"
     CDS             20317..21498
                     /locus_tag="VHC05_000956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HEQ5402277.1"
                     /translation="MIITKKSLFVTSVALSLAPLATAQAQEWTPRSVTEIKSELVLVD
                     NVFTYTVKYGDTLSTIAEAMGIDVHVLGDINHIANIDLIFPDTILTANYNQHGQATTL
                     TVQAPASSPASVSHVPSSEPLPQASATSQSTVPMAPSATPSDVPTTPFASAKPDSSVT
                     ASSELTSSTNDVSTELSSESQKQPEVPQEAVPTPKAAETTEVEPKTDISEDSTSANRP
                     VPNESASEEVSSAAPAQAPAEKEETSQMLTAPAAQKAVADTTSVATSNGLSYAPNHAY
                     NPMNAGLQPQTAAFKEEVASAFGITSFSGYRPGDPGDHGKGLAIDFMVPENSALGDQV
                     AQYAIDHMAERGISYVIWKQRFYAPFASIYGPAYTWNPMPDRGSITENHYDHVHVSFN
                     A"
     gene            21814..23586
                     /locus_tag="VHC05_000957"
     CDS             21814..23586
                     /locus_tag="VHC05_000957"
                     /EC_number="4.2.1.53"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oleate hydratase"
                     /protein_id="HEQ5402278.1"
                     /translation="MYYTSGNYEAFATPRKPEGVDQKSAYIVGTGLAGLAAAVFLIRD
                     GHMAGERIRLFEELPLAGGSLDGIEKPHLGFVTRGGREMENHFECMWDMYRSIPSLEI
                     PGASYLDEFYWLDKDDPNSSNCRLIHKRGNRVDDDGQYTLGKQSKELIHLIMKTEESL
                     GDQTIEEFFSEDFFKSNFWIYWATMFAFEKWHSAVEMRRYAMRFIHHIDGLPDFTSLK
                     FNKYNQYDSMVKPIIAYLESHDVDIQFDTKVTDIQVEQTAGKKVAKTIHMTVSGEAKA
                     IELTPDDLVFVTNGSITESSTYGSHHEVAKPTKALGGSWNLWENLAAQSDDFGHPKVF
                     YQDLPAESWFVSATATIKHPAIEPYIERLTHRDLHDGKVNTGGIITITDSNWMMSFAI
                     HRQPHFKEQKDNETTVWIYGLYSNSEGNYVHKKIEECTGQEITEEWLYHLGVPVDKIK
                     DLASQDYINTVPVYMPYITSYFMPRVKGDRPKVIPDGSVNLAFIGNFAESPSRDTVFT
                     TEYSIRTAMEAVYSFLNVERGIPEVFNSAYDIRELLKAFYYLNDKKAIKDMDLPIPAL
                     IEKIGHKKIKDTFIEELLKDANLM"
     gene            23745..24797
                     /locus_tag="VHC05_000958"
     CDS             23745..24797
                     /locus_tag="VHC05_000958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HEQ5402279.1"
                     /translation="MQEYSIDITLTHPDDVLALFGSNERHLKLIEAHLGVIVHARTER
                     VQVIGDDEEAVELARLTIKALLVLVGRGMVVNTSDVVTALSMAESHQIDQFMALYEEE
                     IIKDNYGKAIRVKTLGQKTYVDSVKRHDVVFGVGPAGTGKTFLAVTLAVTALKRGQVK
                     RIILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYHILGKEQTTRLMERDVIEIA
                     PLAYMRGRTLDDAFVILDEAQNTTIMQMKMFLTRLGFNSKMIVNGDTSQIDLPRNVKS
                     GLIDATQKLQGIKQIDFVYFSAKDVVRHPVVADIIKAYETSSEEMKDLLKPKASDVEA
                     DYQPGLTKYPVIGQEH"
     gene            24843..25418
                     /locus_tag="VHC05_000959"
     CDS             24843..25418
                     /locus_tag="VHC05_000959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HEQ5402280.1"
                     /translation="MDDLTKAIMADEANLSYTERGIFPLYDAPQTARIIIVGQAPGIV
                     AQETKLYWNDRSGIRLRDWLGVDNDTFYHSGLFGIIPMDFYYPGKGKSGDLPPREGFA
                     AKWHPPLRALMPEVELTILVGRYAQDFYLGNKAYKTLTETVRHFEDYLPDYFPLVHPS
                     PRNQLWLAKNPWFEQDLLPILQKRVEAILTK"
     gene            25577..26074
                     /gene="ybeY"
                     /locus_tag="VHC05_000960"
     CDS             25577..26074
                     /gene="ybeY"
                     /locus_tag="VHC05_000960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007895872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="HEQ5402281.1"
                     /translation="MYIEMIDETGQVSQEIMEQTLDLLNFAAQKTGKEEKEMSVTFVT
                     NERSHELNLEYRDTDRPTDVISLEYKPETPILFSQEDLAADPSLAEMMAEFDAYIGEL
                     FISIDKAREQSQEYGHSFEREMGFLAVHGFLHINGYDHYTLEEEKEMFTLQEEILTAY
                     GLTRQ"
     gene            26055..26462
                     /locus_tag="VHC05_000961"
     CDS             26055..26462
                     /locus_tag="VHC05_000961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase"
                     /protein_id="HEQ5402282.1"
                     /translation="MALHDNNTTKRKWKNRTITSSLEFALTGVFTAFKEERNLRSHLL
                     SACLACVAGLFFSISAIEWLFLLLAIFLVITLEIVNSAIENVVDLASDYHFSMLAKNA
                     KDMAAGAVLMISGYAVLTGLIIFIPKIWNIFVH"
     gene            26582..27478
                     /gene="era"
                     /locus_tag="VHC05_000962"
     CDS             26582..27478
                     /gene="era"
                     /locus_tag="VHC05_000962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase Era"
                     /protein_id="HEQ5402283.1"
                     /translation="MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIM
                     GIYTTETEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDD
                     MIIERLKAAKIPVILVINKIDKVHPDQLLAQIDDFRSQMEFKEVVPISALEGNNVPTL
                     IKLLTDNLEEGFQYFPEDQITDHPERFLVSEMIREKVLHLTQQEVPHSVAVVVESMKR
                     DEETDKVHIRATIMVERDSQKGIIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVK
                     VKKNWRDKKLDLADFGYNEKEY"
     gene            27498..27974
                     /locus_tag="VHC05_000963"
     CDS             27498..27974
                     /locus_tag="VHC05_000963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX domain-containing protein"
                     /protein_id="HEQ5402284.1"
                     /translation="MPQDYISYIRSKVGHDKIILNFAGGILTDDDGKVLMQLRGDKKT
                     WAIPGGTMELGESSLETCKREFLEETGIEVEAVRLLNVYTHFEEVYPNGDAVQTIVFI
                     YELTAVSDMAIDNFHNEETLKLQFFSHEEIAELESVSAKHRLMLEEYFSDSFAMGH"
     gene            28679..29077
                     /locus_tag="VHC05_000964"
                     /pseudo
     CDS             28679..29077
                     /locus_tag="VHC05_000964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061151.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family transcriptional regulator
                     DNA-binding domain-containing protein"
     gene            complement(29135..29581)
                     /locus_tag="VHC05_000965"
     CDS             complement(29135..29581)
                     /locus_tag="VHC05_000965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEQ5402285.1"
                     /translation="MSYKYGFGRDTLSDISLTIKEGEKVSIVGISGSGKTILAKMIVN
                     FFEPYKGQISINHQNLKMIDKKVLRQHINYLPQQAHIFSGSILENLTLGANHSTSQED
                     ILINIRNDIHILKFDTYFQTGQNIKKEKRIKRKIFHSYFIYIYFSM"
     gene            complement(29804..30514)
                     /locus_tag="VHC05_000966"
     CDS             complement(29804..30514)
                     /locus_tag="VHC05_000966"
                     /inference="COORDINATES: protein motif:HMM:NF012869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402286.1"
                     /translation="MSFLPLIFKQESLIFYIVLASLLVTLINIGGSYYLQGIWDEYIP
                     NQMKPTLGIISIGLIVTYILQQMMSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSF
                     FVTRRTGEIISRFTDANAIIDTLASTILSLFLDVSILSIVGGVLLVQNTNLFLLSLIS
                     IPIYIIIIFTFMKPFEKMNNNVMQSNSMASSAIIEDINGIETIKSLTSEEIRYQKIDS
                     EFVDYLDKSFKLSKYSTK"
     gene            complement(30619..30855)
                     /locus_tag="VHC05_000967"
     CDS             complement(30619..30855)
                     /locus_tag="VHC05_000967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402287.1"
                     /translation="MTSCKRTFVPQIDARDCGIAALASIAKFYGSDYSLTHLRELAKT
                     NKEGTTTLGIVKAAKEMGFEKNISSLEIQIPPLK"
     gene            31153..31377
                     /locus_tag="VHC05_000968"
     CDS             31153..31377
                     /locus_tag="VHC05_000968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Blp family class II bacteriocin"
                     /protein_id="HEQ5402288.1"
                     /translation="MNTTIKQFEIMDEAMLTGIEGGCSWHGLAQAAVFTGAGNGFRLG
                     VKTRTWQGAAAGAAGGLVIGGVGYGATCWW"
     gene            31355..31531
                     /locus_tag="VHC05_000969"
     CDS             31355..31531
                     /locus_tag="VHC05_000969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402289.1"
                     /translation="MGRLVGGNNHGYQKFFAWFSYWFTLPNFRQYIIEYPEKLEKPIE
                     DTKMGLYSVYIGDL"
     gene            31888..32136
                     /locus_tag="VHC05_000970"
     CDS             31888..32136
                     /locus_tag="VHC05_000970"
                     /inference="COORDINATES: protein motif:HMM:NF014566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEQ5402290.1"
                     /translation="MEEILFRGILQEKLSRVSFWLSIIVTSVIFSYIHGNDTILNTQF
                     ISSLIYGMAYQTSKDLRFPIINHSLQNLIVLLTVVLLK"
     gene            32747..32974
                     /locus_tag="VHC05_000971"
     CDS             32747..32974
                     /locus_tag="VHC05_000971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Blp family class II bacteriocin"
                     /protein_id="HEQ5402291.1"
                     /translation="MNTKTMEQFEVMNSEMLAGVEGGWGGWGEAIAGLLGGFAPSPTL
                     DQLNGKWPIRKPSKPCSPYGTGGTPNTCNGL"
     gene            33023..33340
                     /locus_tag="VHC05_000972"
     CDS             33023..33340
                     /locus_tag="VHC05_000972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="role in replication"
                     /protein_id="HEQ5402292.1"
                     /translation="MLTLYKRQIAEVWEIGRETPQPEWVRDAFRKNYICWLDEHVRIL
                     MTGLNPSLTTNLKISATGTVGGGFAGYGMYVLGYPGDFLDVTNHRVISAKKFHKEYQI
                     IDG"
     gene            33406..33687
                     /locus_tag="VHC05_000973"
     CDS             33406..33687
                     /locus_tag="VHC05_000973"
                     /inference="COORDINATES: protein motif:HMM:NF013677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEQ5402293.1"
                     /translation="MEDCRKYFLCRFSFIHHLFGTKIISSTLKIHPNSLYRWIQEYEK
                     YGESAFPGHGSALRHAQFETKKLEKEHKLLQEELALLKKFQVFLKPNWK"
     gene            33720..34016
                     /locus_tag="VHC05_000974"
     CDS             33720..34016
                     /locus_tag="VHC05_000974"
                     /inference="COORDINATES: protein motif:HMM:NF024673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEQ5402294.1"
                     /translation="MNSHHACQTLQVSRSGFYAYLKRRPSSRHVENEALKEMIKAIFY
                     EHKERYGSVRITQELCRRGIHVNHKRVGRLLHQLGLYAKGSRYQYKYYNRRRSS"
     gene            34023..34433
                     /locus_tag="VHC05_000975"
                     /pseudo
     CDS             34023..34433
                     /locus_tag="VHC05_000975"
                     /inference="COORDINATES: protein motif:HMM:NF033516.0"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            34446..>34532
                     /locus_tag="VHC05_000976"
     CDS             34446..>34532
                     /locus_tag="VHC05_000976"
                     /inference="COORDINATES: protein motif:HMM:NF024729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402295.1"
                     /translation="MFKYSETYYNPKRLHSALGYLSPVEFEKI"
BASE COUNT        10727 a         5940 c         7403 g        10462 t
ORIGIN      
        1 ttaagtgttt tatagaattc cagaaagatt ttatagaatt attattacgg tttttcgatt
       61 ttggaaaata aaaggtacct tcaaggtgac ttttattatt taagtggctt aatgaattgg
      121 ttaaaatctt tttagtttag taaaattgct atttaaggtt agccacctct cgtatagtca
      181 cagttgatga attatgctat agtatagaca taaaaaagag ttcaaatccc ttcttgcctg
      241 ttggtggatt ttgaactgaa agcctctctg attgcagttg gtaggctttt ttgatgcttt
      301 ttcgtacttt ttttatttat tacgctaaaa aatgttatac ttaatgaaga aaaaggagag
      361 tttagaacgt taagatacct cacagcagat tgatagagga tatggaagaa ggttagcttt
      421 cccaagagat gccgtttggg aatggtataa caataactgg gagaagttat aagtaaaaca
      481 agaacaaatt aactcagatg atttttagac gtttccacgc gcgtgcgaat tgatgttatc
      541 aataaatcct ctaataacgc ctttttcgaa caggaaacaa atttattatc ccacgcgtgt
      601 gcgaattaat tggagaaaaa atgagaaaat acgatataca aaaaaggaga acaatatgac
      661 atttgaagaa attctaccag gtttaaaagc caaaaaaaaa tatgtacgta caggttgggg
      721 tggcgctgaa aattatgtgc agttgtttga tacccttgaa gtggatggga aagtactaca
      781 ggcgacacct tattttctga ttcatgttac tggtgcaggt gaaggttttt ccatgtgggc
      841 accgacacca tgtgatgtgt tagcagaaga ttggatcgag gtcaatgact aaagttgttt
      901 tagtgacggg ctgtgctagt gggattggtt atgcacaggc ccgctatttt ttgagccaag
      961 ggtatcacgt atatggtgtg gataaatcgg ataaaccgga cttaaacggt aattttcact
     1021 ttatcaaatt ggatttatcc tctgagttat ccccactatt taaagtggtc cccagtgttg
     1081 atattttgtg taatactgcg gggattttag atgcctacaa accactttta gacgtcagtg
     1141 atgaagaagt ggaacaccta tttgatatta atttttttgc gacggtgaag ttaacacgtc
     1201 attatcttag acatatggtg gaaaagcagt caggtgttat catcaatatg tgctcaatag
     1261 caagttttat agcaggtggc ggtggtgttg cctatacgag ttctaagcat gcgcttgcgg
     1321 gcttcacgcg ccagctggct ttggattacg ccaaagatca gattcacatc tttggtatag
     1381 caccaggtgc tgtcaaaacc gctatgacgg ctagcgactt tgagcctggt ggcttagcag
     1441 actgggtagc tcgtgagacg ccaattgggc gttggactga accaagtgaa gttgctgaat
     1501 taacgggatt tcttgcttca ggaaaaacga gatcaatgca aggtgaaatt gtcaaaattg
     1561 acggtggttg gactttgaaa tgatcacatg ccttagcttg agctggcgca gtaagcccta
     1621 gaggtgtgat gagtcaaaca gtcaaaggag atgaacaaat gaaattagcg gttttgggga
     1681 caggtatgat tgttaaggaa gttttgcctg tcttgcagaa aattgatggt attgatttag
     1741 ttgctatctt atcaacagtt agaagtttaa agacagctaa agaccttgct aaggcatata
     1801 agatgcctct agctacgagt aaatatgagg ctatcttagg caatgaggag attgacacag
     1861 tttatattgg attgccaaat cacttgcatt ttgcctatgc taaggaggct cttctggctg
     1921 gtaaacatgt catttgtgaa aagcccttta ccatgacagc aggagaatta gatgaactgg
     1981 tggtgatcgc taaaaaacga aaactcattt tgttagaagc gattaccaat cagtatttaa
     2041 gcaacatgac ctttatcaaa gagcatcttg accaacttgg cgatatcaaa attgtagaat
     2101 gtaactattc acaatattct tcacgctacg atgccttcaa acgaggtgat atcgcgccag
     2161 cttttaatcc taaaatgggt ggtggagctt tacgtgattt aaacatttac aacattcatt
     2221 ttgtggtagg gttatttggt cgccctaaaa cggttcaata tttagccaat gtcgaaaaag
     2281 gcattgacac atcaggcatg cttgtcatgg actatgagca gtttaaagtg gtatgtatcg
     2341 gggccaaaga ctgcactgca gaaatcaaat caaccatcca aggtaataaa gggtcactgg
     2401 cagtgcttgg agcaacaaat agccttcctc aggttcagtt aagtctacac ggtcacgaac
     2461 cacaagtgat taaccacaac aagtatgagc accggatgta tgaggagttt gtcgctttta
     2521 aagacatgat tgaccaaaaa gactttgaga aagtgaatca ggctttggag catagccgag
     2581 ctgtcatggc tgtgttggag cgagctgttc attcgtgatg gtaatctggt agccattgcc
     2641 ttttgtgcag gtgctatggt aatggttgaa agacgtgttt tcacgagggt taaccccttc
     2701 gtgctttttt ggcaaaaata acttgttcag gatttgggct ttctttgtga gatgagagat
     2761 gcctgacgaa ttgatttgat taaattaatg ataaagccaa acgatttaag aaatgaccgt
     2821 tcggaaattc tgccccaaag ggtctctaga agcagtgaaa tcgaatttgt aagcgttgac
     2881 actgctacat aactctgtta cactaagaga atgtcatgac aaaaattaca gtgtaggagt
     2941 ttaattgttt atggaagagg attataacaa aagagaacct gagaagttta cgcaatttct
     3001 gcgccgtcaa aaggtcgtct tttttgtcgc attttttggt tatgtgtgtg cctacttggt
     3061 acgcaacaat ttcaaactaa tgtcaaacac tattatggtc caaaacggtt gggacaaggc
     3121 tcaaattgcg accttgttat cgtgtttgac cgtttcttat ggtttagcaa aattctatat
     3181 gggggcctta ggggatcgtg ttagcttgag gaagctcttt tcaatcagct tgggtgcaag
     3241 cgctttgatt tgtattttaa tcggtttttt caatagttca atggtggtgt tagggatact
     3301 gctagtcttg tgtggtgtcg tacaaggtgc cttggcacct gcctcacaag ccatgattgc
     3361 caattatttt ccaaataaaa cacgcggcgg agccatcgct ggatggaaca tttctcaaaa
     3421 catgggatca gccctcttgc cattaaccat cgccttgctc accagtatgg gcttggtggt
     3481 accagctaat ggcaatattt tacttgcctt tttaatccct ggtgttttag tgttcttgtt
     3541 tgctttgtgt tgctggaagc ttggcggtga taaccctgag tctgagggac ttgactctct
     3601 tcgaacgatg tatggtgatg cgggcgaatc agctgttgcc agtgaagaag aaaagcataa
     3661 cctgtcttat tggcaactca tctggaaata cgttttttgt aacccgtcac tcttacttgt
     3721 tgctgctgtc aatgtggccc tttattttgt tcgttttggg attgaagact ggatgccgat
     3781 ctacttgtca caagtagcca atatgtcaga ggcccatatt cattttgcga tttcaatatt
     3841 agagtgggtc gctattccag gctcgctggt atttgcgtgg ttagcggttc gttatcctaa
     3901 taaaatggcc aagattgggg ctattgggct ttttgtgtta gcggctattg tgtttgtcta
     3961 tgaacgcttg actgccacag gtgctccaaa ctatttcttg ttgcttgtta ttgcaggtat
     4021 tttagggtca ttgatttatg gcccacagtt gatcgtgaat attttaacaa tcaactttgt
     4081 tcctttaaat gttgcaggaa cagcgattgg ttttgtagga gtaacagctt atctcatcgg
     4141 caatatggga gcaaactggc tgatgccgat tttggcagat ggttttggct ggttttggtc
     4201 atatattgtc gttgcagcct tatctgcttt ttcagcggtt ggttatttga ttttagccaa
     4261 acgtgaggaa gaaatcatca aagattagct aggcatcaca agccgcaagt gacactataa
     4321 aagacaagaa aatgctagga tgtttcagga aaaaaagaga aaatatgcta taatgagaag
     4381 gtatttaaat tatatagtaa ggaagaacaa atgacaaatt atgccattat tttagcagcg
     4441 ggcaaaggga ctcgcatgac ttctgatctc ccaaaagttc ttcataaagt atctggacta
     4501 accatgcttg agcatgtttt tcgtagtgta aaagcgatta atcctgaaaa agccgtgacg
     4561 gttattggtc acaaatcaga aatggtacgt gctgtcttag cagatcaatc agcctttgtc
     4621 catcaaacag agcagttagg aactggccat gccgtgatga tggcagaaac acaactagaa
     4681 ggactagaag ggcatacctt ggtgattgca ggagatactc ccttgatcac tggagaaagc
     4741 ctgaagagtc tgattgattt tcatgtgaat cataaaaatg tcgccactat tttaacagct
     4801 acggctcaag atccatttgg ttatggtcgt attgttcgca acaaagatgg cgaagtgatc
     4861 aagattgttg agcaaaaaga cgccaatgag tatgagcaac aattaaaaga aatcaataca
     4921 ggaacctatg tgtttgataa caagcgtctc tttgaagcgc tcaaatgcat cactaccaac
     4981 aatgctcaag gagagtatta cctgactgat gttgtggcta tttttagagc aaacaaagaa
     5041 aaggtaggag cctatatcct gagagacttc aatgaaagtc ttggtgttaa tgatcgtgtg
     5101 gccttagcaa cagctgaaac agtgatgcgt cagcgcatca cccaaaaaca tatggtcaat
     5161 ggggtgactt tccaaaatcc tgaaaccgtt tatattgaaa gcgatgttga gattgctcca
     5221 gacgtcctta tcgaaggaaa tgtgaccttg aaagggcgta cacatatcgg ctcaggaact
     5281 gtcttgacga atggtactta tattgtggat tctgaaattg gtgataactg tgttgttact
     5341 aattcaatga tcgaatcatc tgttttagct gcaggagtta cggttggccc ttacgcccac
     5401 cttcgaccag gaacgacctt agatagggaa gtccatatcg gtaactttgt tgaggtcaag
     5461 ggttctcaca ttggtgaaaa aacaaaggct gggcatctga cttatattgg aaacgctcag
     5521 gttgggtctt cagtcaatgt tggggctgga accatcactg tcaactacga cggccaaaac
     5581 aaatatgaaa cagtcattgg agatcacgct tttattggga gcaactcgac tctcattgca
     5641 cctttggaag ttggagataa tgctttaact gcagctggct caactatttc taagacagta
     5701 ccagctgata gcattgttat tggtcgtagc cgccaagtca caaaagaagg ttatgccaag
     5761 cgcctagcgc atcacccaag tcgaagcaaa taattcaaga tctatttagt aaggaggcca
     5821 ggcatgaaat ttgaagaaaa aacgcttaag agacaaacag tttttgatgg tcatattttt
     5881 aaagttgttg tggatgatgt tgaacttccc aacaatctgg ggcaatccaa gcgagaatta
     5941 atttttcatc gtggtgccgt tgctgtttta gctattactc ctgaacgtaa gattgtcctt
     6001 gtcaaacaat accgtaaggc tattgaaagt gtctcatacg agatcccagc gggtaagcta
     6061 gagattggtg aggaaggctc aaagctaaaa gctgctgcac gtgagctaga agaagaaaca
     6121 gcctatacgg ggacattgac gtttttgtat gaattttata cagcgattgg tttttgcaac
     6181 gaaaaaatca cacttttctt agcgacagac ctaacacaag ttgccaatcc caaaccacaa
     6241 gacgacgatg aagttatcga ggtcttagag ttgacatatc aagagtgcat ggacttagtc
     6301 gctcaaggta aacttgctga cgctaaaacg ttgattgctt tgcaatacta tgccttacat
     6361 tttggaggtg agcagtgatg ggaaggccat tgttgaccga tgatatcatc gaaaaagcga
     6421 gacgaatgga aacatttgag ccagatgatg ctgtagactt tgacacaaaa gtaatgacgc
     6481 taccagaaaa agatgaaaaa gcacgcattt ataaaagccg tcggattgaa aatgccaaac
     6541 gcagccaatt gcaatccaaa ttaaatgtga ttttgatagc tgttatgctg ttaattgcca
     6601 tcttggtata tgctatcttt tatctttaaa aaaacgtaag gaaatgatat gaaaatagga
     6661 attattgctg ctatggagga ggagttgtcc ctgctcttag caaacctctt ggatgctcaa
     6721 gaacatcagg tgctttcaaa aacttactat acgggtcgtt ttggcaagca tgagctcgtt
     6781 ctggtacagt caggtgttgg aaaagtgatg tctgctatga cagttgcgat cttggttgag
     6841 catttcaaag cccaagctat tatcaataca ggatcagcag gggcagtcgc ttcacattta
     6901 gcgatcggag atgtggtggt tgcagatcgg ttagtgtatc atgatgtgga tgttactgca
     6961 tttggttatg cttatggtca aatggctggt caaccattat actatgattg tgatccacag
     7021 tttgtggcta tcttcaaaca agtcctaaaa cacgaaaaga caaatggcca agttggtttg
     7081 attgcaacag gagacagttt tgttgctggt cagaacaaga ttgaccagat caaaacagct
     7141 tttagcgacg tgttagcagt agaaatggaa ggtgcagcta ttgctcaagc agcacatact
     7201 gcagggaaac ctttcatcgt tgttcgtgcg atgagtgata ccgcagcgca tgatgccaat
     7261 attacttttg atcaatttat tatagaagct ggcaagcgtt cggcccagat attaatgaca
     7321 tttttagaaa acttacctgt ttaactcacc ttatcgtgag acaattagct ggataatctc
     7381 tattttagga gtctggtcac ctcttgtttt gaaacctaaa aataagaatt gcaatcactt
     7441 gaccaaacgc tataatgggt taaggaacga tagattacta aaaggagtct aaaaatgaca
     7501 ataaaaaaac actattatct tctcagtctg ctagctcttg taacggttgg tgctgccttt
     7561 aacacaagcc agagtgtcag tgcacaagtt tatagcaatg gaggatatcg tcaaggtttg
     7621 actgatgaaa aatcacacct gcaatatagt aaagacaacg cacaacttca attgagaaat
     7681 atccttaacg gctaccaaga tgacctaggg agaaactact ctagctatta ttactacaac
     7741 ctaagaaccg ttatgggact atcaaaagag caaaagattg aagaacacta tgaaaagctt
     7801 aaagatgagc tataccgcat gtacaatcat tattaagtca aaggcttaaa aatggcgact
     7861 agcccctcaa aaagaggcca cactcattta aatttaaatg agtgtggcct ctttttgagg
     7921 agacgcaagg ggttaaaggg ctgtgacata gagctgctta gcaatatttt cagggatgac
     7981 aagttccttg tcgccataac aaatcgtata ggtttttgca aaggtatcaa tttgagttaa
     8041 ggttagctcg gtattgatat tgaggtgatg tgtttctaga tactggatta aatcaaagtg
     8101 gtcgtggatt ctgcttaggc gaaaccgtcc caactccgtg atggtgttga gagttgtagt
     8161 gttcatttcg acaagaggct gaccatagcg aggaatagtc cctccgtgtg ggcagaaatc
     8221 tggaaaatca aggatcttgt ctaaacgatc gataaaggtg tctgagacag tgtgctctaa
     8281 gacttcagct tcttggtgca cttcttgggt attatagccc agctgatgaa ttaaaaatac
     8341 ctcaatcaag cggtgtttgc ggtagaggtt agcaacaaga gcatagcctt tgtcttttag
     8401 caaatagcct tttgctttat ctttgacaat ccagccttgt gaaatcattt ttttaatcat
     8461 ctctgaaacg gcaggtgccg aaacgtgcat cttttctgca accattttat ttgtaatctt
     8521 gggttcttgt tctccaattt catagataca tttcaagtaa tcttctttat taggcgtcat
     8581 atcgtttggc ctttctctta tttataatga ttattatatc agaattttta ggaaaaagct
     8641 tgacaaaaag cctaaaagag gatatcctta tagcataatt aactaaactt aattaaataa
     8701 ataatatatc ctaaggagag aaatgatggg aaagagaatg agcctcattt tgggtgcttt
     8761 tttatctgtt tttcttttag tagcttgttc gtcaactggc actaaaactg ctaagagtga
     8821 taaattaaaa gtcgtggcaa ccaattcaat tattgccgac atgacaaaag ctattgctgg
     8881 tgataaaatc gatctgcaca gcattgtgcc aatcggtcaa gaccctcatg agtacgaacc
     8941 attaccagaa gatgttgaaa aaacaagtaa tgctgatgtg attttctata atggtatcaa
     9001 tctagaagat ggtgggcaag cttggttcac taaactagtg aaaaatgctc aaaaaacgaa
     9061 aaacaaagat tactttgccg tgtctgatgg cattgatgtg atttacttgg aaggtgcaag
     9121 cgaaaaagga aaagaagatc cacatgcttg gttaaatctc gaaaacggaa tcatttattc
     9181 aaaaaacatt gccaaacaat tgattgcaaa ggatcctaaa aacaaagaaa cttatgaaaa
     9241 gaacctaaaa gcttatgtgg ctaaattgga aaaactagac aaagaagcta aatcaaaatt
     9301 tgatgctatt gcagaaaata aaaaattgat tgtgactagt gaaggctgct tcaagtactt
     9361 ttcaaaagct tacggtgtcc catctgctta tatctgggaa attaacaccg aagaagaagg
     9421 aacaccagat caaatttcat cattgattga aaaactaaaa gtcatcaagc catctgcgct
     9481 ttttgtagag tcaagtgtcg atagacgccc tatggaaact gtctctaaag atagtggtat
     9541 tcctatttat tctgagatct ttacagattc aattgctaaa aaaggtaaac ctggcgatag
     9601 ttattatgct atgatgaaat ggaaccttga caaaatttct gaaggtctag caaaataaga
     9661 taacaataaa gcacagcgat tttagtgttg tgctttgttt tatttatgta aaggagacaa
     9721 aatgattaca actaacaatc tttgtgtgac ctacgatggc aacagtaatg ctttagaagc
     9781 gattaatgtg acaattgatg gtccttctat cgttggtatt atcggtccta atggagctgg
     9841 aaaatcaacc tttatgaaag ctatcttaaa tcttattgat tatcaaggtc acgtaacggt
     9901 tgatggcaaa gatggtcgta agcttgggca tacagtagct tacgtagaac aacgaagcat
     9961 gattgactat aattttccta ttactgttaa agaatgtgtg gcgctaggga cttatagtaa
    10021 attaggtctt tttcgccgag taggaaaaaa acaatttgag caggttgata aggttctcaa
    10081 acaagttggt ttagaagact ttggccatcg accgataaaa tccttatctg gtggtcagtt
    10141 tcagcggatg ttggttgcgc gttgcttgat tcaagaatca gactatattt tcttagatga
    10201 accgtttgtt ggcattgact cggtcagcga aaaaatcatt gtagatcttt tgaaagagct
    10261 caaaatggct ggcaaaacga ttttaattgt acatcatgat ttgagcaaag tagagcatta
    10321 ttttgacaaa ctcatgattt taaataaaca tttggtggct tatggcaacg tttgtgaggt
    10381 atttactgtt gataccttgt caaaagctta tggcaatcat ttgattttag gaaaggagat
    10441 ggtgtaaatg tctatgaaat tttttgaggg cttgatgtca taccactttt tacaaaatgc
    10501 actgataacg gctgtagtca ttggtatcgt ctcaggtgct gtagggtgtt ttattatcct
    10561 taggtcaatg tctcttatgg gtgatgccat ctcacacgct gttttaccag gggttgcttt
    10621 gtcatttatt ttaggagtca atttttttat tggagcgatt atttttgggt tattagcttc
    10681 tgttattatt acttatatca aggaaaactc tgtcattaaa ggagatacgg ctattggtat
    10741 cacctttagc tcttttttgg cactgggagt catcttgata ggggtagcca atagttcgac
    10801 ggacttattt catattttgt ttgggaatat tttagctgtg caagacagcg ataagtggat
    10861 tactattggt gtttcgattt ttgttttagg ggttattagt ctctttttca aagaactatt
    10921 attaacatca tttgatccta tcttagccaa atcaatgggt gtgaaggtca atgcgtatca
    10981 ttatttgttg atggtcctat taactttagt ggctgttaca gcgatgcaaa gcgtgggtac
    11041 tatcttgatt gttgccttat tgattacgcc agcagcgaca gcttatttat atgctaatag
    11101 cttaaaagta atgttagtga tgtcatcttt actaggcgct ttagcatcgg ttttagggct
    11161 ttatttgggc tataccttta atgttgccgc agggtcaagt atcgtactga cttctgcgat
    11221 gatgtttttg atcagtttct ttgtttcacc caagcaaggc tacctcaaaa gatggatgca
    11281 aaaaaaagaa aaaacacctt aaacttttcg ctttaaacac cttagtggtt tgcaaatagt
    11341 agcaaataac atcaaagggt gttttttata tgtcatcaaa agaccataaa aaaccttatc
    11401 aaaccaaggt atttagccta ttatctgata aggttttttt aagcatgatt tagtttttaa
    11461 agcgataatc tttgacaatg tcaattgagg taatcgtaat gtcttgttct ggtttatcat
    11521 tttggttgat agaagtcgcg gcaattttat cgacaacatc cataccatca atgacttgac
    11581 caaatacagt ataaccgcca tctaagcttg gattgccgcc atgctcatag gcagagatga
    11641 taggttttgg gtagttggta cttgataatc ccttgctttg atttttcttg ttttggttga
    11701 tataaaattg gctaccgtta gtattagcac cagcatttgc catggcaaga gcaccgcgaa
    11761 tatgatataa aaatggagag atttcgttga caaagccatt gccagcatct tttttaggat
    11821 ccttgccctt ccaaatcgat tcaccacctg tgccatctcc tttggggtca cctgattgaa
    11881 tcataaagtc gttgatcaca cgatggaaag taaggttatc atagtagcct tttttagcat
    11941 gggtgaggaa gttctcaaca gctaagggag catattttgg gaataactta agggtaatgt
    12001 ccccttgact tgtcctcatt acgaccttag cttcttcttt gccgacttct ttggttagtt
    12061 gtggaaattg gctagcatca gctttgagag ctttttgaat gctttcttca taggctttag
    12121 aagctgcttc gctttcttct ttggcagttt tttcatcaat gtatttatcg ccttttatag
    12181 cgcggtcaac agattcacaa gcactcaaac taagtaaact aatggctact aaactgagag
    12241 ataataattt tttcatgtct actcctaaga atgattttct ttattttatc ataaaatgca
    12301 acagaaaata gtagtaaaga gttaaaaacg cctatttttg tgttttatga tctaaccttg
    12361 gttaaaaggc tgctacgact gttattatag cacaagatgc tatagaaaaa cttaaaatac
    12421 cttggttttt tagagctatt tcctaatagt taaaaaatgg tataatagtg ttatggttaa
    12481 aagaaatcaa agaagaaaaa gtgcgcctaa gaagcgtctg acaaaagcag aagtggaaaa
    12541 gcaacgtgcc attaagagga tgattttatc tgttttaatg gctttgttgc ttatttttgc
    12601 gatgcttcgc ttgggcgtct ttggcgtgac aacttataat atgattcgtt ttttggtggg
    12661 tagtttagcc tatccgttta tgtttgcctg gttaatttac ttattttgtt ttaaatggtt
    12721 acggcaaaaa gatggaatga ttgcgggagt tgttattgcc tttttgggat tgctagttga
    12781 gtggcacgcc ttcttatttg cgatgcctag gatgcttgat caagatattt ttctaggcac
    12841 tgcgcggcta attacaagag atttactagc cctgcgcgtg actgaatttg ttggtggagg
    12901 aatgcttggt gcattacttt ataaacccat agccttttta ttttcgaata tcggctctta
    12961 ctttattggt tttttgttta tcttattagg attatttcta atgacgcctt gggatatcta
    13021 tgatgtgagt caccttgtga aagaggctgt tgataaacta gcagtggctt atcaggaaaa
    13081 taaagaaaag cggttcatca aacgagaaga gcaccgctta caagctgaaa aagaggcttt
    13141 agagaaacaa gcacaagagg aagaaaaacg tctagcagaa ttgacggttg atcctgagac
    13201 gggagagatt gttgaggata gtcagtctca agtcagctat gatttggctg aggatatgac
    13261 aaaagagcca gagattcttg cttatgatag tcacctcaaa gacgatgagg caagcttatt
    13321 tgaccaagaa gacttggctt atgctcatga ggaaattggg gcttatgact ctttatctgc
    13381 tttagcatct tctgaagatg agatggatat ggatgaacct gttgaagttg atttcacacc
    13441 aaaaacccat cttctttata aacttccaac gatagattta tttgcaccag ataagcccaa
    13501 aaaccagtcc aaagagaaaa acttagtccg caaaaatatc aaggtgcttg aagatacctt
    13561 ccaaagtttt gggattgatg tcaaggtaga acgagcagaa atcgggcctt ccgtcaccaa
    13621 atatgaaatt aaaccagctg tcggggtccg agttaatcgt atttcaaatc ttgctgatga
    13681 tttggcactt gctctggctg ctaaagatgt tcgtattgaa gcaccaattc ctggaaaatc
    13741 attaataggt attgaagttc ctaactcaga aattgcaacg gtttctttcc gcgaactttg
    13801 ggaacaatct gatgccaatc ctgaaaacct tttagaagta ccactaggta aagctgttaa
    13861 tggcaacgct cgcagtttta acttagctag aatgccgcat cttttggtag ctgggtcaac
    13921 tggttcaggt aaatctgtgg cagttaatgg cattatttca agtattttga tgaaggcacg
    13981 tccagatcaa gttaagttta tgatgattga ccccaaaatg gttgaattat ctgtttataa
    14041 tgatattcca catttattaa tccctgttgt aaccaatccg cgtaaagcca gtaaggcact
    14101 ccaaaaagtg gttgatgaga tggaaaaccg ctacgagtta tttagtaaaa ttggtgtgcg
    14161 taatatagca ggttataata caaaggttga agagtttaat gcttcttctg agcaaaaaca
    14221 aataccgttg cctttaatcg ttgtcattgt agatgaattg gctgacttga tgatggttgc
    14281 tagtaaagaa gttgaagatg ctattattcg tttggggcaa aaagcgcgtg cggcaggtat
    14341 ccatatgatt cttgcaactc aacgtccctc tgtagatgtt atttctggtt tgattaaagc
    14401 aaatgttcct tcgcgtatgg catttgctgt ttcaagtggt actgatagcc gtacgatcct
    14461 tgatgaaaat ggtgctgaaa agctcttggg acggggtgat atgctcttta agccgattga
    14521 tgaaaatcac cctgttcgct tgcaagggtc tttcatctca gatgatgatg tggagcgtat
    14581 tgtcaacttt atcaaagacc aagctgaagc ggattatgat gacgcctttg atcctggtga
    14641 agttagcgac aatgatcctg gtttttctgg aaatggcgga gctgctgaag gtgatcctct
    14701 ttttgaagaa gcaaaagcct tggtcttaga gacacaaaaa gctagtgcct caatgattca
    14761 aaggcgtttg tcggttggat ttaatcgtgc cacgcgcttg atggatgaat tggaagaagc
    14821 aggtgttatc ggtccagcag aaggaaccaa acctcgtaag gtattgcaga caaactaaaa
    14881 gaacctgacg tctcataatg agatgtcagg ttcttttttt gtgatgtcag gccagttgat
    14941 gagatgccta tgctaatgta aaaataaaga taactagaat aaggtagaaa ataacggtga
    15001 ctaaaaagcc aactcgccaa aatagcttca taaagcgatg gtaagaaaac gactgagttc
    15061 ggatgactag cagtagtgaa atgacgatgg ctagcagcga catgataata agataataag
    15121 gcagtaaatt atgggtgaaa aattttcctg agacaagcac aatttctatc gcaaaaagta
    15181 aaagtgcgac atctggaaaa ttaaatccct ttttattaag tttaaataaa gaggttacaa
    15241 tcatggcaaa aagaggcgtt actatcaaga aagctaaggc agttaattta tagatcatca
    15301 taggtctatt ttatactcaa atcccttact tgtaaactga tacttacctg ttgtgataga
    15361 aactgatctt tgagagggaa agagcctgct tcaatttaaa tattgcaaaa ggcatcagct
    15421 attttaacaa aaagacttga tttattttgg caataagcta taatggtaag gtatgcaata
    15481 ttgcatatct gtgggaggta aaaatctcaa ttaccgccaa aaccacaaca ggaggatttt
    15541 taaaatggct aaaaaagtcg aaaaacttgt aaaacttcaa atccctgctg gtaaagctac
    15601 accagctccg ccagttggac cagctcttgg tcaagcaggt atcaacatca tgggcttcac
    15661 taaagaattt aacgctcgta cagctgatca agctggtatg atcatcccag ttgttatctc
    15721 agtttatgaa gacaaatcat ttgatttcat cactaaaaca ccaccagctg ctgttctttt
    15781 gaaaaaagct gcaggtgttg aaaaaggctc aggtacacct aacactacta aggttgcgac
    15841 agttactcgt gcacaagtac aagaaattgc tgaaactaag atgccagatt tgaacgctgc
    15901 aaacattgaa gctgcaatgc gtatgatcga aggtactgct cgttctatgg gattcactgt
    15961 tactgactag tcagtcaaga acccctatta cccgcacgac ttcatcataa gagatgagtg
    16021 acgtgggaga ttttaaatca aatcgatatg accacattac aaggagaatt ttaaaatggc
    16081 taaaaaaagc aaacaaatgc gtgctgcact tgaaaaagta gatagcacaa aagcgtacag
    16141 tgtagaagaa gctgtagcat tagtaaaaga aacgaacttc gcaaaatttg atgcgtctgt
    16201 tgaagttgct tacaacttga acattgacgt tcgtaaagca gaccaacaaa tccgtggcgc
    16261 aatggtattg ccaaacggaa ctggtaaaac acaacgtgtt cttgtttttg cacgtggtgc
    16321 aaaagctgaa gaagcaaaag cagctggtgc agacttcgta ggtgaagacg accttgttgc
    16381 aaaaatcaat ggtggatggc ttgactttga cgttgttatc gcaacgccag acatgatggc
    16441 tatcgtaggt cgtcttggac gtgtccttgg acctcgtaac ttgatgccaa accctaaaac
    16501 tggtacagta acgatggatg ttgccaaagc cgttgaagag tctaaaggtg gtaaaatcac
    16561 ttaccgtgct gacaaagcag gtaatgttca agctcttatt ggtaaagttt catttgatgc
    16621 tgacaaattg gttgaaaact tcaaagcctt ccacgatgta atggctaaag ctaaacctgc
    16681 aacagctaaa ggaacttaca tggcaaacgt ctcaatcaca tcaacacaag gtgttggtat
    16741 caaggttgat cctaactcac tttaagaaaa aaattagggc atcgcctaat catagcaaaa
    16801 agacaaattt ctgaagacaa atcttcacta gaggtttgtc ttttttatgg tttaaaatgg
    16861 aatgcaaaca aaaaagtgta ggcgataata ccatgaaagg agttgattcc cttaatgaga
    16921 tgtggtgtta acacatcatg agctcacaaa aaatgataaa ggaagtatcg gtggtgttaa
    16981 aaaagggatt ttaattgata tttattagcc tctaaaatgt cctttcccta ttcataattg
    17041 agggtttgtg gtaaaatagt aaggacaaac taaggagaac atagtagtgg aacctaaata
    17101 tcaacgtata ttaattaagt tatctggtga agcattagca ggtgaaaaag gagttggcat
    17161 tgacattcca actgttcagg ctattgcaaa agaaattgcc gaagttcatg tgtcgggagt
    17221 acagatcgct cttgttattg gtggaggcaa tctctggcgt ggagagcctg cagcagacgc
    17281 tggaatggac cgtgttcagg ctgattacac tggcatgctt ggaacggtga tgaatgccct
    17341 agtcatggct gatagtcttc aacattatgg tgttgatacc cgtgtgcaaa cagctattcc
    17401 tatgcaaaat gtagcagaac cttatattcg cggacgtgcc ttgcgccatc tagaaaaaaa
    17461 tcggattgtt gtttttggag ctggtattgg ctcgccttat ttttcaacag acaccaccgc
    17521 ggcactgcgt gctgctgaga ttgaagcaga tgctatttta atggcaaaaa atggtgtgga
    17581 tggggtctat aatgctgatc ctaaaaaaga tgctaatgcg gttaaatttg atgaattaac
    17641 acatggtgaa gtgatcaaac gtggtctcaa aatcatggat gcaacggcat cgaccttatc
    17701 gatggataac gatattgatc tggtggtttt caatatgaat gaagctggca atattcaacg
    17761 tgttgtcttt ggagaacata ttggaactac tgtatcaaat aaagtttgtg actaaaagtt
    17821 agaaaagaaa gagagtaatt atcatggcaa atgcaattat tgaaactgca aaagaacgtt
    17881 ttgcacaatc ccatcagtct ttatcacgtg aatatgccag cattcgtgcg ggtcgtgcca
    17941 acgctagtct tttagaccgt atccaagttg attattacgg ggcaccgacg ccattaaatc
    18001 aattggcttc aatcactgta ccagaagcgc gtgtcttatt gatctcgcct tttgataaat
    18061 cttctatcaa agatatcgag cgtgctctta acgcatcaga tttaggcatt acacctgcta
    18121 acgatggctc tgtcattcgt ttggttattc cagctttgac cgaagaaaca cgtaaagaat
    18181 tagccaaaga agtgaaaaaa gttggtgaaa atgctaaaat tgcaatccgt aatatccgcc
    18241 gtgatgctat ggatgatgct aaaaagcaag aaaaagcaaa agaaatcact gaagatgagt
    18301 taaaaacact tgagaaagat atccaaaaag caaccgatga tgctatcaaa gaaattgacc
    18361 gcatgacggc tgaaaaagaa aaagaattgc tctcagtgta acaggattcc tacgaaaaat
    18421 agacgactat agacacaaaa agataggtga ccatttcaga agcgtttggt tttgatttgt
    18481 ccctattttt ttaaagaaag aaaaaagata tgaatgattt actagcaaca gtcattactg
    18541 ggcttattaa agaagaaaac gctaatgact attttatcca aaaagaaggg tttaccttta
    18601 ccttgtctaa agcagaagga gaacgccagg ttggtgatat ggtcacaggc tttgcctata
    18661 tagacatcaa gcaaaaggca cgtctcacaa ccaaagagat ccgttcaaca cggacaagtt
    18721 atggctgggg ggaagtgaca gagattcgtc gtgacctagg cgtttttgtc gatacaggaa
    18781 ttccaaataa agaaattgtg gtctctttgg acgtgttgcc tgaaatgaaa gaactatggc
    18841 ctaaaaaagg ggataaactt tacattcgtt tggatgtgga taaaaaagac cgtatttggg
    18901 gacttccagc agagcctgag gtctttcaaa aaatggccag tcctgcatac aataacatgc
    18961 aaaatcaaca ttggccagca attgtttacc gcctaaaatt aacaggaact tttgtttacc
    19021 tgcctgaaaa caacatgttg ggctttattc acccaagtga acgctacgca gaaccgcgct
    19081 taggtcaggt tttagatgcc cgtgtgattg ggtttagaga ggtcgatcgt accttgaatt
    19141 tatcgttgaa accacgttct tttgagatgt tggagaatga cgctcagatg attgtcacct
    19201 atctggaagc caatggtggt ttcatgacct taaatgacaa atcaagtcca gaagagatta
    19261 aggcaatctt tggtatttca aaaggccagt ttaaaaaagc cttgggtgga ttgatgaaag
    19321 ctaaacgcat caaacaagac gccacaggaa ctgaattaat aggataaaaa aactttgcca
    19381 ctggcaaagt tttttgttac aatgaagacc attaagtgaa gaaaaagggg atatagagaa
    19441 tggaaagagc catttttgca ggaggttgtt tctggtgtat ggtgcaacct tttgaggagc
    19501 aagcaggtat tttgtcagtc agaagtggct acacaggtgg gcatctccca aatcctagct
    19561 atgaacaagt ttgtgccaaa acaacaggac atacagaagc tgttgaaatt atttttgacc
    19621 ctgaagagat cagctataag gaattagttg aattgtattg ggcgcagacg gatccaacag
    19681 atgcctttgg gcaatttgaa gatcgtgggg acaactaccg tcctgtcatt tactatacaa
    19741 cggaaagaca aaaagaaatt gcagagcaat caaaagcaaa cttgcaagct tcaggacgtt
    19801 ttgaccaacc cattgtcacc actattgaac cagcagagcc attttatctc gcagaggatt
    19861 atcaccaagg tttctataaa aagaatccca agcggtatgc acaaagcagt gctattcgtc
    19921 atcagttttt agaggagaac tggtcatgag aaaatcattt tacagctggc tgatgacaca
    19981 acgtaaccct aaatcaaatg aacctgtggc gattttagca gatttggtgt ttgatgacac
    20041 cacttttcca aagcatacca atgattttga actcattagt cggtatctag aagatcaagc
    20101 tagtttttcc tttaatttag gtcaatttga tgaaatctgg gaagattatc tagcacatta
    20161 atacgtggat aaaaaagagt catatcgact cttttgaagg gttatcacgt tattattaca
    20221 aaatgacatc actttctttc aaaaaaatga caagctactt tttttcttaa aaatatgcta
    20281 tgatatagct tagaaaaaaa taaaaaggaa gcagagatga ttattactaa aaagagctta
    20341 tttgtgacaa gtgtcgcttt gtcgttagca cctttggcga cagcacaggc acaagagtgg
    20401 acaccacgat cggttacaga aatcaagtct gaactcgtcc tagttgataa tgtttttact
    20461 tatactgtaa aatacggtga cactttaagc acaattgctg aagcaatggg aattgatgtg
    20521 catgtcttag gagatattaa tcatattgct aatattgact taatttttcc agacacgatc
    20581 ctaacagcca actacaacca acacggtcag gcaacgactt tgacggttca agcgcctgct
    20641 tctagtccag ctagcgttag tcatgtacct agcagtgagc cattacccca agcatctgcc
    20701 acctctcaat cgactgttcc tatggcacca tctgcgacac catctgatgt cccaacgaca
    20761 ccattcgcat ctgcaaagcc agatagttct gtgacagcgt catctgagct cacatcgtca
    20821 acgaatgatg tttcgactga gttgtctagc gaatcacaaa agcagccaga agtaccacaa
    20881 gaagcagttc caactcctaa agcagctgaa acgactgaag tcgaacctaa gacagacatc
    20941 tcagaagatt caacttcagc taataggccg gtacctaacg agagtgcttc agaagaagtt
    21001 tcttctgcgg ccccagcaca agctccagca gaaaaagaag aaacctctca gatgttaact
    21061 gcgccagcag cacaaaaagc tgtagctgac accacaagtg ttgcaacctc aaacggcctt
    21121 tcttacgctc caaaccatgc ctacaatcca atgaatgcag ggcttcaacc acaaacagca
    21181 gccttcaaag aagaagtggc ttctgccttt ggtattacgt catttagtgg ttaccgtcca
    21241 ggagatccag gagatcatgg taaaggtttg gccattgatt ttatggtgcc cgaaaattct
    21301 gctcttggtg atcaagttgc tcaatatgcc attgaccata tggcagagcg tggtatttca
    21361 tacgttattt ggaaacagcg attctatgcg ccatttgcaa gtatttacgg accagcctac
    21421 acatggaacc ccatgccaga tcgcggcagt attacagaaa accattatga tcatgttcat
    21481 gtctccttta atgcttaatt catgctatca aaaaaaactc acgtttaggc gtgagttttt
    21541 tgacaattct gacagagtaa gccctataag aggctgagat acgcttttaa tacctgttgt
    21601 ttttctcacc ctttagacag ttttaacgtt atgtctaaaa gagatggttt ttattagcgc
    21661 aaatatgggt ttaggggtaa aatataggta attaacctga tatgatcatg ataaaggtag
    21721 aagaatacct attatttcgt gacaactgag caatctgccc ttacctttgg agtgatgata
    21781 tcactttgct tgactattca aggaggtctt gaaatgtatt atactagtgg taattacgaa
    21841 gcttttgcga cacctcgaaa acctgaaggg gtagatcaga aatcggctta tattgttggt
    21901 actggtttag ctggtttagc agcagctgtt ttccttattc gcgatgggca tatggctggg
    21961 gaacgcattc gtctgtttga ggaattgcct ttagcaggtg gttctttaga tggtattgaa
    22021 aagcctcatc ttggttttgt gacccgtggt ggtcgtgaga tggaaaatca ttttgagtgt
    22081 atgtgggaca tgtatcggtc tattccctca ctggaaattc ctggtgcgtc ttatttggat
    22141 gaattttatt ggttggataa ggatgatcct aactcatcca actgtcgttt gattcacaag
    22201 agaggaaatc gtgtggatga tgacggccag tatacgctcg gtaaacagtc aaaagaatta
    22261 atccatttaa tcatgaagac agaagaatct ctaggagatc aaaccattga agagttcttc
    22321 tcagaagatt tctttaagag taatttttgg atctattggg caaccatgtt tgcttttgaa
    22381 aaatggcatt ctgctgtaga aatgcggcgc tatgcgatga ggtttatcca ccatattgat
    22441 ggtttgccag atttcacctc tctcaagttc aacaaatata accaatatga ttctatggtc
    22501 aaaccgatta ttgcttacct agaatcacac gacgttgaca tccaatttga cacaaaagtc
    22561 actgatattc aggtggaaca aacagctggt aaaaaggtag caaaaaccat ccatatgacg
    22621 gtgtctgggg aggctaaggc gattgagcta acacctgatg atttggtttt tgtgaccaat
    22681 ggttctatta ctgaaagtag cacatacggt agtcatcacg aagtggctaa gccaaccaaa
    22741 gcgttaggtg gttcttggaa tttatgggaa aatctagctg ctcaatcaga tgattttggt
    22801 catcctaaag tgttttacca ggacttgcct gctgaaagct ggtttgtgtc tgccacagca
    22861 accataaaac acccagctat cgagccttat attgaacgtt tgacccaccg tgatttgcac
    22921 gatggcaaag tgaacactgg cggcatcatc actattacag attctaactg gatgatgagc
    22981 tttgccattc accgtcaacc tcattttaaa gaacaaaaag ataatgaaac cactgtctgg
    23041 atttacggtc tttattccaa tagtgagggc aattacgtcc acaagaaaat tgaggagtgt
    23101 acaggtcaag aaatcacaga agaatggttg taccaccttg gggtacctgt tgataaaatc
    23161 aaggacttag cgagtcagga ctatatcaat acagttcctg tttacatgcc ttatattacg
    23221 agttacttta tgccacgtgt caaaggagac cgtccgaaag ttatcccaga tggttcagtc
    23281 aacttggcct ttattggtaa ctttgcggaa tctccatctc gagatacggt ctttacgact
    23341 gagtattcta ttcgtactgc catggaagca gtgtatagct tcttgaatgt ggaacgaggc
    23401 attccagaag tctttaattc agcctatgat attcgtgaat tgctcaaagc cttttattac
    23461 cttaatgata aaaaggcaat caaggatatg gatttgccaa ttcctgcact gattgagaaa
    23521 atcggacata aaaaaatcaa ggataccttt atcgaagaat tgctcaaaga tgctaatctt
    23581 atgtaacatg ccttagagta gttaaagctg ataagtttag gcttatcagc ttttttgatg
    23641 atttatagaa aagtgataaa ggaaaagtct gacgtgaacg tcacataaga atttaaaatt
    23701 tgttataatg taagcaataa agatgaaaga aagagggact ctatttgcaa gagtattcta
    23761 ttgacattac cttaacccat cctgatgatg ttttagctct ttttggtagc aacgagcgtc
    23821 atttgaagct aatagaagct catttaggag ttattgttca cgcaagaacc gagcgagtcc
    23881 aagtgattgg tgatgatgaa gaagctgtgg aattggctcg attgaccatc aaagccctac
    23941 tggttctagt gggtcgtggc atggtggtca acacatcaga tgtggtgaca gctttatcta
    24001 tggcagaatc tcatcagatt gaccaattta tggcgcttta tgaagaagaa atcattaaag
    24061 ataactatgg taaggcaata cgagtcaaaa cattaggtca aaaaacctat gttgatagtg
    24121 tcaaacgtca tgatgtggtt tttggtgtag gacctgcagg gacagggaaa accttcttag
    24181 ctgttacgct tgcagtcact gctctgaaaa gaggacaggt aaagcgtatt attttgacgc
    24241 gtcctgcggt agaagctggt gaaagcctag gttttttacc aggcgatttg aaagaaaagg
    24301 tggatcctta cctcagacct gtttacgatg ccctttatca cattttaggc aaggaacaaa
    24361 ccacacgcct gatggaacga gatgtgattg agattgctcc gttagcttat atgcggggtc
    24421 gtactctgga tgacgctttt gttatcttag atgaggctca aaacacgacc atcatgcaaa
    24481 tgaagatgtt tttgacccgt cttggtttta attctaaaat gattgtcaat ggagatacga
    24541 gtcagattga cctccctcga aatgtcaagt ctggtttgat tgatgctact cagaaattac
    24601 aaggcattaa acagattgat tttgtctatt tctctgctaa ggatgttgtc cgacatcctg
    24661 ttgtggctga tattatcaag gcttatgaaa cgtcctcaga ggagatgaag gacttactaa
    24721 aacctaaggc tagtgacgtt gaagctgatt accagccagg cttgacaaaa taccctgtga
    24781 ttggtcaaga gcactaagat ttttacgatg atgtttaata tggccttttt aaggaggatt
    24841 ctatggatga tttaaccaaa gctattatgg cagatgaggc taatctctcc tataccgaaa
    24901 gaggtatttt tcctttatat gatgctcctc aaacagctag gattattatt gttggccaag
    24961 ctcctggaat agtagctcaa gaaaccaaac tttactggaa tgatcgtagt ggcatccgct
    25021 tacgagactg gctaggtgtg gacaatgaca ccttttacca ctcaggattg tttggcatta
    25081 tccctatgga tttctattat cctggtaagg gaaaatccgg tgacttacca cctagagaag
    25141 gttttgcggc taagtggcac ccgccattaa gagcattgat gccagaagtt gaattgacga
    25201 ttttggttgg tcgctatgct caggactttt accttggtaa caaggcttac aaaaccttaa
    25261 ctgaaacagt ccgtcacttt gaggattact tgccagacta ttttccactt gttcatcctt
    25321 ctccaagaaa ccaattgtgg ttagctaaga acccctggtt tgagcaggat ttattaccta
    25381 tcttgcaaaa acgtgtggag gcaattctaa ccaaataggc cctgatttac ctagcattcc
    25441 catttttaag gggcttgtgg tataatgggt aaataacaaa tgctgattga aaggataagg
    25501 gaaattatct gtcagataat aatgggtgcc caacatacca aatgaggtgg gcagcccttc
    25561 cctaacaatt aaccttatgt atatcgagat gattgacgaa acgggacaag tttcgcaaga
    25621 gattatggag caaacacttg atttgctcaa ttttgctgct caaaagacgg gcaaagaaga
    25681 aaaagaaatg tctgtgacct ttgtgaccaa tgaaagaagt catgaactca acttagaata
    25741 ccgagatact gatcgtccaa cagatgtgat ttctctagaa tataagccag aaacgcctat
    25801 tttatttagt caagaggatt tggctgctga tcctagtttg gcagagatga tggcagagtt
    25861 tgatgcttat attggcgaat tgtttatttc tattgacaag gcgcgtgagc agtcccaaga
    25921 atatgggcac tcttttgagc gtgaaatggg atttttagct gttcatggat tcttacatat
    25981 taatgggtat gatcactaca cccttgaaga agaaaaagag atgtttacct tacaggaaga
    26041 gattttgact gcttatggcc ttacacgaca ataataccac caaacggaaa tggaaaaaca
    26101 gaaccattac ctcaagcttg gagtttgcct tgacaggggt tttcacagct tttaaggaag
    26161 aacgcaatct cagaagccac cttttgtctg cctgtttagc ttgtgttgct ggtttatttt
    26221 ttagcatttc agccatcgaa tggttatttt tacttctagc catttttttg gtcattacct
    26281 tagaaattgt caattctgct attgaaaatg tagttgattt ggctagtgac tatcactttt
    26341 ctatgctagc taaaaatgcc aaggatatgg cagcaggtgc tgttttgatg atttctggct
    26401 atgctgtctt gacaggactt attattttta ttcctaaaat ttggaatatt ttcgttcatt
    26461 aaaaagaaag gaatgggcta tcctatgtga tgatggcata ggagaataag gaaaggacaa
    26521 gacggttaag cttagtgaca agcttgatct gaagccctac cgttaaggcc cgtaattatc
    26581 tatgtttaaa tcaggctttg tagccattct tggtcgtcca aatgttggca aatccacctt
    26641 tttaaatcac gtcatggggc aaaaaattgc catcatgagt gacaaggctc agaccacccg
    26701 taataaaatt atgggcattt acaccacaga aacagaacaa attgtcttta ttgatacgcc
    26761 aggtattcat aaaccaaaga ccgcccttgg tgattttatg gttgaatctg cttatagtac
    26821 tttacgtgaa gttgagacag ttctcttcat ggtaccagca gatgaaaaac gtggtaaggg
    26881 tgacgacatg attatcgagc gcctaaaagc agctaagatt cccgttatct tagtcatcaa
    26941 taaaattgac aaggtgcacc ctgaccaact tttggcacaa atcgatgatt ttcgtagtca
    27001 aatggagttc aaagaagtag taccgatttc tgccctagaa ggtaataatg tgccaacttt
    27061 gatcaagtta ttaactgata atcttgaaga aggtttccaa tatttcccag aagatcagat
    27121 taccgatcac ccagaacgtt ttcttgtgtc agaaatgatc cgtgaaaaag tgttacacct
    27181 cacccagcaa gaggttccac attccgtagc ggttgtggtc gaatccatga agcgagatga
    27241 ggaaaccgac aaagtgcata tccgtgcaac cattatggtg gagcgcgata gccaaaaagg
    27301 tattatcatc ggtaaacaag gagccatgct caaaaaaatc ggaaaaatgg cacgtcgtga
    27361 tattgaactc atgttaggtg acaaggttta cttagaaacg tgggtcaaag tcaagaaaaa
    27421 ctggcgggat aaaaagcttg atttagctga ttttggctat aatgagaaag aatactaaca
    27481 tagtaaagcg agatcatatg ccacaagact acatttctta tatccgctcc aaagttgggc
    27541 atgataagat tattcttaac tttgctggtg ggattttgac cgatgatgac ggcaaggtgc
    27601 tgatgcagtt gcgtggtgat aagaaaacct gggctattcc tggtggcact atggaactgg
    27661 gtgagagctc tttagagact tgcaaacgtg agttcttaga ggaaaccgga attgaggttg
    27721 aagctgttcg cttactgaat gtttacactc attttgagga agtttatccc aacggtgatg
    27781 ctgttcagac tattgtcttt atctatgaac taacggctgt ttctgatatg gctattgata
    27841 actttcataa tgaggaaacg ctcaagttac aatttttctc tcatgaggag atagcagagt
    27901 tagagagtgt ctcagccaaa catcgcctga tgttagagga atattttagt gatagctttg
    27961 ctatggggca ttaagaactc tctaggacag ttggagtatt tttggagatt ggcttgttaa
    28021 aaaaattttt gaaagacgat attcgagagt ttatgctctc tttttttgct tccaattttt
    28081 ctgattaagt ctgaataatt ttgttaaatg ttaacaggat tttctttcca attgatacta
    28141 gcagacatca aacatttgtt ttagagttat gacgaattgc cacctagcca tgcatgactt
    28201 aggcaagttg aacctaactg tgacaataga cttgggaggg gtgacaagaa tcatttccta
    28261 aaagaattga tgaagtgcct atccattatt cgaattgtaa agttcgtcta agtaaagttg
    28321 aatttggtct cgaatggacc ttaatgattt atgacttgtt gtgtcaataa caccaaaaac
    28381 tcgataatga tttttaaata tttcctcgta attaatatga tttccgatta gaataatatg
    28441 agcatgagga taacgcatac gtatttcgtt tagaaggtca tatacttgct tagatttaaa
    28501 aaagtatgat ttatgataaa ataaacctga catttgtatt tataatctaa gtttttccca
    28561 ctaataattt gagtttttag aaagtatctc ttgaggtaat agttaatata gatagatatc
    28621 atatatccta aaagagaacg atgtaagact tgaataacta tcataatttt ctccacgtat
    28681 tgaacaacca attgactatg tccatcatca acaaggtcaa acgttagctg aagactcctt
    28741 tatttttaaa gatgccaaga ctcaggttca gattccattc agattccatt tgcagactta
    28801 ctttatattg aaacgtcata tattgctcat aaattggttc tttattctac tagagaaagg
    28861 attgaatttt atggggagtt atctgaaatc gttaagcaag aaccaagatt atttcaatgc
    28921 catcgatcat ttgttgttaa tccctacaat atatcttcaa tacaacgatt agaacgtaag
    28981 atttatttaa aaaaacggtt catcttgtct agtatcaagg ctaaaagtta ctgctctaaa
    29041 agaagcagtt gaaaatctac ataataagga gacttagatg agtagcatct tctttctagc
    29101 acttactttt actcatgtca ttattttgat aattttacat gctaaagtat atgtatataa
    29161 agtaactgtg aaaaatcttt cgctttatac gcttttcttt ttttatattc tgcccagttt
    29221 ggaaataggt atcgaatttc aagatatgaa tatcgtttct gatatttatc agaatgtcct
    29281 cttgactagt ggagtgatta gcacctaggg ttaagttttc taagatagat ccactaaaga
    29341 tatgagcttg ttgggggaga tagttgatat gctgacgaag cactttttta tcaatcattt
    29401 taagattttg atgattaata gaaatctgtc ccttgtaagg ttcaaagaaa ttaacaatca
    29461 ttttagctaa tattgtcttg ccagaaccac taataccaac tatactgact ttttcaccct
    29521 ccttaatggt caaactgata tcagataagg tatcacgacc aaagccgtat ttataagaca
    29581 agtctgcaaa ttggatatct ccatatagac aataggtatc tgttaatgcc tgttcttttt
    29641 ggaactcaga tttaaccagg taaacttcat tgagacgatt attagctacc ttagcggatt
    29701 gcagtttagt ttgaagatta atgatatttt accattcata actagtcgtg cacccaccca
    29761 taagatagta acgtttaaaa tgagttgtgc tccttgcttt agactacttt gtagaatact
    29821 tacttaactt gaaagattta tccagatagt ctacaaattc actatcaatt ttctgataac
    29881 gaatttcctc gctagtcaat gatttgattg tttcaatacc attaatatct tcgataatag
    29941 cagagctggc catggaatta ctctgcatga cattgttatt catcttttca aaaggtttca
    30001 taaaagtaaa aatgatgata atgtagattg ggatagaaat taatgataga agaaataggt
    30061 tagtgttttg tacgagtaac acaccaccta caatacttaa aatagagaca tctaaaaata
    30121 gagatagaat tgtagaagca agtgtatcaa taatagcatt agcatctgta aaacgtgaga
    30181 tgatttctcc tgtccgacgt gttacaaaga aagacatggg aagctcaaaa atatgacgaa
    30241 tataggataa aataacatca atgcttaatc gctgactcag tacagtcagg agataatctc
    30301 gcgaaaaact catcatctgt tgtaggatat aggtaacgat aagtccaatt gagattatac
    30361 cgagtgttgg cttcatctga tttggaatat attcatccca aataccttgt agatagtagg
    30421 aaccaccaat atttatcagg gtaactaaga ggctcgctaa aacgatatag aagattaagg
    30481 actcttgttt aaaaattaga ggtagaaaac tcattaagcc attcttttta tccttgtgag
    30541 gtttatagcc aggttcaggt gctaaaaaga tagcaacccc tgtctattca ggagcaaatt
    30601 tttctttgct cattttggtt actttaacgg agggatctgg atctccaatg atgaaatgtt
    30661 cttttcaaag cccatctcct tggccgcttt tacgattcca agggttgttg ttccttcttt
    30721 attagtcttt gccaattctc tcagatgtgt caaagagtag tcagacccgt agaattttgc
    30781 aatcgaagct agagcagcaa ttccacaatc tcttgcatca atttgtggta caaacgtacg
    30841 tttacatgat gtcattaata tatttccttc cagtaaatta caaattcatt attgcaaaac
    30901 tactgataag aaattcgaaa attcttaaat ggtatctagt atatcctgaa tggtatttta
    30961 aaattaaaag taataagttt ctagtgatta ttttctaatt cgaaacgatt aaaaaactat
    31021 gaaaaaaatc atttcatgat gaaaaaagaa catttgaaga ttttacgggg cacagatttc
    31081 ttaagatgct atactgaaca tgtcaaggtt gcaacaagac ataataaaaa attatataag
    31141 gagatattcg ttatgaatac aacaattaaa caatttgaaa ttatggatga ggccatgctt
    31201 actggtattg aaggtggttg ttcatggcat gggttagctc aggcagctgt ttttactggt
    31261 gctggaaatg gatttagatt aggtgttaaa acaaggactt ggcaaggagc tgcagctgga
    31321 gcagctggtg gactggtcat tggaggagtc ggttatgggg cgacttgttg gtggtaataa
    31381 ccatggatat caaaagtttt ttgcttggtt tagttattgg tttactttgc ccaattttcg
    31441 acaatatatt attgaatatc ctgaaaaatt ggaaaaaccg atagaagaca ctaagatggg
    31501 gctttactca gtttatatag gtgatcttta aggatttaac atagcttgga tgtgataggt
    31561 ctcgttggaa taagaaaaag tatactggta aatgttaaaa aataggagca aatagaatga
    31621 gtggtgtctt taagaagtgt cttaccttta ttatgtcaat tatattctct atatttatga
    31681 ctatttttgt tcaaactcca gttgttgcga catttaacaa tgaacggatt aatcttaggc
    31741 aagggatcaa tggagacttt ttaagagtaa taatttgcat tatttttata atactttgct
    31801 tttattttct gtcactctta gcgaaatgtc ttatcagcca gtaaagttca tattattttt
    31861 tttacgactg tagtttctca accaatcttg gaggagattc tatttcgagg aatactgcaa
    31921 gaaaagttat cacgcgtttc gttttggtta agcatcattg tgacatctgt aatattctcg
    31981 tatattcatg gaaatgacac tatattgaat actcaattca tcagttcttt gatatatgga
    32041 atggcttatc aaacaagtaa ggatttaaga tttcctatta ttaaccattc tctgcagaat
    32101 ttaatagtac ttcttacagt tgttttgcta aagtaagtag tgagaattaa taaaaataac
    32161 tgggataatt atagtaatga aaagattttg acaatgacaa aataatttag tgaaataaat
    32221 atgactgagc taacaagtat ttcaggtggc tcccaaaaaa gttattgtgt tggtttgatt
    32281 acaggacgca tctggaagaa gaagcttctt gggcaaaaaa ttgtagtttc agattacact
    32341 ttccgttaat gttattaaag atgcggttga ctatgttgtc ggatttgtag cttcgttagt
    32401 ataataagca ttttatgtca aagccaagct atgtatactg accttgcttt ctagggaata
    32461 ggagagagaa cttagaggca tttcgctggc tttgcatttt gtttatgact atatcttaaa
    32521 cggacatcga aacatcttga atggtagagt gagtcttgga ctcatggata taaaattaag
    32581 ataatatggg tgtttttgaa attatgaatg ttaaaaagac ttcccattta ggaaagttaa
    32641 atgactgttt aggaaatagt gcaggatttt tttaagaagc gctatactga atatgtcaag
    32701 gttgcaactg gacaaaatat aaaaattata taaggagata ttcatgatga atacgaaaac
    32761 aatggaacaa tttgaagtga tgaactctga aatgcttgct ggtgttgaag gaggctgggg
    32821 cggttgggga gaagcaattg ccggtctatt aggaggcttt gctccttcac caacattaga
    32881 tcaattaaat ggcaaatggc caattagaaa accttccaaa ccttgtagtc cttacggaac
    32941 tggtgggaca cctaatacgt gtaatggttt ataaattagg acatatttaa gtgattatgc
    33001 aataaaggaa gtggaggtag atatgctgac tctatacaaa agacaaatcg cagaagtttg
    33061 ggagattggg agagaaacgc ctcagccaga gtgggtacgt gatgcttttc gcaagaatta
    33121 catctgttgg ttggatgagc atgttcgtat tctcatgact ggactaaatc cttcgctgac
    33181 aacaaattta aagattagtg caacaggaac agtaggtgga ggatttgctg gatatggtat
    33241 gtatgtcctt ggttatccag gtgatttctt ggatgtgacc aaccatcgag ttatttctgc
    33301 caaaaaattc cataaagaat atcagattat tgatggatag aaaaagtaga ctatgaactt
    33361 ttatgactgg tttaattttg agggtttaca acaaaaagga gctctttgga agattgtagg
    33421 aagtattttc tttgtcggtt ttcatttatt catcatctat ttggtacaaa gataattagt
    33481 tcaactttaa aaattcatcc caatagtctt tatcgatgga ttcaagaata tgaaaaatat
    33541 ggagaaagtg cgttcccagg acatgggagc gcacttcgtc atgctcaatt tgagacaaaa
    33601 aaacttgaaa aagagcacaa actgctacag gaggaattag ctcttctaaa aaagttccag
    33661 gtcttcttga agccaaactg gaaataaaat ttcagtttct gaaggaaaat agtgttagct
    33721 tgaatagtca tcacgcctgt caaactcttc aagtctcccg ttcaggtttc tatgcttatt
    33781 taaaacgtcg tccctcttca aggcatgttg agaatgaagc tttgaaggaa atgattaaag
    33841 ccattttcta tgaacataaa gagcgttacg gaagtgtacg aattacccaa gaactttgta
    33901 gacgtggcat ccatgtcaat cataaacgtg ttggtagact ccttcatcag ctaggtctct
    33961 atgctaaagg aagtcgatat caatataaat actataaccg tcgacgttct tcatgaactc
    34021 gtcccaatct tgttaatcaa tgtttccaag cgactggtaa gaataaatta tggctaggag
    34081 acttaaccta tattcctaca caagaaggaa tactttatgt gtctgtcttt atagacgttt
    34141 atagtagaaa gattgttggt tgggcaatgg gccgacgtat gcaagacaag ttggtaacag
    34201 aggctttcaa tcaagcttat aatagagaaa agcctaaaga aggggtaatc gtccatacag
    34261 atcagggttc tcaatatacc ggagcacgat ttcaggacct acttagacgg aaaaaatgta
    34321 agtccagtat gagtcgaaaa ggtaatccat acgataatgc actcatggaa tccttttata
    34381 aaacattaaa aagagagctt gtcaatgatg ctcatttcgc aactattaag taagctcagc
    34441 ttgagatttt taaatatagt gagacttact ataaccctaa acgtctgcat tcagctttag
    34501 gatatctctc acctgtagaa tttgaaaaaa ta
//
LOCUS       DAUDWO010000021        33779 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.021, whole genome shotgun sequence.
ACCESSION   DAUDWO010000021 DAUDWO010000000
VERSION     DAUDWO010000021.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 33779)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33779)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33779
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.021"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            134..2332
                     /gene="nrdD"
                     /locus_tag="VHC05_000977"
     CDS             134..2332
                     /gene="nrdD"
                     /locus_tag="VHC05_000977"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011529096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase"
                     /protein_id="HEQ5402296.1"
                     /translation="MVSLEEDKVTVQPDIKVIKRDGRLVNFDSTKIYSALLKASMKVT
                     RMSPLVEAKLEAISDRIIAEIIERFPTNIKIYEIQNIVEHKLLAANEYAIAKEYINYR
                     TQRDFARSQATDINFSIDKLINKDQTVVNENANKDSDVFNTQRDLTAGIVGKSIGLKM
                     LPSHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLANGFKIGNAEVESPKSIQT
                     ATAQISQIIANVASSQYGGCTADRIDEFLAPYAELNFKKHMADAKKWIVETKRESYAF
                     EKTQKDIYDAMQSLEYEINTLFTSNGQTPFTSLGFGLGTSWFEREIQKAILTIRINGL
                     GSEHRTAIFPKLIFTVKRGLNLEPDSPNYDIKTLALECATKRMYPDMLSYDKIIDLTG
                     SFKSPMGCRSFLQGWKDENGQDVTSGRMNLGVVTLNLPRIAMESNGDMDKFWELFNER
                     MLISKDALIYRVERVTEAKPANAPILYQYGAFGKRLEKTGNVNDLFKNRRATVSLGYI
                     GLYEVASVFYGGQWEGNPDAKAFTLSIVKAMKQACEDWSDGYGYHFSVYSTPSESLTD
                     RFCRLDTEKFGIVTDITDKEYYTNSFHYDVRKSPTPFEKLDFEKDYPEAGASGGFIHY
                     CEYPVLQQNPKALEAVWDYAYDRVGYLGTNTPIDKCYNCQFEGDFTPTERGFTCPNCG
                     NNDPKTVDVVKRTCGYLGNPQARPMVNGRHKEISARVKHMNGSTIKYPGL"
     gene            2516..2662
                     /locus_tag="VHC05_000978"
     CDS             2516..2662
                     /locus_tag="VHC05_000978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402297.1"
                     /translation="MGKYQLDYKGMQQVERFHEKHSKKKTDKKSRLQELKARFLEKSK
                     KQDN"
     gene            2691..3626
                     /locus_tag="VHC05_000979"
     CDS             2691..3626
                     /locus_tag="VHC05_000979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HEQ5402298.1"
                     /translation="MLNIGIVGLGAISQKAYLPYMRQLSDITWHLSTRNAAVRQQVGQ
                     LFGHAILYSDVKELSKTNLDGIFIHAATSAHAELASLFLNQGIPVFMDKPIADNYLMT
                     KNLYDLAKENQTFLMAGFNRRFTPRVKKLSSLSTKRKVAVEKNDLNRPGDMAFKLFDF
                     FIHPLDTALFLTEGTLLKGHFQYHLEAGLLSQVMVTLMTESMTTTASMNLQSGSRREV
                     MEVQRAEETYHLENLDELSIYKGTEKRVLGFASWDTTLHKRGFETMIDAFLEAISTGV
                     NPVSPESSLLSHWICQQIADSQLSYGELTVELPKD"
     gene            3635..4129
                     /locus_tag="VHC05_000980"
     CDS             3635..4129
                     /locus_tag="VHC05_000980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEQ5402299.1"
                     /translation="MEIRRPTLKDKDAVLSMINEFLEQKSATDGLWHFNVNDFNYETW
                     LEDSLRQEMGLSSQGVPAIQYVAFDERSQAIGFLNLRLRLNERLLEKGGHIGYSVRPS
                     QRGKGYAKEMLKQAVSCAISKNITTILVTCDETNVASRAVIVANGGVLEDSRGGTERY
                     WIEE"
     gene            4144..4758
                     /gene="nrdG"
                     /locus_tag="VHC05_000981"
     CDS             4144..4758
                     /gene="nrdG"
                     /locus_tag="VHC05_000981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HEQ5402300.1"
                     /translation="MAEKCWNNPKPKQWQAEELSQGRIIDYKAFNFVDGEGVRNSLYV
                     SGCLFHCKGCYNAATWSFKAGMPYTQELEEQIMTDLAQPYVQGLTLLGGEPFLNTGIL
                     IPLIKRIRCELPEKDIWSWTGYTWEEMMLETPDKLEMLSLIDILVDGRFDITKKNLML
                     QFRGSSNQRIIDVQKSLAAKEVIIWDKLNDGDQTFEQISREDLL"
     gene            complement(4932..5663)
                     /gene="yaaA"
                     /locus_tag="VHC05_000982"
     CDS             complement(4932..5663)
                     /gene="yaaA"
                     /locus_tag="VHC05_000982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide stress protein YaaA"
                     /protein_id="HEQ5402301.1"
                     /translation="MLTFLIPTAKEMVIPKESYPHLLPQPSQAILKAMAAMTTEDLAK
                     AYRIKEEAAKKEQQRWQDMTSQQSLAYPAYQLFNGLMYRHIKRDKLTTQEQAYLTQQV
                     YITSSFYGIIPANHPIAEHRHDFHTRIKIEGQSLKSYWRPCYNQFAKEHPQVISLLSS
                     EFDDVFSKDCKQLWIGPKFMAEKEGQFKTHSTISKKARGAFLTACMENNCQTVDSLKS
                     LVFAGFYYHPDLSTDHEFVYIKKEA"
     gene            complement(5798..6553)
                     /locus_tag="VHC05_000983"
     CDS             complement(5798..6553)
                     /locus_tag="VHC05_000983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011529092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEQ5402302.1"
                     /translation="MTYPYNSTISLGKVSLNVTDLAKMTTFYTSIIGLQVLSQDTTSR
                     QLTTDGKTVILELRQTPLPANKAYGLYHTAFLVPDRHSLGLHFLTRGISLEGAADHGY
                     SEAIYLSDPEGNGIEIYHDKAVEHWDIRDNGQIIGVTEPTDTKSILEQLTDIPKHFLL
                     AQDTRISHVHLSVKNALDSSLLYQKVFDLGDKMTIPSASWIASGNYHHHLAFNHWSAP
                     YLKKHQEGTPGLAFLTIHIETPLLFSATLKKAR"
     gene            6739..7077
                     /locus_tag="VHC05_000984"
     CDS             6739..7077
                     /locus_tag="VHC05_000984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5402303.1"
                     /translation="MLKKRPACPVETTLSVIGNKWELLILRDLLKGTLRFGQLKSSIG
                     SVSQKVLTAQLRAMEADGLVHRELYAEVPPRVEYSLTETGLSLAPVIEAMSDWDQTYQ
                     EKHADLFEEG"
     gene            complement(7356..8069)
                     /gene="treR"
                     /locus_tag="VHC05_000985"
     CDS             complement(7356..8069)
                     /gene="treR"
                     /locus_tag="VHC05_000985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trehalose operon repressor"
                     /protein_id="HEQ5402304.1"
                     /translation="MTKYERIYKDLETKINKDFYKEGDFLPTEIELSQQYQASRDTVR
                     KALSLLTKAGLILKKQGRGTQVIKHHQIMFPISELTSYQELVSYSNLDSKTNVIAIDK
                     LIVDETLSKLTGFSKNSLVWRVTRQRVVEGVASVLDIDYLSKTLVPIMTREIAEHSIY
                     QYLEKELHLAIDFALKEVTIDQITDRDKILLDLGSDQHVVSVKSKVYLSNNNQFQFTE
                     SRHKLEKFKFLDFARRRPK"
     gene            8280..10304
                     /gene="treP"
                     /locus_tag="VHC05_000986"
     CDS             8280..10304
                     /gene="treP"
                     /locus_tag="VHC05_000986"
                     /EC_number="2.7.1.201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system trehalose-specific EIIBC component"
                     /protein_id="HEQ5402305.1"
                     /translation="MGKFEQDAKSLLTAIGGKENIKAVTHCATRMRFVLNDNNKANVK
                     EIEKISVVKGTFTNAGQFQVIIGNDVPVFYNDFTAVSGIEGVSKEAAKSAAKSNQNAL
                     QRVMTMLAEIFTPIIPAIIVGGLILGFRNILESVPFEFLGQQVEKGKLVFDAAGDPVW
                     NTIVRVSPFWSGVNHFLWLPGEAIFHFLPVGITWSVTRKMGTTQILGIVLGICLVSPQ
                     LLNAYAVAGTPAAEIAKNWVWDFGFFTINRIGYQAQVIPALLAGLSLAYLEIFWRKRI
                     PEVVSMIFVPFLSLIPALILAHTVLGPIGWIIGKGISFVVLAGLTGPVKWLFGAIFGA
                     LYAPLVITGLHHMTNAIDTQLIADTATRTTGLWPMIALSNIAQGSAVFAYYLMNRHEE
                     REAEISLPAAISAYLGVTEPALFGVNVKYVYPFVAGMIGSGIAGLLSTTFNVQANSIG
                     VGGLPGFMAINVKYMIPFFICMAVAIVVPMFLTFFFRKSHIMTKTEDEAKLPETPVSE
                     APAATAPHKTMQGTVITLTSPLTGEVKALSEAVDPVFAQGVMGQGALLQPTEGVLVAP
                     CDAEVSVLFPTKHAICLVTTEGLELLMHIGMDTVNLAGQGFEALVKQGDQVKAGQTLI
                     QFDIAAISEAGYATETPLVVTNQDAFTVTVEGNLPHQIKANDKLVVAMKK"
     gene            10372..12000
                     /gene="treC"
                     /locus_tag="VHC05_000987"
     CDS             10372..12000
                     /gene="treC"
                     /locus_tag="VHC05_000987"
                     /EC_number="3.2.1.93"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="HEQ5402306.1"
                     /translation="MTIDKKKVVYQIYPKSYKDTTGNGVGDLRGIIDKLPYLQELGID
                     MIWLNPFYPSPQRDNGYDVSDYTTVNPDFGTMADFEDLVKAAKEHQIELMLDMVLNHC
                     STDHEWFQKALAGDPYYQDFFILRDQPTDWVSKFGGNAWAPFGDTGKYYLHLFDVTQA
                     DLNWRNPHVREELAKVVNFWRDKGVKGFRFDVINLIGKDEELVDCPVNDGKPAYTDRP
                     ITHTYLHDLNQASFGQDDSFMTVGEMSATTIDNCLLYTAPEREELSMAFNFHHLKVDY
                     ENGQKWTIMAFDFAALRDLFHAWGEGMSQGNGWNALFYNNHDQPRALNRFVDVTHFRN
                     EGATMLAASIHLSRGTPYIYMGEEIGMLDPDFDSMDDYVDVESLNAYSSLLVSGKSAK
                     EAFAIIKAKSRDNARTPMQWDASEHAGFTTGKPWLEVSKSYRDINVETEKEGRIFPFY
                     QRLIALRKELPIIAEGDYRAAFKDSQAVYAFERHLGDQCLLVLNHFYADEVELELPPR
                     YQHGQVLISNYEKVSICEKVILKPYQTLAILADN"
     gene            12208..14103
                     /gene="pepO"
                     /locus_tag="VHC05_000988"
     CDS             12208..14103
                     /gene="pepO"
                     /locus_tag="VHC05_000988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endopeptidase PepO"
                     /protein_id="HEQ5402307.1"
                     /translation="MTTYQDDFYQAVNGKWAETAVIPDDKPRTGGFSDLADEIEALML
                     DTTDAWLAGDHVPDDAILANFVKFHRLVADYAKRDEVGVSPILPLIEEYQSLKSFSEF
                     VANIAKYELAGLPNEFPFSVAPDFMNAQLNVLWAEAPSILLPDTTYYEEGNEKAEELR
                     GIWRQSQEKLLPQFGFSTEEIKDLLDKVIELDKQLAKYVLSREEGSEYAKLYHPYVWA
                     DFKKLAPELPLDSIFEKILGQVPDKVIVPEERFWTEFAATYYSEANWDLLKANLIVDA
                     ANAYNAYLTDDIRVESGAYSRALSGTPQAMDKQKAAFYLAQGPFSQALGLWYTGQKFS
                     PEAKADVESKVARMIEVYKSRLETADWLAPATREKAITKLNVITPHIGYPEKLPETYA
                     KKVIDESLSLVENAQNLAKITIAHTWSKWNKPVDRSEWHMPAHLVNAYYDPQQNQIVF
                     PAAILQEPFYSLDQSSSANYGGIGAVIAHEISHAFDTNGASFDEHGSLNDWWTQEDYA
                     AFKERTDKIVAQFDGLESHGAKVNGKLTVSENVADLGGVACALEAAQSEEDFSARDFF
                     INFATIWRMKAREEYMQMLASIDVHAPGELRTNVTLTNFDAFHETFDIKEGDAMWRAP
                     KDRVIIW"
     gene            complement(14269..15309)
                     /locus_tag="VHC05_000989"
     CDS             complement(14269..15309)
                     /locus_tag="VHC05_000989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003053075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Ts"
                     /protein_id="HEQ5402308.1"
                     /translation="MAEITAKLVKELREKSGAGVMDAKKALVETDGDMDKAVELLREK
                     GMAKAAKKADRVAAEGLTGVYVHGNVAAVVEVNAETDFVAKNAQFVELVNATAKVIAE
                     GKPANNDEALALVMPSGETLAEAYVNATATIGEKISFRRFALIEKTDEQHFGAYQHNG
                     GRIGVISVVEGGDDALAKQVSMHIAAMKPTVLSYTELDAQFIKDELAQLNHAIELDNE
                     SRAMVDKPALPFLKYGSKAQLSDDVITAAEADIKAELAAEGKPEKIWDKIIPGKMDRF
                     MLDNTKVDQAYTLLAQVYIMDDSKTVEAYLDSVNAKAIAFARFEVGEGIEKKANDFES
                     EVAATMAAALNN"
     gene            complement(15443..16210)
                     /gene="rpsB"
                     /locus_tag="VHC05_000990"
     CDS             complement(15443..16210)
                     /gene="rpsB"
                     /locus_tag="VHC05_000990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HEQ5402309.1"
                     /translation="MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQ
                     QTVKLADQAYEFVRDAAANDAVILFVGTKKQAAEAVADEATRAGQYFINHRWLGGTLT
                     NWGTIQKRIARLKEIKRMEEEGTFDVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDV
                     MYVVDPHKEQIAVKEAKKLGIPVVAMVDTNADPDDIDIIIPANDDAIRAVKLITAKLA
                     DAIIEGRQGEDADVAFEADTQADSIEEIVEVVEGDNA"
     gene            16514..19588
                     /locus_tag="VHC05_000991"
     CDS             16514..19588
                     /locus_tag="VHC05_000991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HEQ5402310.1"
                     /translation="MTKGIRFQLLGSPHIFLDNKEQFFAFAKANALLYYLVVNGSVSR
                     EVAASLLWENKNTQTAKKNLRNAIYQVNKVLQADVIICPNRNLLVLNKTLDIKTDINL
                     FLADPLAHLELYQGEFLQGFYLKSGEEFDLWVSKMRMQYEQVYLKACYQKIEEKLSLD
                     AIEDVEEHLKQLIERDEFEEKNYQLLMRLYQQGNCPGKVIETYYQLANVLDKELGIQP
                     SLQSQQIYQEVVAKDRNERKIKHFLRNSNHFLGRIDEIKQLENYFANCLACQEVGALL
                     LIGDTGIGKRTLARQVLANQTQTFQIVTAKCFREEAMDSLLPWRNILDGLGDLVIQNR
                     LLTTKAWKAALKRCFPVATIFQEDNNQPFIKDHTSLLVSFIVDILQHLAEIKALVILI
                     EDCHWMDEDSLTLLQRVMNQLVHYPIAFVLTKHLGTTPELGLCLNALMSQGRLESICL
                     EPFNRQESLAYINSQLGSQPVTEEEMEHLYQASQGNPFFLSEYTHALLRHEKFVPLTP
                     AIKAKLGLKLANLSSRDDALLNYLSCCRRPIPLNTLAQLMLLPLEEVIEMVDNLGHYY
                     ILVEESVGEEVLISFRQRIIQLYSYDRLSLSKRRLLHGQIAKRLEDLLPILTPSPHLL
                     DDIAYHYQESRQVIKALEYNLNYLDATLPFQHELFPIYSKSIGSLEKSDRDHQRLMEE
                     QFDKIRQSIADLELTYDNNRDFQQLLIRFSYLEGRYDIRTGRYQEGIKHIQKVIALAT
                     ELKQPSFLLEGYRQLIHYCIQVENKPEMRYYTSLSLEAAVAANHFEAIAISLRLNGLY
                     HLIIGELNEAERLLQQSIDFFKVTPGLQANYAIQIAAALDYLGEIAQIRYQFEKAVAY
                     QKQAIALTENKPAELSVSIFYIGLGISYFYLADFEQAEQILSLAKEALVNHSYPWKET
                     QLEIYLAMIQWKKGNYQPALTLLDYRETLMSRYRNPRDKGLVFYLMAVVKYQLIRQGA
                     TLSQQEKEMADHLLSESFEYYYEIASTNLNPYRDCHLVSELNDLRQQLSAKS"
     gene            complement(19619..20605)
                     /locus_tag="VHC05_000992"
     CDS             complement(19619..20605)
                     /locus_tag="VHC05_000992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginase family protein"
                     /protein_id="HEQ5402311.1"
                     /translation="MLEDYYPSTTSYYHSGIDDDLYTAKWGMVMTFLDLNDSSLTPFE
                     GTHFALIGFKSDKGVYINNGRVGAVESPAAIRTQLAKFPWHLGNQVMVYDVGNIDGPN
                     RSLEQLQNSLSKAIKRMCDLNLKPIVLGGGHETAYGHYLGLRQSLSSSDDLAVINMDA
                     HFDLRPYDQTGPNSGTGFRQMFDDAVADKRLFKYFVLGIQEHNNNLFLFDFVAKSKGI
                     QFLTGQDIYQMGHQKVCRAIDRFLEGQERVYLTIDMDCFSVGAAPGVSAIQSLGVDPN
                     LAVLVLQHIAASGKLVGFDVVEVSPPHDIDNHTANLAATFIFYLVQIMAQHN"
     gene            complement(20792..22333)
                     /gene="hutH"
                     /locus_tag="VHC05_000993"
     CDS             complement(20792..22333)
                     /gene="hutH"
                     /locus_tag="VHC05_000993"
                     /EC_number="4.3.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine ammonia-lyase"
                     /protein_id="HEQ5402312.1"
                     /translation="MTRVINLDGESLTIEDVIAIARQGIACRIDDSAIEAVNASRKIV
                     DDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIM
                     LIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLG
                     LGKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLK
                     LSDLAGALSLEVHNGITSPFEENLHTIRPQSGQLATARNIRNLIEGSQNTTVATQSRV
                     QDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDGHVISGGNFHGEPMA
                     QPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLAS
                     ENKVLAHPASVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQALDL
                     KSENHELGKGTKVAYDLFRKEVNFIEHDKHIEIYDELNKASTVIEDPSFLEAVEQAVE
                     LSIQF"
     gene            complement(22344..23687)
                     /locus_tag="VHC05_000994"
     CDS             complement(22344..23687)
                     /locus_tag="VHC05_000994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="APC family permease"
                     /protein_id="HEQ5402313.1"
                     /translation="MASNHMNEQEREQAKFSLSGATLYGINAVIGSGIFLLPRAIYKG
                     LGPASIAVMFGTAILTIMLAVCFAEVSGYFGKNGGAFQYSKRAFGDFIGFNVGFLGWT
                     VTIFAWAAMAAGFARMFIITFPAFEGWHIPLSIGLIILLSLMNIAGLKTSKIVTITAT
                     IAKLIPIVAFCACTLFFIKNGLPNFTPFVQLEPGTNLLGAISNTAVYIFYGFIGFETL
                     SIVAGEMRDPEKNVPRALLGSISIVSVLYMLIIGGTIAMLGSQIMMTNAPVQDAFVKM
                     IGPAGAWMVSIGALISITGLNIGESIMVPRYGAAIADEGLLPAAIAKQNQNGAPLVAI
                     LVSGAIAIVLLLTGSFENLAKLSVIFRFFQYIPTALAVMKLRKDDPDANVIFRVPFGP
                     IIPILAVIVSLVMIWGDNPMNFVYGAVGVIIASSVYYLMHGRNHQMDQMPPKEQI"
     gene            complement(23907..24503)
                     /locus_tag="VHC05_000995"
     CDS             complement(23907..24503)
                     /locus_tag="VHC05_000995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HutD family protein"
                     /protein_id="HEQ5402314.1"
                     /translation="MTKVTIKAPSDYLQTDWSGGETNQLFLYPEDGDYKKREFSYRLS
                     KSTVALRQTTFTLLDGYHRILMTLDKPITLSDLSHAKEISLTPFEPYAFEGDTRIVSR
                     GICQDMNLMYDDQYQGQLLPVWSDTLFEAPKADCQLLYALSKLTYSVTNQANQELEAN
                     HLLVIEQEASLSDLKVCLNQTSPAQTPVAVWAGLWYKT"
     gene            complement(24525..26198)
                     /locus_tag="VHC05_000996"
     CDS             complement(24525..26198)
                     /locus_tag="VHC05_000996"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HEQ5402315.1"
                     /translation="MVLSDIEIANSVSMEPISKVADQLGIDKEALCLYGKYKAKINAR
                     QLVALKDKPDGKLILVTAISPTPAGEGKTTTSVGLVDALSAIGKKAVIALREPSLGPV
                     FGVKGGAAGGGHAQVVPMEDINLHFTGDFHAIGVANNLLAALIDNHIHHGNSLGIDSR
                     RITWKRVVDMNDRQLRHIVDGLQGKVNGVPREDGYDITVASEIMAILCLSENISDLKA
                     RLEKIIIGYNYQGEPVTAKDLKAGGALAALLKDAIHPNLVQTLEHTPALIHGGPFANI
                     AHGCNSVLATKLALKYGDYAVTEAGFGADLGAEKFIDIKCRMSGLRPAAVVLVATIRA
                     LKMHGGVQKTDLATENVQAVVDGLPNLDKHLANIQDVYGLPVVVAINKFPLDTDAELQ
                     AVYDACNKRGVDVVISDVWANGGAGGRELAEKVVTLAEQDNQFRFVYEEDDSIETKLT
                     KIVTKVYGGKGITLSPAAKRELADLERLGFGNYPICMAKTQYSFSDDAKTLGAPTDFT
                     VTISNLKVSAGAGFIVALTGAIMTMPGLPKVPASETIDIDEEGNITGLF"
     gene            complement(26216..26842)
                     /locus_tag="VHC05_000997"
     CDS             complement(26216..26842)
                     /locus_tag="VHC05_000997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclodeaminase/cyclohydrolase family protein"
                     /protein_id="HEQ5402316.1"
                     /translation="MGLVDLSLTDFAKVLGSDAPDPGGGSAAALSGANGISLTKMVCE
                     LTLGKKKYADYQDIITEVHAKSTALQASLLAAIDKDTEAFNLVSAVFDMPKETDEDKA
                     ARRTAMQKALKTAAQSPFEMMTLMVEALEITATAVGKSNTNAASDLGVAALNLKAGLQ
                     GAWLNVLINLSGIKDEDFVTDYRQKGQALLDKGCHLADDIYTKILDIV"
     gene            complement(26853..27752)
                     /gene="ftcD"
                     /locus_tag="VHC05_000998"
     CDS             complement(26853..27752)
                     /gene="ftcD"
                     /locus_tag="VHC05_000998"
                     /EC_number="2.1.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003005485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate formimidoyltransferase"
                     /protein_id="HEQ5402317.1"
                     /translation="MAKIVECIPNFSEGQNQAVIDGLVATAKSIPGVTLLDYSSDASH
                     NRSVFTLVGDDQSIQEAAFQLVKYASENIDMTKHHGEHPRMGATDVCPFVPIKDITTQ
                     ECVEISKQVAERINRELGIPIFLYEDSATRPERQNLAKVRKGQFEGMPEKLLEEDWAP
                     DYGDRKIHPTAGVTAVGARMPLVAFNVNLDTDNIDIAHKIAKIIRGSGGGYKYCKAIG
                     VMLEDRHIAQVSMNMVNFEKCSLYRTFETIKFEARRYGVNVIGSEVIGLAPAKALIDV
                     AEYYLQVEDFDYHKQVLENHLLG"
     gene            complement(27840..29870)
                     /locus_tag="VHC05_000999"
     CDS             complement(27840..29870)
                     /locus_tag="VHC05_000999"
                     /EC_number="4.2.1.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="urocanate hydratase"
                     /protein_id="HEQ5402318.1"
                     /translation="MSFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQA
                     QTEIALKNALRYVPTKFHEEVIPEFLEELKTRGRIYGYRFRPKDRIYGKPIDEYKGNC
                     TAAKAMQVMIDNNLSFEIALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLV
                     VESGHPVGLFKSKPEAPRVIITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYI
                     GPQGIVHGTFNTLLNAGRLKLGVADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAI
                     IAEVDQSRIETRHSQGWVSQIAESPEEALQLAQKAIDAKESTSIAYHGNIVDLLEYVN
                     DKQIHVDLLSDQTSCHNIYDGGYCPAGISFDERTRLLAEDKDTFHQMVDDTLARHFEA
                     IKTLTENGTYFFDYGNAFMKSVYDSGITEISKNGRNDKDGFIWPSYVEDIMGPMLFDY
                     GYGPFRWVCLSGKHEDLVATDKAAMEAIDPDRRYQDRDNYNWIRDAEKNQLVVGTQAR
                     ILYQDCIGRVTIALKFNELVRKGKIGPVMIGRDHHDVSGTDSPFRETSNIKDGSNVTC
                     DMAVQCYAGNAARGMSLVALHNGGGTGIGKAINGGFGLVLDGSERIDEIIKSAIAWDT
                     MGGVARRNWARNEHAIETAIEYNRLHAGTDHITIPYLADDDLVISAVDQLFH"
     gene            30162..31427
                     /locus_tag="VHC05_001000"
     CDS             30162..31427
                     /locus_tag="VHC05_001000"
                     /EC_number="3.5.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazolonepropionase"
                     /protein_id="HEQ5402319.1"
                     /translation="MVADVLLTHFNQLFCLNDPGHPLTGQEMKKATIVEDGYIAIKDS
                     LIVALGSGEPDAELVGPQTIMRSYKGKIATPGIIDCHTHLVYGGSREHEFAKKLAGVS
                     YLDILAQGGGILSTVRATRSASFDNLYQKSKRLLDYMLLHGVTTVEAKSGYGLDWETE
                     KRQLDVVAALEKDHPIDLVSTFMAAHAIPEEYKGNPKAYLDVIIKDMLPVVKEENLAE
                     FCDIFCEKNVFTADESRYLLSKAKEMGFKLRIHADEIASIGGVDVAAELSAVSAEHLM
                     MITDDGIAKLIGAGVIGNLLPATTFSLMEDTYAPARKMIDAGMAITLSTDSNPGSCPT
                     ANMQFVMQLGCFMLRLTPIEVLNAVTINAAYSVNRQERVGSLTVGKEADIAIFDAPNI
                     DYPFYFFATNLIHQVYKKGQLTVDRGRIL"
     gene            complement(31485..33017)
                     /gene="ahpF"
                     /locus_tag="VHC05_001001"
     CDS             complement(31485..33017)
                     /gene="ahpF"
                     /locus_tag="VHC05_001001"
                     /EC_number="1.8.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkyl hydroperoxide reductase subunit F"
                     /protein_id="HEQ5402320.1"
                     /translation="MALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEI
                     AAMSERISIENITLDRQPSFKVAKKGHGSGVVFAGLPLGHELTSFILALLQVSGRAPK
                     VDQDVIDRIKAIDRPLHFETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQD
                     EVKAKGIMSVPTVFLDGEEFTSGRATIEQLLEQIAGPLSEEAFADKGLYDVLVIGGGP
                     AGNSAAIYAARKGLKTGLLAETFGGQVMETVGIENMIGTLYTEGPKLMAEVEAHTKSY
                     DVDIIKAQLATSIEKKENIEVTLANGAVLQAKTAILALGAKWRNINVPGEDEFRNKGV
                     TYCPHCDGPLFEGKDVAVIGGGNSGLEAALDLAGLAKHVYVLEFLPELKADKVLQDRA
                     AKTNNMTIIKNVSTKDIVGEDHVTGLNYTERDSGEDKHLDLEGVFVQIGLVPNTAWLK
                     DSGVNLTDRGEIIVDKHGSTNIPGIFAAGDCTDSAYKQIIISMGSGATAAIGAFDYLI
                     RQ"
     gene            complement(33038..33598)
                     /gene="ahpC"
                     /locus_tag="VHC05_001002"
     CDS             complement(33038..33598)
                     /gene="ahpC"
                     /locus_tag="VHC05_001002"
                     /EC_number="1.11.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002273221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxiredoxin"
                     /protein_id="HEQ5402321.1"
                     /translation="MSLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFS
                     FVCPTELGDLQKQYETLKSLGVEVYSVSTDTHFVHKAWHDDSDVVGTITYPMIGDPSH
                     LISQAFEVLGEDGLAQRGTFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKH
                     PGEVCPAKWKEGAETLTPSLDLVGKI"
BASE COUNT         9664 a         6520 c         7576 g        10019 t
ORIGIN      
        1 aacgacaaaa agttttattg tttatcagaa aaagtaatct aatatcaata tattgtgttc
       61 gagcaaaaaa cttgacacaa tatattgatt tttttagttg tcgtgatata atagttccgt
      121 aaggagattt gatatggtaa gtttagaaga agacaaggtg actgttcaac ctgatattaa
      181 agtgattaaa cgagatggtc gccttgttaa ttttgatagt acaaaaatct atagtgcttt
      241 attaaaagca agcatgaaag taactcggat gtcgccactt gttgaggcta aattagaggc
      301 tatttctgat cgcattatag cagaaattat tgagcgtttt ccaactaata tcaaaattta
      361 tgaaatccaa aatattgtag agcataagct tcttgcagct aatgaatatg ctattgcaaa
      421 agaatacatt aattatcgta ctcagcgtga ctttgcacgt tcacaagcaa cagatatcaa
      481 tttttctatt gataaattaa ttaataaaga tcaaacagtt gttaatgaaa atgctaacaa
      541 agatagcgat gtttttaata ctcaacgaga tttaactgct ggaatcgtag ggaaatcgat
      601 tggtttaaaa atgttacctt cgcatgttgc taatgctcat caaaaaggag atatccatta
      661 ccatgatttg gattacagtc cttatacacc gatgacgaac tgctgtttaa ttgactttaa
      721 gggcatgtta gccaatggct ttaaaattgg taatgctgaa gtggaaagtc ccaagtctat
      781 tcaaactgca acagctcaga tctcacagat tattgcgaat gtagcatcaa gtcagtacgg
      841 cggatgcaca gctgatcgca ttgacgagtt tttagcccca tatgcggagc ttaactttaa
      901 aaaacatatg gctgatgcta agaaatggat cgttgagact aagagagaaa gctatgcttt
      961 tgaaaagact caaaaagata tttatgatgc gatgcagtct ttggagtatg aaattaatac
     1021 gctctttacg tctaatggtc aaacaccatt tacttcttta ggatttggtt tggggacgtc
     1081 ttggtttgaa cgtgagattc aaaaagctat tttgaccatt cggattaatg gtcttggtag
     1141 tgaacatcgc acggctattt tccctaaatt aattttcacg gttaaacgtg gcttgaattt
     1201 agaaccagat tcaccaaact atgatattaa gactttggct ttagaatgtg cgactaagcg
     1261 gatgtacccg gatatgttat cttatgataa aattattgat ttgacaggat ctttcaaatc
     1321 tccaatggga tgccgctctt tccttcaagg ctggaaagat gaaaatgggc aagatgtgac
     1381 ctcaggccgt atgaatcttg gggttgtcac cctcaattta cctcgcattg ccatggaatc
     1441 aaatggcgat atggataagt tttgggagct gtttaatgag aggatgctaa ttagtaagga
     1501 tgctttaatt tatcgtgtcg aacgtgtcac agaagcaaaa ccagcaaatg cccctattct
     1561 ttatcaatat ggtgcttttg gaaagcgttt ggagaagaca gggaatgtaa atgatctctt
     1621 taagaatcgt cgtgcaacag tctctcttgg ctatattggt ctttatgaag tggcgtctgt
     1681 tttttatggt ggtcaatggg aaggtaatcc agatgctaaa gcttttacct tgtcaattgt
     1741 caaggcaatg aaacaggcct gtgaggattg gtcagatgga tatggttatc atttctctgt
     1801 ttattcgact ccatcagaaa gtttgacaga tcgcttttgt cgtttagata cggaaaaatt
     1861 tggcattgtg acagatatta cggataaaga atactataca aattcttttc actatgatgt
     1921 gcgtaagagt ccgacacctt ttgaaaaatt agattttgaa aaagattatc cagaagcagg
     1981 tgcttcaggt ggttttatcc actactgtga gtatcctgtt ttgcaacaaa atccaaaggc
     2041 cttggaagcg gtttgggact atgcttatga tcgtgtgggg tatttgggaa ccaatacgcc
     2101 tattgataaa tgctataatt gccaatttga aggcgatttt accccaacag aacgtggttt
     2161 tacttgccca aactgtggca ataatgaccc taaaacagtt gatgtggtca aacgtacatg
     2221 tggttacttg gggaatcctc aggcccgccc aatggttaac ggtcgccata aggaaatctc
     2281 tgcgcgtgta aaacatatga atggttctac tataaaatac ccaggcctgt aaactcaagc
     2341 tgggggagag cccttttgat ggaaatatga tatgcttaaa aggttgcttc atgcaagcaa
     2401 tcttttattg tttaatggtt tcttagcaat tgtgagataa gaataactaa tccaaaacga
     2461 ctaattagct gttagagcaa tcggactata agaagaaaga gataaggaag aaataatggg
     2521 aaaatatcaa ttagactata aaggaatgca gcaggtagaa cgctttcatg agaagcattc
     2581 taaaaaaaag acggataaaa aatcccgcct tcaagaactt aaggctcggt ttttagagaa
     2641 gtcaaaaaaa caggataact aaagtatcca gtaaagaaag aaggttgagt atgcttaata
     2701 ttgggattgt gggactaggt gctatttcac aaaaagccta tttaccatat atgagacagc
     2761 tgagtgacat tacttggcat ctatcaacgc ggaatgcagc agtacgtcag caggtcggtc
     2821 agttatttgg tcacgctatt ctttacagtg atgtcaagga gttgtcaaaa acaaacttag
     2881 atgggatctt tattcatgcg gccacatcgg cccacgcaga gttggctagt ttatttttaa
     2941 atcaggggat cccagtcttt atggataaac ctatagctga caattacctg atgacaaaga
     3001 acctctatga cttagccaaa gaaaatcaga cttttctgat ggcaggattt aacaggcgtt
     3061 ttacacctcg tgtcaagaag ttgtcaagtt tgtcaactaa gcgtaaagtg gctgttgaaa
     3121 aaaatgactt gaaccggcca ggagatatgg cttttaagct ctttgatttc tttatccatc
     3181 ctttagatac agccttattc ttgacagaag ggaccttact aaaagggcat tttcaatatc
     3241 atctggaagc aggcttactg agtcaagtta tggtaaccct gatgaccgaa agcatgacga
     3301 ctacagcttc tatgaattta caatcaggga gtcgccgtga ggtaatggaa gttcaacggg
     3361 ctgaagaaac ttatcattta gagaacttag acgagttatc tatttataaa ggtactgaaa
     3421 aaagggtgct tggctttgct tcttgggaca ctaccttgca caaaagaggt tttgaaacaa
     3481 tgatcgatgc ctttttagaa gctattagca caggcgtcaa tcctgtcagc cctgagtcta
     3541 gtcttttaag ccactggatt tgtcaacaga ttgctgactc tcagctttct tatggagagt
     3601 taacggtaga gttgcctaag gattaggaat tgatatggaa ataagacgac cgactttaaa
     3661 agataaagat gctgtattgt caatgattaa cgaattttta gagcagaaaa gtgctacaga
     3721 tgggttatgg cattttaacg tcaatgactt caactatgaa acatggttgg aagattcctt
     3781 gcgacaggaa atgggtttgt ccagtcaagg agtgcctgct attcaatacg tcgcatttga
     3841 tgagagaagt caggctatcg ggttcttaaa tcttcgttta cggttaaatg agagattact
     3901 tgaaaaaggt gggcatattg gttactctgt ccgtcccagc cagcgtggga aaggttatgc
     3961 caaggagatg cttaaacaag ctgtcagctg tgcgatttcc aagaatatca cgacaatttt
     4021 ggtaacttgt gatgagacta atgttgcaag ccgagcagtt attgtggcta acggcggtgt
     4081 cttggaagat agtcgaggtg gaacggaacg ttattggatt gaagaataaa gaggcgataa
     4141 gtgatggcag aaaagtgttg gaataatcct aagccaaagc aatggcaggc agaggagtta
     4201 agtcaaggcc ggattattga ctataaggct tttaactttg ttgatggtga aggggttcgt
     4261 aattcccttt atgtgtctgg ttgtttattc cattgcaagg ggtgttataa tgctgcgact
     4321 tggtctttta aggcgggaat gccttatacg caagaacttg aagagcagat aatgacggat
     4381 ttggcacagc cttatgttca gggactgaca cttttaggtg gagaaccctt tttgaatacg
     4441 ggtatcttaa ttcctctgat taagcgtatt cggtgtgaat tgccagaaaa agatatttgg
     4501 tcttggacgg gttatacttg ggaagaaatg atgcttgaaa caccagacaa actggaaatg
     4561 ctgtccttaa ttgatattct ggtagatggt cgttttgata tcacaaaaaa gaacctcatg
     4621 ttgcaattta gaggctcttc taaccagcga attatcgatg ttcaaaagtc tttggctgct
     4681 aaagaagtga ttatctggga taagttaaac gatggggacc aaacctttga acaaattagt
     4741 cgggaggatt tgctttaaga agctgactta tccacatgat ttttttgaaa aggtcatgtg
     4801 aaaacaggtc ccttaagggt gaattgggga gaaagtaatt gttattccct ggttttcccc
     4861 acattatcct catagttatc cacaggttgt gtataagttg tagaattgtg aataaagact
     4921 aaaaaagagg cctaggcctc ttttttgata tagacaaatt catgatctgt tgataggtct
     4981 ggatggtagt aaaaaccagc aaagacaagg cttttaaggc tgtcaacagt ttggcaatta
     5041 ttttccatac aggcagtaag aaatgcacct cgtgcctttt ttgaaatggt ggaatgggtt
     5101 ttgaattggc cctctttttc tgccataaac ttgggaccta tccacaattg tttacagtct
     5161 ttggaaaaga catcgtcaaa ttcactggat aaaagggaaa tcacttgggg atgctctttg
     5221 gcaaactgat tataacaggg ccgccagtaa gacttgaggc tttgtccttc aatttttatt
     5281 ctggtgtgaa aatcatggcg gtgttctgcg ataggatgat tagcgggaat gataccgtaa
     5341 aaggatgagg tgatgtaaac ctgctgggtg aggtaagcct gttcttgggt agtgagctta
     5401 tcgcgcttga tatggcggta cataaggcca ttgaacagtt ggtaggcagg gtaagccaag
     5461 ctttgttgag aggtcatgtc ttgccagcgt tgctgttctt ttttagctgc ctcttctttg
     5521 atacgatagg ctttggccaa gtcctctgtg gtcatagctg ccattgcctt taaaatggcc
     5581 tggcttggtt ggggcagtag gtgtggataa gattctttag gaatcaccat ttcttttgcg
     5641 gttggaatta aaaaggttag catagtgtta ttgtagtaaa gttacttgct ttctgtcaag
     5701 aaaactagtc ttgtccaagg atgacgttca aacggctacc ttcctcgtct tctgtcgtga
     5761 aagaagaaga atcttcttgt aaaatagcta ggccatatca tctggctttt ttgagagtgg
     5821 ctgaaaaaag caggggcgtc tcaatgtgaa tggttaagaa ggctagacct ggagtgcctt
     5881 cttggtgttt tttgaggtaa ggggctgacc agtgattgaa tgcaaggtga tgatggtagt
     5941 tccctgaagc aatccagcta gcacttggaa tggtcatttt atcgcctaaa tcaaaaacct
     6001 tttgatagag aagtgaagaa tccagagcat ttttgacact cagatggaca tgactaatgc
     6061 gtgtgtcttg agctagtaaa aagtgcttgg ggatatctgt caactgctcc aatatgcttt
     6121 tggtatccgt gggctcagtc acaccaataa tttgaccatt gtcgcggata tcccaatgct
     6181 caacagcttt gtcatgatag atttcaatcc cattaccctc aggatcgctg aggtagatag
     6241 cttcgctata gccgtgatca gctgctcctt ctaaagagat acctctggtt aagaaatgaa
     6301 gtcccaagct atgacgatca ggaactaaaa aggctgtgtg ataaagacca taagccttat
     6361 ttgctggtaa aggtgtttgt cgtaactcta agataacggt tttaccgtct gtagtcaatt
     6421 gacgagatgt cgtgtcttgt gagagaacct gtaaaccgat aatacttgtg taaaaggttg
     6481 tcatctttgc tagatcggta acattgaggg aaacctttcc tagagagatg gttgagttgt
     6541 aagggtatgt catcctattg tctccaaaag tgattaagcc tatgataact tattagtttc
     6601 aaaaagaaaa gtaggcacaa ataagtggta taggcactaa aaagtaactc atttgtcagc
     6661 cctatcttgt ttctgttctc tctaatagtc tataatgggt tataagttac aaaaagatac
     6721 taagaggagc tgctgcctat gctgaaaaaa agaccggctt gtcccgtaga aacaacctta
     6781 tcggtaatcg ggaataaatg ggaattatta atattaaggg acttgctaaa ggggaccttg
     6841 cgttttgggc agttgaagtc ctcaataggt tcggtcagtc aaaaggtact tactgcccaa
     6901 ttaagggcta tggaagcaga cggattggtt catcgggaat tgtatgcaga agtgccacct
     6961 cgggtggagt attccttaac agaaactggg ttgagcttag ctcctgttat tgaagcgatg
     7021 tcggattggg accaaactta ccaagaaaaa catgccgatt tatttgaaga aggctagagg
     7081 aaagagttgt ccgagcatac tgagacttag agaagctgag agttttttta aaatgatatt
     7141 atcaaattct ttacagtttg ataaaattac tttttttcta caaaaagact tgcgctcatc
     7201 tcacgaatat gataatataa tatcaagtct gtttgagaaa acagaagctc aggtcaagta
     7261 agtgcacact tacaataaca cagttgataa tggggaaact cagagtcaag aaaaagaaaa
     7321 gcaagccttg cattttgcaa ggcttttttc tgtctttatt ttggtctgcg ccgagcaaaa
     7381 tctaaaaatt taaatttttc cagtttatgg cgactctcgg tgaattggaa ttggttatta
     7441 ttggaaaggt aaactttgga tttgacggaa acaacatgtt ggtctgatcc aaggtcaagt
     7501 aaaattttat cacgatcggt tatttggtca atggtaacct ctttgagggc aaagtcaatg
     7561 gcgagatgga gttccttttc caaatattga taaatagaat gctctgcgat ttcccttgtc
     7621 attattggca ccaaagtttt actaaggtaa tcaatgtcta agacggaagc cacaccctca
     7681 acaacgcgtt ggcgcgtaac acgccagacc aagctgtttt tgctaaaacc ggtcaatttt
     7741 gaaagtgtct catccacaat cagtttatca atggcaatga cgttggtctt agaatctaga
     7801 tttgagtaag agacgagttc ctgataacta gttagttctg agatagggaa catgatctga
     7861 tgatgtttaa tcacttgggt gccacgtcct tgttttttga ggataagacc tgcctttgtg
     7921 agaagtgaga gagccttgcg gacggtatct cggctagctt ggtattgttg actcaattct
     7981 atttcagtag gtaaaaaatc cccttctttg taaaagtctt tgtttatttt tgtttcgagg
     8041 tctttataaa tacgttcata ctttgtcata gggtaaatta cctttccact tgtctatttt
     8101 tttacagaca acacctttta ttttaccaaa ataatggctt ttttggcaca aacaacttgc
     8161 agacaaattt gcaatcgatt acaataaagg tgtcaatcag gttctatcta agaatttgaa
     8221 tatttcattt tgacgttgct tgttaaaagc aactagaaca aaggactagg ggatgtcaca
     8281 tgggaaaatt tgaacaggat gctaaaagtc ttctaactgc tattggcggt aaagaaaaca
     8341 tcaaggctgt cacacactgt gcaacgcgta tgcgttttgt tttgaatgat aataataagg
     8401 caaatgtcaa agagattgaa aaaatctctg tagttaaagg gacatttacc aatgctgggc
     8461 agtttcaggt aatcattggt aatgatgttc cagtttttta taatgacttt acagctgttt
     8521 ctggtattga aggggtgtct aaagaagctg ccaaatcagc agctaaaagt aatcaaaatg
     8581 ccttacaacg ggtgatgacc atgttggctg agattttcac acctattatt ccggcgatta
     8641 ttgttggggg gcttatttta ggtttccgta atattttgga gagtgtgcct tttgaatttc
     8701 ttgggcagca ggtcgaaaaa gggaaattag tttttgatgc agctggggat cctgtttgga
     8761 atacgattgt gagggtatct cctttctggt caggggttaa ccatttcttg tggttaccag
     8821 gggaagctat tttccacttc ttaccagttg ggattacttg gtctgtgacg cgtaagatgg
     8881 gaaccactca aattttaggg attgtccttg gtatctgttt ggtgtcacca caattattga
     8941 atgcctatgc ggtagcagga acgcctgctg ctgagattgc caaaaactgg gtttgggatt
     9001 ttggtttctt taccattaat cgtattgggt atcaggcaca ggttattcca gcccttttag
     9061 ctggtctgtc ccttgcttat cttgaaattt tctggcgtaa acggattcca gaagtggttt
     9121 caatgatttt tgtgccattc ctttctttga ttccagcttt gattttagcg catacggtat
     9181 tggggccaat cggttggatt attggtaaag ggatttcctt tgttgtgtta gctggattga
     9241 ctggtcctgt taaatggcta ttcggtgcta tctttggtgc cttgtatgct ccgctagtta
     9301 ttactggttt acatcacatg acaaatgcca ttgataccca attaattgct gatactgcaa
     9361 ctcgtacaac tggtttgtgg ccaatgattg ctctttcaaa tatcgctcaa gggtcagccg
     9421 tttttgctta ctatttaatg aatcgtcatg aagaacgtga ggctgaaata tcgcttcctg
     9481 cagcaatttc tgcttacctt ggggtaactg agcctgcctt atttggggtt aatgttaaat
     9541 acgtttatcc ctttgtagcc ggaatgattg gctcaggtat tgcgggtctc ttatcaacaa
     9601 cctttaatgt tcaggcaaat tctattggtg ttggtggctt accaggtttc atggctatca
     9661 atgtgaagta catgattcca ttcttcatct gtatggcagt agccattgtg gtaccgatgt
     9721 ttttaacctt ctttttccgt aaatcacata tcatgactaa gacagaagat gaggctaaac
     9781 tacctgagac acccgtttcg gaggctcctg cagcaactgc tccacataag actatgcaag
     9841 ggacagttat cactttaaca agccctttaa cgggtgaagt taaagcgttg tctgaagctg
     9901 ttgatcctgt ctttgcacag ggagttatgg gtcaaggtgc tcttcttcaa ccgacagaag
     9961 gggtgttagt agcgccttgt gatgctgaag tatcggtctt gttcccaact aaacacgcta
    10021 tttgtttggt gacgactgaa ggtttggaat tattgatgca tattggcatg gatacggtta
    10081 acttagctgg tcaaggattt gaagctttgg tgaagcaagg tgatcaggtt aaggctggac
    10141 aaacattgat tcaatttgat atagcagcta tttctgaagc tggatacgcc actgaaacgc
    10201 ctcttgtggt gactaatcaa gatgctttta cggtaactgt tgaaggtaac ttaccgcatc
    10261 agattaaggc taatgataag ttagtagtag cgatgaaaaa gtaggtttac tagggagaaa
    10321 acgttcagga actgagatca gttcctgaaa ctattttagg gaggaaaact catgacaatt
    10381 gataaaaaga aagtcgtcta tcaaatttac ccaaaatcct ataaggacac tactggaaat
    10441 ggtgtgggag acttgcgagg gatcattgat aaattgcctt acttacaaga actaggaata
    10501 gatatgattt ggttgaaccc tttctaccct agtccacaac gagacaatgg ctatgatgtt
    10561 tcagattata cgacggtcaa ccctgatttt gggacgatgg ctgattttga agatttggta
    10621 aaagctgcta aggagcatca gattgagtta atgttggata tggttttgaa tcactgttcc
    10681 acagaccacg agtggttcca aaaagcttta gcaggagacc cttattatca ggatttcttt
    10741 atcttgagag atcagccgac tgattgggtt tccaaatttg gtgggaatgc ttgggcgcct
    10801 tttggagata caggcaagta ctacttacac ttgtttgatg tgacacaggc tgacttgaat
    10861 tggcggaacc cacatgttcg tgaggaattg gctaaagtgg ttaatttttg gcgagataaa
    10921 ggagtgaagg ggttccggtt tgatgtgatt aatctgattg ggaaagatga agagctggtg
    10981 gattgtccgg tcaatgatgg taagccagcc tatacggatc gtcctattac tcacacttat
    11041 cttcatgatc tcaatcaagc cagttttggt caggatgatt cgtttatgac agtaggggaa
    11101 atgtctgcca cgactattga caactgtctt ttatacacgg ctcccgaacg tgaggagcta
    11161 tccatggctt ttaatttcca ccatctaaaa gttgattatg agaacggtca gaaatggact
    11221 attatggctt ttgattttgc agcgctgcga gacttattcc atgcttgggg tgaaggcatg
    11281 agtcaaggca atgggtggaa tgccttgttc tacaataacc atgatcaacc acgtgccctg
    11341 aatcgttttg ttgatgtaac acatttccga aacgaaggtg cgacgatgtt agcggcttcc
    11401 atccatttgt cacgaggaac gccttacatt tatatgggtg aggagattgg catgcttgat
    11461 ccagactttg atagtatgga tgattatgtg gatgtggaaa gtctcaatgc ttactcaagc
    11521 ttattagtct caggtaaaag tgcgaaagaa gcctttgcca ttatcaaggc taagtcaagg
    11581 gacaatgcca gaacaccaat gcaatgggat gctagtgaac atgctggctt tacgactggt
    11641 aagccttggt tagaggttag caaatcttat cgagacatca atgtcgaaac agaaaaagag
    11701 ggacgtattt ttcctttcta ccaacgcttg attgctttgc ggaaggaact gcctattatt
    11761 gctgaagggg actatcgggc tgcttttaaa gatagtcagg ctgtctatgc ctttgaacgc
    11821 catttaggtg accagtgttt gcttgttctc aatcatttct atgctgatga ggtcgaactg
    11881 gaattacctc cacgttatca acatggacag gtcttaatca gcaactatga gaaagtctct
    11941 atttgtgaaa aagtgatact gaaaccttat cagacacttg ctatcttagc tgataactaa
    12001 ctaaaagcct gaggttaggc ctcaggcttt tggtgattgt cacgaaaaaa gaagttttct
    12061 catatattta tttttaaact cttatttttt ctaaataaaa acaattgaga taagttattt
    12121 taaccaaatt ttggtacaat ggaaaagatt ataagtagag tttaagataa agattctaca
    12181 aatttaaaat gatataagga gatacgaatg acaacttatc aagatgattt ttaccaggct
    12241 gtgaatggga agtgggctga aacagcagtt attcccgatg acaagcctcg aacaggtgga
    12301 ttttcagact tagcagatga aattgaggca ttaatgctag acactacaga tgcttggtta
    12361 gcaggggatc atgtccctga tgatgcaatt ttagcaaact ttgttaaatt tcaccgtttg
    12421 gtggctgact acgctaaacg tgatgaagtt ggagtaagtc caattctccc tttaattgaa
    12481 gaatatcagt ccttaaaatc tttttcagaa tttgttgcta atatagcgaa atatgaattg
    12541 gcaggtttac caaatgaatt tccctttagt gtggcaccag attttatgaa tgctcagctg
    12601 aatgtgcttt gggcagaagc accaagcatt cttttgccag atacaacata ctacgaagaa
    12661 ggcaacgaaa aagctgagga attgcgtggt atttggcgtc agtcgcaaga aaagctttta
    12721 ccacaatttg gtttttcaac agaagaaatc aaggatcttt tggataaggt aattgaacta
    12781 gataagcaat tggccaagta tgtcttgtct cgtgaggaag gctcagaata tgccaaatta
    12841 taccatcctt atgtgtgggc tgattttaaa aaactagctc cagagcttcc tttggatagc
    12901 atttttgaaa agattttagg ccaagtacct gacaaggtta ttgttcctga ggaacgtttt
    12961 tggacagaat ttgcagccac ttattactct gaagccaatt gggatttact caaggctaat
    13021 ttgattgtgg acgcggctaa tgcttacaat gcttacttga cggatgatat tcgtgtggaa
    13081 tcaggcgctt attcgcgcgc tctttcagga acaccccaag ctatggacaa acaaaaagca
    13141 gccttttatt tggcgcaagg accgtttagc caagcgcttg gcttgtggta tactggtcaa
    13201 aaattctccc cagaagctaa ggctgatgtg gaaagcaagg tagcacgcat gattgaggtt
    13261 tataagtctc gtctagaaac ggctgattgg ttagcaccag ccacacgtga aaaagccatt
    13321 actaaattaa atgttatcac gccacatatt ggttacccag aaaaattacc agaaacctat
    13381 gctaaaaaag tgattgatga gagcttgtca ttggttgaaa atgcacagaa cttggctaaa
    13441 atcacgattg ctcacacttg gagtaaatgg aacaagccag ttgaccgtag tgagtggcat
    13501 atgccagccc acttagtcaa tgcttattat gatcctcagc aaaatcagat tgtctttcct
    13561 gcggcaatct tacaagagcc attttattct ttagatcaga gttcttcagc caattatgga
    13621 ggaattggtg cagtcattgc gcatgagatt tcacatgcct ttgacaccaa tggtgcttct
    13681 tttgatgaac atggtagcct aaatgattgg tggacacaag aagactatgc tgcctttaaa
    13741 gagcgtacag ataagattgt ggcgcagttt gacggcttag agtcacatgg tgctaaggtc
    13801 aatggtaaat tgacagtttc agaaaacgtc gctgatctag gtggggttgc ttgtgcttta
    13861 gaagcggcac aatcagaaga agacttctca gcccgtgact tctttattaa ctttgcgacg
    13921 atttggcgta tgaaggcccg tgaggagtac atgcaaatgc tagctagcat tgatgttcat
    13981 gccccgggtg aactgcgaac aaatgtcacc ttaaccaact ttgatgcttt ccatgagacc
    14041 tttgatatta aagaaggcga tgctatgtgg agagctccga aagaccgtgt gattatttgg
    14101 taattaggta gttgataaac cttcaaatgc ctgtgattat aaaaatgact gattctgtga
    14161 aacacaggat cagttttttt cttccttatt ggtgtccgtt ttgacacaac aaaaagacaa
    14221 ccctcaggaa agaaggttgc cttttttaga cttatcagaa ataagtgatt agttgttaag
    14281 ggcagcagcc atagtagctg caacttctga ttcaaagtcg ttagcttttt tctcgatacc
    14341 ttcaccaact tcaaaacgtg caaaagcaat cgctttagcg tttactgagt caaggtaggc
    14401 ttcaacagtt ttgctgtcgt ccatgatgta aacttgtgca agaagagtgt aagcttggtc
    14461 aactttagtg ttgtcaagca tgaagcggtc cattttacct gggatgattt tgtcccagat
    14521 cttttctggt ttgccttcag cagcaagttc agctttgatg tctgcttcag cagcagtaat
    14581 cacgtcgtct gataattgag cttttgaacc gtatttcaag aatggaagtg ctggtttgtc
    14641 aaccattgca cgcgattcgt tgtcaagttc gatagcgtgg ttcaattgag caagttcatc
    14701 tttgatgaat tgtgcatcaa gctcagtgta tgaaagaaca gttggtttca ttgcagcgat
    14761 atgcattgat acttgtttag caagagcatc gtcgccgcct tcgacaactg agataacccc
    14821 gatacggcca ccattatgtt ggtaagcacc gaagtgttgc tcatctgttt tttcaatcaa
    14881 agcaaaacga cggaatgaga ttttttctcc gatggtagca gttgcattaa cgtaagcttc
    14941 agcaagagtt tcacctgaag gcataacaag tgcaagtgct tcatcgttgt tagctggttt
    15001 gccttcagcg ataactttag cagttgcgtt taccaattca acgaattgag catttttagc
    15061 aacaaagtct gtttcagcgt taacttcaac aacagcagca acgttaccat gaacgtaaac
    15121 gcctgttaaa ccttcagcgg caacacggtc agctttttta gccgctttag ccattccttt
    15181 ttcacgaaga agttcaacgg ctttgtccat gtcaccatct gtttcaacaa gtgctttttt
    15241 agcgtccata acgccagcac cagatttttc acgtaattct tttacaagct tagctgtaat
    15301 ttctgccatg tgtagtatcc tccaaatgat atttgttttg gtttcaaaaa acgagacaga
    15361 gcggtttgct ttctgccccg tttggttttc gattgttaaa gacaaacgaa gtttgccata
    15421 agagttagga actctgtgct aattaagcgt tgtcgccttc gacaacttca acgatttctt
    15481 cgatcgaatc tgcttgagtg tcagcttcaa aagcaacgtc tgcatcttca ccttgacggc
    15541 cttcgataat agcgtcagct aatttagcag tgattaattt aacggcgcgg atagcgtcat
    15601 cgttagctgg aatgatgata tcgatatcat ctggatcagc gtttgtatca accatcgcta
    15661 cgactgggat accaagtttt ttagcttctt taacagcaat ttgttcttta tgtgggtcaa
    15721 caacatacat cacgtctggg atacgaggca tatcttcgat accgcccaag aatttttcaa
    15781 gacgagcgcg ttgtttgtta agaagtgcaa cttctttctt aggaagaacg tcaaaggttc
    15841 cttcttcttc catacgtttg atttctttca aacgagcgat acgtttttgg atagttcccc
    15901 agttggtaag cgttccaccc aaccaacggt ggttgatgaa gtattggcct gcacgcgttg
    15961 cttcgtcagc aactgcttca gcagcttgtt ttttagtacc aacaaacaag atgacagcat
    16021 cgtttgctgc agcatcacga acaaattcgt aagcttggtc agctaatttt acagtttgtt
    16081 gaagatcgat aacgtggata ccgttacgct ctgtgaagat gtatttagcc atcttagggt
    16141 tccagcgacg agtttggtga ccaaagtgaa caccagcctc aagaagttgt ttcattgaaa
    16201 ttactgccat gagtagtttc tcctttataa aatgtttttt cctcttccag acttcgactt
    16261 gcaggctaac ctagcggcaa caagcccaca attggtctag aatgagtatt tgccgtctac
    16321 acgaccctac tatattatca aaaaaagagg ttaaaagcaa ggagaaatgc tatggattcc
    16381 cttatttttg agatgactag cttctttgtt tattggtaag tgttaagaca agcttttgct
    16441 cattttgggt gacacttgcc aaatcgtttt atttaagata tagtgaattt gactaatttt
    16501 tggaggcgtt ttcatgacga agggtattcg atttcaattg cttggcagtc cccacatttt
    16561 tcttgataac aaagaacaat tttttgcctt tgccaaagca aatgctctcc tttattactt
    16621 agtggttaat ggatctgtta gccgcgaggt ggcggcgagt ctactttggg aaaataagaa
    16681 cacgcaaaca gcgaaaaaga atttacgaaa cgctatctac caggtcaata aagtcttgca
    16741 agctgatgtg attatttgtc ccaatcgcaa cctgctggtt ttgaataaaa cacttgatat
    16801 caaaacagat attaaccttt ttctggctga tccgctagct cacttagaac tctaccaagg
    16861 ggagttttta cagggctttt accttaaaag tggtgaggaa tttgatcttt gggtttcaaa
    16921 aatgcgtatg cagtatgaac aggtatacct aaaagcgtgt taccaaaaaa ttgaagaaaa
    16981 gctctcttta gatgccattg aagatgtcga ggaacattta aaacagctta ttgaacgtga
    17041 tgaatttgaa gagaaaaatt atcagctctt gatgaggctt tatcagcagg ggaattgtcc
    17101 tggtaaggtc atcgaaactt attatcagtt ggctaatgtg ttggataagg agctagggat
    17161 tcagccaagt ttgcaaagcc aacagattta tcaggaagtg gtcgctaaag atcgtaatga
    17221 acgcaaaatc aagcattttt tgcgcaacag taatcatttt ttggggcgga ttgatgagat
    17281 taagcagctg gaaaactatt ttgccaactg tttggcctgc caagaggtag gagctctgct
    17341 cttaattggt gatacaggga ttgggaaacg aaccctagcc agacaggtct tagccaatca
    17401 aacccaaacg tttcaaattg tcacagctaa atgttttcgt gaagaggcta tggattcctt
    17461 attgccttgg cgtaatatct tagatggcct gggagatttg gtgattcaaa accgcttatt
    17521 gaccaccaaa gcttggaagg ctgctcttaa acgctgtttt cctgtggcaa ccatttttca
    17581 agaagataac aaccaaccct ttatcaagga ccacaccagc ttgttggttt cctttattgt
    17641 tgatatttta caacatttgg cagaaatcaa ggcgctggta atccttattg aggattgtca
    17701 ttggatggat gaggatagtt tgaccttgtt gcaacgggtc atgaatcaat tggtccacta
    17761 tccgattgct tttgtcttga ccaagcatct aggaacgact cctgagctcg gtctttgttt
    17821 gaatgctttg atgagtcagg ggcgtttaga aagcatttgt ttggagcctt ttaatcggca
    17881 agaaagtttg gcttatatta acagtcaatt gggtagtcag ccagtgacgg aagaagaaat
    17941 ggagcacctc tatcaagcca gccaaggcaa ccctttcttt ttgtcagaat acactcatgc
    18001 cctactgcgt cacgaaaaat ttgtgccttt aacgcctgcc attaaggcta agttgggtct
    18061 taaactagct aatctaagta gtcgtgatga cgcattgtta aactatttgt cttgttgtcg
    18121 gaggcctatc cctctaaata ccctcgctca attgatgtta ctgcctttag aagaagtgat
    18181 cgagatggtg gataatctgg ggcactacta tattttggta gaagaaagcg taggagagga
    18241 ggtgttgatt tcatttcgtc agcgaattat tcaactctat agttatgacc gtttatcttt
    18301 gtcaaaaagg cgtttattgc acggacaaat tgccaaacgg ttagaagatt tactgcctat
    18361 tttgacacca agccctcact tattagatga cattgcttac cattatcagg aatcacggca
    18421 ggtgattaag gctttggaat acaaccttaa ctatctagat gctaccttgc catttcagca
    18481 tgagctgttt cccatttatt caaagagtat tggctccttg gaaaagtcag atcgtgacca
    18541 tcaacgctta atggaagagc agtttgataa gattcggcaa agcattgcgg atttggaact
    18601 gacctatgat aataaccgtg atttccagca gttgcttatt cgtttttctt accttgaagg
    18661 ccgttatgat attcgaacag ggaggtatca agaagggatt aaacatattc aaaaggtcat
    18721 cgctttggca accgagctaa aacagccctc cttcttgcta gaaggctatc gccagttaat
    18781 tcattactgt atccaagtgg aaaacaagcc agaaatgcgt tattacacta gtctttcatt
    18841 ggaggcagcg gttgctgcta atcattttga ggccattgcg attagtttgc ggttaaacgg
    18901 tctttatcat ttgattattg gggagttaaa tgaggcagag cgtctgcttc aacagtcgat
    18961 tgacttcttt aaggtgacgc caggcttgca agctaactat gcgattcaga ttgctgctgc
    19021 cttagattat ttgggggaga tcgcccagat tcgctatcag tttgaaaagg ccgttgctta
    19081 ccaaaaacaa gccattgcct tgaccgaaaa caagccagct gagttatcag tgagtatttt
    19141 ttatattgga ttagggattt cctactttta tttagctgat tttgaacaag ctgagcaaat
    19201 cttgagtttg gctaaggaag ctttggtcaa tcatagttat ccttggaaag aaacgcaact
    19261 tgaaatttac ctggccatga ttcaatggaa aaagggtaat tatcagccag ccttgactct
    19321 acttgattac agagaaacct tgatgtctag gtatcgcaat ccgcgagata agggcttggt
    19381 tttctatttg atggctgtgg tcaagtacca attgatacgt caaggagcta ccctaagtca
    19441 gcaggaaaag gaaatggcag accacctgtt gtcagaatcc tttgagtatt attatgagat
    19501 tgctagtact aacctcaacc cttaccgaga ttgtcatttg gtgagtgagt tgaacgattt
    19561 gcgtcaacaa ttatctgcta aaagctaagg aaaaccctct gattcacatc agagggtttt
    19621 agttatgttg tgccataatc tgtacgaggt aaaagataaa ggtggctgct aaattggcgg
    19681 tgtggttatc aatatcgtgt ggtggtgaaa cctcaaccac atcaaagcca actaattttc
    19741 cgctagctgc aatgtgttgc aaaactaaga cggcaagatt tgggtcaaca ccgagggact
    19801 ggatagcact aaccccaggt gcagcaccaa ctgagaaaca atccatgtcg atagtcaggt
    19861 agaccctttc ttgcccttct aagaaacgat caatggctcg gcagaccttt tgatggccca
    19921 tttggtagat gtcttgacct gttaaaaatt gaatgccctt ggattttgcc acaaagtcaa
    19981 ataggaaaag gttgttatta tgttcttgaa tgcctaaaac gaagtattta aagaggcgtt
    20041 tgtcagcaac cgcatcgtca aacatttgtc gaaagcctgt ccctgaatta gggcctgttt
    20101 ggtcgtaagg ccttaaatca aagtgggcgt ccatattgat gacagctagg tcatcacttg
    20161 aggataagct ttggcgtagg cctaagtagt ggccgtaggc ggtttcatgg ccacctccta
    20221 agacgatggg tttgagattg aggtcacaca ttcgtttgat ggctttgctt aaactgtttt
    20281 gcagttgttc caaagagcga ttggggccgt caatgttacc cacatcgtaa accataactt
    20341 ggtttcctaa atgccaaggg aatttggcta gctgggttcg tatggcagct ggactttcga
    20401 ccgctccgac acgaccatta ttgatataaa cgcccttatc acttttaaag ccaatcaagg
    20461 caaaatgtgt cccttcaaat ggggttagtg agctgtcgtt aaggtcaagg aaagtcatga
    20521 ccatgcccca tttggcagta tataagtcat cgtcgatccc actatgataa tagctagtgg
    20581 tggatgggta gtaatcttct agcatgcgcg tcatctcctt taggattatg atagcaaaat
    20641 aaaacttaca gtcaactctc tataggctgt catcactggt ttttaggaat agcagagcaa
    20701 taaaatcgtc tgcttttggt cccagttagt tagtctaaag aggccatgac ctctgccaca
    20761 gcccctctca gttaaagaag taccttattc actaaaattg gatactcaac tcaactgcct
    20821 gctcaaccgc ttcgaggaag cttgggtctt caatgactgt tgatgccttg tttagttcat
    20881 cgtagatttc gatgtgttta tcgtgttcga taaagttgac ttccttgcgg aagagatcgt
    20941 aggcaacctt agtcccttta cctagttcat gattttcaga tttgagatca agagcttggc
    21001 aggctgccat gatttcagta gccacgatgc ggcgagaatt tttaaggatt tcaaaggcct
    21061 tgcgagcagc ggtggtgccc atgctgacaa agtcttcttg gttctcacaa gatgggatag
    21121 aatccacact ggctggatgt gccaaaacct tgttttcaga agcaagagag gcacaggcgt
    21181 actgggtaat cataaagcct gaattgagac ctgggtattt gacaagaaag gatggcaatt
    21241 tgctgagctg gctattgacc aaacgttcca cgcggcgttc agaaacattt ccaatttcag
    21301 aaatggcgat gcctaagaag tcaaatggct gtgccattgg ttctccgtgg aagttacctc
    21361 ctgaaataac gtggccatct ttacagataa ttggattatc tgtgacagaa ttgatttcaa
    21421 tgtcaacttt ggatttgaca taggcgatac tgtctttgct agccccatga atttgaggca
    21481 tgcagcgcaa ggtgtaaggg tcttgcacac gagattgagt agctacggtt gtgttttggc
    21541 tgccttcaat gaggtttcgg atattgcggg ctgttgccaa ctggccgctt tgtgggcgaa
    21601 tggtgtgaag gttttcttca aatggactag taatcccgtt atgcacttca agggataggg
    21661 caccagctag gtctgacagt ttcaataatt gaatggcgtc ataggttgca agggcaccga
    21721 ttgcagtgag aacagttgtt ccgttgataa gggcgagtcc ttctttagcg gctaaagaaa
    21781 tcttgtcaat accagcttta tcaagagctt cttgaccaga aagaagctct cctttgtagt
    21841 aagctttccc tagaccaagc ataggaagca ccatgtgagc aagcggcgcc aaatctcctg
    21901 aagcccctag agaccctttt tcaggaatgt aaggatgaac ccctttattg agcagttcca
    21961 acagcttttc aatggtggat agacgaatac cagaataccc tttgacgaga gagttgatac
    22021 ggatcagcat gatagcgcgc acggcatctt ctggcaatgg gtcaccaaat ccactagcat
    22081 gggtacgaat caaattttct tggagttgaa ctgtatcttc tggtgagatg ctcacgttac
    22141 aaagggatcc aaaaccggtg gtcaccccgt aaaccacccg tttttcactg acaatgtcat
    22201 caacaatttt acgagaggca ttcacagctt caatagcact atcatcaatg cgacaggcta
    22261 tgccttggcg agcaatcgca atcacgtctt cgatagtaag gctttcgcca tctaaattaa
    22321 tcactcttgt catagttttt ctcctagatt tgttccttag ggggcatttg gtccatttgg
    22381 tggttacgtc cgtgcataag gtagtacaca ctacttgcaa tgatgacacc aactgcacca
    22441 taaacaaagt tcattgggtt gtcaccccaa atcataacta aactaacgat aactgcaaga
    22501 attgggataa taggaccaaa tggtactcgg aagatcacat tagcatcggg atcgtccttc
    22561 cgtaatttca taacggctag tgctgttgga atgtattgga agaagcggaa aataacactg
    22621 agttttgcta agttttcaaa tgagccagtg agtaggagta caatagcaat tgctcctgaa
    22681 accaagatag caacgagtgg tgcgccattt tgattttgct tggcaatagc agctggtaag
    22741 agcccttcat cagcaatggc agcaccgtaa cgtggcacca tgatggattc tcctatgtta
    22801 agacctgtaa tggaaattaa agcaccgatt gagaccatcc aagcgccagc agggcctatc
    22861 attttaacaa aggcatcttg aacaggtgca ttggtcatca tgatttgaga gccaagcatg
    22921 gcaatggttc caccgataat cagcatatat aagacagaga cgatactgat tgatcctaaa
    22981 agagcacgcg gtacattttt ttcagggtca cgcatttccc cagcgacaat agagagggtt
    23041 tcaaaaccga taaagccata gaagatataa acagcagtat tggagatagc ccctaagagg
    23101 ttagtccctg gttccaactg aacaaatggg gtaaagttag gaagcccgtt tttgatgaag
    23161 aaaagggtac aggcacaaaa ggcaacgatt ggaattaact tagcaatggt ggctgtgatg
    23221 gtgacaattt tagaggtttt caaaccagcg atattcatca aagatagtaa gatgattaac
    23281 ccaatgctaa gtggaatgtg ccaaccttca aaggcaggga aagtaatgat aaacattctg
    23341 gcaaacccag ctgccatggc tgcccaagcg aagatggtaa cggtccaacc aaggaagcca
    23401 acgttaaagc caataaaatc accaaaagct cgtttggaat attggaaggc cccgccgttt
    23461 ttcccaaaat aaccagagac ttctgcaaaa caaactgcca acatgatggt caaaatagct
    23521 gttccaaaca taacagcgat ggatgcaggg ccaaggccct tgtaaatggc cctaggtaag
    23581 agaaaaatac cagagccgat aacggcattg atcccgtaaa gagtggcacc gctcaagcta
    23641 aactttgcct gttctctttc ttgttcgttc atgtgatttg acgccataat aatgctctcc
    23701 tttttgtttg caaattgcgt tcaaatataa tggataaggt cgctaggaaa tgaggagata
    23761 gtcggtttag gagggtcctt cttgcaccta acgatagtga tgagctattg gttagcgatg
    23821 agaaataggt agccttttgt gatgatgtgt agtgatttca ttggagaaga ataggcatga
    23881 gtagtgtgat gcctatcttt atcccactaa gtcttatacc ataagcctgc ccaaacagct
    23941 actggagttt gggcggggct tgtttgattg aggcaaactt ttagatctga aaggctggcc
    24001 tcctgctcga ttaccaacaa gtgattggct tcaagctctt gattcgcctg attggtcaca
    24061 gaataagtca gtttgcttag ggcataaagc agttgacagt ccgctttagg tgcctcaaat
    24121 agtgtgtcag accagacggg taataattgc ccttggtatt ggtcatcata cattaaattc
    24181 atgtcttggc agattccacg actgacgatt ctggtatcgc cttcaaacgc ataaggttca
    24241 aaaggagtta gggaaatctc tttagcatga ctcaaatcac tcaatgtgat gggcttgtct
    24301 agggtcatta gaatcctgtg atagccatca agtaaggtaa aggttgtctg tcgtagggcc
    24361 acagttgact ttgagaggcg ataagagaat tctctctttt tgtaatctcc atcttcggga
    24421 taaaggaaca attggttggt ttcaccgcca gaccagtcag tttggaggta atcagagggc
    24481 gctttgatag ttacctttgt catttgttct ctccttgttt ccaattagaa tagtcctgtg
    24541 atgttgccct cctcgtcaat atcaatggtt tcgctggcag gtacttttgg aaggccaggc
    24601 atggtcatga tagcacccgt cagagcaacg ataaatcctg ctcctgcaga cactttgagg
    24661 ttgctaatag tcactgtaaa gtcagttggt gcgccaagtg ttttggcatc gtctgagaag
    24721 gaatattggg ttttggccat gcaaattggg tagttgccaa agcctaggcg ttctaagtca
    24781 gccagttcac gtttggctgc tgggctcaag gtgatgcctt taccaccgta aactttggta
    24841 acgattttag tcagtttggt ttcaatgcta tcgtcttcct cataaacaaa gcggaattga
    24901 ttgtcttgct cggctagtgt cacgactttt tcagccagtt cacggccacc agctccgcca
    24961 tttgcccaaa catcagaaat cacaacgtca acgccacgtt tgttgcaggc atcatagaca
    25021 gcttgtaatt cagcatcggt atcaagcggg aatttattga ttgcaacgac aactggaagg
    25081 ccatagacgt cttggatatt agccaaatgt ttgtcaaggt taggcaaacc atccacaacg
    25141 gcttgaacat tttcagtagc caagtcagtt ttttgaacgc caccgtgcat tttaagggca
    25201 cgaatagtgg ctactaggac aacggctgct ggacgaaggc ctgacatgcg gcatttgatg
    25261 tcaatgaatt tttcagctcc aaggtcagca ccaaatccag cttcggtaac ggcataatca
    25321 ccatatttca aggctagttt ggtggcgagg acactattac agccatgggc gatattagca
    25381 aatgggccac cgtgaatgag ggctggtgtg tgttccaggg tttgcacgag attaggatga
    25441 atcgcgtcct tgagcagagc ggctagggca ccaccagctt tcaagtcttt agctgttaca
    25501 ggttcgcctt gatagttgta accgatgatg attttttcaa ggcgggcttt gaggtcagag
    25561 atattttcgg ataggcacag gattgccatg atttcagagg cgacggtaat gtcgtaacca
    25621 tcctcacgag ggaccccgtt gaccttgcct tgcaagccgt caacaatatg acgaagctgg
    25681 cggtcattca tatccaccac acgtttccaa gtaatacgtc tggaatcaat gcctaggcta
    25741 ttgccatggt gaatgtggtt atcaatcaag gcagctaata agttgttggc gacaccgatg
    25801 gcatgaaagt cccctgtaaa gtgaaggttg atgtcttcca ttgggacaac ttgcgcgtgg
    25861 ccaccgccag cagctcctcc cttaacccca aaaacaggac caagagaagg ttcacgaagg
    25921 gcaataactg ctttttttcc aatggcagaa agagcatcta ccaatccaac ggaagtggtg
    25981 gttttgcctt caccagctgg tgttggtgag atagcagtga caagaatgag tttgccatca
    26041 ggtttgtctt ttaaggcgac cagttgacgg gcattaattt ttgccttgta cttaccatag
    26101 agacagagcg cttccttgtc gatccctaat tgatcggcaa ccttactgat aggttccata
    26161 gagacagagt tggctatttc aatatctgat aaaaccatag ttgctccttt acttgttaaa
    26221 caatatcgag aattttcgtg tagatgtcat ctgccaagtg acagcccttg tctaataagg
    26281 cttgtccttt ttggcgatag tcggtaacaa agtcttcatc tttgatgcca gacagattaa
    26341 tcaaaacatt caaccaagcg ccttgtaaac ctgcttttaa gtttaaagca gcaactccta
    26401 agtcgctagc agcatttgta ttagacttac cgacagctgt tgcagtgatc tcaagtgctt
    26461 cgaccatgag ggtcatcatc tcaaaaggtg attgtgcagc tgttttcaag gccttttgca
    26521 tggcagttcg tctagcagcc ttgtcttcgt cagtctcttt tggcatatca aaaacggcag
    26581 aaaccaggtt gaaggcttcg gtatctttgt caatggctgc aagcaagcta gcttgtagag
    26641 cggtgctttt agcatggacc tctgtaataa tatcttggta gtcagcgtat tttttcttac
    26701 cgagggtcaa ttcacagacc atcttagtca aggaaatgcc attagcgcca gagagagcag
    26761 cagcagaacc accacctgga tcaggggcat ctgagccaag gactttagcg aaatctgtta
    26821 agcttaaatc aactaaaccc atagagaacc tcctaaccta gcaaatggtt ttcaagaacc
    26881 tgtttatggt agtcaaagtc ctcaacttgt aagtagtatt cagccacatc gattaaggcc
    26941 ttggctggcg ctaagccgat gacttcagaa ccaataacat tcacaccgta gcgacgcgct
    27001 tcaaatttga tggtttcaaa agtacggtaa agagaacatt tttcaaagtt aaccatgttc
    27061 atggagactt gggcaatatg gcggtcttct aacatgacac cgatagcctt acaatatttg
    27121 tagccaccac ctgaaccgcg gataattttc gcaattttat gagcaatgtc gatattgtca
    27181 gtatccaaat taacattgaa ggcaaccaat ggcatgcgag caccaacggc agttacccca
    27241 gcagttgggt gaatcttacg atctccgtag tcaggtgccc aatcctcttc caacagtttt
    27301 tctggcatgc cttcgaattg tcctttacgg actttggcca ggttttgacg ttctgggcgt
    27361 gtggcagaat cttcataaag gaagattggg attccaagtt cacggttaat ccgttctgcg
    27421 acttgtttgg aaatctcaac acattcttgt gtagtgatgt ctttgatcgg aacgaatggg
    27481 cagacatcgg ttgctcccat acgagggtgt tcgccatgat gtttggtcat atcaatgttt
    27541 tcagaagcgt atttcaccag ttggaaagct gcttcttgaa tagactggtc atctccaacc
    27601 aaggtaaaca cgctccggtt gtggctcgca tcagaagagt agtcgagaag ggtcactcca
    27661 ggaatacttt tggccgtcgc taccaaacca tcgataacag cctgattttg gccttctgag
    27721 aagttaggaa tacattcaac aatttttgcc atgttaatct ccttttatgt cattgagtta
    27781 ctcattaagg gaataggtta cctactttag ataacgctta catttttagc tagcagttat
    27841 tagtgaaata attgatctac cgctgaaatc acaaggtcat cgtcagccaa atatgggata
    27901 gtgatatgat cagtacctgc atggagacgg ttgtattcaa tagcggtttc aatagcgtgc
    27961 tcattgcgag cccaattgcg acgagcaaca ccacccatgg tgtcccaagc aatggcagat
    28021 ttaataatct catcaatgcg ttcgctgcca tctaaaacaa gaccgaaacc accattgatg
    28081 gctttaccaa taccagttcc gccaccgtta tgaagagcca ctaaactcat accacgcgca
    28141 gcgttaccag cgtaacattg aaccgccata tcacaggtca cattggaacc gtctttaatg
    28201 tttgaggttt cacgaaatgg tgagtcggta ccagacacgt catggtggtc acgaccaatc
    28261 atgacaggac caatcttgcc tttgcggacc aattcattaa atttaagggc gatagtcaca
    28321 cgaccgatac agtcttggta aaggatccgg gcttgggtac caactacgag ttgatttttc
    28381 tcagcatcac gaatccagtt gtagttatca cggtcttgat aacggcggtc aggatcgata
    28441 gcttccatgg cagctttgtc agtggccacc aagtcttcgt gtttaccact caagcagacc
    28501 caacggaaag gtccatagcc atagtcaaaa agcataggtc ccatgatgtc ttcaacataa
    28561 gaaggccaga taaagccgtc tttgtcgtta cgaccattct tagaaatttc tgtaatacca
    28621 gagtcgtaaa cagacttcat aaaggcatta ccgtagtcaa agaaataggt gccattttca
    28681 gttaacgtct taatagcttc aaaatgccgt gccaaggtat catcaaccat ttggtggaag
    28741 gtatccttgt cttctgccaa gagccgggtt ctttcgtcaa agctaatgcc agctgggcag
    28801 tagccaccgt cataaatgtt gtgacaagag gtttggtcag acaaaagatc aacatgaatc
    28861 tgcttgtcat tgacgtactc taaaagatca acgatattac catggtaagc aatcgaagtg
    28921 gactccttag catctatggc tttttgggct aattgcagag cttcttcagg gctctcagca
    28981 atttggctaa cccaaccttg cgaatgacgg gtttcaatcc gagattggtc aacttcagca
    29041 ataatggcaa ctgctttagc aatttcagca gccttacctt gtgccccact catgcctcct
    29101 aaaccagatg agataaagag tttaccggtc aaatcaccat cgtcagccac tccaagtttg
    29161 agacgaccag catttaagag agtattaaat gttccatgaa cgattccttg tgggccaata
    29221 tacatccaac cacctgcggt catttgacca tagttggtga cacccatctc ttcagcgatt
    29281 tcccagtctt tcatgttgtc gtattcaccc accaaaaggc cattagtaat aatcacacga
    29341 ggcgcttcag gtttggattt gaaaagacca actggatgac cagactcaac caccaaggtt
    29401 tgttcatcag tcatgacttc taggtatttt ttaatcaaac aatattgcat ccagttggca
    29461 caaacagaac cagtttctcc atatgtgact agttcgtaag ggtacaaggc aatttcaaaa
    29521 ctcaagttat tgtcaatcat gacctgcatg gccttggcag ctgtacaatt tcccttgtac
    29581 tcgtcaatgg gtttgccgta aatgcggtct tttggtctaa agcggtagcc ataaatacgg
    29641 ccacgggttt tgagttcttc caaaaattct ggaatgactt cttcgtggaa cttcgtaggt
    29701 acatagcgta gggcattttt caaggcgatt tcggtctgag cctgggtcaa tcgaaaacct
    29761 ctgtctggtg ctcttcggat accttcttca aacacagtct tttccggtaa aacatcgtct
    29821 aacttaacag tcatagcggc agctatgtca gtttcactgt aaaatgacat agaaaactcc
    29881 tcctcaactc ctttttattg tcgagattag tctaacttag tctagtctat aaaaagtcaa
    29941 ccacgctttg aaatgcgaaa aaagtctaaa aaaaaatcaa aacctcattt tttgactaaa
    30001 atttgacgct taatcagtac acttgaggta tgacagataa agtcagtcag aggttaattg
    30061 ttgttaccaa agttgcaaag atcgcaacta ttgagtgggt gaggggggac tagtaatggc
    30121 tattaatcag ttgacaaacg atgttaaaaa aggaggtttt tatggttgct gatgtcttat
    30181 taacacattt taatcaacta ttttgtctaa atgatccagg tcatccttta actggtcaag
    30241 aaatgaaaaa agccactatc gttgaagatg gctatatagc catcaaagac agccttattg
    30301 tggctcttgg ttctggtgaa ccagatgctg agcttgtcgg tccacagact attatgcgtt
    30361 cttataaagg taaaattgca acgcctggta ttattgactg tcatacccat ttggtctatg
    30421 gtggcagtcg tgaacatgaa tttgccaaga aattagcagg ggtgtcttac ttggatattt
    30481 tagctcaagg tggtggtatt ttaagcacgg tgagggccac tcggtcagcc agctttgaca
    30541 acctttatca aaaatccaag agattgctag actacatgtt gcttcatgga gtgactactg
    30601 tcgaagcgaa aagtggctac ggccttgatt gggaaacaga aaaacgccaa ctggatgttg
    30661 ttgctgcttt agaaaaagat catcccattg atttggtgtc tacgtttatg gcagcccatg
    30721 cgattcctga agaatacaaa gggaatccta aggcttatct cgatgtgatt atcaaggata
    30781 tgcttcctgt tgttaaagag gaaaatctgg cagaattttg tgatattttc tgtgaaaaaa
    30841 atgtttttac agctgatgag tctcgctatc tgttaagcaa agccaaagaa atgggcttca
    30901 agcttcgtat tcacgcagat gaaattgcgt ctataggcgg agttgatgtc gcagcagagc
    30961 tcagcgcagt tagtgcagag catttgatga tgataacaga tgatggtatc gctaagttga
    31021 ttggtgctgg tgttattggt aatttgcttc cagccaccac ctttagttta atggaagaca
    31081 cttatgcccc cgctcgcaaa atgatcgatg ccggcatggc tatcactctc tcaacagata
    31141 gtaatccagg cagttgcccg actgctaaca tgcagtttgt gatgcaatta ggttgtttta
    31201 tgttacgttt aacaccgatt gaagtcttaa atgctgttac cattaacgcg gcctactctg
    31261 tcaatcgtca ggagagagtt ggtagtttga cagttggtaa agaagcagat attgccattt
    31321 ttgatgcccc aaatattgat tacccatttt atttctttgc caccaacttg attcaccaag
    31381 tctataaaaa aggacaactc acagttgacc gaggtcgtat tctttaaaaa atttaaaaaa
    31441 gaagctttga gcgttagctc aaaacttctt ttaaatatgc tgttttattg acgaatcaag
    31501 tagtcaaagg caccgatggc agcagtagca ccagacccca tggaaataat gatttgttta
    31561 taagctgaat cagtacagtc cccagcagca aagataccag gaatattggt tgacccatgt
    31621 ttatccacaa tgatttctcc gcggtcggtt aggttgacac cactatcttt gagccaagct
    31681 gtgtttggaa caagaccaat ttgaacaaag accccttcaa ggtcaaggtg tttgtcttca
    31741 ccgctatcac gctcagtgta gttaagacct gtaacatggt cctctccaac aatgtcctta
    31801 gtagaaacat ttttgatgat ggtcatattg ttagtcttag ctgcgcggtc ttgaagcact
    31861 ttgtcagctt taagttcagg caagaattct aaaacgtaaa cgtgtttagc aagaccagcc
    31921 aagtcaaggg ccgcttctaa tccagagttc ccaccaccga taacagcaac atctttgcct
    31981 tcaaagagag gaccgtcaca gtgagggcag taagtcaccc ctttattacg gaattcatct
    32041 tcaccaggaa cattaatgtt acgccatttg gccccaagag ctaagatagc agttttggct
    32101 tgtagaaccg caccattagc tagagtaacc tcaatgtttt cttttttctc aatagaagta
    32161 gctagttgtg ctttgataat atcaacatca taagacttag tatgggcctc cacttcggcc
    32221 attaattttg gtccttcagt gtaaagggta ccaatcatgt tttcgatgcc gaccgtttcc
    32281 atgacctgac caccaaaggt ttcagcaagt aaacctgttt ttagtccttt acgagctgca
    32341 tagatagcag cgctattgcc cgcagggcca ccaccaataa caaggacatc atagaggcct
    32401 ttatcagcaa aggcttcctc agaaagtggg ccagcgattt gttctaagag ttgctcaatg
    32461 gtagcgcgac cagaagtgaa ttcttccccg tctaaaaaga cagtagggac agacataatg
    32521 ccttttgctt tcacttcatc ttggaacatg ccgccttcta ccatagtgtg tgaaatcttg
    32581 tcgttcaaga cggacataat gtttaaagct tgaacaacat ctgggcagtt atggcaggtt
    32641 aagctgacat aagtttcaaa atgcaacgga cggtcaatgg ccttgatgcg atcaataaca
    32701 tcttgatcca cttttggagc acgtccagat acttgcaaga gagcaagaat aaaggacgtc
    32761 aattcgtggc ctaaaggaag accagcaaag acaaccccac taccgtgacc ttttttcgca
    32821 accttaaagc ttggttgtcg gtctaaagtg atgttttcaa tagaaatacg ctcagacata
    32881 gcagctattt cttccacaaa gtctttgact ttttgagact gctcattgtc accaagggaa
    32941 acttgcaaaa caagatcagc ttctaacagg gtgaggtatt gggcaagttg ttctttaata
    33001 tcaggactta atgccatagc tttcctccta aaatttatta aattttacca actaaatcaa
    33061 gacttggtgt caaagtttca gcgccttctt tccatttagc tggacaaact tcacctggat
    33121 gtttacggac gtattgggca gcgtgaattt tatcaatcaa ggtgctagcg tcacgtccaa
    33181 taccatcagc attaatttcc atcatttgga taataccatc tggatcaacg ataaatgttc
    33241 cacgttgagc aagtccgtct tcgccaagca cttcaaaggc ttgtgaaata aggtgtgaag
    33301 ggtcaccaat catagggtat gtgatagtgc caaccacatc tgaatcatca tgccaagctt
    33361 tatgaacaaa atgagtatca gtagagacag aataaacttc tacaccaaga gatttcagtg
    33421 tttcgtattg cttttgaagg tcaccgagtt cagttgggca aacaaatgaa aagtctgctg
    33481 ggtagaaaca aaaaactgcc cattttcctt taacgtcttc atttgtaaca gtgatgaatt
    33541 ttccatcgtg ataagcttga gctgaaaatt cagcaatttc ttttccaatt agagacatat
    33601 agttgtcctc cttttttata gttttatact tgtattataa aagaacaaca agattatgtc
    33661 tactcagaaa cccttgattt tactgggaaa tcagcgattg ttttctgaca attcagttgt
    33721 gaaacaaatc acattaatta aaatgattct aaataagctg aagatgctgt taaatcaaa
//
LOCUS       DAUDWO010000022        32758 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.022, whole genome shotgun sequence.
ACCESSION   DAUDWO010000022 DAUDWO010000000
VERSION     DAUDWO010000022.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 32758)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32758)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32758
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.022"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(143..2308)
                     /locus_tag="VHC05_001003"
     CDS             complement(143..2308)
                     /locus_tag="VHC05_001003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994220.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEQ5402322.1"
                     /translation="MITIKNPKILKWLKYVLSAILSLIILVIIIGGLLFTFYISSAPK
                     LSEAQLKSTNSSLVYDGNNNLIADLGSEKRENVTADSIPINLVNAITSIEDKRFFNHR
                     GVDLYRIFGAAFHNLTSQTTQGGSTLDQQLIKLAYFSTNESDQTLKRKAQEVWLALQM
                     ERKYTKQEILTFYINKVYMGNGNYGMLTAAKSYYGKDLKDLSYAQLALLAGIPQAPSQ
                     YDPYLHPEAAQNRRNVVLQQMYMEKHLTKAEYETAIATPVAEGLQSLQQRSTYPKYMD
                     NYLKQVIEEVKKETNKDIFTAGLKVYTNIIPDAQQTLYNIYHSGDYVYYPDQDFQVAS
                     TIVDVTNGHVIAQLGGRNQDENVSFGTNQAVLTDRDWGSTMKPITAYAPAIESGVYTS
                     TAQSTNDSVYYWPGTTTQLFNWDLRYNGWMTIQAAIMLSRNVPAVRALEAAGLDYARS
                     FLSSLGINYPEMHYSNAISSNNSSSDKKYGASSEKMAAAYAAFANGGIYHKPRYVNKV
                     EFSDGTSKTFDEKGKRAMKETTAYMMTDMLKTVLTYGTGTAAAIPGVAQAGKTGTSNY
                     TDEELAKIGEKYGLYPDYVGTLAPDENFVGFTKRYAMAVWTGYKNRLTPVYGSSLEIA
                     SDVYRSMMTYLTNGYSEDWTMPNGLYRSGGFLYLSGTYASNTDYTNSVYNNLYSNNTT
                     TASSQTTSDDTSSSNDTSNSTNTDNNGSHPSTDDKKTTH"
     gene            complement(2295..2903)
                     /gene="recU"
                     /locus_tag="VHC05_001004"
     CDS             complement(2295..2903)
                     /gene="recU"
                     /locus_tag="VHC05_001004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RecU"
                     /protein_id="HEQ5402323.1"
                     /translation="MVNYPHNLIRQKVSSVQKQTKQNKVDFANRGMSFEAAINATNDY
                     YLSRQIAVIHKKPTPVQIVKVDYPKRSRAKIVEAYFRQASTTDYCGVYKGHYVDFEAK
                     ETRQKTAMPMKNFHLHQIEHMACVLHQKGICFVLLHFSTLKETYYLPAQALISFYQID
                     NGSKSMPIDYIRKNGFKVAFGAFPQVPYLNIIEQNFLGGDYN"
     gene            2984..3499
                     /locus_tag="VHC05_001005"
     CDS             2984..3499
                     /locus_tag="VHC05_001005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1273 domain-containing protein"
                     /protein_id="HEQ5402324.1"
                     /translation="MTAILITGYRSFEIGIFDHKDPRVSIIKQAIRKDLIGYLENGVD
                     WFIFTGNLGFEQWALEVANELKEEYPLQIATIFLFETHGDRWNEKNQEVLSQFRAVDF
                     VKYYFPNYEQPTQFSQYYQFLLEKTEGAYVFYDTENETNLKYFLKKAKDMPHYQLLLL
                     TFDRLNDMSQS"
     gene            3621..3947
                     /gene="gpsB"
                     /locus_tag="VHC05_001006"
     CDS             3621..3947
                     /gene="gpsB"
                     /locus_tag="VHC05_001006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008089675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division regulator GpsB"
                     /protein_id="HEQ5402325.1"
                     /translation="MTSIIYSPKDIFEQEFKTSMRGFDKKEVDEFLDNVIKDYENFNA
                     QIEALKAENEALKKAKFQARNTVSATVQQPVPQPTRVAQSATNFDILKRISKLEKEVF
                     GKQIIE"
     gene            3961..4329
                     /gene="rnpB"
                     /locus_tag="VHC05_001007"
     ncRNA           3961..4329
                     /ncRNA_class="RNase_P_RNA"
                     /gene="rnpB"
                     /locus_tag="VHC05_001007"
                     /product="RNase P RNA component class B"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00011"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00011"
     gene            4392..5546
                     /locus_tag="VHC05_001008"
     CDS             4392..5546
                     /locus_tag="VHC05_001008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="HEQ5402326.1"
                     /translation="MKETFRLVATAAAGLEAVVGKEVRALGFDCQVENGKVYFEGDVE
                     AIVKTNLWLRAADRIKIIVGQFPARTFEELFQGVFALDWENYLPLGAKFPISKAKCVK
                     SKLHNEPSVQAITKKAVVKKLQKHFHRPEGVPLQEVGSTFNIEVSILKDQATIMIDTT
                     GSSLFKRGYRVQKGGAPIKENMAAAILALSNWFPDKPLVDPTCGSGTFCIEAALIGMN
                     IAPGFNRSFAFEEWSWVDKDMVQQVRDDAEQEANYEIELDISGFDIDGRMIEIAKSNA
                     EEAGLSDVITFKQMRLQDFRTDKVNGVVISNPPYGERLLDDKAVDILYNEMGQTFAPL
                     KTWSKFILTSDELFELKYGQKADKKRKLYNGTLKVDLYQFYGERVKRHLI"
     gene            5560..7029
                     /locus_tag="VHC05_001009"
     CDS             5560..7029
                     /locus_tag="VHC05_001009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402327.1"
                     /translation="MSEESKEVEVTKESQTLGLNEAKSMTIGEAVRKQSEIKAGVTKD
                     DSILDKYIKQHRDEVSSQKFDAKYTELDTASLDNFIKKQREALSKAGLVDDEPVSAES
                     AEQDSTLVEEVAEDLAPMETTAVVTGIPVEATVPVLDLDPSERVIPEPQITKEEPKRD
                     QFLSEDSHHPAKQNTKKGWLIALFLLLLAILAVVFGWNHFLRQDSGKTTQTASKQTKT
                     SLQTDSAKKATRLKAAAKAFEKQYGTFYTDATKSKLKNSAFATLPDLEAALKALEGSA
                     YYDKAKAKVDSLKKAIAAITAVNGKFVSDVVVDGEKVSAEVKADANFDDLSSATLTTG
                     NANLDAVLQASITEGRQQLASKAEAAKAANEQEAQDQAAQGQSTSVAPSGYGLTSYDP
                     ASLQRHLSRVPYNQDVIADRANPSWAFNPGVLEKIVATSQARGYISGNQYILEPVNII
                     NGNGYYNMFKPDGTYLFSINCKTGYFVGNGKGYADALDY"
     gene            complement(7174..7656)
                     /locus_tag="VHC05_001010"
     CDS             complement(7174..7656)
                     /locus_tag="VHC05_001010"
                     /EC_number="4.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteine lyase"
                     /protein_id="HEQ5402328.1"
                     /translation="MTKEVIVESFELDHTIVKAPYVRLISEEFGPKGDRITNFDVRLV
                     QPNQNSIETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIMWGKHSSTDIAKV
                     IKSSLEEIATGITWEDVPGTTLESCGNYKDHNLFAAKEWAQLIIDQGISDDPFSRHVI
                     "
     gene            complement(7730..9061)
                     /locus_tag="VHC05_001011"
     CDS             complement(7730..9061)
                     /locus_tag="VHC05_001011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HEQ5402329.1"
                     /translation="MEIIGSLGVLVGVIVIIYLSVKEVNIIIAAPLATSLVILFNQMD
                     PTTTLLGKEPNQFMGALSTYILNYFAIFLLGSILAKLMETSGATTSIADYILKKVGHD
                     SPYKVLVAIFLISAILTYGGISLFVVMFAVLPLARSLFKKMDLAWNLIQVPLWLGIAT
                     FTMTILPGTPAIQNVIPIQYLDTSLTAAAIPSIVGSIGCVTFGLFYMKYCLAKSMARG
                     ETYATYAFDNEIQVKTKNLPHFLASILPLLLLIIIALTGSLFGNDFFKKNIIFIALLA
                     AILTASWLFRQFIPNKIAVFNLGASSSIAPIFATASAVAFGAVVMIAPGFTFFSDLIL
                     NIPGNPLISLAVLTSSMSAITGSSSGALGIVMPNFAQYYLDQGLNPEMIHRVATIASN
                     IFTIVPQSGVFLTFLALTGLNHKNAFKETFITVSVSTFIAQVIVIAFDLFS"
     gene            complement(9132..9911)
                     /locus_tag="VHC05_001012"
     CDS             complement(9132..9911)
                     /locus_tag="VHC05_001012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxybutyrate dehydrogenase"
                     /protein_id="HEQ5402330.1"
                     /translation="MTHTKEVAFITGAASGIGKQIGETLLKEGKTVVFSDINQEKLDQ
                     VVADYTKEGYDAFSVVCDVTKEEAINAAIDTVVEKYGRIDILVNNAGLQHVAMIEDFP
                     TEKFEFMIKIMLTAPFIAIKRAFPTMKAQKHGRIINMASINGVIGFAGKSAYNSAKHG
                     LIGLTKVTALEAADSGITVNAICPGYVDTPLVRGQFEDLSKTRGIPLENVLEEVLYPL
                     VPQKRLIDVQEIADYVSFLASDKAKGVTGQACILDGGYTAQ"
     gene            complement(9944..10603)
                     /locus_tag="VHC05_001013"
     CDS             complement(9944..10603)
                     /locus_tag="VHC05_001013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacid CoA-transferase subunit B"
                     /protein_id="HEQ5402331.1"
                     /translation="MGTSATVLSKEEIQTRIAKRVAQELEHNTLVNLGIGLPTKVANY
                     IPKGVTITLQSENGFVGLTGLTDDHYDPTIVNAGGQPVSIAPGGAFFDSSTSFGIIRG
                     GHVAATVLGALQVDKEASIANYLIPGKMVPGMGGAMDLLVGAKKVIVAMEHTNKGKAK
                     ILDKCTLPLTAQNVVNLIITEMGVFEYQDEGLCALEINPDYTFEDVQNVTEVTLIDKT
                     N"
     gene            complement(10605..11255)
                     /locus_tag="VHC05_001014"
     CDS             complement(10605..11255)
                     /locus_tag="VHC05_001014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase subunit A"
                     /protein_id="HEQ5402332.1"
                     /translation="MCKEITIKEAVAHVKDGDTIMVGGFMTNGTPEKLIDALVEKGVK
                     DLTLICNDAGFPDKGVGKMVANKQFSTIIASHIGLNREAGRQMTEGETVIDLVPQGTL
                     AERIRSGGFGLGGFLTPTGIGTEVAKGKEVITIDGKDYLLETPLKADVALIFANKADK
                     NGNLQYAGSENNFNHVMAANAKTTIVEAREIVDVGQMDPNFVHTPGIFVNYLVKGA"
     gene            complement(11279..12466)
                     /locus_tag="VHC05_001015"
     CDS             complement(11279..12466)
                     /locus_tag="VHC05_001015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="HEQ5402333.1"
                     /translation="MKNIVIVEALRTPIGAFGGSFKSVSAVELGTTVLKKILDKTQVK
                     PEMVDEVILGNVLHAGLGQNVARQIAIHSGIPSDKTAFTLDMVCGSGLKAIQLATQSI
                     MLGDADIVIAGGVENMSQAAYVSTQHRFGQRLGNSQLIDTLVHDGLTDAFNNYHMGIT
                     AENVAQKYGISREEQDQFALESQEKAAKALENHRFADEIVPVSVPQRRKDPLIVTTDE
                     YPKVDTSLEKLQQLRPAFLPKEGTVTAGNASGINDGAALLMLMTEEKALELGLTPLVT
                     IESYASAGVAPELMGAGPIPATQKVLKKAGLTISDLDLVESNEAFAAQSLAVLKDLKL
                     NPEIVNVNGGAIALGHPIGASGARILVTLIHEMKKRQVTRGLATLCIGGGQGTAVIVK
                     NNT"
     gene            12665..13561
                     /locus_tag="VHC05_001016"
     CDS             12665..13561
                     /locus_tag="VHC05_001016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEQ5402334.1"
                     /translation="MDIKQIRYFIAIVENHFNLSQAAELLYVSQPTLSMMINDFEKRE
                     NVKLFKRKRGRIIGLTYLGDNYYKDAQKVLSLYDDMFLKLHDHSKGLKGSINIGIPPL
                     ILSVVFSEVMPKLILENPGIQFNVKEIGAYQLKNELLVGNVDVAVLLSPTGIADNLVE
                     TYETQRSELSVCLSPRHRLASKKVIQWEDLTDEQLALFDPSFMVHHLVLEACERHQVR
                     PNIILTSSSWDFMLNSTKINHNVLTICPKPITELYQLKDIKCIPMERPISWRVVLTRL
                     RKKSNSEIEAYIMDDLLQSFFK"
     gene            13691..15298
                     /locus_tag="VHC05_001017"
     CDS             13691..15298
                     /locus_tag="VHC05_001017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Y"
                     /protein_id="HEQ5402335.1"
                     /translation="MVNIILLIVSALIGLILGYALISIRLKSAKEAAELTLLNAEQEA
                     VDIRGKAEVDAEHIKKTAKRESKANRKELLLEAKEEARKYREEIEQEFKSERQELKQL
                     ETRLAERSLTLDRKDENLSSKEKVLDSKEQSLTDKSKHIDERQLQVEKLEEEKKAELE
                     KVAAMTIAEAREVILMETENKLTHEIATRIRDAERDIKDRTVKTAKDLLAQAMQRLAG
                     EYVTEQTITSVHLPDDNMKGRIIGREGRNIRTLESLTGIDVIIDDTPEVVILSGFDPI
                     RREIARMTLESLIADGRIHPARIEELVEKNRLEMDNRIREYGEAAAYEIGAPNLHPDL
                     IKIMGRLQFRTSFGQNVLRHSVEVGKLAGILAGELGENVALARRAGFLHDMGKAIDRE
                     VEGSHVEIGMEFARKYKEHPVVVNTIASHHGDVEPDSVIAVLVAAADALSSARPGARN
                     ESMENYIKRLRDLEEIATSFDGVQNSFALQAGREIRIMVQPEKISDDQVVILSHKVRE
                     KIENNLDYPGNIKVTVIREMRAVDYAK"
     gene            15408..16043
                     /gene="gmk"
                     /locus_tag="VHC05_001018"
     CDS             15408..16043
                     /gene="gmk"
                     /locus_tag="VHC05_001018"
                     /EC_number="2.7.4.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HEQ5402336.1"
                     /translation="MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQ
                     RPGEVDGVDYFFRTREEFEELIKTGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLE
                     IEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALM
                     REYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKMIKITKNPFKAK"
     gene            16059..16376
                     /locus_tag="VHC05_001019"
     CDS             16059..16376
                     /locus_tag="VHC05_001019"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000979238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="HEQ5402337.1"
                     /translation="MMLKPSIDTLLDKVPSKYSLVILQAKRAHELEAGATPTQEFKSV
                     KSTLQALEEIESGNVVIHPDPSAKREAVRAKIEAERLAKEEEERKIKEQIAKEKEEEG
                     EKI"
     gene            16441..18825
                     /locus_tag="VHC05_001020"
     CDS             16441..18825
                     /locus_tag="VHC05_001020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein N'"
                     /protein_id="HEQ5402338.1"
                     /translation="MEKVAHVIVDIPLMQTDKPFSYGIPKELVSLVQLGSRVHVPFGK
                     GNRLLQGFIIGFGQEDSSSLKLIQTVLDPEPVLNQEQLTLADQLRKTVFSYKITLLKA
                     MIPNLLNSNYDKVLRPESGLKKSDRDFLFEGKPSVLYSTLDREKGKIALKGIQAGHIT
                     VSYLAKDKKNLKTEKYYHVDLDALAVHPISSRAKKRQLLKDYLLTHTKEAKLATLYQA
                     FSRDVVTYFVTNHLIRIDERPIDRSESYFDQIKPSSFLTLNEQQASAVTEIVEQIGKP
                     SKPFLIEGITGSGKTEVYLHIIEAVLKQDKTAIVLVPEISLTPQMTSRFISRFGKQVA
                     IMHSGLSDGEKFDEWRKIKTGQAKVVVGARSAIFSPLERIGAIIIDEEHESTYKQESN
                     PRYHAREVALLRAKHHQAVVVMGSATPSIESRARASKGVYHFIQLTQRANPLAKIPEV
                     TIVDFRDYIGQQAVSNFTPYLIDKVKERLVKKEQVVLMLNRRGYSSFVMCRDCGYVDK
                     CPNCDISLTLHMDTKTMNCHYCGFQKPIPITCPECHSNSIRYYGTGTQKAFDELQGVI
                     PEAKILRMDVDTTRKKRSHKTILDSFGRQEADILLGTQMIAKGLDFPNVTLVGVLNAD
                     TSLNLPDFRASEKTFQLLTQVAGRAGRAHKPGEVLIQTYNPDHYAIQLAKQQDFEAFY
                     RYEMAIRRQMAYPPYYFTVGITLSHRLEASVVKKAYQVTELLKSHLSNNIKILGPTPK
                     PIARTHNLYHYQILLKYRFEDNLEETLNRILDWSQEADNRHLKLIIDCEPQQFL"
     gene            18887..19822
                     /locus_tag="VHC05_001021"
     CDS             18887..19822
                     /locus_tag="VHC05_001021"
                     /EC_number="2.1.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="HEQ5402339.1"
                     /translation="MIKLLFMGTPQFSATVLKGLLDNPAYEILGVVTQPDRAVGRKKD
                     IKVTPVKQLALEHGISIYQPEKLSGSQELIEIMGLGADGIITAAFGQFLPTLLLDSVS
                     FAINVHASLLPKYRGGAPIHYAIMNGDKEAGVTIMEMIKEMDAGDMVAKASTPILETD
                     NVGTLFEKLAIIGRDLLLDSLPAYLSGELKPIPQDHSQATFSPNISPEQEKLDWTMSN
                     QEVFSHIRGMNPWPVAHTFLEGQRLKIYEAQLAEGEGLPGQVIVKTKKSLVIATGQGA
                     LSLIVVQPAGKPKMSIIDFLNGIGRKLEVGDIIGR"
     gene            19812..21134
                     /gene="rsmB"
                     /locus_tag="VHC05_001022"
     CDS             19812..21134
                     /gene="rsmB"
                     /locus_tag="VHC05_001022"
                     /EC_number="2.1.1.176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003060995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="HEQ5402340.1"
                     /translation="MADNWKKSTRGKALLVIEAIFDQGAYTNIALNQQLSSKALSAKD
                     RALLTEIVYGTVSRKISLEWYLAHYVKDRDKLDKWVYYLLMLSLYQLIYLDKLPAHAI
                     VNDAVGIAKNRGNKKGAEKFVNAILRQFTSHPLPDMETIKRRNKYYSVKYSLPVWLVK
                     KLEDQFGSDRAVAIMESLFMRSKASTRVTDPLKLEEVAEALDAERSLLSATGLTKASG
                     HFAASDYFTNGDITIQDESSQLVAPTLNIDGDDIILDACSAPGGKTSHIASYLKTGKV
                     IALDLYDHKLELVKENANRLGVADNIETRKLDAREVHRHFEKDSFDKILVDAPCSGIG
                     LIRRKPDIKYNKESQDFNALQAIQLEILSSVCQTLRKGGIITYSTCTIFDEENRQVIE
                     AFLQSHPNFEQVKLNHTQADIVKDGYLIITPEQYQTDGFFIGQVRRVL"
     gene            21172..21912
                     /locus_tag="VHC05_001023"
     CDS             21172..21912
                     /locus_tag="VHC05_001023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="HEQ5402341.1"
                     /translation="MKISLKTDIGQKRSNNQDFINKFDNKKGITLVILADGMGGHRAG
                     NIASEMTVTDLGREWVKTDFTELSQIRDWLFETIQSENQRIYDLGQSEDFKGMGTTVE
                     AVALVESSAIYAHIGDSRIGLVHDGHYTLLTSDHSLVNELVKAGQITEEEAASHPQRN
                     IITQSIGQASPVEPDLGVRVLEPGDYLVINSDGLTNMISNDEIVTILGSKVSLDEKNQ
                     EMIDLANLRGGLDNITIALVHNESEDVE"
     gene            21909..23807
                     /gene="pknB"
                     /locus_tag="VHC05_001024"
     CDS             21909..23807
                     /gene="pknB"
                     /locus_tag="VHC05_001024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="HEQ5402342.1"
                     /translation="MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVL
                     RTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIGEEDGQQFLVMEYVDGADLKRYI
                     QNHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKEGVVKVTDFGIAVA
                     FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAV
                     TIALQHFQKPLPSIIEENHNVPQALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYN
                     RSRERKIIFEDVESTKPLPKVASGPTASVKLSPPTPTVLTQESRLDQTNQTDALQPPT
                     KKKKSGRFLGTLFKILFSFFIVGVALFTYLILTKPTSVKVPNVAGTSLKVAKQELYDV
                     GLKVGKIRQIESDTVAEGNVVRTDPKAGTAKRQGSSITLYVSIGNKGFDMENYKGLDY
                     QEAMNSLIETYGVPKSKIKIERIVTNEYPENTVISQSPSAGDKFNPNGKSKITLSVAV
                     SDTITMPMVTEYSYADAVNTLTALGIDASRIKAYVPSSSSATGFVPIHSPSSKAIVSG
                     QSPYYGTSLSLSDKGEISLYLYPEETHSSSSSSSSTSSSNSSSTNDSTAPGSNTELSP
                     SETTSQTP"
     gene            23930..24622
                     /locus_tag="VHC05_001025"
     CDS             23930..24622
                     /locus_tag="VHC05_001025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-active antibiotics response protein"
                     /protein_id="HEQ5402343.1"
                     /translation="MKKFQFFLLIECILLAMGIMTILDNDLSSFILILVLILLALRFY
                     NQDSRNNFLLTVSLLFLFLIFMLNPYIIMAVLLGIVYIFINHFSQVKKKNRFALIRFK
                     EEKIEVNNTKHQWIGTANYESDYYCFDDINIIRISGNDTVDLTNVIVTGMDNIIVIRK
                     IFGNTTILVPIDVTVTLDVSSIYGSVDFFRCQQYDLRNESIKLKETDNQSLKKVKIIV
                     TTIAGNVEVDRR"
     gene            24619..25623
                     /locus_tag="VHC05_001026"
     CDS             24619..25623
                     /locus_tag="VHC05_001026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEQ5402344.1"
                     /translation="MKKRYYALVWLYSTITILSIVFVVMDNLGITINYLRNHLWQVER
                     LGFSILLLIVSVTLLLLLLWIIMDDNSKRNINQNLKYILNNRRLYLDETSEINTNLSR
                     LSKKMSHLTANMQKKESAYILDSQEVVKQERKRIARDLHDTVSQELFASSLILSGISM
                     SLEQLDKTQLQTQLTTVEAMLQNAQNDLRILLLHLRPTELANRTLSEGLHMILKELTD
                     KSDIEVIYKETIAQLPKTMEDNLFRIAQEFISNTLKHAKASRIEVYLNQTSTELQLKM
                     IDDGVGFDMDQVRDLSYGLKNIEDRVNDLAGNLHLISQKGKGVSMDIRLPIVKGNDDE
                     "
     gene            25616..26257
                     /locus_tag="VHC05_001027"
     CDS             25616..26257
                     /locus_tag="VHC05_001027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5402345.1"
                     /translation="MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDL
                     ALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKVLVLTSYLDNEKIYPVIDAGAKG
                     YMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
                     KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN"
     gene            26294..27694
                     /locus_tag="VHC05_001028"
     CDS             26294..27694
                     /locus_tag="VHC05_001028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEQ5402346.1"
                     /translation="MDAKLKYKAKKIKMVFFDIDDTLRVKDTGYMPESIQRVFKALKA
                     KGILVGIASGRARYGVPQEVQDLHADYCVKLNGAYVKDDAKTIIFQAPIPADVVVAYK
                     KWADDMGIFYGMAGRHEAVLSARNDMISNAIDNVYAQLEVCPDYNEYHDVYQMWTFED
                     KGDGLQLPAELAEHLRLVRWHDNSSDVVLKGTSKALGVSKVVDHLGLKPENILVFGDE
                     LNDLELFDYAGISIAMGVSHPRLQEKADVITKKVEEDGILYALEELGLIDKELQFPQL
                     DLENHTGPKVTIKTNHGDMTLVLFPEHSPKTVANFLGLAKEGYYDGIIFHRVIPEFMI
                     QGGDPTGTGMGGQSIYGESFEDEFSDELYNLRGALSMANAGPNTNGSQFFIVQNSKIP
                     YAKKELERGGWPTPIAAAYAENGGTPHLDRRHTVFGQLADDASFKVLDLIASVETGAQ
                     DKPKEDVIIKTIEVFD"
     gene            27694..28071
                     /locus_tag="VHC05_001029"
     CDS             27694..28071
                     /locus_tag="VHC05_001029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HEQ5402347.1"
                     /translation="MKIGDKLHGTITGIKPYGAFVALDNGTTGLIHISEIKTGFIDDI
                     DQLLAIGNQVLVQVIDIDEYSKKASLSMRTLAEEKQHFFHRHRYSNSRHKIGFRPLEE
                     QLPQWIEESLQFLKKNTKKSLEP"
     gene            complement(28089..29030)
                     /gene="cysK"
                     /locus_tag="VHC05_001030"
     CDS             complement(28089..29030)
                     /gene="cysK"
                     /locus_tag="VHC05_001030"
                     /EC_number="2.5.1.47"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase A"
                     /protein_id="HEQ5402348.1"
                     /translation="MTKIYKTITELVGQTPIIKLNRLIPNEAADVYVKLEAFNPGSSV
                     KDRIALSMIEAAEAEGLISPGDVIIEPTSGNTGIGLAWVGAAKGYRVIIVMPETMSLE
                     RRQIIQAYGAELVLTPGAEGMKGAIAKAETLAIELGAWMPMQFNNPANPSIHEKTTAQ
                     EILEAFKEISLDAFVSGVGTGGTLSGVSHVLKKASPETAIYAVEAEESAVLSGQEPGP
                     HKIQGISAGFIPNTLDTKAYDQIIRVKSKDALETARLTGAKEGFLVGISSGAALYAAI
                     EVAKQLGKGKHVLTILPDNGERYLSTELYDVPVIKTK"
     gene            complement(29158..29790)
                     /locus_tag="VHC05_001031"
     CDS             complement(29158..29790)
                     /locus_tag="VHC05_001031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YigZ family protein"
                     /protein_id="HEQ5402349.1"
                     /translation="MEHFKTIKSSGFFEESIKKSRFICHIKRVSTEEDGKNFVNAIKK
                     EHYKANHSCFAMIIGNNSQIKRSSDDGEPSGTAGIPILSVLEKQCLTNVVVVVTRYFG
                     GIKLGTGGLIRAYSNMTATAIKRFGIIEVKQQIGLEITLSYPQYQLYSNLLDQLALTE
                     TETKFSDTIKTTLYCDTERVENLIDTLTNYYHGQISCEKIGSKVIEFPCD"
     gene            29846..31171
                     /locus_tag="VHC05_001032"
     CDS             29846..31171
                     /locus_tag="VHC05_001032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEQ5402350.1"
                     /translation="MESIENSYGRLLLESQLPDSARQLAQPLKSVVISRGKMICQRCH
                     YQLDEEARLPSGAYYCRFCLVFGRNQSDKLLYAIPPMHFPKGNYLVWSGQLTAYQEMI
                     SQQLLINMQNQKTTLVHAVTGAGKTEMIYAAIEAVINTGGWVCIASPRVDVCVEVATR
                     LSQAFSCSICLMHAESFPYQRAPIIVATTHQLLKFHKAFDLLIIDEVDAFPFVNNIQL
                     HYAASQALKEGGAKILLTATSTRTLERKVNKGEVVKLTLARRFHNRPLVIPKFIRSFN
                     LFKMIHRQKLPPKILKYLKKQRKTGYPLLIFLPTILMAESVTAILKELLPAEQIACVS
                     SQSQNRKEDITAFRQGKKTILITTTILERGVTFPQIDVFVLGSHHRVYSSQSLVQIAG
                     RVGRSIDRPDGTLYFFHEGISKAMLLARKEIKEMNYKGYSHDLSTMSTN"
     gene            31143..31808
                     /locus_tag="VHC05_001033"
     CDS             31143..31808
                     /locus_tag="VHC05_001033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComF family protein"
                     /protein_id="HEQ5402351.1"
                     /translation="MICLLCQQISQTPISITEIIFLRRISSPICQQCQKSFQKIGKSV
                     CATCCANSDIIACRDCLKWENKGYNVNHRSLYCYNAAMKAYFSQYKFQGDYLLRKVFA
                     VELADVITKYYKGYIPVPVPVNPGCFRERQFNQVSAILEAANVSYLSLFEKLDNTHQS
                     SRTKKERLLVEKSYRLLKVSNIPDKILIVDDIYTTGSTIIALRKQLAKVANSDIKSLS
                     IAR"
     gene            31888..32436
                     /gene="raiA"
                     /locus_tag="VHC05_001034"
     CDS             31888..32436
                     /gene="raiA"
                     /locus_tag="VHC05_001034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HEQ5402352.1"
                     /translation="MIKFSIRGENIEVTEAIRDYVESKLTKIEKYFAKDQEIDARVNL
                     KVYRERSSKVEVTIPLDSVTLRAEDVSQDMYGSIDLVVDKIERQIRKNKTKIAKKHRE
                     KVPTGQVFTTEFEAEEVDEIPEVQVVRTKNVTLKPMDVEEARLQMELLGHDFFIYTDS
                     EDGATNILYRREDGNLGLIEAK"
BASE COUNT        10527 a         5796 c         6657 g         9778 t
ORIGIN      
        1 gtcatttgtg tcatataaaa agcgagtcct cacagaacgt ggactcgctt tttatttaga
       61 ttatcactta aggtagatat taaaagtaac taaatggata tgtaataaaa ggtaggtaca
      121 gacaataagt agaggttaga gattaatgag ttgtcttttt atcatcggta gatggatgac
      181 tgccattgtt gtctgtattg gttgaattac ttgtatcatt gctactacta gtatcatctg
      241 aagtcgtttg gctagaagct gttgtcgtgt tattgctgta aagattgttg taaaccgaat
      301 tagtatagtc ggtgttgctc gcataggttc cgcttaagta gaggaatcca ccactgcgat
      361 aaagaccatt tggcatcgtc caatcttcac tgtaaccatt tgttaagtaa gtcatcatgc
      421 tacgataaac gtcagatgca atctctagac ttgatccgta tactggggtc aagcggtttt
      481 tgtaacctgt ccaaacagcc atggcgtagc gcttagtaaa gccaacaaag ttttcgtctg
      541 gcgctaatgt accaacataa tctggataaa ggccgtattt ttcaccaatt ttagctagtt
      601 cctcatcagt gtagttagaa gtccctgttt taccagcttg cgcaacacca ggaatggcag
      661 cagcagtacc tgtaccataa gtgagaacag tttttaacat atctgtcatc atataggccg
      721 tggtttcttt catggcacgt tttccttttt catcaaaagt tttacttgta ccatcactaa
      781 attccacttt attgacatac cttggtttat gataaatacc accatttgca aaagcagcgt
      841 atgcagcggc cattttttca ctacttgcac catatttttt atctgagcta ctgttattac
      901 ttgagatagc gtttgagtag tgcatttcgg gatagttaat acctaaactg cttaagaaag
      961 atcgagcata gtcaagtcct gcggcttcca gtgctcggac tgctgggaca tttcgcgata
     1021 gcataatagc agcttggatt gtcatccatc cgttatatct aaggtcccag ttaaacaatt
     1081 gggtagtggt tccaggccaa taatagactg agtcattagt cgactgagca gtagaagtat
     1141 aaacaccaga ttcaatagca ggagcatagg ctgtgattgg cttcatggta gaaccccagt
     1201 cacgatcagt taaaacagcc tggttagtcc caaatgaaac attttcatct tgattacgtc
     1261 cgccaagctg agcaataaca tgaccatttg tcacatcaac aatcgttgaa gcaacttgga
     1321 aatcttggtc tggatagtaa acataatcac cagaatgata aatattataa agagtctgct
     1381 gcgcatcggg gataatattg gtataaactt ttaaaccagc ggtaaaaata tctttattcg
     1441 tttctttttt gacttcttca ataacttgtt ttagataatt atccatatat tttggataag
     1501 ttgagcgctg ttggagtgat tgtagacctt cagcgacggg agttgcgatg gcagtttcat
     1561 attctgcttt cgtcagatgt ttttccatgt acatctgttg caacacgacg ttacggcgat
     1621 tttgagcagc ttcaggatga aggtaaggat catattgact aggagcttga gggattccag
     1681 ccaatagggc tagctgggca taagataaat ccttaagatc cttgccataa taagacttag
     1741 cggctgtcag cataccatag ttgccattac ccatatatac tttgttgatg taaaaagtca
     1801 ggatttcttg tttagtatat tttcgctcca tttgaagagc aagccaaact tcttgagcct
     1861 tacgttttaa ggtttgatca gattcattag tagaaaaata ggctagttta atgagttgct
     1921 gatcaagcgt tgacccccct tgagtggtct gactcgttag attatgaaag gcagcaccaa
     1981 aaatacgata aagatctact ccacgatggt taaagaaacg tttatcttca attgaggtaa
     2041 tagcattaac tagattaata gggatactat cagctgttac attttcacgc ttttcagaac
     2101 ccaaatcagc aatcagattg ttattaccgt cataaaccaa gctagagttt gttgatttta
     2161 actgggcttc tgacagtttc ggagcactgc taatgtagaa ggtaaacaaa agaccaccaa
     2221 taataataac aaggataata aggctaagaa ttgcacttaa tacatacttt agccacttaa
     2281 ggatttttgg atttttaatt gtaatcaccg cctaaaaaat tttgttcaat tatgtttaaa
     2341 taagggactt gtggaaaggc tccgaatgct accttaaagc cattttttct gatataatca
     2401 atgggcatcg atttactgcc attatctatc tgataaaatg aaatcaaggc ttgagcaggt
     2461 aggtagtaag tctccttcag tgtggaaaag tgaagaagga caaagcagat tcctttttga
     2521 tgtaaaacgc aagccatatg ttcaatctga tgtaaatgga aatttttcat gggcatagct
     2581 gttttttgcc tggtttcttt tgcttcaaaa tcaacataat gtcctttata aacgccgcaa
     2641 tagtcagtcg ttgaagcttg tctaaagtac gcttcaacga tttttgcccg actgcgttta
     2701 gggtaatcca ctttgacaat ttggacagga gtaggttttt tgtgaatgac agctatttga
     2761 cgagataaat aataatcatt tgtcgcgttg atagcagctt caaaggacat acctctattg
     2821 gcgaagtcca ccttattttg ctttgtttgc ttttgaacgg aacttacttt ttgtcgaata
     2881 agattatgag gataattaac cattgttctc ctaatattat ctagttaatg ctaaaaattt
     2941 aagcactttt attataacat attttttgaa aggataacac ctaatgactg cgattctaat
     3001 tacaggttac cgaagctttg aaatagggat ttttgaccat aaagacccac gagtttcaat
     3061 tattaaacag gctattcgta aagatttaat aggttatttg gaaaacggtg tggattggtt
     3121 tatctttaca gggaacttgg gttttgaaca atgggctttg gaagtagcta atgagctaaa
     3181 agaggagtat cccttgcaga tagctactat attcttgttt gaaacgcatg gagataggtg
     3241 gaatgaaaaa aatcaagaag ttttaagtca gtttagggct gttgactttg taaaatatta
     3301 ctttccaaat tacgaacaac cgacgcaatt tagtcaatat tatcagtttt tattagaaaa
     3361 gacagaaggg gcttatgttt tttatgacac agaaaacgag accaacttaa aatattttct
     3421 caagaaagca aaagatatgc cgcattatca gttgctattg ctaacctttg atcggctaaa
     3481 tgatatgtca caaagctagc attgtatttt taggggtatt ggtatttaaa tacttgcttt
     3541 ttgaactatt tttctgtatc attaataata atactgaaat ataattttgg taaaaagatt
     3601 gaccgttcgg agagtaaaga atgacaagta ttatttatag tcctaaagat atttttgagc
     3661 aagaatttaa gactagtatg cgagggtttg ataagaaaga agttgatgaa tttcttgata
     3721 atgtaattaa agattatgaa aatttcaatg ctcaaattga agctttaaaa gctgagaacg
     3781 aagccttaaa aaaggcgaag tttcaagcta gaaatacagt ttcagcgact gttcaacaac
     3841 cagtaccgca accgactcgt gttgctcaat cagctactaa ttttgacatc ttgaaacgta
     3901 ttagtaaatt ggaaaaagag gtttttggta aacaaattat tgagtaatga aaactgtgca
     3961 atttttggat aatcgcgtag tattttaata ctatgaggaa agtccatgct agcactggct
     4021 gtgatgccag tagtgattgt gctaggcgaa cacataagcc tagggatgtg catacacatt
     4081 acggcgaagg aaatggctaa gtcgtttgat atgccaaagt acttctgaaa gtgccacagt
     4141 gacgtagttt ttatggaaac gtaaaaaatg gaacgcggta aacccctcaa gctagcaacc
     4201 caaactttgg taggggcatg ggatagttgg aaacgaacaa gctatcctga ctgtcaacag
     4261 acggtagaca gatgattatc gaaggaaata attcctagtt atttccggaa caaaacatgg
     4321 cttatagaaa attgcataat aggttaagct agcacttgct agcttttatt tgatttaaaa
     4381 gaaagagata tatgaaagaa acatttagat tagtcgcaac tgcagccgca ggtttagaag
     4441 ctgtcgttgg taaagaagtc agagcactag gttttgattg tcaggttgaa aatgggaaag
     4501 tttattttga aggtgatgta gaagcgattg ttaaaacaaa tctttggtta cgtgcagcag
     4561 atcgtatcaa aattatcgta ggacaatttc ctgctagaac ctttgaagaa ttattccaag
     4621 gtgtctttgc cttggattgg gaaaattatt taccgctagg agctaaattt ccaatctcaa
     4681 aagccaaatg tgttaagtct aaattgcata acgagccaag tgttcaggcg attaccaaaa
     4741 aagctgttgt taagaaactg caaaaacatt tccacaggcc agaaggagtt cctcttcaag
     4801 aagttgggtc aacgtttaac attgaggtat ctattttaaa agaccaagcc actattatga
     4861 ttgacacgac aggatctagc ctatttaaac gagggtaccg cgttcaaaag ggtggggctc
     4921 ctattaaaga aaatatggca gctgctattt tggcattatc taactggttt ccagataaac
     4981 ctctggttga tcccacctgt ggatcgggaa cgttttgcat cgaggcagcc ctgattggga
     5041 tgaatattgc tccaggattt aaccgttcgt ttgcttttga agaatggagc tgggtagata
     5101 aagacatggt gcaacaagtt cgtgatgatg ccgaacaaga agctaattat gaaatcgaat
     5161 tagatatttc tggctttgat atcgatggcc gcatgattga gattgctaaa agtaatgctg
     5221 aagaagctgg tttatctgat gtgattacct ttaagcaaat gcgtctgcaa gactttcgaa
     5281 cagacaaggt taatggtgta gtgatatcaa atcctcctta tggagaacgg ttgcttgatg
     5341 acaaagcggt tgacatcttg tataatgaaa tgggacaaac ctttgcacca ttgaaaacat
     5401 ggagcaaatt tatccttaca agtgatgaac tttttgaact aaaatacggg caaaaagctg
     5461 ataaaaaacg taaactttat aacggcaccc taaaagttga tttgtaccaa ttttatgggg
     5521 aaagggtaaa gcgacatctg atatagagag gtagtaagcg tgtcagaaga aagcaaagaa
     5581 gtcgaagtaa caaaagaatc gcaaacattg gggcttaatg aagccaagtc aatgacaatt
     5641 ggtgaagctg tacgcaaaca gtcagagata aaagcaggtg ttactaagga tgatagtatt
     5701 ttagataagt acattaagca acaccgtgac gaagtttctt ctcaaaagtt tgatgctaag
     5761 tatacagagc ttgatacagc tagtttagat aactttatca aaaaacaaag agaagcattg
     5821 agtaaagccg gtcttgttga tgacgaacct gtgtctgcgg agtctgctga gcaagatagc
     5881 actttggttg aagaagtagc tgaagactta gctccaatgg agactactgc ggtggtaact
     5941 gggattccgg tggaagcgac agtccctgtg ttagatctag atccatcaga gagggtcatt
     6001 ccggaaccac agataaccaa agaagagcca aaaagagatc agtttctttc tgaagatagc
     6061 caccatccag ccaaacaaaa cacgaaaaaa ggttggttaa tagctttatt tctactatta
     6121 ttggccattc ttgcagttgt atttggttgg aaccatttct tgagacaaga cagtggtaaa
     6181 acaactcaaa cagcaagtaa acagacaaag acctctttgc agaccgacag tgctaaaaaa
     6241 gcaacgcgct tgaaggctgc tgctaaagct ttcgaaaaac aatatggtac tttttataca
     6301 gatgccacaa agagcaaatt aaaaaatagt gcctttgcta ctttgccaga tttagaagct
     6361 gccttgaaag ctttggaagg ctctgcttac tatgataagg cgaaagcaaa agtcgattcc
     6421 cttaagaaag ctattgctgc tattacagcg gttaacggta aatttgtttc cgatgttgtt
     6481 gtagatggtg aaaaggtttc ggctgaagtc aaggctgatg ctaattttga tgatttatca
     6541 agtgcaacct tgacaacagg aaatgcaaat cttgatgctg tcttgcaggc aagcatcaca
     6601 gaaggtcgtc agcaactagc cagcaaggct gaggccgcta aagcagctaa tgagcaagaa
     6661 gcccaggatc aagcagctca aggacaaagt acatcagtag caccatctgg ctatggcttg
     6721 acaagttatg atcctgcaag cttacaacgg catttatcac gtgtacctta caatcaagat
     6781 gttattgctg acagagctaa cccatcttgg gcatttaatc caggagttct tgaaaaaatt
     6841 gtagcaacct cacaagctag aggttatatt tcaggcaacc aatatatttt agagccggtt
     6901 aatattatta atggcaatgg ttactataat atgtttaagc ctgatggcac ttatctgttc
     6961 tctattaatt gtaagacggg ttattttgta ggaaatggca aaggttatgc tgatgcttta
     7021 gattactgag aaaatcaaaa aaactgagat aaggcaactt gtctcagttt tttgattaat
     7081 aaagtatgtt gtcttaaaat ctgcagatag acttgttttt tgtaacaagt caaataggtc
     7141 agtaggattg ttatgtttga caacacacta gtatcagatg acatggcgac taaaaggatc
     7201 gtctgaaatc ccttgatcaa taatcaattg agcccattct ttggcggcaa aaaggttatg
     7261 atccttatag tttccacagg attcaagagt tgttccagga acatcttccc aagtaatccc
     7321 agttgcaatt tcttctaggc tagatttaat caccttggca atatcagtag aactgtgttt
     7381 tccccacatg ataaggtgaa aacctgttcg acagccaaaa ggagagcaat caatcatccc
     7441 atcaatgcgt tggcggatga gcttggcaag taagtgttca atggtatgca aaccggctgt
     7501 ttcaatagaa ttttggttag gctgtactag gcgaacatca aaatttgtaa tacgatcgcc
     7561 cttgggtcca aattcttcag aaataagacg aacataaggg gcctttacaa tagtatgatc
     7621 tagctcaaaa ctttcgacga taacttcttt tgtcatttca atctcctttg ttttacactt
     7681 tatcataaca caaatagtga gaaagtggct acttgtggag gagaaaaggc taagaaaaca
     7741 gatcaaaggc tatcacaatg acctgtgcga taaaagtact tacagaaaca gtaataaagg
     7801 tttctttaaa agcatttttg tggttaagtc ctgtcaatgc taagaaggtg agaaagacac
     7861 cactttgggg cacaatggta aagatattcg aagcaatagt ggcaacacgg tgaatcattt
     7921 cgggattaag gccttgatct aaataatact gggcaaagtt aggcatgaca attcctagag
     7981 cacctgaaga agaaccggta atagctgaca tagaggaagt caacacggct aaactaataa
     8041 gaggattacc gggaatattc aaaatgagat ctgagaagaa tgtgaaacct ggggcaatca
     8101 tcacaacggc tccgaaggca actgcagatg ctgtcgcaaa aataggtgca atagagctgc
     8161 tagctcctaa attaaagaca gcaatcttat taggaataaa ctgtctaaag agccagcttg
     8221 cggtgagaat ggcagctaaa agtgctatga aaataatgtt cttcttaaaa aaatcgtttc
     8281 cgaaaaggct accggttagg gcgataataa tgagcaacaa taaaggtaag atactggcaa
     8341 ggaaatgtgg gagatttttt gttttcactt gtatctcatt gtcaaaagca taagtggcat
     8401 aagtttcacc ccttgccata ctttttgcta gacaatattt catataaaag agcccaaaag
     8461 tcacgcagcc aattgagcca acgatactcg gaatggcggc agcagttagt gaggtgtcca
     8521 agtattgaat aggaataaca ttttgaatgg caggtgttcc gggtaaaatc gtcatggtaa
     8581 aagtcgcaat accgagccaa agaggaactt gaattaagtt ccaagccaag tccatttttt
     8641 tgaataggct tcgtgcaagc ggcaagacag caaacatgac aacaaagagg ctgattcccc
     8701 cgtaagttaa tatagcactg atcagaaaaa tagcaacgag tactttataa ggactatcat
     8761 gaccaacttt ttttaaaata taatctgcaa tagaagtggt tgcaccgctt gtttccatta
     8821 atttggctaa gatagaacct aataaaaaga tagcaaaata attgagaata taagtggaga
     8881 gtgcccccat aaattggttg ggttcttttc caagtaaggt tgtggttgga tccatttgat
     8941 taaacaaaat gaccaagctg gtagcaagag gcgcagcgat gataatgtta acttctttca
     9001 cagacaggta aataataaca ataacaccta ccaagacccc gagagaacca ataatttcca
     9061 tagttttatg acctccttat tagaaaataa agagacagat cacaagatac agcctcttta
     9121 tctctccaaa tttattgagc agtgtagcca ccgtctaaga tacaggcttg acctgtaaca
     9181 ccttttgcct tatcactggc aaggaaagac acatagtctg caatttcttg aacgtcaatg
     9241 aggcgttttt gaggaacaag tgggtataga acttcttcaa gaacattttc aaggggaata
     9301 cctcttgttt tggaaaggtc ttcaaactgt ccacgaacca gtggtgtgtc aacatatcca
     9361 ggacaaatgg cattgaccgt aatgcctgaa tcagcagctt ctaaggcagt tactttggtc
     9421 agaccgatca agccgtgctt agctgaattg taggcggatt tgccagcaaa accaatgaca
     9481 ccattgatag aagccatatt aataatacga ccgtgttttt gagctttcat tgtaggaaaa
     9541 gcacgtttaa tggcaataaa tggtgctgtc aacatgattt taatcatgaa ttcaaatttt
     9601 tcagttggaa aatcttcaat catggcaaca tgttgaaggc ctgcgttgtt aaccaaaata
     9661 tcaatacgac catatttttc aacaaccgta tcaatagcag cattgatggc ttcttctttg
     9721 gtgacatcgc acacaacact aaaagcgtca tagccttctt tagtataatc agcaacaacc
     9781 tgatccagtt tttcttgatt aatgtcagaa aaaacaaccg ttttaccttc ttttaataag
     9841 gtttccccga tttgttttcc aattccgctt gcagcaccag tgataaatgc aacttcttta
     9901 gtatgtgtca tgatactatc ctcgtctttc ttttggttag tctttagttt gttttatcaa
     9961 ttagggtaac ttcggtaacg ttttgcacgt cttcaaaggt gtaatcgggg ttaatttcaa
    10021 gggcgcatag accttcatct tgatattcaa agactcccat ttcagtaatg attaggttaa
    10081 caacattttg agcagtcaga ggaagggtgc atttgtctaa aatttttgct ttgcctttat
    10141 tggtatgctc cattgcaaca atcacttttt tagcacctac caataagtcc atggcccctc
    10201 ccatcccagg aaccattttt ccaggaatca ggtaattagc aatgctagct tctttatcaa
    10261 cttgtaaggc acctaagacg gttgcggcca catggccgcc tcgaataata ccaaaggaag
    10321 ttgagctatc gaagaaagcc cctccaggag caatactaac aggttgccca ccagcattaa
    10381 caatagtagg atcgtagtga tcatctgtta atccagtgag accgacaaaa ccattttcgg
    10441 actgcagggt aatggttacg cctttaggaa tatagttggc tacttttgtt ggcaaaccta
    10501 tgcctaagtt gaccagtgta ttgtgttcta attcttgtgc aacgcgctta gcaatacgtg
    10561 tttgaatctc ttcttttgaa agaacagtag ctgatgttcc catgttaggc tcctttcact
    10621 aagtagttaa caaaaatgcc aggagtatgg acaaaattag gatccatttg ccccacgtca
    10681 acaatttctc ttgcttcaac aatggtggtt ttcgcattag cagccatcac atgattaaag
    10741 ttattttcag aacctgcgta ttgcaaattg ccatttttat ctgccttgtt agcaaaaata
    10801 agtgcgacat cagcttttaa aggcgtttca agaaggtaat ctttgccgtc aatagtaatg
    10861 acttcttttc ctttggcaac ttcggttcct attccagtag gtgttaagaa accgcctagc
    10921 ccaaaaccgc cactgcggat gcgctcagct aatgttccct gaggtacaag atcaattaca
    10981 gtctcgccct cagtcatttg tcggcccgct tcacggttga gaccgatatg tgatgcaata
    11041 atagttgaaa actgtttatt ggcaaccatc ttaccaacgc ctttgtcagg aaaaccggca
    11101 tcgttacaga ttaaagtgag gtctttgaca cctttttcca caagtgcatc aattaatttt
    11161 tctggtgtgc catttgtcat gaagccacca accataatgg tatcaccatc tttaacgtga
    11221 gctaccgctt cttttattgt gatttcttta cacatttttt ctaccaactt tcacgagact
    11281 aagtattgtt tttcacgata acagcagttc cttgtcctcc accaatgcaa agtgttgcta
    11341 gtcctctggt tacttggcgt tttttcattt cgtggattaa tgtgactaga atgcgagcgc
    11401 cactggcacc aataggatga cctaaagcga tggctcctcc attaacattc acgatttctg
    11461 ggtttaactt taaatctttt aaaaccgcca aggactgtgc tgcaaatgct tcattggact
    11521 ccactaagtc caaatcagaa attgttaatc cagctttctt aaggactttt tgagtggcag
    11581 gaattggtcc agctcccatc agttcaggtg caacacctgc actagcatag ctttcaatag
    11641 tgactaaagg tgttaaccct aattcaagag ctttttcttc agtcattaac atcaataagg
    11701 ctgcaccatc gtttattcct gaggcattcc cagcagtaac ggttccttct ttagggagga
    11761 aggcaggacg taattgctgt aatttttcaa ggcttgtgtc aacttttggg tattcatctg
    11821 ttgtaacaat taaagggtct ttgcgtcgtt gaggcacaga gacagggaca atttcgtcag
    11881 caaaacgatg attttctaat gccttagcag ctttttcttg gctttctaaa gcaaattgat
    11941 cttgctcttc tcttgagatg ccatatttct gagcaacgtt ttcagcagtg atacccatat
    12001 gataattgtt gaaagcatct gtcaatccat catgaacaag agtatcaatc aattgactat
    12061 taccaagtcg ctgtccaaaa cggtgctgag ttgacacata ggctgcctgt gacatgtttt
    12121 cgacaccacc agcaataacg atatcagcgt caccaagcat gatgctttgc gtagctaatt
    12181 ggattgcttt aagtcctgaa ccacagacca tatcaagcgt gaaggctgtt ttatcactag
    12241 ggatgccaga gtgaatagca atctgtctgg caacgttttg ccctaatcct gcatgaagga
    12301 cgtttcctag gatgacttca tcaaccattt caggctttac ttgcgtttta tcaaggattt
    12361 ttttcagtac agttgttcca agttcaacag cagagacact tttaaaggag cctccaaaag
    12421 ctccgatagg agttcgtaaa gcttcaacga taactatgtt tttcataaaa taaacatcct
    12481 ttcattttta gaaagcgttt tctgtatctc taagataaca agaaaccgct caaaataaaa
    12541 atatagaatt tttataagca tataaatttt tttgatagat ttggcaatag caattaaaaa
    12601 tcacttatgt cataatggaa ttaatactat cggaaaaaag actaatagac aaggggataa
    12661 ccatttggat attaaacaaa ttcgttattt tatcgcaatc gttgaaaatc attttaactt
    12721 gagccaggcg gcggaactgt tgtatgtgtc gcagccgaca cttagcatga tgatcaatga
    12781 ttttgaaaaa agggaaaatg ttaagctctt caaacgaaaa agaggtcgta ttattgggtt
    12841 aacctatctt ggtgataatt attataagga cgctcaaaag gttctcagtc tctatgatga
    12901 catgtttttg aaattgcatg atcacagtaa agggttaaag ggaagtatca atattggtat
    12961 tcctcctctt attttatcag ttgttttctc agaagtaatg ccaaaactga ttttagaaaa
    13021 tccgggaatt caattcaatg ttaaggagat tggtgcttac caactaaaaa atgaactact
    13081 cgtgggaaat gttgacgtcg cagtcttgtt atccccaaca ggcatcgctg ataatttggt
    13141 tgagacttat gaaacccaga gatcagaatt atctgtatgc ctgtctccac gtcatcgttt
    13201 agcttccaaa aaagttattc agtgggaaga tttaacagat gaacaacttg ccctatttga
    13261 tcctagtttc atggttcacc atttagtgct tgaagcttgc gagcgtcacc aagtcagacc
    13321 taatattatt ttgacgtcct cttcctggga ttttatgctt aattctacca agattaatca
    13381 caacgtctta actatttgtc ccaaacctat tacagaatta taccaattaa aggacattaa
    13441 gtgtattcca atggaacgtc ccatttcttg gcgtgttgtc ttaacacgcc tccggaaaaa
    13501 aagtaattct gaaatagaag cctacatcat ggacgacttg ctacagtctt tttttaagta
    13561 gggttctcaa ccacttggcc cagatgttaa tttttttaaa aatgaattgg aattgtgtaa
    13621 acgctcaatt tatgataaac taagaggtag ctttctatta atgaaatcta gaatatattg
    13681 aggtacaaac atggttaata ttattttatt aattgtttct gccctcattg gtttaatatt
    13741 aggttatgca cttatttcga ttagactcaa gtctgcgaag gaagctgcag agttgactct
    13801 tttaaacgct gaacaagaag ctgttgatat tcgtggcaaa gcagaagtag atgctgaaca
    13861 catcaaaaaa acagctaaac gtgaaagtaa agcaaatcgt aaagaattac ttttagaagc
    13921 aaaagaagag gcaagaaaat atcgtgaaga gattgaacaa gaatttaagt ctgaaagaca
    13981 agagcttaaa caactcgaga cacgcttagc ggagcgctcc ttaactcttg accgtaaaga
    14041 tgaaaaccta tcaagtaaag aaaaggtact agatagtaaa gaacaaagtc tgaccgataa
    14101 atctaaacac attgatgagc ggcaacttca agtagaaaaa cttgaagagg agaaaaaagc
    14161 agaactggaa aaagttgctg cgatgacgat tgcagaagcg cgtgaagtga ttttaatgga
    14221 gacggaaaac aaactgaccc atgaaattgc gacgcgcatt cgagatgccg aacgtgacat
    14281 caaggaccga acagttaaaa cagccaagga cttgttagcg caagccatgc aacgccttgc
    14341 tggtgagtat gtgactgaac aaactattac cagtgtccat ctcccagacg acaacatgaa
    14401 gggccgaatt attggacgtg aaggccgtaa tattcgtact ttagagagct tgactggcat
    14461 tgacgttatt attgacgata ctcctgaagt tgttatctta tcaggatttg atcctattcg
    14521 acgtgaaatt gctcgtatga ccttggaatc tctgattgct gatggtcgca tccatccagc
    14581 tcgtatcgag gaattggttg agaaaaatcg tcttgaaatg gataatcgta ttcgtgagta
    14641 cggtgaagct gcagcctatg agattggtgc accaaacctt catcctgatt tgattaaaat
    14701 catgggacgc ctgcaattcc gtacctcgtt tggtcaaaat gtcctacgtc actctgttga
    14761 ggttggtaag ttagctggta ttttagctgg tgagttaggt gaaaatgttg ctcttgcccg
    14821 ccgtgctggt ttcttgcatg atatgggtaa agctattgac cgtgaggttg aaggtagtca
    14881 cgttgagatt ggaatggaat ttgcacgtaa atacaaagaa catccagttg ttgtcaacac
    14941 tattgctagc caccacggag atgtggagcc agattctgtg attgctgtgc tagtagctgc
    15001 agcagacgct ctcagttcgg ctcgtccagg cgctcgtaat gagtcaatgg agaattacat
    15061 caagcgtctt cgtgatttag aagaaatcgc gacaagtttt gatggggtac aaaatagttt
    15121 tgctctacaa gctggacgtg agattcgtat tatggttcaa cctgaaaaaa tttcagatga
    15181 tcaggttgtc attttgtcgc ataaggtaag agaaaaaatt gaaaacaatc tagattaccc
    15241 aggaaatatt aaagtaactg ttattcgtga gatgagagcg gttgattatg ccaagtagaa
    15301 aaagaggaat tatcctcttt ttctttatga cttgcctttg aaaatgttct tgaaaaagac
    15361 tagccttttt gataaactat taaaaagcaa ctaataagga gaatacaatg tctgaacgcg
    15421 gtttgttaat cgtcttttct ggcccttcag gtgtcggaaa aggaacggta agacaagaaa
    15481 ttttttcaac gccagatcat aaatttgaat attcggtttc aatgacgact cgtccgcaaa
    15541 gaccgggcga ggttgatggg gttgattatt tcttccgcac acgtgaagaa tttgaagaac
    15601 tcattaaaac tggtcaaatg ctagagtatg ctgaatatgt tggtaattac tatggcaccc
    15661 ctttaactta tgttaatgag actcttgata agggaattga tgtcttttta gaaattgaag
    15721 ttcaaggagc tcttcaggtt aagtcaaaag taccagatgg tgtttttgtt tttttaacac
    15781 caccagattt agatgaatta gaagaccgcc tggttggtcg tggtacagat agtcaagaag
    15841 tcatagctca acgtattgaa agagcaaaag aagaaattgc ccttatgcgc gaatacgatt
    15901 atgcagttgt taatgatgaa gttgccttgg cagctgagcg ggttaagcgt atcattgaga
    15961 cagaacactt tcgtgtggag cgcgtgattg gtcgttatga taaaatgatt aaaataacaa
    16021 aaaatccctt taaagctaaa tagaaaagag taagcattat gatgttaaaa ccttccattg
    16081 ataccttatt agataaagta ccatccaagt attcacttgt gattttacaa gccaaacgtg
    16141 cccatgaact agaagctggt gccactccaa ctcaagaatt taaatcagtg aagtcaacac
    16201 ttcaggcact tgaagaaatt gaatcaggaa acgttgtgat tcacccagat ccttcagcta
    16261 aacgtgaagc tgtccgtgct aagattgagg cagaacgctt ggccaaagag gaagaggaac
    16321 gtaaaatcaa agaacaaatt gccaaagaaa aagaagaaga aggagaaaaa atctaaggtt
    16381 tcagaaatct tagatttttt catatttagt acgatgtcca tgacagaaaa ggagaagcaa
    16441 atggaaaaag tagctcatgt gattgtagat attccattga tgcaaacgga caagccattt
    16501 tcttatggta ttccaaaaga gttagtttct ctcgtgcagc ttggttctcg tgtgcatgtt
    16561 ccttttggaa aagggaatcg tttgttgcaa ggctttatta ttggttttgg ccaagaagat
    16621 tcaagctctc ttaaactgat tcagaccgtt ttagatcctg agccagtcct aaaccaagaa
    16681 caattgaccc ttgctgatca gcttcgaaaa acagtttttt cttataaaat cacgctctta
    16741 aaagcaatga ttcctaatct tcttaactct aactatgata aagtgctaag gccagagtca
    16801 ggtctaaaaa agtctgatag ggactttctt tttgaaggaa aaccatctgt cttatattct
    16861 accttagacc gcgagaaggg aaaaatagct cttaagggca tacaagctgg gcatattact
    16921 gttagttatt tagccaaaga caagaaaaac ctaaagacag aaaaatatta tcacgtcgac
    16981 ttagacgcct tagcggtaca tcccatctct agtcgtgcca aaaagcgtca attattaaaa
    17041 gactatctgc taacccatac gaaggaagct aaacttgcaa cgctttatca agccttttct
    17101 agagatgtgg tgacttactt tgtgacaaat cacttaattc gtattgacga acgtccaatt
    17161 gatcgcagtg agtcctattt tgaccagatc aaaccatctt cttttttaac cttaaatgaa
    17221 cagcaggcgt cagctgttac tgaaattgtt gaacaaattg ggaaaccgag taaacctttt
    17281 ttgattgaag ggattacagg ttcgggtaag acagaagttt atcttcatat catcgaagcg
    17341 gttttaaaac aggataagac agccattgtt ttagtgccag aaatttcgtt gactcctcag
    17401 atgacctctc gttttatttc ccgtttcgga aagcaagtgg ctattatgca ttcaggctta
    17461 tcagatggtg aaaagtttga tgagtggcgc aagataaaaa caggacaggc taaggttgtg
    17521 gttggtgccc gctctgctat tttctcccca ctagagcgga ttggtgcaat tattatcgat
    17581 gaggagcatg aatcaaccta taaacaagaa agtaatccac gataccatgc tagagaggtt
    17641 gccctgctca gagctaaaca ccatcaagca gttgtggtta tgggctctgc tacgccaagt
    17701 attgaaagcc gagcaagggc tagtaagggt gtctatcatt ttattcaatt aacgcaaaga
    17761 gcaaaccctc tcgctaagat tccagaagta acgattgttg attttcgtga ttatattgga
    17821 cagcaagcag ttagtaattt taccccatat ttgattgata aggttaaaga acgtttggtt
    17881 aaaaaagaac aagttgtctt aatgttaaat agacgtggtt attctagttt tgtgatgtgt
    17941 cgggactgtg gttatgtgga caaatgtccc aactgtgata tctctttaac ccttcacatg
    18001 gatactaaaa ctatgaattg ccattactgt gggtttcaaa aacctatccc aattacttgt
    18061 cctgagtgtc atagcaatag tatccgctat tatggaacag ggacgcaaaa agcttttgat
    18121 gaattgcaag gggttattcc agaagctaag atcttgagaa tggatgttga caccacacga
    18181 aaaaaaagaa gtcacaaaac catactagat agttttggtc gccaggaagc agatattttg
    18241 ttagggacgc aaatgattgc caaaggactg gattttccaa atgtgacttt agttggggta
    18301 ctaaatgcag atacctcctt aaatttgcca gattttcgag cgtcagaaaa aacgtttcaa
    18361 ttgttaacac aggttgctgg tcgggcaggc cgtgcccata agccagggga agtcttgatt
    18421 caaacttata atcccgatca ctatgcaatt cagttggcta aacaacaaga ttttgaagcc
    18481 ttttaccgtt atgaaatggc gattcgccgt cagatggctt atccccctta ctactttaca
    18541 gtgggtatta cgctttcgca tcgtttagaa gcatcggttg taaaaaaagc ttatcaagtt
    18601 acagaactgc taaagagtca cttatcgaat aatattaaaa tattaggacc gactcctaag
    18661 ccaattgcta gaacacacaa tttataccac tatcaaattt tgttaaaata ccgttttgaa
    18721 gataacctag aagagacgct caatcgtatt cttgattgga gtcaagaagc agataatcgt
    18781 catttaaaac taattattga ttgtgaaccg caacaatttt tataaggtaa atcactaaat
    18841 ctaggatgat cagttatgat ataataaaaa tacaaagagg aaagtcatga taaaattatt
    18901 atttatggga actccccaat tttcagcaac tgtattgaag ggcttgctag ataatcctgc
    18961 ctatgagatt ttaggagtgg ttactcagcc tgatcgagct gttggacgca aaaaagatat
    19021 taaggtaaca cctgtaaagc aattagctct tgagcatgga atatcaatct atcagccgga
    19081 aaaattatca ggctctcaag aactcattga gattatggga cttggtgcag atggtattat
    19141 tacagcagca tttggccaat ttttaccaac actattactt gattcagttt catttgctat
    19201 taatgtacat gcatcattgt tacctaaata tcgaggtgga gcacctatcc attatgctat
    19261 tatgaatgga gataaagagg ctggcgttac tattatggaa atgattaaag aaatggatgc
    19321 aggtgacatg gtcgctaaag caagcactcc aattcttgaa accgataatg taggtactct
    19381 ttttgagaaa ttagccatca ttggtcgaga cttacttttg gatagtttgc cagcttatct
    19441 ttctggagaa ttaaaaccta ttcctcaaga tcacagccaa gctacttttt cacctaatat
    19501 ctctccagaa caagaaaaat tagattggac aatgtctaat caagaagtgt tcagtcatat
    19561 tcgaggtatg aacccttggc cggtagcgca tacgttttta gaggggcaac gtttaaaaat
    19621 ttacgaagct caactagctg aaggagaagg attacctgga caagttattg tcaaaaccaa
    19681 aaaatctttg gtaatagcta ctggacaagg agctttgtcc ttgatcgttg tgcaaccggc
    19741 tggtaaacct aaaatgtcaa taatagactt tttaaacggc attggtagaa aacttgaagt
    19801 aggggacatc attggcagat aattggaaaa aaagtacgcg aggcaaagcc ctccttgtca
    19861 ttgaagctat ttttgatcag ggggcttaca caaacatagc gcttaatcag cagctaagca
    19921 gtaaagcttt atctgctaag gacagagctc tattaactga gattgtatat ggtaccgttt
    19981 cacgtaaaat tagcttggaa tggtatttag cccattatgt caaagaccga gataaattgg
    20041 acaaatgggt ttattatctc cttatgctca gtctttatca actgatttat ttagataagt
    20101 taccagcgca tgccattgtt aacgatgcgg ttggtattgc caaaaatcgt ggcaataaaa
    20161 aaggtgcaga gaagtttgtc aatgctattt tacgtcaatt caccagccat cctctcccag
    20221 atatggaaac aattaagcgt cgaaataagt attattcggt caagtattca ctgcctgttt
    20281 ggttggttaa aaagttagaa gaccaatttg gctccgacag agcagtggct attatggaga
    20341 gtttatttat gcgtagtaag gctagtactc gcgtgacgga ccctttgaag ttagaagaag
    20401 ttgctgaggc tttagatgca gaacgttccc ttttatcagc aactggttta accaaagcgt
    20461 caggtcattt tgcagccagt gattatttca caaatgggga catcactatt caagatgaaa
    20521 gcagtcagct tgtagctcct actttaaaca ttgacggtga cgacataatt cttgatgcgt
    20581 gcagcgctcc agggggtaag acctctcata tagcatctta cttaaaaaca ggtaaagtta
    20641 ttgccttaga tctctatgat cataaactag agttggtgaa ggaaaatgct aaccgcttag
    20701 gagttgctga taacattgag acaagaaaac tagatgccag agaggttcat cgtcattttg
    20761 aaaaggatag ctttgataag attttggtgg atgctccttg ttcaggaatt ggtttgattc
    20821 gtcgaaaacc cgatatcaaa tataataaag aaagtcaaga ttttaatgct ctacaggcta
    20881 tccagctaga gatattgtct agtgtttgtc aaaccttgcg taaaggtggt ataataacat
    20941 acagtacttg cactattttt gatgaggaga atcgtcaagt catcgaagca tttttacaga
    21001 gtcatcctaa ttttgaacaa gtaaaactga accatacaca agcagatatt gtcaaggatg
    21061 gttatcttat tatcacacca gaacaatacc agactgatgg cttctttatt ggacaagtca
    21121 gacgagtctt gtagtatttt aggaggaaac tgactgagtc agaaaaaacg tatgaagatt
    21181 tcattaaaaa cagacattgg gcaaaaacgc tcaaacaatc aagattttat caataagttt
    21241 gataataaaa aaggcatcac tttagtgatt ttagcagacg gtatgggtgg ccacagagct
    21301 ggaaatattg ccagtgagat gacagtcaca gacctgggaa gagaatgggt aaaaacagac
    21361 ttcacagagt taagtcagat tagagattgg ttatttgaaa ctatccagtc agaaaatcaa
    21421 cggatttatg atctaggcca atcagaagac tttaaaggaa tgggaacgac tgttgaagca
    21481 gtagctttag ttgaatctag cgccatttat gctcatattg gtgattcacg gattggtctt
    21541 gtccatgatg ggcattatac cttattgacc agtgatcatt ctttagtgaa tgagttggtt
    21601 aaggcaggac agatcacaga agaagaagct gctagccatc cacaaagaaa tattatcact
    21661 caatctattg gtcaagcttc cccagtagag cctgatttag gagtgagggt tttggagcca
    21721 ggggattatc ttgtcattaa cagtgatggt ctaaccaata tgatttcaaa tgatgaaatt
    21781 gtgactatct tgggcagtaa ggttagtctt gatgaaaaaa accaagaaat gattgactta
    21841 gctaacctaa gaggaggcct agataatatt acaatcgctt tggttcacaa cgaaagtgag
    21901 gacgtcgaat gattcagatt ggcaaattat ttgctggtcg ttatcgcatt ctgaaatcta
    21961 ttggccgcgg tggtatggcg gatgtttatt tagcaaatga tttgatcttg gataatgaag
    22021 acgttgcaat caaggtcttg cgtaccaatt atcaaacaga tcaggtagca gttgcgcgtt
    22081 tccaacggga agcgcgggcc atggctgaat tgaaccatcc caatattgtt gccatccggg
    22141 atataggcga agaagacgga cagcaatttt tagtaatgga atatgtggat ggtgctgacc
    22201 taaagagata cattcaaaat catgctccat tatctaataa tgaagtggtt agaattatgg
    22261 aagaagtcct ttctgctatg actttagccc accaaaaagg aattgtacac agagatttaa
    22321 aacctcaaaa tatcctacta actaaggagg gggttgtcaa agtaactgat ttcggcatcg
    22381 cagtagcctt tgcagaaaca agcttgacac aaactaattc gatgttaggc agtgttcatt
    22441 acttgtctcc agaacaggct cgcggctcca aagcgacgat tcaaagtgat atttatgcga
    22501 tggggattat gctctttgag atgttgacag gccatatccc ttatgatggc gatagtgctg
    22561 ttacgattgc cttgcaacat tttcaaaagc ctcttccatc tattatcgag gagaaccaca
    22621 atgtgccaca agctttggag aatgttgtta ttcgagcaac agccaagaaa ttaagtgatc
    22681 gttacgggtc aacctttgaa atgagtcgtg acttaatgac ggcgcttagt tataatcgta
    22741 gtcgggagcg taagattatc tttgaggatg ttgaaagtac caaacccctc cccaaagtgg
    22801 cctcaggtcc caccgcttct gtaaaattgt ctccccctac cccaacagtg ttaacacagg
    22861 aaagtcgatt agatcaaact aatcaaacag atgctttaca gccccccacc aaaaagaaaa
    22921 aaagtggtcg ttttttaggt actttattca aaattctttt ttctttcttt attgtaggtg
    22981 tagcactctt tacttatctt atactaacta aaccaacttc tgtgaaagtt cctaatgtag
    23041 caggcactag tcttaaagtt gccaaacaag aactgtatga tgttgggcta aaagtgggta
    23101 aaatcaggca aattgagagt gatacggttg ctgagggaaa tgtagttaga acagatccta
    23161 aagcaggaac agctaagagg caaggctcaa gcattacgct ttatgtgtca attggaaaca
    23221 aaggttttga catggaaaac tacaaaggac tagattatca agaagctatg aatagtttga
    23281 tagaaactta tggtgttcca aaatcaaaaa tcaaaattga gcgcattgta actaatgaat
    23341 atcctgaaaa tacagtcatc agtcaatcgc caagtgcggg tgataaattt aatccaaacg
    23401 gaaagtctaa aattacgctc agtgttgctg ttagtgatac gatcactatg cctatggtaa
    23461 cagaatatag ttatgcagat gcagtcaata ccttaacagc tttaggtata gatgcatcta
    23521 gaataaaagc ttatgtgcca agctctagct cagcaacggg atttgtgcca attcattctc
    23581 ctagttctaa agctattgtc agtggtcaat ccccttacta tggaacgtct ttgagtctgt
    23641 ctgataaagg agagattagt ctttaccttt atccagaaga aacacactct tctagtagct
    23701 catcgagttc aacgtcaagt tcaaacagtt cttcaacaaa tgatagtact gcaccaggta
    23761 gcaacactga attaagccca tcagaaacta cttctcaaac accttaacaa agaatagtta
    23821 gtctcatgtt ttattggcat gccactaact gttcttttta actactcgtc atataaagat
    23881 gcaattttcc aggaattctg ataaaataca aagaaataag gggaaactaa tgaaaaaatt
    23941 tcaattcttt ttacttatcg agtgtatact gctagctatg ggtatcatga caatcttgga
    24001 taatgattta tcaagtttta tcctaattct agttcttatc ttattagcat tacgctttta
    24061 taaccaagat agccgcaata attttttgct aactgtcagt ttattgtttc tttttttaat
    24121 tttcatgctt aatccctaca ttatcatggc tgttcttttg gggatagttt acattttcat
    24181 taaccatttt tcacaagtca aaaagaagaa tcgctttgcc ttgattcgtt tcaaggaaga
    24241 aaagattgaa gtgaataata ccaagcatca atggattggt actgctaatt atgaaagtga
    24301 ttattattgt tttgatgaca ttaacatcat tcgaatctca ggaaatgaca cggttgactt
    24361 aaccaatgtt attgtgacag gaatggataa tatcattgtg atacgtaaaa tttttggaaa
    24421 tacgactata ttggtaccta ttgatgtcac tgttacttta gatgttagtt ccatatacgg
    24481 aagcgttgat ttttttagat gtcagcaata tgatttgcgc aacgaatcta ttaagttaaa
    24541 agaaacggat aaccaatccc ttaaaaaagt caaaattatc gttacaacta ttgccggaaa
    24601 tgttgaggtg gataggcgat gaaaaaacgt tactatgctc ttgtttggct ctactcaacc
    24661 attaccattt tatctattgt ttttgtggtc atggataatt taggaatcac tattaactac
    24721 cttcgcaatc atttatggca ggtcgaacgt ctagggtttt cgattttatt gttgattgtt
    24781 tctgtgactt tattattgtt gttattgtgg attattatgg atgataacag taagcgtaac
    24841 atcaaccaaa atctaaaata tattctcaat aatcgacgac tctatctaga tgagacatca
    24901 gaaatcaata ctaatttaag tcgactttct aaaaaaatgt ctcacctgac tgctaacatg
    24961 caaaagaaag aaagtgctta tattcttgat agccaagaag ttgtaaaaca agagcgcaaa
    25021 cgaattgcaa gagatttaca tgacacagtc agtcaagagc tattcgcttc gtcattgatt
    25081 ttatcaggaa tttcgatgag tttggaacaa ctggacaaaa cacaattaca aacacagtta
    25141 acaacggttg aagcaatgtt gcaaaatgct caaaatgatc tacgcattct cctcttgcat
    25201 cttagaccta ccgagctagc taatcggact ttatctgagg gccttcatat gattcttaag
    25261 gaattaacag ataaaagtga tattgaagtc atttataagg aaaccattgc tcagcttcct
    25321 aaaacaatgg aagataatct ttttagaatt gcccaagaat tcattagcaa cacgttaaaa
    25381 catgctaaag ctagtcgaat tgaagtttat ctcaatcaaa cctcaacaga attacaattg
    25441 aagatgattg atgatggtgt aggatttgat atggatcagg taagggattt gagttatggt
    25501 ctgaagaata ttgaagaccg tgtcaatgat ttagcaggaa acctacattt aattagtcaa
    25561 aaaggcaaag gagtttccat ggatattaga ctgccgatag tgaagggaaa tgacgatgag
    25621 taagataaaa gtgatattgg tcgatgatca tgaaatggtc cgcatgggac tcaagagttt
    25681 tttgaattta caagctgata ttgatgtcgt tggtgaagcc tctaatggac gtgaaggggt
    25741 tgatttggca ttggctttga agccagatgt tttggttatg gatctagtga tgccagagtt
    25801 aggcggtgtt gaggcaactt tagaagtcct aaaaaaatgg aaagaggcta aggtacttgt
    25861 gttaacttcc tatctagata atgaaaagat ataccctgtc attgatgctg gtgctaaagg
    25921 ttacatgtta aagacttcta gtgcagccga aattctaaat gctattcgga aagtttcaaa
    25981 aggtgaattg gccattgaaa cagaggtgga caaaaaaatt aaagcgcatg accaacaccc
    26041 tgatttgcat gaagagctaa ccgcgcgcga gtatgatatt ttacatcttt tagctaaagg
    26101 gtatgataat caaactatag cggatgaact tttcatctcc ttgaaaaccg ttaaaacgca
    26161 tgtatctaat attcttgcta agctagaagt tgatgaccga actcaagcgg ttgtctatgc
    26221 ttttcgacac catttagtcc cccaagacga taattaatgc tataatatag ggtatagcaa
    26281 attggaggaa agtatggacg caaaactaaa atacaaagct aaaaaaatca aaatggtgtt
    26341 ctttgatatt gatgatacct tgagggtcaa agatacgggt tatatgcctg agtcgattca
    26401 aagagtattt aaggctttga aggcaaaagg catcttggtt ggtattgctt caggtcgcgc
    26461 tcgttatggt gttccacaag aagttcaaga tttacatgct gactattgtg tcaaattaaa
    26521 tggagcttat gtcaaagacg atgctaaaac tattattttc caagctccga ttccagcaga
    26581 tgttgttgtg gcctataaaa aatgggcgga tgatatgggc attttttatg gaatggcggg
    26641 tcgtcatgaa gcggtgttgt ccgctcgaaa tgacatgatt agcaatgcta ttgataatgt
    26701 ctacgctcaa ctagaggtct gtccggatta taatgagtat catgatgttt accaaatgtg
    26761 gaccttcgag gacaagggag atggcttgca gttgcctgct gaattagcag agcaccttcg
    26821 tttggtcaga tggcacgata actcatcaga tgttgtcttg aaaggtacgt caaaagcgct
    26881 aggtgtttca aaagtagttg accatttagg attaaaacct gaaaacattt tggtgtttgg
    26941 tgatgaacta aacgacttag agttatttga ctatgctggt atcagtattg caatgggagt
    27001 atcacaccca cgtttgcaag aaaaagcaga tgttatcaca aaaaaagttg aagaagatgg
    27061 cattttatat gccttggagg aattaggatt gattgacaaa gaattacagt ttccacaatt
    27121 ggatttagaa aatcatactg gaccaaaagt aaccattaaa acaaatcatg gggatatgac
    27181 tttggtcttg ttcccagagc attcccctaa gacggttgct aacttcttag gattagctaa
    27241 agagggatac tatgatggca ttattttcca ccgcgttatt cctgaattta tgattcaagg
    27301 tggtgatcca acaggaacag gaatgggtgg acaatccatc tatggtgaaa gttttgaaga
    27361 tgaattttcg gatgaactgt ataaccttag aggagccctt tcaatggcaa acgcaggccc
    27421 aaatactaat ggtagccaat tcttcattgt tcaaaatagc aaaattcctt acgctaaaaa
    27481 agaattagaa cgtggtggtt ggcctactcc aattgcagct gcttatgctg aaaatggtgg
    27541 aactcctcac cttgatcggc gtcatactgt ttttggccaa ttagctgatg acgcttcttt
    27601 caaagttttg gacctgattg ctagcgttga aactggcgca caggataaac ctaaagaaga
    27661 cgttatcatt aaaacaattg aggtatttga ctaatgaaaa ttggcgacaa actgcatggc
    27721 accatcactg ggattaaacc atacggagcc tttgttgccc ttgacaatgg gacaacaggt
    27781 ctcattcata tttcagaaat aaaaacggga tttattgatg atattgatca attattggct
    27841 ataggcaacc aggttttagt acaagtaatt gatattgatg aatatagtaa aaaggcaagt
    27901 ttatctatgc ggaccttagc agaagaaaaa cagcattttt tccatcgtca tcgttattcc
    27961 aacagtcggc acaagattgg ctttaggcca cttgaagagc agttacctca gtggattgaa
    28021 gaaagcctgc agtttttaaa aaagaacact aaaaagagtc tggaacctta gtagttccaa
    28081 accctttttt atttcgtctt aattactggt acatcataga gttcagtcga taaatagcgt
    28141 tcgccattat ctggtaaaat agttaacaca tgtttgcctt ttcctaactg tttagcgact
    28201 tcaatagcgg cgtaaagagc agctccagaa gaaatcccaa ccaggaagcc ttccttagct
    28261 cctgttagtc gagcagtttc taaagcatct ttcgatttaa cacggataat ttggtcatag
    28321 gctttggtat ctaacgtgtt tgggataaat ccagctgata taccttggat tttatgtggt
    28381 ccaggctctt gaccagataa gacagcagat tcttcagctt caacagcata gatagcagtt
    28441 tcagggctag cttttttcaa gacatgtgaa acaccagaaa gtgttcctcc agtaccaaca
    28501 ccagatacga atgcatctaa agaaatctcc ttaaaagctt ccaaaatttc ttgagctgtt
    28561 gttttttcat ggatgcttgg attggcaggg ttattaaatt gcataggcat ccaagcacct
    28621 agttctattg ctaaagtttc agcttttgca atagcccctt tcataccttc tgctccaggt
    28681 gttaagacaa gctctgcacc ataagcctga atgatttgtc gtctttccaa gctcatcgtt
    28741 tcgggcataa caataatgac tcgataccct ttagcagcac ctacccatgc aagaccaata
    28801 cctgtattac cgctcgttgg ttcgataata acgtcaccag gacttatcag accttcagct
    28861 tcagcagctt caatcatcga taaagcaata cgatctttaa cagaagatcc tgggttaaaa
    28921 gcttctaatt ttacataaac gtcagcagct tcgtttggaa ttaaacggtt aagtttgata
    28981 ataggtgtct gacctactaa ttctgttata gttttgtaaa ttttagtcat agtttagcct
    29041 cttttcttga tacaaaataa atacgctgta tatttaagta taaggagaga tattattaaa
    29101 gtaaaataca gatttactat cactctgata ataaagccat atcacttttg ttgatgatta
    29161 atcacagggg aattcaataa ctttggatcc gattttctca cagcttatct gaccatgata
    29221 ataatttgtt aaagtatcaa tgagattttc cacacgttca gtatcacaat aaagtgttgt
    29281 ctttatcgtg tctgaaaact tagtttctgt ttcggttaaa gccaattgat ctagtaagtt
    29341 agagtatagt tgatattggg gataagaaag tgtgatttct agtcctatct gctgtttaac
    29401 ttcaatgatg ccaaatcgtt taatagctgt tgcggtcatg ttagagtatg ctctgattaa
    29461 cccacctgtt cctaatttaa taccaccaaa gtaacgcgtt accacaacta ctacatttgt
    29521 taaacactgc ttttctaaca cagaaaggat aggtattcca gcagttcctg aaggttcacc
    29581 atcatcactt gagcgcttga tctgactgtt gttaccgata atcatcgcaa agcaggaatg
    29641 attagctttg taatgttctt ttttgatagc attaacaaaa ttcttaccat cttcttcagt
    29701 gctcactcgt ttgatatgac aaatgaaacg agatttttta atactttctt cgaaaaaacc
    29761 actggatttg attgtcttaa aatgttccat aaaaaaattg tacaagaaaa gataaaaatt
    29821 agcaaaaaaa agcgaataat aaagtatgga gtctattgaa aatagttatg ggcggttgtt
    29881 gctagaaagc cagttaccag attcagcaag gcagcttgct caacctttaa aaagtgtagt
    29941 aatatcgaga ggaaaaatga tttgtcaacg ttgtcactat cagcttgatg aagaagcacg
    30001 attgccaagt ggagcctatt attgccgatt ttgtcttgtc tttggacgaa atcaatcaga
    30061 taaattgctc tatgctatcc cacctatgca ttttccaaaa ggtaattatc tggtttggag
    30121 cggtcaacta actgcttatc aagagatgat ttcccaacaa ttattaatca atatgcaaaa
    30181 tcaaaaaaca acattagttc atgctgtaac tggtgcagga aaaacagaaa tgatttatgc
    30241 tgcgattgag gcggtaatta acacaggtgg ctgggtttgc attgccagcc caagagtaga
    30301 tgtttgtgta gaggtggcta ctcgtttatc ccaagccttc tcctgcagca tctgtttaat
    30361 gcacgcagag tcttttcctt atcaaagagc tcctattata gtagccacaa cgcatcagct
    30421 gctaaaattt cacaaggctt ttgatctctt aattattgat gaagtagacg cattcccttt
    30481 tgtaaataat attcaacttc attatgctgc aagtcaggct ttaaaagaag gtggcgcaaa
    30541 gattttatta actgcaactt caactagaac tttagaaaga aaggtaaaca agggagaagt
    30601 agtcaagctg acattggcga gacgctttca taataggcca ttagttattc cgaaatttat
    30661 aagaagtttt aatctattta aaatgataca tcggcaaaaa cttcctccta aaattttaaa
    30721 atacttaaaa aaacaaagaa aaacaggcta tcccctttta atttttctac ccactattct
    30781 aatggcagaa tctgttacag caatcttaaa agagttattg cccgccgaac aaatagcttg
    30841 tgtttctagt caatcacaaa acaggaaaga agatatcaca gcttttcgtc aagggaaaaa
    30901 aacgatttta attacaacaa caattttaga aaggggtgtg acatttcccc aaattgatgt
    30961 ttttgttctt gggtctcatc atcgtgtcta tagttcccaa agtcttgttc aaattgctgg
    31021 acgagttgga agatctatag acagaccaga cggaacgtta tatttctttc atgaaggtat
    31081 cagtaaagca atgctactag caagaaaaga gattaaagaa atgaattata aagggtattc
    31141 gcatgatctg tctactatgt caacaaatta gtcaaacacc aataagtatt acagaaatca
    31201 tctttttaag gcgtatctct tcaccgattt gtcaacaatg tcaaaaaagc tttcaaaaga
    31261 taggaaaaag tgtttgtgcg acatgttgtg caaactcaga tataatagct tgtcgagatt
    31321 gtctaaaatg ggaaaacaaa ggatacaatg taaatcatag aagcttatat tgttataatg
    31381 ctgctatgaa agcatacttc agtcaatata agtttcaagg agactattta ttaagaaaag
    31441 tttttgcagt agaacttgcc gatgttatta ccaagtacta taaaggctat atcccagtcc
    31501 cggttcctgt aaatcccggt tgttttcgag aaagacaatt taatcaagtg agcgctattc
    31561 ttgaggcagc taatgttagc tacctttctc tttttgaaaa gctagataat actcaccaat
    31621 cttccagaac aaaaaaagag cgattattag tagaaaaatc ttatcgacta ctaaaagtat
    31681 caaacattcc tgataaaatc cttatagtag atgatattta tactactggt agtacaatta
    31741 tcgctcttag aaaacaattg gctaaagtag caaatagtga cattaaaagt ttgtcaattg
    31801 cacgttaaaa cttgcaaatt ttcatgaaag cagtataata gtattaaaga taaagtaagc
    31861 gcttcaagcg cgagaaagag gtatcctatg attaagttca gtattcgtgg agaaaatatc
    31921 gaagtgacag aagctattcg cgattatgta gaatcaaagc ttactaaaat cgaaaaatat
    31981 tttgctaaag accaagaaat agatgcacgt gttaatttaa aagtttatcg ggagagatct
    32041 tcaaaagttg aggtaacgat cccattagat tcagtaaccc ttcgtgctga agatgtttca
    32101 caggatatgt acggctctat tgatttagtt gttgataaga tcgaacgtca aattagaaaa
    32161 aataaaacca aaattgctaa aaaacatcgc gaaaaggttc caactggtca agtctttaca
    32221 actgagtttg aagctgaaga agtcgatgag ataccagaag tacaagttgt acgtactaaa
    32281 aatgtgacat taaaaccaat ggatgttgaa gaagcgcgtt tacagatgga actattggga
    32341 catgatttct ttatctacac tgattctgaa gatggtgcaa caaacatttt ataccgtcgc
    32401 gaagatggaa acctaggttt aatagaagct aaatagttca caattaaaac ctacagggat
    32461 gattatacgt attttaaaag tgggaaaaag ctattcatgt ttagaggtga catgatgaaa
    32521 atgagattaa gtgatagata cgacagtcat tatactaaca aaagtatcta ttacagttcc
    32581 tctttaagta aatcttacgt aaaattagtt tgaaaaaaag attagtccca attctgggct
    32641 agaaattctc aaaaaatatg aaaaagcgcg ttttcagaat ataaagcgcg tttttttctt
    32701 tttccattta acaataaaaa actcatgacg aacatggtat cataagagaa tttttact
//
LOCUS       DAUDWO010000023        32264 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.023, whole genome shotgun sequence.
ACCESSION   DAUDWO010000023 DAUDWO010000000
VERSION     DAUDWO010000023.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 32264)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32264)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32264
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.023"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            771..860
                     /locus_tag="VHC05_001035"
     CDS             771..860
                     /locus_tag="VHC05_001035"
                     /inference="COORDINATES: protein motif:HMM:NF024729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEQ5402353.1"
                     /translation="MIIDYCNNKRIKIKLKGLSPLQYKTKSFT"
     gene            complement(898..1821)
                     /locus_tag="VHC05_001036"
     CDS             complement(898..1821)
                     /locus_tag="VHC05_001036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402354.1"
                     /translation="MSEKLVEVKDLEISFGEGKKKFVAVKNANFFIKKGETFSLVGES
                     GSGKTTIGRAIIGLNDTSSGQILYDGKVINGRKSKSEANELIRKIQMIFQDPAASLNE
                     RATVDYIISEGLYNFNLFKTEEERKEKIKNMMAEVGLLSEHLTRYPHEFSGGQRQRIG
                     IARALVMNPEFVIADEPISALDVSVRAQVLNLLKRMQAEKGLTYLFIAHDLSVVRFIS
                     DRIAVIHKGVIVEVAETEELFNNPIHPYTQSLLSAVPIPDPILERQKELVVYHPDQHD
                     YTLDKPSMVEIKPNHFVWANQAEIEKYQKEL"
     gene            complement(1814..2884)
                     /locus_tag="VHC05_001037"
     CDS             complement(1814..2884)
                     /locus_tag="VHC05_001037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402355.1"
                     /translation="MTKENNVILTAKDVVVEFDVRDRVLTAIRNVSLELVEGEVLAFV
                     GESGSGKSVLTKTFTGMLESNGRIANGSIVYRGQELTDLKTNKEWAKIRGSKIATIFQ
                     DPMTSLSPIKTIGSQITEVIIKHQKVSHAKAKEMALDYMNKVGIPNAKKRFEDYPFEY
                     SGGMRQRIVIAIALACRPDILICDEPTTALDVTIQAQIVELLKSLQREYHFTIIFITH
                     DLGVVASIADKVAVMYAGEIVEFGTVEEIFYDPRHPYTWSLLSSLPQLADESGELYAI
                     PGTPPSLYSPIIGDAFALRSEYAMVLDFEKAPPAINVSETHWAKTWLLHPEAPKVQKP
                     EVIQDLHQKILRKMSQQEEGNV"
     gene            complement(2893..3819)
                     /locus_tag="VHC05_001038"
     CDS             complement(2893..3819)
                     /locus_tag="VHC05_001038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009569326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402356.1"
                     /translation="MESIDKSKFRFVERDSEASEVIDTPAYSYWKSVFRQFFSKKSTV
                     FMLVILVTVLMMSFIYPMFANYDFNDVSNINDFSKRYIWPNAEYWFGTDKNGQSLFDG
                     VWYGARNSILISVIATLINITIGVVLGAIWGVSKAFDKVMIEIYNIISNIPSMLIIIV
                     LTYSLGAGFWNLILAFCITGWIGVAYSIRVQILRYRDLEYNLASQTLGTPMYKIAVKN
                     LLPQLVSVIMTMLSQMLPVYVSSEAFLSFFGIGLPTTTPSLGRLIANYSSNLTTNAYL
                     FWIPLVTLILVSLPLYIVGQNLADASDPRSHR"
     gene            complement(3819..5321)
                     /locus_tag="VHC05_001039"
     CDS             complement(3819..5321)
                     /locus_tag="VHC05_001039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402357.1"
                     /translation="MKKYILNRIMRSLVSVVLVTALTYTIVYTLVPTSLIFKQDPNYN
                     KMTTTPDKKVAYENLTFQRMGYVNYFSSKELKDNASKVDSSVTTEATSANKAIYEKYI
                     DSLGNGWQLKRFPTSKQFYAIRNIPIYERVWNFFSNLVVIDHPWKIQDKDNPKLARYI
                     RLEKDKSVGWSLVGSGTKHKYLLYTNGKFPYLHQNFVTLNLGTSYPTYSNIPVLQVIS
                     QGQGRTALQDVTFPSGVTKKSSVDIYSRSYKNPKSLDDITKVNYGKGDSYTKTINNYV
                     DPSMIHNSFVIGFFGVMFSYIVGLPLGLFMARFKNTYFDRFSTATMTFMLALPSIAVI
                     YVVRFLGGMVGLPDSFPMLGASDPKSYILPALILGILNIPTTVIWFRRYLVDLQASDW
                     VRFARSKGLSESEIYRGHLFKNAMVPIVSGVPASIILAIGGATLTETVFAFPGMGKML
                     IDSIKSANNSMIVGLTFIFTVLSIVSLLLGDIVMTLVDPRIKLSTKKGGK"
     gene            complement(5386..7365)
                     /locus_tag="VHC05_001040"
     CDS             complement(5386..7365)
                     /locus_tag="VHC05_001040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEQ5402358.1"
                     /translation="MKKSKWLAAVSVAILSVSALAACGNKNASGGSEATKTYKYVFVN
                     DPKSLDYILTNGGGTTDVITQMVDGLLENDEYGNLVPSLAKDWKVSKDGLTYTYTLRD
                     GVSWYTADGEEYAPVTAEDFVTGLKHAVDDKSDALYVVEDSIKNLKAYQNGEVDFKEV
                     GVKALDDKTVQYTLNKPESYWNSKTTYSVLFPVNAKFLKSKGKDFGTTDPSSILVNGA
                     YFLSAFTSKSSMEFHKNENYWDAKNVGIESVKLTYSDGSDPGSFYKNFDKGEFSVARL
                     YPNDPTYKSAKKNYADNITYGMLTGDIRHLTWNLNRTSFKNTKKDPAQQDAGKKALNN
                     KDFRQAIQFAFDRASFQAQTAGQDAKTKALRNMLVPPTFVTVGESDFGSEVEKEMAKL
                     GDEWKDVNLADAQDGFYNPEKAKVEFAKAKEALTAEGVTFPVQLDYPVDQANAATVQE
                     AQSFKQSVEASLGKENVIVNVLETETSTHEAQGFYAETPEQQDYDIISSWWGPDYQDP
                     RTYLDIMSPVGGGSVIQKLGIKAGQNKDVVAAAGLDTYQTLLDEAAAITDDNDARYKA
                     YAKAQAYLTDSAVDIPVVALGGTPRVTKAVPFSGAFAWAGAKGPASVYYYKGMKLQDK
                     PVTAKQFEKAKEKWMKAKAKSNAKYAEKLADHVEK"
     gene            7696..8928
                     /locus_tag="VHC05_001041"
     CDS             7696..8928
                     /locus_tag="VHC05_001041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HEQ5402359.1"
                     /translation="MIKRLISLVVIALFFAASTVSGEEYSVTAKHAIAVDLESGKVLY
                     EKDAKEVVPVASVSKLLTTYLVYKEVSKGKLNWDSPVTISNYPYELTTNYTISNVPLD
                     KRKYTVKELLSALVVNNANSPAIALAEKIGGTEPKFVDKMKKQLRQWGISDAKVVNST
                     GLTNHFLGANTYPNTEPDDENCFCATDLAIIARHLLLEFPEVLKLSSKSSTIFAGQTI
                     YSYNYMLKGMPCYREGVDGLFVGYSKKAGASFVATSVENQMRVITVVLNADQSHEDDL
                     AIFKTTNQLLQYLLINFQKVQLIENNKPVKTLSVLDSSEKTVKLVAQNSLFFIKPIHT
                     KTKNTVHITKKSSTMIAPLSKGQVLGRATLQDKHLIGQGYLDTPPSINLILQKNISKS
                     FFLKVWWNRFVRYVNTSL"
     gene            9096..10277
                     /locus_tag="VHC05_001042"
     CDS             9096..10277
                     /locus_tag="VHC05_001042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HEQ5402360.1"
                     /translation="MTKRIILTIFTFICFSMMPLVHADDVMDITRQAGYTVSEVNRPK
                     SSIVVDANSSDILWQDNIDIPRDPASMSKMFTLYILFEELAKGKITMDTTITATPTDQ
                     AIANIYEISNNNIVAGVAYPIRDLITMTAVPSSNAATVMIANYLSNNDASAFIDRINA
                     TAKQLGMTNTHFSNASGAAAQAFQGYYNPTKYDLSASNITTARDLSKLLYAFLKKYPE
                     IISFTNKSVVHTMVGTPYEEEFHTYNHSLPDNQFGMKGVDGLKTGSSPSAAFNAMITA
                     KRGKTRLITIVMGVGDWSDQNGEFYRHPFVNALTEKGFKDSKTLSKKARQKLEKLVPQ
                     TKKETSPKQQHFKATKKQSYLERVEDFMNYNHTFLLICLAIFIITILLLSLVVFAMGR
                     Q"
     gene            complement(10429..11847)
                     /gene="sufB"
                     /locus_tag="VHC05_001043"
     CDS             complement(10429..11847)
                     /gene="sufB"
                     /locus_tag="VHC05_001043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017769002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufB"
                     /protein_id="HEQ5402361.1"
                     /translation="MSDINEKVEPKPIDLGDYQFGFHDDVEPIYSTGKGLSEAVVREL
                     SAAKNEPEWMLEFRLKSLETFNKMPMQTWGADLSDINFDDIIYYQKASDKPARSWDDV
                     PEKIKETFDRIGIPEAERAYLAGASAQYESEVVYHNMKGEFEKLGIIFTDTDSALKEY
                     PDLFKQYFAKLVPPTDNKLAALNSAVWSGGTFIYVPKGVKVDIPLQTYFRINNENTGQ
                     FERTLIIVDEGASVHYVEGCTAPTYSSNSLHAAIVEIFALDGAYMRYTTIQNWSDNVY
                     NLVTKRARALTDATVEWIDGNLGAKTTMKYPSVYLDGPGARGTMLSIAFANAGQHQDT
                     GAKMIHNAPHTSSSIVSKSIAKSGGKVDYRGQVTFNKQSKKSVSHIECDTILMDDISK
                     SDTIPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLSESEATEMIVMGFVEPFTKE
                     LPMEYAVELNRLISYEMEGSVG"
     gene            complement(11840..12319)
                     /locus_tag="VHC05_001044"
     CDS             complement(11840..12319)
                     /locus_tag="VHC05_001044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SUF system NifU family Fe-S cluster assembly
                     protein"
                     /protein_id="HEQ5402362.1"
                     /translation="MALSKLNHLYMAVVADHSKRPHHHGQLDGVEAVRLNNPTCGDVI
                     SLTVKFDEDKIEDIAFAGNGCTISTASSSMMTDAVIGKSKEEALALADIFSEMVQGQE
                     NPAQKELGEAELLAGVAKFPQRIKCSTLAWNALKEAIKRSANAQHLTDQNVKEGKNV"
     gene            complement(12306..13532)
                     /locus_tag="VHC05_001045"
     CDS             complement(12306..13532)
                     /locus_tag="VHC05_001045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEQ5402363.1"
                     /translation="MLDAKDIKQDFQILNQQVNDEPLVYLDNAATTQKPALVLEALQS
                     YYQEDNANVHRGVHTLAERATHKYEASRQHVADFIHAKSSKEVLFTRGTTTSLNWVAR
                     FAEQVLTPEDEVLISIMEHHANIIPWQQACQKTGARLVYVYLKDGQLDMDDLTNKLTT
                     KTRFVSLVHVSSVLGCINPIKEIAKLAHAKGAYLVVDGAQSVPHLAIDVQDLDCDFFA
                     FSAHKMLGPTGLGVLYGKEELLNQVEPLEFGGEMIDFVYEQEATWKELPWKFEAGTPH
                     IAGAIGLSAAISYLQRLGMADIHAHEAELIAYVLPKLEAIEGLTIYGPSQSSARSGLI
                     SFNLDDLHPHDLATALDYEGVAVRAGHHCAQPLLSYLGVPATVRASFYIYNTKADCDR
                     LVEAILKAKEFFNGTL"
     gene            complement(13563..14825)
                     /gene="sufD"
                     /locus_tag="VHC05_001046"
     CDS             complement(13563..14825)
                     /gene="sufD"
                     /locus_tag="VHC05_001046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufD"
                     /protein_id="HEQ5402364.1"
                     /translation="MTKEKLVAFSQAHAEPAWLQERRLAALEAIPNLELPTIERVKFH
                     RWNLGDGTLTENESLASVPDFIAIGDNPKLVQVGTQTVLEQLPMALIDKGVVFSDFYT
                     ALEEIPEVIEAHFGQALAFDEDKLAAYHTAYFNSAAVLYVPDHLEITTPIEAIFLQDS
                     DSDVPFNKHVLVIAGKESKFTYLERFESIGNATQKTSANISVEVIAQAGSQIKFSAID
                     RLGPSVTTYISRRGRLEKDANIDWTLAVMNEGNVIADFDSDLIGQGSQADLKVVAASS
                     GRQVQGIDTRVTNYGQRTVGHILQHGVILERGTLTFNGIGHILKGAKGADAQQESRVL
                     MLSDQARADANPILLIDENEVTAGHAASIGQVDPEDMYYLMSRGLDQETAERLVIRGF
                     LGAVIAEIPIPSVRQEIIKVLDEKLLNR"
     gene            complement(14920..15690)
                     /gene="sufC"
                     /locus_tag="VHC05_001047"
     CDS             complement(14920..15690)
                     /gene="sufC"
                     /locus_tag="VHC05_001047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly ATPase SufC"
                     /protein_id="HEQ5402365.1"
                     /translation="MSILEINNLYVSIEGKEILKGVNLTLKTGEVAAIMGPNGTGKST
                     LSAVIMGNPNYEVTQGQILLDGVNILDLEVDERARLGLFLAMQYPSEIPGITNAEFMR
                     AAMNAGKADEDKISVRDFITKLDEKMALLGMKEEMAERYLNEGFSGGEKKRNEILQLL
                     MLEPKFALLDEIDSGLDIDALKVVSKGVNEMRGKDFGAMIITHYQRLLNYITPDLVHV
                     MMDGRIVLSGDAALATRLEKEGYAGIAQDLGIEYKEES"
     gene            complement(15812..16981)
                     /locus_tag="VHC05_001048"
     CDS             complement(15812..16981)
                     /locus_tag="VHC05_001048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl/decaprenyl-phosphate
                     alpha-N-acetylglucosaminyl 1-phosphate transferase"
                     /protein_id="HEQ5402366.1"
                     /translation="MFSFTIDYVLVLIGALLMSLFLTPLVRFLAFRVGAVDNPNARRV
                     NKVPMPTSGGLAIFMSFLVASLGLIPIASKGAMFFGQTYFSYILPVVIGATVITLTGF
                     LDDLYELSPKLKMFGILIGAVIVWAFTDFKFDSFKIPFGGPLLVFGPFLTLFLTVLWI
                     VSITNAINLIDGLDGLVSGVSIISLVTMAIVSYFFLPQKDFFLTLTILVLIAAIAGFF
                     PYNYHPAMIYLGDTGALFIGFMIGVLSLQGLKNSTAVAVVTPVIILGVPIMDTIVAII
                     RRSLSGQKFYEPDKMHLHHRLLSMGFTHRGAVLVVYGITMLFSLISLLLNVSSRIGGV
                     LLILGLLFGLEVFIEGLEIWGEKRTPLFNLLKFIGNSDYRQAMLLKWKEKKDLKH"
     gene            complement(16988..17749)
                     /gene="mecA"
                     /locus_tag="VHC05_001049"
     CDS             complement(16988..17749)
                     /gene="mecA"
                     /locus_tag="VHC05_001049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adaptor protein MecA"
                     /protein_id="HEQ5402367.1"
                     /translation="MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSV
                     MDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEINKDINLEDLAEFGDMSQMTPED
                     FFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHDSEPLDYIH
                     YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLI
                     EHANPGSKTRAYLQEHGLQLMLDGAVEQLQKIELG"
     gene            complement(17895..18734)
                     /locus_tag="VHC05_001050"
     CDS             complement(17895..18734)
                     /locus_tag="VHC05_001050"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HEQ5402368.1"
                     /translation="MLIIELLKAIFFGIIEGITEWLPVSSTGHLILVQEFIRLNQDKA
                     FIEMFNIVIQLGAIIAVMLIYFERLNPFQPGKTAREVQLTWQLWLKVVIACIPSILIA
                     VPLDNWFEAHFYFMVPIAIALIVYGIAFIWIEKQNAQQEPAVTDLARMSYKTAFFIGC
                     FQVLSIVPGTSRSGATILGAIILGTSRTVAADFTFFLAIPTMFGYSGLKAVKFFLDGH
                     HLDFAQVLILLVASLTAFVVSLLAIRFLTDYVKKHDFTIFGKYRIVLGSLLLIYSFFK
                     FVF"
     gene            complement(18800..20725)
                     /locus_tag="VHC05_001051"
                     /pseudo
     CDS             complement(18800..20725)
                     /locus_tag="VHC05_001051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407295.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2207 domain-containing protein"
     gene            20923..22491
                     /locus_tag="VHC05_001052"
     CDS             20923..22491
                     /locus_tag="VHC05_001052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HEQ5402369.1"
                     /translation="MKKLILSCLVALALLFGGMSRAQANQYLRVGMEAAYAPFNWTQD
                     DASNGAVPIEGTSQYANGYDVQVAKKVAKAMNKELLVVKTSWTGLIPALTSGKIDMIA
                     AGMSSTKERRNEISFSNSYYTSQPVLVVTANGKYADATSLKDFSGAKVTAQQGVWHVN
                     LLTQLKGAKLQTPMGDFSQMRQALTSGVIDAYISERPEAMTAEAADSRLKMITLKKGF
                     AVAESDAAIAVGMKKNDDRMATVNQVLEGFSQTDRMALMDDMVTKQPVEKKAEDAKAS
                     FLGQMWAILKGNWKQFLRGTGMTLLISMVGTITGLFIGLLIGIFRTAPKAKHKVAALG
                     QKLFGWLLTIYIEIFRGTPMIVQSMVIYYGTAQAFGISIDRTLAAIFIVSINTGAYMS
                     EIVRGGIFAVDKGQFEAATALGFTHGQTMRKIVLPQVVRNILPATGNEFVINIKDTSV
                     LNVISVVELYFSGNTVATQTYQYFQTFTIIAIIYFVLTFTVTRILRHIERRFDADTYT
                     TGANQMQIAEVSNV"
     gene            22484..23224
                     /locus_tag="VHC05_001053"
     CDS             22484..23224
                     /locus_tag="VHC05_001053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402370.1"
                     /translation="MSNSIIEIKNLKKSYGSNEVLKDISLSVNKGEVISIIGSSGSGK
                     STLLRSINLLEEPSAGQILFHGEDVLAEHYNLTHYREKLGMVFQSFNLFENLNVLENA
                     IVAQTTVLKRDRPQAEQIAKENLNAVGMTEQYWQAKPKQLSGGQKQRVAIARALSVNP
                     EAMLFDEPTSALDPEMVGEVLKTMQDLAKSGLTMIIVTHEMEFARDVSDRIIFMDKGL
                     IAEEGSPQQIFENPTQDRTKEFLQRFLK"
     gene            23366..23482
                     /locus_tag="VHC05_001054"
     CDS             23366..23482
                     /locus_tag="VHC05_001054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000818732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative metal homeostasis protein"
                     /protein_id="HEQ5402371.1"
                     /translation="MAEKTDLSSAYRRLKSPNIKTRKRALKIIHEYKRYGKK"
     gene            complement(23708..24718)
                     /gene="gap"
                     /locus_tag="VHC05_001055"
     CDS             complement(23708..24718)
                     /gene="gap"
                     /locus_tag="VHC05_001055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008090210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HEQ5402372.1"
                     /translation="MVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHL
                     LKYDTTQGRFDGTVEVKEGGFEVNGNFIKVSAERDPENIDWATDGVEIVLEATGFFAK
                     KEAAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPM
                     AKALHDAFGIQKGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAI
                     GLVIPELNGKLDGAAQRVPVPTGSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTED
                     PIVSSDIVGVSYGSLFDATQTKVMEVDGSQLVKVVSWYDNEMSYTAQLVRTLEYFAKI
                     AK"
     gene            complement(25059..27137)
                     /gene="fusA"
                     /locus_tag="VHC05_001056"
     CDS             complement(25059..27137)
                     /gene="fusA"
                     /locus_tag="VHC05_001056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000090325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HEQ5402373.1"
                     /translation="MAREFSLAKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETH
                     EGASQMDWMEQEQERGITITSAATTAQWDGHRVNIIDTPGHVDFTIEVQRSLRVLDGA
                     VTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVQTLHDRLQANAH
                     PIQLPIGAEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPEEYLEQAQEYREKLIEAV
                     AETDEDLMMKYLEGEEITNDELIAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVIA
                     YLPSPLDIPAIKGVNPDTDAEEERPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVL
                     NSGSYVMNTSKGKRERIGRILQMHANSRQEIETVYAGDIAAAVGLKDTTTGDSLTDEK
                     AKVILESIEVPEPVIQLMVEPKSKADQDKMGVALQKLAEEDPTFRVETNVETGETVIA
                     GMGELHLDVLVDRMKREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDV
                     WIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLIESMANGVLAGYPMVDVKAKLY
                     DGSYHDVDSSETAFKIAASLALKEAAKSAQPAILEPMMLVTITAPEDNLGDVMGHVTA
                     RRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSATQGRGTFMMVFDHYEDVPKSVQ
                     EEIIKKNKGE"
     gene            complement(27621..28091)
                     /gene="rpsG"
                     /locus_tag="VHC05_001057"
     CDS             complement(27621..28091)
                     /gene="rpsG"
                     /locus_tag="VHC05_001057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S7"
                     /protein_id="HEQ5402374.1"
                     /translation="MSRKNQAPKREVLPDPLYNSKIVTRLINRVMLDGKRGTAATIVY
                     DAFSAIKEATGNDALEVFETAMDNIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLR
                     WLVNASRARGEHTMKDRLAKEIMDAANNTGASVKKREDTHKMAEANRAFAHFRW"
     gene            complement(28112..28525)
                     /gene="rpsL"
                     /locus_tag="VHC05_001058"
     CDS             complement(28112..28525)
                     /gene="rpsL"
                     /locus_tag="VHC05_001058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12"
                     /protein_id="HEQ5402375.1"
                     /translation="MPTINQLVRKPRKSKIEKSDSPALNIGYNSHKKVQTKMAAPQKR
                     GVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLIRGGRVKD
                     LPGVRYHIVRGALDTAGVADRKQGRSKYGAKRPKG"
     gene            complement(28733..31354)
                     /locus_tag="VHC05_001059"
     CDS             complement(28733..31354)
                     /locus_tag="VHC05_001059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SEC10/PgrA surface exclusion domain-containing
                     protein"
                     /protein_id="HEQ5402376.1"
                     /translation="MDLEQTKPNQVKQKIALTSTIALLSASVGVSHQVKADDRASGET
                     KASNTHDDSLPKPETIQEAKATIDAVEKTLSQQKAELTKLATALTKTTAEINHLKEQQ
                     DNEQKALTSAQEIYTNTLASSEETLLAQGAEHQRELTATETELHNAQADQHSKETALS
                     EQKASISAETTRAQDLVEQVKTSEQNIAKLNAMISNPDAITKAAQTANDNTKALSSEL
                     EKAKADLENQKAKVKKQLTEELAAQKAALAEKEAELSRLKSSAPSTQDSIVGNNTMKA
                     PQGYPLEELKKLEASGYIGSASYNNYYKEHADQIIAKASPGNQLNQYQDIPADRNRFV
                     DPDNLTPEVQNELAQFAAHMINSVRRQLGLPPVTVTAGSQEFARLLSTSYKKTHGNTR
                     PSFVYGQPGVSGHYGVGPHDKTIIEDSAGASGLIRNDDNMYENIGAFNDVHTVNGIKR
                     GIYDSIKYMLFTDHLHGNTYGHAINFLRVDKRNPNAPVYLGFSTSNVGSLNEHFVMFP
                     ESNIANHQRFNKTPIKAVGSTKDYAQRVGTVSDTIAAIKGKVSSLENRLSAIHQEADI
                     MAAQAKVSQLQGKLASTLKQSDSLNLQVRQLNDTKGSLRTELLAAKAKQAQLEATRDQ
                     SLAKLASLKAALHQTEALAEQAAARVTALVAKKAHLQYLRDFKLNPNRLQVIRERIDN
                     TKQDLAKTTSSLLNAQETLAALQAKQSGLEATIATTEHQLTLLKTLANEKEYRHLDED
                     IATVPDLQVAPPLTGVKPLSYSKIDTTPLVQEMVKETKQLLEASARLAAENTSLVAEA
                     LVGQTSEMVASNAIVSKITSSITQPSSKTSYGSGSSTTSNLISDVDESTQRALKAGVV
                     MLAAVGLTGFRFRKESK"
     gene            complement(31345..32184)
                     /gene="purR"
                     /locus_tag="VHC05_001060"
     CDS             complement(31345..32184)
                     /gene="purR"
                     /locus_tag="VHC05_001060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pur operon repressor"
                     /protein_id="HEQ5402377.1"
                     /translation="MKLRRSERMVVISNYLINNPYKLTSLNTFATKYEAAKSSISEDI
                     AIIKKAFEEGNIGDIDTLTGASGGVIFTPSISETEARTIVEDLCQRLSESDRILPGGY
                     IYLSDLLSTPKILQNIGRIIANAFKGEKIDAVMTVATKGVPLANAVANILSVPFVIVR
                     RDLKITEGSTVSVNYASASSDRIEKMFLSKRSLKPNSRVLIVDDFLKGGGTITGMISL
                     LTEFDSTLVGVAVFAENAQSEREQMTFKSLLKVSEIDVKNNNVVVEVGNIFDKWKKER
                     EWT"
BASE COUNT         9677 a         6661 c         5920 g        10006 t
ORIGIN      
        1 tttggttcgt cttattcagt tctcaaaggt cttaacgtct cctaagagac aacttcttta
       61 ttctatcagg tttctcatag cctgtcaact actttttcat cttttttcaa taagtgtgtt
      121 acaggaacct ctctgacagc tttattagta tacgatatct ttactgtcat tgtcaactct
      181 ttttttactt tttttgtact tttttatttg cccgcgttgt aaaatgaagt gcaacaaaaa
      241 agaggaaaag ccttgaacta caccccaaac gttagacaaa aaaatctaac gttcggggta
      301 ttttttatga aattaagtga tgaaggtacg aaatagacat cgttaagaaa gaaaaaaata
      361 cctactatcc accagagata aagcaggaaa taatggataa cgttttgata gaaggcccgc
      421 cacaatacca agtatcactt gtttatggct tgttacatgc aggaactctc ccaagttgaa
      481 tagcacaata taagaaaaac agttatactg ttgagaaaac aagagcaaga ccatcacaaa
      541 caggacgtaa accaaaagaa acctgaagaa atgactaaat tagagcggct tcaagaagaa
      601 aatgaatatc tcagaactga ggttgcttac ttaaaaaaac cgaggaactc cgtttgaaag
      661 aagcatctct gcaaagaagg agacaaaaaa accattataa aaaatggaca aagacgagct
      721 ctgattagat tttcttttaa gaacggctgt attgactcgt tctacctact attatcatcg
      781 attattgcaa caataaacgt atcaaaataa aactaaaagg acttagtcct ctacaataca
      841 aaactaaatc ctttacttaa aatagagtag ccaacttttg gggtcagtgc atctctttta
      901 caattctttt tgatattttt caatttctgc ttggtttgcc caaacaaagt gatttggttt
      961 gatttcaacc attgatggct tatctaatgt ataatcatgc tggtctggat gatagacaac
     1021 aagttctttt tgacgctcta aaattggatc tgggataggc acggctgata acaaagattg
     1081 ggtgtaggga tgaattgggt tattaaacag ttcttctgtt tctgcaactt ctacaataac
     1141 ccctttatgg ataaccgcaa tacgatctga aataaagcga acgactgaaa gatcatgggc
     1201 aatgaagaga taagtcaaac ctttttcggc ttgcatccgt ttgagaaggt ttaaaacctg
     1261 tgcgcgaacg gaaacgtcca aagctgaaat cggttcatca gcaataacga attcagggtt
     1321 cattactagg gctctagcga taccgatccg ctgacgttga cctcctgaaa attcatgtgg
     1381 gtagcgcgtc aaatgctctg atagcaaacc aacttcggcc atcatgttct taattttttc
     1441 tttacgttct tcctctgttt taaacagatt aaagttataa agaccttctg aaatgatgta
     1501 gtcaacggtt gctcgttcat tcaaactagc agcgggatct tggaaaatca tttgaatttt
     1561 acgaatgagc tcattggctt ctgattttga ttttctgcca ttaattactt tcccatcgta
     1621 taaaatttga cctgaactag tatcgttcaa accaataata gcacgaccaa ttgttgtttt
     1681 accactccca gattctccaa ctaaagaaaa ggtttctcct tttttaataa agaaattagc
     1741 atttttaact gcaacaaatt ttttctttcc ttctccgaag gaaatttcta ggtcttttac
     1801 ttcgactaat ttctcagaca tttccttcct cctgttgtga cattttcctt aagatttttt
     1861 gatgcaaatc ttgaatgact tctggttttt gaacttttgg agcctctggg tgtaaaagcc
     1921 atgttttggc ccaatgagtc tcagatacgt taatcgccgg aggtgctttt tcaaagtcta
     1981 aaaccatagc atattctgag cgaagtgcaa aggcatctcc gataattggt gaataaagtg
     2041 atggaggcgt tcctggaata gcgtaaagtt caccagattc atctgccaac tgcggtaagc
     2101 tagacagcaa actccatgta taggggtgtc ttggatcata gaaaatctct tcgactgttc
     2161 caaattcaac aatttctcct gcatacatga cagccacttt atctgcaatg cttgccacaa
     2221 cacctaaatc gtgcgtaata aagataatgg tgaaatgata ttctcgttga agcgacttca
     2281 ataactcaac gatttgagct tgaatagtca catcaagggc tgttgttggc tcatcacaga
     2341 taagaatatc tgggcgacaa gctaaagcaa tagcgataac aatacgttga cgcattcctc
     2401 ctgaatactc aaatgggtaa tcttcaaagc gttttttggc atttgggata cccactttat
     2461 tcatgtaatc aagggccatt tctttagctt tggcatgact tactttttgg tgcttaataa
     2521 tcacttctgt gatttggcta ccaatagttt taatgggact aagactggtc attgggtctt
     2581 ggaaaatcgt tgcgattttt gagccgcgaa tctttgccca ctctttattt gtttttaaat
     2641 ctgtcaattc ttgcccacga tagacaattg aaccattagc aatgcgtcca ttagactcca
     2701 acatccctgt aaaggtcttt gttaaaacag atttacctga gcctgattcc cctacaaaag
     2761 caaggacttc tccttcaaca agttccagtg agacgttacg gatagctgtt aaaacacgat
     2821 cacgcacatc aaattctacc accacatctt tggcagttaa gattacatta ttttcttttg
     2881 tcattttaac tcctatctat gtgaacgtgg gtcactggca tcagccaagt tttgtccgac
     2941 aatgtatagt ggtaacgata ctaaaatcaa tgttactaag ggaatccaaa agaggtaggc
     3001 atttgttgtt aagttgcttg aataattagc aatcaaacgt cctaaacttg gagtggtggt
     3061 tggtaaacca atcccaaaga aggataagaa ggcctcagaa gatacataaa ctggtagcat
     3121 ttgtgacaac atagtcatga taactgaaac caattgaggc agcaggttct taacagcaat
     3181 cttgtacatt ggtgttccca aagtttgact agcaaggttg tattctaaat cacggtaacg
     3241 caagatttga acacggatgg agtaggcgac accaatccat ccagtgatac agaaagctag
     3301 aatcaaattc caaaatcctg cacctaatga ataggtcaaa acaatgataa taagcataga
     3361 agggatattt gagataatgt tataaatttc aatcataact ttatcaaatg ctttagaaac
     3421 tccccatatg gctcctaaca ctaccccaat ggtgatatta attagtgtcg ctataactga
     3481 gattaaaata gaattacgtg ccccatacca aacaccatca aacagagatt gcccattttt
     3541 gtcggttcca aaccagtact ctgcatttgg ccaaatataa cgctttgaaa agtcattgat
     3601 attactaacg tcattaaagt cgtagttggc aaacattgga taaataaagc tcatcatcaa
     3661 gactgtcact aaaatcacga gcataaagac tgtagatttt ttagaaaaaa actgacgaaa
     3721 cactgatttc cagtaagaat aagcaggggt atcaatcact tcggaggctt cactatcgcg
     3781 ctcaacaaat cgaaatttag atttatcaat cgattccatt acttacctcc tttttttgtt
     3841 gacaatttaa tacgtggatc gacaagggtc atgacaatat ctcctagtaa aagtgaaaca
     3901 attgacaaga cagtgaagat aaaggttaat ccaacaatca tagaattgtt agcagattta
     3961 atagaatcaa ttaacatttt acccataccc gggaaggcaa agacagtctc tgttaatgtt
     4021 gcaccaccaa tagcaaggat aatacttgca ggaacccctg acacaattgg gaccatggca
     4081 tttttgaaga gatgccctct gtaaatttca gattctgata atccttttga acgcgcaaaa
     4141 cgtacccaat cgctggcctg aaggtcaaca agatagcgac ggaaccagat aaccgtagtt
     4201 ggaatattta aaattcctaa aataagggct ggtaaaatat aagatttagg atcagatgcc
     4261 cccagcattg ggaaactatc tggtaaacca accatgccac ctaggaagcg aacaacatag
     4321 ataacagcaa tacttggtaa agcaagcatg aaggtcatgg tcgctgttga gaaacggtca
     4381 aaataggtat ttttaaaccg agccataaat aaaccaagag gcaaaccaac gatataggaa
     4441 aacataacac caaaaaaacc aattacaaaa gaattgtgaa tcattgatgg gtcgacataa
     4501 ttattgatgg ttttagtgta ggaatctccc ttaccatagt ttaccttggt gatatcatcc
     4561 aatgattttg gatttttgta gctacggcta tagatatcca ctgacgattt cttagtgaca
     4621 cctgatggga aggtcacatc ttgaagagct gttcgtcctt gcccttgtga aataacctga
     4681 agaacaggaa tattgctgta tgttgggtaa gaggttccta agtttagggt aacaaaattt
     4741 tggtgaagat aaggaaattt tccgttagta tagaggagat atttatgttt tgtccccgaa
     4801 ccaacaagtg accagccaac tgatttatct ttttctagac gaatatacct agctaatttt
     4861 ggattatctt tatcctgaat cttccaaggg tgatcaataa caactagatt tgagaaaaag
     4921 ttccaaacac gttcgtaaat aggaatattg cgaattgcat aaaactgttt gctagtgggg
     4981 aagcgtttta gctgccagcc attgccaaga gaatcaatat acttctcata gatagctttg
     5041 ttagcactag ttgcttctgt cgttacacta ctatctactt tagaagcatt atcttttaat
     5101 tctttgcttg aaaaataatt gacataaccc atacgttgaa aagttagatt ttcatacgct
     5161 acttttttat ctggtgttgt tgtcatttta ttataattag ggtcttgttt aaagataagg
     5221 ctggtaggta ctagagtata tacgatggtg tatgttaaag ccgttaccaa aactaccgac
     5281 actaacgatc gcatgatacg gtttaaaatg tattttttca tagttatcct caatagttca
     5341 aaagaactct ctcacataaa cgagaaagtt cttttgaaca tcgttttatt tttcaacgtg
     5401 atcagctaac ttctcagcat attttgcatt tgacttagcc tttgctttca tccatttttc
     5461 ttttgctttt tcgaattgtt ttgctgtgac aggtttgtct tgaagtttca ttcctttata
     5521 ataatataca gaagcaggac ctttagcacc tgcccaggca aaggcaccgc taaatggaac
     5581 ggctttagta actcgaggag tgccacccaa tgccacaact ggaatatcta cggcactatc
     5641 tgtaaggtag gcttgtgctt ttgcgtaagc tttatagcgc gcatcgttgt cgtctgtaat
     5701 tgctgctgct tcatcaagaa gagtttggta agtatcaagg cctgcagctg ccacaacatc
     5761 cttattttga cctgctttga ttccaagttt ttggataaca gatccaccac ctactggact
     5821 catgatgtca aggtaggtcc gtggatcttg gtagtctggt ccccaccatg atgaaatgat
     5881 atcgtagtct tgttgttctg gggtctcagc atagaagcct tgggcttcgt gagttgatgt
     5941 ttctgtttca agaacattga caatgacatt ttctttacca agagatgctt caacagattg
     6001 tttgaaagac tgggcttcct gaacagttgc tgcgtttgcc tggtcaacag ggtaatctaa
     6061 ttgaactggg aaggttacac cttcagctgt caaagcttct ttggcttttg caaattcaac
     6121 ttttgctttt tctggattat agaaaccatc ttgagcatca gctaagttaa cgtctttcca
     6181 ttcatcacca agttttgcca tttccttttc aacttctgaa ccaaaatcac tttctccaac
     6241 ggttacaaaa gttggtggca caagcatgtt acgtaaggct tttgttttgg catcttgacc
     6301 tgcagtttgt gcttggaatg acgctcggtc aaaagcaaat tgaatagctt gacgaaaatc
     6361 cttgttgtta agagctttct taccggcatc ttgttgtgca gggtctttct tagtgttttt
     6421 gaaagaagta cggttcaaat tccatgttaa atgacggata tctccagtca acattccgta
     6481 agtaatgtta tcagcatagt ttttcttagc tgatttgtag gtagggtcat ttgggtaaag
     6541 tcgtgcaacg ctgaactcac ccttgtcaaa gttcttgtag aacgaacctg ggtctgaacc
     6601 atctgagtaa gtcaatttaa cagattctat cccaacattc ttagcatccc agtagttttc
     6661 atttttatgg aattccatag atgattttga ggtgaaggcg ctcaagaagt aagcaccatt
     6721 aacaaggatt gatgatggat cggttgtacc aaaatcttta ccttttgact tcaaaaattt
     6781 cgcattaact gggaaaagca cactataagt tgtttttgaa ttccagtagc tttcaggctt
     6841 gttcaaagta tactgaacag ttttatcgtc aagggctttg acaccaactt ctttaaaatc
     6901 tacttcacca ttttggtaag cctttaagtt ttttattgaa tcttcaacaa cgtaaagagc
     6961 atctgattta tcgtcaaccg cgtgcttcaa accagtcaca aaatcttctg ctgttactgg
     7021 ggcatattct tcaccatcag ccgtatacca agagacacca tcgcgaagag tataagtata
     7081 agtcagaccg tcttttgaaa ccttccaatc tttagcaagt gatggtacta aattaccata
     7141 ctcatcgttt tccaaaagac catcaaccat ttgtgttatc acatcagtcg ttccaccgcc
     7201 attagtcaaa atataatcca atgattttgg atcgttaaca aaaacgtact tgtaggtttt
     7261 tgtagcttct gagccacctg aagcattttt attaccacaa gctgccaaag cggatactga
     7321 caagatcgca acacttacag ctgccaacca tttacttttc ttcataaaag tcacccctaa
     7381 actttatttt tcattttttg gcaattgcta aatgaaattg gttaattgaa gacattatat
     7441 cataaaactt tcttaaagaa aataatgaaa tgaaaaatta tctgaatatt tcgtagaatt
     7501 ttctttattt tatacattta tctatatgaa agcgttacac tcctttttta atgaggtttc
     7561 aattagttta ataaagattg tcattctctc atggtagcgt tttattacat cactactctt
     7621 gtgaggtaag tcattacctt agacaaaaat atggtataat taaaaaaata atacttgagt
     7681 aaggataatc tataaatgat caaacgatta atttccctag tggtcatcgc cttatttttt
     7741 gcagcaagca ctgttagcgg tgaagagtat tcggtaactg ctaagcatgc gattgccgtt
     7801 gaccttgaaa gtggcaaagt tttatacgaa aaagatgcta aagaagttgt cccagtcgcc
     7861 tcagtcagta agctcttgac aacctatctg gtttacaaag aagtttctaa gggcaagcta
     7921 aattgggata gtcctgtaac tatttctaac tacccttatg aactcactac aaactatact
     7981 attagtaacg ttcctcttga taagagaaaa tataccgtta aagaactttt aagtgcgtta
     8041 gttgttaata acgccaatag ccccgctatt gctttagctg aaaaaatagg cggaaccgaa
     8101 cccaaatttg ttgacaaaat gaaaaaacaa ttaagacaat ggggtatttc cgatgcaaag
     8161 gtcgtcaatt caactggctt aactaaccat tttttaggag ctaatactta tcctaataca
     8221 gaaccagatg atgaaaattg tttttgcgcc actgatttag ctattattgc caggcatctc
     8281 ttattagaat ttccagaagt actgaaatta tctagcaaat cctccactat ttttgctgga
     8341 caaaccattt acagttataa ttacatgctt aaaggcatgc cttgttatcg agaaggcgtg
     8401 gatggtctct ttgtcggtta ttctaaaaaa gccggtgctt cttttgtagc tactagtgtc
     8461 gaaaatcaaa tgagggttat tacagtagtt ttaaatgctg atcaaagcca cgaggatgat
     8521 ttagctatat ttaaaacaac caatcaattg ttgcagtacc ttttaattaa ttttcaaaaa
     8581 gtccagttaa ttgaaaataa taaaccagta aaaacgttat ctgtcttaga cagttctgaa
     8641 aaaactgtca aacttgtagc ccaaaatagt ttatttttta tcaaaccaat acatacaaag
     8701 accaaaaata ccgtccatat tactaagaaa tcatccacaa tgatcgcacc tctatcaaag
     8761 ggacaagtct taggtagagc aacccttcaa gacaaacatc ttattggaca aggttatctg
     8821 gatactcctc cttctatcaa tcttatcctt caaaaaaaca tttctaaaag tttcttttta
     8881 aaggtctggt ggaaccgttt tgtgaggtat gtcaatacct ctttatagaa taacacaatg
     8941 ctttttgtat gacattgact gacagagtac ttctgcagtc tttttcattt ttatttaagc
     9001 aaactaggcc aatcctaaca atttttcaaa aaaacttcac attgtattag caaagtgata
     9061 tactgaaaat gcattacatt taaaggagtc ggaaattgac caaaagaatt atactaacta
     9121 tttttacctt tatttgcttt tcgatgatgc ctcttgtcca cgccgacgat gtcatggata
     9181 ttacaaggca agcaggctac acagttagtg aggttaatcg accaaaatct tctattgtcg
     9241 ttgatgcaaa tagttcagat attctttggc aagataatat tgatattcct agggatcctg
     9301 ctagtatgtc taaaatgttt acgctttaca ttttatttga agagctcgct aagggaaaaa
     9361 ttacgatgga cactactatt acggcaactc caaccgatca agctatcgct aacatttatg
     9421 agattagcaa taataatatc gtcgctggag tagcttatcc tattcgtgat cttattacta
     9481 tgacagctgt gccttcatca aatgcagcaa ctgttatgat tgccaattat ttatcaaaca
     9541 atgatgcttc tgcgtttatc gatcgtatta atgccacagc caaacaatta ggcatgacta
     9601 acactcattt ttcaaacgct agtggtgcag cagcacaagc ttttcaaggt tattataatc
     9661 ctactaaata tgatttatct gcttcaaata ttacgaccgc tcgagatttg tccaagttac
     9721 tctatgcctt cttaaaaaaa taccctgaaa ttatctcctt tacaaataaa tctgttgtgc
     9781 acactatggt aggaacgcca tatgaagaag aatttcacac ctataaccac tctctcccag
     9841 ataatcaatt tggtatgaaa ggagttgatg gattaaaaac aggttctagt cccagtgctg
     9901 cttttaacgc catgataact gccaaaagag gcaaaactcg actcattact attgtcatgg
     9961 gggtcggaga ttggtcagat caaaacggag agttttatag acatcctttc gttaatgcct
    10021 tgactgagaa agggtttaaa gatagtaaga ccttgtccaa aaaagcacgc caaaaactcg
    10081 aaaaattagt gccacaaacc aaaaaagaaa catcacctaa acagcagcac ttcaaagcca
    10141 ctaaaaagca atcgtacttg gaaagagtcg aagattttat gaattacaac catactttct
    10201 tgcttatttg cttagctatc tttataatta ctatcctttt actaagcctc gttgtctttg
    10261 caatgggacg ccaataatga attatcaaaa acctctgtca aagcacagag gtttttgata
    10321 tgttatctta cgtgtttaag gcaactaaaa actaaccact tggggttagt actacaactc
    10381 ataaaatcct atctcaaaga tctttcagat ggataagaga aaatgcaatt aaccgacaga
    10441 accttccatc tcataggaaa tcaatcgatt gagttcgacc gcgtattcca ttggcaattc
    10501 tttggtaaaa ggctccacaa atcccatgac aatcatctct gtggcttcgc tttctgataa
    10561 gccacggctc atgagatagt agagttgttc ttcagaaatc ttagacactt tggcttcatg
    10621 ttctaacgcc acctgtgaat tatgaatttc gttaaatggg atcgtatctg atttagaaat
    10681 atcgtccatc aaaatagtat cacattcaat atgggaaacg gattttttag attgcttgtt
    10741 aaaggtcact tggccacgat aatctacttt accaccagac ttggcaattg attttgacac
    10801 aattgatgat gatgtatgtg gagcattgtg aatcatttta gcccctgtat cttggtgttg
    10861 gcctgcgtta gcaaaggcaa tagacagcat ggtgccacgc gcacctggcc catcaagata
    10921 aacagaaggg tacttcatgg tggttttagc tcctagattg ccatcaatcc attccactgt
    10981 tgcatccgta agggcgcgtg cacgttttgt cactagatta tacacattgt ctgaccagtt
    11041 ttgaatggtg gtataacgca tgtatgcacc gtcaagcgca aagatttcaa cgatagcagc
    11101 atgtaagctg ttacttgaat aagtgggagc tgtacatcct tcaacataat gaacacttgc
    11161 tccttcatca acaataatca atgtccgctc aaattgacca gtattttcat tgttaatgcg
    11221 gaaataagtt tgcaaaggga tatctacctt gaccccttta ggaacataaa taaaggtacc
    11281 accagaccaa actgctgaat tgagggctgc taatttgttg tctgttggcg gaaccagttt
    11341 ggcaaagtat tgtttgaaca aatcaggata ttctttgagg gcggaatcgg tatctgtaaa
    11401 gataatccct agcttttcaa attcaccctt catgttatgg taaaccactt ctgactcata
    11461 ctgagctgat gctccagcaa gataagcacg ttctgcttct ggaattccaa tacgatcaaa
    11521 ggtttctttt attttttctg gaacatcatc ccaagaacga gctggcttat cagatgcttt
    11581 ttgatagtaa atgatatcat caaagttaat atctgataag tctgctcccc aggtttgcat
    11641 cggcatttta ttaaaggttt ccaaggattt taaacgaaac tccaacatcc actcaggttc
    11701 atttttggca gctgatagtt cgcgaaccac tgcctcactc aatccttttc ctgtagaata
    11761 aatgggctct acatcatcgt gaaatccaaa ttggtagtcc cctaagtcaa ttggctttgg
    11821 ctctactttc tcatttatat cagacatttt tcccttcctt tacattttgg tccgtgaggt
    11881 gctgagcatt ggcacttcgt ttaatggctt ccttgagagc attccaagct agggtagagc
    11941 atttgatacg ctgtggaaat tttgcaactc ctgccaacaa ttctgcttca cctagctctt
    12001 tttgagcagg attttcctgt ccttgtacca tctctgaaaa aatatcagct aacgcgagtg
    12061 cttcttcttt acttttacca ataacagcat ctgtcatcat gcttgatgaa gctgtggaaa
    12121 tggtacagcc gttgcctgca aaagcaatat cttcaatttt atcttcgtca aacttaacgg
    12181 tcaaagaaat cacatcacca caagtcggat tattcagtcg aacagcctct acgccatcta
    12241 gttgcccatg atgatgtgga cgtttcgaat ggtccgctac cacagccatg tatagatggt
    12301 tcagtttaga gagtgccatt gaaaaactcc tttgctttta gaattgcttc gactagacgg
    12361 tcacaatctg ccttggtgtt atagatataa aaacttgctc taacagttgc tggtacacct
    12421 aaataactaa gaagaggttg ggcgcagtgg tgccctgctc ttactgcaac accttcatag
    12481 tccaaggctg ttgccaagtc atgaggatgc aaatcatcca gattaaaaga aatcagacca
    12541 gatcttgcac tagactggct tggtccatat atggtaagcc cctcaatagc ttctaatttc
    12601 ggcaaaacat aggctattag ttctgcttca tgcgcatgta tatcagccat gcctagtctc
    12661 tgaaggtaag aaatggctgc gcttagccca atagcaccag ctatgtgagg tgttcctgct
    12721 tcaaacttcc agggcaattc tttccaagtg gcctcttgtt cgtaaacaaa atcaatcatt
    12781 tctccgccaa attcaagagg ctccacttga ttcaaaagct cttctttgcc gtaaagaaca
    12841 cccaaacctg ttggccccaa catcttatga gctgaaaaag caaagaaatc acaatccaag
    12901 tcttgaacat caatagccaa atgtggaacc gactgggcac cgtcaacaac aaggtaggct
    12961 cctttagcat gtgccagctt ggcaatttct ttaatgggat tgatgcaacc aagaacactg
    13021 gagacatgta ctaggctaac aaaacgtgtt tttgtcgtca atttgtttgt caaatcgtcc
    13081 atgtcaagtt ggccatcttt taaataaaca tagactaacc ttgctcctgt tttttgacag
    13141 gcttgttgcc aaggaatgat attggcatga tgctccataa tcgaaatcaa cacctcatct
    13201 tctggcgtca agacctgctc tgcaaaccga gcaacccaat tcaaactggt tgttgttcct
    13261 ctggtaaaga gcacttcctt gcttgattta gcatgaataa agtcagcaac gtgctggcga
    13321 ctggcctcat atttgtgcgt tgcacgttca gccaaggtat gaactcctcg gtgaacatta
    13381 gcattatctt cttgataata ggattgcaaa gcctcaagaa caagcgccgg tttttgtgtg
    13441 gtggcggcat tatccaaata aacaaggggt tcatcattga cttgttgatt taagatttga
    13501 aagtcttgtt tgatgtcttt tgcgtctagc aatactaacc tctttctttt tggcagtagg
    13561 tcttaacgat taagcaattt ctcatctaaa accttaataa tctcttggcg gactgatgga
    13621 ataggaattt cagcgataac cgctcctagg aatcctctaa taaccaatcg ttctgctgtt
    13681 tcttgatcca gtcctcgact catcaagtaa tacatatctt cagggtcaac ctgaccgata
    13741 gaagctgcat gacctgctgt tacttcattt tcatcaatta agaggattgg attggcatcg
    13801 gctcttgctt ggtcagaaag catcaaaaca cggctttctt gttgagcatc agctccctta
    13861 gcgcctttta gaatatgacc aatcccgtta aacgttaagg tgccacgttc caaaatcaca
    13921 ccatgctgta aaatatgacc gaccgtacgt tgaccatagt tggtcacgcg cgtgtcaata
    13981 ccttgtacct gacgaccact tgaggctgca acaactttca aatcagcttg tgagccctga
    14041 ccaatcaaat cactgtcaaa atcagcaatg acattgcctt cattcatcac agctaaggtc
    14101 caatcaatgt tggcatcctt ctctaaacgt cctcgacggc taatataggt tgtcactgaa
    14161 ggacctaagc ggtcgatagc cgagaattta atctggctgc ctgcttgagc aatcacttct
    14221 acactgatat tagcgctggt cttttgagtg gcattgccaa tagattcaaa acgctctaaa
    14281 taggtgaact tactttcttt tcctgcaatc actagaacat gcttgttaaa aggaacgtca
    14341 ctgtcactat cttgtaagaa aatagcttca ataggagttg tgatttccaa gtgatcagga
    14401 acgtagagca cggctgcgct attaaaataa gcagtgtggt aggcagctag tttgtcttca
    14461 tcaaaagcta atgcctgacc aaaatgagct tcaattactt ctgggatttc ctcaagcgcc
    14521 gtataaaaat cactgaaaac aactcccttg tcaattaacg ccattggtaa ctgttctaag
    14581 actgtttgcg tgcctacctg aacaagcttt gggttatctc caatagctat aaaatctgga
    14641 acactagcta gactttcatt ttctgttaag gtaccatctc ctagattcca acggtgaaat
    14701 ttaacccttt cgatggttgg taattccaaa tttggaatgg cttctaatgc cgctaaacgc
    14761 cgttcttgca gccaagcagg ctcagcgtgg gcttgcgaaa aagccactag tttttctttt
    14821 gtcatctgtc aatcctttgt ctctggtttt taaattggct gggtatatag aacatcacct
    14881 agctttttgt agaaagctaa agtaattgtc tccaaaaact taactttctt ccttatactc
    14941 gattcccaga tcctgtgcaa tacctgcgta gccttctttt tcaagacgag tagccaaggc
    15001 agcatcacca gataagacaa tacgaccatc catcataaca tgaactaggt ctggggtaat
    15061 gtaattcaac aaacgttgat agtgggtgat aatcatagct ccaaagtctt tcccacgcat
    15121 ctcattaacc cctttagaga ctacttttag ggcatcaata tcaagaccag aatcaatttc
    15181 atctagcaaa gcaaatttag gctctaacat gagcaattga agaatttcat tgcgtttttt
    15241 ctccccacca gaaaaacctt cattgaggta acgctctgcc atctcttctt tcatacctaa
    15301 caaagccatt ttctcatcaa gtttggtgat aaaatctcgc acggaaatct tatcctcatc
    15361 tgccttaccg gcattcattg ctgcacgcat aaattcagcg ttggtaatcc ctggaatttc
    15421 tgaagggtat tgcatggcga gaaaaagtcc cagtctcgca cgctcatcaa cttctagatc
    15481 gagaatattg accccgtcaa gcaaaatctg cccttgggtc acttcgtagt taggatttcc
    15541 cataataact gctgaaaggg tagactttcc tgtcccattt ggccccataa tggcagctac
    15601 ttccccagtt ttaagagtta ggttaacccc tttcaaaatc tctttacctt ctattgaaac
    15661 atataaatta ttaatctcaa gaattgacat gatacacccc ttattttctc tgtcatctat
    15721 accatctcaa gaaaagacag tgtcatttgc actgcttttt ttataatggt cactgcatct
    15781 attatagcaa aaaaagcctt actcggcttt tttagtgttt caaatccttc ttttctttcc
    15841 atttcagaag cattgcttga cgataatcac tattaccaat aaactttaac aagttaaaca
    15901 aaggcgttcg cttttcaccc cagatttcca atccttcaat aaaaacttct aaaccaaata
    15961 aaagtccaag gatcaagagg acgccaccaa ttcgactaga aacatttaaa agtaaagaaa
    16021 taagggaaaa aagcatggta ataccataaa ctactaagac agctcctcga tgagtaaagc
    16081 ccattgataa gagtcgatga tgcaggtgca tcttatccgg ctcgtagaat ttttgacctg
    16141 ataaactacg tcgaataata gccacgatgg tatccataat gggtacacca agaataataa
    16201 caggtgtcac cacagccaca gccgttgaat ttttcaatcc ttgaagagac aaaaccccta
    16261 tcataaagcc aataaagagg gctcctgtgt cacccaaata aatcatagct ggatggtaat
    16321 tataaggaaa aaatcctgca atagcagcaa tcaagaccaa aatggttaac gtcaaaaaga
    16381 aatctttttg aggtaaaaag aaataagata caatagccat ggtcactaaa ctaataatag
    16441 agaccccact aaccaaacca tccaaaccgt caatcaagtt aatagcatta gtgatggaaa
    16501 caatccacag gactgttaag aataaggtta agaaaggacc aaaaactaac aacggccctc
    16561 caaaaggaat tttgaagcta tcaaatttaa agtcggtaaa agcccagaca atcactgcac
    16621 caattagaat accaaacatc tttaatttag gacttaactc atacaaatca tctaaaaaac
    16681 cagtaagggt aattactgta gcaccaatca cgacaggtaa aatataactg aagtaggtct
    16741 gaccaaaaaa catggcgcct ttagaagcaa tcggaataag tcccaaactt gctactaaaa
    16801 aagacataaa aatagctaat ccaccactgg ttggcatcgg aaccttattg acccgtctgg
    16861 cattgggatt gtctactgca cccacacgaa aggctaaaaa gcgaacaaga ggggttaaga
    16921 ataaggacat taacaaagcc cctatcagaa caaggacata atctattgtg aatgaaaaca
    16981 tactatttta tcccaactca atcttttgta attgctcaac agcaccatca agcatcaatt
    17041 gtaagccatg ctcttgtaaa taagctcttg tttttgatcc agggtttgca tgctcaatca
    17101 atctcgcata catgacattc gcaaaataag atggttgttg ctgaacatct aataaaatag
    17161 tcatatggta gcagttgctc cccttatata actctgaagc ttctatcgaa aaatcaatcg
    17221 ttttagcaaa agccactgcc tctgtaatcg ttgaaaaatc caatacataa tggatatagt
    17281 ctaaaggttc tgaatcatga ttagttgatg gatcagccgc ttcagactga ttagctagag
    17341 tggcttcaac aacatcttcc attatctctt caattttttc caatttttca tgagctttga
    17401 catctccctt ttcacgcatg gattgctcca agctcttgaa aaaatcttcc ggagtcattt
    17461 gggacatatc accaaactct gctaaatctt caagattaat atctttattt atctcagatt
    17521 tggtaacaaa aacatctaga cggtccttgc gtggagtcac tcgaaaacta agcataccac
    17581 tatctttaaa attatctgga agatcgagtt cgtccatcac agaatagaaa aactcttctg
    17641 ttttttcttg aggaatcaag aaatctttca actccattcc tctttcttct aaatcgtcca
    17701 tactaattgt tatttttagc gttgtctcgc taatttgttt catttccatt atcaatacct
    17761 cgcacgcgta gtcattttat tatactagaa atgctgtaat ttcgcaattt atgactaact
    17821 cctcttctac aaaaggaaat ttaaaaagcg acagtcccca aggtctgtcg caacatccta
    17881 aacgatatgt aagtttaaaa aacaaattta aagaagctat aaataagtaa aaggcttcct
    17941 aacacaatac ggtatttccc aaaaatggtg aaatcgtgtt tcttaacata atctgtcaag
    18001 aacctaatcg ccaataaact aaccacaaaa gcggtcaagc tagccactaa aagaataagg
    18061 acttgtgcaa aatcaaggtg atggccatca aggaaaaatt tcacagcctt taatccacta
    18121 tatccaaaca tggtaggaat ggccaaaaag aaggtgaaat cagcggccac tgttcgacta
    18181 gttcctaaaa taatagctcc taagatggta gcccctgatc gactagtacc aggcacaata
    18241 cttaagactt gaaaacaacc aatgaagaaa gctgttttgt aagacattct agctaagtca
    18301 gtgacggcag gttcttgttg agcattttgt ttttcaatcc agataaaggc aatcccgtag
    18361 acgattaaag cgatggcaat cggaaccata aaataaaaat gtgcttcaaa ccaattatca
    18421 agaggaaccg ctattaaaat agaaggaata cacgcaatca ccacttttag ccataattgc
    18481 caggtaagct gtacttctct tgctgttttc ccaggttgga agggattgag acgttcaaaa
    18541 taaatcaaca taacagcgat aatcgcccct agttgtataa cgatattaaa catttctata
    18601 aaagccttat cctgatttag tcggataaat tcctgcacta aaatgaggtg accagtgctt
    18661 gaaactggta accattctgt gattccctca atgatgccaa agaaaatggc ttttagcaat
    18721 tcgattatta acatgttttc tccttattaa ccactcttat tgtgattttc taaactgtga
    18781 ttaatgccaa gcagcttttt taaaaggcac cgccgccgcc tcctccgcca ccgccagaga
    18841 agccgccacc accactaatc ccgcctccgg aagagactga gaaatttgag gaagttgtag
    18901 ctgaagacaa gctagacaca aaggttagtg tcgtagcata cattaccatt gataattcac
    18961 ctggtcgaac agcttggtaa acctcaggta aggcaatacg atggactttc aaatagcgtt
    19021 ccactttctt agcgtaacca aataaggtgg cataaaccaa aacacggttc caaacaacca
    19081 aaccttcaat agcaacatcc tcaaatttgt caatgtctcg tatcatgttt ttaaagctct
    19141 gctattgatg taaccgaaca cccccctcag gtgtttcaat acccaatttc ttgtattgat
    19201 ctaacttcag gctaatgtaa aagccaaggc acatcgttag caccattaaa gcaaggtaaa
    19261 tgagggccaa cccacttcct ttcatagtca gatagatcaa taaactacta ttcagaacaa
    19321 ctaacaagca gcctaacccc tggacactat gactttttcg tttctctgcc ggggtcattt
    19381 gacgataagt atctggcaag tttaactttt tgatagtttc taggacattg tttgtaatag
    19441 ttgccgacgc ttttttcatc gccttaatca cctgctcaga cgattgacgg acttcttgct
    19501 cgagcttttt acctttgtac gttttcttta attgtttaat ggtatcagca tcataatggt
    19561 attgactaaa caattgatcc accggcaatg tcaccttgtt tccaaaagcc atatctaaga
    19621 aggcagcttc ctcatctgtc acacgatcta actgactgat ttcaagataa gctttccctt
    19681 cttctttcgt taataaaagc accttttggt cgatcagatc caacaaggta gcttgaacaa
    19741 gggcctcaaa ggtcactcct ttagggatca ataatttctg actttctgat gctgtagggg
    19801 ataaataggc aaaactctgt ccataaatcg cttgtgtcaa cacaagaggc gaaagatctt
    19861 cagggacttc gtaactgtga tctgtatggt tggccaaatg ataacgattg aattgtttct
    19921 ttaatcttgt aaactgtatt aactgccaaa gaagaaaacc tacctctacc agaggaatga
    19981 ctttgccaaa tagcagctgt aacaaggccc ttcgtctgga aatcttagtt tctaacgcta
    20041 caattttatt ctttttactc gttgaaacat caactggttc ttctcccaat aatgcttttt
    20101 tatcccaata agcatgcaat tccaattgcc ctgagacatt tttggcatta atctgatagc
    20161 gactgttacc ttcttttaac acttgaggtt tcttttggta atatcctctg tgagcccata
    20221 gattagaatc ctgaatatca gttggggtag taacggtcaa actcaccttt tctaatgttt
    20281 tgtcccagtc actgatcggt gtccaattca gctctgccac gtcttgataa gctgttaaaa
    20341 ggtggtgcag ttgccaggta accttaacgt caaccttatc accagcttgg ccagcattat
    20401 aaagttttaa acgatagcca tctccaaggt cactaaactc ttgactaaca ggtacctgtt
    20461 gaccattctg atatacctca actttaggct tttggtcaat agcaaagccc gctggcaaat
    20521 gacctgcccg gcccagcgaa atatactggc cgttataaga agtgtcaaat tgataggtta
    20581 ctttttgctc aaaccgagca gtattttctt ttgataacag taactgacct tcatagttgg
    20641 tgatgctata gtctacatca gctgctttta ttcgtatccc taaaagactg aagcagagca
    20701 caagcgtcat cagaattttt ttcatggtaa catcctcttt ctgccctcat tttaccatat
    20761 tttaaggaga tgacaaaacc taaaccaagt ccttcatctt atttttaatc attattttga
    20821 atatttttcc atatttcaac ctattcactg ataatatatt gaaataggat gcaaattgct
    20881 gtaaaatagg tctgaatact atttttgaaa caggagacct atatgaaaaa gctaatcctt
    20941 agctgtttgg tcgccttggc ccttctgttt ggaggaatga gccgggctca agcaaaccaa
    21001 tatttaagag tcggaatgga agcagcctat gctcctttta actggactca agatgacgct
    21061 tcaaacgggg ctgtccctat tgagggaact agccaatacg ccaacggtta cgatgtccaa
    21121 gtcgctaaaa aagtcgctaa agctatgaac aaagaactgt tagtcgttaa gacctcttgg
    21181 accggtttaa ttccagcatt aacttctgga aaaatcgata tgatcgctgc tggtatgagt
    21241 tctaccaaag agcgtagaaa cgaaattagc ttctcaaaca gctactacac tagccaacct
    21301 gttctagtcg taactgctaa tggcaaatat gctgatgcaa caagcctcaa ggatttttct
    21361 ggagctaaag taactgccca gcaaggcgtt tggcatgtca atctcttaac tcaactaaaa
    21421 ggtgctaagt tacaaacacc aatgggagat ttctctcaaa tgcgacaagc ccttacttcg
    21481 ggtgttatcg atgcctatat ttctgaacgg cctgaagcca tgactgctga agctgctgat
    21541 agccgtttga aaatgatcac tcttaaaaaa gggtttgctg ttgctgaatc agatgctgct
    21601 atcgctgtcg gaatgaaaaa aaatgacgat cgtatggcaa ctgtcaacca agtgcttgaa
    21661 ggattttctc aaacggatcg tatggccctg atggatgata tggttaccaa acaacccgtg
    21721 gaaaagaaag ccgaagatgc taaagcatca tttctaggcc aaatgtgggc tattttaaaa
    21781 ggtaactgga agcaattctt acgtggaact ggaatgaccc ttctgatttc catggtcgga
    21841 accattacag gtctctttat tggattatta atcggtattt tccgtacagc tcctaaagct
    21901 aagcataaag tagctgcctt gggacaaaaa ctctttggtt ggttactcac tatttacatc
    21961 gaaatcttcc gtgggacacc tatgattgtt caatctatgg ttatttacta cggaacagcg
    22021 caagcctttg gtatttcgat cgaccgtacc ctagcggcta tttttatcgt atctatcaat
    22081 acgggtgcct atatgagtga aattgttcgc ggtggtattt tcgctgtcga caaaggtcaa
    22141 ttcgaagcag caactgctct tggctttact cacggacaaa ccatgcgtaa aatcgtgcta
    22201 ccacaagttg ttcgcaacat tttaccagca acaggtaatg agtttgtcat caatatcaaa
    22261 gatacttctg tcttgaatgt tatctctgtt gtggaacttt acttctcagg taataccgta
    22321 gccacacaaa cctaccaata tttccaaacc tttacgatta tcgccattat ctactttgtt
    22381 cttaccttca cggtgacacg tatccttcgt catattgaac gccgtttcga tgccgatact
    22441 tacaccactg gagcaaacca aatgcagatt gcggaggtct caaatgtcta actcaattat
    22501 tgaaatcaaa aacctcaaaa aatcttacgg cagcaatgaa gtactcaaag atatctccct
    22561 ttctgttaac aagggagaag tcatttccat tatcggttct tctggttctg gaaaatcaac
    22621 cctcctgcgc tcgatcaatc ttttggaaga gccaagtgcc ggtcaaatcc tctttcatgg
    22681 tgaagatgtc cttgctgaac actacaactt gactcactac cgtgaaaaac taggcatggt
    22741 tttccaatct tttaacttgt ttgaaaacct aaatgtattg gaaaatgcta tcgtcgctca
    22801 aaccaccgtc ctcaaaagag accgtccaca agccgaacaa atcgctaaag aaaacctcaa
    22861 tgcggttggt atgacagaac aatactggca agccaaacca aaacaattat caggggggca
    22921 aaaacaacgg gttgccattg ccagagcctt atctgttaat ccagaagcca tgctctttga
    22981 tgaaccaaca tcagctcttg atcctgaaat ggttggtgag gtccttaaaa ccatgcaaga
    23041 cttggcaaaa tcagggttga ccatgattat tgttacccat gaaatggaat ttgctcgtga
    23101 tgtttctgac cgtatcatct tcatggataa gggattgatt gctgaagaag gaagtcctca
    23161 acaaattttc gagaatccta cacaagatcg taccaaagaa tttttacaac gcttcttaaa
    23221 ataagataaa ggatccaact atttctatgc cagttgggtc ttttttcaat tcaaaaagaa
    23281 tttgtcataa aatactttac cagttaacta ttttatgcta tacttatttt tgttaacgtt
    23341 aataatttat atttaggagg ataatatggc agaaaaaact gacttatcgt cagcttacag
    23401 aagactgaaa agtcccaata ttaaaaccag aaaacgtgct ctgaagatta ttcacgagta
    23461 caaacgttac ggtaaaaaat aagattttac tttttatctc tccaaattta agtcagacaa
    23521 aaaaaggcta agacacccct tccatcttag cctttttgta tacagtttat taagggaact
    23581 attttaaaat atcttttatg ctagggtcta gaatagttca aaacgttaaa atcatacatt
    23641 taaggtagtg tttaaagtat acgaaaaaga actcagcata aaccaagctc tctttcgtta
    23701 taactaatta tttagcaatt tttgcgaagt actcaagagt acgtacaagt tgagcagtgt
    23761 aagacatttc gttgtcatac catgatacaa ctttaaccaa ttgtgatccg tcaacttcca
    23821 ttactttagt ttgagttgcg tcaaacaatg aaccgtatga tacgcctacg atatctgaag
    23881 aaacgattgg atcttcagtg taaccgaagc tatcgtttga agcagctttc atagcagcgt
    23941 tgatttcgtc aacagaaacg tttttgtcaa gagttacaac caactcagtt actgatccag
    24001 ttggaacagg aacacgttgt gcagcaccgt caagtttacc gttaagttct gggataacaa
    24061 gaccgatagc tttagcagca ccagttgagt taggaacgat gtttgcagca ccagcgcgtg
    24121 cacgacgaag gtcaccacca cggtgtggtc cgtcaaggat catttggtca ccagtgtaag
    24181 cgtggattgt agtcataaga cctttttgaa taccgaatgc atcgtgaaga gctttagcca
    24241 taggagctaa acagtttgta gtacatgaag cacctgagat aactgtttca gtaccgtcaa
    24301 gaatgtcgtg gttagtgttg aaaacaactg ttttaacatc gtttccacca ggagctgtga
    24361 taacaacttt tttagcaccg ttagcatgta agtgtttttc agctgcttct tttttagcaa
    24421 agaaaccagt tgcttcaaga acgatttcaa ccccatcagt tgcccagtcg atgttttctg
    24481 gatcacgttc agcagaaact ttgatgaagt ttccgtttac ttcaaatcca ccttctttaa
    24541 cttcaactgt tccatcaaaa cgaccttgag ttgtatcgta tttcaacaag tgtgcaagca
    24601 tatttggatc tgtaaggtca ttgatacgag ttacttcaac accttcgatg ttttgaatac
    24661 ggcggaatgc aagacgtccg atacgaccga aaccgttaat accaacttta actaccatta
    24721 gtgatttcct ccttatgaaa atcaaaagaa tattatttag agggaatgct ccctacctat
    24781 tgtgaaaaga ttaacttaca gtcatctgca acaacctttc aacagaacta ttatataact
    24841 atttcagaaa aaatgcaaat aaattagcca ttttcataaa gggcagcttc tttcttctag
    24901 ccttcaaaac ccaccaaata taggaaaggg ctttcttttt tctattctgt aatttatctt
    24961 tttattggga aagatttcca aaacttcaaa ctgtactata acgttctgtt acactaaaaa
    25021 agaggttagg atagttatcc tcaacctctt agtggtggtt attcaccttt gtttttctta
    25081 atgatttctt cttgaactga cttaggaaca tcttcatagt ggtcaaatac catcatgaac
    25141 gtaccacgtc cttgagttgc agaacgaaga actgttgcat aaccgaacat ttcagcaagt
    25201 ggtacataag cacgaacgat ttggctgtta ccatgtgctt ccataccatc aacgcgtcca
    25261 cgacgagctg tcacgtgtcc cataacgtct ccaagattat cttctggagc tgtaatcgtt
    25321 acaagcatca tcggctcaag gatagctggt tgtgcagatt tagctgcttc tttaagtgca
    25381 agtgatgcag ctatcttgaa ggcagtttca gatgagtcga catcgtggta tgaaccatcg
    25441 taaagcttag ctttaacatc aaccattggg taacctgcaa gaacaccgtt tgccatagat
    25501 tcgatcaacc ctttttcaac agctgggata aattcacgag gaaccacacc accaacgata
    25561 gcattttcga attcgaaacc tttaccttct tcatttggtg taaattcaat ccaaacatca
    25621 ccgaattgac ctttaccacc agattggcgt ttgaagaatc cacgagcttg tgtagaagca
    25681 cggaatgttt cacggtaaga tacttgagga gcaccaacgt tagcttcaac tttgaactca
    25741 cgtttcatac ggtcaacaag gacatcaagg tgaagttcac ccataccagc gataactgtt
    25801 tcaccagttt caacgtttgt ttcaacgcgg aatgttggat cttcttcagc aagtttttga
    25861 agggcaacac ccatcttgtc ttggtctgct ttagattttg gctcaaccat caactggata
    25921 actggttctg gaacttcgat tgactcaaga ataacttttg ctttttcatc agtcaatgag
    25981 tcaccagttg ttgtgtcttt caaaccaaca gcggcagcga tgtcaccagc gtaaactgtt
    26041 tcaatttctt gacggctgtt tgcgtgcatt tgaaggatac gtccgatacg ctcacgttta
    26101 ccttttgatg tgttcataac gtaagaaccg ctattaagaa cacctgagta aacacggaag
    26161 aatgtcaaac gacctacgaa tgggtcagtc atgatcttga aggcaagagc tgcaaatggc
    26221 tcttcatcag atgctggacg ttcttcttca gcatctgtat ccgggttaac acctttgatt
    26281 gcagggatgt caagtgggct tggaaggtat gcgataaccg catcaagcat caattgaaca
    26341 cctttgtttt tgaaggcaga accacaaagt actgggaaga attcaacgtt gattgttgct
    26401 ttacggatac cagcaatcaa ttcgtcgtta gtgatttctt caccttcaag gtatttcatc
    26461 atcaagtctt catcagtttc agcaactgct tcgattaatt tttcacggta ttcttgagct
    26521 tgttctaagt attcttctgg aatatcttct tcaagaatat ctgtaccaag gtcgttggta
    26581 tagatttctg ctttcatctt gatcaagtca atgataccac ggaaatcatc ttctgcaccg
    26641 attggcaatt ggattgggtg tgcatttgct tgaagacggt catgaagggt ttgtactgag
    26701 taaaggaagt cagcaccgat tttatccatt ttgttggcga aaacgatacg tggaacaccg
    26761 tattcagttg cttgacgcca aactgtttca gtttgaggct caacacctga ttgtgagtca
    26821 agaacggtta cagcaccatc aagaacacgg agagaacgtt gtacttcgat ggtgaagtcc
    26881 acgtgtcctg gtgtgtcgat gatgttaacg cggtgaccat cccattgagc tgttgtagcg
    26941 gcagaagtaa tagtgatacc acgttcttgc tcttgctcca tccagtccat ttgtgatgcg
    27001 ccttcgtgtg tttcaccgat tttatgaatt ttaccagtgt agtaaaggat acgctctgtt
    27061 gtagttgttt taccagcatc gacgtgagcc atgataccga tattacgagt ttttgcaagt
    27121 gaaaattcgc gagccatgtg tttctcctat ttttttagtt tactctttca ttatagcact
    27181 atttagcaaa aacggatagg caggacctac ccgttatcta aatatttgtt ggtaaagata
    27241 atacctattg cctttataag gcttggtatc ttattcattg aactcgggct aaacgctgtg
    27301 tgaaaaagat aaactttcct agagacaaag gtttcttcgt caaatttcct attttcactt
    27361 tgcgttctat acgccttcgt atcttattaa ttgagttcga gctacaagcc actgacaaaa
    27421 agataatagt tcctagaaac tgaagtttct gcgtcactat tcctattttg tcttggactt
    27481 gcttaacact ctcacatctt atattagttg aattttagct acaaatgtct gccacaaaga
    27541 taaaattacc tagaaactga agtttctgcg tcaatttccc tattttggct agcatttgtt
    27601 tgacgctaaa atatcttata ttaccaacgg aagtgagcaa aggcacggtt agcttcagcc
    27661 attttgtgag tgtcttcacg tttcttaact gatgcacctg tgttgtttgc agcatccatg
    27721 atttctttag caagacgatc tttcatagtg tgttcaccac gagctcgtga tgcgtttacc
    27781 aaccaacgaa gtccaagtgt tgtacgacgt tctggacgaa cttcaactgg gacttggtag
    27841 ttagaaccac cgacacggcg tgcgcgtact tcaagtacag gcatgatgtt gtccatagct
    27901 gtttcaaata cttcaagagc gtcatttcct gttgcttctt tgatagcgct gaaagcatcg
    27961 taaacgatag tagcagctgt accacgttta ccgtcaagca taacacggtt gataagacgt
    28021 gttacgattt ttgagttata taatggatct ggtaatactt cgcgtttagg cgcttgattt
    28081 ttacgactca ttttctctta tcccccttct attatccttt tggacgtttc gcaccgtatt
    28141 tagaacggcc ttgtttacgg tcagcaacac ctgcagtatc aagtgcgcca cgaacgatat
    28201 ggtaacgtac ccctggaagg tcttttacac gtccgccacg aataagaaca acactgtgct
    28261 cttgcaagtt gtgtccgata cctgggatgt aagctgtaac ttcaataagg ttgctcaaac
    28321 gtacacgagc gaatttacga agggctgagt taggtttttt aggtgtcatt gttccaacac
    28381 gagtagcaac gccacgtttt tgtggggcag ccattttagt ttgaactttt ttgtgactgt
    28441 tgtaaccaat gttcaaagct ggtgaatctg atttttcaat tttagattta cgtggtttac
    28501 gtaccaactg gttaattgta ggcatctaca ttctcctgtg tttttttatt tttggttgat
    28561 atagcacttg gtgacagccc atatccggtg cactttttgc aacaattgtc agcacgtctc
    28621 tgtacacttt tgagagacca aaagtaaaaa gtaccgtcta atataataac acagacggta
    28681 cttcatgtca aatagaattt ttcctttgat gcaattgctt atgacgaatg catcacttag
    28741 attccttacg gaacctaaat cctgtgaggc cgacagctgc caacatgacg actcctgctt
    28801 taagagctct ttgagtactt tcatcaacat cagaaatgag attgctcgtt gtagaagatc
    28861 ctgagccata agatgtctta gatgagggct gagtaatcga agatgtgatt ttagacacaa
    28921 tggcattact tgctaccatt tcagaggttt ggccaacaag cgcttctgct acaagacttg
    28981 tattttcagc agctaatctt gctgaagctt ctaatagttg tttcgtttct ttaaccattt
    29041 cttgaacaag cggagtagta tctatcttac tatatgatag cggttttacg cccgtaagag
    29101 gtggagctac ttgcaaatca ggcacagtag ctatatcttc gtctaaatgg cgatattcct
    29161 tttcattagc taaggtttta agcaaagtca actggtgttc tgtggtagca atagtagctt
    29221 ctagaccgct ttgtttagct tgtaaggctg ctaaagtttc ttgtgcattt aacaaagatg
    29281 aggtagtttt agccaaatct tgcttagtat tatcaatgcg ctcacgtatc acttgaaggc
    29341 ggttaggatt caatttaaag tcccttagat attgcaaatg agctttttta gccaccagtg
    29401 ctgtcactct ggctgcggct tgctctgcta aggcttctgt ctggtgcagt gcggctttca
    29461 acgatgctag cttagccaat gattgatcac gagtagcttc gagttgtgct tgttttgctt
    29521 tagctgctag taattctgtt ctcaaagaac ctttagtatc atttaattgt ctcacttgga
    29581 ggtttaagct gtctgactgc ttaagtgtgc ttgctaattt accttgaagt tgacttactt
    29641 tagcttgggc tgccataata tcagcttctt gatgaatagc cgacaaacga ttttctaatg
    29701 agcttacttt tcctttgatc gctgcaatag tatcagatac agtgcctact ctttgggcat
    29761 aatcttttgt acttccaacg gcttttatag gggtcttatt aaagcgttga tggttagcaa
    29821 tgttagactc tggaaacatt acaaagtgtt cattcaaaga tcctacattg ctggttgaaa
    29881 atccaaggta aacaggcgca ttagggttac gtttatctac acgtaaaaag ttaatagcat
    29941 ggccgtatgt atttccgtgt aaatgatctg taaagagcat atacttgata ctgtcataaa
    30001 taccacgttt aataccattc acagtatgca catcgttaaa agcaccgata ttctcgtaca
    30061 tgttatcatc atttcgaatg agccctgacg ctccggcaga gtcttcaata atagttttat
    30121 catgaggccc aacaccataa tgccctgata cccctggctg tccgtagaca aatgatggtc
    30181 ttgtattacc atgagttttc ttatagctgg tactaagtaa tcttgcaaat tcttgtgatc
    30241 ctgctgtaac agtaactggt ggtagaccta attgtcttct tacactatta atcatgtgag
    30301 ctgcaaactg cgctagctca ttttgcactt ctggtgtcaa attatcggga tcaacaaagc
    30361 gattacgatc tgctggaata tcttggtatt gatttaattg attacctgga ctagctttgg
    30421 caataatttg atctgcatgc tctttgtaat aattattgta actagctgat ccaatataac
    30481 cactagcttc taatttttta agttcttcaa gaggatagcc ttgcggtgct ttcatggtat
    30541 tattacccac aatgctatct tgagtagacg gagctgagga tttaagacga ctaagttctg
    30601 cctctttttc tgctagagca gctttctgag ctgccaactc ttcagtcaat tgctttttaa
    30661 ctttagcttt ttgattttct aagtcagctt tagccttctc caattctgag cttaatgctt
    30721 ttgtattatc attagccgtt tgagctgctt tagtgatagc atcaggattg ctaatcatag
    30781 cattgagctt agcaatattt tgttcagacg ttttgacttg ttccactaaa tcttgagctc
    30841 gagtagtttc tgctgaaatg ctagcttttt gttctgacaa tgcagtctct tttgaatgtt
    30901 gatctgcttg agcattatga agctctgttt cagtagctgt taactctctt tgatgttcgg
    30961 ctccttgggc taatagcgtc tcctcactac ttgcaagagt attagtgtaa atttcttgtg
    31021 cagaggttaa agctttttgt tcattatctt gctgctcttt taagtggttg atttcagcag
    31081 tagtttttgt cagagcggta gcaagctttg tcagttctgc tttttgttga ctgagagttt
    31141 tttcaactgc atcaatagtt gcctttgcct cttgaattgt ttctggtttt ggtaaactat
    31201 cgtcgtgagt attactcgcc ttcgtttctc ctgaggctct atcatctgct ttgacttggt
    31261 gagatacgcc tacactggca ctcaataaag caattgttga ggttaaagca attttctgct
    31321 taacttggtt tggcttcgtt tgctctaagt ccattctctc tcctttttcc atttatcgaa
    31381 aatattacca acttctacaa caacattgtt gtttttgaca tcaatctctg aaactttcag
    31441 caatgatttg aaggtcattt gctcacgctc tgattgagcg ttttctgcaa acacagcaac
    31501 accaactaaa gtgctgtcaa attctgtcaa gagactgatc attcctgtaa tcgtcccccc
    31561 gcccttcaag aaatcatcta caatcaatac acgactattg ggtttcaaac tacgctttga
    31621 cagaaacatc ttttcaatac gatcactaga agcactcgca taattgacag acactgtcga
    31681 tccttctgtt atttttaaat cacgtctaac aatgacaaaa ggaacactta aaatattagc
    31741 cactgcattt gctaaaggaa ctcctttggt tgcaactgtc atcacagcgt caatcttttc
    31801 tcctttaaag gcattggcaa taatacgacc aatattttgt aaaattttag gtgtactcag
    31861 caagtctgac aaatagatat agcctccagg taagatgcga tcactctctg ataacctttg
    31921 acacaggtct tcaacaatgg tacgcgcttc tgtttctgaa atactggggg taaaaattac
    31981 gcctccactt gctcctgtaa gtgtatcgat atcaccaatg ttaccttctt caaaagcttt
    32041 cttgataata gcgatatctt ctgagataga agattttgcg gcctcatatt tagttgcaaa
    32101 ggtgtttaaa ctagttaatt tatacggatt gttaatcaaa taatttgaaa tgacaaccat
    32161 acgttcactt cgtcttaatt tcatagtttc cccatttttt tgtacttttt gctattatac
    32221 cataaagtta ataaaaaacg aacattcgat taggaaaata ttgg
//
LOCUS       DAUDWO010000024        31213 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.024, whole genome shotgun sequence.
ACCESSION   DAUDWO010000024 DAUDWO010000000
VERSION     DAUDWO010000024.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 31213)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31213)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31213
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.024"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            69..842
                     /gene="cfa"
                     /locus_tag="VHC05_001061"
     CDS             69..842
                     /gene="cfa"
                     /locus_tag="VHC05_001061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_149017463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CAMP factor pore-forming toxin Cfa"
                     /protein_id="HEQ5402378.1"
                     /translation="MKPKHLLCLSTVVAGLALFSTMTHSVLADDASNPDTILMNNNQA
                     NLQRDALVQKLDEGHQQLEAIKHEAKGTDIEATVNKAIDAVDHMKSSIRFNTETIYDF
                     SSIGARVEALSDAIKAIVFSTTQLTHKVEKAHTDMGFAITKLVIRIIDPFASVDAIKA
                     QVQEIKALEEKVINYPNLQPTDRATIYTKAKLNKAIWNTRLERDKKVLGIKSFDVYNR
                     LNKAITHAVGVQLNPTTTVQQVDDEVIAVQNALETALKS"
     gene            complement(1212..2447)
                     /locus_tag="VHC05_001062"
     CDS             complement(1212..2447)
                     /locus_tag="VHC05_001062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation diffusion facilitator family transporter"
                     /protein_id="HEQ5402379.1"
                     /translation="MTQDPIANLKLARKGPIVSIIVYLLLSAAKLLAGYLLNASSLIA
                     DGFNNLSDIVGNVALLIGLHLASQPADANHKFGHWKIEDLSSLVTSFIMFLVGFQVLI
                     HTIKSIFSGQQVDIDPLGAIVGIVSAFVMLGVYVFNKRLSKRVKSSALVAASKDNLAD
                     AVTSIGTSIAIIAASLHLPVIDHIAAMIITFFILKTAFDIFMESSFSLSDGFDSRHLK
                     KYEKVILEIPKIVAVKSQRARTYGSNVYLDIVLEMNPDLSVYESHSITEKVEQLLSDQ
                     FSIYDIDIHVEPAMILEEEIFDNVAKKLYRYEKLILSKVPDYDHYIAKSFQLVDANGQ
                     TVNYEQFLNQEIYYPSNFNHFQIESISQKTMLVTYQLNGNQHTSIWRRHESWSLLFHQ
                     ITPIAKRQLHHTHYRIVKM"
     gene            complement(2567..3889)
                     /locus_tag="VHC05_001063"
     CDS             complement(2567..3889)
                     /locus_tag="VHC05_001063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:alanine symporter family protein"
                     /protein_id="HEQ5402380.1"
                     /translation="MIALVKLIDNLVWGPPLLILLVGTGIYLTSRLGLIQILKLPRAF
                     KLIFSDDEGHGDISSFAALATALAATVGTGNIVGVATAIKSGGPGALFWMWVAAFFGM
                     ATKYAEGVLAIKYRTKDASGHISGGPMYYIVNGMGTKWKPLAILFAGSGILVALFGIG
                     TFAQVNSITSSLGHSFGLSPQMVSIVLAIFVAAIIFGGIHSISKVAEKVVPFMAIFYI
                     LSSLAVIFSHYQQLLPVIRLVFQSAFTPTAAIGGFAGSLMKDTIQKGIARGVFSNESG
                     LGSAPIAAAAAKTNEPVEQGLISMTGTFIDTIIICTLTGLSILVTGQWTGQLEGAPLT
                     QSAFATVFGNLGTFGLTFSLVLFAFTTILGWSYYGERCFEFLFGITHLTYFRIVFVLM
                     VGLGGFLKLELIWVLADIVNGLMALPNLIALLALSPVVILETKHYFIK"
     regulatory      complement(4017..4103)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            4419..6737
                     /gene="pcrA"
                     /locus_tag="VHC05_001064"
     CDS             4419..6737
                     /gene="pcrA"
                     /locus_tag="VHC05_001064"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase PcrA"
                     /protein_id="HEQ5402381.1"
                     /translation="MNPLLNGMNDRQAQAVQTTEGPLLIMAGAGSGKTRVLTHRIAYL
                     IDEKFVNPWNILAITFTNKAAREMKERALSLNPATKDTLIATFHSMCVRILRREADHI
                     GYNRNFTIVDPGEQRTLMKRILKQLNIDPKKWNERSILGTISNAKNDLLDEKGYEAQA
                     ADMYSQIVARCYKAYQEELRRSEALDFDDLIMMTLRLFDANPDVLAYYQQRYQYIHVD
                     EYQDTNHAQYQLIKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPDAKVVL
                     LEENYRSTKKILQAANDVINNNRNRRPKKLWTQNADGEQLVYYRANDERDEAVFVAST
                     ISNMSQELGKNFKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDLIA
                     YLTIVANPADNISFERIVNEPKRGVGPGTLDKLRQFAYESDQSLLEAASNLLMSPLKG
                     KAAQAIMDLANILGQLRQDLDQMSITDLAEALLEKTGYLDSLRLQNTLESQARIENIE
                     EFLSVTKNFDESSASQEEDETGVDRLGRFLNDLALIADTDDSQAEAAEVTLMTLHAAK
                     GLEFPVVFLIGMEEGVFPLSRASEDPDELEEERRLAYVGITRAEEVLFMTNANTRTLF
                     GKSSYNRPTRFLKEISEELLSYKGLARPAQSSFGVRFSTETHTQFGQGMSLSEALQAR
                     KTQAQVRQSAQPMQAHTIPSASTSSVLPFGSNSSVEEVTWQIGDIAHHKKWGDGTVLE
                     VSGSGKTMELKIKFPEVGLKKLLASVAPIEKK"
     gene            7101..7349
                     /locus_tag="VHC05_001065"
     CDS             7101..7349
                     /locus_tag="VHC05_001065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HEQ5402382.1"
                     /translation="MGLIWTLIVGALIGVIAGALTKKGGSMGWIANIAAGLVGSSVGQ
                     ALLGSWGPSLAGMSLIPSVIGAVIVVMITSFVLNKTNN"
     gene            7386..7997
                     /gene="amaP"
                     /locus_tag="VHC05_001066"
     CDS             7386..7997
                     /gene="amaP"
                     /locus_tag="VHC05_001066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkaline shock response membrane anchor protein
                     AmaP"
                     /protein_id="HEQ5402383.1"
                     /translation="MLSRKEVCMSKLLKISYCLVGLVLLSVFGWVVGITGGYIYLPYS
                     YRWLSWGMDSFPNLLDSALSYYYFWTALVLFVITFLALLVIILYPRIYTEVQLRHKNK
                     KGTLLLKKSAIESYVATAIQTAGLMPNPTVTAKLYKRKFKIIVKGRLASRVAVADQIS
                     GVKEGIEKGLTEFFGINYPVNFKVYVKDIADSDRKHITRNRVE"
     gene            8008..8196
                     /locus_tag="VHC05_001067"
     CDS             8008..8196
                     /locus_tag="VHC05_001067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2273 domain-containing protein"
                     /protein_id="HEQ5402384.1"
                     /translation="MEFYEKFKYPIIGGLVGLIIAILLMAFGLFKTLLAIIFIILGIY
                     GGLYAKKTGIIDQFLNRK"
     gene            8209..8748
                     /locus_tag="VHC05_001068"
     CDS             8209..8748
                     /locus_tag="VHC05_001068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015632041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEQ5402385.1"
                     /translation="MTETYIKNTSKDLTSAIRGQLTYDDKVIEKIVGLALENVDGLLG
                     VNGGFFANLKDKLVNTESVRDGVNVEVGKKQVAVDLDIVAEYQKHVPTIYDSIKSIVE
                     EEVKRMTDLDVIEVNVKVVDIKTKEQFEAEKVSLQDKVSDMARSTSEFTSHQVENVKA
                     SVDNGVEKLQDQKAEPRVK"
     gene            8789..8989
                     /locus_tag="VHC05_001069"
     CDS             8789..8989
                     /locus_tag="VHC05_001069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HEQ5402386.1"
                     /translation="MSDEKYNAKLDQAGGKLKEGFGKISGDKSLETEGKVDKVTGKVK
                     EVIADAKDTVKGLAKGLDNKDK"
     gene            9000..9488
                     /locus_tag="VHC05_001070"
     CDS             9000..9488
                     /locus_tag="VHC05_001070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEQ5402387.1"
                     /translation="MEKTQIKSTLTYDDKVIEKIVGHALENVGGLLAVTGGFFSNIKN
                     NLVNSESVTDGVSVEVGSKEVAVDLAIIVEYGKDIPAIAESIKAIVSQNVDSMTHLKV
                     VEVNVNVVDIRTKEEHEAASVTVQDRVTSAASSTSQFVSEQTEKLKDTISDTVNSDEA
                     AK"
     gene            9651..10292
                     /locus_tag="VHC05_001071"
     CDS             9651..10292
                     /locus_tag="VHC05_001071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEQ5402388.1"
                     /translation="MISPKKEITSSKYQKIAISVAQRIANGEYEVGEKLKSRTTIAST
                     FNVSPETARKGLNILADLKILTLKHGSGAIVLSKERAIEFINQYESTHSIAVLKEKIR
                     ETINDQGKAMEKMAVLVNDFLMQSQSVSKQYPLAPYEIICSQDSEHFGKSIGVLNIWH
                     QTGATIVAIEHAGQFIVSPGPYSVIEKGDHIYFVGDESVISRMKTFFNLRKGL"
     gene            complement(10435..10977)
                     /locus_tag="VHC05_001072"
     CDS             complement(10435..10977)
                     /locus_tag="VHC05_001072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEQ5402389.1"
                     /translation="MTKRHTETKAYVKTALTTLLTEQSFETLTVSDLTKKAGINRGTF
                     YLHYTDKFDMMNHFKNDTLDDLYRLLNQAEIYTDTRQVLNQTLSYLIEHREFITALAT
                     ISYLKFPQLIKDFCYQFLTTITGFQDIVTNQYHIPYPYALEVYLASIESIISYWIANG
                     YQETTEEVADIILKAVTLDN"
     gene            11095..11796
                     /locus_tag="VHC05_001073"
     CDS             11095..11796
                     /locus_tag="VHC05_001073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402390.1"
                     /translation="MAFIELKQVSKSYQVGETTVFANHEVSFEINKGELVVILGASGA
                     GKSTVLNILGGMDTVDAGQVIIDGKDIAHYTSKALTQYRRNAIGFVFQFYNLVPNLTA
                     KENVELAVEIVADALDPVTILKEVGLSHRLDHFPAQLSGGEQQRVSIARALAKNPKLL
                     LCDEPTGALDYQTGKQILTLLQDMARTKGTTVVIVTHNAAIAPIADRVIFMHDAQVTK
                     TVINKEPASIETIDY"
     gene            11811..14447
                     /locus_tag="VHC05_001074"
     CDS             11811..14447
                     /locus_tag="VHC05_001074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HEQ5402391.1"
                     /translation="MIKKTLWKDILRAIKNSKGRFISLFFLMALGSFALVGLKVTGPD
                     MERTASRYLERHQVMDLTVLASHQFSQADKQELDTLKGAHLEYGHLLDVSLTSNQKSL
                     RLYSVPKKVSKPVLVKGSWPKRETDLVLSSSLAKNYQIGDELVVTSPMEGLLTTTHFQ
                     VVGFANSSEVWSKSNLGSSSTGDGSLYAYAFVNPNVFKSAFNLLRIRFSNLRLTNAFS
                     KDYQKRVTQNQAHLDNLLKDNGQKRYDDLQNQYDLALKNGRAALAKETVKLAASEENL
                     TFLEGSALQEAKHQIEQGKQALAKEEKQLEQVQATKDKLEKPSYLTYNRSTLPGGEGY
                     HTYATSTTSISNVGNIFPVVLYLVAALVAFTTMTRYVDEERTSSGLLKAIGYSNKDIS
                     LKFLIYGLLASFLGTTLGIIGGTYLLSALISEILTGALTIGKTHLYSYWFYNGIAYLL
                     AMLSAVLPAYLIVKKELFLNAAQLLLPKPPSKGAKIWLEHLTFVWKALSFTHKVTIRN
                     IFRYKQRMLMTIVGVAGSVALLFAGLGIQSSLAKVVEHQFGDLTTYDILAVGSAKATA
                     TEQTDLASYLKQEPIIGYQKVSYASLTLPVKGLPDKQSISILSSSATSLSPYFNLLDS
                     QEQKKVPIPTSGVLISEKLASYYKVKPGDQLVLTDRKGQSYKVTIKQVIDMTVGHYLI
                     MSNTYFKNHFKGLEAAPAYLIKVKDKDSKHIKETASDLLTLKAIRAVSQNANHIKSVQ
                     LVVTSLNQVMTLLVFLSILLAIVILYNLTTINIAERIRELSTIKVLGFYDQEVTLYIY
                     RETISLSLVGILLGIYLGKGLHTYIMTMISTGDIQFGVKVDAYVYLVPILVILSLLAV
                     LGIWVNCHLKKVDMLEALKSID"
     gene            14539..15135
                     /locus_tag="VHC05_001075"
     CDS             14539..15135
                     /locus_tag="VHC05_001075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEQ5402392.1"
                     /translation="MENSIEAYLADSREKVTLGTVVDCFKGKAVSSKVVPGDVGLINL
                     SDMGTLGIQYHQLRTFQMDRRQLLRYLLEDGDVLIASKGTLKKVCVFHKQNRDVVASS
                     NITVLRPQKLLRGYYIKFFLDLPIGQALLDAADHGKDVINLSTKELLDIPIPVIPLVK
                     QDYLINHYLRGLTDYHRKLNRAEQEWEYIQNEIQKGLG"
     gene            15146..16102
                     /locus_tag="VHC05_001076"
     CDS             15146..16102
                     /locus_tag="VHC05_001076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HEQ5402393.1"
                     /translation="MGSVERTLKMTLATIVAILIAYQLHLDYAMSAGIIALLSVLDTR
                     KSSLVVARNRLLSFFLAFGIAMMCFSLFGFTTVGFMCYLLIIIPLLYHFQIEAGLVPI
                     TVLVTHLIAKKSIALPILSNEFMLFFVGTSVALLFNAYMGSQDQQIRYYHQKVESDLK
                     GILYRFESFLLEGKGQNEGLLIKNLDKILDEALKLVYRERHNQLFQQTNYQVHYFEMR
                     RQQNRLLGQMAINVNTLMRQSKESILLSHLFHETACQLSEQNPALTLIDDIEQLLETF
                     RHGDLPQTREEFERRAVLFQLLQDLERFILLKVEFYQDYQND"
     gene            16199..17539
                     /locus_tag="VHC05_001077"
     CDS             16199..17539
                     /locus_tag="VHC05_001077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2130 domain-containing protein"
                     /protein_id="HEQ5402394.1"
                     /translation="MNEIKCPHCHTLFTINESEYSQLLEQVRGQAFDEELQKRLINEI
                     ALLEEKAKHQLHEVVAKKEIAITSLTNQLEQIEKEQAYLRQEELAKKDQLIASLEAKL
                     DKLASQNALELANQLAEKDKEVVSLTNQLDKLALEKDATFQSKLATIEKERDGIKNQL
                     ALQAKESELSLASVRSDYEAQLKAANEQVEFYKNFKAQQSTKAIGESLELYAETEFNK
                     VRSYAFPNASFVKDNQLSSRGSKGDYIYREVDTNGVEILSIMFEMKNEADTTKTKHKN
                     SDFFKELDKDRREKDCEYAVLVSMLEADNDYYNTGIVDVSHEYQKMYVVRPQLFIQLI
                     GILRNAALNSLHYKQELALIKEQNIDITHFEEDLDQFKNAFAKNYQSASNNFKKAIDE
                     IDKSIKRMEEVKRFLTTSENQLRLANNKLEDVSVKKLTRQNPTMREKFEALKDQ"
     gene            17655..18539
                     /gene="truB"
                     /locus_tag="VHC05_001078"
     CDS             17655..18539
                     /gene="truB"
                     /locus_tag="VHC05_001078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="HEQ5402395.1"
                     /translation="MINGIINLKKEAGMTSHDAVFKLRKLLQEKKIGHGGTLDPDVVG
                     VLPIAVGKATRVIEYMTEAGKVYEGQVTLGYSTTTEDASGEVVARSSLPAVLTEELVD
                     QTMTTFLGKITQTPPMYSAVKVNGRKLYEYARAGESVERPRREVTISLFERTSPLNFT
                     EDGLCRFSFKVACSKGTYVRTLAVDLGRALGVESHMSFLQRSASAGLTLETAYTLGEI
                     ADMVSKQEMSFLLPIEYGVADLPKMVIDDTELTEISFGRRLSLPSQEPLLAAFHGEKV
                     IAILEKRDQEYKPKKVLI"
     gene            18568..19500
                     /locus_tag="VHC05_001079"
     CDS             18568..19500
                     /locus_tag="VHC05_001079"
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="HEQ5402396.1"
                     /translation="MEIEYIKDYRDINQEDDTVLILGYFDGLHRGHKALFDKAREVAN
                     KEGLKVVVFTFTESPKLAFSRFSPELLLHITYPKKRYEKFADYGVNKLYLVDFTSKFS
                     KVSSDHFITHYIKNLKAKHIVVGFDYKFGHNRTDSDYLTRNFEGQVYTIEEIKEDHRK
                     ISATWIRKLIQEGNVVKANHLLGYDLSTRGRVVHGDARGRTIGFPTANLAPIDNTYLP
                     ADGVYVTNVIVANKIYRSMTSLGKNVTFGGKELRLEVNIFDFDEEIYGEIIEIVWLDK
                     VRDMEKFEGIEDLTDRLEYDKRTALNWKKDSKLS"
     gene            19543..19947
                     /locus_tag="VHC05_001080"
     CDS             19543..19947
                     /locus_tag="VHC05_001080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922362.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Spx/MgsR family RNA polymerase-binding
                     regulatory protein"
                     /protein_id="HEQ5402397.1"
                     /translation="MVTLFLSPSCTSCRKARAWLVKHEVDFQEHNIITSPLSRDELMS
                     ILSFTENGTEDIISTRSKVFQKLDIDVEELSISDLIDLIAKNPSLLRRPIIMDQKRMQ
                     IGFNEDEIRAFLSRDYRKQELRQATIKAEIEG"
     gene            19949..20227
                     /locus_tag="VHC05_001081"
     CDS             19949..20227
                     /locus_tag="VHC05_001081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UPF0223 family protein"
                     /protein_id="HEQ5402398.1"
                     /translation="MSGNYYYPLDLSWSTEEISSVLHFLNKVELAYEKKVDAKQLLDS
                     YKTYKTIVKSKAQEKQIDRDFQKVSGYSTYQVVKKAKAIEKGFFSLGN"
     gene            20217..21005
                     /locus_tag="VHC05_001082"
     CDS             20217..21005
                     /locus_tag="VHC05_001082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="inositol monophosphatase family protein"
                     /protein_id="HEQ5402399.1"
                     /translation="METKYAFARQIIKEAGLFIKSKMSEQLDIQVKTQFDDLVTNVDQ
                     ETQQLLMDRIHQTYPCDAILAEENDVRHPINQGNVWVIDPIDGTVNFIVQGSQFAVMI
                     AYYEQGIGQFGLIYDVMADQLLAGGGDFEVTLNGDKLPAYQEKPLERSLIGCNAGMFA
                     RNDRNLAHLIAKTLGVRVYGGAGICMVKVMKQELLAYFSFIQPWDYAAAKVLGDKLGY
                     VLLTIDGYEPDFQTRQKIMFVPKCQLTRIASFLTKDSAVTLEDQ"
     gene            21008..22318
                     /locus_tag="VHC05_001083"
     CDS             21008..22318
                     /locus_tag="VHC05_001083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RsmF rRNA methyltransferase first C-terminal
                     domain-containing protein"
                     /protein_id="HEQ5402400.1"
                     /translation="MMSLPKEFINTYQAILGKELEDFLASFNQEPVNAFRINPLKNQL
                     KTFEHPIPNTLWGYYGKLSGKSPEHVSGLVYSQEPAAQMVAQVAAPQKGSRVLDLAAA
                     PGGKSTHLLAYLDNTGLLVSNEISKKRSKVLVENIERFGARNVVVTNESADRLAKVFS
                     HYFDTIVFDGPCSGEGMFRKDPDAIQYWHHGYPAECAKLQKSILEDALVMLKSGGELI
                     YSTCTWAPEENEDVVQWLLETYTFLELVDVPKLNGMVSGIGLPETARMYPHRYQGEGQ
                     FVAKLKDKRQEGQSTKLKAPKSNLTKDQLRLWKMFEKDHLNLTLSGTLQTFGDYLYLL
                     PDGLPALDGLKIARNGLELGVFKKKRFEPSYALGLALKSDEVRSSIELREEDFRPYVS
                     GNVITLPQSYPTGWYQLLINGNGLGFAKVVDKTIKNNFPKGLRF"
     gene            22457..23323
                     /locus_tag="VHC05_001084"
     CDS             22457..23323
                     /locus_tag="VHC05_001084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter substrate-binding
                     protein PstS family protein"
                     /protein_id="HEQ5402401.1"
                     /translation="MKMKKKFFLLSLLALSTFFLSACSSWIDKGESITAVGSTALQPL
                     VEAVADEFGSSNLGKTVNVQGGGSGTGLSQVQSGAVQIGNSDVFAEEKDGIDASKLVD
                     HQVAVAGLAVIANPKVKVSNLSSQQLQKIFSGEYTNWKQVGGEDLAISVINRAASSGS
                     RATFDSVIMKGVNAKQSQEQDSNGMVKSIVSQTPGAISYLSFAYVDSSVKSLQLNGFK
                     ANAKNVATNDWPIWSYEHMYTKDKPTGLTKEFLDYMFSDEVQQNIVTHMGYISINDME
                     VVKSHDGKVTKR"
     gene            23334..24269
                     /gene="pstC"
                     /locus_tag="VHC05_001085"
     CDS             23334..24269
                     /gene="pstC"
                     /locus_tag="VHC05_001085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019323233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HEQ5402402.1"
                     /translation="MENQELAKKLASPSKNSRLETFGRTITFLCLALIVFIVAMILIF
                     VAQKGLSTFFVDKVNLFDFLFGKEWQPSVKNAAGIPYLGALPMITGSFLVTILSAIIA
                     TPFAIGAAVFMTEISPKYGAKLLQPAVELLVGIPSVVYGFIGLQVIVPFMRSIFGGTG
                     FGILSGVCVLFVMILPTVTFMTTDSLRAVPRHYREASMAMGATRWQTIWRVVLNAARP
                     GIFTAIIFGMARAFGEALAIQMVVGNSAVMPSSLTTPAATLTSVLTMGIGNTVMGTVQ
                     NNVLWSLALVLLLMSLAFNSLVKLITKERKRNYER"
     gene            24259..25146
                     /gene="pstA"
                     /locus_tag="VHC05_001086"
     CDS             24259..25146
                     /gene="pstA"
                     /locus_tag="VHC05_001086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008088954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HEQ5402403.1"
                     /translation="MNAKKVDKVATGTLYTIAGIIVAILASLILYILVRGLPHISWSF
                     LTGKSSSYEAGGGIGIQLYNSFFLLIVTLIISIPLSTGAGIYLAEYAKKGPVTNFIRT
                     CIEILSSLPSVVVGLFGYLIFVVQFEYGFSIISGALALTVFNLPQMTRNVEDSLLHVH
                     HTQREAGLALGLSRWETVFYVVIPEALPGMVTGIVLASGRIFGEAAALIYTAGQSAPA
                     LDWSNWNPLSVTSPISIFRQSETLAVHIWKVNSEGTIPDATLVSAGSAAVLLIFILIF
                     NFSARFIGKKLHSKMTAAK"
     gene            25162..25965
                     /gene="pstB"
                     /locus_tag="VHC05_001087"
     CDS             25162..25965
                     /gene="pstB"
                     /locus_tag="VHC05_001087"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402404.1"
                     /translation="MTEYNWNERHIITFPEETLALATKDLHVYYGAKEAIKGIDMQFE
                     KHKITALIGPSGCGKSTYLRSLNRMNDTIDIARVTGEILYQGIDVNRKDMNVYEIRKH
                     LGMVFQRPNPFAKSIYKNITFAHERAGVKDKKVLDEIVETSLKQAALWDQVKDDLHKS
                     AFTLSGGQQQRLCIARAISVKPDILLMDEPASALDPIATMQLEETMFELKKNYTIIIV
                     THNMQQAARASDYTAFFYLGNLIEYDKTRNIFQNAQCQSTNDYVSGHFG"
     gene            25978..26736
                     /gene="pstB"
                     /locus_tag="VHC05_001088"
     CDS             25978..26736
                     /gene="pstB"
                     /locus_tag="VHC05_001088"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402405.1"
                     /translation="MTEPILQIRDLSVYYNQKKTLKDVSLDLYPNEITALIGPSGSGK
                     STLLRSINRMNDLNPEVTITGSIVYNGHNIYSPRTDTVDLRKEIGMVFQQPNPFPMSI
                     YENVVYGLRLKGIRDKSILDHAVESSLKGASIWNEVKDRLHDSAVGLSGGQQQRVCIA
                     RVLATSPRIILLDEPTSALDPISAGKIEETLLLLKKDYTLAIVTRSMQQASRLSDRTG
                     FFLEGDLLECGPTKAMFMNPKRKETEDYISGKFG"
     gene            26804..27457
                     /gene="phoU"
                     /locus_tag="VHC05_001089"
     CDS             26804..27457
                     /gene="phoU"
                     /locus_tag="VHC05_001089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002294804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HEQ5402406.1"
                     /translation="MLRTKFEEELDKLHNQFYSMGTEVLAQINKTVRAFVSHDRELAK
                     EVIEEDDTINNFETKLEKKSLEIIALQQPVSNDLRMVITVLKASSDIERMGDHAASIA
                     KATIRMKGEERIPVVEEQINLMGKAVKQMVEEALNAYINADDTKAYEIAASDEIIDQY
                     FRNIQTLAVEEIRKSPDAVFAGKEYFQVLMYLERIGDYARNICEWIVYLKTGKIIEL"
     gene            27662..30199
                     /locus_tag="VHC05_001090"
     CDS             27662..30199
                     /locus_tag="VHC05_001090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M1 family metallopeptidase"
                     /protein_id="HEQ5402407.1"
                     /translation="MKTVEHLIETFVPENYNIFLDINRQTKTFTGNVAINGEALDNHV
                     AFHQKDLDIKSILLDNEAVIYQVDNDNEVVRVELPETGMMTLVIEFSGSITDNMTGIY
                     PSYYTKNGEKKEVISTQFESHFAREAFPCIDEPQAKATFDLSLTFDQEIGEIALSNMP
                     EVNIDRREETGLWTFDTTPRMSSYLLAFALGELHGKTVESKKGTTVGVYATTAHPLSS
                     LDFSLDIAVRVINFYEDYFGVHYPIPQSLNIALPDFSSGAMENWGLITYREIYLLVDE
                     NSTVQSRQQVALVIAHEIAHQWFGNLVTMKWWDDLWLNESFANMMEYVSIEAIEPSWK
                     IIEDFQTGGIPLALKRDATDGVQSVHVEVNHPDEINTLFDPAIVYAKGSRLMHMLRRF
                     IGDRDFAIGLHHYFEKYQYRNTVGRDLWNILSDTSGKDVAAFMDAWLEQPGYPVLTAR
                     LENDQLILSQKQFFIGKGEEKGRLWPIPLNTNWHGLPETLTEAEMVIPNFSQLAAENE
                     GALRFNIDNTAHYITDYQGSLLDALVTELAQLDNTSALQVIQERRLLADSGLISYAEL
                     VDLIAQLDDSKSYMVAEAVQQVVSGLKRFIDEGSLAEKSFNRLVTTIYQEDFNQHGFE
                     KKADESDEDEMVRQVALGRLWLAENQTIIDGLRTIFEAYQNNIASIPAAVRRLVLANQ
                     MKYFETDSLVDIYFETYVATTDNNLRSDLTVAFSQTKQPTTIRRILVSLKDKDIIKPQ
                     DLSYWYNALLGQSFTQDIIWEWARENWDWIKSALGGDMSFDKFVIYPASNFKTPKHLA
                     EYKSFFEPKLDDMAISRNITMGINEIEARVALITKEKEAVIAALSHY"
     gene            30546..>31213
                     /locus_tag="VHC05_001091"
     CDS             30546..>31213
                     /locus_tag="VHC05_001091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5402408.1"
                     /translation="MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGI
                     YDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTAKEGLDDKGHGFELGADDYLTKP
                     FYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
                     LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGY
                     ILKN"
BASE COUNT        10037 a         5313 c         6368 g         9495 t
ORIGIN      
        1 agcgcttata aattaattta acttcactta actatttaaa taggtttatt atattcagga
       61 ggaataatat gaaacccaaa caccttctct gtctttcaac agttgttgct ggattagctt
      121 tattttcaac tatgacgcac tcagttttag ctgatgatgc ttcaaatccc gatactattt
      181 taatgaataa caaccaagcg aatcttcaaa gagatgctct agtgcaaaag cttgatgagg
      241 gacatcaaca attagaagct attaaacatg aagctaaagg tactgatatt gaggctactg
      301 ttaacaaagc tatcgatgct gttgatcaca tgaagagttc tatacgcttc aatactgaaa
      361 cgatctatga ttttagttca attggggcaa gagtagaagc attatcagat gctatcaaag
      421 caatcgtatt ttccacaacc caattaactc acaaagtaga aaaagcgcat actgatatgg
      481 ggtttgctat tactaaatta gtcattcgta ttatagatcc atttgcatct gttgacgcta
      541 tcaaagctca agtacaagaa attaaagcac ttgaggaaaa agttatcaat tatcctaatt
      601 tacagccaac agaccgtgct actatctata ctaaagctaa actaaataaa gctatttgga
      661 acactcgttt agaaagagat aaaaaggttt tagggatcaa atcatttgac gtttataata
      721 gacttaacaa agctatcaca catgcggttg gtgtccaact aaatccgaca accactgttc
      781 aacaagttga cgatgaagtt attgctgtgc aaaatgcttt ggaaacagct cttaagtcat
      841 agagtgtata agtaatgtgt tgtataggta gatgattata ttaggatata gaataggtaa
      901 agattttaaa tatcttacca ttgtagagtt tgaggtgatg ctctcataaa caatgagtca
      961 cctgtagccc tttttgcctt taacatgatg taccaattta aggtattgtt caaccgtcac
     1021 tattgaatct tgtttaacct cctaaactaa taagattcaa tatgaaaacg tgtattctta
     1081 aaaaaatccc tatgatctgt ttaaaaacaa attgtaggga tttttttaac tatttaactt
     1141 attattttgg gactaggaat cgctttagga atatcatgaa gtatagttat gttataagat
     1201 aagtaatatt tttacatttt tacaatacga tagtgtgtgt gatgtaattg tctcttagcg
     1261 ataggggtaa tttggtggaa gagtaaggac caagattcat gacgcctcca aatactggta
     1321 tgttgattgc catttaattg gtaagttacc aacatcgttt tttgactaat ggattcaatc
     1381 tgaaaatggt tgaagttact tggataataa atttcttggt tcaaaaattg ttcatagtta
     1441 actgtttggc cattcgcatc aaccagttgg aaagacttag caatgtagtg gtcatagtca
     1501 ggaaccttac tcaaaattaa tttttcgtag cggtagagct ttttggcgac attatcaaaa
     1561 atctcttctt cgagaatcat ggcaggttca acgtgaatat caatgtcata aatagaaaat
     1621 tggtcactca ataactgctc cactttctct gtaatagagt gactttcata gactgaaaga
     1681 tcaggattca tttcaagtac aatatcaaga tagacattgc taccataggt cctagctcgt
     1741 tgagacttaa cggcgacaat tttagggatt tctaaaatga ctttttcgta ttttttcaaa
     1801 tgacggctat caaatccatc agataaacta aacgaacttt ccataaagat atcaaaagct
     1861 gttttaagaa taaagaacgt aatgatcata gcagctatat gatcgataac tggtaaatgc
     1921 aaagaagctg ctataatagc aattgatgtt ccgatagaag taacagcatc agctagatta
     1981 tccttagaag cagcgactaa ggcactggat tttacacgtt tggaaagacg tttgttaaag
     2041 acatagaccc ctaacataac aaaagctgaa acgataccga caatagcccc aagagggtca
     2101 atatcaactt gctgaccact aaagatactt ttaattgtgt gaatcagtac ttggaaacct
     2161 acaagaaaca taataaaaga agtgacaagg ctggataaat cttcaatttt ccaatgacca
     2221 aatttatgat tggcatcggc tggttggcta gctaagtgaa gaccaataag cagggctaca
     2281 tttcccacaa tatccgataa attgttaaat ccatcagcaa taagggaact tgcatttaac
     2341 aaataaccag ctaataattt ggcagcacta agcaacaagt agacaataat actaacgatt
     2401 gggccctttc tggctagttt taaatttgca atcggatcct gtgtcataat aactcctttg
     2461 atttcaactt tatattatac cataaaaagg ggcttaagaa aaaagcctag cttcttgaac
     2521 ttggcagaag aagactaggt ataactgggt agtactaacg taatgtttac ttaataaagt
     2581 aatgcttggt ttctaaaata acaactggcg agagagctag gagggcaatc aggttaggaa
     2641 gtgccattaa accattgaca atatcagcca aaacccaaat cagttctaac ttaaggaagc
     2701 ctcctagacc taccattaag acaaagacaa tacggaagta ggtgagatgt gtaatgccaa
     2761 agaggaattc aaagcagcgt tctccataat aactccatcc taaaatcgtt gtaaaggcga
     2821 agagaactag ggaaaaggtt aggccaaaag tccctaaatt tccaaacaca gtggcaaagg
     2881 cagattgggt cagaggagcc ccttcgagct gtccagtcca ttggcctgtt actaaaatag
     2941 ataggccggt tagggtacag ataataatcg tatcaataaa agttcctgtc atggagatca
     3001 ggccctgctc cacgggttca ttggttttag ccgctgctgc agcaataggt gcagatccta
     3061 gtccagactc attggagaag acaccgcgtg caattccttt ttgaatggta tccttcatga
     3121 gacttccagc aaagcctcca atagcagctg tcggagtgaa ggctgattga aagactaaac
     3181 gaataacagg aagtagctgc tggtagtgac taaaaataac tgctaaacta gatagaatat
     3241 aaaaaatagc cataaaagga acgacttttt cagccacttt ggaaatggaa tgaatgccac
     3301 caaaaataat ggcagccaca aagatagcta aaacaatact gaccatttgt ggggataagc
     3361 caaagctatg acctaaagac gaggtgatcg agttcacttg agcaaaggtt ccgattccaa
     3421 atagggcaac taggatccct gaacccgcaa aaagaatggc taagggtttc cattttgtcc
     3481 ccatgccatt aacaatatag tacataggac caccagaaat atgaccgctg gcatcctttg
     3541 tacggtattt aatcgctagt accccttcag cgtacttagt ggccattcca aaaaaagcgg
     3601 caacccacat ccaaaagagc gctccaggac caccagactt gatagcagtg gcaactccaa
     3661 caatgttacc agttccgaca gtagcggcaa gggcagttgc aagagcagca aaggatgaaa
     3721 tatctccatg tccttcgtca tctgaaaaaa tgagtttaaa ggctcttggc agttttaaga
     3781 tttgaattaa tcctaaacga ctggtaaggt aaatccccgt cccaaccaac aaaattaaga
     3841 ggggcggtcc ccaaacaagg ttatcaatta atttaacgag tgctatcatc tttctctcct
     3901 aaaagtcatc gaagacgcca aaagaaaaaa gctatctctt tctttgagac aacttctgaa
     3961 gcaatgataa aacagcaaac acaaaaaaga ctaagactgt tcttaatggt gtttgtattt
     4021 taccttctgt ccttttgcct gagagattga gcagtatgcc ttgccccttc ggcgcctaat
     4081 aaggtctctc cagaagtccg tccatcaaac agtcccgttc aaaaactgaa cacctgagag
     4141 tataactcct tcggcgaaaa taaattcttc tcctgcatga catcattcgg tttattaaat
     4201 tagaactatc ataccttaaa aaacgaatga agtcaaccaa aatagcaaaa aaataaggaa
     4261 tgctttaaga aatcgctatt atttttaaat atctgaacct aaactagaaa aaaggaatct
     4321 ctttactttt ggggtcttct ttgctatttt ccttggaaac atgatataat tttaaggttg
     4381 ataaaagaga tgtcactgaa cgagattaag gagaaagcat gaatccttta ttaaatggaa
     4441 tgaatgatcg gcaggcacaa gctgttcaaa caactgaagg ccccttattg attatggcgg
     4501 gggctggttc tggtaaaaca agggtactga cccatcgtat tgcctattta attgatgaaa
     4561 aatttgtcaa tccttggaat attttagcta ttacctttac taataaggct gcgcgtgaaa
     4621 tgaaagaaag agccttgtcc ttaaatccag ctactaaaga taccttaatt gctacctttc
     4681 actccatgtg tgtacggatt ctgcgtcgtg aggctgatca cattggttac aaccgaaact
     4741 tcacaatcgt ggatccaggt gagcaacgaa cgttgatgaa gcgcatttta aaacaattaa
     4801 atatagaccc taaaaagtgg aatgaacgtt ctattttagg aactatttca aacgctaaaa
     4861 atgatttgct tgatgaaaag ggatacgagg cacaggctgc tgatatgtat agtcaaatcg
     4921 tagcgaggtg ttacaaagct tatcaggaag aattacgacg tagcgaagca cttgactttg
     4981 atgatttaat catgatgacg ctacgcctgt ttgacgctaa tcctgacgtg ttagcttatt
     5041 accagcagcg ttaccaatac attcatgtgg atgagtacca agataccaac catgctcaat
     5101 atcagctaat taaattgcta gcttctcgct ttaaaaatat ttgcgttgtt ggagacgctg
     5161 atcagtctat ctatggttgg cggggagctg acatgcaaaa tattcttgat tttgaaaaag
     5221 attacccaga tgctaaggta gtgcttttag aagaaaacta tcgctctacc aagaaaattc
     5281 tgcaagcagc taacgacgtg attaacaata accgtaatcg ccgtcctaag aaactttgga
     5341 cacaaaatgc ggatggggaa caactggttt attacagggc aaatgatgag cgagatgagg
     5401 cagtatttgt ggcctcaacc attagcaata tgagtcaaga gcttggaaaa aacttcaaag
     5461 atttcgctgt tttataccgt accaatgccc aatctcggac cattgaagaa gcactcttaa
     5521 aatccaatat tccttacacc atggttggag gcaccaagtt ttacagccgt aaagaaattc
     5581 gggatttgat tgcctattta accattgttg ctaaccctgc tgataatatt tcttttgagc
     5641 ggattgtgaa tgagcctaaa cgaggtgttg gtccaggaac gcttgataaa ctgcgtcagt
     5701 ttgcctatga gagtgaccag tctttattag aagcagcttc aaatctattg atgtccccct
     5761 tgaaaggtaa agcagcacaa gctatcatgg acttggccaa tattctcggt cagctacgtc
     5821 aagacctaga tcagatgagt atcaccgact tagcagaagc tttgttagaa aaaacaggct
     5881 atttagatag cttacgcctg caaaatacat tggaaagcca agcccgtatc gaaaatatcg
     5941 aagaattctt atctgttacc aaaaattttg acgagtcaag tgcctctcaa gaagaagacg
     6001 aaaccggtgt tgatcgcttg ggacgttttt taaacgattt agcactgatt gctgatacag
     6061 atgattccca agcagaagct gctgaagtaa ccttaatgac cctacatgct gccaaaggct
     6121 tggagttccc tgttgttttc ttaattggta tggaagaagg tgtcttcccc ttatcacgtg
     6181 cctctgaaga tccagatgaa ttggaagaag aaagacgttt agcttatgtc ggaatcacaa
     6241 gagctgaaga agttctcttt atgaccaatg ccaacaccag aaccctcttt ggtaaaagta
     6301 gttataaccg tccaacacgc ttcttgaaag aaatttcaga ggaactactc tcttataaag
     6361 gattggcaag accagcacaa tcttcatttg gtgtgcgttt ttctactgaa acacacacac
     6421 agtttggaca agggatgagc ctatcagaag ccttacaagc tcgaaagacc caggctcaag
     6481 taagacaatc agcacagcca atgcaggcac atacgatacc atcagcttca actagctcag
     6541 ttttaccgtt tggttctaat agctctgtag aagaggtcac ttggcagatt ggcgatatcg
     6601 ctcaccataa aaaatgggga gacgggactg tgcttgaggt ttcaggctcc ggaaaaacga
     6661 tggaattgaa aatcaaattt ccagaagttg gtttaaagaa attactagca agtgttgctc
     6721 ctattgagaa aaaataagaa aaaaatgagc ttcctactat ataagtgagt aggaagctca
     6781 ttttttttag atttctgtat catataaaag ttaaaaaatt ttaagtttta ggagcatatc
     6841 agttgcattt taaatttaaa ggtgtataat aacaatataa attaaataac gagtggtcac
     6901 tttataaaat attatcaaaa taacatttta taggattttg aaatatcggt attcaaacaa
     6961 aaaataaact aacactttat tatttagttt atatagtcac tttttgaaag tcgactatta
     7021 aaagactatt gcttgaagaa taacagctgt tattcttcct tggacaaaag gtacaggagt
     7081 atctaaaaag gagaattatc atgggactta tttggacttt aatcgtcggt gcgcttattg
     7141 gtgtgattgc tggagcactt actaaaaaag gtggttcaat gggctggatt gcaaacatcg
     7201 ctgctggtct agttggttct tccgttggtc aagctttact tggttcatgg ggcccttctt
     7261 tagcaggaat gtctttgatc ccgtcagtta ttggtgccgt tatcgttgtt atgatcactt
     7321 cttttgtact aaacaaaact aacaactagt ttcctcttta tttagtaagt acttacaaat
     7381 agagaatgtt aagtagaaaa gaggtctgta tgtcaaaatt gttaaagatt agttattgtc
     7441 ttgtcggact tgttctattg tctgtttttg gatgggtagt tggaataacc ggaggctata
     7501 tatatttacc ttatagttat cgttggctaa gttggggtat ggatagtttt cccaatctct
     7561 tagattcagc tttatcctat tattacttct ggacagccct tgtattattt gttataacat
     7621 ttcttgcctt attagttatt attttatacc caagaattta tactgaggtc cagttacgcc
     7681 ataaaaataa aaaaggaaca cttttattaa aaaaatcggc tattgaaagt tatgttgcga
     7741 ccgctattca aactgcaggt ttgatgccaa acccaacagt cacagctaaa ttatataagc
     7801 ggaagtttaa gattatcgtt aaaggacgtt tagcttctcg tgtagcagtg gcagatcaaa
     7861 ttagtggcgt gaaagaaggg atcgaaaaag gtttaactga gttcttcgga attaattatc
     7921 ctgttaattt caaagtttat gttaaagata ttgctgattc tgatcgtaaa catattacca
     7981 gaaatcgtgt agaataggag atctatcatg gaattttatg aaaaattcaa gtaccctatt
     8041 attggtggct tggtggggct aattattgcc atattgctca tggcttttgg tttattcaaa
     8101 acgctactag caattatttt cattatttta ggaatatatg gtggcctgta tgccaaaaaa
     8161 acaggtatta ttgatcaatt tcttaatcgc aaataaagga gatttattat gactgaaact
     8221 tatattaaaa acacatctaa agacttaact tcagcaattc gtggtcaatt aacatatgat
     8281 gataaagtaa ttgaaaaaat tgttggttta gcacttgaaa atgttgatgg gttactgggt
     8341 gtaaatggtg gtttttttgc taacctaaaa gataaattag taaacaccga atctgtacgt
     8401 gatggcgtga acgtggaagt tggaaaaaaa caagttgccg ttgaccttga tattgtcgct
     8461 gaatatcaaa agcatgtgcc gactatttat gactctatta aatcgatcgt tgaagaagaa
     8521 gtgaagagaa tgaccgatct ggatgtgatt gaagttaatg ttaaagtagt cgacattaaa
     8581 acaaaagaac aatttgaagc tgaaaaagta agtttacaag acaaagtttc agacatggca
     8641 cgttcaacat ctgaatttac gagtcatcaa gttgagaatg ttaaagcttc agtggataac
     8701 ggtgttgaaa agcttcaaga tcaaaaagct gagccacgtg taaaataatc atatgtcgtc
     8761 aattaggtaa gctaaaggag ggtttattgt gtcagatgaa aaatataatg cgaaattaga
     8821 tcaagctggt ggcaagttaa aagaaggatt tggtaagatt tctggagata aatctttaga
     8881 aactgaaggt aaagtagata aagttactgg aaaagttaaa gaggttattg cagacgccaa
     8941 agatactgta aaaggattag ctaaaggctt agataataaa gataaataaa ggggacatga
     9001 tggaaaaaac tcaaattaaa agcactctta cttatgacga taaggtcatc gaaaaaattg
     9061 tcggtcatgc tttggaaaac gttggcggat tactagctgt aacaggtgga tttttctcaa
     9121 atatcaaaaa taatttggtg aattctgagt ctgtaactga tggtgtttca gttgaagttg
     9181 gcagcaagga agtagcagtt gatttagcaa tcattgtaga atacggtaaa gatattcctg
     9241 ctattgcaga atctattaaa gctattgttt ctcaaaacgt tgatagtatg acacatttga
     9301 aagttgttga agtcaatgtg aacgttgttg atattcgtac taaggaagaa catgaagctg
     9361 ctagcgttac tgttcaagat cgtgtcacta gtgcagcttc aagtacttca caatttgtat
     9421 cagaacaaac agaaaaatta aaagatacta tctctgatac tgtaaatagt gatgaggcag
     9481 ctaaataagc aatcgtctag gaagtattat tgactagtgg tgataagttt gagctggtat
     9541 ttaccagctc tttttgtcac ggttaaaaag atacggacta ttgtcatctc tctaaaaata
     9601 tgatttaatt agatagaaat ttttcaaatt gttagaaagg agtaaattaa gtgataagtc
     9661 ctaaaaaaga gataacaagt tcaaaatatc aaaaaattgc tatttcagta gctcagcgta
     9721 tcgcaaatgg cgaatatgaa gtgggcgaaa agttaaagtc aagaactact atcgcctcga
     9781 catttaatgt atcacccgaa acggctcgta aaggcctgaa tattttagct gacttgaaaa
     9841 ttttgacttt aaaacatggt agtggagcta ttgtgctgtc aaaagaaaga gctattgagt
     9901 ttataaatca atacgaatca acccattcca tcgctgtttt aaaagaaaaa atacgtgaga
     9961 ctattaatga tcagggaaaa gcaatggaaa aaatggctgt tttggtcaat gattttttaa
    10021 tgcaaagtca atctgttagt aagcaatacc cattagcacc ttatgagatt atttgtagtc
    10081 aagattcgga acattttggc aaatctattg gtgtgttaaa tatctggcac cagacaggag
    10141 caactatcgt cgctattgaa catgctggtc agtttatcgt ttccccaggt ccttattctg
    10201 ttattgaaaa aggcgatcat atttatttcg ttggtgatga gtcagtcatt tcacgaatga
    10261 agaccttttt taatttacga aaaggattat aagtttgagg gcccacctca aacttttttt
    10321 gttgctgttt agcattatta aaagaggcag atcatcatgg tttgtctttc caaaatatct
    10381 gtttagacag ttgttttgga ttgggagcat gatttcagac tcttttgatg ttttttaatt
    10441 gtctagagta actgctttga gaataatatc ggcaacctct tcagtggttt cttgatagcc
    10501 attagcaatc caatagctga taatgctctc aatactggca aggtagactt ctaaagcata
    10561 gggataagga atatggtatt gattggtcac aatgtcttgg aaaccagtaa tagtagtcaa
    10621 aaattggtaa cagaaatcct tgatgagttg cggaaatttg aggtaagaaa tagtagcgag
    10681 tgcggttata aattctctat gttctataag gtaggacaag gtttgattga ggacttgtcg
    10741 agtgtctgtg tagatttcag cctggtttaa caaacggtac aaatcatcca gagtgtcatt
    10801 tttgaagtga ttcatcatgt caaatttatc agtgtagtgg aggtagaagg ttcctctatt
    10861 gataccagcc tttttagtaa ggtcagagac agtaagagtt tcaaaagatt gttcagttag
    10921 taaggtggtt aaggcggtct ttacataagc tttggtttca gtatgtcttt tggtcattct
    10981 caggtgctcc ttaaatcaac agttgcgtca gatttgttct tgttaaatac ttagggccat
    11041 tatataataa ggttataatt aaatcaacac tatgttcaaa taatggaggg gcagatggct
    11101 tttattgaat taaaacaggt ttcaaaatct tatcaggtag gagagacgac tgtttttgcc
    11161 aaccacgaag tgtcttttga gattaataaa ggagaactag tggttatttt gggagcatcc
    11221 ggagctggta aatcgacagt cctcaatatt ttggggggca tggacacagt agatgcaggt
    11281 caagtaatta ttgatggcaa agacattgct cattacacgt ctaaggcctt aactcagtat
    11341 cgtcggaatg ctattggttt cgtttttcaa ttttataatt tggttcctaa tttgacagct
    11401 aaagaaaatg ttgaattagc agttgaaatt gtagcagatg ctttagatcc tgtgaccatt
    11461 ttaaaggaag taggactcag tcatcgtctg gatcattttc ctgctcagct ctcaggtggt
    11521 gaacagcaac gggtttcgat agcacgtgcc ttagctaaaa accctaaatt gcttctttgt
    11581 gatgaaccta caggtgccct tgactaccaa acaggaaagc aaattctaac cctcttacag
    11641 gatatggcac gaactaaggg gaccacggta gttattgtaa cccacaatgc tgctattgct
    11701 ccgatagctg atcgtgtcat ttttatgcat gatgcacagg ttaccaagac agtcattaat
    11761 aaggaacctg caagcattga gacaattgat tattaagagg aaggtgtcgt atgataaaga
    11821 aaaccttatg gaaggatatt ttgagagcta tcaagaatag taaagggcga ttcatttcct
    11881 tatttttcct aatggcctta ggctcctttg ctttagttgg acttaaagtc accggtccag
    11941 atatggaacg aacagccagc cgttacctcg aaagacacca ggtgatggac ctaacggtac
    12001 tggcttctca tcaattttcc caagccgata aacaagagtt agatacgtta aaaggggctc
    12061 atttagaata tggtcattta cttgatgtca gtctaactag caaccagaaa tctcttaggc
    12121 tctatagcgt gccaaagaaa gtgtctaagc cagtcttggt taaagggagt tggccaaagc
    12181 gagagacaga tttggtttta tcctcctcac ttgctaaaaa ctatcagatt ggagatgaac
    12241 tagtagtcac ctcacctatg gaaggtttgc tgacgacaac ccattttcaa gtggttggtt
    12301 ttgcgaattc ttcagaagtt tggtccaagt ccaatttagg aagttcctca accggagatg
    12361 gaagtctcta cgcttatgct tttgttaatc caaacgtttt taaaagtgcc tttaacctgc
    12421 tgcgcatccg ttttagtaat cttcgtctga caaacgcttt ttccaaagac tatcaaaaaa
    12481 gggtaaccca aaaccaagct catttggata atctacttaa agataatggc cagaagcgtt
    12541 atgatgacct ccaaaatcag tatgaccttg ccttaaaaaa tggcagagca gcacttgcaa
    12601 aggaaacagt gaaactagct gcgagtgagg agaacttaac ttttttagaa ggctctgctt
    12661 tacaagaagc taagcatcag attgaacaag gcaaacaagc attagccaag gaggaaaagc
    12721 agttagagca ggtgcaggct acaaaagata agctagaaaa acccagttac ctgacttata
    12781 atcgctcgac cctaccagga ggagaaggat atcatactta tgcaacttca acgacctcca
    12841 tttcaaatgt tggaaatatt tttcctgttg ttctttatct cgtagctgct ctagtagcct
    12901 ttaccaccat gacacgttat gttgatgaag aaagaacaag ctctggtcta ttaaaagcca
    12961 tcggttattc taacaaggat atcagtttaa agtttcttat ctatgggctt ttagccagtt
    13021 ttttagggac aactttaggt attattgggg gaacttacct cttatctgcc ttgatttcag
    13081 agatcttaac aggagctttg actattggaa agactcacct ttatagttat tggttttata
    13141 atggcatagc ttacttgctg gctatgttat ctgctgtttt accagcctac ttaattgtca
    13201 aaaaggaatt attcctcaat gcagctcagt tattgctgcc caaacctcct agtaaggggg
    13261 caaaaatctg gttggaacac cttacttttg tctggaaagc tctgtccttt actcacaagg
    13321 tgaccatacg taatattttt cgctataaac aaagaatgct gatgaccatt gtaggcgttg
    13381 caggctcagt agccctttta tttgcaggct tagggattca gtcgtcatta gccaaagtag
    13441 ttgagcatca atttggtgat ttaacgactt atgatatttt ggctgtcggt tcggccaaag
    13501 cgacagcgac agagcaaact gacttagcta gctatcttaa acaagaacct attatagggt
    13561 accaaaaggt atcttatgcc agcttaaccc ttcctgtaaa gggattacct gataagcaaa
    13621 gtatttccat tttatcaagt tcagctactt ctcttagccc ctattttaat ctgctggata
    13681 gtcaggagca aaagaaggtt cccattccaa cctctggtgt tttgatttct gagaaattag
    13741 cctcctatta caaggtaaaa ccaggtgatc agttggtatt gactgatcgg aaaggacagt
    13801 cttataaagt gacgattaaa caggttattg acatgacagt tggccattac ctgataatgt
    13861 ctaataccta ttttaagaat cattttaaag gattggaggc tgctcctgcc tatctgatta
    13921 aggtaaaaga caaagatagc aagcacataa aggagacagc cagtgacttg ttaaccttaa
    13981 aagcgattag agcagtttca caaaacgcca atcatattaa atctgttcag ctagtagtca
    14041 cctctcttaa tcaggtcatg accctccttg tcttcttgtc tattttatta gcaatcgtta
    14101 tcctttataa cttaacgact attaatattg ctgagcgtat tcgagaatta tccactatta
    14161 aagttctggg attttacgat caggaggtca ccttatatat ttatcgagaa actatttcgc
    14221 tatccctagt aggcattctt ttaggtatct atttaggaaa aggcctgcat acttatatca
    14281 tgacaatgat ttcaactggg gatattcaat ttggtgtaaa ggttgatgct tatgtttatc
    14341 tagtgccaat tctagtaatc cttagcttgt tagcggtatt aggtatctgg gttaattgcc
    14401 atttaaaaaa ggttgatatg ttagaagctt tgaaatccat agattgattg gtgaaaagac
    14461 agagatagac agcacttgaa aagttaatca tattatgata gtatctaaat actataattt
    14521 aatagaaaga tactatgtat ggaaaatagc attgaggcct atctagcaga tagcagagaa
    14581 aaggtaacat taggtacagt tgttgattgt tttaaaggaa aagcagtctc aagtaaggtt
    14641 gtgccaggtg atgtgggatt gattaattta tctgacatgg gcaccttagg aattcaatat
    14701 caccaattaa gaactttcca gatggatcgt aggcagctct tgcgttacct tttggaagac
    14761 ggagatgtct taatcgcctc taagggaacc ctaaaaaaag tctgtgtttt tcataagcaa
    14821 aatcgagatg tggtggcatc atcaaatatc actgtcttac gccctcaaaa actgttaagg
    14881 ggctactata tcaagttctt tttggactta cctattggtc aagcgctctt ggacgcagcg
    14941 gaccatggca aagatgtgat caatctctca acgaaagaat tgttggatat tccaattccc
    15001 gttattcctt tagtgaaaca ggattatttg attaatcact acttgagagg attaacagat
    15061 tatcatcgta aactcaatcg agcagaacag gagtgggaat atattcagaa tgaaattcaa
    15121 aaaggattag gttaggagtc ttgtcatggg ttcagttgaa cgtacattaa aaatgacctt
    15181 ggctaccatt gttgccattt taattgctta ccaacttcat ctggattatg caatgtcagc
    15241 ggggatcatt gccctgttaa gtgttttaga cacccgtaag tccagtttgg tggtcgctag
    15301 gaatcgcttg ctatcttttt tcctggcttt tgggattgcg atgatgtgct ttagcttgtt
    15361 tggttttacg acagtaggtt ttatgtgtta tttgttaatt attattcctt tgctctatca
    15421 ctttcagata gaggcaggac tggttcctat aacagtactt gtgacacatt tgattgctaa
    15481 aaagagtatt gcattaccta ttttatcgaa tgagtttatg ctcttttttg tagggactag
    15541 tgtcgcttta ctatttaatg cttatatggg ttcacaagat cagcaaattc ggtactatca
    15601 ccaaaaagtt gaatcggatc tgaaaggtat cttataccgt tttgaaagtt ttctactgga
    15661 aggaaaaggt caaaatgaag ggctcttgat caaaaacctt gataaaatat tagatgaagc
    15721 tctaaaacta gtttatcgag aaaggcataa tcaactattt cagcagacca attatcaagt
    15781 tcattatttt gagatgcgac gacaacaaaa tagactattg ggacaaatgg ctatcaacgt
    15841 aaacacgtta atgagacaaa gtaaggaaag tattcttttg tcacatcttt ttcacgaaac
    15901 tgcttgtcag ctaagcgaac aaaatccggc tttaaccttg attgatgaca tcgaacaatt
    15961 gcttgaaacc tttcgtcatg gtgatcttcc tcaaactcgg gaggaatttg agcgacgtgc
    16021 ggttttattt cagctcttac aagacttaga gcgctttatc ttattaaagg tagagtttta
    16081 tcaggattat caaaatgact aaatctctat tgcacacttc ttatctatga cagcttggga
    16141 cttaacttcc tgagcttttt tgctataata aaaagaagaa tctcagaatg gagacaagat
    16201 gaacgaaata aaatgccctc attgtcatac cctatttact atcaatgagt cagagtatag
    16261 tcaattattg gaacaagtca gagggcaagc ctttgatgaa gaattgcaaa aacggctaat
    16321 caatgagata gccttgctag aagaaaaagc gaagcatcaa ttgcatgagg ttgtcgcaaa
    16381 aaaagaaata gctattacca gcttgacaaa ccaattagag caaattgaaa aagaacaagc
    16441 ctacctcaga caagaagaac tggctaaaaa agaccagctt attgcttctt tagaagcgaa
    16501 acttgataaa ttggcctcac aaaatgcttt ggaactggcc aatcaattag ctgagaagga
    16561 caaagaagtg gttagtttga ccaatcagct ggacaaatta gcacttgaaa aagatgccac
    16621 gttccagtca aaacttgcta caatcgaaaa agaacgcgat ggaatcaaaa accaattggc
    16681 gcttcaagct aaagaaagtg aattgtcgtt ggcttcggtg cgcagcgact acgaagcaca
    16741 gttaaaagcg gctaacgagc aagttgaatt ttataaaaat ttcaaagcgc agcaatctac
    16801 caaagcaatc ggagagagtc tagaactcta tgctgaaaca gagttcaata aagtaagaag
    16861 ctatgctttt cccaatgcta gctttgtcaa agataaccaa ttgtctagtc gtgggtcaaa
    16921 aggggactat atttaccgag aggttgatac caatggtgta gaaatcctct ctatcatgtt
    16981 tgagatgaag aacgaggcag acaccaccaa aacaaaacat aaaaatagtg attttttcaa
    17041 ggagttagat aaagaccgtc gcgaaaaaga ttgtgagtat gctgttttgg taagcatgtt
    17101 agaagctgat aatgattact acaatacagg gattgttgat gtcagtcatg agtatcaaaa
    17161 gatgtatgtg gttcgtcctc aactctttat tcagttgata gggattctgc gaaatgcagc
    17221 cctgaatagt ttacattata agcaagagtt ggccttgatt aaggaacaaa atattgacat
    17281 cactcacttc gaagaggatt tggatcaatt taagaatgcc tttgctaaga actatcagtc
    17341 tgccagcaac aactttaaaa aggctattga cgagattgat aaatcgatta aacgcatgga
    17401 ggaagtgaaa cgctttttaa ccactagtga aaatcagtta cgcttagcta ataataaatt
    17461 agaggatgtt tcagttaaaa aactgacccg ccaaaaccca accatgcgag agaaatttga
    17521 agccctcaag gaccagtaag cctgaaagtg agtctttccc tgctaaaatt ggttaagcgt
    17581 ttattttggc aaaactgatg ataaagcggt agaatagaat cagtaataat tactaattag
    17641 agagaaaaat agacatgata aatggaatca ttaatttaaa aaaagaagcc ggcatgacct
    17701 ctcatgacgc agtttttaaa ttacggaagt tgttacaaga aaaaaagatt ggacatgggg
    17761 ggaccttaga tcctgatgtg gtcggtgttc taccaattgc agttggtaag gctactcgtg
    17821 tgatcgaata catgacagaa gctggtaaag tttatgaagg acaagtgact ctcggttact
    17881 caacaacgac tgaggatgct agtggagagg tagttgcgag gtcctctttg ccagctgtgc
    17941 taacagaaga actcgttgat caaacgatga cgactttcct tgggaaaatc acacagaccc
    18001 cacctatgta ttcagccgta aaggttaatg gccgtaaatt atacgagtat gcgcgtgctg
    18061 gtgaaagtgt ggaacgtcct agaagagaag tgactatttc tctgtttgaa cgcaccagcc
    18121 ctttgaattt tactgaagac ggtctttgcc gattctcttt taaagttgct tgtagcaaag
    18181 ggacttatgt gcggacctta gcagttgatt taggtcgagc tctaggggta gagagtcata
    18241 tgtccttctt gcagcgatca gcttcagcag gattaaccct cgagactgcc tatactttgg
    18301 gagaaattgc tgatatggtt tctaaacaag agatgtcttt tttgttaccg atcgagtatg
    18361 gcgttgctga tcttcctaaa atggttattg atgatactga attgactgaa atttcatttg
    18421 gtcgccgtct tagtctccct agtcaagagc cactgttagc tgcttttcat ggcgaaaaag
    18481 taattgctat tttagaaaaa agagatcaag aatacaaacc caaaaaagtt cttatttaaa
    18541 tagtttgagt aagtagaatg gataattatg gaaattgaat atatcaaaga ttatcgtgat
    18601 attaaccaag aagatgatac agtcttgata ttgggatatt ttgatggatt acaccgtggt
    18661 cataaagcct tatttgacaa agcaagagag gttgcaaata aagaagggtt aaaagtagtc
    18721 gtttttacgt ttacagagtc tccgaaattg gctttttcgc gtttttctcc tgagttattg
    18781 cttcatatta cttatccaaa gaagcgttat gaaaaatttg ccgattacgg tgtaaataaa
    18841 ttatatttgg ttgattttac ttctaaattc tctaaggtct catctgatca ttttataact
    18901 cattatatta aaaacctgaa agcaaagcat attgttgtcg gttttgacta taagtttggg
    18961 cataatcgta cagatagtga ttatttaacc agaaattttg aaggacaagt ttataccatt
    19021 gaggaaataa aagaagatca tcgaaaaatt tctgctacat ggataaggaa gcttattcaa
    19081 gaaggtaatg tagttaaagc aaaccacttg ttaggctatg acttatcgac aaggggaaga
    19141 gtcgttcacg gggatgcgcg tggccgtact attggtttcc caacagccaa tctagctcca
    19201 attgacaaca catacttacc agctgatgga gtctatgtta caaatgttat tgttgctaat
    19261 aaaatctatc gctctatgac gagtttaggt aaaaatgtga catttggggg gaaagagttg
    19321 cgtctagaag ttaacatttt tgactttgac gaagagatct atggagaaat tattgagatt
    19381 gtttggttag ataaggttcg agacatggaa aaattcgagg gaatcgaaga tttgactgat
    19441 agattggaat atgataaacg aacagcatta aattggaaaa aagatagcaa attatcttaa
    19501 atttttgtat aataaggtaa gtaaatttga tagaggaaaa atatggttac cttattttta
    19561 tcacctagct gtaccagttg tcgtaaagca agggcatggt tagtaaaaca cgaagttgac
    19621 tttcaagagc ataatattat tacaagtcca ttaagccgtg atgaattaat gtcaatcctc
    19681 tcttttacag agaatggaac ggaggatatt atttcaacac gttcaaaggt ttttcaaaaa
    19741 cttgatattg atgtagaaga gctttcaatt tcagatttaa ttgatttaat tgctaaaaat
    19801 ccaagtcttc ttcgtcgccc tattatcatg gatcaaaaac gcatgcaaat tggttttaat
    19861 gaagatgaaa ttagagcgtt tttatcgaga gattatcgca agcaagaact acgtcaagca
    19921 acgataaaag cagaaattga ggggtgatat gtcaggtaat tattattatc cacttgactt
    19981 aagttggagc actgaagaaa tatcctcagt gcttcatttt ttgaataaag tggagttagc
    20041 atatgaaaaa aaagtagatg caaaacaact actagatagt tataagactt ataaaaccat
    20101 tgtcaaaagt aaagctcagg aaaagcaaat cgaccgtgat tttcaaaaag ttagtggtta
    20161 ttcgacctat caagttgtta aaaaagcgaa ggcaattgag aaaggattct tttcccttgg
    20221 aaactaaata cgcatttgca aggcaaatca ttaaagaagc agggcttttt atcaagtcaa
    20281 aaatgtcaga gcagctagat attcaggtga aaacacaatt tgatgatctg gttaccaatg
    20341 ttgatcaaga aactcaacag ttactgatgg atcgtattca tcagacctat ccttgtgatg
    20401 ccattttagc tgaagaaaat gacgttcgtc accccattaa tcaaggaaat gtttgggtca
    20461 tcgatcccat tgatggaacg gttaacttta ttgtgcaggg atcacagttt gcagtgatga
    20521 ttgcctatta tgaacaagga attggtcaat ttgggcttat ttatgatgtg atggcagatc
    20581 aattactagc tggtggtggt gattttgaag ttactttaaa cggtgataag cttccagctt
    20641 accaagagaa acctttagag cgtagcttaa ttggctgcaa tgcaggcatg tttgccagaa
    20701 atgatcgtaa ccttgctcat ctaattgcaa agactttagg tgtaagggtt tatggtggtg
    20761 caggtatctg catggttaag gtcatgaagc aggaattact ggcctatttt tcatttatcc
    20821 aaccatggga ttacgcagca gcaaaagtac taggcgataa actgggttat gttttactaa
    20881 ctattgacgg atatgagcct gattttcaaa cacgtcaaaa aatcatgttt gttcctaaat
    20941 gccagctcac taggatagcg tcttttctaa caaaggactc tgccgtcaca cttgaagatc
    21001 aatagaaatg atgtcattac caaaagaatt tattaacact tatcaagcaa tactaggcaa
    21061 agaattagaa gatttcttgg caagttttaa ccaagagccg gtcaatgctt ttcggattaa
    21121 ccccttaaag aatcaactaa aaacctttga acaccccatt ccaaatacct tatggggata
    21181 ttatggtaaa ctatctggca agtctccaga gcatgtgtcg gggttggttt attcccaaga
    21241 accagcggct caaatggtgg cacaagtagc ggctcctcaa aaggggagtc gtgttttaga
    21301 cttggcagct gcaccaggag gaaaatcaac tcatttatta gcttatttag acaatacagg
    21361 tcttttagtc agcaatgaaa tttctaagaa gcgcagcaag gttttagttg aaaatatcga
    21421 acgttttggc gctagaaatg ttgtggtgac taatgaatcc gcagatcgtt tagccaaggt
    21481 attttctcat tattttgata ctatcgtctt tgatggacca tgttctggtg aaggaatgtt
    21541 tcgcaaggac cctgatgcta ttcaatattg gcatcacggg tatcccgcag aatgcgccaa
    21601 gttgcaaaaa tctattttag aagacgcctt agtcatgtta aaatcaggag gagaattgat
    21661 atactccacc tgtacttggg ctcctgaaga aaatgaagat gttgtgcagt ggctcttaga
    21721 gacttatacc tttttagaat tggtcgatgt tccaaaacta aatggaatgg ttagtggtat
    21781 cggacttcca gagactgcta gaatgtaccc tcatcgttat caaggggaag ggcaatttgt
    21841 ggccaagcta aaagataagc gtcaagaagg acaaagcact aaactaaaag cacctaaatc
    21901 caacttgacc aaagaccagt tacgtctttg gaaaatgttt gaaaaagacc atctaaacct
    21961 taccctatca ggaacactac aaacctttgg tgattaccta tacctcttgc cagatggtct
    22021 tcctgcttta gatggcctta aaattgctcg gaacggttta gaattaggcg tcttcaagaa
    22081 gaaacgcttt gaaccctctt acgccttggg attagcttta aagtctgatg aggtccgatc
    22141 atctattgag cttagagagg aagactttag accttatgtg tcaggtaacg tcattacttt
    22201 gccccaatct tatccaacag gctggtacca attactcatt aatggcaatg gtctaggatt
    22261 tgccaaggtc gttgacaaga ccatcaaaaa taatttccct aaagggttaa gattttagcg
    22321 taaaaaataa gattaaaatg ttaaatattt aaagaaaaaa tgctttcaaa gcataggtag
    22381 atatgttact ataaagaata tgtggcactt agtttctaca tatatacctt ttatttttac
    22441 gaataggaaa taaataatga aaatgaaaaa aaaattcttt ttgttaagtc ttttagccct
    22501 atcaactttc tttttatccg catgttctag ctggattgat aaaggcgagt caataaccgc
    22561 tgtaggatca acagcactac aacccttagt agaagcagta gctgatgaat ttggaagcag
    22621 taatctaggc aagactgtca atgttcaagg tggtggttca ggtacagggt tgtctcaagt
    22681 tcaatcagga gctgtccaaa ttggaaatag tgatgtcttt gcggaagaaa aagatggtat
    22741 tgatgcttct aaattagttg atcatcaagt agctgttgca ggacttgcag ttattgccaa
    22801 tcctaaagtc aaggtttcca atctcagtag tcagcagttg caaaagattt tttcaggaga
    22861 atataccaat tggaaacaag ttggaggaga agatcttgcg atttcagtga tcaaccgagc
    22921 agcaagttct ggctcacgag caacctttga cagtgttatc atgaaagggg tcaacgctaa
    22981 acaaagtcaa gagcaagact ccaatgggat ggttaaatcg attgtttcac aaacaccagg
    23041 tgccatttct tacctttcct ttgcctacgt tgattcatct gttaaatctt tgcaattaaa
    23101 tgggtttaag gcaaatgcta agaacgtggc tacaaatgat tggccaatct ggtcctacga
    23161 acacatgtat accaaagata aaccaacagg gttgaccaag gaatttcttg attatatgtt
    23221 ttcagatgaa gtacaacaga acattgttac acatatggga tatatttcga taaatgatat
    23281 ggaagtggtc aaatctcatg atggaaaagt aacaaaaagg taatggagga attatggaaa
    23341 atcaggaatt ggctaaaaaa ttagcctcac catcaaagaa ttcaagactt gaaacctttg
    23401 gccgcaccat tacgtttttg tgtctggctt tgattgtttt tatcgttgcg atgattctga
    23461 tcttcgttgc tcaaaaaggg ttgtcaacct tctttgttga caaggttaat ctttttgatt
    23521 tcttgtttgg aaaggagtgg caaccaagtg tgaaaaatgc ggccggcatt ccttatcttg
    23581 gtgctctgcc aatgattaca ggatcctttt tggttaccat tttatctgct attattgcca
    23641 ccccatttgc cattggcgca gccgttttta tgactgaaat ctcacctaaa tatggcgcta
    23701 aattattaca gcctgcggtt gagcttttgg ttggaattcc ttcggttgtt tatgggttta
    23761 tcggtttgca agtgattgtt ccttttatgc gctctatctt tggtggcaca ggttttggaa
    23821 tcctatctgg ggtctgtgtc ttgtttgtta tgattttacc aacagtgact tttatgacaa
    23881 cagacagtct gcgggcggtg cctcgtcatt accgcgaagc gtctatggct atgggagcaa
    23941 cccgttggca aaccatttgg cgtgttgttc ttaatgcagc tcgtccaggt atttttactg
    24001 ccattatttt cgggatggcg agagcttttg gtgaagcctt agccattcaa atggttgtcg
    24061 gtaactctgc tgtaatgcca agttcactaa cgacaccagc cgcaacctta acgtctgtct
    24121 tgacaatggg tattggtaac acggttatgg gaacggtcca aaataatgtg ctttggtccc
    24181 ttgccctagt cttattatta atgagtctgg ccttcaattc ccttgtcaaa ttaatcacga
    24241 aagaaagaaa gagaaattat gaacgctaaa aaagtcgata aagtagcaac tggtactctt
    24301 tataccattg ctggaattat tgtagctatt ttagcttcct taattctata tatccttgtc
    24361 cgtggcttgc cacacatcag ctggtccttt ttaacaggaa aatcgtcttc gtacgaagct
    24421 ggtgggggaa ttggtatcca gttgtataat tccttcttcc tattgattgt taccctgatt
    24481 atttccattc ctttatcaac tggagcgggg atttacttgg ctgaatatgc caaaaaaggg
    24541 cctgttacca actttattag aacctgtatt gagattctgt cttccctacc atctgtggtt
    24601 gtagggctct ttggttactt gattttcgtt gtgcagtttg aatatggctt ttctattatt
    24661 tcaggggctc ttgctttgac ggtctttaat cttcctcaaa tgacccgtaa tgttgaagat
    24721 agtttactgc atgttcatca tacccaaaga gaagcaggat tagctttagg cctgtcacgc
    24781 tgggaaacag ttttttatgt ggttatccca gaagctctcc cggggatggt aacaggtatt
    24841 gtcttagctt caggtcgtat ttttggtgaa gcggcagcgc ttatctatac tgctggtcaa
    24901 tcagcaccag ctctggattg gtcaaattgg aatccactta gtgttactag tccaatctct
    24961 attttccgtc aatctgagac ccttgctgtt catatttgga aagtcaatag cgaagggaca
    25021 attccagatg ctactcttgt atccgcagga agtgcagcag tgctattaat ttttatcctt
    25081 attttcaact tttcagctcg ctttattggg aagaaacttc attctaaaat gacagcagcg
    25141 aaataagata ttggagaaat catgacagaa tataattgga atgaacgtca tatcatcact
    25201 tttcctgaag aaacgcttgc tctagctacc aaggatttac atgtttacta tggtgcgaaa
    25261 gaagctatca aagggattga tatgcagttt gaaaaacata aaataacagc cttgattggt
    25321 ccatctggtt gtggcaaatc aacttatctt cgtagtctta accgcatgaa cgataccatt
    25381 gatattgctc gggttacagg tgagattctt tatcagggca ttgatgttaa tcgaaaagac
    25441 atgaatgttt acgagattcg caagcactta ggaatggttt ttcaaagacc caatcctttc
    25501 gctaaatcca tttataaaaa cattaccttt gcccatgaaa gagctggtgt gaaagacaaa
    25561 aaggttttag atgaaattgt tgagacttca ctgaaacaag ccgcgctttg ggatcaagtt
    25621 aaagatgacc ttcacaaatc agccttcacc ttatcagggg gtcagcaaca acgcttgtgt
    25681 attgctagag ccatttctgt caaacctgat attctattaa tggatgaacc agcctctgcc
    25741 cttgacccga ttgcaacgat gcagctggaa gaaaccatgt ttgaattgaa gaagaattac
    25801 acgattatta ttgtgaccca caatatgcaa caagcagctc gtgccagtga ttacactgcc
    25861 ttcttctatt taggcaacct cattgaatat gataagacac gtaatatttt ccaaaatgcg
    25921 caatgtcagt caacaaacga ctacgtttca gggcactttg gttagaaagg taatatgatg
    25981 acagaaccta ttttacagat cagagacctt tctgtttact acaatcaaaa gaaaacgtta
    26041 aaagatgtct ctttggacct ttatccaaat gaaataacag ctttaattgg tccttctgga
    26101 tctgggaaat caacgctctt gcgttctatc aaccgtatga atgatttgaa tcctgaagta
    26161 accattacag gctctatcgt ctataacgga cacaatattt atagtccaag gacagatacg
    26221 gttgatctac gcaaagaaat tggtatggta ttccaacaac ccaacccatt tccgatgtct
    26281 atttatgaga acgtggttta cggccttcgc ttaaaaggta tcagagataa atcaatctta
    26341 gaccatgctg ttgaaagctc tcttaaaggg gcttccattt ggaatgaagt caaagatcgt
    26401 ttacatgatt ctgcggttgg cttatcaggc ggacagcaac agagagtttg catagctaga
    26461 gttcttgcta ccagccccag aataatcctt ttagatgaac ctacctcagc tcttgatcct
    26521 atctcagctg ggaaaattga agaaacatta ttgttattaa aaaaagatta tacactggct
    26581 attgtgaccc gctcaatgca gcaagcctca cgtttatcag atcgaacagg ttttttcttg
    26641 gagggtgact tacttgagtg tggtcctaca aaagctatgt ttatgaatcc taagcgcaaa
    26701 gaaaccgaag actatatttc tggtaaattt ggttgagaaa gacgtatatg gttgacccct
    26761 ctgtgttttt attataatga ctagattgta ggaagaaaaa atcatgttaa gaacgaaatt
    26821 tgaagaagaa ttagataaat tgcataacca gttttattca atgggaacgg aagtattggc
    26881 acaaatcaat aaaactgttc gtgcctttgt tagtcatgat cgtgaattgg ccaaagaagt
    26941 tatcgaagaa gatgacacta ttaataattt tgagacaaag cttgaaaaga aatcgctgga
    27001 aattattgcc ctacaacagc cagtttcgaa tgatcttaga atggttatta ctgttttaaa
    27061 ggcatcaagt gatattgaac gtatgggtga ccatgctgct tcgattgcca aggccactat
    27121 tcgtatgaaa ggtgaggagc gtattccagt ggttgaagaa caaatcaacc ttatgggaaa
    27181 agctgtgaaa cagatggtag aagaagccct taatgcatat atcaatgctg acgatacaaa
    27241 agcttatgaa atcgcagctt ctgatgagat tatcgatcaa tatttccgta atatccaaac
    27301 cttagctgtt gaagaaatcc gtaagtctcc agatgctgtt tttgcaggaa aagaatattt
    27361 tcaagtatta atgtatttgg aacgtattgg tgactatgct cgcaacattt gtgaatggat
    27421 tgtttatctt aaaactggaa aaattattga attataagaa attatgctat aatgagactg
    27481 ggaaacagct tgccagtccc tggttttata cgaaattgtg caagttagaa aatgaactaa
    27541 caagaaaagt tttctttgct gaatctgatt ttgttaggtt aacaaatata tgtagacaga
    27601 gatgatactt aggtatcatc tgttgatcta ttatgatttg ttattagaat taaggagtta
    27661 tatgaagaca gtagaacatc tcatcgaaac atttgtgcct gaaaattata acatcttttt
    27721 agatattaat cgtcagacta aaacatttac ggggaatgtt gcgattaatg gtgaagcttt
    27781 agataatcat gtggctttcc accaaaaaga tttggacatt aagtctattt tgctcgataa
    27841 tgaagctgtt atttatcaag tggataacga caatgaagtt gtgcgtgttg aattacctga
    27901 aacaggaatg atgacgcttg tcattgaatt ttcaggtagc attacagata atatgacagg
    27961 tatttaccct tcatattaca ctaaaaatgg tgagaaaaaa gaagtcattt caactcagtt
    28021 tgaaagccat tttgcacgtg aagctttccc atgtatcgat gaaccacaag caaaagctac
    28081 ttttgattta agcttgacct ttgatcaaga aattggtgag atagcgttat cgaatatgcc
    28141 agaagtcaat attgaccgtc gcgaggagac tggtctttgg acatttgata cgacaccaag
    28201 aatgtcatct tacttgctag cgtttgcgct aggagaactt catggaaaga ctgtagaaag
    28261 caaaaaagga acaactgttg gtgtgtatgc gacaacagcg catcctctta gctcgcttga
    28321 tttttcattg gatattgcag ttcgtgttat taacttttat gaagactatt ttggagtaca
    28381 ttacccaatc ccgcaatctc ttaatattgc gcttccagat ttttcatctg gtgctatgga
    28441 aaattggggt ttaatcactt atcgtgaaat ttatttatta gtagatgaaa attcgactgt
    28501 tcaaagccga caacaagtgg cacttgtaat cgcccacgag atagcacacc aatggtttgg
    28561 aaacttggtt acaatgaaat ggtgggacga tctgtggtta aatgagagtt ttgccaacat
    28621 gatggaatat gtctctatcg aggctattga gccgtcttgg aaaataatag aagatttcca
    28681 aacaggcggt attcctcttg ctttaaaacg tgatgctact gatggtgttc aatcagtgca
    28741 tgttgaagtc aatcatccag atgaaataaa tacattgttt gatcctgcta ttgtctatgc
    28801 aaaaggtagt cgtttgatgc atatgttacg ccgttttatt ggtgatcgtg attttgccat
    28861 tggcttacat cactactttg aaaaatatca atatcgaaat actgtcgggc gtgatttatg
    28921 gaatatttta tcagatactt caggcaaaga cgtagctgct tttatggatg cttggcttga
    28981 acaaccaggt tatccagttt taacagctcg ccttgaaaac gatcaattga ttttgagtca
    29041 aaaacaattt tttattggaa aaggtgaaga aaaaggtcgc ctttggccga ttcctttaaa
    29101 cactaattgg catggccttc ctgaaacttt gacagaggca gaaatggtca ttccaaactt
    29161 tagtcaattg gcagcagaaa atgaaggagc tctacgtttc aatattgata atacagctca
    29221 ttacattaca gattaccaag gatcattatt agatgcctta gtcactgaac ttgcccaact
    29281 tgataatact tctgctttac aagttattca agaacgtcgt ttattggcag atagtggctt
    29341 gatttcctat gctgaattgg ttgacttaat tgctcaattg gacgattcta agtcttatat
    29401 ggtagcagaa gcggttcagc aagtggtctc tggtttgaaa cgcttcattg atgaaggaag
    29461 cttagcagaa aaatccttta atcgcttggt aaccaccatc tatcaagaag actttaatca
    29521 gcatggtttt gagaaaaaag ctgacgaatc agatgaagat gagatggtac gtcaggttgc
    29581 cttgggccgc ttgtggctag cagaaaatca gacgattatt gacggattga gaactatttt
    29641 tgaagcatat caaaacaata ttgcaagtat tccagcagct gttcgtcgct tggttttagc
    29701 caaccaaatg aaatattttg aaacagatag cttggttgat atttattttg agacttatgt
    29761 agcaactact gataataatt tacgcagtga tttaacggtt gcttttagtc aaacaaaaca
    29821 accaactact attagacgta ttcttgttag tttaaaagat aaagatatta ttaaacctca
    29881 ggatttatct tattggtaca atgctttgct tggacaaagc tttactcaag atatcatttg
    29941 ggaatgggct agagaaaatt gggattggat taaatctgca cttggaggag atatgagctt
    30001 tgataaattt gttatttatc cagcaagtaa ctttaaaaca ccaaaacatc tagcagaata
    30061 taaatctttc tttgaaccta agctagatga tatggctatt agccgtaata ttaccatggg
    30121 aattaatgaa attgaagcac gtgttgcttt gatcactaaa gaaaaagaag cagttattgc
    30181 agctctcagt cattactaga ccataagcaa aagagttggg gggactttcc agctcttttt
    30241 tgtagtgagc tagcttcctt tcttagttcc gtctataact aaatgattat ccatagttta
    30301 attcaaaagg agattgcact ttaaagcgaa ggctattagc ctcttaaata cttttttacc
    30361 aggtggtgaa taagaacaat tataaatgat ttaatcatta tgctttaaat gccttaaagg
    30421 agtattaata ttttagtaaa ccttaagctt tttgtagtat agtctcgtta gaaattgtta
    30481 tcagaaatga gactaagtta aatgaagtga tagttacttt atttaagaac aattgaggta
    30541 gagacatgat aaaaatatta ttagtagaag atgacttgag cttatcaaat tccatttttg
    30601 attttttaga tgattttgca gacgtcatgc aagtttttga tggcgatgaa ggtttatacg
    30661 aagcagaaag tggtatttat gatttgattt tgttagacct tatgttgccg gagaaaaatg
    30721 gctttcaagt cttaaaagaa ttgcgagaaa aagatattaa aattcctgta ttgatcatga
    30781 cagctaaaga gggtttagat gataaaggtc acggatttga attaggtgct gatgattatc
    30841 tgacaaagcc gttctattta gaagagttaa aaatgcgaat tcaagcactg ttaaaaagaa
    30901 cagggaaatt tgcagataaa aatattagtt ttggcaattt agtggtcgac ttagctcgaa
    30961 aagaggtgaa ggttgaaggg aaagtagttg aattacttgg caaagaattt gatttgttgg
    31021 tgtatctttt gcaaaatcaa aacgttattt taccaaagac acaaattttt gatcgtttat
    31081 ggggattcga tagtgatact acgatttcgg ttgttgaagt ttacatttct aaaataagga
    31141 aaaaattaaa aggtacccgt tttgttaaca ggcttcaaac tttaagaagc gtagggtata
    31201 ttctaaaaaa caa
//
LOCUS       DAUDWO010000025        31185 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.025, whole genome shotgun sequence.
ACCESSION   DAUDWO010000025 DAUDWO010000000
VERSION     DAUDWO010000025.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 31185)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31185)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31185
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.025"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            1010..1318
                     /locus_tag="VHC05_001092"
     CDS             1010..1318
                     /locus_tag="VHC05_001092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-diphosphocytidyl-2C-methyl-D-erythritol
                     kinase"
                     /protein_id="HEQ5402409.1"
                     /translation="MKHRFQVKRGVSVYLEKRIPMCAGMGGGSSDAVTIRALNQLWLL
                     TLSRKDMMDIGIPIGSDVPYCLLSGCAQVTGKGEVVCRILGLLSSWVVLVKPDFGIST
                     "
     gene            1373..1585
                     /locus_tag="VHC05_001093"
     CDS             1373..1585
                     /locus_tag="VHC05_001093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-diphosphocytidyl-2C-methyl-D-erythritol
                     kinase"
                     /protein_id="HEQ5402410.1"
                     /translation="MVAAIEAGNYNDGILTEMNNLLEDIFIAKRPFIQKIKEKTLQAG
                     AATVLMTGSGPTVFALCQTEKQTIIV"
     gene            1695..2138
                     /locus_tag="VHC05_001094"
     CDS             1695..2138
                     /locus_tag="VHC05_001094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent MarR family transcriptional
                     regulator"
                     /protein_id="HEQ5402411.1"
                     /translation="MGTLEKKLDNLVNTILLKAENQHELLFGACQSDVKLTNTQEHIL
                     MLLSQQRLTNTDLAKALNISQAAVTKAIKSLVKQDMLAGTKDTVDARVTYFELTELAK
                     PIASEHTHHHDETLNVYNRLLQKFSAKELEIVDKFVTVFAEELEG"
     gene            2142..2861
                     /locus_tag="VHC05_001095"
     CDS             2142..2861
                     /locus_tag="VHC05_001095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402412.1"
                     /translation="MRYISVENLSFQYESEPVLEGITYHLDSGEFVTMTGENGAAKST
                     LIKATLGILQPKAGRVTIAKKNKDGKQLRIAYLPQQVASFNAGFPSTVYEFVKSGRYP
                     RSGWFRHLNKHDEEHVQASLEAVGMWENRHKRIGSLSGGQKQRVVIARMFASDPDIFV
                     LDEPTTGMDSGTTDTFYELMHHSAHQHGKSVLMITHDPEEVKAYADRNIHLVRNQKLP
                     WRCFNIHEVETDDEKGGHGHA"
     gene            2854..3669
                     /locus_tag="VHC05_001096"
     CDS             2854..3669
                     /locus_tag="VHC05_001096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HEQ5402413.1"
                     /translation="MLDILSYDFMQRAVMAVVAISIFAPILGIFLILRRQSLMSDTLS
                     HVSLAGVALGVVLGISPTITTIIVVVLAAILLEYLRVVYKHYMEISTAILMSLGLALS
                     LIIMSKSHSSSSMSLEQYLFGSIITISMEQVVALFAIAAIILILTVLFIRPMYILTFD
                     EDTAFVDGLPVRLMSVLFNIVTGVAIALTIPAAGALLVSTIMVLPASIAMRLGKNFKT
                     VILLGIVIGFSGMLSGIFLSYFFETPASATITMIFISIFLLVSLGGMLKKRLF"
     gene            complement(3709..4092)
                     /locus_tag="VHC05_001097"
     CDS             complement(3709..4092)
                     /locus_tag="VHC05_001097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HEQ5402414.1"
                     /translation="MTECIFCHQLKANQLLTQSQYFKVVFDIDPIQKGHLLLISKDHY
                     TSLTQLPKEVRYDLINLQAALVAKLEQHLPISGVTSVSNDKELMDEGTHFHLHLIPRL
                     TNDSFWEGITINQENWDLTPFLKHL"
     gene            complement(4143..5399)
                     /locus_tag="VHC05_001098"
     CDS             complement(4143..5399)
                     /locus_tag="VHC05_001098"
                     /EC_number="6.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine--tRNA ligase"
                     /protein_id="HEQ5402415.1"
                     /translation="MNIFEELKARGLVFQTTDEQALVKALTEGQVSYYTGYDPTADSL
                     HLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKETVLEWSDKIK
                     GQLSTFLDFENGDNKAELVNNYDWFSQISFIDFLRDVGKYFTVNYMMSKDSVKKRIET
                     GISYTEFAYQIMQGYDFYELNDKHNVTLQIGGSDQWGNMTAGTELLRKKADKTGHVMT
                     VPLITDSTGKKFGKSEGNAVWLDADKTSPYEMYQFWLNVMDDDAVRFLKIFTFLSLDE
                     IAEIETQFNAARHERLAQKTLAREVVTLVHGEEAYKQALNITEQLFAGNIKNLSANEL
                     KQGLSNVPNYHVQSIDNHNIVEILVAAKISPSKRQAREDVQNGAIYINGDRVQDLDYQ
                     LSNDDKIDDQLTVIRRGKKKYAVLTY"
     gene            5491..7803
                     /locus_tag="VHC05_001099"
     CDS             5491..7803
                     /locus_tag="VHC05_001099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEQ5402416.1"
                     /translation="MRYFMVKWNTKQKRISHQRLGLLDLGPVLLRTLRLLSNFFYIVI
                     FLFGMMGFGMAFGYLASQIESVKVPSKESLVKQVESLTMISQMNYSDNSLISTLDTDL
                     LRTPVANDAISENIKKAIVSTEDEHFQEHKGIVPKAVFRATLASVLGFGEASGGSTLT
                     QQLVKQQVLGDDPTFKRKSKEIVYALALERYMSKDNILCDYLNVSPFGRNNKGQNIAG
                     VEEAARGIFGVSAKDLTVPQAAFLAGLPQSPIVYSPYLSTGQLKSEKDMAYGIKRQQN
                     VLYNMYRTGVLSKKEYEDYKAYPIQKDFIQPGSAIVNNHDYLYYTVLADAKKAMYSYL
                     IKRDKVSSRDLKNDDTKAAYEERALTELQQGGYTITTTINKPIYNAMQTAAAQFGDLL
                     DDGTGTVQMGNVLTDNATGAVLGFVGGRDYALNQNNHAFNTVRSPGSSIKPIIAYGPA
                     IDQGLMGSASVLSNYPTTYSSGQKIMHADSEGTAMMPLQEALNTSWNIPAFWTQKLLR
                     EKGVDVENYMTKMGYKIADYSIESLPLGGGIEVSVAQQTNAYQMLSNNGLYQKQYIVD
                     KITASDGTVVYKHENKPIRIFSAATATILQELLRGPITSGATTTFKNRLAAINPWLAN
                     ADWIGKTGTTENYTDVWLVLSTPKVTLGGWAGHDDNTSLAPLTGYNNNSNYLAYLANA
                     INQADPNVIGVGQRFNLDPGVIKANVLKSTGLQPGTVNVNGHTFSVGGEMTTSLWSQK
                     GPGAMTYRFAIGGTDADYQKAWGNFGFRKN"
     gene            8067..11633
                     /gene="rpoB"
                     /locus_tag="VHC05_001100"
     CDS             8067..11633
                     /gene="rpoB"
                     /locus_tag="VHC05_001100"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003055252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HEQ5402417.1"
                     /translation="MAGHEVRYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFQDFLDSG
                     LKEVFEDVLPISNFTDTMELEFVGYEFKEPKYTLEEARIHDASYSAPIFVTFRLVNKE
                     TGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGS
                     TVIPNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIVDIFGESDLVR
                     NTIEKDIHKNPSDSRTDEALKEIYERLRPGEPKTADSSRSLLIARFFDARRYDLAAVG
                     RYKVNKKLNIKTRLLNQIIAENLVDAETGEILVEAGTEMTRSVIESIEEHLDGDLNKF
                     VYTPNDYAVVTEPVVLQKFKVVSPIDPDRVVTIVGNANPDDKVRALTPADILAEMSYF
                     LNLAEGLGKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNDVLTPQ
                     QIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVR
                     DVHYTHYGRMCPIETPEGPNIGLINNLSSFGHLNKYGFIQTPYRKVDRATGRVTNEIV
                     WLTADEEDEYTVAQANSKLNEDGTFAEEIVMGRHQGNNQEFSASVVDFVDVSPKQVVA
                     VATACIPFLENDDSNRALMGANMQRQAVPLIDPKAPYVGTGMEYQAAHDSGAAVIAQH
                     NGKVVFSDAEKVEIRRQDGSLDVYHITKFRRSNSGTAYNQRTLVKVGDIVEKGDFIAD
                     GPSMENGEMALGQNPVVAYMTWEGYNFEDAVIMSERLVKEDVYTSVHLEEFESETRDT
                     KLGPEEITREIPNVGEEALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERL
                     LHAIFGDKSREVRDTSLRVPHGGDGIVRDVKIFTRANGDELQSGVNMLVRVYIAQKRK
                     IKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHL
                     GMAARNLGIHIATPVFDGASSEDLWDTVREAGMDSDAKTVLYDGRTGEPFDNRVSVGV
                     MYMIKLHHMVDDKLHARSVGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVL
                     QEILTYKSDDVTGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDN
                     EVELRDLDEGEDDDIMHVDDLEKAREKQAQETQEVSETTDEK"
     gene            11724..15365
                     /gene="rpoC"
                     /locus_tag="VHC05_001101"
     CDS             11724..15365
                     /gene="rpoC"
                     /locus_tag="VHC05_001101"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020904830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HEQ5402418.1"
                     /translation="MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPERE
                     GLFDEVIFGPTKDWECACGKYKRIRYKGIVCDRCGVEVTRAKVRRERMGHIELKAPVS
                     HIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEPKSLLTEREYREKLQ
                     EYGHGSFVAKMGAEAIQDLLKRVDLAAEIAELKEELKSASGQKRIKAVRRLDVLDAFN
                     KSGNKPEWMVLNILPVIPPDLRPMVQLDGGRFAASDLNDLYRRVINRNNRLARLLELN
                     APGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLG
                     KRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVAKEYAGNVKAAKRMVE
                     RGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNAD
                     FDGDQMAIHVPLSEEAQAEARLLMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEDA
                     GREGEGMIFKDKDEAVMAYRNGYAHLHSRVGIAVDSMPNKPWKDSQRHKIMVTTVGKI
                     LFNDIMPEDLPYLQEPNNANLTEGTPDKYFLEPGQDIQEVIDGLEINVPFKKKNLGNI
                     IAETFKRFRTTETSAFLDRLKDLGYYHSTLAGLTVGIADIPVIDNKAEIIDAAHHRVE
                     EINKAFRRGLMTDDDRYVAVTTTWREAKEALEKRLIETQDPKNPIVMMMDSGARGNIS
                     NFSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADS
                     GYLTRRLVDVAQDVIIREDDCGTDRGLLIRAITDGKEVTETLEERLQGRYTRKSVKHP
                     ETGEVLIGADQLITEDMARKIVDAGVEEVTIRSVFTCATRHGVCRHCYGINLATGDAV
                     EVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRIQEIFEARNPKGEAV
                     ITEVKGNVVEIEEDASTRTKKVYVQGKTGMGEYVVPFTARMKVEVGDEVNRGAALTEG
                     SIQPKRLLEVRDTLSVETYLLAEVQKVYRSQGVEIGDKHVEVMVRQMLRKVRVMDPGD
                     TDLLPGTLMDISDFTDANKDIVISGGIPATSRPVLMGITKASLETNSFLSAASFQETT
                     RVLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNIEPQAMNEIEVIDHTEVSA
                     EAVFTAEAE"
     gene            15517..15882
                     /locus_tag="VHC05_001102"
     CDS             15517..15882
                     /locus_tag="VHC05_001102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1033 family protein"
                     /protein_id="HEQ5402419.1"
                     /translation="MYQVIKMYGDWEPWWFIDGWQDDIIDEQQFSDWQEALDYFNQEW
                     QRMKAIFPSYHSQKNLLATFWEKEDKRWCEDCDEDLQQFHSLLLLKNKDIVPSNNYIP
                     EFEQRNDSPQVAYLCKLNL"
     gene            15975..16913
                     /gene="tadA"
                     /locus_tag="VHC05_001103"
     CDS             15975..16913
                     /gene="tadA"
                     /locus_tag="VHC05_001103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Flp pilus assembly complex ATPase component
                     TadA"
                     /protein_id="HEQ5402420.1"
                     /translation="MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVD
                     VYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYKLSKDKQLSLRLSSVGDYRGQES
                     LVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISSYHQEA
                     QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAV
                     IRASLTGAMVFSTVHAKSISGVYARLLELGITKAELSNCLALIAYQRLLNGGALIDST
                     QNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII"
     gene            16897..17883
                     /locus_tag="VHC05_001104"
     CDS             16897..17883
                     /locus_tag="VHC05_001104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HEQ5402421.1"
                     /translation="MKKLSSKHQHKFIQLLANLLSTGFSFAEVIAFLKRSQLLQLDYV
                     LKMEESLLKGQGLADMLSGLGFSDAILTQISLADRHGNIETTLVAIQHYLNQMARIRR
                     KTVEVITYPLILLLFLFVMMLGLRRYLVPQLETQNQITYFLNHFPAFFIGFCSGLILL
                     FGMVWLRWRSQSRLKLYSRLSRYPFLGKLLKQYLTSYYAREWGTLIGQGLDLMTILDI
                     MAIEKSSLMKELAEDIRMSLLEGQAFHIKVATYPFFKKELSLMIEYGEIKSKLGAELE
                     IYAQESWEQFFSQLYQVTQLIQPAIFLVVAVTIVMIYAAILLPIYQNMGGIF"
     gene            17885..18211
                     /locus_tag="VHC05_001105"
     CDS             17885..18211
                     /locus_tag="VHC05_001105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HEQ5402422.1"
                     /translation="MINQWNNLRHKNLKGFTLLEMLLVILVISVLMLLFVPNLSKQKD
                     RVTETGNAAVVKLVENQAELYELSQGSKPSLSQLKADGSITEKQEKAYQDYYDKHKNE
                     KARLSN"
     gene            18186..18614
                     /locus_tag="VHC05_001106"
     CDS             18186..18614
                     /locus_tag="VHC05_001106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system protein"
                     /protein_id="HEQ5402423.1"
                     /translation="MKKPVLAIKAFTLLETLLSLSVMSFIILGLSVPVTKSYQKVEEH
                     LFFSHFEHLYRHQQKLAILQQKQRVLDISSTKIVTEGNSLTVPKSITVNHPYRLVIDQ
                     MGGNHSLAKIIFDMTDRRFKYQFYLGSGNYQKTSQSLHSP"
     gene            18619..18855
                     /locus_tag="VHC05_001107"
     CDS             18619..18855
                     /locus_tag="VHC05_001107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComG"
                     /protein_id="HEQ5402424.1"
                     /translation="MIATGILFSIVILILSSLQQSQAALTYYRKQQEKLNLALMAVQT
                     RTKEMTLNGCHITILRTDRYISIHDDEGEVMKIE"
     gene            18848..19282
                     /locus_tag="VHC05_001108"
     CDS             18848..19282
                     /locus_tag="VHC05_001108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComGF"
                     /protein_id="HEQ5402425.1"
                     /translation="MSKQLSNIKAFTLLEALIALLVISGSLLVYQGLTQTLLKRSHYL
                     ARHDQDNWLLFSHQLREELSGARFYKVADNKLYVEKGKKVLAFGQFKSHDFRKSASNG
                     KGYQPMLFGISRSHIHIEQSQICITLKWKSGLERTFYYAFQD"
     gene            19266..19592
                     /locus_tag="VHC05_001109"
     CDS             19266..19592
                     /locus_tag="VHC05_001109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComG"
                     /protein_id="HEQ5402426.1"
                     /translation="MPFKTNLKAGILLYAMFMASIFLLVLQVYLSQVTALHKEYQAQT
                     DYVKARLIAEIVYQDHRYKASNPVFFKGGQVICRERKERWMLIVKLDQQRQYQFEYLK
                     PKQYSQ"
     gene            19690..20643
                     /locus_tag="VHC05_001110"
     CDS             19690..20643
                     /locus_tag="VHC05_001110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEQ5402427.1"
                     /translation="MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEG
                     ASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQTEQLQANHQFTPDAIGFILLYLL
                     EQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
                     AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSL
                     KYLKKDGFAIFLVPVNLLTSPQSQLLKQWLKDYAQVVTLITLPDSIFGHPSNAKSIIV
                     LQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN"
     gene            20702..21898
                     /locus_tag="VHC05_001111"
     CDS             20702..21898
                     /locus_tag="VHC05_001111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="HEQ5402428.1"
                     /translation="MSKTIAINAGSSSLKWQLYQMPEEAVLAQGIIERIGLKDSISTV
                     KYDGKKEEQILDIHDHTEAVKILLNDLIHFGIIAAYDEITGVGHRVVAGGELFKESVV
                     VNDKVLEQIEELSVLAPLHNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLY
                     PIPQKYYTDYKVRKYGAHGTSHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYH
                     GQSADTSMGFTPLAGPMMGTRSGDIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSG
                     VSGISSDMRDIEAGLQEDNPDAVLAYNIFIDRIKKCIGQYFAVLNGADALVFTAGMGE
                     NAPLMRQDVIGGLTWFGMDIDPEKNVFGYRGDISTPESKVKVLVISTDEELCIARDVE
                     RLKNTK"
     gene            22085..22393
                     /locus_tag="VHC05_001112"
     CDS             22085..22393
                     /locus_tag="VHC05_001112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402429.1"
                     /translation="MYVFIESNDLKDYLITVYDERNRAIRKQTQVYCFYLMIVLFVAL
                     FFFFPCLTIRDLVSYKLPLIFAYLYLIIRSLVAKKMEALGKITTNSQKPPFDTSQVLC
                     "
     gene            complement(22476..23246)
                     /locus_tag="VHC05_001113"
     CDS             complement(22476..23246)
                     /locus_tag="VHC05_001113"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HEQ5402430.1"
                     /translation="MKIGIIGVGKMASAIIKGLKQTPHELIISGSSLERSKEIAEQLT
                     LPYAMSHQDLIDQVDLVILGIKPQLFETVLKPLHFKQPIISMAAGISLQRLATFVGQD
                     LPLLRIMPNMNAQILQSSTALTGNALVSQELQARVRDLTDSFGSTFDISEKDFDTFTA
                     LAGSSPAYIYLFIEALAKAGVKNGMPKAKALEIVTQTVLASASNLKTSSQSPHDFIDA
                     ICSPGGTTIAGLMELERLGLTTTVSSAIDKTIDKAKSL"
     gene            complement(23294..24361)
                     /gene="pepA"
                     /locus_tag="VHC05_001114"
     CDS             complement(23294..24361)
                     /gene="pepA"
                     /locus_tag="VHC05_001114"
                     /EC_number="3.4.11.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012766453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamyl aminopeptidase"
                     /protein_id="HEQ5402431.1"
                     /translation="MTDLFSKIKEVTELDGIAGYEHSVRDYLRTKITPLVDRVETDGL
                     GGIFGIRDSKAEKAPRILVAAHMDEVGFMVSDIKVDGTLRVVGIGGWNPLVVSSQRFT
                     LYTRTGQVIPLISGSVPPHFLRGANGSASLPNIENIVFDGGFTDKAEAESFGITPGDI
                     IVPQSETILTANQKNIISKAWDNRYGVLMITEMLEALKGQDLNNTLIAGANVQEEVGL
                     RGAHVSTTKFDPELFFAVDCSPAGDIYGNPGTIGDGTLLRFYDPGHVMLKDMRDFLLT
                     TAEDAGVNFQYYCGKGGTDAGAAHLQNDGVPSTTIGVCARYIHSHQTLYAMDDFVEAQ
                     AFLQAIIKKLDRSTVDLIKRY"
     gene            24817..25110
                     /locus_tag="VHC05_001115"
     CDS             24817..25110
                     /locus_tag="VHC05_001115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4651 domain-containing protein"
                     /protein_id="HEQ5402432.1"
                     /translation="MRDMSKKKIGMISGIFGFSLAIGLGIVIKDYCQDRQRRQMTRDL
                     RTFFSPLGQIEVLYINPCQVKQDYISGGVVMSNGKQYQFTYHSRQISFEEDKG"
     gene            25107..25424
                     /locus_tag="VHC05_001116"
     CDS             25107..25424
                     /locus_tag="VHC05_001116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin family protein"
                     /protein_id="HEQ5402433.1"
                     /translation="MIRPTSYEPLAALIEKEDKLVLFFTADWCPDCQFIYPIMPEIEA
                     ELTDMTFVCVNRDQFIEVAQKWNIFGIPSFVVIEKGQEVGRLVNKMRKTKTEIMHFLA
                     AYQ"
     gene            25442..26068
                     /locus_tag="VHC05_001117"
     CDS             25442..26068
                     /locus_tag="VHC05_001117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4479 and tRNA-binding domain-containing
                     protein"
                     /protein_id="HEQ5402434.1"
                     /translation="MIFAYNKEQVGDVLMVILQDTKDIKRQVERKGKVARVFAEESGK
                     TLAWNIFEASSLITIEGNGQIFLTDEDLARLNAELAKEGFSERLEPIVGPVFVVGQIV
                     EMVAHPDSDHLNICQVAIGEDQTVQIVAGAPNAALGLKTIVALPGAIMQNGSLIFPGK
                     LRGEESYGMMCSPRELALPNAPQKRGIIELDESAVVGEAFDPAKHWKG"
     gene            26220..26615
                     /locus_tag="VHC05_001118"
     CDS             26220..26615
                     /locus_tag="VHC05_001118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HEQ5402435.1"
                     /translation="MYNKVIAIGRLVAKPELVKTATDKHVARLSLAVNRRFKNASGER
                     EADFISVVVWGKLAETLVSYASKGSLMSIDGELRTRKYDKDGQVHYVTEVLCQSFQLL
                     ESRAQRAMRENNVTNDLVDLVLEEDTLPF"
     gene            complement(26875..27516)
                     /locus_tag="VHC05_001119"
     CDS             complement(26875..27516)
                     /locus_tag="VHC05_001119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxynucleoside kinase"
                     /protein_id="HEQ5402436.1"
                     /translation="MLIVLAGTIGAGKSSLAAALGEHLGTDVFYEAVDNNPVLDLYYQ
                     DPKKYAFLLQIYFLNKRFKSIKEAYQADNNILDRSIFEDELFLKLNYKNGNVTKTELD
                     IYQELLANMLEELEGMPKKRPDLLIYIDVSFDKMLERIEKRGRSFEQVDGNPSLEQYY
                     HQVHGEYPTWYEDYKVSPKMKIDGNSLDFVQNPQDLATVLKMIDTKLKELHLL"
     gene            complement(27536..28513)
                     /gene="dusB"
                     /locus_tag="VHC05_001120"
     CDS             complement(27536..28513)
                     /gene="dusB"
                     /locus_tag="VHC05_001120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="HEQ5402437.1"
                     /translation="MTKLNSSFRIGDVEIPHRTVLAPMAGVTNSAFRTIAKEFGAGLV
                     VMEMISEKGLLYNNEKTLHMLHIDENEHPMSIQLFGGDAEGLKRAADFIQTNTKADIV
                     DINMGCPVNKVVKNEAGAKWLRDPDKIYHIVKEVTSVLDIPLTVKMRTGWADSSLAVE
                     NALAAESAGVSALAMHGRTREQMYTGTCDHETLARVSKAITKIPFIGNGDVRSVQDAK
                     FMIEEIGVDAVMIGRAAMNNPYLFTQINHFFETGQELADLPFAKKLDIAKDHLKRLIN
                     LKGETIAVREFRGLAPHYLRGTAGAAKVRGAVSRAETLAEVEAIFETVR"
     gene            complement(28500..29372)
                     /gene="hslO"
                     /locus_tag="VHC05_001121"
     CDS             complement(28500..29372)
                     /gene="hslO"
                     /locus_tag="VHC05_001121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HEQ5402438.1"
                     /translation="MDKIIKSIAQSGAFRAYVLDSTETVALAQEKHNTLSSSTVALGR
                     TLIANQILAANQKGDSKITVKVIGDSSFGHIISVADTKGHVKGYIQNTGVDIKKTATG
                     EVLVGPFMGNGHFVTIIDYGTGNPYASTTPLITGEIGEDFAYYLTESEQTPSAIGLNV
                     LLDENDKVKVAGGFMVQVLPGASEEEIARYEKRLQEMPAISHLLASKNHVDALLEAIY
                     GDEPYKRLSEEPLSFQCDCSRERFEAALMTLPKADLQAMIDEDKGAEIVCQFCGTKYQ
                     FNESDLEALINDKA"
     gene            complement(29519..31012)
                     /gene="rofA"
                     /locus_tag="VHC05_001122"
     CDS             complement(29519..31012)
                     /gene="rofA"
                     /locus_tag="VHC05_001122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_047149466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator RofA"
                     /protein_id="HEQ5402439.1"
                     /translation="MIEKYLESSIESKCQLVVLFFKTSYLPITEVAEKTGLTFLQLNH
                     YCEELNAFFPGSLSMTIQKRMISCQFTHPFKETYLYQLYASSNVLQLLAFLIKNGSHS
                     RPLTDFARSHFLSNSSAYRMREALIPLLRNFELKLSKNKIVGEEYRIRYLIALLYSKF
                     GIKVYDLTQQDKNTIHSFLSHSSTHLKTSPWLSESFSFYDILLALSWKRHQFSVTIPQ
                     TRIFQQLKKLFVYDSLKKSSHDIIETYCQLNFSAGDLDYLYLIYITANNSFASLQWTP
                     EHTRQCCQLFEENDTFRLLLNPIITLLPNLKEQKASLVKALMFFSKSFLFNLQHFIPE
                     TNLFVSPYYKGNQKLYTSLKLIVEEWMAKLPGKRYLNHKHFHLFCHYVEQILRNIQPP
                     LVVVFVASNFINAHLLTDSFPRYFSDKSIDFHSYYLLQDNVYQIPDLKPDLVITHSQL
                     IPFVQHELTKGIAVAEISFDESILSIQELMYQVKEEKFQADLTKQLT"
BASE COUNT         9365 a         5613 c         6745 g         9462 t
ORIGIN      
        1 tatattactg ataaggtcta tttaatgcgc aagatttgtg gtatgatgaa tatgattgag
       61 tattgatgct ttatgggatt accggtaagg ttttgaaaaa ggtttgtcac tactaggtgc
      121 ttttttaact atagaaagac agttatggat tgatgtattg taactaatgt tggaggttaa
      181 tggtcgttga gttttgagat atttacactg ataatcgggt ggaaactggt cgggtatcgg
      241 gtaatggagt gtggttcttc gtttaagcaa ggagattatc gtttggtggt tcatatttgc
      301 ttgttaaatg ttagggatga gatgctgagt cagcaaggcc atgaagataa agctgactgg
      361 ctagagcctt gagatgtgac gtttggtgga agtccttttt ggtgagatgg cacagcatat
      421 agtaatatta gatcctgagg aagaattggg actttcatta ggcttgactg gggtatgacc
      481 tcactttaca attcatttcg atgatgggtt tgatgatacg tttttagttc aagactttgt
      541 agagttggag aatttggttc tttatgagga agaagtgcag gtaattcgtt gagccagtcg
      601 tgaagatatt ttaggtatga ttgatgaagg ttcgttcatt ccttatctga agtataaaat
      661 aaatttgtgc tttgagatgg ttggtcaata taaagtccat caatcttaga agtaataatt
      721 tttgaatttt ttctgaggtt tgtgtatatt tgatagtgta ctgatgtaag aagtaaggag
      781 tactatgatg gcaatcaatg agagagcttc tgcaaaaatc aagttaggcc ttgatactaa
      841 gaataagcga tgagatggtt accacgattt atcgatggtc atgatgagta ttgatctgtg
      901 tgactatgtg acggttgacc atatagatga caataagatt gtctttgcct caaactgtcc
      961 gaaaatacct attaactaag ataatgatgt ttataagata gttcagctaa tgaaacatcg
     1021 atttcaagtt aaaagaggag tttccgttta cttggaaaag cggattccta tgtgtgctgg
     1081 tatgggagga ggttctagcg atgctgttac tatcagagca ttaaatcagt tatggctcct
     1141 tactcttagc cgaaaagata tgatggatat tggtataccg attggtagtg atgtacctta
     1201 ttgcttgctt tcaggttgtg cccaagtcac tggtaaaggt gaagtggttt gtcgcatttt
     1261 ggggctgtta tcgtcttggg tggttttggt taaaccagat tttggtatct cgacttgaac
     1321 aatttttcta gatattaatt gtaaaaccat ttcaagagtg tctactactc atttggttgc
     1381 ggcgattgaa gcgggtaact ataatgatgg gatattgact gaaatgaaca atttgctgga
     1441 agatattttc attgccaagc gaccctttat tcaaaaaata aaagagaaaa cactacaagc
     1501 tggtgctgct actgttttga tgacaggaag tggaccgact gtttttgctt tgtgccaaac
     1561 cgaaaaacaa actataatag tttaaaaggc ctttgcaagg aagtttttaa ggtgagaatg
     1621 ttgtaatatt ttgttgggat tgcttctttg gaagcttcat gttataatta actggttaat
     1681 gaaagaggag atttatgggg actttagaaa aaaaacttga taacttagta aatactattt
     1741 tattaaaagc agaaaatcag catgagttat tatttggagc ttgtcaaagt gacgttaagc
     1801 ttactaatac gcaagaacat attttaatgt tactatctca gcaacgtctc actaatacag
     1861 atttggctaa ggcattaaat attagtcagg cggcagtaac taaggctatc aagagtttgg
     1921 tcaaacaaga catgctagca ggaactaagg atacggttga tgctagggtg acttattttg
     1981 aattaaccga gttagctaag cctattgcat cagaacatac ccatcatcat gatgaaacct
     2041 taaatgttta caaccgttta ttacaaaaat tctccgcgaa agaattagag attgtagata
     2101 agtttgtaac agtttttgct gaggaattag aagggtaatc catgagatat atatcagtgg
     2161 aaaatctctc ctttcaatat gaaagtgagc cagttttaga agggatcact tatcatttag
     2221 atagtggaga atttgtcacc atgaccggtg aaaatggtgc tgcaaagtca accttaataa
     2281 aagcaacctt agggatttta caaccaaagg ctggacgagt tactattgct aaaaaaaata
     2341 aagacggtaa acaattaaga attgcttact tgccgcagca agtagctagc tttaacgctg
     2401 gttttccatc caccgtttac gagtttgtca aatcaggtcg ctacccacgt agtggttggt
     2461 ttagacattt gaacaaacac gatgaagagc atgtgcaagc aagcttagaa gcagtcggca
     2521 tgtgggaaaa ccgtcataag agaattggta gtttatcagg tggtcaaaaa caacgtgtgg
     2581 ttattgcccg tatgtttgct tctgaccctg atatttttgt gctagacgag ccaacaacgg
     2641 gaatggatag cggtactact gatacctttt atgaactgat gcaccacagt gcacatcaac
     2701 atgggaaatc cgttctgatg attacccatg acccagaaga agtgaaggct tatgctgatc
     2761 ggaacattca tttagtcaga aaccaaaaac ttccttggcg ttgtttcaac attcatgaag
     2821 ttgaaacaga tgacgaaaaa ggaggtcatg gtcatgcttg atattttatc ctatgatttc
     2881 atgcaacggg cggtaatggc ggtagttgcc attagtattt ttgctccgat tttaggtatt
     2941 ttccttattt tacgtcgtca aagtttgatg agcgataccc ttagtcatgt ttctttggct
     3001 ggggtagcgc ttggggtagt ccttggtatt tcaccaacca tcactactat tattgttgtg
     3061 gttttagctg ctattttgtt agaatacctg cgtgtagttt acaaacacta catggagatt
     3121 tcaacggcga ttttgatgtc acttggcttg gccctatctc tgattattat gagtaagtcg
     3181 catagttcat caagcatgag tttagaacaa tacctttttg gatcgatcat cacgattagt
     3241 atggaacaag ttgtcgcctt gtttgctatt gctgcgatta ttttaatctt gaccgttctc
     3301 ttcattagac cgatgtacat tctgaccttt gatgaagata ctgcttttgt agatggtttg
     3361 cccgttcgct tgatgtctgt tctattcaat atcgtcactg gggttgctat tgctttaacc
     3421 attccagcag caggagcact tttggtttct accattatgg tcttgccagc aagtatcgca
     3481 atgagattgg gtaaaaactt taaaacagtt atcttactgg gaattgtcat cggttttagc
     3541 ggtatgttat ctggtatttt cttatcttat ttctttgaaa cgccagctag tgccactatt
     3601 accatgattt tcattagtat tttcctctta gttagtctag gtggaatgct taaaaaacgg
     3661 ttattttaat aagaaaaatc ctcacatgtt taatatgtga ggatttattt ataaatgctt
     3721 taaaaagggg gtaaggtccc aattttcttg attaatggtg atgccctccc aaaagctatc
     3781 attagttaaa cgaggaatca aatgaaggtg aaaatgagtc ccctcatcca tcaactcctt
     3841 gtcattgctg acgctagtga cgcctgaaat gggaaggtgc tgctctagct tagcaactag
     3901 agcggcttgt aagttgatga gatcatagcg cacttccttt ggtagttgtg tcagactagt
     3961 gtaatggtct ttggaaatca gtaaaaggtg ccccttttgg ataggatcaa tatcaaaaac
     4021 aaccttgaaa tattgacttt gagtcagtag ctgatttgct ttgagctgat ggcaaaagat
     4081 acattctgtc ataggtacat ctccttatga aaaaacgagc cagagctcgt ttaatcggtt
     4141 atctagtaag tgagaacagc gtattttttc ttaccgcggc gaataacggt taattgatca
     4201 tcaattttat catcattact taattggtaa tctaaatctt gaacgcggtc tccgttaatg
     4261 tagattgctc cattttgcac gtcttcacgc gcctggcgtt ttgatgggga aatcttagca
     4321 gctactaaaa tctcgacaat attatgattg tctattgatt gaacgtgata atttggtaca
     4381 ttgctcaatc cttgttttaa ttcattagca gaaagatttt tgatgtttcc agcaaataac
     4441 tgctcggtaa tgttaagagc ttgtttataa gcttcttcgc catgaaccaa ggtaaccact
     4501 tcgcgtgcca aggttttttg agcgagacgc tcgtgacgag cggcattaaa ttgagtttca
     4561 atttctgcaa tctcatctag agataagaag gtgaagattt tcaagaaacg cactgcatca
     4621 tcatccatga catttaacca gaattggtac atctcgtaag gagacgtctt atcggcatca
     4681 agccagacgg cattaccttc tgatttaccg aattttttcc cggttgagtc agtgatgagt
     4741 ggtacagtca tgacgtgccc agttttatca gcctttttgc ggagcaattc agtaccagct
     4801 gtcatattac cccactggtc agagccgcca atttgtaagg ttacattatg cttgtcattg
     4861 agttcgtaga agtcgtagcc ctgcatgatt tggtaagcaa actcagtgta agaaatgcct
     4921 gtttcaatgc gttttttaac agagtcttta ctcatcatgt agttaacggt gaagtattta
     4981 ccgacatcac ggaggaagtc aataaagctg atttgcgaga accagtcgta gttgttgaca
     5041 agctctgctt tattatcacc attttcaaaa tcaaggaaag tagacaactg ccctttaatc
     5101 ttgtcactcc actccaaaac tgtttctttg gtttgaaggc tgcgctctgc atctttaaag
     5161 gaaggatcac caattaaacc tgtggcacca cccacaagag cgtaaggttt gtgccctgct
     5221 agttgcaagc gacgagatgt taagatagcc actagatggc ccagatgaag gctgtcagcg
     5281 gttggatcat aaccggtata ataggatact tgcccttctg ttaatgcttt gacaagggct
     5341 tgttcatcag tcgtttgaaa gaccaagcca cgagctttga gttcttcaaa aatattcata
     5401 ggctttctcc attttcatta tagtttcgaa tcattatatc aaaaaacgct actgctatgc
     5461 aagctttatc aaagtttggt ataatgataa atgaggtatt ttatggtgaa atggaacacg
     5521 aaacaaaagc gtataagtca tcaaagatta ggtctcttgg atttggggcc ggtgctatta
     5581 cgtacgttga gactactgtc taactttttt tatattgtta tcttcctttt tggaatgatg
     5641 ggatttggta tggcatttgg gtatttggct agtcagattg aatctgttaa ggtaccaagt
     5701 aaagaaagtt tagtcaaaca agttgaatca ttaacgatga tttcgcaaat gaactattct
     5761 gataatagtt taatttctac tttagatacg gatttacttc gaacaccagt agctaatgat
     5821 gcgatttcag agaatatcaa aaaagctatt gtatcaacag aagacgaaca ttttcaagaa
     5881 cataaaggta tcgtgccaaa agctgttttt cgggcaacat tggcttctgt attgggattt
     5941 ggagaagcta gtggaggttc gaccttaaca cagcaattag tcaagcaaca agttttggga
     6001 gacgatccca catttaagcg caagtctaag gagatcgttt acgctcttgc cttagagcgt
     6061 tatatgtcca aagacaatat cttatgtgat tatcttaatg tttcaccttt tggccgtaac
     6121 aacaagggtc aaaatattgc tggtgttgaa gaagctgcgc gtggcatttt tggagtttct
     6181 gccaaagatt taacggtgcc acaggcagca tttttggcgg ggcttccgca gagtcctatt
     6241 gtttactctc cttatttgtc aacgggacaa ctgaagtcag aaaaggacat ggcttatggc
     6301 atcaagcgtc agcaaaatgt tctctataac atgtaccgta caggtgttct gtctaaaaaa
     6361 gaatacgagg actataaggc ttatccgatt caaaaggatt ttattcaacc gggaagcgca
     6421 atagtaaata atcacgatta cctttattac acggtgttag cagatgctaa aaaagccatg
     6481 tatagctatt tgattaagcg agataaggtg tctagtcgtg acttgaaaaa tgacgatact
     6541 aaggctgctt atgaagagag agccttaaca gaattgcaac agggtggcta taccatcacc
     6601 acaaccatta ataagcctat ttacaatgcg atgcagacag cggcagctca gtttggtgac
     6661 ctgttagatg atggcactgg tacagttcaa atgggaaatg tcttgacaga caatgcgact
     6721 ggtgctgtgt taggttttgt tggtggtaga gattatgctc tgaatcaaaa taatcatgct
     6781 ttcaatacag ttagatcgcc aggttctagc attaaaccga taatcgctta tggtcctgct
     6841 attgatcaag gtttaatggg gagtgctagc gttttgtcta attacccaac aacttactcg
     6901 agtggccaaa aaatcatgca tgctgatagt gaaggaacag ccatgatgcc acttcaagag
     6961 gccctaaata cttcttggaa catcccagct ttttggacac agaaattact gcgtgaaaaa
     7021 ggggtcgatg tcgaaaatta tatgacaaaa atgggttata agattgcaga ctactcgatt
     7081 gaaagtttac ctctaggggg cggtattgaa gtctcggttg ctcaacaaac caatgcttac
     7141 caaatgcttt caaacaatgg cttatatcaa aagcaatata ttgtagataa gattactgct
     7201 agcgatggta cagtcgttta caaacatgaa aataagccaa ttcgtatttt ttctgcagca
     7261 acagctacga ttttacaaga attgttgaga ggtccgatta cttcaggcgc tacgactact
     7321 ttcaagaacc gtttggcggc tattaatccg tggcttgcta atgctgattg gattggtaag
     7381 accggaacaa ctgagaatta tacggatgtt tggctagtcc tgtctactcc aaaagttacc
     7441 ttaggcggtt gggcaggaca tgatgacaat acctcattag cgccattaac aggatataac
     7501 aataattcta attaccttgc ctatttagct aatgccatta atcaggccga tcccaatgtt
     7561 attggagtag ggcaacgctt caacttagat ccaggagtca ttaaggcgaa tgtcttgaag
     7621 tcaacaggtt tacaaccagg aactgttaat gtcaatggac atactttttc tgttggtgga
     7681 gaaatgacca ccagtctatg gtcccaaaaa ggaccggggg ctatgactta ccgatttgct
     7741 attggtggca cggatgccga ttatcaaaaa gcctggggga actttgggtt cagaaaaaat
     7801 taggttgcca tttatcgata aaaagggtat aatagcaata actatttgtc gtccaatcta
     7861 gctgaaatat tgtccagtta ggaagaacag cagttaaatc acactgataa agtcagattt
     7921 agctgctctt tttgtgtcta tttttagaaa agatagggtt tgtaacctat atttaaatat
     7981 tctaaaaatt aacatttagg gcaaatgata acttagttgc gatttgctga aacagcaaag
     8041 cttaaataga agaaggagct aaaaacttgg caggacatga agttcgatac ggaaaacacc
     8101 gtacacgtcg tagcttttca agaatcaaag aagttcttga tttaccaaat ttgattgaaa
     8161 ttcaaactga ctcattccaa gatttcctcg attcaggttt gaaagaagta tttgaagatg
     8221 tacttcctat ttcaaacttt acggatacta tggaacttga atttgttggt tacgaattta
     8281 aagaacctaa atataccctt gaagaagctc gtatccacga tgcaagttat tctgcaccaa
     8341 tctttgttac cttccgtttg gtcaataaag aaactggtga gattaaaact caagaagtct
     8401 tctttggtga tttcccaatc atgacggaaa tgggtacctt tattatcaat ggtggtgaac
     8461 gtatcatcgt ttctcagttg gtgcgttctc caggtgttta tttcaacgat aaagttgata
     8521 aaaacggtaa agttggttac ggatcaacag tgattcctaa ccgtggggct tggttggaat
     8581 tagagactga ctcaaaagac attgcctaca ctcgtattga ccgtacccgt aagattccat
     8641 tcacaacctt ggttcgtgcc cttggtttct caggtgatga tgaaattgtt gatatctttg
     8701 gtgaaagcga ccttgttcgt aataccattg aaaaagacat tcacaaaaat ccaagtgatt
     8761 ctcgtacaga cgaagccctt aaagaaattt acgagcgtct tcgtccaggt gagccaaaaa
     8821 ctgcagatag ctctcgtagt cttttgattg cgcgtttctt tgatgcacgt cgttacgatt
     8881 tggctgcggt tggtcgttac aaagtgaaca aaaaacttaa tatcaagact cgtcttttga
     8941 accaaatcat tgctgaaaac cttgtggatg ctgaaactgg cgaaattttg gtagaagctg
     9001 gaactgagat gactcgtagc gtcatcgaat ccatcgaaga acaccttgac ggtgatttga
     9061 acaagtttgt ttacacacca aatgattacg ctgttgttac tgaaccagtt gttcttcaaa
     9121 aattcaaggt tgtgtcacca attgatcctg accgcgtggt aactattgtt ggtaatgcca
     9181 atccagatga caaggttcgt gcattgacac ctgctgatat tttggcagaa atgtcttact
     9241 tcttgaacct tgctgaaggt cttggaaaag ttgacgatat tgaccacttg ggtaaccgtc
     9301 gtatccgtgc cgttggtgaa ttgcttgcca accaattccg catcggtctt gctcgtatgg
     9361 agcgtaacgt gcgtgagcgt atgtctgttc aagacaacga tgtgttaaca ccacaacaaa
     9421 tcatcaatat ccgtcctgtc acagcagctg tcaaagaatt cttcggttcg tctcagttgt
     9481 cacagttcat ggaccaacac aacccattgt cagagttgtc tcacaaacgt cgtttatctg
     9541 ccttaggacc tggtggtttg acacgtgacc gtgctggtta tgaggttcgt gacgtgcatt
     9601 acacgcacta tggccgtatg tgtccgattg aaacacctga aggaccaaac attggattga
     9661 ttaacaactt gtcttcattt ggacatctta ataaatatgg tttcattcaa acaccttacc
     9721 gtaaggttga ccgtgcgact ggtagggtaa ctaacgagat tgtttggttg actgccgacg
     9781 aagaagacga atacacagtt gcacaggcca attcgaaact aaacgaagat ggcacttttg
     9841 ctgaagaaat cgttatgggt cgtcaccaag gtaataacca agaattttct gcaagtgttg
     9901 ttgatttcgt tgatgtttcc cctaaacagg tagttgctgt tgcgacggca tgtattcctt
     9961 tcttggaaaa cgatgactcc aaccgtgccc tcatgggtgc caacatgcaa cgtcaggctg
    10021 tgccattgat tgatccaaaa gcaccatatg ttggtactgg tatggaatat caagctgccc
    10081 atgactcagg cgctgcggtg attgctcagc acaatggtaa agttgtcttt tctgatgctg
    10141 aaaaagtgga aatccgtcgt caagatggct cacttgatgt ttaccacatt accaaattcc
    10201 gtcgttcaaa ctcaggaaca gcctataacc aacgcaccct tgttaaagta ggagacatcg
    10261 ttgaaaaagg tgacttcatc gctgatggac catctatgga aaacggtgaa atggctcttg
    10321 gacaaaaccc agtcgttgct tacatgactt gggaaggtta taactttgag gatgccgtta
    10381 tcatgagtga gcgccttgtg aaagaagatg tctacacatc tgttcacttg gaagaattcg
    10441 aatctgaaac gcgtgataca aaacttggcc ctgaagaaat cactcgggaa atcccaaatg
    10501 ttggtgaaga agccctcaaa gaccttgacg aaatgggcat tatccgtatc ggtgctgagg
    10561 ttaaagaagg cgacatctta gtaggtaaag tcacacctaa aggtgaaaaa gacctttctg
    10621 ctgaagaacg tttacttcac gccatctttg gggataaatc gcgtgaagtg cgtgatacct
    10681 cacttcgtgt ccctcatggt ggtgatggta ttgttcgtga tgtgaaaatc tttacacgcg
    10741 ctaacggcga tgaattgcaa tcaggtgtta atatgcttgt gcgtgtttac atcgctcaaa
    10801 aacgtaaaat caaggtcgga gataaaatgg ccggtcgtca cggaaacaag ggtgtcgttt
    10861 cacgtattgt accagttgaa gacatgccat accttccaga cggaacacca gttgacatca
    10921 tgttgaaccc tctcggggtg ccatcacgga tgaatattgg tcaggttatg gaacttcacc
    10981 ttggtatggc tgctcgtaat cttggcattc acattgcaac acctgtcttt gacggggctt
    11041 catcagaaga cctttgggac actgttcgtg aagctggcat ggatagcgat gctaagacgg
    11101 tcctttatga tggtcgcacc ggtgaaccat ttgacaaccg tgtatccgtt ggtgtcatgt
    11161 atatgatcaa acttcaccac atggttgatg ataaacttca tgcccgttct gtaggaccat
    11221 actcacttgt tacccaacag ccacttggtg gtaaagctca atttggtgga caacgttttg
    11281 gtgagatgga ggtttgggcc cttgaagctt atggtgcatc aaatgttctt caagaaatct
    11341 tgacctacaa gtcagatgac gtcacaggac gtttgaaagc ctatgaagcg attactaaag
    11401 gtaaaccaat tccaaaacca ggtgtaccag aatccttccg tgttcttgta aaagaattgc
    11461 aatcgcttgg tcttgatatg cgtgtgcttg acgaggatga taatgaagtg gaacttcgtg
    11521 atcttgatga aggtgaagac gatgatatta tgcatgttga cgatctcgag aaggcacgtg
    11581 aaaaacaagc tcaagaaacc caagaagttt ctgaaacaac tgacgaaaaa taagcaatca
    11641 attcttatta aataattatt tactggtctg gggcaaaggc cccaggaact ggtaaagtca
    11701 tcaaaggcag aaaggtaaaa ctagtggttg acgtaaatcg ttttaaaagt atgcaaatca
    11761 cattagcctc accaagtaag gtccgttcat ggtcttatgg tgaagttaaa aaacctgaaa
    11821 caatcaacta ccgtacatta aaaccagaac gtgaaggact ctttgacgaa gtcatctttg
    11881 gtccaacaaa agactgggaa tgtgcgtgtg gtaagtacaa acgtatccgt tataaaggga
    11941 tcgtttgtga ccgctgtggg gttgaggtaa ctcgtgctaa agtacgtcgt gaacgtatgg
    12001 gtcacattga gttaaaagct cctgtatcac atatctggta tttcaaaggg attccatctc
    12061 gtatgggatt gactcttgat atgagtcctc gtgcccttga agaagtgatc tattttgcgg
    12121 cttatgtggt cattgatcca aaagatacac cgcttgaacc aaaatcatta ttaacagaac
    12181 gtgaataccg tgaaaaacta caagagtatg gtcatgggtc atttgtcgct aagatgggtg
    12241 ctgaagccat tcaagatctc ttgaaacgtg tggacttggc agctgaaatc gctgaattaa
    12301 aagaagagtt gaaatctgct tctggtcaaa aacggattaa agcagttcgt cgtttagacg
    12361 tccttgatgc ctttaacaaa tctggaaata aaccagaatg gatggttctt aacatcctgc
    12421 cggttattcc accagatctt cgtccgatgg ttcaattgga tggtggtcgt tttgcggcat
    12481 cagacttgaa tgacttgtac cgtcgtgtga ttaaccgtaa caaccgtttg gcacgtttgt
    12541 tagaacttaa tgcccctggc atcattgttc aaaatgaaaa acgaatgctt caagaagccg
    12601 ttgatgcttt gattgataat ggtcgtcgtg gtcgtccaat cactggacca ggaagtcgtc
    12661 cattgaaatc attgagccac atgcttaaag gtaaacaagg gcgtttccgt caaaacttac
    12721 ttggtaaacg agtagacttc tctggacgtt ccgttatcgc tgttggtcca acccttaaaa
    12781 tgtatcaatg tggtgtccca cgtgaaatgg ctatcgagct ttttaaacca tttgtaatgc
    12841 gcgaaattgt tgccaaagaa tatgctggta acgttaaagc cgctaaacgt atggttgaac
    12901 gtggcgacga acgcatctgg gatatcttag aagaagttat caaagaacac ccagtcctac
    12961 ttaaccgcgc accgaccctt cacagacttg gtattcaggc ttttgaaccg gttcttattg
    13021 acggtaaggc acttcgtctt cacccacttg tgtgtgaggc ctacaatgcc gacttcgatg
    13081 gagaccaaat ggccatccac gtgccacttt cagaagaagc acaagctgaa gctcgtcttt
    13141 tgatgcttgc tgcagagcac atcttgaacc ctaaagatgg taaaccagtt gttaccccat
    13201 ctcaggatat ggttcttggt aactactatc ttacgatgga agatgctggt cgcgaaggcg
    13261 aaggtatgat tttcaaggat aaagacgaag ctgtgatggc atatcgtaat ggctatgctc
    13321 atcttcatag tcgtgtgggt atcgctgttg acagcatgcc aaacaaacct tggaaagaca
    13381 gtcaaagaca taaaatcatg gtgacaactg ttggtaagat tctctttaac gacatcatgc
    13441 cagaggacct tccttacctc caagagccaa acaatgccaa cttgacagaa ggaacacctg
    13501 ataaatactt ccttgaacct ggtcaagata tccaagaagt gattgacggc ttagaaatca
    13561 atgtgccatt caagaagaaa aacctcggta acatcattgc ggaaaccttc aaacgtttcc
    13621 gtacaacaga aacatcagcc ttccttgacc gtttgaaaga ccttggttac taccattcaa
    13681 cccttgctgg tttgacagtg ggtatcgctg acattcctgt tattgataat aaagctgaaa
    13741 tcattgatgc tgctcaccat cgtgttgaag aaattaacaa agccttccgt cgtggtttga
    13801 tgacagatga tgaccgttat gttgccgtta caacaacatg gcgtgaagct aaagaagccc
    13861 ttgaaaaacg tctgattgaa acacaagatc ctaagaaccc aatcgttatg atgatggact
    13921 caggagctcg tggtaacatc tctaacttct cacagcttgc gggtatgcgt ggtttgatgg
    13981 ctgctcctaa cggacgcatc atggaacttc ctatcttgtc aaacttccgt gaaggtttga
    14041 gcgttttgga aatgttcttc tcaacccacg gtgcacgtaa agggatgacc gatacggccc
    14101 ttaaaacagc cgactcaggt tatcttactc gtcgtttggt tgacgttgcc caagatgtta
    14161 tcattcgtga ggacgattgt ggcactgatc gtggtcttct tatccgtgct attacagatg
    14221 gtaaagaagt taccgaaacg cttgaagagc gtcttcaagg tcgttacaca cgtaaatcag
    14281 tcaaacaccc tgaaactggt gaagtcttga ttggtgctga ccaattaatc actgaagaca
    14341 tggctcgtaa gattgttgat gcgggtgttg aagaagtgac cattcgttct gtctttacct
    14401 gtgcgactcg tcatggtgtc tgccgtcact gttatggtat caaccttgca actggtgatg
    14461 ctgttgaagt gggtgaagca gttggtacta ttgctgccca atctatcggt gagcctggta
    14521 ctcagcttac catgcgtacc ttccacacgg gtggtgtagc ctcaaatacc gatatcacac
    14581 agggtcttcc tcgtattcaa gagatctttg aagcacgtaa tcctaaaggg gaagcggtca
    14641 ttactgaagt gaaagggaat gtcgtcgaga ttgaagaaga tgcgtcaact cgtaccaaga
    14701 aagtctacgt tcaaggtaaa actggcatgg gcgaatatgt cgtaccattt acagcacgta
    14761 tgaaagttga agttggcgac gaagttaatc gcggagctgc tcttacagaa gggtcaattc
    14821 aaccgaaacg tctccttgaa gtgcgtgata ccttgtcagt tgaaacgtac cttcttgcag
    14881 aagtacaaaa agtttaccgt agccaagggg tagaaatcgg agacaaacac gttgaggtaa
    14941 tggttcgcca aatgcttcgt aaagttcgtg tcatggatcc aggtgataca gacctccttc
    15001 caggtacact tatggatatt tctgatttca cagatgctaa caaagatatt gttatctctg
    15061 gtggtatccc tgcgacatct cgtccagttc ttatgggtat tactaaggct tcccttgaaa
    15121 ccaattcctt cttatcagct gcatccttcc aagaaacaac tcgtgttctt acagatgctg
    15181 ctatccgtgg taagaaagac cacttacttg gtcttaaaga aaatgttatc attggtaaaa
    15241 tcattccagc tggtactggt atggcgcgct accgtaacat tgaaccacaa gcgatgaatg
    15301 agattgaagt gattgatcat acagaagtct cagcagaagc cgtttttaca gcagaagcag
    15361 aataatctca tgaaagagtc cttaggggct cttttttgtc tgagtttgtt ggcagtaaaa
    15421 agcattgaca atcagtctta gtcccaatga gcagatgttt ttcaaaatac ttatgattta
    15481 gctataataa tgcataagag gaataggtaa tgtgttatgt atcaagtaat taaaatgtat
    15541 ggtgattggg agccttggtg gttcatcgat ggatggcaag acgatattat agatgagcaa
    15601 caatttagtg actggcaaga agcgcttgat tattttaatc aagaatggca gcgcatgaaa
    15661 gctatttttc ctagttatca tagtcaaaag aatttgttag ctactttttg ggaaaaagaa
    15721 gataaaagat ggtgcgagga ctgtgacgaa gatttacagc agtttcattc tcttttactc
    15781 cttaaaaata aagatattgt accaagcaat aattatatcc ctgaatttga acaacgaaat
    15841 gattcaccac aggtagctta tctttgcaag ttaaaccttt aagtgtttgt taaaaacaaa
    15901 ataagttaaa agaaaatatc acttcttatg atattttctt tttttgttta cgaataaatg
    15961 agtaaggagg aattatggta caagcattag caaaagctat tctagcaaaa gctgaacagg
    16021 ttcaggcaca agatatttat attttgccaa gagcagatca atatgatctt tttttacgaa
    16081 taggagatga aaggagatta gttgatgttt atcagagcga tcggatggct cctcttatta
    16141 gtcactttaa attcgttgca ggaatgatag ttggtgaaaa gagacgttgt caggtgggtt
    16201 catgtgatta taagcttagt aaagataagc agttatcttt gcgcttatct agcgtgggtg
    16261 attatcgcgg gcaagaaagc ttagtgattc gtctgcttca tcatcaaaat aaaagtgtac
    16321 attattggtt tgatggattg acaaaagtag ccaatcaagt tggcggtaga gggttgtatt
    16381 tatttgcagg accagttggg tctgggaaga caaccttgat gtaccagctg atttcgagtt
    16441 atcatcaaga agcacaggtt attagtatag aagatcctgt agaaattaaa aatcaccaaa
    16501 ttttacaatt acaagtgaat gatgatattg gtatgactta tgacaatttg atcaaactgt
    16561 ctttacgcca tcgaccagat attttagtta ttggtgagat tcgagatagt caaacagcaa
    16621 gagccgttat tagggctagt ctaacaggtg ccatggtttt ttcaacggtt cacgctaaaa
    16681 gtatctcggg tgtttatgca agattgttag aacttggtat aacgaaagca gaactgtcta
    16741 attgcttagc attaattgct taccaaaggt tacttaatgg aggagcattg attgactcta
    16801 ctcaaaacga atttgaatat tattcctcat cgaactggaa tcaacaaatt gatcagcttc
    16861 ttgaggcagg acatctcaat cccaagcaag ctaagcttga aaaaattatc tagtaaacat
    16921 cagcataaat tcattcaatt actagctaat cttttatcta caggatttag cttcgcagag
    16981 gttattgctt ttttaaaaag aagccagttg cttcagctag attatgttct taaaatggaa
    17041 gagtctttat taaaaggaca aggcttagca gatatgttgt cgggtttagg tttttcagat
    17101 gctattctta ctcaaattag tttagctgat agacacggta atattgaaac aacattagta
    17161 gcgattcaac attacttgaa ccaaatggca aggatcagac gaaaaactgt tgaagttatc
    17221 acctatcctc ttattctttt actttttctt tttgtgatga tgctagggtt gagacgttat
    17281 ttagtccctc aattagaaac tcaaaatcag ataacttact ttcttaacca ttttcctgcc
    17341 ttctttatag gtttttgctc aggtcttatt ttgttgttcg ggatggtatg gctacgatgg
    17401 cgatctcaaa gccgcttgaa actctatagt cggctaagcc gttatccttt tttaggtaaa
    17461 ctgttaaaac aatacttaac tagttattat gctagagaat ggggtacgtt aataggtcaa
    17521 ggtcttgatt tgatgactat tttagacatt atggccattg agaaatcctc actaatgaaa
    17581 gaattagctg aggacatcag aatgagtctg cttgaagggc aagcctttca cattaaagta
    17641 gctacctacc ctttttttaa aaaagaatta agtttaatga ttgaatacgg tgaaatcaaa
    17701 tcgaaactgg gggctgagtt ggaaatctat gcccaggaaa gctgggaaca attttttagt
    17761 cagctttatc aagtgacaca acttattcaa ccagctattt ttttagtagt tgctgtgaca
    17821 atcgtcatga tttatgcggc aatcctatta ccaatttacc aaaatatggg aggtattttt
    17881 taagatgatt aatcaatgga acaacttacg acacaagaat ctaaaaggat ttactcttct
    17941 agaaatgtta ttggtgattc ttgttatcag tgttttgatg ctattatttg tgcctaattt
    18001 aagcaagcaa aaagacaggg ttacagaaac aggtaatgcc gctgttgtta aattagtgga
    18061 gaatcaagca gaactatatg aattatctca aggctcaaaa ccaagtttga gccagttaaa
    18121 ggcagatggt agtatcactg agaaacaaga aaaagcttat caagactatt atgacaaaca
    18181 taaaaatgaa aaagcccgtc ttagcaatta aagcttttac tttgcttgaa actttactaa
    18241 gtttgtcagt gatgagtttc attatattgg gattgtctgt accagtgaca aaaagctatc
    18301 aaaaagtaga agagcatctg ttttttagcc attttgaaca tttgtatcga catcagcaaa
    18361 agttagccat attacagcaa aaacagcgcg tcttggatat ttcttcaaca aaaattgtta
    18421 cagaaggtaa tagcctaaca gttcctaaat caataacagt gaatcatcct tatcggttag
    18481 ttattgatca gatgggaggc aaccattcct tagctaaaat tatttttgac atgactgatc
    18541 gacgctttaa ataccaattt tatctaggga gtgggaatta tcaaaaaaca agtcaaagct
    18601 tacatagccc ttgaaagtat gatcgcaaca ggcatcctct ttagtattgt cattctcatc
    18661 ttaagcagtt tacagcagag tcaggctgct ctaacgtact atcgaaagca gcaagaaaag
    18721 cttaatctag ccttgatggc agtacaaact agaactaaag agatgacatt gaatggttgt
    18781 catattacta ttttacgtac ggatagatat attagtattc acgatgacga aggagaagtg
    18841 atgaagattg agtaaacaat taagtaacat aaaagctttt acccttctag aggcgttaat
    18901 agccttactc gtgatatcag ggtctttatt ggtttatcaa ggtttgaccc aaaccctcct
    18961 taaacgtagc cattatctag cccgtcatga tcaagacaat tggctcttat tttctcatca
    19021 attgcgagag gagttaagtg gagcaagatt ttacaaagta gctgataata aactatacgt
    19081 tgaaaaggga aagaaagtac tagcttttgg ccaatttaaa agtcatgatt ttcgaaaatc
    19141 agctagtaat ggaaaagggt atcaacccat gttatttgga atatcacgta gtcatattca
    19201 catagagcag tcacagattt gcattacttt aaagtggaaa agtgggttag aaaggacttt
    19261 ttattatgcc tttcaagact aatctcaaag caggcatcct tttgtatgct atgtttatgg
    19321 ctagtatttt tttgctggtt ttacaggttt acctttctca agtgacagct ctacacaagg
    19381 aataccaagc tcaaactgac tatgttaaag cccgactgat agcagaaata gtttatcaag
    19441 atcatagata taaagcttct aatcctgtct tttttaaagg tggtcaagtc atttgtcgag
    19501 agcgaaaaga gagatggatg ttaattgtta agttagacca gcaacgacag tatcagtttg
    19561 aataccttaa acccaaacaa tatagtcaat aaatagtatt gttgtcataa atccttaaaa
    19621 tgatccaata tatagtaatt aaaggtgaca cttcttttca tttcaagtgt aatttggtat
    19681 gataaggtta tgacttttga aaaaattgaa gaagcttatc agctgctctt agagaactgt
    19741 caactaattg aaaatgatct aaaaacacat atatacgatg ccattgttga acaaaactcc
    19801 ttttatttag gggctgaggg agctagtcct caagttgctc aaaatagtga taaactgaaa
    19861 gccttgtgcc tgacaaaaga agaatggcgt aaggcctacc agtttctttt tattaaggca
    19921 gctcagacgg agcaactcca agccaaccat cagttcacac cagatgctat tggcttcatt
    19981 ctgctgtatc ttttggaaca attgagtgat aaagatagct tagaggtact tgagattgga
    20041 agtggaacag ggaacctagc ccaaaccctt ctcaacaaca cgagcaagag ccttgattat
    20101 gtagggattg aacttgatga tctcttgatt gatctgtcag ccagtattgc tgagataatg
    20161 gattcttcag ctcattttat tcaagaagat gcggtaaggc ctcaattact aaaagaaagt
    20221 gacattgtca tcagtgactt accagttggt tattatccta acgatgatat tgctaaacgg
    20281 tacaaggtgg ctagttcaga taagcatacc tatgcccatc atttattaat ggaacagtct
    20341 ttaaaatacc tgaaaaaaga cggttttgcg atttttctgg taccagtcaa tttattgaca
    20401 agccctcaga gccagttatt gaaacagtgg ttaaaagatt atgctcaggt ggtgaccttg
    20461 attacgctac cagattctat ttttggtcat ccctcaaatg ccaagtccat tattgtctta
    20521 caaaaacaaa cagaccaccc aatggaaacc tttgtctatc caattcggga tttgaagctt
    20581 gcagagaata ttcatgattt tatggaaaat ttcaaaaaat ggaaactgag taatgtcaat
    20641 taattgattt tttgttataa taaaaaaaca tcacagaaaa cgatttcaag agaggttaaa
    20701 aatgtcaaag acaattgcaa ttaatgcagg tagttctagt ttaaaatggc aactttatca
    20761 gatgccagaa gaagcagtgt tagcacaagg aattattgag cgtatcggtc tcaaggattc
    20821 tatttcaaca gttaagtacg atggcaaaaa agaagaacaa attcttgata ttcacgatca
    20881 tacagaagct gttaaaatct tattgaacga tttgattcac tttggaatca ttgcagctta
    20941 tgatgaaatt acaggagttg gacaccgtgt tgttgctggt ggtgaacttt tcaaagaatc
    21001 cgttgtggtt aatgataaag ttcttgaaca gattgaagaa ttatccgttt tagctccact
    21061 tcacaatcct ggagcggcgg cagggattcg tgccttccgt gatattttgc cagatattac
    21121 cagtgtttgt gtgtttgaca cgtcatttca caccagcatg gcaaagcata cttaccttta
    21181 cccaattcct caaaaatatt atacggacta caaggttcgt aaatatgggg cgcatgggac
    21241 aagtcataaa tatgtggcgc aagaagctgc taaaatgctt ggtcgtccat tagaagaatt
    21301 gaaattaatc actgctcaca tcggaaacgg tgtgtcaatt acggctaact atcatggtca
    21361 atcagctgat acttcgatgg gctttacacc acttgctggt cctatgatgg gaacacgttc
    21421 tggtgacatt gacccagcta ttattcctta tttaattgag caagacccag aattaaaaga
    21481 tgctgctgat gttgtgaata tgttaaataa gaaatcaggt cttagtgggg tgtcaggcat
    21541 ttctagtgat atgcgtgata tcgaggctgg tttacaagaa gataatccag atgctgtttt
    21601 agcttacaat atctttattg atcgcattaa aaaatgcatt ggtcaatact ttgctgtttt
    21661 gaatggggca gatgctttgg tctttacagc tggtatgggt gagaatgcac cattgatgcg
    21721 tcaagacgtt attggtggct taacgtggtt cggaatggac attgatcctg agaaaaatgt
    21781 ttttggatac cgtggtgata tttcaacacc tgagtcaaaa gtgaaggttc ttgttatctc
    21841 aacagacgaa gaattgtgca tcgcgcgtga cgttgagcgt ttgaaaaata caaaataaaa
    21901 gaggctaagt ctcaatagat taaccaagta aggtaacact ttacttggtt ttttatgagg
    21961 tttatctgtt ggttatggtg cctaggtatt agttctgatc agtctccttg ctttttgtaa
    22021 tcttgtgcta ggcgatttgg atgtcagcct tatttagaag tttttaattg cttcaacgct
    22081 tttcttgtat gtgtttatag agtccaatga tctaaaagac tatttgataa cggtttatga
    22141 tgagcgtaat cgtgcgattc gaaaacagac acaagtttac tgcttttacc tgatgattgt
    22201 tctatttgtt gccttgttct ttttcttccc ttgcttaacc attcgagacc ttgtttctta
    22261 taagctacct ttgatttttg cttaccttta cttgattatc agaagtctgg tggctaagaa
    22321 aatggaggca ctagggaaaa taacaactaa tagtcaaaag cctccgtttg atacgagtca
    22381 ggttctttgt tagatgactt gtctaacggt tgagtttcct gtctggtcaa cggaggtgtt
    22441 tgtattgttg tctgatttgt attggggcac ttattttaca agcttttagc cttatcgatg
    22501 gttttgtcaa tggcagagct gacagtagtt gtgaggccaa ggcgttctaa ctccatcaga
    22561 ccagcaatag ttgtgccacc ggggctacaa atagcgtcaa tgaaatcgtg cggactttga
    22621 gaactggtct tgagattgct ggcactagcc aagactgttt gagtaacaat ctccagcgcc
    22681 tttgctttag gcatgccatt cttgacgcca gccttagcca aagcctcaat aaagagataa
    22741 atataggcag gacttgaccc tgctaaagcg gtaaaggtgt caaaatcctt ttcactaata
    22801 tcaaatgtgc taccaaagct atctgttaag tctcgaacac gtgcttgtaa ttcctgggac
    22861 accaaagcat ttcccgttaa agcggtactg ctttggagaa tttgtgcatt catgtttggc
    22921 atgatacgca gcagcggaag gtcttgtcct acgaatgttg ctagtcgttg aagggaaatg
    22981 cctgctgcca tagatataat aggctgtttg aagtgaagcg gtttgagtac cgtttcaaat
    23041 agttgaggct tgatgcctaa aataacaaga tcaacctggt caataaggtc ttggtgggac
    23101 atagcataag gcagtgttaa ctgctccgca atttccttgg accgttctaa agatgatcct
    23161 gaaatgataa gttcatgggg tgtttgttta aggcctttga tgatagcgct agccattttg
    23221 ccaacaccaa taatgccaat tttcattctg ttgctccttt tggaatatta tggttaatca
    23281 ggctaacgct agtttagtaa cgtttaatca agtcaacggt tgagcgatcc agttttttga
    23341 taatggcttg taagaaggct tgggcttcta cgaaatcatc catagcgtag agggtttgat
    23401 gagagtgaat gtagcgtgca cagactccga tagttgttga tgggacacca tcattttgaa
    23461 ggtgtgcagc acctgcatct gtgcctccct ttccacaata gtattggaaa ttgacaccag
    23521 cgtcctcagc agtagtcagt aagaagtcgc gcatatcttt gagcatgaca tggcctgggt
    23581 cgtagaaacg caacaaggtg ccatctccga ttgttccagg attgccataa atatcaccag
    23641 caggcgaaca atctactgcg aaaaagagtt cagggtcgaa cttggtggtt gagacgtggg
    23701 ctccgcgcag accaacttct tcttgaacgt tagcacctgc aattagggtg ttgttaaggt
    23761 cttgtccttt taacgcttca agcatttctg ttatcatgag aacgccatag cgattgtccc
    23821 aagcttttga aataatattt ttttgattgg ctgttaggat cgtttcagat tgagggacaa
    23881 taatatcacc cggtgtaatg ccaaagcttt cagcttctgc cttatccgta aagccaccat
    23941 caaacacaat attttcgata tttggtagac tagcagagcc atttgcccca cgtaaaaaat
    24001 ggggaggtac cgatcctgaa ataaggggaa taacttggcc agtgcgtgtg taaagggtaa
    24061 accgttgtga actgacaaca agtgggttcc aaccaccgat accaaccacg cgtagcgttc
    24121 cgtcaacttt gatatcactg accataaaac cgacttcgtc catgtgcgca gctactaaaa
    24181 tacggggggc tttttcagct ttactatctc tgataccaaa aatgccacca agcccgtctg
    24241 tttcaacacg gtcaaccagc ggggttattt tggtgcgtag gtagtcacga acgctatgtt
    24301 catagcccgc aatgccatcc agttcggtaa cttctttgat ttttgagaat aagtctgtca
    24361 tttttcatct ccatttacaa ggtttcagac cagttcaacg cggtcatctc cctatattct
    24421 accacttttt aagtaagaat gggtttcaca gcaaagaaaa atcccagaga ctagagatct
    24481 ctggaagaag tgtttgtctt ttggcgataa cctgtttttt taggcagcaa ggaaatcatt
    24541 aaaatgataa agcacaagct ggttaataag aatagtaggg cgcttaggat gcgaaaagac
    24601 tcttcactag cgaaaagtaa ggataatgga gtcataagga gaaccttcca ttttaggtta
    24661 atcagtgatt tttatagcgt ggttaaatta ataataaacc acacctaatc aacgtacctt
    24721 tagtttagtt gtttttacta tttttgtcaa tacataacag tagaaatctt tagttttctt
    24781 atttcagatc gtccaatttg atctttttat gataaaatga gggatatgag taaaaagaaa
    24841 ataggtatga tttcaggtat ctttggattt agtttagcta ttggcctagg aatagttatc
    24901 aaagattatt gccaagacag gcagcgtcga caaatgacaa gggatttacg cacctttttt
    24961 tcacctttag gacaaatcga agttttatat atcaatcctt gtcaggtcaa acaagattat
    25021 atttcaggtg gggttgttat gtcaaacggc aaacagtacc aattcaccta tcacagtcga
    25081 caaattagtt ttgaggagga caagggatga tcagaccgac ttcttatgag ccattagcgg
    25141 ctcttattga aaaagaagat aagctggtgt tattttttac ggcagactgg tgtccagact
    25201 gtcaatttat ttatcctatt atgccagaaa ttgaagcaga acttacagat atgacttttg
    25261 tttgtgttaa tcgtgatcag tttatagagg tagcacaaaa gtggaatatt tttggtattc
    25321 ctagttttgt cgtgattgaa aaaggtcagg aagtagggcg tctggttaac aaaatgagaa
    25381 agacaaaaac tgagattatg cattttttag ctgcttatca ataagaaaag aggaagaata
    25441 aatgattttt gcatacaata aagaacaagt tggcgatgtc ttgatggtta tcttacaaga
    25501 caccaaagat atcaaacgtc aagtagaacg aaaaggcaaa gtagcccgtg tttttgcaga
    25561 agaaagcggc aaaacccttg cttggaatat ctttgaagcg tcaagcttga ttactattga
    25621 aggcaatgga cagatttttt tgacagacga ggaccttgca agattaaatg cagagcttgc
    25681 taaggaagga ttttcagaaa ggcttgaacc gattgtggga cctgtttttg tggttggtca
    25741 aattgttgag atggtggctc atccagatag cgaccatctt aatatctgcc aagtggctat
    25801 tggtgaagat caaacggttc aaatcgtagc gggcgcacca aatgctgcgc ttggtttaaa
    25861 aacgattgtt gccttaccag gtgctataat gcaaaatggt agtctgattt tcccaggaaa
    25921 attgcgtggt gaagaaagtt atggtatgat gtgctctcct cgtgagttag ccttgccaaa
    25981 tgcaccgcaa aaacgtggca ttattgaact tgatgagtca gctgtggtag gagaagcttt
    26041 tgacccagcc aaacattgga aaggttagaa aaaccagctg aaataagact gtatttaact
    26101 aaatgaccag aaaaaaagga ttaggagccc ttaatccttt tttcttatgt tttcaaaaac
    26161 gtttaaaatg aaacttattt taccacaatt tttacgaata ataagataag gaggtcagta
    26221 tgtataataa agtgatagca atcggtcgtt tggtagctaa accagaattg gtaaaaacag
    26281 ctacggataa gcatgtagca cgtctctctt tagctgttaa tcgaagattt aaaaatgctt
    26341 ctggagagcg agaagctgat tttatttcag ttgttgtttg gggaaagtta gcagaaactc
    26401 tggtttctta tgctagcaaa ggtagtttga tgtctattga tggcgaactt aggacccgca
    26461 agtatgataa agatgggcaa gtgcattatg tgacagaagt tctctgccaa tcatttcaac
    26521 tgcttgaaag tcgtgctcag cgcgctatga gagaaaataa tgttactaat gatctagttg
    26581 atttagtctt agaagaagat actcttccct tttgataggg gataatgctt ctcatcacgg
    26641 ttcagctgat tactgaaata tatgatgagg tgatacccga gcaacaaaag tgtgactaga
    26701 tacttctgat aaaaataaaa aaacacctta cgagtatgaa caaagtttca agtgctagat
    26761 gttggaactt tgttcatcat aggaatagta gggtgttttt tagtgtatta cttctttttg
    26821 ttgctagtgt taaggtttac ttgcttacaa gcggttatca ggccactaga actcttataa
    26881 taaatggagc tctttgagtt tggtgtcaat catttttaag acagtcgcca aatcttgtgg
    26941 gttttgaacg aagtcaaggg aattgccatc aattttcatt tttggagaga ccttatagtc
    27001 ttcgtaccag gttgggtatt caccgtggac ttgatggtaa tattgctcaa gactaggatt
    27061 gccgtcgacc tgctcaaaac ttcggccacg tttttcaatg cgctcaagca ttttgtcaaa
    27121 agacacatca atgtagatga gaagatcagg gcgtttttta ggcatgcctt ctagttcttc
    27181 taacatgttg gcgagaagtt cctgatagat gtcaagttct gtcttagtga cattgccatt
    27241 tttgtagtta agttttaaaa agagttcgtc ttcaaaaata gagcggtcaa gaatgttgtt
    27301 atcggcttga taagcttctt tgatggactt aaaccgttta ttcaaaaaat aaatttgaag
    27361 taaaaaggcg tactttttag ggtcttggta gtagaggtct agcacggggt tattatcaac
    27421 agcttcgtaa aaaacgtcag ttcctaaatg ctctccaagt gcagcagcaa gcgagctctt
    27481 gccagcccca attgttccag ctagtacaat caacatgcgt ctccttctaa tatcattagc
    27541 gtactgtttc gaagatggct tcaacctcag ctagagtctc agcgcgtgaa acagcaccac
    27601 gaactttggc agcacctgct gttccgcgaa gatagtgtgg tgctaagccc cgaaattccc
    27661 gaacagcaat ggtttcacct ttgaggttaa tcaggcgttt aaggtggtct ttggcgatgt
    27721 ctaatttttt ggcaaaggga agatcagcca attcttgacc agtttcaaag aaatgattga
    27781 tttgggtaaa aagataagga ttgttcatgg ctgcgcggcc aatcatcacg gcatctacac
    27841 cgatttcttc aatcataaat ttggcgtctt gcaccgaacg cacgtcccca tttccaataa
    27901 agggaatctt agtgatagcc ttagaaactc gggctaatgt ctcatggtcg caggttcctg
    27961 tatacatttg ttcacgggta cgaccgtgca tggcaagagc agatacacct gccgactcag
    28021 cggcaagggc attctcaacg gcaagtgaac tatccgccca acctgtacgc attttgacag
    28081 tcagtggaat atctaaaaca gacgtgactt ccttgacaat gtggtaaatc ttatcagggt
    28141 cacggagcca cttggcacca gcctcgtttt tgacaacttt attaacaggg cagcccatat
    28201 taatatcaac aatatcggcc ttggtattgg tttgaatgaa atcagctgca cgtttcaacc
    28261 cttctgcatc accaccaaat aattgaatgg acatagggtg ctcattctcg tcaatatgga
    28321 gcatatggag ggtcttttcg ttgttgtaga gcagcccttt ttcggaaatc atttccataa
    28381 ccaccaaacc agcaccaaat tctttggcga tggtacgaaa ggcagagttg gtcacgccag
    28441 ccatgggagc aaggacagtg cggtgaggga tttccacatc accaatccta aaggaagaat
    28501 taagctttgt cattgatgag ggcctccaaa tcactttcat taaattggta cttggtacca
    28561 caaaattggc aaacaatctc agcaccctta tcttcgtcaa tcatggcctg taaatctgct
    28621 tttggcaaag tcattagggc tgcttcaaaa cgttctctag aacagtcaca ctgaaaactc
    28681 agaggttctt cagaaagacg cttgtaaggt tcatctccat agatggcctc caaaagggca
    28741 tccacatgat ttttggaagc tagtaggtga gaaatggcag gcatttcttg caggcgtttt
    28801 tcatagcgag caatctcttc ttcagaagct cctggtagca cctgcaccat aaagccacca
    28861 gcaaccttga ccttatcatt ttcatctaaa agcacattaa gtccgattgc agatggtgtt
    28921 tgctctgatt cggttaagta gtaggcaaaa tcctcaccaa tttctccagt aataagaggc
    28981 gttgttgagg cgtaagggtt acctgtgcca taatcaataa tcgtcacaaa atgaccattc
    29041 cccataaaag gcccaacaag gacttcacct gttgcggtct ttttaatatc gacaccagta
    29101 ttttgaatgt aacctttcac atgtcctttg gtatctgcca cagagataat gtgtccaaaa
    29161 gaagaatcac caatcacttt gacggtgatt ttactatcgc ctttttgatt agccgccaaa
    29221 atctggttgg cgatcaaggt acggccaagc gcaacagtag acgatgacag cgtgttgtgt
    29281 ttttcttgag ctaatgcaac cgtctcagtg ctatcaagga cataagccct aaaagcccct
    29341 gattgtgcta ttgatttaat tattttatcc ataacttaga ttatagcata aagtgtaaaa
    29401 cttgtattga caggattgct tgaaaaatca atacagatag acagtaaaaa atcccagaga
    29461 atgactcggg attaagttaa ggtgtggtct aaagtcgcgc aatgtggtga catggagctt
    29521 atgttaattg cttggttaaa tcagcttgga atttttcctc tttaacttga tacatcaatt
    29581 cttggataga cagaatcgat tcatcaaaag atatttcagc aacagcaatt ccttttgtaa
    29641 gctcatgctg aacaaaagga atcagttgac tgtgagtgat gaccaaatct ggctttaaat
    29701 caggaatttg ataaacatta tcttgcaata gataatagga atgaaaatca atgcttttat
    29761 ccgagaaata ccttggaaaa gaatctgtta ggagatgagc attgataaaa ttactggcta
    29821 cgaaaacaac aactaaagga ggttggatat ttcttagaat ttgctcgaca tagtggcaaa
    29881 aaagatgaaa atgcttatgg ttcaagtaac gcttaccagg aagtttggcc atccactctt
    29941 cgacaattaa ctttaaggac gtatagagtt tttggtttcc tttatagtac ggagaaacga
    30001 ataagttggt ctcaggaata aaatgttgca gattaaacaa gaatgatttt gaaaaaaaca
    30061 taagagcttt tactaaacta gccttttgct cttttaggtt aggtaaaaga gtgatgatag
    30121 gatttaaaag caggcgaaaa gtatcatttt cttcaaaaag ttgacaacat tgtctggtat
    30181 gctcaggtgt ccattgtaag ctcgcaaaag aattattagc ggtgatataa attaaataga
    30241 ggtagtccaa atctcctgct gaaaagttta gttggcagta agtttcgata atatcatggc
    30301 tacttttttt caaagaatcg tagacaaaaa gtttttttaa ttgttgaaaa attctggttt
    30361 ggggaatagt taccgaaaat tgatgccgct tccacgataa agccaataaa atgtcataga
    30421 aagaaaacga ttccgataac caaggagagg ttttaaggtg ggtggaacta tgggataaaa
    30481 agctatgaat agtgtttttg tcttgctgcg tcaagtcata aactttaatg ccaaacttac
    30541 tatatagcag agcgatgagg taacggatgc gatattcctc accgacaatc ttgttcttag
    30601 agagttttaa ttcaaagttt cttaataaag gaatcaatgc ttcgcgcatc cgataagctg
    30661 aggagtttga taaaaaatga cttctcgcaa aatccgtaag gggacgagag tgggaaccat
    30721 tttttattaa aaaagctagt aattgtaaga cattagatga tgcatagagt tggtaaagat
    30781 aagtttcttt aaaaggatgt gtaaattggc aagatatcat ccttttttgg atggtcatag
    30841 acagactacc agggaaaaag gcattcagtt cctcacaata atggtttagt tgtaaaaagg
    30901 ttaagccagt tttttctgct acctcagtta ttggcaaata agatgtctta aaaaacaaga
    30961 caactaactg acattttgat tcgattgatg attccaagta tttttctatc aagtaaaggg
    31021 gtcctctctt cctacactta gaaagccaaa taagtctttg ataagtgtat tctcctattt
    31081 caattctatc taagctaaaa atagaaatca aatctaatgg tttttggtga aaagccgaaa
    31141 ccttttgaaa tagctttaaa gcaatatttt ctcaaaaaat cattt
//
LOCUS       DAUDWO010000026        29490 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.026, whole genome shotgun sequence.
ACCESSION   DAUDWO010000026 DAUDWO010000000
VERSION     DAUDWO010000026.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 29490)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 29490)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..29490
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.026"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..1145
                     /locus_tag="VHC05_001123"
     CDS             <1..1145
                     /locus_tag="VHC05_001123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="class I SAM-dependent rRNA methyltransferase"
                     /protein_id="HEQ5402440.1"
                     /translation="SFVEKKLTAGVQLLDEKDFSNIKEKNQLVQLVTKSNRPIGTAYI
                     SKQNKGIGWYLGPEKIDLSISYFVSLFSVAKAKRQDFAQSDETNAYRLFNQEGDGFGG
                     VTIDLYKDFAVFSWYNAFVYDKKEMIMEAFQQVFPEVKGAYEKCRFKGPDTETAHLYG
                     ELAQETFSILENGIAYQVFLNEGLMTGIFLDQHDVRRALVDGLAMGKSLLNLFSYTAA
                     FSVAAAMGGAIETTSVDLAKRSRELSLAHFEHNQLNLASHHFVVMDVFEYFKYAKRKK
                     LIFDVIVIDPPSFARNKKQTFSVSRDYHKLITEALDILSPKGTIIASTNAANMTVSQF
                     KKQIIKGFGSRRPESMTLQQLPSDFTINKADERSNYLKVFTIKVRE"
     gene            1142..1828
                     /locus_tag="VHC05_001124"
     CDS             1142..1828
                     /locus_tag="VHC05_001124"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HEQ5402441.1"
                     /translation="MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAV
                     APAIFEKFAGKEIIFTLRTVQEGGNITLSSQEYVDIIKEINAIYNPDYIDFEYFTHKS
                     VFQEMLDFPNLILSYHNFEETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNY
                     TRGFKTLNPEQEFATISMGKLGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRI
                     IEVLEMDISN"
     gene            1922..3088
                     /gene="aroC"
                     /locus_tag="VHC05_001125"
     CDS             1922..3088
                     /gene="aroC"
                     /locus_tag="VHC05_001125"
                     /EC_number="4.2.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate synthase"
                     /protein_id="HEQ5402442.1"
                     /translation="MRYLTAGESHGPSLTAIIEGIPAGLTLHPADIDHELQRRQGGYG
                     RGARMSIETDRVQISSGVRHGKTTGAPITLTVINKDHQKWLDVMAVGDIEETLKLKRR
                     VKHPRPGHADLVGGIKYHFNDLRDALERSSARETTMRVAVGAVAKRILAELGIDMLHH
                     ILIFGGITITIPSKLSFRELQERALHSELSIVNPKQEEEIKTYIDKIKKEGDTIGGII
                     ETIVQGVPAGLGSYVQWDKKLDAKLAQAVLSINAFKGVEFGVGFDMGFQKGSQVMDEI
                     TWTPTQGYGRQTNHLGGFEGGMTTGQPLVVKGVMKPIPTLYKPLMSVDIDSHEPYKAT
                     VERSDPTALPAAGVIMENVVATVLAKEILETFSSTTMSELQKAFSDYRAYVKQF"
     gene            3149..3490
                     /locus_tag="VHC05_001126"
     CDS             3149..3490
                     /locus_tag="VHC05_001126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbF/YmcA family competence regulator"
                     /protein_id="HEQ5402443.1"
                     /translation="MSQEIYDYANQLERAVRALPEYQKVLEVKEAIQADASASELFDE
                     FVAMQEKIQEMMQSGQMPTAEEQTSIQELSQKIEANDQLKAYFEAQQALSVYMSDIER
                     IVFAPLKDLVK"
     gene            3712..5064
                     /gene="gorA"
                     /locus_tag="VHC05_001127"
     CDS             3712..5064
                     /gene="gorA"
                     /locus_tag="VHC05_001127"
                     /EC_number="1.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-disulfide reductase"
                     /protein_id="HEQ5402444.1"
                     /translation="MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVN
                     LGCVPKKVMWYGAQVADILGTYAKDYGFDFKDKAFDFKQLKANRQAYIDRIHASYERG
                     FEQNGVDRIYDYAVFKDAHTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGF
                     FALDEVPKRTAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSFDKAIVDVLVEEM
                     AVGGPCLHPHSEVAKVVKNTDESLTLYLKDGQEVEVDQLIWAIGRKPNLEGFGLDKTG
                     VTLNDKGYIETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKL
                     DYQNVATVIFSHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMK
                     LVTVGDTEKIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
                     "
     gene            complement(5152..6420)
                     /locus_tag="VHC05_001128"
     CDS             complement(5152..6420)
                     /locus_tag="VHC05_001128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990257.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HEQ5402445.1"
                     /translation="MTTYDSISWIHSFKANGRKTDLARMAWLLEALGRPQDKFPAIHV
                     VGTNGKGSVTAYLQHILSTSGYQVGTFTSPFIISFHDRICLNGQPISDLELAQCVSVI
                     RPILTKMSLETNWDRPTEFELVTLIMFCYFANLKPVDIAIIEAGIGGKTDATNVFHAL
                     AVVCPSISFDHQERLGYSLAEIAHQKAEVIKAKEPVIIGQLEQEASQVFQQVTQKAGS
                     RLYQLGKDFLLNPSEKTISFQHDNLNLTKLRLKLLGQHQKANACLAIMTAQLLRKSFP
                     KISPKTIQKGIETTTWPGRSEFIQPNLLLDGAHNPDSIAKLKSLMQEEFPKRPIHILF
                     AGLKRKPLADLLAQLDTFEVSVTTFDFPEANLLEDYPDKYPQVKDYRDWLQGSVTSDE
                     LFVVTGSLYFISKVRQYCLSNANIFKNIFP"
     gene            complement(6450..6890)
                     /locus_tag="VHC05_001129"
     CDS             complement(6450..6890)
                     /locus_tag="VHC05_001129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402446.1"
                     /translation="MSSHYSRQQKPRKSGGVPTEHIKTGFTAFQKSIALIGSILSIIV
                     ATITITRALQPVPDKTSNDTPKESSNTIVKIIEKESSQGNQNHTGTPETTDDNKTTLP
                     SSSTTPSHNETTPTAPETPSTTEGTQLPNATGAEDANTGLPTNP"
     gene            7125..8267
                     /locus_tag="VHC05_001130"
     CDS             7125..8267
                     /locus_tag="VHC05_001130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012766813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEQ5402447.1"
                     /translation="MIYFDNAATTIPYGEALKTYQEVATKIYGNPSSLHQLGTNASRI
                     LEASRKQIAGLLGVKSEEIFFTSGGTESANWAIKGIAFEKTAFGKHIIISAIEHPAVS
                     ESVKWLLTQGFEVSYAPVTTQGVVDVNALAELIRPDTILISIMAVNNEMGAIQPIRAI
                     SNLLANQPTITFHVDAVQAIGKIPLCDYMTNRVDLASFSGHKFHSVRGVGFLYKKAGK
                     RLNPLLSGGGQEQELRSTTENVAGIASMAKALRIVTEKQVSVLPKLTAMRDVIYKALS
                     AYPDVTVFSAQEGFAPNILTFGIRGVRGEVIVHAFEKYEIYISTTSACSSKAGKPAGS
                     LVAMGVPVKTAQTAVRISLDDDNDMGQVEQFLTIFKQIYDKTQKVR"
     gene            8279..9493
                     /gene="thiI"
                     /locus_tag="VHC05_001131"
     CDS             8279..9493
                     /gene="thiI"
                     /locus_tag="VHC05_001131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 4-thiouridine(8) synthase ThiI"
                     /protein_id="HEQ5402448.1"
                     /translation="MDYSEIMVRHGELSTKGKNRMRFINKLKNNIQDVLAPFPAITVR
                     SDRDRTHVSLNGTDYQPIVEALKLVFGVQALSPVYKLEKSVPLLVTAVQDIMTSLYRD
                     GLTFKIATKRSDHAFELDSRELNSLLGGAVFEVLPNIQAQMKHPDVTLKVEIRDEAAY
                     ISYEEIKGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGLDIEVVHFASPPYTSPG
                     ALAKAQDLTRRLTRFGGNIQFIEVPFTEIQEEIKNKAPEAYLMTLTRRFMMRITDAIR
                     EQRKGLVIVNGESLGQVASQTLESMQAINAVTSTPIIRPVVTMDKLEIIEMAQAIDTF
                     DISIQPFEDCCTIFAPDRPKTNPKLSNAEKYEERFDIDGLVQRAVSGIVVTEITPEIV
                     NDEVENLIDALL"
     gene            9531..10823
                     /locus_tag="VHC05_001132"
     CDS             9531..10823
                     /locus_tag="VHC05_001132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CapA family protein"
                     /protein_id="HEQ5402449.1"
                     /translation="MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTM
                     ATVVALIVALLLFGLIYDLLGVQKNELAAQKSAQPKVKAARVVANGDILIHDILYMSA
                     RKADDTYDFTPYFEYVKDWISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKN
                     TGYDVVDLAHNHILDSQLDGALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKI
                     AILGYSYGYNGMEATLSQEDYEKHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYA
                     LEPTAEQKELYHKMIDWGADVVLGGHPHVIEPSETVIKGRQKKFIIYSMGNFISNQRL
                     ETVDDIWTERGLLMDLTFEKKDNKTKIKTVEAHPTMVLAKGKGIVGKEGFELYNYRTM
                     VLEDFIKGGKYHDKIDEETKAKVALAYQEINDLVNLKW"
     gene            complement(10842..11726)
                     /locus_tag="VHC05_001133"
                     /pseudo
     CDS             complement(10842..11726)
                     /locus_tag="VHC05_001133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767065.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     misc_feature    11961..12035
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00559"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L21 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00559"
     gene            12070..12384
                     /gene="rplU"
                     /locus_tag="VHC05_001134"
     CDS             12070..12384
                     /gene="rplU"
                     /locus_tag="VHC05_001134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L21"
                     /protein_id="HEQ5402450.1"
                     /translation="MSTYAIIKTGGKQVKVEVGQAIYVEKIDAEAGAEVTFNEVVLVG
                     GDKTVVGTPVVEGATVVGTVEKQGKQKKVVTFKYKPKKGSHRKQGHRQPYTKVVINAI
                     NA"
     gene            12396..12722
                     /locus_tag="VHC05_001135"
     CDS             12396..12722
                     /locus_tag="VHC05_001135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal-processing cysteine protease Prp"
                     /protein_id="HEQ5402451.1"
                     /translation="MIKAIFTRQKNGQLSSVTLTGHAGSGKHGFDIVCASVSTLAINF
                     VNSLEVLADCQALVDLNDVEGGYMAITIPPHDNKEEVQLLFESFLLGMTSLAKDSSKF
                     VNTQVI"
     gene            12750..13043
                     /gene="rpmA"
                     /locus_tag="VHC05_001136"
     CDS             12750..13043
                     /gene="rpmA"
                     /locus_tag="VHC05_001136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L27"
                     /protein_id="HEQ5402452.1"
                     /translation="MLKMNLANLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVSG
                     GSILYRQRGTHIYPGVNVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPVAK"
     gene            13401..14315
                     /locus_tag="VHC05_001137"
     CDS             13401..14315
                     /locus_tag="VHC05_001137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEQ5402453.1"
                     /translation="MNIQQLRYVVAIANNGTFREAASKLFVSQPSLSVSIKDLEAELG
                     FQIFNRTTSGTVLTSQGLVFYEKALEVVKSFDSFEKTFSQADLDQNEFSIASQHYDFL
                     PPLITAFSQQYDGHRVFRIFESTTIQILDEVAQGNSEIGIIYLNVDNQKGLFQRMDKL
                     GLEYVSLIPFTTHIYLSKTHPLANREALYLSDIQGLPAVRFTQEGDEYLYYSENFVDT
                     SECPRIYNVSDRATLNGILERTNAFATGSGFLDHRSVNGIKVIPLADHIDNQMIYVKR
                     KDKNLSVAGATFVTILKDYFDKRRKALT"
     gene            14312..14770
                     /locus_tag="VHC05_001138"
     CDS             14312..14770
                     /locus_tag="VHC05_001138"
                     /EC_number="3.4.23.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HEQ5402454.1"
                     /translation="MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLT
                     YLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGN
                     FIDRLRLAYVIDMVHLDFVDFAIFNVADSYLTVGVILLVICLWKEEDYGN"
     gene            14760..15650
                     /locus_tag="VHC05_001139"
     CDS             14760..15650
                     /locus_tag="VHC05_001139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEQ5402455.1"
                     /translation="MEINVITSGQRLDKALADLSPLSRGQANDQIKQGLVLVNGQQKK
                     AKYTVQAGDVICFELPKEEVLEYQAQNIPLDIIYEDDTLAIINKPQGMVVHPSAGHPS
                     GTMVNALMYHIKDLSSINGVVRPGIVHRIDKDTSGLLMVAKTDAAHQALAEELKAKKS
                     LRKYLAIVHGNLPNDRGMIEAPIGRSEKDRKKQAVTAKGKEAVTRFTVLERFGDYSLV
                     ELQLETGRTHQIRVHMAYIGHPVAGDPLYGPRKTLSGHGQFLHAKTLGLTHPMTGKEM
                     IFTVEAPEIFQKVLKLLRKK"
     gene            16045..16566
                     /gene="pyrR"
                     /locus_tag="VHC05_001140"
     CDS             16045..16566
                     /gene="pyrR"
                     /locus_tag="VHC05_001140"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009881107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="HEQ5402456.1"
                     /translation="MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVF
                     LARRIQERLHQLEGLDLPIGELDIKPFRDDMRVEEDTTLMSVDITGKDVILIDDVLYT
                     GRTIRAAIDNLVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSSVEEIVVEVVE
                     VDGRDRVSIIDPT"
     gene            16582..17841
                     /locus_tag="VHC05_001141"
     CDS             16582..17841
                     /locus_tag="VHC05_001141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil permease"
                     /protein_id="HEQ5402457.1"
                     /translation="MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPS
                     VALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGAMTGGLVY
                     LIVALIVKVIGNDWIDKILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIG
                     LVTLLSVIFFNIYGKGIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFS
                     IPSVEIPFLTYGVKFYPSAILTMAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKT
                     LTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSA
                     LIQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLML
                     QVNGLQISGVAFSTLLGIILYQVLPEK"
     gene            17902..18837
                     /locus_tag="VHC05_001142"
     CDS             17902..18837
                     /locus_tag="VHC05_001142"
                     /EC_number="2.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate carbamoyltransferase catalytic
                     subunit"
                     /protein_id="HEQ5402458.1"
                     /translation="MSVVNNRVALTNLVSMEALTTEEVLGLINRGSEYKAGKVVISDH
                     QKDLVANLFFENSTRTHKSFEVAEKKLGLTVLDFNADASAVNKGESLYDTVLTMSALG
                     TDICVIRHPEDDYYKELVESPTITASIVNGGDGSGQHPSQCLLDLLTIYEEFGRFEGL
                     KIAIAGDLTHSRVAKSNMQILKRLGAELYFYGPEEWYSEAFNAYGTYIAIDQIIKELD
                     VLMLLRVQHERHDGHQSFSKESYHQAFGLTQERYQQLKDSAIIMHPAPVNRDVEIADS
                     LVEAPKARIVSQMANGVFVRMAIIEAILNGRNKNS"
     gene            18881..19963
                     /gene="carA"
                     /locus_tag="VHC05_001143"
     CDS             18881..19963
                     /gene="carA"
                     /locus_tag="VHC05_001143"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HEQ5402459.1"
                     /translation="MTKRLLILEDGTIFEGEPFGADIDVTGEIVFNTGMTGYQESITD
                     QSYNGQILTFTYPLIGNYGINRDDYESISPTCKGVVVSEVSRLASNWRKQMTLDAFLK
                     IKGIPGISGIDTRALTKIIRQHGTMKATMADDGDSIQHLKDQLRATVLPTNTIEQVST
                     KTAYPAPGIGKNIVLVDFGLKHSILREFSKRQCNITVVPFNITAEEVLQLNPDGLMLS
                     NGPGNPEDLPEALDMIRGVQGKIPIFGICMGHQLFSLANGAKTCKMTFGHRGFNHAVR
                     EIATGRIDFTSQNHGYAVERSSLPDTLMVTHEDINDKTVEGVKHRDFPAFSVQFHPDA
                     APGPHDASYLFDEFLEMIDSWRCTSK"
     gene            20209..23385
                     /gene="carB"
                     /locus_tag="VHC05_001144"
     CDS             20209..23385
                     /gene="carB"
                     /locus_tag="VHC05_001144"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004218948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HEQ5402460.1"
                     /translation="MPKRKDIQKIMVIGSGPIIIGQAAEFDYAGTQACLALKEEGYKV
                     ILVNSNPATIMTDKEIADKVYIEPLTLEFVNRIIRKERPDAILPTLGGQTGLNMAMAL
                     SKAGILDDLEIELLGTKLSAIDQAEDRDLFKQLMQELDQPIPESTIVKTVDEAVTFAR
                     DIGYPVIVRPAFTLGGTGGGICSSEEELCEITENGLKLSPVTQCLIERSIAGFKEIEY
                     EVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPTQTLSDIENQMLRDASLKIIRALK
                     IEGGCNVQLALDPYSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEM
                     INPITGTTYAMFEPALDYVVAKIPRFPFDKFEHGERQLGTQMKATGEVMAIGRNLEES
                     LLKACRSLEIGVCHNEMTSLSNISDEELVTKVIKAQDDRLFYLSEAIRRGYSIEELES
                     LTKIDLFFLDKLLHIVEIEQELQMHVDHLESLKKAKRYGFSDQKIAEIWQKDESDIRA
                     MRHSHSLYPVYKMVDTCAAEFDAKTPYFYSTYELENESVQSNKESILVLGSGPIRIGQ
                     GVEFDYATVHSVKAIQKAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDL
                     EQPKGVIVQFGGQTAINLAQALSEAGVTILGTQVEDLDRAEDRDLFEKALKELGIPQP
                     QGQTATNEEEALEAAKKIGFPVLVRPSYVLGGRAMEIVENKEDLIEYIRTAVKASPEH
                     PILVDSYIFGKECEVDAISDGKSILIPGIMEHIERAGVHSGDSMAVYPPQQLSKQIQE
                     TIAEYTKRLAIGLNCIGMMNVQFVIKNEQVYVIEVNPRASRTVPFLSKVTGIPMAQIA
                     TKLILGQTLKDLGYEDGLYPQSQLVHIKAPVFSFTKLAQVDSLLGPEMKSTGEVMGSD
                     TSLEKALYKAFEANNSHLSEFGQIVFTIADDSKAEALSLARRFKAIGYQIMATQGTAA
                     YFAEQGLSACLVGKIGDAANDIPTLVRHGHVQAIVNTVGIKRTADKDGQMIRSSAIEQ
                     GVPLFTALDTAKAMLTVLESRCFNIEAI"
     gene            23590..24861
                     /locus_tag="VHC05_001145"
     CDS             23590..24861
                     /locus_tag="VHC05_001145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HEQ5402461.1"
                     /translation="MSKRGKIKITTKTKLITASVITLVLIITGVVLWKQQQNTLTADI
                     AKEPYSTVSVTEGSIASSTLLSGTVKALSEEYIYFDANKGNDATVTVKVGDQVTQGQQ
                     LVQYNTTTAQSAYDTAVRSLNKIGRQINHLKTYGVPAVSTETNKDEATGEETTTTVQP
                     SAQQNANYKQQLQDLNDAYADAQAEVNKAQIALNDTVVISSVSGTVVEVNNDIDPSSK
                     NSQTLVHVATEGQLQVKGTLTEYDLANVKVGQSVKIKSKVYSNQEWTGKISYVSNYPT
                     ESNAGSTTPAGSTGAGSSTGAAYDYKIDIISPLNQLKQGFTVSVEVVNEAKQALVPLT
                     AVIKKDKKHYVWTYDDATGKAKKVEVTLGNADAQQQEIHKGVTVGDIVIANPDKNIKP
                     DKKLEGVISIGTNTKPEKDSQSKNKKSGVDK"
     gene            24861..25571
                     /locus_tag="VHC05_001146"
     CDS             24861..25571
                     /locus_tag="VHC05_001146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402462.1"
                     /translation="MSHEKKQLMQLSNIVKSYQNGDQVLKVLKGINLTVYEGEFLAIM
                     GPSGSGKSTLMNIIGLLDRPTSGDYTLHNTKIEILNDRELAKVRNDEIGFVFQQFFLL
                     AKLTALQNVELPLIYAGVNVSKRREQAKQFLEKVGLGRRIKHLPSELSGGQKQRVAIA
                     RALVNDPSIILADEPTGALDTKTGQQIMELLTELNKEGKTIIMVTHEPEIADFATRKI
                     IIRDGDITTDTTASVVID"
     gene            25583..26803
                     /locus_tag="VHC05_001147"
     CDS             25583..26803
                     /locus_tag="VHC05_001147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402463.1"
                     /translation="MENWKFALSSIWGHKMRSILTMLGIIIGVAAVVIIMGLGNAMKN
                     SVTSTFSSKQKDIQLYFQEKGEEEDLYAGLHTHENNHEVKPEWLEQIVKDIDGIDSYY
                     FTNSATSTISYEKKKVDNASIIGVSKDYFNIKNYDIVAGRTLTDNDYSNFSRIILLDT
                     VLADDLFGEGNYKSALNKVVSLSDKDYLVIGVYKTDQTPVSFDGLSGGAVMANTQVAS
                     EFGTKEIGSIYIHVNDIQNSMNLGNQAADMLTNISHIKDGQYAVPDNSKIVEEINSQF
                     SIMTTVIGSIAAISLLVGGIGVMNIMLVSVTERTREIGLRKALGATRLKILSQFLIES
                     VVLTVLGGLIGLLLAQLSVGALGNAMTLKGACISLDVALIAVLFSASIGVFFGMLPAN
                     KASKLDPIEALRYE"
     gene            27057..28790
                     /locus_tag="VHC05_001148"
     CDS             27057..28790
                     /locus_tag="VHC05_001148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphoryl diester phosphodiesterase
                     membrane domain-containing protein"
                     /protein_id="HEQ5402464.1"
                     /translation="MTFLSDLISLMTKIRLSWVIKAGIFQLLFVTIANIVLSEFFYFI
                     LDVTGQYHLDKDNVVTFLKNPIALALLGAYLFLLAAFIHLEFFALYRIIADQEISFYL
                     FRKQFSYYLRGLWKTFSGYQLLLFLLYILLTIPVLHIGLSSVITQKLYLPEFIVGELS
                     KITSTKYLLYGSLILVFYLNLRLVYFLPLIAINHRTVAQAWRESWQKTKKKHVLLWMK
                     LFAINGLTLVVLSLAISMILIFVDMFNPKGNNIIVQLGALTFTWELIFFTTIFFKLCS
                     AMILKEAIEPQKQYDEPRRSNKAYVVIFIVVTVGFAYQSLERLTFFDTSHSKTVIAHR
                     GLVSAGVENSLEALEGAKKAGSDYVELDLILTKDNHFVVSHDNRLKRLAGVNKTIRNL
                     TLKEVEHLTSHQGHFSGRFVSFDTFYQKAKKLNMPLLIELKPIGTEPGNYVDLFLETY
                     HRLGISKDNKVMSLDLEVIEAIKKKNPSITTGYIIPIQFGFFGDEFVDFYVIEDFSYR
                     SYLSSQAFWNNKEIYVWTINDPKRIEHYLLKPIQGIITDQPALTNQLIKDLKQDNSYF
                     SRLVRIISSLY"
     gene            28917..29189
                     /gene="rpsP"
                     /locus_tag="VHC05_001149"
     CDS             28917..29189
                     /gene="rpsP"
                     /locus_tag="VHC05_001149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S16"
                     /protein_id="HEQ5402465.1"
                     /translation="MAVKIRLTRMGSKKKPFYRINVADSRAPRDGRFIETVGTYNPLV
                     AENQITIKEDRVLEWLSKGAQPSDTVRNILSKAGVMAKFHDQKFSK"
     gene            29199..29438
                     /locus_tag="VHC05_001150"
     CDS             29199..29438
                     /locus_tag="VHC05_001150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KH domain-containing protein"
                     /protein_id="HEQ5402466.1"
                     /translation="MDTIENLIIAIVKPLISQPDNLTIKIEDTPDFLEYHLDLDAQDI
                     GRVIGKKGRTITAIRSIVYSVPTLGKKVRLVIDEK"
BASE COUNT         9191 a         4951 c         6245 g         9103 t
ORIGIN      
        1 attcttttgt cgaaaagaag ctgacagcag gggtacaatt attagatgaa aaagattttt
       61 ctaatataaa ggaaaaaaat cagttggttc aactggtgac caagtccaat cgtcccattg
      121 gaacagcata tatctctaag caaaataaag gaattggttg gtatctagga ccagaaaaaa
      181 tcgacttgtc tatctcttat tttgttagtc tattttcagt tgctaaagcc aaaagacaag
      241 attttgctca atcggacgag accaatgctt atcgcctttt taatcaagaa ggagacggtt
      301 ttggtggagt aacaattgat ctttataaag attttgcagt cttttcatgg tacaatgcct
      361 ttgtctatga caaaaaagaa atgattatgg aggcttttca acaggttttt cctgaagtca
      421 aaggagctta tgaaaagtgt cgctttaaag gtccagatac tgaaactgct catctgtatg
      481 gtgagctggc acaagaaacc ttttcgattt tagaaaatgg catagcctat caagtcttct
      541 tgaatgaggg cttaatgaca ggtatttttc tagaccagca tgatgttaga agagcactag
      601 tagatggttt agctatgggc aagtcccttc ttaacctatt ttcctataca gctgcctttt
      661 ctgtagcagc tgctatgggt ggtgctatcg agaccacttc tgtggacttg gctaaacgat
      721 cgagagaatt atcactagct cattttgagc ataaccagtt aaacttagcc tcacatcatt
      781 ttgtggtgat ggatgttttt gaatacttca aatatgccaa acggaaaaaa ttaatttttg
      841 atgtgattgt gattgaccca ccaagctttg ctagaaataa aaaacaaact ttctctgtga
      901 gcagggacta ccacaaatta atcacagagg ccttggacat attgagtcct aagggaacta
      961 ttatagcttc aacaaatgct gctaatatga ctgttagcca gttcaaaaag caaattatca
     1021 aaggatttgg aagtcgtcgt cctgagtcta tgactctcca gcagcttccg agtgacttta
     1081 ctatcaataa agcagatgaa agaagtaact atttaaaggt atttactata aaggtacgag
     1141 aatgagaatt gtagcaccag tcatgccaag acattttgac gaggctcaag ccattgatat
     1201 ttctaaatat gaagatgtta atttaattga atggcgagca gactttcttc ccaaggatga
     1261 gattgtcgca gtagcaccag ctatttttga aaaatttgcc ggaaaagaaa ttatctttac
     1321 ccttcggacc gttcaagaag gggggaatat taccctttca agtcaggagt atgttgatat
     1381 tatcaaagaa atcaatgcta tttataatcc agactatatt gactttgagt attttacgca
     1441 caagtcagta tttcaagaaa tgcttgattt tccaaatctt attttgtctt atcacaactt
     1501 tgaagagact cctgaaaatt taatggaagc tttttcagaa atgaccaagt tggcaccgcg
     1561 tgtggttaaa attgctgtga tgccccagag tgaacaagat gttctagatt tgatgaacta
     1621 taccagaggc tttaagacgc tcaatcctga gcaagaattt gcaactatat ctatggggaa
     1681 attaggaaga ttgtctcgtt ttgcgggaga tgtcattggc tcttcctgga catacgtttc
     1741 attagatcat gttagcggtc caggtcaagt gactctcaat gatatgaaac gtattattga
     1801 ggtcttagaa atggatatct ctaactagtg aatggtctaa aaatattatt tctacaatag
     1861 ttaagaaatg atgtttttag attaatgttt ttaaaataag tggaaccaaa aaggagaaaa
     1921 attgcgttat ttaacagcag gagaatctca tgggccatcc ttaacagcta ttattgaagg
     1981 tataccagca ggattaactc ttcatccagc ggatattgat cacgaattac agcgacgtca
     2041 aggaggttat ggccgtggtg ccagaatgtc tattgagact gatcgggttc aaatatcctc
     2101 aggagttcgt catggcaaaa caacaggggc ccccattacc ttaacggtaa ttaataagga
     2161 ccaccaaaaa tggctagatg tcatggctgt aggagacatt gaagagactc tcaagttaaa
     2221 gcgtcgtgtt aagcatccta gaccaggaca tgcggatttg gtaggaggta ttaaatatca
     2281 ttttaacgat ttaagagatg ctttagagcg ttcctcggct agagaaacaa cgatgagagt
     2341 ggctgtaggc gctgttgcta aacgtatctt agctgaactt ggaattgata tgttacatca
     2401 tatcttaata tttggtggta taacgatcac aataccttct aagctctctt ttagagagtt
     2461 gcaagaaagg gctctccatt cagaattatc tattgttaat ccaaagcaag aagaagaaat
     2521 taaaacgtat attgataaga taaaaaaaga aggggatact attggtggta ttatcgaaac
     2581 gatagttcaa ggggtgccag caggtcttgg atcttatgtc caatgggata aaaaattaga
     2641 tgccaagctg gctcaagcag ttctttccat taatgctttt aaaggggtgg aatttggagt
     2701 tgggtttgat atgggattcc aaaagggctc tcaggtaatg gatgaaatca cctggacacc
     2761 tacccaaggc tatggtcgtc aaacaaacca cttaggtggc tttgaaggtg gcatgaccac
     2821 aggacaacct cttgttgtta aaggggttat gaagcccatt cctactttgt ataaaccact
     2881 catgtcggta gatattgata gtcatgaacc ttataaagca acggtggaac gctctgatcc
     2941 gacggcctta ccagctgcag gggttatcat ggaaaatgtg gtggcgacgg tgcttgccaa
     3001 agagatttta gagacttttt cttctactac catgtctgaa ttgcaaaaag ctttttcgga
     3061 ctatcgtgcc tacgtcaagc aattttagat agcgagatac tggcttttat ggtatcatac
     3121 aggtattaat gaacaaaagg agactgtcat gtcacaagaa atttatgact atgctaatca
     3181 acttgaaaga gcagttcgtg ctctgccaga ataccaaaaa gtgttagaag taaaagaggc
     3241 cattcaagca gacgctagtg ctagcgaact gtttgatgag tttgtcgcta tgcaagaaaa
     3301 aatccaagag atgatgcaat caggccaaat gccaacggct gaagaacaaa caagcattca
     3361 agaacttagc caaaagattg aagctaatga ccagctaaaa gcttattttg aagcgcagca
     3421 ggccttatct gtttacatga gtgatattga gcgtattgta tttgctccgt tgaaagattt
     3481 agtcaagtaa gccaattaag ataggaaaaa aaacagattg ctggcagctc gtcaggatct
     3541 gttttttagt gtttattttc tttgtatcag aaagttgagc ctctttctta tttgtgatat
     3601 agtcaaataa attgaccaaa atagcaggcc agtagtggct ttaatgaagg caagttgtct
     3661 gctaactggc tatgctaaaa catcagtatt agaaagtaaa aggttataaa aatggttatt
     3721 ccttatgatt atattgttat tggtggaggg agtgcaggta ttgcttctgc gaacagggca
     3781 gccatgcatg gggccaaagt attgttagct gaaggtaaag agattggggg aacctgtgtt
     3841 aacctaggct gcgttcctaa aaaagtcatg tggtatggcg ctcaagtagc agatatttta
     3901 gggacttacg ctaaggatta tggatttgac tttaaagaca aagcatttga ttttaaacaa
     3961 ttgaaagcaa atcgtcaagc ttatattgat cggattcatg cttcttatga gcgaggcttt
     4021 gagcagaatg gtgttgaccg tatttatgat tatgctgttt tcaaagatgc tcatacggta
     4081 gaaattgcag ggcagcttta taccgcaccg catattttga ttgccacagg aggacatcct
     4141 gtttttccag atattgaggg ggcacaatac ggtatcagct cggacggctt ttttgcctta
     4201 gatgaggtac caaaacgtac ggctgtggtt ggggcaggct atattgctgt ggaacttgct
     4261 ggtgttttgc atgctttggg atcgaagacg gatttgttta tccgtcacga tcgaccttta
     4321 agaagttttg acaaagccat tgtggatgtt ttagttgagg aaatggcagt tggtggtcct
     4381 tgcttacacc ctcattcaga agtggcaaag gttgtcaaaa atactgatga gtccttgacc
     4441 ctttacctca aagatggcca agaagttgag gttgaccagc tcatttgggc tatcggtcgc
     4501 aagcctaatc tagaaggttt tggtcttgac aaaactggag tgacgttaaa tgataaaggt
     4561 tatattgaga cagatgccta tgaaaacacg tctgtcaaag ggatttatgc agtaggtgat
     4621 gtcaatggta aactggcttt aactccagtt gctgtggcag ctggacgtcg cctatcagag
     4681 cgtcttttca atggcaaaac agacgagaaa ttggactacc aaaacgttgc tactgtgatt
     4741 tttagtcacc ctgttattgg ctctgttggc ttgtcagaag aagcagcagt caaacagtat
     4801 gggcaagaag cagttaaaac atatcaatca cgttttacgt ctatgtttac tgctatcact
     4861 aaccatcgcc aaccttgtct gatgaagttg gtaacagtcg gagataccga aaaaatagtt
     4921 ggtcttcacg gaatcggata cggggttgac gaaatgattc agggctttgc agtagccatc
     4981 aaaatgggag caaccaaggc ggattttgat aacaccgttg ctattcaccc aactggctca
     5041 gaagaatttg tcaccatgcg ctaaaaaatg tagcctaagg caataaaaaa tgatgttaac
     5101 agtttttgag gaaagtcttc taaactgcta gcatcgtttt ttgttaggtg attaggggaa
     5161 tatgttttta aagatatttg cgttgctcag acaatattgc cttaccttgg agataaaata
     5221 aagtgaccct gtaacaacaa agagttcatc agatgttacg gaaccttgta accagtctct
     5281 gtaatctttt acctgtgggt atttatcagg ataatcctct aaaagatttg cttcagggaa
     5341 atcaaaagtc gtgacagata cttcaaaagt atctagttga gccagcaagt cggctaaagg
     5401 cttacgtttg agacctgcaa agaggatatg aataggacgt ttgggaaatt cttcttgcat
     5461 tagagacttt aatttagcaa tggaatctgg attgtgagcg ccgtctaata gaagattagg
     5521 ttgaataaat tcggaccggc caggccaagt tgttgtctca attccttttt gaatcgtttt
     5581 tggagatatt ttaggaaagg attttctaag taattgagct gtcataatgg ctaaacaggc
     5641 attcgctttt tgatgttgac ctaatagttt gagacggagt ttggttaaat tcaagttatc
     5701 gtgttgaaag gaaatcgtct tttctgaagg attgagcaaa aaatcttttc ctaattgata
     5761 taagcgtgaa ccggcttttt gggtaacttg ttgaaagact tgactagcct cctgttcaag
     5821 ttgaccgata ataacgggtt ctttagcttt gataacttct gctttttggt gagcaatttc
     5881 tgctaggcta taacctaaac gttcttggtg atcaaaacta atggaagggc atacgacggc
     5941 cagagcatga aagacattgg ttgcgtcggt tttcccacca atccctgcct caataatggc
     6001 aatatcaaca ggtttaagat tggcaaagta gcaaaacatt atgagagtca ctaactcaaa
     6061 ctcggtaggt ctatcccaat ttgtttcaag ggacatttta gtgagaatgg gtctaatcac
     6121 gctcacacat tgcgccaatt ctaggtctga aatgggctgg ccattaaggc agatccgatc
     6181 gtgaaaagag atgataaaag gagatgtaaa ggttccgacc tgataaccag aagttgacag
     6241 gatatgctgt aagtaggctg tcacagagcc cttgccgtta gttccaacaa cgtgaatagc
     6301 agggaatttg tcttgtggcc ggcctagtgc ctcaagtaac caagccattc tggccaaatc
     6361 ggtcttgcga ccattagcct taaagctatg aatccaggaa atgctatcat aggtagtcat
     6421 tactatttct tgtccttcta acaatgcttc taagggttcg taggaagacc agtattagca
     6481 tcttcagctc cagttgcatt agggagttgc gtcccttcag tggttgatgg tgtctcaggg
     6541 gctgtaggag ttgtctcgtt gtgagaaggt gtggtagaag atgacggaag agttgtctta
     6601 ttatcatctg tggtttctgg agtacctgta tggttttgat taccctgaga agactctttt
     6661 tcaataatct tgacaatggt attactcgat tctttgggtg tatcattaga ggtcttatct
     6721 ggtacaggct gcagtgctct tgtaatggta atggttgcca caatgatact caaaatacta
     6781 ccaataagtg caatggattt ttggaaagct gtaaaacctg ttttaatatg ctcggtaggg
     6841 acacctcctg atttacgagg tttttgttga cgggaataat gtgatgacat atttttctcc
     6901 tttaaaatca tcgtaatgcc aagattaagg aggaggaaat agaagttcta gctcctcttt
     6961 aacacttcat ctatcagtat aatctagaaa aaaagtgaag tcaacggttt accttatgtc
     7021 taggacaagg aagtcctttg ggcttattgt aatacgaata ttcttgattt cattttagct
     7081 attttgtgat agaataaagt attgagtaaa aatgaaggtg acacatgatt tattttgata
     7141 atgcagccac aaccatacct tatggagagg ctcttaaaac ttaccaagaa gtagcaacaa
     7201 aaatatatgg caatccctca agtctgcacc aactagggac aaatgcgtct cgcattttag
     7261 aagcttcccg taaacagatt gctggtttgt tgggtgttaa gtcagaagaa atctttttta
     7321 cgtctggtgg gactgaaagt gctaattggg ctattaaggg aattgctttt gaaaaaaccg
     7381 cttttggcaa acatattatt atctcagcca ttgaacaccc tgccgtgagt gaaagtgtca
     7441 aatggcttct cacacaagga ttcgaagttt cttatgctcc agtgacaaca cagggagttg
     7501 ttgatgtgaa tgctttagct gagctgatta gaccagacac catcttaatc tcgattatgg
     7561 ctgttaataa tgaaatggga gctatccaac cgattagagc catttcaaac ctattggcta
     7621 accaaccaac gatcaccttt cacgttgatg ctgttcaagc cattggtaaa ataccactct
     7681 gtgattatat gactaatcgt gtggatttgg cttctttttc agggcacaaa tttcatagtg
     7741 ttcgtggtgt tggcttcctt tataaaaaag caggcaagcg actcaatcct ctcttgtcag
     7801 gcggcggcca agagcaggag ttacgttcaa ccactgaaaa tgttgcagga attgctagca
     7861 tggccaaagc attaagaata gtcactgaaa aacaagtgag cgtcttacct aaactaacag
     7921 cgatgcgaga tgtgatttac aaagctttgt ccgcttaccc agatgtgaca gtattttcag
     7981 ctcaagaagg ctttgcgccc aatattttga cctttgggat tagaggggtt cgaggagaag
     8041 ttattgtcca cgcctttgaa aaatatgaga tttatatttc gaccacaagt gcatgttcgt
     8101 ccaaagcagg taagccagca ggaagcctag tggctatggg ggttcctgta aaaactgccc
     8161 agacagccgt tcgtattagt ctagacgatg acaacgatat gggacaagta gagcagtttt
     8221 tgaccatatt caaacagatt tatgataaaa cacagaaagt taggtaagat taggtaagat
     8281 ggactattca gaaattatgg ttcgccatgg tgaactatca actaaaggga agaatcgcat
     8341 gcgattcatt aacaaactta aaaacaatat tcaagacgta ctggctcctt tcccagccat
     8401 tactgtccgt tcagatcgtg ataggaccca tgtgtctcta aatggcacag attatcagcc
     8461 tattgtagaa gctttaaagc tggtgtttgg tgttcaagct ctatctcctg tttataaact
     8521 tgaaaaaagt gtccctcttt tggtaacagc tgttcaagat atcatgactt ctctttatcg
     8581 tgatggactg acgtttaaga ttgccactaa gcgtagtgat cacgcgtttg aattggatag
     8641 tcgtgagctt aacagccttc ttggtggagc tgtttttgag gttttaccca atatccaagc
     8701 ccagatgaaa catcccgatg tgactctcaa agtcgaaatt cgtgatgaag cagcttacat
     8761 ttcttatgaa gagattaagg gagcaggcgg gttaccagta ggaacgtcag ggaaagggat
     8821 gctgatgtta tcgggcggta ttgattcacc agtagctggg tatttagccc ttaaacgtgg
     8881 ccttgatatt gaagttgttc attttgctag ccctccgtac accagtccag gtgccttggc
     8941 taaagcccaa gaccttactc gtcggttaac tcgttttggt ggaaatatcc aatttatcga
     9001 ggttcctttt acagaaattc aagaagaaat taaaaataag gcaccagagg cttaccttat
     9061 gacattaacc cgccgcttta tgatgcgcat cacagatgcc attcgtgagc aacgtaaggg
     9121 tcttgttatt gttaacggtg agagcctagg tcaggttgct agtcaaaccc ttgaaagcat
     9181 gcaggccatt aatgcggtaa cctcaacccc aattattaga ccagtcgtga caatggataa
     9241 acttgaaatt atcgagatgg ctcaggcgat tgatactttt gacatttcta ttcaaccgtt
     9301 cgaagattgc tgtactattt ttgcaccaga ccgtcctaaa accaacccta aactaagtaa
     9361 tgctgaaaaa tatgaagaac gctttgatat tgatggtctt gtccagcgtg ctgtgtcagg
     9421 aattgttgtc acagaaatca cacctgaaat cgtcaatgat gaggttgaaa atctcattga
     9481 tgctttactt taaaagaaaa gatcaagtgt aaatctttta gtagtcagta atgatactat
     9541 tgaaaagcct ctataagggc ttttttgctg caatgaagga ggaaaatttt gaggcaagat
     9601 gttataatag agaaaaagga gggtgtgtct tgattaaaac tatgcaatac aaaaaaacga
     9661 tggcaacagt tgttgctctt atcgtcgcac ttttgctatt tggcttgatt tatgatttac
     9721 ttggggttca aaaaaatgag ctagcagctc aaaaatctgc tcagccaaag gtcaaagcag
     9781 cgcgtgttgt agctaatggc gacattttaa ttcatgatat tctctacatg agtgctagaa
     9841 aagctgacga tacctatgat ttcactcctt attttgaata tgttaaggac tggattagcg
     9901 gtgctgactt agctattgga gattatgaag ggaccattag cccagattat cccttagcag
     9961 gctatccctt attcaatgct ccagaagaga ttgcaggtgc tctgaaaaat actggctatg
    10021 atgtagtcga tttagcccat aatcatatct tagattccca attagacggt gcccttaaca
    10081 ctaaaaaggt ttttcatcaa ttaggtatag acagtattgg catctatgac aaggatcgtt
    10141 caaaagaatc cttcttaatt aaaaatgtca atggtatcaa aattgcaatt ttaggttatt
    10201 cttatggtta taacggcatg gaggccacac ttagccaaga agactatgag aaacacatgt
    10261 ctgatttaga tgaagctaag ataaaaaaag aacttcagct agctgaaaaa aaggctgacg
    10321 tgaccattgt catgccacaa atgggaacag aatatgcctt agaaccgaca gcagagcaaa
    10381 aagaacttta ccacaaaatg attgattggg gagctgacgt cgtcctagga ggccatccgc
    10441 atgttattga accttcagag acagttataa aaggtaggca aaagaaattc attatttact
    10501 ctatgggaaa ttttatttca aatcagcggc ttgaaaccgt agatgatatc tggactgagc
    10561 gtggcctatt gatggacctt acttttgaga aaaaagataa caaaacaaaa attaaaacag
    10621 ttgaggccca tccaaccatg gttttagcca aaggtaaagg tattgtgggt aaagaaggtt
    10681 ttgaactata caattatcga acaatggttt tagaagattt tatcaaaggt ggaaaatacc
    10741 acgacaagat tgatgaggaa accaaagcaa aagtagcact tgcttatcag gaaattaatg
    10801 atttagttaa cctgaaatgg taatgtttgg tggtttagca tctaatggcc aaatttcaag
    10861 ttgaagttag ccagttttaa catttctact ggcgacttgt agttgaagag tcgtttagga
    10921 taatgattga tccaatgttc aatagcagcg acttctttag gggtcgttgt tttggtacct
    10981 ttagagagcc atctgagaat aaggcgatta tggttttcgt tagtgcctct ctcccatgac
    11041 gcatagggat gggcgtagta gatggcactt gctggaacga catctgataa gcaagaaaat
    11101 tctgtcccgt tgtctgctgt gatagagttg acggtgtagt cttttagaat ccccgtaaga
    11161 gcttcattga cggcttgagc agacttatcc ggtattaatc gaatcagctg atgacgtgtt
    11221 ttcctgtccg ttagggtgag taagcattga tttttagccc tcgtcagaat gactgtatca
    11281 atctcataat gcccagcttc aagacgttgg ttaatgctat ctggacgttg ttcaatactc
    11341 tttcctgcgg gtttaaaata aggactggct tgttttctag cctgcttagc ctttctcgga
    11401 taaagcatag cctccttacc aaggcttaat ttgccatgat gaatccagta atagatggta
    11461 gatacaggga cttgaactcc cttagcttta accatcatct caggggaata attctgatgc
    11521 atgtagtgtt caatagcctc cctatcttgc ttacgctgcc taatgggtct aacagaacgc
    11581 ttgcgatttt cttgatagat caactgagta tgttgagcag aataaacggc ttcaaacttt
    11641 cctttacgaa cctgttgcct aagcaagcct cgcttgattt cattatgatt ggtctggggt
    11701 gccttaccta gtaagcgagc aatttcaccc cgttctgtgg ctgaaagatg agaataggag
    11761 gattttctgg tagaattaat attagacatg ttcatctgct ttccatactg aattgaggaa
    11821 ttctagtata tcagacgaac atgtcttttt tgttgcactt cattttacaa cgcgggaatg
    11881 ataaaaaata gagattaaac ttaatttttc cttgataaaa agcagttatg gtgctaaaat
    11941 agtaacgttg actaaatgca catcctgtgc aaccgcgcga aaatcgttat caagtagacc
    12001 aagtctcacg attccaggcg agtcttcaca gagggaaacc tcaaacaaaa attttatagg
    12061 aggtgcatca tgagcacata cgcaatcatc aaaactggtg gaaaacaagt taaagttgaa
    12121 gtaggtcaag caatctacgt tgagaaaatt gacgctgaag ctggcgcaga agtcactttt
    12181 aacgaagttg ttcttgtagg tggtgacaaa actgtagttg gtactccagt tgttgaagga
    12241 gctactgtcg ttggaactgt tgaaaaacaa ggaaaacaaa agaaagttgt aacattcaaa
    12301 tacaaaccta aaaaaggtag ccaccgtaaa caaggtcatc gtcaacctta cactaaagtt
    12361 gtcatcaacg caatcaacgc ttaatttact agcttatgat taaagcaatt tttactcgcc
    12421 aaaaaaatgg tcaactgagc agtgttacac tgacaggtca tgctggtagt ggtaaacatg
    12481 gctttgatat tgtttgtgcc tctgttagta ctctagccat taactttgtt aattctcttg
    12541 aggtgttagc agattgccaa gcattagtag atcttaatga tgttgaaggt gggtatatgg
    12601 ctattacaat accaccacat gacaacaagg aggaagttca attattattt gaatcttttc
    12661 ttctaggaat gactagtttg gcgaaggatt cttcgaaatt tgtcaacact caggtcatct
    12721 aaatttaatt taagagagga aacaacatta tgttaaaaat gaatcttgct aacttgcaac
    12781 ttttcgccca caaaaaaggt ggaggttcta catcaaacgg acgtgactca caagctaaac
    12841 gccttggtgc taaagctgct gacggtcaaa ctgtttcagg tggatcaatc ctttaccgtc
    12901 aacgtggaac tcatatctac ccaggtgtaa acgtaggccg tggtggagat gacacacttt
    12961 ttgctaaagt tgaaggtgtt gtacgtttcg aacgtaaagg acgtgataaa aaacaagttt
    13021 ctgtttaccc agtagctaaa taattgttta acatcgcatt atataaggct ttccaggtgt
    13081 ctggaaagcc tattttttta ttttggtact catgttgcta cccatatttt aaaaatcaat
    13141 gtaggaagag agcttgtcag cagttttatc ttttgaggat ttagtaacat gagcgtagat
    13201 gttcatggta gtttggatag tttcatgacc aagtgtattg gattttcatt gtttgtttct
    13261 atcctactaa agattgtagt tgcttattta gagcaatagt tctaattgta aaaagtcagc
    13321 ataataaaac aatgtcataa gatgttgtta taacgggctt tatggtataa ttaaggatac
    13381 tcattttagg aaggaaagca atgaatattc aacaattacg ctatgtggta gccatcgcta
    13441 ataatggaac ttttcgagaa gctgcctcta aattgtttgt cagtcagcct agcttatcag
    13501 tttctatcaa agatttagag gcggaattag ggtttcaaat ttttaatcgg actacttcag
    13561 gaacagtctt gacaagtcaa ggactagttt tttatgagaa agctttagaa gtagtcaaat
    13621 cttttgattc ttttgaaaaa accttttctc aagctgatct ggatcaaaat gaattttcta
    13681 ttgctagcca acattatgac tttttgccac ctcttattac agctttttcg caacaatacg
    13741 atggtcatcg tgtctttcgt atctttgaat caacaactat tcaaatttta gatgaggttg
    13801 ctcaaggaaa cagtgaaatt ggtattattt acttgaatgt agacaatcaa aaaggcctct
    13861 ttcagcggat ggataagctg ggcttggaat atgtttctct aattcctttt actactcata
    13921 tttatctttc aaaaacgcat ccattggcta atcgcgaagc gctttatttg agtgatattc
    13981 aaggattacc tgcggtaagg tttacccaag aaggggacga gtatttgtat tattctgaaa
    14041 attttgtgga tactagtgaa tgccctcgta tttataatgt gtcagatagg gcaaccttga
    14101 acggtatttt agagagaacc aatgcctttg cgacaggatc aggttttctc gatcatcgga
    14161 gtgttaatgg gattaaagtg atacctctag ctgatcatat tgacaatcaa atgatttatg
    14221 tcaaacgaaa agataaaaac ctttctgttg ctggggccac ttttgtgact attttaaaag
    14281 actattttga taaaagaagg aaggccttaa catgaaaaaa cgattgtttg tgcttagctt
    14341 gatcctcctt gtagctttgg atcaacttag taaattttgg attgtttctc atatagcgct
    14401 tggagaagtg aaacccttta tcccaggtat cgtcagcttg acttacttgc aaaacaatgg
    14461 ggctgccttt tccatattgc aggaccagca atggttcttt gttgtcataa cggttttagt
    14521 tatcggttat gctatttatt accttgctac tcatccccat ttaaatatct ggaaacaatt
    14581 agctctcttg cttattattt ctggtggaat cgggaatttt attgatcgtt tgcgtttagc
    14641 ttacgtgatt gatatggttc atttagactt tgtggatttt gccattttta atgtggcaga
    14701 ttcatacctt accgttggtg tcatattatt agtgatatgt ttatggaaag aagaggatta
    14761 tggaaattaa tgtgataaca tcggggcaac gcttggataa ggcactagct gatttaagtc
    14821 ccctgtcacg tggtcaagcc aatgaccaaa ttaagcaagg ccttgtttta gttaatggtc
    14881 agcaaaaaaa ggctaaatat acggttcaag caggagatgt gatttgtttt gaactcccta
    14941 aagaagaagt cttagagtac caagctcaga atattccctt ggacattatc tatgaagatg
    15001 atactctcgc cattattaac aagccacagg gaatggtagt tcacccttcg gcgggacacc
    15061 cttcaggaac aatggttaat gccttgatgt atcatatcaa ggatttgtcc tcaatcaatg
    15121 gtgtggttcg tccaggaatt gttcatcgga ttgataagga cacctcaggt ctcttaatgg
    15181 tagctaaaac agatgcagct catcaagcct tggcagaaga attaaaggct aaaaaatctc
    15241 tcagaaaata cctcgccatt gtccatggaa acctaccgaa tgatcgcggg atgattgaag
    15301 ctcctatagg tcgtagcgaa aaggaccgta aaaaacaggc tgttacagca aaaggcaaag
    15361 aagcagtgac acgttttaca gtgctagaac gttttggcga ttacagtcta gtggaattac
    15421 aactggaaac tggtcgaacg caccaaattc gtgttcatat ggcctatatt ggtcatcctg
    15481 ttgctgggga ccctttatat ggaccacgta agacactatc aggtcatggc caatttcttc
    15541 atgcaaaaac attgggatta acgcatccta tgacaggaaa agaaatgata tttactgttg
    15601 aagctcccga aatttttcaa aaggtgttaa agctgctaag aaaaaaataa acagcgagga
    15661 gtagccatta tttttagtct tatatctttg tgtaaagttt ttaacattat aaaaaatact
    15721 aaaaagcatt tacgataagc caggaaatat gagaagtctt ttatgttatt gggatatgca
    15781 acatatctgt tagagatctt tatttaaact cttaaagaaa agagatattc caaatagatg
    15841 ctaggtattg tcttttttac ttgtttttct tttctttttt tgctatactg attgaaataa
    15901 aatattcctt taaaacagtc ctgtgaggct gtcaaggaga cggattaaaa acatgcacta
    15961 tgatacttaa ttgtgctata ttttgctgaa tctccttgtt tccaaggaga tctttttatt
    16021 tgaattttta gaggaggttt caacatgaaa actaaggaaa ttgttgatga cgtgaccatg
    16081 aaacgcgcca ttacccgtat tacttatgaa attattgaac gtaataaaca attagacaat
    16141 gtggttttgg caggcatcaa aacgagaggt gtttttctag ctcgtcgcat tcaagaaaga
    16201 ctgcatcaat tagaagggtt ggatttacca attggtgagt tagacatcaa gccttttaga
    16261 gatgacatga gagttgagga agacacaact ctgatgtcag tagatattac aggcaaggat
    16321 gtgattttga ttgatgatgt gctttatact ggtcgtacca tccgcgcggc catcgataac
    16381 ttagtgagtt taggtcgacc agcccgtgtt agtctagctg ttttggtgga tcgtggccat
    16441 cgggaattac cgattcgcgc ggattacgtt gggaaaaata ttccaacaag cagtgtagaa
    16501 gaaattgttg ttgaggttgt cgaagttgat ggccgtgatc gtgttagcat tattgaccca
    16561 acataagaag gaggttttac tgtgaaagat gtcatttatg atgtggaaga agtgccaaag
    16621 gcaggtatgt tagttggttt gtcctttcag catttatttg ccatgtttgg ggcgacggtt
    16681 cttgttccta ttttagttgg aattgacccg tctgtggccc tcctatcgag tggtttagga
    16741 acacttgcac atttatcggt aaccaaattt aaaattccag cctacatggg ctcaagtttt
    16801 gcttatatag cagctatgca gttactgatg aagacaaatg gtattggtgc tgtagctcaa
    16861 ggggctatga caggaggtct cgtttacctg attgtagctt tgattgttaa agttattggc
    16921 aatgattgga ttgataagat tttaccaccg attgtagttg gtccgattgt tatggtcatt
    16981 ggtctaagtc tagcttctac agctgttaat gatgtcatgt taaaaaatgg gaactataat
    17041 ctgacttatc ttgttattgg gttagtcacc ttattatcag ttattttttt caatatttat
    17101 ggtaagggaa ttgttgctat tgtaccgctt ttattagggc tattagttgg ttatgttgta
    17161 gcccttttag tgggtgttct caccggtcaa gaaattgttg attttaccaa tgtggctcag
    17221 gccaaatggt ttagtatccc atcagtggaa attcctttct taacctacgg ggttaaattc
    17281 tacccaagtg ccattttaac tatggcaccc attgcctttg ttacaatgac agaacatttt
    17341 ggacacatta tggtcttaaa tagtttgaca aaaagagatt atttcaagga tccaggactt
    17401 gaaaagactt taactggtga tggttttgcg caaatcattg ccggcttctt aggggcacct
    17461 ccggtcactt cttatggtga aaacatcggt gtaatggctc tgaataaaat attctcggtc
    17521 tatgttattg caggtgccgc agtgattgcc gctctcctca gttttatcgg taaggtatca
    17581 gccttaattc aatctattcc aacaccagtt attggaggta tatcagttgc cttgtttggt
    17641 gtgatagctt ctagcggttt gaaaatcttg attgaatcca aagttgatat ggataataag
    17701 aaaaacttat tgattgccag tgtcattttg gtctctggga ttggaggatt gatgcttcaa
    17761 gtaaatggtc ttcaaatttc aggtgtcgct ttctcaacac ttcttggcat catcttatat
    17821 caggtacttc ctgaaaaata ggaagaattg ttgttagact acttacatag tcatcagtcg
    17881 ttagtgataa aggggataat catgtcagtt gtaaataatc gcgttgcact taccaattta
    17941 gtttcaatgg aagcattaac caccgaagaa gttttaggtc ttatcaaccg tggttcagaa
    18001 tataaggctg gtaaggttgt tatttcggat catcaaaagg atcttgttgc caatttattc
    18061 tttgaaaact ccacccgaac ccataagtct tttgaagtgg ctgagaagaa actcggcttg
    18121 acagttcttg atttcaatgc tgatgcaagt gcggttaaca agggagaaag tttgtatgat
    18181 actgtgttaa ccatgagtgc acttggaaca gacatctgtg tgattcgtca cccagaagat
    18241 gattattaca aggaattagt agaaagtcca actattacag cttccattgt caatggagga
    18301 gatggttctg gacaacaccc gagtcaatgt ttacttgact tattaaccat ctatgaagaa
    18361 tttggacgct ttgaaggctt aaagattgcg atcgctggtg acttaactca ctctagggtg
    18421 gcaaagtcca acatgcaaat cctcaaaaga ttaggagcag agctttattt ctatggacct
    18481 gaagaatggt attcagaagc ctttaatgct tacggcactt atattgctat tgaccagatt
    18541 attaaggaat tggatgttct tatgttgctg cgtgtacagc acgaacgtca tgacggccat
    18601 cagagttttt caaaagaaag ttaccatcaa gcgtttggat tgacacagga acgttaccaa
    18661 caattaaaag attctgctat tattatgcat ccagctccag ttaatcggga tgtggaaatt
    18721 gcagatagtt tggtggaagc tcctaaagcg agaattgtat ctcagatggc taatggtgtc
    18781 tttgttcgca tggctattat tgaagccatt ttgaatggta gaaataaaaa ctcatgatga
    18841 aagattaaag catgtttaga aggtaggaaa aggtaggaaa atgacaaaac gattacttat
    18901 tttagaagac ggcactattt ttgaaggaga accctttggt gctgatattg atgtgactgg
    18961 tgaaattgtc tttaatacag gaatgacagg ctaccaagaa tccatcactg accaatccta
    19021 caatgggcaa attttaacct ttacctatcc tttgattgga aattatggga ttaatcgaga
    19081 tgactatgag tccatttcac ccacctgtaa aggggttgtt gtgtccgaag tcagtcggtt
    19141 ggcaagtaat tggcgcaagc aaatgacgct agatgcgttc ttgaaaataa aagggattcc
    19201 agggatttcg ggaattgata cgagagcttt gaccaaaatt attcggcaac acggtaccat
    19261 gaaagctacg atggcagatg atggagatag tatccagcat ttaaaagatc aactgcgtgc
    19321 aacagtctta ccgactaaca ccattgaaca agtgtcaact aaaacagctt atcctgcacc
    19381 agggatcggg aaaaatattg tattggttga ttttggttta aaacattcta ttttaagaga
    19441 attttctaaa agacaatgta atatcaccgt tgtccctttc aacatcactg cagaagaagt
    19501 gctccaacta aatccggatg gcttgatgct atctaatggc ccaggaaacc cagaagattt
    19561 gccagaggct ttagacatga ttcgtggggt acaaggtaag attcctattt ttggtatttg
    19621 tatgggacat caactcttta gtctagcaaa tggtgctaag acttgtaaaa tgacctttgg
    19681 tcatcgtggc tttaaccatg ccgttagaga aattgcaacg ggaagaattg attttaccag
    19741 tcaaaaccat ggttatgccg ttgaacgtag tagtctacct gatactttaa tggttacgca
    19801 tgaagacatt aacgataaga cggtcgaagg agtgaaacat agagattttc cagctttttc
    19861 agtccaattt caccctgatg cggctccagg acctcatgat gccagctact tatttgacga
    19921 atttttggaa atgattgatt cttggagatg tacgagtaaa tagtaaatca gttgcaattt
    19981 cacgactata tcacctcttg ttactctatt tattaacatt tacagttgat ttagtaccct
    20041 atcaaaaata ttatttaatg ttgctctgtg aggcaacaaa tagagaaagg aaggcaagga
    20101 gaacacaagt aaataattta gtaaaaagtt aggttttcaa agagataaag ctcttattga
    20161 gaagtgctga ctttaccgct tcttgtggta ttcttggtat cattaattat gccaaaacga
    20221 aaagatattc aaaaaatcat ggttatcggg tctggcccga ttattattgg acaagctgct
    20281 gaatttgatt atgcagggac tcaggcctgt ttggctctaa aagaagaagg ctacaaagtc
    20341 atacttgtta attcaaatcc tgcaacgatt atgacagata aagaaatcgc tgataaggta
    20401 tatattgagc ctttgactct tgaatttgtt aatcgtatca ttcgaaaaga aaggccagat
    20461 gccatactgc caaccttagg tggccaaacg ggcctcaata tggcaatggc gttatctaaa
    20521 gctggtattc ttgatgattt agagattgaa ttgttaggta ctaagttatc tgcgattgat
    20581 caggcagaag acagagacct tttcaaacaa ttaatgcaag aactagacca acccattcca
    20641 gaatctacaa ttgttaaaac agttgatgaa gctgttacat ttgctagaga tatcggttat
    20701 ccagtcattg tgcgcccagc ttttactctt ggtggaactg gtggaggaat atgtagtagt
    20761 gaagaagaac tttgtgaaat tactgaaaac ggcctaaagt tatcaccagt cacacagtgt
    20821 ttgattgaac gctcaattgc tggcttcaaa gaaattgaat acgaagtaat gcgagatagt
    20881 gctgataacg cgctggttgt ttgtaatatg gaaaactttg atcccgtagg gattcacaca
    20941 ggagattcta ttgtatttgc accaacacag accctttctg atattgaaaa tcaaatgtta
    21001 cgtgatgcta gtttaaaaat aattcgagct ctgaaaattg aaggtggctg taacgtccag
    21061 ttagcactag atccttatag tttcaaatat tatgttattg aagtaaatcc tagagtgtct
    21121 cgttcctctg cccttgcttc aaaagcaaca ggttatccca ttgccaaatt ggctgcaaag
    21181 attgctgttg gcctaacact tgatgaaatg attaacccta tcacaggcac tacttacgct
    21241 atgtttgaac ctgcccttga ttacgttgtt gctaaaattc cgcgttttcc gtttgataaa
    21301 tttgaacatg gtgaacgcca actgggaact caaatgaaag caacaggtga agtcatggct
    21361 attggccgta atttggaaga gtccttacta aaagcctgtc gttctttaga aattggtgtt
    21421 tgccataatg agatgacaag tttaagtaac attagtgatg aagagttagt gactaaagtg
    21481 attaaagctc aagatgatcg acttttttac ttgtcagaag caatacgacg aggttatagt
    21541 atcgaagaac ttgagagctt gaccaagatt gatttatttt tcttggataa attacttcat
    21601 attgttgaaa tagagcaaga attacaaatg catgttgacc atttggaaag cctcaaaaaa
    21661 gcaaagcgtt atggattttc agatcaaaaa attgcagaaa tttggcaaaa ggatgaaagt
    21721 gatatcagag cgatgagaca ttctcatagc ctgtatcctg tctataaaat ggtagatact
    21781 tgtgcagctg aatttgatgc taaaacccct tatttttatt caacatatga gttggaaaat
    21841 gaatctgttc agtcgaataa agaatcaatt ttagttttag gttcaggccc tattcgtatt
    21901 ggtcaagggg ttgaatttga ctacgcaacg gttcattctg ttaaagccat ccaaaaagct
    21961 ggctatgaag ccattatcat gaattcaaat ccggagactg tatctacaga tttttcggta
    22021 tcagataaat tatattttga accgttaacc tttgaagacg tcatgaatgt gatagattta
    22081 gagcagccta agggagtaat agttcagttt ggaggacaaa ctgctattaa cttagcacaa
    22141 gcactttctg aggcgggtgt tacaatatta ggaacacaag tagaggattt ggatagggct
    22201 gaagacagag atttatttga aaaggcgttg aaagagcttg gaatcccaca accacaaggt
    22261 caaacggcaa ctaatgaaga agaagcttta gaggcagcta aaaaaattgg ttttccagtc
    22321 ttagttagac cttcttacgt acttggtggc cgggctatgg aaattgttga aaacaaagaa
    22381 gatcttatag aatatataag aacagcggtt aaagcaagtc ctgaacatcc tatcttagtg
    22441 gactcttata ttttcggtaa ggagtgtgaa gtggatgcca tttcagatgg aaaatcaatc
    22501 ttaattcctg gtattatgga gcacatcgaa agagcaggtg ttcattcagg agattcaatg
    22561 gcagtttatc cgccacagca attatctaag caaattcaag aaacaatagc tgagtatact
    22621 aaacgtttag ccattgggtt aaattgtatt ggtatgatga atgttcaatt tgttattaaa
    22681 aatgaacaag tctatgttat tgaagtgaat ccacgcgcta gtcgtaccgt gcctttctta
    22741 tcaaaagtaa caggtattcc gatggctcag attgctacta agttgatttt aggtcaaaca
    22801 ttaaaggatc taggatatga agatggtctt tatccccaaa gtcaactggt gcatatcaaa
    22861 gcgcctgtgt tttcatttac aaagttggca caggttgata gtcttttagg tcctgaaatg
    22921 aaatcaactg gagaagtaat gggttcggat actagtcttg aaaaagcact ttataaagcg
    22981 tttgaagcca ataattctca tttatcagaa tttggtcaaa ttgtctttac tatagcagat
    23041 gatagtaagg cagaagctct aagtctagca agacgattta aggcgattgg ctatcaaatt
    23101 atggctactc aaggtacagc agcttacttt gctgagcaag gcttaagcgc gtgtttagtt
    23161 ggaaaaattg gtgatgctgc caatgacatc ccgacactcg tgcgacatgg tcacgttcag
    23221 gcaattgtta atacagttgg aattaaacgc acagctgata aagacggaca gatgattaga
    23281 agttcagcta ttgaacaagg agttccttta tttacagctt tagatactgc aaaagctatg
    23341 ttaacggttt tagaaagcag atgctttaat atcgaagcga tataaaaatt aaaaaatcat
    23401 ttttaagaaa acttaaaaat gattttttag attataatga caaaagtttc agtaagctat
    23461 taatttgtca tagcatataa gtcattatct tgtggcttgt tttcgactaa gggctaagaa
    23521 tttcttgaca acaatataaa aaggtcatat acttgtctta tacaaatagt acaaaagggg
    23581 aggatagaaa tgtctaaaag aggaaaaatt aaaataacaa cgaaaacaaa gcttattaca
    23641 gctagtgtta taacgctagt attaattata actggagtag tcttgtggaa acaacaacaa
    23701 aatacgctaa cagctgatat cgctaaagaa ccttactcta ctgttagtgt aactgaaggg
    23761 agtattgctt cttcgacttt actctcaggt actgtaaagg ctttatcaga ggaatatatt
    23821 tattttgatg ctaataaagg aaatgatgca actgttacag ttaaagtagg tgatcaggta
    23881 acgcagggcc agcaattagt tcaatataat acaacaacag ctcagtcagc ttatgatact
    23941 gctgttagga gtcttaacaa gattggccga caaattaatc atcttaaaac atacggagtt
    24001 cctgctgtta gtacagaaac taataaagat gaagctaccg gtgaagagac gacaacaaca
    24061 gttcaaccat cagctcagca aaatgctaat tataaacagc agctgcaaga tttaaatgat
    24121 gcttatgcag atgcacaagc agaagtaaat aaagcgcaga tagcgttaaa tgatacagta
    24181 gttatcagta gtgtctctgg aactgttgtg gaagtaaata atgatattga tccttcttca
    24241 aagaacagtc aaacacttgt tcacgtagca accgaaggac agcttcaggt gaaaggaaca
    24301 ttgacagagt atgatttagc aaacgttaag gttggtcagt ctgtaaaaat taagtctaaa
    24361 gtttattcta atcaagaatg gactggaaaa atatcatatg tttcaaacta tccaactgag
    24421 tctaatgcag gttcaacaac gccagcaggt agcactggag cgggaagttc tacaggagct
    24481 gcctatgatt acaagattga tattataagt cctctcaacc agcttaaaca aggcttcact
    24541 gtttctgttg aggttgttaa tgaagcaaaa caggccttag ttcctttaac ggctgttatt
    24601 aagaaagata aaaaacacta tgtttggact tatgatgatg ctactggcaa agccaaaaaa
    24661 gtagaggtga cacttggaaa cgcagatgca caacaacaag aaattcataa aggagtaact
    24721 gttggtgaca ttgttattgc caatccagat aaaaatatca aaccggataa aaaactagaa
    24781 ggggttattt caataggtac caacacaaaa ccggaaaaag attctcaatc aaagaataaa
    24841 aaatcagggg tggataaata gtgtcgcatg aaaaaaaaca attaatgcaa ttatcaaata
    24901 ttgtgaagag ctatcaaaat ggggatcaag ttcttaaagt tttgaaaggt attaatttaa
    24961 cagtatatga gggtgaattt ttagctatta tgggtccgtc tggttcggga aaatcaacac
    25021 taatgaatat tattggttta ttagatcggc caacatccgg agattacaca ttacataata
    25081 ctaaaataga aatccttaat gatcgtgaat tagcaaaagt acgaaatgat gaaatcggct
    25141 ttgtctttca acaattcttt ctgttagcta aattaactgc attacaaaat gttgagttgc
    25201 ctcttattta tgctggtgta aacgtctcaa aaagacgtga acaggctaag caatttcttg
    25261 aaaaagtagg acttggacga cgtatcaaac atctaccgtc agaactgtca ggaggtcaaa
    25321 agcaaagggt ggctatcgca cgagctttag taaatgaccc atctattatt ttagcggatg
    25381 aaccaacagg tgcactagat actaaaacag gtcagcaaat tatggaactc ttgacagagt
    25441 taaacaaaga aggtaaaaca attattatgg ttactcatga accagaaatt gctgattttg
    25501 caactcggaa aattattatt cgtgatggtg atatcacaac ggatactaca gctagtgttg
    25561 ttattgacta ggaggaaaaa taatggaaaa ttggaaattc gctcttagct caatttgggg
    25621 gcataagatg cgctcaatcc tgacaatgtt gggaattatc atcggtgtag cagcagttgt
    25681 gattattatg gggttgggaa atgctatgaa aaatagtgta acaagcacat tttctagcaa
    25741 gcaaaaagat attcaactct attttcaaga aaaaggagaa gaagaagacc tgtatgccgg
    25801 attgcacacg catgaaaata atcacgaagt gaagccagag tggttagaac aaattgttaa
    25861 agatatcgat ggtattgatt cttattactt taccaattct gctacttcta ctatttcgta
    25921 tgaaaaaaag aaagtagaca atgcttcgat cataggggta agtaaagatt attttaatat
    25981 aaaaaactat gatatcgtag ctggtcgtac actaacagat aatgattatt ctaatttttc
    26041 gcgtatcatt cttttagata cagtattagc cgatgaccta tttggcgaag gtaattataa
    26101 gtcagcttta aataaagtgg taagtttatc tgataaagat tatttagtta ttggtgttta
    26161 taaaactgat cagacgccag tttcttttga tggattatca ggcggcgctg tcatggcaaa
    26221 tactcaggta gcttcagagt ttggcaccaa agaaatagga tctatctaca ttcatgtgaa
    26281 cgatattcaa aacagtatga acttaggaaa tcaagcagct gatatgctaa ccaacatatc
    26341 gcatattaaa gatggacagt acgctgttcc tgataatagc aaaatcgttg aagaaatcaa
    26401 tagtcagttc agtatcatga caacagtcat aggttcaatt gcagcgatct ctcttttagt
    26461 gggaggaatt ggtgttatga atattatgtt ggtatctgtc acagagcgaa ctagggaaat
    26521 tggtttacgt aaagcacttg gtgcaacacg cctgaaaatt ttatcacaat ttttgattga
    26581 atccgttgtt ctaacagttc ttggaggctt gataggatta ttattagctc aattaagtgt
    26641 aggggcttta ggaaatgcga tgacattaaa aggagcttgt atttctcttg atgtggcctt
    26701 aatagcagtt ttattttctg cctcaatagg tgtctttttt ggaatgttgc cagctaataa
    26761 agctagtaag ttagatccaa ttgaggcatt acgttatgaa tagaatagtt cgtatcaatt
    26821 aatctataga cgctgactag tttaacgtct gattatatct attttttgta ttagcacagt
    26881 agttatatca ttgaagtgtt agtgcatttt ttgaggtgat aatatctagc aaagctatca
    26941 ttggtatgat gatgtggata gcgtataagt gatacatctc ttatttctag ctgaacttcg
    27001 gttcggctag gaagttgtca ggcaatgagt tgtttaaaat aaaggagatt agttcaatga
    27061 catttttatc tgatttgata tcattaatga caaaaatcag attatcttgg gtaataaagg
    27121 cgggtatttt tcaattatta tttgtaacga ttgctaatat tgtcttatca gaatttttct
    27181 attttatatt agacgttact ggtcaatatc atttagataa agacaatgtt gtgacttttt
    27241 taaaaaatcc tatagcactt gctttattag gtgcctattt atttttatta gctgctttta
    27301 ttcaccttga gttttttgct ctatatcgaa ttattgcgga tcaagaaatt agtttctatc
    27361 tttttagaaa acagttttct tattacctaa gggggctttg gaaaacattt tctggttacc
    27421 aattattact ttttttgctt tatatcctac tgactattcc agtcttacat attggtttat
    27481 cttctgtgat tactcaaaag ctttatcttc cagaatttat tgttggggaa ttatcaaaga
    27541 taactagcac aaagtacttg ctttatggca gtcttattct tgtgttttac cttaacctaa
    27601 gattagtata ttttttacca ttgatagcaa tcaaccatcg tacggttgct caagcatgga
    27661 gagagagttg gcaaaagact aaaaagaaac atgtattgtt atggatgaaa ctttttgcaa
    27721 tcaatggtct tacgcttgta gtcttatcgc tagctatttc catgattctt atttttgttg
    27781 atatgtttaa tcctaagggg aataatatta ttgttcagct gggagctttg acctttacat
    27841 gggagctcat tttttttact actatttttt ttaaactctg ttcagcaatg attttaaaag
    27901 aggcaattga accacaaaag caatatgatg agccaagaag aagtaataag gcatatgttg
    27961 taatctttat cgtggtgaca gtaggttttg cttatcaatc tcttgaacgt ttaacttttt
    28021 ttgacacatc tcactctaag acagttatcg cgcatagagg acttgtatca gcaggtgtag
    28081 aaaattctct ggaagccctt gaaggtgcta agaaagcagg aagtgattat gtagaactgg
    28141 atctaatctt gactaaggat aatcactttg tggtgtctca tgataatcga ttgaagcgtt
    28201 tagctggagt aaataagacg attcgcaact taaccttaaa agaagttgaa catctaacga
    28261 gtcatcaagg acatttttca gggcgttttg tttcttttga cactttttat caaaaggcta
    28321 agaagttgaa tatgccatta cttattgaac tcaagccaat tggtacagaa cctggaaatt
    28381 atgtcgattt gtttttagaa acttatcatc gacttggtat aagcaaagat aataaagtca
    28441 tgtctttaga tttagaagta atagaagcta tcaagaaaaa aaatccatca attacgactg
    28501 gttatatcat accaattcaa tttggctttt ttggagatga atttgttgat ttctatgtca
    28561 ttgaagactt ttcttatcgg tcttatttgt cgtcccaagc tttttggaat aataaagaaa
    28621 tttacgtttg gactattaat gatcccaagc gcatagagca ttatctccta aagcctattc
    28681 agggaattat tacagatcaa ccagctttaa ctaatcaatt gattaaagac ttaaaacaag
    28741 ataattctta ttttagtcga ttagtcagaa ttattagtag tctttattaa aggtttaaag
    28801 aaagtgtcaa gaaaaaaact tgacactttc tttaaactga gttatactgt ttaacatagg
    28861 aatttagcgt agctgtattt cttatacatt actaaaagaa aagagactat ttaaaaatgg
    28921 cagtaaaaat ccgtttaact cgtatgggtt ctaagaaaaa acctttctac cgtattaatg
    28981 ttgcagattc acgtgcacca cgtgatggtc gttttatcga aacagttgga acatacaacc
    29041 cattagtggc tgaaaatcaa attactatta aagaggatcg tgttcttgag tggttatcta
    29101 aaggagcgca gccttctgat accgttcgta acatcttgtc taaagctggt gttatggcta
    29161 agttccacga ccaaaaattc tctaaataat aacagcctat ggataccatt gaaaatctta
    29221 ttatcgctat tgtgaaacct ttgatttcac aaccagataa tcttaccatt aaaattgaag
    29281 atactcctga ctttttagag tatcatcttg acttggatgc tcaagacatc ggtcgtgtta
    29341 tcggcaaaaa aggtcgaact attactgcga taagatcgat tgtctactcg gttccaacac
    29401 taggaaaaaa agttcgctta gttattgatg agaaataatc actaacttga gatggattga
    29461 aaagcttgtt gacttaaagt caacaagctt
//
LOCUS       DAUDWO010000027        25721 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.027, whole genome shotgun sequence.
ACCESSION   DAUDWO010000027 DAUDWO010000000
VERSION     DAUDWO010000027.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 25721)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25721)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25721
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.027"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            9..1160
                     /gene="dcm"
                     /locus_tag="VHC05_001151"
     CDS             9..1160
                     /gene="dcm"
                     /locus_tag="VHC05_001151"
                     /EC_number="2.1.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015081856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /protein_id="HEQ5402467.1"
                     /translation="MAENLSGNDIKYLRKKYNLTQKELADALGLQKFGDRTIRRWEAE
                     ETHPSKLEQSSIQSFFNSLKNPPFIISENLPFKMIDLFAGIGGTRLGFQLTNEVETVF
                     TSEWDKFAQKTYITNFGDTPEGDITQIDENTIPDHDILVAGFPCQAFSQAGKRLGFED
                     TRGTLFFDVARIIKAKRPKAFLLENVKNLKTHDKGKTYKIIISTLENLGYSTSTVLFK
                     ARDFGVPQNRERIYIVGFDKTCVNNFSEFRFPEPFHLETKLGNILQTDVDEKYTISDK
                     LWEGHQRRKAEHKTKGNGFGYSLFNADSPYTNTLSARYYKDGSEILIEQKGKNPRKIT
                     PREAARLQGFPEEFIIPVSDTQAYKQFGNSVCVPTIHEIAKQILAVLKK"
     gene            1274..1963
                     /locus_tag="VHC05_001152"
     CDS             1274..1963
                     /locus_tag="VHC05_001152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5402468.1"
                     /translation="MFSHGRLKQRRLEIKLSQTAIANQLNVHRSAYHNWENGRNTPNQ
                     KNLTALAAILDVPVTYFESEYNIVNNYLQLSPDNQLKAEEYVEELLLSQQTSNVIPLF
                     SVQVLSDIQLSAGLGEGFFDEFETETIYSDEEQYGYDIAAWIEGDSMEPVYKSGEVAL
                     IRSNGFDYDGAVYALSWNDSVYIKKLYRDEDGFRMVSLNKDYPEKFIPYEDEPRIVGL
                     VVGHFMPVEGV"
     gene            1966..2193
                     /locus_tag="VHC05_001153"
     CDS             1966..2193
                     /locus_tag="VHC05_001153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402469.1"
                     /translation="MKLKDILELGTYGFNPNCKVEIFCMDNFEERLENEGFDEILIPQ
                     NDDAKIYPYAFLIEDSILIAMTEVDDDINEC"
     gene            2316..3731
                     /locus_tag="VHC05_001154"
     CDS             2316..3731
                     /locus_tag="VHC05_001154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="HEQ5402470.1"
                     /translation="MGYIDYSIEPQSDIAFLDMKSFYASVECVDRGLHPLYTSLCVMS
                     RADNSAGLILASSPMFKKVFGKANVGRSYDLPFDINTRKFSYQNAWKQGLEVTPKYKS
                     FIEHWAKRTLIVPPRMDRYIEKNLEIQHIFQDYAAPDDILPYSIDEGFIDLTSSLSYF
                     ISDKSMSRKDKLDNVSAMIQRDIYSKTGIISTVGMSNSNPLLAKLALDNEAKKTATMR
                     ANWSYEDVETKVWAIPKLTDFWGIGSKTEIHLQKLGIHSIKELANFNPDILKKEFGKV
                     GVQLWFHANGVDESNVHEPYKPKSRGLGNSQVLPRDYRTQREIEIVLAEMADQVANRL
                     RSAHKKATVVSIHIGYSRTEMKKSINAQKKIDPANLPKTMVGHVLELFRKKYTSGAVR
                     QIGVSYGGFVDENFTLLSLFDDVEQIEKENRLQTAIDVVREQFGFLAIQKGTVLTEGS
                     RNIERSKLIGGHSAGGLEGLK"
     gene            3728..4095
                     /locus_tag="VHC05_001155"
                     /pseudo
     CDS             3728..4095
                     /locus_tag="VHC05_001155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254363.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            4082..4381
                     /locus_tag="VHC05_001156"
     CDS             4082..4381
                     /locus_tag="VHC05_001156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402471.1"
                     /translation="MNQLEFQRNHLQMDYYSESYQDFERDFYRYSNMNIPLTFLTDDI
                     LKTMATSRKNYFVLNKEKSRDNRDHFFIFEVRTLEENPLIYHYTYKKTTTYLAEK"
     gene            complement(4499..5962)
                     /gene="msr(D)"
                     /locus_tag="VHC05_001157"
     CDS             complement(4499..5962)
                     /gene="msr(D)"
                     /locus_tag="VHC05_001157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000420317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F type ribosomal protection protein Msr(D)"
                     /protein_id="HEQ5402472.1"
                     /translation="MELILKAKDISVEFKGHDVLDINELEVYDYDRIGLVGANGAGKS
                     TLFKVLLGELIPPGCKMNHLGELAYIPQLDEVTLQEEKDFALVGKLGVEQLNIQTMSG
                     GEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
                     EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKRQAAEYEQFIAERARLERAAEEKRK
                     QARKIEQKAKGSSKKKSTEGGGRLAHQKSIGSKEKKMHNAAKSLENRIAALGKVEAPE
                     GIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIPLGAKVALTGGNGTG
                     KTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVL
                     ASMGFKQNDIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEIL
                     MKEYTGTIVFITHDKRLLENVADVVYEIRDKKIKLKH"
     gene            complement(6082..7299)
                     /gene="mef(A)"
                     /locus_tag="VHC05_001158"
     CDS             complement(6082..7299)
                     /gene="mef(A)"
                     /locus_tag="VHC05_001158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012102963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide efflux MFS transporter Mef(A)"
                     /protein_id="HEQ5402473.1"
                     /translation="MEKYNNWKLKFYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAM
                     VLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYMELPV
                     WMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAAL
                     LYSVWELNAIIAIDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQN
                     KGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLG
                     LFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQTAL
                     FQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIV
                     CPMINEIRKLDLK"
     gene            complement(7808..8019)
                     /locus_tag="VHC05_001159"
                     /pseudo
     CDS             complement(7808..8019)
                     /locus_tag="VHC05_001159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368983.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1643 domain-containing protein"
     gene            complement(8129..8545)
                     /locus_tag="VHC05_001160"
     CDS             complement(8129..8545)
                     /locus_tag="VHC05_001160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402474.1"
                     /translation="MRFKDFNLEVVNVERYSSDYSMTVNKNFVTFSKGIVQALEYPAH
                     VLVAFNKDTKVMGIQVCRAKTRGAFSFSKPVGEQKGIVQVGHKTLKETLLTIMSEWKS
                     DKRYRVEGIHIPEDKAFVFELKDFDELSDFRKNDNR"
     gene            complement(8560..9672)
                     /locus_tag="VHC05_001161"
     CDS             complement(8560..9672)
                     /locus_tag="VHC05_001161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEQ5402475.1"
                     /translation="MVRRNSKITRQQKKIRDAFVSERTVEIIPAKREFTDVKTKKLRV
                     AAYCRVSTFDESQSGSFELQKQTYTERINSNPDWIMAGIYADQGASGTSIKRREQFQQ
                     MLHDCRCGKIDLIIVKSVSRFARNQLDFISIYRELKALSPPVGIYIEDINLNTLDTNS
                     EFILGIMAIVAQGESEQKSASITWSVIERFKRGIPMIPTHNLLGYTKDQYGRVVIDET
                     EAKIVRLIYDSYIEGMTASEIASTLMTNHIPTVTGLERWTSLAVYNILRNEKYKGEII
                     MQKTYTVDCFSHKTRKNNGEKPKYRLKNGIPSIIPESRWDLVQELLKQPRRKSKSTSE
                     IFVPKLYIKKLKSGKLRDFVVLDPSWKSEDIHEVFK"
     gene            complement(9801..10457)
                     /locus_tag="VHC05_001162"
     CDS             complement(9801..10457)
                     /locus_tag="VHC05_001162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CpXC domain-containing protein"
                     /protein_id="HEQ5402476.1"
                     /translation="MMKRKIRMTTIFLTRTSCSNCGKQSTFERFDRVYAAKTPEIISA
                     ILDWDFFKFTCHNCNHKVLIDYPTVVVDEEQKTIIQYCADGNVDVLSMQICSLISEGV
                     NLSEYRIRVVSDIESFVEKVQIVSVGYDDRAIELMKYMNSPLEDGDIQFNYEHMVFTK
                     VGHENYQFMFINNQIAVASLDFSQEQYEYYLADVEDLETNTYYIDSRWAESFFRTSLA
                     "
     gene            complement(10562..12247)
                     /locus_tag="VHC05_001163"
     CDS             complement(10562..12247)
                     /locus_tag="VHC05_001163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003057995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEC/Rec2 family competence protein"
                     /protein_id="HEQ5402477.1"
                     /translation="MTFSWTKLVPLSKIQFAFLILVLFYQIHSPSWLTFLLSLSLICL
                     LVKRLSKKEFLGVFAILSFCALFLLYQKQQLVQKLEIQPVQITSVALVPDSIRINGDQ
                     LAVLGRHGKHSYQLFYRLKSQAEAQLFKKEHRWLVMHAKVTLEKAEEVRNFKGFNYQT
                     FLAYQGIYRIGKVEQIEQLEVISPESICDYLSSLRRRAIVHCQQHFPRPMSHYLTGLL
                     FGYLDTSFGEMTDYYSQLGIIHLFALSGMQVGFFLTCFRRVLLLLAVPLEWIKWIELP
                     FACFYAALTGYSISVIRSLVQSQLRHLGIKGLDNLACTFLLVFLWDAHFLMTVGGVLT
                     FSYAFLLTVVTVEELSGAKRQLVQVLTISLGILPFLLFYFSSFNPMSMVLTALLSYLF
                     DLFILPLLCLVFCLSPLVTVSICNHLFILLEKVIQFLGNTFNSSLVFGSPTSWHLLIL
                     VISFAIFYDYRQVRQRVITCGLVIALTLLSVKYPLTNEVTFIDIGQGDSILVREWTGK
                     NLLIDVGGRPFFSSKEHWRRGHHVANAQKTLIPYLKSRGIHTIDQLLVTHAEV"
     gene            complement(12228..12890)
                     /locus_tag="VHC05_001164"
     CDS             complement(12228..12890)
                     /locus_tag="VHC05_001164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEA family DNA-binding protein"
                     /protein_id="HEQ5402478.1"
                     /translation="MLDELLIKGKSFLRERYFLPYLISLLLGLFLILSFSFLFWGNRQ
                     SKAAVPALREISPVKQQVSEEKKEIQEDNSILVDLKGAVQKEGVYKLTASSRVRDVIE
                     LAGGLTSEADKHAINFAEKLTDEQVVYVPKQGEEISVLPRSLVSGKKETASKDQSKVH
                     INKASLEELQHIPGIGAKRAQDIIDMRDKLGGFKALEDLRQVSGIGEKTLEKLKDDIF
                     LD"
     gene            complement(13090..13830)
                     /locus_tag="VHC05_001165"
     CDS             complement(13090..13830)
                     /locus_tag="VHC05_001165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HEQ5402479.1"
                     /translation="MFYAYLRGLVVFLLWVVNGNAHYHHEEKMLDASENYILVAPHRT
                     FWDPVYMAFAARPKQFIFMAKKELFANRLFAWWIKMCGAFPIDRDKPSPDAIRYPVNM
                     LKKSNRSLLMFPSGSRHSQEVKGGVAVIAKLAKVKIMPAAYQGPMSVKRLLAGERVDM
                     TFGNPIDVSDIKRMNDEGIAEVANRIQAEFDRMDDELAPFQPGKARNPLTYLYRLPLG
                     LVLVVVLLLTMLFSYIASFVWNPDKHRH"
     gene            13870..14724
                     /locus_tag="VHC05_001166"
     CDS             13870..14724
                     /locus_tag="VHC05_001166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HEQ5402480.1"
                     /translation="MKADFSKVKITLQTFTSSLFYVKITGMIKAILKEGERIDQLFSS
                     DVGIIQNKDVFSYSIDSVLLSRFPKMPSKGLIVDLCSGNGAVGLFASTRTKAAIVEVE
                     LQERLADMGQRSIQLNQLEDQVTMICDDLKNLLNHVPRSGVDLMLCNPPYFKSHESSK
                     KNVSEHYLLARHEVTTNLEEICQVARHALKSNGRLAMVHRPDRFLEIIDSLRANGLAP
                     KRVQFVYPKLGKSANMLLIEAIKDGSIEGMTILPPLVVHKENGEYTDHIFEIYFGAAS
                     KGKPNHDH"
     gene            14714..14992
                     /locus_tag="VHC05_001167"
     CDS             14714..14992
                     /locus_tag="VHC05_001167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HEQ5402481.1"
                     /translation="MTTKKAYMYVLECVDKTLYTGYTTDLKKRLATHNAGKGAKYTRY
                     RLPVSLLYYEVFDSKEAAMSAEALFKKRKTRSQKLAYIATHQKEKKNH"
     gene            complement(15016..17017)
                     /locus_tag="VHC05_001168"
                     /pseudo
     CDS             complement(15016..17017)
                     /locus_tag="VHC05_001168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612436.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="potassium transporter Kup"
     gene            complement(17145..18764)
                     /locus_tag="VHC05_001169"
     CDS             complement(17145..18764)
                     /locus_tag="VHC05_001169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEQ5402482.1"
                     /translation="MKFTEFNLSQDIQSAVVTAGFEKASPIQEMTIPLALEGKDVIGQ
                     AQTGTGKTAAFGLPTLNKIRTNENIIQALVIAPTRELAVQSQEELFRFGREKGVKVRS
                     VYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALILDHVETLILDEADEMLNMGF
                     LEDIEAIISRVPADRQTLLFSATMPAPIKQIGVKFMKDPEHVQIKNKELTNVNVDQYY
                     VRVKEQEKFDTMTRLMDVNQPELSIVFGRTKRRVDEITRGLKLRGFRAEGIHGDLDQN
                     KRLRVIRDFKNDQIDILVATDVAARGLDISGVTHVYNYDITQDPESYVHRIGRTGRAG
                     KSGESITFVSPNEMGYLSMIENLTKKQMKPLRPATAEEAFQAKKKVALKKIERDFADE
                     TIRSNFDKFKGDAVQLAAEFTPEELALYILSLTVQDPDSLPEVEIAREKPLPFKYVGG
                     GHGNKNGKGGRGRDNRNRGDRRGGYRGDRNRDERDGDRRRQKRDKRDGHDGSGNRDFK
                     RKSKRNSKDFFNKEKKSSAKNTGFVIRHKGE"
     gene            complement(19071..20615)
                     /locus_tag="VHC05_001170"
     CDS             complement(19071..20615)
                     /locus_tag="VHC05_001170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 3"
                     /protein_id="HEQ5402483.1"
                     /translation="MSLTEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVK
                     GKKSGTFAKSDWMDIEKQRGISVTSSVMQFDYAGKRVNILDTPGHEDFSEDTYRTLMA
                     VDAAVMVVDSAKGIEAQTKKLFEVVKHRNIPVFTFINKLDRDGREPLELLEELEEVLG
                     IASYPMNWPIGMGRAFEGLYDLHNKRLELYKGDERFASIEDGDQLFANNPFYEQVKED
                     IELLQEAGNDFSEQAILDGDLTPVFFGSALTNFGVQTFLDTFLEFAPEPHGHKTTEGN
                     VVDPLAKDFSGFVFKIQANMDPKHRDRIAFVRIVSGEFERGMGVNLTRTGKGAKLSNV
                     TQFMAESRENVTNAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVS
                     PKNVMKQKSFHKGIEQLVQEGAIQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAE
                     VVMTPMGKKTVRWISEDDLDQRMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDV
                     TLEEKM"
     gene            complement(20863..21558)
                     /locus_tag="VHC05_001171"
     CDS             complement(20863..21558)
                     /locus_tag="VHC05_001171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02206 family membrane protein"
                     /protein_id="HEQ5402484.1"
                     /translation="MDFFAIDPIGLPHTSLIFYLSSLLIALLLVFLTFQAYRLKSYRY
                     FFLFLQLSQVIGLYTWYVLRGFPLDEALPLYHCRIAMLAIFFLPDRNKFKQLFMVLGI
                     GGTFLALLSPDLYPFRLWHVANVSFYLGHYALLVNGLIYLLRFYDASQLRLLSVVRYL
                     ATINFLLLLVSLATKGNYGFVMDIPVIHTRHLLLNFVIVTSGLTFMVKITEYFYLKFG
                     EAQQLALAFSKEK"
     gene            complement(21638..23029)
                     /locus_tag="VHC05_001172"
     CDS             complement(21638..23029)
                     /locus_tag="VHC05_001172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-
                     alanine ligase"
                     /protein_id="HEQ5402485.1"
                     /translation="MKLTLHEVAKIVDAQNNVSDLDDVPLHHIEFDSRKITKGDLFLP
                     LKGQRDGHEFIDLAFQNGAVATFSEKELSGKPHLLVEDCLKAFQKLAHYYIDKMRVDV
                     IAVTGSNGKTSTKDMIGAVLSTTYKTYKTQGNYNNEIGLPYTVLHMPDDTEKIVLEMG
                     QDHMGDIRLLSEIARPRIAVLTLVGEAHLEYFGSRNKIAQGKMQIVDGMNSDGILIAP
                     GDPIIDPYLPENQMVIRFGNQQEIDVTGIQEDKDSLTFTTNVLATPVSLPLPGKYNAT
                     NAMVAAYVGKLLAVTDEDIIAALQTVTLTGNRTEWKKAANGADILSDVYNANPTAMRL
                     ILETFANIAKNPGGKKIAVLADMKELGKDSVILHSQLIDSLTSGNIDQLVFYGDHIKE
                     LARLASQVYPAEQVHYFLKTEQEDQFEAMAQYVQNILNPFDQILLKGSHSMSLEKLVD
                     RLVTDKNCDSYQP"
     gene            complement(23227..24273)
                     /locus_tag="VHC05_001173"
     CDS             complement(23227..24273)
                     /locus_tag="VHC05_001173"
                     /EC_number="6.3.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
                     /protein_id="HEQ5402486.1"
                     /translation="MSKQTLVLLYGGRSAEREVSVLSAESVMRAVNYDKFLVKTYFIT
                     QMGQFIKTQQFSEKPSESERLMTNETIELTQKIKPSDIYEEGAVVFPVLHGPMGEDGS
                     IQGFLEVLRMPYIGTNVMSSSIAMDKITTKRVLESIGIPQVAYTVYIDGQDLEACLVE
                     TLARLTFPIFVKPANMGSSVGISKAQTKVELRKAIQLALTYDSRVLIEQGVIAREIEV
                     GLLGNDKVKSTLPGEVIKDVDFYDYQAKYVDNKITMAIPADVDQSIVTEMRSYAEVAF
                     KALGGCGLSRCDFFLTQDGQVYLNELNTMPGFTQWSMYPLLWENMGLAYPDLIEELVT
                     LAQEIFDQRESHLI"
     gene            complement(24374..24970)
                     /gene="recR"
                     /locus_tag="VHC05_001174"
     CDS             complement(24374..24970)
                     /gene="recR"
                     /locus_tag="VHC05_001174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination protein RecR"
                     /protein_id="HEQ5402487.1"
                     /translation="MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSNEDVNDFA
                     KNLLAAKRELTYCSICGNLTDDDPCHICTDTSRDQTTILVVEDAKDVSAMEKIQEYHG
                     YYHVLHGLISPMNGVGPDDINLKSLITRLMDGKVSEVIVATNATADGEATSMYISRVL
                     KPAGIKVTRLARGLAVGSDIEYADEVTLLRAIENRTEL"
     gene            complement(25017..25208)
                     /locus_tag="VHC05_001175"
     CDS             complement(25017..25208)
                     /locus_tag="VHC05_001175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEQ5402488.1"
                     /translation="MANPNGSVTIHAKIGTAETCITDNSDQTLVTYNLNVVAYNTNNE
                     DNIAVAVMYPHITNISAKM"
BASE COUNT         8214 a         5234 c         4399 g         7874 t
ORIGIN      
        1 aaactacaat tgcagaaaat ctttcgggaa atgatataaa atatctacga aaaaaatata
       61 atctcactca aaaagaatta gcagatgcac tcggtcttca aaaatttgga gatagaacca
      121 ttagacgttg ggaagcagaa gaaacgcatc cttcaaaact tgaacagtcc agtattcagt
      181 ctttttttaa ttctctaaag aatccgcctt ttattattag tgaaaatctt ccgttcaaaa
      241 tgatcgatct ttttgctgga ataggtggaa ctagattagg tttccaatta acaaatgaag
      301 tagaaactgt atttacaagt gaatgggata aatttgctca aaaaacatac attactaatt
      361 ttggagacac tccagaaggt gacatcactc agattgatga aaatactata ccagatcatg
      421 atatactcgt tgctggtttt ccttgtcaag ctttctccca agcaggtaaa cgtctaggat
      481 ttgaagatac tcgtggaact ttattttttg acgttgctag aataataaaa gctaaacgtc
      541 caaaagcttt tttacttgaa aatgtcaaaa acctaaagac acatgataaa ggtaagacat
      601 acaagataat catttcaact cttgagaatt taggatatag tacatcaact gtacttttta
      661 aggccagaga ttttggtgta ccacaaaata gagaaaggat ttatatagtt ggatttgata
      721 agacttgtgt aaataatttt agtgaattcc gtttccctga accgtttcat ttagaaacta
      781 aactaggaaa tattctacaa actgatgttg atgaaaagta tactatctcc gataaactct
      841 gggaaggaca ccaaagaagg aaagctgaac ataaaacaaa aggaaatgga ttcggctact
      901 cactatttaa tgctgatagt ccatatacaa atacactttc tgctcgatac tacaaagatg
      961 gaagtgaaat attaatagaa caaaaaggta aaaacccacg taaaattact ccacgagaag
     1021 ctgctagact ccaaggtttc cctgaagagt ttataattcc ggtttctgat acacaagcct
     1081 acaaacaatt tggaaattct gtctgtgtac caacaattca tgaaattgct aaacaaatac
     1141 tagccgtcct aaaaaaatag ttaatatata aagtctatca attgaattga tagacttttt
     1201 taattctagt tgcaaaatat aaatattctg atataatttt gttgagttat aactagacaa
     1261 aaaggagggg aacatgtttt ctcacggaag attaaaacaa cgaagacttg aaataaagtt
     1321 atcacagact gcaatcgcta atcaattaaa tgttcatcgt tccgcttacc ataattggga
     1381 aaacggaaga aacacaccta atcaaaaaaa cctcaccgct ctcgctgcta ttcttgatgt
     1441 accagtcact tattttgaat ctgaatacaa tatcgtaaat aactatcttc agttatctcc
     1501 cgataaccag ctaaaggcag aggagtatgt tgaggaactt cttctttccc aacaaacttc
     1561 aaacgtcatt cctctcttct cagtccaagt gctatcagat atccaactct cagctggtct
     1621 tggagaagga ttctttgacg agtttgaaac tgaaacaatc tactctgatg aggaacaata
     1681 cggttacgac attgctgctt ggattgaggg agattctatg gagcctgtat ataagagtgg
     1741 agaagtcgca ctaattcgtt caaacggttt cgactatgat ggtgcagtct atgcattatc
     1801 atggaatgac tcagtctata tcaaaaaact ctaccgtgat gaggatggat ttagaatggt
     1861 atccttgaat aaggactatc cagagaagtt catcccttac gaggatgaac ctagaattgt
     1921 tggtctagtt gtaggtcact ttatgcctgt cgagggagta tagtcatgaa gctaaaggat
     1981 attttagaac ttgggacgta tggtttcaat ccgaactgta aagttgaaat attctgtatg
     2041 gacaactttg aagagcggct agagaatgaa ggattcgatg aaattcttat tcctcaaaat
     2101 gatgatgcaa aaatctatcc ttacgctttt ttgatagagg attctatttt gattgctatg
     2161 accgaggtgg atgacgatat caatgaatgt taaagaaatg atttacatca aagacgaacg
     2221 tattatcttc acccctgaca aatttgaata cgacatcact gactacatcg gagaacttat
     2281 cgaagagcta gagaaactaa aaaggagata atcctatggg ctatatcgac tattctattg
     2341 aacctcaaag tgacatagcc ttcctcgata tgaagtcctt ctacgcttct gtagaatgtg
     2401 tggatagagg tttacatcca ctctacacat cactgtgcgt catgagccgt gcagacaact
     2461 cggcaggatt gattctcgct tcttctccaa tgtttaaaaa agtattcggt aaagcaaatg
     2521 taggtcgttc ctacgacttg ccatttgata taaacactcg aaaattcagc tatcagaatg
     2581 cgtggaaaca aggtcttgag gtaacaccga agtataaatc tttcatcgaa cactgggcaa
     2641 agcgtacact catcgttcct ccgcgaatgg acagatatat tgagaagaat ctagagattc
     2701 agcatatatt tcaagactat gctgctccag atgacattct cccctattca atcgatgaag
     2761 gctttattga ccttactagc tcactttctt actttatttc tgataagtca atgtcaagga
     2821 aagataagtt agataatgtt tcggctatga ttcagagaga tatttacagt aaaacaggta
     2881 ttatctcaac tgttggaatg agtaattcca atcctcttct agctaaacta gctctagata
     2941 atgaagctaa aaaaactgct acaatgagag cgaactggtc atacgaagat gtagaaacca
     3001 aggtatgggc cattccaaaa ctaacagact tttgggggat tggtagtaaa accgagattc
     3061 atttacaaaa acttggtatt cattcaatca aagaactagc caacttcaat cctgatattc
     3121 tcaaaaaaga attcggcaaa gttggtgttc agctatggtt tcacgcaaac ggtgttgatg
     3181 agagcaacgt ccatgaaccc tataaaccaa aatcacgagg attgggtaac tcacaagtac
     3241 ttcctagaga ttacagaacc caaagagaaa ttgaaatcgt attagctgaa atggctgacc
     3301 aggttgctaa ccgtcttcgc tcggcacata aaaaagctac tgtcgtttct attcatattg
     3361 gctattctag aactgagatg aaaaaatcaa ttaatgctca gaaaaaaatt gacccagcaa
     3421 atcttccaaa aacaatggtt ggtcatgtac ttgaattatt ccgaaagaaa tacacctctg
     3481 gtgcagtgag gcaaatcggt gtgtcttatg gtggctttgt agatgaaaac tttactctac
     3541 tgtcactttt tgatgatgta gaacaaattg aaaaagaaaa tagacttcag acagcaattg
     3601 atgttgtcag agaacagttt ggctttttag ctattcaaaa aggaaccgtc ctaaccgaag
     3661 gttccagaaa tattgaacgt agtaaactta tcggcggtca ttccgctggt ggattggagg
     3721 gattaaaatg attgatcgtt catacttgcc atttcagtca gcaagagagt accaggatac
     3781 taagatgcaa aaatggatgg gctttttcct atctgagcat acatcagcac tcactgacga
     3841 tgcaaacaaa gtaacgtata tgtcagattt gtcactggag aagaaattat tactcctcag
     3901 tcaggtgtat gctgggcaac tgaacacgcg cattcatgtt gttaaaaaaa caatcaagtt
     3961 tcctatactg gaacaatacc aagtctgacc aaagatttca ttttgataaa aactacaaca
     4021 ggtcacatta atttgaaatt gaaagacatt gttagtattg aacttgtaga ggaggtgctc
     4081 tatgaatcag cttgaatttc agcgtaatca cctgcaaatg gactattaca gcgagagcta
     4141 ccaagatttt gaacgtgact tctaccgcta ctccaacatg aatattccat tgaccttcct
     4201 gaccgatgat atcctcaaaa caatggcgac ttcacgtaag aattactttg tcctcaataa
     4261 ggaaaagtcc agagataacc gcgatcactt cttcatattt gaagtaagaa ccttagaaga
     4321 gaatccacta atctatcatt atacatataa gaaaactaca acatatttag cagaaaaata
     4381 ggagcagttc gatttactgt tcctattttt aatcttcata aaatctcaag tctttatact
     4441 ctttaacaat ggagtcgcca gccagaacag actatactga ccagcgacta cctaaaattt
     4501 aatgtttcag cttaattttc ttatctctaa tttcataaac tacatcagct acattttcga
     4561 gtaatcgttt atcgtgggtg ataaacacga tagttccggt gtactccttc attagtattt
     4621 ccaaagcctc taaacttggt atgtcaagga agttactggg ttcatccatt attaggatgt
     4681 tatatctacc catgagcatt ttagcaagca acaattttat aatttctcca ccgcttaaaa
     4741 cagataagct ttttccaata tcgttctgtt tgaaccccat agatgctagc acagaacgaa
     4801 tttctgatat attgtaatca caatccttct gcataaactc cataacattc tgattactgt
     4861 tgtacttgta accattctgt gcaaagtaac ctatttttgc cttaggtgaa atagaaattc
     4921 cttcttcatg gtttaagatc atttggatta aagttgtttt tccggttcca ttaccacccg
     4981 ttaatgccac ttttgctcct agcggaattt gaaaagatgc attttcaaac agtgccttat
     5041 ccccaaatac tttattaatt tccgcaccga ctatagggta tggattatgg agctccaatg
     5101 ctttactttg cctgaaacga attctgcgaa tgccttccgg agcttctact tttcctaatg
     5161 ccgcaatcct gttctctagg gatttagcgg cattatgcat ctttttttcc ttacttccta
     5221 ttgatttttg atgagctaaa cgccctccgc cttcagtact ttttttcttt gaagaacctt
     5281 ttgccttctg ttctatttta cgagcctgtt ttcgcttttc ctccgcagcc ctttccaatc
     5341 gagcacgttc cgcaataaat tgttcgtatt ctgcagcttg tctcttacgt tcttcctctt
     5401 tctgacgaag ataatcagaa tagtttcccc aatactcagt gattttgcca tctttcagtt
     5461 cccatatttt atctactatt tcatcaagaa aatagcggtc atggctaata actaacagtg
     5521 cacctgtaaa atattttagc tgtcctatta gaaaatcaat tccttcacgg tctaaatggc
     5581 tcgtaggttc atccgctaaa ataccatgaa cctgtgccga taaggcctgt gctattttaa
     5641 gccttgtttc ttcaccaccg ctcatggtct gtatatttaa ttgctcaaca cctagcttgc
     5701 ctacaagcgc aaaatctttt tcctcctgca gagttacttc gtccaactgg ggaatatagg
     5761 caagttcacc cagatgattc attttacatc ctgggggaat taattctcct aaaagtacct
     5821 tgaataaagt gctttttcct gcaccatttg ctcctactaa accaatacgg tcataatcat
     5881 atacttctaa ttcatttata tctaaaacat cgtgtccttt gaattccaca ctaatgtctt
     5941 ttgcttttaa tattaattcc ataacatttc ctcctgtcta taatcgcatg ctttcatttg
     6001 cttgtacgca ggaaaaaccc tgcgatttta gcaggaagaa ttacatgaaa ataagataca
     6061 taaatatccc tccaatattg tttattttaa atctaatttt ctaatctcat ttatcattgg
     6121 gcaaactatt gcaatgcaaa taattaaagt acctgatagt aaaaaccaat gatttacacc
     6181 gattctatca gcaaagagtg cagaaagaat taatccaatt ggcatagcaa gagacatgat
     6241 acttccagtt aaagaaaata cacgtcctaa atattcaggc ttaattttct cctgaaaaag
     6301 agctgtttgc acaccgctgt aaaacggaac agaaagcccc attattgcac agcagactac
     6361 aaaaatgaaa aatccacttt ggggaagtaa tcctgaaatg gttaagctta tccccatcat
     6421 aaaaatggat gccgttatta ataagattcg cttttggtaa ttcccaaata accctaataa
     6481 tagaccccct atcaacattc cagatgcaaa ggaaatttcc gtaatagaaa tatgcacagg
     6541 tgttccatta aagtaatcca tgctaattaa agggaatagt gcattaattg gcatataaac
     6601 aaacatatat aatgttccaa cgagtaataa agcaaataat cctttatttt gccgtagtac
     6661 agccattcct tcttgcattt ctcttatgaa atttgggtcc aaactttgca cgcgatcacc
     6721 cagcttagga atacgtacaa ttgctaccgt aatagatgca atcacagcac ccaatacatc
     6781 gatggcaata atagcattta gttcccaaac ggagtataag agtgctgcaa ccgccggact
     6841 aacaatatag cttatagact gcaaagactg actatagcct gcacatttcg taagctgttc
     6901 ttctggtact aaaagtggcg taaccgcatt gagagccggg gtgtgaaaag ctgttccaat
     6961 gctacggata aacaatacta tcataaccat ccagacaggt agctccatat agaatgcaac
     7021 aatagtaagc accgaaccag ctgctgcgat aattaaatca gcaccaatca ttatcttctt
     7081 cctatcatga cgatccacta gcacaccaat tgcaggtcca aagaccgcat agggtaaaaa
     7141 acctaatagt gaagccatag acaagaccat cgcggatcca gttttttctg taaggtaaaa
     7201 aataatcgcc atttgcaaga tggcactagt gattaatgat actgcttgcc ctgcccatat
     7261 tgtataaaac ttaagtttcc aattgttgta tttttccatt tatattatct cctgcatatt
     7321 attttgctta aatttctatt ttgaatagca ttataggcaa taaaaaaatg caggcctaaa
     7381 tccacaatgt ggcttttggt ctgcatacat acaatttgga aacattcata ttaaagacat
     7441 agttaaataa aggtatagtt aaataaaggt atagttaaat aaccaatatc ctcaccgtaa
     7501 ctaatgaatg ctcaatatcg tataaataag cacaacaaaa aagcctatca tcgggtatag
     7561 attctgcttt tcttattgcc agcttatctt aaacgcattg aggctgtcat agtttcggtt
     7621 cctcctaaat tcttatttgg attatcatat attttaacat aataagtcat tttaagcaac
     7681 ttataaatta aaaaaatcca ttaaaaaccg ccaaaggggg ttagccctta aattgcggtt
     7741 aatattctat atctcttcgt caatctcaat ccctgacttg aattcaacgg tgagcttatc
     7801 ttcatataat ttttttacta gcatttagaa ttcggttgat tgtacgatcg ctatagtcct
     7861 cattagctgc tgagggattc atacatatag ccacgagtgg attcgttcct aagcatccca
     7921 gtaggaatct acggtaggca ttatattttt caggaataca tagattaggt cttctcccaa
     7981 aggataggct agtctgactt ttgtaacttt atcgttcata gagttacctc ctacagtata
     8041 ttttaacatg aacccccttg caaggatatg aaaatggcag gaatacaata gttgtactcc
     8101 taccaataat ttttatcttc gttccttact atctattgtc gtttttacga aaatcagata
     8161 gttcatcaaa gtccttcaat tcaaaaacaa aagctttatc ttcaggaatg tgaatcccct
     8221 ctactctata acgcttatca gatttccatt cactcatgat tgttaagagt gtttctttta
     8281 aagttttatg acctacctga acaatacctt tttgctcccc aacaggtttt gaaaaagaaa
     8341 atgctcccct agtttttgca cgacaaactt gtatacccat tacctttgta tccttattaa
     8401 aggcaaccag tacatgtgct gggtattcta aagcttggac aattccttta ctaaatgtaa
     8461 caaagttctt gttcaccgtc atgctataat ctgatgagta acgttcaaca ttaacaactt
     8521 caagattaaa atctttaaaa cgcataattt acctctttct tatttaaaaa cttcgtgaat
     8581 gtcttccgat ttccaactag gatcaagtac aacaaaatcc ctcaacttac cagatttgag
     8641 tttcttgatg tagagtttag gtacaaatat ctcagaagta gatttcgatt ttcttctagg
     8701 ttgcttgagt aattcttgta ctaaatccca tcttgattct ggtatgatag agggaattcc
     8761 attttttaat cgatattttg gcttttcacc attatttttc cgtgttttat gactaaaaca
     8821 atcaacagta tatgtcttct gcatgatgat ttcgccttta tatttctcgt ttctgagaat
     8881 attataaaca gctaaacttg tccaacgctc caaaccagta actgttggta tatgattggt
     8941 cattaaagta gaggcaatct cacttgcagt cataccttcg atgtacgaat catatattag
     9001 gcgaacaatt tttgcttctg tctcatctat cactactcga ccatactggt ctttcgtata
     9061 cccaagaagg ttatgggtag gaatcattgg tatccctctt ttaaagcgtt caatgacaga
     9121 ccatgtaatt gacgcacttt tttgttcact ctcaccttga gctactatgg ccataatacc
     9181 aagaatgaat tcactattcg tatcaagtgt attcaaattt atatcttcga tatatattcc
     9241 aactggaggg gatagtgcct tcaactctcg gtaaatacta atgaaatcta gctgattacg
     9301 agcaaacctg ctaacactct taacgattat caagtcaatc ttcccacatc tacaatcatg
     9361 aagcatctgt tggaattgtt cacgtcgttt gattgatgtt cctgatgcac cttggtcagc
     9421 atagattcca gccattatcc aatcaggatt actattgatt ctttcagtat aggtttgttt
     9481 ttgaagttca aaactacctg actgagattc gtcaaaagta cttactcgac aatatgcagc
     9541 aacacgtaac ttcttagttt taacatcagt gaactctcgc tttgcaggaa taatttcaac
     9601 agttctctca gatacaaatg catctcgaat tttcttctgt tgacgggtaa ttttagaatt
     9661 ccgtcttacc attggtttta cctcctttct agaaatctac ataataatta tatatattaa
     9721 ctacgttttt ctaaattaga agataaaaaa tgacctaacc aaaaatcagg ccatttatac
     9781 ttataaatag attttgaatt ttatgccaaa ctggtacgaa agaatgattc cgcccatcta
     9841 gagtctatgt aatatgtgtt agtttctagg tcttcaacat cagcaaggta gtactcatat
     9901 tgttcttgag aaaagtcgag agatgctact gcaatctggt tattaataaa cataaattga
     9961 tagttttcat gtccaacctt ggtgaaaacc atatgttcat agttaaactg aatatcacca
    10021 tcctcaagag gactattcat atacttcata agctcaattg ctctatcatc ataccctact
    10081 gaaacaatct gtaccttctc aacgaaagac tctatatccg aaactactcg aattctatac
    10141 tcactgagat tgacaccctc tgaaatcaaa gagcatattt gcattgaaag tacatcaaca
    10201 ttaccatctg cacaatactg aataattgtt ttttgttctt catctactac gactgttggg
    10261 taatcaatta gcaccttgtg gttacagtta tggcaagtaa acttaaagaa atcccagtct
    10321 aaaatagcag aaataatctc aggagtcttc gccgcataaa ccctatcaaa tctttcaaat
    10381 gtactttgtt ttccacaatt gctgcagctt gttcttgtta aaaaaattgt tgtcattcta
    10441 attttcctct tcatcattat taagtaagca acttgctctc acttattata ttcgcaatgc
    10501 aaaataaatt ttagaatttt tttcaaaaaa aagttaaatt gtattgtatc aattttagaa
    10561 ctcacacttc tgcgtgagtt actaatagtt ggtcaattgt gtgaatacct ctacttttta
    10621 agtaaggaat taaggttttc tgagcattag ctacgtgatg tcctcgtcgc cagtgctctt
    10681 ttgaagaaaa gaaagggcgc ccacctacat ctattaagag atttttccct gtccactccc
    10741 tcaccaaaat actatctccc tggccaatgt cgataaaggt cacttcattg gtcaaaggat
    10801 atttgacaga caaaagcgtc aacgctataa ccaaaccgca agtgataact cgttgtcgca
    10861 cctgccgata atcataaaaa atagcgaagc taatcaccaa gataagcaag tgccaactgg
    10921 tcgggcttcc aaaaacaagg gaactattga aagtatttcc gagaaattga atgacttttt
    10981 ctaataaaat aaaaagatgg ttgcatattg agacagtcac caaaggggat agacaaaaaa
    11041 ccagacaaag aagaggtaaa ataaaaaggt caaagagata agacaagaga gctgttaaga
    11101 ccattgacat tgggttaaaa ctggaaaaat aaaagagcaa aaatggtaat attcctaggg
    11161 aaatggtcaa gacttgtacc aactgtcttt tagctcctga taattcttca acagtaacca
    11221 ctgttaacaa aaaagcatag ctaaacgtta atacgccacc aacagtcatt aagaaatggg
    11281 catcccataa aaagacaagt aaaaaagtac aagcgagatt gtctaatcct tttattccta
    11341 aatgacgcaa ctgcgactgc acgaggcttc gaataacaga aatactataa cctgtcaacg
    11401 cggcataaaa gcaagcaaaa ggaagctcta tccattttat ccattccaaa ggaactgcga
    11461 gtaatagcaa cacccttcta aaacaagtaa gaaagaagcc aacctgcatc cctgataaag
    11521 caaagagatg aatgataccc aactgactat aataatctgt catctcacca aacgacgtat
    11581 ctaaataacc aaaaaggagg cccgtcaggt agtgagacat aggtcttgga aaatgctgct
    11641 ggcaatgaac aatggctcgt cgtcttaaag aggacaaata gtcacatatt gactcgggtg
    11701 aaatcacttc aagctgttct atttgctcta ccttccctat cctgtaaatt ccttgataag
    11761 ccaaaaaagt ctgataatta aagcctttaa aatttcgaac ttcctcagct ttttccaatg
    11821 tcacttttgc gtgcatcact aaccaacggt gctctttctt gaacaattgg gcttctgctt
    11881 ggcttttcaa acggtaaaat aactgataag aatgtttccc atgacgtcca agaacagcta
    11941 attgatcacc attaatccga atactatcag gaactaatgc tacagaggtt atttgtactg
    12001 gctgaatttc cagtttttga accaactgct gtttctgata cagcaaaaac aaagcacaga
    12061 aactaaggat ggcaaagaca ccgagaaatt cttttttaga caaacgcttg acaagtaagc
    12121 aaatcaaact aaggctaagg agaaacgtta accagctagg gctatggatt tgataaaaga
    12181 gaaccaagat taaaaaagca aattgaatct ttgacagggg cactagctta gtccaagaaa
    12241 atgtcatctt ttaatttctc gagcgttttt tcgccaatcc ccgaaacctg acggagatct
    12301 tctaacgctt taaaaccacc taacttatct ctcatatcaa taatatcctg agctctttta
    12361 gcaccaatac ctgggatatg ttgtagttct tctaagctgg ccttattaat atgaaccttt
    12421 gactgatcct tgctggcagt ttctttttta ccagaaacta atgatcttgg tagcacagaa
    12481 atctcttctc cttgtttagg tacataaaca acttgctcat cagttagttt ttctgcaaaa
    12541 ttaatagcat gtttatcagc ttctgaagtt aggcctccag ctagttcaat gacatctcgc
    12601 acacgactgc tagcagttag cttataaact ccctcttttt gtacggcgcc ttttaaatcc
    12661 actaaaatac tgttatcttc ttgaatttcc tttttttctt cactaacctg ctgtttcaca
    12721 ggcgatattt ctctcaaagc aggaacggct gccttgctct gcctatttcc ccagaacaaa
    12781 aaactgaagc ttagtattag aaaaagtcct aataaaagac taattaggta tggcagaaaa
    12841 taccgctctc tcaaaaacga ttttccttta attaataatt cgtctaacat ttttttacct
    12901 catcttttta ttcgtaaatg atatccaaaa gtatagtagt attgtcattt tttgtgctta
    12961 aaagagttaa gggtatcatc gaatatcttt tttagaaatg aaaaaagtga ttaagcatta
    13021 gcggcttctt tcaatagaag actaatctca atcacttctt atttcaggca catgttagcc
    13081 ctcatgttct taatggcgat gtttatctgg attccaaaca aaactagcaa tataggaaaa
    13141 taacatggtt aataataata ccaccaccaa aaccaatcct aatggtaaac ggtagagata
    13201 agttaaaggg ttccttgctt tgcctggttg gaaaggtgcc aactcgtcat ccatccgatc
    13261 aaactctgcc tgaatacggt ttgccacctc agcaatccct tcatcattca tgcgtttaat
    13321 atctgagacg tcaatgggat tcccaaaagt catgtcaacc cgttctcccg ctagtaatct
    13381 cttgaccgac ataggcccct gataggctgc tggcataatc ttgaccttag ccaatttagc
    13441 aatcacagcg acccctcctt tgacctcttg cgaatgccta cttccacttg gaaacataag
    13501 aagagaacga ttgctctttt tgagcatatt aacagggtaa cgaatagcat ctggactcgg
    13561 tttgtcacga tcaataggaa aagcaccaca cattttaatc caccaagcaa agagacgatt
    13621 tgcaaacaac tcttttttag ccataaaaat aaactgctta ggacgtgctg caaatgccat
    13681 gtaaactgga tcccaaaagg ttcgatgggg tgctaccaga atataattct cagaagcatc
    13741 taacatcttt tcttcatgat ggtagtgggc attgccattg acaacccata ataaaaagac
    13801 tactaaaccg cgtaagtaag cgtaaaacac aggcttctcc tttaatagaa taatcttact
    13861 tattgtatca tgaaagctga cttttcgaaa gtcaaaatca ctcttcaaac attcacctca
    13921 agcctatttt atgttaaaat aacaggtatg ataaaagcaa tcttaaaaga aggcgaacgt
    13981 attgatcaac tcttttcaag tgatgttggc attattcaaa acaaggatgt ctttagttac
    14041 tctattgata gcgtcctctt atcccgcttc cccaagatgc cttccaaagg gttaattgtg
    14101 gatttgtgct caggaaatgg ggcggttggc ttatttgcta gcactagaac caaggcagcc
    14161 atcgttgagg tcgaattaca agaacggctt gctgatatgg gacaacgctc tatccagctc
    14221 aatcaactgg aagaccaagt aaccatgatt tgtgatgatt taaaaaacct cctaaaccat
    14281 gtgccacgtt caggagttga tttgatgctc tgcaatcccc cttactttaa aagtcacgaa
    14341 agttctaaga agaacgtctc tgaacattat ttactggctc gtcatgaagt gaccactaat
    14401 ttagaagaaa tttgtcaggt agcccgtcat gcccttaaat caaatggtcg tctggcaatg
    14461 gttcatcgac cagatcgatt cttggaaatt atagatagcc ttagagctaa tggtcttgcc
    14521 cctaaaaggg tacaatttgt ctatcctaaa ttaggtaaat cagctaatat gttacttatt
    14581 gaagcaatca aagacggttc tattgaaggg atgactattt tacctccttt agttgtccac
    14641 aaggaaaacg gagaatacac tgatcatatt tttgagattt attttggtgc tgcttccaaa
    14701 ggaaaaccta atcatgacca ctaaaaaagc ttatatgtat gtgttagaat gtgttgataa
    14761 aaccctctac actggttata caactgattt gaaaaagcgt ttagctacac ataacgcagg
    14821 aaagggggct aaatatactc gctaccggtt acctgtttct ttactttatt acgaagtgtt
    14881 tgatagcaaa gaggctgcga tgagcgctga agcactcttt aaaaaacgaa aaacaagaag
    14941 ccagaaattg gcctatattg ctactcatca aaaagaaaag aaaaatcatt gagacttatc
    15001 atctcaatga tttttttatg cttcactgtc ttccacaggc accaattctt tgattggtaa
    15061 cttcaagaca tctgatagaa tcaagggaac cacttcaagg gttacttctg aatattgaag
    15121 cccaaaccaa cgcattggac tagcggtaac atgtttaatg cttgccttag tctgcatgat
    15181 aaagcgttca aagttactca attgacgtgc attggagacc cgttcttcta ttaaaacaaa
    15241 gcgaaaatca ccaacatcac gaccaggtgt gatggtatat tcctgttctt gtttgggtaa
    15301 acggccactt tccatcaaat cctgaacaat cgtgcgcaaa tagcgtggca cagtctgtgg
    15361 cattctaaaa ccaagataaa ggttgactcg aaccatataa tccgttccca tcatatctac
    15421 cttgtactta gctgtataag gttcatcagt tacctggaca tttacaaacc aataaacttg
    15481 agcgcgtttt ggccgcttgt ctaaaatgga gtataaaata gaccggtcaa tcatatgatc
    15541 ctgcatacga ttggataggt agacaacatt tgtttggtag aggtcaaaac aaacgtcgtc
    15601 acgaagttgt ttaatctgct ccttgtaatc attcaaatta agagatttca catacttgaa
    15661 aacaatccgt gtgcccgcat gccagataaa catgacaaag acaattgcaa gtgccaagat
    15721 aacaaccgca tagccaccgt gcataaattt gatagctgaa gccaagaaga aaatgaattc
    15781 tacaagggca aagaaagcca tcgctaaatg agccaagatg ggtctcgttc ctttcttgat
    15841 taagtaatac tttaagagga ttgttgtcat caacatggtg atggtaatag caagaccata
    15901 agctgcctcc atgtgggctg atgttctaaa agccaaaaca gtacaagagg tcactgcaaa
    15961 taaaatccag ttaatgacag gaatatacaa ttgccccaaa tttgcccctg ggtaagtcac
    16021 acgaaacaaa gggaaaattt tcaaacgcat ggcctctgaa accaaggtaa aggagcctga
    16081 aataagagcc tgtgaggcaa taatagctgc caaggttgcc aaactaacaa ggtaaactct
    16141 taattgtgat ggcacactag caaagaaagg gtttagttca atacctgagt gtttattcgc
    16201 taaaatccac gcagcctggc cacagtaaga ccacacaata cacatcttaa caaagggcca
    16261 gctcacataa atatttcctc gaccaacatg tcctaaatcc gaataaaggg cttcagctcc
    16321 tgttgtcgca agaaaaatgg accccaagat aaaaatccca cgatggtttt caggactaaa
    16381 cagcaaatgc agagcatagt aaggattgat agccttgaaa atttccagat gccccaacgt
    16441 attaaaaaaa ccactaacac ctagaaaact aaaccagata aacataactg gtccaaaaat
    16501 tttaccaata aaacctgttc caaaccgctg aataccaaac aagactatta aaatcactag
    16561 agttgtgata atgatattgg tttgattttg gtagatgtga ctcagaccag gaacggcttt
    16621 caagccctca atagctgaag taactgttac cgcaggtgta agaagcccca tcagacaaaa
    16681 gtgttgcacc tccaatcatc gccggaataa tgagccacgg tgacatttta cgtaccaagg
    16741 tgaataaaga aaaaatccca ccttcatggt ggttatccgc ttttagagca atcaaaacgt
    16801 acttgattgt tgtgattaag gtcagtgtcc aaataattaa agagattgat cctaaaataa
    16861 aggattcaga aacctgatta acccctcctt gattttcaac tagagactgc atcgtataaa
    16921 gggggcttgt tccaatatct ccataaacaa tacctaaagc aataataaaa cctgcttttg
    16981 aagctttgtc aaaggcagta agatggctat cagatatctt atactcctcc taatttttta
    17041 aaaattatca caaaaataac tgaaaccatt ataacagatt ccattataaa agcaactttt
    17101 tcagaaaatt aaaaagagct gactctcatc aactctcttt aagcttattc acctttgtga
    17161 cgaatcacaa aaccagtatt tttagcactt gattttttct ctttattgaa aaagtcttta
    17221 ctattacgtt ttgatttacg tttgaaatcg cggttgccac tgccatcgtg accatcacgc
    17281 ttatcacgtt tttgacgacg acggtcacca tcacgctcat ctctgttacg gtcaccacga
    17341 tagccgccac ggcgatcacc acggttacgg ttgtcacgtc cacgaccacc tttgccattt
    17401 ttattgccgt gaccaccacc cacatatttg aatggtaatg gtttttcacg tgcaatttca
    17461 acttccggta agctatctgg atcttgaacc gttaagctca aaatatataa agctaattct
    17521 tcaggagtga attcggcagc caattggaca gcatcgcctt tgaatttatc aaagtttgaa
    17581 cgaatagtct catccgcaaa gtcgcgttca attttcttga gggctacttt tttcttggct
    17641 tgaaaggcct cttcagcagt tgctggacga agaggtttca tctgtttttt cgttaagttc
    17701 tcaatcattg agaggtagcc catctcattt ggtgagacaa aagtgataga ctcaccagat
    17761 ttaccggcac gacctgtacg accaatacgg tgaacataac tttctggatc ttgggtaata
    17821 tcgtagttat aaacgtgggt aactcctgaa atatcaaggc cacgcgctgc tacatcagtg
    17881 gcaacaagaa tatcaatttg gtcgtttttg aaatcacgga taacacgtaa gcgtttattt
    17941 tggtcaagat caccatggat tccttcggca cggaaaccac gaagtttcaa gccacgtgta
    18001 atttcatcaa ctcggcgctt agtccgccca aaaacgatgg ataattctgg ctggttaaca
    18061 tccatcagac gggtcatagt atcaaatttt tcttgttctt tcacacgaac atagtattga
    18121 tcaacattga cgtttgttaa ttctttgttc ttaatttgaa catgttcagg gtctttcatg
    18181 aatttaaccc cgatttgttt aataggtgcc ggcatcgttg cggagaagag caaggtttga
    18241 cggtctgctg ggacacgact aataatagct tcaatgtctt ccaagaatcc catgttaagc
    18301 atttcatctg cttcatcaag gattaaggtt tccacatgat ctaaaataag agccttgcgc
    18361 ttaatcaaat ctaacaagcg acccggtgtt cccacgacaa tgtgggcacc tgatttaagg
    18421 gctttgattt gtttttcaat acttgatcca ccgtaaacag agcgaacctt aacccctttt
    18481 tcacgtccaa aacggaacaa ttcttcctga ctttgtacag ccaattcacg cgttggtgca
    18541 atgaccaatg cttggatgat attttcgtta gtacgaatct tattcaaggt tggtagacca
    18601 aacgctgctg ttttaccagt tcctgtttgt gcttgaccaa taacatcctt cccttctagt
    18661 gcgagaggaa tcgtcatttc ctggatagga gatgctttct caaaaccagc ggtaacaaca
    18721 gctgattgga tgtcttgtga taagttaaat tctgtaaatt tcaattgttt ctcttttcta
    18781 aaaaggcagt gcgaagctgc cttataaacc ttttaatttt cgtcgtttga ttaacaacct
    18841 aactagtgta acacaattag aatcaaaaag ataggaaata aggctaatat aagcaataac
    18901 acgctttcac gattatccgc taaatcataa atatgcttac agttgtgaag atatcgtttt
    18961 ttgatagaat cttaaatctg caaaagagat aactagccac tcatttcttt taaaaagttg
    19021 ctcagtaaat tgatctccaa aacgttagac tgttgaaaat catgtttcga ttacattttc
    19081 tcttctaaag tgacatctgg gtatttgtct gcaaaccagc gaagggcaaa atcattttca
    19141 aataggaaaa ctggttggtc aaaacgatcc ttagctaaaa tgtttcggct tgaagacatg
    19201 cgttgatcca aatcatcttc tgaaatccag cgaacagtct ttttacccat tggtgtcatc
    19261 acaacttcag cgttgtattc accttccata cgatgtttaa agacttcaaa ctgcagttga
    19321 cccacagcac ccagcatgta ttcgcctgtc tgataattct tataaagctg aattgctcct
    19381 tcttgtacta attgttcaat acctttgtgg aaggatttct gcttcataac atttttcgga
    19441 gaaaccttca tgaagatttc tggggtaaaa gttggtaagg gttcaaattc aaatttattt
    19501 ttcccaactg ttaaggtatc cccaacttga taagttcctg tatcataaac cccgataata
    19561 tccccagcaa cagcattcgt cacattttcc cgtgattctg ccataaattg agtaacattg
    19621 gagagcttag cgcctttgcc agtgcgtgtc aaattaactc ccataccgcg ctcaaattca
    19681 ccagaaacaa tacgcacaaa agcaatacgg tcacggtgtt tagggtccat gttagcttga
    19741 attttaaaga caaaacctga aaaatcttta gctaaggggt caacaacatt accttctgta
    19801 gtcttgtgac catgaggttc tggggcaaac tccaagaaag tatcaagaaa agtctgaact
    19861 ccaaagttcg taagggcaga gccaaaaaag actggagtta ggtcaccatc aagaatagct
    19921 tgttctgaaa agtcattacc tgcttcttga agaagttcaa tatcttcttt gacttgttca
    19981 taaaagggat tattggcaaa cagctgatca ccgtcttcaa tacttgcaaa acgctcgtct
    20041 cccttataga gttctaaacg tttattatgt aaatcatata agccctcaaa ggcgcgtccc
    20101 ataccaatcg gccagttcat cggataagaa gcaatcccta aaacttcttc taattcttcc
    20161 aagagttcta aaggctcacg cccatcacgg tctaacttgt taataaaggt gaagacagga
    20221 atattacgat gtttgacaac ttcaaaaagt tttttcgttt gcgcctcaat acctttagcc
    20281 gaatctacaa ccatgacagc cgcatccaca gccattaagg tacggtatgt atcttccgag
    20341 aaatcctcat gtccaggtgt atccaaaata ttaacacgtt tacccgcgta atcaaattgc
    20401 ataacagatg aagtaacaga gataccacgt tgcttttcaa tatccatcca gtcggacttt
    20461 gcaaacgtac ctgatttttt cccttttact gtccctgctt ctctaatttc accaccaaaa
    20521 tataatagtt gctcagtaat agtcgtctta ccagcatccg ggtgagaaat gatggcaaaa
    20581 gtacggcgtt ttttaatttc ttctgtaagt gacattcttt tttccttgta tagtaaaatg
    20641 gcagagcttt tctctgagtt attttcgtta ggtattactt gtttatcaaa agagttgggc
    20701 tacattgggt ttctccatat acgattagcc tctaaagttc ttcaaaactg gtattataac
    20761 ttatcttggg ctatcaatga gtgtcttttt taaaaaaatc gagcctggaa atcatcccag
    20821 actcttctta ttatagctga ttttaagtgc tttttcaacg acctactttt ctttagagaa
    20881 agcaagtgcc agctgttgag cttcaccaaa tttaaggtaa aaatattcgg ttattttaac
    20941 cataaaagtc aagccacttg taacgatcac aaaattaagt agcaaatgac gcgtatgaat
    21001 cactggaata tccatcacaa aaccataatt tcctttcgtg gctaaactga ccaacagaag
    21061 aagaaagtta atagttgcta aatagcgtac tactgatagc agtcttaact gactggcatc
    21121 gtaaaaacgc aagaggtaaa tcaaaccatt cactaacaaa gcataatgac caagataaaa
    21181 cgagacattt gctacatgcc ataatctaaa cggataaaga tctggcgata aaagtgcaag
    21241 gaatgttcca cctatcccca aaaccataaa taattgctta aacttgttac gatcaggtag
    21301 aaaaaagata gctaacatag cgatgcgaca gtgatacaac ggcaaagctt catctaaagg
    21361 aaaccccctt aacacgtacc atgtgtacaa gccaatcacc tgagataact gtaaaaacaa
    21421 gaaaaaataa cgataagatt ttaacctata tgcttgaaaa gtcaaaaaaa caagcaaaag
    21481 cgctatcaag agtgacgaca agtaaaagat aagtgaggta tgaggcagtc cgatggggtc
    21541 aattgcaaaa aaatccataa tcgtcccttt ctatattttt tcattatacc ttaatcttca
    21601 tgagagaaca agcctttctc tgaaagtttt ataaaaatca aggctgatag ctgtcacaat
    21661 tcttgtcagt cactaatcga tctactaact tttctagcga catcgagtgg ctgcctttta
    21721 aaagaatttg atcaaaggga ttaagaatgt tttgaacata ttgtgccatg gcttcaaact
    21781 ggtcttcttg ttcagttttt aaaaaataat gtacttgctc agcaggataa acctgacttg
    21841 ccaaccgtgc taattcttta atatgatccc cataaaaaac aagctgatca atattacctg
    21901 atgttaagct gtcaattaac tgagaatgaa gtatcactga atcctttcca agttctttca
    21961 tatctgctag cactgcaatc ttttttcctc cggggttctt tgctatgtta gcaaatgttt
    22021 ctaaaatcag acgcatggct gttgggttgg cattgtagac atctgataaa atatcagcac
    22081 cattggctgc tttcttccac tccgtacgat tacctgtcaa cgtcacagtc tgtaaagcag
    22141 ctataatatc ctcgtctgtt actgccaata gttttcctac ataggctgct accatagcat
    22201 tggtcgcgtt gtattttcct ggtagaggta gggacacagg tgttgctaac acatttgttg
    22261 taaacgttaa gctatctttg tcttcttgaa taccagtaac gtcaatttcc tgctgatttc
    22321 caaaacggat aaccatctga ttttctggaa gatatgggtc aataatcgga tctcccggag
    22381 caattaaaat cccatctgaa ttcatgccgt caacaatctg cattttgcct tgggctattt
    22441 tgtttcggct tccaaaatat tctaaatgag cttcgccgac taaggttaaa actgcaatac
    22501 gaggccttgc aatttcagac agaagacgaa tatctcccat gtgatcttgt cccatttcaa
    22561 gaacaatttt ttccgtatcg tcaggcatgt ggagaacggt gtaaggcaaa ccaatctcat
    22621 tattgtaatt tccttgcgtt ttgtaagttt tgtaagtggt tgataggaca gctcctatca
    22681 tatctttggt ggaagtttta ccatttgagc ctgtcacagc aataacatcc acgcgcatct
    22741 tatcaatata ataatgggct agcttttgaa aagcttttag gcagtcttca acaagaaggt
    22801 gaggtttccc cgacaattct ttttctgaaa aagtagcgac agctccattt tgaaaggcta
    22861 aatcaataaa ctcatgacca tccctttgac cttttaaggg taaaaagagg tctccttttg
    22921 taatctttcg gctatcaaat tcaatgtgat gcagaggaac gtcgtctaag tcagacacat
    22981 tattttgggc gtcaactatt ttagccactt cgtgtaaggt taatttcatt ttgttttctt
    23041 tctaagaaca ctagtattta cgatgtccta tctattatag cacaaaacat tagaaaaatt
    23101 tctaaaatgt caaactccct taatggctct actattcttc ctaaaagagc aacaaaaaag
    23161 gacgaacgtc acatcttgac gatgtttgcc gttccatcca agtcaatgtt tattcatctc
    23221 ataggtttaa atcagatggc tctcacgctg atcaaatatt tcttgtgcca gtgtcaccag
    23281 ctcttcaatc aaatctggat aagccaatcc catattttcc cataagagtg gatacataga
    23341 ccattgggta aagcctggca tggtgtttaa ttcgttaagg taaacctgtc cgtcttgggt
    23401 caagaaaaag tcacaacggg acaacccaca accacctaag gctttaaagg ctacttcagc
    23461 ataagaacgc atttctgtca caatactctg gtctacatct gctggaatgg ccatcgtaat
    23521 cttattgtca acatattttg cttggtagtc gtaaaaatca acgtccttga ttacttctcc
    23581 tggtagagtt gatttaacct tatcatttcc aaggagacca acttcaattt ctctggcaat
    23641 cacgccttgt tcaatcaaga cacgactgtc ataggtcagg gctaactgaa tcgcttttct
    23701 taattctact tttgtttggg ctttggaaat ccccacagaa gaacccatat tagctggttt
    23761 tacgaagata ggaaaagtaa gtcttgctaa agtttcaact aaacaagcct ccaaatcttg
    23821 tccgtcaata taaacagtat aggcaacttg tggaattcca attgattcta agacacgttt
    23881 agtagtaatt ttatccatag ctatgctaga agacatgaca ttagtcccta tatatggcat
    23941 tctaagcact tctaagaaac cttggataga gccatcttct cccataggtc catgtaatac
    24001 aggaaataca actgcacctt cttcatagat atcacttggt tttatttttt gagttagctc
    24061 tatcgtctca tttgtcatca agcgttctga ttccgatggc ttttctgaaa attgctgagt
    24121 tttgataaat tggcccatct gagtaataaa ataagttttt actaagaact tatcatagtt
    24181 gactgctcgc atcacactct ctgctgaaag cactgagact tcacgttctg ctgagcggcc
    24241 tccgtataat agaactaacg tttgtttgga catagctaac ctttcttatc tgaattgaat
    24301 gtttttttat tataacaaaa agatgtagcc ttttcaaaac ctctctttgc gagtaaaggc
    24361 accaacatga tcattaaagt tcagtacgat tctcaatagc tctcaataat gttacttcat
    24421 cagcatactc aatatctgaa cctactgcga gacctcttgc caaacgagtt accttaatcc
    24481 cggctggttt caagacacgt gaaatataca tggacgttgc ttccccatct gctgtggcat
    24541 tggtagctac gataacttcg ctcaccttac catccattag acgggtaatt aaacttttaa
    24601 ggttgatgtc atctggcccc acaccattca taggcgaaat caagccgtga agcacatgat
    24661 aatagccatg atactcttgg attttttcca tggcagaaac atctttagca tcttctacta
    24721 ccagaatggt cgtctgatca cgactcgtgt ctgtgcaaat gtgacaagga tcgtcatcgg
    24781 taaggtttcc acaaatcgaa caataggtca gttctctttt agctgctaat aagtttttag
    24841 caaaatcatt gacatcttca tttgacattc caatagtata aaaggctaat ctcgtcgccg
    24901 tcttgatacc aattcctgga agtttagagt aactgtcaat taactttgca atgggtgttg
    24961 gataaagcac taagttctcc tttattgttt tccatatatc gccacataaa gcgccctcac
    25021 atctttgccg atatattcgt aatatgtgga tacataacag caaccgcaat attatcttcg
    25081 ttatttgtat tataagctac tacatttaag ttgtaagtta ctaaggtctg atctgaattg
    25141 tctgtgatac aagtctcagc agttccaatt ttagcgtgaa tcgtgacaga accgtttgga
    25201 ttagccaagt aaaaactttt ttactcgact tgttaccttg gccttgagat atttggcttt
    25261 tgttttttga ttcatgttac ttttttagaa accgcaaacc atccttatga tataagttta
    25321 taggaattgt ttcattccat gcagaaatga tgtttactca attgactatg ctatttttct
    25381 caacaatagt gcataaagca aactcatggt tatctttaag ctttcatgct acactttctt
    25441 cactaaaagt atattaccaa aagcagtatt aagaaatctc taagcacaaa ccataagaca
    25501 gtttgtacgc ctgatgaatc tgttgctgca tcactgtcca ctttttaccc taacaaggct
    25561 atttttgaaa gacaactaat gatctacatt attttgggaa ctactcccat agcaaattct
    25621 ttttacggat tttttgggaa tactcatttt ttagggaata aactaaccat tatttagcta
    25681 aattttttaa acttcgcttc ttattttacc ataaattata a
//
LOCUS       DAUDWO010000028        24578 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.028, whole genome shotgun sequence.
ACCESSION   DAUDWO010000028 DAUDWO010000000
VERSION     DAUDWO010000028.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 24578)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24578)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24578
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.028"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..92
                     /locus_tag="VHC05_001176"
     CDS             <1..92
                     /locus_tag="VHC05_001176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="type II-A CRISPR-associated protein Csn2"
                     /protein_id="HEQ5402489.1"
                     /translation="VLFLEPRELYDFPQYILDEDYFLITKNMV"
     gene            362..808
                     /locus_tag="VHC05_001177"
                     /pseudo
     CDS             362..808
                     /locus_tag="VHC05_001177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018370026.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-diphosphate kinase"
     gene            878..2710
                     /gene="lepA"
                     /locus_tag="VHC05_001178"
     CDS             878..2710
                     /gene="lepA"
                     /locus_tag="VHC05_001178"
                     /EC_number="3.6.5.n1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017645216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor 4"
                     /protein_id="HEQ5402490.1"
                     /translation="MNSQDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLA
                     ACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRHEVEDVI
                     GLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVDAPLQALIFDSVYDAYRGVILQ
                     VRIVNGIVKPGDKIQMMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYVAASIKTVAD
                     TRVGDTVTLANNPAKEALHGYKQMNPMVFAGIYPIESNKYNDLREALEKLQLNDASLQ
                     FEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVHTTDEDMIE
                     VSNPSEFPDPTRVAFIEEPYVKAQIMVPQEFVGAVMELSQRKRGDFVTMDYIDDNRVN
                     VIYQIPLAEIVFDFFDKLKSSTRGYASFDYDMSEYRRSQLVKMDILLNGDKVDALSFI
                     VHKEFAYERGKIIVEKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGG
                     DVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDTKK"
     gene            2999..4000
                     /locus_tag="VHC05_001179"
     CDS             2999..4000
                     /locus_tag="VHC05_001179"
                     /inference="COORDINATES: protein motif:HMM:NF013550.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_164232585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEQ5402491.1"
                     /translation="MLTFGGASAVKADAVGRQQVQDELQNQRKALPRLKEFYKDTPNS
                     GVENTPIYKYLTEMEGKLNRYLETLDKGLHQLQGDKGEPGAQGPAGPRGETGPAGERG
                     EKGAQGPRGEQGPQGLPGKDGEAGAQGPAGPMGPAGERGEKGEPGTQGAKGDRGETGP
                     AGPRGDKGEKGEQGPAGKDGERGPIGPAGKDGQNGKDGLPGKDGKDGQNGKDGLPGKD
                     GKDGQDGKDGLPGKPAPQTPEVPQKPDTAPHTPKTPQIPGQSKDVTPAPQNPSNRGLN
                     KLQTQGGNQLAKTPAAHDTHRQLPATGETTNPFFTAAAVAIMTTAGVVAVAKRQENN"
     gene            4186..4623
                     /gene="msrB"
                     /locus_tag="VHC05_001180"
     CDS             4186..4623
                     /gene="msrB"
                     /locus_tag="VHC05_001180"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HEQ5402492.1"
                     /translation="METSDELKQRIGDLSYEVTQHAATESPFTGKYDDFFEKGIYVDI
                     VSGEVLFSSLDKFNSGCGWPAFSKPIENRMVTNHDDSSYGMRRVEVKSREAGSHLGHV
                     FSDGPKEAGGLRYCINSAALKFIPYDQMEKGGYAQWLTLFDET"
     gene            4753..5772
                     /locus_tag="VHC05_001181"
     CDS             4753..5772
                     /locus_tag="VHC05_001181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015017089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YeiH family putative sulfate export transporter"
                     /protein_id="HEQ5402493.1"
                     /translation="MSTNLRKLPGLLLCLLLALPAWYLGRLFPIIGAPVFAILLGMLL
                     ALFYEHRDKAKEGISFTSKYILQTAVVLLGFGLNLTQVMAVGMQSLPIIISTIATALL
                     VAYGSQKWLGLDVNTATLVGVGSSICGGSAIAATAPVIKAKDDEVAKAISVIFLFNML
                     AALLFPSLGQLLGLSNEGFAIFAGTAVNDTSSVTATATAWDALHHSNTLDGATIVKLT
                     RTLAILPITLGLSLYRAKKEHDIVTEEGFSLRKSFPRFILFFLLASLITTLMTSFGVS
                     ADVFHSLKTLSKFFIVMAMVAIGLNTNLVKLIKTGGQAILLGAICWVAITLVSLAMQL
                     SLGIW"
     gene            5979..6404
                     /locus_tag="VHC05_001182"
     CDS             5979..6404
                     /locus_tag="VHC05_001182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000823118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEQ5402494.1"
                     /translation="MKRKFLIGSHGRLASGLQSSIDILAGMGQALETIDAYVDDSDYT
                     SQIDDFIAGVAADEQGLIFTDLLGGSVNQKMVTAVMNSGKDNIFLITNSNLATLLSLV
                     FLKPDEALTKDEIVTVINESQVQLVDLVPETNSEDDFFD"
     gene            6431..6922
                     /locus_tag="VHC05_001183"
     CDS             6431..6922
                     /locus_tag="VHC05_001183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system
                     mannose/fructose/N-acetylgalactosamine-transporter subunit
                     IIB"
                     /protein_id="HEQ5402495.1"
                     /translation="MITQIRVDDRLIHGQVAVVWTKELNAPLLVVANDEAAKNEITQM
                     TLKMAVPNGMKLLIRSVEDSIKLFNDPRATDKRIFVIVNSVKDACAIAKEVPDLEAVN
                     VANVGRFDKSDPASKVKVTPSLLLNPEEMAAAKELVSLPELDVFNQVLPSNTKVHLSQ
                     LVN"
     gene            6939..7748
                     /locus_tag="VHC05_001184"
     CDS             6939..7748
                     /locus_tag="VHC05_001184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017644846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEQ5402496.1"
                     /translation="MLVPATMAALAVLICFGGNYLTGQSMMERPLVVGLVTGLLLGDM
                     KVGILMGASLEALFLGNVNIGGVIAAEPVTATAMATTFTIISHIDQKAAMTLAVPIGM
                     LAAFVVMFLKNVFMNIFAPMVDKAAAANHQGKLVMLHYGTWIIYYLIIASISFIGILV
                     GSGPVNAFVEHIPQNLMNGLSAAGGLLPAVGFAMLMKLLWTNKLAVFYLLGFVLTAYL
                     KLPAVAVAALGAVICVISSQRDLELDAITRGAINKQTTFDSKESEEEDFFA"
     gene            7745..8572
                     /locus_tag="VHC05_001185"
     CDS             7745..8572
                     /locus_tag="VHC05_001185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEQ5402497.1"
                     /translation="MTSQDNLTKEDRKMLRSVFWRSWTMNASRTGATQYHAVGVIYTL
                     LPVINRFYKTDKDKAEALVRHTTWFNATMHINNFIMGLVASMEKKNSEDPDFDASAIT
                     AVKASLMGPISGVGDSFFWGILRVIAAGIGISLASAGSAMGAVVFLLLYNIPAFIIHY
                     YSLYGGYSVGAGFIKKLYESGGIKIVTKTSSMLGLMMVGSMTASNVKFKTILTVAAKG
                     AKEAASIQDYLDQLFIGIVPLMVTLAAFWLLRKKVNINWIMFGIMFLGIILGLLGIC"
     gene            8708..10357
                     /locus_tag="VHC05_001186"
     CDS             8708..10357
                     /locus_tag="VHC05_001186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEQ5402498.1"
                     /translation="MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAP
                     QQLGLYRDINATATRYHRLISKQEALLDELGKNSLLPFLNKNLSTADLSKHYFHLRRS
                     SQTSPELLLFSPNQGLLFASNPHLGNVFSKSVYIQEVLRAAHPPKTLFKVAMDSEDGH
                     YLMIIKPMIDQNQLKGYAFLVMSGKDFLHPTKTLTSELVIADKLDNTVTFSNREFIAS
                     SLDKINSQYLHHYFVFQDNRAFITRKVALQGGLWLYMYRPLIPMVSVMLFSLISSAVI
                     FVILQRKSSGLANRIAAKNSRAINQMVRDMSAISRQEKRRIDLESQDEFQYLSDQINQ
                     MVERLQQLHDKTLDLETQKLLFEKRMLEAQFNPHFLYNTLETILITSHYDSALTEKIV
                     IQLTKLLRYSLTDSSKPVLLKDDLSVIESYLVINQVRFEELQYSINLSPDLDSLAVPK
                     LFLLPLIENAIKYGLKERHDVKINIACYYQDDHIIFSVRDNGSGIDAHHQKVIREQLE
                     AGESHHGLINSYRRLKYHFSEVSLVFDQGDKQFNVSYHVKE"
     gene            10361..11149
                     /locus_tag="VHC05_001187"
     CDS             10361..11149
                     /locus_tag="VHC05_001187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5402499.1"
                     /translation="MYKLVIIEDEHIIRKWLRYAIDYKALDILVIGEAKDGKEGAVLI
                     KESQPDIVLTDINMPIMTAFDMFEATKDQTYAKIILSGYADFPNARSAIHYGVLEFLT
                     KPIEKAALWECLQTIIAKIEKQKGSNQKTDACVYIPLPQMTDQIPEVVKDILEWVHAH
                     FQDKISTSRLAHDLGYSESYIYQNIKKHLQMPLSDYINQYRINQAIQLMQQEPDLMVY
                     EIAQAVGIYDYRYFDRVFKKYLGQTVKAFKEEHFMKDTDRSKPC"
     gene            11143..12189
                     /locus_tag="VHC05_001188"
     CDS             11143..12189
                     /locus_tag="VHC05_001188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEQ5402500.1"
                     /translation="MLKLKRKWLLSFLLVIIILAIVNVAMYIFSSSKKDSAKELVILT
                     PNSQTILTGTIPAFEEKYGVKVRLIQGGTGQLIDQLGRKDKPLNADIFFGGNYTQFES
                     HKDLFESYVSPQVSTVISDYQLPSHRATPYTINGSVLIVNNELARGLHITSYEDLLQP
                     ALKGKIAFADPNSSSSAFSQLTNILLAKGGYTSSEAWEYVKRLLLSMNSIRATSSSDV
                     YESVAEGKMIVGLTYEDPCINLQKSGANVSVVYPDEGTVFVPSSVAIIKKAKAMKEAK
                     QFINFILSSDVQNAFGQSTSNRPIRRDAQTSHEMKPLDEIITLKEDYGYVTRHKKKIL
                     NTYNRLHEALERGK"
     gene            12304..13701
                     /locus_tag="VHC05_001189"
     CDS             12304..13701
                     /locus_tag="VHC05_001189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent succinate-semialdehyde
                     dehydrogenase"
                     /protein_id="HEQ5402501.1"
                     /translation="MAYQTIYPYTNEVLHTFDNMTDQGLADVLERAHLLYKKWRQEDH
                     LEERKAQLHQVANILRRDRDKYAEIMTKDMGKLFTEAQGEVDLCAGIADYYADKADEF
                     LMSTPLETDSGQAYYLKQSTGVILAVEPWNFPYYQIMRVFASNFIVGNPMVLKHASIC
                     PRSAQSFEELVLEAGAEEGSITNLFISYDQVSQVIADKRVVGVCLTGSERGGASIAEE
                     AGKNLKKTTLELGGDDAFIILDDADWDQLEKVLYFSRLYNAGQVCTSSKRFIVLDKDY
                     DRFKELLTKVFKTAKWGDPMDPETTLAPLSSAQAKADVLDQIKLALDHGAELVYGGEA
                     IDHPGHFVMPTIIAGLTKDNPIYYQEIFGPVGEIYKVSSEEEAIEVANDSNYGLGGTI
                     FSSNQEHAKAVAAKIETGMSFINSGWTSLPELPFGGIKHSGYGRELSELGFTSFVNEH
                     LIYIPNKTNNSNTKV"
     gene            13803..15599
                     /gene="uvrC"
                     /locus_tag="VHC05_001190"
     CDS             13803..15599
                     /gene="uvrC"
                     /locus_tag="VHC05_001190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HEQ5402502.1"
                     /translation="MNELIKHKLELLPDSPGCYLHKDKEGTIIYVGKAKNLKKRVRSY
                     FRGSHDTKTELLVSEIVDFEYIVTESDTEALLLEINLIQKNMPKYNIKLKDDKSYPFL
                     KITNESFPRLVITRYIKKNDGLYFGPYPDSYTANEVKKLLDRIFPFKKCKNPINKVCF
                     YYHLGQCCAHTICHTDKAYWDRLIDDVKHFLNGKDDKIIEDLRSKMLAASEEMAFERA
                     AEYRDLISGIATMRTKQRVMSKDLQDRDIFGYYVDKGWMCVQVFFVRQGKLIQRDVNL
                     FPYYNDAEEDFLTYMGQFYQDKQHFIPKEVFIPEAIDEELVAAIVPTKIIKPKRGEKK
                     QLVALATKNARVSLQQKFDLLEKDIKKTSGAIENLGQLLRIDKPVRIEAFDNSNIQGT
                     SPVAAMVVFVDGKPSKKDYRKFKIKTVVGPDDYASMREVLFRRYSRVKKEGLQAPNLI
                     IVDGGVGQVNVAKDVIEKQLGLTIPVAGLQKNDKHQTHDLLFGNPLEVVPLPRRSEEF
                     FLLHRIQDEVHRFAVTFHRQVRRKNSFSSTLDHISGLGPKRKQLLLRHFKTITAIASA
                     TSEEIQALGIPKTVVEAIQQQITDNKNDRSSP"
     gene            15783..16385
                     /locus_tag="VHC05_001191"
     CDS             15783..16385
                     /locus_tag="VHC05_001191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HEQ5402503.1"
                     /translation="MKFLELNKKRHAIKTFNDQPVDYEDLRTAIEIATLAPSANNIQP
                     WKFVVVQEKKAELAKGLPLANKVQVEQAQYVVALFSDTDLALRSRKIARIGVKSLPDD
                     LIGYYMETLPPRFAAFNEVQTGEYLAINAGIVAMNLVLSLTDQKIASNIILGFDKSTT
                     NEILDIDPRFRPELLITVGYSDEKPEPSYRLPVDEVIEIR"
     gene            16510..17919
                     /gene="pepV"
                     /locus_tag="VHC05_001192"
     CDS             16510..17919
                     /gene="pepV"
                     /locus_tag="VHC05_001192"
                     /EC_number="3.4.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase PepV"
                     /protein_id="HEQ5402504.1"
                     /translation="MTTIDFKAEVDKRKEAMLADLVDLLRINSERDDRLADDQHPFGP
                     GPVKALEHFLAMAERDGYKTRNIDNYAGDFEFGQGDEVLGIFGHLDVVPAGSGWDTDP
                     YEPVIKDDRIYARGSSDDKGPTMACYYALKIIKELGLPVSKKVRFIVGTDEESGWGDM
                     DYYFAHNGLKNPDFGFSPDAEFPIINGEKGNITEYLHFAGDNKGAFVLHRFQGGLREN
                     MVPESATAVITAPHDLDVLEAALEQFLSEHGVKGSMKATDGKIEVTIIGKSAHGSTPE
                     AGVNGATLLAKFLNQFTFEGAAKDYLHVAGEVLHEDFAAEKLGLAYTDDRMGALSMNA
                     GVFTFDSQSADNTIALNFRYPKGTDAATLKSGLEKLPGLTKVSLSEHEHTPHYVPMDD
                     ELVTTLLAVYEKQTGLKGYEQVIGGGTFGRLLERGVAFGAMFPGDENTMHQANEYMPL
                     ENIYRSAAIYAEAIYELIK"
     gene            complement(17987..19363)
                     /gene="mnmE"
                     /locus_tag="VHC05_001193"
     CDS             complement(17987..19363)
                     /gene="mnmE"
                     /locus_tag="VHC05_001193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002888396.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="HEQ5402505.1"
                     /translation="MSITKEFDTITAISTPLGEGAIGIVRLSGTDALAIAQSVFKGKN
                     LEQVASHTINYGHIIDPNTGTIVDEVMVSVMLAPKTFTRENVVEINTHGGIAVTNEIL
                     QLLIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMTIAVKQLDGSLS
                     QLINDTRQEILNTLAQVEVNIDYPEYDDVEEMTTALLREKTQEFQSLLENLLRTAKRG
                     KILREGLSTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNIKGVPLKL
                     VDTAGIRETDDLVEQIGVERSKKALQEADLVLLVLNASEKLTDQDRALLNLSQDSNRI
                     ILLNKTDLEQKIELEQLPADLISISVLTNQNINLIEDRINQLFFDNAGLVEQDATYLS
                     NARHISLIEKAVQSLEAVNDGLALGMPVDLLQVDLTRTWEILGEITGDAAPDELITQL
                     FSQFCLGK"
     misc_feature    19535..19670
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00557"
     gene            19699..20199
                     /locus_tag="VHC05_001194"
     CDS             19699..20199
                     /locus_tag="VHC05_001194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012658294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L10"
                     /protein_id="HEQ5402506.1"
                     /translation="MSEAIIAKKAEQVELIAEKMKAAASIVVVDSRGLTVDQDTVLRR
                     SLRESGVEFKVIKNSILTRAAEKAGLDELKDVFVGPSAVAFSNEDVIAPAKVINDFTK
                     TADALEIKGGAIEGAVSSKEEIQALATLPNREGMLSMLLSVLQAPVRNVAYAVKAVAE
                     NKEGAA"
     gene            20264..20629
                     /gene="rplL"
                     /locus_tag="VHC05_001195"
     CDS             20264..20629
                     /gene="rplL"
                     /locus_tag="VHC05_001195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="HEQ5402507.1"
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAAAAA
                     GGAEEAAKDSFDVELTSAGDKKVGVIKAVREITGLGLKEAKGLVDGAPANVKEGVAAA
                     EAEEIKAKLEEAGATITLK"
     gene            20927..21547
                     /locus_tag="VHC05_001196"
                     /pseudo
     CDS             20927..21547
                     /locus_tag="VHC05_001196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein"
     gene            21727..22037
                     /locus_tag="VHC05_001197"
                     /pseudo
     CDS             21727..22037
                     /locus_tag="VHC05_001197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000670034.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
     gene            22035..22319
                     /locus_tag="VHC05_001198"
                     /pseudo
     CDS             22035..22319
                     /locus_tag="VHC05_001198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001883480.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            22365..22577
                     /locus_tag="VHC05_001199"
     CDS             22365..22577
                     /locus_tag="VHC05_001199"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402508.1"
                     /translation="MMTDRVMKKPIRGRQLSKRDLYDEEFFRTHFAKIEIESRLKFLF
                     NRANSLEELLLKAKEVNLTIDLKQKM"
     gene            22842..23539
                     /locus_tag="VHC05_001200"
                     /pseudo
     CDS             22842..23539
                     /locus_tag="VHC05_001200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984809.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic (srt) production protein"
     gene            23690..24376
                     /locus_tag="VHC05_001201"
     CDS             23690..24376
                     /locus_tag="VHC05_001201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5402509.1"
                     /translation="MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFK
                     GYDLILLDIMMPNISGTEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIVKP
                     FSLKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYR
                     EYEILELLSRHLYKVFTKEEIYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKT
                     IRGIGYKWDV"
BASE COUNT         7695 a         4314 c         5238 g         7331 t
ORIGIN      
        1 cagttctctt tttagaacca cgtgaactat atgattttcc gcagtatatt ttagatgaag
       61 attatttctt aataactaaa aatatggtat aatattctta ataaatgcag taatacaggg
      121 gcttttcgag actgaagtct agctgagaca aatagtgcga ttacgaaatt ttttagacaa
      181 aaatagtcta cgaggtttta gagctatgct gttttgagtg gtctccattc aacattgcca
      241 atgataactt gagaaagagg gttcatacca gcagtcggat accttcatat tctttttgtt
      301 aaagcgtttt catgttataa taggcaaaag aagagtagag tgatggaacc aacatttttt
      361 tatgattaag ccagatgggg ttaagcgaga gggttagttg gagagatttt gcggtggatt
      421 gaacgcctaa gatttacgtt tgagcgattc gagctaagac aagctagttc gaaatacttg
      481 gctaagcacg acgagacctt ggtgataaac cttttgatcc taaacttaaa gcttacatga
      541 caagtggtcc tgttttaatt gggataattc ttggggacta aggtggtttt gtctttttga
      601 accatgcatg atgagagtaa ccaatcctac ggatgctctt tgcggaacca ttcgtgggaa
      661 ttttgctcag gctcttggtg atgatggagg tatttttaac atggcgtatg ggtctcattc
      721 aagagactct gctaggcgtg agattgtcct ttgggctcat caaagtaatc tcggtagctc
      781 cgctattctc ttgcaagata atccgtaaga aaagataggc aaaggcctac cttttttgtt
      841 ataatagaag gaaagactaa atgtatagga aaatagaatg aacagtcaag atttaaaaaa
      901 acgtcaggag aagattcgta atttctccat tattgcacat attgaccatg gcaaatctac
      961 tctcgctgac cgcattttgg aaaagacaga gacggtttcg tctcgtgaaa tgcaggctca
     1021 gttattggac tccatggatt tggagcgtga gcgtgggatt accattaagt taaacgccat
     1081 tgagcttaat tacacggcta aagatgggga aacctacatt ttccacctta ttgatacccc
     1141 agggcatgtg gactttactt atgaagtatc gcgttcgttg gcagcctgtg agggagcgat
     1201 tttagttgtg gatgcagcgc agggcattga agcgcagacc cttgccaatg tttacctagc
     1261 tcttgataat gatttggaaa ttttaccggt tatcaataaa attgatttgc ctgctgctga
     1321 ccctgagaga gtccgccatg aagtagaaga tgtcattgga cttgatgctt ctgaggctgt
     1381 tctggcgtca gccaaggctg gtattgggat cgaagagatt cttgagcaaa ttgttgagaa
     1441 ggttcctgct cctacgggtg atgtggatgc gcctttacag gccttgattt ttgactctgt
     1501 gtatgatgct taccgagggg taattttgca ggttcggatt gtgaacggta ttgtcaagcc
     1561 tggcgataaa atccagatga tgtcgaatgg aaaaaccttt gatgttacag aagttgggat
     1621 tttcactcct aaggcagttg gacgagattt ccttgcgacg ggagatgttg gttatgttgc
     1681 ggcttctatc aaaacggtag cagatacccg tgtgggggat acggtgactt tagctaataa
     1741 ccctgctaag gaagccttgc atggctacaa gcagatgaac ccgatggtct ttgcagggat
     1801 ttatccgatt gaatcaaata aatacaatga cttgcgtgaa gcgcttgaaa aattacaact
     1861 gaacgatgcc agtttacagt ttgaacccga aacgtcacaa gcgcttggct ttggttttcg
     1921 atgcggcttt ttaggtttgc ttcacatgga cgtgattcaa gaacgtttag agcgtgaatt
     1981 taacattgat ttgatcatga cagcaccgtc cgtggtgtat cacgttcaca caacagatga
     2041 ggatatgatt gaagtgtcta acccttcaga atttccagac ccaacccgtg tggcttttat
     2101 tgaagagcct tatgttaaag cgcaaatcat ggtgccacaa gagttcgtag gggctgttat
     2161 ggaattatcg cagcgcaagc gtggtgattt tgtgaccatg gattacattg atgataaccg
     2221 tgtcaatgtg atttaccaaa tcccgctggc tgaaattgtc tttgatttct ttgataaatt
     2281 gaaatcctca acgcgaggct atgcgagttt tgattatgac atgtcagaat accgcaggtc
     2341 acaattggtg aaaatggaca ttcttttgaa cggtgataag gtcgatgcgc tcagctttat
     2401 tgttcataaa gaatttgctt atgaacgcgg gaaaattatt gttgagaaat tgaaaaaaat
     2461 cattccacgt caacagtttg aagtgccgat ccaagccgct attggtcaaa aaattgttgc
     2521 gcgttcagac atcaaggccc ttcgtaaaaa cgttttagcg aagtgttatg gcggtgacgt
     2581 gtctcgtaaa cgtaaattgc tcgaaaaaca aaaggctggt aaaaaacgga tgaaggctat
     2641 tggttctgtc gaagtccctc aagaagcctt cttgagtgtt ctttcaatgg atgacgatac
     2701 caagaaataa ccaagcttaa tcgcttagtc ttcagaggag aactcttgtg ggtctacatg
     2761 accaaaaaat tgattatctc ataaaaaaaa gaactttaca atctctttca cataacacta
     2821 taatggtatt atagtgttat ctcattatta ggtgagcctg catttaatct tattaaagag
     2881 aaagaggaaa caaaaaccgt gaacaaaaca aaacaaaaca aaacaaaaca aaacaaaaca
     2941 aaacaaaaca aaacatagcc ttctttgtcg ctatggctta acctcagcag ctgctctttt
     3001 gctgaccttt ggaggtgcaa gtgcagttaa ggcggatgca gtaggaagac aacaagtgca
     3061 agatgaactt caaaatcagc gaaaagcttt accacgtctt aaagaatttt ataaggatac
     3121 tccaaactcc ggtgttgaaa atactccgat ttataagtat ttaactgaaa tggaagggaa
     3181 gttaaatcgt tatctggaga ctttagacaa agggttgcac cagttgcaag gtgacaaagg
     3241 agagcctggt gctcaaggcc cagcaggtcc acgtggtgag accggtcccg ctggtgagcg
     3301 aggtgagaaa ggagcccaag gtccacgtgg tgaacaaggc ccgcaaggtc ttccaggtaa
     3361 agatggtgaa gctggtgctc aaggcccagc aggtccaatg ggtcctgctg gtgagcgagg
     3421 tgaaaaagga gaacctggta cccaaggcgc taaaggtgat cgcggtgaaa ccggcccagc
     3481 aggcccacgt ggtgacaagg gtgaaaaagg agaacaaggt cccgccggta aagatggtga
     3541 acgtggtcca ataggtccag ctggtaagga cggccaaaac ggcaaagatg gtctcccagg
     3601 taaagacggc aaggacggcc aaaacggtaa agatggtctc ccaggtaaag acggcaagga
     3661 cggccaagat ggcaaagatg gtcttccagg taaaccggct cctcaaacac cagaggtccc
     3721 tcaaaaacca gatactgcac cacatactcc aaaaacccct cagatccctg gccaatcaaa
     3781 agacgtgaca cctgctcctc aaaacccttc taatagaggt ctaaacaaac tacaaacaca
     3841 aggtggtaat cagctcgcaa aaacaccagc agctcacgac acacacagac aattgccagc
     3901 aacaggcgaa acaaccaatc cattctttac agcagctgct gtagctatca tgacgacagc
     3961 tggagttgta gctgttgcaa aacgtcaaga aaacaactaa tcctcttttt gctacctaac
     4021 tgatggaaag taaaactcag agagaacctc aaggttctct cttttttgaa tcaagatagt
     4081 agctctaggt ataaagtctt gtctgaggtg ctgtgaacaa atcagttacc cttcacctct
     4141 ttttttggta aaatgtaagc actaaaacat caaaaggagt tttctatgga aacatcagat
     4201 gagttaaaac aacgcattgg tgatctttct tacgaggtca cccagcatgc agcaacagaa
     4261 tctcccttta cagggaaata tgatgatttt tttgagaagg gtatctatgt cgatatcgtc
     4321 agtggtgagg tcttgttttc atcactggat aaatttaatt ctggctgtgg ttggcctgcc
     4381 ttctcaaaac ctattgaaaa tcgcatggtc acgaaccacg atgactcttc ttatgggatg
     4441 agacgagttg aggttaaaag ccgtgaagca ggatcgcatt tggggcatgt ctttagtgac
     4501 ggccccaaag aagctggagg cttgcgttac tgtatcaatt cagcagctct taaattcatt
     4561 ccttatgacc agatggaaaa aggaggctat gcccaatggc tcacattgtt tgatgagaca
     4621 taacagggtt tcaaaatgac taaaaaagaa gcgtcagtga ttcccataag cactggattg
     4681 gtgaggcgta cgggtcaatt ttacaagcct ttgtaaaagg tctataatag ggaatgaaaa
     4741 aaggaggtta gtatgtcaac taacttaaga aaacttccag gcctgttact ttgcttattg
     4801 ttagctcttc cagcctggta tttagggcgc ttatttccca ttattggagc acctgttttt
     4861 gctattcttt taggaatgtt gttagccttg ttttatgaac atcgtgacaa ggctaaagag
     4921 ggaattagtt ttacatccaa gtatattttg caaacagcag tggttttgct tggttttgga
     4981 ttaaacctaa cccaagttat ggcagtaggc atgcagtctt tacccattat catttcaact
     5041 attgcgacag ctcttttggt agcttatggc tcacagaaat ggctgggctt agatgtcaat
     5101 acagccacct tggtgggtgt agggtcttcc atttgtgggg ggtctgctat tgcagcgacg
     5161 gctcctgtca ttaaggcaaa ggatgatgag gttgctaagg caatttcagt catttttctc
     5221 tttaatatgt tagcagcttt gctatttcca agtttaggac aattactggg cttatctaat
     5281 gaaggttttg ctatttttgc tgggacagct gttaacgaca cctcttccgt gactgcaacg
     5341 gccacggcct gggatgccct tcaccattcc aatacactag atggcgcaac cattgtcaaa
     5401 ttgactcgca ccttggctat tcttccaatt actttaggtt tatcccttta ccgagcgaaa
     5461 aaagagcacg acatcgttac agaagaaggc ttcagcctta ggaagtcatt ccctcgtttc
     5521 atcctcttct ttttattagc ttccctcatc acgacattga tgaccagctt tggtgtttct
     5581 gccgatgttt tccattccct aaaaacctta tcaaaattct ttatcgtgat ggctatggtg
     5641 gctatcggtt taaatacaaa cctggttaaa ttaatcaaga cgggcggtca ggctatcctt
     5701 ttaggagcta tctgctgggt agctatcacc cttgtcagtt tagccatgca attaagtttg
     5761 ggcatttggt aatcagacac gagaaatcag tttgactgat ttcttttttt gtatcttatt
     5821 tgtgtagaat tgtctacatt ttaaagagaa tagtgcattt taaaaacgtt ttcatttgat
     5881 aaaataaacc tatcgttaaa ccagttcagt aaagacaact ggttgagata agcaattacc
     5941 gtttattcag cggtttttgt taatagagga ggataggaat gaaacgaaaa tttctcattg
     6001 ggagtcacgg cagactagcc agtggtttgc aaagctctat tgacatttta gcaggtatgg
     6061 gacaggcact tgaaaccatt gatgcttatg ttgatgatag tgactacact agccagattg
     6121 atgactttat cgctggggta gcagcagatg agcagggcct tatttttact gatttgttag
     6181 gcggcagtgt gaatcagaaa atggtaaccg ctgtaatgaa cagtggcaaa gacaatatct
     6241 ttttaatcac aaacagtaac ttagccactt tattgtcgtt ggtgttttta aaaccagacg
     6301 aagcgcttac taaagatgaa attgtaaccg ttatcaatga atcgcaagtt cagttagtgg
     6361 atttggtccc tgagacaaat tcagaagatg acttttttga ttaatatctt aatatctagg
     6421 aggaagacaa atgattactc aaattcgtgt tgacgaccgt ttgattcacg ggcaagtggc
     6481 agttgtatgg accaaagagt taaatgcacc gcttttagta gtggctaatg atgaagctgc
     6541 aaaaaatgaa atcacacaaa tgacgcttaa aatggctgtg ccaaacggca tgaaactgct
     6601 tattcgttca gttgaagact cgattaagct ctttaatgat ccacgcgcaa ctgacaagcg
     6661 tatttttgtg attgtcaatt ctgtcaaaga tgcctgcgcc attgctaaag aagttccaga
     6721 cttagaagct gttaatgtgg ctaatgtggg gcgttttgac aaatcagacc cagcaagcaa
     6781 agtcaaagtg acaccaagtc ttttacttaa cccagaagaa atggcagccg caaaggaatt
     6841 agtcagttta ccagaacttg atgtctttaa ccaagtctta ccatcaaata ccaaggtcca
     6901 tttgagccaa ttagtcaact aaagagaggt aaaaaagtat gttagtacca gcaacaatgg
     6961 cagctttagc tgtattgatt tgttttgggg gaaattattt aaccggtcaa agcatgatgg
     7021 aaagacccct agtagttgga ctggtcacag gtcttctttt aggagatatg aaggtcggta
     7081 tcttaatggg ggcctctcta gaagctcttt tcctaggaaa tgtgaatatt gggggtgtta
     7141 ttgcagctga gcctgtaaca gcgactgcca tggcaacaac ctttaccatt atttcacata
     7201 ttgatcaaaa agcagccatg accctagctg ttccaattgg aatgttggca gcctttgtgg
     7261 ttatgttttt gaaaaacgtc ttcatgaata tctttgctcc aatggttgat aaagctgcag
     7321 cagctaacca tcaaggtaaa ctagtgatgc tccactatgg cacttggatt atctattact
     7381 taatcattgc ctctatttct ttcattggta ttttagtagg tagtggacct gttaatgcct
     7441 ttgtggaaca cattcctcaa aatctcatga atggcttgag tgctgcggga ggccttcttc
     7501 cagctgtcgg ttttgccatg ctgatgaaat tattgtggac caacaaatta gctgtttttt
     7561 acctattggg ctttgtctta acagcttatt tgaaattacc agcggttgca gttgctgccc
     7621 taggagcagt tatttgcgtc attagttccc aacgtgatct agaattagac gcaattacta
     7681 gaggtgcaat taataaacaa acaacctttg actctaaaga atcagaagag gaggacttct
     7741 tcgcatgaca tcacaagata atttgactaa agaagaccgt aaaatgcttc gctcagtctt
     7801 ttggcgctca tggacgatga atgctagtcg tactggggca acacaatacc acgcagtagg
     7861 ggttatttac actttactac cagtcatcaa tcgtttttat aagactgata aggataaagc
     7921 agaggcactg gtccgtcata caacatggtt caatgccacc atgcacatca ataactttat
     7981 catgggtctt gtggcatcga tggaaaagaa aaacagtgaa gatcctgatt ttgatgctag
     8041 tgctatcact gctgttaagg cttcgttgat gggacctata tctggagttg gagattcctt
     8101 cttctgggga attttaaggg ttattgcggc aggtatcggg atttccttgg caagtgcagg
     8161 ctcagccatg ggagctgttg tcttcttact cttgtacaat attcctgctt ttattattca
     8221 ctactatagc ctttatggtg gttattctgt aggtgcagga tttatcaaaa aactttacga
     8281 atctggtggt ataaaaatcg tcactaaaac ctcaagcatg cttgggttaa tgatggtagg
     8341 ctcaatgact gcttcaaatg taaaatttaa aacgattctt acagttgctg cgaaaggtgc
     8401 caaagaagca gcttctattc aagattacct tgaccaattg tttattggta ttgtaccatt
     8461 aatggtaaca ctagcagctt tttggcttct acgaaagaaa gtgaatatca actggattat
     8521 gtttggtatc atgttccttg gcattatcct tggactttta ggtatttgct aataatctcc
     8581 tagcaataaa ggtaagtaag acaagttttc ttgttttgct tacctttttc cttttaagat
     8641 gatgagactt gttttgatga aaaacgtagt agcattaaga aatttgttat aatgaaggga
     8701 gcttaagatg cgaggtgaac aggtggaaga acattttaaa aaacaattac aagatgatat
     8761 ttctagacat ttttcgtacc aatcgttaat gttatcattg ttgctaattg gtctttttat
     8821 tattttttca ttagcgccac aacaattagg cctctatcgt gatatcaatg ccactgcaac
     8881 ccgttatcac cgtttgatta gcaaacaaga agccttgcta gatgaattag ggaaaaatag
     8941 cttactacct tttttaaata aaaacctcag cactgctgat ttaagcaagc actattttca
     9001 tttgcgccgt agcagccaaa cgtcaccaga acttttacta ttttcaccta atcaaggcct
     9061 tttatttgct agtaacccac atttaggaaa tgtttttagt aaatctgttt atattcaaga
     9121 agtcttgaga gcagctcatc ctccaaaaac cttgtttaaa gttgctatgg atagtgaaga
     9181 tggtcactac ttgatgatca ttaagccaat gatagatcaa aaccaactaa agggatatgc
     9241 ttttttagtg atgagtggca aagattttct tcatcctaca aaaacattga cgtcagagtt
     9301 ggtcattgct gataagctgg acaacacggt tacgttttcc aatcgtgagt ttatagcatc
     9361 tagtctagat aagatcaata gccagtattt acaccattat tttgtttttc aagataatcg
     9421 agcctttatc acaagaaagg ttgccttaca aggaggcctt tggctttaca tgtataggcc
     9481 cttgattcca atggtatcgg tgatgttatt ttcacttatt tcatcagctg ttatctttgt
     9541 gattttgcaa cgtaaatcaa gtggtttagc taaccgaatt gcagctaaaa attcaagagc
     9601 aatcaatcaa atggttagag atatgagtgc gatctctcgg caagaaaaaa gacgtattga
     9661 ccttgagagt caagatgaat ttcaatattt atctgatcaa atcaatcaaa tggtagagcg
     9721 attgcaacag ttacatgata aaacgttaga tttggaaact caaaaattat tatttgaaaa
     9781 acggatgtta gaagctcaat tcaatccgca tttcctctac aatacgctag aaaccatttt
     9841 gattacgagc cattatgatt ctgccctaac agaaaaaatt gttatccaat tgacaaaatt
     9901 gttgcggtat agtctcacgg attctagcaa acctgtcttg ctcaaagatg atttaagtgt
     9961 catcgagtct tatttagtga ttaatcaggt gcggtttgaa gaattgcaat atagcattaa
    10021 cctatcccca gaccttgata gtcttgcagt gcctaaattg ttcttgttac ctttgataga
    10081 aaatgccatc aaatatggct tgaaagaacg acacgatgtc aagattaaca ttgcttgtta
    10141 ttatcaagat gaccacatta ttttttctgt gagagataat ggttcgggaa ttgatgctca
    10201 tcaccaaaaa gtgattcgag agcaattgga agctggagag tcacaccatg ggttaattaa
    10261 ctcttatcgt cggcttaagt atcatttttc agaagtatcc ttggtttttg atcaaggtga
    10321 taaacagttt aatgttagtt accatgttaa ggagtagtct atgtacaaat tagtcattat
    10381 tgaagatgaa catattatta ggaaatggtt gcgatacgct attgattata aagctttaga
    10441 tattttggtc attggcgagg ctaaagatgg caaagaagga gctgttttaa tcaaagagag
    10501 tcaaccagat atcgttttaa ccgatattaa catgcccatc atgacagctt ttgacatgtt
    10561 tgaagcaaca aaagatcaaa cttacgccaa aattatttta tctggctatg ctgattttcc
    10621 aaatgcaagg tctgccatac actacggtgt acttgaattt ttaacaaaac cgattgaaaa
    10681 agcagctctt tgggaatgtc ttcaaaccat tattgctaaa atagaaaagc aaaaggggtc
    10741 taatcaaaaa acagatgctt gcgtctatat tcccttaccc cagatgactg atcagattcc
    10801 tgaagtagtc aaagatattt tggagtgggt acatgctcat tttcaagaca aaatcagcac
    10861 gagccgccta gctcatgact tagggtatag tgagagttat atctatcaaa atatcaaaaa
    10921 gcatcttcag atgcctttaa gtgattacat taatcaatat cggattaatc aggcaattca
    10981 attgatgcaa caagaaccag atttaatggt atatgaaata gcacaagctg taggtattta
    11041 tgactatcgc tattttgata gggtttttaa aaagtatcta ggacaaactg taaaggcttt
    11101 taaagaagag cattttatga aagataccga taggagtaag ccatgttaaa actcaaacgc
    11161 aaatggctat taagcttttt gttagtaata attattctag caatcgttaa cgttgcaatg
    11221 tatatattct catcgtcaaa aaaagatagt gctaaagaat tagttatctt gactcctaat
    11281 agccaaacta ttttaacagg gactattcca gcctttgagg aaaagtatgg ggttaaagta
    11341 agattaatcc aaggtgggac gggccaactt atcgatcaat taggtcgaaa agataagcca
    11401 ttaaacgctg atattttctt tgggggcaat tacactcaat ttgaaagcca taaagattta
    11461 tttgaatctt atgtttctcc gcaggtttct actgtcattt cagattacca attgcctagt
    11521 catcgtgcaa ccccatatac gatcaatggc agtgtactga ttgttaataa cgaattagca
    11581 agaggacttc atattaccag ttatgaggat ttgctacaac cagctttaaa aggcaaaatt
    11641 gcttttgctg acccaaatag ctcatctagc gctttttcac aattaacaaa catcttactg
    11701 gctaaaggag gctatacgag ctcagaagct tgggagtatg tgaaacgttt attactgtct
    11761 atgaattcta tcagagcaac aagttcttca gatgtttacg aatctgttgc agaaggtaaa
    11821 atgattgttg gtttgaccta tgaagatcct tgcatcaatc tgcaaaaaag cggtgcaaac
    11881 gtttcggttg tttatccgga tgaggggaca gtatttgttc cgtcatcagt cgctattatc
    11941 aaaaaagcaa aggcaatgaa agaagctaag caatttatta attttatttt atcatcagat
    12001 gtacaaaatg cctttgggca gtcaactagt aatagaccta tccgacgaga tgctcaaacg
    12061 agtcatgaaa tgaaaccatt agatgaaatt attactttaa aagaagatta cggatatgtt
    12121 actagacata agaaaaaaat attgaatacc tataatcgac tacatgaagc attagaaaga
    12181 ggaaagtaga ctctaggctt gttgttgcta tactagtagt gttacaaaat agcgtagtca
    12241 ttttttgaaa tcgatttcat aatctggtag actaaggtta tcacgaaaag gaggctatat
    12301 gtgatggctt atcaaactat ttacccttat acaaatgaag tccttcatac atttgataat
    12361 atgaccgatc aaggtttggc agatgtcctt gaaagagctc accttctcta taaaaaatgg
    12421 cgccaagaag atcatttaga agaacgtaaa gcccagcttc atcaagtggc taatattctt
    12481 cgccgtgacc gcgataaata cgctgaaatc atgaccaaag acatgggaaa attgttcaca
    12541 gaagcccaag gtgaagtaga tctttgtgcc ggtattgctg attactacgc tgataaggca
    12601 gatgaatttt tgatgtctac gccactagaa acggattctg gtcaagctta ctatttgaaa
    12661 caatcaacag gtgttatcct agctgttgag ccttggaatt ttccttacta tcaaatcatg
    12721 cgggtttttg cgtcaaactt tattgttgga aacccaatgg ttttaaaaca cgcttctatt
    12781 tgcccacgct ctgcccaatc tttcgaagaa ttagttcttg aagctggtgc tgaagaaggt
    12841 agtattacca atttgtttat ttcttatgac caagtatcac aagtgattgc tgataaacgt
    12901 gtggttggtg tctgcttgac aggttccgaa cgtggaggag ctagcattgc agaagaagct
    12961 ggtaaaaact tgaaaaaaac aacccttgaa ttgggtggcg atgatgcctt tattatcctt
    13021 gatgacgcgg attgggatca attagagaag gtgctttact tctctcgtct ctacaatgca
    13081 ggacaagtat gtacctcatc gaaacgtttt atcgtgcttg acaaagacta tgaccgtttc
    13141 aaagagttat taacaaaagt cttcaaaaca gctaaatggg gtgacccaat ggatcccgaa
    13201 acgacgttgg cgccattatc atcagctcaa gctaaagcag atgttcttga ccaaattaag
    13261 ttggccttgg atcatggtgc ggagttggtt tatggtggtg aagcgattga tcatccaggt
    13321 cattttgtca tgccaaccat tattgctggc ctcacaaaag acaaccctat ttactatcaa
    13381 gaaatctttg gcccagtcgg tgaaatctac aaagtgtctt ctgaagaaga agcgattgaa
    13441 gtggcgaatg attctaacta tggccttgga ggtactatct ttagtagcaa tcaagaacat
    13501 gcgaaagccg tagctgctaa aattgaaact ggtatgtctt ttatcaactc aggctggaca
    13561 agtcttccgg aactcccatt tggtgggatt aaacattcag gctatggccg tgaattgagt
    13621 gagcttggct ttacatcttt tgtgaatgaa caccttatct atattccgaa taaaacgaat
    13681 aatagcaata cgaaagtttg atctagattg ttaaaggaga tctgctcgcc ttaataaaca
    13741 atcaaggcgt tacactcttc ttttttaaag tcaaaatttt aaaaatttga taaactagta
    13801 acatgaacga actgattaaa cataaactag aactcttacc agacagccct ggctgttact
    13861 tacataaaga taaagaagga actattatct atgtcggtaa ggccaagaat ttgaaaaaac
    13921 gcgtccgatc ctattttcgt gggagccatg ataccaaaac agagttatta gtatctgaga
    13981 ttgtagattt cgaatatatt gtaacagagt cagataccga agcgcttttg ttggaaatta
    14041 acttgattca aaaaaatatg cctaagtaca acatcaagtt aaaagatgat aaatcttatc
    14101 cctttctcaa aatcacaaat gagtcttttc ctcggttagt gattacaaga tatattaaga
    14161 aaaatgatgg attgtacttt gggccctacc cagattctta tactgctaat gaagttaaaa
    14221 agttattaga taggattttt ccatttaaaa agtgtaaaaa tcctatcaat aaggtctgtt
    14281 tttattacca tttaggccag tgctgtgctc ataccatttg tcatacagac aaggcctatt
    14341 gggatcgttt aattgatgat gttaagcact ttttaaatgg taaagatgac aaaattattg
    14401 aagatcttcg ttctaagatg ttagcagctt ctgaagaaat ggcatttgaa cgtgccgctg
    14461 aatatcgaga tttgatttca ggtattgcca ccatgcgcac caagcagcgg gtgatgagca
    14521 aggatttgca agatagagat atctttggct attatgttga taagggatgg atgtgtgtcc
    14581 aagttttctt tgtgcgtcaa gggaaattaa ttcagcgtga tgttaacctt tttccctatt
    14641 ataacgatgc agaagaagat ttcttaactt atatggggca attttaccaa gataaacagc
    14701 atttcatccc taaagaagtc tttattccag aagctattga tgaagaactg gtagccgcta
    14761 ttgtgccaac caaaatcatc aaacccaaac gcggtgaaaa aaaacaactg gtagctttgg
    14821 ctactaagaa tgctcgtgtt agtctgcaac aaaaatttga tttattagaa aaagatatca
    14881 aaaaaacgag tggtgctatc gaaaatttag gtcagttact taggattgac aagcctgtgc
    14941 gcattgaagc ctttgataat tctaacattc aagggacaag tccagttgcg gctatggttg
    15001 tttttgttga tggcaaacct agtaagaaag attatcgtaa atttaagatt aaaacagtgg
    15061 tgggaccaga tgattatgcc agtatgagag aagtgctttt tcgaaggtac agtcgggtga
    15121 aaaaggaggg actgcaagct cctaacttga ttattgttga tggaggcgtt ggacaagtca
    15181 atgtggccaa agatgtgata gaaaaacaac ttggactcac tattcctgtt gcgggacttc
    15241 aaaaaaacga taaacaccag acccatgatt tgctttttgg aaacccgctt gaagttgtac
    15301 cgttgccgcg ccgttctgaa gagtttttct tactgcatcg gattcaagac gaagtgcatc
    15361 gctttgcagt tacatttcat agacaagtgc gacgtaaaaa ttctttttca tcaacattag
    15421 atcatatttc agggcttggc ccaaagcgaa aacagttatt actaagacac tttaaaacca
    15481 taacagcgat tgcatcagct acctctgagg agattcaagc tttaggtata cctaaaacag
    15541 tagttgaagc aatacagcaa cagataacag acaataaaaa tgatagatcg tctccttaaa
    15601 taagtgttat gttttcagta ctgatgaggt aaaaaggcgc tacttgttac gcacgacatt
    15661 tcagttcgtt attttgaaac tttcagaaag ttgcgaagtg tagtgatttt atgattttaa
    15721 aaactatttt atggtaaaat aaaatggtat taaaaaaaca gatttagata ggaagttttg
    15781 aaatgaaatt tctagagtta aacaaaaaac gccatgccat taagaccttt aatgaccagc
    15841 cagttgacta cgaggatttg cgaacagcca ttgagattgc aaccttagca cctagtgcca
    15901 ataacattca accttggaaa tttgtagtcg ttcaagagaa aaaagctgag ttagcaaaag
    15961 ggttacctct agcaaataaa gtgcaggttg aacaggctca atatgtagtg gcgctatttt
    16021 cagacactga tttagcttta cgttctcgta aaattgcccg tatcggtgtc aaatcgttac
    16081 cagacgactt aattggttat tatatggaga ctttgccacc acgttttgct gcttttaatg
    16141 aggttcaaac cggtgagtac ttagctatta atgcaggcat tgtggctatg aacttggtgt
    16201 tatccttgac ggatcaaaag attgcttcca atattatcct tggttttgat aagtcaacga
    16261 ccaatgaaat tttagacatc gatccgcgtt ttcgtccaga attattgatt actgttggct
    16321 atagtgacga gaaaccagaa ccaagttatc gtttgcctgt tgatgaagtc atcgaaataa
    16381 gatagagtca ggacaattag ttaaatgtaa tgtccagatg cgctactgag cgaccactat
    16441 tgttagactg atactatttt ggcttatttt aagttaaaca ttatccctaa aacgaataag
    16501 gagagtataa tgacaaccat tgattttaaa gcagaagttg acaaacgtaa agaagctatg
    16561 ctagcagatt tagttgacct attacgcatt aattcagaac gcgatgacag attggccgat
    16621 gatcagcatc cctttggccc aggtccagtt aaggctttgg agcacttcct cgcaatggct
    16681 gagcgtgatg gctacaaaac gcgtaatatt gataactatg caggtgactt tgaatttggt
    16741 caaggtgatg aagtactagg aatctttggt caccttgatg ttgtgccagc tggtagcggt
    16801 tgggatacag acccttatga gccagtgatt aaagacgatc gcatctatgc gcgtgggtct
    16861 tcggatgata agggaccaac catggcgtgc tactacgctc tgaaaatcat taaagaattg
    16921 ggtcttcctg tgtctaaaaa agttcgtttc attgttggta ccgatgaaga atctggctgg
    16981 ggggatatgg attattactt tgctcataat ggcttgaaaa atccagattt tggtttctca
    17041 ccagatgctg aatttccaat tatcaatggt gagaaaggaa atatcaccga atacctccat
    17101 ttcgctggtg acaacaaggg cgcttttgtg cttcatcgct tccaaggtgg gttgcgtgaa
    17161 aacatggtac cagaatctgc aacagctgtc attacggcac cgcatgacct tgatgtgcta
    17221 gaagcagcct tggagcaatt tttatcagaa catggtgtta aaggttctat gaaggctact
    17281 gatggtaaaa ttgaagtgac cattattggt aagtctgctc acgggtcgac tccagaagcg
    17341 ggtgttaatg gtgccacctt gttggctaaa ttcctgaatc aatttacctt tgaaggggct
    17401 gctaaggatt atttacatgt ggcaggtgag gtgcttcatg aagactttgc ggcagaaaaa
    17461 ctaggccttg cttataccga tgaccgtatg ggagccctga gcatgaacgc aggtgtcttt
    17521 acctttgata gtcaatcagc tgacaatacc atcgccttga atttccgtta tccaaaaggg
    17581 actgatgcgg caaccttaaa atcaggattg gaaaaattac caggtttaac taaggtaagc
    17641 ctttctgagc atgaacatac acctcattat gtgccaatgg atgatgaatt agtaactacc
    17701 ttacttgctg tttacgaaaa acaaacaggt cttaaaggct acgaacaagt tatcggcgga
    17761 ggaacctttg gtcgtttgct agaacgtggt gtggcctttg gagcgatgtt cccaggcgat
    17821 gaaaacacta tgcaccaagc taatgaatat atgcctttag aaaatattta tcgctcagca
    17881 gctatttatg ctgaagcaat ctacgaatta attaaataag atgcttatga cagcaaaaag
    17941 agctggaaca ctgttccagc tcttttgtga tgattagaga atggtcttat ttaccaagac
    18001 aaaattggct aaagagttgg gtaatgagtt catcaggagc agcatcccct gtgatttctc
    18061 cgagaatttc ccaagttctg gttaaatcaa cctgtagtaa atcaactggc atgccaagcg
    18121 ccaagccgtc attgacagct tctaaactct ggactgcctt ttcaatcaaa gaaatgtggc
    18181 gggcatttga caggtaagtg gcatcttgtt ctactagtcc agcattatca aagaagagct
    18241 ggttgatacg atcttcgatc agattaatgt tctggttggt taacaccgaa atagaaataa
    18301 ggtccgctgg caactgttcc aattcaatct tttgttccaa atctgtttta ttcagcaata
    18361 taatgcggtt actgtcttga ctgagattta acaaagcccg gtcttggtca gtcagttttt
    18421 cagaagcatt cagcacaaga agaacaaggt cagcttcttg aagagctttt ttagaccgtt
    18481 caactccgat ttgttcgacc agatcatctg tctcacgaat accggccgta tcgacaagtt
    18541 ttagaggaac tcccttgata ttaacgtatt cttcaatgac atctcgggtg gttcctgcaa
    18601 tatcagtcac aatagccttg tcttctcgca acaaattatt aagtaagctt gacttaccga
    18661 cgtttggacg accaataata gctgttgata agccctcacg cagaatttta ccgcgtttag
    18721 ctgttcgaag gagattttcc aaaaggcttt ggaattcttg tgttttctca cgtagcagag
    18781 cagtggtcat ttcttccaca tcgtcgtatt cagggtagtc aatattgact tcgacttgag
    18841 ctaaggtgtt gagaatttct tgtcgggtgt cattgataag ctgggaaagg gagccatcca
    18901 gttgcttgac tgcaatcgtc atagccttgt ctgttttggc acgaataatg tccatgacag
    18961 cctcagcttg agtcaaatca acacgaccat ttaagaaggc acgtttggtg aattcgccag
    19021 gctctgccat tctagcgcct tggcgaatca atagttgcaa gatttcattt gtcacagcaa
    19081 taccaccgtg cgtattgatt tcaaccacat tttcacgggt aaaggttttg ggagccagca
    19141 tgactgacac cataacctca tcgacaatag ttcctgtgtt aggatcaatg atatggccat
    19201 agttaatggt gtgtgaagct acttgctcta agttctttcc cttaaaaaca gattgtgcaa
    19261 tggcaagcgc atctgtcccg gatagacgaa caatgccaat agctccttca ccaagagggg
    19321 ttgaaatggc ggtaattgta tcaaattctt tagttatact catgccctct attttaaatc
    19381 aagtcctagt agaaagcaag gtattatttt gtatagaaaa taggactagc accattttga
    19441 gtttagctaa tactaaaaaa gaataaatgt aaaaaaatca tttttttaat aatttttatt
    19501 gacaatagta ttataaaaga atataatgat ataggttttg ataaaaaact gacctaagac
    19561 agcaggggag catgctcata atattcctgc cgaggcacaa aacgtgatta aagagaataa
    19621 cgtatttgta ctttcgtgtc taggtttagg tgcgattttt ttgtacctag cccaaaaata
    19681 aaaacggagg taaaactaat gagtgaagca attattgcta aaaaagctga acaagtcgaa
    19741 cttattgctg agaaaatgaa agcagcagca agtatcgttg ttgttgattc acgtggtctt
    19801 acagttgatc aagatactgt tcttcgtcgt tcacttcgtg aaagtggcgt tgagttcaaa
    19861 gttatcaaaa actcaatttt gactcgtgca gctgaaaaag caggtcttga tgagttgaaa
    19921 gatgtattcg taggaccatc tgcagtagca ttttctaacg aagatgttat cgcaccagct
    19981 aaagttatca acgactttac taaaactgct gacgcacttg aaatcaaagg tggtgcaatc
    20041 gaaggcgctg tttcttcaaa agaagaaatc caagcacttg caacattgcc aaaccgcgaa
    20101 ggaatgcttt ctatgcttct ttctgtactt caagctccag tccgcaacgt tgcatacgct
    20161 gtcaaagctg ttgcagaaaa caaagaaggc gctgcttaag acgtctcaga gtagcttaag
    20221 gctacgctta acattttaaa ttaattattt ggaggaaatc acaatggcat tgaacattga
    20281 aaacattatt gctgaaatta aagaagcttc aatccttgag cttaacgatc ttgtaaaagc
    20341 tatcgaagaa gaatttggtg taactgcagc tgctcctgta gctgctgcag ctgctggtgg
    20401 tgctgaagaa gctgctaaag attcattcga cgttgaattg acatctgctg gcgacaaaaa
    20461 agttggcgtt atcaaagctg ttcgtgaaat cacaggtctt ggtcttaaag aagctaaagg
    20521 tcttgttgat ggagcacctg ctaacgttaa agaaggcgtt gctgctgcag aagctgaaga
    20581 aatcaaagct aaacttgaag aagctggagc aacaatcact cttaaataag aagcagatag
    20641 caatttgaga gcgaaatccc gatttatcag ttttttagag cttatagcga tttgaagaaa
    20701 ctgataaaat gatttggttt cttgccaaaa atcctgccaa aaattttttg gcaggatttt
    20761 tattttctat aaaaattaag ctgagtagag tggctattct atttatatgt gtctagtaat
    20821 aattttttta tgtgaacgag aacattttaa taagtgttct cgttttttta tgttcaggag
    20881 gaaaatcatg caaatgaatg aacagtcatc acgacaaatg gtgattgcca tctatctcat
    20941 ttattccaac tcaaaatgat agtactcctt ggctgttcca agtcgaaatt gttagtgatt
    21001 aagaaaacct acgagactat ggtttgatcg atgaaggcca gcagtctccc agtgaaaaag
    21061 ggcgtttggc taataagatt tatttaggaa agttggaaca tgattccacc ccagtcttaa
    21121 gttcagacgg gggtagtcta aaaaaacacg ggaccagtct caaaaacaga caagccccgt
    21181 gttaaattca gcccctagtg agactgaaaa gagtgaaact gaaggtagtg aaactaaaga
    21241 gagtaattta gtcattgagg acgaggagga aagaaaggag tgcactagtg tgaaaaagac
    21301 tgagggtcac tttacccgtc aagttgatca ggtcaccaaa tatgacaaag attatatttg
    21361 gagtttggtt cattcccaat tacgtgaagg tggtttatca caagctgcta gtgacttagt
    21421 catgagctat tttgaagaac gctatgctta tgcgctggaa cacatacggt tcgcaagaac
    21481 agctgaagct attgcggaat atgtctttaa tggtgtctta tccgaatgga ccaagcaact
    21541 aaggtgacaa gaagcgaagt gaggtgagta agatgttttg gtggctatta ttaggtgttt
    21601 ggggtctaag gacaatttgg ttgattattg aagttatcac tgcaccagaa atggaagatt
    21661 atagttgagt aaggacgtta cataagcagt aaggtccttt tattttgtca gaaaggaatg
    21721 agagatatga agtttttaga tttgtttgca ggaattggag gctttcgatt gggtttaatt
    21781 aatcagtgcc atgagtgtat tggcttttgt gagattgata agtttgcgag gcaatcttac
    21841 aaagccatct atgagaccga aggagaaata gaatttcatg acattagaca agtcacagac
    21901 caagacttta gacaacttag agggcaagtg gatatcatct gcggtggttt ttcccttgtc
    21961 aagcattttc actcgcaggc agacgactgg gatttgaggg cactaggaga actctcttct
    22021 ttgagattac tcgagcgact catacagaca aagatcatat tcataatcac atcttaatca
    22081 acgccattga ctgtaattca gataaaaagt tgatatggaa ttatgccttg gaacgaaacc
    22141 ttcgtatgat ttcagaccgc atttctaaaa tggctggggc gaaaattatt gaaaagcatt
    22201 tctcttaccg tgactatcaa aaatatagag cgactagcca taagtttgaa ctaaagcaac
    22261 gtctttattt tttgatgcag cagtcaaagt tctttgatga ttttttagaa aaagcagagt
    22321 aattacatgt tcatattgat tttagtcaga agcatagcag attcatgatg acggatcgag
    22381 taatgaaaaa accaattcga ggtcgtcaac tcagtaaacg agatttatat gatgaagaat
    22441 tttttcgtac acattttgcc aagatagaaa ttgaaagtcg attaaaattt ttgtttaacc
    22501 gtgccaattc attagaggag ctactattaa aagcaaaaga agtgaatcta accattgact
    22561 taaaacaaaa aatgtaactt ttatcctaga agaagatact caaaagataa gtttaggtca
    22621 taaaaaaata agcgataaga aattatatga tgtcaatttt ttcaagatta ctttaaaaat
    22681 aaggaagtcg gtgtttcaga tcgattagaa agtctacaga aacagtacat gcttttcaag
    22741 aagaatgaga taaagaggag gtatccactg aagagagtaa ggaagtcttc aagaaataca
    22801 aggggcaacg agatgccatc catgagtttg aagttgaact tgtggaacat caaattgaga
    22861 ggttaattgc tgaggacatt tatatcaagg tgtcttttgg tgtaaagcag agtggtctta
    22921 ttttcattcc taactatcaa ttggatatta ggaaagaaga aaatcataaa aaatataaag
    22981 tctatattcg tgagaccgca caattcttca tttacaacaa ggaggcgtct aaacttaatc
    23041 gctatgtgcg agggcgtgag ctcatttacc agttaaccaa tgatagcaag agtattccaa
    23101 aaagaagacg accaaaacca ttgatacact taagaaaaag attgaagaaa taagtctcct
    23161 cattgagtta gatacggaga ataagcctta tcaagatatt aaagatgaca ttgttaaaga
    23221 tatggctcaa ttagatttga ccattacaga gttgcaggac catattgctc atctcaataa
    23281 ggttgcggag gtcttgctta atctgaacaa caacgatata gagaaccgcc gtttggccag
    23341 atatgactat gccaagatga acttgactgc agctataaaa atagaagaag ttgagaaaga
    23401 gattgaaact tctcaaaatg aacttaatat atccatagat gagtatgaat atctagtaag
    23461 aaggttggaa aagtttggag agatcttgag tgatagcaaa attatcgata cttctcgaaa
    23521 tgaaatacaa tgggagtaat tatgatataa tttgggtggt agcaattttt atatcagata
    23581 ttaaaatcta gttgatgttt cgtaaataac tatattaaag aaatgattcc tgccgcttac
    23641 attaagaata gtttatttgt aagtatttca ttatttaaaa ggggtaataa tgtataagat
    23701 tttagccata gatgatgata aagaaattct gaagcttatg aagactgctt tggagattga
    23761 aaattatcat gttataacct gtcaagagat agaattacca atagtttttg atgattttaa
    23821 aggatatgat ttgatcttat tggatatcat gatgcctaat ataagtggaa ctgagttttg
    23881 ttataaaatt cgggaagaag ttcattctcc aattattttt gttagcgctt tagatggcga
    23941 taatgaaatt gtccaagctt taaatatagg gggagacgat tttattgtga aaccatttag
    24001 cttaaaacaa ttcgtagcta aagttaactc tcatttgaag agagaagaga gagcaaagat
    24061 aaagaatgag gctgaggaga gagtgaagcg cagttttcca cctatagaaa tctatctaga
    24121 ggaacgtatg ttatatattg ataaacagcc gttattcctg acttatagag agtacgaaat
    24181 tttagaatta ctgtcacgtc atctgtataa agttttcaca aaagaagaga tatatgaaca
    24241 agtatatagc gatgaagctt cagcattgtt tcattctatt tcagaatata tctatcagat
    24301 tagaatgaaa ttttcaagtt ttggaattaa tccaataaaa actattcgcg ggattggtta
    24361 taaatgggat gtttaaaaaa tattcaataa aaaatcgtgt ttggcgcgcc gtcgttgaaa
    24421 ttgtctttgg agtttgtatc actgttttaa tgattgcgat aatatcgctt tctttttcaa
    24481 agttaaatat agtgacatct cataatgtgg gagaagaatt ttatattaaa gataaacagt
    24541 caatcaaaca gttgaacaat tatatgaaga cattggga
//
LOCUS       DAUDWO010000029        22223 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.029, whole genome shotgun sequence.
ACCESSION   DAUDWO010000029 DAUDWO010000000
VERSION     DAUDWO010000029.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 22223)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22223)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22223
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.029"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            117..1109
                     /locus_tag="VHC05_001202"
     CDS             117..1109
                     /locus_tag="VHC05_001202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HEQ5402510.1"
                     /translation="MQDYYTPKGKQLTIHERRQIQRWKLEGRSNREIARLISKAPQTI
                     HNEIKRGLVRQQVRKGKFEAVYSAQHAQLVYQENRKRSVRPIRQRKQDREAIEHYMRQ
                     NYSPEMIVKAKGVQVPVSTIYYWIHHGKLSLGKEAMLYPRKAKQARKHASPYFKPAGK
                     SIEQRPDSINQRLEAGHYEIDTVIMTRAKNQCLLTLTDRKTRHQLIRLIPDKSAQAVN
                     EALTGILKDYTVNSITTDNRTEFSRLSDVFPASAIYYAHPYASWERGTNENHNRLILR
                     WLPKGTKTTTPKEVAAIEHWINHYPKRLFNYKSPVEMLKLANFNLKFGILLETA"
     gene            complement(1615..2001)
                     /gene="rplQ"
                     /locus_tag="VHC05_001203"
     CDS             complement(1615..2001)
                     /gene="rplQ"
                     /locus_tag="VHC05_001203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L17"
                     /protein_id="HEQ5402511.1"
                     /translation="MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTV
                     EKMITLGKRGDLHARRQAAAYVRNEIASENYDEATDKYTSTTALQKLFSEIAPRYAER
                     NGGYTRILKTEPRRGDAAPMAIIELV"
     gene            complement(2016..2954)
                     /locus_tag="VHC05_001204"
     CDS             complement(2016..2954)
                     /locus_tag="VHC05_001204"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="HEQ5402512.1"
                     /translation="MIEFEKPIITKIDENKDYGRFVIEPLERGYGTTLGNSLRRVLLS
                     SLPGAAVTSIKIDGVLHEFDTIPGVREDVMQIILNVKGLAVKSYVEDEKIIELEVEGP
                     AEVTAGDILTDSDIELVNPDHYLFTIAEGHSLRATMTVAKKRGYVPAEGNKKDDAPVG
                     TLAVDSIYTPVKKVNYQVEPARVGSNDGFDKLTIEIMTNGTIIPEDALGLSARVLIEH
                     LNLFTDLTEVAKATEVMKETEKVNDEKVLDRTIEELDLSVRSYNCLKRAGINTVFDLT
                     EKSEPEMMKVRNLGRKSLEEVKVKLADLGLGLKNDK"
     gene            complement(3000..3383)
                     /gene="rpsK"
                     /locus_tag="VHC05_001205"
     CDS             complement(3000..3383)
                     /gene="rpsK"
                     /locus_tag="VHC05_001205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S11"
                     /protein_id="HEQ5402513.1"
                     /translation="MAKPTRKRRVKKNIESGVAHIHATFNNTIVMITDVHGNALAWSS
                     AGALGFKGSRKSTPFAAQMAAEAAAKSAQEHGLKTVEVTVKGPGSGRESAIRALAAAG
                     LEVTAIRDVTPVPHNGARPPKRRRV"
     gene            complement(3401..3766)
                     /gene="rpsM"
                     /locus_tag="VHC05_001206"
     CDS             complement(3401..3766)
                     /gene="rpsM"
                     /locus_tag="VHC05_001206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S13"
                     /protein_id="HEQ5402514.1"
                     /translation="MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDIR
                     VKDLTSDQEDAIRREVDAIKVEGDLRREVNMNIKRLMEIGSYRGIRHRRGLPVRGQNT
                     KNNARTRKGKAVAIAGKKK"
     gene            complement(3784..3900)
                     /gene="rpmJ"
                     /locus_tag="VHC05_001207"
     CDS             complement(3784..3900)
                     /gene="rpmJ"
                     /locus_tag="VHC05_001207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013773089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L36"
                     /protein_id="HEQ5402515.1"
                     /translation="MKVRPSVKPICEYCKVIRRNGRVMVICPTNPKHKQRQG"
     gene            complement(3926..4144)
                     /gene="infA"
                     /locus_tag="VHC05_001208"
     CDS             complement(3926..4144)
                     /gene="infA"
                     /locus_tag="VHC05_001208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-1"
                     /protein_id="HEQ5402516.1"
                     /translation="MAKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNY
                     IRILVGDRVTVEMSPYDLTRGRITYRFK"
     gene            complement(4262..4900)
                     /locus_tag="VHC05_001209"
     CDS             complement(4262..4900)
                     /locus_tag="VHC05_001209"
                     /EC_number="2.7.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylate kinase"
                     /protein_id="HEQ5402517.1"
                     /translation="MNLLIMGLPGAGKGTQAAKIVEEFGVAHISTGDMFRAAMANQTE
                     MGRLAKSYIDKGELVPDEVTNGIVKERLAEDDIAEKGFLLDGYPRTIEQAHALDATLE
                     ELGLRLDGVINIKVDPSCLVERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDK
                     PETVKRRLDVNMAQGEPILEHYRKLGLVTDIEGNQEITDVFADVEKALLELK"
     gene            complement(5050..6354)
                     /gene="secY"
                     /locus_tag="VHC05_001210"
     CDS             complement(5050..6354)
                     /gene="secY"
                     /locus_tag="VHC05_001210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015631723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecY"
                     /protein_id="HEQ5402518.1"
                     /translation="MFLKILKDALKIKTVRNKIFFTIFIILVFRIGTHITVPGVNAKS
                     LEQLSELPFLNMLNLVSGNAMRNFSVFSMGVSPYITASIVVQLLQMDILPKFVEWGKQ
                     GEVGRRKLNQATRYISLVLAFAQSIGITAGFNTLSNVALVKTPDIKTYLLIGALLTTG
                     SVIVTWLGEQITDKGFGNGVSMIIFAGIISSIPSAIATIREDYFVNVKASDLHSSYLI
                     VGILIIAVLAIVFFTTYVQQAEYKIPIQYTKLMQGAPTSSYLPLKVNPAGVIPVIFAS
                     SITTIPSTIIPFVQNGRDLPWLNRLQEIFNYQTPVGMIVYALLIILFSFFYTFVQVNP
                     EKTAENLQKNSSYIPSVRPGRETEQFMSALLKKLATVGAIFLAFISLAPIAAQQALNL
                     SSSIALGGTSLLILISTGIEGMKQLEGYLLKRKYVGFMNTAE"
     gene            complement(6371..6811)
                     /gene="rplO"
                     /locus_tag="VHC05_001211"
     CDS             complement(6371..6811)
                     /gene="rplO"
                     /locus_tag="VHC05_001211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004225266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L15"
                     /protein_id="HEQ5402519.1"
                     /translation="MKLHELKAAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGG
                     GVRLGFEGGQTPLFRRIPKRGFTNINTKEYALVNLDQLNVFDDGTEVTPAILKDAGIV
                     RAEKSGVKVLGNGELTKKLTVKAAKFSKSAEAAIIAKGGSIEVI"
     gene            complement(7027..7209)
                     /gene="rpmD"
                     /locus_tag="VHC05_001212"
     CDS             complement(7027..7209)
                     /gene="rpmD"
                     /locus_tag="VHC05_001212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002959367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L30"
                     /protein_id="HEQ5402520.1"
                     /translation="MAQIKITLTKSPIGRKPEQRKTVVALGLGKLNSSVVKEDNAAIR
                     GMVTAISHLVTVEDVK"
     gene            complement(7224..7718)
                     /gene="rpsE"
                     /locus_tag="VHC05_001213"
     CDS             complement(7224..7718)
                     /gene="rpsE"
                     /locus_tag="VHC05_001213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S5"
                     /protein_id="HEQ5402521.1"
                     /translation="MAFKDNAVELEERVVAINRVTKVVKGGRRLRFAALVVVGDGNGR
                     VGFGTGKAQEVPEAIRKAVEAAKKNMIEVPMVGTTIPHEVYTNFGGAKVLLKPAVEGS
                     GVAAGGAVRAVIELAGVADITSKSLGSNTPINIVRATVEGLKQLKRAEEVAALRGISV
                     SDLA"
     gene            complement(7737..8093)
                     /gene="rplR"
                     /locus_tag="VHC05_001214"
     CDS             complement(7737..8093)
                     /gene="rplR"
                     /locus_tag="VHC05_001214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L18"
                     /protein_id="HEQ5402522.1"
                     /translation="MISKPDKNKIRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQV
                     IDDVAGVTLASASTLDKDVSKGTKTEQAVVVGKLVAERAVAKGISEVVFDRGGYLYHG
                     RVKALADAARENGLKF"
     gene            complement(8198..8734)
                     /gene="rplF"
                     /locus_tag="VHC05_001215"
     CDS             complement(8198..8734)
                     /gene="rplF"
                     /locus_tag="VHC05_001215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L6"
                     /protein_id="HEQ5402523.1"
                     /translation="MSRIGNKVITMPAGVELTNNNNVITVKGPKGELTREFNKNIEIK
                     VEGTEITVVRPNDSKEMKTIHGTTRANLNNMVVGVSEGFKKDLEMKGVGYRAQLQGTK
                     LVLSVGKSHQDEVEAPEGITFTVANPTSISVEGINKEVVGQTAAYIRSLRSPEPYKGK
                     GIRYVGEYVRLKEGKTGK"
     gene            complement(8937..9335)
                     /gene="rpsH"
                     /locus_tag="VHC05_001216"
     CDS             complement(8937..9335)
                     /gene="rpsH"
                     /locus_tag="VHC05_001216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009754342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S8"
                     /protein_id="HEQ5402524.1"
                     /translation="MVMTDPIADFLTRIRNANQVKHEVLEVPASNIKKGIAEILKREG
                     FVKNVEVIEDDKQGIIRVFLKYGKNGERVITNLKRISKPGLRVYAKRDDMPKVLNGLG
                     IAIISTSEGLLTDKEARQKNVGGEVIAYVW"
     gene            complement(9486..9671)
                     /locus_tag="VHC05_001217"
     CDS             complement(9486..9671)
                     /locus_tag="VHC05_001217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011245027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type Z 30S ribosomal protein S14"
                     /protein_id="HEQ5402525.1"
                     /translation="MAKKSMIAKNKRPAKHSTQAYTRCEKCGRPHSVYRKFKLCRVCF
                     RELAYKGQIPGVVKASW"
     gene            complement(9687..10229)
                     /gene="rplE"
                     /locus_tag="VHC05_001218"
     CDS             complement(9687..10229)
                     /gene="rplE"
                     /locus_tag="VHC05_001218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HEQ5402526.1"
                     /translation="MANRLKEKYTNEVIPALTEKFNYTSVMAVPKVEKIVLNMGVGDA
                     VSNAKNLEKAAAELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLD
                     KLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEISFDDVDKVRGLDIVIVTT
                     ANTDEESRELLKGLGMPFAK"
     gene            complement(10253..10558)
                     /gene="rplX"
                     /locus_tag="VHC05_001219"
     CDS             complement(10253..10558)
                     /gene="rplX"
                     /locus_tag="VHC05_001219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011921687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L24"
                     /protein_id="HEQ5402527.1"
                     /translation="MFVKKGDKVRVIAGKDKGTEAVVLKALPKVNKVIVEGVGMIKKH
                     QKPNTENPQGAIVEKEAPIHVSNVQVLDKNGVAGRVGYKVVDGKKVRYSKKSGEVLD"
     gene            complement(10637..11005)
                     /gene="rplN"
                     /locus_tag="VHC05_001220"
     CDS             complement(10637..11005)
                     /gene="rplN"
                     /locus_tag="VHC05_001220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012727667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L14"
                     /protein_id="HEQ5402528.1"
                     /translation="MIQQETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVK
                     QATPGGAVKKGDVVKAVIVRTKTGARRPDGSYIKFDDNAAVIIRDDKTPRGTRIFGPV
                     ARELREGGYMKIVSLAPEVL"
     gene            complement(11030..11290)
                     /gene="rpsQ"
                     /locus_tag="VHC05_001221"
     CDS             complement(11030..11290)
                     /gene="rpsQ"
                     /locus_tag="VHC05_001221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S17"
                     /protein_id="HEQ5402529.1"
                     /translation="MERNQRKTLYGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKK
                     YKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEKAVII"
     gene            complement(11316..11522)
                     /locus_tag="VHC05_001222"
     CDS             complement(11316..11522)
                     /locus_tag="VHC05_001222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006739716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L29"
                     /protein_id="HEQ5402530.1"
                     /translation="MKLQEIKDFVKELRGLSQEELAKKENELKKELFDLRFQAAAGQL
                     EKTARLDEVKKQIARVKTVQSEMK"
     gene            complement(11532..11945)
                     /gene="rplP"
                     /locus_tag="VHC05_001223"
     CDS             complement(11532..11945)
                     /gene="rplP"
                     /locus_tag="VHC05_001223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003029477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L16"
                     /protein_id="HEQ5402531.1"
                     /translation="MLVPKRVKHRREFRGKMRGEAKGGKEVSFGEYGLQATTSHWITN
                     RQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKV
                     MFEIAGVSEEIAREALRLASHKLPVKCKFVKREAE"
     gene            complement(11949..12602)
                     /gene="rpsC"
                     /locus_tag="VHC05_001224"
     CDS             complement(11949..12602)
                     /gene="rpsC"
                     /locus_tag="VHC05_001224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000529931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S3"
                     /protein_id="HEQ5402532.1"
                     /translation="MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFINK
                     ELADASVSTIEIERAVNKVIVSLHTAKPGMVIGKGGANVDALRGQLNKLTGKQVHINI
                     IEIKQPDLDAHLVGENIARQLEQRVAFRRAQKQAIQRTMRAGAKGIKTQVSGRLNGAD
                     IARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK"
     gene            complement(12615..12959)
                     /gene="rplV"
                     /locus_tag="VHC05_001225"
     CDS             complement(12615..12959)
                     /gene="rplV"
                     /locus_tag="VHC05_001225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L22"
                     /protein_id="HEQ5402533.1"
                     /translation="MAEITSAKAMARTVRVSPRKTRLVLDLIRGKKVADAIAILKFTP
                     NKAARVIEKTLNSAIANAENNFGLEKANLVVSETFANEGPTMKRFRPRAKGSASPINK
                     RTTHVTVVVSEK"
     gene            complement(12975..13253)
                     /gene="rpsS"
                     /locus_tag="VHC05_001226"
     CDS             complement(12975..13253)
                     /gene="rpsS"
                     /locus_tag="VHC05_001226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000533765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S19"
                     /protein_id="HEQ5402534.1"
                     /translation="MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSF
                     IGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRR"
     gene            complement(13392..14225)
                     /gene="rplB"
                     /locus_tag="VHC05_001227"
     CDS             complement(13392..14225)
                     /gene="rplB"
                     /locus_tag="VHC05_001227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019790357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L2"
                     /protein_id="HEQ5402535.1"
                     /translation="MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVSLKSKAGRN
                     NNGRITVRHQGGGHKRHYRLIDFKRNKDGVEAVVKTIEYDPNRTANIALVHYTDGVKA
                     YIIAPKGLEVGQRIVSGPDADIKVGNALPLANIPVGTVVHNIELKPGKGGELVRAAGA
                     SAQVLGQEGKYVLVRLQSGEVRMILGTCRATIGTVGNEQQSLVNIGKAGRSRWKGVRP
                     TVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNE
                     K"
     gene            complement(14243..14539)
                     /locus_tag="VHC05_001228"
     CDS             complement(14243..14539)
                     /locus_tag="VHC05_001228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006739217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L23"
                     /protein_id="HEQ5402536.1"
                     /translation="MNLYDVIKKPVITEKSMIALEAGKYTFEVDTRAHKLLIKQAVEA
                     AFDGVKVASVNTVNVKPKAKRVGRYTGFTSKTKKAIITLTADSKAIELFAAEAE"
     gene            complement(14539..15162)
                     /gene="rplD"
                     /locus_tag="VHC05_001229"
     CDS             complement(14539..15162)
                     /gene="rplD"
                     /locus_tag="VHC05_001229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L4"
                     /protein_id="HEQ5402537.1"
                     /translation="MANVNLFDQTGKEVSSVELNDAIFGIEPNESVVFDVVISQRASL
                     RQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLP
                     QKVRRLALKSVYSAKVAEDKFVAVEGLSFAAPKTAEFAKVLSALSIDTKVLVLVEEGN
                     EFAALSARNLPNVTVATAATASVLDIVNADKLLVTKEAISTIEEVLA"
     gene            complement(15186..15812)
                     /gene="rplC"
                     /locus_tag="VHC05_001230"
     CDS             complement(15186..15812)
                     /gene="rplC"
                     /locus_tag="VHC05_001230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L3"
                     /protein_id="HEQ5402538.1"
                     /translation="MTKGILGKKVGMTQIFTESGEFIPVTVIEATPNVVLQVKTVETD
                     GYEAVQVGFDDKREVLSNKPAKGHVAKANTAPKRFIREFKNIEGLEVGAELSVEQFEA
                     GDVVDVTGTSKGKGFQGVIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKNKRLAG
                     RMGGNRVTVQNLEIVQVIPEKNVILVKGNVPGAKKSLITIKSAVKAAK"
     gene            complement(16060..16368)
                     /gene="rpsJ"
                     /locus_tag="VHC05_001231"
     CDS             complement(16060..16368)
                     /gene="rpsJ"
                     /locus_tag="VHC05_001231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S10"
                     /protein_id="HEQ5402539.1"
                     /translation="MANKKIRIRLKAYEHRTLDTAAEKIVETATRTGATVAGPVPLPT
                     ERSLYTIIRATHKYKDSREQFEMRTHKRLVDIINPTQKTVDALMKLDLPSGVNVEIKL
                     "
     gene            complement(16568..17857)
                     /locus_tag="VHC05_001232"
     CDS             complement(16568..17857)
                     /locus_tag="VHC05_001232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HEQ5402540.1"
                     /translation="MIYNRRKIFSLALPSMIENILQMLMGMVDNYLVAQIGLVAVSGV
                     SIANNIISIYQSLFIALGAAVSSLIARSIGENNQNKQLNYMAGVLQVTLLLSVGLGLL
                     SVVGHHQVLEWLGAEASVTLVGGQYLSIVGGMIVSLGLLTSLGAIVRAQGYPKIPMQV
                     SLLINVLNAIFSALSIYVWGFSLLGVAWATVLSRLVGVFLLCQFIPIKQVAKRLMRPL
                     DKIIFDLSLPAAGERLMMRAGDVLIIGIVVRFGTTALAGNAIGETLTQFNYMPGLAMA
                     TATIILVARQLGGGKVTEIRYIIREAFILSTLMMLVMGALTYLLGPSLLPLFTQNTDA
                     QRSAMVVLLFSLLGAPATAGTLVYTAVWQGLGKAKLPFYATTIGMWVIRIGLGYVIGV
                     VWQYGLIGVWMATVLDNTSRWFILSKQFKKYQEITFH"
     gene            complement(18245..19261)
                     /gene="adhP"
                     /locus_tag="VHC05_001233"
     CDS             complement(18245..19261)
                     /gene="adhP"
                     /locus_tag="VHC05_001233"
                     /EC_number="1.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase AdhP"
                     /protein_id="HEQ5402541.1"
                     /translation="MKAVVVNQASTGVEVVEHDLPNVGHGEALVKVEYCGVCHTDLHV
                     AHGDFGQVPGRILGHEGIGIVEEIGEGVTSLKVGDRVSIAWFFEGCGHCEYCTTGRET
                     LCRSVKNAGYSVDGGMSEYAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGA
                     APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIE
                     DVPGYIQEKTGGAHGVVVTAVSKVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVL
                     DGIKVVGSLVGTRKDLEEAFAFGAEGLVVPVVEKVPVDTAPGVFDEMERGLIQGRKVL
                     DFIS"
     gene            complement(19513..22155)
                     /gene="adhE"
                     /locus_tag="VHC05_001234"
                     /gene_synonym="adhC"
     CDS             complement(19513..22155)
                     /gene="adhE"
                     /locus_tag="VHC05_001234"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HEQ5402542.1"
                     /translation="MTEGHNTVETTSVSVTIDALVQKGLAALEEMRKLDQEQVDYIVA
                     KASVAALDAHGELAKHAYEETGRGVFEDKATKNLFACEHVVNNMRHQKTVGIIEEDDV
                     TGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARI
                     VRDAAIAAGAPENCVQWVETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPAL
                     GVGAGNVPAYVEKSANIRQAAHDIVMSKSFDNGMVCASEQAVIIDKEIYDDFVAEFKS
                     YHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPATWIAAQAGFTVPEGTN
                     ILAAECTEVSEKEPLTREKLSPVIAVLKSESREDGVEKARQMVEFNGLGHSAAIHTAD
                     AELAKEFGTRIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNAVGDNVSAIN
                     LLNIKKVGRRRNNMQWFKVPSKTYFERDSIQYLQKCRDVERVMIVTDHAMVELGFLDR
                     IIEQLDLRRNKVVYQIFAEVEPDPDITTVMKGTELMRTFKPDTIIALGGGSPMDAAKV
                     MWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAISTTSGTGSEVTPFAVIS
                     DKANNRKYPIADYSLTPTVAIVDPALVLTVPGFIAADTGMDVLTHATEAYVSQMANDF
                     TDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMAGMAFANAFLGISHSMAHKIG
                     AQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLPASTP
                     EEAVESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELAYLAYEDQCSPANPRLP
                     MVDHMQEIIEDAYYGYAERPGRRK"
BASE COUNT         6462 a         4720 c         4026 g         7015 t
ORIGIN      
        1 aattttgttg gaaacgaaaa attctaaaat gaacttagcc actttttagg tatgaaaaaa
       61 gcacctcata agaggtatac ttgtagttca ccacaaacac aaggaaactc aaaaagatgc
      121 aagattatta tacaccaaaa ggcaaacaat tgacaatcca tgagcgtcgg caaattcaac
      181 gctggaagct ggaaggtcgc tctaatcgtg aaattgctcg cttaataagt aaggcccccc
      241 agaccattca taatgaaatc aagcgaggct tggttaggca acaggttcgt aaaggaaagt
      301 ttgaagccgt ttattctgct caacatgctc agttggtcta tcaagaaaat cgcaagcgtt
      361 ctgttagacc cattagacag cgtaagcaag atagggaggc tattgaacac tacatgcgtc
      421 agaactattc ccctgagatg atagttaaag ctaagggagt tcaagtccct gtatctacca
      481 tctattactg gattcatcat gggaaattaa gtcttggtaa ggaggctatg ctttatccga
      541 gaaaggctaa gcaggctaga aaacatgcca gtccttattt taaacccgca ggaaagagta
      601 ttgaacaacg gccagatagc attaaccagc gtcttgaagc tgggcattat gagattgata
      661 cagtcattat gacgagggct aaaaatcaat gcttactcac cctaacagac aggaaaacac
      721 gtcatcagct gattcgatta ataccggata agtctgctca agccgtcaat gaagctctta
      781 cggggattct aaaagactac accgtcaact ctatcacgac agacaacagg acagaatttt
      841 ctcgcttatc agatgtcttt ccagcaagtg ccatctacta tgcccatccc tatgcgtcat
      901 gggagagagg cactaacgaa aaccataatc gccttattct cagatggctc cctaaaggta
      961 ccaaaacaac aacccctaaa gaagtcgctg ctattgaaca ttggatcaat cattatccta
     1021 aacgactctt caactacaag tcgccagtag aaatgttaaa actggctaac ttcaacttga
     1081 aatttggcat tttgttggaa acggcttaaa gtgacagatt ttaaaagtaa aaaagatatt
     1141 ttcacctcca aattaaaaga ggattttaaa atacttatta ataaaatatt gaatagggga
     1201 taaaactaac aatatagttt gagcatctgt ttgcgatgca agtatttttt cggacattta
     1261 aatgagagga ttacatcgtt tatttgccca tgagaggtct ttaaacacct gcataaggtt
     1321 ttcttactct aatgacctta ttgtctctga gaaaacttta taaacgcatc agaagaggct
     1381 tctgtgttat tgttttgctc agcttaaaag cggggggtgt tcacctcata atacaacaaa
     1441 acgcctgctt ataaaaagtt tctatagctc agataccttt cataaacaag cgttacatat
     1501 taacaatatg atgagtgttc ccgctaggaa aaatcctagc ggtagaccag agctagacta
     1561 agaataatct ctcgattact ccatcatcat aacactcaac aaaattgata aaaattaaac
     1621 taattcaata attgccattg gagcagcatc tccacggcgt ggttctgttt taagaatacg
     1681 agtgtatcca ccattacgtt ctgcataacg aggtgcaatt tctgagaaaa gtttttgaag
     1741 agctgtcgtt gatgtgtatt tatcggtagc ttcatcataa ttttctgatg cgatttcgtt
     1801 acgaacgtat gcagctgctt ggcgacgagc atgaagatca ccacgtttac caagagtaat
     1861 cattttttca actgttttac ggatttcttt tgcacgtgct tctgtcgtta caattgattc
     1921 gttgatcaaa agatctgtcg tcaaatcacg aagcattgct ttacgttgtg agctagtgcg
     1981 tcctagttta cggtaagcca ttttgtcctc ctatattatt tatcgttttt tagtccgaga
     2041 cctaagtcag caagtttaac cttaacttct tcaaggctct tacgtccaag attacggact
     2101 ttcatcattt caggctcaga tttttctgtt aagtcgaaga cagtgttaat gcctgcacgt
     2161 tttaaacagt tatatgagcg tacggataaa tcaagctcct ctatggtgcg gtcaagtacc
     2221 ttttcatcgt tcactttttc agtttctttc attacttcgg tagcttttgc aacctctgtt
     2281 aaatcagtaa acaggtttaa gtgttcgatc aaaactcgag cagatagacc taaagcatct
     2341 tcaggaataa ttgttccgtt tgtcatgatt tcaatcgtta atttatcaaa gccatcattg
     2401 ctacctacac gggcaggctc aacttgataa ttaacttttt taactggcgt atagattgaa
     2461 tctactgcca atgtacccac aggtgcatca tcttttttgt ttccttctgc tggcacataa
     2521 ccacgttttt tagcaacagt cattgttgca cgtagagaat gtccttcagc gattgtaaaa
     2581 agataatgat ccgggttaac aagttcgata tcactgtcag taagaatatc accagctgtt
     2641 acctctgctg gtccttctac ttcaagttcg ataatctttt cgtcttcgac gtatgatttc
     2701 acagcaagtc ccttaacatt aaggataatt tgcatgacat cttcacgtac acctgggatt
     2761 gtatcaaatt cgtgtagtac tccatcaatt ttaattgatg ttactgctgc acctggaagt
     2821 gaagacaaga gtacacgacg aagagaatta cctagagttg ttccgtagcc acgttcaagt
     2881 ggttcgatga caaatctacc gtaatcttta ttttcatcaa tttttgttat tattggtttt
     2941 tcaaactcaa tcattttttc acccctcgaa acgaaacttg tgtactattt gttatatgat
     3001 tatacacgac gacgttttgg aggacgagca ccattatgtg gcacaggggt cacatcacga
     3061 attgcagtta cttcaagacc tgcagctgct agagcacgaa tagctgattc acgacctgaa
     3121 ccaggacctt ttacagtcac ttcaacagtt tttagtccgt gttcttgtgc agattttgca
     3181 gcagcttctg cagccatttg agcagcaaat ggagtagatt tacgagaacc tttgaaacca
     3241 agagcaccag ctgatgacca tgcaagagca ttaccatgca catctgtaat cataacaata
     3301 gtgttattaa atgtagcgtg aatgtgtgca acaccagatt cgatgttctt tttcacacga
     3361 cgtttacgtg ttggtttagc caattgtttt acctcctatt ttattttttc ttacctgcaa
     3421 tcgcaacagc tttcccttta cgagtgcgag cattgttttt agtattttgt ccacggacag
     3481 gaagtccacg acgatgacgg attccacggt atgaaccgat ttccatcaaa cgtttaatgt
     3541 tcatgtttac ttcacgtcga aggtcacctt caactttgat tgcatccact tcacgacgga
     3601 tagcatcttc ttgatctgat gttaaatctt taacacggat atcttcagaa atacctgcag
     3661 ctgctaagat ttttttagat gttgcaagac caattccgta aacataagta agtgaaatta
     3721 ctacgcgttt atcatttggg atatcaactc cagcaatacg agccattttt tctcctttct
     3781 attttatcct tgacgttgtt tgtgttttgg atttgtcgga caaattacca taacacgacc
     3841 attacggcga ataactttac agtattcgca aattggttta accgatggtc ttaccttcat
     3901 gttttaatcc ctccaattat ttcgattatt taaagcggta tgtgatgcgt ccacgtgtca
     3961 agtcataagg actcatttct actgtaacac ggtcacctac taaaatacga atgtaatttt
     4021 tgcggatttt tcctgataca gttgctagaa tttgatgtcc attttccaat tcaacagtaa
     4081 acattgcatt tggcatcgtt tctactactt tgccttcaat ttcaatcacg tcttcttttg
     4141 ccacgcaaaa gtacccccta aatttcgatt tgatgtcctc tgagcacaga ggtaacaatt
     4201 ataagtcaga ctaaactagt atatcattac taatctactt atgcaagtag attagtataa
     4261 tttatttgag ttctagcaac gctttttcaa catctgcaaa aacgtctgtt atttcttgat
     4321 taccttcaat atctgtaaca agaccaagct tacgatagtg ttcaagaata ggttctcctt
     4381 gagccatatt gacgtccaaa cgacgtttaa cagtttcagg cttatcatct tctcgttgat
     4441 agtaatcttc ttctttataa tctactggtg ggttgaacac tttatggaac gtttcaccag
     4501 ttttacgatt gataatacga ccactcaaac gctctacaag acatgatgga tccactttaa
     4561 tattaataac accatctaag cggagtccta gttcttcaag tgttgcatct aaggcgtgtg
     4621 cttgttcaat agtacgtgga tacccatcaa gcaaaaaacc tttttctgcg atatcatcct
     4681 cagctaagcg ctcttttaca atcccgtttg tgacttcatc aggaaccaat tcacctttat
     4741 caatataact tttagctaaa cgtcccattt cggtttgatt agccattgcg gcgcggaaca
     4801 tatcccctgt tgagatgtga gcaacaccaa attcttcaac aatcttagct gcttgggtcc
     4861 ctttaccagc tcccggcaaa cccatgatta aaagattcat cttttcctcc tcttttaaaa
     4921 taaatacata gtaggaaatt attttccttg gtttttgttt tcaaatggca acaagaaatc
     4981 gtttgatgat aaccaagtct tattgtcatt taaaaacaaa atagaaggtt gacaatgtca
     5041 acctgtattc tattctgctg tattcataaa tccgacatat tttctcttta gaagatatcc
     5101 ctcaagctgt ttcatacctt cgataccagt tgaaatcaaa atgagcaaac tagttccacc
     5161 taaagcaata ctagaagaaa ggttgagagc ttgttgtgct gctattggcg ctaaagagat
     5221 aaatgctaag aagatagctc ctacggttgc tagttttttt agcaatgcgg acataaattg
     5281 ttctgtctca cgtccagggc gaacacttgg tatatatgag gaattcttct gaagattttc
     5341 tgctgtcttc tcaggattaa cttgtacaaa ggtatagaag aatgagaaca atataatcaa
     5401 caaggcgtaa actatcattc cgactggagt ttgataatta aaaatttctt gcaaacggtt
     5461 taaccacggt aaatctctac cattttgaac aaaaggaata atcgtacttg ggatagttgt
     5521 aatcgagcta gcaaagataa cgggaataac gccggctgga tttactttta atggaagata
     5581 tgaacttgta ggtgcacctt gcattagctt tgtgtattgg attggaattt tatattccgc
     5641 ttgttggaca tatgttgtaa agaaaacaat agcaagaaca gctatgatta aaatcccaac
     5701 aatgagataa gacgagtgta aatcacttgc cttaacattt acaaaatagt cttcacgaat
     5761 tgttgcaatt gcacttggaa tagacgaaat aatacccgca aagataatca ttgatacgcc
     5821 attaccaaat cctttatctg tgatttgttc tccaagccag gtaacaataa cgctacctgt
     5881 tgtcagtaat gccccgatca gtaaatatgt tttgatgtct ggtgtcttaa caagtgcaac
     5941 gttcgacaaa gtattaaacc ctgcagtgat accaatggat tgggcaaaag ccaaaacaag
     6001 tgaaatatag cgcgtcgctt gatttaattt acgacgtcca acctcacctt gtttgcccca
     6061 ctcaacaaac ttaggtaaaa tatccatctg caataactga acaacgatag aagcagtaat
     6121 atatgggcta acccccattg aaaatactga gaaatttctc atcgcattac cactaactaa
     6181 gtttaacata tttaagaaag ggagttcact taattgctct aagctcttgg catttacacc
     6241 aggtacggta atatgtgtcc caattcggaa tacaagaatg ataaatatag taaagaaaat
     6301 tttattccgt acagtcttta tctttaacgc gtcttttagt atttttaaga acataatgag
     6361 tatcccctca ttagatgact tcgattgaac cacctttagc aataatagct gcttcagcag
     6421 attttgagaa cttagctgct tttacagtca attttttagt caattcaccg ttaccaagca
     6481 ctttaacgcc tgatttttca gctcggacaa taccagcatc ttttaaaata gccggagtca
     6541 cttctgtacc atcatcaaaa acattcagtt gatcaagatt cacaagtgca tattctttag
     6601 tattgatatt tgtaaagcca cgttttggaa tacgacggaa caatggtgtt tgtccacctt
     6661 caaaacctaa acgtacaccg ccaccgctac gagctttttg acctttttga ccgcgaccag
     6721 atgttttacc attacctgat gatgtcccac gaccaacacg gttacgtact ttacgtgagc
     6781 cttcagcagc ttttaattca tgaagtttca ttttttctcc ttttttttgt aaaatgctag
     6841 cgcctctatg agggaaaagg actccctata gaaactcgcc tatacattaa tgatacttaa
     6901 gttatccaaa ataacttaat acagatacgc actaaccgac tactgtttgt tgccaaaaaa
     6961 gcaaactaca agagtcggtt ttgtgctcgt ttttaattat gaaatcagag atttcacagt
     7021 tataacttat ttaacatctt caacggtaac caagtgagaa atagctgtca ccataccacg
     7081 gatagcagca ttatcttctt tgactactga agaatttaat ttaccaagtc caagagcaac
     7141 aacagtttta cgttgttctg gcttacgtcc gataggagac ttagtcaaag taattttaat
     7201 ttgagccatg atgatcccct ttcttatgct aagtcagaaa ctgagatgcc acgaagtgcg
     7261 gcaacttctt ctgcacgttt aagttgtttc aatccttcaa cagttgcacg aacaatgttg
     7321 attggagtgt ttgaaccaag agattttgaa gtaatatcag caacacctgc taattcgatg
     7381 acggcacgaa ctgcaccacc agcagcaact ccagaacctt ctacagctgg tttcaataat
     7441 actttagctc caccgaagtt agtgtaaact tcgtgaggga ttgttgtacc aaccattggt
     7501 acttcgatca tgtttttctt agcagcttca actgctttac gaatagcttc tggaacttct
     7561 tgagctttac cagtaccaaa tccaacacga ccatttccat caccaacaac tacaagagct
     7621 gcaaagcgaa gacgacgtcc acctttaaca acttttgtaa cgcggttaat cgcaacaacg
     7681 cgttcttcaa gttcaactgc attatcttta aatgccatta ttttgtgtcc tccctattag
     7741 aatttcaatc cgttttcacg agctgcatca gccaaggctt taacacgtcc gtgatagaga
     7801 tatccaccgc ggtcaaacac cacttcagaa atacctttag ccactgcacg ttcagcaaca
     7861 agtttgccga ctacaacggc ttgttctgtt tttgttcctt tagaaacgtc tttatcaaga
     7921 gttgatgcac ttgcgagcgt tacacccgct acgtcatcaa taacttgagc gtagatgcct
     7981 gtattagaac ggaatacgtt caaacgtggg cgatcagcag ttccagagag tttaccgcgg
     8041 acgcgacggt ggcgtttttg gcggattttg tttttatctg gtttcgaaat cacaattttc
     8101 acctcttaat tttaatcaat ttgtctcatt gacaagttgt cgattgaact tatcgagcat
     8161 gttaaggtgc aatacttccc atacccgact aagaacatta tttacctgtt ttaccttctt
     8221 taaggcgtac gtattcacca acgtaacgga tccctttgcc tttgtaaggc tctggtgaac
     8281 gcaagctacg gatgtaagca gctgtttgac caacaacttc tttgttgatt ccttcaactg
     8341 agattgaagt tgggttagca acagtgaaag taattccttc tggagcttca acttcgtctt
     8401 ggtgagattt acctactgaa aggacaagtt tagtaccttg aagttgagca cggtaaccga
     8461 cacccttcat ttcaagatct tttttgaaac cttcagaaac acctacaacc atgttattca
     8521 agttagcacg ggttgtacca tggattgttt tcatttcttt tgagtcgtta ggacgtacaa
     8581 ctgtgatttc agtcccttca actttgattt caatattttt gttgaactca cgagtgagtt
     8641 cgcctttagg gcctttaaca gtaataacat tgttgttatt tgttaattca acacctgcag
     8701 gcatagtaat tactttatta ccaatacgtg acatgtttgt tttctcctgt taaattgtca
     8761 agccgcatag cgactagttt tcacgggggt ttgatagaat gatatacttc aatttatatt
     8821 tcaaaattga acacgagctg tggtctgtgt gaaaaagata aatcttcctt gagtgtaaac
     8881 acgctacgtc agatttccta ttttcacttt gtccacgacg ctcttagtat cttaaattac
     8941 caaacgtaag cgatcacttc tccaccaaca ttcttttggc gagcttcttt gtcagtcaaa
     9001 agaccttctg atgttgaaat gattgcaatt ccaagtccgt taagaacttt aggcatgtca
     9061 tcacgttttg cgtaaacgcg aagacctggt tttgaaatac gttttaagtt agtgataaca
     9121 cgctcaccat tttttccgta ttttaagaac acacgaatga tgccttgttt atcatcttcg
     9181 ataacttcaa cattttttac aaaaccttca cgtttaagaa tctcagcaat ccctttttta
     9241 atgtttgaag caggtacttc taacacttcg tgttttactt gattagcatt acggatacgt
     9301 gttaaaaagt ctgcaattgg gtcagtcata accatttttt atattctcct cttactagca
     9361 gtttgatgct atcacttact agttaatgtt gtccttaaag gactttggta tcagcttatg
     9421 ctcacaccgt tttaattaag cacaagactt aatctgaaga acaaattaag ttttgtgtca
     9481 tatttttacc aagaagcttt gacaacacct ggaatttgac ctttgtaagc caattcacgg
     9541 aagcaaacac gacaaagttt aaacttgcgg taaactgaat gtggacgtcc acatttttca
     9601 cagcgagtat aagcttgtgt agagtgtttt gcaggacgtt tgttcttagc aatcatagat
     9661 tttttagcca atttatttac cccctattat tttgcaaaag gcattccaag gcccttaagc
     9721 aattcacgtg attcttcgtc agtatttgca gtagtgacga ttacaatatc aagaccacgt
     9781 actttatcaa catcatcaaa gctgatttct gggaagataa gttgttcttt cacaccgaga
     9841 gtgtagtttc cgcgtccatc aaacgatttt gttggaacgc catggaagtc acgtacacga
     9901 ggaagtgaaa cgctaaccaa tttgtctagg aattcgtaca tacgttcgcc acggagggta
     9961 acttttgcac cgatcgctac accttcacga agacggaagc cagcgattga tttcttagct
    10021 ttagtaataa gtggtttttg acctgagata agtgctaatt cagctgcagc tttctctagg
    10081 ttttttgcgt tggatacagc atcaccaaca cccatattga gaacaatttt ctcaactttt
    10141 ggcacagcca taactgatgt gtaattgaat ttctctgtca acgcaggaat tacttcgtta
    10201 gtatattttt cttttaaacg atttgccatt atgcttctcc tttccttcgt gattaatcaa
    10261 gcacttcgcc tgattttttg ctgtaacgta cttttttacc gtcaacaact ttataaccaa
    10321 cacgtccagc tacaccattt ttatctaata cttgaacatt agagacatgg ataggtgctt
    10381 ctttttcgac gatagctcct tgaggatttt cagtgttagg tttttggtgt tttttaatca
    10441 ttccaacacc ttcaacaata actttgttaa cttttggaag tgctttaaga actacagctt
    10501 cagtgccttt gtccttgcca gcaattacgc gaactttgtc gccttttttt acaaacattc
    10561 tggtttctcc tattatttct tacgccccga tgggcaccct aggaaaacct aggggactac
    10621 gtttgttaac ctgagattaa agtacttctg gtgcaagtga tacgatcttc atgtagccac
    10681 cctcacgcaa ttcgcgtgca actgggccaa agatacgagt tccgcgagga gttttatcat
    10741 cacggatgat tacagcagca ttgtcgtcaa atttgatgta tgaaccgtct ggacggcgtg
    10801 caccagtttt tgtacgaacg ataacagctt taaccacatc acctttttta actgctccac
    10861 caggagtagc ttgttttaca gaagcaacga ttacgtcacc gatgttagcg aatttacgtc
    10921 ctgaaccacc aagtactttg atagtcaaga tctcacgagc accgctatta tcagcaactt
    10981 tcaagcgagt ttcttgttga atcatttcaa ttttctcctt ttagtttgat tagataataa
    11041 cagctttttc cactacttcc acaagacgga aacgttttgt agctgaaagt gggcgagttt
    11101 ccatgatacg aacgatatcg ccttctttag caacgttgtt ttcgtcatgt gctttatatt
    11161 ttttagaata gttgatacgt ttaccataga ctgggtggtt acgtttagtt tcaactacaa
    11221 ctgtgattgt tttgtccatc ttgtcagaca ctacgcgtcc gtaaagagtt ttacgttgat
    11281 tacgttccat ttagaatttc tcctttccca atctattatt tcatttctga ttgcacagtt
    11341 ttaacacgtg caatttgttt cttaacttcg tcaaggcgag cagtcttttc aagttgacct
    11401 gctgcagctt ggaaacgaag atcaaacaat tcttttttga gttcgttttc tttcttagca
    11461 agttcttctt gagacaatcc acgaagctct ttaacaaaat ctttaatttc ttgaagtttc
    11521 atgtcttctc cttattctgc ttcacgtttt acgaatttgc acttaactgg taatttgtgg
    11581 ctagcaagac gtaatgcttc gcgagcaatt tcttcagaaa caccagcaat ttcaaacatc
    11641 actttaccac gtttaactgg tgctacccaa ccttcaggtg cccctttacc agaacccata
    11701 cgtacaccga tagcttttgc agtgtatgat ttgtgtggga agattttaat ccaaacttta
    11761 ccaccacgtt tcatgtaacg agtcatcgca atacgggcag cttcgatttg acggtttgta
    11821 atccagtggc tagttgtggc ttgaagtccg tattcaccga atgaaacttc tttaccacct
    11881 ttagcctcac cgcgcatttt tccacggaat tcgcgacggt gtttaacacg tttaggtact
    11941 aacatttgtt atttgcctcc tttagtgttt ttacgagctg gaagaacttc tccacggtaa
    12001 atccaaactt taacgccaag tttaccataa gttgtgtcag cttcttccca agcatagtcg
    12061 atatcagcgc gaagcgtgtg aagtggaaca gttccttctg aataaccttc agcacgagcg
    12121 atatcagcac cgttcaaacg accagaaact tgagttttaa tccctttagc tcctgcacgc
    12181 attgtacgtt ggattgcttg tttttgagca cgacggaaag caacacgttg ctcaagttga
    12241 cgagcaatat tttcaccaac aaggtgagca tctaaatcag gttgtttgat ttcgatgatg
    12301 ttgatgtgta cttgttttcc agttaatttg ttaagttgac cacgaagagc gtcaacattt
    12361 gcgccacctt taccgataac catacctggt ttagcagtgt gaagtgaaac aataactttg
    12421 tttactgcac gttcaatttc aatagttgaa actgatgcgt cagctaattc tttattaatg
    12481 aatttacgga ttgcaagatc ttcatgaagg taatccgcgt attctttttc agcataccat
    12541 ttcgcatccc agtcacggat gattccgaca cgcataccaa ttggatgtac tttttgaccc
    12601 acgattttac ctccttattt ttctgataca actacagtta cgtgagttgt acgtttgttg
    12661 attggtgaag ctgaaccttt cgcacgtgga cggaaacgtt tcattgttgg tccttcgtta
    12721 gcgaatgttt cagatactac caagtttgct ttttccaaac caaagttgtt ttctgcgtta
    12781 gcaattgctg agttaagagt tttctcaata acacgagctg ctttgtttgg agtgaatttt
    12841 aagattgcga ttgcgtcagc aactttctta ccacggataa gatcaagtac taaacgtgtt
    12901 ttacgaggtg aaacacgcac tgtacgagcc attgctttag ctgaagtaat ttctgccatt
    12961 gtgtcctcct cctattaacg acgtgttttc ttgtcgtcag ctgcgtgacc tttgtaagta
    13021 cgtgttggtg caaattcacc aagtttgtga cctaccatgt cttcttggat gtaaacaggt
    13081 acatgtttac gtccgtcata aactgcgatt gtatatccga tgaaacttgg gaaaatcgtt
    13141 gaacgacgtg accaagtttt gattactttt ttcttttcgt cgtttgcttg agcttcaact
    13201 tttttcatca aatgctcatc gacgaaaggt ccttttttaa gactacgtcc cattttgtag
    13261 ttttctcctt taaaaaatgt accacagcgg cttgagttca agagcaagac tccaaactct
    13321 accgagttgg cggaataaat agcaaagcta ttgtaacgct atttcagcaa gttttaagca
    13381 acttactaag attatttttc gttacgacga cgaacgataa gtttgtctga tttagctttc
    13441 ttgttacgag ttttaagacc aagcgctggt ttaccccatg gagttgatgg cgctttacgt
    13501 ccaactggtg ctttaccttc accaccaccg tgtgggtgat cgttagggtt cattacagaa
    13561 ccacgaactg ttgggcggac acctttccaa cggctacgtc ctgctttacc aatgttaaca
    13621 agtgattgtt gttcgttacc aacagtaccg atagttgcac ggcatgtacc aagaatcata
    13681 cgaacttcgc ctgattgaag acgaacaaga acgtatttac cttcttgacc aagtacttga
    13741 gcagaagctc cagctgcacg aacaagttct ccacctttac caggtttcaa ctcaatattg
    13801 tgaacaactg taccgacagg aatgtttgct aatggaagtg cgttaccaac tttgatatct
    13861 gcatctggac cagaaacaat acgttgacct acttcaagac ctttaggtgc aatgatgtaa
    13921 gctttcacac cgtcagtgta atgtacaagt gcgatgtttg cagtacggtt tggatcgtat
    13981 tcgattgttt taacaactgc ttcaacgcca tctttgttac gtttgaagtc gatcaaacgg
    14041 taatgacgtt tgtgtccacc accttggtga cgaactgtga tgcgaccatt gttgttacga
    14101 ccagctttgc tcttaagaga aacaagcaat gatttctcag gcgtgcttgt tgtgatttcc
    14161 gcgaaatcca aagaagtcat gttacgacgg ccatttgtcg ttggtttata aactttaata
    14221 cccacgttat ttcctcctta gattattcag cttcagctgc gaacaactcg attgctttag
    14281 aatcagctgt aagagtgatg atagcttttt tagtttttga agtgaaacct gtgtaacgac
    14341 caacgcgttt tgcttttggt ttaacgttaa cagtgtttac acttgcaact ttaactccgt
    14401 caaaagcagc ttcaacagct tgtttgatca aaagtttgtg tgcacgagta tcaacttcga
    14461 aagtgtattt gcctgcttca agagcaatca ttgacttctc agtgataact ggttttttga
    14521 ttacgtcgta caaattcatt atgcaagaac ctcctcaatt gtagagattg cttctttagt
    14581 aacaagaagt ttgtctgcgt tcacgatatc aagaacactt gcagttgctg cagttgcaac
    14641 agttacgttt ggaaggttac gtgcagaaag tgctgcaaat tcatttcctt cttcaacaag
    14701 aacaagtact tttgtatcaa tgctaagagc tgaaagcact tttgcaaatt cagcagtttt
    14761 tggtgctgca aatgaaaggc cttctacagc tacaaattta tcttcagcaa cttttgctga
    14821 gtaaactgat ttcaacgcaa ggcgacgaac tttttgtgga agtttgtatc cgtatgaacg
    14881 gggagttggt ccaaagacaa caccaccacc acgccattgt ggtgagcgga tagaaccttg
    14941 acgagcgcgt ccagttcctt tttgacgcca tggtttacgt ccaccacctg atactgctga
    15001 acggttttta accgcatgag taccttggcg aaggctagcg cgttggctaa ttacaacatc
    15061 aaaaacaact gattcgtttg gttcgatacc gaagatagcg tcgtttaatt caactgagct
    15121 aacttcttta ccagtttggt caaatagatt tacgtttgcc attttaactg ttttctcctt
    15181 tcttattatt tagcagcttt aactgctgac ttgatagtga taagagattt cttagcacct
    15241 ggtacgttac ctttaacaag gataacgttc ttttctggga taacttgtac aatttcaagg
    15301 ttttgaactg ttacacggtt accacccata cgtcctgcca agcgtttgtt tttgaaaaca
    15361 cggttaggcg caacaggtcc catagaacct gggcgacgat ggtaacgaga accgtgagcc
    15421 ataggaccac gtgattgacc atggcgtttg ataacacctt ggaaaccttt accttttgat
    15481 gtccctgtga cgtcaacaac atcaccagct tcaaattgtt ctacagataa ttctgcacca
    15541 acttctaagc cttcaatgtt tttgaattca cgaatgaagc gcttaggagc tgtgtttgct
    15601 tttgcaacat ggcctttggc aggtttgtta ctcaagactt cacgtttgtc atcaaaacca
    15661 acctgaactg cttcgtaacc gtctgtttca acagttttaa cttgaagcac aacgtttgga
    15721 gttgcttcaa tgacagtaac agggatgaat tcgcctgatt cagtgaagat ttgagtcatt
    15781 cccacttttt tccctaagat tccttttgtc atgagaaaat atttcctttt cttaataata
    15841 tttcaaaaag ttttttatga gcgttttttg tgctcaaaaa agttttttac gagcgttttt
    15901 tgtgctcata gcaagataca aagagcgtca aactcaaaat aaaaatagaa aatctaacac
    15961 aaaaacttct gtttcgagga agatttatct ttttcatgta gagtttagct cgtgttcaag
    16021 ttccatcaaa cactaactgt acttgcaaaa tctcaccgat taaagtttga tttctacgtt
    16081 gacaccactt ggaagatcaa gtttcatcaa agcatcaaca gttttttgtg ttggattgat
    16141 gatgtctacc aaacgtttgt gtgtacgcat ttcaaattgt tcgcgagaat ctttgtattt
    16201 gtgagtcgca cgaataattg tgtaaagact gcgttcagtt ggaagtggaa ctggtccagc
    16261 aactgtagca cctgtacgtg ttgcagtttc aacgattttt tctgccgctg tatcaagtgt
    16321 acggtgttcg tacgctttca aacggatacg gatttttttg tttgccatct tttctcctct
    16381 cgtctattta cgataatagg ctagctcctc aagaaaaccg acacctgttg cgtggcaatg
    16441 caaccgagcg tgtcgcaacc tcttgtatca ttgctaaagc tgtattttta cagcaccaca
    16501 atataataac agaatcattt agtcattgca agctttttag gcattttttt caaaaaaaac
    16561 taccttccta atgaaaggta atttcttggt actttttaaa ttgtttagag agaataaacc
    16621 accgactggt attatctaac actgtcgcca tccagacccc tatgagtcca tattgccaaa
    16681 ccacaccaat cacataacca aggccaatgc gaattaccca cattcctatg gttgttgcat
    16741 agaaaggaag ctttgctttt cccaaaccct gccagacggc tgtataaact aaagtgcctg
    16801 ccgttgcggg agctcctagt aaagaaaaaa gtaaaacaac catggcggac ctttgagcat
    16861 cagtattctg agtaaatagc ggcaagagac taggacctag cagataggtc aaggctccca
    16921 taaccagcat catgagggtg gataaaataa aagcttctct aataatatac cttatctcag
    16981 tcaccttacc gccccccagt tgcctagcca ctagaataat tgttgccgtt gccatggcta
    17041 agccaggcat gtaattaaac tgagtcaagg tttctccaat agcattacct gccaaggccg
    17101 ttgtcccaaa gcgaacaaca atgccaataa ttaggacatc tcctgctctc atcatcaaac
    17161 gttcaccagc agcaggtagt gataaatcaa aaataatttt gtccaaaggt ctcatcaatc
    17221 gtttcgcaac ctgtttaata ggaataaact gacaaagtaa aaacacaccc actaaacgag
    17281 ataaaaccgt cgcccaagca acaccaagaa gactaaatcc ccatacatag atagacaagg
    17341 cagaaaaaat ggcattgagt acgtttatta ataagctcac ttgcatagga atcttaggat
    17401 acccttgagc tcgaacaata gctcctaagc tagttaaaag tcctagacta acaatcatac
    17461 cgccgacaat ggatagatat tgccctccaa ccaatgttac agaagcttca gctcctagcc
    17521 attctaacac ctgatgatgt ccaacaactg ataacaaccc taagccgacc gaaaggagga
    17581 gtgttacttg caagacacct gccatatagt ttaattgttt gttctgatta ttttctccaa
    17641 tacttcgagc aatcagacta gatacagcag ctcccagcgc gataaagagg gactgataaa
    17701 tactgataat gttgttagct atggagacac cagagactgc tacaagtcca atttgagcca
    17761 ccagataatt atcaaccatt cccattaaca tctgtaaaat attttctatc atagaaggca
    17821 gagctaaaga gaaaattttt cttctattat atatcattta tgtcccctaa taaaaaattc
    17881 ttgatcaaac gattttttca aacacagtca ctggactcat tcagttattt tggtccatta
    17941 atgaattcat aaagtctatc ttaatagcag agtcccaaga tacacgacac ttagtgctac
    18001 agtaacaatt gaccacatgc caatccttaa catttaccta acgtttataa ctaagaagac
    18061 gaagaacaaa aggactccaa acgaattttt tctattatat aatatattct tcatttagca
    18121 actttcaatg tatcaaaata gcactctcga gtcaaaaatg gtttctgata ctcgagagcg
    18181 ctattttatt tggaatcaag tttaaacaac ttaggcttat ctcatattta atacatttgt
    18241 atgtttagct gatgaaatct aagaccttgc gcccctggat taaaccacgt tccatttcat
    18301 caaagactcc tggagcagtg tcaactggaa ctttttcgac aaccggaaca accagacctt
    18361 ctgcaccaaa ggcaaaggct tcttccaagt ctttacgtgt ccctacaagt gatccgacca
    18421 ctttgatacc atctaaaaca gtttttacga tagacagttc catgtattct gatggaagac
    18481 ctacggctac aactgtccca ccggcacgga cactatcaat tgcttggtta aaagcaactt
    18541 tagaaacagc cgttaccaca acaccatgtg ctccaccggt tttttcttga atatagcctg
    18601 gaacatcttc aatttctttg ccgttaacta caatatctgc gccaacttct ttagctaact
    18661 caagtttatc attattaatg tccactgcga caacatgtgc attaaagact tttttagcgt
    18721 attgaacagc cagatttcca aggccaccag ccccaaagat aacaatccat tggcctggag
    18781 cagcacctgc ctctttaata gctttataag ttgttacacc agcacaagta atggaagaag
    18841 cttgagccgg gtctaaacct tctggaactt taactgcata atcagctgtt actactgcat
    18901 attcactcat tcctccatca acactgtatc cagcattttt aacactacga caaagtgtct
    18961 cacgtcctgt agtacagtat tcgcaatgac cacatccttc aaagaaccat gcaatagaga
    19021 cacgatcacc aacctttaag gatgttacgc cttctccaat ttcttctact ataccaatac
    19081 cttcgtgccc caaaatacgt cctggtacct gaccaaaatc gccatgtgca acgtgtaaat
    19141 cagtatgaca aacgccacag tattctactt taacaagcgc ttcaccatga ccaacatttg
    19201 gaagatcatg ctcaacaact tcgacacctg tactagcttg attaacaact acggctttca
    19261 tatcagtcct ccatctaata atgacttatt tgtaatcggt tacaaataaa ttgtacatct
    19321 tttcacaatg aaagtcaaca gaaacctgaa aagtttctga aacttaactg gttaatatta
    19381 tagctgtttg cctatctgca aaatacttaa ctacattttc tgacactgga tataaatgat
    19441 atatttagaa aataaaatga tttcttatga ttttaatcat aagaaatcat ttcctggtat
    19501 caacattaaa aatcacttac gtcgtcctgg acgttcagca taaccatagt aagcatcttc
    19561 aataatttct tgcatgtgat caaccattgg aagacgtggg ttagcaggtg aacattggtc
    19621 ttcataagca aggtaagcca attcacgaga atgttctttc cattcgtttt cgtcgatacc
    19681 ttgagctttg aagttcattt gaataccaac tcggcaaccc agatcataaa cagctttcgc
    19741 ataagattcc actgcttctt ctggtgtaga agctggaagc cctaacaatt tcgcaatgtc
    19801 ttggtatttt tcatcagcac ggtagtaatt atacttaggc catgttgctg ttttagctgg
    19861 acgagttcca ttatagcgga taacatacgg caaaagaatt gcatttgtac gtccgtgtac
    19921 ggtatggaat tgtgcgccaa ttttatgcgc cattgagtga gaaataccta agaaagcatt
    19981 ggcgaaagcc atacctgcca tagttgacgc attgtgcatc ttttcacgtg cttcaaaatc
    20041 ggctgtttta actgattttt caagattatc aaaaacaatt ttaatggctt gaagagctaa
    20101 accatccgta aagtcattgg ccatttgtga tacgtaagct tcggttgcgt gtgtcaaaac
    20161 gtccatacca gtatcagcag caataaagcc tggaacagtc aataccaaag ctgggtcaac
    20221 aatggctaca gttggtgtta atgagtaatc agcgattgga tatttacgat tatttgcttt
    20281 gtcagagata acggcaaatg gtgtcacctc tgaacctgtt ccagaagttg ttgagatagc
    20341 aacaaatttt gttttcttac caagttctgg gaatttgaac gcacgtttgc ggatatccat
    20401 gaatttttga acgaggtcat ggaaatcaac ttctggttgc tcgtagaaga gccacataac
    20461 tttggctgca tccataggag atcccccgcc aagggcaata atggtgtctg gtttgaaggt
    20521 acgcattaat tcagtacctt tcataacagt tgtaatgtct ggatctggtt ctacttcagc
    20581 aaagatctga taaacaactt tattgcgacg aagatcaagt tgttcaatga tacgatccaa
    20641 gaaaccaagc tcaaccatag cgtgatctgt aacaatcatg acacgttcaa cgtcacgaca
    20701 tttttgcaaa tattgaattg aatcacgttc gaagtatgtt tttgaaggaa ccttaaacca
    20761 ttgcatatta tttctacgtc ttcctacttt tttgatgttc aagagattta tagcactaac
    20821 gttatcacca actgcgttac gtccatacga accacaacca agagtcaatg atggtaagaa
    20881 agcattgtaa acatccccga taccaccaaa tgtagaaggt gaattccaga tgacgcggat
    20941 agcacggatt ctagttccaa attcttttgc caactctgca tctgctgtat gaatggcagc
    21001 tgagtgacca agtccattaa attcaaccat ttgacgagct ttttcaacac cgtcttcacg
    21061 tgattcagat ttcaaaacag caatgactgg tgataatttt tcccgtgtca aaggttcttt
    21121 ttcactaact tcagtacatt ctgcggcaag aatatttgtt ccttctggaa cagtaaatcc
    21181 agcttgtgct gcaatccaag tagctggttt tcctacaata tttggattta attttgcacc
    21241 agcacagttt ttgctatttg cttttgcacc aaaacagaat tcttcaagaa gggctttttc
    21301 ttttttatta acaaaataag tgtggtaaga tttgaattct gctacaaaat cgtcatagat
    21361 ttctttatcg atgataacag cttgttcaga ggcacagacc ataccattat caaatgattt
    21421 agacatcaca atatcatgag cggcttgacg gatattagct gatttttcaa cataagctgg
    21481 aacgttacca gcacctaccc caagggcagg tttcccacat gagtatgccg ctttaaccat
    21541 cgcatttcca cctgtcgcaa ggatggtggc aatgccgtca tgattcatca aagcatttgt
    21601 tgcttcaagt gatggtgttt caacccactg cacacaattt tcaggagcac cagcggcaat
    21661 agcagcatca cgaacaatac gagcggcatg cgctgatgat tcttgtgctg atgggtgaaa
    21721 ggcaaaaata attggattac gtgtttttaa cgagatcaaa gatttaaaga tagctgttga
    21781 agttgggtta gttgttggtg taatcccaca gataacgccc accggctcag caattaatgt
    21841 caaacctgtc acatcatctt cttcaataat tcctactgtt ttttgatggc gcatgttatt
    21901 aaccacatgc tcacaagcaa atagattttt tgttgcttta tcttcaaaga caccgcgacc
    21961 tgtttcttca taagcatgtt tagcaagttc accgtgagca tccaaagcag caacagaagc
    22021 ttttgctacg atataatcaa cttgttcttg gtcaagctta cgcatctctt caagagcagc
    22081 taaacctttt tgaacaagag catcaattgt cacagaaaca gaggttgttt caacagtatt
    22141 atgtccttca gtcatttgag actcctttat cttgttaaaa gtttcacaat tttgtttaca
    22201 aaattattat agcacttttt gaa
//
LOCUS       DAUDWO010000030        21448 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.030, whole genome shotgun sequence.
ACCESSION   DAUDWO010000030 DAUDWO010000000
VERSION     DAUDWO010000030.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21448)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21448)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21448
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.030"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            133..759
                     /locus_tag="VHC05_001235"
     CDS             133..759
                     /locus_tag="VHC05_001235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEQ5402543.1"
                     /translation="MKKYLKKIGKMMTKMYYDENPDSLHDIHEVKVELLNHPFTFLTD
                     SGVFSKKMVDFGSQVLLETLNFKENERVLDLGCGYGPLGISLAKVQRVDATLVDINNR
                     ALDLARKNATNNQVAVTIFQSNIYENISGHFEHIISNPPIRAGKRVVHSIIEKSIDFL
                     VVNGDLTIVIQKKQGAPSAKAKMATIFGNVEILRKDKGYYVLRSIKQA"
     gene            1412..1801
                     /locus_tag="VHC05_001236"
     CDS             1412..1801
                     /locus_tag="VHC05_001236"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HEQ5402544.1"
                     /translation="MGTTDLVSCAVQASEYAYVPYSHFPVGAALKTKDGTIYTGCNIE
                     NVSFGLTNCGERTAIFKAISDGHKELVEIAIYGETMQPVSPCGACRQVMAEFFAPSSL
                     VTLIAKNGQTVEMTVGDLLPYSFTDLI"
     gene            1895..2947
                     /locus_tag="VHC05_001237"
     CDS             1895..2947
                     /locus_tag="VHC05_001237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003058857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family protein"
                     /protein_id="HEQ5402545.1"
                     /translation="MNKKFISLGLASVAVLSLAACGNRGASKGGAAGKTDLKVAMVTD
                     TGGVDDKSFNQSAWEGLQSWGKEMGLQKGTGFDYFQSTSESEYATNLDTAVSGGYQLI
                     YGIGFALKDAIAKAAGDNEGVKFVIIDDIIEGKDNVASVTFADHEAAYLAGIAAAKTT
                     KTKTVGFVGGMEGTVITRFEKGFEAGVKSVDDTIQVKVDYAGSFGDAAKGKTIAAAQY
                     AAGADVIYQAAGGTGAGVFNEAKAINEKRSEADKVWVIGVDRDQKDEGKYTSKDGKEA
                     NFVLASSIKEVGKAVQLINKQVADKKFPGGKTTVYGLKDGGVEIATTNVSKEAVKAIK
                     EAKAKIKSGDIKVPEK"
     gene            3086..4618
                     /locus_tag="VHC05_001238"
     CDS             3086..4618
                     /locus_tag="VHC05_001238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402546.1"
                     /translation="MTQHVIEMREITKKFGDFVANDHINLNVRKGEIHALLGENGAGK
                     STLMNMLAGLLEPTSGEIVINDKPVQIDSPSKSAKLGIGMVHQHFMLVEAFTVAENII
                     LGNEVVKNGCLDLNQASKDIKVLSEKYGLAINPSAKVSDISVGAQQRVEILKTLYRGA
                     DILIFDEPTAVLTPAEIKELMTIIKNLVKEGKSIILITHKLDEIRAVADRVTVIRRGK
                     SIETVDVAGATSQDLAEMMVGRSVSFTTSKKAAEPKDVVLSIKNLEVDENRGIPAVKG
                     LSLDVRAGEIVGIAGIDGNGQSELIQAITGLRKVKSGSIMIKNNEVTHLSSRKITELS
                     VGHVPEDRHRDGLILDLSLAENTALQTYYKQPLSQNGILNYTKINDYARQLMKEFDVR
                     GANELVPARGFSGGNQQKAIIAREVDRDPDLLIVSQPTRGLDVGAIEYIHKRLIKERD
                     KGKAVLVVSFELDEILNLSDRIAVIHDGKIQGIVLPENTNKQELGILMAGGSIHKEEG
                     HV"
     gene            4611..5675
                     /locus_tag="VHC05_001239"
     CDS             4611..5675
                     /locus_tag="VHC05_001239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402547.1"
                     /translation="MSKNAQKIAVPLISVLLGFLLGAIIMVIFGYDPIWGYEGLFQIA
                     FGSVKNIGEIFRSMGPLILIALGFTVASRAGFFNVGLSGQALAGWISAGWFALLNPDM
                     PRPLLILMTALIGMIAGGIAGAIPGILRAYLGTSEVIVTIMMNYIILYVGNAIVQRGY
                     PESVKQSIDSTIQVSDNASYQTHWLSALTNNSRINIGIFFAIIAIALIWFLLNKTTLG
                     FEIRSVGLNPHASEYAGMSSKRTIILSMIISGALAGLGGVVEGLGTFENVFVQGSSLA
                     VGFDGMAVSLLAANSPLGIFFSSFLFGVLNIGAPGMNIAGIPPELVKVVTASIIFFVG
                     SHYLIERYIIRPKKLVKGGK"
     gene            5677..6633
                     /locus_tag="VHC05_001240"
     CDS             5677..6633
                     /locus_tag="VHC05_001240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402548.1"
                     /translation="MSLVTIFALLVSSMLIYATPLIFTSIGGTFSERSGVVNVGLEGI
                     MVMGAFSGIVFNLEFAETFGKATPWIAVLVGGIVGLIFSLIHAVATINFRADHIVSGT
                     VLNLLAPSFAVFLVKAMYGKGQTDNIQQSFGKFDFPGLSQIPVIGDIFFKNTSLIGYF
                     AIAFSFFAWFLLYKTRFGLRLRSVGEHPQAADTLGINVYLMKYYGVMISGFLGGIGGA
                     VYAQSISVNFAVTTILGPGFIALAAMIFGKWNPVGAMLSSLFFGLSQSLAVIGAQLPL
                     LEKIPTVYLQIAPYMVTIIILAAFFGQAVAPKADGINYIKSK"
     gene            complement(6846..8564)
                     /locus_tag="VHC05_001241"
     CDS             complement(6846..8564)
                     /locus_tag="VHC05_001241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HEQ5402549.1"
                     /translation="MTYTENFQKWLDFEQLPDYLRQELLSMDEKSKEDAFYTNLEFGT
                     AGMRGYIGAGTNRINIYVVRQATEGLAKLIETKGEEAKKRGVAIAYDSRHFSPEFAFE
                     SAQVLAQHGIKSYVFETLRPTPELSFAVRHLNAYAGIMVTASHNPAPFNGYKVYGQDG
                     GQLPPADADALTDFIRAIENPFAVELADLDESKSAGLIQVIGEDVDMEYLREVKDVNI
                     NQDLINNFGKDMKIVYTPLHGTGEMLTRRALAQAGFESVVVVESQAKADPDFSTVKSP
                     NPESQAAFALAEELGREVDADVLVATDPDADRLGVEIRQPDGSYKNLSGNQIGAIIAK
                     YILEAHKTAGTLPENAALAKSIVSTELVTKIAESYGATMFNVLTGFKFIAEKIQEFEE
                     KHNHTYMFGFEESFGYLIKPFVRDKDAIQAVLLVAEIAAYYRSRGLTLADGIDEIYKE
                     YGYFAEKTISVTLSGVDGAAEIKKIMNKFRENGPKQFNNTDIVLLEDFQKQTATKNDG
                     TISNLTTPPSNVLKYTLADDSWIAVRPSGTEPKIKFYIATIGDTLDIAQEKIANIETE
                     INTFVG"
     gene            complement(8739..9308)
                     /locus_tag="VHC05_001242"
     CDS             complement(8739..9308)
                     /locus_tag="VHC05_001242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEQ5402550.1"
                     /translation="MNHRKSADISRIAIFFAIMLVIHFVSSLVFNIWPIPIKPTLVHI
                     PVIIASVLYGPRIGAILGGLMGIISVITNTIILLPTNYLFSPFVDHGTFASLIIAIIP
                     RILIGITPYYCYKLIPNQFGLIVSGIIGSLTNTIFVLSGIFIFFATVFDGNIKALLTA
                     IISSNAIVEMIISAIITFVLIPTLSRLKR"
     gene            complement(9366..9911)
                     /gene="coaC"
                     /locus_tag="VHC05_001243"
     CDS             complement(9366..9911)
                     /gene="coaC"
                     /locus_tag="VHC05_001243"
                     /EC_number="4.1.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenoylcysteine decarboxylase"
                     /protein_id="HEQ5402551.1"
                     /translation="MTKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFI
                     TPLTLQVLSKNAIHLDVMDEHDPKVINHIELAKRTDLFIVAPASANTIAHLAYGFADN
                     IVTSVALALPATTPKLIAPAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDK
                     GPGALADIDVILTTIDTIWKL"
     gene            complement(9904..10596)
                     /gene="coaB"
                     /locus_tag="VHC05_001244"
     CDS             complement(9904..10596)
                     /gene="coaB"
                     /locus_tag="VHC05_001244"
                     /EC_number="6.3.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenate--cysteine ligase"
                     /protein_id="HEQ5402552.1"
                     /translation="MTMKLIITSGGTTEPIDAVRGITNHSTGQLGKLITERFLQYHHD
                     VTLVTTKTATKPLPNERLRIIEVETVNDLMAALKDQVPHHDILIHSMAVSDYTPVYMT
                     DLEQVSQADNLNCFLCEHNSEPKISSASDYQVLFLKKTPKVISYVKQWNPNIKLVGFK
                     LLVNVPQEELIKVARASLAKNHADYILANDLVDIQTGMHKALLISNNEVASADTKEAI
                     ADLLYERMTKHD"
     gene            10777..11628
                     /locus_tag="VHC05_001245"
     CDS             10777..11628
                     /locus_tag="VHC05_001245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase family protein"
                     /protein_id="HEQ5402553.1"
                     /translation="MKGRIVITIRDLTSLPIFVYGDGNKKVPGALSPFVWTEVFLKTI
                     NQEPNQLILHIWPMTRTVILGMLDRQLPYFELAKTEIGNNGYVPVTRNIGGLAVVADD
                     GILNFSLVIPDHFSESISISNAYLIMVDVIRESFSDYYQRIEYHEIKNSYCPGNFDLS
                     IAGRKFAGIAQRRIKKGIVVSIYLSVCGDQAARGQLIKAFYEAGTQGEVTKVNYPQID
                     PECMATLSELLETPFTVAEVLERLRLTLRQLGFSLTEKSPDQALLTNFDAVYERMQLE
                     VVRKEGK"
     gene            11625..12824
                     /locus_tag="VHC05_001246"
     CDS             11625..12824
                     /locus_tag="VHC05_001246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH-dependent flavin oxidoreductase"
                     /protein_id="HEQ5402554.1"
                     /translation="MKERFSPLFEPLTLPNGSQLDNRFVLSPMVTNSSTKDGYVTQDD
                     VSYALRRAASAPLQITGAAYVDPYGQLFEYGFSVTKDADISGLKELAQAMKAKGAKAV
                     LQLTHAGRFASHALTKYGFVYGPSYMQLRSPQPHEVKPLTGQQIEELIAAYAQATRRA
                     IQAGFDGVEVSSAQRLLIQTFFSTFSNKRTDSYGCQTLFNRSKLTLAVLQAVQQVIKQ
                     EAPDGFIFGFRATPEETRGNDIGYSIDEFLQLMDWVLNIAKLDYLAIASWGRHVFRNT
                     VRSPGPYYGRRVNQVVRDYLRNKLPVMATGGMNTPDKAIEALAHADFIGVSTPFVVDP
                     EFAHKIKEGCEESIHLRIRPADLKSLAIPQASFKDIVPLMDYGESLPKESRTLFRSLT
                     HNYKEIK"
     gene            12821..13819
                     /locus_tag="VHC05_001247"
     CDS             12821..13819
                     /locus_tag="VHC05_001247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="HEQ5402555.1"
                     /translation="MKVSILDYGVIDKEKTPQEALLETRCLAQVADKLGFHRFWVAEH
                     HNIYAFAISSPELLMMHLADHTKQIRIGSGGIMPLHYSSFKIAEWIMTLEALHPNRID
                     LGIGNSLGTTLVQRALSSIHCKDSYSQVVTELYQYLNPDHLSPLPIFVNPRGNTYPQI
                     WTLSNSLETAELAGQLGLGYTFGIFPYIPKDPITEAKRVSAHYRKAFRPSKLLKIPKL
                     ILAVFIVLSDTDEEAEALAKPLDIWMLGQQDFNEFKTYPDVEEARNYHLTEKQREAIA
                     ANRSRMVIGSPHTVKKQLDRLIEACQADELLAIPLVPEFANRQRTLELLADLYVTI"
     gene            13861..14193
                     /locus_tag="VHC05_001248"
     CDS             13861..14193
                     /locus_tag="VHC05_001248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine cleavage system protein H"
                     /protein_id="HEQ5402556.1"
                     /translation="MKKIANYLLIEKTDDRYTISMTPELQDDIGTIGYAEFTDNDHLA
                     VDDIILNLEASKTVMSVLSPLAGAVVEHNEAATLTPTLLNSEKAEENWIVVLTDVDQA
                     AFDALEDA"
     gene            14186..14998
                     /locus_tag="VHC05_001249"
     CDS             14186..14998
                     /locus_tag="VHC05_001249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989718.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-ADP-ribose hydrolase"
                     /protein_id="HEQ5402557.1"
                     /translation="MPSSFDLLGEMIGLLQTEQLTSSWACPLPNALIKRQDLWRALIN
                     QRPALPLSKDYLNLEDAYLDDWSASFVPVSVKDCQKTNYTSLFLYHGDIRYLAVDAIV
                     NAANSELLGCFIPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQAKLTSAYHL
                     PASYIIHTVGPRITKGHHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSISTGEFGF
                     PKKEAAQIAIKTVLKWQAEHPESKTLTIIFNTFTSEDKALYDTYLQKENNCE"
     gene            14991..15872
                     /locus_tag="VHC05_001250"
     CDS             14991..15872
                     /locus_tag="VHC05_001250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent deacetylase"
                     /protein_id="HEQ5402558.1"
                     /translation="MSNWTTYPQKNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTY
                     IGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLD
                     LKEILGTKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVI
                     RQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEH
                     KEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELT
                     EHIAQLISATKTIYQKS"
     gene            15919..16938
                     /locus_tag="VHC05_001251"
     CDS             15919..16938
                     /locus_tag="VHC05_001251"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HEQ5402559.1"
                     /translation="MYLIEPIRNGKRITDGAVALAMQVYVQENLFLDDDILFPYYCDP
                     KVEIGKFQNAVVETNQEYLKEHHIPVVRRDTGGGAVYVDSGAVNICYLINDNGIFGDF
                     KRTYQPAIEALHHLGATEVEMSGRNDLVIDGKKVSGAAMTIANGRVYGGYSLLLDVDF
                     EAMEKALKPNRKKIESKGIRSVRSRVGNIREHLAPQYQGITIEEFKDLMVCQLLQIET
                     ISQAKRYDLTEKDWQQIDALTERKYHNWEWNYGNAPQYRYHRDGRFTGGTVDIHLDIK
                     KGYIAACRIYGDFFGKADIAELEGHLIGTRMEKEDVLATLNATDLAPYLGAITAEELG
                     DLIFS"
     gene            17066..18736
                     /locus_tag="VHC05_001252"
     CDS             17066..18736
                     /locus_tag="VHC05_001252"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HEQ5402560.1"
                     /translation="MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEK
                     MKAVEANEPGKLILVTAINPTPAGEGKSTMSIGLADALNQMGKKTMLALREPSLGPVM
                     GIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRR
                     IIWKRVLDLNDRALRQVIVGLGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKR
                     LADIVVAYTYDRKPVYVRDLKVEGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIA
                     HGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKVPNLPKAPDAIVIVATLRAL
                     KMHGGVAKSDLAAENCEAVRLGFANLKRHVENMRQFKVPVVVAINEFVADTEAEIATL
                     KALCEEIKVPVELASVWANGAEGGIALAKTVVRVIDQEAADYKRLYSDEDTLEEKVIN
                     IVTQIYDGKAVQFGPKAKTQLKQFAEFGWDKLPVCMAKTQYSFSDNPSLLGAPTDFDI
                     TIREFVPKTGAGFIVGLTGDVMTMPGLPKVPAAMAMDVAENGTALGLF"
     gene            18821..20398
                     /gene="cls"
                     /locus_tag="VHC05_001253"
     CDS             18821..20398
                     /gene="cls"
                     /locus_tag="VHC05_001253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HEQ5402561.1"
                     /translation="MIIKKKAKVKYLLHKGKHGFLRGIFSRTTIIVLLIILQLVFLFQ
                     SYAWMEQYRVWITILESVFAITIVLYLVNSDMDAISRMTWLILIMIAPLLGSLFLIYT
                     KLDWGYRGLKQRINHLVDLSAPYLSDDDAILEVLKDSTSTTYHLVQYLERSRGNFPIY
                     NNTRVTYFPTGETFFDSLKEQLFLAKKYIFLEFFIIAEGQMWGEILSILEKKVSEGVE
                     VRVLFDGMNELSTLSSDYAKRLEQIGIKAKSFLPISPFISTYYNYRDHRKIVVIDGEV
                     SFTGGINLADEYINEVERFGHWKDAGLMLEGEATDSFLILFLQMWSITEKELIIDPYL
                     SDHSLKLPSDGYVIPYGDSPLDTDKIGKNVYIDILNHAKEYVYIMTPYLILDSEMEHA
                     LRFASERGVDIRIIMPGVPDKGVPYALAKTYYKALMSSGVKIYEYQPGFVHSKVFISD
                     NTKAVVGTINLDYRSLYHHFECATYLYRVSVIADIVNDFNEAQKQSLLMTSDHLTQRP
                     WYQKLIGLLVRTIAPLL"
     gene            20738..21076
                     /locus_tag="VHC05_001254"
     CDS             20738..21076
                     /locus_tag="VHC05_001254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402562.1"
                     /translation="MQIIKRDGHVADFDPDKIYQAIIKAARTVYVIDDTWRQNLTHVT
                     KKVVIDLEEAHVERPTINMVQSLVENRLMDAGYITIAEHYISYRLQRDLERNGYGDKI
                     VVHLRFEQIK"
BASE COUNT         6638 a         3600 c         4405 g         6805 t
ORIGIN      
        1 aaaaagccac acattcctag tacaattatc ctgctatatt ctaacaaata gttaaagttc
       61 ggtttttatt tgtaatatag agaaaattgt taagaaacaa gcgtcttgta aaccatttca
      121 aagtatgata gaatgaaaaa gtaccttaaa aagataggaa aaatgatgac aaagatgtat
      181 tatgatgaaa atccagatag cctacacgat attcatgaag taaaagtaga gctgcttaat
      241 catcccttta cttttttaac ggattcaggt gtcttttcaa agaaaatggt tgatttcggt
      301 agtcaagtat tattagagac actaaatttc aaggagaacg aacgtgtact ggacttaggt
      361 tgcggctatg gtcctcttgg gattagtcta gccaaggttc aaagggtaga cgcaacctta
      421 gtggacatca ataatcgtgc tcttgattta gctagaaaaa atgcaactaa taaccaagtg
      481 gcagtaacta tttttcaatc aaatatttat gaaaatatta gtggccattt tgagcatatt
      541 attagtaatc ctcctattag agcaggaaag agagtagttc atagcattat tgaaaaaagc
      601 atagattttt tagtggttaa tggtgactta acgattgtga ttcaaaaaaa acaaggagct
      661 cctagcgcta aagcaaaaat ggcaactatt tttggtaatg ttgagatact aaggaaagat
      721 aaaggttatt atgtattaag aagtataaag caagcctaat ttaaataatc aacaattgct
      781 catttaaatt aggtttgctt aaatagtaaa gagttatttt taaattatag ataactaata
      841 ttatactagg gtagcccctc tactcgagta acctttttta atgtatttta actgaaaaag
      901 gctttcataa ttttaaaaaa atgttaaaat aggtgtataa caactgatta ccaagagatt
      961 attatcatta tcttctaagg tgtcattgtt atggtgacaa tcaaccatac gctactaaag
     1021 ataggtagcg ttcgatcaca ggttgatcaa gtgattgaaa aatcaatatt tataatttta
     1081 caaatatctg tatcaatcca tgttgaatag tctatgcttc taaggtgtcg acgttaatgt
     1141 actgacggga ccgttatagt ctttcttttt ggagaaacgt cggatgccag tgaactagtt
     1201 gaagttaaag atgttaattc aaacagtgct gaagagattg atatcgtttt gaacggtcgt
     1261 ttacttcaaa gcaaagaaat taccagtcta tcgaagatga tataagtgct aaagttagat
     1321 cacgttaatt atctatcaag tcgggtgcat atttcgttaa agtatctaca ggggtttcaa
     1381 tagatgtagc tattatgaaa ggtgatgtta aatggggact actgatttag ttagttgtgc
     1441 tgtacaagct agtgagtatg cttatgtccc ttactctcat tttccagtag gagcagcttt
     1501 aaaaacaaaa gatggaacga tctatactgg ctgtaatatt gaaaatgtta gttttggtct
     1561 gacaaattgt ggagagcgaa cagctatatt taaagccata tctgatggtc ataaagaatt
     1621 ggttgaaatt gctatttatg gagaaactat gcaacctgta tctccttgtg gggcttgtcg
     1681 tcaggtaatg gcagaatttt ttgctccttc ttctttagtc actttaattg ctaaaaatgg
     1741 tcaaactgtt gaaatgactg ttggagattt actcccctat tcttttacag atttaatata
     1801 atctgcttta atttctgtta tctagccgtc ttggctttat atttactttc agcaacttat
     1861 ttgctagaaa tcttttttag gagggttcat attcatgaac aagaaattta ttagtcttgg
     1921 tttagcgtca gtggctgtgc tgagtttagc tgcttgtggt aatcgtggtg cttctaaagg
     1981 tggggcagca ggaaaaactg atttaaaagt tgcaatggtt accgatactg gtggtgtaga
     2041 tgataaatca ttcaaccaat cagcatggga aggtctgcaa tcttggggta aagaaatggg
     2101 ccttcaaaaa ggaacaggtt tcgattattt tcaatctaca agtgaatctg agtatgcaac
     2161 taatctcgat acagcagttt caggagggta tcaactgatt tatggtatcg gctttgcatt
     2221 gaaagatgct attgctaaag cagctggaga taatgaagga gttaagtttg ttattatcga
     2281 tgatattatc gaaggaaaag ataatgtagc cagtgttacc tttgccgacc atgaagctgc
     2341 ttatcttgca ggaattgcag ctgcaaaaac aacaaaaaca aaaacagttg gtttcgtggg
     2401 cggtatggaa ggaactgtca taactcgatt tgaaaaaggt tttgaagcag gagttaagtc
     2461 tgttgacgat acaatccaag ttaaagttga ttatgctgga tcatttggtg acgctgcaaa
     2521 aggaaaaaca atcgcagcag ctcagtatgc agcaggtgct gatgttattt accaggcagc
     2581 aggaggcact ggagcaggtg tatttaatga agcaaaagct attaatgaaa aacgtagtga
     2641 agctgataaa gtttgggtta ttggtgttga ccgtgatcaa aaagacgaag gaaaatacac
     2701 ttctaaagat ggcaaagaag caaactttgt acttgcatca tcaatcaaag aagttggtaa
     2761 agctgttcag ttaatcaaca agcaagtagc agataaaaaa ttccctggag gaaaaacaac
     2821 tgtctatggt ctaaaagatg gcggtgttga aatcgcaact acaaatgttt caaaagaagc
     2881 tgttaaagct attaaagaag cgaaagcaaa aattaaatct ggtgacatta aagttcctga
     2941 aaaatagtgt ttaagaacaa gaagcgcgac ctttgtcggt cgctcttttt aaactgagat
     3001 aatttttatc tcagtaaagt ttgtgatagg tgatagatca taggctttac tgaaataaaa
     3061 gattgcattg aaaggaaatg atcctatgac acagcatgtc attgaaatga gagaaatcac
     3121 gaaaaaattt ggtgattttg ttgcaaatga ccacattaac ttaaatgtca gaaaaggtga
     3181 gattcatgcc ttattgggtg aaaatggggc aggtaaatca actttgatga atatgctagc
     3241 tggtctctta gagcctacta gtggagaaat tgtcattaat gacaagccag ttcaaattga
     3301 ttcgccatct aaatcagcta agcttggtat cggaatggta catcaacatt tcatgttagt
     3361 agaagctttc acggttgctg agaatattat tttaggaaat gaagtagtga aaaatgggtg
     3421 tttagatctt aaccaagcat cgaaagatat taaggtacta tccgaaaaat atggccttgc
     3481 aatcaatcca tcagctaaag tttctgatat ttcagtagga gcacaacaac gtgttgagat
     3541 tttgaaaacc ttgtatcgtg gtgcagatat tcttatcttt gatgagccaa ctgccgtttt
     3601 aacacctgca gaaattaaag aattgatgac tatcattaag aatctcgtga aagaaggaaa
     3661 atcaattatt ttaattaccc ataaactgga cgagattcgt gctgtcgccg accgtgtcac
     3721 agttattcgt cgtggtaaga gtatcgaaac agttgacgtg gcaggagcaa cttcacaaga
     3781 tttagctgag atgatggtgg gacgctcggt ttcctttaca actagcaaaa aagctgctga
     3841 accaaaagat gtggtcttat ccatcaaaaa tcttgaagta gatgaaaata gagggattcc
     3901 agcggttaag gggctatctc tagatgtccg agctggtgaa attgtaggga ttgctggaat
     3961 tgacggaaat ggtcaatctg agttaattca agctattaca ggtttacgta aagtcaaatc
     4021 tggaagtatt atgattaaaa acaatgaagt cactcatttg tcttcacgca aaattactga
     4081 gttatcagtg ggtcacgtgc cagaagatcg tcatcgagat ggtttgatac tagatctttc
     4141 tttagctgaa aatacagcct tacaaaccta ttacaaacaa cctctaagtc aaaatggaat
     4201 cttaaattat actaaaatta atgactatgc tcgtcaatta atgaaagaat ttgatgttcg
     4261 cggagccaat gagctagtac cagctagagg attttctggt ggtaaccaac aaaaggccat
     4321 tattgctcgt gaagtggacc gtgatccaga tttacttatt gttagccaac caacacgtgg
     4381 tcttgacgta ggagctattg aatatatcca taagcgtttg attaaagaac gtgataaagg
     4441 taaagctgtc ctcgttgtta gttttgaact tgatgaaata ttgaatttat ctgatcgaat
     4501 tgctgttatt catgatggta aaattcaagg tatcgtattg ccagaaaata ccaataaaca
     4561 agaattgggt attttaatgg caggtggttc aattcataag gaggaaggtc atgtctaaaa
     4621 atgcgcaaaa aattgctgta ccattgattt ctgtcttgct aggattttta cttggcgcta
     4681 ttattatggt tatctttggt tatgatccta tctgggggta tgaaggttta ttccaaattg
     4741 cctttggtag tgttaaaaat attggagaaa tattccgttc aatggggcca ttgattttaa
     4801 tagcgcttgg ctttactgtt gctagccgtg caggcttctt taacgttggt ttgtctggac
     4861 aggctttagc tggatggatt tcagcaggtt ggtttgcact cttaaatcca gatatgcctc
     4921 gtccattatt gattcttatg acagctctta tcggaatgat tgctggtggt attgctggag
     4981 ctattccagg gatacttcgt gcttatcttg gtacaagtga agttatcgtt acgattatga
     5041 tgaactacat cattttatat gtcggaaatg ctattgttca acgtggttat cctgagagtg
     5101 tcaaacaaag tattgattca actattcaag ttagtgataa tgctagttat caaacgcatt
     5161 ggttatcagc cctaactaat aactctcgta ttaatattgg tattttcttt gccattattg
     5221 ccattgccct aatctggttc ttgcttaaca aaactacttt aggttttgag attcgttcag
     5281 ttggtctcaa cccacatgct tcagaatacg cagggatgtc atcaaaacgt actatcattt
     5341 tatcaatgat tatctctgga gctcttgcag gtcttggagg agtagttgaa ggtctaggaa
     5401 cctttgaaaa tgtttttgta caaggatctt ctttagcagt tggttttgac ggtatggcag
     5461 ttagcttatt agcagcaaat tcaccgcttg gaatattttt ctcatcattc ctatttggtg
     5521 tcttaaatat tggtgctcca ggaatgaata ttgcaggcat tccaccagaa cttgttaaag
     5581 tagtaactgc atcaatcatt ttctttgttg gttcacatta cctcattgaa cgttacatta
     5641 ttcgccctaa aaaattagtg aaaggtggta aataagatga gtttagtaac aatttttgcc
     5701 ttattggtgt catctatgct tatttatgca acaccactca ttttcacaag tattggagga
     5761 actttttcag agcgctcagg cgttgttaat gttggtttag aaggtatcat ggtcatggga
     5821 gcgttctctg ggattgtttt caacttagag tttgctgaaa catttggaaa agcaacgcct
     5881 tggatagccg ttttagtcgg tggtattgtt ggtttgattt tttctttgat tcacgctgta
     5941 gcaaccatca actttcgagc tgaccacatt gtcagtggta cagtgttgaa cttgttagca
     6001 ccttcttttg ctgtcttctt ggttaaagct atgtacggta agggacaaac agacaacatt
     6061 caacaatctt ttgggaagtt tgatttccca ggtttatcac aaattcctgt gattggtgat
     6121 attttcttta aaaatactag ccttattggt tacttcgcca ttgctttttc gttctttgct
     6181 tggtttttgc tttataaaac caggtttggt ctgcgtttac gatcagttgg ggaacaccct
     6241 caggcagctg acacacttgg tattaacgtc tatttgatga aatactatgg tgtgatgatc
     6301 tcaggttttc ttggtggaat aggtggagct gtttatgctc agtcaatctc cgttaacttt
     6361 gctgtaacaa ctatcttagg tcctggattt attgctttgg cagctatgat ctttggtaaa
     6421 tggaatccag ttggcgccat gctatctagt cttttctttg gcttatcgca aagtttagcc
     6481 gttattggtg ctcaattacc attactagaa aagattccaa cggtttactt acagattgca
     6541 ccttatatgg taacgattat tattttagct gctttctttg gtcaagcagt tgcaccaaaa
     6601 gctgatggaa tcaactatat taaatctaaa taacgttata ttagtaagcc tcttagtgag
     6661 gtttaacagc actcctaaag caagatagtt aggtctagct ttaagggtgc ttttttggga
     6721 cttaccgcaa gtttggattg ccagtcacca tcacaataga agcaagaata gactaaaaag
     6781 aactaagtca gcggcttagt tctttttgct tgtctttcgt ttttactgat agctcttaag
     6841 ttgttttagc caacaaaggt attgatttct gtttcaatgt tagcaatttt ttcttgagcg
     6901 atgtcaagag tatcacctat tgtggcaata tagaacttga tttttggttc agttcctgaa
     6961 gggcgaactg caatccatga atcatcagct aacgtgtact tcaaaacatt acttggagga
     7021 gttgttaagt tagatattgt tccatcattt ttagtagcgg tttgtttttg gaaatcttct
     7081 aataatacaa tatcagtatt gttaaattgt tttggaccat tttcacggaa tttgttcata
     7141 atcttcttaa tttcagcagc tccatccaca cctgaaagtg ttactgaaat cgttttttca
     7201 gcaaaatagc catattcttt gtaaatttca tcaataccat ctgcaagtgt taaaccacgc
     7261 gaacggtaat aagccgcgat ctcagcaacc aaaagaactg cttgaatagc gtctttatca
     7321 cggacaaatg gtttaataag atatccgaag ctttcttcaa aaccaaacat ataggtgtgg
     7381 ttatgttttt cttcaaactc ttgaattttc tcagcgatga atttgaatcc agttaaaacg
     7441 ttaaacattg tagcgccata actttcggca atttttgtta ctaattctgt tgatacgatt
     7501 gatttagcga gagcagcatt ttctggaagt gttcctgctg ttttatgagc ttccaggatg
     7561 tatttcgcaa taatcgctcc aatttgattt ccagaaagat ttttataaga accatctggt
     7621 tggcgaattt caacgcctag gcggtctgca tcaggatcgg tagctactaa gacatctgca
     7681 tcaacttctc gtccgagttc ttcagcaaga gcaaaggcag cttggctttc agggttaggc
     7741 gatttaacag tagaaaagtc tggatctgcc ttagcttgtg attctactac aacaacagat
     7801 tcaaaaccgg cttgagcaag ggcacggcgt gtcaacatct caccagttcc gtggagagga
     7861 gtatagacaa ttttcatgtc ttttccaaag ttattgatta aatcttgatt gatattaaca
     7921 tctttaacct ctctaagata ttccatatca acatcttcac cgataacttg aataagacct
     7981 gctgatttgc tttcatctaa atcagcaagt tcaactgcaa atggattttc aatagcacgg
     8041 ataaagtctg ttagtgcatc agcatcagct ggtggtagtt gacctccgtc ttgtccatag
     8101 actttataac cattgaaagg tgctggattg tggcttgcag taaccataat accagcatag
     8161 gcatttaaat ggcgaacagc aaaagaaagt tctggtgttg gacgaagagt ttcaaatacg
     8221 taagatttaa ttccatgctg tgccaagacc tgtgcagatt caaaagcaaa ttctggagag
     8281 aagtggcgcg aatcataagc gatggctaca ccacgttttt tagcttcctc tcccttagtt
     8341 tcgattaatt ttgctaatcc ttcggttgct tgacggacaa cataaatatt aatacgattt
     8401 gtaccagcac caatataacc acgcatacca gcagtaccaa attctaagtt tgtgtaaaaa
     8461 gcatcttctt ttgatttttc atccattgat agtaattctt gacgaagata gtcaggaagc
     8521 tgctcaaaat ctaaccattt ttgaaaattt tctgtgtaag tcattgaaat actccttcaa
     8581 tatttataaa cgctttcatt atatcatttt gaagaaaaaa aacactaatt atttgcagct
     8641 gtttacaaaa ctttttccat attttcaagt agctaatgta agaaagttaa aataaccaag
     8701 tttttaaaag agaaaaactc ggttattgtg aaagctaatt acctttttag tcttgatagt
     8761 gttggaataa gtacaaaggt aataatagct gagatgatca tctcaacaat agcgtttgat
     8821 gagatgatgg ctgttagtag tgctttaata tttccatcaa aaactgtcgc gaaaaaaata
     8881 aatatcccag ataatacaaa tatagtattt gttagagaac caatgatacc ggagactatt
     8941 aaaccaaact gattaggaat caatttatag caataataag gggtaatacc aatcaaaata
     9001 cgtgggataa tagcaattat taaagaagcg aaagttccat gatcgacaaa aggtgaaaag
     9061 agataatttg taggcagtag aatgatggta tttgtaatga cacttataat ccccattaat
     9121 cctcctaaaa tagcacctat ccttgggcca tataagacag aagcaataat aactgggata
     9181 tggacaagcg ttggtttgat tggaataggc caaatattaa agacaagact gctcacaaaa
     9241 tgaatgacta acatgatggc aaaaaagata gcaatacgag aaatatctgc tgatttacgg
     9301 tgattcattt tactctccaa aaaatataat acttaattct aaaaaggtga tcagaaaaac
     9361 gactgttaaa gtttccaaat cgtatcaata gtagttaaga taacatcaat atcagccaaa
     9421 gcaccaggtc ctttatctcc acaggctaat aagctagatt ttggaggaat ttctgtaaac
     9481 cctattgtcg ataagcgttt aatattttct tgagtaatag ggttttgata cattttggta
     9541 ttcatggctg gggctattaa ttttggtgtg gtagctggta gggcaagagc aacacttgtt
     9601 acaatattat cagcgaatcc atatgctaga tgagcaatag tattagcaga ggcaggtgca
     9661 acaataaata aatctgtgcg ttttgctaat tcgatatggt tgataacttt tgggtcatgc
     9721 tcatccataa catctaaatg aatagcattt tttgataaca cttgcagggt taatggtgta
     9781 ataaattgtg tagcagcctg agtcattatg atgtgaacat catagccaat tttagttaat
     9841 tgactcgtaa gatctgctgc tttataggca gatatactac cagaaacagc taaggtaata
     9901 tgtttagtca tgtttggtca tcctttcgta taataagtca gcaattgcct ctttggtatc
     9961 tgcagatgca acttcgttat tggatatcaa aagagccttg tgcatacctg tttggatatc
    10021 aactaaatca ttggcgagaa tataatcagc atggttttta gctagacttg ctctggctac
    10081 tttaattaac tcttcttgag gcacattaac tagaagttta aagccgacta gtttaatatt
    10141 aggattccac tgtttaacat aagagataac tttgggtgtt tttttcaaaa aaagaacctg
    10201 ataatcagat gcagatgaga ttttcggctc actgttatgt tcacatagaa aacaattaag
    10261 gttatcagct tgagagactt gttccaaatc agtcatgtag actggagtat agtcagaaac
    10321 agccatacta tgaattagaa tgtcatggtg aggaacctga tctttgagtg cagccattaa
    10381 gtcgttaact gtttccactt caataatcct taggcgctca tttggcaggg gtttagtggc
    10441 tgttttagta gtgactaggg taacgtcatg atgatattgt aaaaatcgct ctgtgattaa
    10501 ttttccaagt tgcccagttg agtgattagt gatacctcgt actgcatcta taggttcagt
    10561 tgttccacct gatgttatta ttaatttcat agtcatattt tatcaaaaaa ggagctgata
    10621 gtaaacggaa gataatgacg ccagacattg tcttccgttt gtattaatat ggaatagtaa
    10681 tagatttcta gtaattaaaa cgaagttctg gaaagcaaga cactatagta gctaaaatct
    10741 aaattttaag gtaaaatagg gcaagcggtt tcaagtgtga aaggaagaat tgtgataact
    10801 attagagatt taacgtcact gccgattttt gtttacggtg atggaaataa aaaagttcca
    10861 ggagctttga gtccttttgt gtggacagag gtgtttttaa aaactatcaa tcaagaacct
    10921 aatcaactga tcttacatat ttggccgatg acaagaacag ttatattagg aatgttagat
    10981 agacagcttc cctactttga gcttgctaaa acagagattg gcaataatgg ttatgttcct
    11041 gttactcgta atattggcgg tttggctgtt gtcgctgatg atgggatttt gaatttttcg
    11101 cttgttattc cagaccattt ttcggaatct atcagtatta gtaatgctta tttaataatg
    11161 gttgatgtca ttagagagag tttttcggat tattatcagc gtattgaata tcacgaaatt
    11221 aaaaattctt attgccctgg taattttgat cttagtattg caggccgcaa gtttgcaggt
    11281 atcgcccagc gtcgtatcaa aaagggaatt gttgtgtcta tttacttgag cgtttgtggg
    11341 gatcaagcag cgcgtggtca actcatcaag gctttttatg aggctggaac acaaggagaa
    11401 gttaccaagg ttaattaccc tcaaattgat ccagaatgca tggcaactct ttcagaactc
    11461 cttgagacgc cttttacagt ggcagaagtc cttgaacgtc ttcgattgac cttgcgacag
    11521 cttggctttt ccctcacgga aaaaagtcca gatcaagcct tactgactaa ttttgatgct
    11581 gtctatgaac ggatgcagct agaagtcgtt agaaaggaag gcaaatgaaa gaaagattta
    11641 gtcctttatt tgagcctttg actttgccaa atgggagtca attggataat cgctttgttt
    11701 tgtctcctat ggtgaccaac tcatccacaa aagacggtta tgtcacccaa gatgatgtat
    11761 cctatgcttt gagacgagca gcttctgccc ctctacaaat tacaggagcg gcctatgtgg
    11821 atccttatgg tcaattgttt gaatatggtt ttagtgttac aaaagatgcc gatatttctg
    11881 gcttgaaaga gctagctcaa gcgatgaagg caaagggagc taaagctgtc ttacaactga
    11941 cccacgctgg ccggtttgct agccatgcct tgactaaata tggctttgtc tatgggccta
    12001 gttacatgca gttgagatct ccccaacctc atgaagtcaa acctttaaca ggtcagcaaa
    12061 tagaggaatt gattgcagct tacgctcagg ccactcggcg ggcaattcaa gcaggctttg
    12121 atggcgtgga agtatcttcg gcgcagcgct tattgattca aacgttcttt tcgacttttt
    12181 cgaacaagag gacagatagt tatggttgtc aaacactttt taatcgctct aagttaactc
    12241 tagctgtttt gcaagctgtt caacaggtga ttaaacaaga agctcctgat gggtttattt
    12301 ttggatttcg tgctacacca gaagaaacta ggggaaatga tattggttat agtattgacg
    12361 aatttttgca gttgatggat tgggtactta atattgcaaa acttgattat ttagcgatag
    12421 caagttgggg ccgtcatgta tttcgaaata ctgttcgttc tcctggccct tattatggaa
    12481 ggcgagttaa tcaggtagtt agagattatt taagaaataa gctacctgtt atggctacag
    12541 ggggaatgaa cacacctgac aaagctattg aagcactagc tcatgctgat tttattggag
    12601 tatctacacc ttttgtcgtg gatccagaat ttgctcataa aatcaaagaa gggtgcgaag
    12661 agagtattca tttaaggatt cgacctgctg atttgaaaag tttagcgatt cctcaggctt
    12721 ctttcaaaga tattgtacct ttgatggact acggggaatc attgcctaaa gaatcaagaa
    12781 ctttatttcg tagtcttact cacaattata aggagattaa atgaaagtca gtattcttga
    12841 ttatggggtg attgataagg aaaaaacacc ccaagaagct ttattagaaa cgcgctgctt
    12901 agcacaagta gccgacaaac ttggttttca tcgtttttgg gtagcagagc atcataatat
    12961 ttatgccttt gcaataagca gtccagagct gttgatgatg catttagcag atcataccaa
    13021 acagattcgg ataggttcag gaggtattat gcctctacat tatagtagct ttaagattgc
    13081 agaatggata atgactttag aggccttgca ccctaatcgg attgatttag gtattggcaa
    13141 ctctttagga actacgttag ttcaaagagc tctatcaagt atccattgca aagacagcta
    13201 tagtcaggtt gtcacagaat tataccagta tcttaatcct gatcatttgt caccactacc
    13261 gatttttgtt aaccctaggg gtaatactta ccctcagatt tggacgctaa gcaatagttt
    13321 ggagacagca gaactggctg gtcaattagg tttaggctat acctttggta ttttccccta
    13381 tataccaaaa gatcctataa cagaagctaa aagagtatcg gcacattata gaaaggcttt
    13441 taggccttca aagctattaa aaatccccaa gttaatatta gcagttttta ttgtcctttc
    13501 tgataccgac gaggaagcag aagctttggc taaaccgttg gacatttgga tgcttggtca
    13561 gcaagatttt aatgaattta agacctaccc tgatgttgag gaggctagaa actatcactt
    13621 aacagagaaa caaagagaag ccattgcagc aaatcgtagt cgcatggtta ttggatcacc
    13681 tcacacagtc aagaaacaat tggataggct gatagaagct tgtcaagctg acgaattatt
    13741 agccatcccc ttagttcctg aatttgccaa tagacaacga accttagagc tgctagcaga
    13801 cttatacgtg accatttaac cttaccaaaa acaattccct aaactgaaag gaaagaaaca
    13861 atgaaaaaaa ttgcaaatta cttattaatt gagaaaacag atgaccgcta taccattagc
    13921 atgacaccag aattacaaga cgatattggt actattggtt acgctgaatt tacggataac
    13981 gaccaccttg ccgttgatga cattatctta aatctagagg cttctaagac cgtcatgtct
    14041 gtcttgtcac cattggctgg ggcagttgtt gagcacaatg aggcagccac actaacacca
    14101 acccttttga attcagaaaa agctgaggaa aattggattg ttgtgctaac agatgttgat
    14161 caagcagctt ttgatgcctt agaagatgcc tagttcattt gatttattag gggaaatgat
    14221 tggtctgttg caaacagagc agcttactag ttcttgggcc tgtcccttgc ctaatgcttt
    14281 aataaagcga caagacttgt ggcgggcgct cattaaccag cgccctgctt tgcctttatc
    14341 aaaagattac ttgaatctgg aagatgctta tctagatgat tggagtgctt cttttgttcc
    14401 tgtatcagtc aaggactgcc aaaaaactaa ttataccagt ctttttcttt accatgggga
    14461 tattaggtac cttgctgtgg atgctattgt caatgctgct aatagtgagt tattgggatg
    14521 ttttattcct aaccatggct gtattgataa tgcgattcat acgtttgccg gaagtcgttt
    14581 acgcttagct tgtcaggcaa tcatgactga acaaggccgt aaggaagcca ttggccaagc
    14641 aaagcttacc agtgcttatc atctaccagc ctcttatatt attcataccg tagggccaag
    14701 aattaccaaa ggacaccacg tttctccgat tcgagctgat ttgttagcac gttgttatcg
    14761 ttctagtctt gatttggcgg ttaaagcagg attgactagc ctagcttttt gctctatttc
    14821 aacaggagaa tttggctttc ctaaaaaaga agccgctcag attgctatta agacagtttt
    14881 aaaatggcaa gcagaacatc cagaatctaa gaccttaact atcattttta atacctttac
    14941 atcagaagac aaggccttat acgacactta tttgcaaaag gagaataact gtgagtaatt
    15001 ggacaaccta tcctcagaaa aacctcaccc aggcagaaca actggcccaa ttaatcaaag
    15061 aagcagatgc acttgtagtt ggtattggag ctggcatgtc tgcagctgat ggttttactt
    15121 atatcgggcc gcgttttgag acggcattcc cagattttat tgctaagtat cagtttttgg
    15181 atatgctgca agctagcctt tttgattttg aagattggca agaatattgg gcttttcaaa
    15241 gtcgctttgt cgctttgaat tatcttgatc agcccgtagg ccagtcttat cttgatttaa
    15301 aagagatttt gggaaccaaa gactatcata ttattactac taatgctgat aatgcttttt
    15361 gggtggctgg ttatgatcct cataacattt ttcacattca aggagaatat ggtttgtggc
    15421 aatgtagcca gcactgccat cagcaaactt ataaggacga tacggtcatc cgtcaaatga
    15481 tcgcagagca aaaaaacatg aaagtcccag gtcaactgat tcctcattgc cctgaatgtg
    15541 aggcgccttt tgaaatcaat aagcgtaatg aagaaaaagg aatggttgaa gatgctgact
    15601 ttcatgccca aaaagcacgt tatgaggctt ttttatcaga acataaagag ggtaaagtgc
    15661 tttatctaga aattggtgtg ggacatacga cgcctcagtt tatcaaacac cccttttgga
    15721 aacgtgtctc agaaaaccct aatgccttat tcgttacctt gaatcacaaa cattaccgca
    15781 tccctctgtc aataaggcga caaagcctag aactgacaga acacattgca caattgatta
    15841 gcgccacaaa aaccatttac caaaaatcgt aaccaaagcc aatagacggt taattaagag
    15901 atagagaagg agactaacat gtaccttatt gaaccgattc gtaacggtaa acgtatcacc
    15961 gatggagctg ttgctctagc catgcaagtt tatgttcaag aaaatctatt tttagatgat
    16021 gatattttat ttccctacta ttgtgatccc aaagttgaaa ttggaaaatt ccagaatgca
    16081 gttgtagaaa ctaatcaaga gtatttaaaa gagcatcata tccctgttgt tcgcagagat
    16141 actggcggtg gtgccgttta tgtagattct ggtgctgtta atatttgcta cttgattaat
    16201 gataatggta tttttggtga ttttaaaaga acctatcagc ccgctattga agcccttcat
    16261 catttgggag caacagaggt tgaaatgtct ggacggaatg acttggttat tgatgggaaa
    16321 aaggtatctg gcgctgcgat gactattgct aatggccgtg tttatggggg atattccctt
    16381 ttgctagatg tggactttga agccatggaa aaagcattaa aacctaatcg caaaaaaatt
    16441 gaatcaaaag gcatcaggtc agttcgtagt cgcgttggaa acatcagaga acatttagca
    16501 ccacaatacc aaggtattac gattgaagag ttcaaagatt taatggtttg ccaattgtta
    16561 cagattgaga cgattagcca agctaagcgt tatgatttaa cggaaaaaga ctggcaacaa
    16621 attgatgctt taacagagcg taaatatcac aattgggaat ggaattatgg caacgcgcct
    16681 caataccgtt accatagaga tggccgtttt accggtggaa cagtagatat tcatttagat
    16741 attaaaaaag gctatattgc agcttgtcgc atttacggag atttttttgg caaggcagac
    16801 attgcagaac ttgaaggtca cttgatagga acacgaatgg aaaaagagga tgtcttagct
    16861 accctcaatg caactgattt agccccttat ttaggtgcga ttacagcaga agaattagga
    16921 gatttgatat tttcttgata aaaaagatac ctcagactgg taaagcgcga ttaaaaacga
    16981 acaataattg ttttaattca aataaatgta cgcatgatat ggattgtgat ataatgacgt
    17041 cattacgtaa aattgaggag tcatcatgaa atcagatatc gaaattgccc aaagtgtcgc
    17101 cttacaacca atcactgaca ttgttaaaaa ggttggaata gacggcgatg acattgagct
    17161 ttatggcaaa tataaggcta aattgtcttt tgagaaaatg aaagctgtcg aagctaatga
    17221 gcctggaaaa ttaatcttgg taactgctat taaccctact ccagcaggag aaggaaaatc
    17281 aaccatgtct attggactgg cagatgcctt aaatcaaatg ggaaaaaaaa ccatgcttgc
    17341 cttacgtgaa ccctcccttg gtcctgttat ggggattaaa ggcggggcag caggtggtgg
    17401 ttatgcccaa gtattgccta tggaagacat taatcttcac tttactggtg acatgcatgc
    17461 cattacaacc gctaataatg cattatctgc tttgattgac aatcatttgc agcaaggaaa
    17521 cgatttagga attgatcctc gccgcattat ttggaagcgc gtgttggacc ttaatgatcg
    17581 cgctcttcgt caggtaattg ttggcttagg tagtccagtg aatggtgtgc cacgcgaaga
    17641 tgggtttgat atcacagtag cttctgaaat catggcaatt ttatgtttgg caactgactt
    17701 aaaagatcta aagaaacgtc ttgctgatat cgtcgtggct tatacctatg atcgtaagcc
    17761 tgtctatgtg cgtgacttga aggttgaagg agcattgaca ttaattctaa aagatgctat
    17821 caagccaaat ttggtgcaga ctatttatgg aacaccagct cttattcatg gggggccatt
    17881 tgctaatatt gctcatggtt gtaattctgt ccttgctacc tcaacagctt tgcgattagc
    17941 agattacact gttaccgaag caggattcgg ggccgaccta ggagctgaaa aattcctaaa
    18001 tatcaaagta cctaatcttc ctaaagcacc agatgctatc gttattgttg caaccttgcg
    18061 cgctcttaaa atgcatggag gtgtcgccaa atcagattta gccgctgaaa attgtgaggc
    18121 tgttcgctta ggatttgcca acttaaaacg tcacgtggaa aacatgcgcc aattcaaagt
    18181 tccagttgtg gtggctatca atgaatttgt agcagatacc gaggctgaaa ttgctacctt
    18241 aaaagcgctt tgtgaagaga ttaaggttcc agtagaatta gccagtgttt gggcaaatgg
    18301 agctgaggga ggcatagcat tagctaaaac agtggttcgt gtgattgatc aagaagctgc
    18361 tgactacaaa cgtctctatt cagatgagga tactttggaa gaaaaagtga tcaatatcgt
    18421 tacccagatt tatgatggca aagctgttca atttggcccc aaggccaaaa cacaattgaa
    18481 gcagttcgca gaattcggtt gggataaatt gcctgtttgt atggctaaga cccaatacag
    18541 tttttcagat aacccatcct tgcttggagc gccaaccgat tttgacatta ccattcgtga
    18601 atttgttcct aaaacaggag caggttttat tgttggttta acaggtgatg tgatgaccat
    18661 gcctggtttg cctaaagttc cagctgccat ggcaatggac gtagcagaaa atggcacagc
    18721 cctcggtctc ttttaggaaa aattgctcga ataattcgag caagcgctcc tttcttcccg
    18781 ctttactgtg atataataag gtaaatgaga ttttggaggg atgattatca aaaagaaagc
    18841 aaaagtaaaa tatttgctcc ataaagggaa acatggattt ttaagaggaa tttttagtag
    18901 aacaacaatc attgtgttat taattatttt gcaattagtt ttcttatttc aatcttatgc
    18961 ctggatggag cagtaccgtg tttggataac gattcttgaa agtgtctttg ctattactat
    19021 tgttttatat ttagttaata gtgatatgga tgctatttca agaatgacgt ggttaatttt
    19081 gattatgatt gctccattac tagggtcact gtttttaatt tatacaaaat tggattgggg
    19141 ttacagaggg ctaaaacaga gaataaatca tcttgtagat ctgtctgcac cttaccttag
    19201 cgatgatgac gctatattag aggtattaaa ggatagcaca tcaaccacat atcatttagt
    19261 acagtactta gaaagaagtc gtggcaactt tccgatttat aataatacaa gggtaactta
    19321 cttcccaaca ggtgaaactt tttttgatag tttaaaagaa cagttattct tagctaaaaa
    19381 gtacattttt cttgaatttt ttattattgc agaaggccaa atgtggggag aaatccttag
    19441 tattctagaa aaaaaagtca gtgaaggtgt agaagttagg gtgttgtttg atggcatgaa
    19501 cgaactatca acgctatcat cagattacgc caagagatta gaacaaatag ggattaaagc
    19561 taaatcattt ttaccgattt caccctttat ctctacctat tacaattatc gagatcaccg
    19621 aaaaattgtc gttattgatg gggaggtatc attcactgga ggtattaatc tagcagatga
    19681 gtacattaat gaagtagagc gttttggcca ctggaaagat gctggtttaa tgcttgaggg
    19741 tgaagcaaca gacagctttt taattttgtt tttacaaatg tggtctatca cagaaaaaga
    19801 actgattatt gatccttatc tttcagatca ttctttaaaa cttccttcag atggctatgt
    19861 tattccctac ggtgattccc cgcttgatac tgataaaata ggtaaaaatg tttatataga
    19921 cattttaaat catgctaaag agtacgttta tatcatgaca ccttacctta ttttagatag
    19981 cgagatggaa cacgctttac ggtttgcatc agaacgtgga gtagatatcc gaattattat
    20041 gccaggagtg ccagataagg gggtaccata tgccttagct aaaacctatt ataaagcttt
    20101 gatgtcttct ggagtaaaaa tttatgagta tcaaccaggg ttcgttcatt caaaggtatt
    20161 tatctctgat aatacaaaag cagttgtcgg aacaattaac ttagactatc gtagccttta
    20221 tcatcatttt gaatgcgcga cttatttata tcgtgtgtca gttattgctg atattgtgaa
    20281 tgactttaat gaagctcaaa agcaatcact attgatgaca tcagatcatt tgacgcaacg
    20341 tccttggtat caaaaattga taggattatt agtacgaaca attgcccctc tcttgtaatt
    20401 ttcgtaaaat atgttataat atctgtatgc gatgagtcga ttgtgactgc aaagtcactt
    20461 ttgcgcaggg gaggtcatta aggcgggaag ccgactttga taatctgtgt gaaccatttt
    20521 atcacaatct tatttattaa gaatgcccct tggattgaga tattctcaat ccttttttta
    20581 attttattat cttagttaaa attcagaatg tatcagtgat tactgtgttt caaaataaga
    20641 aagtagtttt tcgggtatga gtgctatgac ttgacaaatg ctaataacat ttgcataatg
    20701 taagtagaga tgaaaactta tgaaaagaga tgatcttatg caaattatta agcgtgatgg
    20761 ccacgttgct gattttgatc cagataaaat ttatcaagca attattaaag cagcaaggac
    20821 ggtctatgtt attgatgaca cgtggcgaca aaacttaaca catgtcacta aaaaagtagt
    20881 tattgattta gaagaagcac atgtagaacg tcctactatc aatatggtcc aatcccttgt
    20941 ggagaatcgt ttgatggatg ctggatatat taccattgca gaacattaca tttcttatcg
    21001 tcttcagcga gatttagagc gcaatggcta tggtgataag attgtggttc acttgcgttt
    21061 tgaacaaata aaataaaaac gcttctaatg gcattttagt gtctttgagg ggataaggtt
    21121 taaataccta acagataaaa atctgttagg tatttttttg ctactattag gtgtattcta
    21181 tattacatag aacttaagca ttcaagcttt aatttaactt tctgtttatt ttttgctaca
    21241 ttttgggaaa ctcccctcct ttcttagttg aggtgaataa acttttattt gataaatcat
    21301 atccttagtc ttaatgaaac agtctaagat aatactactt cgaagtgaca gctagtagtt
    21361 tccaattttt aagtagtcta aaattatgtt tttttaattt caaaaccatg ctttcgtttg
    21421 ttataaaaac cgatcttcca tagttaga
//
LOCUS       DAUDWO010000031        20963 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.031, whole genome shotgun sequence.
ACCESSION   DAUDWO010000031 DAUDWO010000000
VERSION     DAUDWO010000031.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20963)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20963)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20963
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.031"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            146..868
                     /locus_tag="VHC05_001255"
     CDS             146..868
                     /locus_tag="VHC05_001255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEQ5402563.1"
                     /translation="MPKEQPLYLQIVDALEVKIRKSMTANDKLLSERELSDLYGVSRI
                     TIRLALKELELRGLIYKKQGKGTYVSGIKEPATDLSSTYSFTEQMKKMGKMPKTEILS
                     FEQYQVTPYLSGLLELDPDTEVFELERLRIADDMPLMFERSYIPAQPFQGLSIADLKR
                     KALYDIFAKDYQETIRLAEEEFYASIALDYEADLLGIKKGDPVLHIIRKTYNDKNILI
                     EFTFSIARADQFRYRVQHHPNG"
     gene            888..2087
                     /locus_tag="VHC05_001256"
     CDS             888..2087
                     /locus_tag="VHC05_001256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HEQ5402564.1"
                     /translation="MFTKTQEALEALGAAITTKEIKQEPRLWQETMTFFDETRDSLDS
                     FLKRVCKSANGNNVHVIFTGAGTSEYIGNTICPYLKKVGNRQCYLFESVASTDLVAAP
                     DYYLAEEETVLLVSFARSGNSPESVAAVNLVNQLVPNSYHLTITCAKDGELAKKAQQD
                     ERSYLYLMPEDANDAGFAMTGSFTCMMLAALLIFDDANSIAQKEAYVTDMILAGQAVI
                     DQERRLQELADLGFERLVYLGSAGLAKLTQEAQLKMLELTAGQVATVYESSMGFRHGP
                     KSFINDRTLVIGFVNNDAYVRQYDLDMLEEIQADGIALKTLALLQGGDINFSEDQFRL
                     DTRHLLPDAYLAFPMILVAQTLALLTAVTLGNSPDTPSATGMVNRVVKGVTIHPYPTS
                     SRQCNKA"
     gene            complement(2185..2445)
                     /locus_tag="VHC05_001257"
     CDS             complement(2185..2445)
                     /locus_tag="VHC05_001257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018370011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="HEQ5402565.1"
                     /translation="MRKDIHPDYRPVVFLDTTTGYQFLSGSTKASKETVEFEGETYPL
                     IRVEISSDSHPFYTGRQKFTQADGRVDRFNKKYGLKDANAAK"
     gene            complement(2560..3501)
                     /locus_tag="VHC05_001258"
     CDS             complement(2560..3501)
                     /locus_tag="VHC05_001258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional oligoribonuclease/PAP phosphatase
                     NrnA"
                     /protein_id="HEQ5402566.1"
                     /translation="MITTFETILDKIKAHQTIIIHRHQNPDPDALGSQAGLKEIIAQN
                     FPDKKVLMTGFDEPSLAWMSQMDQVTDKDYKEALVIITDTANRPRIDDERYTLGQCLI
                     KIDHHPNDDVYGDFYYVDTSASSASEIIADFAFSQNLTLSDKAAKLLYTGIVGDTGRF
                     LYASTTSKTLSIASQLRHFEFDFAAISRQMDSFPLKIAKLQSYVFEHLTIDESGAAYV
                     LVSQETLKHFDVTLAESSAIVCAPGKIDNVQAWAIFVELTDGNYRVRMRSKEKIINGI
                     AKRHGGGGHPLASGANSANLEENQAIFRELIAVCQEI"
     gene            3895..4344
                     /locus_tag="VHC05_001259"
     CDS             3895..4344
                     /locus_tag="VHC05_001259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HEQ5402567.1"
                     /translation="MALAKIVYASMTGNTEEIADIVANKLQELGHDVDIDECTTVDAS
                     EFENADIAVVATYTYGDGDLPDEIVDFYEDLQDLDLEGKIYGVVGSGDTFYDYFCKSV
                     DDFSEQFALTGAIKGAEPVKVDLAAEDEDIDRLEAFAEQLSQAVNNL"
     gene            4520..4804
                     /locus_tag="VHC05_001260"
     CDS             4520..4804
                     /locus_tag="VHC05_001260"
                     /EC_number="5.4.99.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate mutase"
                     /protein_id="HEQ5402568.1"
                     /translation="MRLEEIRQEINGIDHHLVALLEKRMALVEQVTAYKLANHLPVLD
                     QVRENQILDRVSYLVKDQAFEPAIHETFKTIMSLSRQYQTQHLTGGDIND"
     gene            4797..6059
                     /locus_tag="VHC05_001261"
     CDS             4797..6059
                     /locus_tag="VHC05_001261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="voltage-gated chloride channel family protein"
                     /protein_id="HEQ5402569.1"
                     /translation="MIKSIATLPKPSLKEALGLIGLALPIGVAVGVVDVIFGKGLLFL
                     SEYRDHHLFLLLPFLALAGLVIVFLYDKLGKEVRQGMGLVFQVGHGQKDQIPPILIPL
                     ILFSTWVTHLFGASAGREGVAVQIGATISHYCQRFVTSQEAARHLLIMGMAAGFAGLF
                     QTPIAAVVFALEVLLVGTLRYCALLPSLVAACVASWTSHSLGLEKFTIVLEETLTITP
                     LTLVKLIGLGLIFGLVGNSFACLLGWFKPYLSQKLPNPYLRIAFIGVLLSICLMIGHV
                     GRYSGLGTHLLAAAFSGQTILTYDWLLKMIVTVISLSAGFQGGEVTPLFAIGASLGIV
                     LAPYLGLPVLLVAALGYVTVFGSATNTFWAPIFIGIEVFGPENALAYFVTSAAAYMIS
                     HRHSIYSYQKVVMINLKDMTVNQMDLKK"
     gene            6174..6521
                     /gene="rplS"
                     /locus_tag="VHC05_001262"
     CDS             6174..6521
                     /gene="rplS"
                     /locus_tag="VHC05_001262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L19"
                     /protein_id="HEQ5402570.1"
                     /translation="MNPLIQSLTEGQLRSDIPNFRPGDTVRVHAKVVEGTRERIQIFE
                     GVVISRKGQGISEMYTVRKISGGIGVERTFPIHTPRVDKIEVIRHGKVRRAKLYYLRA
                     LQGKAARIKEIRR"
     gene            6768..6839
                     /locus_tag="VHC05_001263"
     tRNA            6768..6839
                     /locus_tag="VHC05_001263"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:6801..6803,aa:Arg,seq:cct)
     gene            7549..8118
                     /locus_tag="VHC05_001264"
     CDS             7549..8118
                     /locus_tag="VHC05_001264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HEQ5402571.1"
                     /translation="MKGMNYQDYIWDLGGTLLDNYELSTQAFVQTLAFFSLPGDHDAV
                     YQKLKESTAIAVATFAPNEPEFLHVYRLREADKLAQPIWCLGAKEILEKIATSGSRNF
                     LISHRDCQVNQLLEQAGLLIYFTEVVTASNGFARKPNPESLFYLKEKYDINSGLVIGD
                     RLIDKQAGQAAGFNTLLVDGRKNLLEIVT"
     gene            8119..10071
                     /gene="gyrB"
                     /locus_tag="VHC05_001265"
     CDS             8119..10071
                     /gene="gyrB"
                     /locus_tag="VHC05_001265"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="HEQ5402572.1"
                     /translation="MIEENKHFEKKMQEYDASQIQVLEGLEAVRMRPGMYIGSTAKEG
                     LHHLVWEIVDNSIDEALAGFASHIKVFIEADNSITVVDDGRGIPVDIQAKTGRPAVET
                     VFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVRVYKNGQIHYQEFKRGAVV
                     ADLEVIGTTDVTGTTVHFTPDPEIFTETTQFDYNVLAKRIQELAFLNRGLKISITDKR
                     SGMEQEEHFHYEGGIGSYVEFLNDKKDVIFETPIYTDGELEGIAVEVAMQYTTSYQET
                     VMSFANNIHTHEGGTHEQGFRAALTRVINDYAKKNKILKENEDNLTGEDVREGLTAVI
                     SVKHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFQRFLLENPQVARKIVEKGILASKA
                     RIAAKRAREVTRKKSGLEISNLPGKLADCSSNDANQNELFIVEGDSAGGSAKSGRNRE
                     FQAILPIRGKILNVEKATMDKILANEEIRSLFTAMGTGFGADFDVSKARYQKLVIMTD
                     ADVDGAHIRTLLLTLIYRFMRPVLEAGYVYIAQPPIYGVKVGSEIKEYIQPGIDQEDQ
                     LKTALEKYSIGRSKPTVQRYKGLGEMDDHQLWETTMDPENRLMARVTVDDAAEADKVF
                     DMLMGDRVEPRRDFIEENAVYSTLDI"
     gene            10439..12163
                     /gene="ezrA"
                     /locus_tag="VHC05_001266"
     CDS             10439..12163
                     /gene="ezrA"
                     /locus_tag="VHC05_001266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septation ring formation regulator EzrA"
                     /protein_id="HEQ5402573.1"
                     /translation="MSSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQAL
                     FALPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLTVNSFADIENHIFEAENLNDTFN
                     FIRAKHEINSVESQLNLVEEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASIS
                     ENEDNFGSTMPEIDKQMKNIETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITE
                     QIPAIVAKLEDDFPDQLDDLETGYRRLLEENYHFPEKNIEARFQEIRESIRANSSELV
                     TLDLDRAREENTHIQERIDSLYEVFEREIAAYKVAAKNSKMLPRYLAHVKHNNEQLKD
                     EIARLSRKYILSETESLTVKAFEKDIKEIEDSTLAVAEQFGLQEKPFSELQVTFERSI
                     KTLTNVESGQMDVFAAVKDIEKIESQARHNLDVYVTQLHMIKRYMEKRHLPGIPQDFL
                     SAFFTTSSQLEALMDELSRGRINIEAVSRLSEVATVAIANLEDLTYQVVQNATLTEQL
                     LQYSNRYRSFEAGVQSSFEHALRLFEVENDYQASFDEISYALETVEPGVTDRFVNSYE
                     KTREHIRF"
     gene            complement(12295..12753)
                     /locus_tag="VHC05_001267"
     CDS             complement(12295..12753)
                     /locus_tag="VHC05_001267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YueI family protein"
                     /protein_id="HEQ5402574.1"
                     /translation="MTNLEDKLLKGAWGERRLNPEQQRYYLGTYAERVVLSALLDEAQ
                     TKTVKDYLKRELPSLQLVYQPLHLKISSKLAPQLQILYMKLAKENHLPVTIITETHMT
                     SPFAFILHTDHAINLKETRLEVILKQTKNDQLSKQTPEKTKSFWKRFLKK"
     gene            12980..14287
                     /gene="eno"
                     /locus_tag="VHC05_001268"
     CDS             12980..14287
                     /gene="eno"
                     /locus_tag="VHC05_001268"
                     /EC_number="4.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopyruvate hydratase"
                     /protein_id="HEQ5402575.1"
                     /translation="MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTG
                     EHEAVELRDGDKSRYLGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPN
                     KGKLGANAILGVSIAVARAAADYLEVPLYTYLGGFNTKVLPTPMMNIINGGSHSDAPI
                     AFQEFMIMPVGAPTFKEGLRWGAEVFHALKKILKERGLVTAVGDEGGFAPKFEGTEDG
                     VETILKAIEAAGYEAGENGIMIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQV
                     DYLEELVNKYPIITIEDGMDENDWDGWKVLTERLGKRVQLVGDDFFVTNTEYLARGIK
                     ENAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAG
                     QIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLKK"
     gene            complement(14762..15792)
                     /locus_tag="VHC05_001269"
                     /pseudo
     CDS             complement(14762..15792)
                     /locus_tag="VHC05_001269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677767.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(16059..17600)
                     /locus_tag="VHC05_001270"
                     /pseudo
     CDS             complement(16059..17600)
                     /locus_tag="VHC05_001270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284650.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
     gene            18073..>20963
                     /locus_tag="VHC05_001271"
     CDS             18073..>20963
                     /locus_tag="VHC05_001271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1542 domain-containing protein"
                     /protein_id="HEQ5402576.1"
                     /translation="MFLKHQDVKQKNWRMRKVKKLFVSSCMLLTVGLGVAVPTGFSQS
                     NGVMVVKAAEVPAAEGVFKIETDNLQNWEAETNTQGYKGTFSKSPDSQGFYKVQTNSG
                     AGIGVQVAPKGNGRMDIKIGNRVEIPKGYYVGGIRTKTPVLEKDNTYRLSFTTSKTSG
                     TDVEFKTRIKDVEANGDLGQEHTIKFDGNTVSTGNPWIKGLTNKKHTVDFIGKGKALS
                     MAFRFSPFKTTNITYTFTDMNISNVTPASVPETPSSVYEEATKISGKAVASKDNFNKR
                     TNFLGDVVNVYKLDQLVGTAQVKSGNTFEVVLNLKEPLKQGEKLEVEIQNPKSALLSA
                     RVPINVIAKPYDKAQHLKDSKASLDEAYRQTVENITQDNWLKSSEKQKQTNAAKLAYD
                     QGIIELGRSNDKAAINSVVTKYTQKKTGLITKEHILGEKDKVITAAKNAIEEKATAEK
                     TKIDSDNSLTTPEKEAQLAQLSTAKEAALTAITESPDADTVGTKQTEGEASVSGIHQG
                     KDLEAIKTAAKNAIEEKATAEKTKINNDITLTAKDKEQQLKEVETALTKAKDNVKAAK
                     TADAINDARDKGVATIDAVHKAGQDLGARKSGQVAKLEEAAKATKDKISADPTLTSKE
                     KEEQSKAVDAELKKAIEAVNAADTADKVDDALGKGVTDIKNQHKSGKGLDVRKDEHKK
                     ALEAVAKRVTAEIEADPTLTPEVREQQKAEVQKELELATDKIAEAKDADEADKAYGDG
                     VTAIENAHVIGKGIEARKDLAKKDLAEAVAKTKALIIEDKTLTDDQRKEQLSGVDTEY
                     AKGIENIDAAKDAAGVDKAYSDGVRDILAQYKEGQNLDDRRNAAKEFLLKEADKVTKL
                     INDDPTLTHDQKVDQINKVEQAKLDAIKSVDDAQTADAINDALGKGIENINNQYQHGD
                     GVDVRKATAKGDLEKEAAKVKALIAKDPTLTQADKDKQTAAVDAAKNTA"
BASE COUNT         6611 a         3626 c         4400 g         6326 t
ORIGIN      
        1 caaacctaag aaagattagg tttgcttttt gttttctttc ttttattttt gatcaaaaaa
       61 ttttaatatt tctaaatatt tgcttgacta agaattatta ttataatata ctttagatgg
      121 ttataacaag ttagaggtga ataagatgcc aaaagaacaa ccactctatt tacagattgt
      181 tgatgcccta gaagttaaaa tcagaaagag catgacagcg aacgataagt tactgtcaga
      241 acgagaacta agcgaccttt acggtgttag ccgcatcacg attagactag ctcttaaaga
      301 attagaacta cggggcttaa tttataaaaa gcagggcaag ggaacctatg tttctggtat
      361 caaggaaccc gccactgatt tatcaagtac atatagcttt acagagcaga tgaaaaaaat
      421 gggaaaaatg cctaaaacag aaattctttc ctttgaacag tatcaggtaa caccttactt
      481 gtctggtctc ttagagcttg atcccgatac agaagttttt gaattagaac gcctaaggat
      541 tgcagatgat atgcccttga tgtttgaacg atcctatatt cctgctcagc cttttcaggg
      601 gttaagcatt gcggacttga agcgtaaagc tttgtacgat atctttgcaa aggactatca
      661 agagacaatc cgtcttgcag aagaagagtt ttatgccagc attgccttgg actatgaagc
      721 agaccttttg ggaatcaaaa aaggagatcc tgtcttacat attattcgta aaacttataa
      781 cgataaaaat attttgatcg aatttacttt cagtattgca agagcagacc agtttaggta
      841 tagggtacaa catcacccca atggttaaag aaatgggagg ttaatacatg tttacaaaaa
      901 cgcaggaagc tttggaggct cttggtgcag ctatcactac caaggaaatt aaacaagaac
      961 cccgtttatg gcaagaaacc atgacgtttt ttgacgaaac aagagattct ctggattctt
     1021 ttttaaagag agtttgtaaa agcgctaacg gaaataacgt tcatgtcatc tttacaggtg
     1081 cgggtacatc tgagtacatc ggtaatacca tttgccctta cttgaagaag gtggggaatc
     1141 ggcagtgcta tctctttgag agtgttgctt caaccgattt ggttgcggcg ccagattatt
     1201 atcttgctga ggaagagacg gtactattag tctcctttgc taggagtggt aatagtccag
     1261 aaagtgtagc ggctgttaac ctggtcaatc aactagtgcc aaatagttat catttaacca
     1321 ttacgtgtgc caaagatgga gaactggcga aaaaagcaca gcaagatgag cgttcttacc
     1381 tttatttgat gcctgaagac gctaatgatg ctggttttgc catgactggt agttttacct
     1441 gtatgatgct agcggctctt ttgatttttg atgatgctaa cagtatagct cagaaagaag
     1501 cttatgtgac tgatatgatt cttgctgggc aagctgttat tgaccaagaa agacggctac
     1561 aagagctagc tgatttagga tttgaacgtt tagtttatct aggttctgct ggtttagcca
     1621 agttaaccca ggaggctcaa ctaaaaatgc tagaattgac tgctggtcag gttgcaacag
     1681 tttatgagtc ttcgatggga tttaggcatg gtccgaaatc ttttattaat gaccgtacct
     1741 tagtcattgg atttgtcaat aatgatgctt acgtcagaca gtacgatttg gacatgttag
     1801 aggaaatcca agcagatggc attgccctta aaaccttggc tctattgcaa ggaggggata
     1861 tcaacttttc agaggaccaa ttccgactag acacccgtca cttattgcca gacgcttact
     1921 tagcttttcc catgatttta gtcgcgcaga ccttggccct cttaacggcc gttacattag
     1981 gaaattcccc tgacacccca tctgcgacag gaatggttaa tcgtgtggtc aaaggagtaa
     2041 cgattcaccc ttacccgact agtagtcgtc aatgcaacaa agcttaaagc ttttgtgtag
     2101 aagccgtaaa acgaaatgat tttgtgctag taggccaaaa gaaaagaccc tcctgataca
     2161 ggaaggtttt ttgtattatc ttgcttattt tgctgcgttt gcgtctttga gaccgtattt
     2221 tttgttgaag cggtccacac gtccatctgc ttgagtgaac ttttgacgtc ctgtgtagaa
     2281 tgggtgtgaa tctgatgaaa tttccacacg gataagtggg taagtttcac cttcaaactc
     2341 aacagtttct ttagaagctt ttgttgagcc gctaaggaac tggtaacctg tagttgtatc
     2401 taggaaaaca actggacgat aatctggatg aatgtctttt ctcatcttaa aaaattcctt
     2461 tctgccatga tacttgatgc atcatagtta ttaactattc tagtgtaaca aaacttgaat
     2521 gacttgacaa ggcttttctt tccttatttt ttaaaaatcc taaatctctt ggcaaacagc
     2581 gatgagttct cggaaaatag cttgattttc ttctaaatta gctgagttgg ctccgctagc
     2641 aaggggatgc ccccctccac cgtgacgctt agcaatgcca ttaataatct tttctttact
     2701 gcgcatacgc acacggtagt tgccgtcagt taactcaaca aaaatagccc aagcttgaac
     2761 gttatcaatt ttaccaggag cacagacaat ggcagagctt tctgctaggg tcacgtcaaa
     2821 atgttttaag gtttcttggc tgacaaggac ataagcagcc ccactctcat caattgttaa
     2881 atgctcaaag acgtagcttt gcagctttgc tattttcaaa ggaaacgaat ccatttgcct
     2941 tgaaatcgca gcaaagtcga actcgaaatg tctgagttgg ctagcaatgg aaagggtttt
     3001 actagtggtt gaggcataaa gaaatcgccc tgtatcacca acgataccag tgtataagag
     3061 cttagcagcc ttgtcagaga gagtaagatt ctgactaaag gcaaagtctg caatgatttc
     3121 acttgcgcta gaagcgcttg tgtccacata atagaagtca ccatacacat catcgttggg
     3181 atggtgatca atcttaatta agcactgccc cagtgtgtag cgctcatcat caatccttgg
     3241 tcgattcgct gtatctgtaa tgatgaccaa agcctcttta tagtctttat cagtcacctg
     3301 atccatttgg ctcatccaag ctaaactagg ctcatcaaaa ccagtcatta aaaccttttt
     3361 atctgggaaa ttttgtgcaa taatttcttt caagccggcc tgactaccaa gagcatcagg
     3421 gtcaggattt tgatggcgat ggataataat agtttggtga gcttttattt tatctaaaat
     3481 tgtttcaaaa gttgttatca tgctttaatc tttctttttc aaaaagagga aaataaccgt
     3541 ttaacatagt cttcaaaaaa cggtttgtgt cataaggagg tgtgcgttat gttaagtggc
     3601 taatgctaga attttttaag attgtcaaag accataaatt gacattttat ctgaaaatca
     3661 tatcctattt tattatagca taaaagtaag ctctagataa tggtaaatta atctaggaaa
     3721 aaaagaggtt agttatcagt tatgatacta tcaaagctag tcttgcaaat gcaagtgaaa
     3781 aaatagtttt taagtgtttt aagtaatcat atcaaccttc tcgttaaaca attagtgctt
     3841 ttcctaaaaa agtgtgctaa aataaacata gtttagtaat tttgggagga atttatggca
     3901 ttagcaaaaa tcgtttatgc cagcatgacg ggaaatactg aagaaatcgc tgatatcgtt
     3961 gcaaataaat tgcaagaatt gggccatgat gttgacattg atgagtgcac aacagttgac
     4021 gcttcagagt ttgagaatgc tgatatcgct gtcgttgcga cttatactta tggtgatggt
     4081 gacttaccag atgaaatcgt tgatttttac gaagatttac aagatttaga cttagaaggt
     4141 aaaatctatg gcgttgtcgg ctctggtgac actttttatg actatttttg caaatctgtt
     4201 gatgactttt cagagcaatt tgcgcttact ggtgccatca aaggtgcaga gcctgtcaaa
     4261 gtagacttgg cagcagaaga tgaagacatc gatcgtttag aggcctttgc agagcaactc
     4321 tcacaggctg ttaataatct ataaaactat ttagtaaaaa tgtcagggac ttccttggca
     4381 tttttagatt tttaacctaa aataaaggga atgtcacttc agggtaggaa ttgaaaaaaa
     4441 caattagctt caccttgctt ctgatcctct tattaactat aataaaaaga taatctaata
     4501 catctagaaa aggaaagtta tgcgtttaga agagatacga caagaaatca atggtattga
     4561 tcaccacttg gttgccttat tagaaaagcg gatggcactt gtagagcaag taacagctta
     4621 taaactagcc aatcacttgc ctgtcttaga tcaggtgcgg gaaaatcaga tcctagatag
     4681 ggtttcttat ctcgttaaag accaagcatt tgagccagct atccatgaga cgtttaaaac
     4741 cattatgtct ctttcacggc agtatcaaac gcaacactta acaggtggtg acattaatga
     4801 ttaaatcaat tgcaacactg cctaaaccct ccttaaaaga agcgttagga ctaataggtt
     4861 tggcgcttcc cataggggtc gcggttggag tggttgatgt gatttttggt aaagggcttt
     4921 tgtttctttc cgagtatcgc gatcaccacc ttttcttgct tcttcctttt cttgccctag
     4981 caggtcttgt tatcgttttt ctttacgata agttaggcaa agaggttcgt caagggatgg
     5041 gattggtttt tcaggtaggg catggtcaaa aagatcagat tcctcctatt ctcattcctc
     5101 ttattttgtt ctcgacttgg gtaacccact tatttggagc gagtgcgggt cgagaagggg
     5161 tagccgttca aataggagct accatctctc attattgtca gagatttgtg actagtcaag
     5221 aagccgcacg acacctttta attatgggga tggcagccgg ttttgcagga ctttttcaaa
     5281 cgccgattgc tgctgtcgta tttgccctcg aggttttatt ggtaggaacg cttcgctact
     5341 gcgctttatt accttcctta gttgctgctt gcgtggcttc ttggacctct cattctttgg
     5401 gattagagaa atttacgatt gttcttgaag aaacattgac cataactccc ttaaccttag
     5461 ttaaattaat tgggttaggt cttatttttg gtctggtggg aaatagtttt gcctgtttac
     5521 ttggctggtt taaaccttac ctgagtcaaa agctaccaaa tccttatctc aggattgctt
     5581 tcattggtgt tttgttatct atctgtttga tgattggtca cgttggaaga tatagtggtc
     5641 tagggactca tttgcttgcg gcagcttttt ctggccaaac tatcctaact tacgactggc
     5701 ttttaaaaat gatcgtgacg gtgattagct tatctgcagg ctttcaaggt ggtgaagtga
     5761 cgcctctatt tgctattgga gcttctttag gtatcgtttt ggccccttac ttaggtcttc
     5821 ctgtactgtt ggttgctgca cttggttatg tcacggtatt tggaagtgca acaaatacct
     5881 tttgggcccc tatctttatt gggatagagg tctttggtcc agagaatgcc ctagcatatt
     5941 ttgtcacctc ggctgcagcc tatatgatta gtcacagaca ttccatttac agttatcaaa
     6001 aagtagtcat gatcaattta aaagacatga cggtaaatca gatggattta aaaaaatagc
     6061 tttacaataa agaagctttt tgttagaata aatctcgtgt gtaatggaca cacgaaaatt
     6121 acggctaatc cgctaagaca agtacttaag attagtaaga taggagaata aaaatgaatc
     6181 cattaatcca aagtttgaca gaaggtcaac ttcgctctga tatccctaac ttccgtcctg
     6241 gtgacactgt tcgcgttcac gcaaaagttg tcgaaggaac tcgcgaacgt atccagatct
     6301 ttgaaggtgt tgttatttca cgtaaaggtc aagggatctc agaaatgtac actgttcgta
     6361 aaatctcagg tggtatcggg gtagagcgta cattcccaat ccacacacca cgtgttgaca
     6421 aaatcgaagt tatccgccac ggtaaagtcc gtcgtgcgaa actttactac ttgcgtgcat
     6481 tacaaggtaa agctgctcgt atcaaagaaa ttcgtcgtta gtttgaaccg aaacgtaacg
     6541 gaatagaata aaaagactag agtctctagt ctttttatgt cgtcgtgaca atgtgataat
     6601 cggtgattaa cgctatgctc gtaggacact ttgaaagttc cttagcagtt ataattagta
     6661 tattgtaata acaaaatgaa gcaaaataaa ctttcagtta tctgatattt catcttgcat
     6721 taccttattt tctaggttaa aatagaagac aaggtgaata taagatagac cccttagttc
     6781 aatggatata ataactccct cctaaggagt agttgctggt tcgattccgg caggggtcat
     6841 tattgtcact gaaaaagcct ttacatcaaa ggcttttttc tatgtactca attaatgtta
     6901 ggagcacaaa agaggcagtt cgattattaa ccaattcctc cctatttaca gttgtatggc
     6961 tataaatgga caatcttaag ttagggtctg agtgactaaa cctgtcccta accgcttttg
     7021 gtggtaattc tttttcagct aaaagcgaaa tgttcgagtg tttgaataag tgagtatggt
     7081 aatcaccata aatttttagg cgcttattga tgtgtgcatt taaaattggt aaaccttttg
     7141 aatatggaaa gctgttagca ctctgcttgt gattaatcta tcgtatgtta aaagtgacat
     7201 ttaaattaaa tcatttttta tacatatatt tcaacaggta tttcaacagg atttatcata
     7261 ttggaaaata gcggtgattc tattggtatt ttactattga caggaatttc cctgcctttt
     7321 gtctcctaaa gaagatcagc tttgatctct aacttgatta gagtgggctt ggtactgttt
     7381 atgaattatc agtacatact ttctggagat caaaaaggaa aggaacagct aaagaggtgt
     7441 atgtgttacc attagaggaa tagaacatcg caagactcgt ttattcagtc attacgatac
     7501 ctgttttatt taggaaataa ctataatatt aagtgaattt gtgatataat gaaaggtatg
     7561 aattatcaag attatatatg ggatttggga ggtaccttac tcgataatta cgagctttca
     7621 acccaagctt ttgtccaaac gctagctttt ttcagccttc caggagatca cgatgctgtt
     7681 taccaaaaat taaaagaatc aaccgctatc gctgtggcaa cgtttgctcc taatgagcca
     7741 gaatttttgc atgtgtatag gctaagagaa gcagacaaat tggcacaacc catttggtgt
     7801 ttgggagcta aagaaatttt ggaaaagata gcgacttcag gttcgcgaaa ttttttaatt
     7861 tctcatcgag attgtcaggt gaaccaactt ttagagcaag ctgggttgct aatctatttt
     7921 acagaagtcg tgacagcttc aaatggcttt gctcggaaac caaatcctga aagtttgttt
     7981 tatttaaaag aaaagtatga tattaatagt ggattagtaa ttggagatcg gctaattgat
     8041 aaacaagcag gacaagcagc gggttttaat accttgcttg ttgacggtag aaaaaaccta
     8101 ttggagatag taacgtagat gattgaagaa aataaacatt ttgaaaaaaa aatgcaagaa
     8161 tacgatgcca gtcaaattca ggttctagaa gggctggagg ctgtccgcat gcgtccaggg
     8221 atgtatattg gctcgacagc taaagagggt ttgcatcatt tagtctggga aattgttgac
     8281 aactcaattg acgaagcatt agcaggtttt gcctctcata ttaaagtctt tattgaagca
     8341 gataattcca ttacagtagt agatgatggc cgtggaattc cagttgacat ccaagccaag
     8401 acaggacgtc ccgccgttga aacagttttt acagtcttac acgcaggtgg taaatttggc
     8461 ggaggcggct ataaggtttc tggaggattg catggtgtag ggtcatctgt tgttaatgct
     8521 ttatcaacac aattagatgt gcgtgtttat aaaaacggcc aaattcatta ccaagaattt
     8581 aaacgcgggg cagttgtagc agatcttgag gtcattggaa ccactgatgt gactggaaca
     8641 acggtacact ttacacccga tccagaaatt tttaccgaaa cgactcagtt tgattacaat
     8701 gttttagcaa aacgtattca agagttagcc tttttgaatc gtggtttaaa aatttccatt
     8761 acagataagc gctcaggtat ggaacaagaa gaacatttcc attatgaagg tggaattggt
     8821 tcttatgttg aatttttaaa tgataaaaaa gatgttatct ttgaaacgcc catctataca
     8881 gatggtgaat tagaaggtat tgcagttgaa gtagccatgc aatacacgac tagctatcaa
     8941 gaaacagtca tgagttttgc taataatatt catactcatg aaggtggaac gcatgaacaa
     9001 ggctttagag cggctcttac tcgggtcatc aatgactacg ctaagaaaaa taaaattctt
     9061 aaagaaaatg aggacaattt gacaggagaa gatgttcgtg aaggtttgac ggcggtaatt
     9121 tctgttaagc atccaaatcc tcaatttgaa ggtcaaacca aaacaaaatt gggcaactca
     9181 gaagtggtta agatcactaa tcgtctcttt agtgaggcct ttcaacgttt tcttttggaa
     9241 aacccacaag ttgctcgtaa gattgtggaa aaagggattt tggcttctaa agctagaatt
     9301 gcagctaagc gagcccgcga agtcacccgc aaaaaatcag gcttagaaat ttcaaactta
     9361 cctggaaaat tagcagactg ttcgtcaaat gatgctaacc aaaacgaact tttcatcgtc
     9421 gaaggagatt cagcgggtgg gtcggccaaa tcaggtcgta accgagagtt tcaagctatc
     9481 ttgcctattc gcggtaaaat tttgaacgtg gaaaaagcaa ctatggataa gattcttgcc
     9541 aacgaagaaa ttagaagtct ctttaccgct atgggtacag gttttggtgc agactttgac
     9601 gtgtcaaaag ctcgctacca aaagctggtt atcatgaccg atgccgatgt ggatggcgct
     9661 catattagaa ccttgctttt aactttgatt taccgcttta tgaggcctgt tctagaagct
     9721 ggctatgttt acatcgccca gccacctatt tatggtgtta aggtcggtag tgagattaaa
     9781 gagtatattc agccaggtat tgatcaagaa gaccaattaa aaacagctct tgaaaaatat
     9841 agtattggtc gttcaaaacc aactgttcaa cgttataaag gtcttgggga aatggatgac
     9901 catcaacttt gggaaactac tatggatcct gaaaatcgtt tgatggcgcg tgtgacagtt
     9961 gatgatgccg cagaagcaga taaagtattt gatatgttaa tgggagatcg tgttgaacca
    10021 agacgtgatt tcattgagga aaatgcggtt tatagtacac tggatattta gtcacctttt
    10081 tagtttcaca aggaatctgc taccaaagag gacgaattga ctaaaaatca tgatgcatga
    10141 tgccaacagc tttgttagct agtacgtctt catcttgagg gacagcgtta atgcataggt
    10201 attgagatcg tcccttaata cctatgttag tccttattaa gaaagccttg tgagtcgctg
    10261 gtacgagatt gttgaattag tcaaatatat tttgaaatgc attttaaagt atgttataat
    10321 cgtaatgtta tagtgtattt taaataaaat tttaataaaa ggcgattgag gaatttcagt
    10381 ttttagttat tactggaaca atgttgataa atcgtgtcta aataataagg agattcagat
    10441 gtcaagcgga attatcttgc tgattgtggc tatagtccta ctagtgatta tcgcctatct
    10501 agtgggtgtc atcatacgaa agcgtaatga ttccctaatt accagtctag aagaacgaaa
    10561 acaggccttg tttgctttgc ctgttaatga tgaaattgaa gaagtaaagt cacttcattt
    10621 gataggacag agccaaacct cttttcggga atggaatcag aaatgggtag acttaactgt
    10681 aaattcgttt gcagatattg aaaatcatat ttttgaagct gaaaatttga atgatacgtt
    10741 taattttatt cgcgccaagc atgagattaa tagcgttgaa agtcagctta atcttgttga
    10801 agaagatatc gcttctattc gtgaagcact taatatctta aaagagcaag aagaaaaaaa
    10861 tagtgctcgt gtcacccatg ctcttgattt atatgaaaag ctccaagctt ctatttctga
    10921 gaatgaagat aattttggtt caactatgcc tgaaattgac aaacagatga aaaacattga
    10981 aactgaattt tcacagtttg tcgcactcaa ctcatcaggt gatcctgtag aagcttctga
    11041 agttctggat agagcagaag agcatactat tgctctaggg cagattacag agcagattcc
    11101 agctattgtc gccaagttgg aagatgattt tccagatcag ttagatgatt tggaaacagg
    11161 atatcgccgt ttacttgaag aaaactatca ttttccagaa aaaaacattg aggcacgttt
    11221 tcaggagatt cgtgagtcta ttcgtgccaa ttcatcagag ttagttacac ttgacttgga
    11281 tcgtgctaga gaagaaaaca cgcatattca agaacgcatt gattctcttt atgaagtctt
    11341 tgagcgcgaa attgccgctt ataaggtagc tgctaaaaat agtaagatgc tacctcgtta
    11401 cctagcacat gtgaaacata ataatgaaca actcaaagat gaaattgcac gtttatcacg
    11461 taaatatatt ctaagtgaaa cggaaagtct gactgttaag gcatttgaga aggatattaa
    11521 agagatcgaa gacagtacac ttgctgttgc agaacaattt ggtttacaag aaaaaccatt
    11581 ttcagaactg caagtgactt ttgaacgcag tataaagacg cttactaatg tcgagtcagg
    11641 tcaaatggat gtttttgcag cagttaaaga tattgaaaaa attgaatcac aggcacgcca
    11701 taaccttgat gtttatgtta ctcagcttca tatgattaaa cgttatatgg aaaaacgtca
    11761 cttgcctgga attccacaag actttcttag tgctttcttt acaacgagtt cacagttgga
    11821 agctttgatg gatgagctta gtagaggacg gatcaatatt gaggcagtgt cacgtttgtc
    11881 ggaagttgcg acggttgcta ttgctaatct agaagattta acctatcaag tggttcaaaa
    11941 tgctaccttg actgaacaat tactacaata ttctaatcgc tatcgttctt ttgaagcagg
    12001 agttcaaagt agttttgaac atgctttgag acttttcgaa gtagaaaatg attatcaggc
    12061 ttcttttgat gaaatttctt atgctcttga aacagttgaa cccggggtaa cagatcggtt
    12121 tgttaactct tatgaaaaaa cacgagagca cattcgtttt tgatacttga aagtcgtgat
    12181 attctcacga ctttttatta gctttttgga ccaatacgtg tttttgacta gaatcttctt
    12241 tttaatgatc aaacgaagaa gtagtaacag tgttttttgc tattgagggg atagttattt
    12301 tttcaaaaat cttttccaaa aggatttggt tttttcagga gtttgtttgc taagttgatc
    12361 gttttttgtc tgctttaaga tgacttctaa acgtgtttcc ttcagattta ttgcgtggtc
    12421 ggtatgaagg ataaacgcaa aaggtgaagt catatgcgtt tctgtaataa tagtaacagg
    12481 taaatggttt tcttttgcta atttcatata gagtatttga agttgaggtg ccagcttgga
    12541 agagattttt aagtgtaaag gttgatagac taactgaagg ctcggtaatt ctcttttcaa
    12601 atagtctttt actgttttag tttgagcttc gtctaataaa gcacttaaaa cgactcgttc
    12661 agcatacgtt cctagatagt agcgttgctg ctcaggattt aatcttcttt ctccccaggc
    12721 tccttttaat agcttatctt ctaaattagt catagatacc ctcgcttctt tataatagtt
    12781 tctttattat atcgatttct acaataaaat accaatttga aaattttcgg taaatgtgtt
    12841 gaaaaacaag aaagaaagtg atttttcttg caaaaaacaa aggaagcttt tcatgagatt
    12901 gctttttaag ttgattaaag gcctagtttg tggtattatg aacatgtaaa atattaaaac
    12961 tcataaggag agtattacaa tgtcaattat tactgatgta tacgctcgcg aagtccttga
    13021 ctcacgcggt aacccaacac ttgaagtaga agtttataca gaatcaggtg cattcggacg
    13081 tggtatggtt ccttcaggag cttcaactgg tgaacatgaa gccgttgaac ttcgtgatgg
    13141 tgacaaatct cgttaccttg gtctaggtac tcaaaaagca gttgataacg ttaataacat
    13201 tatcgctgag gcaatcatcg gttacgatgt tcgcgatcaa caagctatcg accgtgcaat
    13261 gatcgctctt gacggtactc ctaacaaagg taaacttggt gctaatgcta ttcttggtgt
    13321 ttctatcgct gttgctcgtg cagctgctga ctatcttgaa gtgccacttt acacttacct
    13381 tggcggattc aacactaaag ttcttccaac tcctatgatg aacatcatca acggtggatc
    13441 acactcagat gccccaattg cattccaaga gttcatgatc atgccagttg gtgcacctac
    13501 tttcaaagaa ggtcttcgtt ggggtgctga agttttccac gctcttaaga aaattcttaa
    13561 agaacgcgga cttgttacag ctgtaggtga cgaaggtgga tttgctccta aatttgaagg
    13621 aactgaagac ggtgtagaaa ctatccttaa agctattgaa gcagctggtt acgaagctgg
    13681 tgaaaacggc attatgatcg gttttgactg tgcatcatca gaattctacg acaaagaacg
    13741 taaagtttac gactacacta aatttgaagg tgaaggcgct gctgttcgta catctgcaga
    13801 acaagttgat taccttgaag agttggttaa caaataccca attattacta tcgaagatgg
    13861 tatggatgaa aacgactggg atggttggaa agttcttact gaacgcctag gcaaacgtgt
    13921 tcaattggtt ggtgacgact tcttcgttac aaacactgaa taccttgctc gtggtatcaa
    13981 agaaaatgca gctaactcaa tccttatcaa agttaaccaa atcggtactt tgactgaaac
    14041 gtttgaagct atcgaaatgg ctaaagaagc tggatatact gccgttgtat cacaccgttc
    14101 aggtgaaact gaagattcaa caatcgctga tatcgcagtt gcaacaaacg ctggccaaat
    14161 caaaacaggt tcattgtcac gtacagaccg tattgctaaa tacaaccaat tgcttcgtat
    14221 cgaagatcaa cttggtgaag ttgctcaata caaaggtatc aaatcattct ataacttaaa
    14281 aaaatagacg gtaagacaga aatcggtcat tcgtagaatg cgatttcgtc gtcgcacctc
    14341 cgtcaggctg actaggttgg tcacgacaaa aggagtgaac atccagtcag ctacgacgca
    14401 aaagttaaag aatagaaagc ttgggaaaat cccaagcttt ttgctttcta aatagtgaaa
    14461 atttactgtg ggctaattta tcctgagcta atgtattagc gaggtaaagt tattgaggaa
    14521 ggcttggatt tgtactgcct ccaaaaagtt ggacactata ttttaaatac agaactaagt
    14581 ccttttatac taattgtcaa gcacatcaag gttttaactg aaaaaatgtt ttagacaata
    14641 gcctaggttt agctgttgtc ttacttgttg tgctctgatt agcataaaaa agtgtacaag
    14701 aaaaaaacct tgcctagtat ttttaagatc aaggtgttac aatgatagag caacaacgac
    14761 tttaatgatt ttgggtcgaa gcgtaattgt aaagtttgtt atgcgttatg aggtaaagca
    14821 ttgtcctgac aaggcaatgt ctagaggcaa tcgtatgtgg cttggttgaa gctgtttacg
    14881 attgcctttt tcgtttctca tagaagtctg cgatatgaca aggattggta tgactagcag
    14941 aagcaatgtc atggatacac ttgaaaagaa tctttggagc ataaggattc ccacgttcgg
    15001 taatgtgctc ttgagctaga cagttgccag actcataatg tctaaagtca atcccaatga
    15061 aagcattaat ttgattagca gattgaaaac aacgaatagc accgagttcg ccaataatac
    15121 ttgttgcagt tgtttctgcg atacttggaa tagagcgtag aatcttgtct tctggtaaag
    15181 gttgagccaa cgccaccatc ttatcaaaaa tagcttgacg acgttcagaa agtctaagta
    15241 attctttggc atagtagcga acctcttcta tcatcggaga ggttttcgta acagtaaaat
    15301 aagactgctt ggctaatgag acaagttttt ccactaagta gatcccacgc ttgtcagaga
    15361 tacgtttaga ggtagattga cggatgatag ctgacaatgc tttgtcagct agctccagta
    15421 caaagctatt acatgaaaaa agccgttacc acattccagt attactcacc agttggtgca
    15481 aataagatgt gttccagttc aggaaaagtg acttgtaaga tcttctgaag gcgattctta
    15541 actctcgaac aatattatcc tcagtcaagt tttgatagaa gcgactcaag tcacgtagca
    15601 gctgataaac ttcttcctga acgtaagttg gttttctaac tagaataaat tgagactgag
    15661 ccaatttttc agtgtctaac ttatccgctt tacgcacccg tagactatct agttttctaa
    15721 aggattgagt tgtgtataag cgtagccatt tttctcaagg aaggactgaa gccgacgaga
    15781 atagactcct gttgtgatgg tctccctttt gccttttaaa caatagtata gccgtttttc
    15841 aaaatgttat taatgatttt ttcctttatt ccagaagaat aagtctgata ctgtttctta
    15901 ttaataatct caatgcccta acaatccatc agtcgaacgg tatttctcaa attactgcag
    15961 ttgactcttg cgttcagttc cctcaccttg tggatgccgt ttagaacaat attagcttgc
    16021 tgagcctttt ggtaatgtga acaaagcatc tttatcactc aaggagaaga caggttcttg
    16081 tggtaagtgt ccaacaaggt cacgataaac tcatcgtacc gtttttggcg gaagtctaga
    16141 aataccttat gaatgtaagc ctcagaaacg tctctaaaac taaacaagaa atacaagaac
    16201 aaatgccctt gattctggta caaatgctgt atcaggttca ggtattgcct atctgcgata
    16261 atgacactct gtttttcctt aacaatatct ttgaaaggaa tgatttcgac attgacaggc
    16321 ataaccgttg caatagctgg cgggaagtaa atcgagagtg cattggtcat caaatccagc
    16381 gcagcagtgt tattggtcaa aagatagaca ggtattggtg gcaaatatgt ttttaggagt
    16441 tcctctaact gtatcgtgaa gagcagtaaa tgataggacg gcagtttccc cacgatgcct
    16501 tctgcgctca tccattcctc aacgatggtt tttagagtat tgtagaagct cttgtttcgt
    16561 ttttgctgtc ttctgaggta atggaacaag tgtatatcag gtaacaaaac ttgaagatta
    16621 ctgataaaga gacgtgagaa ggaaaccaaa atccgtttga aaggaaggga gtttaggata
    16681 ttatcgccta gtagtggacg cagggatgct ttcaaggttt ttccatttgt ttttgtcatc
    16741 accaactcaa acaattcttt cactttttta ggtgtccatt tatccttatg gaaaggatta
    16801 ttggtggtgc aaaaacataa gaaaatataa tccaaatcct catcagttaa atcaggatgg
    16861 taccattttc cgatgatttc ctgactggtc attttgatat cgtgatagat agacagtttt
    16921 ttcaagtgtt tgaatgcatc tgtctgaggg atccccaagt taccatgttg ccgtttccat
    16981 ataagggata tcagaatggc aaagtatgaa aattaataag gggctttact ggcatcatta
    17041 agtgtgatgg cttgattgga gtttataatc agcgaaacca ctttattcat tgatgtttta
    17101 tcaaaatcat aaatggtcat accaaactga tagtgcaaca aggcgatcag aaagcggata
    17161 cggtattctg gtccaacaac atggttttgc cgaacgttta aacctacctt tttcaagtat
    17221 ttccgacaat tggtcctgat acggtaagcg gtggcttggg aaatatactc tcgtttaatg
    17281 aagtcgtgta ggctcagctc tcctggttca attaaaaaac ataacatctt taagaatatc
    17341 gaggtttgat agagtttttt aaaataaggc attttaagtt ggtaggtctt ataggggata
    17401 gaaacagtgt cgtcacaaat ggttaaggtg agggtgtctt ctaaatcctt aatcatttca
    17461 atgagtaagt tgtagacacg ttgttttttg agttcggttt cctgacacaa ctggtctatg
    17521 gagacttcgg aaacgtctaa caaaatgttg agcagtgata atttatcttg taatttggtt
    17581 tctagatgaa ggtgtaatat aactgaactc ctttcatttt tatagcagaa actcgtattt
    17641 atttaattat cacataatta aataaaacag tcaaataatt caatggtgac gcgtgtttaa
    17701 ggagtattga gaatgtcaga tataagcaaa atgcagctga atattcttaa ttttaggtat
    17761 gaaaaagcgt cgggattgat aaaaaatcta ttgaattggg taaatttaag ttgatataat
    17821 aagttgatta gaaaaattaa taattcattt aaattctaat cagctgtaac gttccggggc
    17881 gtgttaaact gtctgaacat agaaaataca ggtttctacg gtgactaaag taagttaagg
    17941 aggattcctt aaattctgtg ataggaacgt aaactctcta caagagtaga gcacgtcatc
    18001 agtcagtctg ggtgtctact ggctgacaac gtcaaataag ataggcatga aaaaaataag
    18061 ggggaacaca gaatgttttt aaaacaccaa gatgtgaaac aaaaaaattg gagaatgcgt
    18121 aaggtcaaaa aactctttgt tagttcatgt atgcttttaa cagtcggcct cggagttgcc
    18181 gtacctactg gattcagcca atctaatggc gtgatggtcg taaaggctgc ggaagtgccg
    18241 gcggctgagg gagtttttaa aatagagacc gataacttgc aaaactggga agcagagact
    18301 aatactcaag gttataaagg aactttttca aaatcgccag actctcaagg attttataaa
    18361 gttcaaacca actcaggagc tggtataggt gttcaagttg ctcctaaggg aaatggcaga
    18421 atggacatta agattggtaa tcgagttgaa ataccaaaag gttattatgt tggtggaatc
    18481 agaactaaga cgccagtttt ggaaaaagat aatacttatc gtttatcctt tacgactagt
    18541 aagacttctg gaacagatgt agaattcaaa acgcgtataa aagatgttga ggcaaatggt
    18601 gacttaggcc aagagcatac aatcaaattt gatggtaata cagtatctac aggtaatcct
    18661 tggataaaag gtctaaccaa caaaaaacat actgttgatt ttattggtaa aggaaaagcg
    18721 ttgtcaatgg cttttaggtt ttctcctttt aaaaccacca atataacata tacttttaca
    18781 gatatgaata tttctaatgt gactcctgca tcagtccccg aaacaccttc ttcagtttat
    18841 gaagaggcaa ctaaaatttc tggtaaagca gtggcttcta aagacaattt taataaaaga
    18901 acgaactttt taggtgatgt tgtgaatgtt tataagttgg atcagttagt tggaactgcg
    18961 caagttaaat cgggaaatac ttttgaagtt gttttgaatt taaaagaacc tttgaaacaa
    19021 ggtgaaaaac ttgaagttga aattcagaat cctaaatcag ctttattgag tgcgcgtgta
    19081 ccaatcaacg tgatagcaaa accttatgat aaagcccaac acttaaaaga ttctaaagcg
    19141 agtctagatg aagcttatcg tcaaactgta gaaaatataa ctcaagataa ttggttaaaa
    19201 tcttcagaaa aacaaaaaca aaccaacgct gcaaagttag catatgacca agggattatc
    19261 gaactaggga gaagcaacga taaagctgca attaattctg tggttacaaa atatacgcaa
    19321 aagaaaactg ggctaattac taaagaacat attttaggtg aaaaagataa ggtaattact
    19381 gcagcaaaga atgctattga agaaaaagca acggcagaaa aaacaaaaat tgattctgat
    19441 aacagtttaa caactccgga aaaagaagca cagttagccc agttgtcaac agcaaaagaa
    19501 gcggctttaa ctgctattac agagtctccg gatgcagata ctgtagggac taaacaaacc
    19561 gaaggtgaag cttcagtatc agggattcat caaggtaaag atttagaagc tattaaaact
    19621 gcagcaaaga atgctattga agaaaaagca acggcagaaa aaacaaaaat caataacgat
    19681 atcacattaa cggcaaaaga caaagaacaa caactgaaag aagttgagac agctcttact
    19741 aaagctaaag ataacgtgaa agctgctaag acagcagacg ctatcaatga cgcacgtgat
    19801 aaaggcgtag caacaattga tgccgtccat aaagcaggtc aagacttagg tgctcgtaag
    19861 tcaggtcaag tcgctaaact tgaagaagca gctaaagcaa cgaaagacaa gatttcagct
    19921 gatccaactt tgacaagcaa agaaaaagaa gagcaatcta aagctgttga cgctgaactt
    19981 aagaaagcga tagaagctgt taacgcagct gacacagctg acaaggttga cgatgctctt
    20041 ggtaaaggtg tcacagacat caagaaccaa cacaagtcag gtaaaggtct tgacgttcgt
    20101 aaagatgagc acaagaaagc tcttgaagct gttgctaaac gtgttactgc tgaaattgag
    20161 gctgatccaa ccttaacacc agaagtgaga gaacaacaaa aagcagaggt tcaaaaagag
    20221 cttgaacttg cgactgataa gattgctgaa gctaaagatg cagatgaagc agacaaagct
    20281 tacggtgacg gtgtcacagc gatcgaaaat gcccatgtta ttggtaaagg tatcgaagct
    20341 cgtaaagacc ttgctaagaa agaccttgct gaagctgttg ctaagacaaa agctctcatt
    20401 attgaagaca aaacgcttac tgatgatcaa cgtaaagaac agttatcagg tgttgataca
    20461 gagtatgcta aaggtatcga gaatattgat gcagctaagg atgctgcagg tgttgataaa
    20521 gcatatagtg acggtgttcg tgacatcctg gcacagtaca aagaaggtca aaaccttgat
    20581 gatcgtcgta atgctgccaa agaatttctt cttaaagaag cagacaaagt gacgaaacta
    20641 atcaatgatg atccaacctt gactcatgac caaaaagttg atcaaatcaa caaagttgaa
    20701 caagctaagt tagacgcaat caagtctgtt gatgatgctc aaacagctga tgctatcaat
    20761 gatgctcttg gtaagggtat tgaaaacatc aacaaccaat accaacatgg cgatggcgtt
    20821 gatgttcgta aagcgactgc caaaggcgat cttgaaaaag aagctgctaa agtgaaagct
    20881 cttattgcta aggatccaac cttgactcaa gctgataaag acaaacaaac agcagcggtt
    20941 gacgcagcta agaatacagc aat
//
LOCUS       DAUDWO010000032        20702 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.032, whole genome shotgun sequence.
ACCESSION   DAUDWO010000032 DAUDWO010000000
VERSION     DAUDWO010000032.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20702)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20702)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20702
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.032"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(<1..620)
                     /gene="smeZ"
                     /locus_tag="VHC05_001272"
     CDS             complement(<1..620)
                     /gene="smeZ"
                     /locus_tag="VHC05_001272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="streptococcal mitogenic exotoxin SmeZ"
                     /protein_id="HEQ5402577.1"
                     /translation="MKKTKLIFSFTSIFIAIISRPVFGLEVDNNSLLRNIYSTIVYEY
                     SDTVIDFKTSHNLVTKKLDVRDARDFFINSEMDEYAANDFKAGDKIAVFSVPFDWNYL
                     SEGKVIAYTYGGMTPYQEEPISKNIPVNLWINGKQISVTYNEISTNKTTVTAQEIDLK
                     VRKFLIAQHQLYSSGSSYKSGKLVFHTNDNSDKYSLDLFYVGYRDK"
     gene            complement(869..1375)
                     /locus_tag="VHC05_001273"
     CDS             complement(869..1375)
                     /locus_tag="VHC05_001273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011185008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topology modulation protein"
                     /protein_id="HEQ5402578.1"
                     /translation="MKIAIIGHSGSGKSTLARFLGQHYHCEVFHLDQLHFSSNWQERS
                     DHDMIADLSTCLLKQDWIIEGNYANCLYEERMSEADYIIYVNFSRFHCVYRAFKRYLN
                     YRGKTRPDMADNCQEKFDVAFVKWILLDGRSRNQLKKYQSVVQKYSHKTIVLTNQKQL
                     SHYMNTIN"
     gene            complement(1430..1870)
                     /locus_tag="VHC05_001274"
     CDS             complement(1430..1870)
                     /locus_tag="VHC05_001274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561036.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEQ5402579.1"
                     /translation="MKIIEYKGNYRDDLIFMVLEAKNALRRIPSINPDLLTIETSYLE
                     KGDCFWLAVNEESRVIGSIAYSSIPKTNEVFLHRLFIKPSLKHQGIGSQLLTFAEDYL
                     RKIGKSHVRIHLGQPKEQWFESYRFYPKQGYQFYDDTHLIKKLI"
     gene            complement(2011..2083)
                     /locus_tag="VHC05_001275"
     tRNA            complement(2011..2083)
                     /locus_tag="VHC05_001275"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(2048..2050),aa:Lys,seq:ctt)
     gene            complement(2084..2280)
                     /gene="ssrS"
                     /locus_tag="VHC05_001276"
     ncRNA           complement(2084..2280)
                     /ncRNA_class="other"
                     /gene="ssrS"
                     /locus_tag="VHC05_001276"
                     /product="6S RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00013"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00013"
     gene            complement(2369..3637)
                     /locus_tag="VHC05_001277"
     CDS             complement(2369..3637)
                     /locus_tag="VHC05_001277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000774759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated recombination protein A"
                     /protein_id="HEQ5402580.1"
                     /translation="MPDHLALRMRPKTISEVIGQKHLVGEGKIIRRMVEANRLSSMIL
                     YGPPGIGKTSIASAIAGTTRYAFRTFNATIDSKKRLQEIAEEAKFSGGLVLLLDEIHR
                     LDKTKQDFLLPLLENGTIIMIGATTENPFFSVTPAIRSRVQIFELEPLSNEDIKTAIQ
                     LAISDKERGFPFLVTIDDEALDFIVTATNGDLRSAYNSLDLAVMSTSPNEDSSRHISL
                     ETMENSLQRSYITMDKNGDGHYDVLSALQKSIRGSDVNASLHYAARLVEAGDLPSLAR
                     RLTIIAYEDIGLANPDAQVHTVTALDAAQRIGFPEARILIANVVIDLALSPKSNSAYL
                     AMDAALADLRTSGNLPIPRHLRDGHYAGSKDLGNAKDYLYPHAYPEKWVKQQYLPDKL
                     VGHHYFEANETGKYERALGSNKERIDKLLD"
     gene            complement(3670..4236)
                     /locus_tag="VHC05_001278"
     CDS             complement(3670..4236)
                     /locus_tag="VHC05_001278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="HEQ5402581.1"
                     /translation="MILLIDNYDSFTYNLSQYLSEFDETIVLYNQDPNLYDMAKKANA
                     LVFSPGPGWPKEANQMPKLIQDFYQTKPILGVCLGHQAIAETLGGTLRLAKRVMHGRQ
                     STIETQGPASLFRSLPQEITVMRYHSIVVDQLPKGFSVTARDCDDQEIMAFEHHTLPL
                     FGLQFHPESIGTPDGMTMIANFIAAIPR"
     gene            complement(4269..6026)
                     /gene="pabB"
                     /locus_tag="VHC05_001279"
     CDS             complement(4269..6026)
                     /gene="pabB"
                     /locus_tag="VHC05_001279"
                     /EC_number="2.6.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="HEQ5402582.1"
                     /translation="MHRKTIIDFKELGHRFLFEKTLLELVAKSLDQVGPVIQQVQHYQ
                     ELGYYVVGYLSYEAAAFFDNALQTHNDRLGNEYLAYFTVHKTCQKEDLPLDYDSITIP
                     NQWVSATQKEAYQKAIETIHHEMRQGNTYQVNYTLQLTQELNAADSLAIYNKLVVEQA
                     AGYNAYIAHDDFAVISASPELFFKQEGNQLITRPMKGTTKRGVNTWLDQQEHDWLQTD
                     RKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVEQYSTVWQMTSTIVGDLKADCDL
                     IDILTALFPCGSITGAPKVSTMAIITSLEPNPRGIYCGSIGICLPDGRRFFNVPIRTI
                     QLSHNQATYGVGGGITWQSKWEDEYEEVHQKTTFLYRHKQIFDLKTTAKVEHQKIAFL
                     EQHLNRLKEAATYFAYPYDEKALQKQLSTYLENKNNAAYRLMIRLSKDGKISLSDQPL
                     EPLSADFLTAQLSLQKKDVTASPFTYFKTSYRPHIEQKSYEQLFYNQAGQLLETSIGN
                     LFIQLGRTLYTPPVAVGVLPGLFRQELLATGQAQEKEVTLADLKEASAIFGGNAVRGL
                     YPLNLELTHLDALLAKSQA"
     gene            complement(6211..8184)
                     /locus_tag="VHC05_001280"
     CDS             complement(6211..8184)
                     /locus_tag="VHC05_001280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidase"
                     /protein_id="HEQ5402583.1"
                     /translation="MRYSRRYPSQTRQMLLALLLMTASLQAGAMTTYADEVNTNHQPL
                     TAQVEASKPTAMESVTSPADQTHPISTQEASSPLHPLTTEATPAAQESPITLEDYKAA
                     SASQLAEWARQQRVTGQQLLDFALETIKETNPELNNVISLREPLARQESEQMTDEGQP
                     FYKVPILVKGLGHTVAGSSNTNGLAFLKDKTSSSTSAFVKQLQKAGFIVVGQSSFPEM
                     GWINVTNSNLYGNTHNPWQLDQNPGGSSGGSAAAVASGQVSLASASDGGGSTRIPASW
                     SGLIGLHPTRGILEGNPTSERSNVSHFALTKSMEDTEKLFQFLLKDKAKAQQNPQRLD
                     TSIPIAYSTQTPAGTPISEEAIAAIKEAVAFLQEQGYQTVEVPYPVDGKLMMQYYYTI
                     AASAAPSINFMAQQTLKRPLQKEDVELLSWALYQTGKDLTKEDVNKAWEGIAAMTEQL
                     NQFYQKYPIFLTPTTAYPAPAADYHHIPKDLVAQLSDMSGLSKEEKLDLIYRQWLPAW
                     TLTPFTQLANLTGTPSLSLPTHVTKSGLPLGILVNSGAHNDSLLLQLGQLFEKANRFH
                     ILTAGKKGLPETPAHEHNLSTQSENKQGVAIPVTYQTKGFTTGPTKGQNGLVTLPQTG
                     DGQSKGVLLTSYISLFLGTLFLAGSFWSNKVKD"
     gene            8357..8827
                     /locus_tag="VHC05_001281"
     CDS             8357..8827
                     /locus_tag="VHC05_001281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3013 family protein"
                     /protein_id="HEQ5402584.1"
                     /translation="MAKYGFLSILEEEMDKHFQYDYAMDWDKKNHAVEVTFVLEAQNK
                     EAIKTIDDSGEVTQDDIVFEDYVLFYNPAKSQFDAADYLVTIPFDAKKGFSREFLAYF
                     AQFLNDVAIEGHSDLMDFLADDSKVDFGLEWNAQAFEEGQQGLEEAASYPYPRY"
     gene            8898..9851
                     /locus_tag="VHC05_001282"
     CDS             8898..9851
                     /locus_tag="VHC05_001282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011055040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HEQ5402585.1"
                     /translation="METWQEVTVHVHRDAQEAVSHVLIETGSQGVAIADSADYIGQKD
                     RFGELYPDVEQSDMIAITAYYPSSTNLADVTVTINEQLAELASFGLQVGQVTVDSQEL
                     AEEDWADNWKKYYEPARITHDLTIVPSWTDYDASAGEKVIKLDPGMAFGTGTHPTTKM
                     SLFALEQILRGGETVIDVGTGSGVLSIASSLLGAKTIYAYDLDDVAVRVAQENIDLNQ
                     GTDNIHVAAGDLLKGVSQEADVIVANILADILVLLTDDAYRLVKDQGYLILSGIISEK
                     LDMVLEAAFSAGFFLETHMIQGEWNALVFKKTDDISGVIGG"
     gene            9851..10600
                     /locus_tag="VHC05_001283"
     CDS             9851..10600
                     /locus_tag="VHC05_001283"
                     /EC_number="2.1.1.193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (uracil(1498)-N(3))-methyltransferase"
                     /protein_id="HEQ5402586.1"
                     /translation="MQQYFIKGKAEKKVTITDKDTIKHMFQVMRLADEAEVILVFDDG
                     VKYLAKVTNSMAHELEIIEALPDQVELPVEVTIASGFPKGDKLDTIAQKVTELGASAL
                     WGYPADWSVVKWDGKKLAKKEDKLAKIVLGAAEQSKRNRVPEVHLFEHKAEFLKSLSS
                     FDHIFIGYEETAKAGQLATLAREVKEVKPGAKILFIFGPEGGISPAEITQFEAAGVIK
                     VGLGPRIMRAETAPLYALSALSYALELQASK"
     gene            10958..13144
                     /locus_tag="VHC05_001284"
     CDS             10958..13144
                     /locus_tag="VHC05_001284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEQ5402587.1"
                     /translation="MKTSFKQLFRFEFWQKFGKCLMVVIAVMPAAGLMISIGNSIPMI
                     NHDSAFLASLGNIIAQIGWAVIVNLHLLFALAIGGSWAKERAGGAFASGLAFVLINRI
                     TGAFYGVSSAMLADPEAKITSLLGTQMIVKDYFTSVLESPALNTGVFVGIIAGFVGAT
                     AYNKYYNYRKLPEVLTFFNGKRFVPFVVILRSIFVALILVVVWPVIQSGINSFGMWIA
                     SSQDSAPILAPFLYGTLERLLLPFGLHHMLTIPMNYTALGGTYEVMTGAAAGTKVFGQ
                     DPLWLAWVTDLVHLKGSDASAYSHLMDSVTPARFKVGQMIGATGTLMGVALAMYRNVD
                     ADKKHTYKMMFISAAAAVFLTGVTEPLEYLFMFAAMPLYLVYALVQGASFAMADLVNL
                     RVHSFGNIELLTRTPMALKAGLGMDVINFVWVSILFAVIMYFIADMMIKKMHLATAGR
                     LGNYDADILGDHNTQARPTQVADSNSQVVQIINLLGGAGNIDDVDACMTRLRVTVKDP
                     AKIGAEDDWKKAGAMGLIQKGNGVQAVYGPKADILKSDIQDLLDSGAVIPEVNMSQLT
                     SKPTPAKDFKHVTEKVLSVADGMVLPITGVKDQVFAAKMMGDGFAVEPTNGNIYAPVA
                     GLVTSVFPTKHAFGLLTDNGLEVLVHVGLDTVALNGVPFSVKVSEGQRVHAGDLLVVA
                     DLAAIKSAERETTIVVAFTNTAEIQDVTLTSLGAQPAKTKVATVEL"
     gene            13227..14045
                     /locus_tag="VHC05_001285"
     CDS             13227..14045
                     /locus_tag="VHC05_001285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HEQ5402588.1"
                     /translation="MTKVLTLNTHSWMQANTLKKLVALAEHILAEKYDIICLQEINQL
                     IESELATDLPRYQALSGTPSIHKDHFALLLIHYLQKRGQHYYWSWAYNHIGYDIYQEG
                     VAILSKQPIHVSDILVSAMADETNYHTRRSLIAKTTLDGKEVAVVNVHLSWFDKGFLG
                     EWEKLEKELLTLNCPLLLMGDFNNPTDQDGYQVMMGSPLDLQDSHKVADHVFGDHSIV
                     ADIDGWQGNKEALKVDHVFTSKDFIIRSSKITFEGGDAPVVSDHYGLEVTLDWR"
     gene            complement(14440..14922)
                     /gene="nrdI"
                     /locus_tag="VHC05_001286"
     CDS             complement(14440..14922)
                     /gene="nrdI"
                     /locus_tag="VHC05_001286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class Ib ribonucleoside-diphosphate reductase
                     assembly flavoprotein NrdI"
                     /protein_id="HEQ5402589.1"
                     /translation="MPQITLVFISLSGNTLSFVKRLSLYLADNYDYHVKQINIKDLKH
                     ETFPVKEEFVAILPTYLEGGNGVDSGEMEILTTPLGEFIAAHGNAQRCLGIIGSGNKN
                     FNHQYCLTAKQYAKRFGFPLLGDFELRGTPDDISRLAQVIMEASSRHSSNDTQTLPNS
                     "
     gene            15303..16292
                     /locus_tag="VHC05_001287"
     CDS             15303..16292
                     /locus_tag="VHC05_001287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEQ5402590.1"
                     /translation="MLTSKHHNLNKLVWRYGLTSAAAVLLAFGGGASSVKAEGMTSGE
                     RTQKINEIKEFIKKIPKTDQEQFRHRPWYGGDYFKDEDYQKELNKFTEDALKKIVDLI
                     EKGATKGEKGDAGPRGERGPQGPVGPAGKAGAKGAKGDKGEAGAPGKDGAQGPKGDKG
                     ETGERGEKGEAGIQGPQGEAGKDGAPGKDGAPGEKGEKGDRGETGAQGPVGPQGEKGE
                     TGAQGPAGPQGEAGKPGEQGPAGPQGEAGKPGEKAPEKSKEVTPAPEKPADKEANQTP
                     ERRNGNMAKTPVANNHRRLPATGEQANPFFTAAAVAVMTTAGVLAVTKRKENN"
     gene            16544..18763
                     /locus_tag="VHC05_001288"
     CDS             16544..18763
                     /locus_tag="VHC05_001288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019316080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="HEQ5402591.1"
                     /translation="MAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVR
                     KSGEPYIVHPIQVAGILADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGQDARDIV
                     DGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQ
                     ERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALV
                     EAIVSKVKTYTTQQGLFGDVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQS
                     DVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQV
                     AEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFS
                     ERIYVFTPTGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVV
                     EIITNANSFGPSRDWVKLVKTNKARNKIRQFFKNQDKELSVNKGRDLLVSYFQEQGYV
                     ANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKERREEERAKAKA
                     EAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKG
                     RGIAIHRSDCHNIKSQDGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQI
                     LSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTTVVEKIKAVPDVYSVKRTNG"
     gene            18778..19221
                     /locus_tag="VHC05_001289"
     CDS             18778..19221
                     /locus_tag="VHC05_001289"
                     /EC_number="3.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-tyrosyl-tRNA(Tyr) deacylase"
                     /protein_id="HEQ5402592.1"
                     /translation="MKLVLQRVKEASVSIDGKIAGAINQGLLLLVGVGPDDNAEDLAY
                     AVRKIVNMRIFSDADGKMNQSIQDIKGSILSVSQFTLYADTKKGNRPAFTGAAKPDLA
                     SQLYDSFNEQLAEFVPVERGVFGADMQVSLINDGPVTIILDTKCH"
     gene            complement(19319..20641)
                     /gene="ska"
                     /locus_tag="VHC05_001290"
     CDS             complement(19319..20641)
                     /gene="ska"
                     /locus_tag="VHC05_001290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_023611186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="streptokinase"
                     /protein_id="HEQ5402593.1"
                     /translation="MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNIQL
                     VVSVAGTVEGTNQEISLKFFEIDLTSGPAQGGKTEQGLSPKSKPFATNKGAMPHKLEK
                     ADLLKAIQEQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQE
                     FLLSGHVRVRPYQPKAVHNSAERVNVNYEVSFVSETGDLDFTPLLRNQYQLTTLAVGD
                     SLSSQELAAIAQFILSKKYPDYIITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQ
                     AYKANSKTGIVEKTNNTDLISEKYYVLKKGEKPYDPFDRSHLKLFTINYVDVNTNELL
                     KSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMDYTLTGKVEDNHNDTNRIIT
                     VYMGKRPEGENASYHLAYDKDRYTEEEREVYSYLRYTGTPIPDNPNDK"
BASE COUNT         5948 a         4042 c         4833 g         5879 t
ORIGIN      
        1 tctttatctc tatatcctac ataaaaaaga tcgagagaat atttatctga attatcattt
       61 gtatgaaaaa ctaatttacc acttttgtag ctagaaccag aagaatataa ttgatgttgt
      121 gctattaaaa attttctaac ctttagatca atttcttgag ctgtaactgt tgttttgtta
      181 gttgatattt cgttgtaagt aacagagatc tgctttccat taatccataa attaacaggg
      241 atatttttag atattggttc ttcttgataa ggcgtcattc caccataggt atatgctatg
      301 acttttcctt ctgacaagta gttccaatca aatgggacgg agaacacagc tattttatct
      361 ccagctttaa aatcattggc tgcatattcg tccatttcgg agttaataaa aaaatctcta
      421 gcatctctaa catcaagttt cttagtcact aagttatgac tggttttaaa atcaattact
      481 gtatctgaat attcatatac aatcgtacta tagatattcc ttagaaggga attattatct
      541 acttctaatc caaacacagg acgagaaatt attgcaatga atattgaagt aaaagaaaaa
      601 ataagttttg tttttttcat aaatagcctc ttttcaggag ttattatttt attatgtttt
      661 aatataacac tttcaaaaga aataatcatt aacaattttg tagatatact tgctgactat
      721 caaatgaaaa ttgagacatg atactaaaag tggattgacg cttttaatta agccgattag
      781 ttatgaaaca atcaaaaaag cctttaaaca aaggctttca gtctgaatag cccggattat
      841 ccgtggttat tttagttttg cactctaatt agttgatcgt attcatataa tgacttagct
      901 gcttttgatt tgttaagaca atggttttat gagagtattt ttggacaacg gattggtatt
      961 tttttaattg gtttcttgaa cgtccatcta gtagaatcca tttcacaaac gcaacgtcaa
     1021 atttttcctg acagttgtca gccatatcag gacgcgtttt tcccctatag tttaaataac
     1081 gcttaaatgc tcgatagaca caatgaaacc gactgaaatt aacatagata atgtaatcag
     1141 cttcactcat gcgctcttca tagagacaat tggcataatt cccctcaata atccaatctt
     1201 gtttgagcag gcatgttgat aaatcagcta tcatgtcatg atctgaccgt tcttgccagt
     1261 tcgatgagaa gtgtagttgg tctaaatgga atacctcaca atggtaatgt tggcctaaaa
     1321 atcgtgctaa ggttgacttt ccagagccac tatgtccaat gatggcaatt ttcaatggat
     1381 acctcctaaa aatgacgtat gaaatgacta taaagggtat gaaatgtgtt tagattagtt
     1441 tcttgatgag atgcgtgtca tcataaaatt gataaccctg tttaggataa aaccgataag
     1501 actcaaacca ttgttcttta ggttgaccta agtggatacg aacatgactc ttgccgattt
     1561 tccttagata atcttctgca aacgtcagaa gttgactgcc aatgccttga tgttttaagc
     1621 ttggtttgat gaagagacgg tgcaagaaga cctcatttgt tttgggaata gaagaataag
     1681 cgattgagcc aataacacga ctttcttcat tgaccgctag ccaaaaacaa tccccttttt
     1741 ccaaataact tgtttcaatt gtcaaaagat ccgggttaat gctgggaatt ctccttaagg
     1801 cattttttgc ttccaagacc ataaaaatga ggtcatctct gtaatttcct ttgtactcaa
     1861 ttattttcat aacagtctcc accttaatct taagcgcttt aattggtatc ataccataaa
     1921 aaaattactg cggggataaa tgatggaaca aatcctcttc tgacaagcaa aaaaagcctt
     1981 taaacaaagg ttttttcatg tatagttgta taccccctac agggctcgaa cctgtgaccc
     2041 atagattaag agtctactgc tctaccaact gagctaagga ggcaagaatg ctgtattggc
     2101 accggtgatc cacgtttttg tattgagccc gcgcagtata agcaggtggg taacgcgctc
     2161 tttcttggaa gttgcgtccg cgtgaaacgg cttgcagact agaaagagtc tttgtttccc
     2221 gaaaacacaa agaaatagtc ggtcaacact tagatgtgga ttcgtatgcc acagcaatgt
     2281 ttctgtactt ttataatacc actttttaaa attttttcaa gcaaaattat cgatttttga
     2341 aatcggttgc gatttttaaa actggcagtc agtctaagag cttatcaata cgctctttat
     2401 ttgaaccaag tgcgcgttcg tatttaccgg tttcattggc ttcaaaataa tgatgtccta
     2461 ctaatttatc tggtaggtat tgttgtttga cccatttttc agggtaggcg tgtgggtaga
     2521 ggtaatcttt ggcattgcct aggtccttgc tgccagcgta atgcccgtct ctaagatgcc
     2581 ttggaatggg gaggttacct gatgttctca aatcagctaa agctgcatcc atagctaaat
     2641 aagctgaatt tgatttagga gatagagcca aatcaatgac cacgttagcg ataagaatac
     2701 gagcttctgg aaaaccaatg cgttgagcgg catctagtgc ggtgacggta tgaacttggg
     2761 cgtcagggtt ggctaagcca atatcttcgt aagcaataat ggtcaatcgt cttgctaaac
     2821 taggcaagtc tccagcttct actaaacgag cggcgtagtg caggctagca ttgacatcag
     2881 aacctctaat ggatttttgt aaggcagata aaacatcata atgcccgtcc ccgtttttat
     2941 ccatggtaat ataactacgc tgcagactat tttccattgt ctctagacta atatgacggc
     3001 tactatcttc attaggagaa gtagacatga ctgctagatc caaggaatta taagcagatc
     3061 gtaggtctcc atttgtggcg gtaacaatga aatctagcgc ctcatcatca attgtcacta
     3121 aaaaaggaaa tccccgttct ttgtcggaaa ttgctagctg aatggctgtt ttaatatcct
     3181 cgttagaaag tggttccaat tcaaaaatct ggaccctgct tctgatagcg ggtgtcactg
     3241 aaaagaaggg attctcagtg gttgcgccaa tcatgataat ggtgccgttc tcaagtaagg
     3301 gtaaaagaaa atcttgtttt gtcttgtcaa ggcgatgaat ctcgtctagt aataatacca
     3361 agccaccaga aaatttagct tcttccgcaa tttcttggag acgttttttg ctgtcaatgg
     3421 tggcattaaa ggtccgaaag gcatatctag tagtaccagc aatagcagaa gcaatggaag
     3481 ttttaccgat tcctggaggg ccatagagga tcatggacga tagtctattt gcttccacca
     3541 tgcgacggat gattttgcct tcgccaacaa ggtgtttttg tccgatgacc tctgaaatgg
     3601 ttttggggcg cattctgagc gctaaatgat caggcatgta actgtcctcc tttcttttgg
     3661 gggatgagat taacggggaa tggctgcgat gaagttggcg atcatggtca tgccatcagg
     3721 agttccgatg ctttctgggt gaaattgtag cccaaaaagt ggcagggtgt ggtgttcaaa
     3781 ggccatgatt tcttgatcgt cacagtctct agcagttacg ctaaaacctt ttggtaactg
     3841 atccacaacg atagaatggt aacgcatgac ggtgatctct tgtggcaggg agcgaaaaag
     3901 actagcaggg ccttgcgttt caatggtgct ttgtctccca tgcatgacgc gttttgccaa
     3961 gcgtaaggtt cctcctagag tttcagcgat agcttggtgt cccagacaca ctcctaagat
     4021 aggttttgtt tggtaaaagt cttgaatgag ttttggcatt tggttggctt ccttgggcca
     4081 accaggacca ggtgaaaaga ctagagcgtt agcttttttg gccatgtcat ataagtttgg
     4141 gtcttggtta tacaagacaa tcgtctcgtc aaattcactt agatattggg agaggttgta
     4201 ggtaaatgaa tcgtaattat caattaagag tatcataggt tccttaataa caaaagatga
     4261 gtggcagttt aggcttgact cttagctaag agggcatcaa ggtgagtaag ctcaaggttg
     4321 agaggataga ggccacggac agcatttcct ccaaaaatag cgctagcctc ttttaaatca
     4381 gctagtgtca cctctttttc ctgagcttga ccagtagcta gcagctcttg gcgaaaaagt
     4441 cctggtaaaa cacccaccgc cactggtggt gtgtagaggg tccgacccag ctggataaaa
     4501 agattgccga tggacgtttc taataattgc cccgcttggt tatagaatag ctgttcataa
     4561 gatttttgct caatatgagg ccggtagctg gtcttaaagt aggtaaaagg cgaagctgtc
     4621 acgtcctttt tctgtaaaga gagttgagct gtcagaaaat cggctgacaa aggttccaag
     4681 ggttgatcag agaggctaat ctttccatct ttggataaac gaatcatcaa acggtaggca
     4741 gcattattct tattttccaa ataggttgac agttgtttct gcaaagcttt ctcatcgtaa
     4801 gggtaagcaa aataagtggc tgcttcttta aggcgattga ggtgttgctc aaggaaggct
     4861 attttttggt gttccacctt ggcggttgtt ttgaggtcaa agatttgttt gtgccgatag
     4921 agaaaagttg ttttttgatg gacttcttcg tattcgtctt cccacttgct ttgccaagtg
     4981 ataccgcctc cgacaccata agtagcttga ttatgactga gctggatggt tctaatggga
     5041 acattgaaga aacggcgacc gtcaggtaaa caaatgccaa tacttccaca ataaatcccc
     5101 cttgggtttg gctccagaga tgtgataatc gccatggtgg agactttagg agcccctgtg
     5161 atagagccac aaggaaagag agctgtgaga atgtctatca ggtcacagtc cgctttgagg
     5221 tcaccaacaa tggttgaggt catttgccag acggtagagt attgttccac ctcacagagc
     5281 ctatcgacac aaacactgcc tgtttggcaa atttttccca tgtcattgcg gagcaagtca
     5341 acaatcatca tgttttcaga gcgatttttc ctgtcagttt ggagccaatc atgttcttgt
     5401 tgatccagcc aggtgttaac cccgcgctta gtggtaccct tcataggtct ggtgatgagt
     5461 tgattgcctt cctgtttaaa gaacaattca ggactagctg aaataacagc aaagtcatca
     5521 tgggcgatat aggcattgta gccagcagcc tgttcaacga cgagtttatt gtaaatggct
     5581 aagctgtcag ctgcattgag ttcctgagtt aattgaaggg tgtagttaac ctgataagta
     5641 ttgccctgtc gcatctcatg gtgaatggtt tcaatggctt tttgataggc ttctttttga
     5701 gtggcgctga cccattggtt agggatagta atgctgtcat aatcaagagg taggtcttct
     5761 ttctgacagg ttttgtgcac cgtaaaatag gcaagatact cgttgcctaa tcggtcatta
     5821 tgggtttgta aggcgttgtc aaaaaaagca gctgcttcgt aactgaggta gcccaccacg
     5881 tagtacccca gttcttggta gtgctgaacc tgttgaatga ctgggccgac ctgatctaag
     5941 gacttggcta ccaactctag taaggttttt tcaaacaaga agcggtgccc aagctccttg
     6001 aaatcaataa tggtttttct atgcataccc aaattatatc ataaaagcgt ttgccaagcc
     6061 taatgagaac aggcaacaac tgtcttttga ccacgtaaaa agactgaact ttcttagtga
     6121 aagttcagtc ttgattgact acaatatact cttatcgtaa ggcaagcagc agtgaatgtt
     6181 taggtaggtt aaatctccga cgacaatagc ctagtctttt actttattgc tccagaagct
     6241 tcctgctaag aagagggttc caaggaaaag gctgatgtag ctagttaaca acacaccttt
     6301 tgactgacca tcaccagttt gagggagggt tactaagccg ttctggccct tggttggtcc
     6361 agtagtaaat cccttggttt gataagtcac tggaatggca acgccttgtt tgttttcaga
     6421 ttgagttgag aggttatgct catgcgcagg agtttctggc aatccttttt tgccagccgt
     6481 caggatatgg aaacgatttg ctttttcaaa gagctgtccc agttgtaaca ggagactatc
     6541 gttatgagct ccgctattca ccaaaatgcc aagaggtaga ccgcttttcg tcacatgggt
     6601 tggtaaggac aaggatggtg ttcccgtcag gttagcaagc tgggtaaatg gtgttagcgt
     6661 ccatgcaggt aaccattgcc ggtaaataag gtccaatttt tcttctttgc tcaagcctga
     6721 catgtcactg agctgtgcta ctaggtcttt cggaatgtgg tggtaatcgg cagcaggggc
     6781 gggataggct gttgtcggtg ttaagaagat ggggtatttt tggtagaact ggtttaattg
     6841 ctcggtcatg gctgcgatac cctcccaggc tttgttgaca tcctctttgg tcaagtcttt
     6901 cccagtttgg tagagcgccc atgataggag ttcgacatcc tctttttgaa gggggcgttt
     6961 caaggtttgt tgtgccataa aattgataga tggcgctgca gaagcagcaa tagtgtaata
     7021 gtattgcatc atgagcttac catcaacggg gtaaggcact tctacggttt gataaccttg
     7081 ctcctgtaaa aaggctacag cttctttgat cgcagcaata gcttcctcac taattggtgt
     7141 tccagctggt gtctgggtgc tgtaagcaat ggggatactt gtgtctaaac gctgtgggtt
     7201 ttgttgcgct ttagccttgt cttttaagag gaattggaag agcttttcag tgtcttccat
     7261 gctcttagtt agagcaaaat ggctaacatt gctacgttca gaagtcggat ttccctctaa
     7321 aatgccacgt gttgggtgta ggccaatcaa gccactccaa gaagctggaa tgcgggttga
     7381 gcccccacca tcagaagcac tggctagact gacttgtcct gaagccacag cagctgcaga
     7441 gccaccagag gacccgccag gattttggtc aagctgccat gggttatgtg tatttccgta
     7501 aagattggaa ttcgtcacat taatccatcc catttcaggg aaagaggact gccctaccac
     7561 gataaaacca gccttttgga gttgtttgac aaaggcgctg gtagatgagc tggttttgtc
     7621 tttcaaaaag gcaagcccgt tggtgttgct acttccagca acggtgtgtc ctaacccttt
     7681 aaccagaata ggaaccttgt aaaagggttg cccctcatct gtcatttgct cgctctcttg
     7741 tcgagccaat ggttcacgca gagaaatgac attattgagc tcagggttag tttctttgat
     7801 ggtttccaag gcaaaatcta gcagctgttg gcctgtgacc cgttgctggc gagcccactc
     7861 agctaattgg ctcgcactgg ctgccttata gtcttctaag gtaatcggag attcttgggc
     7921 ggcaggagtg gcctctgttg ttaaagggtg taaaggagac gaagcctctt gcgttgagat
     7981 tggatgggtc tggtctgcag gtgaagtgac agattccatg gctgtcggct tactagcttc
     8041 cacttgggcc gttagtggtt gatggttggt attaacctca tccgcataag tagtcatagc
     8101 tccagcttgt aggctggcag tcattaataa caaggcaaga agcatctgtc ttgtctgaga
     8161 agggtagcgt ctagaatatc tcattctttt tctcctaaca tcataatcgc ttattagttt
     8221 aacataatgg gaggaaagta aggggtaaaa cgcttactaa aatacagaag gcccatcagt
     8281 cagcatttgc cagtgaaagt tagctcaaat tatgctacaa tggaagcaaa taatcgttag
     8341 gaaaaaggac aattagatgg caaaatacgg ctttttatca atattagaag aagaaatgga
     8401 taagcatttt cagtatgatt atgctatgga ttgggacaag aaaaatcatg cggttgaagt
     8461 gacttttgtg ttagaagctc aaaataaaga ggccataaaa accattgacg atagtggcga
     8521 agtgacccaa gatgatattg tctttgagga ctatgtgctc ttttacaacc ctgccaagtc
     8581 tcaatttgat gcagcagatt atttggttac tattcctttt gacgctaaaa agggcttttc
     8641 tcgtgaattc ttagcttact ttgcgcaatt tctcaacgat gttgctattg aagggcacag
     8701 cgatttgatg gatttcttag cagatgacag caaggttgat ttcggcttgg aatggaatgc
     8761 gcaagctttt gaagaaggtc aacaaggact agaagaagca gcaagttatc cttacccaag
     8821 gtactaaggt gacacacgag atggtgctaa caccattagg acaataacca aaaggtcaaa
     8881 atagaaagga catacttatg gaaacgtggc aagaagtgac ggttcatgtg catcgtgatg
     8941 cgcaagaggc tgtttcacat gtgttgattg agacaggcag tcaaggggtt gctatcgcgg
     9001 atagcgcaga ctatattggg caaaaggacc gctttgggga gttataccca gatgtggagc
     9061 agtctgacat gatagctatt acagcctatt acccaagtag cactaatttg gcggatgtga
     9121 ccgtgaccat taatgaacag ttagcggagt tagctagttt tgggttacag gttggtcagg
     9181 ttactgtgga tagtcaggaa ttggctgagg aagactgggc agacaattgg aaaaaatact
     9241 atgaaccagc tcgtatcacg catgatttaa ccattgtccc tagttggaca gattatgacg
     9301 cttctgctgg ggaaaaagtg attaaattag atcctggaat ggcatttggg acagggacac
     9361 atcccacaac taagatgagc ctttttgctc tagaacaaat ccttcgtggt ggtgagacag
     9421 ttatcgatgt agggaccgga tcaggtgtcc tctcgattgc cagttcctta ctaggtgcta
     9481 aaaccatcta cgcttatgat ttagatgatg tggctgttcg agtggctcaa gaaaacattg
     9541 atttaaacca aggaacagac aacattcatg tggctgccgg cgacctttta aaaggggtta
     9601 gccaagaagc ggatgtgatt gtagccaata tcttggcgga tatcttagtc ttattgactg
     9661 atgatgctta ccgtttggtc aaggaccaag gctatctcat tttatctggt atcatttctg
     9721 agaaattgga tatggttctg gaagctgcct ttagcgcagg cttcttcctc gagacacaca
     9781 tgattcaagg tgagtggaat gcccttgtct ttaaaaaaac agatgatatc tcaggagtga
     9841 ttggcggcta atgcaacagt attttattaa aggcaaagca gaaaaaaagg taacaattac
     9901 cgataaagat accatcaagc acatgtttca agtgatgcgc ttggctgatg aggctgaagt
     9961 tatcttggtc tttgatgatg gggtgaagta tttagccaag gtgaccaata gtatggctca
    10021 tgagttagag attattgagg ctttgccaga tcaggtggaa ttgcctgttg aggtgactat
    10081 tgcttctgga tttcctaaag gagataagtt agacacgatt gcccagaaag tgactgaatt
    10141 gggagccagt gcgctatggg gctacccagc agactggtca gtggtcaaat gggatggcaa
    10201 aaaattagct aaaaaagaag acaagttggc taaaatcgtt ttaggagcgg ctgagcagag
    10261 caaacgaaat agggtgcctg aagttcacct ttttgaacat aaagcagagt ttctaaaaag
    10321 cctttctagc tttgatcata tcttcattgg ttatgaggaa acagctaaag caggtcagct
    10381 agcgaccttg gcgcgtgaag taaaagaagt taagccaggg gcaaaaatcc tctttatctt
    10441 tggaccagaa gggggaattt ccccagctga aatcactcag tttgaggcag caggtgtcat
    10501 caaggtgggc ttaggccctc gcattatgcg agcagagaca gcgccgctat atgccttaag
    10561 tgctcttagt tatgctttgg aattgcaggc atcaaaataa gtaagctgtt gcttacttta
    10621 gaaagaagag gctaaagaaa cgaacaggca gttcacgatt gtgtcaacgg ccttttttta
    10681 ttgcttcttg tttttttgaa gagcgttgat gggctcatca ccaaaaaagg aaatgggctc
    10741 ttgtcctctt tttggagagt tacactacta tattaatgaa gaaaaatgac taacatctgt
    10801 ctaagagaac gctttacaaa ttgttgcgag gctagtataa taaaggtatc agatcaatgc
    10861 aaacgattgc attgctgagt tgtagtctat atcattgtgt cacaaaagcg ccttaagggc
    10921 agctatggct aaaaggggat aataaaggag agatagaatg aaaacatcat tcaaacaact
    10981 gtttcgtttc gaattttggc aaaaatttgg gaaatgtctt atggtcgtta ttgctgtcat
    11041 gccagcggct ggtttaatga tcagtatcgg aaactctatt ccaatgatta accatgactc
    11101 agcatttttg gcatctctag gcaacattat cgctcagatt ggttgggctg ttattgttaa
    11161 ccttcacttg ctatttgcct tggccattgg tggtagttgg gctaaagaaa gagctggagg
    11221 ggcctttgcc tcaggtcttg cttttgtctt gatcaatcgg ataacaggcg ctttttatgg
    11281 cgtgtctagt gctatgctag ctgatccaga agcaaaaatc acaagcctcc ttggcaccca
    11341 aatgatcgtt aaagattatt tcaccagtgt cttggaatct ccagctttaa acacaggggt
    11401 ttttgttggg attattgcag ggttcgtagg agcaacggcc tataacaaat actataatta
    11461 ccgtaaactt cctgaagttt tgaccttctt taatgggaag cgttttgtac cgtttgtcgt
    11521 tattttacgt tctatttttg tagcccttat tttggttgtt gtttggccgg tgattcagtc
    11581 tgggattaac agttttggga tgtggattgc ctcttcacaa gattcagctc caatcctagc
    11641 cccattccta tatggtacct tggaacgtct cttgttacca tttggtcttc accatatgtt
    11701 gacgatccca atgaactata cagctcttgg tggaacttat gaggtcatga caggtgcagc
    11761 agcgggaaca aaagtatttg gtcaagaccc tttgtggctt gcttgggtaa ctgaccttgt
    11821 tcaccttaaa ggatcagacg cttcagccta tagtcactta atggatagtg tgactccagc
    11881 tcgctttaag gtaggacaaa tgattggagc taccggaaca ttgatggggg ttgccttagc
    11941 catgtaccgt aatgtggatg ctgataaaaa acacacatac aaaatgatgt tcatctcagc
    12001 agcggcagcg gtctttttga caggggtaac tgagccactt gagtacctat ttatgtttgc
    12061 ggcgatgcca ctttaccttg tttatgccct tgtgcaggga gcttcatttg ccatggcaga
    12121 ccttgtgaat ctccgtgttc actcatttgg aaacattgaa ttattgaccc gtacccctat
    12181 ggcccttaaa gcaggtctag gcatggatgt gattaacttt gtttgggtct ctatcctatt
    12241 tgcagtcatc atgtacttta ttgcagatat gatgatcaag aaaatgcatc tcgcaacagc
    12301 tggtcgttta ggcaactacg atgccgatat actgggtgac cataacactc aagcaagacc
    12361 tacccaagta gcagatagca actctcaagt tgtacaaatc attaatctcc ttggtggggc
    12421 aggcaatatt gatgatgttg atgcttgtat gacgcgctta cgagtgacgg tcaaagaccc
    12481 cgctaagatt ggcgctgagg acgattggaa aaaagctggc gctatgggct tgatccaaaa
    12541 aggcaacggt gttcaagcgg tctatgggcc taaagcagat attttgaaat cagatattca
    12601 agatttgctg gactcagggg ctgttattcc agaagtaaat atgtcacagc tcactagcaa
    12661 accgactccc gcaaaagatt ttaaacacgt gacagaaaaa gtgctatcag tggcagacgg
    12721 gatggttctc ccaatcacag gtgtgaaaga ccaggtgttt gcggctaaga tgatgggaga
    12781 tgggtttgcg gttgaaccaa caaatggcaa tatctatgca cccgtagctg gccttgtgac
    12841 cagtgtcttt ccgaccaagc atgcctttgg tttactgaca gataatggtc ttgaagtgct
    12901 ggtgcacgtg ggacttgata ccgtcgcctt aaatggtgtg cctttttcag tcaaagtctc
    12961 agaaggacaa cgggttcatg caggtgacct attagtcgta gcagaccttg ctgctattaa
    13021 atcagcagag cgtgaaacaa ccattgttgt tgcttttacc aacacagcag agatccaaga
    13081 tgtgaccttg acatctttag gagctcagcc tgctaagact aaagtagcta ccgtagaact
    13141 ttaacaaaac atcacgagat agtgataggt aatagccata gctggtttag gccctatggc
    13201 tcttcttgtc ttataaagga ggattaatga ccaaggtatt aacactgaat acccattcgt
    13261 ggatgcaagc caacactctt aaaaaattag ttgctttggc tgagcatatt ttagctgaaa
    13321 aatacgatat catttgcttg caagaaatca atcagttaat cgagagcgag ctggccacag
    13381 atttaccaag atatcaagct ctttcaggga caccaagcat tcataaagac cattttgctc
    13441 ttcttttgat ccattattta caaaaacgag ggcagcacta ttattggtct tgggcttata
    13501 accatattgg ctatgacatt taccaggaag gcgtggcaat cttatcaaaa caacctattc
    13561 atgtttcaga tattctcgtg tcagcgatgg ctgatgaaac aaactaccac accagacgct
    13621 cactcatagc caaaaccacg ttagatggca aagaagtcgc tgttgtcaat gtgcacttgt
    13681 catggtttga caaagggttt ttaggggagt gggagaaatt agaaaaagag ctgctcacac
    13741 taaactgtcc cttgctactt atgggagatt ttaacaatcc aacggatcaa gacggttatc
    13801 aagtgatgat gggtagcccc ctagacctac aagatagcca taaggttgct gaccatgtgt
    13861 ttggtgatca tagcatcgtg gctgatattg atggctggca aggtaacaaa gaagccctca
    13921 aggtggacca tgtctttacc agcaaggact tcatcatccg atcttctaag attacctttg
    13981 aaggcggaga tgcgccagtc gtcagtgacc actatggtct agaagtgaca ctagactggc
    14041 gttagagcat gtgctaacaa gcacaccaca taagagaagc caagacacat aagaaactgc
    14101 gatcgtctag ggggattagg agaacacaaa gaggtctaac cagctcaagg tagagctggt
    14161 tagacctctt tagtcatgtc agtaacccta gaaaaccagg gctttttttg tcaccaacca
    14221 tctgagcttc acagaaagta ccaccaagcg tatagttgcc ttgctaaagt ctgcatgggg
    14281 gtatttctag gagtgcttgg tgtgatccca agccccacga agcaccatgg accacctctt
    14341 caaaggctga gaaatcataa ggcgtggggt aagagacctc tgtagttatt gtcctaaaag
    14401 cgctcttttt taaaacagct atgatcatct atagacggtc tagctgttag gcagtgtctg
    14461 tgtgtcgtta gacgagtgtc tggagctggc ctccatgatg acctgggcta accgcgaaat
    14521 gtcatcagga gtccctcgca gctcaaaatc acctagcagt ggaaagccaa agcgtttggc
    14581 atactgtttg gctgtcaggc aatactgatg gttaaagttt ttgttgcctg aaccaataat
    14641 cccaagacaa cgctgggcgt tgccatgggc agcaataaac tctcccaaag gagtggtgag
    14701 gatctccatc tcaccagagt caacgccatt tccgccttct agataagtgg gtagaatcgc
    14761 cacaaactct tctttgacgg gaaaagtctc gtgcttcaaa tctttaatgt taatctgttt
    14821 gacatggtaa tcataattgt ctgctaaata aagggatagc cgcttgacaa agctaagggt
    14881 gttgccactg aggctaataa aaacaagggt aatctgaggc ataagtgtct ccttttttta
    14941 tcctacaagg tttcttcata agcttaccac aatcaagacc aacaaacaag taaagaagaa
    15001 acctagcggt atccaaccag acaagaaggt acaagcagtc aaaaaaagta acatttcaaa
    15061 aaagagtgac cttaaagaaa ggatccgtat gccctcgact taaaaacgag gcaggtaagt
    15121 gccaaagtgg ccctctgatc tccacaaaag agcgatcagt caaaatctaa aagatgaaca
    15181 acaaaagaga actttacaat cgttttcaca ctctattata atactattat aaataatcag
    15241 gtctagctac catgttattt tatctaaaac acaccatcta ataaagaaag agagaacaac
    15301 atatgttgac atcaaagcac cataatctca acaaactggt ctggcgctac gggctaacct
    15361 cagctgcagc cgtccttcta gcctttggag gcggggcaag cagcgttaag gctgaaggta
    15421 tgacgtctgg agaaagaaca caaaaaatca atgagattaa agaatttata aaaaaaatcc
    15481 caaaaacaga tcaggagcaa tttcggcacc gaccatggta tggtggcgac tactttaaag
    15541 acgaagacta tcagaaggaa ctgaataaat ttacggaaga tgcacttaaa aaaattgtag
    15601 acttgattga aaaaggtgca acaaaaggtg aaaaagggga tgctggtcct agaggcgagc
    15661 gcggcccaca aggtccagta ggcccagcag gtaaagctgg tgctaaaggt gctaaaggtg
    15721 ataagggtga agccggtgcc ccaggtaaag acggcgccca aggacctaaa ggcgacaaag
    15781 gtgaaaccgg tgaacgcggt gaaaaaggcg aagctggaat ccaaggccca caaggtgaag
    15841 ctggtaaaga tggcgctcca ggtaaagacg gagctccagg cgagaagggt gaaaaaggtg
    15901 accgcggtga aaccggagct caaggtccag taggcccaca aggtgaaaaa ggtgaaacgg
    15961 gcgcacaagg cccagcaggc ccacaaggtg aggcaggcaa accaggtgag caaggcccag
    16021 caggcccaca aggtgaagca ggcaaaccag gtgaaaaagc tccagaaaag agcaaagagg
    16081 taactccagc tccagaaaaa cctgctgaca aagaagctaa ccaaacgcca gaacgccgca
    16141 atggcaatat ggctaagaca cctgtagcca acaaccacag acgtctacca gcaactggtg
    16201 agcaagccaa cccattcttt acagcagcag cagtagcagt gatgacaaca gctggtgtcc
    16261 tagccgttac aaaacgcaaa gaaaacaact aatcctctga attgagagac cttactgata
    16321 agcaaacata atggagagag ccccttggtt ctctctattt ttggtcggga gcaggccttt
    16381 ggtatcatgc tcacgcctga gagatcccaa aagatatcaa aagcagctca ctaaccgttt
    16441 tctaagaaaa ggtcacacta agcgctttct tagcagattc tgccttttgc ttttgtgtgt
    16501 aaagtgttaa aatagggaaa agaaatgcta gatgaggaac gaaatggcaa aaataatgaa
    16561 cgtaacagga gaagaagtca ttgccttagc ggccacctat atgaccaagg ctgatgtggc
    16621 ttttgtggca aaggctttag catatgcaac agcggcccat ttctaccaag tgagaaagtc
    16681 aggcgaaccc tatatcgtcc atccgattca ggtggcgggg attctggctg atttgcatct
    16741 ggatgctgtg acagttgcct gtggcttttt acatgatgtc gtagaagata cggatattac
    16801 cttagatgag atcgaagcag actttggcca agatgctcgt gatatcgttg atggtgtcac
    16861 caagttaggt aaagttgagt acaaatctca tgaggagcaa ctcgccgaaa accatcgcaa
    16921 aatgctgatg gctatgtcca aagatattcg cgtgattttg gtgaaattgg ctgaccgcct
    16981 gcataatatg cgcaccctca aacatttgcg caaggacaaa caagagcgta tttcgcgcga
    17041 aaccatggaa atctatgccc ccttggcgca tcgtttgggg attagtcgca tcaaatggga
    17101 actagaagat ttggcttttc gttacctcaa tgaaaccgaa ttttacaaaa tttcccatat
    17161 gatgaaagaa aaacgtcgcg agcgtgaagc tttggtagag gctattgtca gtaaggtcaa
    17221 aacctatacg acacaacaag ggttgtttgg agatgtgtat ggccgaccaa aacacattta
    17281 ttcgatttat cggaaaatgc gggacaaaaa gaaacgattc gatcagattt ttgatctgat
    17341 tgccattcgt tgtgtcatgg aaacgcagag cgatgtctat gctatggttg gctatattca
    17401 cgagctttgg cgtcccatgc caggccgctt caaggattat attgcagctc ctaaagctaa
    17461 tggctaccag tcgattcata ccactgtgta tgggccaaaa ggacctattg agattcaaat
    17521 cagaactaag gacatgcatc aagtggctga gtacggggtt gctgctcact gggcttataa
    17581 aaaaggcgtg cgtggtaagg tcaatcaagc tgagcaagcc gttggcatga actggatcaa
    17641 agagctggta gaattgcaag atgcctcaaa tggtgatgca gtggactttg tggattcggt
    17701 caaagaagac attttttctg agcggattta tgtctttaca ccgacagggg ctgttcagga
    17761 gttgcccaaa gaatcaggtc ctattgattt tgcttatgcg atccatacgc aaatcggtga
    17821 aaaagcaaca ggtgccaagg ttaatggacg tatggttcct ctcactgcca agttaaaaac
    17881 aggagatgtg gttgaaatca tcaccaatgc caattccttt ggccctagtc gagactgggt
    17941 aaaactggtc aaaaccaata aggctcgcaa caaaattcgt cagttcttta aaaatcaaga
    18001 taaggaattg tcagtgaata aaggccgtga tttgttggtg tcttattttc aagagcaggg
    18061 ctacgttgcc aataaatacc ttgacaaaaa acgcattgaa gcgatccttc caaaagtcag
    18121 tgtgaagagc gaagaatcgc tctatgcagc cgttgggttt ggtgacatta gtcctatcag
    18181 tgtctttaac aagttgaccg aaaaagagcg ccgtgaagaa gaaagggcca aggctaaagc
    18241 agaagctgaa gaattggtta agggcggtga ggtcaaacac gaaaacaaag atgtgctcaa
    18301 ggttcgcagt gaaaatgggg tcattatcca aggagcatca ggtctcttga tgcggattgc
    18361 caagtgttgt aatcccgtac ctggtgatcc tattgacggc tacattacca aagggcgtgg
    18421 cattgcgatt cacagatcgg actgtcataa cattaagagt caagatggct accaagaacg
    18481 cttgattgag gtcgagtggg acttggacaa ttcgagtaaa gattatcagg ctgaaattga
    18541 tatctatggg ctcaatcgta gtggcctgct taatgatgtg ctccaaattt tatcaaactc
    18601 aaccaagagc atatcgacag tcaatgctca gccgaccaag gacatgaagt ttgctaatat
    18661 tcacgtgagc tttggcattc caaatctgac gcatctgacc actgttgtcg aaaaaatcaa
    18721 ggcagttcca gatgtttata gcgtgaagcg gaccaatggc taagaaagga taaaaccatg
    18781 aaacttgtct tgcaacgggt caaagaggcc tctgtttcta ttgatgggaa aattgctggc
    18841 gctattaacc aagggttgtt gttgttagta ggtgtgggac cagatgataa tgcagaagat
    18901 ttggcttacg ctgtgcgaaa aatagtcaac atgcgcattt tttcagatgc tgatggcaag
    18961 atgaatcagt ctatccaaga catcaagggc agtatcttat ctgtgtcgca atttaccctt
    19021 tatgctgaca ccaaaaaggg aaaccgtcct gcctttactg gtgctgctaa gccagatttg
    19081 gctagccagt tgtatgatag ctttaatgaa caattggcag agtttgtgcc agttgagcgt
    19141 ggcgtttttg gggcagatat gcaggttagt ctcatcaatg atggaccagt tacgattatt
    19201 ttagacacga aatgtcacta gtctctacaa ctaagaggtt agaaaaaagc aagcaactgt
    19261 tgatagcgtg ttgcttgctt tttttgtcag ttaatctcat cgttttagaa gatcgtggtt
    19321 atttgtcgtt agggttatca ggtataggtg tccctgtata acgcaggtag ctgtaaactt
    19381 ctcgttcttc ttcggtataa cgatctttat cataagctaa atgatagcta gcattctctc
    19441 cttcgggtcg cttgcccata taaacggtta tgatacggtt ggtgtcattg tgattatcct
    19501 ctacttttcc agttaaggta tagtccataa taccaaaagc atcgagattg ttgtagagta
    19561 gtttagcctt atcacgagga tcgtataaat ctctgaagtc taagttacgt tcgctagctg
    19621 ttaagagctg ctcgcttttt agcaattcgt tggtgttgac atcaacgtaa ttgatggtga
    19681 acagtttcaa gtgactgcga tcaaagggat catacggctt ttcccctttt ttaaggacgt
    19741 aatatttctc agagataagg tcagtgttgt tcgttttttc tacaatacct gttttagaat
    19801 tggccttata agcttgttcc cggtctttga tatggtaagt aaactcttga tccattggta
    19861 aaatcgtacg gaaaatgtca ttgtcatgag tgacgattga ggagtcacgt tttgtaatga
    19921 tataatctgg atattttttt gataggataa attgggcaat cgctgctaac tcttgtgatg
    19981 aaagagagtc accaactgcc agtgtggtca attggtattg gtttcttaac aacggtgtaa
    20041 agtctaaatc tcctgtttcg gagacaaagc tcacttcata gttgacgtta acgcgttcag
    20101 ctgagttgtg aacggcttta ggttgatacg gtctaacgcg cacatgcccg cttagcaaaa
    20161 attcttggac aggttgggtc ggcaaggtta ccgaatcatc tcggtcagca aagtagacct
    20221 tgccgtttcg atcagtaatg gttgcatcgc ttgcaaaatc aatgacctca aagtagccgt
    20281 cgttactgtg aacgttagcg atcaattgtt cttgaatagc ctttaataag tcagcttttt
    20341 caagtttatg tggcattgcg cctttatttg tagcaaatgg ttttgatttt ggacttaagc
    20401 cttgctctgt ctttcctccc tgagcaggtc ctgatgttag gtcaatttca aaaaatttaa
    20461 ggctaatttc ttgattcgtc ccctcaacag taccggcaac gctaacaact aattggatgt
    20521 tgttgacaga tggacggtct agcagccatt caggtccagc aatagcttgg acaggcttga
    20581 ctgttccaaa tgttaatgca aacagcagtg caaacatccc aaaagataag taatttttca
    20641 tagaaacctc ctaaaagtta agtttcaatc cccattatta gaataacata ataattttat
    20701 ag
//
LOCUS       DAUDWO010000033        20484 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.033, whole genome shotgun sequence.
ACCESSION   DAUDWO010000033 DAUDWO010000000
VERSION     DAUDWO010000033.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20484)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20484)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20484
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.033"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(37..2028)
                     /gene="uvrB"
                     /locus_tag="VHC05_001291"
     CDS             complement(37..2028)
                     /gene="uvrB"
                     /locus_tag="VHC05_001291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit B"
                     /protein_id="HEQ5402594.1"
                     /translation="MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLG
                     ATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQ
                     PEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYA
                     DSAVSLRPGQEISRDTLLNQLVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFR
                     VEFFGDEIDRICEIESLTGKTIGEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQL
                     QLFESEGKLLEAQRLRQRTEYDIEMLREMGYTSGVENYSRHMDGRSPGEPPYTLLDFF
                     PEDFLIMIDESHMTMGQIKGMYNGDQARKQMLVDYGFRLPSALDNRPLRREEFESHVH
                     QIVYVSATPGEYEMSQTNTIIEQIIRPTGLLDPEIDVRSSMGQMDDLLGEINQRVARD
                     ERTFITTLTKKMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGIFDVLIGIN
                     LLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNVDGHVIMYADKMTDSMQ
                     RAIDETARRREIQIAYNKAHGIVPQTIKKDIRGLISISKTSHNDISKEEMDYESMSRG
                     ERKEAINALQKQMQEAAELLDFELAAQMRDLILELKLMD"
     gene            2220..4394
                     /locus_tag="VHC05_001292"
     CDS             2220..4394
                     /locus_tag="VHC05_001292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HEQ5402595.1"
                     /translation="MTHKIKVLLLAIMSIFLTCNIASAETIAIVSDTAYAPFEFKDSD
                     QIYKGIDVDIINEVAKRQSWDFSMSFPGFDAAVNAVQSGQASALMAGTTITNARKKVF
                     HFSEPYYDTKIVIATRKANAIKKYSDLKGKTVGVKNGTAAQAFLNNYKKKYDYTVKTF
                     DTGDLMYNSLSAGSIAAVMDDEAVIQYAISQNQDIAINMKGEPIGSFGFAVKKGSGYD
                     YLVNDFNTALKAMKADGTYQAIMTKWLGTDDKATTSQATGNPSAKATPIKDSYKIVSD
                     SSFAPFEFQNGKGKYVGIDIELIKAIAKQQGFKIEIANPGFDAALNAVQSSQADGVIA
                     GATITDARKAIFDFSDPYYTSNIILAVKAGKNIKNYEDLDRKTVGAKNGTSSYSWLKE
                     NAPKYGYNVKAFDDGSSMYDSLNSGSVDAIMDDEAVLKYAISQGRRFETPLEGISTGE
                     VGFAVKKGTNPELIEMFNNGLAALKKSGQYDDIIDKYLDSKKAATPSEKGADESTISG
                     LLSNNYKQLLAGLGTTLSLTLISFAIAIIIGIIFGMMAVSPTKSLRLISTAFVDVVRG
                     IPLMIVAAFIFWGVPNLIESMTGHQSPINDFLAATIALSLNGGAYIAEIVRGGIEAVP
                     AGQMEASRSLGLSYGTTMRKVILPQAVKLMLPNFINQFVISLKDTTIVSAIGLVELFQ
                     TGKIIIARNYQSFRMYAILAIIYLIMITLLTRLAKRLEKRLN"
     gene            4394..5134
                     /locus_tag="VHC05_001293"
     CDS             4394..5134
                     /locus_tag="VHC05_001293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003107174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402596.1"
                     /translation="MTELKIDVQDLHKSYGQNEVLKGIDAKFYEGDVVCIIGPSGSGK
                     STFLRTLNLLETITSGKVMVDGFELSDPKTNIDKARENIGMVFQHFNLFPHMTVLENI
                     IFAPVELGKESKEVAKKHGMALLEKVGLSDKADALPGSLSGGQKQRVAIARSLAMNPD
                     IMLFDEPTSALDPEMVGDVLNVMKDLAEQGMTMLIVTHEMGFARQVANRVIFTDGGQF
                     LEDGTPEEIFDHPKHPRLIEFLDKVLNV"
     gene            complement(5282..5434)
                     /locus_tag="VHC05_001294"
     CDS             complement(5282..5434)
                     /locus_tag="VHC05_001294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402597.1"
                     /translation="MTEKNGVTFLMAVGFFLIAISPMVGNKYLHIVTGLALTGLGYYL
                     TKHKRP"
     gene            complement(5431..6810)
                     /locus_tag="VHC05_001295"
     CDS             complement(5431..6810)
                     /locus_tag="VHC05_001295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEQ5402598.1"
                     /translation="MSHFSDKFMEISGKIGSQRHLVAIRDSFISMMPITMAGSVAVLL
                     NVFLRDIPNNMGWTGFAKAMQPVIDINGYVYFGTIGIMALFFAFAFGYNLAVMHKINP
                     LAGGLISFGSFIATLPQTLTISTPLENASANLISNLKEMGLSVVTAGGASSIETSQWG
                     AIALKYVGATGLFTALIIGFLSSFVYAALTKRNITITLPDNVPPAVNKAFAAIIPGTV
                     AIYASAIFAYLIFALTGSSLSDVISTYIQLPLLGLSQGIGSVILLTFLVQLLWFFGLH
                     GHNVLAPVMDGIYMVALTENTAAYNTAHSAANLPYLWTRGSFDAYAQMGGSGVTLALI
                     IAIFIFSKREEHKTIAKLSAPMGVFNINEPITFGMPIVLNPTFVIPWLIVPPICASIA
                     YFATAIGLIPPIFLSVPWITPVGLYAYLATGGNIMAGLVSLFNLFVAFLIWAPFVILA
                     NKEKASDLA"
     gene            complement(6988..7437)
                     /locus_tag="VHC05_001296"
     CDS             complement(6988..7437)
                     /locus_tag="VHC05_001296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015017132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3284 domain-containing protein"
                     /protein_id="HEQ5402599.1"
                     /translation="MIISAEGDVSIHHCFEAMLISLQEDYRQNTLRQLSRDDIKAGIN
                     YVKHYGKYKERTVRVLITALEAPQLYTACFSSNHGIKELAYRLEALGENRTRITYSYD
                     YHPLDIFQKANHFIVGKLFKKSLERQSQAQLAALIQYAKQLQQPSSL"
     gene            complement(7434..7769)
                     /locus_tag="VHC05_001297"
     CDS             complement(7434..7769)
                     /locus_tag="VHC05_001297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEQ5402600.1"
                     /translation="MTEPSNLEAIMGLIMYGGEAKGKAVEAIHAARDGQFEEAQHLLQ
                     EATNSLNIAHKSQTHLLSQEAAGDAVELSLLMVHGQDHMMTALAFIDLAKELVTVYDK
                     MSAIQRGES"
     gene            complement(7772..8083)
                     /locus_tag="VHC05_001298"
     CDS             complement(7772..8083)
                     /locus_tag="VHC05_001298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEQ5402601.1"
                     /translation="MKSIMLVCNAGMSTSVLVTKMQKAAQARDLEVSIWAVPVSEADN
                     EVAANSIDFLLLGPQVKFLLKDFKDKFEPDIKVDAINMADYGLMNGEKVLETALAMME
                     E"
     gene            complement(8106..10100)
                     /locus_tag="VHC05_001299"
     CDS             complement(8106..10100)
                     /locus_tag="VHC05_001299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HEQ5402602.1"
                     /translation="MLSKKELAIITFLIHHKEQFVSSATLAEVIGMSDRTVRKYLKEL
                     ISSLPEHGAHIISKQGRGYCLEIDHSMAFDIFWQESVTSKKRLADVTQVEESVDREDY
                     VLHKFFFEDAVQDFEELCQELYISRTTLKHVLAGIKERIIPYQLELEITHQHIQIRGK
                     EEDIRHFIMDYFFVTSFDNTLSTMVGNTFLEGINFAEIMIIVLDECRDAKLKLSDFVM
                     NNLVLHIALMVQRIRSGCPLELFSIPIAIRQSDEYQVALRILYQVEEVMGIRFPKEEA
                     NYIALHLNVKHSVGKHWQDDNTDEKLQDHLKACIAKISQLTGMTLETDTNLFQGLLAH
                     MMPLTTRLENHIQLTNPLTEEIKSQYPEIFTLTKQTFSDLLVCQNNDVSDDEWAYISL
                     HLMAAIERYSNRHKLRVLVVCATGYGSAMMLKNRLEREFEGRLRIVDVISYYEITEER
                     LKTVDLIISSISLANLMFLTPVITVSVFLSNQDIETIRQFIGEQEGIKKEVSLPSQMS
                     LAKAEQLLTGVFSPNRFLYLDEKISKEDLLLRMIACLDEAGTETFVEDFYHQMVLREN
                     YSPVIYGEVLAFPHPANPMTYSEQVVVAICREPLEWDKAHQAVHFVFLLSPSKGHNHR
                     LKYVSPGLASFVNQVELQQALLEEPNYSKFMTVFTPLIHD"
     gene            complement(10206..11300)
                     /locus_tag="VHC05_001300"
                     /pseudo
     CDS             complement(10206..11300)
                     /locus_tag="VHC05_001300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888821.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF871 domain-containing protein"
     gene            complement(11309..12709)
                     /locus_tag="VHC05_001301"
     CDS             complement(11309..12709)
                     /locus_tag="VHC05_001301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HEQ5402603.1"
                     /translation="MKQRKHRYQFPDGFLWGSSTSGPQSEGTVPGDGKGPSNWDYWFS
                     IESAKFHHQIGPEKTSTFYENYKGDIALLKETGHTIFRTSIQWSRLIPEGVGEVNPKA
                     VTFYREVFQDIIAQGIKLIVNLYHFDLPYALQEKGGWENKATVWAYETYAKTCFELFG
                     DLVNTWITFNEPIVPVECGYLGYYHYPCKVDAKAAVQVAYNTQLASSLAVKACHKLHP
                     DHKISIVLNMTPAYPRSNAPEDVKAARIAELFQTKSFLDPSVLGVYPAELVSILEEAD
                     LLPQYSADELEIIKNNTVDFLGVNYYQPLRVQAPSKSQQEGDPLILDIYFEPYDMPGK
                     KVNPHRGWEIYEPGLYDIALDLKEHYGNIEWLVTENGMGVEGEEAFLADGQIQDDYRI
                     TFIEDHLIQLHKALGEGANCKGYLLWTFIDCWSWLNAYKNRYGLVALDLESQKRTIKK
                     SGYWFKALSESNGFDK"
     gene            12934..13629
                     /locus_tag="VHC05_001302"
     CDS             12934..13629
                     /locus_tag="VHC05_001302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinamide riboside transporter PnuC"
                     /protein_id="HEQ5402604.1"
                     /translation="MAYLNYFTKTEWALWLSSVLAILISAFLFGDQAPLALIASLIGV
                     TSLIFSAKANPIGQGLVIIFSIIYAYLSLRNSYYGELMTYLFMTLPMTIFSLFTWLNH
                     PFEGKKSQVTISRLTPTDRRCLFVFTILVTLIFYGILASIQTAYLLVSTLSIATSFSA
                     VYLSYKRSPYFALAYGLNDLVLILLWMHAAQTDSSQYAVVICFATFLINDSYTFYNWL
                     MLQRYQEKKVKKG"
     gene            complement(13634..13792)
                     /locus_tag="VHC05_001303"
     CDS             complement(13634..13792)
                     /locus_tag="VHC05_001303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012515888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402605.1"
                     /translation="MGDKPISFKDKDGNFVSAADVWNAEKLEELFNLLNPNRRLRLER
                     EKLKKDEA"
     gene            complement(13861..15174)
                     /gene="obgE"
                     /locus_tag="VHC05_001304"
     CDS             complement(13861..15174)
                     /gene="obgE"
                     /locus_tag="VHC05_001304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HEQ5402606.1"
                     /translation="MSMFLDTAKISVQAGRGGDGMVAFRREKYVPNGGPWGGDGGKGG
                     SVIFRVDEGLRTLMDFRYNRKFKAKSGEKGMTKGMHGRGAEDLIVFVPQGTTVRDAET
                     GKVITDLVEHGQEVVIAKGGRGGRGNIRFATPRNPAPEIAENGEPGEERQLELELKIL
                     ADVGLVGFPSVGKSTLLSVVSSAKPKIGAYHFTTIVPNLGMVRTKSGDSFAMADLPGL
                     IEGASQGIGLGTQFLRHIERTRVILHVIDMSANEGRDPYEDYVSINNELETYNLRLME
                     RPQIIVANKMDMPEAQENLKAFKKKLAAQYDEFDDLPMIFPISSLAHQGLENLLEATA
                     ELLAKTDEFLLYDEADLVDEEAYYGFAETEKDFEITRDDDATWVLSGEKLERLFVMTN
                     MERDESIMKFARQLRGMGVDEALRERGAKDGDLVRIGKFEFEFVD"
     gene            complement(15231..15359)
                     /locus_tag="VHC05_001305"
     CDS             complement(15231..15359)
                     /locus_tag="VHC05_001305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002261953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4044 domain-containing protein"
                     /protein_id="HEQ5402607.1"
                     /translation="MAFGENGPRKKTTFEKVTMVVVILMVLVTVGGLIASALSVLM"
     gene            15603..16945
                     /locus_tag="VHC05_001306"
                     /pseudo
     CDS             15603..16945
                     /locus_tag="VHC05_001306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611514.1"
                     /note="programmed frameshift; internal stop; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            complement(17245..18117)
                     /locus_tag="VHC05_001307"
     CDS             complement(17245..18117)
                     /locus_tag="VHC05_001307"
                     /EC_number="2.4.2.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="HEQ5402608.1"
                     /translation="MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV
                     SLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLL
                     TCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY
                     NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGV
                     DIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK
                     SLDFSMKGLTYLDV"
     gene            18341..19651
                     /locus_tag="VHC05_001308"
     CDS             18341..19651
                     /locus_tag="VHC05_001308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SLC13 family permease"
                     /protein_id="HEQ5402609.1"
                     /translation="MIHLIIISAIALAIGIGYRTKINIGLLAIAFSYLIATTLMGLSP
                     KELLHFWPTSLFFTIFSVSLFYNVATTNGTLDVLAQHILYRTRTHPNAIYMILYLIAT
                     LLSALGAGFFTTMAVCCPLAITLCQKADKHPLIGAQAVNWGASGGANLITSGSGIVFQ
                     GLFKQMGWEEQAFSLGNHIFIVSIIYPLIVLLLLSCYIRYSKGRTNSSLTIDQPPVLS
                     KVQRQTTLLMISSMVLVWLFPLLHLIFPNIAWIATYRQTFDIGFVSILMVCLALRLKL
                     GKQEAILAKVPWAIIIMLCGMSLLMSLAVKSGLVTLIGHLITTTIPHFWLPLFFCVIA
                     GVMSLFSSTLSVVAPTLFPIIATISAQSPHIDIRLLTTATIIGALSTNISPFSSAGSL
                     IQLSLPHIEERSLAFKKQILLGVPISLSLALLTIWILMLLASLS"
     gene            19729..20022
                     /locus_tag="VHC05_001309"
     CDS             19729..20022
                     /locus_tag="VHC05_001309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002304910.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEQ5402610.1"
                     /translation="MPRKTFDKAFKLSAVKLILEEEQPVKMVSSTLKIHPNSLYRWIQ
                     EYEKYGESAFPGHGSALRHAQFEIKKLEKENKLLQEELALLKKFQVFLKPNRK"
     gene            20055..20408
                     /locus_tag="VHC05_001310"
     CDS             20055..20408
                     /locus_tag="VHC05_001310"
                     /inference="COORDINATES: protein motif:HMM:NF024673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEQ5402611.1"
                     /translation="MNSHHACQTLQVSRSGFYAYLKRRLSSKHVENEALKEMIKDIFY
                     EHKERYGSVRITQELCRRGIHVNHKRVGRLLHQLGLYAKGSRYQYKYYNRRRSSLTRP
                     NLVNQCFQATGKNKL"
BASE COUNT         6218 a         4356 c         3696 g         6214 t
ORIGIN      
        1 tatgttaata agtataatat aagctttatt caaaacctag tccattaatt taagttctaa
       61 aatcaagtct cgcatttgag ctgccaattc gaaatcaagt aattcagctg cctcttgcat
      121 ttgtttttgc agagcattga tcgcttcttt tcgttctcct cttgacatac tttcataatc
      181 catctcttct tttgatatat cattgtggct tgttttactt atactaataa ggcctctgat
      241 gtcttttttt atagtttgtg gaacgatgcc gtgcgctttg ttatatgcta tttgaatctc
      301 acgacgacga gccgtttcgt caatagcccg ctgcatagaa tctgtcatct tgtccgcata
      361 cataatgaca tgaccatcta cgtttcgagc tgctctaccg atggtctgaa tcaagccgcg
      421 ttcattacgg aggaaaccct ctttatcagc atccaaaatg gctacaagac taacttctgg
      481 cacatcaatc ccttcacgga gcagattgat tccaatcaag acatcaaaaa taccaagtcg
      541 taaatcacga ataatttctg tccgctctaa ggttttaata tcactgtgca tatacttgac
      601 cttgacaccc atctctttta gataatcagt caaatcttct gccatttttt tagttaaggt
      661 tgtgatgaac gtccgttcat cgcgcgctac gcgctggtta atttctccca acaaatcatc
      721 catttgcccc atacttgacc ttacatcaat ttcaggatca agtagcccag tcggacgaat
      781 aatttgctca ataattgtat tagtctgtga catttcgtat tcaccaggcg ttgctgaaac
      841 atagacaatt tggtgcacat gactttcaaa ttcctcgcgt cttaagggac gattatcaag
      901 agctgatggc aatcgaaaac catagtcaac tagcatttgt tttctggctt ggtcaccatt
      961 atacatgcct ttgatttgtc ccattgtcat gtgactttca tcaatcataa ttaaaaaatc
     1021 ttctgggaag aaatctaaca aggtataagg aggttctcct ggtgacctgc catccatatg
     1081 acgggaatag ttttcgactc cgctagtata gcccatttca cgtaacattt caatatcata
     1141 ttccgttctt tggcgtaatc gctgtgcttc tagtagttta ccttcagatt caaataactg
     1201 taactgctct gctaactctg cttgaatttt ggctattgat tgctccatat gctcatcatt
     1261 tgttacaaag tgagtagctg gaaataaaac caaatggtca acttctccaa tagttttccc
     1321 agttaaactt tcgatttcac atatacggtc aatctcatcc ccgaaaaatt ccacccgaaa
     1381 agcatgttca tccctggatg ctggaaagac ctcaacaaca tcgccacgta cacgaaaaca
     1441 gccgcgttga aaatcaatat cattacgctc aaattgaata tctactaatt gatttagcaa
     1501 agtgtcacgt gatatctcct gacctggacg taggctgact gctgaatctg cgtactcttt
     1561 tggcgaacct agtccataaa tacaagatac agaagctacc actatgacat cgttacgctc
     1621 aagtaaagaa gaggtggctg aatggcgaag tttatcgatt tcatcattga ctgaactatc
     1681 tttttcgata taggtgtcgc ttgatgggac atatgcttca ggttggtagt agtcataata
     1741 ggaaacaaag tattccacag cattgtctgg aaaaaattct ttaaattcac catataattg
     1801 tcctgctaag gttttattgt gagctatcac taaggtaggt ttatttactt tactaattac
     1861 ttggctcatg gtgtatgttt ttcccgttcc tgtagcacct aggagaatct gagctttttc
     1921 tccgccctcg atattatcaa ctaggctttc aatagcttgt ggctgatcac cagacggttt
     1981 atactttgat tttagtttaa atggtttatc atcacgttta tcaatcattt tataccctct
     2041 aatagtctta tctcttataa actattttaa catagataag ccagaatcac ctccaataag
     2101 cgtaaaaaac atgtcattta catgttatgt tttatgacat ataaataaca aatttcttgc
     2161 ttaatgttca acattttgtt ataattaacc atatttttta gttttataag gagattagta
     2221 tgacgcacaa aataaaagta ttgctgcttg cgataatgtc tatttttttg acatgcaata
     2281 ttgcaagtgc tgaaactatt gctattgttt cagatacagc ttatgcccca tttgaattta
     2341 aagactcaga tcaaatttac aaaggaattg acgttgatat tattaatgaa gtagccaaac
     2401 gtcaatcttg ggatttcagt atgagtttcc cgggttttga tgcagctgta aatgctgtac
     2461 aatctggtca agcgagtgct ctaatggccg gtacaaccat tacgaatgct cgtaagaaag
     2521 tctttcattt ctcagagcca tattacgata ccaaaattgt cattgcgaca cgtaaagcca
     2581 atgccatcaa aaaatacagt gacttaaaag gaaaaacggt cggtgttaaa aatggaacag
     2641 cggctcaagc ctttttgaat aactataaaa aaaagtatga ttatactgtt aaaacatttg
     2701 acacaggtga tcttatgtat aatagtttat ctgctggttc tattgccgct gttatggatg
     2761 atgaggcggt tatccaatac gcaatcagcc aaaaccaaga tattgctatt aacatgaaag
     2821 gagagcccat tggaagcttt gggtttgctg tcaaaaaggg aagcggatat gattatctag
     2881 ttaatgattt caatacagct cttaaagcta tgaaagctga tggtacctac caagctatca
     2941 tgaccaagtg gttaggcaca gatgataaag ctaccaccag tcaggcaacg ggaaatccat
     3001 ctgccaaagc tacacctata aaggacagtt ataaaattgt ctctgattcg tcttttgcac
     3061 cttttgaatt tcaaaatggt aagggcaaat acgttggtat tgacatagaa ttaatcaaag
     3121 ctattgctaa acaacaaggt ttcaaaattg aaatcgctaa tccaggtttc gatgctgcct
     3181 taaatgctgt gcaatctagc caagcagatg gggtcattgc tggtgcaact attactgacg
     3241 ctcgtaaagc tatctttgat ttttctgatc cttattatac ttctaatatc attttagctg
     3301 ttaaagctgg aaaaaacatc aagaactatg aagacttaga cagaaaaaca gtaggtgcta
     3361 aaaacggcac ttcatcttac tcttggttaa aagaaaacgc tcctaaatat ggttataatg
     3421 tcaaggcatt tgatgatggt tctagcatgt atgatagctt aaattcaggt tctgtagatg
     3481 ctatcatgga tgatgaggcg gttcttaaat acgctatctc tcaaggtcgt cgctttgaaa
     3541 cacctcttga gggcatttct actggtgaag ttggttttgc tgtcaagaaa ggaactaatc
     3601 cagaattaat cgaaatgttc aacaatggct tagctgctct caaaaaatct ggtcagtatg
     3661 atgacattat agataaatac cttgactcta agaaagctgc aactccttct gaaaaaggtg
     3721 ctgatgagtc tactatttca ggcctattat caaataacta caaacaacta ttggcaggac
     3781 ttggaaccac gctcagttta acccttattt catttgctat tgctataatt atcgggatca
     3841 tctttgggat gatggccgtg tcaccaacta aatcacttcg actcatttca acggcctttg
     3901 tggacgttgt tcgagggatt cctttgatga ttgtggctgc cttcattttc tggggagtac
     3961 caaaccttat cgagagtatg accggccacc agtcaccgat taatgatttc ttagctgcta
     4021 caattgcact gtcacttaat ggcggagcct atattgctga aattgttcgc ggtggtatcg
     4081 aagctgttcc agcagggcaa atggaagcta gtcgaagtct tggtttgtct tacggaacca
     4141 cgatgagaaa agtaattctc ccacaagctg tgaaactaat gttacctaac tttatcaacc
     4201 agtttgttat ttcattgaag gatacaacaa tcgtctcagc aattggttta gtggaactct
     4261 tccaaacagg taaaatcatt attgctagaa attaccagtc gttccgtatg tatgctattt
     4321 tagcaattat ttaccttatc atgattacac tcttaacaag acttgcaaaa cgtttagaaa
     4381 agaggcttaa ctaatgacag aattaaaaat tgatgttcaa gatttacaca aatcttatgg
     4441 tcaaaatgaa gtcttaaaag gaattgatgc caaattctac gaaggtgatg tcgtttgtat
     4501 cattggtcct tctggttctg ggaaatcaac ctttctacgt accctcaacc ttctagagac
     4561 gattaccagt ggtaaggtca tggtggacgg ttttgaatta tcagatccta agactaatat
     4621 tgacaaggca cgtgaaaata tcgggatggt attccaacac ttcaaccttt tccctcacat
     4681 gactgttctt gagaatatta tctttgctcc tgttgaatta ggtaaagagt ctaaagaagt
     4741 tgctaaaaag catggcatgg cacttctaga aaaagtcgga ctttctgata aggccgacgc
     4801 cttaccagga agtttatccg gcgggcaaaa acagcgtgtc gccatcgcca gaagtttagc
     4861 aatgaaccca gatattatgc tctttgatga accaacttct gctcttgacc ccgaaatggt
     4921 tggggacgtt ttgaacgtta tgaaagactt ggcagaacaa ggcatgacca tgttaattgt
     4981 tactcacgaa atgggatttg ctcgccaagt agctaaccgt gttatcttta cagacggtgg
     5041 tcaattcttg gaagatggta ctcctgaaga gatttttgat catcctaagc accctcgtct
     5101 cattgaattt ttagacaagg ttttaaacgt ctaatagagc agacaccata ctaacttcca
     5161 aaaaataata aggcaaggaa acctatctcc ttgccttttt tggttactgt tattattcaa
     5221 accagcaaaa tagggatact cttatgactc tctccttcat aagagtgtcc cctatgcttt
     5281 tttatgggcg tttatgttta gtgaggtaat aacctaatcc cgtaagagct agtcccgtca
     5341 ctatgtgtaa gtatttgtta ccaaccatcg gactaatggc aatgagaaaa aagccaacag
     5401 ccattaaaaa agttactcca tttttttctg tcatgcaagg tcactcgctt tttctttatt
     5461 ggccaaaatg acaaatggtg cccagataag gaaggcaaca aagaggttaa acagtgaaac
     5521 caaacctgcc ataatattac ctccagtagc taggtaagca taaagtccaa caggggtaat
     5581 ccaaggtact gataagaata tcggtggaat caaacctatt gcagtagcaa aataagctat
     5641 gctagcacaa attggtggca caattagcca tggaatcaca aaggttggat tcaaaacaat
     5701 tggcatccca aatgtaattg gttcgttgat attgaaaaca cccattggtg cggacaattt
     5761 ggcaatggtt ttatgctctt ctcgttttga gaatatgaag atagcaataa tcaatgccaa
     5821 ggttactcct gaaccaccca tttgagcata agcatcaaag gacccgcgtg tccaaaggta
     5881 tggtaaatta gcagcgctat gcgctgtatt gtaagcagct gtattttctg ttaaagctac
     5941 catataaata ccatccatca ctggggctaa gacattatga ccatgcaagc caaagaacca
     6001 gagcagttga actaagaagg ttaacaagat aactgaacca ataccctgtg ataagcctag
     6061 caatggtaat tggatatagg ttgaaatgac atcacttagg gaagaacctg ttaatgcgaa
     6121 gatgaggtag gcgaaaattg ccgaagcgta aatcgcaact gttcctggaa taatggcagc
     6181 aaaggcttta ttaaccgcag gtggtacatt atctggtaag gtaatggtaa tattacgttt
     6241 ggtcaaagcc gcatacacaa aacttgataa aaagccaata attaaagctg tgaacaagcc
     6301 tgtggcaccg acatacttta gagctattgc tccccattga ctagtttcaa tacttgaagc
     6361 tccacccgca gtaacgactg aaagccccat ttcttttaaa ttgctaatta ggttagcaga
     6421 ggcattttca agtggtgtcg aaatggttaa agtctgaggt agggtggcaa taaatgagcc
     6481 aaaagaaatc aatcctcccg ccaatggatt aatcttatgc ataacagcta aattgtaacc
     6541 gaaagcaaag gcaaaaaaga gcgccatgat accaattgtc ccaaaataaa catagccatt
     6601 gatgtcgata acaggttgca tagcttttgc aaaccctgtc catcccatat tgtttggaat
     6661 atcgcgtaaa aaaacgttca ataagacagc aactgaacct gccatggtaa taggcatcat
     6721 tgaaataaag gaatcacgaa tagctactaa atgccgttgt gacccaattt ttcctgaaat
     6781 ctccataaac ttatcagaaa aatgcgacat aaatcttctc ctctttttat ttttttaatg
     6841 taacaaaggt aaccttaaaa gcagcggtgt ctgcctaaca caattatctc aaaatcatcc
     6901 ttgttaaacg tgatgcttag agataaccgg taatcggctc ttatccaaat gaacccttct
     6961 ctctcattca aggtctatga ataatcttca caaagacgat ggttgctgca actgtttagc
     7021 atattggata agggctgcta actgagcttg agattggcgt tctaggcttt ttttgaacag
     7081 tttgccaaca ataaaatgat ttgctttttg aaaaatatct agaggatgat agtcataaga
     7141 ataggtaatt ctagtccgat tctcccccag agcctctaat cgataagcca attcctttat
     7201 cccatgattg gaactaaaac aagcagtata taattgcgga gcttctaggg ccgtaataag
     7261 caccctcact gtacgctctt tgtatttacc ataatgttta acatagttta tccccgcttt
     7321 gatatcatct cttgacaact gtctcaaggt attttgtcga taatcttctt ggagcgatat
     7381 cagcatggct tcaaaacaat gatgaatgga aacatctcct tctgctgaaa taatcatgac
     7441 tcacctcttt gtattgctga cattttgtcg taaacggtaa ccaattcctt ggctaaatca
     7501 ataaaggcta aggcagtcat catgtgatct tgcccatgca ccatcaataa agacaattca
     7561 accgcatcac cagctgcttc ttgggagagc aaatgtgtct gcgatttatg ggcaatattt
     7621 aacgagtttg tcgcttcttg aagtaagtgc tgagcctcct caaactgccc atctcgtgct
     7681 gcatgaatag cctctacggc cttgcccttg gcttcgcctc catacatgat taagcccata
     7741 atagcttcta agttggatgg ttccgtcatg cctactcctc catcatcgct agggctgttt
     7801 caaggacttt ttcaccgttc ataagaccat aatcagccat gttaatggca tctactttaa
     7861 tatctggttc aaacttatct ttaaaatcct ttagtaagaa tttgacttgt ggacctaaca
     7921 agagaaagtc aatgctatta gcagccactt cgttgtcagc ttcactcaca ggaactgccc
     7981 aaatagaaac ttcaaggtca cgcgcttggg ctgctttttg catcttagtc accaacacac
     8041 tagttgacat accggcatta caaactaaca taatagattt cataaggttt ctccttttaa
     8101 tcgttttaat catgaataag tggggtaaac actgtcatga atttggaata atttggttct
     8161 tctagtaacg cttgctgaag ctccacctga ttgacaaaag atgccaaacc tggtgataca
     8221 tattttaacc tatgattatg ccctttagac ggggataata gaaagacaaa atgaacagct
     8281 tgatgcgcct tgtcccactc aagaggctct cggcaaatag ccactactac ctgttcagaa
     8341 taagtcatgg gattagcagg atgcggaaag gcaagcactt ctccatagat gactgggctg
     8401 taattttccc tcagtaccat ttgatgatag aagtcctcta caaacgtttc tgttcccgcc
     8461 tcgtcaagac aagcaatcat ccgtaaaagc aagtcttcct ttgagatttt ctcgtctaaa
     8521 taaagaaaac gattagggct aaaaacacct gttagaagct gctctgcttt tgctaaactc
     8581 atctgtgacg gtaaactgac ctctttcttg ataccttctt gttctccaat aaattgtcga
     8641 atagtttcaa tatcctgatt tgacaaaaaa acactgacag taatcactgg tgttaaaaac
     8701 atcagattgg caaggctgat agaggaaata atcaaatcaa cggttttcag tcgctcttcg
     8761 gttatttcat agtaactgat aacatcgaca atacgcaaac gtccttcaaa ttccctttcc
     8821 aagcgatttt tcaacatcat ggcactacca taacctgtgg cacaaactac tagaaccctc
     8881 aatttatgac ggtttgaata acgctcaatg gccgccatta aatgcaaact aatataagcc
     8941 cattcatcat ctgagacatc attattttga catacaagca aatccgaaaa ggtctgcttg
     9001 gtaagggtaa atatttcagg atactggctt ttaatttcct cagttaaagg attagtcagc
     9061 tgaatatggt tttcaagacg tgtggtcaag ggcatcatgt gggctaataa accttgaaat
     9121 aaattagtat ctgtttctaa agtcatgcct gtcaattgac taatcttggc aatacatgct
     9181 tttaaatggt cctgcaactt ttcatcggta ttatcatctt gccaatgctt accaacagaa
     9241 tgtttgacat ttagatgcag tgcaatataa ttagcctcct ctttaggaaa acgtatcccc
     9301 atcacttctt ccacttgata caaaatgcgc agagctactt gatactcatc agactgacga
     9361 atagctattg gaatggaaaa cagttctaat ggacaccccg atcgaatacg ctgaaccatt
     9421 agggcaatat gcaagactag attattcatg acaaaatcag aaagtttcaa cttagcatcc
     9481 cgacattcat ccaagacaat aatcatgatt tctgcaaaat taataccttc aagaaaggta
     9541 ttacctacca tggtggacaa ggtattatca aaactagtaa caaaaaaata gtccatgata
     9601 aaatgcctaa tgtcctcttc tttacctctt atttgaatat gttggtgagt tatttcaagc
     9661 tctaactggt aaggtattat gcgctcctta atgcctgcta aaacatgttt taaagttgtc
     9721 cgactgatat acaattcttg acaaagctct tcaaaatcct gaacggcatc ttcaaaaaag
     9781 aatttatgaa gcacataatc ttctcgatca accgattctt ccacttgagt cacatctgcc
     9841 aaacgttttt tagacgtcac actttcttgc caaaagatgt caaatgccat agaatggtca
     9901 atttctaagc agtaacctcg accttgttta gaaatgatgt gagctccgtg ttcaggaagg
     9961 ctactaatca gttctttgag gtatttccta accgtacggt cactcatacc aataacctca
    10021 gccagagttg cactagagac aaactgctct ttgtgatgga ttagaaatgt tatgatggcc
    10081 agttcttttt ttgataacat tagtcctcct tactacttta gaaaacgctt tctaccctct
    10141 tttagtgtac caaatatttc ctgaaaaagg tgaccatcat tttccacatt gattgtgaaa
    10201 agaatctatg atgggtcaat ctccaaacaa aattcctgcc aaggtcgcaa atcatctaac
    10261 aaactaagat agtcctctct gacctcagca accacattag cttttgaact aatcgtaaaa
    10321 tttttcaaag caatttgcag ttctccctta tatcgatgat agcggtcatt gtcaataata
    10381 atgctacctc gtttgacctc cttagattgg tctcttggag caatctattc ctgagcatag
    10441 actagacgtg gcatggttga tcgaatcaca taatcagata catcgccacg ataacaatgc
    10501 ggatagccaa tgatttgctc ctcaacttct gtcaaatcga tgataggcct aaccttgatc
    10561 gttgtgactg gtcttgctaa agcctgagta catgctgcca attcttcttc cgaaatgaat
    10621 tggttagata tgaggatatt atcaatggtt cctatcgctt tcattaattc tacttgcagg
    10681 ccaatgggca agtgcctatg gtcttccact gtcggcaagc cttctgccag tagccaaggg
    10741 ccttcagatg ctgactgagc ggtaataaaa gcagccgttt caatatcatg ctcatgataa
    10801 aaacgtgaca tatccttaaa atgttgccat gacaaaccgg taaattcatg tggataaaaa
    10861 ttatggcaac caataatatt gctccgttct gcatctgtcg ctagcaatga catcaataat
    10921 tgtttatcag tgctcatatt aagttcaatt ttaagcccaa agggatttct tgttaaagtt
    10981 acaatctctg ctagagggag agcctcgtct aagcgtaagc ccgctaaccc gaaggcatga
    11041 gctcgttcaa taagctgatc tgaccaacca gcttggctaa taaagcttgg actaacgtca
    11101 gcaatcactc gaatgcctaa ttgatttgca taagcaatga gctctgcgta gcaatgaaac
    11161 atctggtgat cagctggtgc cagctgtaag agactcataa acaagcgctt ggctccatag
    11221 ctatgacata agtcaatata agctttactc ttggtaacat cataccgctc agggtataga
    11281 gaaaatccta aatcaaccat attgcctcct atttatcaaa accatttgac tcgctcaacg
    11341 ccttaaacca gtaacctgat ttttttatgg ttcgcttttg actctctaaa tccaaagcta
    11401 ccaaaccata tcggttttta taagcattta accaagacca gcaatcaata aaagtccaca
    11461 agaggtagcc tttgcagttg gctccttctc ccaaagcctt atgaagctgg ataagatgat
    11521 cctcgataaa ggtgatgcgg tagtcatctt gtatctggcc atctgctaaa aaagcttctt
    11581 caccttcgac acccatacca ttttccgtga ctagccattc gatgttacca tagtgttctt
    11641 ttaaatcaag ggcaatatca taaagtcctg gttcataaat ttcccaaccc cggtgaggat
    11701 tgactttttt accaggcata tcataaggtt caaaataaat atctaagata agggggtccc
    11761 cctcttgctg tgacttacta ggtgcctgaa cccgcaaagg ctgataataa ttaactccca
    11821 aaaaatcaac agtattgttt ttgataatct ctaattcatc agcactatat tgaggtaata
    11881 aatcagcttc ctctaaaatg gaaactaact ctgctgggta cacacccaaa actgatggat
    11941 ctaggaaaga tttggtttgg aaaagctctg cgattctagc agccttgaca tcttcaggag
    12001 cattactccg aggataagca ggtgtcatgt taagcacaat actaatcttg tggtcgggat
    12061 gaagcttatg acaagctttg accgccagtg aactggccag ttgtgtgttg taagccactt
    12121 gaactgctgc cttggcatct actttacaag ggtagtgata ataacctaaa tagccacatt
    12181 cgactggaac aatcggctca ttaaaggtaa tccaagtgtt tactaaatca ccaaaaagct
    12241 caaaacaggt ttttgcgtag gtttcataag cccagacagt agctttgttt tcccagccac
    12301 ctttttcttg caaggcatag gggagatcaa aatgatagag gttaacaatc aatttaatac
    12361 cttgagcaat aatgtcttga aatacttctc ggtaaaatgt caccgccttt ggattaacct
    12421 ccccgactcc ttctggaatc aatcgagacc actggattga ggtccgaaaa atcgtgtggc
    12481 ctgtttcttt caaaagggca atgtcaccct tatagttttc ataaaaggtt gaggtttttt
    12541 ctggaccaat ttggtgatga aacttagctg actcaatact aaaccagtaa tcccagttgc
    12601 taggtccttt gccatctcca ggaaccgttc cttcgctttg aggcccagat gtggaacttc
    12661 cccataaaaa gccatctgga aattggtaac ggtgttttct ttgtttcata tcttttgtcc
    12721 tttctttgct cacttctctt tctattataa gaagaaaaac aggtaatgta aacgctttaa
    12781 aaaatctgtt ttttccttat catcacggaa aataagtgat ttaaagcttg acatatttta
    12841 ttatcttaaa gagcctatct aacctgccct gctacttctt atcaaaacca agcccctatt
    12901 gacagatgcc ttagcctatg tttgaatagg ggtatggctt atttaaacta ctttacaaaa
    12961 accgagtggg cactttggtt aagctctgtc ttggccattt taattagcgc ctttttattt
    13021 ggtgaccaag ctcccttagc tttaatagct tctttgattg gtgtgacctc tctcattttt
    13081 agtgctaaag ctaatcctat tggtcaaggg ctcgtcatta ttttttccat tatctatgcc
    13141 tatctttcat tacgaaacag ttactatgga gagttaatga cttatctttt catgaccctc
    13201 cctatgacta ttttttcact ttttacttgg ttaaaccatc cttttgaagg gaaaaaatca
    13261 caagtgacta tttcacgatt aacacccact gatcgaagat gtcttttcgt ttttactata
    13321 ctggtcactc ttattttcta cggcatcttg gcttctattc aaacagccta tttacttgtc
    13381 tccactttat cgattgccac ttctttttca gccgtttatc tcagttataa gcgtagccct
    13441 tattttgctt tagcatacgg gctcaatgat ctagtcctca ttctcttatg gatgcatgct
    13501 gctcaaacag attctagcca atatgcagta gtcatctgct ttgccacctt tcttattaat
    13561 gatagttaca ctttttataa ttggctaatg ctccaacgtt accaagaaaa aaaggtcaaa
    13621 aaaggatgag ggcctaagcc tcatcctttt tcaatttttc acgttctaag cgcaaacgtc
    13681 tattgggatt taaaagatta aacaattctt ctaatttctc agcattccaa acatctgctg
    13741 ccgatacaaa atttccatcc ttatccttaa aggatatcgg tttatcaccc ataatcagaa
    13801 acctccatct taaaggtaaa acacaaggtt gctatggcaa tgccatttct aaagaccaca
    13861 ttaatccaca aattcaaatt caaatttgcc aatacgaaca agatccccgt cttttgctcc
    13921 acgttcacga agggcttcgt caacccccat accgcgcaat tgacgggcaa atttcatgat
    13981 ggattcgtca cgttccatat tggtcatgac aaagagacgt tccaatttct caccagacaa
    14041 gacccaagta gcatcatcat ctcgggtaat ctcaaagtct ttttcagttt ctgcaaagcc
    14101 atagtaagct tcttcatcca ccagatcagc ttcatcatat aataagaatt cgtctgtttt
    14161 agcaagtaat tctgccgttg cttctaacaa gttctctaag ccttgatgtg ctaggcttga
    14221 aatagggaaa atcattggca aatcatcaaa ctcgtcatat tgggcagcca attttttctt
    14281 gaaggctttc aagttttctt gagcctctgg catgtccatt ttattagcca caataatctg
    14341 tgggcgctcc atcaatcgca aattataggt ttccagctcg ttattaatgg aaacataatc
    14401 ttcgtaagga tcacgaccct cattagcaga catgtcaatc acatgaagaa taacccgtgt
    14461 ccgctcgata tgacggagga attgagttcc caaaccaatc ccttggctag caccttcaat
    14521 caaacctggc agatctgcca tagcaaagct atcacctgac tttgtacgaa ccattccaag
    14581 attaggaaca atagtggtaa aatgataggc accaattttc ggtttagctg atgacacaac
    14641 acttaacaaa gttgatttcc caacagatgg gaatccgacc aagccaacgt cagctaagat
    14701 tttgagttct aactctaact gacgttcctc acctggctca ccattttcag caatctctgg
    14761 cgcaggatta cgaggagttg caaaacgaat attcccacgg ccaccacgac cacccttagc
    14821 aatgaccact tcttgaccat gttctactaa gtctgtaatt acttttccag tttcagcatc
    14881 acgaaccgtt gtcccttgag gaacaaagac aatcaaatct tctgcaccac ggccgtgcat
    14941 gcctttggtc ataccttttt caccagattt cgccttgaat ttacgattat accggaaatc
    15001 catcaaggta cgcaaacctt cgtccactcg gaagataact gagccacctt taccgccgtc
    15061 tcctccccaa ggaccgccat ttgggacgta cttttcacga cgaaaagcta ccataccatc
    15121 gccaccacgg cctgcttgga cactgatttt tgccgtatct aaaaacatac tcatactttt
    15181 tttattctct aactttcttt tactttaaaa aaacgccttt cagcgtttcc ttacattaat
    15241 actgataggg cactcgcaat aagcccgcca acagttacaa gaaccattag gataacaacg
    15301 accattgtca ctttttcaaa ggttgttttt ttgcgaggtc cattttctcc aaatgccacg
    15361 ttaaatacct catctattga tttttcttct tatatcttaa catgaaagat cgttttaggc
    15421 aaatatcaga tgaatattta cgctatgtag actattactg agtattgtat cttgtgaatt
    15481 tcatatgaat atgatacatt agcatttgca aaataatgtt acagataaaa acctcctcgt
    15541 ctggactgaa ctgcacccca aaagttagac acaaaatcta acgattgggg tggtattttt
    15601 ttatgaaatt taatcaagaa acgaaagtta agatttatga gttacggcaa atgggagagt
    15661 ccattaaatc catatcaaaa aagtttgata tggcagaatc cgatgtcaaa tatatgattc
    15721 gcttgattga tcggtatggg gtaaccattg ttcaaaaatg taagaataat tattattctc
    15781 cagaactgaa gcaagagata ataaataaag tcttgattga cggccaatct cagaaacaaa
    15841 catccttaga ttatgcttta ccaacttcta gtatgctctc aaggtggata gcgcaataca
    15901 agaaaaacgg ttatactatt cttgaaaaac caagagggag accgagtaag atggggcgta
    15961 aacgtaagaa aaatttggaa gagatgacag aggttgaacg tcttcagaag gaattagaat
    16021 atcttagagc ggagaatgct gtgctaaaaa agctgagaga ataccgcttg agagacgaag
    16081 caaaactcaa agagcaacag aaatcattca agcattaagg aatcaatttc ccttagagat
    16141 gctacttgaa atccttgatt tatcacgctc cacctattac tatcaagtga agcgactagc
    16201 tcaaggagat aaggatatag aactaaagca tgtgattcga gagatttatg atgagcataa
    16261 aggtaattac ggttatcgtc gtattcatat ggagttgcgt aaccgaggat ttgtggtcaa
    16321 tcataagaaa gttcaacgtc tcatgaaagt catgggccta gcagcccgca ttcgtcgtaa
    16381 gcgcaagtac tcttcttaca aaggtgaggt tggtaagaag gctgataatc tgattaaacg
    16441 tcacttcgaa ggctctaaac cttacgaaaa atgttacact gatgtgacgg agttggcctt
    16501 acctgaaaga aaactcttct tatcacctgt tcttgacggc tataacagtg agattattga
    16561 tttcactctg tctcggtctc ctaacttgaa acaggttcaa accatgcttg agaagacttt
    16621 tccagcggat tcatacagcg gaactattct tcatagtgac caggggtggc aataccaaca
    16681 ctagtcctac catgattttt tagagtctaa aggtattctg ccatccatgt cccgcaaagg
    16741 gaatagcccg gataacggca tgatggattc cttctttggc attctcaaat ctgaaatgtt
    16801 ttatggactc gagacaactt atcaatcact tgacaagctt gaagaagcta ttacagatta
    16861 cattttttac tacaacaaca aacgaatcaa agcaaaacta aaaggattta gtcctgtcca
    16921 atacagaact aaatcctttc aataattatt tgtccaactt tttggggtca gtacactcct
    16981 agttaacgac tttgattgat tttattatga tgaatcgtga tttctgaaaa caaaattttc
    17041 ttcatggatt tggcgtggaa cttttacaat aaaaacacta acctctccct atcgtttttt
    17101 caggtgaatg cttggaattg gtataataag cggacacgaa tcaggtgaaa acagggaaag
    17161 tatttgaaga ggcgtttaaa ctatctgaca taaaactcgt tctagaggaa agacatcctt
    17221 taaaaagtta gtttattttg caacttagac atcaaggtag gttaaaccct tcatggaaaa
    17281 atcgagactc ttagcactat gggttaaact accactggag acgtaatcaa tcgctaaacc
    17341 acgaaaacgg ctaatagtgg tcatatcaat atttccagaa cattcaatcc gagaacgtcc
    17401 tgcaattaga gtaatggcct gttcaatctg ttccaatgac atattatcca acatgataat
    17461 atcaacaccc gccgccgcag cttcttcggc agcagcaagg ctttccactt ccacctcgac
    17521 cattttcaca aaaggggcat aggcacgcgc ttgagcaatc gccttttgaa cactacctac
    17581 tgccgcaatg tgattgtctt ttagcatgat agcatctgat aaattaaagc gatgattata
    17641 gccaccgcca actctcacgg catatttctc aaaaagacgt aaattaggag tggtttttcg
    17701 agtatcaaat accttaatgc gatcatcgcc taaggcttct acataagcag ctgtcatcga
    17761 agcaatccct gataaatgtt gtaaaaaatt caaggcaacg cgttcacatg ttaagaggct
    17821 tctcaccgag cctatgattt ctaaaaccaa atcgccacta gtcaaacgat ccccatcctt
    17881 aaattgatga ggattctgga aggtcacctc ggcatcaaat agggtaaaaa ccctttgaaa
    17941 aacggttagc cccgctaaaa caccagcttc cttggcaaaa agcgacacct tggcttggcc
    18001 atgatgatca aaaatggcat tggtactgta atcttcggaa tgaacatctt ctcgcaaggc
    18061 tgctttcaat gtatcatcta tttgaaaagg ggttaaatca gttgaaatga ttgacatcac
    18121 taagtcctct atttttaata tcacttgtaa gcactagagg caattgctat taacttccgt
    18181 aggaaatcac aaacctgaat acctcatttt aaatcccaac aagtgtcaag acaattgtaa
    18241 tttttttgtg tataatagtc aagtaccaat aggaaacagg tggtcttttg agcgccaaaa
    18301 ttgccaacct attttcatat tctaactaaa ggacaattca atgattcatt taataataat
    18361 tagcgccatt gctctagcca ttggaattgg ttaccgcacc aaaatcaata ttggcctact
    18421 ggctattgct ttttcttacc tcatcgcaac cactctcatg ggattaagcc ccaaagaact
    18481 tcttcatttt tggccaacct cactcttttt taccattttt agcgtctctc tcttttataa
    18541 cgttgcaaca actaacggca ctcttgatgt tttggctcaa cacattctct accgcacacg
    18601 cacccaccct aacgccatct acatgatttt atacctgata gcaacccttt tgtctgcttt
    18661 aggtgctgga tttttcacta ctatggccgt ttgctgtcct ctagcgatta ccctctgtca
    18721 aaaagcggac aaacaccctt tgattggagc tcaagccgtc aattggggag cttcaggagg
    18781 ggctaatttg ataaccagtg gctcaggcat tgtctttcaa ggcctgttta agcaaatggg
    18841 atgggaagag caagcttttt cacttggcaa tcatatcttt atcgtcagca ttatctaccc
    18901 actcatcgtc ttgcttttat tatcttgtta catccgctac agtaagggaa gaacaaactc
    18961 atccttgact attgaccaac caccagtcct cagcaaggtc caaagacaaa ccaccttgct
    19021 catgatcagc agcatggttt tggtttggct ttttcccttg ttgcatctca ttttcccaaa
    19081 catcgcatgg atagctactt atcgacaaac atttgatatt ggctttgtct caatactcat
    19141 ggtctgcctc gccttaaggc tcaaattagg gaagcaagaa gccattttgg ctaaggttcc
    19201 ctgggctata attatcatgc tctgcggcat gagcttacta atgtctctag cggtcaagtc
    19261 aggtttagtc acactgatag ggcacctcat aacaacaacc attcctcatt tctggttacc
    19321 tctgttcttt tgtgtgatag ccggagtgat gtcactcttt agttccaccc tatccgttgt
    19381 agccccaact ctctttccca tcattgctac catcagtgct caaagtcctc acattgatat
    19441 tcgcttactc acaacagcca ctattattgg cgctctatct actaatatct ctcctttttc
    19501 atcagctggt tccctcattc aactctccct tccccatata gaggaacgca gtcttgcttt
    19561 caaaaaacaa attcttctgg gtgtgcccat cagcttaagt ttggcactct tgaccatctg
    19621 gattctcatg ctgctagctt ccttaagtta gatttattgt ctaacatttg gttggacttg
    19681 gtataataaa gtagacacaa aattaagtgg aaacgaggaa aagtcattat gccaagaaaa
    19741 acctttgata aagccttcaa actctctgct gtaaaactca tccttgagga agagcagcct
    19801 gtaaaaatgg ttagttcaac tttaaaaatt catcccaata gtctttatcg atggattcaa
    19861 gaatatgaaa aatatggaga aagtgcgttc ccaggacatg ggagcgcact tcgtcatgct
    19921 caatttgaga taaaaaaact tgaaaaagag aacaaactgc tacaggagga attagctctt
    19981 ctaaaaaagt tccaggtctt cttgaagcca aaccggaaat aaaatttcag tttctgaagg
    20041 aaaatagtgt tagcttgaat agtcatcacg cctgtcaaac tcttcaagtc tcccgttcag
    20101 gtttctatgc ttatttaaaa cgtcgtctat cttcaaagca tgttgagaat gaagctttga
    20161 aggaaatgat taaagacatt ttctatgaac ataaagagcg ttacggaagt gtacgaatta
    20221 cccaagaact ttgtagacgt ggcatccatg tcaatcataa acgtgttggt agactccttc
    20281 atcagctagg tctctatgct aaaggaagtc gatatcaata taaatactat aaccgtcgac
    20341 gttcttcatt aactcgtccc aatcttgtta atcaatgttt ccaagcgact ggtaagaata
    20401 aattatagct aggagactta acctacattc ctacacaaga aggaatactt tatgtgtctg
    20461 tcttgataga cgtttatagt agaa
//
LOCUS       DAUDWO010000034        20336 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.034, whole genome shotgun sequence.
ACCESSION   DAUDWO010000034 DAUDWO010000000
VERSION     DAUDWO010000034.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20336)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20336)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20336
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.034"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(<1..802)
                     /locus_tag="VHC05_001311"
     CDS             complement(<1..802)
                     /locus_tag="VHC05_001311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEQ5402612.1"
                     /translation="MVTIKDVAQKAGVNPSTVSRVLKDNRSISMKTKEKVRKAMADLG
                     YVPNVAAQILASGLTHNIGLVFPPITTSDRLSEPFFMEILSTITNEAKESHFTVSIAT
                     GISLDDLIEQVKLMHLQKRVDGFIILYSDQDDPVKKYLMTNNLPFVIVGAPQGDTNKT
                     TYIDNDNQLMAKTAVEHLYQKGHHNILFITDDLLSEVTSERYLGYLKGCFKRSLKTKP
                     MLLFDRKDPVSVEILMETISSFKATALVVVGDVLAIRMVQLLSFYDIKV"
     gene            1046..2293
                     /locus_tag="VHC05_001312"
     CDS             1046..2293
                     /locus_tag="VHC05_001312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEQ5402613.1"
                     /translation="MKSWQKVIVGGASLTLASTLLVGCGSGSKDKKEAGADSKTIKLW
                     VPTGSKKSYADIIAKFEKDSGYTVKVVESEDPKAQEKIKKDASTAADVFSLPHDQLGQ
                     LVESGTIQEVPEKYNKEIAATSTDQALVGAQYKGKTYAFPFGIESQVLFYNKSKLTAE
                     DVTSYDTITTKATFGGTFKQANTYATGPLFMSVGNTLFGENGEDVKGTNWGNEKGAAV
                     LKWIADQASNKGFVSLDANNVMSKFGDGSVASFESGPWDYEAAQKAIGKENLGVAIYP
                     KVTIGGETVQQKAFLGVKLYAVNQAPAKGDTKRIAASYKLASYLTNAESQENQFKTRN
                     IVPANKEVQSSEAVQSNELAKTVITMGSSSDYTVVMPKLSQMGTFWTESAAILSDAFN
                     GKIKESDYLTKLQQFDKDIAATK"
     gene            2567..3928
                     /locus_tag="VHC05_001313"
     CDS             2567..3928
                     /locus_tag="VHC05_001313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEQ5402614.1"
                     /translation="MTQSNLTPNISVIEALKRGSWDIKLSSIIMGFANFANKQFIKGI
                     LFLISELIFLVAFVSQIIPAIRGLVTLGTQTQGMTTKTIDGINIQVAVDGDNSMLMLI
                     FGLASLIFCLVFAYIYWCNLKSARNLYLFKQKGQKIPSFKEDLATLTNGRFHMTLMAI
                     PLIGVLLFTILPLIYMICLAFTNFDHNHLPPKSLFDWVGLANFGNVLSGRMAGTFFPI
                     FSWTLIWAVFATVTNFFFGIILALLINTKGLKWKKMWRTIFVITIAVPQFISLLIMRN
                     LLNDEGPLNALLNKIGLINGSLPFLSDPLWAKFSIIFVNMWIGIPFTMLIATGIIMNL
                     PSEQIEAAEIDGASKFQVFKSITFPQILLIMTPNLIQQFIGNINNFNVIYLLTGGGPT
                     NSEYYQAGTTDLLVTWLYKLTVTAADYNLASVIGILIFTVSAIFSLLAYTRTASYKEG
                     AAK"
     gene            3928..4764
                     /locus_tag="VHC05_001314"
     CDS             3928..4764
                     /locus_tag="VHC05_001314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEQ5402615.1"
                     /translation="MKNKRRFQLGLVYATLIILSIIWLFPIAWVILTSFRSEGTAYVN
                     YFIPKTFTLNHYINLFTNETFPFGKWFMNTLIVATFTCIISTFITVAIAYSLSRIKFK
                     FRNGFLKLALILNMFPGFMSMIAIYYILKALGLTQTLTALVLVYSSGAALGFYIAKGF
                     FDTIPYSLDESAMIDGATRMDIFFKITLPLAKPIIVYTALLAFMGPWIDFIFAQVILG
                     DATSKYTVAIGLFSMLQPDTINNWFMAFTAGSVLIAVPITLLFMFMQKYYVEGITGGS
                     VK"
     gene            4922..5719
                     /locus_tag="VHC05_001315"
     CDS             4922..5719
                     /locus_tag="VHC05_001315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEQ5402616.1"
                     /translation="MTSKITIKDIAREAGVSVATVSYVLNQRNDQKISEETRNKVLHI
                     SNLLNYTPNQAARSLVTQQSNSVVLYYKYADSILARAEQLHTISFLSRLLHEQDYQLV
                     CLNEDSIEKFDWADLILTLDVDNDTFYKIGKLNFKPLIAIDSFVNDPLFFQINTDYAA
                     LKDQANQFFKDEPYTLLSLPITNRERYEHVSAFFPSLHIVNDLRELTYFEKENLLLID
                     ESLDQFFVNSSQKLYCPRFSPKKGQVILEAIEWAKKRQPDKKHNLLV"
     gene            complement(5835..6650)
                     /locus_tag="VHC05_001316"
     CDS             complement(5835..6650)
                     /locus_tag="VHC05_001316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003060440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1189 domain-containing protein"
                     /protein_id="HEQ5402617.1"
                     /translation="MPDKKQFPISYISHCLSPRAMFASRAQFTWWQNLLIIVFLNALI
                     MIPVTLHYANMTTYPLERIVTKSLSPITDKTYQALTQGKIEKDTFQGQSLIRRDGELV
                     LAVLPTKVDLEQLPSESTRQIIVTKKEWRFVTPDGKELRAHVRGQQQSLADLTTVKAV
                     KDFVNQQWYDSNKASVLGFLLLTFVLMVCVGTLIVIGLGAFFLTLTKRSRLFMIRNFS
                     EGLGLMVNCLAWPSLLAIALSFFIQDPVLIMNCQVFGTLLMLTWVFYKTQFRD"
     gene            complement(6672..7532)
                     /locus_tag="VHC05_001317"
     CDS             complement(6672..7532)
                     /locus_tag="VHC05_001317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEQ5402618.1"
                     /translation="MRKTYVSISMKRKRFFTQLLTYLYLISLVIVILFPILVTVSSAF
                     RPGNTTAFSFHFDGPWTLSNFKTLFQDTLYLRWYWNTLIVAFFTMLIQVTVITLTGYA
                     YSRYNFFGRKKSLIFFLVVQMVPTMAALTAYFVMAWLFNALNQYWFLILIYVGGGIPM
                     NAWLMKGYFDTVPYDLDESAKLDGSGHFRTFYQIVLPLVRPMIAVQSLWAFMGPFGDF
                     MLAKFLLRAQENYTVAVGLQSFITNDARNPKVTLFAAGAILIAVPISVLFFFLQKNFV
                     SGLTSGGTKG"
     gene            complement(7529..8836)
                     /locus_tag="VHC05_001318"
     CDS             complement(7529..8836)
                     /locus_tag="VHC05_001318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEQ5402619.1"
                     /translation="MVDNQRQQKPNKAMWLSVIPGLGQLYNKQIVKGGVLLVVFFLEL
                     LEIVVLGIPALTGLYSLGSVPMQDHSLFMLIKGAMQLITLVLFGIFHLVAMRDAKLVA
                     HQMNEGKKVPVTAKETLEAIYEKGFPYLLIIPAYLAMAFAIIFPVLVTLLIAFTNYDF
                     RHIPPYRLLDWVGLKNFLNILELSTFKTAFTSVLSWTLIWTLAATSLQIVIGIATAVI
                     ANQSFIRGKRLFGVIFLLPWAVPAFISIMSFGNFFNDSIGAMNVQVLPFIEKFLPFVD
                     FGIVSWKTDPFWTKVAVIMVQGWLGFPYIYILVSGILQAIPADLYEAATVDGATVLQK
                     FRHITMPMIFAVAAPTFISQYTFNFNNFSIIYLFNNGGPGTVGGGAGTTDILISWIYK
                     LTTQTSPQFSMASAVTLIISVIVISVSLITFKKFKAFDMEERS"
     gene            complement(8911..11046)
                     /locus_tag="VHC05_001319"
     CDS             complement(8911..11046)
                     /locus_tag="VHC05_001319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclomaltodextrin glucanotransferase"
                     /protein_id="HEQ5402620.1"
                     /translation="MRELHIKTYKLLTKSAVLLGLISFPLTVSAADNASVTNKADFST
                     DTIYQIVTDRFNDGNTSNNGKTDVFDKNDLKKYHGGDWQGIIAKIKDGYLTDMGISAI
                     WISSPVENIDSIDPSNGSAAYHGYWAKDFFKTNQHFGTEADFQQLVKVAHQHHIKVVI
                     DFAPNHTSTAEKEGTTFKEDGALYKNGKLVGKFSDDKDKIFNHESWTDFSTYENSIYH
                     SMYGLADLNNINPKVDQYMKEAIDKWLDLGVDGIRVDAVKHMSQGWQKNWLSHIYEKH
                     NVFVFGEWFSGHTDDDYDMTTFANNSGMGLLDFRFANAIRQLYTGFSTFTMRDFYKVL
                     ENRDQVTNEVTDQVTFIDNHDMERFATKVANNQTAVNQAYALLLTSRGVPNIYYGTEQ
                     YATGDKDPNNRGDMPSFNKESQAYKVISKLAPLRKQNQALAYGTTEQRWISDHVLVFE
                     RKFGNHVALVAINRDQTNGYTITNAKTALPQNSYKDKLEGLLGGQELIVGADGTISSF
                     ELGAGQVAVWTYEGEDKTPQLGDVDASVGIAGNKITISGQGFGNSKGQVTFGEISAEI
                     LSWSDTLITLKVPTVPANYYNISVTTADKQTSNSYQAFEVLTDKQIPVRLLINDFKTV
                     PGEQLYLMGDVFEMGANDAKNAVGPLFNNTQTIAKYPNWFFDTHLPINKEIAVKLVKK
                     DSIGNVLWTSPETYSIKTGHEAQTITIKK"
     gene            complement(11072..12775)
                     /locus_tag="VHC05_001320"
     CDS             complement(11072..12775)
                     /locus_tag="VHC05_001320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glycosidase"
                     /protein_id="HEQ5402621.1"
                     /translation="MNVAGMLHIPDSRYCFAISQKELVIRLRVAKEDRGITVNLVHGP
                     KYGYHEFQEELEMSVAYTDHTHAYYETTLTLDDVRLAYIFKIEEEGQTYYFSEDGLTT
                     SYDFSNGFYNFFQMPYINAVDVHQVIPWTKDAVFYQIFVDRFNRGDWEKGDSYVNMGW
                     LEKPTPKSFAGGDLKGITEKLDYLKDLGITVIYLTPIFQSISNHKYDISDYYAIDPQF
                     GTKYDLQELIDLAHQMGIKIILDAVFNHASSDAVEFQDVLRYGKESKFFDWFMTHDEH
                     PSMDLVNYETFAGCNYMPKWNTSNRDVQDYLIEIGRYWIKEFCIDGWRLDVSDEVSHD
                     FWRRFRQAVKAEKADAILIGENWHDAYPYLAGDQYDGIMNYAFTKACLDYFAFETMTS
                     KQLAEKLSNILMRNTWQVNRMNLNLLDSHDTHRFFTQVKGSKDKLLAALALLFIFMGI
                     PCLYYGTEVAMEGGYDPDSRRGFPWDDAERDKDFFSKVKAIIALRQQPALQEGAISID
                     YDEDCLILKRSLGEQSISLVLNNGESAYSIKEGGQILTSNGVTKNKKQLLQDGYIVFS
                     N"
     gene            complement(12941..14200)
                     /locus_tag="VHC05_001321"
     CDS             complement(12941..14200)
                     /locus_tag="VHC05_001321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062623.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEQ5402622.1"
                     /translation="MSWNWKKTSVLGTLSLASVLPLTACVSGGGKGVKETDGKTIVVS
                     VDEGYVDYIKSIKGEFEKEHKVTVKVKKEGMMDTLDKLSTDGPTGASPDVFLAPFDRV
                     GGLGTEGQIAEVTLGNSKEFDDTVKKLVTIDGKTYGAPDVIETLVTYYNKDLVPQAPK
                     SFTELEVLQKDSKFAFASEPGKSVGFLAKWTDFYYGYGLIAGYGGYIFGDKGTKPSDL
                     GLGNDGTVEGLNYAKQWYGTWPQGMQDTKKAGDFITEQFISKKAGVIIDGPWAASSFK
                     DAGVNFGVMEIPTLTNGKKYQPFAGGKAWVISNYSKGKTTAQKFLDYVTNAENQKRFY
                     DKTQEIPANLTARNYASKEGNELTKAVISQFESAQPMPNIPEMAEVWEPGANMFFNVA
                     SGKEEASKAAKEAAKTIKEAIEQKYAE"
     gene            complement(14820..15803)
                     /locus_tag="VHC05_001322"
     CDS             complement(14820..15803)
                     /locus_tag="VHC05_001322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEQ5402623.1"
                     /translation="MVIIAVVIFFGVILGILIVEYGQKRSFSSWLVEKMFAYRKYKLS
                     KKVDNYKGVETQRNRNIPYHLDNPEEIVGFSTQEYDVNGMQVFIINDQKQSHQPVIYY
                     LYGSVYLRRPEKLHFKTVKHLIQLTNAKLVFPNFPKVPYATYQDVYPKLVEAYQQFCL
                     SNGPSQVSVIGDSSGGGMALAFAKYIRDTKTAPQPKQLILISPWLDVSFKNQAYKDFE
                     AEEAYLDARRLRDIGELWAGGQGNMQLPYVSPLYGDYEDLPEITTFVGTKEIFYPDIM
                     SLHDQLTRQRIANQLIIAEKMIHAYVIFPIREAKQARKQIVELVLKTVEHT"
     gene            complement(15834..17084)
                     /gene="dltD"
                     /locus_tag="VHC05_001323"
     CDS             complement(15834..17084)
                     /gene="dltD"
                     /locus_tag="VHC05_001323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltD"
                     /protein_id="HEQ5402624.1"
                     /translation="MLKRLWLILGPLLIAFVLVVITIFSFPTQLDHSIAQEKANAVAI
                     TDSSFKNGLIKRQALSDETCRFVPFFGSSEWSRMDSMHPSVLAERYKRSYRPFLIGKR
                     GSASLSHYYGMQQITNEMQKKKAIFVVSPQWFTAQGINPSAVQMYLSNTQVIEFLLKA
                     RTDKESQFAAKRLLELNPGVSKSNLLKKVSKGKSLSRLDRAILKCQHQVALREESLFS
                     FLGKSTNYEKRILPRVKGLPKVFSYKQLNALATKRGQLATTNNRFGIKNTFYRKRIAP
                     KYNLYKNFQVNYSYLASPEYNDFQLLLSEFAKRKTDVLFVITPVNKAWADYTGLNQDK
                     YQAAVRKIKFQLKSQGFHRIADFSKDGGESYFMQDTIHLGWNGWLAFDKKVQPFLETK
                     QPVPNYKMNPYFYSKIWANRKDLQ"
     gene            complement(17077..17316)
                     /gene="dltC"
                     /locus_tag="VHC05_001324"
     CDS             complement(17077..17316)
                     /gene="dltC"
                     /locus_tag="VHC05_001324"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltC"
                     /protein_id="HEQ5402625.1"
                     /translation="MSIEETVIELFDRLFMEDVSEMMDEDLFDAGVLDSLGTVELIVE
                     LESTFNIKVPISEFGRDDWNTVTKIVQGVEELQHA"
     gene            complement(17334..18590)
                     /gene="dltB"
                     /locus_tag="VHC05_001325"
     CDS             complement(17334..18590)
                     /gene="dltB"
                     /locus_tag="VHC05_001325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltB"
                     /protein_id="HEQ5402626.1"
                     /translation="MMMFFSHIPYMEPYGNPIYFVYLILAFLPVIIGIFKQKRLSTYE
                     TLVSLVFILFMFGGDHYQQLVAFLFYLLWQIISVFAYQKYREKANSAGVFYLAIAMAL
                     FPLIWVKVAPLTGPSSQTLFSFLGISYLTFKSIGMIIEMRDGTLQEVRLPDFIRFMIF
                     FPTFSSGPIDRFRRFQEDYHKLPERDDYFAMLNKAVMYLMLGFLYKHIISYCLGGILL
                     PLLENKALMVGGYFNKETILVMYVYGLNLFFDFAGYSMFAIGISYLLGIRTPENFNMP
                     FLSASLKDFWNRWHMSLSFWFRDYVFMRLVHLLIKHKTFKNRNVTSGVAYLVNMLVMG
                     FWHGLTWYYIAYGLFHGIGLIINDAWIRKKKEINRHRKKKGLSPLFQSRAFHVLCIVV
                     TFHVVMFSLLLFSGFLNDLWFNRPLH"
     gene            complement(18587..20125)
                     /gene="dltA"
                     /locus_tag="VHC05_001326"
     CDS             complement(18587..20125)
                     /gene="dltA"
                     /locus_tag="VHC05_001326"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltA"
                     /protein_id="HEQ5402627.1"
                     /translation="MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAF
                     IDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAYIPVDVHSAPERILAIIEIAKPS
                     LIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPK
                     GVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFAL
                     PKELVADFKQLFTTIAQLPVGIWTSTPSFADMAMLSDDFCQARMPALTHFYFDGEELT
                     VSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTRLPIGYPKPDSPTYI
                     IDEDGKELASGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTED
                     NILLYGGRLDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIV
                     VKDGVKERFDRELELTKAIKASVKDHMMSYMMPSKFLYRDSLPLTPNGKIDIKTLINE
                     VNNR"
     gene            complement(20137..20280)
                     /locus_tag="VHC05_001327"
     CDS             complement(20137..20280)
                     /locus_tag="VHC05_001327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="teichoic acid D-Ala incorporation-associated
                     protein DltX"
                     /protein_id="HEQ5402628.1"
                     /translation="MIKNKSRMRGIAVFIGKTILFYLILMLLVYFFGYLGHGQSNFIY
                     NEF"
BASE COUNT         6505 a         4138 c         3403 g         6290 t
ORIGIN      
        1 gcacttttat atcataaaaa gataataact gtaccatacg aatagccaga acatcaccaa
       61 caacaaccaa ggcagttgct ttaaaggaag atatagtttc catcaatatt tctacgctaa
      121 caggatcctt acgatcaaat aacagcattg gctttgtttt taaagatcgc ttaaaacaac
      181 ccttcaaata gccaagataa cgctcagaag ttacttctga tagtaaatca tctgttataa
      241 ataatatgtt gtgatggcct ttttgataaa ggtgttctac tgctgtttta gccattagct
      301 gattatcatt atcaatataa gtggttttat tagtgtcacc ttgtggagca cctacaatga
      361 caaatggtaa gttatttgtc atcaaatatt ttttgacagg atcatcttga tcagaataaa
      421 gaataataaa accatcaact cgtttttgaa gatgcatcag tttcacttgc tctatcaggt
      481 catcaagaga tatacctgta gcaatcgaca cagtaaaatg agattcttta gcttcgttag
      541 taatagtcga caaaatttcc ataaagaaag gttcacttaa tctatcgcta gttgtaatag
      601 gaggaaaaac aagtcctata ttgtgtgtca aaccactcgc tagaatctgt gctgcgacat
      661 ttggaacata tcccaaatct gccatcgctt ttctaacctt ctcttttgtt ttcatagaaa
      721 tagatcgatt atcttttaat accctactca ccgtcgaagg gttaacacct gccttttgag
      781 cgacatcttt tattgttacc atattaacct cgttactata tttaccaaag ataaacctta
      841 tcatgggttt gtcatgtatt tcgtttccat tatacaatta tctttcaaaa aatcaacttc
      901 aatcaagatt cccttgtcat tttaactcaa attctctaaa ctattttttt aaaaaaacga
      961 ctttttttta aaaaaaggct tgactttttc tgcaagcggt tgcataatat taagtgtaag
     1021 aaatatatct taggaggaaa tagctatgaa atcatggcaa aaagttatcg tcggcggagc
     1081 aagtttgaca cttgcaagta ccttgttagt gggatgtgga tcaggttcaa aagataaaaa
     1141 ggaagctggc gctgactcaa agactattaa actttgggta ccgactggct ctaaaaaatc
     1201 atatgcagat atcattgcaa aatttgaaaa agattctggt tacaccgtta aagtggttga
     1261 atcagaagat ccaaaagcac aagaaaaaat caaaaaagat gcctcaactg ctgccgatgt
     1321 cttttcactt cctcatgatc aacttggtca acttgtagaa tctggtacta ttcaagaagt
     1381 tccagaaaag tacaataaag aaattgctgc tacttctact gatcaggcgc tcgtcggtgc
     1441 acagtacaaa gggaaaacat atgctttccc atttggtatt gaatcacaag ttcttttcta
     1501 caataaatca aaattaactg ctgaagacgt tacttcatat gatacaatta ctacaaaagc
     1561 aacttttggt ggtaccttta aacaagctaa cacttacgct actggtccat tattcatgtc
     1621 agttggtaac actttatttg gggaaaacgg tgaagatgta aaaggtacta actggggcaa
     1681 tgaaaaaggc gctgctgttc ttaaatggat cgcagaccaa gcttcaaata aaggttttgt
     1741 tagcttagat gctaacaacg ttatgtctaa atttggtgac ggttcagtag cttcttttga
     1801 atcaggaccg tgggactatg aagctgctca aaaagctatc ggtaaagaaa accttggtgt
     1861 tgctatttat ccaaaagtaa ctattggagg cgaaacggtt caacaaaaag cattcttggg
     1921 tgtaaaactt tacgcagtca accaagcacc agctaaaggt gatacaaaac gtatcgcagc
     1981 tagctacaaa ttggcatcct acttgactaa tgctgaaagc caagaaaacc aattcaaaac
     2041 tcgtaacatt gtcccagcca acaaagaagt tcaatcttca gaagctgttc aatcaaacga
     2101 acttgctaaa accgttatca ctatgggttc ttcttcagac tacactgtcg taatgccaaa
     2161 acttagccaa atgggcacat tctggactga aagtgctgct attcttagtg atgccttcaa
     2221 cggtaaaatc aaagaaagcg actaccttac taagttgcaa caattcgaca aagatatcgc
     2281 tgcaacaaaa taatatgatc tcatgtcatc actgctatac taaaacaagc acaaggtaag
     2341 tacttctaaa aagttctttc cacttacctt atgaagagtg gaactaggct ccatcacatt
     2401 ttattcaagc ttagtctcac tcttacttgt ttttgtttta ctagtagctt agtgctactt
     2461 aaatttttaa ctctttaaaa gtttacgtaa cacttagcta tttcatccta acaagagatt
     2521 gaatctgaac taccactcta gtatcctaaa ataaaggaga atctatatga ctcagtcaaa
     2581 cttgacacca aatatatctg taatagaagc tttaaaaaga ggcagttggg atattaaact
     2641 ttcgagtatt atcatgggat ttgccaactt tgctaacaaa cagtttatca aaggaatctt
     2701 atttttaata agtgaactta tctttctagt agcttttgtc tcccaaatca tccctgctat
     2761 ccgtggcctt gtcactcttg gtactcaaac tcagggaatg actacaaaaa ctattgatgg
     2821 gattaacatc caagttgctg ttgatggcga taactctatg ttaatgctta tttttggttt
     2881 agcatcactc attttctgcc tagtctttgc ttacatttac tggtgtaatc tcaaaagtgc
     2941 tcgtaacctt tatcttttca aacaaaaagg tcagaagata ccaagcttca aagaagatct
     3001 tgccacactt acaaatggtc gctttcatat gactttaatg gctatcccac tgattggtgt
     3061 gcttttattc accattcttc ctttgattta catgatctgt ttggccttta ccaattttga
     3121 tcataatcac ttgcctccaa aatctttatt tgattgggtg ggacttgcta actttggaaa
     3181 tgttttaagc ggccgtatgg caggaacctt ttttcctatc ttctcatgga ctttgatttg
     3241 ggctgttttt gccacagtaa ctaatttctt ctttggtatt attcttgctt tgttaatcaa
     3301 taccaaagga ttaaagtgga aaaaaatgtg gcgaaccatc tttgttatca ccattgcagt
     3361 tccacaattc atctcattat tgattatgcg gaacttactc aatgacgaag gcccactaaa
     3421 tgctcttctc aataaaatcg gcttgattaa tggctcactg ccatttttat ctgatcctct
     3481 ttgggcaaaa ttctcaatca tttttgtcaa catgtggatc ggtattccat ttaccatgct
     3541 gattgcgact ggtattatca tgaaccttcc aagtgaacaa attgaggctg ctgaaattga
     3601 tggcgctagc aaattccaag tcttcaagtc tatcacgttc cctcaaattc tcttgatcat
     3661 gacaccaaac ttgattcaac aatttatcgg aaatatcaat aactttaacg tcatttacct
     3721 ccttactggt ggtggtccaa caaattcaga atactatcag gcaggaacaa cagacttgct
     3781 ggtcacttgg ctttataaat taaccgtcac agctgctgac tacaatttag cttctgttat
     3841 cggtatctta atctttacag tttcagctat ctttagctta cttgcttata caaggacagc
     3901 atcctacaag gaaggagcgg ctaaataatg aaaaacaaac gtcgatttca acttggactt
     3961 gtttatgcta ctttaatcat cctctcaatc atttggctct tcccaatcgc ttgggttatt
     4021 cttactagct tccgtagcga aggaactgct tacgtcaatt attttattcc taagactttt
     4081 acattaaatc actacattaa tctttttact aatgaaacct ttccttttgg aaaatggttt
     4141 atgaatactc ttattgtagc cacttttaca tgtattattt caaccttcat aactgttgcc
     4201 atagcctact ctcttagccg aattaagttt aagtttcgca atggcttttt aaaactagcc
     4261 cttattttaa atatgttccc tggtttcatg agcatgattg ccatctacta tatcttaaag
     4321 gccttaggtt tgacgcaaac cctaacagca cttgtccttg tttattcctc aggtgcagcc
     4381 cttggttttt acattgcaaa aggatttttt gataccattc cttattcact tgatgaatca
     4441 gctatgattg atggcgctac tcgtatggat attttcttta aaataaccct tcctttagca
     4501 aaaccaatca ttgtctatac tgcccttctt gcttttatgg ggccttggat tgactttatc
     4561 tttgcacaag ttattttagg tgatgctaca agtaaatata ccgttgctat tggactattt
     4621 tcaatgcttc agccagatac cattaacaac tggtttatgg ccttcactgc tggttctgtc
     4681 ttaattgccg tcccaatcac tctcctcttc atgtttatgc aaaaatacta tgttgaaggc
     4741 atcacaggtg gttctgttaa ataagttaca acataccaaa ccttctaagg gcaagccctt
     4801 taggaggttt ttgataaata aggccgtaga taatcatatt agtcctcaca tttatcttca
     4861 gatcagccaa atgtattaat gattccttga cttttaccat gaattcggat ataacaaaat
     4921 gatgacatct aaaattacca ttaaagatat tgcacgagaa gccggggttt ctgtggcgac
     4981 cgtatcttac gtgttaaacc agcgcaatga tcaaaaaatc agcgaagaaa cccgcaataa
     5041 agtgctacat attagtaacc ttcttaacta tacacctaat caggcagcca ggtcattagt
     5101 cacacaacaa tcaaacagtg ttgtcctgta ttacaaatat gcagatagca ttttagctag
     5161 ggctgaacaa ctgcatacca ttagctttct atcccgccta ttgcatgagc aggactatca
     5221 gctggtttgc ctaaatgaag atagcattga aaaatttgac tgggcagacc ttattctgac
     5281 cttggacgtt gataatgata ccttttacaa aattggaaag cttaatttca aacccttaat
     5341 tgccattgat agctttgtta atgatcccct cttctttcaa attaatacag attatgctgc
     5401 tctcaaagat caggctaatc agttttttaa ggatgaacct tataccctgc tttccttgcc
     5461 tatcactaat cgtgagcgat atgagcatgt ttctgccttc tttccaagtt tgcacattgt
     5521 aaacgaccta agagagctaa cctactttga aaaggaaaat cttttactca ttgatgagag
     5581 tttggatcaa ttctttgtga actcttcgca aaaactctac tgcccacgtt tttcccccaa
     5641 aaaagggcaa gttatcttag aggccatcga atgggccaaa aaacgccagc ctgataaaaa
     5701 acataacctt ctggtgtaac gcctgagaat taacctatct tgactaattc cttgtaactc
     5761 aaaaccttgc ctctttagat aaagaagcaa ggttttttga tgtctaatct aataacaggg
     5821 cctgacttgt ctcatcaatc tctaaactgt gttttgtaga acacccaggt cagcattaat
     5881 aaggtaccaa atacttggca attcataatc agtactggat cctgaataaa gaaactaaga
     5941 gcaatcgcca gtagactcgg ccaagccaaa caattaacca tcaatccaag tccttcagag
     6001 aagtttcgaa tcataaatag tcgtgatcgt ttagtcagag tcaaaaagaa agcgcctaga
     6061 ccaatcacaa taagggtacc cacacacacc atgagaacaa acgtcagcaa aagaaaacca
     6121 agtacactgg ctttattact gtcataccat tgctgattga caaagtcctt cactgcttta
     6181 actgttgtca ggtcagcgag tgactgctgc tggcctctaa cgtgagcacg gagttccttg
     6241 ccatcagggg taacaaaacg ccattctttt tttgtcacaa taatttgtct ggttgattct
     6301 gatggcaatt gctctaaatc gacctttgtc ggtaaaacag ccaaaaccaa ttcaccatct
     6361 cgtcgaatca gagattgacc ctgaaacgta tctttctcaa tctttccttg ggtcaatgct
     6421 tgataggttt tgtctgtgat aggcgacaaa ctcttagtta caatccgttc caagggatac
     6481 gttgtcatgt tagcatagtg taacgtaact ggaatcatta ttaaggcgtt caaaaaaaca
     6541 ataataagaa gattttgcca ccaagtaaac tgagctcggc tggcaaacat tgccctagga
     6601 gaaaggcaat gtgaaatgta agaaatagga aattgttttt tatctggcat taaacattac
     6661 tccttgtcag gttacccttt ggtaccacca cttgttaaac cggaaacgaa atttttctgt
     6721 aggaagaaaa agagaactga aataggcact gcaatcagaa tagctcccgc agcaaataag
     6781 gttaccttgg gatttctagc atcattcgta ataaacgatt gaagaccaac tgctaccgta
     6841 taattttctt gcgcccttaa aaggaattta gccaacatga agtctccgaa aggacccata
     6901 aaagcccata aggattgtac tgcaatcatt ggtcgcacaa gaggaaggac aatttggtag
     6961 aaggtcctaa agtgtccaga accatctaac ttagcagatt cgtccaagtc ataaggtacc
     7021 gtgtcaaaat aacccttcat caaccaggca ttcataggaa taccaccacc gacgtaaatc
     7081 aaaatcaaga accagtattg gtttaaggca ttaaagagcc acgccataac aaagtaagcc
     7141 gttaaagccg ccatggtagg aaccatctgt acgactagga aaaagattaa actttttttg
     7201 cgtccaaaga aattgtaacg gctatacgca taacctgtca aagtgatgac tgttacttgt
     7261 atgagcatgg tgaagaatgc cacgatcaag gtattccaat accatcttaa gtataaggta
     7321 tcttgaaaga gtgttttaaa gttagacaag gtccatggcc catcaaaatg aaaactaaag
     7381 gctgtggtat ttcctggtct aaaagctgaa ctgaccgtca ctagtattgg gaataaaatc
     7441 acgatcacta aggagattag atagagataa gtcaataatt gggtgaagaa acgtttgcgt
     7501 ttcatggata ttgaaacata ggtctttctc atgatctctc ctccatatca aaagctttaa
     7561 atttcttaaa ggtaatcaac gataccgaaa tcactattac agagatgatt aaggtcactg
     7621 ccgacgccat cgaaaattga ggcgaggttt gtgtggtcaa cttgtaaatc caagaaatca
     7681 gaatatcagt tgtcccagct ccgcccccca cagtaccagg gcccccatta ttaaacagat
     7741 aaataataga gaaattattg aagttaaagg tgtactgaga gataaaggtt ggtgctgcaa
     7801 ccgcaaaaat cattggcatg gtgatatggc ggaatttctg taagactgtc gcaccatcaa
     7861 cggttgctgc ttcgtataaa tcagctggaa ttgcctgtaa aatacctgat accaaaatat
     7921 agatataggg aaatcctagc caaccttgca ccataataac agccactttt gtccagaagg
     7981 ggtctgtctt ccaggacaca attccgaagt caacgaaagg aaggaatttc tcgatgaaag
     8041 gaagaacctg aacattcatg gccccaatgg aatcattaaa gaaattacca aaactcataa
     8101 tagagataaa tgctggaaca gcccatggta acaagaatat cacaccaaag agacgttttc
     8161 ctctgataaa ggattgatta gcaataacag ccgttgcaat tccaataaca atttgaagac
     8221 ttgtcgctgc taatgtccag atcagcgtcc atgacaaaac agatgtaaat gctgttttga
     8281 aggtgcttaa ttctaagata ttaagaaaat tcttcaaccc tacccaatcc aataaacgat
     8341 acggaggaat atgcctaaaa tcgtaattgg taaaagcaat cagcaaggtc actaaaactg
     8401 gaaaaataat agcgaaagcc attgctaaat aagccggaat gatgagcaag taaggaaatc
     8461 ctttttcata aatcgcttca agggtctctt tagccgtcac cggaaccttc ttgccttcat
     8521 tcatttgatg tgcaactaat ttagcatctc tcatagcaac caaatgaaaa ataccaaata
     8581 agactagagt aattaattgc atggccccct taattaacat aaataaggag tgatcttgca
     8641 ttggaacact tccaagactg taaagacctg ttaaagcagg aattcctaga actacaattt
     8701 ctagtagctc taggaagaaa acaactaata agactccccc tttaacgatt tgtttattgt
     8761 atagttgtcc caaacctggg ataacagata gccacatggc tttattaggc ttctgttgtc
     8821 tttggttatc taccattttt tattcctctt ctcataaatg atttaaggtt atcctcctta
     8881 tcatactaac ttccttttaa gctgactaat ttattttttt atagtaatgg tttgtgcttc
     8941 atgacctgtc tttatactat aagtctcagg acttgtccat aaaacattcc caatactatc
     9001 ttttttaaca agtttgactg ctatttcttt attgattggt agatgagtat caaagaacca
     9061 gtttgggtac ttggcaatgg tctgagtgtt attaaataga ggaccaacag cattcttagc
     9121 gtcatttgcc cccatctcaa aaacatcacc catgagatat agttgttccc ctggtactgt
     9181 cttaaaatca ttgatgagta aacgaacagg aatttgttta tcagtcaata cttcaaaggc
     9241 ttggtaacta ttgctggttt gcttatcggc agttgtcact gaaatgttat aataatttgc
     9301 tggaaccgtc ggtactttta aggtgataag ggtatctgac caagaaagga tctcagcaga
     9361 gatttctcca aaagtcactt gacctttaga attaccaaaa ccttgacctg aaatagtaat
     9421 cttatttcca gcaataccca ctgaagcatc gacatctcca agttgtggtg tcttgtcctc
     9481 tccttcataa gtccatacag cgacttgccc cgctccaagt tcaaagctac taatagtgcc
     9541 atctgctcca actattaatt cttgaccgcc aagaagacct tctaatttgt ccttgtagct
     9601 attttggggc aaggctgttt tagcattagt aattgtataa ccattcgttt gatctctatt
     9661 aatagccact agtgcgacat gattaccaaa tttacgctca aataccaaaa catgatcact
     9721 aatccaacgt tgttcagttg ttccataagc taaagcttga ttttgttttc ttaaaggagc
     9781 tagcttacta atcactttat aggcttgtga ctctttatta aaacttggca tatcaccacg
     9841 attattagga tctttatcac ctgttgcata ctgctctgta ccataataaa tattaggcac
     9901 acctctagat gttaaaagca aagcataggc ttgattaaca gcagtttgat tattagccac
     9961 ttttgttgcg aagcgttcca tatcatgatt atcaataaag gtcacctggt ctgtcacttc
    10021 attagtcacc tgatctctat tttcaagaac cttgtaaaaa tctcgcatgg taaacgttga
    10081 aaaacctgta tacaactgtc taatagcatt ggcaaatcta aaatctaaaa gccccatccc
    10141 actattgtta gcaaatgtcg tcatatcata atcatcgtcg gtatgtcccg agaaccattc
    10201 cccgaaaaca aagacattat gtttttcata gatatgactc aaccaatttt tttgccaacc
    10261 ttgtgacata tgtttaacag cgtcaactcg gataccatca acacccaggt ctaaccattt
    10321 atcaatagct tctttcatgt actggtcaac tttcggatta atgttattta aatcagctag
    10381 tccgtacatt gaatgataaa tagaattttc ataagtacta aaatcggtcc aagattcatg
    10441 attaaaaatc ttgtctttat catctgaaaa tttaccaact aatttaccgt ttttatataa
    10501 agcgccatct tctttgaaag ttgtgccttc tttttcggct gtagacgtat gattaggagc
    10561 aaaatcaata actaccttaa tatggtgttg atgagctact ttgactagtt gttgaaagtc
    10621 tgcttcagtg ccaaaatgct ggtttgtttt aaagaagtcc ttagcccaat acccatgata
    10681 tgcagcactt ccattagaag gatcaatact gtcgatattt tcaacaggag aagaaatcca
    10741 aatggcagaa atccccatat ctgtcaggta accatcctta atcttggcga tgattccttg
    10801 ccaatcacct ccatggtatt ttttaaggtc atttttatca aaaacatcag tcttaccatt
    10861 attagaggta ttaccatcgt taaaacgatc tgttacaatc tgataaatcg tatctgttga
    10921 aaaatctgct ttgttggtga cagaagcatt atcggcagca gaaacagtta gtggaaatga
    10981 aattaagcca agtaaaacag cacttttcgt taataactta taagttttga tatgtaattc
    11041 tctcatcgct ttttcctttt aaaataacct tttagttact aaacacaata tatccatcct
    11101 ggagtaattg ttttttgttt ttagttaccc cattgcttgt caaaatctgt cctccttcct
    11161 taatagaata agcactctca ccattgttaa gaacaagtga aatgctttgc tcacctaagc
    11221 tgcgtttcag aatgaggcag tcttcgtcat aatcaatgct aatagctcct tcttgaagag
    11281 ctggctgttg gcgaagagca ataatcgctt ttactttgct aaagaaatcc ttgtcccgct
    11341 cagcatcatc ccaaggaaaa ccgcgacgcg aatcagggtc gtaaccccct tccattgcca
    11401 cttctgtccc ataatacaag caaggaatgc ccataaagat aaagagcaat gctaaagcag
    11461 ctaacaattt atctttggaa cccttaactt gagtgaagaa acgatgcgta tcatgagaat
    11521 ccaaaagatt caagttcatg cgattgactt gccaagtgtt tcgcatcaaa atgttgctta
    11581 atttctcagc caattgtttt gatgtcatgg tttcaaaagc aaagtaatcc aaacaggctt
    11641 tggtgaaagc ataattcatt atcccatcat actgatcccc tgccaaataa ggataggcat
    11701 catgccagtt ctccccaatt aaaatggcat ctgctttttc cgctttaacc gcctgacgga
    11761 aacgtcgcca aaaatcatga gatacttcat cagaaacatc taggcgccaa ccatcgatac
    11821 aaaattcttt aatccagtat cgcccaatct caatcagata gtcttgcacg tctctatttg
    11881 aggtattcca tttgggcata tagttacatc cagcaaaggt ttcatagttt actaggtcca
    11941 tggatgggtg ttcatcatga gtcataaacc aatcaaaaaa cttagactct ttaccgtatc
    12001 tcaagacatc ctgaaattcc acggcatcac tgctggcatg gttaaagaca gcgtctagaa
    12061 taatcttgat tcccatttgg tgagctaaat caatcaattc ttgcaaatca tatttagttc
    12121 caaattgtgg atcaatagcg tagtaatcac taatatcata tttgtgatta ctaatggatt
    12181 gaaaaattgg cgttaaatag atgacagtaa tccctaaatc tttgaggtaa tctaattttt
    12241 ctgtaattcc ctttaaatct ccaccagcaa aacttttagg agtcggtttt tctaaccaac
    12301 ccatgttgac ataactgtca cctttttccc aatccccacg gttaaagcga tcaacaaaga
    12361 tttgataaaa aaccgcgtct tttgtccaag gaatgacttg atgaacatca acagcattga
    12421 tataaggcat ttggaagaaa ttataaaacc catttgaaaa atcgtaacta gtagttaacc
    12481 catcttcact aaaataatag gtttgacctt cttcttcaat tttaaaaatg taggccaacc
    12541 tcacatcgtc taatgttaaa gtagtttcat aataagcatg cgtatggtct gtataggcaa
    12601 ctgacatttc caattcttct tggaattcat gataaccata tttaggcccg tggaccaaat
    12661 taacagtaat acctctatct tctttggcca cgcgtaatcg gatgacaagt tccttttgag
    12721 atatggcaaa gcaatacctc gaatcaggaa tatggagcat tccggcaaca ttcatttcta
    12781 cctccattaa taaagtattg acgattactt ctttttcttt aaaacgaaaa aatagcagag
    12841 cgactcatac ttctatattt ttagtatctg tttcatcttc atcaaactaa cagaaataga
    12901 agctgggcgt acttctttat cccagcctcc cttctttgcc ttattcagcg tatttttgtt
    12961 caatagcttc cttaatagtt tttgctgctt cttttgcagc tttagatgct tcttccttac
    13021 cagaagccac gttaaagaac atatttgcac ctggttccca aacttcagcc atttctggaa
    13081 tatttggcat tggttgtgcg ctctcaaact gactaatcac agctttcgtt aactcattac
    13141 cctctttaga agcatagtta cgtgctgtta agttagctgg aatttcttgt gttttatcat
    13201 agaaacgttt ttggttttca gcattggtca cataatcaag gaatttttga gcagtcgttt
    13261 ttcctttaga atagtttgaa ataacccaag ctttaccacc tgcgaacggt tggtattttt
    13321 taccatttgt caaagtagga atttccatta ccccaaagtt aacaccagca tctttaaagg
    13381 agctagctgc ccatggacca tcaataatga caccagcttt tttagaaata aattgttcag
    13441 tgataaaatc accagctttt ttagtgtctt gcattccttg aggccaagtg ccataccact
    13501 gtttcgcgta gtttaaccct tcaacagttc cgtcgttacc taggcctaaa tcacttggtt
    13561 tggttccttt atcaccaaag atataaccgc cataaccggc aattaaacca taaccataat
    13621 agaagtctgt ccatttcgcc aagaaaccta cagattttcc tggttcagag gcaaaagcaa
    13681 acttagaatc tttttgtaag acttctaatt cagtaaagct tttaggtgct tgaggcacta
    13741 aatccttatt ataataagtt accaaagttt caattacgtc tggtgcacca taagttttac
    13801 catcaatggt tactaatttc ttaaccgtat catcaaactc tttgctgttt cctaaagtaa
    13861 cctcagcgat ttgaccttca gttcctaagc cacctacacg gtcaaaaggt gctaaaaaga
    13921 catctggtga agctcctgtt ggaccatccg ttgatagctt atcaagagta tccatcatac
    13981 cttctttttt gactttaacg gtgactttat gttctttttc aaactcaccc ttaatactct
    14041 taatgtaatc aacatatccc tcatcaacag agactacaat agtctttccg tctgtttcct
    14101 taacgccttt accaccacca cttacgcaag cagttagggg tagcactgaa gctaaggata
    14161 aagttccaag cacagatgtt tttttccaat tccatgacat aacatgttcc tcccgaaatg
    14221 gttttttctt aaacacaaat caaatcatct atctactctc atcatattag caaataaaag
    14281 ataacataag gcatttaaaa ttaataacag taatagcttc gaaacttaaa cgtttaagtt
    14341 aagtttatcg taaccgcttt tatttgtcaa taactttttt acttttcttt tcttttcttt
    14401 taagatcata tcagtagttt tcctgctaat tgaaaacaag gcatttactg tcacacaagt
    14461 ctgtcctttc tttttttcta caactttatt tcgtcagcgt aaataaaaca aaagctctat
    14521 aatctcttga atgggtaaat ccactgtaga gattatagag ctttttgaat atcaaaaaag
    14581 tcccataaga tttataatga aaagcaacca aactctcatt agaaagactc ttatgaaaca
    14641 tatcaatcat accttacaac acatcggaat taaagacaaa aatatcactc taaacaatgt
    14701 tttgaaggat gaatctccta ctgagctcgt tactacttat cagaaaggta gataggaaat
    14761 cctgatgaag agtgtgtcca agggattatc aattaggtct tagattacaa aatagtaatt
    14821 caggtatgct ctactgtttt caacactagt tctacaattt gttttcgagc ttgcttagct
    14881 tctcttattg gaaaaataac atacgcatga atcatttttt ctgcaataat cagctgatta
    14941 gcaattcgtt gtcttgttaa ttgatcatgt aaagacataa tgtctgggta aaaaatctct
    15001 tttgtcccaa caaaggtcgt tatttcaggc aaatcctcat aatcaccata caaaggactg
    15061 acataaggaa gttgcatatt accttgacca cctgcccata gttcacctat atcacgaaga
    15121 cggcgagcat ctaggtaagc ttcttctgct tcaaaatcct tgtaggcttg atttttaaaa
    15181 ctaacatcta accaaggaga tataagaatt aattgctttg gctgtggtgc tgttttagta
    15241 tctcgtatat acttagcaaa cgccaaagcc atacccccac cagaagaatc accaatgaca
    15301 ctaacttgac tcggtccatt agacaagcaa aattgctggt aagcttcaac taatttagga
    15361 tagacatctt gataagtagc atacggtact ttaggaaagt taggaaaaac aagcttggca
    15421 ttagtcagct gtataagatg cttaaccgtc ttaaaatgaa gtttttcggg tcgtcgtaaa
    15481 tagacactgc cataaagata ataaataaca ggctgatgac tttgcttttg atcattaata
    15541 ataaaaactt gcatcccgtt cacatcgtat tcttgagttg aaaaacctac tatctcttca
    15601 ggattatcta gatgataagg gatattacga ttacgctgcg tctcaacccc cttataatta
    15661 tcaacttttt tagataactt atactttcta taagcaaaca ttttctcaac caaccaactt
    15721 gaaaaggagc gcttttgacc atattcaact atcaaaatac ctagtatcac tccaaaaaaa
    15781 atcaccacag caataatgac cacttattat cctcgttttc taatattatt ttactattgc
    15841 aagtctttcc tatttgccca aattttacta taaaaataag ggttcatttt atagttgggt
    15901 actggctgct tcgtttctag aaatggttgc actttcttat caaaagctaa ccagccattc
    15961 caaccgagat ggatggtatc ttgcataaag taggactcac caccatcttt tgagaagtca
    16021 gcaatgcgat gaaatccttg tgactttaac tggaatttta ttttacgaac tgccgcttga
    16081 tacttatctt gatttaagcc ggtataatcc gcccaagctt tattaacagg agttataaca
    16141 aagagtacat ctgtttttcg tttagcaaat tctgataaca aaagctgaaa atcattgtat
    16201 tctggtgacg ccaggtaact ataattaact tggaaattct tataaagatt gtatttaggt
    16261 gctattcgtt tacgataaaa tgtattttta atcccaaaac ggttgttggt tgttgctaat
    16321 tggcctctct tagttgctaa cgcattcaat tgtttatacg aaaatacttt aggtaatccc
    16381 ttaacgcgag gcaaaattct tttttcatag ttagtagatt tgcctaaaaa actaaaaagg
    16441 gactcttctc tcaatgctac ttgatgttga catttcaaaa tagctctgtc taaccgacta
    16501 agagacttac ccttacttac ttttttcaat aagtttgatt tagacacacc agggttaagc
    16561 tcaagcaaac gctttgctgc aaactgtgat tctttatcag ttctagcttt tagtaaaaat
    16621 tcaatcactt gagtgttaga caagtacatc tgaaccgcac taggattaat cccttgagca
    16681 gtaaaccatt gaggagatac tacaaagatg gcttttttct tttgcatttc attggtaatt
    16741 tgttgcatac cataataatg cgacaaagat gctgatcctc tcttaccaat taaaaatggt
    16801 ctatagctcc gcttgtagcg ctctgcaagc accgaagggt gcatactatc cattcgactc
    16861 cattcgctag aaccaaaaaa aggcacaaaa cgacaagtct catctgataa agcttgtctt
    16921 ttaatcaaac catttttaaa agaactatct gtgatcgcaa cggcatttgc tttttcctga
    16981 gctatggaat gatcaagttg tgtaggaaaa ctaaaaatag taatcactac taaaacaaag
    17041 gcaataagaa gaggacctag aattaaccag agtctcttaa gcatgttgca attcctctac
    17101 accttgaaca atcttagtta ctgtgttcca atcatcacga ccaaattctg aaataggtac
    17161 tttaatattg aacgttgact ctaactcaac aatcaattcg actgtcccaa gactatccaa
    17221 cacacctgca tcaaacaagt cttcgtccat catctctgaa acatcttcca taaacaaacg
    17281 gtcaaacaat tcaattacag tttcttcaat agacattttt atacttcctt ttattaatgt
    17341 agtggtctgt taaaccaaag gtcatttaaa aaaccagaga ataacagaag tgaaaacatg
    17401 acaacgtgga aagttaccac gatacataag acatggaatg ccctgctttg aaagaggggt
    17461 gataagcctt ttttcttacg gtgacggttg atttcttttt tcttacgaat ccaagcatca
    17521 ttaataataa gtcctatacc atggaaaagc ccataagcga tataatacca ggttaagcca
    17581 tgccaaaatc ccatgactag catattaacc agataggcaa cacctgaagt gacatttcgg
    17641 tttttaaagg ttttatgctt aatcaataga tgaaccaatc gcataaacac ataatctcta
    17701 aaccagaagg acaaactcat gtgccatcta ttccaaaaat ctttcaagct tgcagataag
    17761 aaaggcatgt taaagttttc tggtgttcga atacccaata ggtaggaaat accaatcgca
    17821 aacatcgaat aaccagcaaa gtcaaaaaag agattcaagc catacacgta cataaccaga
    17881 atagtttcct tattaaagta gccaccaacc atcaaagcct tattttcaag gagaggaagt
    17941 aagatgccac ccaaacaata ggaaatgata tgcttgtata ggaaacctaa catgagatac
    18001 atgactgcct tattgagcat tgcaaaataa tcatcacgtt caggaagttt atgataatct
    18061 tcctgaaaac gtctgaagcg atcaatgggg ccacttgaga aagtggggaa gaaaatcatg
    18121 aagcgaataa aatccggtaa acgaacctct tggagagtcc cgtcacgcat ctcaataatc
    18181 attccaatac ttttaaaggt caaatatgaa atccctagaa aactaaagag tgtttgagaa
    18241 gaaggacctg ttaggggagc aactttgacc cagataaggg ggaataaggc catcgcaata
    18301 gctaagtaaa acactcctgc actattagct ttctcacggt atttctggta agcaaaaaca
    18361 ctgatgattt gccacaaaag ataaaagaga aaagcaacta attgttgata atgatctcct
    18421 ccaaacataa agagaataaa taccaaactc accaaggttt cataagtgct taagcgcttt
    18481 tgtttaaaaa tcccaatgat gactggtaag aaagccaaaa taagatagac aaagtaaatg
    18541 gggttaccgt aaggttccat gtagggaatg tggctaaaaa acatcatcat cggttattga
    18601 cctcattaat caaagtttta atatctatct taccatttgg agtcaatggt agactgtctc
    18661 gataaagaaa cttagaaggc atcatataac tcatcatatg atccttaaca gaggctttga
    18721 tagctttggt taactccaat tccctatcaa aacgctcttt aaccccatct ttgacaacga
    18781 tataggccaa gagattttga accttatgtt ctttattgta ccttggaaca gccacagccg
    18841 atgctaccat tggtgattga ttcaactgtt gggaaacatc ttctagttca atacgataac
    18901 cagcatattt aatctgaaaa tccaaacgcc caccatacag caaaatatta tcttctgtca
    18961 gtgagccaat gtcccctgta tgataagcag gctgtccttt aaaagtaaag aaagcttctg
    19021 cggttttctc aggattgttg aggtaacctt ttgacacagc aggccctgta acaataattt
    19081 caccctgctc ccctgaagct aactccttac catcttcatc aataatatag gtcggagaat
    19141 ctggtttggg gtagccaatc ggcaagcggg tataattatc caccatttct ctggtaattt
    19201 caatagcgga taaggctaca gtcgcttctg ttggtccata ggcattgata atcttggcac
    19261 tcgggaaacg ttcaaagagt tttcgagccg tagaaacggt taattcttcg ccatcaaaat
    19321 aaaaatgcgt taaagctggc atcctagcct ggcaaaaatc atcgctaagc atggccatat
    19381 cagcaaatga aggagtcgat gtccaaatgc caactggaag ttgcgcaatc gttgtaaata
    19441 actgtttaaa gtctgccacc aattcttttg gaagtgcaaa taaggttcca cctaaagcca
    19501 aggtaggtgc ccagtacatg acagaaaggt caaaggaata gggtggctgc gccagcattt
    19561 gtggctgttt aggtacatca aatgctgcat cttcgatcat ccagttggta aagctcaaaa
    19621 gattgtcatg tgaaatttgc accccttttg gttggcccgt tgttccagag gtgaaaataa
    19681 tgtaataatt atcatctcct ttaacagaat gtgttcgctc atagggcatt tctgctaatt
    19741 ttgctgactc aatctctgat agtgagacaa gggaaatccc ttcaatagta agagggaatt
    19801 cctcaatagc aatgattaaa ctgggctttg caatctcaat aatcgctaaa atacgttctg
    19861 gtgctgaatg cacatctact gggatatagg catgaccaga tttggttaaa gctacaaaag
    19921 tagctaacat atcataagtt tgcgccccaa aaaccaaaac tggagatttt gccagtaaag
    19981 ctaagctatc tataaatgca gcaatgctat cagaatctct tttgagttgt ccgtaagttc
    20041 ggcgttcccc taaacaatca taaactggga aatcagcctg tgtctgagca aactgctcaa
    20101 tactgtcaat catatcctta atcatcagtc aatctcctaa aattcattat aaataaagtt
    20161 actttgacca tgtcctagat aaccaaagaa atagaccagc aacattaaaa tcagataaaa
    20221 taaaattgtc ttgccaataa aaacagcaat tcctctcatt cttgatttgt tttttatcat
    20281 actttacctt cttgtattag tgaaataatg tcctaaaaaa ttctactcga aaaaac
//
LOCUS       DAUDWO010000035        20094 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.035, whole genome shotgun sequence.
ACCESSION   DAUDWO010000035 DAUDWO010000000
VERSION     DAUDWO010000035.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20094)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20094)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20094
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.035"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(106..1551)
                     /locus_tag="VHC05_001328"
     CDS             complement(106..1551)
                     /locus_tag="VHC05_001328"
                     /EC_number="6.3.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-
                     lysine ligase"
                     /protein_id="HEQ5402629.1"
                     /translation="MITIEQLLDILKKDHNFREVLDADGYHYHYQGLSFERLSYDSRQ
                     VDGKTLFFAKGATFKADYLKEAITNGLQLYISEVDYELGIPVVLVTDIKKAMSLIAMA
                     FYGNPQEKLKLLAFTGTKGKTTAAYFAYHMLKESYKPAMFSTMNTTLDGKTFFKSQLT
                     TPESLDLFAMMAECVTNGMTHLIMEVSSQAYLVDRVYGLTFDVGVFLNISPDHIGPIE
                     HPTFEDYFYHKRLLMENSRAVVINSGMDHFSFLADQVADQEHVFYGPLSDNQITTSQA
                     FSFEAKGQLAGHYDIQLIGHFNQENAMAAGLACLRLGASLADIQKGIAKTRVPGRMEV
                     LTMTNHAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIH
                     QHPNLTVILTADDPNFEDPEDISQEIASHIARPVEIISDREQAIQKAMSLCQEAKDAV
                     IIAGKGADAYQIVKGQQVAYAGDLAIATHYL"
     gene            1639..3273
                     /locus_tag="VHC05_001329"
     CDS             1639..3273
                     /locus_tag="VHC05_001329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HEQ5402630.1"
                     /translation="MSTEKKQLTQEELMVQGAAWSTAGNFISRLLGVLYIIPWYIWMG
                     QYAIQANALFNMGYNVYAYFLLISTTGLNVAIAKQVAKYNSMGQTEHSYQLIRSTLKL
                     MLGLGLIFSAIMYLGSPLFASLSGGDDTLVPIMHSLSLAVFIFPVMSVIRGIFQGHNN
                     IKPYAMSQIAEQLIRVIWMLLTTFFIMKLGSKDYLSAVTQSTLAAFVGMIASMAVLGY
                     YLWKLGLLKAICRKPNHHIDSDIKGLLLETLKESIPFIVTGSAIQAFQLIDQWTFVNT
                     MTLFTDYSRSQLLVLFGYFNANPAKITMVLIAVAASIGGVGIALLTENYVKKDMKAAA
                     RLIINNIEMLVMFLLPALTGAIILARPLYSVFYGASEDRAIHLFVAVLFQTLLMALYT
                     LFSPMLQALFENRKAIYYFVYGILIKLVLQIPLIYLLHAYGPLLATTIALVVPIYLMY
                     RRLYQVTHFNRKLLQKRLLLTLIETLLMGLVVFVANWLLGYAFKPTGRLTSLLYLLII
                     GGVGMTAYTALTLLTHQLDKLIGSKASRLRQKLGWH"
     gene            3441..4070
                     /gene="upp"
                     /locus_tag="VHC05_001330"
     CDS             3441..4070
                     /gene="upp"
                     /locus_tag="VHC05_001330"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002883819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="HEQ5402631.1"
                     /translation="MGKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEV
                     SRDLPLEDVDIQTPVSKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGM
                     YRNEETLEPVEYLVKLPEDINQRQIFLVDPMLATGGSAILAVDSLKKRGAANIKFVCL
                     VAAPEGVKKLQEAHPDIDIFTAALDDHLNEHGYIVPGLGDAGDRLFGTK"
     gene            4294..4884
                     /locus_tag="VHC05_001331"
     CDS             4294..4884
                     /locus_tag="VHC05_001331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002937303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease proteolytic subunit"
                     /protein_id="HEQ5402632.1"
                     /translation="MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIA
                     QLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIA
                     SSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
                     TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK"
     gene            5379..5672
                     /locus_tag="VHC05_001332"
     CDS             5379..5672
                     /locus_tag="VHC05_001332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbG family protein"
                     /protein_id="HEQ5402633.1"
                     /translation="MFQKQERIGLVVYLYYNRDARKLSKFGDLYYHSKRSRYLIIYIN
                     KNDLDTKLEEMRRLKCVKDIRPSAFDDIDRQFVGNLHRDETNNHQKGYQPPSY"
     gene            5903..6538
                     /locus_tag="VHC05_001333"
     CDS             5903..6538
                     /locus_tag="VHC05_001333"
                     /EC_number="2.7.4.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTMP kinase"
                     /protein_id="HEQ5402634.1"
                     /translation="MITGKLITVEGPDGAGKTTVLEQLIPLLKQKVAQEILTTREPGG
                     VAISEYIRELILDINHTTMDPKTELLLYIAARRQHLVEKVLPALEAGRLVFIDRFIDS
                     SVAYQGAGRGLIKADIQWLNEFATDGLEPDLTLYFDVPSEIGLARINANQQREVNRLD
                     LETIEIHQRVRKGYLALAKEHPKRIVTIDATKPLKEVVSVALEHVLALLLA"
     gene            6556..7431
                     /locus_tag="VHC05_001334"
     CDS             6556..7431
                     /locus_tag="VHC05_001334"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="HEQ5402635.1"
                     /translation="MDLAQKAPNVYQAFQTILKKDRLNHAYLFSGDFANEEMALFLAK
                     VIFCEQKKDQTPCGHCRSCQLIEQGDFADVTVLEPTGQVIKTDVVKEMMANFSQTGYE
                     NKRQVFIIKDCDKMHTNAANSLLKYIEEPQGEAYMFLLTNDDNKVLPTIKSRTQVFQF
                     PKNEAYLYQLAQEKGLLNHQAKLVAKLATNTSHLERLLQTSKLLELITQAERFVSIWL
                     KDQLQAYLALNRLVQLATEKEEQDLVLTLLTLLLARERAQTPLTQLEAVYQARLMWQS
                     NVNFQNTLEYMVMSE"
     gene            7450..7689
                     /locus_tag="VHC05_001335"
     CDS             7450..7689
                     /locus_tag="VHC05_001335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tpl protein"
                     /protein_id="HEQ5402636.1"
                     /translation="MGKRSLSKDLPVATKVAAHRGKKAFEENTAFATDLMKEVSRLIT
                     QNKLEMTFINSVFLLDQHVVLIPFSAEEHMDFYNC"
     gene            8093..8416
                     /gene="yabA"
                     /locus_tag="VHC05_001336"
     CDS             8093..8416
                     /gene="yabA"
                     /locus_tag="VHC05_001336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication initiation control protein YabA"
                     /protein_id="HEQ5402637.1"
                     /translation="MNKKELFDAFDGFSQNLMVTLAEIEAMKKQVQSLVEENTILRLE
                     NTKLRERLSHLEHETVAKNPSKQRKDHLEGIYDEGFHICNFFYGQRRENDEECMFCRE
                     LLDRK"
     gene            8421..9284
                     /gene="rsmI"
                     /locus_tag="VHC05_001337"
     CDS             8421..9284
                     /gene="rsmI"
                     /locus_tag="VHC05_001337"
                     /EC_number="2.1.1.198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="HEQ5402638.1"
                     /translation="MQVQKSFKDKKTSGTLYLVPTPIGNLQDMTFRAVATLKEVDFIC
                     AEDTRNTGLLLKHFDIATKQISFHEHNAYEKIPDLIDLLISGRSLAQVSDAGMPSISD
                     PGHDLVKAAIDSDIAVVALPGASAGITALIASGLAPQPHVFYGFLPRKAGQQKAFFED
                     KHHYPETQMFYESPYRIKDTLTNMLACYGDRQVVLVRELTKLFEEYQRGSILEILSYL
                     EETPLKGECLLIVAGAQVDSEVELTADVDLVSLVQKEIQAGAKPNQAIKTIAKAYQVN
                     RQELYQQFHDL"
     gene            9311..9703
                     /locus_tag="VHC05_001338"
     CDS             9311..9703
                     /locus_tag="VHC05_001338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003058684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402639.1"
                     /translation="MTEDQATILILGVYGIILAVFLLSALLCLIANWRLFKRAGYKGW
                     YSLIPFYAGFVKHKITFGEDNKWFYFIGWVIAIYYYYVHFCYVRAFGGSKGLAVFGLF
                     FPGIASLIVAFGKTYTTQECHPVPHLLN"
     gene            complement(9750..10379)
                     /locus_tag="VHC05_001339"
     CDS             complement(9750..10379)
                     /locus_tag="VHC05_001339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper homeostasis protein CutC"
                     /protein_id="HEQ5402640.1"
                     /translation="MIKEFCAENLTLLPTLDAGQVSRVELCDNLAVGGTTPSYGVIKE
                     ACQLLHDKKISVATMIRPRGGDFVYNDLELKAMEEDILKAVEAGSDALVLGLLTTENQ
                     LDTDAIEQLLPATQGLPLVFHMAFDRIPTDHQHQALDQLIDYGFVRVLTHGSPEATPI
                     TDNVEQLKSLVTYANKRIEIMIGGGVTAENCQSLSQLTGTAIVHGTKII"
     gene            10679..11035
                     /locus_tag="VHC05_001340"
     CDS             10679..11035
                     /locus_tag="VHC05_001340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HEQ5402641.1"
                     /translation="MITIYQYPKCSTCQRAMAELKQLVSDFEAIDIKANPPKAQDLKH
                     WMETSGYTIKNFFNTSGNSYRELGLKDKIDQLSLDKAAELLATDGMLIKRPILIKDGK
                     VLQVGYRKPYQELDLG"
     gene            complement(11109..11936)
                     /gene="xth"
                     /locus_tag="VHC05_001341"
     CDS             complement(11109..11936)
                     /gene="xth"
                     /locus_tag="VHC05_001341"
                     /EC_number="3.1.11.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III"
                     /protein_id="HEQ5402642.1"
                     /translation="MKLISWNIDSLNAALTGESPRALLSRAVLDTLVAQDADIIAIQE
                     TKLSAKGPTKKHIETLLSYFPNYLHVWRSSVEPARKGYAGTMFLYKNTLNPVITFPEI
                     GAPTTMDAEGRIITLEFEDFFVTQVYTPNAGDGLRRLDDRQIWDHKYADYLTELDTQK
                     PVLATGDYNVAHKEIDLANPSSNRRSPGFTDEERQGFTNLLARGFTDTFRHLHGDIPH
                     VYTWWAQRSKTSKINNTGWRIDYWLASNRIVDKIKRSEMISSGERQDHTPILLDIDL"
     gene            12170..13351
                     /gene="lctO"
                     /locus_tag="VHC05_001342"
     CDS             12170..13351
                     /gene="lctO"
                     /locus_tag="VHC05_001342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate oxidase"
                     /protein_id="HEQ5402643.1"
                     /translation="MAQKTVITEETTDFVMDFKTSSAEGNVDFINVFDLEKMAQQVIP
                     KGAFGYIASGAGDTFTLHENIRSFNHKLIVPHSLKGVENPSTEITFDGDHLTSPLILA
                     PVAAHKLANEQGEVASAKGLKEFGSIYTTSSYSTTDLPEISAALGETPHWFQFYYSKD
                     DGINRNIMDRVKAQGCKAIVLTADATVGGNREVDRRNGFVFPVGMPIVQEYLPDGAGK
                     TMDYVYKSAKQALTSKDIEYIATYSGLPVYVKGPQCAEDTLRALDAGASGIWVTNHGG
                     RQLDGGPAAFDSLQEVAEAVDQKVPIVFDSGIRRGQHIFKALASGADLVALGRPAIYG
                     LAMGGSIGTRQVFEKLNDELKMVMQLAGTQTIQDVKAFNLRHNPYDSSIPFDQNALRL
                     D"
     gene            13617..18560
                     /gene="scpC"
                     /locus_tag="VHC05_001343"
     CDS             13617..18560
                     /gene="scpC"
                     /locus_tag="VHC05_001343"
                     /EC_number="3.4.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CXC chemokine-degrading serine protease SpyCEP"
                     /protein_id="HEQ5402644.1"
                     /translation="MEKKQRFSLRKYKSGTFSVLIGSVFLMMMTTTTVAADELTTTSE
                     PTITNHAQQQAQHLTNTELSSAESQSPDTSQITPKTNREKEQPQGLVSEPTTTELADT
                     DAASMANTGPDATQKSASLPPVNTDVHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAH
                     QSMRISDVSTAKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQFGD
                     FDEDWENFEFDAEPKAIKKNKIYRPQSTQAPKETVIKTEETDGSHDIDWTQTDDDTKY
                     ESHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDVMGSAESLFIKAIED
                     AVALGADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVVAAGNERVYGSDHDDP
                     LATNPDYGLVGSPSTGRTPTSVAAINSKWVIQRLMTAKELENRADLNHGKAIYSESVD
                     FKNIKDSLGYDKSHQFAYVKESTDAGYKAQDVKDKIALIERDPNKTYDEMIALAKKHG
                     ALGVLIFNNKPGQSNRSMRLTANGMGIPSAFISHEFGKAMSQLNGNGTGSLEFDSVVS
                     KAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGDIYSTYNDNHYGSQTGTSMASPQIA
                     GASLLVKQYLEKTQPNLPKEKIADIVKNLLMSNAQIHVNPETKTTTSPRQQGAGLLNI
                     DGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTVHNLSNKDKTLRYDTELLTDHVDPQ
                     KGRFTLTSRSLKTYQGGEVTVPANGKVTVRVTMDVSQFTKELTKQMPNGYYLEGFVRF
                     RDSQDDQLNRVNIPFVGFKGQFENLAVAEESIYRLKSQGKTGFYFDESGPKDDIYVGK
                     HFTGLVTLGSETNVSTKTISDNGLHTLGTFKNADGKFILEKNAQGNPVLAISPNGDNN
                     QDFAAFKGVFLRKYQGLKASVYHASDKEHKNPLWVSPESFKGDKNFNSDIRFAKSTTL
                     LGTAFSGKSLTGAELPDGYYHYVVSYYPDVVGAKRQEMTFDMILDRQKPVLSQATFDP
                     ETNRFKPEPLKDRGLAGVRKDSVFYLERKDNKPYTVTINDSYKYVSVEDNKTFVERQA
                     DGSFILPLDKAKLGDFYYMVEDFAGNVAIAKLGDHLPQTLGKTPIKLKLTDGNYQTKE
                     TLKDNLEMTQSDTGLVTNQAQLAVVHRNQPQSQLTKMNQDFFISPNEDGNKDFVAFKG
                     LKNNVYNDLTVNVYAKDDHQKQTPIWSSQAGASASAIESTAWYGITARGSKVMPGDYQ
                     YVVTYRDEHGKEHQKQYTISVNDKKPMITQGRFDTINGVDHFTPDKTKALGSSGIVRE
                     EVFYLAKKNGRKFDVTEGKDGITVSDNKVYIPKNPDGSYTISKRDGVTLSDYYYLVED
                     RAGNVSFATLRDLKAVGKDKAVVNFGLDLPVPEDKQIVNFTYLVRDADGKPIENLEYY
                     NNSGNSLILPYGKYTVELLTYDTNAAKLESDKIVSFTLSADNNFQQVTFKMTMLATSQ
                     ITAHFDHLLPEGSRVSLKTAQGQLIPLEQSLYVPKAYGKTVQEDTYEVVVSLPKGYRI
                     EGNTKVNALPNEVHELSLRLVKVGDASDSTGDHKVMSKNNSQALTVSATPTKTTTSAT
                     AKALPSAGEKMGLKLRIVGLVLLGLTCVFSRKKSTKD"
     gene            19332..20039
                     /locus_tag="VHC05_001344"
     CDS             19332..20039
                     /locus_tag="VHC05_001344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1275 domain-containing protein"
                     /protein_id="HEQ5402645.1"
                     /translation="MSKKKRKHYQVYEGLRCAMTLCFISGYVNAFTYMTQGKRFAGVQ
                     TGNLLSFAIRLSEQQLKEALQFLLPMIVFMLGQSFTYFMHRWATKKRLHWYLLSSVML
                     TGLAFGTALFTPFLPSNVTVAALAFFASIQVDTFKTLRGASYANVMMTGNIKNAAYLL
                     TKGLYEKNHELTHIGRNTLIVILAFAVGVVCSTLLCIAYGEYALMPILMPLLYVNYLL
                     AQEFYHIQTKIKPIKRT"
BASE COUNT         6409 a         3934 c         4137 g         5614 t
ORIGIN      
        1 aaagcctttt ttgatgtgat ttttaggatg tattaaaaaa gaaatattag tttagaatga
       61 ttaaaaacaa tagcgagaat cattctaaag taacgtcaac atactctaga ggtagtgtgt
      121 ggcgattgct aaatcaccag cataagctac ttgttgtcct ttaacaattt gataagcatc
      181 tgcgcctttc ccagcgataa tcacagcatc ttttgcttct tggcaaagag acatggcttt
      241 ttgaatagct tgctcacggt cactaataat ctctaccggg cgtgcgatat ggctggcaat
      301 ttcctgcgaa atatcttctg gatcctcgaa attagggtca tcagcagtga gaatgacggt
      361 gaggtttgga tgctgatgaa tcaccctacc aaaatcagct cgtctgctct cgcctttatt
      421 tcctggtgca cctaaaatca acattaattt gcctgtctga tgttcttcca caacgctgag
      481 taatttttct aagctgtcac cattatgggc ataatcaaca aaaactttag catgatttgt
      541 catagtgagg acttccatac ggcctgggac gcgagtctta gcgatacctt tttgaatatc
      601 agctaggcta gcacccaaac gaaggcaggc aagtccagct gccatagcat tttcttggtt
      661 aaaatggcca attaattgaa tgtcataatg gccagctaat tgtcctttag cttcaaagga
      721 gaaggcttgg ctagtggtga tctggttgtc agacaaggga ccataaaaca catgctcttg
      781 atccgctacc tgatcagcta gaaatgaaaa atgatccatc ccgctattga tcacaacagc
      841 tctgctattc tccattaaaa gacgcttatg atagaaataa tcttcaaacg ttggatgctc
      901 gattgggcca atatgatcag gactaatatt taggaaaacc ccaacatcga acgtaagccc
      961 atagacacgg tcaacgaggt aagcctgact agaaacttcc ataatcaagt gggtcatgcc
     1021 attagtcaca cactcagcca tcatagcaaa aagatccaag ctttcaggag ttgtaagttg
     1081 tgatttgaaa aaggtcttgc catctaaggt ggtattcatg gtagaaaaca tggcaggttt
     1141 ataggattct ttcaacatgt ggtaggcaaa ataagcagcc gtcgtctttc ccttagtacc
     1201 tgtaaaagct agtagtttga gtttttcttg agggttgcca tagaaagcca tggcaattag
     1261 actcatagct tttttgatat cagtgaccaa aacaacggga ataccaagct cgtaatctac
     1321 ctctgaaata tagagttgta atccgttagt gattgcttct ttaaggtagt cagctttgaa
     1381 agttgcccct ttagcaaaaa aaagggtctt gccatctact tgacggctat cgtaactcaa
     1441 gcgctcaaaa cttaagcctt gataatggta gtggtatccg tcggcatcaa gaacctcacg
     1501 aaaattatgg tcttttttta aaatgtctaa taattgttca atggttatca tacccttatt
     1561 ttatccttaa agttcttgtt ttacaagtca caagcaaaag tttataataa aactaataga
     1621 aactaggaaa gaatagatat gtcgacagaa aaaaaacaac tgacacaaga agaattgatg
     1681 gttcagggag cagcctggtc cacagctggt aatttcatta gccgactttt gggagtgtta
     1741 tacattattc cctggtatat ttggatgggg caatacgcga ttcaagccaa cgctcttttc
     1801 aatatggggt ataatgttta tgcttatttt ttattgattt caaccacagg actcaatgtt
     1861 gcgattgcta agcaggttgc caagtacaat tccatgggac aaactgagca tagctatcaa
     1921 ttaatccgaa gtaccctaaa actcatgctt ggtctgggcc ttattttttc agccattatg
     1981 tatctgggtt ctcctttatt tgcgagctta tctggtggtg atgacacact tgttcccatt
     2041 atgcacagcc tttctttagc agtttttatt tttcctgtaa tgagtgtgat tcgaggtatc
     2101 tttcaaggcc acaataatat caagccttat gcgatgagtc agattgctga gcaactcatt
     2161 cgggttatct ggatgctttt gaccaccttt tttatcatga agttaggttc aaaagattat
     2221 ctatcggcgg taacgcagtc aaccttggca gcctttgtgg gaatgattgc tagtatggct
     2281 gtcttaggtt actacttgtg gaagttaggc ttgctaaaag caatatgtcg taagcccaat
     2341 catcatattg atagtgacat taaaggactg ttgcttgaaa cattaaaaga gtctattccg
     2401 tttatcgtaa caggaagtgc cattcaagcc tttcaattga ttgatcaatg gacttttgtc
     2461 aatactatga ctctttttac agattatagc cgttctcaat tgcttgtttt atttggttac
     2521 tttaacgcaa acccagccaa aattacaatg gttttaattg cagtagcagc atctattggt
     2581 ggtgtaggca ttgccttatt aactgaaaat tatgtcaaaa aagacatgaa agcagctgct
     2641 cgcttaatca ttaacaacat tgaaatgtta gtgatgtttt tgttacccgc tcttactggg
     2701 gcaattattt tagcaagacc tctatattcc gttttttacg gagctagcga ggatcgtgcc
     2761 attcacctct ttgtggcggt cctcttccaa accttgttga tggcgcttta tacccttttt
     2821 tcaccgatgc ttcaagctct ttttgaaaat cgaaaagcga tttactactt tgtttatggt
     2881 atcttgatta agttagtttt acagataccg cttatttatt tgctacatgc ttatggtcct
     2941 ttactagcga cgacgattgc tttagtggtg ccgatttatt tgatgtatcg acgcctatat
     3001 caggttactc attttaaccg caaactgttg caaaaacgtt tattattaac cttgattgaa
     3061 accttattaa tgggactggt cgtgtttgtg gccaactggc tattgggcta tgcctttaaa
     3121 ccgacaggcc gcttgaccag ccttctttat ctcctcatta ttggtggcgt gggaatgacg
     3181 gcttacacgg cactcacctt gctgacgcat caactagata aattaattgg tagcaaagct
     3241 agtcgccttc gtcagaaatt aggctggcat taatataatg acaccaagaa cgatttcgtg
     3301 agtgcttatc gaaatcgttt ttttcttaat gatctcgctt agtaaaggta gctgataaaa
     3361 aatcaggatt tcccaagcaa actactgata tttttggtat aatgataaaa gtgtaaaaaa
     3421 atagaaggaa gtatatcaac atgggaaaat gtcaagttat ttcgcatccg cttatccaac
     3481 acaaactttc aatcttacgt cgtcaaacca catcaactaa agattttcgt gagttggtta
     3541 atgaaattgc gatgctgatg ggatatgaag tgtcacgcga ccttccctta gaagatgtcg
     3601 atatccaaac gccagtctca aaaacggtcc aaaaacagtt agctggtaaa aaattagcta
     3661 ttgttccgat tcttcgtgct ggtattggga tggttgatgg cttgttaagt ttggtaccag
     3721 ctgcaaaagt tggccatatc ggcatgtacc gtaatgaaga aacccttgaa cctgttgaat
     3781 acctcgttaa actaccagaa gatattaacc aacgacaaat tttccttgtt gatccaatgt
     3841 tggcaacagg tggttcggct atcttagcag tggattcgtt gaaaaaacgt ggcgcagcaa
     3901 atattaagtt tgtctgttta gttgcagcac cagaaggggt gaaaaaactt caagaagctc
     3961 atccagatat tgatatcttc acagcagcac ttgatgatca tttaaatgaa catggctata
     4021 tcgtgccagg cttgggcgat gctggtgatc gtttatttgg gacaaaataa aagagacaac
     4081 catcaaatag tagtcttttt aggccaatcg ttcttgattt tgttaaaaaa atcagagaga
     4141 tttctcttct ttaaaggaaa agcaagttta tgatttgacc tttattgacc aaaatattat
     4201 aataaagaca atcagtaaaa aagagatgac ctagtgggtt gccgtctctc aaaatgacgc
     4261 tactaaaaac ccttgtagat tggagaatgt attatgattc ctgttgttat tgaacaaact
     4321 agccgtggag aacgttctta tgacatttat tcacgtttat taaaagaccg tattatcatg
     4381 ttaacagggc ctgtcgaaga caacatggcc aactctgtca tagcgcagct cttattcctt
     4441 gacgcgcaag acaacactaa agatatctac ctatatgtca acacaccagg tggctctgtc
     4501 tcagcaggct tggctattgt cgataccatg aactttatca aggccgatgt gcaaactatt
     4561 gtcatgggta tggcagcttc tatggggaca gtcattgctt catcaggaac aaaaggcaaa
     4621 cgctttatgt taccaaatgc agagtatatg atccaccagc caatgggtgg cacaggcggt
     4681 ggcacgcaac aaacggatat ggctatcgca gcagaacatc tcttaaaaac acgtcaccgt
     4741 ttagaaaaaa tcttagcgca aaatgctgga aaaacgatta aacaaatcca taaagatgct
     4801 gagcgtgatt attggatgag tgctgaagaa accttggctt acggtttcat tgatgaaatc
     4861 atggaaaaca acgaactaaa ataaagagga tctctgcaaa agtattctag aaacttctag
     4921 gatgcttttt ctcttagaaa ggaaaataat gatacagcct actgcattaa aacagcttca
     4981 agagttaaaa cgtcagttca gatccctttg caaccaatta tgagatagtt tgaggatgat
     5041 ccttagcagc tgtgtgcaag aagttatgac gatttcataa aggatgacct agccagtctt
     5101 tcttcgtctc ttttacttaa agtgtggtat aatcagatta tgctagccac aactaaaaaa
     5161 tgcattgcca ttaaaggtgt tgtagatcgg cttatcctag atctcataac aatgctgtag
     5221 taccgccctt accttgctac taaagacgct gttgaagcac aaattgactt gcaaaggatc
     5281 ttgactgata ggtacatgtc cggtggaatc gccaaagcag caaaaagacc aagaccctta
     5341 tttggtctct accaaaatat aatagaaaag gatttagaat gtttcaaaaa caagaacgta
     5401 ttggactcgt cgtttacctg tattataacc gagatgccag aaagttatca aaatttggtg
     5461 atttatatta ccattccaag cgctctcgtt acctcattat ttatattaat aaaaatgatt
     5521 tagacacaaa attagaagaa atgagacgtt tgaaatgtgt taaagacatt agaccatcag
     5581 cttttgatga tattgaccgc caatttgtag gtaaccttca tcgcgacgaa acaaacaacc
     5641 atcaaaaggg ttaccaaccc cctagttact gattagcgtt tcagatttag ttagcttatt
     5701 aaagtaagaa ggttttgaca gatgctcaca ctacttcaag acaatgagac aactagagca
     5761 ttagtgaata actgagttga ctgtcacttc tttaataaga acggatagga ttggtcctaa
     5821 aatagagcac tgcaaagata tgccagtgct ttttagctca ttttttgata aaatagaact
     5881 actaaaaagt gaaggaaata agatgatcac aggaaaactc ataaccgttg aaggtccaga
     5941 tggcgcaggg aaaacgactg ttttagagca actcattcca ctgttaaaac aaaaagtggc
     6001 tcaggagatc ttgacaacaa gagagcctgg aggtgttgcc atttcagaat atattagaga
     6061 acttatttta gacatcaacc atactactat ggaccctaaa acagaactct tactttatat
     6121 tgcggctcga aggcagcatt tggtagaaaa ggtactacca gctcttgaag caggccggtt
     6181 ggtttttatt gatcgtttca tcgatagttc agtagcttat caaggtgcgg gacgcggttt
     6241 gatcaaagca gacattcagt ggctcaacga gttcgcaaca gatggtttag agcctgactt
     6301 gaccctttat tttgatgttc cttctgaaat tggtttagca cggattaacg cgaaccaaca
     6361 aagagaagtc aatcgtttag atttggaaac aatagagata catcaacgag tacgaaaagg
     6421 atacctagcc ttagctaagg agcatccaaa acgtattgtc acaattgatg cgactaaacc
     6481 attgaaagaa gttgtctctg tcgctttgga acatgtctta gccttgcttt tagcctagga
     6541 taagggaggg taggaatgga tttagcgcaa aaagctccta acgtttatca agcttttcag
     6601 acgattttaa agaaagaccg tctgaatcat gcttatcttt tttcgggtga ttttgctaat
     6661 gaagaaatgg ctcttttttt agctaaggtc atcttttgtg aacagaaaaa ggatcagacg
     6721 ccctgcgggc attgtcgctc ttgtcaattg attgaacaag gagattttgc cgatgtgacg
     6781 gtattggaac caacagggca agtgattaaa acggatgtgg tcaaagaaat gatggctaac
     6841 ttttctcaga caggatatga aaacaaacga caagttttta ttatcaaaga ttgtgacaaa
     6901 atgcatacca atgccgctaa tagcttgcta aagtatattg aggagcctca gggagaagct
     6961 tacatgtttt tgctgaccaa tgatgataac aaagtgcttc cgaccattaa aagtcggaca
     7021 caggtttttc agtttcctaa aaacgaagcc tatctttacc aattggcaca agaaaaggga
     7081 ttattaaacc atcaggctaa gctagtagcc aaacttgcca caaacaccag tcatctagaa
     7141 cgtctgttgc aaacgagcaa gcttttagaa ctgataactc aagcagagcg ttttgtatct
     7201 atttggctga aagatcagtt gcaggcatat ttagcgttga accgtctggt acagttagca
     7261 actgaaaaag aagaacaaga tttagttttg acccttttga ccttgctctt ggcaagagag
     7321 cgtgcgcaaa cgcctttgac acaattggag gctgtttatc aggctaggct catgtggcag
     7381 agcaatgtta attttcaaaa cacattagaa tatatggtga tgtcagaata agtgcaattg
     7441 gaattcgtta tggggaaacg aagcttgtca aaagacttgc ccgtagcgac caaagtagcg
     7501 gcgcataggg gcaaaaaagc ttttgaagaa aatactgcct ttgcaacaga tttgatgaaa
     7561 gaagtatcac gattaataac acaaaataaa cttgaaatga cgtttattaa tagtgtcttt
     7621 ctcttagatc agcatgttgt cctaattccc ttttcagcag aagagcacat ggatttttac
     7681 aactgttaaa agatttagcg gccgatttta ggtcaagaag tgagctgccc cagattaaca
     7741 gccaagaaga aaccaagatt tatggtcgct taggaccgtg tggcagacca ctgtgctgct
     7801 ttcgtttttg ggaaaatttc tgacaatatc tattaaaata ctaaaaaatc aaaggttatc
     7861 attgactttg ggtaaagcaa caagccctta tggccgtttg ctttgctgtc tctatgatga
     7921 aggtggcttt taccaataaa gcaagaaaaa attccctgaa tatggtacca tagtagagac
     7981 aagtgatggc cctgcaacag tagcagcctt gatatattta cagatcccat taaggtgcgg
     8041 ttaaaagacc agttgacctt agtcacttat gctttagagg aggttaaagt aggtgaataa
     8101 aaaagaatta ttcgatgctt ttgatggatt ttcccaaaat ttaatggtta ctttagctga
     8161 aattgaagcc atgaaaaaac aagtccaatc actagtagaa gaaaacacga ttcttcgcct
     8221 agaaaataca aaactacggg aacgtttgag tcacctagaa catgaaacgg tagctaaaaa
     8281 tccttccaaa caaaggaagg atcacttaga gggaatttat gatgaagggt ttcatatctg
     8341 caattttttc tatggacaac gtcgtgaaaa tgatgaagaa tgtatgtttt gcagagaatt
     8401 attagataga aagtaagggc atgcaggttc aaaaaagttt taaagacaaa aaaacaagcg
     8461 gaaccttgta tttggttcca accccaattg gcaatctgca ggacatgacc tttagagcag
     8521 tggcaacgtt aaaagaggtt gattttattt gtgcagaaga cacaagaaac acaggtcttt
     8581 tgctaaaaca ctttgacatt gctaccaagc aaatcagctt tcatgagcac aacgcctatg
     8641 agaagattcc tgatttaatt gatttattaa tatcaggacg gtcactagct caggtatctg
     8701 atgcaggaat gccatcgatt tctgatcctg ggcatgattt ggtcaaggct gctattgata
     8761 gtgatatcgc agtcgttgct ttaccaggtg cctcagcagg gattacagct ttgattgcta
     8821 gtggactggc tcctcaaccc catgtttttt atggattttt acccagaaaa gcagggcaac
     8881 aaaaggcttt ctttgaggac aaacaccatt acccagagac acaaatgttt tatgaatcgc
     8941 cctatcgcat caaagatacc ctgaccaata tgttggcttg ttatggtgat cgtcaagtgg
     9001 tacttgttag agaattaacc aagctttttg aggagtacca acgggggtcg attttagaaa
     9061 tcttgtccta ccttgaggaa acacccctaa aaggggagtg tctgctgatt gtggctggag
     9121 cccaagtaga cagtgaggtt gagctgacag ctgatgttga cttagtgtct ctagtgcaaa
     9181 aagaaatcca agcaggagcc aagccaaatc aggctattaa aacaattgct aaagcttacc
     9241 aggtaaatcg ccaagagctt taccaacaat ttcatgactt ataagtcatc gtagattagg
     9301 agaaaaacaa atgacagaag atcaagcaac tatccttatt ttaggagtat acggaatcat
     9361 attggctgta ttcttattat cagccttatt atgccttatc gctaactggc gactctttaa
     9421 aagagcaggt tacaaaggat ggtatagtct cattcctttc tatgcaggtt ttgtcaaaca
     9481 caaaatcact tttggagaag ataataaatg gttttacttt attggttggg tcattgctat
     9541 ttattattac tatgtgcact tttgctatgt ccgtgctttt ggtggatcaa agggtctagc
     9601 agtatttggc ttgtttttcc caggcattgc ttctttgata gtggcttttg gaaaaactta
     9661 taccacacaa gaatgccacc ctgtgccaca tcttttaaac taagagaaaa aagaccatca
     9721 attggattta ttgatggtct tttaggtgtt taaatgattt tagtcccgtg aacaatggcc
     9781 gttccagtga gttgactcaa gctttggcaa ttctcagcag tgacgcctcc tccaatcatg
     9841 atttcaatgc gtttattggc ataggtcaca agacttttaa gctgttccac attatctgta
     9901 ataggagtag cttcagggga gccatgagtt agcacacgca caaagccata atcaatcagt
     9961 tggtcaagcg cttggtgctg gtgatcagtc ggaatccggt caaaagccat gtggaaaacc
    10021 agtggcagtc cttgtgttgc aggcagtaat tgctcgatag cgtcggtatc cagttgattt
    10081 tctgtggtca gcaagcctaa gactagcgca tctgagccag cttcaacagc ttttaagata
    10141 tcttcttcca tagcttttag ttcgaggtcg ttatagacaa aatcaccacc gcgaggtcga
    10201 atcatggtcg ctacgctaat ctttttatcg tgtaagagct gacaggcttc tttgatgacg
    10261 ccataagatg gtgttgttcc cccgacagct aggttatcac agagttccac acgactgact
    10321 tgaccagcat caagggttgg cagtagtgtg aggttctcag cacaaaattc tttaatcatt
    10381 tttagatctc ctttatcact aatattatag cacgaatgaa gctagtcatc aggaaacatt
    10441 tttgtcaaat catggacatt atgctatact cactagtatt aaaagtaggc caaaacagca
    10501 gcaaatactt tgaaaaaaga ttgctatgtt ctacggcaat atcagtcttt accaacgaac
    10561 tctcaagaag aaaagaaaga caaagcttag cattttaaaa aagccccccc tttttttgtg
    10621 aaatgatgac caaaaacagg cgcctcacgc ctaaaacagt taccctaaag gagaacaaat
    10681 gattacgatt taccaatacc caaaatgtag cacctgccaa agagccatgg ctgaattaaa
    10741 gcaactggtt agtgactttg aagccattga catcaaagct aatccaccca aagctcagga
    10801 cctcaaacat tggatggaaa catctggtta taccatcaaa aatttcttta ataccagtgg
    10861 taacagctac cgcgaattgg gacttaaaga taaaatagac cagcttagcc ttgataaagc
    10921 tgctgaactc ttagccacag atggtatgct gattaaacgg cctattctga ttaaggacgg
    10981 taaagtccta caagttggct atcgcaagcc atatcaagag ttggatttag gataatgcga
    11041 caaagtctca aaaaaggaca aggcaacatt ataacgcctt gtcctttttt gggatctgtt
    11101 tttagacatt agagatcaat atctagtaaa attggcgtat ggtcttggcg ttccccagaa
    11161 gaaatcattt cagaacgctt aatcttatcc acgattcggt ttgaagctag ccaatagtca
    11221 attctccaac cggtattatt gattttgctg gttttactac gttgtgccca ccaggtataa
    11281 acatgaggaa tatcgccgtg caagtgacga aaagtatctg taaagcctct tgctaatagg
    11341 ttagtaaagc cttgacgttc ttcgtcggta aaaccagggg aacgtcgatt gctgcttgga
    11401 tttgccaaat caatctcttt gtgggcaacg ttgtaatctc ccgtagccaa aacaggcttt
    11461 tgagtatcca gttcagtcaa gtaatcagcg tatttgtggt cccagatttg acggtcatct
    11521 aaccgtctaa ggccatcacc agcattaggc gtgtaaacct gtgtgacgaa aaagtcttca
    11581 aattctaggg taatgatacg accctcagca tccattgttg ttggggcacc aatttctgga
    11641 aaagtaatga cagggtttag cgtgtttttg tacaggaaca tggtgccagc atagcctttc
    11701 ctagcaggct caactgaaga acgccacaca tgcaaatagt ttggaaagta actaagtagg
    11761 gtctcgatat gttttttggt aggcccctta gcagataatt tagtttcttg aatggcaata
    11821 atatccgcat cttgagcgac taaagtgtct aaaacagcgc gtgataaaag cgcacgaggg
    11881 gactctcctg tgagagcagc atttaaggaa tcaatgttcc atgaaatcag tttcatttgg
    11941 tatctctttc taacagatag tcttgttgtt attgtaacaa aaaacgaaac gataagcgac
    12001 tttgggcacc tagcccccat aaaacagtct agccaaatga agcatagcag cgtaagaaca
    12061 agacaaggag gtgatcagtg agcatatcgt ttgacagtta agagtaggat tactataata
    12121 gaagcataaa tgtaagcgct aacaaaataa aaaatatagg agaatgtcaa tggcacaaaa
    12181 aacagtcatc accgaagaaa caaccgattt tgttatggat ttcaaaacaa gtagcgctga
    12241 gggaaatgtt gattttatta acgtttttga ccttgagaaa atggcacaac aggtcatccc
    12301 taaaggagcc tttggttata ttgctagtgg tgctggtgat acctttaccc tccatgaaaa
    12361 tattcgctca tttaatcata aattaattgt ccctcactcc ctcaaagggg ttgaaaatcc
    12421 gtcaacagag attacgtttg atggcgatca cttaacctct cctcttattt tagcacctgt
    12481 agcggctcat aaactggcca atgaacaagg agaagtagcg tctgccaaag gattgaagga
    12541 atttggaagt atctacacca ctagttccta ctcaacaact gacctgccag aaatcagtgc
    12601 tgccttaggt gagacacccc attggtttca attttattac agtaaagacg atggcattaa
    12661 tcgtaatatt atggatcgtg tcaaagcaca aggttgcaaa gctatcgttt tgacagcaga
    12721 tgcaacagtt ggaggaaacc gcgaagttga taggcgaaac ggttttgttt ttccggtcgg
    12781 tatgccaatt gttcaagaat atttacctga tggtgcaggt aaaacaatgg attatgtcta
    12841 taaatcagct aaacaagcgc ttacctcaaa agatattgaa tatatcgcaa cctactcagg
    12901 cctgcctgtt tatgtcaaag gaccacagtg tgctgaggat accttgcggg cattggacgc
    12961 aggagcatca ggcatctggg taaccaatca tggtggccgt caattagatg gtggtccagc
    13021 tgcttttgat tccttacaag aagtcgctga agcagttgat caaaaagttc ctattgtctt
    13081 tgattcaggt ataagacggg gtcaacatat tttcaaagct cttgcttcag gtgctgacct
    13141 tgttgccttg gggcgtccag cgatttatgg cttggctatg ggaggaagca ttggtactcg
    13201 tcaggtcttt gaaaagttaa atgacgagtt aaaaatggtc atgcaactgg ctgggacaca
    13261 aactatccaa gatgttaaag cctttaacct tcgccacaat ccgtatgatt catcgattcc
    13321 atttgatcaa aatgcgctac gcttagatta gaacagacaa aaacctctgc tatcatgtca
    13381 caaatagtag aggttttaca ctgcaaaaag aggtgtgaaa attcaataac atagttacaa
    13441 ggctttcgtt taacaccccc cgataataga ttaaaatgaa agacttctta cattaataga
    13501 agtttctgtt gattttctca gaaaaatgtg gttaaataat caaatattat taacgaaaaa
    13561 tgagttaacg attaacatta aactggtttt agttaaaaca tttaggaggg tatcaggtgg
    13621 agaaaaagca acgtttttcc cttagaaaat acaaatcagg aacgttttcg gtcttaatag
    13681 gaagcgtttt cttgatgatg atgacgacaa caacagtagc agcagatgag ctaaccacaa
    13741 cgagtgaacc aacaatcacg aatcacgctc aacaacaagc gcaacatctc accaatacag
    13801 agttgagctc agctgaatca caatccccag acacatcaca aatcactccc aagacaaatc
    13861 gtgaaaaaga gcaaccacaa ggtctagtct ctgagccaac cacaactgag ctagctgaca
    13921 cagatgcagc atcaatggct aatacaggtc ctgatgcgac tcaaaaaagc gcttctttac
    13981 cgccagtcaa tacagatgtt cacgattggg taaaaaccaa aggagcttgg gacaagggat
    14041 acaaaggaca aggcaaggtt gtcgcagtta ttgacacagg gatcgatccg gcccatcaaa
    14101 gcatgcgcat cagtgatgta tcaactgcta aagtaaaatc aaaagaagac atgctagcac
    14161 gccaaaaagc cgccggtatt aattatggga gttggataaa tgataaagtt gtttttgcac
    14221 ataattatgt ggaaaatagc gataatatca aagaaaatca attcggggat tttgatgagg
    14281 actgggaaaa ctttgagttt gatgcagagc caaaagccat caaaaaaaac aagatctatc
    14341 gtccccaatc aacccaggca ccgaaagaaa ctgttatcaa aacagaagaa acagatggtt
    14401 cacatgatat tgactggaca caaacagacg atgacaccaa atacgagtca cacggtatgc
    14461 atgtgacagg tattgtagcc ggtaatagca aagaagccgc tgctactgga gaacgctttt
    14521 taggaattgc accagaggcc caagtcatgt tcatgcgtgt ttttgccaac gacgtcatgg
    14581 gatcagctga atcactcttt atcaaagcta tcgaagatgc cgtggcttta ggagcagatg
    14641 tgatcaacct gagtcttgga accgctaatg gggcacagct tagtggcagc aagcctctaa
    14701 tggaagcaat tgaaaaagct aaaaaagccg gtgtatcagt tgttgtagca gcaggaaatg
    14761 agcgcgtcta tggatctgac catgatgatc cattggcaac aaatccagac tatggtttgg
    14821 tcggttctcc ctcaacaggt cgaacaccaa catcagtggc agctataaac agtaagtggg
    14881 tgattcaacg tctaatgacg gccaaagaat tagaaaaccg tgccgattta aaccatggta
    14941 aagccatcta ttcagagtct gtcgacttta aaaacataaa agatagccta ggttatgata
    15001 aatcgcatca atttgcttat gtcaaagagt caactgatgc gggttataaa gcacaagacg
    15061 ttaaagataa aattgcttta attgaacgtg atcccaataa aacctatgac gaaatgattg
    15121 ctttggctaa gaaacatgga gccctgggag tacttatttt taataacaag cctggtcaat
    15181 caaaccgctc aatgcgtcta acagctaatg ggatggggat accatctgct ttcatatcgc
    15241 acgaatttgg taaggccatg tcccaattaa atggcaatgg tacaggaagt ttagagtttg
    15301 acagtgtggt ctcaaaagca ccgagtcaaa aaggcaatga aatgaatcat ttttcaaatt
    15361 ggggcctaac ttctgatggc tatttaaaac ctgacattac tgcaccaggt ggcgatatct
    15421 actctaccta taacgataac cactatggta gccaaacagg aacaagtatg gcctctcctc
    15481 agattgctgg cgccagcctt ttggtcaaac aatacctaga aaagactcag ccaaacttgc
    15541 caaaagaaaa aattgctgat atcgttaaga acctattgat gagcaatgct caaattcatg
    15601 ttaatccaga gacaaaaacg accacctcac cgcgtcagca aggggcagga ttacttaata
    15661 ttgacggagc tgtcactagc ggactttatg tgacaggaaa agacaactat ggcagtatat
    15721 cattaggcaa catcacagat acgatgacgt ttgatgtgac tgttcacaac ctaagcaata
    15781 aagacaaaac attacgttat gacacagaat tgctaacaga tcatgtagac ccacaaaagg
    15841 gccgcttcac tttgacttct cgctccttaa aaacgtacca aggaggagaa gttacagtcc
    15901 cagctaatgg aaaagtgact gtaagggtta ccatggatgt ctcacagttc acaaaagagc
    15961 taacaaaaca gatgccaaat ggttactatc tagaaggttt tgtccgcttt agagatagtc
    16021 aagatgacca actaaataga gtaaacattc cttttgttgg ttttaaagga caatttgaaa
    16081 acttagcagt tgcagaagag tccatttaca ggttaaaatc tcaaggcaaa accggttttt
    16141 actttgatga atcaggtcca aaagacgata tctatgtcgg taaacacttt acaggactcg
    16201 tcactcttgg ttcagagacc aatgtgtcaa ccaaaacgat ttctgacaac ggtctacaca
    16261 cacttggtac ctttaaaaat gcagatggca aatttatctt agaaaaaaat gcccaaggaa
    16321 accctgtctt agccatttct ccaaatggtg ataacaacca agattttgca gccttcaaag
    16381 gtgttttctt gagaaaatat caaggcttaa aagcaagtgt ctaccatgct agtgacaagg
    16441 aacacaaaaa tccactatgg gtcagcccag aaagctttaa aggagataaa aactttaata
    16501 gtgacattag atttgcaaaa tcaacgaccc tgttaggcac agcgttttct ggaaaatcgt
    16561 taacaggagc tgaattacca gatggatatt atcattatgt ggtgtcttat tacccagatg
    16621 tggtcggtgc caaacgtcaa gaaatgacat ttgacatgat tttagaccga caaaaaccgg
    16681 tactatcaca agcaacattt gatcctgaaa caaaccgatt caaaccagaa cccctaaaag
    16741 accgtggatt agctggtgtt cgcaaagaca gtgtctttta tctagaaaga aaagacaaca
    16801 agccttatac agttacgata aacgatagct acaaatatgt ctcagtagaa gacaataaaa
    16861 catttgtgga gcgacaagct gatggcagct ttatcttgcc gcttgataaa gcaaaattag
    16921 gggatttcta ttacatggtc gaggattttg cagggaacgt ggccatcgct aagttaggag
    16981 atcacttacc acaaacatta ggtaaaacac caattaaact taagcttaca gacggtaatt
    17041 atcagaccaa agaaacgctt aaagataatc ttgaaatgac acagtctgac acaggtctag
    17101 tcacaaatca agcccagcta gcagtggtgc accgcaatca gccgcaaagc cagctaacaa
    17161 agatgaatca ggatttcttt atctcaccaa acgaagatgg gaataaagac ttcgtggcct
    17221 ttaaaggctt gaaaaataac gtgtataatg acttaacggt taacgtatac gctaaagatg
    17281 accaccaaaa acaaacccct atctggtcta gtcaagcagg cgctagtgca tccgctattg
    17341 aaagtacagc ctggtatggc ataacagccc gaggaagcaa ggtgatgcca ggtgattatc
    17401 agtatgttgt gacctatcgt gacgaacatg gtaaagaaca tcaaaagcag tacaccatat
    17461 ctgtgaatga caaaaaacca atgatcactc agggacgttt tgataccatt aatggcgttg
    17521 accactttac tcctgacaag acaaaagccc ttggctcatc aggcattgtc cgcgaagaag
    17581 tcttttactt ggccaagaaa aatggccgta aatttgatgt gacagaaggt aaagatggta
    17641 tcacagttag tgacaataag gtgtatatcc ctaaaaatcc agatggttct tacaccattt
    17701 caaaaagaga tggtgtcaca ctgtcagatt attactacct tgtcgaagat agagctggta
    17761 atgtgtcttt tgctaccttg cgtgacctaa aagcggtcgg aaaagacaaa gcagtagtca
    17821 actttggatt agacttaccg gtccctgaag acaaacaaat agtgaacttt acttaccttg
    17881 tgcgggatgc agatggtaaa ccgattgaaa acctagagta ttataataac tcaggtaaca
    17941 gtcttatctt gccatacggc aaatacacgg tcgaattgtt gacctatgac accaatgcag
    18001 ccaaactaga gtcagataaa atcgtttcct ttaccttatc agctgataat aacttccaac
    18061 aagttacctt taagatgacg atgttagcaa cctctcaaat aactgcccac tttgatcatc
    18121 ttttgccaga aggcagtcgc gttagcctta aaacagctca aggtcagctg atcccgcttg
    18181 aacagtcctt gtatgtgcct aaagcttatg gcaaaactgt tcaagaagac acttacgaag
    18241 ttgttgtcag cctgcctaaa ggctaccgta tcgaaggcaa cacaaaggtg aatgccctac
    18301 caaatgaagt gcacgaacta tcattacgcc ttgtcaaagt aggagatgcc tcagattcaa
    18361 ctggcgatca taaggttatg tcaaaaaata attcacaggc tttgacagtc tctgccacac
    18421 caaccaagac aacgacctca gcaacagcaa aagccctacc atcagcgggt gaaaaaatgg
    18481 gtctcaagtt gcgcatagta ggtcttgtgt tactcggact tacttgcgtc tttagccgaa
    18541 aaaaatcaac caaagattga taacaaaacg caaagagaca acaaatcatc ccttttaaca
    18601 gtcggacctt tctttgaaat tgagctggca gatgatcatt tcttaacaaa agttaaagag
    18661 ttgagcaaag taaggaacag acataaagat cataaaagca agccagtttg gcttgctttt
    18721 atggtgttat tgtcgtgtgc tacgatgact aaaaaagaac aacgaacaat gacctcgaat
    18781 caccaaaagg acttgatttg atagcttccc tatgctatac taagcctatt ctttcaagaa
    18841 ggactccttt tgtggaaaag actgaaaaaa aggacactaa tctatccaaa aactccagat
    18901 gagtagctgc aaccggatgc ctctgctgtg atcaaggtga taaagcagac tggcttgtca
    18961 ctacctgagc aggtgtcaaa aaaagaagct ttggctttgt cattcaacat actgagcttt
    19021 agtctttcag aacggagaca cccccagttt tgtactcaaa aagcataaac agctctgctg
    19081 atgcgacatc cgatttctac gtccgcagtg agccaaacca gctgctgttt gctatggtaa
    19141 aagtggcgcc aatcgggatt tttgagatcc taggctcaaa aataaggcat agaattccaa
    19201 aggaagtcgc tgccgtgagc acaacctaag aaaaactatc ccaaaagact ttttctgcaa
    19261 tttgaaatac tgaatttcag tattttttct tttgtaacta agagcaatga atgaggtaaa
    19321 aaaaggcaac aatgtcaaaa aagaaacgaa aacactatca ggtttatgag ggattacgct
    19381 gtgctatgac gctttgtttt atcagtggct atgtcaatgc ctttacctat atgacccaag
    19441 gaaaacgttt tgcaggtgtt cagacaggca accttttgtc atttgccatt cgcttgtcag
    19501 aacagcaact gaaggaggca ctgcaatttt tacttcccat gatagttttt atgcttgggc
    19561 agtcctttac ttatttcatg caccgctggg ccactaaaaa aaggctccac tggtacctct
    19621 tatcaagcgt tatgttaaca ggacttgctt ttggaacagc cctattcacg ccttttcttc
    19681 cttccaatgt tacggtagca gctttagcct tttttgcctc tattcaggtt gatacgttta
    19741 aaaccttacg aggagctagc tatgctaatg tgatgatgac aggaaatatc aaaaatgccg
    19801 cctatttact aaccaaaggc ttgtacgaaa aaaatcacga actaacacat atcggacgca
    19861 acaccttaat agtcatcttg gcttttgctg ttggggtggt ttgttcgacg ttgctttgca
    19921 tagcttatgg tgagtatgct ttgatgccta ttttaatgcc tttactctat gtcaattacc
    19981 tgttggctca ggaattttat cacattcaaa ccaaaatcaa accgattaaa agaacttaac
    20041 ggacttgtgg agaaagaaag ttcatttagg gtaagttttt actcaccctc cttt
//
LOCUS       DAUDWO010000036        20016 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.036, whole genome shotgun sequence.
ACCESSION   DAUDWO010000036 DAUDWO010000000
VERSION     DAUDWO010000036.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20016)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20016)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20016
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.036"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            58..1026
                     /locus_tag="VHC05_001345"
     CDS             58..1026
                     /locus_tag="VHC05_001345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /protein_id="HEQ5402646.1"
                     /translation="MVTVSKEQHLDMFLKMERIREFDSRINKLVRRGFVQGMTHFSVG
                     EEAANVGAVAHLSYDDIIFSNHRGHGQSIAKDMDLNKMMAELAGKATGVSKGRGGSMH
                     LADFEKGNYGTNGIVGGGYALAVGAALTQQYKGTNNIAVAFSGDGATNEGSFHESVNM
                     AATWKLPVIFFIINNRYGISMSINNATNTPHLYTRAEAYGIPGFYCEDGNDVMAVYET
                     MGKAVEHVRGGNGPAIVEVESYRWFGHSTADAGKYRTKEEVDEWKEKDPMIKYRTYLT
                     SEGIATDDELDAIQAQVKKEVDDAYEFAQNSPDPELSVAFEDVWVD"
     gene            1085..2083
                     /locus_tag="VHC05_001346"
     CDS             1085..2083
                     /locus_tag="VHC05_001346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="HEQ5402647.1"
                     /translation="MSETKLMALREAVNLAMTEEMRKDENIFLMGEDVGVYGGDFGTS
                     VGMIEEFGPKRVKDTPISEAAISGAAIGAAITGLRPIVDVTFMDFLTIMMDAIVNNGA
                     KNNYMFGGGLITPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGIKVVAPGNANDAKGL
                     LKSAIRDNNIVLFMEPKALYGKKEEVNQDPDFYIPLGKGDIKREGTDLTIVSYGRMLE
                     RVLQAAEEVAADGINVEVVDPRTLIPLDKELIIESVKKTGKLMLVNDAYKTGGFIGEI
                     ATMITESEAFDYLDHPIVRLASEDVPVPYARVLEQAILPDVEKIKAAIVKMANKGN"
     gene            2268..3677
                     /locus_tag="VHC05_001347"
     CDS             2268..3677
                     /locus_tag="VHC05_001347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoamide acetyltransferase"
                     /protein_id="HEQ5402648.1"
                     /translation="MAFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKT
                     NMELEAEDSGVLLKIVRPAGDTVPVTEVIGYIGAEGESVDTIASSEKTTEIPVPASAD
                     AGPTVAPKENVASPAPQVAATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKG
                     RVHKEDVENFKGAQPKASPLARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKP
                     AEAKAPAAKEEKVVDLPEGVEHKPMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMI
                     ALRKKLIDPIMAKTGLKVSFTDLIGMAVVKTLMKPEHEYMNASLINDANDIELHRFVN
                     LGIAVGLDDGLIVPVIHGADKMSLSDFVLASKDVIKKAQTGKLKAAEMSGSTFSITNL
                     GMFGTKTFNPIINQPNSAILGVGATIPTPTVVDGEIVARPIMAMCLTIDHRLVDGMNG
                     AKFMVDLKKLMENPFELLI"
     gene            4008..5771
                     /gene="lpdA"
                     /locus_tag="VHC05_001348"
     CDS             4008..5771
                     /gene="lpdA"
                     /locus_tag="VHC05_001348"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HEQ5402649.1"
                     /translation="MAVEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKT
                     NMELEAEDSGVLLKITRQAGETVPVTEVIGYIGAEGESVEVSSPAASDVNVARTTEDL
                     EAAGLEVPKAPAQAASAAPKAALADDEYDIIVVGGGPAGYYAAIRGAQLGGKIAIVEK
                     SEFGGTCLNVGCIPTKTYLKNAEILDGIKIAAGRGINLASTNYTIDMDKTVDFKNTVV
                     KTLTGGVQGLLKANKVTIFNGLGQVNPDKTVTIGSQTIKGRNVILATGSKVSRINIPG
                     IDSKLVLTSDDILDLREMPKSLAVMGGGVVGIELGLVWASYGVDVTVIEMADRIIPAM
                     DKEVSLELQKILSKKGMKIKTSVGVSEIVEANNQLTLKLNNGEEVVAEKALLSIGRVP
                     QMNGLENLNLEMDRNRIKVNDYQETSIPGIYAPGDVNGTKMLAHAAYRMGEVAAENAI
                     HGNTTRKANLKYTPAAVYTHPEVAMVGLTEEQAREQYGDVLIGKNSFTGNGRAIASNE
                     AHGFVKVIADAKYHEILGVHIIGPAAAEMINEAATIMESELTVDELLLSIHGHPTFSE
                     VMYEAFADVLGEAIHNPPKRK"
     gene            complement(6258..8864)
                     /gene="hylA"
                     /locus_tag="VHC05_001349"
     CDS             complement(6258..8864)
                     /gene="hylA"
                     /locus_tag="VHC05_001349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hyaluronidase"
                     /protein_id="HEQ5402650.1"
                     /translation="MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNN
                     TYFQTQTLTTTDSEKKVVQPQQKDYYTELLDQWNSIIAGNDAYDKTNPDMVTFHNKAE
                     KDAQNIIKSYQEPDHENRTYLWEHAKDYSASANITKTYRNIEKIAKQITNPESCYYQD
                     SKAIAIVKDGMAFMYEHAYNLDRENHQTTGKENKENWWDYEIGTPRAINNTLSLMYPY
                     FTQEEILKYTAPIEKFVPDPTRFRVRAANFPPFEANSGNLIDMGRVKLISGILRKDDL
                     EISDTIKAIEKVFTLVDEGNGFYQDGSLIDHVVTNAQSPLYKKGIAYTGAYGNVLIDG
                     LSQLIPIIQKTKSPIEADKMATIYHWINHSFFPIIVRGEMMDMTRGRSISRFNAQSHV
                     AGIEALRAILRIADMSEEPHRLALKTRIKTLVTQGNVFYNVYDNLKTYHDIKLMKELL
                     SDTSVPVQKLDSYVASFNSMDKLALYNNKHDFAFGLSMFSNRTQNYEAMNNENLHGWF
                     TSDGMFYLYNNDLGHYSENYWATVNPYRLPGTTETEQKPLEGTPENIKTNYQQVGMTS
                     LSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNKGWFILGNKIIFVGSNIKNQSSHKA
                     YTTIEQRKENQKHPYCSYVNNQPVDLNNQLVDFTNTKSIFLESDDPAQNIGYYFFKPT
                     TLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQNHTQDGDRYAYMMLPNMTRQ
                     EFETYISKLDIDLLENNDKLAAVYDHDSQQMHVIHYEKKATTFSNHNLSHQGFYSFPH
                     PVKQNQQQKLAHQGIAAKNNALNSHKIPHKRQRRLPRTGYQSSSLEFLGGALVASFNH
                     ITKPFRKKDLRI"
     gene            9097..10086
                     /locus_tag="VHC05_001350"
     CDS             9097..10086
                     /locus_tag="VHC05_001350"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007893175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HEQ5402651.1"
                     /translation="MKYIVNKSHNPAFNIALEAYAFRELVEEDELFILWINEPAIIIG
                     KHQNTIQEINKEYIDEHGIHVVRRLSGGGAVYHDLNNLNYTIISNKTAEGAFDFKTFS
                     QPVIATLADLGVTANFTGRNDIEIDGKKICGNAQAYYKGRMMHHGCLLFDVDMTVLGD
                     ALKVSKDKIESKGVKSVRARVTNILNELPEKITVEEFSDKILTKMKETYPDMTEYVLS
                     EDELAKIEQSAKEQFGSWDWTYGKAPEYTIERNVRYPAGKISTFANVENSIIKNLKIY
                     GDFFGIKDVQDIENLLIGCKYEYRDVFERLKTIDTTQYFSRMTVEEVAKAIVS"
     gene            complement(10195..10986)
                     /locus_tag="VHC05_001351"
     CDS             complement(10195..10986)
                     /locus_tag="VHC05_001351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glutamine amidotransferase"
                     /protein_id="HEQ5402652.1"
                     /translation="MTYTSLKSPENQDYIYDLNIAHLYGNLMNTYGDNGNILMLKYVA
                     EKLGARVTVDIVSINDTFEQDDYDIVFFGGGQDYEQSIVAKDLPSKKAALADYIANNK
                     VVLAICGGFQLLGQYYVQANGVKIDGLGIMGHYTLNQHQNRFIGDIKIHNDEFNETYY
                     GFENHQGRTFLSGDEKPLGRVVYGNGNNKEDQTEGVHYKNVYGSYFHGPILSRNVNLA
                     YRLVTTALKKKYGSAISLPSYDDILKQEITEEYADLKSKASFNKV"
     gene            complement(10986..12329)
                     /locus_tag="VHC05_001352"
     CDS             complement(10986..12329)
                     /locus_tag="VHC05_001352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mur ligase family protein"
                     /protein_id="HEQ5402653.1"
                     /translation="MKMKTLLGIIAGKAAQSILTKLGRGSTYPGRLALACNKDILKDL
                     SKDYDIVVVTGTNGKTLTTALTVGILKEAFGEIITNPSGANMITGITSTFLAAKKGKS
                     GKQIAVLEIDEASLPKITTYLKPSLFVYTNIFRDQMDRYGEIYTTYQMIVDGARNAPK
                     ATILANGDSPIFSSKDIVNPVQYYGFDTAKHAPQLAHYNTEGILCPKCEHILQYRLNT
                     YANLGDFICLNCGFKRPQLDYRLTELTTITNHSSEFIIDGQDYKINVGGLYNIYNALA
                     AVSVAEFFGVSPEKIKAGFNKSKAVFGRQETFTIGDKSCTLILIKNPVGASQALEMIQ
                     LADYPFSLSVLLNANYADGIDTSWIWDANFELITQMPITEINAGGVRHSEIARRLRVT
                     GFDDTKIKQAEKLEQIIETIEKQEAKHAYILATYTAMLEFRSLLADRHVVEKEMI"
     gene            12436..13287
                     /locus_tag="VHC05_001353"
     CDS             12436..13287
                     /locus_tag="VHC05_001353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00159 family protein"
                     /protein_id="HEQ5402654.1"
                     /translation="MNNLSSIDIKFLLSLFADPWLLAVHLLDILIVAYLIYRFIKALT
                     GTKIMSLVQGVIFFLVLRFIAEWIGFTTITYLMNQVITYGVIAGVVIFTPEIRAGLEK
                     FGRSTQVFLQKQYVSSESALVDALIKSVAYMGPRKIGALIAIEQTQTLQEYIATGIPL
                     NADISSQLLINIFIPNTPLHDGAVIVGQNKIVAACAYLPLSESKAISKEFGTRHRAAI
                     GLSENSDALTIIVSEETGAISVTRKGQFLHDLSTDEFETVLRTYLMSDSNVSLPWYKK
                     ILGGKSK"
     gene            13284..14240
                     /locus_tag="VHC05_001354"
     CDS             13284..14240
                     /locus_tag="VHC05_001354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbbR-like domain-containing protein"
                     /protein_id="HEQ5402655.1"
                     /translation="MKRFLNSRPWLGMVSVFFAILLFLTAASSNHNNSSSQIYSPIET
                     YTHSLKDVPIDMKYDSDKYFISGYSYGAEVYLTSTNRIKLDSEVNNDTRNFKIVADLT
                     HSHPGTVSVNLRVENLPSGVTATVSPDKISVTIGKKESKVFPVRGSVDAKQIANGYEI
                     SKIETGVNKVEVTSDESTIALIDHVVAKLPDDQVLDRNYSSRVTLQAVSADGTILASA
                     IDPAKTNLSVAVKKITKSVPIRVEAVGMMDDSLSDIQYKLSKQTAVISGSREVLEDID
                     EIIAEVNISDVTKNTSKTVSLSSSQVSIEPSVVTVQLTTTKK"
     gene            14294..15649
                     /locus_tag="VHC05_001355"
     CDS             14294..15649
                     /locus_tag="VHC05_001355"
                     /EC_number="5.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglucosamine mutase"
                     /protein_id="HEQ5402656.1"
                     /translation="MGKYFGTDGVRGEANVELTPELAFKLGRFGGYVLSQHETERPKV
                     FVARDTRISGEMLESALIAGLLSVGIEVYKLGVLATPGVSYLVRTEKASAGVMISASH
                     NPALDNGIKFFGNDGFKLADDQELEIEALLDAPEDTLPRPSAEGLGTLVDYPEGLRKY
                     EKFLVTTGTDLSGMTVALDTANGAASVSARDVFLDLNAEIAVIGEKPNGLNINDGVGS
                     THPEQLQELVKETGADLGLAFDGDSDRLIAVDETGEIVDGDRIMFIIGKYLSEKGLLA
                     HNTIVTTVMSNLGFHKALDKQGINKAITAVGDRYVVEEMRSSGYNLGGEQSGHVIIMD
                     YNTTGDGQLTAIQLAKVMKETGKSLSELAAEVTIYPQKLVNIRVENSMKDRAMEVPAI
                     ANIIAKMEDEMAGNGRILVRPSGTEPLLRVMAEAPTDAEVDYYVDTIADVVRTEIGCD
                     N"
     gene            15773..16414
                     /locus_tag="VHC05_001356"
     CDS             15773..16414
                     /locus_tag="VHC05_001356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402657.1"
                     /translation="MTKQQIEKLADLLPPFAATLYLDMIPEFQEGYASYVYQTQKEDT
                     QNRRIKQLTKNFERLLDTPSFYVMPVTRKTAEQLLADKGLAYHLLSTVAANQVFAAAV
                     NEDQTLFQVLRNGARVAFVILQEKGEFLEMTLGILETVTENEVPAAIVEAVQTYLLAD
                     MQEKLPSLSIMVSQESSKLFYKEQGFVLLAKGCKPGNENDSDVCQLVKYFSKP"
     gene            16477..17607
                     /locus_tag="VHC05_001357"
     CDS             16477..17607
                     /locus_tag="VHC05_001357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxygen-independent coproporphyrinogen III
                     oxidase"
                     /protein_id="HEQ5402658.1"
                     /translation="MSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLRALIQE
                     FDSYGIRDLKTLYIGGGTPTAITAKQLEYLLNHLERNLNLDDLEEFTIEANPGDLTPE
                     KIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQIYSTIANLKAAGFHNISIDLIY
                     ALPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEM
                     FEYIISEMEANGFEHYEISNFTKPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQN
                     RVPIQHYLKAVEAGNARLNEEVLRKEEMMEEELFLGLRKKTGVSIQRFQEKFGMPFEE
                     RYGNIVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD"
     gene            17617..18369
                     /locus_tag="VHC05_001358"
     CDS             17617..18369
                     /locus_tag="VHC05_001358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-[acyl-carrier-protein] thioesterase"
                     /protein_id="HEQ5402659.1"
                     /translation="MGLSYQEELTLPFELCDVKSDIKLPLLLDYCLMVSGRQSAQLGR
                     SNNNLLVDYKLVWIVTDYEITIHRLPHFQETITIETKALSYNKFFCYRQFYIYDQEGC
                     LLVDILAYFALLNPDTRKVATIPEDLVAPFKTDFVKKLHRAPKMPLLEQSIDRDYYVR
                     YFDIDMNGHVNNSKYLDWMYDVLGCEFLKTHQPLKMTLKYVKEVSPGGQITSSYHLDQ
                     LTSYHQITSDGQLNAQAMIEWRAIKQTESETD"
     gene            18369..19133
                     /locus_tag="VHC05_001359"
     CDS             18369..19133
                     /locus_tag="VHC05_001359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003054515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01457 family HAD-type hydrolase"
                     /protein_id="HEQ5402660.1"
                     /translation="MPYKGYLIDLDGTIYQGKNRIPAGERFIKRLQEKGIPYLLVTNN
                     TTRTPEMVQSMLANQFHVETGIETIYTATMATVDYMNDMNRGKTAYVIGETGLKSAIA
                     AAGYVEELENPAYVVVGLDSQVTYEMLAIATLAIQKGALFIGTNPDLNIPTERGLMPG
                     AGALNALLEAATRVKPVFIGKPNAIIMNKSLEVLGIQRSEAVMVGDNYLTDIMAGIQN
                     DIATILVTTGFTRPEEVPTLPIQPDHVLSSLDEWRL"
     gene            19133..19765
                     /locus_tag="VHC05_001360"
     CDS             19133..19765
                     /locus_tag="VHC05_001360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01906 family membrane protein"
                     /protein_id="HEQ5402661.1"
                     /translation="MVENTKLLCSWVWLLALAILITIYSTWLWYPLEVDHLKLEQVVF
                     MSKDAILHNYNGLLNYLTNPFVTRLEFANFHSSADGLKHFADVKWLFHLTQVVFLGLL
                     YPTLKTFTQRLKTKRFWLLQKPLILAALFPLMIGLMASFIGFEHFFTLFHQVLFVGDS
                     SWLFDPLKDPVIWILPEVFFLHCFLFFMIVYEIILWSLVGLARWQRLNVE"
BASE COUNT         6189 a         3565 c         4178 g         6084 t
ORIGIN      
        1 caaattgtga aaaaaagttt tatcataaaa aggtaatatg ataatatgga ggccgaaatg
       61 gtaacagttt ctaaagaaca acatttggat atgttcctta aaatggaacg tattcgtgaa
      121 tttgattcac gtattaataa actcgtccgt cgtggatttg tacaagggat gactcacttc
      181 tcagttggtg aagaagcagc caatgttgga gcggtggctc acttgtctta cgatgacatt
      241 attttttcaa atcaccgtgg acatggacaa tcaatcgcta aagacatgga ccttaataaa
      301 atgatggctg agcttgctgg taaagcaact ggtgtttcta aagggcgtgg tggctcaatg
      361 cacttggctg attttgaaaa aggaaactat ggtaccaatg gtatcgttgg tggtggttac
      421 gctcttgcag ttggtgctgc cctcacccaa caatacaaag gaactaacaa tatagctgtt
      481 gctttctcag gtgatggcgc tactaacgaa ggatcattcc acgagtctgt taatatggct
      541 gcaacatgga aacttcctgt tattttcttc atcatcaaca accgttatgg aatttcaatg
      601 agcatcaata atgcaacaaa tacaccacac ttatacacac gtgcagaagc ttacggaatt
      661 cctggtttct actgtgaaga tggcaatgac gtgatggctg tctatgaaac aatgggcaaa
      721 gctgttgagc atgttcgtgg tggaaatggc ccagctattg ttgaggtaga atcataccgt
      781 tggtttggtc actcgactgc agatgctggt aaataccgta ctaaagaaga agtagatgag
      841 tggaaagaaa aagatccaat gatcaaatat cgtacttatc tgacaagcga aggcattgcc
      901 actgatgacg aattggatgc tattcaagca caagtcaaaa aagaagttga cgatgcttat
      961 gaatttgcac aaaacagtcc agatccagaa ctttcagtag ccttcgagga cgtttgggtt
     1021 gactaagatc accttgtcag taagaagcaa tcgtatttga ataataaatg gagaagtaaa
     1081 aatgatgtca gaaacaaaat taatggcttt gcgtgaagca gtcaaccttg ctatgactga
     1141 ggaaatgcgc aaggacgaaa acattttcct tatgggagaa gacgtagggg tttacggagg
     1201 agacttcggg acttctgttg gaatgattga agaatttggt cctaaacgtg ttaaagatac
     1261 cccaatttca gaagctgcta tctctggtgc agctattggt gcagcgatta caggactacg
     1321 tccaattgtc gacgttacct tcatggattt ccttactatc atgatggacg ctatcgtgaa
     1381 taatggtgct aaaaataatt acatgttcgg tggaggcctt attacccctg taaccttccg
     1441 tgtggcatca ggttctggta ttggttccgc tgcgcaacac tcacaatctc ttgaagcatg
     1501 gttgactcac attccaggaa tcaaagttgt tgctcctggt aatgccaacg atgctaaagg
     1561 cttattaaaa tcagctatcc gtgataataa cattgttctt ttcatggaac caaaagcgct
     1621 ttatggtaaa aaagaagaag ttaaccaaga tcctgacttc tatatcccac ttggcaaagg
     1681 tgacatcaaa cgtgaaggaa ctgatttgac aattgtgtca tacggtcgta tgttggagcg
     1741 tgttcttcaa gcggctgaag aagttgcagc ggatggtatt aacgttgaag ttgttgaccc
     1801 acgtaccctc atcccacttg ataaagagtt gattattgaa tctgttaaga aaacaggtaa
     1861 attgatgctt gtcaatgatg cttacaaaac aggtggattc attggggaaa ttgcaaccat
     1921 gattaccgaa agtgaagcct ttgattacct tgatcatcca atcgttcgtc ttgcaagtga
     1981 agatgttcca gtaccttatg cacgtgtact tgaacaagcg atcttaccag acgttgagaa
     2041 aataaaagct gctattgtga aaatggcaaa caaaggcaac tagaagataa ggcaagtggt
     2101 ctgataaagg ctatgtttat cagtaacgtc tcagctaaaa actattttga aagtttttag
     2161 aagaactgag ttgtcttatc ccgtgtcgcg gcacctcacc tttcgtatgt tttcgtagca
     2221 aggtggggat gttgatggcg cttatcaaat cgtgaaagga tgtagaaatg gcatttgaaa
     2281 ttattatgcc aaagctgggc gttgacatgc aagaaggcga gatcatcgag tggaaaaaac
     2341 aagaaggtga taccgtcaat gaaggtgata tccttcttga aatcatgtca gacaaaacca
     2401 atatggaact tgaggcagaa gactcaggtg tgctattgaa aattgtccgt ccagctggtg
     2461 atactgtacc tgtaactgaa gttatcggtt acattggtgc agagggtgaa tcagtagata
     2521 ctattgcttc aagtgaaaaa acaacagaaa ttccagttcc tgcttcagca gatgctggac
     2581 caacagttgc tccaaaagaa aatgtggcaa gtccagctcc tcaagtggca gcgacagcta
     2641 ttccgcaagg aaatggcgga aaagttcgtg ctactccagc tgcacgtaag gcagcagcag
     2701 aaatgggcat tgaccttggc caagttccag gaacaggacc aaaaggacgt gtccataaag
     2761 aagacgttga aaactttaaa ggtgctcaac cgaaagcttc accacttgct cgtaaaattg
     2821 cagcagacaa aggtattgat ttggcaaccg tatcaggtac tggctttaac ggtaaggtca
     2881 tgaaagaaga catcatggct attcttgaag cggctaaacc agctgaagca aaagccccag
     2941 cagctaaaga agaaaaagtt gttgatcttc cagaaggtgt ggaacacaag ccaatgtcag
     3001 ctatgcgtaa ggcaatctct aaaggtatga caaactctta ccttactgcc cctaccttta
     3061 cgcttaacta cgatattgac atgacagaga tgattgccct tcgtaagaag ttaattgacc
     3121 caatcatggc taaaacaggc cttaaagtca gcttcacaga cttgattggt atggcagtgg
     3181 ttaaaacctt gatgaaacct gagcatgagt acatgaatgc ttccctcatc aatgatgcta
     3241 atgatattga attgcaccgc tttgtgaacc ttggtattgc cgtaggtctt gatgatgggc
     3301 ttatcgttcc tgttatccat ggggctgaca agatgagctt gtcagatttt gtgcttgctt
     3361 caaaagatgt gattaaaaaa gcgcaaactg gtaagttgaa agcagctgaa atgtctggat
     3421 caaccttctc tatcacaaac ttgggaatgt ttggtacgaa gacatttaac ccaattatta
     3481 accaaccaaa ctcagcaatt cttggtgttg gagcaactat cccaactcca acggttgtgg
     3541 atggtgagat tgttgcccgt ccaattatgg caatgtgcct aaccatcgac caccgtttag
     3601 ttgatggtat gaacggtgca aaattcatgg ttgatctcaa gaaattgatg gaaaatccat
     3661 ttgaattgtt aatctgatca atcagtttta aacaagaaaa gcattcaata ataaaaggga
     3721 ttttgctaag tttagacttg gtgggtgccc ttttctcaaa aatatagaaa ggatgtagaa
     3781 cgaggagatc tcatgcaaat gagtgataag caattgaacc cgagcgaaaa gctcggataa
     3841 aaatggtaag agttggctaa tcttagcatc gtagacgtct gaactttcct caatttttgt
     3901 ttcggaaagt cctagtcgtc ctgacgtggg tgcgtcaacg aaatcaaaga tttctgactt
     3961 accgcaaaaa ttcaatcgct ttctccttgc tcttggtatc ttaaattatg gctgttgaaa
     4021 ttattatgcc aaaactcggt gttgacatgc aagaaggtga aatcatcgag tggaaaaaac
     4081 aagaaggtga tactgtcaat gaaggcgata ttcttcttga aatcatgtca gataaaacca
     4141 atatggaact tgaagcagaa gactcaggtg ttcttcttaa aattacacgt caagctggtg
     4201 aaacagtacc tgtaacagaa gttatcggct acatcggtgc tgaaggtgaa tctgttgagg
     4261 tttctagccc agctgcttca gatgtgaatg ttgctcgtac aacagaagat ttagaagctg
     4321 ctggacttga agtgccaaaa gcaccagctc aagctgcttc agctgcacca aaagctgcac
     4381 ttgctgatga tgagtatgac atcatcgttg ttggtggtgg ccctgctggt tattatgcag
     4441 ctattcgtgg tgctcaactt ggtggtaaaa ttgccatcgt tgagaaatct gaatttggtg
     4501 gaacttgctt gaacgtaggg tgtatcccaa ccaaaactta ccttaaaaat gctgaaatcc
     4561 ttgatggtat taagattgca gcaggacgtg ggattaacct tgcctcaact aactatacca
     4621 ttgacatgga caaaacagtt gactttaaaa acaccgttgt taaaacctta acaggcggcg
     4681 ttcaaggtct tctaaaagct aataaagtca ctatctttaa tgggcttggt caagtcaacc
     4741 ctgacaagac tgtaaccatt gggtcacaaa ccattaaggg tcgcaacgtt atccttgcta
     4801 caggttctaa agtatcacgt atcaatatcc caggtattga ctctaaactt gtcttaacgt
     4861 cagatgatat ccttgacctc cgtgaaatgc caaaatcact agcagttatg ggcggtggtg
     4921 ttgttggtat cgagcttgga cttgtttggg catcttacgg tgtggatgtt accgttattg
     4981 aaatggctga ccgtattatc ccagctatgg ataaagaagt ctctcttgaa cttcaaaaaa
     5041 tcctttctaa gaaaggcatg aagatcaaaa catctgttgg tgtctctgaa attgttgaag
     5101 caaataacca attgaccttg aaacttaaca atggtgaaga agttgtcgct gaaaaagctc
     5161 ttctttctat cggtcgtgta ccacaaatga acggtctgga aaatcttaac cttgaaatgg
     5221 atcgtaaccg tatcaaagtt aatgactacc aagagacatc aattccaggt atctatgcgc
     5281 caggtgacgt taacggaacg aaaatgcttg ctcacgctgc ttaccgtatg ggtgaagtgg
     5341 ctgcagaaaa tgcgatacat ggcaacacaa ctcgtaaagc taaccttaaa tacactccag
     5401 cagccgttta cacacaccct gaagtggcaa tggttggttt aactgaagaa caagcgcgtg
     5461 aacaatatgg tgatgtgctt attggtaaaa acagctttac tggtaatgga cgcgcgattg
     5521 cttcaaatga agcacatggt tttgttaaag ttattgctga tgccaaatac cacgaaatct
     5581 taggtgttca tattattggt ccagctgcag ctgagatgat taacgaagca gctactatta
     5641 tggaatctga attaaccgtt gatgaattgt tattatcaat tcatggacac ccaaccttct
     5701 ctgaagtgat gtacgaagcc tttgcagatg tgcttggcga agctatccat aacccaccaa
     5761 aacgtaagta aaacgtcttt gtcttattaa ctaatgaaaa atatcatcac ataacagatc
     5821 acaaaaaaga ctagcacaac tatgaactgc accccaaacg ttagatataa aaccctaacg
     5881 tttggggtgt ttttgtatga cattaagcta tgaagataag ctagacattt agcgctaaaa
     5941 aaaccgagag aactccgttt gaaagaagca tctctgaaaa gaagaagaca aaaaaccatt
     6001 ataaagaatg gacaaagacg agttctgatt agattttctt ttaaggacgg ctaaattgac
     6061 tcgttctacc tactattatc atcgattatt gcaacaataa acgtatcaaa ataaaacgaa
     6121 aaggacttag tcctctacaa tgcagaacta aatcctttac ttcaaataga gtagccaact
     6181 tttggggctc agtgcagttt ccagtctttt ttgtctttaa taacgtttca ttgttaaccc
     6241 ctactttcca ataacagcta aatccttaag tctttcttac gaaagggttt tgtgatatgg
     6301 ttaaaagaag caactaaagc tccacctaag aattctaatg aggaggactg atacccagta
     6361 cgcggtaagc gtcgttgtct tttgtgggga attttatgag agttaagagc attgttttta
     6421 gctgcaattc cttgatgagc aagcttttgt tgctgatttt gcttgacagg atgaggaaaa
     6481 ctataaaagc cttgatgaga aagattatga tttgaaaacg tcgttgcttt tttttcatag
     6541 tgaatgacgt gcatctgttg actatcatga tcgtagacag cggccagttt gtcattgttt
     6601 tctaacaagt cgatatcaag cttgctaata taggtttcaa attcttgacg agtcatattt
     6661 ggaagcatca tataggcata acgatcgcca tcttgagtat ggttttgcat gatagtgata
     6721 aaggtatttg aaacttcttt gatggcttct ggtgatttgt catcagcttt tatgttttgc
     6781 catttccctg tttgaagcgc cttacttatg ctaagtgttg ttggcttgaa gaagtagtaa
     6841 ccaatatttt gagcgggatc atcactttca aggaaaatac ttttagtgtt tgtaaaatca
     6901 actagctgat tattcaagtc aacgggttga ttgttaacat aagaacagta agggtgcttt
     6961 tgattttctt ttcgttgctc aatagttgta tacgccttgt gagatgactg gtttttgata
     7021 ttgctaccaa caaagattat tttgtttcct aagataaacc accctttatt gagagtgaga
     7081 cttttattcc aattagtgaa ggtcatagca gctagagcac ttgtattatt aagtttttta
     7141 cttgcaacaa aagcatcatc agagagacta gtcatgccaa cttgttgata gttcgtttta
     7201 atattctcag gagttccctc tagtggtttt tgctcagttt ctgtggttcc aggtaagcgg
     7261 tagggattta ccgttgccca atagttttca ctgtagtgtc ctaaatcgtt attgtatagg
     7321 taaaacattc catcagaagt aaaccagcca tgaagatttt cattattcat agcttcataa
     7381 ttttgagttc gattcgaaaa catggatagg ccaaaagcaa aatcgtgttt attattatat
     7441 agtgccaatt tatccatact attgaaacta gctacgtaac tatcaagttt ttggactgga
     7501 acagaagtat cacttagtag ctctttcata agtttgatat cgtgataggt tttcaaatta
     7561 tcatagacat tgtaaaaaac attcccttgt gtgacgagtg tttttatacg tgttttaagt
     7621 gccaaacggt gaggctcttc agacatgtca gcaatacgta aaatagcacg aagtgcttca
     7681 atgccagcaa catgagattg agcattaaaa cgactgatag aacgccctcg agtcatatcc
     7741 atcatttctc cacgaacgat gatagggaaa aaagaatggt taatccaatg ataaatagta
     7801 gccattttat ccgcttctat aggagatttt gttttttgaa taataggaat taattgcgat
     7861 aagccatcta taagcacatt accgtaagct ccagtgtaag caatgccttt tttataaagt
     7921 ggactttgag cattagtaac cacgtgatca attaaagaac cgtcttggta aaaaccattt
     7981 ccttcatcaa ctagcgtgaa aactttctca attgctttga ttgtatcact aatttcgaga
     8041 tcatctttac gaagaatacc ggaaatgagt ttaacacgtc ccatatcaat taaatttccg
     8101 ctattggctt caaaaggtgg aaaattggca gcgcgaaccc taaaacgagt agggtcaggc
     8161 acaaattttt cgattggagc tgtgtattta agaatttctt cttgagtaaa ataaggatac
     8221 atcaaggata aggtattatt aatagcacga ggagttccaa tttcataatc ccaccaattt
     8281 tctttgtttt cttttccagt tgtttgatga ttttcacgat ctagattata agcgtgttca
     8341 tacatgaagg ccataccgtc ttttacaata gcaatagctt tactatcttg ataatagcat
     8401 gattcaggat tagtgatctg ttttgctatt ttttcaatat tgcggtaagt tttcgtgata
     8461 ttagcagaag cggaataatc ctttgcatgt tcccaaaggt aagttctatt ttcgtggtca
     8521 ggctcttgat agcttttaat aatgttttga gcatcctttt cagctttatt atgaaaagtg
     8581 accatgtcag gattggtttt atcataagca tcgttgcctg cgataatact gttccattgg
     8641 tctaacaatt cagtatagta gtctttttgt tgtggctgta ctaccttttt ttcgctatct
     8701 gtagtagtga gagtttgcgt ttgaaagtaa gtattattag gttctgaatt tgaagtcagt
     8761 gtatcggcat aaatggcagt tccttggccc atcatagcaa agctaaggaa taggtttgaa
     8821 taaagtagta attgtttatg gtgtgtgcaa aaataagtat tcactgataa attcctccga
     8881 tataaaaatg agataataaa agtaaactgg tttactcagt aaaaatatac cacgttaaag
     8941 tgtttttgta aacccttaca taaataatag ctgagttttt gtgcactaat aagtgtaggt
     9001 actgaagatg tcatacagat aggacacttg tcatttaggc ttgttttcat tatactagag
     9061 aagtagatta catatttttg aaaggacttt tttcctatga aatacatcgt taacaaaagt
     9121 cacaatcctg cctttaacat cgctttggaa gcctatgctt ttagagaact agtggaagaa
     9181 gacgaattgt ttatcctttg gatcaatgag ccagctatta ttattggcaa acatcaaaac
     9241 accattcaag aaatcaataa agaatacatt gatgaacatg gtattcatgt tgtgcgacgt
     9301 ttatctggtg gtggtgcggt ttatcatgat ttgaataact tgaactacac tatcatttca
     9361 aataaaacag cggaaggcgc atttgatttc aaaaccttct cacaacctgt gattgcgacc
     9421 ttagctgact tgggcgtaac agccaacttt acaggccgta atgatattga aattgatggc
     9481 aaaaaaatct gtggtaatgc tcaagcttac tacaaaggtc gcatgatgca ccatggttgc
     9541 cttttgtttg atgtggatat gaccgttctt ggcgatgctc ttaaggtaag taaggataag
     9601 attgagtcta aaggagtgaa gtctgttcgt gcccgtgtga ccaatatttt aaatgaatta
     9661 ccagaaaaaa ttaccgttga ggaattttca gataaaatct tgaccaagat gaaagaaacg
     9721 tacccagaca tgacagaata tgtcttgtcg gaggatgagt tggctaagat tgaacaatct
     9781 gccaaagagc aatttggtag ctgggattgg acctacggca aagcgccaga atatacgatt
     9841 gaacgcaatg ttcgttaccc tgcaggtaaa atttcaacct ttgcaaatgt tgaaaattct
     9901 atcattaaaa accttaaaat ctatggtgat ttctttggaa tcaaagatgt gcaagacatt
     9961 gagaacttat taattggttg taaatatgag taccgtgatg tttttgaacg tttaaaaacg
    10021 attgatacga ctcagtactt ctcacgcatg accgttgaag aagttgctaa agctattgtt
    10081 tcttagtggt tttaatcact taagaagctc tgtcagaaga aaaaactata aaactcctaa
    10141 gcgaactatc gtgtcctact taggagtttt tgtttgatga catgaaagaa gaacttaaac
    10201 tttattaaag gaagctttgc ttttaaggtc ggcatattct tcagtgattt cttgtttcag
    10261 tatatcatca tagctaggta gtgaaatagc tgatccatac ttttttttaa gagctgttgt
    10321 tactaagcgg taagcaagat taacattgcg tgataagata ggaccgtgga aataactacc
    10381 atagacgttt ttatagtgaa caccttcagt ttggtcttct ttattattac cgttgccata
    10441 aaccactcgt ccaagtggct tttcgtcacc agataagaag gtacgtcctt gatgattttc
    10501 aaagccataa taggtttcgt taaattcgtc attatgaatt ttaatatctc caataaagcg
    10561 attttggtgc tgattaaggg tgtagtgtcc cataattcca agtccatcaa ttttaacccc
    10621 attagcttgg acatagtatt gccctagtaa ttggaagcca ccacagatgg caagcaccac
    10681 tttattatta gcaatgtaat ccgctaaggc agcttttttg ctaggcaaat ccttggcaac
    10741 aatgctttgt tcataatctt gaccaccacc aaagaaaaca atatcgtaat cgtcttgttc
    10801 aaaggtatca ttgatagaca caatatcaac agtaacccta gctccaagtt tttcagcgac
    10861 atacttgagc attaaaatat tgccgttatc accataagta ttcataagat taccatagag
    10921 atgggcgata ttgaggtcgt agatgtagtc ttgattttcg ggagatttta gtgaagtgta
    10981 tgtcattaga tcatctcctt ttcaacgaca tggcggtcag caagtaagct acggaattct
    11041 aacattgccg tataggttgc taaaatatag gcatgcttag cttcttgttt ttcaatggtt
    11101 tctatgattt gctcgagctt ttcagcttgc tttattttag tatcgtcaaa tcctgtgact
    11161 ctaagtcttc tagcaatttc agagtggcgg acgccgccag cattaatttc tgtaatgggc
    11221 atttgggtga tgagttcaaa attagcatcc caaatccagc tggtatcaat gccgtcagcg
    11281 taattagcat ttaaaagcac agataagcta aatgggtaat cagctagctg aatcatttca
    11341 agcgcttgac tggctccaac aggattcttg ataaggataa gggtgcatga tttatcacca
    11401 atagtaaaag tttcttgtct tccaaaaacc gccttacttt tgttaaagcc cgccttgatt
    11461 ttctcgggag aaacaccgaa aaattcagca acagagacgg cagcgagggc gttgtaaata
    11521 ttatataagc caccgacatt gattttgtaa tcttggccat caatgataaa ctcagaactg
    11581 tgattggtaa tcgtcgtgag ttcagttaat cgataatcca attgtggtct cttgaagcca
    11641 caatttaaac aaataaagtc tcctagattc gcataagtat tgagacgata ctgaagaata
    11701 tgttcgcatt ttggacataa aatcccttct gtgttgtaat gagctagctg cggagcatgc
    11761 ttagcagtat caaaaccata atactgaact ggattaacta tgtccttaga agagaaaata
    11821 ggactatctc cattggctag aatagttgct tttggagcat ttcgagcacc atctacaatc
    11881 atctgataag tagtataaat ctctccgtag cggtccatct gatccctaaa aatattagta
    11941 taaacaaaaa gactaggttt taagtaagtg gtaattttag gaagactagc ttcgtcaatt
    12001 tctaaaacag caatttgttt gccagatttt ccttttttag cagctaaaaa agtagaagta
    12061 attccagtaa tcatattggc accacttgga tttgtgatta tctcgccaaa tgcctctttc
    12121 aaaataccga cagtaagagc agttgttaac gttttaccat tagtaccagt gacgaccaca
    12181 atatcatagt ctttagacaa atcctttaaa atatctttat tacaagctag agccaatcga
    12241 ccaggataag tagatcctcg ccctagtttt gttaaaatgg attgagcagc tttgccagca
    12301 ataatgccga gtaatgtctt cattttcatg cttatatttt atcataagtt tattgatttt
    12361 agatagggaa aaatctttga tcatgatatg atataatata gctaataact tttttgatat
    12421 agaaatgaga gttgtatgaa taatttatct agtatcgata ttaaattttt attaagctta
    12481 tttgcggatc cttggctgct ggcagtgcat cttttagata ttctaattgt tgcctatttg
    12541 atttatcgtt ttattaaagc attgactgga actaaaatca tgtctttagt tcaaggggtc
    12601 attttctttt tggttcttcg ttttattgca gagtggattg gctttacgac aatcacatac
    12661 ttaatgaacc aagtcattac ttatggtgta attgcaggag tagtcatttt tacccctgaa
    12721 attcgggcag gactggagaa atttggtcgt tctacgcaag tttttttaca aaaacagtac
    12781 gtcagcagtg aatctgcttt ggtcgatgct ttgattaaat ctgtggccta tatgggtcca
    12841 cgcaagatag gtgcattgat tgctattgaa cagactcaaa ccttacaaga atatattgcg
    12901 acaggaattc cgctgaatgc cgacatttca agtcaactac tcatcaatat ttttattccg
    12961 aatacgccgc ttcatgatgg agctgttatc gttggtcaga ataagattgt ggcagcctgt
    13021 gcctacttgc ctttgtcaga atcaaaggca atttccaaag aatttggaac ccgtcataga
    13081 gcggctattg gattatctga aaactctgat gcactaacta tcattgtttc agaagaaaca
    13141 ggagctattt cagtaactcg caaaggccaa tttttacacg atttaagcac agatgaattt
    13201 gaaacggtac ttaggaccta cctgatgagt gattcaaatg ttagtttacc atggtataag
    13261 aaaattctag gagggaaatc taaatgaaac gatttttaaa tagtcgtcct tggttaggaa
    13321 tggtatcagt cttttttgcg attctccttt ttttaactgc agcatcgagc aatcataata
    13381 attctagctc gcaaatttac agcccgattg aaacctatac gcatagcctt aaagatgtac
    13441 caattgatat gaagtatgat agtgataaat attttatcag tgggtattct tatggtgcgg
    13501 aagtttatct aacctccact aatcgtatca aattagattc tgaagtgaac aatgatacac
    13561 gtaattttaa gattgtggcg gatctaacac atagtcatcc aggtacagta agtgtcaacc
    13621 taagagtaga aaacctccct tctggggtga cagctaccgt atctccagat aaaatatcag
    13681 tcacaattgg caaaaaagaa tctaaggtat ttcctgttag aggaagcgtt gatgctaaac
    13741 aaattgcaaa tggttatgaa attagcaaaa ttgaaacggg ggttaataag gttgaagtga
    13801 ccagtgatga atctaccatt gctttaattg atcacgttgt ggcaaagtta cctgatgatc
    13861 aagtgttaga taggaattat agtagtcgag tgaccttaca agctgtctca gctgatggaa
    13921 ctattttagc aagtgcaatt gatcctgcaa aaacaaattt atcagttgct gtaaaaaaaa
    13981 taacgaaatc agtcccgatt agagttgagg cagtggggat gatggatgat agcttatcag
    14041 atattcaata caaattgtca aaacaaacag ctgttatctc aggtagtcga gaggtcttag
    14101 aagatattga tgaaattatt gcagaagtta acatttctga tgtcactaaa aatactagta
    14161 agaccgtgag tttgtcttct agtcaggtgt caattgagcc gtcagtagtg accgttcagt
    14221 tgacaaccac caaaaaataa tggataataa ctaggaaaat tgaatggagg aagccattag
    14281 gcttatataa attatgggaa aatattttgg aacagatggt gttcgtggtg aagcaaatgt
    14341 tgagctgaca cctgagttag cttttaaact gggccgattc ggtggttatg ttttgagtca
    14401 acatgagacc gaaagaccta aagtttttgt ggcgcgtgac acccgtattt caggagaaat
    14461 gttggagtca gccttgattg ctggtctact atctgttggt attgaagttt ataaacttgg
    14521 tgttttagcg acacctggtg tctcttattt agttagaact gaaaaagcaa gtgcaggtgt
    14581 gatgatttct gcaagtcata accctgcgct tgacaatggc atcaaattct ttgggaatga
    14641 cgggtttaag ttagctgatg accaagaatt ggaaattgaa gctctcttag atgctccgga
    14701 ggacacgctt cctcgcccga gtgcagaagg acttggaacc ttggtagatt atccagaagg
    14761 acttcgtaaa tatgaaaagt tcttggtaac aacaggtact gacttaagcg gtatgacagt
    14821 tgccttagac actgctaatg gagctgcttc agtgtcagca cgtgatgtct ttttagattt
    14881 aaatgcagaa attgctgtca ttggcgaaaa accaaatggt cttaatatta atgacggtgt
    14941 tggttcaacg catccagaac aacttcaaga gttagttaag gaaacaggag cagatcttgg
    15001 tttagccttt gatggcgata gcgaccgtct gattgccgtg gacgaaactg gcgagattgt
    15061 tgacggtgat cgtattatgt ttatcattgg taaatacttg tcagaaaaag ggcttcttgc
    15121 tcacaatacc attgtcacaa cggtgatgtc taacctcggt tttcataaag ctttagataa
    15181 acaaggtatt aataaagcaa ttacagcagt tggagaccgc tatgtggttg aagaaatgcg
    15241 tagctcagga tacaatctcg gtggtgaaca atcaggccat gtcattatca tggactacaa
    15301 taccactgga gatggtcagt tgacagctat ccaattagcc aaggtgatga aggaaactgg
    15361 gaaatcactt tcggaattag ctgctgaagt aaccatttac cctcaaaaac tggtgaatat
    15421 tcgtgtggaa aacagcatga aagaccgtgc tatggaagtt ccagctattg cgaacatcat
    15481 tgcaaaaatg gaggatgaaa tggctggtaa tggtcgtatt ctcgtgagac caagtggtac
    15541 agaacctctt cttcgtgtca tggcagaggc gccaacagat gccgaagttg attattatgt
    15601 cgatactatt gctgatgtcg tccgtacaga aatcggatgc gataactaac gagttgagta
    15661 caaacaagaa accttatttc taaggcttct gtcaacaatt ggaaagaggc ttggggcgtt
    15721 tagcccaagt ctctttttat aaattgctaa agtagaagag aaaggatatc ggatgacaaa
    15781 acagcaaatc gaaaaactag cggacttact gcctcctttt gcagccacac tttacttaga
    15841 tatgattcct gaatttcagg aaggttatgc ttcatatgtt tatcaaaccc aaaaagaaga
    15901 tactcaaaac cgtcgcatca agcagttaac taaaaatttt gaacgattac tagatacccc
    15961 atctttttat gtgatgcctg tgacaagaaa aacagcagag caattgctag cagataaagg
    16021 cctagcttat catttgttat cgacagttgc agctaatcaa gtgtttgcgg ctgctgttaa
    16081 cgaggatcag acgctttttc aagtacttcg aaatggagca agagtagcct ttgtgattct
    16141 tcaagaaaag ggggaatttc tagaaatgac tttagggatt cttgaaacag tgacagaaaa
    16201 cgaggttcca gcagctattg tggaggctgt ccagacatat cttctggcag atatgcaaga
    16261 gaaacttcct tctttaagca ttatggtcag tcaagaatca agcaagcttt tttacaaaga
    16321 acaagggttt gttttgctag ctaagggttg caagccagga aacgaaaatg attctgacgt
    16381 ttgtcagctc gtaaaatact tttccaagcc atgaagaatc aagggaaatg gtttattcat
    16441 aaaaacattt tatcaccaaa gtgatataat aagaccatgt caaaaaaacc tacttcagcc
    16501 tatgtgcaca ttcctttttg cacacaaatt tgttattatt gcgatttttc aaaagtcttt
    16561 atccaaaatc aacctgttga tgcttatttg agagccttga ttcaagaatt tgactcttat
    16621 ggcattcgag acctaaaaac cctttatatt ggaggaggta cgcctacagc tatcactgct
    16681 aaacagttgg agtatctcct aaatcacctt gaacgaaacc tcaatttaga tgatcttgaa
    16741 gaattcacaa ttgaggcaaa tcctggtgat ttgacgccag aaaaaattgc ggtgcttcag
    16801 aggtcagctg tcaatcggat ttccttgggg gtgcagactt ttaataacaa gcaattaaag
    16861 cagattggcc gtagccataa tgaagaacaa atttatagca ccatcgctaa tttaaaagct
    16921 gcaggctttc acaatatttc cattgattta atttatgcct tgccaggtca aaccttagat
    16981 caagtcaagg aaaatgttgc taaagctttg gcacttgata ttccccacct tagtctttat
    17041 agccttattt tggaacatca cactgttttt atgaacaaaa tgcggcgtgg taaacttaac
    17101 ttaccaacgg aagacttgga agcagaaatg tttgagtata ttatttcaga aatggaagct
    17161 aatggctttg aacattatga aatctctaat tttaccaaac caggttttga aagtcgccat
    17221 aacttgatgt attgggataa tgtggagtat tttggatgtg gtgcaggggc ttcaggttac
    17281 cttaatggca ttcgttatca aaatcgggtg cccatccagc attatcttaa agcggttgaa
    17341 gcagggaatg ctagactaaa tgaagaagtg ctgcgcaaag aggaaatgat ggaagaggaa
    17401 ctctttttgg gcttacgtaa aaagacagga gtctccatcc agcggttcca agaaaaattt
    17461 ggtatgcctt ttgaggagcg ttatggaaat attgttaggg agcttcaaaa ccaaggactg
    17521 cttgtcaaag atgacgcctt tgtcagaatg actaaaaagg gtcttttctt aggtgattct
    17581 gttgctgagc ggtttatatt agattaggag agtattatgg gattaagtta tcaggaggag
    17641 ttgacacttc cttttgaatt atgtgatgtc aaatcagata taaaattgcc ccttttatta
    17701 gactattgtt tgatggtttc tggtagacag tctgcgcaat taggacgaag taacaacaac
    17761 cttttagttg attacaagct tgtttggatt gtaacggatt atgagatcac tattcatcgc
    17821 ttgccacatt ttcaagaaac catcaccatt gaaacaaaag ccctttccta taataaattt
    17881 ttttgttatc gccaatttta tatttatgat caagaggggt gccttttagt ggatatctta
    17941 gcctattttg ctttgttaaa cccagatacg cgaaaagtgg caactattcc agaagattta
    18001 gtagcgcctt ttaagactga ttttgttaaa aagctacacc gtgctcctaa aatgcctctt
    18061 ttagaacaat caattgatcg tgattattat gtgcgttatt ttgatattga tatgaatggt
    18121 catgtcaaca acagtaaata tttagattgg atgtatgatg tgttggggtg tgagttttta
    18181 aaaacgcatc agcctcttaa gatgactttg aaatatgtta aagaagtctc accaggcggt
    18241 caaattactt ccagttacca tttggaccaa ttaacttctt accatcaaat cacctcagat
    18301 gggcagctga atgcccaagc catgattgaa tggcgagcga ttaaacaaac agaaagtgag
    18361 acagactagt gccttataag ggttatttaa ttgatttaga cggaacgatt taccaaggga
    18421 aaaaccgtat tccagcaggg gagcggttta tcaaacgcct acaagaaaaa ggcattccct
    18481 atttattagt gactaataat accacaagaa cacccgaaat ggtgcaaagc atgctggcta
    18541 atcagtttca tgttgagaca ggcattgaga ccatttatac ggctaccatg gcaaccgtcg
    18601 attacatgaa tgacatgaac cgtggcaaaa cagcttacgt tattggagaa acagggctca
    18661 aatcagctat tgcagcagca ggttacgtag aagaacttga gaatcccgct tacgtggtgg
    18721 ttggtttaga cagtcaggtg acctatgaga tgttggctat agccaccttg gctattcaaa
    18781 aaggtgccct ctttattggg acaaatcctg atttaaacat tccaaccgaa cgtggtttga
    18841 tgccaggagc aggtgcattg aatgccttac tagaagctgc cacacgtgta aaacctgttt
    18901 ttattggcaa gcccaacgct atcattatga ataaatcact agaggtattg ggcattcagc
    18961 gctctgaggc tgtcatggtt ggcgataatt acttgactga tatcatggca ggtattcaaa
    19021 atgatattgc aacgatcctc gtgacaacag gctttaccag acctgaagag gtaccaacct
    19081 taccaattca gccagatcat gtcctatcta gccttgatga gtggaggttg tgatggtaga
    19141 aaacactaaa ttactatgta gctgggtatg gttattagcg ttagctattc tcataacgat
    19201 ctattcaacg tggctgtggt atcctcttga ggtggaccat ctaaagttag aacaagttgt
    19261 ttttatgagc aaggatgcta tcttgcataa ctataacgga ctactaaatt acctcaccaa
    19321 tccttttgtg acaaggttgg aatttgctaa ttttcactca tcagcagacg gactcaagca
    19381 ttttgcagat gtgaagtggc tttttcacct aactcaagtc gtttttcttg gcctccttta
    19441 cccaaccctt aagactttca cacaaaggtt aaaaaccaaa cgtttctggc tccttcaaaa
    19501 acctttaata ctagcagctt tgtttcctct tatgattggt ctaatggcta gtttcattgg
    19561 gtttgaacat ttttttactc tttttcatca ggtgcttttt gtaggagata gcagctggct
    19621 ctttgatccc ttgaaagatc ctgtgatttg gatccttcca gaagtctttt tcttgcactg
    19681 tttccttttc tttatgatag tttacgaaat catcctgtgg agcttagtag gtttagcaag
    19741 atggcagcgc ctaaatgtag aatgataaaa ggattaagag attaatttcc ctaaaaatga
    19801 taaaacaagc gttttgaaag cgcttgtttt ttagtttgca gtcagagtag aatagaagta
    19861 tcaaaaaaag caccgactcg gtgccacttt ttcaagttga taacggacta gccttatttt
    19921 aacttgctat gctgttttga atggttccaa caagattatt ttataacttt tataacaaat
    19981 aatcaaggag aaattcaaag aaatttatca gccata
//
LOCUS       DAUDWO010000037        19865 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.037, whole genome shotgun sequence.
ACCESSION   DAUDWO010000037 DAUDWO010000000
VERSION     DAUDWO010000037.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19865)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19865)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19865
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.037"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            211..1704
                     /gene="malQ"
                     /locus_tag="VHC05_001361"
     CDS             211..1704
                     /gene="malQ"
                     /locus_tag="VHC05_001361"
                     /EC_number="2.4.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-alpha-glucanotransferase"
                     /protein_id="HEQ5402662.1"
                     /translation="MNKRASGILIHISSLPGKFGIGTFGKSAFEFVDFLAETKQTYWQ
                     ILPLTTTSFGDSPYQSFSAIAGNTHFIDFELLVDDELLEAADLCDITFGTNPEAVDYA
                     QLFQVRRPLLEKAVRAFVAEQENVCKLEAFETASSWLTDFAEFMALKEYFNNKALQDW
                     DDETVIKRQEDSLNNYRELLAKKITYHKVCQYFFYQQWSALKTYANHKGIEIIGDMPI
                     YVSADSVEVWTMPELFKVDSDKKPLFIAGVPADGFSEDGQLWGNPTYNWSAHEKSNFA
                     WWIYRIQESFKLYDQLRIDHFKGFSDFWEIPAGDKTARNGHWASAPGIALFSAVREAL
                     GELPIIAENLGYIDEKAEQLLASTGFPGMKILEFGLFDITSQSIDLPHYYDRNCVAYT
                     GTHDNEVVNGWYDNLSEEQVHFVNNYLHKHADESITKAMLRTIFASVCDTAILCIQDL
                     LDKDGKSRMNMPNTIGGNWQWRMLDGELNQDHKDYLIYLTDLYGRAR"
     gene            1739..4003
                     /gene="glgP"
                     /locus_tag="VHC05_001362"
     CDS             1739..4003
                     /gene="glgP"
                     /locus_tag="VHC05_001362"
                     /EC_number="2.4.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan family
                     phosphorylase"
                     /protein_id="HEQ5402663.1"
                     /translation="MTRFTEYVETKLGKSLTQASNEEIYLSLLNFVKEEASHKAKNTA
                     KRKVYYISAEFLIGKLLSNNLINLGIYKDIKEELAAAGKSIAEVEDVELEPSLGNGGL
                     GRLASCFIDSISSLGINGEGVGLNYHCGLFKQVFKHNEQEAEPNYWIEDDSWLVPTDI
                     SYDVPFKNFTLKSRLDRIDVLGYKRDTKNYLNLFDIEGVDYGLIKDGISFDKTQIAKN
                     LTLFLYPDDSDKNGELLRIYQQYFMVSNAAQLIIDEAIERGSNLHDLADYAYVQINDT
                     HPSMVIPELIRLLTEKHGFDFDEAVAVVKNMVGYTNHTILAEALEKWPTAYLNEVVPH
                     LVTIIEKLDALVRSEVSDPAVQIIDESGRVHMAHMDIHFATSVNGVAALHTEILKNSE
                     LKAFYDLYPEKFNNKTNGITFRRWLEFANQDLADYIKELIGDEYLTDATKLEKLMAFA
                     DDKAVHAKLAEIKFNNKLALKRYLKDNKDIELDEHSIIDTQIKRFHEYKRQQMNALYV
                     IHKYLEIKKGNLPKRKITVIFGGKAAPAYIIAQDIIHLILCLSELINNDPEVSPYLNV
                     HLVENYNVTVAEHLIPATDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIA
                     ELAGMENIYTFGKDSDTIINLYATASYVAKDYYDNHPAIKAAVNFIISPELLAFGNEE
                     RLDRLYKELISKDWFMTLIDLEEYIEVKEKMLADYEDQDLWMTKVVHNIAKAGFFSSD
                     RTIEQYNEDIWHSR"
     gene            complement(4260..4880)
                     /locus_tag="VHC05_001363"
     CDS             complement(4260..4880)
                     /locus_tag="VHC05_001363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3862 domain-containing protein"
                     /protein_id="HEQ5402664.1"
                     /translation="MTKKHLLTLLLISFFTSFLVACSTTKDKEPQPSDSENITPRLHQ
                     AAHQDKRANFEKIKLATVDSSFTGGTSLEELISLFGEPNQHDPKTAGEVTIDAYTWQF
                     DQVTLTVNLYQNSSIVKTISNFTFARELGLSQKEYQQLQKGMSYEDVKKILTEPDNYS
                     QASSSDHQTLQAIWVSGLKTDTSGANISLVFENNQLTEMSQVGLEE"
     gene            complement(5182..5529)
                     /gene="ssrA"
                     /locus_tag="VHC05_001364"
     tmRNA           complement(5182..5529)
                     /gene="ssrA"
                     /locus_tag="VHC05_001364"
                     /product="transfer-messenger RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00023"
     gene            5621..6235
                     /locus_tag="VHC05_001365"
     CDS             5621..6235
                     /locus_tag="VHC05_001365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HEQ5402665.1"
                     /translation="MTKRNSKAYILWQKIIKILGIIALIGTFFLAFWLYRLGILNDSN
                     ALKDLVQRYRLWGPFVFIVVQIIQIVFPVIPGGLTTVAGFLIFGPVTGFIYNYVGIII
                     GSIVLFLLVKTYGRKFILLFVNDKTFYKYERRLETPGYEKLFIFCMASPVSPADIMVM
                     ITGLTDMSLKRFVTILLITKPISIIGYSYLFIFGKDVISWFLQH"
     gene            complement(6362..7147)
                     /locus_tag="VHC05_001366"
     CDS             complement(6362..7147)
                     /locus_tag="VHC05_001366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989610.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402666.1"
                     /translation="MFGKLLKYEFRSIGKWYFALNAFVIAIAAILSFTIKLFAQSNSD
                     GLFGVLTNKMLPLTLGLTFGSLIAGSLLSTLLIIIKRFSKSVFGREGYLTLTLPVNSH
                     QIILSKLLASFICSVFNTIILAFAIAIVIVPMFNVNELLEGFFNSFKMDYFINMLTVL
                     AYVLLSTFTSILLIYLSISIGQLFSNRRGLMAFIAYFILVILISVAATYVHNHIFNIN
                     TSADSFPFTEQKTTYLLILEQFIEMIMFYLATNFIIKNKLNLQ"
     gene            complement(7157..7855)
                     /locus_tag="VHC05_001367"
     CDS             complement(7157..7855)
                     /locus_tag="VHC05_001367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402667.1"
                     /translation="MAHLLQLHHVSKSYREKKAIDDLTITIPNGKIIGLLGPNGSGKT
                     TLIKLINGLLQPNKGEIVIDGYRPCVETKKIISYLPDTTYLNENMRIKDMLEFFSDFY
                     SDFDKSKATSLLRDLELDPEDRFKTLSKGNKEKVQLILVMSRKARLYVLDEPIGGVDP
                     AARDYILKTIINSYCENASVIISTHLISDIEPILDEVIFLKQGRLFLSGNADDLRQEY
                     QQSIDSLFRETYKV"
     gene            complement(7855..8226)
                     /locus_tag="VHC05_001368"
     CDS             complement(7855..8226)
                     /locus_tag="VHC05_001368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEQ5402668.1"
                     /translation="MSWKFDEKSPIYAQIAQHVMMQIISQEIKSGDQLPTVREYAEIA
                     GVNPNTMQRAFTELEREGMVYSQRTAGRFVTDDQKLIARKRRELAISELESFITNMTK
                     MGFNHTEIIPVLTSFLKEDSQ"
     gene            8411..11521
                     /locus_tag="VHC05_001369"
     CDS             8411..11521
                     /locus_tag="VHC05_001369"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="HEQ5402669.1"
                     /translation="MFAQLDTKTVYSFMDSLIDLNHYFERAKQFGYHTIGIMDKDNLY
                     GAYHFIKGCQKNGLQPVLGLEVEILYQERQVLLNLIAQNTQGYHQLLKISTAKMSGKL
                     HMDYLCQHLEGIAVIIPSKGWSDTLVVPFDYYIGVDQYTDLSHMDSKRQLIPLRTVRY
                     FAQDDMETLHMLHAIRDNLSLAETPVVESDQELADCQQLTTFYQTHCPQALQNLEDLV
                     SGIYYDFDTNLKLPHFNRDKSAKQELQDLTEAGLKEKGLWKEPYQSRLLHELVIISDM
                     GFDDYFLIVWDLLRFGRSKGYYMGMGRGSAAGSLVAYALNITGIDPVQHDLLFERFLN
                     KERYSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGPKQAIRDVFKRFGV
                     PEYELTNLTKKIGFKDSLATVYEKSISFRQVINSRTEFQKAFAIAKRIEGNPRQTSIH
                     AAGIVMSDDTLTNHIPLKSGDDMMITQYDAHAVEANGLLKMDFLGLRNLTFVQKMQEK
                     VAKDYGCQIDIAAIDLEDPQTLALFAKGDTKGIFQFEQNGAINLLKRIKPQRFEEIVA
                     TTSLNRPGASDYTTNFIKRREGQEKIDLIDPVIAPILEPTYGIMLYQEQVMQIAQVYA
                     GFTLGKADLLRRAMSKKNLQEMQKMEEDFIASAKHLGRAEETARGLFKRMEKFAGYGF
                     NRSHAFAYSALAFQLAYFKAHYPAVFYDIMMNYSSSDYITDALESDFQVAQVTINSIP
                     YTDKIEASKIYMGLKNIKGLPRDFAYWIIEQRPFNSVEDFLTRTPEKYQKKVFLEPLI
                     KIGLFDCFEPNRKKILDNLDGLLVFVNELGSLFSDSSFSWVDAKDYSATEKYSLEQEI
                     VGVGMSKHPLIDIAEKSTQTFTPISQLVKESEAVVLIQIDSIRIIRTKTSGQQMAFLS
                     VNDTKKKLDVTLFPQEYAIYKDQLKEGEFYYLKGRIKERDHRLQMVCQQVQMAISQKY
                     WLLVENHQFDSQISEILGAFPGTTPVVIHYQKNKETIALTKIQVHVTENLKEKLRPFV
                     LKTVFR"
     gene            11601..12614
                     /gene="pfkA"
                     /locus_tag="VHC05_001370"
     CDS             11601..12614
                     /gene="pfkA"
                     /locus_tag="VHC05_001370"
                     /EC_number="2.7.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HEQ5402670.1"
                     /translation="MKRIAVLTSGGDAPGMNAAIRAVVRKAISEGMEVYGINRGYAGM
                     VDGDIFPLGSKEVGDKISRGGTFLYSARYPEFAQLEGQLAGIEQLKKHGIEGVVVIGG
                     DGSYHGAMRLTEHGFPAVGIPGTIDNDIAGTDYTIGFDTAVNTAVEAIDKLRDTSSSH
                     GRTFVVEVMGRNAGDIALWAGIASGADQIIVPEEEFDIEKVASTIQYDFEHKGKNHHI
                     IVLAEGVMSGEAFAQKLKEAGDKSDLRVTNLGHILRGGSPTARDRVIASWMGSHAVEL
                     LKEGKGGLAVGIHNEELVESPILGTAEEGALFSLTEEGKIIVNNPHKARLDFAALNRS
                     LSQ"
     gene            12677..14179
                     /gene="pyk"
                     /locus_tag="VHC05_001371"
     CDS             12677..14179
                     /gene="pyk"
                     /locus_tag="VHC05_001371"
                     /EC_number="2.7.1.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018366040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate kinase"
                     /protein_id="HEQ5402671.1"
                     /translation="MNKRVKIVATLGPAVEIRGGKKYGEDGYWAGQLDVEESAKKIAE
                     LIEAGANVFRFNFSHGDHKEQGDRMATVRLAEEIARQKVGFLLDTKGPEMRTELFADD
                     AKEFSYVTGEKIRVATTQGIQSTRDVIALNVAGSLDIYDEVEVGHTILIDDGKLGLKV
                     IDKDIATRQFIVEVENDGIIAKQKGVNIPNTKIPFPALAERDNADIRFGLEQGLNFIA
                     ISFVRTAKDVEEVREICRETGNDHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMG
                     IEVPFEMVPVFQKMIITKVNAAGKAVITATNMLETMTEKPRATRSEVSDVFNAVIDGT
                     DATMLSGESANGKYPVESVRTMATIDRNAQTLLNEYGRLDSSAFPRTNKTDVIASAVK
                     DATHSMDIKLVVTITETGNTARAISKFRPDADILAVTFDEKVQRALMINWGVIPVLAE
                     KPASTDDMFEVAERVAVEAGLVQSGDNIVIVAGVPVGTGGTNTMRVRTVK"
     gene            14397..14954
                     /gene="lepB"
                     /locus_tag="VHC05_001372"
     CDS             14397..14954
                     /gene="lepB"
                     /locus_tag="VHC05_001372"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HEQ5402672.1"
                     /translation="MVKRDFIRNILLLLIVVIGAILLRIFVFSTFKVSPETANTYLKS
                     GDLVTIKKNIQPKYKDFVVYRVGKKDYVSRVIAVEGDSVTYMDDIFYLNNMVESQAYL
                     EKMKAHYLNHAPFGTLYTDDFTVATITADKYQKVPKGKYLLLNDNRKNTNDSRRFGLI
                     NASQIKGLVTFRVLPLSDFGFVEVE"
     gene            15130..16944
                     /gene="glmS"
                     /locus_tag="VHC05_001373"
     CDS             15130..16944
                     /gene="glmS"
                     /locus_tag="VHC05_001373"
                     /EC_number="2.6.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019804802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="HEQ5402673.1"
                     /translation="MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNL
                     IKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLVHNGVI
                     ENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFA
                     LMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKD
                     KVTVTDYDGKELIRDSYTAELDLSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETG
                     NVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTPVELGVASEWGYHMP
                     LLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSREATYTMLIHAG
                     PEIAVASTKAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKD
                     LVAEKVQALLATTRNAFYIGRGNDYYVAMEAALKLKEISYIQCEGFAAGELKHGTISL
                     IEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIVNKVHPF
                     LAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE"
     gene            17140..17475
                     /locus_tag="VHC05_001374"
     CDS             17140..17475
                     /locus_tag="VHC05_001374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkylphosphonate utilization protein"
                     /protein_id="HEQ5402674.1"
                     /translation="MSLPNCLQCQSEYVYEDGLLLICPMCAFEWTPGEEATEEEGLVA
                     LDSNGVRLSDGDTITVIKDLKVKGAPKDLKQGTRVKNIRLVEGDHNIDCKIDGFGAMK
                     LKSEFVKKI"
     gene            17582..18223
                     /locus_tag="VHC05_001375"
     CDS             17582..18223
                     /locus_tag="VHC05_001375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019323647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEQ5402675.1"
                     /translation="MTYIQQVLPSLLDGALVTLQVFFIVIILSIPLGAILAFLMKVPF
                     KPLQWFLTLYVWMMRGTPLLLQLIFFYYVLPSVGISFDRMPAAILAFTLNYAAYFAEI
                     FRGGIEAIPKGQYEAAKVLKLKPLQTIRYIILPQVFKIVLPSVFNEVINLVKDSSLVY
                     VLGVGDLLLASKTAANRDATLAPMFIAGLIYLLLIGLVTIISKQVEKRFNYYQ"
     gene            18233..18862
                     /locus_tag="VHC05_001376"
     CDS             18233..18862
                     /locus_tag="VHC05_001376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009854102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402676.1"
                     /translation="MLELKNISKQFGQKTIFDGFNLTVQDGEVLSLVGPSGGGKTTLL
                     RMLAGLESIDSGQVFYNGEDVGIDHLENRNLLGFVFQDFQLFPHLTVLDNLTLSPTIT
                     MGKQKADAKEKALDLLARLGLKEHAQVYPYSLSGGQKQRVALARAMMIDPQIIGYDEP
                     TSALDPELRQTVESLIVQNREMGITQIVVTHDLVFAEAISDRIIRVNPK"
     gene            18878..19714
                     /locus_tag="VHC05_001377"
     CDS             18878..19714
                     /locus_tag="VHC05_001377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEQ5402677.1"
                     /translation="MIIKKRTVAILAIASSFFLVACQATKSLKSGDAWGVYQKQKSIT
                     VGFDNTFVPMGYKDESGKCKGFDIDLAKEVFHQYGLKVNFQAINWDMKEAELNNGKID
                     VIWNGYSITKERQNKVAFTDSYMRNEQIIVVKKRSDIKTISDMKHKVLGAQSASSGYD
                     SLLRTPKLLKDFIKNKDANQYETFTQAFIDLKSDRIDGILIDKVYANYYLAKEGQLEN
                     YRMIPTTFENEAFSVGLRKEDKTLQAKINRAFRVLYQNGKFQAISEKWFGNDVATANI
                     KS"
BASE COUNT         6308 a         3293 c         4006 g         6258 t
ORIGIN      
        1 gatattatca attccaatga acagaatctt agtcagacta tttttgttcc ttttagttta
       61 aaacaaagag aaagcgtccg tgatattagt cattaagaac aaaaaaagta gcatttttaa
      121 ggaatgttac tttttttagg aaactggttg acttacgcaa gcgcttgcgt tataatctca
      181 tcatgaatag atttcacaag gagaaaaatc atgaacaaac gtgcaagcgg tatcttaata
      241 catattagtt ccctgcctgg gaaatttggg ataggcactt ttggaaaatc agcttttgaa
      301 tttgttgatt ttctagcaga gacgaaacaa acctattggc aaattctgcc tttaacaacg
      361 acgagttttg gagattctcc ttatcagtca ttttcagcta ttgctgggaa cacacatttc
      421 attgattttg aattgctagt agatgatgaa cttttagaag cagcagattt gtgtgatatt
      481 acattcggca caaatcctga agcagtagac tatgctcagc tttttcaagt taggcgtcca
      541 cttttagaaa aagcagtgag agcttttgtt gctgaacaag aaaatgtgtg taaattagaa
      601 gcttttgaaa cagcttctag ctggttaact gattttgctg aatttatggc tttaaaagaa
      661 tattttaaca ataaagcctt acaagattgg gacgacgaaa ctgtcattaa acgccaagaa
      721 gactcactta ataattaccg tgagttgctt gcaaaaaaga ttacctatca taaagtctgt
      781 caatacttct tttaccaaca atggtcagcc ttgaaaactt acgctaacca taaagggata
      841 gaaattattg gtgatatgcc tatttatgtt tctgcggaca gtgtagaagt ttggacgatg
      901 cctgagctat ttaaagtaga tagtgataaa aagccattgt ttattgcagg tgtaccagca
      961 gatggcttta gtgaagatgg tcagctgtgg ggaaatccaa cctacaattg gtctgctcat
     1021 gaaaagtcta attttgcatg gtggatttat cgtattcaag aaagtttcaa actatatgat
     1081 cagctaagaa tcgatcattt taaaggcttc tcagattttt gggaaattcc tgctggtgat
     1141 aaaactgcta gaaatggcca ttgggcctca gccccaggta tagcgttatt ttctgcggtt
     1201 cgtgaggcct taggagagct tcctatcatc gcagaaaacc ttggttatat tgatgaaaaa
     1261 gcagagcagc tattagcatc aacaggcttt cctggcatga agatattaga atttggttta
     1321 tttgatataa cgagtcaaag tatagatttg ccacattact atgaccgtaa ttgtgtcgct
     1381 tacacaggga ctcatgataa cgaggtggtt aacggatggt atgacaatct tagtgaagaa
     1441 caagtacact ttgtaaataa ctatcttcac aaacatgcag atgaaagtat tacaaaagcc
     1501 atgctaagaa caatctttgc ttctgtttgt gatacagcca ttctttgcat ccaagattta
     1561 ttagataaag atggtaagag tcgtatgaat atgccaaata caattggagg taattggcaa
     1621 tggcgtatgc ttgacggtga attgaaccaa gatcacaaag actaccttat ttatttaaca
     1681 gatctttatg gtcgcgcaag ataatattta aatgttacat tattgaaaag aggaagacat
     1741 gacacgcttt acagaatatg ttgaaactaa actaggaaaa tcacttacgc aagccagcaa
     1801 tgaagagatt tatctatcat tattaaactt tgtcaaagaa gaagctagcc acaaagctaa
     1861 aaatactgcc aaacgcaaag tttactatat ctcagcagag tttttgattg gtaaattact
     1921 atcaaacaac ctgattaacc taggaattta caaagatatc aaagaagaat tggcagctgc
     1981 tggcaaatct atcgcagaag tcgaagatgt tgaattagaa ccatcactag ggaatggtgg
     2041 tttaggacgt ttggcatcat gtttcattga ctctatttca tctcttggta ttaatggtga
     2101 aggggttggt ttaaactatc attgtgggtt gtttaagcaa gtcttcaaac acaatgagca
     2161 agaagctgag ccaaactact ggattgaaga tgactcatgg ttggttccaa cagacatttc
     2221 ttacgatgtg cccttcaaaa actttacctt aaaatctcgt cttgatcgta ttgatgtttt
     2281 gggttacaaa cgtgacacta aaaactacct taacttgttt gatatcgagg gcgttgatta
     2341 cgggttaatc aaagacggta tttcatttga taaaacgcaa attgctaaaa acttgacctt
     2401 gttcctctac ccagacgatt ctgacaaaaa tggggaattg ctccgtattt accaacagta
     2461 ctttatggtg tcaaatgcag cgcaattaat cattgatgaa gctatcgaac gtggttcaaa
     2521 ccttcatgac cttgcagact acgcttacgt gcaaattaat gacacgcatc catcaatggt
     2581 tattcctgaa ttaattcgtc tcttgactga aaaacatggc tttgactttg atgaagcggt
     2641 agctgttgtg aaaaatatgg ttggttacac taaccacact attcttgcag aagcccttga
     2701 aaaatggcca actgcttact taaacgaagt agtgccacac ttggtaacca tcattgaaaa
     2761 attggatgct cttgttcgtt cagaagtgtc tgacccagct gttcaaatta ttgacgaatc
     2821 aggtcgtgtg cacatggccc atatggatat tcattttgca acaagtgtca atggggtagc
     2881 agcactccac acagaaatct tgaaaaacag cgaattaaaa gctttctatg acctttaccc
     2941 agaaaaattc aacaacaaaa ccaacgggat tactttccgt cgttggctag aatttgctaa
     3001 ccaagacttg gctgattaca ttaaagaact tattggcgat gagtacttga ctgacgcaac
     3061 aaaactagaa aaattgatgg cctttgcaga tgacaaagct gttcatgcta aattggctga
     3121 aatcaaattc aacaacaaat tagctcttaa acgttacctt aaagacaata aagacattga
     3181 gcttgatgaa cattctatta ttgataccca aatcaaacgt ttccacgagt acaaacgtca
     3241 acagatgaat gctctttacg tgattcacaa atatttggaa attaaaaaag gcaaccttcc
     3301 aaaacgtaaa atcactgtta tctttggagg taaagcagcg cctgcttaca tcattgctca
     3361 agacatcatt cacttgatcc tttgcttgtc tgaattgatt aacaatgacc ctgaagtaag
     3421 cccatacctt aatgtgcatc tagttgaaaa ttacaacgtg acagtagcag agcacttgat
     3481 tccagcaact gatatttctg agcaaatttc actagcatcc aaagaagctt ctggaactgg
     3541 taatatgaaa ttcatgctta acggtgcttt aacacttggt acaatggacg gtgctaacgt
     3601 agaaatcgct gagcttgcag gcatggagaa tatctatacc tttggtaaag attctgacac
     3661 catcatcaac ctttatgcga ctgcttctta tgtagcaaaa gattactatg ataaccaccc
     3721 tgctattaaa gcagcagtga actttattat cagtccagaa ttgctagcat ttggcaacga
     3781 agaacgtctt gatcgtcttt ataaagaatt gatttcaaaa gactggttca tgactttgat
     3841 tgaccttgaa gagtacattg aagtgaaaga aaaaatgtta gcagactacg aagaccaaga
     3901 tttgtggatg acaaaagtgg ttcacaacat tgccaaagct ggattcttct catctgaccg
     3961 taccattgaa cagtataacg aagatatttg gcattcacga taaaaaataa taattgcaat
     4021 gtggggtagc ggtaccgtaa catgcttaaa ctaaattata agacagtagt ttctgctgtt
     4081 ttatgatttt acttcagact taggttaatt attacattaa gcgtaaagca agtctgttta
     4141 tcgatctatg gaggtaatta taagaaacta cactaaagtt ttttattaaa atgatataaa
     4201 aagattgatt tcgatgtaca ccgaaatcaa tctttttagc aaaatatatt acgcattttt
     4261 tattcttcaa gtcctacctg agacatttct gttaactgat tattttcaaa aacgagagaa
     4321 atattagctc cgcttgtatc tgtctttaag ccactaaccc aaatcgcttg caaagtttga
     4381 tgatcactag atgacgcttg gctataatta tcaggttctg ttaagatctt tttaacgtct
     4441 tcataagaca ttcctttttg taattgttgg tattcttttt gcgataagcc taactctctt
     4501 gcaaaggtaa aattagagat ggttttaaca atactactat tttgataaag attaacagtg
     4561 agagtaactt gatcaaactg ccaagtataa gcgtcgattg ttacttcgcc tgctgttttt
     4621 ggatcatgtt ggttaggctc tccaaagagt gaaataagtt cttcaaggct tgttcctcct
     4681 gtaaatgagg aatcaacagt cgcaagttta attttttcaa agttagcgcg tttatcttga
     4741 tgagcggctt ggtgtagtcg gggagtaatg ttttctgaat cagacggttg aggctcttta
     4801 tctttcgttg ttgaacaagc taccaaaaag ctagtaaaaa aagagatgag aagaagtgtt
     4861 agtaagtgtt tttttgtcat atgttatttc ctaaactatt tttgctgtat tatatcataa
     4921 attataaaca agatatagct atgattcccc ataacgcatg cgctatgggg aatttagtac
     4981 tattttgatt ctttttttta gatattcatg aaaaaaatgg tcaaaaagct ctgatatgac
     5041 aaggttttga gtggtattga tggagtatcg gtaagcgtga tggtatggct atagggataa
     5101 cggaaactca tgaacaagac aaaaagaaaa aaccttgatg taacaaggtt ttagtaagtt
     5161 atgattactt acggtaagca ttgatggagc tggtgggagt cgaacccacg tccaaacacc
     5221 tgccaacata tttgtctacg tccataggtt atgtcttcat ttaacaaact aaagacacat
     5281 aactcaagcc attagtttgc gagtctatca atctcctgtc acggaactag acaatttcgt
     5341 aaccgtagct tgctattttg agacttctaa caggacacaa gcaatcttgt agaagtcacg
     5401 ctagctggtt tttaggcagc taaagcgtaa gagtttgtat tttttgcagt tatatttaac
     5461 tggcaattta catctgccga tgggacgcaa aacatgcctc ataatgcctg tcgaatccgt
     5521 aacaacccca aatagataat taaccaattt cttacactaa ctattctatc aaaacttttt
     5581 ttaaatagca aaattttaca gcttatggta tgattagtct atgacaaaac gtaattcaaa
     5641 agcctatata ttatggcaaa aaattatcaa aattttagga attattgcat taattggtac
     5701 ttttttcctc gctttttggc tgtatagact aggtatatta aacgatagta atgctcttaa
     5761 agacttagtg cagcgctata gattatgggg gccgtttgtt tttattgtcg tgcagatcat
     5821 acagattgtt tttcctgtga ttcctggagg ccttacgaca gttgcaggtt ttttaatctt
     5881 tggccctgta acaggtttta tttataatta tgtaggcatc attattggca gtatagtcct
     5941 cttcttgctt gttaagactt atggtcgtaa atttatctta ctctttgtaa atgacaaaac
     6001 attttacaag tacgaaaggc gtttggagac accaggatat gaaaaattat ttattttttg
     6061 tatggcatcg cctgtttctc cagctgatat tatggttatg attacgggat tgacggacat
     6121 gtctttaaag cgctttgtaa ctattctttt aataactaaa ccaatttcta ttatcggcta
     6181 cagttattta tttatttttg gaaaagatgt tatatcttgg ttcttacagc attaaggttt
     6241 ggtgttaatt tgataaaccg cttctatttg atggaagacg gttttttaat ttactatgaa
     6301 cactgaaaaa aactttcttt taaactatag tgtgtcatag tttaaaagaa agtcttaacg
     6361 cttactgtag gttgagttta tttttgataa taaaattagt ggcgaggtaa aacattatca
     6421 tttcaataaa ttgttccaaa ataagaagat aagttgtttt ttgctcagta aatgggaaac
     6481 tatcggcact tgtattaata ttaaagatgt gattgtgaac atatgttgca gcaacgctaa
     6541 tcagaataac taatataaaa tatgcaataa aggccatcaa gcctcgccga ttagaaaaaa
     6601 gttgacctat agaaatggaa agataaatta ataagatact cgtaaatgtt gataatagga
     6661 cataggctag tacagttagc atattgatga aataatccat cttaaaacta ttaaagaatc
     6721 cttctaatag ttcgttgacg ttaaacattg gtacaattac aatagcgata gcaaatgcaa
     6781 ggatgatagt attgaaaaca ctgcaaataa aagaagctag tagttttgat aaaataattt
     6841 gatgcgaatt gacgggtaaa gtcaacgtta agtatccttc ccgtccaaaa acacttttgc
     6901 taaaacgttt gataatgata agtaatgttg ataagaggga gccagcgatc agggagccaa
     6961 aagttaaacc taatgtcaga ggcaacatct tattggttag tactccaaat agtccatcac
     7021 tattgctttg agcaaacagt tttatcgtaa atgacaaaat ggcagcgatg gcaataacga
     7081 aagcattaag cgcaaagtac cattttccaa tagatctaaa ttcgtatttt aataattttc
     7141 caaacatgat atcctcctaa accttataag tttccctaaa gagggaatca atagattgct
     7201 ggtattcttg tcttagatca tcagcattgc cagataagaa aagtcttcct tgtttcaaga
     7261 aaatgacttc gtcaaggata ggttcaatgt ccgaaatcaa gtgggttgag ataataacag
     7321 aagcattttc acaataacta ttaatgatgg tttttaggat gtagtctctt gcggcagggt
     7381 caactccacc aataggttca tcaagtacat agagtctggc tttacgactc atcacaagaa
     7441 ttaattgtac tttttctttg tttcctttgg atagagtttt gaagcggtct tcagggtcta
     7501 gttctaaatc tcttagaagg cttgttgctt tggatttgtc aaagtcgctg taaaaatcac
     7561 taaagaactc caacatgtcc ttaattctca tattttcatt gagataagta gtatctggta
     7621 aataagaaat aatttttttt gtctcaacac agggacggta gccatcaatg acaatttctc
     7681 ctttatttgg ttgtaaaagg ccattaatga gtttaattaa agttgtttta ccacttccat
     7741 ttggacctaa taatccgata attttaccgt tcgggatagt aatggttaag tcatcaatag
     7801 cttttttttc acggtaagat tttgaaacat gatgtagttg caataggtgt gccattattg
     7861 tgaatcctcc tttaaaaagc tcgtcaaaac agggataatc tcagtgtgat taaatcccat
     7921 ttttgtcata ttggtgataa atgattctaa ttcactaatt gctaactctc gtcttttacg
     7981 agcaattaat ttttgatcgt cagttacaaa acggccagca gtacgttgcg aataaaccat
     8041 tccttcccgt tcaagttctg taaacgctcg ttgcatggtg ttaggattga cacctgcgat
     8101 ttctgcatat tcacgaacag ttggaagttg atcaccactc ttgatttctt ggctaataat
     8161 ttgcatcatg acatgttgtg ctatctgcgc ataaatagga gatttttcat caaatttcca
     8221 agacatgtgg tctcctttct gagtaatata gatatttgta ctaattaaat ggtacagaaa
     8281 aaaaagggga atgtcaagtt ttatgccatt tttcactctt tgagaagtag acgtagatta
     8341 gagagaaaat tgaagcaaga aaaccttttt catagtataa tagggaacaa gataaccaaa
     8401 ggaggaactt atgtttgctc aacttgatac taaaactgta tactcattta tggatagttt
     8461 aattgactta aatcattatt ttgaacgagc aaagcaattt ggttaccaca ccataggaat
     8521 catggataag gataatcttt atggtgctta ccattttatt aaaggttgtc aaaaaaatgg
     8581 actgcagcca gttttaggtt tggaagtaga gattctctat caagagcggc aggtgctcct
     8641 taacttaatc gcccagaata cacaaggcta tcatcagctt ttaaaaattt ccacggcaaa
     8701 aatgtctggc aagcttcata tggattacct ctgccaacat ttggaaggga tagcggttat
     8761 tattcctagt aaaggttgga gcgatacatt agtggtccct tttgactact atatcggtgt
     8821 tgatcagtat actgatttat ctcatatgga ttctaagagg cagcttatac ccctaaggac
     8881 agttcgttat tttgcgcaag atgatatgga aaccctgcac atgttgcatg ccattcgaga
     8941 taacctcagt ctggcagaga cccctgtggt agaaagtgat caagagttag cagattgtca
     9001 acaactaacc accttctatc aaacacactg ccctcaagct ctacagaatt tagaagactt
     9061 agtgtcagga atctattatg atttcgatac aaatttaaaa ttgcctcatt ttaatagaga
     9121 taagtctgcc aagcaagaat tgcaagactt gactgaggct ggtttgaagg aaaaaggatt
     9181 gtggaaagag ccttatcaat cgcgcttact gcatgaattg gtcattattt ctgacatggg
     9241 ctttgatgat tattttttga ttgtgtggga tttacttcgc tttggacgca gtaaaggcta
     9301 ttatatgggt atgggacgtg gctcggcggc aggtagtcta gtggcttatg ctctgaacat
     9361 tacagggatt gatccagttc aacatgattt gctatttgag cgctttttaa acaaagaacg
     9421 ttatagcatg cctgatattg atatcgatct tccagatatt taccgttcag aatttctacg
     9481 gtatgtccga aatcgttatg gtagcgacca ttcggcgcaa attgtgacct tttcaacctt
     9541 tggacctaaa caggctattc gtgatgtttt caaacgattc ggggttccag aatacgaact
     9601 gaccaatctc actaaaaaaa ttggttttaa agatagcttg gctactgtct atgaaaagtc
     9661 aatctctttt aggcaggtta ttaatagtag aactgaattt caaaaggcct ttgccattgc
     9721 caagcgtatc gaaggaaatc caagacaaac gtccattcat gcagctggta ttgtgatgag
     9781 tgatgatacc ttgaccaatc atattcctct aaaatcgggc gatgacatga tgatcaccca
     9841 gtatgatgct catgcggtcg aagctaatgg cctgttaaaa atggattttt tggggttaag
     9901 aaatttgacc tttgttcaaa aaatgcaaga gaaggttgct aaagactacg ggtgtcagat
     9961 tgatattgca gccattgatt tagaagaccc gcaaacgttg gcactttttg ctaaagggga
    10021 taccaaggga attttccaat ttgaacaaaa tggtgctatt aatcttttaa aacggattaa
    10081 gccacaacgt tttgaagaaa ttgttgccac taccagtcta aatagaccag gggcaagtga
    10141 ctataccact aatttcatta aacgaagaga aggacaagaa aaaattgatt tgattgatcc
    10201 tgtgattgct cccattttag agccaactta cggtattatg ctttatcaag aacaagttat
    10261 gcagattgca caagtttatg ctggttttac gttaggcaag gccgacttgt taaggcgtgc
    10321 catgtctaaa aaaaatctac aagaaatgca aaaaatggaa gaagacttta ttgcttctgc
    10381 taagcaccta gggagagctg aagaaacagc tagaggactt tttaaacgga tggaaaaatt
    10441 tgcaggttat ggttttaacc gcagccatgc ctttgcctat tcagctttag cttttcaatt
    10501 ggcttatttc aaagcccatt acccggctgt tttttacgat atcatgatga attattctag
    10561 cagtgactat atcacagatg ctctagaatc agattttcaa gtagcgcaag ttaccattaa
    10621 tagtattcct tacactgata aaattgaagc tagcaagatt tacatggggc tgaaaaatat
    10681 taaggggttg ccaagggatt ttgcttattg gattattgag caaagaccat ttaatagtgt
    10741 agaggatttt ctcactagaa ctccagaaaa atatcaaaaa aaggttttcc ttgagcctct
    10801 gataaaaata ggtctgtttg attgctttga gcctaaccgt aaaaaaattc tggacaattt
    10861 ggatggttta ctggtatttg ttaatgagct tggttctctt ttttcagatt cttcctttag
    10921 ttgggtagat gcgaaagatt actcagcaac tgaaaaatat tctttggaac aggagatcgt
    10981 tggggttggc atgagcaagc atcctttaat tgatattgct gagaaaagta cccaaacttt
    11041 tactcccatt tcacagttag tcaaagaaag cgaagcagtc gtactgattc aaatagatag
    11101 cattaggatc attagaacca aaacaagtgg gcagcaaatg gcttttttaa gtgtgaatga
    11161 cactaagaaa aagctcgatg tcacactttt tccacaagag tatgctattt ataaagacca
    11221 attaaaagaa ggagaattct attacttaaa aggtagaata aaagaaagag accatcgact
    11281 gcagatggtg tgtcagcaag tgcaaatggc tattagtcaa aaatattggt tattagttga
    11341 aaaccatcag tttgattccc aaatttctga gattttaggt gcctttccag gaacgacacc
    11401 agttgttatt cactatcaaa aaaataagga aacaattgca ttaactaaga ttcaggttca
    11461 tgtaacagag aatttaaagg aaaaacttcg tccttttgtt ctgaaaacgg tttttcgata
    11521 aaaatggaca attagtgaag tattttgcaa atgaatgtgc tataataaga ccgttaaatt
    11581 aattaaagga gtaccagaaa atgaaacgta ttgctgtttt aaccagtggc ggcgacgctc
    11641 ctggtatgaa tgctgctatt cgtgcagtcg ttcgtaaagc aatttcagaa ggaatggaag
    11701 tttatggtat caaccgtggc tatgcaggta tggttgatgg cgacattttc ccactgggtt
    11761 caaaagaagt tggtgataaa atctcacgtg gtggaacttt cttatactca gctcgttatc
    11821 cagaatttgc tcaacttgaa ggtcaattgg ctggtattga gcaacttaaa aaacatggta
    11881 ttgagggtgt tgttgttatt ggtggggatg gttcttatca tggcgctatg cgcttgacag
    11941 agcacggctt cccagcggta ggtatcccag gaacaatcga taacgatatt gcgggaactg
    12001 actacactat cggatttgat acagcagtta acacagcagt tgaagctatt gataaacttc
    12061 gtgacacctc atcaagtcac ggacgtactt ttgtggttga agtgatgggt cgcaatgcgg
    12121 gtgatattgc tctttgggca ggtattgcta gtggtgctga tcaaatcatt gttccagaag
    12181 aagagtttga tattgaaaaa gtggcatcaa caatccaata tgattttgaa cacaaaggta
    12241 aaaatcacca cattatcgtc ttagctgaag gtgttatgag cggtgaagct tttgctcaaa
    12301 aactgaaaga agctggcgat aagagtgacc ttcgtgtgac aaatcttggt cacattcttc
    12361 gtgggggttc accaactgct cgtgaccgtg tcattgcttc ttggatgggt tcacatgctg
    12421 ttgagctact taaagaaggc aaaggtggtt tggctgttgg tattcacaat gaagaacttg
    12481 ttgaaagccc aatccttggt actgcagaag aaggtgcttt gttcagcttg actgaagaag
    12541 gcaagattat tgttaataat ccacacaaag ctcgtttaga ctttgcagct ttgaaccgtt
    12601 cattgtcaca ataagtttag ttaaaattgt taaatcgtca attattgaca aaaaaataag
    12661 ggagtttcag agtaaaatga ataaacgcgt aaaaatcgtt gcaacacttg gtcctgcggt
    12721 tgaaatccgt ggtggtaaaa aatacggaga agatggctac tgggctggtc aacttgatgt
    12781 tgaagaatca gcaaaaaaaa tcgctgaatt aattgaagct ggtgcgaatg ttttccgttt
    12841 caatttctca catggtgacc acaaagaaca aggtgaccgt atggcaactg ttcgccttgc
    12901 agaagaaatt gctcgtcaaa aagttggttt ccttttggat actaaaggtc ctgaaatgcg
    12961 tacggaattg tttgcagatg atgctaaaga attcagctat gtcactggag aaaaaatccg
    13021 tgtagcgact acacaaggta ttcaatcaac tcgcgatgtt attgctttga acgttgctgg
    13081 tagccttgac atctacgatg aagtagaagt aggtcatact attcttatcg atgatggtaa
    13141 acttggtttg aaagtgatcg acaaagatat cgcaacacgt caatttatcg ttgaagtaga
    13201 aaacgacggt attattgcta aacaaaaagg tgttaatatc cctaacacta aaattccttt
    13261 cccagcactt gcggaacgcg acaatgctga tatccgtttt ggtcttgaac aaggacttaa
    13321 ctttattgca atctcatttg ttcgtacagc caaagacgtt gaggaagttc gtgaaatctg
    13381 tcgcgaaact ggtaacgacc atgtgcaatt atttgctaag attgaaaacc aacaaggtat
    13441 cgataatctt gatgaaatca tcgaagctgc tgatggtatc atgattgcac gtggcgacat
    13501 gggtatcgaa gtaccatttg aaatggttcc agttttccaa aaaatgatta tcactaaagt
    13561 gaatgcagct ggtaaagcag ttatcacagc aacaaacatg cttgaaacaa tgactgaaaa
    13621 accacgtgcg acacgttctg aagtatctga cgtcttcaat gctgttatcg atggtactga
    13681 tgcaacaatg ctttcaggag agtcagctaa cggtaaatac ccggttgaat ctgttcgtac
    13741 aatggcgact attgatcgta atgcacaaac tcttcttaac gaatatggtc gtttagattc
    13801 atctgccttc ccacgtacca ataaaacaga tgttattgct tcagctgtta aagatgccac
    13861 tcattcaatg gacatcaaac ttgttgtgac tattactgag acaggtaata cagctcgtgc
    13921 gatttctaaa ttccgtccag atgcggatat cttagctgta acatttgatg aaaaagtaca
    13981 acgtgctttg atgattaact ggggtgttat tcctgttctt gctgaaaaac ctgcatctac
    14041 tgatgacatg tttgaagtag cagagcgtgt tgctgtggag gcaggcttag ttcaatctgg
    14101 ggataatatt gttattgttg ctggtgttcc agttggtact ggtggaacga atactatgcg
    14161 tgttcgtaca gtaaaataaa tgtgttataa ctatctacct aaaggttaga aggcaagctt
    14221 ctaacctttt ttgatatcaa aaatatcatg ttaattcact agtgttaatt tactttaatg
    14281 agtctaagtt tgtattttat acagaatgag taacgtttat tggtattgat caaaaattgt
    14341 ttactttttt tctagcttag aacatggtat aataagacaa tagactagga gttaatatgg
    14401 taaagcgaga ttttataaga aatatattat tgttattaat tgtggttatt ggggctattt
    14461 tgttgagaat ctttgttttt tcaactttta aagtttctcc agaaacagct aatacttatt
    14521 taaagagtgg tgatttagtc acaatcaaaa aaaatattca gcccaaatat aaagattttg
    14581 tggtttatag agttggaaaa aaagattatg tcagtcgagt cattgctgtt gaaggcgata
    14641 gcgtgactta tatggatgat attttttacc tcaataatat ggtagagtca caggcttacc
    14701 ttgaaaagat gaaagcacat tacttgaatc atgcaccgtt tggcacattg tatacagatg
    14761 attttacagt tgctaccatc acagctgata agtatcaaaa agttcctaag gggaagtatc
    14821 ttcttttgaa tgataaccgg aaaaatacga atgacagtcg tcgatttggg ttaataaatg
    14881 cctcgcagat taaaggttta gtgaccttta gagttttgcc tctcagcgat tttggatttg
    14941 tagaagtaga gtagttgtca ggctactcta ctttttttat aattagacta taccaatttt
    15001 atgtttgaca agacattgtg ggtattatat actgtaaaca taatgttttt atcggtataa
    15061 tatgactata ccaattattg aaattatgag agaaagtagc aagttaacga acttgttaag
    15121 gtaattaaga tgtgtggaat tgttggagtt gttggaaatc gcaatgcaac ggatatttta
    15181 atgcaaggcc ttgaaaagct tgaataccgg ggttatgatt cagcaggaat ttttgtggct
    15241 aatgccaatc aaacaaactt gattaaatca gtggggcgga ttgctgattt gcgtgccaag
    15301 attggcattg atgttgctgg ttcaacaggg attggtcaca cccgttgggc aacgcatggc
    15361 caatcaacag aggataatgc ccatcctcac acgtcacaaa ctggacgttt tgtacttgtt
    15421 cataatggtg tgattgaaaa ttaccttcac attaaaacag agttcctagc tggacatgat
    15481 tttaaggggc agacagatac tgagattgca gtacacttga ttggaaaatt tgtggaagaa
    15541 gacaagttgt cagtactgga agcttttaaa aaagctttaa gcattattga aggttcctat
    15601 gcctttgcgt taatggatag ccaagcaact gatactattt atgtggctaa aaacaaatct
    15661 ccattgttga ttggacttgg tgaaggttac aacatggttt gttcagatgc catggccatg
    15721 attcgtgaaa ccagtgaatt tatggaaatt catgataagg agctagttat tttaaccaaa
    15781 gataaggtaa ctgttacaga ctacgatggt aaagagctga tacgagattc ctacactgct
    15841 gaattagact tatctgatat tggcaaaggg acttatcctt tctatatgct gaaagaaatt
    15901 gatgagcaac caaccgtaat gcgtcaatta atttcaactt atgcagatga aactggtaac
    15961 gtacaggttg atccagctat cattacctct atccaagagg ctgaccgtct ttatatttta
    16021 gcggcaggga cttcctacca tgctggtttt gcaacaaaaa atatgcttga gcaattgaca
    16081 gatacaccag ttgagttggg agtggcttct gagtggggtt accacatgcc tctgcttagc
    16141 aagaaaccaa tgtttattct actaagccaa tcaggagaaa ccgcagatag tcgtcaagtt
    16201 ttagtaaagg caaatgctat gggcattccg agtttgacag taactaacgt tccaggatca
    16261 accttatcac gtgaagcaac atacaccatg ttgattcatg ctggacctga aattgctgtt
    16321 gcgtctacaa aagcttacac tgcacaaatt gctgcccttg cctttttggc taaggcagtt
    16381 ggtgaggcaa atggtaagca agaagctctt gactttaact tggtacatga gttgtcattg
    16441 gttgcccaat ctattgaggc gactttgtct gaaaaagatc tcgtggcaga aaaggttcaa
    16501 gctttgctag ctactactcg taatgctttt tacatcgggc gtggcaatga ttattacgtt
    16561 gcgatggaag ctgctttgaa attaaaagag atttcttata ttcaatgcga aggctttgcg
    16621 gctggtgaat tgaaacatgg aaccatttca ttaattgagg aggacacgcc agtaatcgct
    16681 ttaatatcgt ctagtcagtt ggttgcctct catacgcgtg gtaatattca agaagttgct
    16741 gcccgtgggg ctcatgtttt aacagttgtg gaagaagggc ttgaccgtga gggagatgac
    16801 attattgtca ataaggttca tcctttccta gccccgattg ctatggtcat tccaactcaa
    16861 ctgattgctt actacgcttc attacaacgt ggacttgatg ttgataagcc acgtaatttg
    16921 gctaaagctg taacagtaga ataaatgatt ataatggata aggcaaccat ctgttaggtg
    16981 gttgcttttt gtttttagga gaatagcaga gcttagaaaa tggccttgag aaaagctata
    17041 caagaagaat agtcatcttc tgatgagaac gtattcatct tgtcaaatca ttgattctaa
    17101 agtaaaatgg taacattaag aaatgtttag gagtgtaaga tgtcattacc aaattgtttg
    17161 caatgccagt ctgaatatgt ttacgaagat ggtcttttat taatctgtcc aatgtgtgct
    17221 tttgagtgga caccaggtga ggaagcgact gaagaagaag gacttgttgc tttagatagc
    17281 aatggtgttc gattgtctga tggcgatact attactgtta ttaaagattt aaaagttaaa
    17341 ggtgctccaa aagacctgaa acaagggact cgtgttaaaa atattcgcct ggtggaaggt
    17401 gatcataaca ttgattgtaa gattgatggg tttggcgcga tgaaattgaa atcagaattt
    17461 gtcaagaaaa tctaataata atacgcaacc agctgatctg gttgtatttt tataaaaaaa
    17521 tctctcccca aatacgttca aatttggtat aatagtaaaa tattcagttt taggaggcaa
    17581 catgacctat attcagcaag ttttacccag cttattagat ggtgccttgg tgaccttaca
    17641 agtattcttt attgttatca ttctttctat acccttaggg gctattttag ctttcttgat
    17701 gaaggttccc tttaaaccgc tacagtggtt tttgacccta tacgtgtgga tgatgcgagg
    17761 gacaccatta ctacttcaat tgattttttt ctattatgtt ttgccaagtg tggggattag
    17821 ttttgatcga atgccagctg ctattttggc gtttactttg aattatgctg cctactttgc
    17881 tgaaattttt agaggtggga ttgaggctat tccaaaaggt caatatgaag cagctaaagt
    17941 attaaagtta aaacctcttc aaaccattcg ttatattatt ttgcctcaag tgtttaaaat
    18001 tgtgttacca agtgttttca atgaagtcat taatttggtc aaagattctt cccttgtcta
    18061 tgtactcggt gtaggagatc ttttattagc aagtaagacg gcagccaata gggatgcaac
    18121 cttagcccct atgtttatcg ctggtcttat ctatttgctt ttaattggac tggtcacgat
    18181 tatttcaaaa caagttgaaa aacggtttaa ttattatcag taaggaggct tcatgttaga
    18241 actcaaaaat atttccaaac agtttggtca aaaaaccatt tttgatggct ttaatctaac
    18301 cgttcaagac ggagaagtgc tctctctggt aggcccatca ggaggcggta agacaacact
    18361 cttacggatg ttagcaggtc ttgaatctat tgattcaggt caagtctttt acaatggaga
    18421 agatgttggt attgatcatt tggaaaatcg taacttgctt ggatttgttt ttcaagattt
    18481 tcaattgttt cctcatctta ccgttttaga caacctaacg ctgtctccaa caattacaat
    18541 gggcaagcaa aaggctgacg ctaaagaaaa ggctttggat ttactggcac gtttaggatt
    18601 aaaagaacat gcccaagttt atccctattc gttatctgga ggtcaaaaac aacgggttgc
    18661 tttggcaaga gccatgatga ttgaccctca aattatcggt tacgatgaac cgaccagtgc
    18721 tctagatcct gaattacgtc agacggtaga atccttgatt gttcaaaacc gtgaaatggg
    18781 aataactcaa attgtagtca ctcacgatct tgtttttgcc gaagccatct cagatcgtat
    18841 tattagggtt aatcctaaat agaagaggac ccaaaagatg attataaaaa aaagaaccgt
    18901 agcaatttta gccatagcta gtagcttttt cttggtagct tgtcaagcta ctaaaagtct
    18961 taaatcagga gatgcttggg gagtttacca aaagcaaaaa agtattacag ttggttttga
    19021 caatacgttt gttcctatgg gctataagga tgaaagcggc aaatgcaaag gttttgatat
    19081 tgatttggct aaagaagttt ttcaccaata tggactcaag gttaattttc aagctattaa
    19141 ttgggacatg aaagaagcag aactaaacaa tggtaaaatt gatgtaatct ggaatggtta
    19201 ttcaataact aaggagcgtc agaataaggt tgcctttact gattcttaca tgagaaatga
    19261 acaaattatt gttgtcaaaa aaagatctga tattaaaaca atatcagata tgaaacataa
    19321 agtgttagga gcacaatcag cttcatcagg ttatgactcc ttgttaagaa ctcctaaact
    19381 gctgaaagat tttattaaaa ataaagacgc taatcaatat gaaaccttta cacaagcttt
    19441 tattgattta aaatcagatc gtatcgatgg aatattgatt gacaaagtat atgccaatta
    19501 ctatttagca aaagaagggc aattggagaa ttatcggatg atcccaacga cctttgaaaa
    19561 tgaagcattt tcggttggac ttagaaaaga agacaaaacg ttgcaagcaa aaattaatcg
    19621 tgctttcagg gtgctttatc aaaatggcaa atttcaagct atttctgaga aatggtttgg
    19681 aaatgatgtt gccactgcca atattaaatc ttaaaaagga cacttgtcct tttttgttta
    19741 acaggtgaga tctagcagac aaagtcagct agacgattta ataaaaatct tagtttaagg
    19801 ttttttatta aactgtattt tttctaaaaa ttatagcttt tttagactga taaatgacaa
    19861 gaaaa
//
LOCUS       DAUDWO010000038        19538 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.038, whole genome shotgun sequence.
ACCESSION   DAUDWO010000038 DAUDWO010000000
VERSION     DAUDWO010000038.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19538)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19538)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19538
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.038"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            525..1052
                     /locus_tag="VHC05_001378"
     CDS             525..1052
                     /locus_tag="VHC05_001378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqeG family HAD IIIA-type phosphatase"
                     /protein_id="HEQ5402678.1"
                     /translation="MSIDDYRPTYMVEAIYDLRANDLLRHGITAVLVDLDNTLIAWNN
                     PDGTPEVRAWLDEMTIADISVVVVSNNKHSRVERAVSRFGVDFISRALKPFAYGIEKA
                     IARYGFDRNEVIMVGDQLMTDIRASHRAGIKSVLVKPLVASDAWNTKINRWRERRVMA
                     KLEEKYGKLSYQKGI"
     gene            1052..2170
                     /gene="yqeH"
                     /locus_tag="VHC05_001379"
     CDS             1052..2170
                     /gene="yqeH"
                     /locus_tag="VHC05_001379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018363769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YqeH"
                     /protein_id="HEQ5402679.1"
                     /translation="MEELFCIGCGIQIQTEDKEKAGFTPAAALKKGMETGELYCQRCF
                     RLRHYNEITDVHITDDEFLRLLHEVGDSDALVVNVIDIFDFNGSIIPGLSRFISGNDV
                     LLVGNKKDILPKSVKDGKVTQWLTERAHEEGLRPLDVMLTSAQNKYAIKDLIERINEL
                     RNGRDVYVVGVTNVGKSTLINAIIQEITGDKDVITTSRFPGTTLDKIEIPLDDGSFIF
                     DTPGIIHRHQMAHYLSPKELKIVSPKKEIKPKTYQLNSEQTLFLGGLSRFDFINGERQ
                     GFTAFFDNQLELHRTKLDGADAFYDKHVGTLLTPPGKKELTAFPKLVRHEFTIDQKMD
                     IVFSGLGWIRVNGQKDSKAIVAAWAPEGVAVIVRKAII"
     gene            2195..2503
                     /gene="yhbY"
                     /locus_tag="VHC05_001380"
     CDS             2195..2503
                     /gene="yhbY"
                     /locus_tag="VHC05_001380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003101715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome assembly RNA-binding protein YhbY"
                     /protein_id="HEQ5402680.1"
                     /translation="MLTSKQRAFLKSEAHSLKPIVQIGKNGLNDHIKTSIRQALDARE
                     LIKVTLLQNTDEDIHEVAEILEEEIGCDTVLKIGRILILYKVSAKKENRKLSPKVKAI
                     "
     gene            2572..3204
                     /locus_tag="VHC05_001381"
     CDS             2572..3204
                     /locus_tag="VHC05_001381"
                     /EC_number="2.7.7.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002313156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="HEQ5402681.1"
                     /translation="MALELLTPFTKVELEEEKKESNRKQIGILGGNFNPIHNAHLVVA
                     DQVRQQLGLDQVLLMPECKPPHVDAKETIDEKHRLRMLELAIEDVEGLAIETCELERQ
                     GISYTYDTMLYLTEQHPDVDFYFIIGADMVDYLPKWHRIDELVKLVQFVGVQRPKYKA
                     GTSYPVIWVDLPLMDISSSMIRDFIKKGRQPNYLLPKRVLDYITQEGLYQ"
     gene            3201..3794
                     /gene="yqeK"
                     /locus_tag="VHC05_001382"
     CDS             3201..3794
                     /gene="yqeK"
                     /locus_tag="VHC05_001382"
                     /EC_number="3.6.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="HEQ5402682.1"
                     /translation="MTYEDYLPYSRTELLAKIAEQMSPKRFKHVLGVEKAALSLAECY
                     GCNPDKAGLAALLHDYAKECSDQVFLDLIDKYQLSPELAKWNNNVWHGMVGIYKIQED
                     LGLQDKEILRAIEIHTVGAAEMTLLDKVLYVADYIEEGRIFPLVDDARKIAQLDLDKA
                     VAYETVNTVAYLASKAQPIFPQTLDTYNAFCSYLKEK"
     gene            3821..4030
                     /locus_tag="VHC05_001383"
     CDS             3821..4030
                     /locus_tag="VHC05_001383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003055729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isochorismatase family protein"
                     /protein_id="HEQ5402683.1"
                     /translation="MIGMLTNYCMDMTVRVAFELGYEVSVIEHGSTTFDDEDIQASLL
                     IDYHESLWDGNFARVEPLDVILNEE"
     gene            4032..4385
                     /gene="rsfS"
                     /locus_tag="VHC05_001384"
     CDS             4032..4385
                     /gene="rsfS"
                     /locus_tag="VHC05_001384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003049699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome silencing factor"
                     /protein_id="HEQ5402684.1"
                     /translation="MKKEELLEIVVKAADEKRAEDMLALDLEGLTSLTDYFVIASATN
                     SRQLEAIADNIREKVKEAGGDASHIEGDSQAGWVLLDLTDVVVHIFSEDERYHYNLEK
                     LWHEAPAVALDAYLA"
     gene            4433..5176
                     /locus_tag="VHC05_001385"
     CDS             4433..5176
                     /locus_tag="VHC05_001385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEQ5402685.1"
                     /translation="MEHNYEKFASVYDAVMDDSLYDLWTDFSLRHLPKSKGRNRLLEL
                     ACGTGIQSVRFAQAGFDVTGLDLSQDMLTIAEKRAQSAKKKIDFIQGNMLDLSQVGQF
                     DFVTCYSDSICYMQDEPEVGDVFKEVYDVLADDGIFIFDVHSTYQTDECFPGYSYHEN
                     ADDFAMVWDTYADEAPHSVVHELTFFIQEDDGRFSRFDEVHEERTYELLTYDILLEQA
                     GFKSFKVYADFEDKEPTETSKRWFFVAYK"
     gene            5430..6536
                     /locus_tag="VHC05_001386"
     CDS             5430..6536
                     /locus_tag="VHC05_001386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HEQ5402686.1"
                     /translation="MTVTGIIAEFNPFHNGHKYLLETAEGLKIIAMSGNFMQRGEPAL
                     IDKWIRSEMALKNGADIVVELPFFVSVQSADYFAQGAIDILCQLGIQQLAFGTENVID
                     YQKLIKVYEKKSKQMTAYLSTLEDTLSYPQKTQKMWEIFAGVKFSGQTPNHILGLSYA
                     KASAGKHIQLCPIKRQGAAYHSKDKNHLLASASAIRQHLNDWDFISHSVPNAGLLINN
                     PHMSWDHYFSFLKYQILNHSDLTSIFQVNDELASRIKKAIKVSQNIDHLVDTVATKRY
                     TKARVRRILIYILVNAKEPTLPKGIHILGFTSKGQAHLKKLKKSRPLITRIGAETWDE
                     MTQKADSIYQLGHQDIPEQSFGRIPIIIKKERLN"
     gene            7018..7734
                     /locus_tag="VHC05_001387"
     CDS             7018..7734
                     /locus_tag="VHC05_001387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008088325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEQ5402687.1"
                     /translation="MGRKWANIVAKKTAKDGATSKIYAKFGVEIYVAAKQGEPDPELN
                     TALKFVIDRAKQAQVPKHVIDKAIDKAKGNTDETFVEGRYEGFGPNGSMIIVDTLTSN
                     VNRTAANVRTAYGKNGGNMGASGSVSYLFDKKGVIVFAGDDADSVFEQLLEADVDVDD
                     VEAEEGTITVYTAPTDLHKGIQALRDNGVEEFQVTELEMIPQSEVVLEGDDLETFEKL
                     IDALESDDDVQKVYHNVADF"
     gene            7937..8779
                     /locus_tag="VHC05_001388"
     CDS             7937..8779
                     /locus_tag="VHC05_001388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012766588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEQ5402688.1"
                     /translation="MIKKQYLGRATIALASTLVLAACGSSKTAESGNQGSSKEVLFAT
                     VGTTAPFSYEKGGQLTGYDIEVAKAVFKGSDDYKVSFKKTEWSSIFTGLDSGKYQMGG
                     NNISFTKERSAKYLFSYPIGSTPSVLVVPKDSDIKSFDDIQGHTTQVVQGTTSVAQLE
                     DFNKKHSDNPVTLKFTNENITQMLTNLSEGKADFKIFDAPTVNAIIKNQGLDNLKTIE
                     LTSTEQPFIYFIFSQDQEKLQSFVNKRIKELTADGTLSKLTKEHLGGDYVPSDKELKL
                     PTAN"
     gene            9106..9951
                     /locus_tag="VHC05_001389"
     CDS             9106..9951
                     /locus_tag="VHC05_001389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HEQ5402689.1"
                     /translation="MSFKKWIGIVGIALASTVLVACSEKQDDKNTLTIGVMTKTESDQ
                     ARWDKVEELLKKDNITLKYKEFTDYSQPNKAVANGEVDINAFQHYNFLNNWNKENKEH
                     LVAIADTYISPINLFSGTSQDGNAKYKSVADLPNGAQIAVPNDATNESRALYVLQSAG
                     LIKLNVSGDQLATIANISENKKKLDIKELDASQTARALVSADAAVVNNSYAVPAKIDY
                     KTSLFKEKADDNSKQWINIIAGQKDWEKSEKADAIKKLIKAYQTDEVKKVVEKTSNGI
                     DVSVW"
     gene            10201..11265
                     /locus_tag="VHC05_001390"
     CDS             10201..11265
                     /locus_tag="VHC05_001390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402690.1"
                     /translation="MNEAIIQLDHIDITFHQKKRVIEAVKDVTVHINQGDIYGIVGYS
                     GAGKSTLVRVINLLQAPTNGKITVDGDVTFDQGKIQLSAEALRQKRRDIGMIFQHFNL
                     MAQKTAKENVAFALRHSSLSKTEKEQKVIELLELVGLSERADNYPAQLSGGQKQRVAI
                     ARALANDPKILISDEATSALDPKTTKQILALLQELNRKLGLTIVMITHEMQIVKDICN
                     RVAVMQNGVLIEEGPVLDIFSNPKEALTQEFITTATGIDEALEKINQQDIVKHLPANA
                     LLAQLKYAGTSTDEPLLNSIYRQFEVTANILYGNIEILDHIPVGDMIVVLEGQAENIL
                     AAEKALHEAGVDVSILKRGA"
     gene            11266..11958
                     /locus_tag="VHC05_001391"
     CDS             11266..11958
                     /locus_tag="VHC05_001391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991072.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402691.1"
                     /translation="MSQLIQTYLPNVYELGWSGDAGWGLAIWNTLYMTIVPFIVGGAI
                     GLLLGLLLVLTGPDGVIENKTICWVIDKVTSIFRAIPFVILIAILASFTYLLLRTTLG
                     ATAALVPLTFATFPFYARQVQVVFSELDKGVIEAAQASGATFWDIVKVYLSEGLPDLI
                     RVSTVTLISLVGETAMAGAIGAGGLGNVAISYGYNRFNNDVTWVATIIILLIIFAIQF
                     IGDSLTRRFSHK"
     gene            complement(12012..13382)
                     /gene="brnQ"
                     /locus_tag="VHC05_001392"
     CDS             complement(12012..13382)
                     /gene="brnQ"
                     /locus_tag="VHC05_001392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HEQ5402692.1"
                     /translation="MKQKNVYIVIGFMLFALFFGAANLIYPAFLGIYSGHQILWSIIG
                     FCLTGVSLPLLGVIAVAKSGSGDVESLARPISKWYAIFYSSILYLSIGPFFAIPRTGA
                     TSFSVGIAPILGDNTTNKAIYAILFFGLSYFLAIKPSKLAENIGKFLTPTLLVVISIL
                     VIASFVHPAGNYGDAFNAGVGVNNAFKDFPFIAGLIQGYGTMDALASLVFAILVIEAT
                     KQFGAKTDKEVTKITLISGAIAILLLALVYIFVGRIGATSQSLFPFIDGSFTLHGNPV
                     NGGQILSHASRFYLGGIGQAFLAVVIFLACLTTSTGLITSSAEYFHKLVPALSHIAWA
                     TIFTLLSAFFYFGGLSVIINWSAPVLFLLYPLTVDLIFLVLAQKCFNNDPIVYRTTIG
                     LTFIPAIFDALLTLSQMTGLFHLPEDVVTFFQKTVPLGQFSMGWIIFAAIGFLIGLIL
                     SKTKKS"
     gene            13616..14830
                     /gene="sstT"
                     /locus_tag="VHC05_001393"
     CDS             13616..14830
                     /gene="sstT"
                     /locus_tag="VHC05_001393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012516260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine transporter SstT"
                     /protein_id="HEQ5402693.1"
                     /translation="MKKIYDLWVRVSLIKKIGIGVVIGVMLGILAPDLTGFSILGKLF
                     VGGLKAIAPLLVFALVSQAISHQKKGRQTNMTLIIFLYLFGTFASALVAVLTAYLFPL
                     TLVLNTPVNTELSPPQGVAEVFQSLLLKLVDNPINALATANYIGVLSWAIIFGLALKA
                     ASQETKHLIKTAAEVTSQIVVWIINLAPIGIMSLVFTTISENGVGILSDYAFLILVLV
                     GTMVFVALVVNPLIAVLITRQNPYPLVLRCLRESGLTAFFTRSSAANIPVNMQLCQKI
                     GLSKDTYSVSIPLGATINMGGAAITINVLTLAAVHTFGIPIDFLTALLLSVVAAVSAC
                     GASGVAGGSLLLIPVACSLFGISNDLAMQVVGVGFIVGVIQDSCETALNSSTDVLFTA
                     IAENAFWKRKKA"
     gene            complement(14885..15559)
                     /locus_tag="VHC05_001394"
     CDS             complement(14885..15559)
                     /locus_tag="VHC05_001394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkA family potassium uptake protein"
                     /protein_id="HEQ5402694.1"
                     /translation="MLKRKTVGVLGLGIFGRTVARELSNFDQDVIAIDIRESHVKEVA
                     DLVTKAAVGDITDKEFLLAVGIEHCDTVVIASGNNLESSVLAVMHCKKLGVPTIIAKA
                     KNKIFEEVLYGIGATKVITPERDSGKRVASNLLRRHIESIIYLEHGISMIEFIIPKSW
                     EGQSLSELDVRRKYELNIIGMRQKEVKTLDTNVKPFEPLEPNTIIVAIANDHTFEKFD
                     YLGYLK"
     gene            complement(15569..16960)
                     /locus_tag="VHC05_001395"
     CDS             complement(15569..16960)
                     /locus_tag="VHC05_001395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HEQ5402695.1"
                     /translation="MSGGNMKRSFIKSLSVTQRLTFSFAIVILIGTLLLSMPFTHYQN
                     GPNTVYLDHFFNVVSMVCVTGLSVVPVAEVYNGIGQTIAMALMQIGGLGLVTLIAVST
                     FALKRKMRLSDQTLLQSALNRGDSKDLKHYLFFAYKVTFSLEAFAALVIMIDFIPRFG
                     WKNGIFNSIFLAVSAFCNAGFDNLGSSSLKDFMLNPTLNVIITFLIISGGLGFAVWVD
                     LGVAFKKYFFERPHCYGATFRKLSNQSRLVLQTTAVILFLGTFLTWFLEKDNSKTIAN
                     FSLHQQLMVSFFQTVTMRTAGFATISYNDTLAPTNILYMIQMVIGGAPGGTAGGIKVT
                     TAAITFLLFKAELSGQSEVTFRNRIIANKTIKQTMTVLIFFFAVLMIGFILLLSVEPH
                     IAPIPLLFESISAIATVGVSMDLTPQLSTAGRLIVIVLMFVGRVGPITVLISLIQRKE
                     KTIQYATTDILVG"
     gene            complement(17029..17742)
                     /gene="rsmG"
                     /locus_tag="VHC05_001396"
     CDS             complement(17029..17742)
                     /gene="rsmG"
                     /locus_tag="VHC05_001396"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="HEQ5402696.1"
                     /translation="MTPQDFYRTLEEDGFSLASKQKEQFDTYFKLLVEWNTKINLTAI
                     TEKNEVYLKHFYDSIAPILQGFLANEPIKLLDIGAGAGFPSLPMKILFPNLEVTIIDS
                     LNKRISFLTLLAQELGLENVHFFHGRAEDFGQDKAFRGQFDVVTARAVARMQVLSELT
                     IPFLKIGGKLIALKAQAADQELEEAKNALCLLFGKVIKNHSYQLPNGDSRFITIVEKK
                     KETPNKYPRKAGLPNKKPL"
     gene            17892..18449
                     /locus_tag="VHC05_001397"
     CDS             17892..18449
                     /locus_tag="VHC05_001397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LemA family protein"
                     /protein_id="HEQ5402697.1"
                     /translation="MPTVLIILVVLGVLALWLMISYNSLVKSRMHTKEAWSQIDVQLK
                     RRNDLIPNLIETVKGYASYEQKTFEKITDLRARVANASTPQETMAASNELSKQVTSLF
                     AVAENYPDLKANENFLKLQEELTNTENKISYSRQLYNSTTSNYNLQLESFPSNIAGKL
                     FGFKPSEFLQTPEAEKEVPKVEFNF"
     gene            18496..19392
                     /gene="htpX"
                     /locus_tag="VHC05_001398"
     CDS             18496..19392
                     /gene="htpX"
                     /locus_tag="VHC05_001398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease HtpX"
                     /protein_id="HEQ5402698.1"
                     /translation="MLYQQISQNKQRTVVLLVVFFALLALIGASAGYLLLDNYAMGLV
                     LALVIGVIYATSMIFQSTSLVMSMNNAREVTEKEAPGFFHIVEDMAMVAQIPMPRVFI
                     IEDPSLNAFATGSSPQNAAVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAV
                     ALASAVTVISSIGGRMLWYGGGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQ
                     LAISRQREYLADASSVELTRNPQGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKR
                     SFSSLFSTHPPIEERIERLKNM"
BASE COUNT         6336 a         3181 c         4006 g         6015 t
ORIGIN      
        1 aaaaaagtgt aatcattttt tgatttacag ttattatcat gtgttatctg gcgactgtcc
       61 tgtttacaag taagttcaca agtatgggat aaaatagtat aaactatagt aaatactgaa
      121 tagtcataga aaaatatcgg cataggtcag aagagctgat atgtttaaca ctttttgcgg
      181 atatctactg tatttaaatg tatttgatat ccttgtcaag gatatacgtc taaacaagtt
      241 caaaacgaaa ttatttgtga ttatcttatc aggagttgac tcttgataag atttttgtat
      301 attagtactg tggcacgttt agatagtttg gcagtgaatt tatagagtgt caaacaacga
      361 gtgttttgtg ttacactaac cattagaaga gtctattgtt gagcatatca aggtgttacc
      421 ttttcgagtt gaggtatcat atctagtata tttaactatg gttttaaatg ctatttcaaa
      481 aaaaatatga taaaatagaa agtactaatt attttggaga tgacatgagt atcgatgatt
      541 ataggccgac ctatatggta gaggctattt atgatttaag agcaaatgat ttgttgcgtc
      601 atggtattac ggctgtttta gtggatttag ataatacctt aattgcatgg aataatcctg
      661 atggcacacc agaggttcgc gcttggcttg atgaaatgac tatcgcggat attagcgtgg
      721 ttgttgtttc aaataataaa cattctcgtg ttgagcgtgc cgtttcacgc tttggagttg
      781 actttattag ccgggctttg aagccatttg cttatggtat tgaaaaagcc attgctcgtt
      841 atggatttga tcgcaacgag gttatcatgg ttggagatca gctaatgact gatatcagag
      901 ctagtcatag agctggaata aaatcagttt tagtcaaacc acttgttgct tctgatgctt
      961 ggaatactaa aattaaccgc tggcgtgaac gccgtgtgat ggcaaaatta gaagagaaat
     1021 atggtaaatt atcatatcaa aaaggaattt aatggaagaa ttattttgta taggctgtgg
     1081 tatccagatt caaactgaag acaaagaaaa agctggtttt acgccagctg ctgctttgaa
     1141 aaagggtatg gaaacaggag aactctattg tcagcgctgc tttagattga ggcattataa
     1201 tgaaattaca gatgtccata ttaccgatga tgaattttta agacttcttc acgaagtggg
     1261 tgatagtgat gctcttgtgg ttaatgtgat tgatattttt gactttaatg gttctattat
     1321 tccaggtcta tctcgcttta tttctggtaa tgatgtctta ctggttggga ataaaaaaga
     1381 tattttgcca aagtctgtta aggatggtaa agttactcaa tggttgacgg aacgtgcaca
     1441 cgaagaaggt cttcgccctt tagacgttat gttaacgagc gctcaaaata aatatgcgat
     1501 taaagacttg attgagcgta tcaatgagtt acgtaatggt cgagatgttt atgttgtggg
     1561 ggtcactaat gttggtaaat cgaccttaat taatgccatt attcaagaaa ttacagggga
     1621 taaagatgtg attacgacgt cccgcttccc tggaacgacc cttgataaaa ttgaaatccc
     1681 actggatgac ggtagcttca tatttgatac gccaggtatt attcatcgtc atcaaatggc
     1741 tcattattta tcccctaaag agctaaaaat agtgagtcct aagaaggaaa tcaagcctaa
     1801 gacgtatcaa ttaaactcag aacaaactct ctttttaggt ggtttgtctc gctttgactt
     1861 tatcaatggg gagcgtcaag ggtttacagc tttttttgac aatcaactag aattacatcg
     1921 tacaaaatta gatggagcag atgcttttta tgataagcat gttggaactt tgttaactcc
     1981 cccaggtaag aaagagttga cagcatttcc taaattagtt cgtcatgaat ttacaattga
     2041 tcagaaaatg gatattgttt tttctggtct aggatggatt cgtgttaatg gtcaaaaaga
     2101 ctcaaaagcg atagttgctg catgggctcc tgaaggggtc gctgtcattg ttcgtaaagc
     2161 gattatttaa aaataaaaaa gaagttggaa aaaaatgctt acaagtaaac aaagagcttt
     2221 cttaaaatct gaggctcata gcttaaaacc gattgtacaa attggcaaaa atggattaaa
     2281 tgaccacatt aagactagta ttcgtcaagc tttggatgct agagaattga taaaggtcac
     2341 tttgttgcaa aatactgatg aagatattca tgaagtagca gagattttag aagaagaaat
     2401 tgggtgtgat acggttttga aaattggtcg tatcttgatt ctctataagg tttctgctaa
     2461 gaaagaaaac cgcaagttgt cccctaaagt taaagcaatt tagtcctttt atttgtatag
     2521 gggctggtct tatgagacga ggactattgt cgcgagaatt ttggagaaag tatggcatta
     2581 gaattgttga cgccttttac gaaggtggaa ttagaggaag aaaaaaaaga aagcaaccgc
     2641 aaacagattg ggattttagg agggaatttt aatcctattc acaatgcaca ccttgtggtt
     2701 gcagatcaag ttcgccagca attaggatta gatcaggtgc tgttgatgcc tgaatgtaaa
     2761 ccaccgcatg tggatgccaa agagactatt gatgagaagc atcgtcttcg catgttggaa
     2821 ttggctattg aagatgttga agggctagct attgaaacct gtgaacttga acgtcaggga
     2881 atcagctata cctatgatac gatgctttat ttgactgagc agcatcctga tgttgatttt
     2941 tattttatca tcggagctga tatggttgat tatttgccaa agtggcaccg tattgatgaa
     3001 ttggtcaaac tcgttcaatt tgttggggtt caacgtccaa aatataaagc tggaacctct
     3061 tacccagtca tttgggtaga tctacctttg atggatattt cttctagtat gattagagat
     3121 tttattaaaa aaggtcgtca gcccaattat ctcttaccta agcgggtttt agactacatt
     3181 actcaagaag gtttgtatca atgacatatg aagattatct tccttatagc aggaccgaac
     3241 tgttagcaaa aattgcagag cagatgagcc ctaaacggtt taaacatgta cttggcgtgg
     3301 aaaaggcagc cttgtccttg gcagagtgtt atggttgtaa cccagacaaa gcagggttag
     3361 cagctctttt acatgattat gccaaggaat gctctgacca ggttttttta gacttgattg
     3421 acaagtacca attatctcca gaattagcta aatggaataa taatgtctgg catggtatgg
     3481 ttggtattta taagattcaa gaagacctag ggttgcaaga taaagagatt ttgcgagcta
     3541 ttgaaattca caccgttggt gctgctgaga tgaccttgct ggataaggtc ttatacgttg
     3601 ctgattatat tgaagaaggt cgcatctttc ctttggttga tgacgctaga aaaatcgcgc
     3661 agcttgattt ggataaggct gttgcctatg aaacagtgaa cactgtcgcc tatttagcct
     3721 caaaagcgca gcctattttt ccacagacct tagatacata taatgcgttt tgcagttatt
     3781 taaaggagaa gtaattgaaa aaggcattga taacttggta atgataggaa tgctcactaa
     3841 ttattgtatg gatatgacag tgagggttgc ttttgaactg ggctatgagg tgtcagtgat
     3901 agaacatggt tcaacaactt ttgacgatga ggacattcag gcttcactcc tgattgacta
     3961 ccatgagagt ttgtgggatg gtaattttgc tcgagtagag cctttagatg tgattttaaa
     4021 tgaggaataa aatgaaaaaa gaagaattat tagagattgt ggttaaggct gcagatgaaa
     4081 agcgggctga agatatgtta gccctcgatt tagaaggttt aaccagtttg actgattatt
     4141 ttgtgattgc gagtgcaaca aatagtcgtc aattagaggc tattgcggat aatattcggg
     4201 aaaaggtaaa agaggctggt ggagatgcta gccatattga aggtgatagt caagcaggct
     4261 gggtcttgct tgatttgacc gatgtggtgg tacatatttt ttctgaggat gagcgttacc
     4321 actataatct tgaaaaattg tggcatgaag cgcctgctgt ggctctagat gcctatttag
     4381 cttaacgtta caaagagacc ttgtcaatac gacagggttt ttgaggatga taatggaaca
     4441 taattatgaa aaatttgcat cagtttatga tgccgtgatg gacgactctt tatatgactt
     4501 gtggacagat ttttcacttc gacatttacc aaagtctaag ggtcgaaatc gtttgttaga
     4561 gttggcctgt ggaactggta ttcagtcagt tcgttttgct caagcaggtt ttgacgtgac
     4621 tggtttagac ttaagtcaag acatgttgac tattgctgaa aaacgggctc agtctgctaa
     4681 aaagaaaatt gattttattc aaggcaatat gctggattta tcacaggtgg ggcagtttga
     4741 ttttgtcact tgctattcgg attccatttg ttatatgcaa gatgagcctg aggtaggtga
     4801 tgtttttaaa gaagtctatg atgttttagc ggatgatggc atctttattt ttgatgtaca
     4861 ttcaacctat caaacggatg agtgtttccc tggttattcc tatcatgaga atgcagatga
     4921 ttttgcaatg gtttgggata cctatgctga cgaggctcct cactctgttg ttcatgaact
     4981 cactttcttt atccaagaag acgatggacg tttttctcgc tttgatgaag tgcatgagga
     5041 acgaacgtat gagttattga cttatgatat tttgttggaa caagcagggt tcaagtcatt
     5101 caaggtctat gcggattttg aggataagga gccgactgag actagcaagc gttggttttt
     5161 tgtggcatat aaatagaaga aaaaagtagc ctttttagct ataggattta atgaattaac
     5221 ttgaatgtta cttatatgaa aagagtttat taggcattaa atgctattat caaagcttag
     5281 aagtattgga gacattacga ttgacactat gtctgaaggt tgctaccaac tttaaagaaa
     5341 gcattttcta ttatacgttg tgcttaagca tttgatttaa ctcttattag ccctataaaa
     5401 gattatttag tacaatttga ggagattcta tgactgttac cggaattata gctgagttta
     5461 atccgtttca caatggacac aaatatttgc tagaaacagc agagggacta aaaattattg
     5521 ctatgtcagg aaattttatg caaagaggag agcctgctct tattgataaa tggattcgat
     5581 cagagatggc tcttaaaaat ggtgcggata ttgttgtgga attgcccttt ttcgtttcag
     5641 ttcaatcagc agactatttt gctcaaggag ctattgatat tctttgtcaa ttaggaattc
     5701 agcaattagc atttgggaca gagaatgtga ttgattatca aaaactgatt aaggtctatg
     5761 agaaaaaatc aaagcaaatg actgcctatt tatcgacgct tgaagataca cttagctatc
     5821 cacaaaaaac acaaaaaatg tgggaaatct ttgctggagt taaattttca gggcaaacgc
     5881 caaatcatat tttggggtta agttatgcaa aggctagcgc tggaaagcat atacaactat
     5941 gtcctatcaa gcgtcaaggg gctgcctacc attcgaaaga caaaaatcat ctgctagctt
     6001 ctgcaagtgc cattagacaa cacctgaatg attgggattt cataagtcat tcagtaccaa
     6061 atgcaggttt acttataaac aatccccata tgtcatggga ccattatttt tcattcttaa
     6121 aatatcaaat tctgaaccat tctgatttaa ctagtatttt tcaggtcaat gatgaattgg
     6181 caagtcgtat taaaaaagcg ataaaagtta gtcaaaatat tgaccaccta gttgacactg
     6241 ttgctaccaa acgctataca aaagctcgtg taagacgtat tttaatctac attttggtta
     6301 atgctaagga acctacttta cctaagggaa ttcatattct agggtttacc tcaaaaggac
     6361 aagcacattt aaaaaaatta aaaaaaagta ggcctctgat tactagaatt ggagcagaaa
     6421 cttgggatga gatgacacaa aaagcagaca gcatctatca acttgggcat caggatatcc
     6481 cagaacaaag ttttggaaga atacctatta taataaaaaa agagaggctc aattaaactc
     6541 taattgagtt tttttggggg cttgactcta acattacgtt gatggtttat acttcagtta
     6601 atccaatgag gaaattttat aacaataatt aaaaaagtca gtcaaaagat atgctttcga
     6661 agaacaggct aacgttttta caagattata tcagtaatca ttttgacaat tgtagtaatg
     6721 gaatgttgcc aaaatttaga acgttgtgtg ttatgaatga caagatttta aaggaatact
     6781 aattaaacgg gaggtcgtga accggaagct gttgtcactc aagcgctaaa atctgtctgt
     6841 aacataatat tgatgtatgg gaacgcaatt atttggtttt tattgtgatg cttaaaacga
     6901 ttttatattt ctattttacc aaagcttttc aaagtgctat aataagggag ttagagtcaa
     6961 tattagtaac gttaatgttg acaatattca ataaaatact attaaaagga gacaaaaatg
     7021 ggacgtaaat gggcaaatat tgttgctaaa aaaactgcta aagatggagc aacatcaaag
     7081 atctatgcca aatttggtgt tgaaatttat gtggctgcca aacaaggcga gccagatcca
     7141 gagttaaata cagctcttaa atttgtcatt gatcgtgcaa agcaagcaca agtgccaaag
     7201 catgttattg ataaagcgat tgataaagct aaaggaaaca cagatgaaac tttcgtagag
     7261 ggacgctatg aaggttttgg tccaaatggt tcaatgatta ttgtggatac tttgacatca
     7321 aatgttaacc gtacagcggc aaatgtacgt acggcttacg gtaagaacgg tggcaatatg
     7381 ggagcttcag gatctgtatc ctacttattt gataaaaaag gggtcatcgt ttttgctggt
     7441 gatgatgctg acagtgtctt tgagcaatta cttgaagcgg atgtagacgt agatgatgtt
     7501 gaagcagaag agggaacaat aacagtttac actgccccaa cagatcttca taaaggtatc
     7561 caagcacttc gcgataatgg tgtagaagaa ttccaagtta ctgaacttga aatgattcct
     7621 caatcagaag tagtattgga aggtgatgac cttgaaactt ttgaaaagct tattgatgca
     7681 ctcgaatcag atgatgatgt tcaaaaagtg tatcataatg tagcagattt ttaaattgac
     7741 atagaataat aaaaagagtt gaaatctatt tcagctcttt ttaagtgatg cttttataag
     7801 taagtaccag gtaacatagt cgttgttaga agataatgaa caatagtaaa tcagtatcaa
     7861 cttgatagga atcaattatt agtgaactct aattaaaaat ggtaaactag acacaagaac
     7921 aaaaaggaga gataggatga ttaaaaaaca gtatttagga agggcaacaa ttgccctagc
     7981 atcgaccctt gtgctagcag cttgtgggtc atcaaaaaca gctgagtcag gaaatcaggg
     8041 gagttctaaa gaagtcttat ttgcaacggt tggaacaaca gctccttttt cttatgaaaa
     8101 aggtggtcaa ctaactggct acgatatcga ggtggctaaa gcagtcttta aaggatcgga
     8161 tgattacaag gtgtccttta aaaaaacaga atggtcttct atctttacag gtttggactc
     8221 aggaaaatac caaatgggtg gtaacaacat ttcctttacc aaagagcgtt cagctaagta
     8281 ccttttttct tatccaatcg gatcaacacc ttctgtttta gttgttccaa aagacagtga
     8341 tatcaagagc tttgatgata tccaagggca tacgacacaa gttgttcaag ggactacaag
     8401 tgttgcacag ttagaagact ttaataagaa acacagtgac aacccggtta ctctaaaatt
     8461 caccaatgag aacattactc aaatgttaac caatttgagt gaaggcaagg cagatttcaa
     8521 gatttttgac gctccaacgg ttaacgccat tattaaaaat caagggttag ataatctcaa
     8581 aacaattgaa ctcacctcaa cagagcaacc atttatttat tttatcttta gtcaagatca
     8641 agagaaattg caaagctttg ttaacaagcg tattaaagag ttgactgctg acggaactct
     8701 tagcaagctt accaaagagc accttggcgg tgattacgtg ccatcagata aagagttgaa
     8761 acttcctaca gctaactaaa ccatctatta accagttatt catctagaag actggttttt
     8821 ctgatcggaa acaatattat agtttatgag gttatgttat aaaaattgca aatagcctta
     8881 atcaaaatga gatgttaaag tgctttttga gaagtgaata ttgtaagaag tatgctttgg
     8941 gttttagtcc tcaaatacca agttttttgt tgactaaaca aataaggatg gttagcatag
     9001 catatagttt aaaactatgg tatatgctag ccattatcaa tttgaaaact atatctaatt
     9061 aagatacaat aatgatcgta aacaaaatga atcgagggta acgctatgtc ttttaaaaaa
     9121 tggattggaa tagtcggaat cgctttggca tcaactgtat tggttgcttg ttctgaaaaa
     9181 caagatgata aaaacactct aactattggg gtgatgacaa aaacagaatc tgatcaagcg
     9241 agatgggata aagttgaaga attattaaaa aaagacaata tcactttgaa gtacaaagaa
     9301 tttacagatt actcgcaacc taataaggca gttgctaatg gtgaagtcga tattaatgcc
     9361 ttccaacact ataatttctt aaataactgg aataaggaaa ataaggaaca tttggtggcc
     9421 attgctgata cctatatcag cccaattaac cttttctctg gaaccagtca agatgggaat
     9481 gctaaataca aatcagtagc tgatctgcca aatggtgctc aaattgcagt accaaatgat
     9541 gcgaccaatg aaagccgtgc cctctatgtg ctgcaatcag ctggcctcat taaattgaat
     9601 gtgtctggtg atcaattagc aaccattgcc aatatctcag agaacaaaaa gaaattagat
     9661 atcaaggaat tagatgctag ccaaacggca cgtgctttag tatctgctga tgcagctgtt
     9721 gtcaataata gttacgctgt tcctgcaaaa attgactaca aaacctctct tttcaaagaa
     9781 aaagcagatg acaattcaaa acaatggatt aacattattg caggtcaaaa agattgggaa
     9841 aaatcagaga aggctgatgc tattaaaaaa ctcatcaagg cctaccaaac tgatgaggtg
     9901 aagaaagtcg tggaaaaaac ttcaaatggt atagatgtat ccgtatggta aattttagcc
     9961 attgttataa caagagtgtg gtcgtgttta aaacacatgc tttcttgcat gcttgaggaa
    10021 gagtttacga ttaatttacc tttagaaagc tatttaagac cttttccctt ttaggattta
    10081 gaaaccttgg gaagactatt gcatgttatc ttaatagtca tgattatgca ggcgatgaaa
    10141 acattgctat cgtagattac tgtcgccata tcgtactaat agaggagtta ttaaaatctt
    10201 atgaatgaag cgattattca attagatcat attgatatta cctttcatca aaaaaaacgg
    10261 gttattgagg ccgttaaaga tgtcacggtt catattaatc agggagatat ttatggcatt
    10321 gttgggtatt caggtgctgg gaagtcaacc cttgtgcgtg tgattaatct tctacaagca
    10381 ccaacaaatg ggaaaatcac cgtagatgga gacgtaacct ttgaccaagg gaaaattcaa
    10441 ttgtcagctg aggcccttcg tcaaaaacga cgtgatattg gcatgatctt ccaacatttc
    10501 aatttgatgg cccaaaaaac agccaaagaa aatgtagcat ttgcgctccg ccattcgtcg
    10561 ttaagtaaga ctgagaaaga acagaaagtt atcgaactgc tagaacttgt gggtttatca
    10621 gagagagcag ataactaccc tgcccagtta tcgggtgggc aaaaacaacg agtggctatt
    10681 gcgcgtgctt tagccaatga tcctaaaatt ttaatttcag atgaggccac gtcagcacta
    10741 gatccaaaga ccaccaaaca aatcttggcg ctcttgcaag aattaaaccg caaacttggc
    10801 cttaccattg ttatgattac tcatgaaatg caaattgtta aggatatttg taatcgtgtt
    10861 gctgttatgc aaaatggtgt tttgattgaa gaaggtcctg tccttgatat cttttcaaat
    10921 ccaaaagaag ccttgacaca ggaatttatc acaacagcta cagggattga tgaggcttta
    10981 gaaaaaatta accaacaaga cattgttaaa catttgcctg caaatgccct tctagctcag
    11041 ttgaaatatg caggaacttc tacggatgag cctctactta atagcattta ccgtcagttt
    11101 gaagtgacag ctaatatttt gtatggcaat attgagattt tagatcatat tccagttggt
    11161 gacatgattg ttgtcttgga agggcaagct gaaaatattc ttgcggctga gaaagccttg
    11221 catgaagctg gtgttgatgt tagtatttta aagagaggag cctagatgtc acagttaatt
    11281 caaacttatt tgccaaatgt ttatgaactc ggatggtctg gagatgctgg ttggggctta
    11341 gcgatttgga atactttata catgaccatt gtgcctttta ttgttggggg tgctattggt
    11401 ctcttattag gcttgttatt agttttaaca ggaccggacg gtgttattga aaacaaaacg
    11461 atttgttggg tcattgataa agttacctct atttttagag ccattccttt tgttattttg
    11521 attgctattt tagctagctt tacctatttg cttttaagaa caactttagg agcaacagcg
    11581 gccttggtac ctttaacctt tgcgactttt cctttttatg cccgtcaggt ccaagttgtt
    11641 ttttcagaat tagacaaggg tgttattgaa gcagcgcaag cttcaggtgc tactttctgg
    11701 gatattgtca aagtgtatct cagtgaaggt ttaccagatc ttattcgtgt ttctacagtc
    11761 accttaattt ctttagttgg ggaaactgcc atggcaggag ctatcggtgc tggaggatta
    11821 ggaaatgtag cgatttctta tggttataat cgttttaaca atgatgtgac ttgggtagcg
    11881 actattatta ttcttttaat tatttttgct atccaattta ttggtgatag cttgaccaga
    11941 cggtttagtc ataaataaac gaaacaacac cctaagtaaa aacttagggt gttgttgttt
    12001 agatgatgtc attagctttt cttcgtttta cttagtataa gccctattaa aaaaccaata
    12061 gcagcaaata taatccatcc cattgagaat tgccctagtg gaacagtttt ttggaaaaaa
    12121 gttacaacgt cttctggtaa atgaaataat ccagtcattt gtgatagtgt taggagtgca
    12181 tcaaatatgg caggaataaa ggttagacca attgtagttc gatagacaat aggatcatta
    12241 ttgaagcatt tttgtgccaa aacaaggaaa attaaatcaa ctgttaatgg gtataaaagg
    12301 aataaaacag gagctgacca gttgataatg actgataagc caccaaaata aaagaaagct
    12361 gatagtaaag taaagatagt tgcccaagca atatgagata aagcaggcac taatttatgg
    12421 aagtattcag cgcttgacgt gattaagcct gttgaagtgg ttagacaggc caggaaaatc
    12481 acaacagcta gaaatgcttg tccgatgcca cctaggtaaa aacgagaagc atgacttaag
    12541 atttgaccgc cattaactgg attaccatga agggtaaagc tgccatcaat aaaaggaaat
    12601 aatgattgtg atgttgctcc aatacgaccg acaaagatat agacaagtgc taatagcaaa
    12661 atggcaatag ccccagaaat aagtgttatt ttggtcactt ctttgtccgt cttagcgcca
    12721 aattgtttgg tagcctcaat gactaaaata gcaaaaacaa gagaagctag tgcatccata
    12781 gtgccataac cttgaattaa tcctgctata aaaggaaaat ctttaaaggc attattaaca
    12841 ccgaccccag cgttaaaagc atcaccgtaa tttccagcag gatggacaaa ggacgcgata
    12901 accaaaatag aaataacaac taacaacgtt ggcgttaaaa attttccgat attttcagct
    12961 agcttactag gtttgatagc aaggaagtag gacagaccaa aaaatagtat agcataaata
    13021 gctttattgg ttgtattatc tcctaagata ggagcgatac cgactgaaaa agaagtggcc
    13081 cctgttcttg gaatagcaaa aaatggacca atagataaat acaaaatgga agaatagaag
    13141 attgcatacc atttagagat ggggcgtgcc aaactttcaa catcgcctga tccagattta
    13201 gcaacagcaa tgacaccgag taaaggcaag gagacaccag ttaaacaaaa accaatgata
    13261 gaccatagaa tctgatgacc tgagtagatg cctaaaaaag ctgggtaaat gaggtttgct
    13321 gctccaaaaa atagcgcaaa tagcatgaat ccaatgacga tatatacatt tttttgtttc
    13381 atttataaat agtctttcta ttgatactaa tccgaatatt ctaacaattt taattatatt
    13441 atgtgtcaaa ataacaacaa aggttattat atctaagatt acttcgatag tcaatagaaa
    13501 ttgactgaaa attcttagca caaaaaatgg ttaagatatg tagctcattc gatttgacga
    13561 atagatagaa ttatattatt ataaaaaaca tgtaacttta gtaaggatgt aacgtatgaa
    13621 aaaaatatat gatttatggg ttagggttag tctaatcaaa aaaataggta tcggtgttgt
    13681 aataggagtc atgttgggca ttttggctcc tgatcttaca ggttttagta ttttaggaaa
    13741 gttatttgtt ggtggtttaa aggctatcgc acctttgctt gtatttgctt tggtttccca
    13801 agccatctcc catcagaaaa aagggagaca gactaatatg acattaatca tttttctgta
    13861 tttatttggt acctttgcgt cagctttagt agcagtactg acagcttatc tattcccttt
    13921 gacgttagtg ttaaatacac ctgtaaatac agaattatca ccacctcaag gtgttgctga
    13981 agtttttcag tcacttctat taaaattagt ggataatccg atcaatgctt tagctactgc
    14041 caattatatt ggtgtgctat catgggcaat tatttttgga ctagcattaa aggctgcaag
    14101 tcaagaaaca aagcatctta taaaaacagc ggcagaagtt acttcacaaa tagttgtttg
    14161 gatcatcaat ctggcaccta ttgggattat gagtctggtg ttcactacga tttctgaaaa
    14221 cggtgttgga atcttatctg attatgcttt tttgatacta gttttagtag gaacaatggt
    14281 ttttgtcgcc ttagtggtta atccacttat tgcggttttg attacacgac aaaatcctta
    14341 tccccttgtc ttaagatgtt tacgtgagtc aggtcttaca gcatttttca cacgaagttc
    14401 tgcagccaat attccagtca atatgcagtt atgccaaaaa attggattga gtaaagatac
    14461 ttattcagtg tcaattccac ttggagcaac tattaatatg ggtggggcag caattaccat
    14521 caatgtccta acgcttgctg ctgtacacac ttttggtatt cctattgatt ttctaacagc
    14581 cctcttactt agcgttgttg ctgctgtctc tgcttgtggt gcttctggtg ttgctggggg
    14641 atcgttgtta cttattcctg tagcatgtag tttgtttggc atttcaaatg atcttgcgat
    14701 gcaggtggtt ggtgttggtt ttattgttgg tgttatccag gattcttgtg agacagcctt
    14761 aaattcgtca accgatgttc tttttacagc tattgctgaa aatgcttttt ggaaacgtaa
    14821 aaaagcctag ctaggtttaa cataataaaa aacatccttg gaaaacgcca aggatgtttt
    14881 tttattattt aagatagcca agataatcaa atttttcaaa ggtgtggtca ttagcgatgg
    14941 ccacaatgat agtattcggt tctaaaggtt caaaaggttt gacattagta tctaaggttt
    15001 tcacttcctt ttgacgcatt ccaataatgt tcaattcata cttacgacga acatctaact
    15061 ctgaaagaga ctgtccttcc caacttttag gaataataaa ctcaatcatg gaaatgccat
    15121 gttcgaggta gatgatgctt tcgatatgac gtcttaacag atttgaagct acacgttttc
    15181 cagaatcacg ttcaggggtg atgactttag ttgctccgat gccatataga acttcttcaa
    15241 aaattttatt tttagccttg gcaataatgg ttggaacacc gagtttttta cagtgcatga
    15301 ctgcaagaac agaagattcc aagttattcc ctgaagcgat aacgacagta tcacaatgtt
    15361 caatccctac agctaataga aattctttgt cagtaatatc tccaacagcg gctttagtga
    15421 ccaagtcggc cacctcttta acatgacttt ctctgatatc aatagcaata acgtcttgat
    15481 caaaattact taattctcta gcaacagtac ggccaaaaat accaaggcca agaacgccga
    15541 cagttttacg ttttaacatg ttttctcctt aacccactaa aatatcagta gtggcatatt
    15601 gaatggtttt ttcttttcgt tgaatcagac tgatgaggac agtaattggg ccaacgcggc
    15661 cgacgaacat caagacaatg acaataagac gtccagcagt agacaattgt ggtgtcaaat
    15721 ccatagatac cccaactgtc gcgatggcag aaatagattc aaataagagt ggtataggag
    15781 cgatatgagg ctccacgcta agtaataaaa taaaacctat cataagaact gcaaaaaaga
    15841 agataagaac tgtcatggtc tgcttaattg tcttatttgc gataattcgg ttacgaaagg
    15901 taacttctga ttgccctgaa agttccgctt taaagagtaa gaaagtaatg gcagcagtcg
    15961 tcactttaat cccaccagct gttccaccag gagcaccacc aataaccatt tgaatcatat
    16021 aaagaatgtt agttggtgct agggtatcgt tataagagat tgttgcaaag ccagctgttc
    16081 tcatagtgac tgtttgaaaa aatgaaacca taagttgctg atgtaaacta aaattggcaa
    16141 tggttttgct gttatctttt tctaaaaacc aggttaagaa ggttccaaga aaaagaataa
    16201 cagctgtggt ttgtagtact agacgagact gattggataa tttacgaaaa gttgccccat
    16261 aacaatgagg tctttcaaaa aagtattttt taaaagctac tcctaaatca acccaaaccg
    16321 caaaaccaag tccaccagag ataatcaaga acgtaatgat aacatttaat gtaggattta
    16381 acataaagtc ttttaaacta gaagatccta aattgtcaaa accagcgtta caaaatgccg
    16441 acacagctag aaaaatacta ttgaagatac catttttcca cccgaagcgg gggataaagt
    16501 caatcatgat aactagcgca gcaaaggctt ctagactaaa ggttacttta taagcaaaaa
    16561 aaaggtagtg ctttaaatct ttgctatcac ctcgatttaa cgctgattgg agcaaggttt
    16621 gatcgctcaa tcgcattttt cgcttgaggg caaaagtact cacagctatt aacgtcacca
    16681 agccaagacc accaatctgc attagtgcca tagcaatggt ttgtccgata ccgttataca
    16741 cttcagcgac gggaacaaca gaaagtccag tcacacaaac catggaaacc acattaaaga
    16801 aatgatcaag atagacggta ttaggaccat tttgataatg ggtaaagggc atggataaca
    16861 agagagtccc aatcagaatc acaatggcaa aactaaatgt taaacgctgt gtgactgaaa
    16921 gagatttgat aaaagagcgt ttcatgtttc ctccagacat aatatctcct actataataa
    16981 caaaaataag ttaaaaaagc taagtttcat cttagccttt ggtactattt atagaggttt
    17041 tttgttaggc aagccagctt ttcttggata cttgttaggt gtttcctttt tcttttcaac
    17101 aatggtgatg aagcgagaat ctccatttgg caattggtag ctatggtttt taatgacttt
    17161 accaaaaaga agacaaagag cattcttagc ttcttctaac tcttggtcag cagcttgtgc
    17221 ctttaaggcg attaattttc ctccaatttt taaaaagggg atggttaatt cagatagaac
    17281 ctgcatccga gcaaccgctc tggcagtaac gacatcaaat tgacctcgaa aggccttgtc
    17341 ctgtccgaaa tcttctgctc taccatgaaa aaaatggaca ttttccaagc ccaattcctg
    17401 agcaaggagt gtcagaaaag aaatccgctt attaagagaa tcaataatgg taacctcaag
    17461 gtttgggaaa agaattttca tgggtaggct aggaaaacca gctccagctc caatgtccaa
    17521 taatttgatt ggttcattag ctaaaaagcc ctgtaaaata ggagcgatgg aatcataaaa
    17581 atgcttgagg taaacttcat ttttttctgt aatagctgtt aaattaattt tagtgttcca
    17641 ttccactagt aatttgaagt aggtgtcaaa ttgctctttt tgcttcgatg ctaaggaaaa
    17701 accatcttcc tctagtgttc ggtaaaagtc ttggggtgtc atttgtatcc tctgtttttg
    17761 atagttgtta ccattttatc ataaaatagc ccataacaaa atccaataaa tcatcagaaa
    17821 taacacctca ttacttgcta ttagcctaga aattgctata attgagacac aaagattaaa
    17881 ggagacccac tatgccaaca gttttgatta tcttagtcgt tttaggagtg cttgcgctat
    17941 ggttaatgat tagttacaat agcctggtta aatctcggat gcacacaaaa gaagcttgga
    18001 gtcagattga tgtgcaatta aagcgtcgta atgacttgat tccaaatctt attgaaaccg
    18061 taaagggata tgctagctac gagcaaaaga catttgaaaa aatcactgat ttgcgtgcgc
    18121 gtgttgcgaa tgcctcaact cctcaagaaa ccatggcggc ttctaacgaa ttgagtaaac
    18181 aagtgaccag tttgtttgcc gttgctgaaa attacccaga cttaaaagct aacgaaaact
    18241 tcttgaaatt acaagaagag ttgaccaata cggaaaataa aatctcatat tctcgtcaac
    18301 tctataattc aacaacgtct aattacaacc ttcaattaga atctttccca agcaatatcg
    18361 ctggtaaatt atttggtttt aaaccaagtg aattcttaca aacaccagaa gctgaaaaag
    18421 aagttccaaa agttgaattt aacttttaaa tatgaaatta tcatctagta ggcaatcata
    18481 agagaaagga gaattatgct ttatcaacag atttcacaaa ataagcaacg aacagttgtt
    18541 ttattagttg ttttcttcgc tctcttagca cttattggag cgtcagcagg ctatctgctg
    18601 ttagataatt atgccatggg cttggttctt gctcttgtca ttggggtgat ttatgctacc
    18661 agtatgattt ttcaatccac cagtcttgta atgagtatga acaatgctag agaagttaca
    18721 gaaaaagagg ctccaggctt cttccatatt gtcgaggata tggctatggt agctcagatt
    18781 ccgatgccga gagtttttat tattgaagat ccttctttaa atgcttttgc gacaggatct
    18841 agccctcaaa atgctgctgt tgcagcaacg acaggtttac ttgaagtcat gaatcgtgaa
    18901 gaacttgaag gtgttatcgg ccatgaaatt agccacatcc gaaattatga tatccgtatt
    18961 tcgactattg ctgtagcttt ggcgagtgct gttaccgtta tttctagtat cggtgggcgt
    19021 atgctatggt atggtggcgg ttctcgcagg caaagagatg acggagatga tgatgtttta
    19081 agaatcatta cattactttt gtcgttatta tctttgcttt tagcgcccct agtagcaagt
    19141 ttgattcagt tggctatttc tcgtcaaaga gaatatctag ctgatgctag ttctgttgaa
    19201 ctaacaagaa atccccaagg tatgattaag gctcttgaaa aattgcagtt atctcagcca
    19261 atgaagcatc ctgttgatga tgctagtgcg gccttgtata ttaatgagcc tcgcaaaaaa
    19321 aggagcttca gttcattatt cagcacccat cctcctattg aggagaggat tgaaaggtta
    19381 aaaaacatgt gagcgtttgg ggtttttgct caagcctcac ttttttatgt ctttgggcag
    19441 ataatctaaa atggcaggaa ttatcaaaaa tatctgaaca aaaagaaaaa aatgagtgaa
    19501 acaatggtta aaaatagaat gatttaaatc ttaaaatt
//
LOCUS       DAUDWO010000039        18111 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.039, whole genome shotgun sequence.
ACCESSION   DAUDWO010000039 DAUDWO010000000
VERSION     DAUDWO010000039.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18111)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18111)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18111
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.039"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(<1..394)
                     /locus_tag="VHC05_001399"
     CDS             complement(<1..394)
                     /locus_tag="VHC05_001399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011529130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402699.1"
                     /translation="MLYLNTQTDSDYKEIIFGDIAKFVENMFYHYFSSILFRDLETVD
                     KRMYSFSDDDLISIQSSCLRLSKTFANFNIQRKNFLASDETEMDTFHKKDDIDITVGE
                     KSYNLARSFRTSTINELTVFNFEEMFDII"
     gene            complement(588..926)
                     /gene="cadX"
                     /locus_tag="VHC05_001400"
     CDS             complement(588..926)
                     /gene="cadX"
                     /locus_tag="VHC05_001400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cd(II)/Zn(II)-sensing metalloregulatory
                     transcriptional regulator CadX"
                     /protein_id="HEQ5402700.1"
                     /translation="MKKDSICQVNVINQQNVTTATNYLEKEKVQKSLRILSKFTDNKQ
                     INIIFYLLTVEELCVCDIACLLNLSMASASHHLRKLANQNILDTRREGKIIYYFIKDE
                     EIRDFFNQLG"
     gene            complement(938..1552)
                     /locus_tag="VHC05_001401"
     CDS             complement(938..1552)
                     /locus_tag="VHC05_001401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CadD family cadmium resistance transporter"
                     /protein_id="HEQ5402701.1"
                     /translation="MIQNVVTSIILYSGTAVDLLIILMLFFAKRKSRKDIINIYLGQF
                     LGSVSLILLSLLFAFVLDYIPSKEILGLLGLIPIFLGLKVLLLGDSDGEAIAKEGLRK
                     DNKNLIFLVAMITFASCGADNIGVFVPYFTTLNLANLIVALLTFLVMIYLLVFSAQKL
                     AQVPSVGEILEKYSRWFIAVVYLGLGIYILIENNSFDMLWAVLG"
     gene            complement(1846..1995)
                     /gene="rpmG"
                     /locus_tag="VHC05_001402"
     CDS             complement(1846..1995)
                     /gene="rpmG"
                     /locus_tag="VHC05_001402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001265622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEQ5402702.1"
                     /translation="MRVNITLEHKESGERLYLTSKNKRNTPDRLQLKKYSPKLRKHVT
                     FTEVK"
     gene            complement(2011..2193)
                     /gene="rpmF"
                     /locus_tag="VHC05_001403"
     CDS             complement(2011..2193)
                     /gene="rpmF"
                     /locus_tag="VHC05_001403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L32"
                     /protein_id="HEQ5402703.1"
                     /translation="MAVPARHTSKAKKNKRRTHYKLTAPSVQFDETTGDYSRSHRVSL
                     KGYYKGRKIAKANEAK"
     gene            2413..3693
                     /locus_tag="VHC05_001404"
     CDS             2413..3693
                     /locus_tag="VHC05_001404"
                     /EC_number="6.1.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine--tRNA ligase"
                     /protein_id="HEQ5402704.1"
                     /translation="MKLQKPKGTQDILPGDAAKWQYVESVARDTFSQYNYGEIRTPMF
                     EHYEVISRSVGDTTDIVTKEMYDFYDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQK
                     PVKLYYIGSMFRYERPQAGRLREFHQIGVECFGAANPATDVETIAMAYHLFEKLGIKD
                     VTLHLNSLGSPESRAAYRQALIDYLTPMRDQLSKDSQRRLDENPLRVLDSKEKEDKLA
                     VEKAPSILDYLDEESQAHFEAVQDMLEALDIPYVIDTNMVRGLDYYNHTIFEFITSVE
                     GSDLTICAGGRYDSLVGYFGGPETPGFGFGLGLERLLMIIEKQGITLPIETEMDIYLA
                     VLGDGANSKALELVQAIRRQGFTAERDYLGRKIKAQFKSADTFKAKLVMTLGESEVEA
                     GKAVIKNNRSRQEVEVSFEDMMTNFENISEQLLS"
     gene            4031..5779
                     /gene="aspS"
                     /locus_tag="VHC05_001405"
     CDS             4031..5779
                     /gene="aspS"
                     /locus_tag="VHC05_001405"
                     /EC_number="6.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--tRNA ligase"
                     /protein_id="HEQ5402705.1"
                     /translation="MKRSMYAGRVREEHIGTTITLKGWVSRRRDLGGLIFIDLRDREG
                     VMQLVINPEEVSSDVMATAERLRSEYVIEVEGFVEARQQANDKLATGMVELKVSALTI
                     LNTAKTTPFEIKDDVEVSDDTRLRYRYLDLRRPEMLENFKLRAKVTHSIRNYLDDLEF
                     IDVETPMLTKSTPEGARDYLVPSRVSQGHFYALPQSPQITKQLLMNAGFDRYYQIVKC
                     FRDEDLRGDRQPEFTQVDLETSFLSEQEIQDIVEGMIAKVMKETKEIDVTLPFPRMSY
                     DIAMNSYGSDKPDTRFEMLLQDLTVTVKGIDFKVFSEAPAVKAIVVKGNADRYSRKDI
                     DKLTEFAKQFGAKGLAWVKVTDGQLAGPVAKFLIAIETELSSQLKLAENDLVLFVADT
                     LEVANNTLGALRNRIAKDLDMIDQSQFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPT
                     PESAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKEMQERMFKALGFTADEANDQ
                     FGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGKGNIREVIAFPKNNKASDPMTQAPSLV
                     SENQLEELSLQIESHD"
     gene            5772..6713
                     /locus_tag="VHC05_001406"
     CDS             5772..6713
                     /locus_tag="VHC05_001406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011185085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEQ5402706.1"
                     /translation="MIKKTTYRKKVKYVISRGAKKVGLLHALRSISREKYAEKISASL
                     LYGILSSIAVNFFFQPGHVYSSGATGLAQVFSALSHRLLGYDFPIAFAFYLINIPLLI
                     LAWYKIGHQFTIFTFITVSMSSFFIQIMPQVTLTTDPLINAIFGGLVMGLGIGTGLKS
                     RISSGGTDIVSLTLRKRTGKDVGSLSLMVNGAILAFAGILFGWQYALYSMVSIFVSSR
                     VTDAIFTKQKKMQATIVTSHPERVIHMIHKRLHRGVTSINDAEGTYKHEQKAVLITIL
                     TCEEYPEFKWLMLKTDPQAFVSVAENVRIIGRFVEDD"
     gene            6733..7611
                     /locus_tag="VHC05_001407"
     CDS             6733..7611
                     /locus_tag="VHC05_001407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEQ5402707.1"
                     /translation="MSIDQRLQLKKFCFIILGAAIYAFAFVYFYMANRIAANGLAGLT
                     LVGKALFEIDPSLIGYLINLPLVLLGARCFGKRAMVYTVMGILSLYFFVWLFQRFPLV
                     VDLDHDNLVVSLMAGIIGGLGGGLVFRNGGTIGGADIIAKLLEDKLGLQLNQALLGID
                     LFVMIVSLTYISLPQMMYALIASFMYGQIVRLVQQGGYSARGIFIVSEQAEKIARFIM
                     DELGRGVTYLTGEGAYSGRRKKVIYVALGRRDIRELKAFLTQVDPNAFITYFDVNEVN
                     SPEFLTIKSKYHKKRK"
     gene            7654..8526
                     /locus_tag="VHC05_001408"
     CDS             7654..8526
                     /locus_tag="VHC05_001408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011185083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEQ5402708.1"
                     /translation="MAHHDKLTKLLKLFLIALGVAIYTFGFVNFNMANALAEGGVAGI
                     TLILNAHFGINPAYSSLLFNLPLFILGAKIFGKRSLALTIYGTVLMSAFIWMWQKVPI
                     ELGLENDMMLVAVVAGLFSGIGSGIVFRYGATTGGTDIIGRIAEEKFGAKLGQTLLLV
                     DALVLTASLTYVDLKHMLYTLVASFVFSQMISVVQNGGYTIRGMIIITKHSEAAAQAI
                     LTEINRGVTYLKGQGAYSGNDYNIMYVTLNPTEVREVKRILAGLDPDAFISIIDVDEV
                     ISSDFKIRRRNYDK"
     gene            complement(8553..8861)
                     /locus_tag="VHC05_001409"
     CDS             complement(8553..8861)
                     /locus_tag="VHC05_001409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HEQ5402709.1"
                     /translation="MPSEKEILDALSKVYSEQVIQADDYFRQAIFELASQLEKEGMSS
                     LLATKIDSLINQYILTHQFDAPKSIFDLSRLVKTKACHYKGTAISAIMLGSFLSGGPK
                     "
     gene            complement(8949..10640)
                     /locus_tag="VHC05_001410"
     CDS             complement(8949..10640)
                     /locus_tag="VHC05_001410"
                     /EC_number="6.1.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015632348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine--tRNA ligase"
                     /protein_id="HEQ5402710.1"
                     /translation="MDTKTLIASEIAKVVPELEQDAIFNLLETPKNSDMGDLAFPAFS
                     LAKVLRKAPQMIASELAEQIDESQFEKVVAVGPYINFFLDKAKISSQVLEQVITAGSD
                     YAQQDEGQGRNVAIDMSSPNIAKPFSIGHLRSTVIGDSLAHIFAKMGYQPVKINHLGD
                     WGKQFGMLIVAYKKWGDEAAVQAHPIDELLKLYVRINAEAETDPTVDEEAREWFRKLE
                     DGDKEATELWQWFRDESLLEFNRLYDQLHVTFDSYNGEAFYNDKMDEVLELLEAKNLL
                     VESKGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKRTYDFAKSVYVVGNE
                     QAAHFKQLKAVLQEMGYDWSDDMTHVAFGLVTKGGAKLSTRKGNVILLEPTVAEAINR
                     AASQIEAKNPNLADKEAVAHAVGVGAIKFYDLKTDRMNGYDFDLETMVSFEGETGPYV
                     QYAHARIQSILRKADFTPSATTTYSLADAESWEIIKLIQDFPRIIKRTSDNFEPSIMA
                     KFAINLAQSFNKYYAHTRILDDNSERDNRLALCYATATVLKEALRLLGVDAPNEM"
     gene            10931..11368
                     /gene="argR"
                     /locus_tag="VHC05_001411"
     CDS             10931..11368
                     /gene="argR"
                     /locus_tag="VHC05_001411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEQ5402711.1"
                     /translation="MNKMERQQQIKRIIQAEHIGTQEDIKNHLQKEGIVVTQATLSRD
                     LREIGLLKLRDEQGKLYYSLSEPVATPFSPEVRFYVLKVDRAGFMLVLHTNLGEADVL
                     ANLIDNDAIEDILGTIAGADTLLVICRDEEIAKRFEKDLAAGL"
     gene            11365..11717
                     /locus_tag="VHC05_001412"
                     /pseudo
     CDS             11365..11717
                     /locus_tag="VHC05_001412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003053122.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="RicAFT regulatory complex protein RicA family
                     protein"
     gene            11704..14259
                     /gene="mutS"
                     /locus_tag="VHC05_001413"
     CDS             11704..14259
                     /gene="mutS"
                     /locus_tag="VHC05_001413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="HEQ5402712.1"
                     /translation="MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAA
                     QLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLIELGYKVAVAEQMEDPKQAVGVV
                     KREVVQVITPGTVVDSAKPDSANNFLVAIDFDGCRYGLAYMDVSTGEFCVTDLADFTS
                     VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELT
                     AAGKLLQYVHKTQMRELSHLQALVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLY
                     WLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFIERTDLSNSLKGVYD
                     IERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFNSAYVDKLVNDIDSLPELEY
                     LIRTAIDPDAPATISEGSIIRNGFDERLDHYRKVMREGTGWIADIEAKERQASGINNL
                     KIDYNKKDGYYFHVTNSNLSLVPDHFFRKATLKNSERYGTAELAKIEGQMLEAREESS
                     SLEYDIFMCIRAQVETYINRLQKLAKILATVDVLQSLAVVAETNHYIRPQFNDNHVIT
                     IQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQM
                     GSFVAADHVDLPLFDAIFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDE
                     LGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHELTDLSTKLTSLVNVHVATLEK
                     DGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIMSVPP
                     QVESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL"
     gene            complement(14655..15308)
                     /locus_tag="VHC05_001414"
     CDS             complement(14655..15308)
                     /locus_tag="VHC05_001414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402713.1"
                     /translation="MWSSIFNFKENIVKKKLVMMLTLLISICAISVRANESGDLFTTI
                     GQSHLPGVTVAPFKTGDTTINVNLDPYGYVYGFVTSSNGNKIKKTENKTYEIPCSILE
                     KQDNPNCEGRKWTVSGNRADGGGNYTVQLEKPLAEGDKVTLSFADDGNLYFGQLVFED
                     GKTHNERLQKERDAEEQQYAEVLFKRSIEEESKKTWHQRLSDSIQDQWWNFKDWLRG"
     gene            complement(15473..15856)
                     /locus_tag="VHC05_001415"
     CDS             complement(15473..15856)
                     /locus_tag="VHC05_001415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003058801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ArpU family transcriptional regulator"
                     /protein_id="HEQ5402714.1"
                     /translation="MSKKNAIRKLKEFHRWQRIANSLDLTYTELYQFDIEYHPTRRKH
                     LEISRECALEELDAIRYAINQLSKVEYRQILIECYLISEEKTQQDIMEELNRSQSWYY
                     ESKKRALLEFVEFYRDGALKNNVRL"
     gene            complement(15831..16040)
                     /locus_tag="VHC05_001416"
                     /pseudo
     CDS             complement(15831..16040)
                     /locus_tag="VHC05_001416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889234.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1492 domain-containing protein"
     gene            complement(16092..16292)
                     /locus_tag="VHC05_001417"
     CDS             complement(16092..16292)
                     /locus_tag="VHC05_001417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402715.1"
                     /translation="MNLCQYLGKDIKVTFVDGQVLEGHCNTFTGKPDTEDELYDEITI
                     KTDKNPYIGFNESEIKSIEIVK"
     gene            complement(16367..16780)
                     /locus_tag="VHC05_001418"
     CDS             complement(16367..16780)
                     /locus_tag="VHC05_001418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1492 domain-containing protein"
                     /protein_id="HEQ5402716.1"
                     /translation="MLPEQIKSKLERIKHLDIEIKGLYYELQYIDDSLFQKSTLTPSK
                     VKTSQDNGIEKHLLNQLELKDKITESIHKLIQERLKITELINLLDAPLERTVLRMYYV
                     NHLEVWKIAEQLSKGEATVYRKLREAIKHLSEVVQ"
     gene            complement(16972..17208)
                     /locus_tag="VHC05_001419"
                     /pseudo
     CDS             complement(16972..17208)
                     /locus_tag="VHC05_001419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000648623.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="phage antirepressor protein"
     gene            complement(17235..17849)
                     /locus_tag="VHC05_001420"
     CDS             complement(17235..17849)
                     /locus_tag="VHC05_001420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Bro-N domain-containing protein"
                     /protein_id="HEQ5402717.1"
                     /translation="MRTETWNGYTIRFVEHQGEWWAVAKDITNALGLKQPSRAISTLK
                     GVTKSKTLTKGGEQELSIINEKDIYRLVFKSRKPEAEAFQEWVFETIKQLRQSIGLEG
                     FQVFRMFDKEHQKQAMNRLVNCLQNATKKDLIKANTIANKAVSDLYGYPKMVSKNEMT
                     ENMLRDREPILDETVELIKVKEKYGLNFSVSEAIYNQNTIKKAQ"
     gene            complement(17863..18060)
                     /locus_tag="VHC05_001421"
     CDS             complement(17863..18060)
                     /locus_tag="VHC05_001421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017644139.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5402718.1"
                     /translation="MKNNFRVLLAKRRKKVSDVAKSTGLSSGTLISLYYERTKRPDIE
                     TLQKVADYLEVTLDELLTVED"
BASE COUNT         5324 a         3223 c         3627 g         5937 t
ORIGIN      
        1 aaataatatc aaacatttct tcaaaattaa agacagtcaa ttcattgatg gtactggttc
       61 taaaacttct agcgaggtta taactttttt caccaacagt aatgtcaatg tcatctttct
      121 tgtgaaaagt atccatttca gtttcatcag aagccaaaaa attttttctt tgaatattga
      181 aatttgcgaa tgtcttggaa agtctaagac agctggattg tattgaaatt aagtcatcgt
      241 ccgaaaaaga atacattctt ttatctacag tttccaaatc tctaaataaa atagagctga
      301 agtagtggta aaacatattt tcaacaaact tggcaatatc tccaaaaata atttctttat
      361 agtccgagtc ggtttgagta ttcaaataaa gcaatattga agcggtaact tgtcgctttc
      421 ccttttcaac ttggctaact tgacctgcat tacctaggtc actttacttt aaattatact
      481 tttttcttaa acatttgata cgagtaggta tttcttgtga gtaattttca tcaaaaaatt
      541 tcatagataa gccccctata aacatggaaa agtggtaaaa atagttgtta tcctagttga
      601 ttaaaaaaat ctctgatttc ctcatctttt ataaaataat atataatttt cccctctctt
      661 ctagtgtcca agatgttttg attggctagt ttacgaagat ggtgggaggc agatgccata
      721 ctgagattta gtaaacaggc tatatcgcag acacagagtt cttcaacagt aaggagataa
      781 aagatgatat ttatctgttt attatcggta aactttgata aaatacgaag tgatttttgg
      841 actttttcct tttcaaggta gttcgttgcg gttgtaacat tttgttgatt tataacattc
      901 acttggcaga tactatcttt tttcataata ttttctccta gcctaacaca gcccatagca
      961 tgtcaaaact gttgttttca atcaggatat atatccccaa tcctaaataa acaacggcaa
     1021 taaaccatct gctatatttt tccaaaattt ctccaacaga agggacttgt gccaattttt
     1081 gggcagaaaa aaccaagaga taaatcatga ctagaaaggt aagtaaagcc actatcaaat
     1141 tcgctaaatt taaggtagta aaatacggga caaagacacc aatattgtca gcaccacaac
     1201 ttgcaaaagt aatcatagcg actagaaaaa tcaggttttt attatctttg cgcaaacctt
     1261 ctttggcaat agcttctcca tcagaatctc ctaaaagcaa aactttgagg cctaggaaaa
     1321 ttggaatcaa accgagcaaa cctaaaatct ctttactagg aatataatct aagacaaatg
     1381 caaaaagcaa acttagcaat attagactaa cagagcctag aaattgtcct aaatagatgt
     1441 taatgatgtc ttttctgctt tttcttttgg caaaaaataa cattaggata ataagtaagt
     1501 ctacggctgt cccagaatac aggattattg aagtaacaac attttgaatc ataaaacacc
     1561 tcattcaaat atatttttga atgaatttta acattaaact ttgtagatgt caatttcagc
     1621 tccaccaaaa tatagataag aagttagtgt accaaatata aaaaagccct gccatccaaa
     1681 tgataacagg gcttaacttc aatatccaaa tgatatattc atctaaaaaa ggtagagtaa
     1741 aaggtagagt tcttattgat ttatattaca atgtaatgaa cttcaaaaaa ttcaaaaatc
     1801 gcttaaaatc aatgttttga cgtctaatga cgtgtagtga accccttact taacttctgt
     1861 aaatgtaacg tgtttacgta attttggtga gtattttttc aattgaagac ggtctggagt
     1921 gttacgtttg ttttttgaag taaggtacaa gcgttcacca gattctttat gttcaagtgt
     1981 aatatttacg cgcatggtat ctcccttcta ttatttagct tcgttagctt tagcgatttt
     2041 acgtcctttg tagtatcctt taagggatac acggtgagaa cgtgagtaat ctccagtagt
     2101 ttcgtcgaat tgtacagatg gagctgtcaa tttgtagtgt gtacgacgtt tgtttttctt
     2161 cgcttttgac gtgtgacgtg caggtactgc cattttcttg ttcttccttt cgatgtgtaa
     2221 gttttgattt tcatcaactt cactatgata acatatcttt tttgtaaagt aaagttactt
     2281 gacaaaactt tttactttta caatttcatg gtgaaaatac tatcaaacta aagcaaatga
     2341 tatatgcttg tttaaaatat aagaaaaaat ggtagaatgt ttaaagagaa aactaatcaa
     2401 agaggtaaac ttatgaaact tcaaaaacca aaagggactc aggatattct gcctggggat
     2461 gctgcgaaat ggcagtatgt ggaatctgtt gcgcgtgata cgtttagcca atacaattat
     2521 ggagaaattc gtactcctat gtttgaacac tacgaggtaa tctcgcggtc tgtaggtgat
     2581 acgactgata ttgtgacgaa ggaaatgtat gatttctatg ataaaggaga tcgtcacatt
     2641 accttgcgac cagagggtac agctccagtg gtgcgttctt atgttgaaaa taaattgttt
     2701 gcgccagagg tccaaaaacc tgtcaaactt tattatatcg gttccatgtt ccgctacgaa
     2761 cgtcctcaag ctggtcgttt acgtgaattt caccagattg gggtagaatg tttcggcgct
     2821 gctaatccag caacagatgt tgaaaccatt gcgatggcct atcacctctt tgaaaaattg
     2881 ggcattaagg atgtcaccct tcatttaaat agtttgggga gtcctgagag tcgtgcagct
     2941 tatcgtcaag ccttgattga ctacttaaca ccaatgcgtg atcaattatc taaagatagt
     3001 caacgtcgct tggatgaaaa cccactgcgc gtgcttgatt ctaaagaaaa agaagataaa
     3061 ctagccgttg aaaaagcgcc ttctattttg gattacttag atgaggaaag tcaggcgcac
     3121 tttgaggcgg tccaagatat gcttgaagca cttgacattc cttatgtgat tgacaccaat
     3181 atggtgcgtg gccttgatta ctataaccac actatttttg aattcatcac gtctgtggaa
     3241 ggttctgact taactatctg tgcgggtgga cgttatgata gtttggtagg ttattttggt
     3301 gggcctgaga ctccaggatt tggctttggt cttggtttag aacgtctctt gatgattatt
     3361 gaaaagcagg gcattacctt gccaattgag acagagatgg atatttacct tgctgtgtta
     3421 ggtgatggtg ctaatagcaa agctttagaa ttggttcaag ccattcgccg tcaagggttt
     3481 acagctgaac gagattacct tggccgtaag attaaggctc agtttaaatc agctgatacc
     3541 tttaaagcaa aattggtaat gactttagga gaaagtgaag ttgaagcagg caaagctgtg
     3601 attaagaata atcgtagccg tcaagaagtg gaagtcagtt ttgaagatat gatgaccaac
     3661 tttgaaaaca tctcagagca attattgtct taatgatttt attgtcgtca taagcttgtg
     3721 ttgatatgat tgtttagaag ataatcacta aaacaggtgt cacttctctt tttagaaggg
     3781 agttgcacct gtttgttttc tgtaagggga ttgattagct ttcttagtat tctgtgagga
     3841 cacctgatat gtcaaaatgc tgacgactca gtattcttgc tttatcttta gaaaaactct
     3901 ttttaaatgg gtggggtttt taagggcttt ttgctataat agtagggaat gaattaattg
     3961 atttatatag tgaaaggaat tggaaacgag caggtttcac aggattctgt ttgttttagg
     4021 gaatttattt atgaaacgta gcatgtatgc agggcgtgtt cgcgaagaac acattggaac
     4081 gacaatcaca ttgaaaggat gggtcagtcg tcgtcgtgac ttgggtggtc tcatctttat
     4141 tgatttacgt gaccgtgagg gtgtgatgca attagtcatt aaccctgagg aagtttccag
     4201 tgatgtgatg gcaactgctg aacgcctacg tagtgaatat gtgattgaag tggaaggttt
     4261 tgttgaagct cgacaacaag ccaatgataa gttggcgaca ggaatggttg agttaaaagt
     4321 atctgctttg accattttaa acacagctaa aacgacgcct tttgaaatta aagatgacgt
     4381 tgaagtaagt gatgacacgc gtttacgtta ccgttactta gatttacgac gtccagaaat
     4441 gttagaaaac ttcaagctac gtgcaaaagt gactcattct atccgtaatt accttgatga
     4501 ccttgagttt attgatgtcg agacacctat gttgacaaaa tcaactccag aaggtgcgcg
     4561 tgactatctg gtaccaagtc gtgttagcca agggcatttc tatgctttgc cacaaagtcc
     4621 gcaaattacc aaacagttat tgatgaatgc tggctttgat cgctattatc aaattgtgaa
     4681 atgtttccgc gatgaagatc tacgtggtga ccgtcaacct gagtttacac aagttgactt
     4741 ggaaacgtca ttcctttctg aacaagagat tcaagacatc gttgaaggca tgattgctaa
     4801 agtgatgaaa gagacaaaag aaatagatgt aaccctacca ttcccacgta tgagctacga
     4861 tatagcaatg aatagctacg gctctgataa accagacaca cgttttgaga tgcttttaca
     4921 agacttgaca gtaactgtca agggaattga cttcaaggtt ttctcagaag caccagctgt
     4981 caaggcgatt gtggtgaagg gaaatgcaga tcgatactct cgtaaagata ttgacaaatt
     5041 aactgagttt gccaaacaat ttggtgctaa aggccttgcc tgggttaagg tgacagatgg
     5101 tcaattggca ggcccagtag ccaagttctt gatagctatt gagacagagt tgtcaagcca
     5161 attaaaactt gctgagaatg atttggtttt atttgtagcg gatactcttg aggttgctaa
     5221 taatacatta ggtgcccttc gtaatcgtat tgccaaggac cttgacatga ttgatcagtc
     5281 gcagtttaat ttcctttggg tggttgattg gccaatgttt gagtggtcag aagaagaagg
     5341 acgttatatg tcagctcatc accccttcac tcttccaacg ccagaatctg ctcatgagtt
     5401 agagggtgat ttggctaagg tacgggcaat tgcttatgac atcgttttaa atggttacga
     5461 gcttggtggt ggtagcctgc gtatcaatca aaaagagatg caagagcgca tgttcaaggc
     5521 tcttggcttt accgctgatg aagctaacga ccaatttggt ttcttactag aagcgatgga
     5581 ctacggcttt cctcctcatg gtggcttggc aattggtctt gaccgttttg tcatgttgct
     5641 tgctggaaaa ggcaatattc gagaagttat tgccttccct aaaaataaca aagcctctga
     5701 tccaatgacg caagcaccta gtcttgtttc tgaaaaccaa ttagaagaac tcagtcttca
     5761 aatagaaagt catgattaag aaaacaacct ataggaaaaa agttaaatat gtcattagta
     5821 gaggggccaa gaaagttggc ctactccacg ctctaagaag tatttcaaga gaaaaatatg
     5881 cagagaagat ttcggcttct ctgctttatg gcattctctc tagtattgct gtgaattttt
     5941 tcttccagcc tgggcatgtt tattcaagtg gagcaactgg tctagcacag gttttttcag
     6001 ctcttagtca tcgtctttta ggctatgatt ttcccatcgc ctttgcgttt tatttgatta
     6061 atattccttt gcttatttta gcttggtata aaattgggca tcaatttacc atttttacct
     6121 ttatcacagt cagcatgagt tctttcttta ttcaaatcat gcctcaagtg acgctgacga
     6181 ctgatcctct tatcaatgct atttttggtg gtttggttat gggactggga attggtacag
     6241 gtctcaaatc acgtatctct agtgggggga ctgatattgt cagtttgacc cttagaaaac
     6301 gaacaggcaa ggatgtgggc agtctctcat tgatggttaa tggtgcaatt ttagcctttg
     6361 cagggatttt atttggctgg cagtacgccc tttattctat ggtctctatc tttgtatcaa
     6421 gtcgtgttac ggatgccatt ttcaccaagc aaaagaaaat gcaggcaact attgttacca
     6481 gccatccaga gcgtgtgatt catatgatcc ataaacgtct gcatcgcggg gtgaccagta
     6541 tcaacgacgc agaagggact tacaagcatg aacaaaaagc agttttgatt accattttga
     6601 catgtgaaga atatccagaa ttcaaatggc tgatgttaaa aacagaccca caagcctttg
     6661 tttcagtggc tgagaatgtt agaattatcg gtcgttttgt ggaagatgat taagaaaaac
     6721 acaggaggtg tcatgtcaat tgaccaacgt ttacagttaa agaaattttg ctttattatt
     6781 ttaggagctg ctatctacgc ctttgctttt gtttattttt acatggctaa tcgcattgca
     6841 gccaatggtt tagctggtct caccctagtt ggtaaggcac tttttgagat tgatccttct
     6901 ttgataggct atttgattaa tttgcctttg gtcttgttgg gagctagatg ttttgggaaa
     6961 agagccatgg tttacacagt aatgggtatt ttgtcacttt acttttttgt gtggctgttt
     7021 caacgctttc ctttggtcgt tgacttggac catgacaatt tagtcgtttc cttgatggct
     7081 ggaattattg gtggtctagg tggcggtctt gtgtttcgca atggtggaac catcggtgga
     7141 gcagatatta ttgctaagtt attagaagac aagttaggac tacagctgaa tcaagctctt
     7201 ttaggcattg atctttttgt catgattgtc tctttgactt atatttccct gccgcaaatg
     7261 atgtatgctc tgattgctag ctttatgtat ggtcaaattg ttcgcttggt acaacaaggt
     7321 ggttattcag cccgtggcat ttttatcgtt tcagaacaag cggagaaaat tgcccggttc
     7381 atcatggacg aattgggaag aggagttact tatctaacag gtgaaggagc ctattctggt
     7441 cgccgtaaaa aagtgattta tgtggctttg gggcgaagag atattaggga attaaaagct
     7501 tttttaactc aggttgatcc caatgccttt atcacttatt ttgatgttaa tgaagtcaat
     7561 agcccagaat ttttaactat taaaagcaaa taccataaaa agaggaaata aatgagcatt
     7621 agagttgcct gcgaagaata gtgaggataa aggatggcac atcacgataa attgactaaa
     7681 ctactaaaac tgtttttgat tgccctaggt gtagccattt ataccttcgg ttttgttaat
     7741 tttaacatgg ctaatgcttt ggctgaaggt ggtgtggcag gaataacctt gattttaaac
     7801 gcgcattttg ggattaatcc tgcttactct tctctcttat ttaatcttcc actttttatt
     7861 ttaggggcaa agatttttgg gaagcgttct ttggctctaa ccatctatgg aacagttctg
     7921 atgtccgctt ttatctggat gtggcaaaaa gttcctatcg aacttggctt ggaaaatgac
     7981 atgatgttgg tggctgtagt ggcaggtctc ttttcaggga ttgggagtgg cattgttttt
     8041 cgctatggtg caaccacagg tggaacggat attattggtc gcattgcaga agaaaaattt
     8101 ggagctaagc taggtcaaac tttgcttttg gtggatgctc ttgtattgac agcttcgttg
     8161 acttatgtgg atttaaaaca catgctttat actttggtgg caagctttgt ttttagccaa
     8221 atgattagtg tggttcaaaa tggtggttac actatccgtg gaatgattat tattaccaag
     8281 cattcagagg ctgccgctca agctatccta accgaaatca atcgtggagt gacttacttg
     8341 aaaggtcaag gagcttactc tggtaatgat tacaatatca tgtatgtgac cttgaaccca
     8401 actgaagttc gggaagtcaa acgtatttta gctggtttgg atccagatgc ctttatctcc
     8461 attattgatg tggacgaagt tattagctct gattttaaaa ttcgccgaag aaattatgat
     8521 aaataaaaat acaggtcaaa cagcctgtat ttttattttg gtcccccact taagaaacta
     8581 ccaagcataa tagctgatat agcagttccc ttgtaatggc aagcttttgt ttttaccaag
     8641 cgactaagat caaatatgct tttaggagca tcaaattgat gtgttaagat gtattgattg
     8701 ataagtgagt caatttttgt agctagtagt gagctcatcc cctctttttc aagttgactg
     8761 gcgagctcga agatcgcttg acgaaaataa tcatctgctt gtattacttg ttcgctataa
     8821 actttactaa gagcatctaa tatttctttt tctgatggca tggcattctc ctgtaacata
     8881 ttgtgctatt attataatat aaaaaactaa gactgtcata aatgtgacag ccttagtgat
     8941 gttattactt acatttcatt tggtgcgtca acaccgagta agcgaagcgc ttctttaaga
     9001 acagtagcag ttgcatagca gagagctaag cggttatcac gttctgagtt gtcgtcaaga
     9061 atgcgagtgt gagcataata tttgttaaag ctttgggcta agttaatagc aaatttagcc
     9121 ataatagaag gctcaaagtt atctgatgtt cgcttgataa tgcgtgggaa atcttggata
     9181 agtttgataa tttcccagct ttcagcatca gctaaactgt aagtggtggt tgcagatggc
     9241 gtaaagtcag ctttacgtag aatagattgg atacgagcgt gagcgtattg aacataaggt
     9301 ccagtttctc cttcaaagga aaccatggtt tcaaggtcaa agtcataccc attcatacga
     9361 tctgttttga gatcgtaaaa cttgatggca ccgacaccaa cagcgtgtgc aacagcttct
     9421 ttatcagcaa gatttggatt tttcgcttca atttgagaag cagcgcggtt aatggcttca
     9481 gcaaccgtag gttcaagaag aataacatta cctttacgtg ttgataattt agcaccgcct
     9541 tttgtgacaa gtccaaaagc aacgtgtgtc atatcatctg accaatcgta acccatttct
     9601 tgtagcactg cttttaactg tttgaagtga gcagcttgct cattaccaac aacataaacg
     9661 gatttagcaa agtcataagt gcgtttacgg taaagtgcgg cagctaggtc acgggtaatg
     9721 taaagagtag cgccatctga ttttttgatc aaggcagggt gttcaatgcc gtatttttca
     9781 aggttaacaa cttgggcacc tttggattct acaagaaggt ttttcgcttc taatagctca
     9841 agaacctcat ccattttgtc attatagaag gcctcaccgt tgtaactatc gaaggtgaca
     9901 tgtaattggt cataaagacg gttaaactca agcaaactct catcacggaa ccattgccat
     9961 aattcggtag cttctttgtc gccatcttcc aatttacgga accattcacg agcttcttca
    10021 tcgacggttg gatcagtttc agcttcagca ttgatacgaa cgtaaagttt taagagttca
    10081 tcaataggat gtgcctgaac agcagcttcg tctccccatt ttttataggc aacaatgagc
    10141 ataccaaatt gtttacccca gtcaccaagg tgattgattt ttacaggttg ataacccatt
    10201 ttggcaaaaa tgtgagcgag actatcacca ataactgttg agcgaaggtg accgattgaa
    10261 aatggtttag caatgtttgg gcttgacata tcaatagcaa catttcgccc ttgaccttcg
    10321 tcttgctgag catagtctga acctgctgta atcacttgtt caaggacctg tgaggaaatc
    10381 ttagctttat caaggaaaaa attgatgtaa gggccgacag ctacgacttt ttcaaattgg
    10441 ctctcatcaa tctgttcagc taactcgcta gcaatcattt gaggggcttt gcgaaggact
    10501 tttgctaagc taaaagctgg aaaggcaagg tctcccatat cagaattttt tggggtttca
    10561 agcaagttaa aaatagcatc ttgttctaat tctggaacaa ctttagctat ttcacttgcg
    10621 attagagttt tagtatccat acagcgtctc ctaaaaattg tttgtcaccc tattctaaca
    10681 tatttcttta aaataaacga ggagaggatt gataaattat actgaaactt tcaaggaaat
    10741 gaattgcttg aggttgttat ttttctgaaa atgttataaa aagagaaatg aggtttcttt
    10801 tcaacagttt tcaagtgaaa ttctagttgg atttgataaa aaattgctga aaatagctgg
    10861 gcgaagatga aataatacac tttttttgtt ataatttgag aggataatta tacaattggg
    10921 gtgatatatc atgaataaaa tggagcgtca acagcagatt aagcgaatca ttcaagcaga
    10981 gcatattggc acacaagaag atattaaaaa tcaccttcaa aaagaaggca ttgtggtcac
    11041 ccaagcaact ctatctcggg acttaagaga aattggcctt ttgaaattga gagatgaaca
    11101 aggcaaactc tattatagtt tgtctgaacc cgttgcaaca ccatttagtc ctgaggtgcg
    11161 tttttatgtt ttgaaagttg atcgagcagg ttttatgctg gttctccata ccaatttagg
    11221 agaggctgat gttctagcta atttgattga caatgatgcc attgaagata ttctaggaac
    11281 cattgctggt gcggatacct tgcttgtgat ttgcagagac gaagagattg ctaaacgctt
    11341 tgaaaaagat ttagctgcag gcctatgact agctatcaag agtctttgac acaattgatt
    11401 cttgctatcc atgaattcta gtatcgttgc ttataaagaa gtgcagcaat agctgtctaa
    11461 gctccgtgat tttaaaaagt aagcttatca gatgaaacgc tatcaacaag atgccctgct
    11521 tttcaaaaaa aatagataaa gaaaaggctg cgacagtatc tgcaagcagg acaaaagaac
    11581 tagaagatag gctcagtcat cagccattaa ttgatgatta tcgagaaaag atgcaagatg
    11641 caagtgatgt gattcagtat atcaccaaac gtatagaaga tcagttaaac aaggagttaa
    11701 caaatggcaa aaactaacat ttctcctgga atgcaacagt atctggacat caaaaaagat
    11761 tatccagatg cttttttgct ttttaggatg ggtgactttt atgaattatt ttacgaggac
    11821 gctgtcaaag cagcacaact cttagaaatt ggtttgacca gtcgcaacaa gaatgcggaa
    11881 aatccaattc ccatggcagg cgtgccacat cattctgccc aacaatacat tgatgtgtta
    11941 attgagttgg gttacaaggt tgctgtcgca gaacaaatgg aagacccaaa gcaagctgtt
    12001 ggggtggtga agcgtgaggt cgttcaagtc ataactcctg gaacggttgt ggattcagct
    12061 aagccagata gcgccaataa ctttttggta gctattgact ttgatggttg ccgttatgga
    12121 ttggcttata tggatgtgtc cacaggtgaa ttttgcgtga cagatttggc ggactttacg
    12181 agtgttcgta gcgaaatcca aaacctcaag gcaaaagaag tcttactagg ttttgattta
    12241 tctgaagaag aacagacgat tttggtcaag cagatgaatt tgctgctttc ttatgaagaa
    12301 acggtctatg aagataaatc tttaattgac ggtcaattga caacggtaga actgacagcg
    12361 gcaggaaaac tcttgcaata cgttcacaaa acacaaatgc gagaactcag ccacttgcaa
    12421 gccttggttc actatgaaat caaggattat ttgcagatgt cgtatgccac taagtcaagt
    12481 ctagatttgg tagagaatgc tagaacgaat aaaaaacatg ggagtctgta ttggctgtta
    12541 gatgaaacca agacagctat ggggatgagg cttttgcgct catggattga tcgacctttg
    12601 gtttctaaag aagctatttt agagcgtcaa gaaattattc aagtttttct gaatgctttt
    12661 attgagcgaa cagatttaag caatagctta aaaggtgttt acgatatcga acgcttatct
    12721 agccgtgtgt cttttggcaa ggcaaatccg aaagatttac ttcaattggg gcatacctta
    12781 gcccaagtgc cttatatcaa agccatatta gagtctttta acagcgctta tgttgacaaa
    12841 cttgtcaatg atattgacag tttgcctgag ttggaatact tgattagaac agccattgat
    12901 ccagatgcac cagcaactat tagtgaagga agtattatcc gcaatggttt tgatgagcgc
    12961 ttggaccatt atcgtaaagt aatgcgagag gggacaggct ggattgcgga tattgaggcc
    13021 aaagagcgtc aagcaagtgg cattaataac ctaaaaattg attacaataa aaaagatggt
    13081 tattattttc acgttacgaa ttcaaatctt agcttagttc ccgaccattt tttcagaaag
    13141 gcaactttaa aaaattctga gcgttatgga acagcagaat tggctaagat tgaaggtcag
    13201 atgttagagg ctagggaaga gtcatctagt ttagaatacg atatttttat gtgtattcga
    13261 gctcaagttg aaacctatat taatcgttta cagaaactgg ctaaaatttt ggcaacggta
    13321 gatgttttgc aaagtttagc agtcgttgct gaaaccaatc attatatccg gccgcagttc
    13381 aatgataatc atgtgattac aattcaagaa ggtcgtcacg cggttgttga aaaggttatg
    13441 ggagtgcagg aatacattcc caatagtatc tcttttgacc aacagaccag tattcagctg
    13501 attacaggtc caaatatgag tggtaagtcg acttatatga gacagctggc cttaacggtt
    13561 atcatggccc agatgggttc atttgtggct gctgaccatg ttgatttacc tttatttgat
    13621 gcgattttta cgcgtattgg ggctgctgat gatttgattt ctgggcaatc aacctttatg
    13681 gtggagatga tggaagcaaa ccaagcaatc aaacgcgcaa gtgacaactc tcttattcta
    13741 tttgatgaac tgggacgagg tacggcaact tatgatggta tggctttagc ccaggcaatt
    13801 attgaatata tccatgatag agttggtgct aagaccatat ttgcaacgca ttatcatgaa
    13861 ttgacagact tgtcaactaa gttgacaagt ctagtcaatg ttcatgtagc aacgcttgaa
    13921 aaagatggcg atgttacctt ccttcataag attgctgagg gaccggcgga taaatcttac
    13981 ggtattcatg ttgcaaaaat agcaggactg ccaaaatccc tattaaagag agcagacgaa
    14041 gttctgaccc gtttagaaac acagtcacga tctactgaga taatgtcagt ccctccacaa
    14101 gttgagtcaa gcagcgctgt tagacagggg caattatccc tttttggtga tgaagagaaa
    14161 gctcatgaga ttaggcaagc actggaagct attgatgtca tgaatatgac cccgcttcaa
    14221 gcaatgacaa ccctttacga attgaaaaag ttgttatagt ttttcagctg aaaatgaaaa
    14281 agatgctttc tatattgaag gcatcttttt gttctgtcaa aaacggtccg aggccttcgg
    14341 ctatttatta agtgtgttat aatagtccat aagaatgcga ggaaattatg acaaacatta
    14401 ttggacttgg attggcagtc tttacagggt attgacagtc cttaagcatt gttatgactg
    14461 tgtttttgaa aaaatatagg ttttaagttt ccttagactt ccctcaaaag tccacaaaaa
    14521 ggtgaacaaa aaagaccttt acaggtcctt tacacaatga gttcagcagg caagaactag
    14581 cgtggtttaa atactacgct ttttagtttg ccctatggct tattatagca cgattagtgt
    14641 cattgaggaa aaaactaccc tctcaaccag tctttaaagt tccaccattg gtcttggatg
    14701 ctatcgctca agcgttgatg ccaagttttt ttggattctt cttcgataga acgcttgaat
    14761 aacacctccg catattgttg ctcttcggca tctctctctt tttgaagacg ttcattatgt
    14821 gtttttccat cctcaaatac aagttgccca aagtatagat tcccgtcatc cgcaaaagat
    14881 aaggtaactt tgtctccttc agcaagtggt ttttccaatt gaactgtgta gttgcctcct
    14941 ccatcagcac gattgccact tactgtccat ttccttcctt cgcagtttgg attatcttgt
    15001 ttctccaaaa tagagcaagg aatttcataa gttttgtttt cggttttttt aattttatta
    15061 ccattacttg aagttacaaa accataaaca tacccatagg gatctagatt aacattaatg
    15121 gttgtatctc ctgttttaaa tggtgctacg gttactccag gtaagtgcga ttgccctata
    15181 gttgtaaaca aatcgccact ttcattagct ctgacactta tagcacatat tgatattaac
    15241 aaagttaaca tcataactaa tttctttttc actatattct ccttaaaatt aaatatcgaa
    15301 ctccacaata ccagttaatc agtcaaaaaa tccattctac tttttgatat tttatgtcta
    15361 atttgacccg ctaagtcaga tttgcaaacg ataccaagtg attttcttct aatcattatt
    15421 ttttagatgg atatgttaat tgtattagag acgtattaat cttaaaccat tgtcataagc
    15481 gaacattatt ttttagcgcc ccgtctctgt aaaattccac aaactcaagc aaggctcttt
    15541 tcttagattc ataataccag ctttgacttc tgttaagttc ttccataatg tcttgttgag
    15601 ttttttcctc actgatcaag taacactcaa ttagtatttg tctatattct actttagaca
    15661 gttgattaat ggcataccta atagcgtcta gttcctctag ggcgcattct cggcttattt
    15721 caaggtgttt tctgcgcgtg ggatggtact ctatatcaaa ctggtaaagc tcggtataag
    15781 ttaaatcaag gctattagcg atacgttgcc atctatggaa ttctttcagc ttacgaatag
    15841 cgttcttctt gctcatctaa cacctctaaa gcttctctat gtagtttgaa cacagtgttt
    15901 cttgagtaac ctagtttatc gagtatctcg tcccatgata agtcatccac gtatctagcc
    15961 ttaataacag ctatctgtct ttcatgttgc aatgtggcaa tcatggccag tctcttgtca
    16021 cgttcctagc tacaatatac tcctttggga ggggacataa taaaaagtaa gtagctatga
    16081 tagtcaagtg cttattttac aatttcaatt gatttgattt ctgattcatt aaaaccaata
    16141 tatgggttct tatcagtttt tattgtgatt tcatcataca actcatcttc cgtatcaggt
    16201 tttcctgtga atgtattaca atgaccttca aggacttgac catcaacaaa agtaactttg
    16261 atatcttttc ctaaatactg gcataaattc attattggtc tcctttctta ggtactgtat
    16321 gggttctact tttataatat tagttcctat agttcaaatc tcacttttat tgaactacct
    16381 cagataagtg ttttatagcc tcacgaagct ttctgtagac tgtggcctct cctttactga
    16441 gttgttcagc tattttccaa acttctaagt gattaacata atacattctt aaaactgttc
    16501 tttcaagagg agcgtctaac aaattaatta attcagtgat ttttaatctt tcctggatca
    16561 atttatggat agattcagtg attttatctt tgagttctaa ttgattaagt agatgtttct
    16621 ctataccgtt gtcttgactt gtttttactt ttgacggagt tagtgtcgat ttctgaaaaa
    16681 gactatcatc tatatactga agttcgtaat aaagaccttt aatctcaatg tctaaatgtt
    16741 tgatacgttc caatttagat tttatttgct caggtaacat tctaaccctc caattatgat
    16801 atactataat caaatctgat attattcaag gatcttcctt gtacccaaga gtcctttccc
    16861 tacaaagttt tgtaggattt ttttgttatt ctaacgtttt taggacactt tcaacaaaat
    16921 cttcatcatg aacttcaata ccgttaacga tatgaattcc agtaaatccc cattgccttg
    16981 ttcaatgtca ttcaaacgct tttgctctgc tttgcgatta tagattagca ctttgtcatc
    17041 aagcatgagc gatacgcctt ccaatacgtt gaaaatttcc tgtgtgattg cttcaaactg
    17101 ttcgcgatct gcatttggta ctttgtcagc gtaaccctgt gctagctcag ctaaatcaac
    17161 accttcatca atccatttct tcaagtcttt gtaagttgtt gctttcataa tcatttctcc
    17221 tttatccacg cgcatcactg cgcttttttt attgtgtttt ggttatagat agcttcagat
    17281 acgctaaaat ttaagccgta tttttcttta accttgatta gttcaaccgt ttcatcaagg
    17341 ataggctcac ggtctcgcaa catgttttct gtcatctcgt ttttactaac catcttagga
    17401 taaccatata ggtcagaaac ggctttgttt gcgatagtgt ttgctttgat aaggtctttc
    17461 ttagttgcat tttgtaagca attgacaagc ctattcattg cctgcttctg atgttcttta
    17521 tcaaacattc taaatacttg gaagccctct aggcctatgc tttgtcttaa ctgtttaatg
    17581 gtttcaaata cccattcttg gaaagcttcc gcctcaggtt ttcgactttt gaatactaat
    17641 ctgtaaatat ctttttcatt gataatagaa agctcttgct ccccaccttt tgtaagggtc
    17701 ttacttttag taaccccctt tagagtcgat atagctcttg acggttgttt taatcccaaa
    17761 gcatttgtaa tatccttggc aacagcccac cattcgcctt ggtgctctac aaatcggata
    17821 gtatatccgt tccatgtttc tgttctcaat aagttttcct ttctagtctt caactgttaa
    17881 taattcatca agtgtaactt ctaaatagtc agcaaccttt tgaagtgttt caatgtctgg
    17941 gcgctttgtt cgctcgtaat ataaagatat taaagtgcca cttgataacc cagttgattt
    18001 tgctacgtct gaaacttttt tgcgtctttt tgctaaaaga actctaaaat tatttttcat
    18061 tttctatctc ctttttctgt ttttacagca aaaatgacaa gaatagttgt c
//
LOCUS       DAUDWO010000040        16876 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.041, whole genome shotgun sequence.
ACCESSION   DAUDWO010000040 DAUDWO010000000
VERSION     DAUDWO010000040.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 16876)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16876)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16876
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.041"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            908..3949
                     /locus_tag="VHC05_001422"
     CDS             908..3949
                     /locus_tag="VHC05_001422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine-rich repeat domain-containing protein"
                     /protein_id="HEQ5402719.1"
                     /translation="MKKHLKTVALTLTTVSVVTHNQEVFSLVKEPILKQTQASSSISG
                     ADYAESSGKSKLKINETSGPVDDTVTDLFSDKRTTPEKIKDNLAKGPREQELKAVTEN
                     TESEKQITSGSQLEQSKESLSLNKTVLNKTVPSTSNWEICDFITKGNTLVGLSKSGVE
                     KLSQTDHLVLPSQAADGTQLIQVASFAFTPDKKTAIAEYTSRAGENGEISQLDVDGKE
                     IINEGEVFNSYLLKKVTIPTGYKHIGQDAFVDNKNIAEVNLPESLETISDYAFAHLAL
                     KQIDLPDNLKAIGELAFFDNQITGKLSLPRQLMRLAERAFKSNHIKTIEFRGNSLKVI
                     GEASFQDNDLSQLMLPDGLEKIESEAFTGNPGDDHYNNRVVLWTKSGKNPYGLATENT
                     YVNPDKSLWQESPEIDYTKWLEEDFTYQKNSVTGFSNKGLQKVKRNKNLEIPKQHNGV
                     TITEIGDNAFRNVDFQNKTLRKYDLEEVKLPSTIRKIGAFAFQSNNLKSFEASDDLEE
                     IKEGAFMNNRIETLELKDKLVTIGDAAFHINHIYAIVLPESVQEIGRSAFRQNGANNL
                     IFMGSKVKTIGEMAFLSNRLEHLDLSEQKQLTEIPVQAFSDNALKEVLLPASLKTIRE
                     EAFKKNHLKQLEVASALSHIAFNALDDNDGDEQFDNKVVVKTHHNSYALADGEHFIVD
                     PDKLSSTMVDLEKILKLIEGLDYSTLRQTTQTQFRDMTTAGKALLSKSKLRQGEKQKF
                     LQEAQFFLGRVDLDKAIAKAEKALVTKKATKNGQLLGRSINKAVLAYNNSAIKKANVK
                     RLEKELDLLTGLVEGKGPLAQATMVQGVYLLKTPLPLPEYYIGLNVYFDKSGKLIYAL
                     DMSDTIGEGQKDAYGNPILNVDEDNEGYHSLAVATLADYEGLDIKTILNSKLSQLTSI
                     RQVPTAAYHRAGIFQAIQNAAAEAEQLLPKPGTHSEKSSSSESANSKDRGLQSNPKTN
                     RGRHSAILPRTGSKGSFVYGILGYTSVALLSLITAIKKKKY"
     gene            3969..4370
                     /locus_tag="VHC05_001423"
     CDS             3969..4370
                     /locus_tag="VHC05_001423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HEQ5402720.1"
                     /translation="MITQEMKDLINNQLAMVATVDAKGQPNIGPKRSMRLWDDKTFIY
                     NENTDGQTRINIEDNGKIEIAFVDRERLLGYRFVGTAEIQTEGAYYEAAKKWAQGRMG
                     VPKAVGIIHVERIFNLQSGANAGKEINSESN"
     gene            complement(4550..5425)
                     /locus_tag="VHC05_001424"
     CDS             complement(4550..5425)
                     /locus_tag="VHC05_001424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HEQ5402721.1"
                     /translation="MPASKKVTIIFILNLSFSLIEFIFGTLFFSGAILADAVHDFGDA
                     IAIGISAILERKAVKKESPNFSLGYKRFSLLGALTTNLILISGSLLVMIETIPKLWHP
                     TIVNYDGMFVLAIFAIIINGFASFIIHSNQTKNEEILSLHFLEDILGWLAIIILSLIL
                     KWKPWYILDPLLSIAIASFILSKALPKLVATANIFLDGVPDSIDYCALHHELSQLPHI
                     VSVNQLNVWSMDGIDHRATIHCCLRESTTEKHCKKSIRLICQRYNINSVTVEIDTSLN
                     EHQHHCSSLSGIEVN"
     gene            5561..6082
                     /locus_tag="VHC05_001425"
     CDS             5561..6082
                     /locus_tag="VHC05_001425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEQ5402722.1"
                     /translation="MTKDRQIKKTKTAIYSAFIALLQKKEYSKITVRDMITLANVGRS
                     TFYAHYESKEMLLKELCEELFHHLFRQKRNVTFEDYLVHILKHFEQNKDSIATLLLSN
                     DPYFLLRFKNELEHDVYPNLRCKYIDKTTIPEVFLKQFVLSSFVETLKWWLHQRQRMS
                     ANELLKYYLELIK"
     gene            6297..6815
                     /gene="rimM"
                     /locus_tag="VHC05_001426"
     CDS             6297..6815
                     /gene="rimM"
                     /locus_tag="VHC05_001426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimM"
                     /protein_id="HEQ5402723.1"
                     /translation="MEYFNVGKIVNTQGLQGEMRVLSVSDFAEERFKKGSQLALFDDK
                     DRFVQEVTIVSHRKQKHFDIIKLKDMYHINAIEKYKGYTLKVSKDNQGDLQEGEFYYH
                     QIIGMAVYEKDRLIGYVKEILQPGANDVWVVKRQGKRDLLLPYIPPVVLNVDVPNKRV
                     DVELMEGLDDED"
     gene            6805..7524
                     /gene="trmD"
                     /locus_tag="VHC05_001427"
     CDS             6805..7524
                     /gene="trmD"
                     /locus_tag="VHC05_001427"
                     /EC_number="2.1.1.228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(37)-N1)-methyltransferase TrmD"
                     /protein_id="HEQ5402724.1"
                     /translation="MKIDILTLFPEMFAPLEHSIVGKAKEKGLLDIHYHNFRDYAEKA
                     RHVDDEPYGGGQGMLLRAQPIFDTIEQIEAKKPRIILLDPAGKPFTQAYAEELALEEE
                     LIFICGHYEGYDERIKTLVTDEISLGDFVLTGGELAAMTIVDATVRLIPQVLGKESSH
                     QDDSFSSGLLEYPQYTRPYDYRGMTVPDVLMSGHHERIRLWRLEESLRKTYLRRPDLL
                     ERYDFSEEERKLLDKIKEALG"
     gene            7536..8528
                     /locus_tag="VHC05_001428"
     CDS             7536..8528
                     /locus_tag="VHC05_001428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HEQ5402725.1"
                     /translation="MKDKAYDITIIGGGPIGLFAAFYAGLRGVTVKIIESLSELGGQP
                     AILYPEKMIYDIPAYPSLTGVELTENLIKQLSRFEDRTTICLKEEVLTFDKVKGGFSI
                     RTNKAEHFSKAIIIACGNGAFAPRTLGLESEENFADHNLFYNVHQLDQFAGQKVVICG
                     GGDSAVDWALALEDIAESVTVVHRRDAFRAHEHSVELLKASTVNLLTPYVPKALKGIG
                     NLAEKLVIQKVKEDEVLELELDSLIVSFGFSTSNKNLKNWNLDYKRSSITVSPLFQTS
                     QEGVFAIGDAAAYNGKVDLIATGFGEAPTAVNQAINYIYPDRDNRVVHSTSLID"
     gene            8706..9764
                     /locus_tag="VHC05_001429"
     CDS             8706..9764
                     /locus_tag="VHC05_001429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit IIC"
                     /protein_id="HEQ5402726.1"
                     /translation="MTTTDKETFSSFMNKVLAGTAIAIVVALIPNAILATFLKPLLPN
                     MAAAEFLHIVQVFQFFTPIMAGFLIGQQFKFNPMQQLAVGGAAYIGSGAWAYTEVIQK
                     GVATGTFQLRGIGDLINMMITASLAVLAVKYFGNKFGSLTIILLPITIGTGVGYIGWK
                     FLPYVSYVTTLIGQGINSFTTLQPILMSILIAVAFSLIIVSPISTVAIGLAIGLNGMA
                     AGAASMGIASTAAVLVWATLKVNKSGVPIAIALGAMKMMMPNFLKHPIMAIPMVFTAA
                     ISSLTVPLFNLVGTPASSGFGLVGAVGPIASLAGGSSILIIILAWIIVPFAVAFAAHK
                     VSKDILKLYKEDIFVFEG"
     gene            9777..10700
                     /locus_tag="VHC05_001430"
     CDS             9777..10700
                     /locus_tag="VHC05_001430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000964166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-dehydropantoate 2-reductase"
                     /protein_id="HEQ5402727.1"
                     /translation="MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGL
                     IVTGDVEETVKLPIMKSTEATQEADLIILFTKAMQLPQMLQDIKGIIGKETKVLCLLN
                     GLGHEDVIRQYIPEHNILMGVTVWTAGLEGPGRAHLQGVGALNLQSMDPNNQDAGHQV
                     ADLLNKANLNATYDENVVPNIWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEI
                     IHEFVIVGQAEGVELNEEEITQYVMDTSVKAAHHYPSMHQDLVQNHRLTEIDFINGAV
                     NTKGEKLGINTPYCRMITELVHAKEAVLNIQ"
     gene            10956..11669
                     /locus_tag="VHC05_001431"
     CDS             10956..11669
                     /locus_tag="VHC05_001431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEQ5402728.1"
                     /translation="MAKITEENYVSLEDLMQLLNSSESTIRRDLGELEQEGRLHRVHG
                     GAELFHSLQEELSNQEKSVKNSHIKKAIAQRASQLIYDNDVIFIDAGTTTEFLLPFLQ
                     AKNLTVVTNSIHHAARLVELSIETIIVGGYVKQTTDASIGNVALEQIRQMNFDKAFLG
                     MNGVDDSYLTTPDMEEAVIKKAVLSNAKLAYILVDGTKIGQVSFVKVAPINDVTIITL
                     GGSASILKQIKEKAKVIEL"
     gene            11666..12577
                     /gene="pfkB"
                     /locus_tag="VHC05_001432"
     CDS             11666..12577
                     /gene="pfkB"
                     /locus_tag="VHC05_001432"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HEQ5402729.1"
                     /translation="MIYTVTLNPSIDFIVRIDQINLGSVNRMASDDKFAGGKGINVSR
                     ILQRLDIASTATGFLGGFTGRFIEESLSAEGVKTDFVKGDQVTRINVKIKSQEETELN
                     GQGPIISQEQLEELKTKLSQLTAEDTVVFAGSAPANLGNAVYKELLPLVRQSGAQVVC
                     DFEGQTLIDALTYNPLLVKPNNHELEAIFGTILTSLDDVETYARRLLEMGAQNAIISM
                     AGDGALLVTKEATYFAKPIKGEVKNSVGAGDSMVAGFTGEFMKSQNPIEALKWGVACG
                     TATAFSDDLATIAFIKETYHKVEVEKR"
     gene            12574..14520
                     /locus_tag="VHC05_001433"
     CDS             12574..14520
                     /locus_tag="VHC05_001433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEQ5402730.1"
                     /translation="MKIQDLLRKDIMILDLQAISKEVAIDEMITKLVEKDIVHDFDVF
                     KKSIMTREEQTSTGLGDGIAMPHSKNIVVDKPAVLFAKSNKGVDYKALDGQPTDLFFM
                     IAAPQGANDTHLAALAELSQYLLKDGFADKLRAAATPEAVIAVFDEASTAKEEVVAPT
                     SGQDFIVAVTACPTGIAHTYMAEEALKKQAAEMGVAIKVETNGASGVANRLTAEDIQR
                     AKGVIVAADKTVEMDRFDGKQFIARPVADGIKKSQELISLILNNEGNTYHAKNGKSET
                     AVSTEKTSLGGAFYKHLMGGVSQMLPFVIGGGIMIALAFLLDNMLGVPNDQLGSLGSY
                     HEIAAIFMNIGGAVFSFMLPVLAGYIAYSIAEKPGLVAGFVAGAIASNGLAFGKVPFA
                     AGGEVSLGLTGVPSGFLGALVGGFLAGGVILALRKLLAALPRSLEGVKSILLYPLLGV
                     LVTGFLMLFVNIPMAAINTALNDFLQGLSGSSAVLMGLLVGGMMAVDMGGPVNKAAYV
                     FGTGTLAATVANGGSVVMAAVMAGGMVPPLAVFVATLLFKDKFTKEERESGLTNIVMG
                     LSFITEGAIPFGAADPARAIPSFIAGSALTGALVGLAGIKLMAPHGGIFVIALTSNPI
                     LYLVFVVIGALVSGILFGALRKKA"
     gene            14613..15212
                     /locus_tag="VHC05_001434"
     CDS             14613..15212
                     /locus_tag="VHC05_001434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 73 protein"
                     /protein_id="HEQ5402731.1"
                     /translation="MKVKKRRRRAKSSVNRLVLGLVLLNLIVSMWTLKLGNQRLAPYA
                     DHETLTFVRKISHAAQSVAQKKQLYSSVMMAQAILESNNGKSQLSQKPYYNFFGIKGS
                     YKERSVIFPTLEDDGQGNLYQIDATFRSYGSLTACFLDYARVLNDPLYDKTHKKFWSH
                     YQDATATLTGTYATDTTYHTKLNELIEWYQLTNFDGLMK"
     gene            15364..16071
                     /locus_tag="VHC05_001435"
     CDS             15364..16071
                     /locus_tag="VHC05_001435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 73 protein"
                     /protein_id="HEQ5402732.1"
                     /translation="MTKKKGKLVLISLFVLAACLGAYSAMRQSHKTSNVSAETIASSS
                     TRHFIDEIGPTASTIGQERDLYASVMIAQAILESSNGKSSLSQAPYHNFFGIKGAYNG
                     SSVTMSTWEDDGNGNTYTIDQAFRAYPSIADSLNDYADLLSSSTYIGARKSNTLSYQD
                     ATAALTGLYATDTSYNLKLNNIIATYGLTAYDVANSSAQETGLATSGYVWNEYRRNYT
                     DAETLAVDEAWAKRMTY"
     gene            complement(16128..16439)
                     /locus_tag="VHC05_001436"
                     /pseudo
     CDS             complement(16128..16439)
                     /locus_tag="VHC05_001436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611423.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            complement(16643..>16876)
                     /locus_tag="VHC05_001437"
     CDS             complement(16643..>16876)
                     /locus_tag="VHC05_001437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exotoxin"
                     /protein_id="HEQ5402733.1"
                     /translation="DFKIRKFLMESKEIHLTKSPYIRGSLEIHSKNRKDEKINLYDAK
                     PNSTRSDVLKKYKDNKTINMKDFSHFDIYLWTK"
BASE COUNT         5437 a         2703 c         3436 g         5300 t
ORIGIN      
        1 gcttgttgac ttaaagtcaa caagcttttt gaatagcaaa aatcttaata tttctgaaat
       61 gaaaagatta gatttttctg tctttaacta aaaagaagtt aaagaatggc ttagctgatt
      121 gcctttataa gagattatac tggtttttga tagctgctgt catgtaaaat agctacaatt
      181 catcttacga gattgacctt agcattgcca gtgcagtctt tattttccaa cctgctgttt
      241 gttgtatgtt tatagtttcc taaaaaatgc tctctcagtt ttttgggggg gcattcctaa
      301 aattaagtat acttaatttt aggaatgttt atattcttta cattctgatg aaaatacaaa
      361 ttatcctaat atgatgtatt gaaaggggaa atagtttatg ttagtatact gattaagtga
      421 agctgtaatg agacttatac tatcaaaaaa gttagaataa ctttataaaa cagtggtgtt
      481 gaagcaagtt tagcttcttc tcagagatag attatctata aaaaatccta aaagtagttt
      541 gtttccagtt aatgaacttc ttttgggaag gcttttttgc tggtcgccac ctcacttgta
      601 tatcgggaac cttcacgcta agatgtataa gttgaatcgt ttgtctatgg cttgatgaaa
      661 attaatcaaa agataatgtt caactctata attggtacaa gcaaaatgag ataacttatt
      721 cattagtaag cataagatat aacaagagaa attaccttaa aacaggaagt actagagtat
      781 ttaaaataag tgatagactt ggatattatt aggtcgacta gtgttctttt caataattta
      841 atatcgttat tattagtatc agccaatcaa atgtggataa gttggctttt agaaaggttt
      901 taccacaatg aagaaacatc ttaaaacagt tgccttgacc ctcactacag tatcggtagt
      961 cacccacaat caggaagttt ttagtttagt caaagagccg attcttaaac aaactcaagc
     1021 ttcttcatcg atttctggcg ctgactacgc agaaagtagc ggtaaaagca agttaaagat
     1081 taatgaaact tctggccctg ttgatgatac agtcactgac ttattttcgg ataaacgtac
     1141 tactcctgaa aaaataaaag ataatcttgc taaaggtccg agagaacaag agttaaaggc
     1201 agtaacagag aatacagaat cagaaaagca gatcacttct ggatctcaac tagaacaatc
     1261 aaaagagtct ctttctttaa ataaaacagt tttaaataaa acagtgccat caacgtctaa
     1321 ttgggagatt tgtgatttta ttactaaggg gaataccctt gttggtcttt caaaatcagg
     1381 tgttgaaaag ttatctcaaa ctgatcatct cgtattgcct agtcaagcag cagatggaac
     1441 tcaattgata caagtagcta gctttgcttt tactccagat aaaaagacgg caattgcaga
     1501 atataccagt agggctggag aaaatgggga aataagccaa ctagatgtgg atggaaaaga
     1561 aattattaac gaaggtgagg tttttaattc ttatctacta aagaaggtaa caatcccaac
     1621 tggttataaa catattggtc aagatgcttt tgtggacaat aagaatattg ctgaggttaa
     1681 tcttcctgaa agcctcgaga ctatttctga ctatgctttt gctcacctag ctttgaaaca
     1741 gatcgatttg ccagataatt taaaagcgat tggagaatta gctttttttg ataatcaaat
     1801 tacaggtaaa ctttctttgc cacgtcagtt aatgcgatta gcagaacgtg cttttaaatc
     1861 aaaccatatc aaaacaattg agtttagagg aaatagtcta aaagtgatag gggaagctag
     1921 ttttcaagat aatgatctga gtcaactaat gctacctgac ggtcttgaaa aaatagaatc
     1981 agaagctttt acaggaaatc caggagatga tcactacaat aaccgtgttg ttttgtggac
     2041 aaaatctgga aaaaatcctt atggtcttgc tactgaaaat acctatgtta atcctgataa
     2101 gtcactatgg caggaaagtc ctgagattga ttatactaaa tggttagagg aagattttac
     2161 ctatcaaaaa aatagtgtta caggtttttc aaataaaggc ttacaaaaag taaaacgtaa
     2221 taaaaactta gaaattccaa aacagcacaa tggtgttact attactgaaa ttggtgataa
     2281 tgcttttcgc aatgttgatt ttcaaaataa aactttacgt aaatatgatt tggaagaagt
     2341 aaagcttccc tcaactattc ggaaaatagg tgcttttgct tttcaatcta ataacttgaa
     2401 atcttttgaa gcaagtgacg atttagaaga gattaaagag ggagccttta tgaataatcg
     2461 tattgaaacc ttggaattaa aagataaatt agttactatt ggtgatgcgg ctttccatat
     2521 taatcatatt tatgccattg ttcttccaga atctgtacaa gaaatagggc gttcagcatt
     2581 tcggcaaaat ggtgcaaata atcttatttt tatgggaagt aaggttaaga ccataggtga
     2641 gatggcattt ttatcaaata gacttgaaca tctggatctt tctgagcaaa aacagttaac
     2701 agagattcct gttcaagcct tttcagacaa tgccttgaaa gaagtattat taccagcatc
     2761 actgaaaacg attcgagaag aagccttcaa aaagaatcat ttaaaacaac tggaagtggc
     2821 atctgccttg tcccatattg cttttaatgc tttagatgat aatgatggtg atgaacaatt
     2881 tgacaataaa gtggttgtta aaacgcatca taattcctac gcactagcag atggtgagca
     2941 ttttatcgtt gatccagata agttatcttc tacaatggta gaccttgaaa agattttaaa
     3001 actaatcgaa ggtttagatt attctacatt acgtcagact actcaaactc agtttagaga
     3061 catgactact gcaggtaaag cgttgttgtc aaaatctaaa ctccgacaag gagaaaaaca
     3121 aaaattcctt caagaagcac aatttttcct tggccgcgtt gatttggata aagccatagc
     3181 taaagctgag aaggctttag tgaccaagaa ggcaacaaag aatggtcagt tgcttggaag
     3241 gagtattaac aaagcggtat tagcttataa taatagcgct attaaaaaag ctaatgttaa
     3301 gcgcttggaa aaagagttag acttgctaac aggattagtt gagggaaaag gaccattagc
     3361 gcaagctaca atggtacaag gagtttattt attaaagacg cctttgccat tgccagaata
     3421 ttatatcgga ttgaacgttt attttgacaa gtctggaaaa ttgatttatg cacttgatat
     3481 gagtgatact attggcgagg gacaaaaaga cgcttatggt aatcctatat taaatgttga
     3541 cgaggataat gaaggttatc attccttggc agttgccact ttagctgatt atgaggggct
     3601 cgacatcaaa acaattttaa atagtaagct tagtcaatta acgtctattc gtcaggtacc
     3661 gactgcagcc tatcatagag ccggtatttt ccaagctatc caaaatgcag cggcagaagc
     3721 agaacagtta ttgcctaaac caggtacgca ctctgagaaa tcaagctcaa gtgaatctgc
     3781 taactctaaa gatagaggat tgcaatcaaa cccaaaaacg aatagaggac gacactctgc
     3841 aatattgcct aggacagggt caaaaggcag ctttgtctat ggaatcttag gttacactag
     3901 cgttgcttta ctgtcactaa taactgctat aaaaaagaaa aaatattaaa ttgatttaag
     3961 gagaaaaaat gataacacaa gaaatgaaag atcttattaa taaccaatta gcaatggttg
     4021 cgacggttga tgccaaaggt caacccaata ttggtccaaa acgttctatg cgtctctggg
     4081 atgataaaac atttatttat aatgaaaata cagatggtca aactcgtatt aacattgaag
     4141 ataatgggaa aattgaaatt gcctttgttg atcgtgagcg ccttttaggt tacaggtttg
     4201 taggaactgc tgaaattcaa acagaaggtg cttattacga agcagcgaaa aaatgggcac
     4261 aaggacgcat gggggtacca aaagcagttg gtattattca tgtcgagcgt atttttaatt
     4321 tacaatctgg tgctaatgca ggtaaagaaa taaacagtga aagtaactaa aattaactgt
     4381 aacagtattt aggaccctta ttttaaacgc taaaaaacaa gcatactctt ttttacagca
     4441 tagtgactat gttgtaaaaa ggggtatgct tattaggtgc tcttaatatt tctagataac
     4501 tgcacctaat aagttttcaa tagacttata gcacattagt tgacttcaat tagttgactt
     4561 caataccaga aagagaagaa cagtgatgtt ggtgttcgtt taaagaagta tcgatttcca
     4621 cagtgactga gtttatattg tacctttgac aaatcagtct aatagatttt ttgcaatgtt
     4681 tttcagtggt agattctctc aagcagcaat gtatagttgc tctatggtca ataccatcca
     4741 tcgaccaaac attaagctga ttaacagaca ctatatgagg aagttggctg agttcatggt
     4801 gcaaagcgca atagtctatc gaatcaggaa caccatctaa aaaaatgtta gcggttgcta
     4861 ctaactttgg aagagcttta gataatataa aagaagcaat ggcaattgat aataaaggat
     4921 caagaatgta ccaaggtttc cattttaaga tcagtgacaa tatgataatg gctaaccacc
     4981 caaggatatc ttctaaaaag tgaaggctta atatttcttc attttttgtc tggttagagt
     5041 gaatgatgaa gctagcaaat ccattgatta taattgcaaa aatagctaaa acgaacatac
     5101 cgtcataatt aacaatagta ggatgccata attttggtat cgtttcaatc attactaata
     5161 atgacccgct aataagtatt agatttgttg ttagtgctcc taaaaggcta aatcgcttat
     5221 agcctagtga aaaatttgga ctctcttttt taacagcctt tctttctaag atagctgaga
     5281 taccaatagc aatggcatct ccaaaatcgt ggacagcatc tgctaaaata gcacccgaaa
     5341 agaataatgt tccaaaaata aattcaatga gggaaaaact aagatttaat ataaaaataa
     5401 tggtgacttt tttacttgct ggcataattt tctccttttg ttatactggt aatatgtata
     5461 gtagaattct ttattctatt atctagaagt taaaatacaa ttactataac caaaaatgag
     5521 cacctgttca atagtgaaca acatttagaa agtgtccgat atgacaaaag acagacaaat
     5581 caaaaaaaca aaaacagcta tctatagtgc ttttattgct ttattacaaa aaaaagaata
     5641 ttcgaaaata actgttcgag atatgattac acttgctaat gtagggagat caacctttta
     5701 tgcacattat gaaagcaaag aaatgttact aaaagaactc tgtgaagaac tttttcatca
     5761 tttgtttagg caaaaaagaa atgtgacttt tgaagactat ttggtacata ttttaaagca
     5821 ttttgaacaa aataaagaca gcattgcgac gttgttactt tctaatgatc cctatttttt
     5881 attaagattt aaaaacgaac tagaacatga tgtttaccct aacttgcgct gcaagtatat
     5941 cgacaaaacg actattccag aagtattcct gaaacaattt gttctatcta gttttgtaga
     6001 aaccttaaaa tggtggctcc atcaaaggca aaggatgtct gcaaatgaac tattaaagta
     6061 ttatttagag ctcataaaat aatgactagt gagtcatctt gccaaattca attttttaat
     6121 acagacgtat tttaacaatt taacagagaa agacaaaact gtaagtgcaa aatagactat
     6181 aacgtgataa aataataggt aatttggttc tgaaaaagaa gtgtctatca aactttagaa
     6241 tcaagagagg tcgctaaagt gacgtgagat aaagagttaa cgatttagga gctaccatgg
     6301 aatattttaa tgttggaaaa attgtcaaca cgcaaggcct gcaaggagag atgcgcgtgt
     6361 tgtctgtcag tgattttgct gaggaacgct ttaaaaaagg ctcacaatta gctttatttg
     6421 atgataaaga tcggtttgtt caagaagtga caattgttag tcaccgtaaa caaaagcatt
     6481 ttgatattat caaattgaaa gacatgtatc atattaatgc tattgaaaag tacaagggat
     6541 acactttaaa ggtctcaaaa gacaatcaag gagatttaca agaaggagaa ttttattacc
     6601 atcagattat tggcatggct gtttatgaaa aggaccggtt gattggctat gtcaaggaaa
     6661 tcttgcagcc aggtgctaat gatgtttggg tagtgaaacg ccaaggaaaa cgagacttgc
     6721 tcttaccata tattccccca gtagttctta acgtagatgt tcctaacaag cgcgtggatg
     6781 ttgaattgat ggaaggctta gacgatgaag attgatattt taaccctttt tcctgaaatg
     6841 tttgctcccc tagaacattc cattgtaggc aaggcaaaag aaaaaggtct gttagacatt
     6901 cactaccata actttcgaga ttatgctgaa aaagctcgtc atgtggatga cgaaccctat
     6961 ggtgggggcc aaggcatgtt attgagagcg cagcccattt ttgacaccat tgaacagatt
     7021 gaagccaaaa aaccaaggat tattctttta gatccagcag gtaaaccctt tactcaggct
     7081 tatgctgaag aattagctct tgaggaagag ttaattttta tttgtggtca ttatgaaggt
     7141 tatgatgagc ggattaagac cttggtgacg gatgaaattt cattaggtga ctttgtatta
     7201 acaggaggtg agttggcggc catgactata gtggatgcga ccgtcaggtt aattccacag
     7261 gtacttggga aagaaagtag ccatcaggac gattcttttt catcaggact tttagaatac
     7321 cctcaataca caagacctta tgattatcgt ggtatgacag ttccagatgt tctaatgagt
     7381 ggtcatcacg aacgtattcg cttgtggcgt ctagaagaaa gtctcagaaa aacctatttg
     7441 agaaggccag atttgttaga gcggtacgat ttttccgagg aagagcgcaa gctattggat
     7501 aagattaaag aagcattggg ttaaggagaa gattagtgaa agataaagca tatgatatta
     7561 cgattattgg tggtggtcca ataggtttat ttgcagcctt ttatgcaggt cttaggggcg
     7621 taacagtaaa gattattgag agtttgtcag aacttggtgg acagcctgcc attctttatc
     7681 ctgagaaaat gatttatgat attccagctt atccatcttt aacaggtgtt gagttgacag
     7741 aaaatttaat aaaacaatta agccgttttg aagatcgtac aaccatttgt ttaaaagaag
     7801 aagtattaac ctttgacaag gttaaaggtg gtttttcgat taggactaat aaggcagagc
     7861 atttttcaaa agccattatc attgcttgtg gaaatggcgc ttttgcacca agaactttag
     7921 ggttagaaag tgaggaaaac tttgctgatc ataacctttt ttataatgtt caccagttgg
     7981 accagtttgc gggacaaaaa gttgtgattt gtggtggtgg agattcagca gttgattggg
     8041 ctttggcttt agaagatatt gctgagagtg tgacggttgt gcaccgtcgt gatgctttca
     8101 gagcacatga acacagtgtg gaattattga aagcatcaac ggtcaacctc ttaacacctt
     8161 atgtgccaaa agcattgaaa ggaattggaa acctggctga aaaattagtt attcaaaaag
     8221 tgaaagaaga tgaagtgtta gaacttgaat tggacagtct tattgttagt tttggttttt
     8281 caacttctaa taagaatttg aaaaattgga atctcgacta taagcgttca agtattactg
     8341 tttcaccact ttttcaaaca agtcaagaag gtgtttttgc cattggtgat gcagccgctt
     8401 ataatgggaa agtggatttg attgctactg gttttggcga agcaccaaca gcagttaatc
     8461 aggctattaa ctatatttat ccagatcgag ataaccgtgt ggtgcattca acctctttaa
     8521 ttgactaagg gagtcggaag tttcaagagc agtagcaaca gctaatattc agtttgtcag
     8581 gataggacaa atggttttta cctaagtctt cgtgacaagt tttatacttt gtgataaaat
     8641 agtcattgtg aaaaaagtgt gatggttttc acagattaac acattacaat gaaaaggggt
     8701 ctatcatgac aacaacagat aaagagacat ttagttcttt tatgaataag gtcttggctg
     8761 gtacagcgat tgctatcgtt gtggcactca ttccaaatgc tattttagcg actttcttaa
     8821 aaccgctttt gccaaatatg gcagctgctg aatttttaca cattgtgcaa gtcttccaat
     8881 tcttcacgcc gattatggct ggtttcttga ttgggcaaca atttaagttt aatcctatgc
     8941 aacagttggc tgttggtgga gctgcttata tcggttctgg agcctgggct tatacagaag
     9001 tcattcaaaa aggtgtggcg acaggaacat tccaacttag aggtattggg gacttaatca
     9061 atatgatgat tacagctagc cttgcggttt tagctgtgaa atattttggg aataaatttg
     9121 gctctttaac cattatcttg ttacctatca ctataggaac tggcgtaggt tatattggtt
     9181 ggaaattttt gccttatgtg tcttacgtga caaccctgat cggacaaggg attaattctt
     9241 ttacaacctt acaacctatt ttaatgtcta ttttaattgc agttgctttc tcgcttatca
     9301 ttgttagtcc gatttcaact gttgcaatcg gtttagctat tgggcttaat ggaatggctg
     9361 cgggagcagc ttctatggga attgcatcga cagcagcagt cttagtgtgg gcgacgctta
     9421 aagttaataa atctggtgta ccaattgcta tcgcacttgg ggctatgaaa atgatgatgc
     9481 caaacttctt gaaacatcct atcatggcta ttccgatggt gttcactgca gcaattagct
     9541 cattaacagt accattgttt aatcttgttg gaacaccagc ttcatctggt tttggcttag
     9601 ttggtgcagt aggtccgatt gcttctttag caggtggtag ctcaatactt attattatcc
     9661 ttgcttggat cattgttccg tttgcggttg cttttgcggc gcataaggtt tctaaagata
     9721 ttctaaaact ttataaagaa gacattttcg tctttgaagg ctaataggag gaaaatatgt
     9781 tagtttatat tgctggctca ggagccatgg ggtgccgttt tggttaccaa atttcaaaaa
     9841 caaataacga tgtgattttg ttagataact gggaagatca tatcaatgcc attaaagaaa
     9901 acgggttgat tgtaacaggt gatgtggaag aaacagttaa gcttcctatt atgaaatcga
     9961 ctgaagccac tcaagaagcc gatttgatta tcttgtttac aaaagcaatg cagttgccac
    10021 aaatgcttca agacattaaa ggcattattg gaaaagaaac caaagtgctt tgccttttaa
    10081 atggtcttgg acacgaagac gttattcgtc agtacattcc agagcacaac attttgatgg
    10141 gggtcactgt ctggactgct ggtctagaag gaccaggtcg tgctcatctt caaggagttg
    10201 gtgctcttaa cttacaaagt atggatccaa acaatcaaga tgcgggacat caagtggctg
    10261 acttgctaaa taaagctaac ttaaatgcga cttatgatga gaatgttgtg ccaaacatct
    10321 ggcgaaaagc ttgcgtgaat ggtaccatga attcgacttg tgctctttta gattgtacga
    10381 ttggcgaatt atttgccagt gaagatggtc tcaaaatggt aaaagaaatc atccatgagt
    10441 ttgttatcgt tggtcaagca gaaggtgtcg aactaaacga agaagaaatc acacaatatg
    10501 taatggatac atctgttaaa gctgctcacc attacccatc aatgcaccaa gaccttgtgc
    10561 aaaatcaccg attgactgaa attgatttta tcaatggtgc agtcaatacc aaaggtgaaa
    10621 agcttggtat caatactcca tactgccgta tgattacaga gctagttcac gctaaagaag
    10681 cagtgttgaa catccaataa acgctatcaa atcgttacac tcaatattat ggctaaagct
    10741 ttaatattga gttttttgtt atgctgatag tatttttctt aggcatcatt atttgtgagc
    10801 ctagattatg agttaataaa agaaataata attggtagaa tttgatagat tttgaaaggt
    10861 tatgcttgac ttttagttat aaaatagtat aataattgta aacgatttca gttaggggtg
    10921 gttctatctt aaaatcaaaa cgaaaacaat taatcatggc aaagatcact gaagaaaact
    10981 atgtttcttt agaggattta atgcaattac tcaactcctc tgagtctact atccgtagag
    11041 atctaggaga gttggagcaa gaaggacggc tacatcgtgt tcatggaggt gctgaacttt
    11101 ttcactcttt acaagaggaa ctttcgaacc aagaaaagtc tgtcaaaaac agtcatatta
    11161 aaaaagctat tgcgcaaaga gcctctcagc ttatctatga caacgatgtg atctttattg
    11221 atgctgggac aacgactgaa tttttattac cttttttaca agctaaaaat ttaactgtag
    11281 ttactaattc tattcatcat gctgctagat tagttgaact ctctattgag acgattattg
    11341 tagggggtta tgtcaaacaa acgaccgatg ctagtattgg taatgtagct ttggaacaga
    11401 ttaggcagat gaattttgac aaggcatttc ttggaatgaa tggtgttgat gattcttacc
    11461 tgacgactcc tgatatggaa gaagcagtta ttaaaaaagc ggttctgtca aatgcaaaat
    11521 tagcttacat tttagtagat ggcactaaaa ttggtcaggt atcgtttgta aaagtagctc
    11581 ctattaatga tgtgactatt attacattag gaggatcagc aagtattctt aaacaaataa
    11641 aggaaaaggc aaaggtgatt gaattatgat ttataccgtg accttaaacc cttctattga
    11701 ctttattgtc agaattgacc aaataaatct tgggtcagtg aatcgcatgg cgagtgatga
    11761 taagtttgct ggaggtaaag gcattaatgt gagtcgcatc ttgcaacgtt tagacattgc
    11821 tagcacggcg acagggttct tgggtggttt tacaggacgt tttatcgaag aaagtttgag
    11881 tgcagaaggc gttaaaactg attttgtaaa aggtgatcaa gttactcgaa tcaatgttaa
    11941 aatcaagtca caagaagaga ccgaattaaa tggtcaagga cctatcatta gtcaggaaca
    12001 actagaggag ttgaaaacta agctttccca gctaacagca gaggatacag ttgtctttgc
    12061 aggttcagcg ccagctaatc ttggcaatgc tgtttataag gaattacttc ctttagttag
    12121 gcaaagcggt gctcaggtgg tttgtgattt tgaaggacag actttaatag atgcgcttac
    12181 atataatcct ctgttggtta aacctaataa tcatgaacta gaagctattt ttggtacgat
    12241 tctgactagt cttgatgatg ttgaaaccta tgcccgtcgt cttttagaga tgggtgctca
    12301 aaatgccatc atttcaatgg ctggtgatgg tgctttgctg gttactaaag aagcgactta
    12361 ttttgctaaa ccgattaagg gagaagttaa aaattctgtc ggtgctggtg attcgatggt
    12421 tgctggcttt acaggcgaat ttatgaagag tcaaaatcca atagaagcct taaaatgggg
    12481 cgtggcttgt ggtacagcga cggctttctc tgatgacttg gcgacaattg catttattaa
    12541 ggaaacatat cataaagttg aggtagaaaa acgatgaaaa ttcaagattt attgagaaaa
    12601 gatattatga ttctcgattt acaggctatt tctaaagaag ttgccattga cgagatgatt
    12661 actaaattag ttgaaaaaga tattgtacat gattttgatg tctttaaaaa gagtatcatg
    12721 acacgtgaag aacaaacatc aacagggctt ggtgatggga ttgccatgcc tcattctaaa
    12781 aatattgtag tagataaacc agcggtcttg tttgcgaaat caaataaagg cgtggattat
    12841 aaggctttag atggtcaacc aacggatctc ttctttatga ttgctgcgcc tcaaggagca
    12901 aatgatactc acttggctgc gctagcagaa ttatcacaat accttttgaa agacggcttt
    12961 gctgataaac ttcgtgctgc agcgacacca gaagcagtca ttgctgtttt tgatgaagcg
    13021 tcaacagcta aagaagaagt ggttgctcca acaagtggtc aagactttat cgttgctgtt
    13081 acagcttgtc cgacaggaat tgctcacact tatatggcag aagaggcttt gaaaaaacaa
    13141 gctgcagaaa tgggagtagc tattaaagtt gaaacaaacg gtgcttctgg tgtggctaat
    13201 cgtttaaccg ctgaagatat tcagagagct aaaggagtta ttgttgcagc tgataaaacg
    13261 gttgaaatgg accgttttga tggtaaacaa ttcattgctc gccctgttgc agatggtatc
    13321 aagaaaagtc aggaattgat ttctttgatt ttaaacaatg aaggaaacac ttatcatgct
    13381 aaaaatggaa aatctgaaac agcagtatca actgagaaaa caagtttagg cggtgctttc
    13441 tataaacact tgatgggcgg tgtctcacaa atgttgccat ttgttattgg tggcgggatt
    13501 atgattgctc tagcattttt attggataac atgcttggtg tgccaaatga tcagcttgga
    13561 agtcttggat cctatcatga aatagcagct atttttatga acattggtgg agcagtcttt
    13621 tccttcatgt taccagtact agcaggttat atcgcttatt ctattgctga aaaaccgggc
    13681 ttagtagctg gttttgtggc aggtgccatt gcctcaaatg gtcttgcttt tggtaaggta
    13741 ccatttgcag caggaggaga agtgagcttg ggcttaacag gcgtgccatc aggtttcctt
    13801 ggggcgcttg tgggtggttt ccttgccggt ggtgttattc ttgcccttcg taaattgttg
    13861 gcagccctac cacgttctct agaaggggtt aaatctatcc tcctttaccc attacttggc
    13921 gtccttgtca ctggtttctt gatgcttttt gtcaatattc caatggcagc tattaacaca
    13981 gctcttaatg atttcttaca aggtctttca ggaagctctg ctgtccttat gggacttctt
    14041 gttggtggaa tgatggctgt tgacatgggt ggtcctgtta ataaggcagc ttatgttttt
    14101 ggtacaggaa ctttagcagc tactgtggca aatggtggtt cggtcgttat ggccgctgtt
    14161 atggcaggtg gtatggtacc tcctcttgct gtttttgtag ccactctctt gtttaaagat
    14221 aaatttacca aagaagaacg tgaatcaggc ttgacaaata ttgttatggg actttcattc
    14281 atcaccgaag gagcaattcc gtttggtgca gctgacccag cacgtgcgat tcctagcttt
    14341 atcgcaggtt ctgccttgac aggagctctt gttggtttgg ctggtattaa attaatggcg
    14401 ccacatggtg gtatcttcgt aattgcttta acaagcaatc caatcttata tcttgtcttt
    14461 gttgtgattg gtgcccttgt atcaggtatc ttatttggcg ctcttcgcaa aaaagcctaa
    14521 aaggtaaaga acttttttct tactaaaact agaatctgtc aaggttctag ttttttgcta
    14581 tactagagtt aaaggataag aaatgaggac ctctgaaggt gaaaaaaagg agaagaaggg
    14641 ctaaatcatc cgtaaatcga cttgtcttag ggttagtatt acttaatctg attgttagta
    14701 tgtggacatt aaaattggga aaccagcgat tagctccgta tgcggatcac gaaactctga
    14761 catttgtcag gaagattagt catgctgctc aatcagtcgc tcaaaagaaa cagttataca
    14821 gttcggtgat gatggctcag gccattttag aatccaataa tggcaagtca caactaagtc
    14881 aaaaacctta ttataatttt ttcgggatta aggggagcta taaagaacgg tcagtcattt
    14941 ttccaacttt agaagacgat ggacaaggga atctttatca aattgatgct acttttcgtt
    15001 cctatgggag cctgacagct tgttttttag attacgcaag agttttgaat gatccacttt
    15061 atgacaaaac ccacaaaaag ttttggtctc attatcaaga tgctactgca accttaacag
    15121 gcacttacgc cactgataca acttaccata ccaaattaaa tgaattgatt gaatggtatc
    15181 aactcactaa ttttgatggt ctaatgaaat agttatccac aattttaaaa aaaatcagaa
    15241 gaaatatgtc gatttcaaga caaaagttat caatctcatt aaattatctg tggaaaagtt
    15301 aatttaaacg ttcgtgtgct ataatagaaa catagaaaat gtataaaaaa ggatatgtga
    15361 ataatgacaa aaaagaaagg taagcttgta cttatcagtc tttttgttct agcagcttgt
    15421 ttaggagctt atagtgcaat gagacaatct cataaaactt caaacgtgtc agctgagact
    15481 atcgccagtt cttcaacccg acattttatt gatgaaattg gtccaactgc tagtactatt
    15541 ggtcaagaac gtgatcttta tgcgtctgtt atgatagcac aagcgatttt agaatcaagt
    15601 aatggtaaat caagtctaag tcaagctccc tatcataact tctttggcat caaaggggcc
    15661 tataatggtt cgtcagttac catgtcaact tgggaagatg atggtaatgg caatacctat
    15721 acgattgatc aagcctttag agcttatcca agtattgcag actcccttaa tgactatgcg
    15781 gacttgctaa gttctagcac ttatataggt gctagaaaat caaacacgct atcgtatcaa
    15841 gatgctacag cagctctaac tggcttatac gctacagaca ccagttataa cttaaaacta
    15901 aataatatta ttgcaaccta tggtttgacg gcttatgatg ttgctaatag ctcagctcaa
    15961 gaaactggtc tagcaacttc gggttatgtt tggaatgagt atcgtcgtaa ttacactgat
    16021 gcggagaccc tagcagttga tgaggcttgg gctaaacgca tgacttatta atgtaacact
    16081 aacaacaatc tgcttgcact gaccccaaaa aagctggata ctctatttta agtaaaggat
    16141 ttagttttgt attggacagg actaaatcct tttagttttg ctttgatatg tttatcgttg
    16201 taataatcaa tgccgtttgt aatcgcttgt tctaagtctt ctagtgattt atagttattc
    16261 tcataaccat agaacatttc tgactttaag atgccaaaga aagattccat catgccattg
    16321 tcaggactgt ttcttttacg tgacatagac ggacgaattc ctttagagtt taggaaatga
    16381 tgataatagt tgtgttgata ttgccaacct tgatcactct atcatatagt tccatcatag
    16441 catttatttg gagatgtctt tttccattat tggtttaatg tgatttaagc aaggttatta
    16501 gctaaactta atgccagaca aaaacacccc aattattaga ttttttgtct aacttttggg
    16561 gcgcaattca atctgagcag ttttagattt ggtatcaatg ttattatagg tcaattgatc
    16621 atatttatcc aaagctttta gcttatttag tccaaagata aatatcaaaa tggctgaaat
    16681 ctttcatgtt tatagtctta ttgtctttat atttttttaa gacatcagat ctggtgctat
    16741 tgggttttgc gtcatataaa ttgatttttt catctttcct atttttactg tgaatttcta
    16801 aactccccct tatataagga gacttagtca aatgaatttc ttttgattcc atcaaaaatt
    16861 ttcttatttt aaaatc
//
LOCUS       DAUDWO010000041        16290 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.042, whole genome shotgun sequence.
ACCESSION   DAUDWO010000041 DAUDWO010000000
VERSION     DAUDWO010000041.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 16290)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16290)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16290
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.042"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(<1..501)
                     /locus_tag="VHC05_001438"
     CDS             complement(<1..501)
                     /locus_tag="VHC05_001438"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402734.1"
                     /translation="MLKLTPPCFSVKDILDELLDGVTKSKEFTDDQGNRIDSKKYTEL
                     FNDSVKNRIFEFEVIYIKLAESGTLHSLRQSDCRVSEEIGKEEMEFLYKQKLVTKYKD
                     SYYLRLRTNENKNFNQCVYCERDLVSDLDHLLPQSEFPIFAVTPANLIPSCHICNKNK
                     SANLSDV"
     gene            complement(494..2029)
                     /locus_tag="VHC05_001439"
     CDS             complement(494..2029)
                     /locus_tag="VHC05_001439"
                     /inference="COORDINATES: protein motif:HMM:NF012235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HEQ5402735.1"
                     /translation="MTFKVVETYWDIQNDGYYLVHSNWDDWFKYETTYLFYIKKNNQT
                     TNVGSIKIGQFSMVEGQRVPNLPEEFDSLTDDFFSVATDESFYYEINRLESEKREYIL
                     TALKDVAFDNDLYHKAVKTDVFNVSLTRDLLPQVIVNKYRRLANGNTKLSNYDFSFKM
                     SDACTLNFKVSPTEFPASNIHAIIGRNGVGKSYLLTEMVESAIQNDGRFSFNTEFDDN
                     FFSNIISVNFSSFENKKLFEENHEASKGYLYYHLSNRTTAKESKNYKLYKEEDGEIVE
                     YVPEGWDAVFIESVSTALRKKPKLWRDCIKILYSDPIFSQIGIDTLVETFQQEDDIRK
                     FYKEAYKIFRGLSSGHKIVILTITKLVEMVSEKTLVILDEPELHLHPPLLSSFIRSLS
                     QLLIKANGVAILATHSPIILQEVQKECVYKLSREMSTDFMQAVRPSNETFAEDIGSLT
                     FDIFELEAIESGFYTLINQIVKENLSFEDSLQRFDGRMGTLGYKLLLTEILKRDKEEG
                     RNA"
     gene            complement(2032..3129)
                     /gene="purK"
                     /locus_tag="VHC05_001440"
     CDS             complement(2032..3129)
                     /gene="purK"
                     /locus_tag="VHC05_001440"
                     /EC_number="6.3.4.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001084009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide
                     synthase"
                     /protein_id="HEQ5402736.1"
                     /translation="MNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDCPASRV
                     SEVIVAPYDDVEALGQLAARCDVLTYEFENVDADGLDAVVSACQLPQGTDLLRISQNR
                     IVEKDFLANKAGVTVAPYKVMTSSLDLGGLDLTKTYVLKTATGGYDGHGQKIIRSAED
                     LPEAQQLANSAQCVLEEFVNFDLEISVIVSGNGEDVTVFPVQENIHCNNILSKTIVPA
                     RISDQLADKAKKMAVQIAKKLQLSGTLCVEMFATADDIIVNEIAPRPHNSGHYSIEAC
                     DFSQFDTHILGVLGAPLPTIHLHAPAVMLNVLGQHVQQAIDYVTENPSAHLHMYGKLE
                     AKHNRKMGHVTVLKEDEVEFGEEINWKYGEI"
     gene            complement(3116..3607)
                     /gene="purE"
                     /locus_tag="VHC05_001441"
     CDS             complement(3116..3607)
                     /gene="purE"
                     /locus_tag="VHC05_001441"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001875905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HEQ5402737.1"
                     /translation="MKTPIISIIMGSKSDWATMQKTAEVLDNFGIAYEKKVVSAHRTP
                     DLMFKYAEEARGRGIKIIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGLDSLYS
                     IVQMPGGVPVATMAIGEAGATNAALTALRILSIEDQNLADALAHFHEEQGKIAEESSG
                     ELI"
     gene            complement(3885..5150)
                     /gene="purD"
                     /locus_tag="VHC05_001442"
     CDS             complement(3885..5150)
                     /gene="purD"
                     /locus_tag="VHC05_001442"
                     /EC_number="6.3.4.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016502383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HEQ5402738.1"
                     /translation="MKLLVVGSGGREHAIAKKLLASKGVDQVFVAPGNDGMTLDGLDL
                     VNIVVSEHSRLIAFAKENEISWAFIGPDDALAAGIVDDFNSAGLRAFGPTKAAAELEW
                     SKDFAKEIMVKYNVPTAAYGTFSDFEKAKAYIEEQGAPIVVKADGLALGKGVVVAETV
                     EQAVEAAQEMLLDNKFGDSGARVVIEEFLDGEEFSLFAFVNGDKFYIMPTAQDHKRAF
                     DGDKGPNTGGMGAYAPVPHLPQSVVDTAVETIVRPVLEGMVAEGRPYLGVLYVGLILT
                     ADGPKVIEFNSRFGDPETQIILPRLTSDFAQNIDDIMMGIEPYITWQNDGVTLGVVVA
                     SEGYPLDYEKGVPLPEKTDGDIITYYAGAKFAENSKALLSNGGRVYMLVTTEDSVKAG
                     QDKIYTQLAQQDPTGLFYRNDIGSKAIRE"
     gene            5403..6526
                     /locus_tag="VHC05_001443"
                     /pseudo
     CDS             5403..6526
                     /locus_tag="VHC05_001443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054094.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
     gene            complement(6585..8132)
                     /gene="purH"
                     /locus_tag="VHC05_001444"
     CDS             complement(6585..8132)
                     /gene="purH"
                     /locus_tag="VHC05_001444"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006146083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HEQ5402739.1"
                     /translation="MTKRALISVSDKSGIIDFAKELKNLGWDIISTGGTKVALDNAGV
                     ETIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDVDSHLQAAKDNNIELIDLVVINL
                     YPFKETILRPDVTYDLAVENIDIGGPSMLRSAAKNHASVTVVVDPADYATVLGELADA
                     GQTTFETRQRLAAKVFRHTAAYDALIAEYFTAQVGEAKPEKLTITYDLKQAMRYGENP
                     QQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDRPTVIALKHM
                     NPCGIGQADDIETAWDYAYEADPVSIFGGIVVLNREVDAATAKKMHPIFLEIIIAPSY
                     SEEALAILTNKKKNLRILELPFDAQAASEVEAEYTGVVGGLLVQNQDVVAENPSDWQV
                     VTDRQPTEQEATALEFAWKAIKYVKSNGIIITNDHMTLGLGAGQTNRVGSVKIAIEQA
                     KDHLDGAVLASDAFFPFADNIEEVAAAGVKAIIQPGGSVRDQDSIDAANKHGLTMIFT
                     GVRHFRH"
     gene            complement(8316..8870)
                     /gene="purN"
                     /locus_tag="VHC05_001445"
     CDS             complement(8316..8870)
                     /gene="purN"
                     /locus_tag="VHC05_001445"
                     /EC_number="2.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="HEQ5402740.1"
                     /translation="MKIAVFASGNGSNFQVIAEQFLVSFVFSDHRDAYVLERAQNLAI
                     PSFAFELKEFENKAAYEQAIVDLLDKHEIDLVCLAGYMKIVGETLLLAYEGRIINIHP
                     AYLPEFPGAHGIEDAWEAGVDQSGVTIHWVDSGVDTGQVIQQVRVPRLADDSLESFET
                     RIHETEYQLYPAVLDSLGVERKVI"
     gene            complement(9038..10060)
                     /locus_tag="VHC05_001446"
     CDS             complement(9038..10060)
                     /locus_tag="VHC05_001446"
                     /EC_number="6.3.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016480156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="HEQ5402741.1"
                     /translation="MSEKNAYAKSGVDVEAGYEVVERIKKHVARTERAGVMGVLGGFG
                     GMFDLSKTGVKEPVLVSGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPL
                     YFLDYVATGKNNPVKLEEVVSGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAV
                     GVAEKSQIIDGSKVKEGDILLGLASSGIHSNGYSLVRRVFADYTGKELLPELEGKQLK
                     DVLLEPTRIYVKAALPLIKEELVNGIGHITGGGFIENIPRMFADDLAAEIDEDKVPVL
                     PIFKALEKYGDIKHEEMFEIFNMGVGLMLAVSPENVNRVKELLDEPVYEIGRIIKKAD
                     DSVVIK"
     gene            complement(10088..11542)
                     /locus_tag="VHC05_001447"
     CDS             complement(10088..11542)
                     /locus_tag="VHC05_001447"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016480155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HEQ5402742.1"
                     /translation="MTYEVKSLNEECGVFGIWGHPQAAQVTYFGLHSLQHRGQEGAGI
                     VSNDNGKLYGYRNVGLLSEVFKNQSELDNLTGNAAIGHVRYATAGSADIRNIQPFLYK
                     FHDGQFALCHNGNLTNAISLRKELEKQGAIFNASSDTEILMHLIRRSHNSNFMGKVKE
                     ALNTVKGGFAYLLMTENKLIAALDPNAFRPLSIGQMQNGAWVISSETCAFEVVGAKWV
                     RDVEPGEVILIDDSGIQCDRYTDETQLAICSMEYVYFARPDSTIHGVNVHTARKNMGK
                     RLAQEFKQDADIVIGVPNSSLSAAMGFAEESGLPNEMGLVKNQYTQRTFIQPTQELRE
                     QGVRMKLSAVSGVVKGKRVVMIDDSIVRGTTSRRIVGLLREAGASEVHVAIASPELKY
                     PCFYGIDIQTRRELISANHAVDEVCDIIGADSLTYLSLDGLIESIGLETKAPNGGLCV
                     AYFDGHYPTPLYDYEEEYLRSLEEKTSFYIQKVK"
     gene            complement(11703..15428)
                     /locus_tag="VHC05_001448"
     CDS             complement(11703..15428)
                     /locus_tag="VHC05_001448"
                     /EC_number="6.3.5.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase"
                     /protein_id="HEQ5402743.1"
                     /translation="MNKRIFVEKKADFGIKSASLVKELTHNLQLTSLKDLRIVQVYDV
                     FNLAEDLLARAEKHIFSEQVTDRLLTEAEITSELDKVAFFAIEALPGQFDQRAASSQE
                     ALLLFGSDSQVKVNTAQLYLVNKDIAEAELEAVKNYLLNPVDSRFKDITLPLEEQAFS
                     VSDKTIPNLDFFENYKADDFAAYKADQGLAMEVDDLLFIQDYFKSIGRVPTETELKVL
                     DTYWSDHCRHTTFETELKNIDFSASKFQKQLQTTYDKYIAMRDELGRSEKPQTLMDMA
                     TIFGRYERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPF
                     GGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITTPIAETRAGKFPQQVISKTAAHGY
                     SSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKENVVREKPEAGDVVILLGGK
                     TGRDGVGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRDGEVTRLIKKSNDF
                     GAGGVCVAIGELADGLEIDLDKVPIKYQGLNGTEIAISESQERMSVVVRPSDVDAFIA
                     ACNKENIDAVVVATVTEKPNLVMTWNGETIVDLERRFLDTNGVRVVIDAKVVDKDLTV
                     PEARTTSAETLEADTLKVLSDLNHASQKGLQTIFDSSVGRSTVNHPIGGRYQITPTES
                     SVQKLPVQHGVTRTVSVMAQGYNPYIAEWSPYHGAAYAVIEATARLVATGADWSRARF
                     SYQEYFERMDKQAERFGQPVSALLGSIEAQIQLGLPSIGGKDSMSGTFEDLTVPPTLV
                     AFGVTTADSRKILSPEFKAAGENIYYIPGQAISEDIDFDLIKANFSQFEAIQAQHKIT
                     AASAAKYGGVLESLALMTFGNRIGASVEIAELDSSLTAQLGGFVFTSAEEIADAVKIG
                     QTQADFTVTVNGNDLAGASLLAAFEGKFEEVYPTEFEQADALEEVPAVVSDTVIKAKE
                     TIEKPVVYIPVFPGTNSEYDSAKAFEQVGASVNLVPFVTLNEIAIAESVDTMVANIAK
                     ANIIFFAGGFSAADEPDGSAKFIVNILLNEKVRAAIDSFIEKGGLIIGICNGFQALVK
                     SGLLPYGNFEEAGETSPTLFYNDANQHVAKMVETRIANANSPWLAGVEVGDIHAIPVS
                     HGEGKFVVSASEFAELRDNGQIWSQYVDFDGQPSMDSKYNPNGSVNAIEGITSKNGQI
                     IGKMGHSERWEDGLFQNIPGNKDQTLFASAVKYFTGK"
     gene            complement(15552..16256)
                     /locus_tag="VHC05_001449"
     CDS             complement(15552..16256)
                     /locus_tag="VHC05_001449"
                     /EC_number="6.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HEQ5402744.1"
                     /translation="MTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDG
                     KGALNNQISSLIFEKLNKAGVVTHYIEQISKNEQLNKKVDIIPLEVVLRNVTAGSFSK
                     RFGVEEGRVLETPIVEFYYKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINEL
                     LKGWFAQIGLNLIDFKLEFGFDQEGTIILADELSPDNCRLWDKNGNHMDKDVFRRDLG
                     NLTDVYQVVLEKLIAL"
BASE COUNT         4642 a         3761 c         3105 g         4782 t
ORIGIN      
        1 aacatcagat aaatttgcag atttattttt attacatata tgacatgatg gaatcaaatt
       61 agctggggta acagcgaaaa taggaaattc agattgtggt aataaatggt ctaaatcgct
      121 tactaagtcc ctctcgcaat acacacattg attaaaattt ttattttcat ttgttctcag
      181 tctgaggtaa tacgagtctt tatatttcgt aactaatttt tgcttgtaga gaaattccat
      241 ttcttcctta ccaatttcct ctgatactct gcaatcgctt tgacgtaagc tatgtagagt
      301 acctgattcg gcaagtttta tgtatattac ttcaaattca aatattctat tttttacact
      361 atcattaaat aattcagtat actttttaga atctattcta ttaccttgat catccgtgaa
      421 ttctttgctt tttgttacac catctaataa ctcatccaat atatctttca cactaaaaca
      481 aggtggagta agtttaagca tttctacctt cttccttgtc tctttttaaa atttcagtta
      541 gtaacaattt atatcctaat gtccccattc taccatcaaa tcgctgtaat gaatcttcaa
      601 atgaaagatt ttcttttact atttgattta ttaaagtata aaatcctgat tctattgctt
      661 ccaactcaaa tatatcaaac gttaaactcc ctatatcttc agcaaaagtt tcattacttg
      721 gtcttactgc ttgcataaaa tcagtgctca tctccctaga taatttataa acacattcct
      781 tttgtacttc ctgtaagata atgggagaat gcgttgctag tatcgcaaca ccattcgctt
      841 ttataaggag ttgagataaa cttctgataa agctactcaa caaaggtgga tgcaagtgta
      901 actctggctc atctaaaata acaagtgttt tttctgagac catctctact agcttagtta
      961 tggttaaaat tacaatttta tgacccgagc tcagacctct aaaaatttta tacgcctctt
     1021 tataaaactt acgaatatca tcttcttgtt gaaatgtttc gactaatgtg tcaattccta
     1081 tttgactaaa tattggatca ctatataaaa tttttatgca atctcgccat aattttggtt
     1141 tctttcgtaa tgccgtactc acactttcaa taaatactgc gtcccatccc tcgggtacgt
     1201 actctactat ttcaccatct tcttctttgt atagcttata atttttagac tcttttgcag
     1261 ttgttctgtt tgataggtga tagtacagat accccttact agcttcatga ttctcttcaa
     1321 aaagcttttt gttctcaaag ctactaaaat taacagagat aatattcgag aaaaaattat
     1381 cgtcaaactc agtattaaaa ctgaaacgac catcattttg tatcgcgctt tctaccatct
     1441 cagttaacaa atatgattta cctacaccat ttctaccgat aatggcatgg atatttgaag
     1501 caggaaattc agtgggactc actttgaaat tcaatgtaca agcatcagac attttgaaag
     1561 aaaaatcata atttgataat ttggtatttc cattagctaa tcgtctatac ttattaacaa
     1621 ttacttgagg taagagatcc ctcgttaaag acacattaaa aacatcagtt tttacagctt
     1681 tatgatacaa atcgttatca aaggcaacat cttttaaagc agttaaaata tactccctct
     1741 tttcactttc aagcctgtta atctcgtaat agaaactttc atccgtggct actgaaaaaa
     1801 aatcatcagt taaactgtca aattcttcag gtaaattggg aactcgttgt ccttcgacca
     1861 tagaaaactg accaatctta attgaaccca catttgtagt ttgattattc ttttttatat
     1921 aaaatagata tgttgtttcg tatttaaacc aatcatccca gttactatgt accaaatagt
     1981 aaccgtcatt ttgaatatcc caatacgtct ccactacttt aaaagtcata tttaaatttc
     2041 tccatacttc caattaatct cttccccaaa ctctacttca tcttctttca acaccgtcac
     2101 gtgtcccatt ttgcggttat gtttcgcttc tagtttacca tacatgtgga ggtgggcgct
     2161 agggttttca gtcacatagt caattgcctg ctggacgtgt tgtccgagga cattaagcat
     2221 gacggctgga gcatggaggt ggatggttgg gagcggcgct cctagcacgc ccaaaatgtg
     2281 ggtgtcaaac tgtgaaaagt cgcaagcctc gattgagtag tgccctgagt tgtggggacg
     2341 tggggcaatt tcattgacaa tgatatcatc tgcggtcgca aacatttcca cacagagagt
     2401 tcctgacagc tggagtttct tggcaatctg caccgccatt ttcttagcct tatcagccag
     2461 ttgatctgag atgcgagctg gcacgatagt ttttgacagg atattattgc agtggatatt
     2521 ttcctgaacg ggaaagaccg tcacatcctc tccgtttcca gacacgataa ctgagatttc
     2581 aaggtcgaaa ttgacaaact cttccaagac acactgagct gagttagcta attgctgcgc
     2641 ctctggcaaa tcttctgctg agcggataat cttttgccca tgaccgtcat aaccacctgt
     2701 cgctgtcttg aggacatagg tcttggtcaa atcaagcccc cctaggtcaa ggctagacgt
     2761 catcacctta tagggagcga ctgtcacacc agccttattt gccagaaagt ctttttcaac
     2821 gatacggttt tgggaaatgc ggagcagatc ggtcccctgc ggtagctgac aagctgacac
     2881 aacggcatcc aaaccgtccg catcaacatt ctcaaactca taagtcaata catcgcaacg
     2941 cgcagccaat tgtcccaaag cctcaacatc atcgtaaggc gccacaatta cctcgctaac
     3001 gcgggaggca gggcagtcgc tagcaggatc cagcgtgatg accttgtggc ccatgtagat
     3061 agccgcaatc gccatcatct gccccagctg accaccacca ataatcccaa tggtcttaaa
     3121 tgagttcacc acttgactcc tctgcgattt ttccttgttc ctcatggaag tgagctagcg
     3181 catcagccag attttgatcc tcgatggaga gaatacggag ggctgtcagg gcagcgttag
     3241 tcgctcccgc ttctccgata gccatggttg ccacaggcac accgccaggc atctgcacaa
     3301 tcgaatagag tgaatccaaa cctgaaaggg cacgtgattt gacaggcaca ccgataacag
     3361 gcagcgttgt tttagctgcc accataccag gcaagtgagc tgccccacct gctcctgcga
     3421 tgatgatttt gatgccacga ccacgtgctt cctcagcata cttgaacatg aggtcgggcg
     3481 tgcggtgagc agagacgact ttcttctcgt aagcaatgcc aaagttgtct agaacttcag
     3541 ccgttttttg catggttgcc cagtcagatt tggagcccat gataatagaa ataattggag
     3601 ttttcataat taagatacaa aggggcgttt cgacttgtcg aaactttccg tagaaaaata
     3661 tgcggtaagt ccgaaatctt tgatttcgaa gacgaaccta cgtcagggcg actaggtgct
     3721 ttagcatcag acgcctacga cgcagaaaac taacgatgac gcttgcgtcc aggtagtttt
     3781 atttttttcc taggaaatta gtcccgtgtt cagttccttt cttctttctt tttggagcga
     3841 ccttcggtcg ttgattgctg acgctaatat ttgaatggtt agtcttattc tcttatagct
     3901 ttgcttccga tgtcatttcg gtagaagaga cctgttgggt cttgttgggc cagttgggta
     3961 tagattttgt cctgccctgc tttgacgctg tcttctgtgg tgacaagcat atagacgcgt
     4021 cctccgtttg agagtagcgc tttgctattt tctgcaaact tagctccggc atagtaggtg
     4081 atgatatcgc cgtcggtctt ttcaggcagt ggcacacctt tctcataatc gagtggatag
     4141 ccttctgagg caacgacaac acccaaagtc acaccgtcat tctgccaagt gatgtaaggc
     4201 tcaatgccca tcatgatatc gtcaatattc tgagcgaaat cggaagtcag acgagggagg
     4261 ataatctgag tttcagggtc accgaaacgt gagttgaact cgataacctt aggtccatca
     4321 gctgtcagga taagccccac ataaaggaca cctagataag gacgcccttc ggcaaccatg
     4381 ccctcaagga caggcctaac gatcgtctca accgctgtgt ctaccacgct ctgaggtaga
     4441 tgaggaactg gcgcataggc acccatacca ccagtgtttg gccccttgtc tccgtcaaag
     4501 gcacgcttgt gatcctgagc tgtcggcatg atgtagaact tatcaccatt aacaaaggca
     4561 aagagggaaa actcctcgcc atccaagaat tcctcgataa ccacacgcgc tcctgagtcg
     4621 ccaaacttat tgtccagaag catctcttgc gccgcctcta ccgcctgctc aacggtttca
     4681 gccacgacca cacccttacc tagcgccaag ccatcagcct tgaccacgat aggtgcgccc
     4741 tgctcttcga tgtaggcttt ggctttttca aagtctgaaa atgtgccata ggctgctgtt
     4801 gggacattgt atttgaccat gatttccttg gcaaagtctt ttgaccactc tagctccgct
     4861 gctgcctttg ttggaccaaa agctctgagt ccagcactgt tgaaatcatc aacgatacca
     4921 gctgctagcg catcatcagg accaataaag gcccaagaaa tctcattctc cttcgcaaag
     4981 gcaatcaacc tggaatgttc ggaaactact atattcacca agtccagacc atccaaggtc
     5041 ataccatcat taccaggtgc cacaaaaacc tgatccacac ccttagacgc taacaacttc
     5101 ttagcaatcg catgttcacg accacctgaa ccaacaacaa gtaatttcaa aacacccacc
     5161 tctttcgtat tataattaga tattatatca taaacgttcg ccttttgata caatgtatta
     5221 attatcaata attgaaacat tgtaaaaatg tgatagtaga ccacaattct tgaaataagg
     5281 aacactctat tagccaatca aatagttatt taatatcaag taaagccaat tttcaaaata
     5341 atcatctaaa aataacattt tttgtttctt gctttcgaat aataagttac aggaggtaat
     5401 taatgaaaaa atttcatcgt tttttggtct caggagtaat ccttttaggt tttaatggtc
     5461 tagtacctac tatgccatct acacttattt cgcaacagga aaatcttgtt catgcagctg
     5521 ttttaggcga taactatccg agtaagtgga aaaaaggcaa tggaatcgat tcgtggaaca
     5581 tgtatatccg ccaatgcact tcttttgcag cttttcgttt aagctctgct aatggttttc
     5641 agttacctaa aggctacggt aatgcctgca cgtggggaca tatcgcgaaa aatcagggtt
     5701 atcctgtgaa taagacacca agcatagggg ctatcgcttg gtttgataaa aacgcttatc
     5761 agtcaaatgc tgcttacggt catgagcatg ggtagctgat atccgtggag acactgtcac
     5821 tatcgaagag tataattaca acgctggaca aggccctgaa agataccata agcgtcaaat
     5881 tccaaaatct caggtaagtg gttatatcca ttttaaagac ttatcatctc agacaagtca
     5941 ttcctaccca agacaactaa aacacatttc tcaagcttca tttgacccct ctggaactta
     6001 tcactttaca accagattac cagtcaaagg acaaaccagt atcgatagtc ctgatcttgc
     6061 ttactatgaa gcaggtcaat ctgtttatta cgataaagtc gtgactgctg gaggttatac
     6121 atggcttagc tacctcagtt tttctggaaa ccgacgctat attcccatta aagagcccgc
     6181 acagtctgtg gttcaaaatg acaatacaaa accttccatt aaggtcggtg atactgttac
     6241 cttccctggc gtttttcgtg tagatcagct tgttaataat ttgatcgtta ataaagaatt
     6301 agccggagga gacccaactc cactaaactg gattgatccc acaccattag atgaaacaga
     6361 taaccaagga aaagttttag gagatcaaat tctccgtgtg ggtgaatatt ttaccgtcac
     6421 tggtagttat aaagtattaa aaattgatca accaagtaat ggtatttatg ttcaaatcgg
     6481 atctcgtgga acatgggtaa atgctgataa agctaacaaa ttatagttaa cttatatttt
     6541 cttttaataa aaaaatgtgg ttttaattag accacatttt tttattaatg cctaaaatgt
     6601 ctcacacctg tgaagatcat ggtcaagcca tgtttgtttg cggcgtcaat agagtcttgg
     6661 tcacgaactg agccgcctgg ctggatgatt gctttgaccc ctgcggcagc gacttcttca
     6721 atgttgtccg caaatgggaa gaaggcatct gatgctagaa cggcaccgtc aaggtggtct
     6781 ttagcctgct cgatagcaat cttgactgag ccgacacggt tggtttgacc tgcaccgagt
     6841 ccaagcgtca tgtgatcgtt agtaataata atcccgttag acttaacgta cttgatagcc
     6901 ttccaggcaa actcaagggc agtcgcctct tgttctgttg gttggcggtc tgtcaccact
     6961 tgccagtcag atggattttc agctacaacg tcttggtttt gcaccaaaag tccaccaact
     7021 acgccagtgt actcagcttc cacttcgctg gcagcttggg catcaaacgg caactcaagg
     7081 atgcgcaagt ttttcttttt atttgtgaga atagctagcg cttcttctga gtatgatggt
     7141 gcgatgatga tttccaagaa gatagggtgc atcttcttgg ctgtcgctgc gtcaacttca
     7201 cggttaagga cgacaattcc accaaagatt gaaactgggt cagcttcata agcgtaatcc
     7261 caagcagtct caatgtcatc agcctgtccg ataccacatg ggttcatgtg tttgagggca
     7321 ataactgtcg gacggtcttt gaaatcgcgg ataatacgga ttgctgcatc ggcatcacgg
     7381 atattattga aggacaattc ttttccgttg agctgtttag cagaagcaat tgagtagtct
     7441 gttggcaagg ctttttgata gaaatcagcg tcttgttgtg gattttctcc ataacgcata
     7501 gcctgtttaa ggtcgtaagt gatggttaat ttttcaggct tagcctctcc cacttgagct
     7561 gtgaagtact cagcaatcaa agcgtcgtag gctgctgtgt gacgaaagac cttagctgcc
     7621 aagcgttgac gcgtttcaaa tgtcgtctga ccagcgtcag ctaattctcc caaaacagtc
     7681 gcatagtccg ctgggtcaac cacaacggtc acgctagcat ggttttttgc ggctgagcga
     7741 agcattgatg gaccgccgat atcgatattt tccaccgcca aatcataggt cacgtctgga
     7801 cgaaggatag tctccttgaa gggatagagg ttgataacca cgaggtcaat cagctcgata
     7861 ttgttatcct tagcagcctg aaggtggctg tcaacatcgc gacgggccaa aagcccaccg
     7921 tgaatgtttg gatggagggt cttaacacga ccgtccatca tttctgggaa tccagtcaca
     7981 tcgtcgatgg caatagtctc aactccagca ttatcaaggg caaccttagt cccaccagtt
     8041 gagataatat cccaacccaa gtttttcaat tcttttgcaa agtcaataat tcctgactta
     8101 tcagaaactg agattaaagc acgtttagtc atatttaaga taccaagtcc gactagaagg
     8161 ccaaggaaaa ataggaaact cgacgaagac gcttgcgcct aggagatgtt tatctttttt
     8221 ctgtgccttc cagacgggtt caattccttt ctttttggaa cgttaattct tctttactat
     8281 ctttcctaac tttacctaaa attttaagat aaaggctaga ttactttcct ctccactccc
     8341 aagctatcta agacagctgg gtagagttga tattcggttt catggatacg ggtttcaaag
     8401 ctttctaggc tatcgtctgc taggcgtggc acgcgcactt gttggatgac ctgaccggta
     8461 tccacaccag agtcaaccca gtggatggtc acgccagact ggtcaacacc agcttcccaa
     8521 gcatcctcga taccgtgggc acctggaaat tcaggcaggt aggctgggtg aatattgatg
     8581 atacgcccct cataggccaa gagtaaggtt tctccaacaa tcttcatata gcccgccaga
     8641 cagactaagt caatctcgtg tttgtccaac aaatcaacga tggcttgctc gtaagccgcc
     8701 ttattctcaa actccttgag ttcaaaagcg aagcttggaa tggctaaatt ctgagcacgc
     8761 tctaaaacat aggcatcacg atgatctgaa aagacaaaac taactagaaa ctgctctgct
     8821 atgacctgaa agttggaacc attaccagaa gcaaaaacag cgattttcat attcgataca
     8881 aagggatgat tcggcttgcc gaaaaatttc gtagaaaaat aggaaaacga acaacgacgc
     8941 ttgcgtctaa gtcattttat cttttttcct agaaatttaa tcccgtgttc agttaggcaa
     9001 actaactaaa cactcctttc ttataaaatt tagtgactta tttaatcacc acactatcgt
     9061 ctgctttctt gatgatacga ccgatttcat aaactggttc atccaagagc tctttgacgc
     9121 ggttaacatt ttcaggacta acagctagca taagaccgac acccatattg aagatttcaa
     9181 acatttcttc gtgcttgatg tcaccatatt tttcaagcgc cttgaaaatc ggaagcactg
     9241 gcaccttgtc ctcatcgatt tccgcagcca aatcatccgc aaacatacga ggaatattct
     9301 cgataaagcc accacccgtg atgtggccga taccgttgac tagttcttcc ttgattaatg
     9361 gcagagctgc tttaacatag atacgagttg gctcaaggag gacatcctta agttgtttgc
     9421 cttcaagctc tggaagcagc tctttaccag tatagtcagc aaagacacga cgtaccaaag
     9481 aataaccgtt tgaatggata ccacttgaag caagtcccaa aagaatatcg ccttctttta
     9541 cttttgaacc gtcgatgatt tgagattttt cagccacacc aacagcaaag ccagcaaggt
     9601 cataatcatc ttcgccatac atcccaggca tttcagcggt ctcacctcca atgagtgctg
     9661 ctcctgcttg aacacaacct tctgcaacgc cagaaacaac ttcttcaagt ttgactgggt
     9721 tattttttcc tgtcgctacg tagtcaagga agtaaagggg ctcagcacct gctgcaataa
     9781 tatcgttgac acacatggca acacagtctt gaccgattgt gtcgtgcttg tcgtacttga
     9841 tagcaagcat aagttttgtt ccgacaccgt cagtccctga aaccaagaca ggctctttaa
     9901 ctcctgtttt actcaagtca aacatcccac caaagccacc tagaactccc ataactcccg
     9961 cacgttctgt acgagcaacg tgttttttta ttctttcaac cacttcataa ccagcttcaa
    10021 catcaacacc agattttgca taagcatttt tttcagacat gttttctcct tatataatta
    10081 gcagagctta tttcactttt tgaatataaa aacttgtttt ctcttctaaa cttctgaggt
    10141 attcttcttc ataatcataa agcggtgttg gataatgccc atcaaagtaa gctacgcata
    10201 aaccaccatt tggtgctttt gtttcgagtc caattgattc aatcaaccca tctaatgaga
    10261 gataggtcag actatctgcg ccaataatat cacacacttc gtcaacagcg tgatttgctg
    10321 aaattaattc tcgtcttgtt tgaatatcaa taccataaaa acaaggatac tttaattctg
    10381 gactagctat agcaacatgt acttcactag ctcctgcttc tcttaataat ccgacaatcc
    10441 ttctagaagt cgttcctctt acaattgagt catcaatcat aacaacgcgc tttcctttga
    10501 caacaccaga taccgctgat agtttcattc gaacaccttg ttcccttaat tcttgtgtcg
    10561 gttgaataaa ggttcgctgc gtatactgat tttttacaag acccatctca tttggtaatc
    10621 cggattcttc agcaaagccc atagcagccg ataaggacga atttgggaca ccaattacaa
    10681 tatcagcatc ctgtttaaat tcttgtgcaa gacgctttcc catatttttt cgagccgtat
    10741 gaacattaac accatgtata gttgaatccg gccttgcaaa atagacatat tccatcgaac
    10801 aaattgccag ttgcgtttca tcagtataac gatcacattg aataccacta tcgtctataa
    10861 gaataacttc gccaggttca acatctctaa cccattttgc gcctaccacc tcaaaagcac
    10921 aggtctcact ggaaataacc caggcaccat tttgcatttg tccaattgac aaaggacgaa
    10981 aggcattagg gtcaagagca gcaattaatt tattttctgt catcagtaga taggcaaagc
    11041 caccctttac tgtatttaga gcttctttta cctttcccat gaaatttgag ttatggcttc
    11101 gacgaatcaa atgcattaaa atttcagtat ctgaggaggc attgaaaatt gcaccttgct
    11161 tttctaattc tttccttaag gaaatagcat ttgtcaaatt accattatgg cataaagcaa
    11221 attgcccgtc atgaaattta taaagaaaag gctgaatatt gcgaatatct gcagaacctg
    11281 cagtagcata ccgaacatgt ccaatagccg cattcccagt taaattatct aattcagatt
    11341 gattcttaaa aacttcagaa agaagcccaa catttcgata accatagagt ttcccattgt
    11401 catttgaaac aataccagct ccttcttgac cgcgatgttg aaggctatga agcccaaagt
    11461 aagtgacttg agctgcctga ggatgccccc agataccaaa gactccacat tcttcattta
    11521 gagattttac ttcgtatgtc atttttacct cgatacaaag gctgtcaagt aaagcgaaaa
    11581 tagaaagttt ttcgcacaac ttatcgcccg tgtttactat ttctcaaaaa tcaagcgaga
    11641 ttctttctaa cctcgccctt cactacttca aggcgaaggc taaaaaggtt cactgaacct
    11701 ttttacttcc ctgtaaagta ttttacagca cttgcaaaga gggtttggtc tttgttacca
    11761 gggatatttt ggaagagtcc gtcttcccag cgttctgagt gtcccatctt accgatgatt
    11821 tgaccattct tgctggtaat cccttcgatg gcattgacag agccgtttgg attgtattta
    11881 gaatccatag atggttgtcc gtcaaagtcc acatattggc tccagatttg accattgtct
    11941 cttagctctg caaattcaga agcgctgaca acaaatttac cttcaccgtg tgaaactgga
    12001 atggcgtgaa tatcgccgac ctcaactcct gccaaccaag gtgagttggc atttgcgata
    12061 cgagtctcaa ccatcttggc aacgtgttgg ttcgcatcgt tatagaagag agttggactt
    12121 gtctcaccag cttcctcgaa gtttccgtat ggaagaagac ctgatttaac aagggcttgg
    12181 aaaccattac agataccaat gataaggcca cctttttcga tgaagctgtc aatagctgcg
    12241 cggaccttct cgttaagcaa gatattgacg ataaacttag cagacccatc tggttcatcc
    12301 gctgctgaga agcctccagc aaagaagatg atatttgcct tagcaatatt agcaaccata
    12361 gtgtcaactg actcagcaat agcaatctca ttcaaggtta caaatggtac caagttgaca
    12421 ctagctccaa cctgttcaaa ggccttagct gaatcatact ctgagttggt accagggaag
    12481 acaggaatgt aaaccactgg tttttcaatt gtttccttag ccttgataac agtatctgat
    12541 accacagcag gaacttcttc aagagcgtct gcctgttcga attctgttgg gtaaacctct
    12601 tcaaatttgc cttcgaaagc tgctagaagg ctagcgccag caaggtcatt tccattgaca
    12661 gtgactgtaa agtctgcctg agtttgaccg attttcaccg cgtcagcaat ttcctcagct
    12721 gatgtaaaga caaaacctcc gagttgagct gtcaagctgc tgtcaagctc tgcaatttca
    12781 acagaagcac cgatacggtt accaaaagtc atgagagcaa gactttctag gacaccaccg
    12841 tatttagcgg ctgaggcagc tgtaatctta tgttgagctt gaatagcctc aaactggcta
    12901 aagttagcct tgataagatc aaaatcaata tcttctgaaa tagcttgacc tgggatatag
    12961 taaatgtttt cgccagccgc tttaaactca ggagagagaa tcttgcggct gtccgctgtt
    13021 gtcacaccga aagctaccaa ggttggtggt actgtcaagt cttcgaaagt accagacata
    13081 gagtccttac cgccgattga tggcaaacca agttgaatct gagcctcaat agaaccaaga
    13141 agagctgata ctggctgacc aaaacgctct gcctgtttat ccatacgctc aaagtactct
    13201 tggtaagaga aacgtgcacg agaccagtca gcacccgttg ctaccaagcg agctgtcgct
    13261 tcaatgacag cataggcagc accgtggtaa ggtgaccact cagcaatata aggattgtaa
    13321 ccttgagcca taacagatac tgttcttgtc acaccatgtt gaactggcaa tttttgaaca
    13381 gaactttctg tcggtgtgat ttggtaacga ccaccgattg ggtggttaac ggttgagcga
    13441 ccaacagatg agtcaaagat agtttgaaga cctttttgac tagcgtggtt gaggtcagac
    13501 aagaccttaa gcgtatctgc ttcaagtgtc tctgctgatg ttgtgcgtgc ttctggaact
    13561 gtcaagtcct tgtcaacgac tttagcatca ataacgacac ggacaccgtt ggtatcaagg
    13621 aaacggcgtt ccaagtcaac gatggtttca ccattccaag tcatgacaag atttggtttc
    13681 tcggtaactg tcgcaactac aacggcatcg atattttcct tgttgcaagc tgcgatgaag
    13741 gcatccacat cacttggacg aacaacgact gacatacgct cttgagattc tgagattgca
    13801 atttcagtac cattaagacc ttggtattta attgggacct tgtccaaatc gatttcaaga
    13861 ccgtcagcca attcaccgat agcaacacag acaccaccag caccaaagtc gtttgatttt
    13921 ttgatgagac gagtcacttc accatcacgg aagagacgtt gaatcttacg ctcttcgatg
    13981 gcattccctt tttgtacctc tgcgccagct gtttccacag actcaaccgt ttgaacctta
    14041 gatgaacctg tcgcaccgcc gacaccgtca cgccctgttt taccaccaag caagattacc
    14101 acatcacctg cttctggttt ttcacgaacc acattttcct taggtgccgc tccgaccaca
    14161 gctccaagct ccatacgttt ggctacgaag ccagggtgga agtactcacg cacataagtt
    14221 gtcgcaagcc caatttggtt accatatgaa gaatagccgt gcgccgcagt tttagaaata
    14281 acttgttgtg gaaatttacc agcacgtgtt tccgcaatcg gagtcgtgat atcgcctgcg
    14341 cctgaaatac gcatagcctg ataaacgtat gaacgccctg acaatgggtc acgaatagca
    14401 ccaccgatac aagtcgccgc tccaccgaat ggctcaattt ctgttgggtg attgtgagtc
    14461 tcgttcttaa acatgaggag ccaaggctct ttcacaccat caacatctac ttcaatctca
    14521 actgagcagg cattgatttc atctgagact tccatatcgt ccagacgacc gttggcacgc
    14581 tcataacgac caaaaatagt cgccatatcc ataagtgttt gtggcttttc agaacgacca
    14641 agctcatcac gcatggcgat atatttgtca taagttgtct gcaattgttt ttggaattta
    14701 gaagctgaaa aatcaatgtt cttcaattca gtttcaaagg ttgtgtgacg gcagtggtct
    14761 gaccagtaag tatccaaaac tttcaactca gtctcagttg gcacacgtcc gattgatttg
    14821 aaataatctt ggatgaagag aaggtcatcg acctccatag ccaagccctg atctgcctta
    14881 taggccgcaa aatcgtcagc tttataattt tcaaagaaat caagattagg gatcgtctta
    14941 tcagatacag agaaagcctg ctcttcaagc ggcaaagtaa tgtccttgaa acgcgaatca
    15001 acagggttca aaagatagtt cttaacggct tcaagctctg cttctgcaat atccttattg
    15061 accaagtaaa gctgggctgt attgacctta acctgactgt cacttccaaa taatagcaaa
    15121 gcttcttgcg aactagcagc acgttggtca aattgaccag gaagcgcctc aatggcaaag
    15181 aaggcaacct tatcaagctc cgaagtgatt tcagcttccg tcaaaagacg gtctgtcacc
    15241 tgctcagaga aaatatgctt ctcagcacgc gccagtaaat cctcagccaa attgaagaca
    15301 tcatagacct gcacaatacg caagtccttc aaagaagtca gttgtagatt atgtgtcaac
    15361 tctttcacaa ggctagccga tttaatgcca aagtcagcct ttttctcaac aaaaatacgt
    15421 ttattcatat aagataccaa atccgacaag ggagcgactg gaaaatagga ggacatctga
    15481 aattgagatt tcagtaagtt ccatcttttt ttcggagttt cccgaacgga ttcaattcct
    15541 tcctcttcta gttacaatgc tattaacttc tcaagtacaa cttgatagac atccgtcaga
    15601 ttgccaaggt ctcttctaaa aacatccttg tccatatggt taccattctt atcccatagg
    15661 cgacagttat caggcgaaag ttcatctgct aagataattg taccttcttg atcaaatccg
    15721 aactccaact tgaagtcaat caagttaagc ccaatctgag caaaccaacc tttcaagagt
    15781 tcattaatac ggcgagtctc tcctttcaga taagcaatct cctcatcatt aacaataccc
    15841 aaaaacttca catgctcatc attgataaaa ggatcattca gatcatcatt tttgtagtaa
    15901 aattccacaa ttggcgtttc aagaacacgt ccttcttcca ctccaaaacg ttttgaaaat
    15961 gagcctgctg tcacattccg taacaccacc tcaagtggaa taatatcaac ttttttattc
    16021 aattgttcgt tttttgaaat ttgctcaata taatgtgtca ccacaccagc cttatttaat
    16081 ttctcaaaaa taagagatga aatctgatta tttagtgctc ccttgccatc aatagtctcc
    16141 ttacgagctc cattcaacat agtagcttgg tctttataga ccgttctaat tacattttca
    16201 tcttttgtac tataaatatc tttcgctttt cctttataaa taagctggtt agtcacttga
    16261 ttattcgcct ttctttctgt tttcatttaa
//
LOCUS       DAUDWO010000042        15596 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.043, whole genome shotgun sequence.
ACCESSION   DAUDWO010000042 DAUDWO010000000
VERSION     DAUDWO010000042.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15596)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15596)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15596
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.043"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            44..697
                     /gene="grab"
                     /locus_tag="VHC05_001450"
     CDS             44..697
                     /gene="grab"
                     /locus_tag="VHC05_001450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G-related alpha2-macroglobulin-binding protein
                     GRAB"
                     /protein_id="HEQ5402745.1"
                     /translation="MGKEIKVKYFLRRSAFGLVAVSASVLVGSTVSAVDSPIEQSRII
                     PNGGTLTNLLGNAPEKLALRNEERAIDELKKQAIEDKEATTAIEAASSDALEALADQA
                     DALQSEEAAVVQSDTAASDALEALADQTDALQSEEAAVVKADTAASDAWEKAATPIAL
                     DVKKTKDTKPVVKKEERQNVNTLPTTGEESNPFFTAAALAIMVSIGALVVSSKCKEN"
     gene            935..1477
                     /locus_tag="VHC05_001451"
     CDS             935..1477
                     /locus_tag="VHC05_001451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEQ5402746.1"
                     /translation="MDIWTKLAVFAFFETPKVILRPFRYEDHWDFYSMVNDTKNLYYV
                     FPEQKTKAASDYLLVHSFIKFPLGQWAIEDKATHQVIGSIRIEHYDAKTRCADIGYFL
                     NYAFWGQGIMTEVVIKLVYLSFHEFGLKTLRIITHLENKASQKVAKKAGFQLKTCFKG
                     SDRNTHKICIYKMYQLTNDR"
     gene            1486..2769
                     /locus_tag="VHC05_001452"
     CDS             1486..2769
                     /locus_tag="VHC05_001452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008090728.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEQ5402747.1"
                     /translation="MSKHQDILDYLEKLAIGKKVSVRSISNHLKVSDGTAYRAIKEAE
                     NRGIVETKPRSGTVRIEKKGRVRIDRLTYSEIARISDSEVLAGHAGLGHEFSRFSIGA
                     MTQQNIRRYLVKGGLLIVGDRETIQLLALENHNAILVTGGFPVSKRVIEMANNQRIPV
                     MVTHYDTFTVATMINHALSNIRIKTDLKTVEQVMIPITDYGYLCEDSSVEEFNTLIKK
                     TRQVRFPVLDYKRKVIGVVSMRDVVDQLPTTKLTKVMSKNPITARPNTSLANISQKMI
                     FEDLNMLPVTDEENNLLGMITRRQAMENLPNHQPNNPYTYSEQILSNLEETVDYYQVV
                     VEPTMIDSAGNMSNGVISEFLKEISIRALTKKHQKNIIIEQMMIYFLHAIQIEDELKI
                     YPKIITENRRSSTIDIEIFVDDQVIAKAIITTKIN"
     gene            2785..3645
                     /locus_tag="VHC05_001453"
     CDS             2785..3645
                     /locus_tag="VHC05_001453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl aminopeptidase"
                     /protein_id="HEQ5402748.1"
                     /translation="MITLKSAREIEAMDRAGDFLAGIHIGLRDIIKPGVDMWEVEAYV
                     RRRCKEDNVLPLQIGVDGHMMDYPYATCCGLNDEVAHAFPRHYILKEGDLLKVDMVLS
                     EPLDKSIVDVAALDFDNVPEMKKWTGSYTGGLADSCWAYAVGTPSDEIKQLMDVTKEA
                     MYRGIEKAVIGNRIGDIGAAVQEYAESFGYGVVRDLVGHGVGPTMHEEPMVPNYGTAG
                     RGLRLKEGMVLTVEPMINTGTWEIDTDIKTGWAHKTLDGGLSCQYEHQFVITKDGPVI
                     LTSQGEERTY"
     gene            3647..4612
                     /locus_tag="VHC05_001454"
     CDS             3647..4612
                     /locus_tag="VHC05_001454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="HEQ5402749.1"
                     /translation="MAEKKWFDKVLSKWQYEPIQVFMRHLQSAEMDLSAIAVAYYLIL
                     TAFPLIVIAANIFPYLNIDIADLLRLMKQNLPKDIFRPASAIVENIFSKPSGSVLGVA
                     TLTGLWTMSRSLTSLQKAINKAYGASQHRDFFIGHLVGLLTSLIILFLLAFALIFSTF
                     SKAAIQVLDKHYHLSDNITTIFLLLIQPITVLIIFVGLMLLYFLLPNVKIKKIRYILP
                     GTLFTSFVMTFLSNLVGNYVVYNVERMVDIKMFGSVMIFIIMLWFIFLARILILGAIF
                     NATYQEMSLGKLEGRSGDMIAILKKTLGNDSGLSPSQSIEDSHTD"
     gene            4723..6006
                     /gene="aroA"
                     /locus_tag="VHC05_001455"
     CDS             4723..6006
                     /gene="aroA"
                     /locus_tag="VHC05_001455"
                     /EC_number="2.5.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012679248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="HEQ5402750.1"
                     /translation="MKLRTNAGPLQGTIQVPGDKSISHRAVILGAVAKGETRVKGLLK
                     GEDVLSTIQAFRNLGVRIEEKDDQLVIEGQGFQGLTAPCQTLNMGNSGTSMRLIAGLL
                     AGQPFSVKMIGDESLSKRPMDRIVYPLKQMGVEISGETDRQFPPLQLQGNHNLQPITY
                     TLPISSAQVKSAILLAALQAKGTTQVVEKEITRNHTEEMIQQFGGRLIVDGKRITLVG
                     PQQLTAQEITVPGDISSAAFWLVAGLIIPGSELLLKNVGVNPTRTGILEVVEKMGAQI
                     VYEDMNKKEQVTSIRVVYSRLKGTIISGGLIPRLIDELPIIALLATQAQGTTCIKDAQ
                     ELRVKETDRIQVVTDTLNSMGANIKATADGMIIKGPTVLYGANTSTYGDHRIGMMTAI
                     AALLVKQGQVHLDKEEAIMTSYPTFFKDLERLCHD"
     gene            5999..6490
                     /locus_tag="VHC05_001456"
     CDS             5999..6490
                     /locus_tag="VHC05_001456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HEQ5402751.1"
                     /translation="MTKVLLGFMGVGKTTVSKHLSMHCKDMDAIIEAKIGMSIAAFFE
                     QHGEIAFRTIESQVLKDLLFTNDNSVIVTGGGVVVLQENRQLLRKNHQHNILLVASFE
                     TLYQRLKHDKKSQRPLFLKYSKEAFYEFYQQRMVFYEGLSDLVIRVDHRTPEEVANII
                     EGY"
     gene            6698..8149
                     /locus_tag="VHC05_001457"
     CDS             6698..8149
                     /locus_tag="VHC05_001457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HEQ5402752.1"
                     /translation="MTKYPMGGLSHHEELRYFYLLRNLSYLSENEKKEFAFLKSKLEI
                     GRAYAPSKQHYRKSKRQEPYFEDDYYNDYSPNDLLEDDDVNHDSSFVPYGLPIYPKED
                     RYLNKKTKLTARRPIDTPQPIDEDDAFLTESVARCALPRSQKRKHKKKGCMKWFFNIF
                     GLLLMTVLMGLGLMFAKGVFDISTNKANYKPAVSQAFDGQETQDGTNILVLGSDQRVT
                     QGSTDARTDTIMVVNVGNHAKKIKMVSFMRDTLINIPGYSYNDNSYDLKLNSAFNLGE
                     QEDHHGAEYVRRALKHNFDIDIKYYVMVDFETFAEAIDTLFPNGVKIDAKFATVGGVA
                     VDSVEVPDDLRMKNGVVPNQTIEVGEQRMDGRTLLNYARFRKDDEGDFGRTVRQQQVM
                     SAVMSQIKDPTKLFTGSAAIGKIYALTSTNVSFPFVVKNGVSVLGSGKNGVEHVTIPE
                     NGDWVDEYDMYGGQALYIDFDKYQKTLAKLGLR"
     gene            8198..9589
                     /gene="rlmD"
                     /locus_tag="VHC05_001458"
     CDS             8198..9589
                     /gene="rlmD"
                     /locus_tag="VHC05_001458"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HEQ5402753.1"
                     /translation="MVSPRKGKRIRMLKKNDIIQVAISDLSHEGAGVAKHGGFVFFVD
                     NALPEEVIDMRVLKVNKNSGFGKVEVYHYLSPARNADVNLTYLRTGIADLGHLTYEDQ
                     LTFKKKQVQDSLYKIAGISDVTVESTIGMTEPLAYRNKAQVPVRRVNGQLETGFFRKH
                     SHDLIPISDYYIQDKEIDRLINFTRDLLRRFDIKPYDETEQTGLLRNIVVRRGHYSGE
                     MMLVLVTTRPKVFRVDQVIEKIVEAFPAVVSIIQNINDKNTNAIFGKDFKTLYGKDTI
                     TDSMLGNNYAISAQSFYQVNTIMAEKLYQTAIAFSDLSKDDIVIDAYSGIGTIGLSFA
                     KTVKAVYGVEVIEAAVRDAQQNAALNGITNAYFIADTAEHAMATWAKDGIKPSVILVD
                     PPRKGLTESFIQASVAMGPQKITYVSCNPATMARDIKHYQELGYKLTKVQPVDLFPQT
                     HHVECVSLLEKRS"
     gene            9741..10519
                     /locus_tag="VHC05_001459"
                     /pseudo
     CDS             9741..10519
                     /locus_tag="VHC05_001459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003060407.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside phosphorylase"
     gene            10604..11005
                     /locus_tag="VHC05_001460"
     CDS             10604..11005
                     /locus_tag="VHC05_001460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PaaI family thioesterase"
                     /protein_id="HEQ5402754.1"
                     /translation="MSDLTQEMTLNVISIFDNYQIELAEKGHLILSTEVTETALNYYG
                     DAHGGYLFTLCDQVGGLVARTTGVESVTLQANANYLKAGHKGDKLMVEGRLVHGGRTT
                     QVVDVTIHNQTGALLTKTSLTMFVTGRRHNG"
     gene            complement(11110..12594)
                     /locus_tag="VHC05_001461"
     CDS             complement(11110..12594)
                     /locus_tag="VHC05_001461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008090588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1846 domain-containing protein"
                     /protein_id="HEQ5402755.1"
                     /translation="MKTIAFDSNKYLNLQRDHILERISQFDGKLYMEFGGKMLEDYHA
                     ARVLPGYEPDNKIKLLKELKEQVEIVIAINANNIEHSKARGDLGISYDQEVFRLIDKF
                     NTLDIYVGSVVITQYNNQPAADAFRKQLEKNGIASYLHYPIKGYPTDINHIISSEGMG
                     KNDYIKTSRNLIVVTAPGPGSGKLATCMSQMYHDQINGVKSGYAKFETFPVWNLPLHH
                     PVNLAYEAATADLDDVNMIDPFHLETYGKTAVNYNRDIEVFPVLNRTFERILSKSPYA
                     SPTDMGVNMVGFSIVNEEAAIEASKQEIIRRYYQTLVDFKAERVTESAVKKIELLMND
                     IGVTPDDRHVTVAAHQKAEQTGQPALALQLPNGQIVTGKTSELFGPTAAVIINAIKTL
                     AKIDKTTHLIEPEYVKPIQGLKVNHLGSHNPRLHSNEILIALAITAMTSEEANLAMKE
                     LGNLKGSEAHSTVILTEEDKNVLRKLGVNITFDPVYQHHKLYRK"
     gene            12968..14188
                     /locus_tag="VHC05_001462"
     CDS             12968..14188
                     /locus_tag="VHC05_001462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEQ5402756.1"
                     /translation="MSTLSLDTTNKRALVAAIAASGTDDLNVMFLAFSMSSIMTDLGL
                     SGTQGGWIATITNLGMLVGGLLFGLLADRHHKFKVFKWTILLFSVATGLIYFTQSLPY
                     LYLMRFIAGIGVGGEYGIAIAIMAGIVPPEKMGRMSSLNGIAGQLGSISSALLAGWLA
                     PSLGWRGLFLFGLLPILLVIWMTLAIDDQKIWDHYGQEEEECSQPIKINELFKTKSLT
                     AQTLALMVMTTVQIAGYFGMMNWLPTIIQTSLNLSVKSSSLWMVATIVGMCLGMLCFG
                     QLLDCFGPRLIYSLFLLASSICVYLFQFANSMASMVIGGAIVGFFVNGMFAGYGAMIT
                     RLYPHHIRSTANNVILNVGRALGGFSSVAIGSILDASGISMVMIFLASLYVISFGAMW
                     TIGQLKAERYQQLR"
     gene            complement(14308..14673)
                     /locus_tag="VHC05_001463"
     CDS             complement(14308..14673)
                     /locus_tag="VHC05_001463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioesterase family protein"
                     /protein_id="HEQ5402757.1"
                     /translation="MTIYSHTYETHPNHSAKAMGSGTLNVLATPALVAFMENASYLFA
                     QEQLDSDFTTVGSEIAIQHLAASAIGDPVTIIITALKEEGRKYDFRLEAFVGEQLIGK
                     ACHTRVRVNSKHFMAKVAE"
     gene            14788..15519
                     /locus_tag="VHC05_001464"
     CDS             14788..15519
                     /locus_tag="VHC05_001464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEQ5402758.1"
                     /translation="MRLDKFLVATGVGTRSQVKLLLKKKAIFVNQKVETSAKAHIDEY
                     KDLVTYQGTPLVYESFVYYLLNKPSGYVSATQDRQQATVMELLDDTARQKTVFPVGRL
                     DKDTRGLLLLTNNGQLAHDLLSPKKHVTKEYLAKVAGIMTEADKDYFARGISLKDHQC
                     LPAHLEVLASDLQQQTSLVKITIQEGKFHQVKRMVAACGKEVLDLQRLSMGPLKLDPS
                     LAEGEFRRLTPEELQSLAPYCQSSL"
BASE COUNT         4834 a         2723 c         3313 g         4726 t
ORIGIN      
        1 aatttaatat gctaatgcat ataaaaataa aaaaggagaa acaatgggaa aagaaataaa
       61 agtgaaatac tttttgcgta gatcagcttt tggattagtt gcggtgtcag catcagtatt
      121 agtcggttca acagtatctg ctgttgactc acctatcgaa cagtctcgaa ttattccaaa
      181 tggcggaacc ttaactaatc ttcttggcaa tgctccagaa aaactggcat tacgtaatga
      241 agaaagagcc attgatgaat taaaaaaaca agctattgag gataaagaag ctacgacagc
      301 tatagaagca gcaagttcag atgccttaga agcattagcg gatcaagcag acgctttaca
      361 atcagaagaa gctgcagtag ttcaatcaga taccgctgct agtgacgcct tagaagcatt
      421 ggcggatcaa acagacgctt tacaatcaga agaagctgcg gttgttaaag cggataccgc
      481 tgctagtgac gcctgggaaa aagcagcaac tccaatcgct ttagatgtta agaaaactaa
      541 agatacaaaa cctgtagtta aaaaagaaga aagacaaaac gttaataccc ttcctacaac
      601 tggtgaagag tctaacccat tctttacagc tgctgcgctt gcaataatgg taagtatagg
      661 tgcgttagtt gtaagttcaa agtgcaaaga aaattagttg ctatttgttc tagcaaatga
      721 aacaagggaa tcgaaagatt ctctttttct gatatttaaa aatgctacag tttataatag
      781 cttgaaagac taaatgttct caaactcatt agaacaagct ttaataaaac taacccagtt
      841 gtatcaaagg atagataaag actaagactg ttatagaata tttgcaaaag atttgttata
      901 atggacccaa tacaggtatt gtgaaaggta taatatggat atttggacaa agcttgcagt
      961 gtttgctttt tttgagactc cgaaagtaat attacggcct tttcgctatg aagatcattg
     1021 ggatttttac agcatggtta acgacactaa aaacctttat tatgtttttc cagaacaaaa
     1081 aactaaggca gcaagtgact atcttttagt acatagtttt ataaagtttc ctttaggtca
     1141 gtgggcaata gaagataaag caacccacca agtaataggt tctattagaa ttgagcatta
     1201 tgatgctaaa acgcgttgtg ctgatattgg ctatttttta aactatgcct tttggggaca
     1261 aggaattatg acagaagtcg taataaaact tgtttattta tcttttcacg aatttggtct
     1321 caaaacgttg cgtattataa ctcatttaga aaataaggcc agccagaaag tagctaaaaa
     1381 agcaggtttt caactaaaaa cctgttttaa aggaagtgat cgtaatactc ataaaatctg
     1441 catttataaa atgtaccaac taactaatga taggtgataa tcattatgag caaacatcaa
     1501 gatattttag attatttaga aaaacttgct attggtaaaa aagtgagtgt tagaagcatt
     1561 tcaaaccact taaaagtaag cgatggaaca gcctaccgtg ctattaaaga ggcagaaaat
     1621 cgaggtattg tcgaaaccaa accaagaagt ggaactgttc gtattgaaaa aaaaggacgg
     1681 gttcgtattg accgtctgac ctattccgaa attgctcgga tcagtgattc ggaagtgcta
     1741 gcgggacatg ctggtttagg acatgaattt agtaggtttt caattggtgc tatgactcaa
     1801 caaaatattc gtcgttactt ggtcaaagga gggttattaa tagttgggga tcgtgaaacg
     1861 attcaactct tagctcttga aaaccataat gccattttgg taacgggcgg atttccagta
     1921 tccaaacgtg ttattgaaat ggcaaataac caacgaatcc cagttatggt aactcattat
     1981 gataccttta ctgtggcaac aatgattaat cacgcgctat ctaatattcg tattaaaaca
     2041 gatctcaaaa cagttgaaca ggtaatgata cctattacag attatggtta cctttgcgaa
     2101 gacagctctg ttgaagaatt caatacatta ataaaaaaaa cacgacaagt caggtttcct
     2161 gtattagatt ataaaagaaa agtgattggt gtagttagta tgcgtgatgt ggtggatcag
     2221 ttgccaacaa ctaagcttac caaggtcatg tctaaaaatc caataacggc tagaccaaat
     2281 actagtcttg ctaatattag ccagaaaatg atctttgaag atttaaacat gttacctgtc
     2341 actgacgaag aaaacaattt acttggtatg attactcgta gacaagcaat ggaaaatttg
     2401 ccaaatcacc aaccaaataa cccctatact tatagtgagc aaatactttc taaccttgaa
     2461 gaaacggttg attattacca agtagtagtt gagccaacaa tgattgatag tgctggtaac
     2521 atgtcaaacg gtgttatttc agagttctta aaggaaatta gtatcagagc cctcacgaaa
     2581 aagcaccaaa aaaatatcat tatcgaacaa atgatgatat actttttaca tgctattcaa
     2641 attgaggatg aattaaaaat atatcctaaa atcattactg aaaatagacg aagcagcacc
     2701 attgatattg aaatttttgt ggatgatcaa gtgattgcta aagctattat tacaacgaaa
     2761 ataaattaga ggagtaacaa aacaatgata acattaaaat cagcccgtga aatagaagcg
     2821 atggatagag caggagactt cttagcaggt atccatattg gcttaaggga tattattaag
     2881 cctggtgtgg atatgtggga agtggaagca tatgttcgtc gccgttgtaa agaagacaac
     2941 gttcttcctt tgcaaatagg ggttgatggt cacatgatgg actatcctta tgcgacctgt
     3001 tgtggtctaa atgacgaagt agcacatgcc tttccccgtc attacattct gaaagaaggg
     3061 gatttgctta aagttgacat ggtactcagt gagcctttgg ataaatcaat tgttgatgta
     3121 gcagctttag attttgataa cgtgcctgag atgaagaaat ggacaggatc ttataccggt
     3181 ggtttagctg actcttgttg ggcttatgct gttggaacac cgtctgacga aataaagcaa
     3241 ttaatggatg tcaccaaaga agccatgtac cgtggtattg aaaaagcagt aattggcaat
     3301 cgtattggtg atattggcgc agctgttcaa gaatacgctg aaagcttcgg ttatggtgtc
     3361 gtgcgtgatc ttgttggtca cggtgttggt cctacaatgc atgaagagcc aatggtacca
     3421 aactatggaa cagcaggtcg tggacttcgt ctaaaagaag gcatggtctt gactgttgag
     3481 ccaatgatta atacaggaac ttgggaaatt gataccgaca tcaagacagg ttgggctcat
     3541 aaaaccctag atggtggttt atcttgccaa tacgaacacc aatttgtgat tactaaagat
     3601 ggtcccgtta ttttaacaag tcaaggagaa gaaagaactt actaaaatgg cagaaaaaaa
     3661 atggtttgat aaggtactgt ccaagtggca gtatgaaccc attcaagtct ttatgaggca
     3721 tttacaaagt gcagaaatgg atttatctgc cattgcggtt gcgtattacc ttatcttaac
     3781 ggcctttcca ttaattgtta ttgcagccaa tatttttcct tacctcaata ttgatattgc
     3841 tgatttgtta cgtttaatga agcaaaattt gcctaaagat atttttagac cggcttctgc
     3901 aattgtagaa aatattttct ctaaaccgtc tggaagtgtt ttgggagtag cgactttgac
     3961 aggattatgg acaatgtctc gaagtttgac atcgctgcaa aaagctatta ataaagccta
     4021 tggcgcttct cagcatcgag atttctttat cggacacttg gttggtttgt tgaccagttt
     4081 aattatttta tttttattag cctttgcctt aatcttttca acattttcta aagctgctat
     4141 tcaagtgctg gataagcatt accatttgag tgataatatc acaacgattt tcttactcct
     4201 cattcaacct attacagttt tgattatttt tgttggcttg atgctactat attttttatt
     4261 acccaatgtt aagattaaaa aaattcgcta cattttacca ggaaccctat ttacatcttt
     4321 tgtgatgaca tttttgagta atctggttgg caattacgtt gtgtataatg ttgagcggat
     4381 ggtagatatt aaaatgtttg gttcagttat gatttttatc atcatgctat ggtttatttt
     4441 cttagcaaga atcctgattt taggagctat atttaatgcg acctatcaag aaatgtcctt
     4501 ggggaaatta gaaggtcgta gtggtgatat gatcgctatc cttaaaaaaa cacttgggaa
     4561 tgattcaggt ctatctcctt cacagtctat cgaagatagt cacactgatt gatacaaaaa
     4621 agataataag tcgtggagtg agaaactatt ttcttgcttc attttttatg aggataaata
     4681 gaaaatcatt gatcttagca aatagaaagg cagataaaac ggatgaaatt gcgaacaaat
     4741 gcaggaccat tacagggaac gattcaagtt ccaggagaca agtccattag tcaccgggca
     4801 gtcatattag gagctgttgc taaaggggaa acacgagtaa aaggactctt aaaaggagaa
     4861 gacgtgcttt ccacgattca agcctttagg aatttggggg tccgtatcga agaaaaagat
     4921 gaccagcttg tgatagaagg tcaaggtttt caaggattga ccgctccttg tcagacactt
     4981 aatatgggaa attctggaac ctctatgcgc ctcattgctg gcttattggc aggtcaacct
     5041 tttagtgtca aaatgattgg cgatgaaagc ttatccaaac gtcctatgga tcggattgtt
     5101 tatccgttaa agcaaatggg ggttgagata tctggagaaa cagataggca atttcctcca
     5161 ctacaattgc aaggtaatca taatttacaa ccaatcacat ataccttgcc tatctcttct
     5221 gctcaggtta agtcagctat tttattagca gctttgcaag caaaaggaac aacacaggtt
     5281 gttgaaaaag agattactcg aaaccataca gaagaaatga ttcaacaatt tggtggacga
     5341 ttgatagttg atggtaagcg cattactttg gtgggacccc agcagcttac tgctcaagag
     5401 ataactgtcc ccggagatat ttctagtgca gctttttggc ttgtcgccgg cttaattatt
     5461 cctggttcgg agctcctttt aaagaatgtt ggagtcaatc cgacacgaac agggattctt
     5521 gaagtggttg aaaaaatggg agcacagatt gtttatgaag atatgaataa gaaagagcaa
     5581 gtaactagta ttcgagtggt atattctcgc ttgaaaggaa ctatcatatc aggaggtctt
     5641 atccctcgat tgattgatga acttcccatc attgcacttc ttgcaaccca agcacaagga
     5701 acaacctgta ttaaagatgc tcaagaatta cgagtcaaag aaacagatcg tattcaagta
     5761 gtaactgata ctcttaacag tatgggagct aatatcaaag cgacagcaga tggcatgatt
     5821 atcaaaggcc ctacggtact atatggggct aacacaagta cctatggaga tcatcgtatt
     5881 ggtatgatga cagcaattgc agccttgctt gttaaacaag gacaggttca tttggataaa
     5941 gaagaagcca tcatgacgtc ttatccgacg tttttcaaag atttagaaag gctgtgtcat
     6001 gactaaagtg ttattgggat ttatgggagt ggggaaaaca acggtttcga aacacctaag
     6061 tatgcactgt aaagatatgg atgctattat tgaagctaaa atcggtatgt ctattgcagc
     6121 tttttttgaa cagcatggag aaatagcatt tcgaacaatt gaaagtcaag tgttaaaaga
     6181 tctattgttt acaaatgata atagtgtcat cgtaacaggt ggcggtgtag tggttttaca
     6241 agaaaatcga caattactga gaaaaaatca ccagcataat attttattgg tagcttcttt
     6301 tgaaactttg taccagcgtt taaaacatga taaaaagtct caaagacctc tatttcttaa
     6361 gtactctaag gaagcatttt atgaatttta tcaacaacgt atggtatttt atgagggact
     6421 ttcagattta gtaatcagag ttgaccatcg tacgcctgaa gaagttgcca acatcattga
     6481 gggttattag caggtcattg tcgtaatctg atatttatgg ttttaaacag gtatctgtct
     6541 aaagtacttc ttatggcaag ttggctttat taaatattag gaaataatct tgattattct
     6601 ataatgatta aaattttgag aggacaatct ggctaatata ggttataatg gtagtattcg
     6661 ttaaaagtgc aattgtaata ctaagagatg ataagatatg acaaaatacc ccatgggtgg
     6721 ccttagtcac catgaagaat tacgttattt ttatctccta aggaatttga gttaccttag
     6781 tgagaatgaa aaaaaagagt ttgctttttt aaaatctaaa ttggaaattg gtcgagctta
     6841 tgctccttct aagcagcatt ataggaagtc aaaacggcaa gaaccttact ttgaagatga
     6901 ctactataac gactactcac caaatgattt actagaagat gatgacgtca atcatgactc
     6961 ttcttttgtt ccatatggtt taccgatata tcctaaagaa gacagatatt taaacaaaaa
     7021 aacaaaactt acagctcgta gacctataga tactccgcag cctattgatg aagacgatgc
     7081 ttttttaaca gagtctgttg ctcgttgtgc tcttcctaga tctcaaaaaa gaaagcataa
     7141 gaaaaaagga tgtatgaaat ggttttttaa catttttggc ttattgctaa tgactgtgct
     7201 tatggggtta gggttgatgt ttgcaaaagg ggtttttgat atttctacta ataaagctaa
     7261 ttacaaacca gctgtttccc aagcttttga tggtcaagaa actcaagatg gtacgaacat
     7321 tctggttttg ggttctgacc aacgagttac tcaaggttct acagatgctc gcacagatac
     7381 cattatggtt gtcaatgtcg gcaaccatgc taaaaaaata aaaatggtct cttttatgcg
     7441 tgacactttg attaacattc caggatacag ttataatgat aattcgtatg atcttaaatt
     7501 aaatagtgca tttaatcttg gagagcaaga agatcaccac ggagcagagt acgttcgacg
     7561 ggccttaaaa cataattttg atatcgacat taagtattat gtgatggtag attttgaaac
     7621 atttgcagaa gctattgaca ccttgtttcc aaatggtgtt aagattgatg ccaaatttgc
     7681 gacagtaggt ggtgtagctg ttgactccgt agaagttcca gatgacctgc gaatgaaaaa
     7741 tggggttgtt cccaaccaaa ccatcgaagt tggagaacaa cgcatggatg gtagaacctt
     7801 gctcaactat gctcgtttcc gtaaagatga cgaaggagat ttcggacgaa ccgtccgtca
     7861 gcaacaggtt atgtcagctg ttatgtccca aatcaaagac ccaactaaac tctttacagg
     7921 gtctgcggct attggtaaaa tctatgcgct gacttcgacc aatgtttctt ttccatttgt
     7981 tgttaaaaat ggtgtttctg ttttaggaag tgggaaaaat ggagttgagc acgtgaccat
     8041 cccagaaaat ggggattggg ttgacgaata cgatatgtat ggaggacaag ctctttacat
     8101 agattttgat aagtatcaga aaacgttagc caaattaggt ctgcgctaag atatggtata
     8161 atggagagta actaaagttg ctcttctttt ttgagcaatg gttagcccta gaaaaggaaa
     8221 aagaataaga atgttgaaaa aaaatgatat tatccaagtt gctatttcag atttaagcca
     8281 tgagggagca ggtgtcgcta aacacggtgg ttttgttttc tttgttgata atgccttgcc
     8341 agaagaagtg attgacatgc gtgtcttaaa ggtcaataaa aacagcggtt ttggcaaagt
     8401 agaagtctat cattacctgt cgccagctag aaatgcagat gtcaatttaa cttatttgcg
     8461 aacaggcatt gcagaccttg gacatctaac ttatgaagac caactgactt tcaaaaagaa
     8521 acaagttcag gacagcctct ataaaattgc tggaatcagt gacgtgacag tcgaaagcac
     8581 gattgggatg acagaacctt tagcttaccg aaataaggct caagttcctg ttagacgtgt
     8641 taacggtcag ctagaaacag gctttttccg caagcattct catgacttga ttcctatttc
     8701 ggattattat attcaggaca aagagattga tcgtctcatt aattttaccc gtgatttatt
     8761 acgccgcttt gatattaaac cgtatgacga aacagaacaa acaggtctct tgagaaatat
     8821 tgttgttcgc cgaggccatt actctggaga aatgatgctg gtcttagtga ctacacgccc
     8881 aaaagttttc cgtgttgacc aagtcattga aaaaatcgtt gaagcttttc cagcagtggt
     8941 gtctattatt caaaatatta atgataagaa caccaatgca atctttggta aagatttcaa
     9001 aacgctttac ggcaaggata ccattactga tagcatgctt ggaaacaact atgccatttc
     9061 tgctcagtct ttctaccaag tgaatacgat tatggcagaa aaactctatc aaacagctat
     9121 agccttttca gacctttcta aagatgacat tgtgattgac gcctactcag gtatcggaac
     9181 cattggccta tcatttgcta aaacagttaa agctgtttat ggtgttgaag tgattgaagc
     9241 agctgttaga gatgctcaac agaacgccgc tcttaatggc atcaccaatg cctactttat
     9301 cgcagatacc gcagaacatg ctatggcaac atgggcgaaa gatggcatta aaccaagtgt
     9361 tattctggta gacccgccac gaaaaggctt aacagaaagt ttcatccaag ccagcgtggc
     9421 aatgggacca caaaaaatca cctacgtttc ctgcaaccca gccaccatgg cgcgtgacat
     9481 caagcattat caagagttgg gttacaaact gaccaaagta cagcccgtag atttgtttcc
     9541 ccagacgcat cacgtggagt gtgtaagttt acttgagaaa cggagttaaa gagtccgcct
     9601 cactctgtta tttcaaggtg agacgctcaa aaggtccact ggaccttttg actcccgcag
     9661 acccatcacg tcgagtgcgt agtgttgcta atcaaggagt aaggtagctg cctccacatg
     9721 acaaaaataa ggagaaacga atgcctatta ccaaacacga gattcccctt ttagaatgtg
     9781 atagtaatcc atcagccgtc attatctagc tatttagctt ccagctaagt gtgtctatgc
     9841 tttcttagaa gacgagattg aagcttttgc tttagaccat caaggtaaaa aagtagcaga
     9901 attcatttca gccacaaagg tttaccctgt ttatcagata tcttataaag gtcaagacat
     9961 ttgcctagct caagctcccg ttggctcagc tcctgcggcg caattcatgg actggctgat
    10021 tggttatggg gttaaagaaa tgatcagtac aggaacctgt ggcgttttgg ttcctatcgc
    10081 agaaaaccgt tttttagtgc cagttaaggc tttgcgagat gaaggaacaa gttatcatta
    10141 cgtggcacca tcttgttata ttgatattga tcctaagatg cttagaccga tagagaaaac
    10201 gctttcagca caggggttag cttatcaaga ggtcatcacc tggtcaacag atggttttta
    10261 ccgagaaacc aaagaaaaag tggcttatcg ccaggaagaa gggtgttcgg ttgttgagat
    10321 ggaatgttct gccttagcag cagtagctca attaagaggc atcctttggg gacaactctt
    10381 atttacagca gatactctag cagatgtaga ggtttacgat caacgcaacc ggggcgctga
    10441 ttcctttagt tttgcgcttc atttatgctt ggaagtgttc aatacgctag aaaaggatgg
    10501 aaaggctact gatttttgaa acatgagctc tgccttctgt tcctatttgt agtataatga
    10561 ggcttgtatt gcttttagac taagcttaga aaagagaaaa acaatgtcag atttaacaca
    10621 agagatgacc ttaaatgtta ttagtatttt tgataattac caaattgaac ttgctgaaaa
    10681 aggacacctt attttaagta ctgaagtgac tgagacggct ttgaattatt atggggatgc
    10741 ccatggtggt tatcttttca ccctatgtga tcaagtaggt ggtttggttg ctagaactac
    10801 tggcgtagaa tctgtcacct tacaggccaa tgctaactat ttaaaagcag ggcacaaggg
    10861 agacaagctg atggttgaag gtcgattggt tcatggaggt cgaaccacgc aggtggttga
    10921 tgtgacgatt cataaccaaa caggagctct tctaacaaaa acaagcttga ccatgtttgt
    10981 gactggccga cgtcataacg ggtgattaat gaatcaataa aggaaaaaag tcccaactct
    11041 ctgagaattg ggactttttt cctttattga gagataccat aaatcacccg ttagacgggt
    11101 ggttatggtt tatttacggt aaagtttgtg atgttggtaa acagggtcaa aggtaatatt
    11161 taccccaagt tttcggagta catttttatc ttcttcggtt aagataacgg tagaatgggc
    11221 ttcgctacct ttcaaattgc cgagttcttt catggctaga ttagcttctt cactagtcat
    11281 agcagtaatg gccaacgcaa tcagaatttc attggaatga agccgcggat tgtgactgcc
    11341 taagtggttc actttgagcc cttgaatagg tttcacgtat tcgggttcaa tcaaatgagt
    11401 ggttttatca atctttgcca aggttttaat cgcattgatg ataacagctg cagttggtcc
    11461 aaagagttca gatgttttac ctgtcacaat ctgcccattt ggtagttgga gagcaagggc
    11521 aggttggcct gtttgctctg ctttttgatg agcagctaca gtaacgtgac gatcgtcagg
    11581 ggtgacaccg atatcattca tcaagagctc aatttttttg acagcagatt ctgtgacccg
    11641 ctctgcctta aaatccacga gggtttggta ataacgacgg atgatttctt gtttagaagc
    11701 ttcgatagca gcttcttcat tgacgataga aaaaccaacc atgttaacac ccatatcggt
    11761 tggtgaggca taaggagact tgctcaaaat acgctcgaag gtccgattta agacaggaaa
    11821 gacctcgata tcacggttgt aattaacggc cgttttgcca taagtttcca aatggaaggg
    11881 gtcaatcata ttcacatcat ctaggtctgc cgtggctgcc tcataagcca gattgacagg
    11941 gtgatgaaga ggaagattcc aaactgggaa ggtttcaaat ttagcatagc cagacttaac
    12001 cccattgatt tggtcgtgat acatttggga catgcaagtg gctaattttc cagacccagg
    12061 gcctggtgct gtaacaacga taaggttacg actcgttttg atgtaatcat ttttccccat
    12121 cccctcagat gagataatat gattaatatc tgtcgggtag cccttgatag gataatgcag
    12181 gtaagaagca atgccatttt tttcgagttg cttgcgaaag gcatctgcag cgggttggtt
    12241 attgtattgg gtaataacga cagaacctac gtaaatatct aacgtgttaa atttgtcaat
    12301 taagcgaaag acttcttggt cataagaaat gcctaaatca ccacgcgctt tagaatgttc
    12361 aatattatta gcgttaatgg caattacaat ttcgacttgt tctttgagct ctttgagtaa
    12421 tttaatctta ttgtcaggtt catagccagg aagcacacgg gcagcatggt aatcttctaa
    12481 cattttacca ccaaattcca tgtaaagttt gccatcaaat tggctgatac gttctaaaat
    12541 atgatctctt tgcaagttta aatacttgtt agaatcaaaa gcaatagtct tcattttttc
    12601 acctctgtaa agcattataa caaagaaata ccaagaaaga aaaggttttt tgcagggata
    12661 cctcattttg tgacttttta aaaaaactta ggcttggttc ttagaagaaa aatgtatccg
    12721 ctatgttcaa aagaacttga caattaaaat gagctttact atactagtaa caattaaata
    12781 ctactttaaa catgttccgt gaagcatgaa agtcttaaca gtaaagagag tttttttgtc
    12841 atctcttatt atttagtgaa ctttgatgga cttgcggact tgtttccaag tctttttttg
    12901 acctttggac aaagggtatt caattaatta aggtagtcag tgagctacta ttaagaagga
    12961 gacaattatg tcaacattat cattggacac cacaaataag cgagctttag tggcagctat
    13021 tgcagcttca ggaacggatg acttgaatgt catgtttctt gccttttcca tgtcctccat
    13081 tatgacagac ttgggtctta gtggcactca gggtggctgg attgcgacca ttaccaattt
    13141 aggaatgttg gtgggaggcc tcttattcgg gttgctggct gataggcacc acaagtttaa
    13201 ggtctttaaa tggacgattt tactgttttc agtagcaaca ggattaattt attttaccca
    13261 gtctttgccc tacttgtact tgatgcgatt tattgctggc ataggagttg gaggtgagta
    13321 cggtatagcc attgctataa tggcagggat tgtaccacca gaaaaaatgg gtcggatgtc
    13381 ttctttaaat ggtattgctg gccagcttgg ctccattagt tcggctcttt tagcagggtg
    13441 gctggctcca agtctaggtt ggcgtggcct ttttctcttt ggattacttc cgattctctt
    13501 ggtgatttgg atgactttag ccatagatga ccaaaaaatt tgggatcatt atgggcaaga
    13561 ggaggaagaa tgcagtcaac caattaaaat caatgaacta ttcaaaacaa aatccttaac
    13621 agctcaaacc cttgctttaa tggtcatgac gactgtgcag attgcgggct attttggaat
    13681 gatgaattgg ttgccaacca ttattcaaac aagcttaaac ctttcagtaa aaagttcgtc
    13741 cttgtggatg gtggctacta ttgtcggcat gtgtttgggg atgctgtgtt ttggtcagct
    13801 tttagattgc tttggtccac gtctgattta ttccctcttt ttattagcat catctatttg
    13861 tgtttacctt tttcaatttg ccaattccat ggcgagtatg gttattggag gtgctattgt
    13921 cggttttttt gtcaatggga tgtttgctgg ctacggggct atgattacca gactttatcc
    13981 ccatcacatt cgatccacgg ctaataatgt tattttgaat gttggccgtg ctctaggagg
    14041 attttcgtcc gttgctattg gtagtatttt agatgcctca ggtatttcaa tggtcatgat
    14101 tttcctagct tctctgtatg tgattagttt tggagccatg tggactattg gtcagttaaa
    14161 agcagaacgc taccaacaat tgcgttagca aagagatggg tgttagtatt tgagttactt
    14221 tcactcacaa agctatttta ttgattgaga taatcaaaaa ggtaagtact tagggattgc
    14281 ttaccttttt gattcttttc ttttgtttta ttccgctact ttggccataa aatgtttact
    14341 gttcacccta actctagtat gacaggcttt tccaatgagt tgttctccca caaaagcttc
    14401 caagcggaaa tcgtattttc ggccttcttc tttaagggct gtaatgatga ttgtaacagg
    14461 atctccaatg gctgaagctg ccaaatgttg gatagctatc tcgctgccaa ccgttgtaaa
    14521 gtcactgtcg agctgttctt gggcaaataa gtaagaagca ttttccataa aagcaacaag
    14581 agcaggagta gctaggacat tcagcgttcc tgagcccatg gctttagccg aatgattggg
    14641 atgggtttca taagtgtgag aataaatagt cataagttaa tctcctcgtt tctataagcc
    14701 tattataata tattaagcgc ttacagtcat gaaaccactg tttttttatg ttatacttaa
    14761 taatgaattt tctttgaaag ggttatgatg cgtttagata aatttttagt ggcaactggt
    14821 gttggaacta ggagccaagt caaacttctc ttaaaaaaga aggctatctt cgtcaatcaa
    14881 aaggttgaaa cctctgccaa agcacacatt gatgaataca aggatttggt gacgtatcaa
    14941 ggcacgccct tggtctatga atcctttgtt tattacctgt taaacaagcc gtcagggtat
    15001 gtgtcggcaa cccaggacag acagcaggct actgttatgg agttgttaga tgacacggct
    15061 aggcaaaaaa cagtttttcc tgtgggtagg ttagataagg atacccgtgg acttttgctc
    15121 ttgaccaata atggacaact agcccatgac cttttatccc ctaaaaaaca tgttacgaaa
    15181 gagtacttgg ctaaagtagc aggcatcatg actgaagctg ataaagatta ttttgctaga
    15241 ggtatttcct taaaggatca ccagtgccta cctgctcatt tagaagtgct tgctagtgat
    15301 ttacagcagc aaacaagttt ggttaaaatt accatacaag aaggaaaatt ccatcaggtg
    15361 aaacgcatgg tagcagcctg tggaaaggaa gtgcttgact tgcagcgtct cagcatggga
    15421 ccattaaaac tagaccctag ccttgcagaa ggggagttta ggcgcctgac gcctgaggaa
    15481 ttgcagagcc tggcacctta ttgtcagagc tcactataaa aagaaacctc cccggtcagt
    15541 acacttgctc aatagttgcg aaatgagcat cattgacaag ctctcttttt aatgtt
//
LOCUS       DAUDWO010000043        15453 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.044, whole genome shotgun sequence.
ACCESSION   DAUDWO010000043 DAUDWO010000000
VERSION     DAUDWO010000043.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15453)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15453)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15453
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.044"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            21..1022
                     /locus_tag="VHC05_001465"
     CDS             21..1022
                     /locus_tag="VHC05_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEQ5402759.1"
                     /translation="MKKTLKSPLILLGLTLAIGASTQVDASSRSWKSWFIEKYFWLKG
                     DKGYYSEQDETKFDQYVNSSGEASNKGFDLKEEQVNGTLVTKTVDNMQVHTWNENPSN
                     KANQKVIFYLHGGSYLNNPTTYHIDMLKTLSTSLDAKIILPIYPKAPTYSYSDAMPKL
                     VDLYRDTLKETTAQNITIMGDSAGGGLALGLALALKNESLKQPKDIVLLSPWLDVTMS
                     NPDIESYESHDPILSAWGLRKVGEIWARRDPNNTKHPYVSPINGDVSGLAPITMFVGT
                     HEIFYPDVKKFDDILTAKGHQHELIVADKMNHVYPIYPIEEAKTAQYQIIDTIQKAY"
     gene            complement(1075..1425)
                     /gene="rbfA"
                     /locus_tag="VHC05_001466"
     CDS             complement(1075..1425)
                     /gene="rbfA"
                     /locus_tag="VHC05_001466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="HEQ5402760.1"
                     /translation="MANHRIDRVGMEIKREVNDILQKKVRDPRVQGVTITEVQMQGDL
                     SLAKVYYTIMSDLASDNQKAQTGLEKATGTIKRELGKQLTMYKIPDLVFEKDNSIAYG
                     NKIDQLLRELDKKD"
     gene            complement(1631..4492)
                     /gene="infB"
                     /locus_tag="VHC05_001467"
     CDS             complement(1631..4492)
                     /gene="infB"
                     /locus_tag="VHC05_001467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-2"
                     /protein_id="HEQ5402761.1"
                     /translation="MSKKRLHEIAKEIGKSSKEVVEHAKYLGLDVKSHASSVEEADAK
                     KIISSFSKASKPDVTASQTVKPKEVAQPSVTVVKETGSEHVEKTQVSKPKSRNFKAER
                     EARAKEQAARKQANGSSHRSQERRGGYRQPNNHQTNEQGDKRITHRSQGDTNDKRIDR
                     KASNVSPRHDNHQLVGDRNRSFAKENHKNGRFTNQKKQGRQEPQSKSPKIDFKARAAA
                     LKAEQNAEYSRQSETRFRAQQEAKRLAELARQEAKEAALKAQAEEMSHREAALKSIEE
                     AETKLKSSNISAKSTADNRRKKQARPEKNRELTHHSQEGQKKNKKSWNSQNQVRNQKN
                     SNWNKNKKTKKGKNVKNTNTAPKPVTERKFHELPKEFEYTEGMTVAEIAKRIKREPAE
                     IVKKLFMMGVMATQNQSLDGDTIELLMVDYGIEAKAKVEVDDADIERFFEDENYLNPE
                     NIVERAPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIEEAGKKITFL
                     DTPGHAAFTSMRARGASVTDITILIVAADDGVMPQTIEAINHSKAAGVPIIVAINKID
                     KPGANPERVIAELAEYGIISTAWGGECEFVEISAKFNKNIDELLETVLLVAEVEELKA
                     DPTVRAIGTVIEARLDKGKGAIATLLVQQGTLHVQDPIVVGNTFGRVRAMVNDLGRRV
                     KSAEPSTPVSITGLNETPMAGDHFAVYADEKAARAAGEERSKRALLKQRQNTQRVSLD
                     NLFDTLKAGEIKTVNVIIKADVQGSVEALAASLVKIEVEGVRVNVVHSAVGAINESDV
                     TLAEASNAVIIGFNVRPTPQARQQADTDDVEIRLHSIIYKVIEEVEEAMKGKLDPVYQ
                     EKVLGEAIIRETFKVSKVGTIGGFMVINGKVTRDSSVRVIRDSVVIFDGKLASLKHYK
                     DDVKEVGNAQEGGLMIENFNDLKVDDTIEAYIMEEIVRK"
     gene            complement(4512..4814)
                     /locus_tag="VHC05_001468"
     CDS             complement(4512..4814)
                     /locus_tag="VHC05_001468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003052320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxQ-related RNA-binding protein"
                     /protein_id="HEQ5402762.1"
                     /translation="MTNLERLSSLIGLAQRAGKVISGEELVVKAIQHQQVILVFLAND
                     AGPNVTKKVTDKSNYYNVEVSTVLNALELSAALGKPRKVAAIADAGFSKKMRTLME"
     gene            complement(4807..5103)
                     /locus_tag="VHC05_001469"
     CDS             complement(4807..5103)
                     /locus_tag="VHC05_001469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006531117.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxR family protein"
                     /protein_id="HEQ5402763.1"
                     /translation="MSKVKKIPLRKSLVSGEIIAKRDLLRIVKTKDGQVFIDPTGKQN
                     GRGAYIKLDNQEALMAKKKQVFNRSFSMDIPESFYDDLIAYVDHKIKRRELGLD"
     gene            complement(5119..6276)
                     /gene="nusA"
                     /locus_tag="VHC05_001470"
     CDS             complement(5119..6276)
                     /gene="nusA"
                     /locus_tag="VHC05_001470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusA"
                     /protein_id="HEQ5402764.1"
                     /translation="MSKEMLEAFRILEEEKHIDKADIIDAVTESLKSAYKRRYGQSES
                     CVIEFNEKTADFQVFTVREVVEEVFDSRLEISLKDALAISSAYELGDKIRFEESVNEF
                     GRVAAQSAKQTIMEKMRRQMREVMFNEYKEHEGEIMTGTVERFDQRFIYVNLGSLEAQ
                     LSHQDQIPGETFKSHDRIDVYVYKVENNPKGVNVFVSRSHPEFIKRIMEQEIPEVFDG
                     TVEIMSVSREAGDRTKVAVRSHNPNVDAIGTIVGRGGSNIKKVISKFHPKRVDAKTGL
                     EIPVEENIDVIQWVDDPAEFIYNAIAPAEVDMVLFDDEDLKRATVVVPDSKLSLAIGR
                     RGQNVRLAAHLTGYRIDIKSASEYDRLEAEKEAATVVEEPVVDDVMTAEEV"
     gene            complement(6451..6987)
                     /gene="rimP"
                     /locus_tag="VHC05_001471"
     CDS             complement(6451..6987)
                     /gene="rimP"
                     /locus_tag="VHC05_001471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimP"
                     /protein_id="HEQ5402765.1"
                     /translation="MDSQGPIILEKSIKIEEVIKIAITSIIDIVTKTVTPEIKAPYEL
                     VDVEYDKMGSDYILSILVDKEGGITVEDTSDLTNIISPLLDTIDPDPFPNQYMLEVSS
                     PGLERPLKTADSLKAAVGSYINVSLYQAIDKVKVFQGDLLAFDGETLTIDYLDKTRHK
                     IVNIPYQAVAKVRMAVKL"
     gene            complement(7095..7181)
                     /locus_tag="VHC05_001472"
     tRNA            complement(7095..7181)
                     /locus_tag="VHC05_001472"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(7145..7147),aa:Ser,seq:gga)
     gene            complement(7246..7881)
                     /gene="trmB"
                     /locus_tag="VHC05_001473"
     CDS             complement(7246..7881)
                     /gene="trmB"
                     /locus_tag="VHC05_001473"
                     /EC_number="2.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012679098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="HEQ5402766.1"
                     /translation="MRVRKRKGAEEHLANNPHYVILNPEDAKGRWHDVFGNDRPIHIE
                     VGSGKGGFITGMALKNPDINYIGIDIQLSVLSYALDKVLASEVPNVKLLRVDGSSLTN
                     YFEDGEVDMMYLNFSDPWPKTKHEKRRLTYKDFLDTYKRILPEHGEIHFKTDNRGLFE
                     YSLASFSQYGMTLRQIWLDLHASNYEGNVMTEYEEKFSNKGQVIYRVEANF"
     gene            complement(7881..8672)
                     /locus_tag="VHC05_001474"
     CDS             complement(7881..8672)
                     /locus_tag="VHC05_001474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphotransferase family protein"
                     /protein_id="HEQ5402767.1"
                     /translation="MTTTEQELTLTPLRGKSGKAYKGTYPNGECVFIKLNTTPILPAL
                     AKEQIAPQLLWAKRMGNGDMMSAQEWLNGRTLTKEDMNSKQIIHILLRLHKSKKLVNQ
                     LLQLNYKIENPYDLLVDFEQNAPLQIQQNSYLQAIVKELKRSLPEFKSEVATIVHGDI
                     KHSNWVITTSGMIFLVDWDSVRLTDRMYDVAYLLSHYIPRSRWSEWLSYYGYKNNDKV
                     MQKIIWYGQFSHLTQILKCFDKRDMEHVNQEIYALRKFREIFRKK"
     gene            complement(8736..9770)
                     /locus_tag="VHC05_001475"
     CDS             complement(8736..9770)
                     /locus_tag="VHC05_001475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402768.1"
                     /translation="MKALFLKRRQDFQKQQNKYLRYVLNDHFVLVLMFLLGFAMVQYG
                     QLLNHFPTNHLPIQVCLGILIPLLLSMGSIATYLEEADQHFLLPKEEEVISYIKQAER
                     LSFLLWGTLQTAVLLFLYPIFRRLGLSLFIFIILVLILLALKRVVLSRKTRYFLRGNR
                     LDWAKAVAFESNRKQSILKFYSLFTTVKGISTKVKERTYLNPLLKLVKQTPSNLWLSL
                     YARAFLRSSDYLGLFLRLMLLSSLSVFFIHNLYLSVSLALIFNYLVVFQLLSLYYHYD
                     YHYMTSLYPENSRSKKKNMLSFLRGLSFLMLIVNMLCCSSAPKALILIVGMVFIACIY
                     LPYKLKKIID"
     gene            complement(9773..10498)
                     /locus_tag="VHC05_001476"
     CDS             complement(9773..10498)
                     /locus_tag="VHC05_001476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402769.1"
                     /translation="MLNIKNLTGGYHNIPVLNDVSFSVDNGELVGLIGLNGAGKSTTI
                     NEIIGFLKPYQGSISIDGLTLAENAVAYRQKIGFIPETPSLYEELTLSEHINTVAMAY
                     DIDLEVAQKRAQPFLEMFRLTDKLEWFPVNFSKGMKQKVMIICAFVIDPSLFILDEPF
                     LGLDPLAISDLIQTLEVEKAKGKSILMSTHVLDSAERMCDRFVILHHGQVRAQGTLAD
                     LQEAFGDRSASLNDIYLALTKED"
     gene            10570..10989
                     /locus_tag="VHC05_001477"
     CDS             10570..10989
                     /locus_tag="VHC05_001477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HEQ5402770.1"
                     /translation="MENCIFCSIIQGDIPSSKVYEDEQVLAFLDISQTTKGHTLVIPK
                     QHVRNLLEMTAETASHLFARIPKIARAIQSATGATAMNIINNNEALAGQTVFHAHVHL
                     VPRYNEEDGISIQYTTHEPDFPVLEKLARQINQEVSS"
     gene            10986..11342
                     /locus_tag="VHC05_001478"
     CDS             10986..11342
                     /locus_tag="VHC05_001478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein"
                     /protein_id="HEQ5402771.1"
                     /translation="MKVETVIAVGLLSFTAYKAYQKRCTIKELLSISRQAKDAAQLDL
                     DNIKANLDLIHSQGKVIQNISQDLAHKWRYFNQETQAHLTEIQNRMAKYQEDSELISS
                     ESPTCQTVILTNNHSR"
     gene            complement(11453..12736)
                     /locus_tag="VHC05_001479"
     CDS             complement(11453..12736)
                     /locus_tag="VHC05_001479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HEQ5402772.1"
                     /translation="MKIGKKIVLMFTAIVLTTVLALGVYLTSAYTFSTGELSKTFKDF
                     STSSKKSDAIKQTRAFSILLMGVDTGSSERASKWEGNSDSMILVTVNPKTKKTTMTSL
                     ERDTLTTLSGPKNNEMNGVEAKLNAAYAAGGAQMAIMTVQDLLNITIDNYVQINMQGL
                     IDLVNAVGGITVTNEFDFPISIAENEPEYQATVAPGTHKINGEQALVYARMRYDDPEG
                     DYGRQKRQREVIQKVLKKILALDSISSYRKILSAVSSNMQTNIEISSRTIPSLLGYRD
                     ALRTIKTYQLKGEDATLSDGGSYQIVTSNHLLEIQNRIRTELGLHKVSQLKTNATVYE
                     NLYGSTKSQTVNNNYDSSGQAPSYSDSHSSYANYSSGVDTGSSYQSASTDQDSTASSH
                     TPTTPSSSSDALAADESSSSGSGSLVPPANINPQT"
     gene            complement(12745..13269)
                     /locus_tag="VHC05_001480"
     CDS             complement(12745..13269)
                     /locus_tag="VHC05_001480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEQ5402773.1"
                     /translation="MIQQSLVIEEGVPQDAKAVLSLVTAAAKETDFITGVETILEATP
                     QELSDFLSRSQTSFIDFCLLARLDEKVVGLLNLSGEVLSQGQVEADVFMLVAKTYRGY
                     GIGQLLLEIALDWAEENPYIESLKLDVQVRNTKAIYLYKKYGFRIESMRKNDIKSKNG
                     DDLDIYHMRKSVSQ"
     gene            complement(13244..13705)
                     /gene="tsaE"
                     /locus_tag="VHC05_001481"
     CDS             complement(13244..13705)
                     /gene="tsaE"
                     /locus_tag="VHC05_001481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="HEQ5402774.1"
                     /translation="MFYSENEYTLKAYGETLGTYLSIGDVIVLSGDLGAGKTTLAKGI
                     AKGMGISQMIKSPTYTIVREYEGRLPLYHLDIYRVGDDPDSIDLDDFLFGNGVTVIEW
                     GELLGEGLLQDYLQITITKRDKGRQLDLLAHGERSRQLLEIMSHDSAKSRY"
     gene            complement(13859..15319)
                     /locus_tag="VHC05_001482"
     CDS             complement(13859..15319)
                     /locus_tag="VHC05_001482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HEQ5402775.1"
                     /translation="MEKFFKLSENGTTVSTEIMAGLTTFFAMSYILFVNPSILGAAGM
                     PSNAVFLATIIAAAISTLIMGLFANVPYALAPGMGLNAFFTYTVVFALGFSWQEALAM
                     VFICGLFNIFITVTKFRKSIIKAIPVSLQHAIGGGIGVFVAYLGFKNANIITFSISAE
                     NIVMVNGVEPAKASAKTFADGLLFVDANGGVVPTISSFTDSSVLLAIFGLLLTTALVI
                     RNFRGAILIGIVATTLVGIPLGIVDVSNLNFGISHIGEAWTELGTTFLAAFDGLSSLF
                     SDSSRLPLVFMTIFAFSLSDTFDTIGTFIGTGRRTGIFSQDDENALENSIGFSSKMDR
                     ALFADAIGTSIGALVGTSNTTTYVESAAGIAEGGRTGLTAVSTAVCFLLSILLLPLVG
                     IVPAAATAPALIVVGVMMVSSFLDVNWSKFADALPAFFAAFFMALCCSISYGIAAAFI
                     FYCLVKVVEGKTKDIHPIIWGATFLFIVNFIILTIL"
BASE COUNT         4789 a         3209 c         2623 g         4832 t
ORIGIN      
        1 gtaataataa ggagaactca ttgaaaaaga cacttaaaag ccctcttatt ttactaggac
       61 ttactctagc aataggagct agcactcaag ttgatgccag ttctagatct tggaaaagct
      121 ggtttataga gaaatacttt tggttaaaag gagacaaagg ctattattca gagcaagacg
      181 aaactaagtt tgatcaatat gtcaactctt ctggagaagc ttcaaataaa ggctttgatc
      241 ttaaagaaga acaggtaaat ggcacattag tcactaaaac tgttgataat atgcaagttc
      301 atacttggaa tgagaacccc agcaataaag ccaatcaaaa ggtcattttc tatttacatg
      361 ggggctctta cctaaacaac ccaactactt atcatatcga catgctaaaa accttatcaa
      421 ctagtcttga tgctaagatt atcttaccaa tctatccaaa agcacctact tactcttaca
      481 gtgatgctat gccaaaattg gttgaccttt acagagatac tcttaaagaa acaactgcac
      541 aaaatatcac tattatgggt gattcagcag gtggtggact agcgcttggt ttagcattag
      601 ccctaaaaaa tgaaagttta aaacaaccaa aagacattgt tctcttatca ccatggttag
      661 atgtaaccat gtcaaatcca gatattgaga gctatgaaag tcatgatccc attctttcag
      721 cttggggcct acgtaaagtt ggggaaattt gggcacgccg tgacccaaac aacaccaaac
      781 atccatatgt tagtccaatt aatggagatg tatcagggct agcacctatt actatgtttg
      841 ttggtacaca tgaaattttc tacccagatg ttaagaaatt tgatgatata ttaactgcca
      901 aaggtcatca acatgaactt atcgtcgctg ataaaatgaa tcatgtttac ccaatctatc
      961 caattgaaga agccaagact gcacaatatc aaatcattga tacgattcaa aaagcttact
     1021 aaaaacaaaa aacccttaag gtgactctaa taagatacct taaaggtttt taatttaatc
     1081 ttttttatca agctcacgta agagttgatc aattttatta ccataggcga tggaattgtc
     1141 tttttcaaac accaaatctg gaattttgta catggtcaat tgtttgccaa gttcacgttt
     1201 aatcgttcca gtcgcttttt caagccctgt ttgtgctttt tgattatcag atgccaagtc
     1261 actcataata gtgtaataaa ctttagcaag tgacaagtca ccctgcattt gcacttctgt
     1321 aatcgttact ccctgaacgc gtggatcacg cacttttttc tgaagaatat catttacttc
     1381 gcgcttgatt tccatcccaa cgcggtcaat acgatgatta gccatagcca tttcctttcc
     1441 acatttttaa aacaaaagct aggctgaaag cccagcttat gacattgcta cctgttttga
     1501 taacgacaat taaagggaat ctgagaattc catgacgaga ctggaaggaa tgccccaact
     1561 agctcatctg gtagaaaaag tcattatttt cgacagagga aaaacgtcac atctcagacc
     1621 ttcttagccc ctattttctc acaatttctt ccataatata ggcttcaata gtatcatcaa
     1681 ctttaagatc gttaaagttt tcaatcatca acccaccttc ttgagcatta ccgacttctt
     1741 taacgtcatc tttgtaatgt ttcaagctgg ccagtttacc atcaaaaata acgacactat
     1801 cacggataac acgaacactc gaatcacgtg tcaccttacc gttgattacc ataaagccac
     1861 caattgttcc cactttagaa actttgaagg tttcacgaat aatagcttca ccaagaactt
     1921 tttcttggta aacagggtca agtttccctt tcatggcttc ttctacttct tcaatgactt
     1981 tatagataat gctatgaaga cgaatttcca catcatccgt atctgcttgt tgacgagcct
     2041 gtggggtagg gcgaacgttg aaaccgataa taacagcatt tgatgcttca gcaagggtca
     2101 catcagactc attgatagca cctacagcag agtgaacgac attgacacgg acaccttcca
     2161 cttcaatctt tacaagagat gctgcaaggg cttcaacaga accttgaacg tctgctttga
     2221 tgatgacatt aacagtcttg atttctcctg ctttaagggt atcaaagaga ttatcaaggc
     2281 taacacgctg tgtattttga cgttgtttga ggagggcacg ttttgatcgc tcctcaccag
     2341 ctgcacgcgc agctttttca tcagcgtaaa cagcaaagtg atcaccagcc attggtgttt
     2401 cgttcaaacc agtaatggaa actggtgttg atggctccgc agatttaaca cgacgcccaa
     2461 ggtcatttac catggcacgg acacgaccaa aggtattacc aacaacgatt ggatcttgaa
     2521 catgaagagt tccttgttgg acaagaagcg tagcgatagc acctttacct ttatctaagc
     2581 gtgcttcaat tacagtacca atagcacgaa ccgtcggatc agctttcaat tcttccactt
     2641 cggcaaccaa aaggactgtt tctaatagtt catcaatatt tttattaaat ttagcagata
     2701 tctctacaaa ttcgcactct ccgccccaag cagttgagat gataccatat tctgccaatt
     2761 ctgcgataac acgttctgga ttagcacctg gtttatcaat tttgttgata gcaacaataa
     2821 ttggaacacc agcagctttt gagtgattga tcgcttcaat cgtttgtggc ataacaccat
     2881 catcagctgc aacaatcaaa atggtgatat cggtaacgga agctccacgt gcgcgcatgc
     2941 ttgtaaaggc cgcgtgtccg ggagtatcca agaaggtaat tttcttgcca gcttcttcaa
     3001 tctggtaagc accaatatgc tgagtaattc ctccagcttc tcctgttgcc acacgtgagt
     3061 tacgcaaagt atcaagcaaa gttgtcttac cgtggtctac gtgtcccatg atagttacaa
     3121 caggtgcgcg ttctacaata ttttcaggat tgaggtaatt ttcatcctca aagaagcgct
     3181 cgatatcagc atcatctact tctaccttag ccttagcctc aataccataa tctaccatca
     3241 ataattcgat agtatcccca tctaaagact ggttttgagt tgccataaca cccatcataa
     3301 acagcttttt gacaatttca gcgggttcgc gtttgatacg ttttgcgatt tcggcaactg
     3361 tcatgccttc agtatattca aattcttttg gcaattcatg gaatttacgc tcggttactg
     3421 gttttggagc ggtgttggta ttcttaacat ttttgccttt tttggtcttt ttatttttat
     3481 tccagttact atttttttga tttctcactt ggttttgact attccaactc ttcttatttt
     3541 tcttttgccc ttcttgtgaa tgatgagtta actcacgatt cttttcagga cgtgcttgtt
     3601 ttttacggcg attatcagca gtagatttag cactaatatt tgatgacttt aatttagttt
     3661 ctgcttcttc aatagatttc agtgctgctt cacgatggct catctcctca gcttgtgctt
     3721 ttagagccgc ttctttagct tcttgtcttg ccaactcagc taaacgctta gcttcttgct
     3781 gtgcacgaaa acgtgtttca ctttggcgtg agtattcagc attttgttca gcttttaagg
     3841 cagcagcacg agctttgaaa tcaattttag gacttttcga ttgaggctct tgtcgtcctt
     3901 gctttttttg gtttgtgaat cgaccattct tgtgattctc cttagcaaag gaacggttac
     3961 gatcaccaac tagctgatga ttatcatgtc taggtgatac attcgatgct tttcggtcaa
     4021 tacgcttatc gtttgtatca ccttgagaac gatgggtaat cctcttatct ccttgttcgt
     4081 tagtttgatg attattgggc tggcgataac ctcctcgacg ttcttgagaa cgatgagaag
     4141 agccatttgc ttgttttcga gcagcctgtt cctttgcacg agcctctctt tcagctttaa
     4201 aattacgact ctttggctta gagacctgtg ttttctctac atgctcagaa cctgtttctt
     4261 tgaccactgt tacagagggt tgagcaactt ctttgggttt gactgtttga gaagctgtca
     4321 catcaggttt agaagccttt gaaaaacttg aaataatctt tttcgcatcc gcttcttcaa
     4381 cacttgatgc atggcttttc acatctaatc ctaagtattt agcgtgttca accacctctt
     4441 tactactttt accaatttcc ttggcaattt catgtaatct tttctttgac aatttgtgtc
     4501 ctcctattca tctattccat aagagtcctc attttctttg aaaatccagc atctgcaatg
     4561 gcagcaacct tccttggttt acctagtgca gcacttaatt ccagtgcatt caacactgtg
     4621 gagacttcta cattataata attactttta tctgtcactt tttttgtcac attaggacca
     4681 gcatcattgg ctaaaaatac taatattacc tgctggtgtt gaatagcttt tactactagt
     4741 tcttcacctg aaatcacttt tccagcccgt tgagctagac caataagact agataatctt
     4801 tctaaattag tcaagaccta actctcttct tttgattttg tgatcaacat aagcaatcaa
     4861 gtcatcgtaa aaactttctg gaatgtccat tgagaaactc ctgttgaaaa cttgtttttt
     4921 cttggccatt aaggcctctt gattgtctaa tttgatataa gcaccacgac cattttgttt
     4981 accagttgga tcaatgaaaa cttgaccatc cttagttttt acaatcctaa gaagatctcg
     5041 tttagcaata atttcaccag aaacaagtga ttttcgtaaa ggtatttttt tgactttaga
     5101 catcaaacac ctcttttctt acacttcctc ggcagtcata acatcgtcaa caactggctc
     5161 ttccacaact gttgctgctt ctttttccgc ctcaagacga tcatattcgc tagctgattt
     5221 gatatcaata cggtagccag tcaaatgtgc cgctaaacga acgttttggc cgcgacgccc
     5281 gatagctaat gataatttgc tatcaggaac tactaccgta gcacgtttaa gatcttcatc
     5341 gtcaaaaagt accatgtcta cttcagccgg agcaatggca ttgtagatga actcagctgg
     5401 atcatctacc cattgaatca cgtcaatatt ttcttcaact ggaatttcaa gccccgtctt
     5461 agcatctaca cgttttggat ggaacttgct gatgaccttt ttaatattac ttccaccacg
     5521 tccaacaatt gttccgatgg catcaacgtt aggattatga ctgcgcacag caaccttggt
     5581 acggtcacct gcttcacgag agacactcat gatttcaaca gtaccatcaa agacttcagg
     5641 aatttcttgc tccataatac gtttgatgaa ttctggatgg ctacgactaa caaagacgtt
     5701 aactccttta ggattatttt caactttgta gacataaacg tcaatacggt catgtgattt
     5761 gaaagtttca cctggaatct ggtcttggtg agacaattgt gcttctaagg aaccaagatt
     5821 gacataaata aaacgttgat caaaccgttc aactgttcct gtcataattt caccttcatg
     5881 ctctttgtat tcattgaaca tcacttcacg catttggcgg cgcatctttt ccataatagt
     5941 ctgcttagct gattgagctg cgacacgtcc aaattcattg acagattctt caaagcgaat
     6001 cttatcacct aattcatagg cagaactgat agcaagagca tctttcaaac taatctcaag
     6061 ccggctgtca aaaacttctt caacaacctc acgaaccgtg aatacttgaa aatcagctgt
     6121 tttttcatta aattcaataa cacatgattc tgattgacca tagcgacgtt tataggcaga
     6181 ctttaatgat tctgtcactg cgtcaataat atctgcttta tcaatgtgtt tttcttcttc
     6241 caaaatacgg aaggcttcta gcatttcttt gctcataatg ttatctacct tgcttgtaaa
     6301 gcttggcaaa aatcctttct taaattaata cgatcaatag ccccctaaag gctcccttaa
     6361 ttccttttgt ttagcttgta taaactctat aggtgttgtt tcaaatttgc ttaagcgttc
     6421 ctaaaaaagt ttagtgcttc gaaataaaag ttataatttg acagccattc tcaccttagc
     6481 aactgcttga tatggtatat tcacgatctt atgacgtgtt ttatcaagat aatcaatggt
     6541 caacgtttca ccatcaaagg ctaataagtc tccttgaaaa actttcacct tatcaatagc
     6601 ttgataaaga ctcacattga tataagagcc aactgctgct tttaaactgt cagctgtctt
     6661 aagcggacgc tccaaacctg gactagagac ttctagcata tattggtttg gaaaaggatc
     6721 tggatcaatc gtatctaaca gcggactaat aatattcgtc aagtcagatg tatcttccac
     6781 tgtgattcca ccttccttat cgactaaaat actaaggatg tagtcactac ccattttgtc
     6841 atattcaacg tctactaatt cataaggtgc cttaatctca ggtgttactg tcttggttac
     6901 gatatcgata atagatgtaa ttgctatttt gattacctcc tctattttta tgctcttctc
     6961 taagataatt ggtccttggg aatccactta atacaaaagt ggcgagacat atcccaccac
     7021 ctttctgtat tatttaagcc tattatacca taatttaaga ggaatgcaag gatatgcact
     7081 ttgttttact cacaaggaga ggaggggatt cgaacccccg agccccgtta aggactacac
     7141 gctttccaag cgtgcgcact aagccactat gcgacctctc cattactaaa gaagttaata
     7201 ctgtatcaac tcctttatgt tatcatattt tggaacaaaa tactactaga aatttgcctc
     7261 aactcggtaa atgacttgac ctttattaga gaacttctct tcatattctg tcatgacatt
     7321 tccttcatag ttactagcgt gtaagtcaag ccagatctgt ctcaaggtca tgccgtattg
     7381 agaaaaacta gctaaactgt actcaaacaa gccccgatta tcggttttaa aatgaatttc
     7441 accgtgttct ggcaagatac gcttgtaagt gtctaagaaa tccttgtagg tcaaacgacg
     7501 tttttcatgc ttggtttttg gccaaggatc tgaaaagttg agatacatca tatccacctc
     7561 accatcttca aaatagttgg ttaaacttga tccatccact cgcagaagtt tgacattggg
     7621 tacttctgaa gctaatacct tatccaaggc gtagcttagg acagataatt gaatatcaat
     7681 gccaatgtag ttaatatcag gatttttcaa ggccatccct gtgataaatc cgccctttcc
     7741 tgaaccaact tcgatatgaa taggacggtc atttccaaaa acgtcatgcc aacggccctt
     7801 ggcatcttct ggatttaata tcacatagtg tgggttatta gctaagtgct cctcagcacc
     7861 ttttcgtttt ctaactcgca ttatttcttt ctaaatattt ctctaaattt tctgagggca
     7921 taaatctcct gattcacatg ctccatgtca cgcttgtcaa aacacttgag aatttgtgtc
     7981 aggtgagaaa attgaccata ccaaataatt ttttgcataa ccttgtcatt atttttatag
     8041 ccataataag acagccattc tgaccaacga gaccgtggaa tatagtggct caacaggtaa
     8101 gcaacatcat acatccgatc agtcagacga acagaatccc aatctactaa aaaaatcata
     8161 ccactagtag taatcaccca attgctatgt ttaatatctc catgcacaat cgttgctact
     8221 tctgatttga actctggtaa gctccgtttt aattctttaa cgatagcttg taagtatgaa
     8281 ttttgctgaa tttgcaaggg tgcattttgc tcaaaatcaa ccaataaatc gtatgggttt
     8341 tcaatcttat aattgagctg aagcagttga ttgactaatt ttttagattt gtgaaggcgc
     8401 aatagaatat gaatgatttg cttactgttc atatcttctt tggtcaatgt acggccgtta
     8461 agccattctt gggcactcat catatcacca ttgcccatgc gtttggccca aagtaactgt
     8521 ggcgcaatct gttcttttgc taaggcaggt agaatagggg tcgtatttaa ttttataaag
     8581 acacattccc cgtttggata agtgccttta taagctttgc cacttttccc acgtaaggga
     8641 gtcaaggtaa gttcttgttc cgtcgttgtc accttatcgc cctccttttc tatcttttat
     8701 agtcgtttac ccctatttta cttgttttag gctacttagt caatgatctt ctttaactta
     8761 taaggtagat atatacaagc tatgaaaacc atacctacaa tcaaaatgag tgcttttggc
     8821 gctgatgagc aacacagcat attgacgatt aacattaaaa agcttaaacc tcgtaaaaaa
     8881 cttaacatat ttttcttctt gctccgacta ttttcaggat aaagactagt catataatgg
     8941 taatcgtagt gataataaag tgaaagtaat tggaatacaa ctaaatagtt aaaaatgagt
     9001 gctaaactta ctgacaaata aagattatgg ataaaaaata cagataatga gcttaatagc
     9061 attagtcgta aaaataagcc caaataatct gaactacgta aaaaggctct agcataaagg
     9121 gacagccaaa ggtttgaagg agtttgctta actaatttta aaagaggatt tagataagtt
     9181 ctttctttca cttttgtaga aattcctttg actgttgtaa aaagagaata aaactttaaa
     9241 atactttgct tgcgattgct ttcaaatgcg acagcttttg cccaatctaa acgatttcct
     9301 ctcaaaaaat atcttgtctt tcgactaagc actactcttt ttagtgccaa taatatcaaa
     9361 actaagataa taaaaataaa taaagacaga cctaaacgtc taaaaatagg atataaaaag
     9421 agcaatacag cagtctgcaa agttccccaa agcaaaaaag agagtcgctc agcttgtttg
     9481 atataagaaa tcacttcttc ttcttttgga agtaagaaat gctgatctgc ctcttctaga
     9541 tacgttgcta tagatcccat actgagcaat aatgggatca atatcccaag acaaacctga
     9601 ataggtagat gattcgttgg aaaatggttt agtagctgac catactgcac catagcaaag
     9661 cctaataaaa acatcaacac caaaacaaag tgatcattta agacgtaacg aaggtatttg
     9721 ttttgttgtt tttgaaagtc ttgacggcgt ttcagaaata atgctttcat acttaatcct
     9781 cttttgttaa tgcaagatag atatcattta agctcgctga acggtcacca aaagcttctt
     9841 gcaagtcagc aagagttcct tgggcacgaa cttgtccatg atgcaaaatc acaaaacgat
     9901 cacacattct ttcagcagag tccaaaacat gtgtactcat caaaatagat tttccttttg
     9961 ctttttcgac ttctagcgtt tggattaagt ctgaaatagc taaagggtct aaccctaaga
    10021 atggttcatc aagaataaat agacttggat caatgacaaa ggcacaaata atcatgactt
    10081 tttgtttcat ccctttagaa aaattgacag gaaaccattc aagtttgtca gttaaacgaa
    10141 acatttccaa gaaaggttgt gctcgttttt gtgccacttc taagtcgata tcataagcca
    10201 tagctacggt gttgatatgc tctgataagg tcaattcttc atagagacta ggagtttctg
    10261 ggataaaacc tattttttga cggtaggcaa ctgcattttc tgctagagtt aaaccatcaa
    10321 tagaaatact tccttgataa ggcttcaaaa agccaataat ttcgttgata gttgttgact
    10381 ttccagcacc atttagcccg atcaaaccga ctaactctcc attgtctaca gaaaatgaga
    10441 catcgtttaa aacagggata ttgtgatatc ctcctgttag atttttaatg tttaacatat
    10501 aatttctttc tagtttttga tatacttata atatattata acaaattcaa gtagagaagg
    10561 tgatataaaa tggaaaattg tattttttgc agcatcattc aaggggatat cccctcttcg
    10621 aaagtctacg aagatgagca ggtcctcgcc tttttagata tctcacaaac tacaaaaggg
    10681 catactctag tcattcctaa gcaacatgtt cgtaacttac tagagatgac tgctgagaca
    10741 gctagtcatc tctttgctcg tattcctaaa attgctcgtg ctatccagtc agctactggc
    10801 gctactgcca tgaatatcat taacaataac gaagccttag cgggacaaac tgttttccat
    10861 gctcatgttc atctcgttcc tcgttataat gaagaagacg gtatctcaat tcaatacacc
    10921 actcatgagc ctgactttcc tgtcttggaa aagctcgccc gacaaatcaa tcaggaggtt
    10981 agttcatgaa agttgaaacc gtgatagccg tcggattatt atcttttacc gcttacaaag
    11041 catatcaaaa acgttgtacc ataaaagagc tgttatccat cagtagacaa gcaaaagatg
    11101 ctgcccaact tgatttagat aacattaaag caaaccttga cctcattcac agtcaaggaa
    11161 aagtaattca aaatattagt caggacttgg cccataaatg gcgctacttt aaccaagaga
    11221 cacaagcaca cctcactgaa atccaaaatc gtatggccaa atatcaagaa gatagtgagc
    11281 taatttctag tgaatcacct acttgccaaa ccgtcatttt aactaacaac cattccagat
    11341 agtattatct ccctcatata ctttatttga aatcacagac agctatcatc tttgatacct
    11401 gtctttttta tattcaaaat cggatatttt aaacataaaa accctcagaa cgttaggtct
    11461 gagggttgat attagcagga ggaactaatg atccagaccc tgatgagcta gactcatcag
    11521 ctgctaaagc atctgatgaa gaagacggcg tagttggcgt atggcttgaa gcagtagagt
    11581 cctggtctgt actagcactc tgataagatg agccagtatc tactccactt gaataattag
    11641 cgtaagagct atgactatca gaataagatg gagcctggcc tgaagagtca tagttgttgt
    11701 ttactgtctg agacttagtt gacccataca aattttcata aacagtagca tttgttttta
    11761 attgactaac cttatgaagt cctaattctg ttcggatacg attttggatt tctaacaaat
    11821 gattagaggt aacaatttgg tatgatccac catctgataa agtggcatct tctcctttta
    11881 gttgataagt cttaatagtt ctaagtgcgt cacgataacc taatagacta gggatagtgc
    11941 gagaagagat ttcgatattc gtttgcatat tactacttac agcagataaa atcttccgat
    12001 aagagctaat gctatcaaga gcaaggattt ttttcaatac cttttgaatg acttcacgtt
    12061 gacgcttttg tcgaccataa tctccctcag gatcatcata acgcatacga gcataaacca
    12121 aagcttgttc accgttaatt ttgtgtgttc caggcgcaac agtagcttga tattcaggtt
    12181 cgttttcagc aatcgagata ggaaaatcaa actcatttgt aactgtaatc cctccaactg
    12241 cattcacaag atcaataagg ccttgcatat taatttgaac atagttatca atggtgatat
    12301 tcaaaagatc ttgcacggtc ataatagcca tctgagcgcc acctgctgca taagcagcgt
    12361 taagcttagc ttcaacacca ttcatttcat tatttttggg tccagataac gtggttaagg
    12421 tatctcgttc taaactagtc atagttgttt tcttggtctt tggattaacc gtaaccaaaa
    12481 tcatcgaatc actgtttcct tcccacttgg aggcacgctc tgaagagcct gtatcaacac
    12541 ccatcaacaa gatagaaaaa gctcttgttt gtttaatggc atcacttttc tttgaagatg
    12601 tcgaaaaatc tttaaaggtc tttgataatt ctcctgttga gaaggtataa gcactagtta
    12661 gatagacacc taatgccaag acagttgtta acacaatagc tgtgaacatt aaaactattt
    12721 tttttccaat tttcatcgat tcacttactg acttacagat ttacgcatat gataaatatc
    12781 taagtcatct ccattttttg atttgatgtc gttttttcgc atactttcaa tacgaaaacc
    12841 atacttttta tacaggtaaa tagccttagt atttcttact tgaacgtcca acttaaggct
    12901 ttcgatataa gggttttctt cagcccaatc aagagcaatc tctaacaata attgaccgat
    12961 accataacca cggtaagtct tagcaactaa cataaataca tctgcttcaa cttggccttg
    13021 ggataatact tccccagaaa gatttaaaag ccctactact ttttcatcta atctagctag
    13081 caggcaaaaa tcaataaaag aggtttgact tcttgataaa aagtctgaca attcttgagg
    13141 agtagcctct aatatagtct ctacgcctgt tataaaatct gtttctttgg cagctgccgt
    13201 cactaaggaa agtacagctt ttgcatcttg aggtacgcct tcttcaataa cgagactttg
    13261 ctgaatcatg tgacattatc tccagaagct gacgagagcg ctcaccatgc gctaacaagt
    13321 ctagttgacg acctttgtct cgtttagtaa tggtaatttg caaatagtct tgtaataatc
    13381 cctctcctaa taattctccc cactcaataa cggtaacacc attaccaaaa agaaaatcat
    13441 ctaaatcaat agagtctgga tcatcaccaa cacggtaaat atctaagtga taaagaggta
    13501 gacgtccttc atattctcta acaatagtat aagttgggct tttgatcatt tgactaatcc
    13561 ccatcccttt agcaatacct tttgccaatg ttgttttacc ggcacctaag tcgccagaca
    13621 atacaatcac atctccaata gacaaataag tacctagggt ttctccgtaa gctttaagag
    13681 tatattcatt ttcactataa aacatagcaa cattatatca gaaaaaaaac atacttccaa
    13741 gcactaccta gaagatgact caaataaggt attcgtaaag taaaaacgct tctttatatt
    13801 aaaggttaaa atcaattaaa gaagcggcag ttagtagcaa aataagtaaa ttatttggtt
    13861 ataagatagt taatatgatg aagtttacaa tgaacaagaa ggttgctccc caaataatag
    13921 ggtgaatatc ttttgttttt ccctcaacaa cttttactag acaataaaaa ataaaggcag
    13981 cggcaatacc ataggaaata gagcaacaca gcgccataaa gaaagctgca aaaaaagctg
    14041 gaagagcatc tgcaaattta ctccaattaa catcaagaaa agaagacacc atcatgacac
    14101 ccacaacaat taaagctgga gccgtagcag cagctgggac aatacctaca agcggtaata
    14161 gcaatattga taataagaag catactgcgg tggagactgc tgttagtcca gtacgtccac
    14221 cttcagcaat tcctgctgct gattcaacat aggtagtcgt atttgaagtt ccaaccaaag
    14281 ccccaataga agtaccgata gcatctgcaa aaagcgcacg atccattttt gaactaaagc
    14341 ctatactatt ttccaaagca ttctcatcgt cttgagagaa aatacctgtt cgacgaccag
    14401 ttccgataaa ggtaccaatt gtgtcaaaag tatctgatag actaaaagca aaaatagtca
    14461 tgaaaactag cggtaaacga cttgaatcgc taaaaagaga actcaaacca tcgaaagctg
    14521 caaggaaagt tgtacctaat tcagtccaag cttcaccaat atggctgatc ccaaaattga
    14581 ggttggacac atccactatt cctaaaggaa tacctacaag agttgttgcg acaataccaa
    14641 ttaaaatagc acctctaaaa tttcgaatca caagagctgt cgttaaaagt aaaccaaaaa
    14701 tagcaagtaa tacactagaa tccgtaaaac tagaaatcgt aggtacaact ccaccattgg
    14761 cgtctacaaa taatagacca tctgcaaatg ttttagccga tgctttagcc ggttcaacac
    14821 catttaccat tactatattt tcagcagaga tagaaaaagt aatgatattt gcgtttttaa
    14881 atcctaaata agctacaaag acaccaattc ccccaccaat agcatgctgt aaactaactg
    14941 gaatcgcctt gatgatactt ttacgaaact tggttacggt aataaaaata ttgaataatc
    15001 cacaaatgaa aaccattgcc aaggcttctt gccatgaaaa ccctaaagca aaaacaactg
    15061 tataagtgaa aaaagcgtta agtcccattc ctggtgccaa cgcataaggc acattggcaa
    15121 atagtcccat aattaaggtt gatatggctg ctgcgataat cgtagccaaa aagacagcat
    15181 tagagggcat ccccgctgca cctaaaatac ttgggttaac aaacaaaata taggacatgg
    15241 caaaaaaggt cgttaaacca gccataatct cagttgagac agttgtccca ttttcgctta
    15301 acttaaaaaa cttttccatt gaaatggagt ctccttaatt aaatagtagg taaaatcaaa
    15361 aagcgcttat cactagataa gtctttttga cacctcatta ttattgttat tgttcgtatt
    15421 aaaatgaaca ataacaatat gttaccattt ttt
//
LOCUS       DAUDWO010000044        15275 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.045, whole genome shotgun sequence.
ACCESSION   DAUDWO010000044 DAUDWO010000000
VERSION     DAUDWO010000044.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15275)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15275)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15275
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.045"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..510
                     /gene="enn"
                     /locus_tag="VHC05_001483"
     CDS             <1..510
                     /gene="enn"
                     /locus_tag="VHC05_001483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M-related protein Enn"
                     /protein_id="HEQ5402776.1"
                     /translation="RAAKKELEAKHQKLEADYQVSETSRKGLSRDLEASREANKKVTS
                     ELTQAKAQLSALEESKKLSEKEKAELQAKLDAQGKALKEQLAKQTEELAKLRAEKAAG
                     SKTPATKPANKERSGRAAQTATRPSQNKGMRSQLPSTGEAANPFFTAAAATVMVSAGM
                     LALKRKEEN"
     gene            846..4343
                     /gene="scpA/B"
                     /locus_tag="VHC05_001484"
     CDS             846..4343
                     /gene="scpA/B"
                     /locus_tag="VHC05_001484"
                     /EC_number="3.4.21.110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021340616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C5a peptidase ScpA/B"
                     /protein_id="HEQ5402777.1"
                     /translation="MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQA
                     VEAPQQTAVSEEAPSSSKETNPPQTPDDAEETVADKANDLAPQAPAKTADIPATSKET
                     IRDLNDPSHVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKSKARYQSKEDLEKA
                     KKDHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRIEG
                     AMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDET
                     KKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSP
                     DKQLTETATVKTADKQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALI
                     ERGDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDN
                     SKKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAK
                     LSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYF
                     SPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELY
                     YQATVQTDKVDGKHFALAPKALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMK
                     NGYFLEGFVRFKQDPKKEELMSIPYIGFRGDFGNLSTLEKPIYDSKDGSSYYHEANSD
                     AKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGT
                     FAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGN
                     VVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPIS
                     SGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPIYRERIAYTYMDE
                     DLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLE
                     GHSNKPEQDGSDQAPDKKPETKPEQDGSGQTPDKKPETKPEQDGSGQTPDKKPETKPE
                     KDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASTKDQLPTTNDKDTNRLHLLKLVM
                     TTFFLGLVAHIFKTKRTED"
     gene            4440..5621
                     /locus_tag="VHC05_001485"
     CDS             4440..5621
                     /locus_tag="VHC05_001485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285739.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="HEQ5402778.1"
                     /translation="MFRVENNKHSRYSIRKLSVGVTSIAIASLFLGKVAYAVDSIPPI
                     SLTQRTPATTSEKWHHIDDKGSIPLGISLEAAKKDFKEEVEKSRLSEEQKQTYNQKID
                     AETDKDELLSTYHRDYLTAVKNLPTSTEPVEASVQETQASVSDSMVTGDSTSVTADSP
                     KESPVAPASSPESEDSSVASSEETSSPETPVAPETPEEPAAPSPSPESEEPSVAASSE
                     ETPTPSTPEEPAAPSPSPESEEPSVAASSEETPTPSTPEEPAAPSPSPESEDSSVAAT
                     TSPSPSTPAESETQTPPAVTKDSDKPSSAAEKPAASSLVSEQTVQQPTSKRSSDKKEE
                     QEQSYSPNRSLSRQVMAHESGKYLPSTGEKAQPLFIATMTLMSLLGSLLVTKRQKETK
                     K"
     gene            5873..6793
                     /gene="lmb"
                     /locus_tag="VHC05_001486"
     CDS             5873..6793
                     /gene="lmb"
                     /locus_tag="VHC05_001486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003056036.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter substrate-binding
                     lipoprotein/laminin-binding adhesin Lmb"
                     /protein_id="HEQ5402779.1"
                     /translation="MKKGFFLMAMAVSLVMIAGCDKSANPKQPTQGMSVVTSFYPMYA
                     MTKEVSGDLNDVRMIQSGAGIHSFEPSVNDVAAIYDADLFVYHSHTLEAWARDLDPNL
                     KKSKVDVFEASKPLTLDRVKGLEDMEVTQGIDPATLYDPHTWTDPVLAGEEAVNIAKE
                     LGRLDPKHKDSYTKKAKAFKKEAEQLTEEYTQKFKKVRSKTFVTQHTAFSYLAKRFGL
                     KQLGISGISPEQEPSPRQLKEIQDFVKEYNVKTIFAEDNVNPKIAHAIAKSTGAKVKT
                     LSPLEAAPSGNKTYLENLRANLEVLYQQLK"
     gene            6806..9283
                     /locus_tag="VHC05_001487"
     CDS             6806..9283
                     /locus_tag="VHC05_001487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HEQ5402780.1"
                     /translation="MKKTYGYIGSVAAILLATHIGSYQLGKHHMGSATKDNQIAYIDD
                     SKGKAKAPKTNKTMDQISAEEGISAEQIVVKITDQGYVTSHGDHYHFYNGKVPYDAII
                     SEELLMTDPNYHFKQSDVINEILDGYVIKVNGNYYVYLKPGSKRKNIRTKQQIAEQVA
                     KGTKEAKEKGLAQVAHLSKEEVAAVNEAKRQGRYTTDDGYIFSPTDIIDDLGDAYLVP
                     HGNHYHYIPKKDLSPSELAAAQAYWSQKQGRGARPSDYRPTPAPGRRKAPIPDVTPNP
                     GQGHQPDNGGYHPAPPRPNDASQNKHQRDEFKGKTFKELLDQLHRLDLKYRHVEEDGL
                     IFEPTQVIKSNAFGYVVPHGDHYHIIPRSQLSPLEMELADRYLAGQTEDNDSGSDHSK
                     PSDKEVTHTFLGHRIKAYGKGLDGKPYDTSDAYVFSKESIHSVDKSGVTAKHGDHFHY
                     IGFGELEQYELDEVANWVKAKGQADELAAALDQEQGKEKPLFDTKKVSRKVTKDGKVG
                     YMMPKDGKNYFYARDQLDLTQIAFAEQELMLKDKKHYRYDIVDTGIEPRLAVDVSSLP
                     MHAGNATYDTGSSFVIPHIDHIHVVPYSWLTRDQIATIKYVMQHPEVRPDVWSKPGHE
                     ESGSVIPNVTPLDKRAGMPNWQIIHSAEEVQKALAEGRFATPDGYIFDPRDVLAKETF
                     VWKDGSFSIPRADGSSLRTINKSDLSQAEWQQAQELLAKKNAGDATDTDKPKEKQQAD
                     KSNENQQPSEASKEEEKEKESDNFIDSLPDYGLDRATLEDHINQLAQKANIDPKYLIF
                     QPEGVQFYNKNGELVTYDIKTLQQINP"
     gene            9453..9653
                     /locus_tag="VHC05_001488"
     CDS             9453..9653
                     /locus_tag="VHC05_001488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HEQ5402781.1"
                     /translation="MSEEKLKSKIEQASGGLKEGAGKLTGDKELEAKGFVEKTIAKGK
                     ELADDAKEAVEGAVDAVKEKLK"
     gene            complement(9724..10350)
                     /locus_tag="VHC05_001489"
     CDS             complement(9724..10350)
                     /locus_tag="VHC05_001489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402782.1"
                     /translation="MTLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTS
                     LSRVLAGFLQPKSGEVLVDGSHLPNKAFRPVQLIQQHPEQTMNPLWPMKKSLEEAYYP
                     SQDLRDAFGIQEKWLKRRPSELSGGELQRFSIVRSLHPETKYLIADEMTTMLDSITQA
                     SVWKSLLEIVKDRNLGLIIISHDFDMLEKLCDACYMIEENRTQLFKHT"
     gene            complement(10334..11137)
                     /locus_tag="VHC05_001490"
     CDS             complement(10334..11137)
                     /locus_tag="VHC05_001490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402783.1"
                     /translation="MTETLLSIKDLSITFTQYGRFLKPFQSTPIQALNLEVKKGELLA
                     IIGASGSGKSLLAHAIMDILPKNAAVTGDMIYRGQSLTSKRIKQLRGKEMTLIPQSVN
                     YLDPSMKVKHQVRLGISENAKATQEGLFHQFGLKESDGDLYPFQLSGGMLRRVLFTTC
                     ISDTVSLIIADEPTPGLHPDALQMVLDQLRSFADKGISVIFITHDIVAASQIADRITI
                     FKEGKAIETAPASFFSGGGEQLQTEFARRLWRTLPQQDFLKGVTHDLRG"
     gene            complement(11149..11970)
                     /locus_tag="VHC05_001491"
     CDS             complement(11149..11970)
                     /locus_tag="VHC05_001491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015631767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402784.1"
                     /translation="MILKRRTMVLWQLGIAISLILSILALNLYFYRTPLETNAALRNL
                     APSLNHLFGTDGLGRDMFVRTIKGLYFSLQVGLLGALMGVFLATVFGVLAGLGNSFID
                     KIIAWLVDLFIGMPHLIFMILISFVVGKGAQGVIIATAVTHWPSLARLIRNEVYDLKN
                     KAFVQLSKSMGKTPYYIVRHHILPLIASQIFIGFILLFPHVILHEASMTFLGFGLSAE
                     QPSVGIILSEAAKHISLGNWWLVIFPGLYLILVVNAFDTIGESLKKLFYPQTDHF"
     gene            complement(11967..12944)
                     /locus_tag="VHC05_001492"
     CDS             complement(11967..12944)
                     /locus_tag="VHC05_001492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402785.1"
                     /translation="MKRTTIIIIWKIIRCITLIFGVSVLTFVLLKQSPVDPVMASVNY
                     DTSLTPAQYKAIAHHYGLDKPALVQYFIWLKNVIQGHLGTSLVYRQPVSDIIRSRAGA
                     SFILMGLSWILSGLIGFILGTLSAFHQGKLLDRVVRWFSYLQISVPTFWIGLIFLLIF
                     SVQLGWFPIGISSPIGTLSQDITLADRIKHLMLPVFTLSILGIANVTLHTRTKMMSVL
                     SSEYVLFARARGETQWQIFKHHCLRNAIVPAITLHFSYFGELFGGSVLAEQVFSYPGL
                     GSTLTEAGLKSDTPLLLAIVMIGTLFVFAGNLIADILNSIINPQLRRKV"
     gene            complement(13057..14685)
                     /locus_tag="VHC05_001493"
     CDS             complement(13057..14685)
                     /locus_tag="VHC05_001493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017771899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEQ5402786.1"
                     /translation="MSKYLKYFSIITLFLTGLILVACQQQKPQTKERQRKQRPKDEIV
                     VSMGAKLPHEFDPKDRYGVHNEGNITHSTLLKRSPELDIKGELAKTYHLSEDGLTWSF
                     DLHDDFKFSNGEPVTADDVKFTYDMLKADGKAWDLTFIKNVEVVGKNQVNIHLTEAHS
                     TFTAQLTEIPIVPKKHYNDKYKSNPIGSGPYMVKEYKAGEQAIFVRNPYWHGKKPYFK
                     KWTWVLLDENTALAALESGDVDMIYATPELASKKVKGTRLLDIPSNDVRGLSLPYVKK
                     GVITDSPDGYPVGNDVTSDPAIRKALTIGLNRQKVLDTVLNGYGKPAYSIIDKTPFWN
                     PKTAIKDNKVAKAKQLLTKAGWKEQADGSRKKGDLDAAFDLYYPTNDQLRANLAVEVA
                     EQAKTLGITIKLKASNWDEMATKSHDSALLYAGGRHHAQQFYESHHPSLAGKGWTNIT
                     FYNNPTVTKYLDKAMTSSDLDKANEYWKLAQWDGKTGASTLGDLPNVWLVSLNHTYIG
                     DKRINVGKQGVHSHGHDWSLLTNIAEWTWDESTK"
     gene            14862..15086
                     /locus_tag="VHC05_001494"
     CDS             14862..15086
                     /locus_tag="VHC05_001494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402787.1"
                     /translation="MTYFRLKKELNWSLRSKGIVVYEGNQKLQIAINTGKNNSEKVFF
                     DTFLEVVRAAATFSTAKSICFGLGLLRSQK"
BASE COUNT         5157 a         3061 c         3009 g         4048 t
ORIGIN      
        1 cgagcagcta aaaaagaact agaagctaag caccaaaaat tagaggctga ttaccaagtt
       61 tcagagacta gccgtaaggg tctaagccgt gaccttgaag catcacgtga agctaataag
      121 aaggttacat ctgagttaac acaagcaaaa gctcaactct cagcgcttga agaaagtaag
      181 aaattatcag aaaaagaaaa agctgagtta caagcaaaac tagatgcaca aggaaaagcc
      241 ctcaaagaac aattagcaaa acaaactgaa gagcttgcaa aactaagagc tgaaaaagca
      301 gcaggttcaa aaacacctgc taccaaacca gctaataaag aaagatcagg tagagctgct
      361 caaacagcta caagacctag ccaaaataaa ggaatgaggt cacaattacc gtcaacaggc
      421 gaagcagcca acccattctt tacagcagca gctgcaacag tgatggtatc tgcaggtatg
      481 cttgctctaa aacgcaaaga agaaaactaa gcctttagaa cttgattttt gtaacggtgc
      541 aatagacaaa agcaagcaag gccaaaaact gagaaagtcc taaaaagctg gcctttaccc
      601 ctcaaaatta atgttttata ataaagatgt tagtaatata attgataaat gagatacatt
      661 taatcattat ggcaaaagca agaaaaatag ctgtatcata tgcaaataac ccctgtttgc
      721 tctttaaaaa aagacgttat ccttatttct ctacgcacag atggacagct aggagagaat
      781 cgtttgattc tctcttttct taatggtcat aaagacaaag tctctcatca ggaaaggacg
      841 acacattgcg taaaaaacaa aaactaccat ttgataaact tgccattgcg ctcatgtcta
      901 cgagcatctt gctcaatgca caatcagaca ttaaagcaaa tactgtgaca gaagacactc
      961 ctgctaccga gcaagccgta gaagccccac aacaaacagc ggtttctgag gaagcaccat
     1021 catcatcaaa ggaaactaac cccccacaaa ctcctgatga cgcagaagaa acagtagcag
     1081 ataaggctaa tgatctagcc cctcaagctc ctgctaaaac tgctgatata ccagcaacct
     1141 caaaagagac tattagggat ttgaacgacc cttctcatgt caaaaccctg caggaaaaag
     1201 caggcaaggg agctgggact gttgttgcag tgattgatgc tggttttgat aaaaatcatg
     1261 aagcgtggcg cttaacagac aaatctaaag cacgttacca atcaaaagaa gatcttgaaa
     1321 aagccaaaaa agatcacggt attacctatg gtgagtgggt caatgataag gttgcttatt
     1381 accacgacta tagtaaagat ggtaaaaccg ctgtcgatca agagcacggc acacacgtgt
     1441 cagggatctt gtcaggaaat gctccatctg aaacgaaaga accttaccgc atagaaggtg
     1501 cgatgcctga ggctcaattg cttttgatgc gtgtcgaaat tgtaaatgga ctagcagact
     1561 atgctcgtaa ctacgctcaa gctatcagag atgctgtcaa cttgggagct aaggtgatta
     1621 atatgagctt tggtaatgct gcactagctt acgccaacct tccagacgaa actaaaaaag
     1681 cctttgatta tgccaaatca aaaggtgtta gcattgtgac ctcagctggt aatgatagta
     1741 gctttggggg caagacccgt ctacctctag cagatcatcc tgattatggg gtggttggga
     1801 cacctgcagc ggcagactca acattgacag ttgcttctta cagcccagat aaacagctca
     1861 ctgaaactgc tacggtcaaa acagccgata agcaagataa agaaatgcct gttctttcaa
     1921 caaaccgttt tgagccaaac aaggcttacg actatgctta tgctaatcgt gggatgaaag
     1981 aagatgattt taaggatgtc aaaggtaaga ttgcccttat tgaacgtggc gatattgatt
     2041 tcaaagataa gattgcaaac gctaaaaaag ctggtgctgt aggagtcttg atctatgaca
     2101 atcaggacaa gggcttcccg attgaattgc cgaatgttga ccagatgcct gcggccttta
     2161 tcagtcgaaa agacggtctc ttattaaaag acaattctaa aaaaaccatc accttcaatg
     2221 cgacacctaa ggtattgcca acagcaagtg gcaccaaact aagccgcttc tcaagctggg
     2281 gtctgacagc tgacggcaat attaagccag atattgcagc acccggccaa gatattttgt
     2341 catcagtggc taacaacaag tatgccaaac tttctggaac tagtatgtct gcgccattgg
     2401 tagcgggtat catgggactg ttgcaaaagc aatatgagac acagtatcct gatatgacac
     2461 catcagagcg tcttgattta gctaaaaaag tattgatgag ctcagcaact gccttatatg
     2521 atgaagatga aaaagcttat ttttctcctc gccaacaagg agcaggagca gtcgatgcta
     2581 aaaaagcttc agcagcaacg atgtatgtga cagataagga caatacctca agcaaggttc
     2641 acctgaacaa tgtttctgat aaatttgaag taacagtaac agttcacaac aaatctgata
     2701 aacctcaaga gttgtattac caagcaactg ttcaaacaga taaagtagat ggaaaacact
     2761 ttgccttggc tcctaaagca ttgtatgaga catcatggca aaaaatcaca attccagcca
     2821 atagcagcaa acaagtcacc gttccaatcg atgctagtcg atttagcaag gacttgcttg
     2881 cccaaatgaa aaatggctat ttcttagaag gttttgttcg tttcaaacaa gatcctaaaa
     2941 aagaagagct tatgagcatt ccatatattg gtttccgagg tgattttggc aatctgtcaa
     3001 ccttagaaaa accaatctat gatagcaaag acggtagcag ctactatcat gaagcaaata
     3061 gtgatgccaa agaccaatta gatggtgacg gattacagtt ttacgctctg aaaaataact
     3121 ttacagcact taccacagag tctaacccat ggacgattat taaagctgtc aaagaagggg
     3181 ttgaaaacat agaggatatc gaatcttcag agatcacaga aaccattttt gcaggtactt
     3241 ttgcaaaaca agacgatgat agtcactact atatccaccg tcacgctaat ggcaagccat
     3301 atgctgcgat ctctccaaat ggggacggta acagagatta tgtccaattc caaggtactt
     3361 tcttgcgtaa tgctaaaaac cttgtggctg aagtcttgga caaagaagga aatgttgttt
     3421 ggacaagtga ggtaaccgag caagttgtta aaaactacaa caatgacttg gcaagcacac
     3481 ttggttcaac ccgttttgaa aaaacgcgtt gggacggtaa agataaagac ggcaaagttg
     3541 ttgctaacgg aacatacacc tatcgtgttc gctacactcc gattagctca ggtgcaaaag
     3601 aacaacacac tgattttgat gtgattgtag acaatacgac acctgaagtc gcaacatcgg
     3661 caacattctc aacagaagat cgtcgtttga cacttgcatc taaaccaaaa accagccaac
     3721 cgatttaccg tgagcgtatt gcttacactt atatggatga ggatctgcca acaacagagt
     3781 atatttctcc aaatgaagat ggtaccttta ctcttcctga agaggctgaa acaatggaag
     3841 gtgctactgt tccgttgaaa atgtcagact ttacttatgt tgttgaagat atggctggta
     3901 acatcactta tacaccagtg actaagctat tggagggcca ctctaataag ccagaacaag
     3961 acggttcaga tcaagcacca gacaaaaaac cagaaactaa accagaacaa gacggttcag
     4021 gtcaaacacc agacaaaaaa ccagaaacta aaccagaaca agacggttca ggtcaaacac
     4081 cagataaaaa accagaaact aaaccagaaa aagatagttc aggtcaaaca ccaggtaaaa
     4141 ctcctcaaaa aggtcaacct tctcgtactc tagagaaacg atcttctaag cgtgctttag
     4201 ctacaaaagc atcaacaaaa gatcagttac caacgactaa tgacaaggat acaaatcgtt
     4261 tacatctcct taagttagtt atgaccactt tcttcttggg attagtagct catatcttta
     4321 aaacaaaacg cactgaagat tagtacaact gatcagatgg ctactattga tgatgagtta
     4381 gatcagtctt cttttcaaaa gaaggcatag cagtataaaa atagatatgt taggacaata
     4441 tgtttagagt agaaaataac aaacacagcc gctattccat tcgcaaactg agcgttgggg
     4501 taacgagtat agcaattgcg agtctctttt taggaaaggt tgcctatgcc gtagatagca
     4561 tccctccaat ctctcttact caaaggactc cagccactac atcagaaaaa tggcatcata
     4621 ttgatgataa gggctctatt cctttaggta taagcttaga agctgccaaa aaagatttta
     4681 aagaagaagt agaaaaatca cgtttgtctg aagaacaaaa acaaacgtat aatcaaaaaa
     4741 ttgatgctga aacagacaaa gacgaactat tgtcaacgta tcatagagac tatctgacag
     4801 ccgttaagaa tcttccaacg tctactgagc cagttgaggc atccgtgcag gagacacagg
     4861 catcagtttc agattcgatg gtgacaggtg attcaacatc agttacggct gattctccta
     4921 aggaaagtcc agtagcccca gcttcatcac ctgagagtga ggattcttca gtagcatctt
     4981 ctgaggaaac ctcatctcca gaaactccag tggccccaga aactcctgaa gagccagcag
     5041 ctccatctcc atcacctgag agtgaagaac cttcagtagc agcttcttct gaggaaaccc
     5101 caactccatc aactccagaa gaaccagcag ctccatctcc atcacctgag agtgaggaac
     5161 cttcagtagc agcttcttct gaggaaaccc caactccatc aactccagaa gagccagcag
     5221 ctccatctcc atctcctgag agtgaggatt cttcagtagc agctacgaca agcccgtctc
     5281 catcaactcc agctgaatca gagactcaga cgccaccagc tgttactaaa gactctgata
     5341 agccatcttc agcagctgaa aaaccagcag cctcttcact tgtttcagaa caaaccgttc
     5401 aacaaccaac ttcaaagaga tcttctgata aaaaagaaga gcaagaacag tcttactctc
     5461 caaatcgctc attgtcaaga caggttatgg cccatgagtc aggtaagtac ttgccttcaa
     5521 caggtgaaaa agcacagcca ctctttatag ctactatgac tttgatgtct ctacttggca
     5581 gtcttttagt cacaaaacgc caaaaagaaa ctaaaaaata gtattactta aactgataag
     5641 agcttattta atagagagaa ccaatttggt tctctctatt tttttatatg tgctgcctca
     5701 tcaaaaagaa gttaggacaa atagctgtca acaattacct tttgcttatc ccttcagttg
     5761 ctgtgatttt atcatacagt gataaaagat ggtagttgcc attgacaaag cattgataaa
     5821 ggagtaaaat taactggtta ataactggtt aaattataat tgaggaggta ctatgaaaaa
     5881 aggttttttt ctcatggcta tggctgtgag tttagtaatg atagcagggt gtgataagtc
     5941 agcaaacccc aaacagccta cgcaaggcat gtcagttgta accagctttt acccaatgta
     6001 tgcgatgaca aaagaagtat ctggagacct caatgatgtg aggatgatcc aatcaggtgc
     6061 aggcattcat tcctttgaac cgtctgtaaa tgatgtggca gctatttatg acgcggattt
     6121 gtttgtttac cattcacata ctttagaagc ttgggcaagg gatctagacc ctaatttaaa
     6181 aaaatcaaag gttgatgtgt ttgaagcgtc aaaacctctg acactagata gagtcaaagg
     6241 gctagaagat atggaagtca cacaaggcat tgaccctgcg acactttatg acccacatac
     6301 ctggacagat cccgttttag ctggtgagga agctgttaat atcgctaaag agctaggacg
     6361 tttggatcct aaacacaaag acagttacac taaaaaggct aaggctttca aaaaagaagc
     6421 agagcaacta actgaagaat acactcaaaa atttaaaaag gtgcgctcaa aaacattcgt
     6481 gacgcagcac acggcatttt cttatctggc taaacgattc ggcttgaaac aacttggtat
     6541 ctcgggtatt tctccagagc aagagccctc tcctcgccaa ttgaaagaaa ttcaagactt
     6601 tgtcaaagaa tacaacgtca aaactatttt tgcagaagac aatgtcaatc ccaaaattgc
     6661 tcatgctatt gcgaaatcaa caggagctaa agtaaagaca ttaagtccac ttgaagctgc
     6721 tccaagcgga aacaagacat atctagaaaa tcttagagca aatttggaag tgctctatca
     6781 acagttgaag taaaggagat tattagtgaa gaaaacatat ggttatatcg gctcagttgc
     6841 tgccatttta ctagctactc atattggaag ttaccaactt ggtaagcatc atatgggttc
     6901 agcaacaaag gacaatcaaa ttgcctatat tgatgatagc aaaggtaagg caaaagcccc
     6961 taaaacaaac aaaacgatgg atcaaatcag tgctgaagaa ggcatctctg ctgaacagat
     7021 cgtggtcaaa attactgacc aaggctatgt gacctcacac ggtgaccatt atcattttta
     7081 caatgggaaa gttccttatg atgcgattat tagtgaagag ttgttgatga cggatcctaa
     7141 ttaccatttt aaacaatcag acgttatcaa tgaaatctta gacggttacg ttattaaagt
     7201 caatggcaac tattatgttt acctcaagcc aggtagcaag cgcaaaaaca ttcgaaccaa
     7261 acaacaaatt gctgagcaag tagccaaagg aactaaagaa gctaaagaaa aaggtttagc
     7321 tcaagtggcc catctcagta aagaagaagt tgcggcagtc aatgaagcaa aaagacaagg
     7381 acgctatact acagacgatg gctatatttt tagtccgaca gatatcattg atgatttagg
     7441 agatgcttat ttagtacctc atggtaatca ctatcattat attcctaaaa aagatttgtc
     7501 tccaagtgag ctagctgctg cacaagctta ctggagtcaa aaacaaggtc gaggtgctag
     7561 accgtctgat taccgcccga caccagcccc aggtcgtagg aaagccccaa ttcctgatgt
     7621 gacgcctaac cctggacaag gtcatcagcc agataacggt ggctatcatc cagcgcctcc
     7681 taggccaaat gatgcgtcac aaaacaaaca ccaaagagat gagtttaaag gaaaaacctt
     7741 taaggaactt ttagatcaac tacaccgtct tgatttgaaa taccgtcatg tggaagaaga
     7801 tgggttgatt tttgaaccga ctcaagtgat caaatcaaac gcttttgggt atgtggtgcc
     7861 tcatggagat cattatcata ttatcccaag aagtcagtta tcacctcttg aaatggaatt
     7921 agcagatcga tacttagccg gccaaactga ggacaatgac tcaggttcag atcactcaaa
     7981 accatcagat aaagaagtga cacatacctt tcttggtcat cgcatcaaag cttacggaaa
     8041 aggcttagat ggtaaaccat atgatacgag tgatgcttat gtttttagta aagaatccat
     8101 tcattcagtg gataaatcag gagttacagc taaacacgga gatcatttcc actatatagg
     8161 atttggagaa cttgaacaat atgagttgga tgaggtcgct aactgggtga aagcaaaagg
     8221 tcaagctgat gagcttgctg ctgctttgga tcaggaacaa ggcaaagaaa aaccactctt
     8281 tgacactaaa aaagtgagtc gcaaagtaac aaaagatggt aaagtgggct atatgatgcc
     8341 aaaagatggc aagaactatt tctatgctcg tgatcaactt gatttgactc agattgcctt
     8401 tgccgaacaa gaactaatgc ttaaagataa gaagcattac cgttatgaca ttgttgacac
     8461 aggtattgag ccacgacttg ctgtagatgt gtcaagtctg ccgatgcatg ctggtaatgc
     8521 tacttacgat actggaagtt cgtttgttat cccacatatt gatcatatcc atgtcgttcc
     8581 gtattcatgg ttgacgcgcg atcagattgc aacaatcaag tatgtgatgc aacaccccga
     8641 agttcgtccg gatgtatggt ctaagccagg gcatgaagag tcaggttcgg tcattccaaa
     8701 tgttacgcct cttgataaac gtgctggtat gccaaactgg caaattatcc actctgctga
     8761 agaagttcaa aaagccctag cagaaggtcg ttttgcaaca ccagacggct atattttcga
     8821 tccacgagat gttttggcca aagaaacttt tgtatggaaa gatggctcct ttagcatccc
     8881 aagagcagat ggcagttcat tgagaaccat taataaatct gatctatccc aagctgagtg
     8941 gcaacaagct caagagttat tggcaaagaa aaacgctggt gatgctactg atacggataa
     9001 acccaaagaa aagcaacagg cagataagag caatgaaaac caacagccaa gtgaagccag
     9061 taaagaagaa gaaaaagaaa aagaatcaga taactttata gacagtttac cagactatgg
     9121 tctagataga gcaaccctag aagatcatat caatcaatta gcacaaaaag ctaatattga
     9181 tcctaagtat ctcattttcc aacccgaagg tgtccaattt tataataaaa atggtgaatt
     9241 ggtaacttat gatatcaaga cacttcaaca aataaaccct taaccaaaag aagatctcat
     9301 tgttaaagca ctgctttgtc aaagtaagtt acggtgattt tgaagtcatt ctatgtaacg
     9361 agtagtgata aaagttggat aatagtggtt ttcttttgca aagaaatggt atccatgtta
     9421 gaataataaa aaaaaagagg aggattctaa tcatgtcaga agaaaaatta aaatcaaaaa
     9481 ttgagcaagc atctggtggc ctaaaagaag gtgctggtaa gttgacaggt gataaagagc
     9541 tagaagcaaa aggatttgtt gaaaaaacaa ttgctaaagg caaagaactt gcagacgatg
     9601 caaaagaagc ggttgaaggt gctgtagatg ccgttaagga aaaattaaaa taattaaaaa
     9661 accagctgta agctggtttt tttaatggtg tgattttgtt agaaaaagac tcaataggta
     9721 atgttaggta tgcttgaaca gttgagtacg attctcttca atcatatagc acgcgtcaca
     9781 aagtttttct aacatatcaa aatcatgact aataatgatg agacctaaat ttctatcctt
     9841 tacaatctcc aacaggcttt tccatacact agcttgtgta atgctatcca acatagtagt
     9901 catttcatct gcaataaggt atttcgtctc tggatgtaat gaacgcacaa tcgaaaagcg
     9961 ttgcaattcc cctcccgaga gttcactagg acgacgcttt agccattttt cttgaatgcc
    10021 aaaagcatct cgcaaatctt gacttggata gtaggcttct tccaaacttt ttttcatagg
    10081 ccataaagga ttcatggttt gttcaggatg ttgttggata agttgtacag gtctaaatgc
    10141 tttgttaggc aaatgactgc catcaactaa tacttcacca gatttaggct gcaaaaaacc
    10201 ggcaagcact ctggataaac tcgtttttcc acacccactt tgtccaaata tccctaagat
    10261 ttgaccaggt gctacctcta aatcaatctc cttaaaaagc cattgatctt ttttatgata
    10321 aaagccaagc tttttagcct ctaaggtcat gagtaactcc tttcaaaaag tcttgctgag
    10381 ggagtgtgcg ccataaacgt ctcgcaaatt ccgtttgtaa ttgctctcca cctccgctaa
    10441 aaaagctagc tggggctgtt tcaatagctt ttccctcttt aaaaatagtt atacgatccg
    10501 caatttgact agctgctaca atatcatgag tgataaagat gacgcttatt cctttatctg
    10561 caaaagagcg tagttgatct aaaaccattt gcagagcatc tggatgtaat ccaggggtgg
    10621 gctcatccgc aataatcaaa gaaaccgtat cactaataca cgttgtaaac aaaacacgtc
    10681 ggagcattcc gccagaaagt tggaaaggat acaagtcacc atcactttct tttaaaccaa
    10741 actgatgaaa taatccttct tgagtagcct tagcattttc tgagataccc aagcgcacct
    10801 gatgcttgac tttcatagat ggatctaaat aattaacgga ttgtggaatc aacgtcattt
    10861 cttttcctcg caactgttta atgcgtttag aagttagtga ttgaccacga taaatcatat
    10921 ctcctgttac agctgcattt ttaggaagaa tatccataat agcatgtgct aataaactct
    10981 tgcctgaacc actagcacct ataatagcta ataactcacc ttttttaact tctaaattca
    11041 gcgcttggat cggtgtggat tgaaatggtt ttaaaaatct tccgtattga gtgaaggtga
    11101 tggagaggtc tttaatgctt aataatgttt ctgtcatatc tctacctcct aaaaatgatc
    11161 cgtttgaggg taaaagagtt tctttaaaga ttctccgata gtatcaaagg cattgacaac
    11221 caaaataaga taaaggcctg gaaaaatcac caaccaccaa ttgccaagag agatatgctt
    11281 agctgcctct gacaaaatga taccaaccga aggttgttcg gcagaaaggc caaatcctaa
    11341 gaaagtcatg gatgcttcat gcaagatgac gtgcggaaat aagaggataa acccaatgaa
    11401 aatttgagaa gcaatcaaag gcaggatatg atgcctcaca atataataag gcgtttttcc
    11461 catgctttta gagagctgga caaaggcttt attctttaga tcatagactt cattgcggat
    11521 aagccttgct agagagggcc aatgggtaac agctgttgca atgataaccc cttgagcccc
    11581 tttcccaaca acaaaagaaa tgagaatcat aaaaatcaaa tgaggcatac caataaacaa
    11641 atcaaccaac caggctatta ttttatcaat aaagctattt cctagacctg caagcactcc
    11701 aaaaacggtc gcaagaaaga ctcccataag ggcacctaat aagccgactt gtaaagagaa
    11761 ataaagccct ttaatcgttc tgacaaacat atccctacct aaaccatctg ttccaaaaag
    11821 atggtttaat gaaggagcga ggttgcgtaa agctgcattg gtttccaaag gcgtcctata
    11881 gaaataaaga tttaaggcta gaatactaag aatgagagaa atggcgatac ctagttgcca
    11941 taaaaccatc gttcgacgtt tcaatatcat acttttctcc ttaactgtgg attgatgatg
    12001 ctatttaaaa tgtccgcaat aagattgccc gcaaaaacaa ataatgttcc tatcatcacg
    12061 atagctagaa gtagcggtgt atcactttta agtcctgctt cagtgagggt agaccctaag
    12121 ccaggatatg agaaaacttg ctcagcaaga acagatcctc caaacaattc tccaaaatag
    12181 gaaaaatgca gtgtaatagc tggtacgata gcatttctaa ggcaatgatg tttaaaaatt
    12241 tgccactgtg tttccccacg cgctctggca aataagacat attcactaga aagcaccgac
    12301 atcattttag ttctcgtatg aagagtgaca ttggcaatgc ctagaatact tagcgtgaaa
    12361 acaggtaaca taaggtgctt aatccgatca gctaacgtaa tatcttgact caaagtgcct
    12421 atcggggaag aaataccaat cgggaaccac cccagctgga cagaaaagat taataaaaaa
    12481 atgaggccaa tccaaaacgt tggtactgat atctgaaggt aagaaaacca cctgacaact
    12541 cggtcaagta atttcccttg atggaaagct gataacgttc ctaagataaa tccaataaga
    12601 cccgataaga tccaagagag tcccataagt atgaaagaag cacctgcccg tgatctaata
    12661 atatcactaa caggttgccg ataaacgagc gaggtcccta aatgtccctg tatcacattt
    12721 ttcaaccaaa taaaatattg gactagagct ggcttatcca agccatagtg gtgagcaatc
    12781 gctttgtact gagcaggggt tagtgatgtg tcataattga cacttgccat gacgggatct
    12841 actggagatt gttttaacaa aacgaaggtc aaaacagata ccccaaaaat aagtgtgata
    12901 catctgatga ttttccagat gataataatg gtagtacgtt tcacaatgaa atctccttaa
    12961 tcgataagaa aaggagccga ggaaacgatc agcacagttt tgtgtatctt gttttctcag
    13021 actccaaact taaagtcgct gtattaacta aacgcgttac ttagttgatt catcccaagt
    13081 ccactcggca atgttagtca ataatgacca atcatgacca tgactgtgga cgccttgttt
    13141 acctacattg atacgtttat caccaatata agtatggtta aggctcacca accatacatt
    13201 tggcaaatct ccaagagtag aagcacctgt tttgccatcc cactgcgcta acttccaata
    13261 ttcgttagct ttgtcaaggt cagaagatgt cattgctttg tcaaggtact tagtcacggt
    13321 aggattgtta taaaacgtaa tattggtcca acctttacct gctaggcttg gatgatgtga
    13381 ttcataaaat tgctgcgcgt gatgacgtcc tccggcataa agtaaggctg agtcatgtga
    13441 cttcgttgcc atttcatccc agttactagc tttgagttta atagtaatcc ctagggtttt
    13501 ggcttgctct gctacttcaa cggctaagtt cgctcgcaat tgatcattag tagggtagta
    13561 cagatcaaac gctgcatcaa ggtcaccttt tttacggcta ccgtctgctt gttctttcca
    13621 tcccgctttt gtcaacaatt gcttagcttt agctacttta ttatctttaa tggctgtttt
    13681 tggattccaa aatggtgttt tatcaataat tgaataagct ggtttaccat aaccatttaa
    13741 aaccgtatcg agaacttttt gtctatttaa accaatagtc aaggctttgc ggattgctgg
    13801 atcactagtg acatcatttc ctacaggata accatcagga gaatcagtga tgacgccttt
    13861 tttcacataa ggtaatgata agccgcgcac atcatttgat ggaatgtcaa ggaggcgagt
    13921 gcctttgact ttcttactag caagttctgg tgtcgcgtag atcatatcaa catcaccaga
    13981 ttctaaagca gctagtgctg tgttttcatc aagtaagacc caagtccact ttttaaagta
    14041 tggttttttc ccatgccaat aagggttacg aacaaaaata gcttgttctc cagccttata
    14101 ttcttttacc atgtaaggtc ctgaaccgat aggattgctc ttatacttat cattgtaatg
    14161 ttttttaggg acgattggga tttcagtcaa ctgtgctgta aatgtcgaat gcgcctcagt
    14221 caaatggata ttgacctgat ttttcccaac tacttcaacg ttcttgatga aggttagatc
    14281 ccaagctttt ccatctgctt tcaacatatc ataagtaaac ttaacatcat cagcagtaac
    14341 aggctcacca tttgagaatt taaaatcatc atgcaaatca aacgaccaag tcagcccatc
    14401 ttcagagaga tggtatgttt tagcaagctc tccttttata tctagttcag gagaacgttt
    14461 caatagagtg ctatgagtga tattcccttc attgtggact ccataacggt cctttggatc
    14521 gaattcatga gggagctttg cccccataga aacgacaatt tcgtcttttg gacgttgttt
    14581 gcgctgacgt tcttttgttt gaggcttttg ttgttgacat gcaactaaaa taagcccagt
    14641 caaaaataac gtgataatag agaagtattt taggtatttt gacacaatca aatctcctta
    14701 tttctaataa taaataataa tagtaacgac tccatctcat tatagcaata aacaaatagg
    14761 agggcaattg tttaactggt taattagaat ttttgttatt ttcaggaaga tactcaggtt
    14821 ttttaataag ttgatgtatt aacaaaagat aaagaggttt catgacttat tttagattaa
    14881 aaaaagaatt aaactggtca ctaagaagta aaggaattgt agtttacgaa gggaatcaaa
    14941 aacttcagat agccattaat acaggtaaaa ataacagtga aaaagtcttt tttgatactt
    15001 ttcttgaggt ggttcgggcg gcagcgactt tctccacagc aaaaagcatc tgttttggtc
    15061 ttggcttact tcgttcgcag aaataggaaa tcgggtatca cattagcagg gtagttcatg
    15121 ctttttgagc atcaaactgg gtttgtctac gttctaaaag ctttcttcat ttttgtatca
    15181 taccccccta caagtagaaa aagcataata aagaaaattt ataaacaaaa atggctagta
    15241 ttatcaagga atttatcaat ttttgttttt taaaa
//
LOCUS       DAUDWO010000045        13874 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.046, whole genome shotgun sequence.
ACCESSION   DAUDWO010000045 DAUDWO010000000
VERSION     DAUDWO010000045.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13874)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13874)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13874
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.046"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            12..200
                     /locus_tag="VHC05_001495"
     CDS             12..200
                     /locus_tag="VHC05_001495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Paratox"
                     /protein_id="HEQ5402788.1"
                     /translation="MLTYDEFKQAIDREYITGDTVMIVRKNGQIFDYVLPHEEVRNGE
                     VVTIERISDVMAELSESE"
     gene            608..1084
                     /locus_tag="VHC05_001496"
     CDS             608..1084
                     /locus_tag="VHC05_001496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HEQ5402789.1"
                     /translation="MTQLATICYIDNGDSLLLLHRNKKENDVHKGKWISVGGKLEAGE
                     TPDECARREILEETHLTVTEMAFKGIITFPEFTPGHDWYTYVFKVTGFEGDLISDEES
                     REGTLEWVPYDQVLEKPTWEGDYDIFKWILEDRPFFSAKFTYDQNNQLMDKSVTFY"
     gene            1142..2323
                     /locus_tag="VHC05_001497"
     CDS             1142..2323
                     /locus_tag="VHC05_001497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HEQ5402790.1"
                     /translation="MSLIPEKSRTDSLFYKWFLNNQATMALVITLLAFLTIFVFTKIS
                     FLFMPVISFFAVIMLPLVISTILYYLTKPLVDLINHLGPNRTTSIFIVFGLITLLFVW
                     AISGFVPMVQTQLTSFIEDLPKYVGKVNEEANKLLENEWLVSYKPQLQDMLTHTSQKA
                     LDYAQSFSKNAIDWAGNFAGAIARITVAIIISPFILFYFLRDSSHMKNGLVNVLPLKL
                     RVPMVRVLGDINKQLSGYVQGQVTVAIVVGFMFSIMFSLVGLKYAITFGIIAGFLNMI
                     PYLGSFLAMIPVVIMAMVQGPFMLVKVLVIFMIEQTIEGRFVAPLVLGNKLSIHPITI
                     MFLLLTAGSMFGVWGVFLVIPIYASVKVVIKELFDWYKKVSGLYDEEVLVIEEVKDHV
                     K"
     gene            2313..3560
                     /locus_tag="VHC05_001498"
     CDS             2313..3560
                     /locus_tag="VHC05_001498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003043897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HEQ5402791.1"
                     /translation="MLNSEKMIASLDQQDLAHAEKYFQKALKEDDADSLIALGEYLES
                     IGFLPHAKRIYLQLADDYPELNINLAQIAAEDDAIEEAFLYLDKVSKDSPNYLSALLV
                     MADLYDLEGLTEVAREKLLQAVAISSEPLVIFGLAEIDMSLQYFKEAIDYYAQLDNRQ
                     ILELTGISTYQRIGRAYASLGKFEAAIEFLEKAVAIEYEDETVFELATLMYDQENYQK
                     ANLYFKQLETINPDYPGYEYGYALSLHEEHKTSEALRLVQQGLRKNAFDSQLLLLASQ
                     LSYELHDRQNAENYLLQAKEVAVDDEEILMRLVTLYFDAERFEEVIALNRETIDNVLT
                     KWTIAKAYHALEQEEVALALYNEISADLAENPEFLQDYAYLLREFGQFHKAIQMATAY
                     LRQVPDDVNMQDFLDHIKHQQSE"
     gene            complement(3619..5271)
                     /gene="fbp54"
                     /locus_tag="VHC05_001499"
     CDS             complement(3619..5271)
                     /gene="fbp54"
                     /locus_tag="VHC05_001499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rqc2 family fibronectin-binding protein Fbp54"
                     /protein_id="HEQ5402792.1"
                     /translation="MSFDGFFLHHLTNELKENLLYGRIQKVNQPFERELVLTIRNHRK
                     NYKLLLSAHPVFGRLQITQADFQNPQVPNTFTMIMRKYLQGAVIEQLEQIDNDRIIEI
                     KVSNKNEIGDAIQATLIIEIMGKHSNIILVDRAENKIIESIKHVGFSQNSYRTILPGS
                     TYIEPPKTAAVNPFTITDVPLFEILQTQELTVKRLQQHFQGLGRDTAKELAELLTTDK
                     LKRFREFFARPTQANLTTASFAPVLFSDSHATFETLSDMLDHFYQDKAERDRINQQAS
                     DLIHRVQTELDKNRNKLSKQEAELLATKNAELFRQKGELLTTYLSLVPNNQDSVILDN
                     YYTGEKIEIALDKALTPNQNAQRYFKKYQKLKEAVKHLSGLIADTKQSITYFESVDYN
                     LSQASIDDIEDIREELYQAGFLKSRQRDKRHKRKKPEQYLASDGKTILMVGRNNLQNE
                     ELTFKMAKKGELWFHAKDIPGSHVIIKDNLDPSDEVKTDAAELAAYYSKARLSNLVQV
                     DMIEAKKLHKPSGAKPGFVTYTGQKTLRVTPDQAKILSMKLF"
     gene            5625..6623
                     /locus_tag="VHC05_001500"
     CDS             5625..6623
                     /locus_tag="VHC05_001500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEQ5402793.1"
                     /translation="MKNKSLIATLLVLTVIVIGSLLSKGVSKENRDLANQQNITIGIL
                     QLVTHEALDDIKRGIEDQLKKQKPQKQNVVIKVMNAEGDQSKIQTMSRQLVQSGSDIV
                     IGIATPAAQGLAAASKDIPVVMSAVSDPVGSRLVMQLDQPEANVTGLSNKVPVKQTID
                     LMKKLTPHVKTVGILYASNEDNSLSQVKEFRRLARKKGYQVISYAVPSTNEVPATMSV
                     MLGKVDAVFIPQDNTIASAFSSVMTTSKAAKIPVYTSVDRMVEKGGLAAISQNQYDLG
                     VQTANQVLKLIKGKRVVDVPVKVVDIGQPLINKNVAAELGIAINREDFPSASFIEN"
     gene            6969..7838
                     /locus_tag="VHC05_001501"
     CDS             6969..7838
                     /locus_tag="VHC05_001501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003064298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402794.1"
                     /translation="MIISSVSQGLIWGVLGLGIYLTFRILNFPDMTTEGSFPLGGAVA
                     VTAISLGWNPFLSTLLGMLSGALAGFLTGLLYTKGKMPTLLAGILVMTSCNSIMLMVM
                     GRANLGLHDHKRIQDCFPFSIDLNSLLTGLITVVIVISVLIYFLYTNLGQAYIATGDN
                     KDMAKSFGINTDWMEVMGLVVSNSLIALSGALVSQQDGYADVSKGIGVIVIGLASIIV
                     GEVLYSTGLTLLERLIAIVIGSILYQFLISVVITLGFNTSYLKLISALVLALCLMIPV
                     VKERFFKGVRLTR"
     gene            7835..8593
                     /locus_tag="VHC05_001502"
     CDS             7835..8593
                     /locus_tag="VHC05_001502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402795.1"
                     /translation="MTKIIELINATVDVDNGFEDAKTILDNVTLTIYEHDFLTILGGN
                     GAGKSTLFNVIAGTLSLTRGQIRILGQDVTHWPAEKRALYLSRVFQDPKMGTAPRMTV
                     AENLLIARQRGEKRSLASRKITEHLASFEDLVKRTGNGLEKHLETPAGLLSGGQRQAL
                     SLLMATLKKPALLLLDEHTAALDPKTSQSLMQLTDEFVTKDGLTALMITHHMEDALTY
                     GNRLIVMKDGNIIKDLNQMEKEQMTITDYYQLFD"
     gene            8797..10458
                     /locus_tag="VHC05_001503"
     CDS             8797..10458
                     /locus_tag="VHC05_001503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HEQ5402796.1"
                     /translation="MTDIKMIALGGVREYGKNFYLVEINDSMFILDAGLKYPENEQLG
                     VDLVIPNLDYVIENKGKVQGIFLSHGHADAIGALPYLLAEVSAPVFGSELTIELAKLF
                     VKSNNSTKKFNNFHVVDSDTEIEFKDGLVSFFRTTHSIPESMGIVIGTDKGNIVYTGD
                     FKFDQAAREGYQTDLLRLAEIGKEGVLALLSDSVNATSNDQIASESEVGEEMDSVISD
                     ADGRVIVAAVASNLVRIQQVFDSATAHGRRVVLTGTDAENIVRTALRLEKLMITDERL
                     LIKPKDMSKFEDHELIILEAGRMGEPINSLQKMAAGRHRYVQIKEGDLVYIVTTPSTA
                     KEAMVARVENLIYKAGGSVKLITQNLRVSGHANGRDLQLLMNLLKPQYLFPVQGEYRD
                     LAAHAKLAEEVGIFPENIHILKRGDIMVLNDEGFLHEGGVPASDVMIDGNAIGDVGNI
                     VLRDRKVLSEDGIFIVAITVSKKEKRIISKAKVNTRGFVYVKKSHDILRESAELVNTT
                     VGNYLKKDTFDWGELKGNVRDDLSKFLFEQTKRRPAILPVVMEVR"
     gene            10591..11376
                     /locus_tag="VHC05_001504"
     CDS             10591..11376
                     /locus_tag="VHC05_001504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
                     /protein_id="HEQ5402797.1"
                     /translation="MASIAIEYHSVVLGMERKVNVIYPDQSEIPKKDQGDKDIPVLYL
                     LHGMGGNENSWQKRTAIERLLRHTNLIVVMSSTDLGWYTDTAYGLNYYRALSQELPQV
                     LAAFFPNMTQKREKTFVAGLSMGGYGAFKWALKSNRFSYAASFSGALDFSPETLLEGN
                     LGELAYWQGVFGQFDDPDLDKHYLKNMVAESDGKTKFYAWCGYEDFLFATNEKAIADF
                     QAQGLDIDYHKGHGKHEWYYWNQQLEVLLEWLPINYQKEERLS"
     gene            11406..11732
                     /locus_tag="VHC05_001505"
     CDS             11406..11732
                     /locus_tag="VHC05_001505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402798.1"
                     /translation="MKQLLAIILWLPKLIVKMFWHLIKGFLQTILLVTIIIIGLMYYS
                     NHSDSVLANKISIVTEQVVQIFDILTQKPSAKTRHGSGNSHSTFLVSAKEGNQRLKKS
                     SISFGN"
     gene            11778..13685
                     /locus_tag="VHC05_001506"
     CDS             11778..13685
                     /locus_tag="VHC05_001506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEQ5402799.1"
                     /translation="MIILQGNKLERSFSGDVLFQNISLQVDERDRIALVGPNGAGKST
                     LLKLLVGEETPTSGEVNTKKDLTLSYLAQNSRFESDQTIYEEMLKVFEALRQDEKRLR
                     QMEMDMATVSGQDLTRLMTDYDLLTEHFRQQGGFTYESDIKAILNGFKFDESMWQMTI
                     AELSGGQNTRLALAKMLLEKPELLVLDEPTNHLDIETIAWLENYLANYQGALIIVSHD
                     RYFLDKVATVTLDLTPHGLDRYVGNYSRFMTLKAEKLVAEEKQFDKQQKEIAKLEDFV
                     QKNIVRASTTKRAQARRKQLEKIERLDKPTSARKSAHMTFQADKPSGNVVLTVEKAAI
                     GYNQHVLSEPINLDVHKLDAIAIVGPNGIGKSTLIKSVIGQIPFIKGEVKYGANVEIG
                     YYDQTQSHLTSSNTVLEELWQDFSTTPEVDIRNRLGAFLFSGDDVKKSVAMLSGGEKA
                     RLLLAKLSMENNNFLVLDEPTNHLDIDSKEVLENALIDFDGTLLFVSHDRYFINRLAT
                     KVLEITENGSTLYLGDYDYYLEKKAELEELARLAAGETVEETKEASATDYQLQKANQK
                     ERRRLTRRYEEIEARLETIEERIGAIQEDMHASNDTAQLIAWQKEWDQLDQEQETLME
                     EWETIAEQIES"
BASE COUNT         4260 a         2342 c         2960 g         4312 t
ORIGIN      
        1 ggagggtaaa aatgctaaca tatgacgagt ttaagcaagc aatcgaccgt gaatatatca
       61 caggagacac agttatgatc gtgcgcaaga acggacagat ttttgattat gtgttgccgc
      121 atgaagaagt gagaaatggg gaagttgtga caatcgagcg gatatcagat gttatggcag
      181 aactttctga gtctgaataa ttttagttca ccaaagaatc aagaaagaac cattggggca
      241 aaattggggc ataagtttag aacttttgtc gtttcttgtg tcgatacaat accggtttaa
      301 tactaacaaa tgcttttatt atcgactttg tcaccattat tgttccttgt gttttttcgg
      361 gaatagcctc aagaagtgat taaataaaac attaaagagc cttgtcatat caattatcgt
      421 tgatatgaca aggttctttt gatagtttaa attgatgttt ttcattgtag gctcttatct
      481 acactttttt aaggcatctt tagaaggttt tgagcgtgac taagtattca cactttgact
      541 cataaaatga tagcatattt tctagagatt ggtataatag aaacaaagat ggaaaggaaa
      601 gagatagatg actcaattag caaccatttg ttacattgat aatggcgatt ctttgctatt
      661 attacaccgc aataaaaaag aaaatgatgt ccacaaaggc aagtggattt cagttggggg
      721 taagctcgag gctggtgaga ccccagatga gtgtgcccgt cgtgagattt tagaggaaac
      781 ccatttgact gttacagaga tggcctttaa aggaatcatt acttttccag aatttacccc
      841 tggtcatgac tggtatacct atgtttttaa agtaacagga tttgaaggag acctcatttc
      901 cgatgaagag tcacgagaag gaaccttgga atgggtacct tacgatcaag tgttggaaaa
      961 gccaacttgg gaaggtgatt atgacatttt taaatggatt ttagaagacc gtcctttttt
     1021 ctctgccaaa tttacctatg accaaaacaa ccaactcatg gataaatctg tgacctttta
     1081 ttgatttacc caggttacca gtaaaactta tcattttctc aaagaaagga accctatctt
     1141 aatgtcctta atacctgaaa agtctagaac agatagctta ttttacaaat ggtttttaaa
     1201 taatcaagct accatggctt tagtaataac acttttagcc tttttaacga tttttgtttt
     1261 tactaagatc tcttttttat ttatgccagt gatttctttt tttgcggtca tcatgttgcc
     1321 cttggttatt tcgaccattc tgtattatct gaccaaaccc ttagttgacc ttattaatca
     1381 cttgggcccg aatcgtacca cctctatttt tattgttttt ggtttgatta ccttactttt
     1441 tgtctgggcg atttcaggct ttgttcccat ggtacagacc caacttacca gttttattga
     1501 ggatctgccc aaatacgtgg gcaaggtcaa tgaagaagcc aataaacttc ttgaaaatga
     1561 atggttagtc agctacaagc cccaactcca agacatgctt acccatacaa gtcaaaaggc
     1621 tttggattac gcgcaaagtt tttcaaaaaa tgctattgac tgggctggta attttgctgg
     1681 tgccattgct cggattaccg tggctattat tatttcgccc tttattctct tttatttttt
     1741 acgagacagt agccacatga aaaatggcct tgtgaatgtc ttacctctca aattacgggt
     1801 gcctatggtt cgagtcttgg gagatattaa caagcaatta tcaggctatg tccaagggca
     1861 ggttacggtt gcaattgttg tcggctttat gttttctatc atgtttagcc ttgtgggact
     1921 gaaatatgcc atcacttttg ggattattgc tggctttctt aacatgatac cttacttagg
     1981 aagtttcctt gccatgatac ctgttgtgat tatggctatg gtacaaggcc catttatgtt
     2041 ggttaaggtg cttgttatct ttatgattga gcaaaccatc gaagggcgtt ttgtagcacc
     2101 gcttgttttg ggaaataagc tgagcattca tcctattacc attatgttct tgttattgac
     2161 tgcaggctct atgtttggtg tctggggtgt tttccttgtc attccaatct acgcttctgt
     2221 caaagttgtg attaaagaat tatttgactg gtacaaaaaa gttagcggtt tgtatgacga
     2281 agaagtattg gtgattgagg aggttaagga ccatgttaaa tagtgaaaaa atgattgctt
     2341 ccttggatca gcaagaccta gcgcacgctg aaaaatattt ccaaaaagct ttaaaagaag
     2401 atgatgcaga tagtttaatc gccttaggag aatacttaga aagtataggt tttttgccac
     2461 atgccaagcg tatttatttg cagttagctg atgattaccc agaactcaat ataaatttag
     2521 ctcagattgc agcagaagac gacgccattg aagaagcttt cttgtatttg gataaggttt
     2581 caaaagatag ccctaattat ttgtcagctc tcttagtcat ggctgacctc tatgacctgg
     2641 aaggactgac agaggtggcg cgtgaaaaat tgcttcaagc agtggccatc agctcagagc
     2701 cactggtcat ttttggtttg gcagaaatcg acatgtcctt gcagtatttt aaagaagcta
     2761 ttgattacta tgcacagtta gacaatcgtc aaatccttga attgacaggt atttccactt
     2821 atcaacgcat tggacgagcc tatgctagct tagggaaatt tgaggcagcc atcgaattct
     2881 tggaaaaggc cgtggccatt gaatacgaag atgaaactgt ttttgaattg gcgaccctca
     2941 tgtatgacca agaaaattat caaaaagcca atctttactt taaacagttg gaaaccatca
     3001 atccagatta tccaggttat gaatatggtt atgctttgag tcttcatgaa gagcataaga
     3061 cgtcagaagc tttgcgcttg gttcaacagg gcctacgtaa aaatgcattt gacagtcaat
     3121 tattattact agcatcgcag ctttcttatg aattacacga taggcagaat gctgaaaatt
     3181 acctgcttca agcaaaggaa gtagctgttg atgacgaaga gattctcatg cgtttagtga
     3241 ccctttattt tgatgccgag cgttttgagg aggttattgc tcttaatcgt gagacgattg
     3301 ataatgtctt aaccaaatgg accattgcaa aggcttacca cgccttggaa caagaagaag
     3361 ttgccttggc tctttataat gagatttcgg ctgatttggc agaaaatcca gagtttttac
     3421 aggattatgc ctatttatta agggagtttg gccagtttca caaggctatc caaatggcta
     3481 ccgcttacct cagacaagta cctgatgatg tgaatatgca agactttctt gaccatatca
     3541 agcatcaaca atcagaataa aaaaacagtt ctcctagggg aaataacttt cctaggagag
     3601 ctgtttttta gttgcttatc agaataattt catagagaga attttggctt ggtcaggagt
     3661 aacccgtaag gttttttgac cagtataagt cacaaatcct ggcttggcgc cactaggttt
     3721 gtgtaatttt ttagcttcaa tcatatcgac ctgaacgaga tttgataacc tagctttcga
     3781 ataataagca gctagttcgg cagcatcagt tttaacctcg tcacttgggt caagattgtc
     3841 tttgatgatg acatgacttc cagggatatc cttagcatgg aaccagagtt ctcctttttt
     3901 agccatttta aaggtgagtt cttcattttg caagttattg cgtcccacca tgagaatggt
     3961 ttttccatct gaagccaggt actgctcagg ctttttacgt ttatggcgtt tgtctctttg
     4021 gcgacttttc aaaaagccag cctgatataa ttcttcgcga atatcttcga tgtcgtcgat
     4081 acttgcttga gataaattgt agtccacgct ctcaaagtaa gtaatacttt gcttggtatc
     4141 ggcaatcagt ccagataagt gtttgacagc ttcttttagc ttttggtatt ttttaaaata
     4201 acgttgagca ttttgatttg gtgtcagagc cttgtctaag gcaatctcaa ttttttcccc
     4261 tgtataataa ttgtctaaaa tcacagagtc ttggttgttt gggaccagac tgaggtaggt
     4321 ggtcaataat tctccttttt gacggaataa ttcagcattt ttcgtagcca aaagttcagc
     4381 ttcttgttta cttagtttgt tgcgattttt gtccagttca gtttgcacac ggtgaatcaa
     4441 atcactggct tgctgattga tacggtcgcg ctcagccttg tcttgataaa agtggtcaag
     4501 catgtcagac aaagtctcaa acgtcgcatg gctatctgag aaaagaacag gcgcaaaaga
     4561 agctgtggtc agatttgcct gagtaggtct agcaaaaaac tcacggaacc gttttaattt
     4621 gtctgtggtc agaagctcgg ccaactcttt tgcggtgtct cgccctaagc cttgaaaatg
     4681 ctgttgcaat cttttaactg ttagttcttg tgtttggagg atttcaaata gaggaacatc
     4741 tgtaattgta aaaggattaa cagcagctgt tttagggggc tcaatgtagg tagagccagg
     4801 taaaatggtg cggtaagagt tttgtgaaaa gccaacatgt ttaatggatt cgatgatttt
     4861 attttctgca cggtccacca agatgatatt gctgtgcttc cccatgattt caatgattag
     4921 ggttgcctga atagcatctc cgatttcatt tttattagat accttgattt cgataatgcg
     4981 gtcattatca atctgttcta actgctcaat gactgcaccc tggaggtatt tacgcataat
     5041 catggtaaag gtattaggta cctgaggatt ttgaaagtcc gcttgggtaa tttgaagtcg
     5101 tccaaaaaca ggatgggcag acaatagcaa tttataattc ttgcgatggt tacgaatggt
     5161 taagacaagt tcccgttcaa agggttgatt gaccttttgg atacgaccgt aaagcaagtt
     5221 ctcttttaat tcgttggtta aatggtgtaa gaaaaagccg tcaaaagaca tggtttctcc
     5281 tttctgaatt ctaatctctt cattatacca caaatacttg actaaaaata tggacgaaag
     5341 agcttgcaat ttttttgatt taggttataa tgttaaaaaa acgagaaagg aagtcaatga
     5401 tggtaaaaac acaacactta gcaaattggc aaagctggca tagataagtt gtgtttatga
     5461 attggcatag atacgacttt tagagtactt ctaaaaagat atctatgcgc tgacattgga
     5521 tttcacaaga gcgcctagta atcattacta agtgcttttt cttttgagaa gtattctcat
     5581 catcaacgtt ttaaagagat tgacatgaaa tgtgaggaat tcagatgaaa aacaagagtt
     5641 taatagctac cctccttgtt ttaactgtaa tagtgatagg ctctctatta tcaaaaggag
     5701 tatcaaagga aaaccgtgat ttggctaacc aacaaaacat tacaattggc atcttacaat
     5761 tggttactca tgaggctctt gatgatatta agcgaggtat tgaagatcaa ctcaaaaagc
     5821 agaagcctca aaaacaaaat gtagtgatta aggttatgaa tgctgagggg gatcagagta
     5881 aaatccaaac aatgagtagg caattagtgc aatcgggaag tgatatcgtg attggtatcg
     5941 caaccccggc ggcgcaaggc ttagcagctg ccagcaagga tatcccagtt gtcatgtcag
     6001 cagtatctga tccagtagga tctagattag tgatgcaatt ggatcaacct gaagctaatg
     6061 taactggtct atctaataaa gtgcctgtta aacagacaat tgatttaatg aaaaagctga
     6121 caccacatgt caaaacagtt ggaattttat atgcaagtaa tgaggataat tccttatctc
     6181 aagttaaaga gtttaggcgg ttagctcgca aaaagggcta tcaagttatt tcatacgcgg
     6241 ttccttctac taacgaagtt cctgccacga tgtcagttat gttaggtaaa gtagacgcgg
     6301 tatttatccc ccaagacaat actatagcaa gtgcattttc atcagtcatg acaaccagta
     6361 aggctgcaaa gattcctgtc tacactagcg ttgatcgaat ggttgaaaaa ggtggtttgg
     6421 cagctatttc tcaaaatcag tacgatttgg gagttcaaac agctaatcag gtgttaaaat
     6481 taatcaaagg aaagcgtgtt gtagatgttc ctgtcaaagt tgtggatatt ggtcaaccgc
     6541 taattaataa gaatgtagca gcagaattag gtattgctat taacagggaa gattttcctt
     6601 cagcttcttt tattgagaat taatacaatg acatgtgata taaaaggtca agaaaaaacc
     6661 ataaaaaaca ccctcactga ggtgaatttg gatgccaagt cagacaatcg tcttgaggat
     6721 gtaatggtta tttttatcat ttttagtttt aaaatgctct attttagaca cgtaaaaaat
     6781 cttgcctttt gagtaagttt aaacatgatt ctcgactttt ttgttttctg tcttagtttc
     6841 gtcaaagtga ttgaaaaaaa agactaagcc acggtgctga actaagtata aaacaaatct
     6901 aaaaattaat gtaaagaaag ggtttatact ggcgagcgtt acccgctaat ataaatatga
     6961 ggaaaaatat gattatttca tcagtttcac aaggccttat atggggagtt ttaggattag
     7021 gaatctacct gacctttagg attttaaact tccctgacat gactacagaa ggttcttttc
     7081 ctttaggagg agctgttgcg gtcaccgcta ttagcttagg gtggaatcca tttctatcaa
     7141 ccttacttgg tatgttatca ggtgctttag caggttttct aacagggctg ttatatacga
     7201 aaggaaaaat gccaacactt ttagctggaa ttttggtgat gacgtcatgt aactccatta
     7261 tgctaatggt aatgggaaga gcaaacttgg gtttacatga tcataaacgt attcaggatt
     7321 gtttcccttt ttcaattgat ttaaatagcc ttttaacagg tctgataact gttgtgattg
     7381 ttattagcgt tttgatctat ttcctttaca ctaatctagg tcaagcttat attgctacgg
     7441 gagacaataa agatatggct aagagttttg gtattaacac ggattggatg gaagttatgg
     7501 gacttgtggt ttctaatagt ttaatagctt tatcaggtgc tctagtgagt caacaagatg
     7561 gctatgcaga tgtctcaaaa gggattggag ttattgttat tggtttggcg agcataattg
     7621 ttggtgaagt actatactca actggactga ctcttttaga acgtttgatt gctattgtaa
     7681 taggctcgat tctttatcaa tttttaattt cagtagttat tacgctaggt tttaatacaa
     7741 gttatttgaa attaattagt gctcttgttt tagcactgtg cctcatgata ccagtggtaa
     7801 aagagcgctt ctttaaggga gtgaggttaa cacgatgaca aaaattattg aattgatcaa
     7861 tgcaacagtt gacgtagata atggttttga agatgctaaa acaatattgg acaatgtgac
     7921 actaactatc tatgaacatg attttttaac tattttagga ggaaatggag ctggaaaatc
     7981 aacccttttt aatgtaattg caggaacgct aagtttgaca cgggggcaaa ttaggattct
     8041 tggtcaggat gtgacgcatt ggccggcaga aaaaagagct ctttacctat cgcgagtctt
     8101 tcaagatccc aaaatgggaa cagcccctcg gatgacagtg gctgaaaatc tcttaatcgc
     8161 acgtcaaaga ggagaaaaac gctccttggc ttctcgaaaa ataacagagc acttagctag
     8221 ttttgaggat ttggttaaac gaacaggaaa tggcctagaa aagcatttag aaacaccagc
     8281 aggtcttttg tctggtggac aaagacaggc tttaagttta ttaatggcaa cgttgaaaaa
     8341 gccagctctc ttattattag atgaacatac ggctgccctt gaccctaaga cgagtcaatc
     8401 tttaatgcaa ttgacagatg agtttgtgac aaaagatggt ttaacagctt tgatgattac
     8461 ccaccatatg gaagatgcat taacttatgg gaatcgtctg attgtaatga aagatggaaa
     8521 cattattaaa gatttaaatc aaatggaaaa agaacaaatg acgattactg actattacca
     8581 actatttgat taatcaacga tctaaatcat tgacgaataa taagtcagtg attttttgat
     8641 ttccgtactg aaaataatct gaaagtatca aggctattta gagaaaaaac gcctcaaata
     8701 tgatatacta tagaagatag tagcatagct acataacagt aattcgactt acgttgtaag
     8761 gaccgtttgt aataataaaa tatttaaagg agtatcatga ctgatattaa aatgattgcc
     8821 ttgggagggg tccgtgaata cggaaaaaac ttctatttgg tagaaattaa cgattctatg
     8881 tttattttag acgcagggct caagtacccc gaaaatgagc aacttggggt agatttagtc
     8941 atccccaatt tagattatgt aattgaaaac aaaggtaaag tacaagggat tttcttgagt
     9001 catggccatg ctgacgccat cggagccctt ccttatttgt tagctgaagt atcagctcct
     9061 gtatttggat ctgaattgac tattgaatta gccaagctat ttgtgaaaag taataacagc
     9121 actaagaaat ttaataattt tcatgtggta gacagtgata ctgaaattga atttaaagat
     9181 ggcctagttt cgttctttag aacaacgcat tcaatcccag aaagtatggg tattgttatt
     9241 ggaacagata aaggaaacat tgtttatacc ggtgacttca aatttgatca agcagcaaga
     9301 gaaggttatc agacggattt gctacgttta gctgagattg ggaaagaagg ggttctagct
     9361 cttttatcag attcagtcaa tgcgacaagc aacgatcaga ttgccagcga atctgaagtt
     9421 ggtgaagaaa tggacagtgt tatctctgat gctgatggcc gtgtcattgt agctgcagta
     9481 gcctcaaatc ttgttcggat tcagcaagta tttgattccg ccactgccca tgggcgtcgt
     9541 gttgttttaa ccggaacaga tgcagaaaat attgtcagaa cagctttacg tctagaaaaa
     9601 ttaatgatta cggatgagcg tcttttaatt aaacctaagg atatgtctaa attcgaagac
     9661 catgaattaa tcatccttga agctggtcgt atgggtgagc caattaatag cttacaaaaa
     9721 atggcagcgg gacgtcaccg ttatgttcaa atcaaagaag gagaccttgt ttatattgta
     9781 acaacaccaa gtacggctaa agaagctatg gtggcgcgtg ttgaaaactt gatttacaag
     9841 gccggtggtt ctgttaaatt aatcactcaa aacttacgcg tttcaggcca tgctaatggg
     9901 cgtgatttgc aactattgat gaatttgtta aaaccccagt atctttttcc agtacaagga
     9961 gaatatcgtg atttagctgc ccatgcaaag ctagctgaag aagttggtat ttttccagag
    10021 aatattcata ttctgaagcg tggcgatatc atggtgctta atgacgaagg ttttctccat
    10081 gaaggaggtg tacctgccag tgatgtcatg attgacggta atgctatcgg tgatgtgggt
    10141 aatatcgttt tacgagaccg taaagtcttg tcagaagatg gtattttcat tgttgctatt
    10201 actgtttcta aaaaagaaaa acgcattatt tctaaggcta aagttaatac gcgtggattt
    10261 gtgtatgtca agaaaagtca tgatatttta agagaaagtg cagaattagt taatacaact
    10321 gttggcaatt acttaaaaaa agataccttt gactggggcg aattaaaagg gaatgtcaga
    10381 gatgatttgt ctaaattctt atttgaacaa accaaaaggc gcccagcgat tctgccggtt
    10441 gtgatggaag ttcgttagtg aaaataggaa ggttaggcaa aaactgccta ccttctttga
    10501 ttttaacaac tggtaaacca ggaaactgtt cacccaaaaa tacagtagat ttacgtgata
    10561 ggattatttt ggtataaagg agtgtaatga atggcaagta ttgcaattga ataccattcg
    10621 gtagttttag gaatggagcg taaggtaaat gtgatttatc ctgaccagtc tgaaatccct
    10681 aaaaaagatc aaggggataa ggatattcct gttttatatt tgttacatgg tatgggaggc
    10741 aatgaaaact cttggcaaaa acgaacagct attgaacgct tgttgcggca taccaatttg
    10801 atagtcgtta tgtcttcgac agacctaggt tggtatacag acacggctta tggacttaac
    10861 tattatcggg cgttgtcaca agagttaccg caggtcttag cagctttctt tcctaatatg
    10921 acccagaaac gagaaaaaac ctttgttgct gggctctcta tgggtggcta tggtgccttt
    10981 aagtgggcac tcaaaagcaa tcggttttct tatgcggcat cgttttcagg cgctttggat
    11041 ttttctcctg agaccttgct tgagggaaac ctgggagaat tagcctattg gcagggcgtt
    11101 tttggccaat ttgatgaccc tgaccttgac aagcattacc ttaaaaatat ggtggcagaa
    11161 agtgatggaa aaaccaaatt ttatgcttgg tgtggctatg aggattttct ttttgccact
    11221 aatgaaaaag ctattgctga ttttcaggct caaggtcttg acattgatta tcataaaggt
    11281 catggtaaac atgagtggta ctattggaac cagcaattag aagtcctgtt agagtggtta
    11341 ccgataaact accaaaaaga agaaaggttg tcttaaccat ttcctagtac aacatgaggt
    11401 gacaaatgaa acaattactg gcgatcattt tgtggctgcc taagctaata gtgaaaatgt
    11461 tttggcatct tatcaaaggg tttttacaaa ctatcttatt agtaacgatt attattatag
    11521 ggctgatgta ttattctaat cacagtgatt ccgttttagc caataagatc tcgatagtta
    11581 ctgagcaagt ggtgcaaatt tttgatatct taacacaaaa gccatctgca aagacgcgtc
    11641 atgggagtgg taatagtcat tccactttcc ttgttagcgc taaagaaggt aatcaacgac
    11701 ttaaaaagag ttcgatttct tttggaaact aggctgaaaa tgtcctcaaa agggcatttt
    11761 tttgttagaa tgaaagtatg attattttac aaggaaacaa gttagaacgc tctttctcag
    11821 gagatgttct ttttcaaaac atatcactgc aagttgatga aagagacaga attgcattag
    11881 tagggccaaa tggagctggt aagtcaacct tactcaagct attggttggg gaagaaaccc
    11941 caacgagcgg agaagttaat actaaaaaag acctaacctt gtcttatctg gctcaaaata
    12001 gccgctttga atcagatcaa acaatatatg aggaaatgct caaggttttc gaagcattac
    12061 gccaagatga aaagcgcctg cgtcagatgg aaatggatat ggcaaccgtt tcaggtcaag
    12121 atttaacccg actgatgaca gattatgatc tgcttacaga gcattttcgt cagcaaggcg
    12181 gctttacgta tgaatctgac atcaaagcca ttttaaatgg gtttaagttt gatgagagca
    12241 tgtggcagat gactatcgct gagctgtcag ggggtcaaaa tactcgtctg gccttggcta
    12301 aaatgctttt agaaaagcca gaactattgg tccttgatga gccaacaaac cacttagata
    12361 ttgaaaccat tgcctggtta gagaactact tggccaatta tcaaggagct ctaatcattg
    12421 tgagtcacga ccgttatttt ttggataagg tggcaacagt gaccttggat ttaactcctc
    12481 atggattgga tcgctacgtt ggcaattatt ctcgttttat gactttaaaa gctgaaaaat
    12541 tagtagccga agaaaagcag tttgacaaac agcaaaaaga aattgccaag ttagaagatt
    12601 ttgttcaaaa aaatattgtc agggcttcaa ctacaaaacg tgctcaggcg agacgtaagc
    12661 aattggaaaa aatagaacgc ttagacaaac cgactagtgc tagaaaatca gctcacatga
    12721 cttttcaggc agataagccg tctggcaatg tggtgttgac ggttgaaaaa gctgctattg
    12781 gttataacca acatgtttta tctgagccta ttaacctaga cgttcacaaa ttagatgcga
    12841 ttgctattgt tggtccaaat ggtattggta aatccactct gattaaatct gttattggac
    12901 agattccttt catcaaagga gaagtgaaat acggtgccaa tgttgaaata ggttactatg
    12961 accaaaccca gtcacatttg acgtctagca acacagtttt ggaagaatta tggcaggatt
    13021 tttcaactac gccagaagtc gatatcagaa accgattagg ggcttttctc ttttctggag
    13081 atgatgtcaa aaaatcggtg gccatgctgt caggtggaga aaaagcccgt ctgcttcttg
    13141 cgaagttatc tatggaaaac aacaattttc ttgttctgga tgagccgact aaccacctag
    13201 acattgacag taaagaagtg ctagagaatg ccctcattga ctttgacggc accttgcttt
    13261 ttgtcagcca cgaccgctat ttcattaatc gtttggcaac taaggttctg gaaattaccg
    13321 aaaatggctc aaccctttac ttaggtgact atgattatta ccttgagaaa aaggcagagc
    13381 tagaagaact agcccgccta gcagcaggag agacagttga ggaaacaaaa gaagcctctg
    13441 ccactgatta tcagctacaa aaagctaatc aaaaagagcg tcgtcgcttg acccgccgat
    13501 atgaggagat tgaagcaaga cttgaaacca ttgaagagcg cattggtgct attcaagaag
    13561 acatgcatgc ctccaatgat acggcgcagt taatcgcttg gcaaaaggaa tgggaccaat
    13621 tggatcaaga acaagaaact cttatggaag aatgggaaac catcgctgaa caaatagaat
    13681 cataaaaata agctttagca gttttgctaa gcttattttt atcgctttgt tacttgtttg
    13741 aaggtgtgaa agagttttta aaatgatgtg tttttttatg tcaaggtcgg taaaacgtga
    13801 aactgttata tagtattttt aaatttttta gtacagtttt gtttgtaatt tcacaaacta
    13861 ttgcatttct aaaa
//
LOCUS       DAUDWO010000046        13687 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.047, whole genome shotgun sequence.
ACCESSION   DAUDWO010000046 DAUDWO010000000
VERSION     DAUDWO010000046.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13687)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13687)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13687
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.047"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            21..1568
                     /gene="sfbI"
                     /locus_tag="VHC05_001507"
     CDS             21..1568
                     /gene="sfbI"
                     /locus_tag="VHC05_001507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011527444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibronectin-binding protein SfbI"
                     /protein_id="HEQ5402800.1"
                     /translation="MVSSYMFVRGEKMNNKMFLNKEAGFLAHTKRKRRFAVTLVGVFF
                     MLLAYAGAIGFGQVAYAADEKTVPNFKSPDPDYPWYGYDAYGKGYPGYDISKYYHDLR
                     VNLNGSQVYQVYCFNIQKIFPYNVKSVTQKWFKKVEGNSDTFGLYAMNPRVQGEELSQ
                     KLRSVMYNAYPKNANNIMDGLDTLNAIKVTQSAVWYYSDKSEFEVDKQWESELNNHEI
                     DQEQVTLMREALRKLISSNLEETVEKKLPENYKLNIFNPQDTSIQHLLSAEFVPENPP
                     RPGETPEYGPKTPELDGSPIPEDPKHPDDNLEPTLPPVMLDGQEVPEVPSESLEPALP
                     PLMPELDGQEVPEKPSIDLPIEVPRYEFNNKDQSPLAGESGETEYITEVYGNQQNPVD
                     IDKKLPNETGFSGNMVETEDTKEPEVLMGGQSESVEFTKDTQTGMSGFSETATVVEDT
                     RPKLVFHFDNNEPEVEENREKPTKNITPILPATGDIENVLAFLGILILSVLSIFSLLK
                     NKQNNKV"
     gene            2366..2506
                     /locus_tag="VHC05_001508"
                     /pseudo
     CDS             2366..2506
                     /locus_tag="VHC05_001508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004224222.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
     gene            2778..6881
                     /locus_tag="VHC05_001509"
     CDS             2778..6881
                     /locus_tag="VHC05_001509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibrinogen-binding adhesin SdrG C-terminal
                     domain-containing protein"
                     /protein_id="HEQ5402801.1"
                     /translation="MYSRLKRELVIVINRKKKYKLIRLMVTLGLIFSQLAPPFGTLMA
                     LSGHSRSKSPVTEVKADNVSTLKTGSFKLKKFDEDGKTPIKDVTFQLTSETNPSNYKI
                     EQITSGAGDASFANIPPGTYLLKEVAPPSGYQVMADYYRITVSPDGYTQYTYVKVGTT
                     TSSPTTSLPSTSGGGTGGTVFRTSKTSGVVTVTDYNFTTKNKAQGNTDYTTLWATSGE
                     FFDMSFKLKVNEGTQAGDSFTIKLSDYLSPNGIREKFISAPPLMLDKKVVATGIYDES
                     TNSYIYTFNDLINHKQNAEITVNYTFSPEAKKVDRDWYVNTYNITNIIDGQKQDSGNF
                     TIDYGQGQYMTGTLNSGLRLRNNITYLNRTTGEVEYTIYLNNGASPRDKDFTVKNPVT
                     GRHFLNLEDKSASVAFTQKNITVYRVPLSQKTSKMPYSMSGETDGLESIPFDYSSKGI
                     TFTKESFHDNETNSNTAGLLIKIKAYITADNKRSADVSLSAGWTYTNLIRSRSDAKAS
                     AFELGNTSSGVANNIEPTVTIRNYKIKKGSIVFTKQDVETKMTLSGVAFRLEKKEEND
                     WQIVEKYKDVQTGTEGKLILSDLDPGEYQLIETKPLDGYLVSSGPVVTFTITDQGTEG
                     TVKPSDKIIPNTKPGKQKIKVIKKDEQSRVPLAGAKFQLESNKGVVLTGETDGKGEYT
                     FTNLPFGDYILTEIAAPKGYILDKTPRSIAIGDTVDKEPEPTVVEAATPRTVRSVSPS
                     ATVSDKDVSRNILVKKVEFTTTNGQTPLQVKPNQGENLIARSEFELKKEIDIKKGDYF
                     AVKLSDNIDPFGVSTGETTTFNITGPYGTLAVGKYDSKSRSIIYTFTDYVEKYEVSNF
                     STILPYFIDRYAVTRDADINISTSVGSQTNTARVRVLYTPYYGATDSYSPVNIGSMIT
                     KLDEKNGTFTNYIYINPMQQFIRNGKLTFQGGGSAIIDNETQVTLFKVNNSTDMPPSW
                     GITDSTLRVENDILVNKKQGEISVDFENILEARNSFIMKVVGKIASSGTSVRTSATLS
                     QKYDNTYGYYSTNGRWIPKGPYSEYYRYDTTAILHSGDSNVDGAIRISVTNRKNSVAF
                     TKTNGLEKPLEATFELRRLNSNKTFTSVKTTKSTKDTGKFSFEGMESGSYEVWETQSP
                     EGYLKPDKAVATFKVDKDGTIKDLTPDNGKIINYPNTAKIIFTKILASEKEELSPATK
                     EKSATFSLWRLKEESLKETNTVSQAYDEQYYEPVMENNSVRTVTSDSSGNVLFDKLSP
                     GFYAIKEEKAPDGYVKQQGIVRIFQVDSSGKVIKYQYFKDKSIAGKLTEITDLETEQL
                     KQFNEIINKKFVFPMTGGQGIALLMIIGGTMMGIAYFGHRRKQRLND"
     gene            7002..9164
                     /locus_tag="VHC05_001510"
     CDS             7002..9164
                     /locus_tag="VHC05_001510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isopeptide-forming domain-containing fimbrial
                     protein"
                     /protein_id="HEQ5402802.1"
                     /translation="MKTKIFSRLAAVLLVLGSLLPTVVAVAEAESSHKTDVVIHKIKM
                     TSLKGWPKEKNPDGTYTGLGDKNYNGEKIDTITSYFGEGAEELDGVSFTYWSVDKEKY
                     KKLTKNPQNYDTVPKMKAFLQGTEKNKALENSSETIDGKTTGHTADKGGVKVKDLADG
                     YYWFVENSGSNIANGETLSSSAAVPFGLELPVYKADGSTITELHVYPKNTTTKPKIDK
                     NFSKDEKDAALAGGANYDYYQKDKGYVSRIIGSEVSYQIKTEIPAGAQYQTLRWEDTM
                     TKGLTYKAGSLELTITTKGDGKAALNFEFQTDYKLTENQSGFVLKFTESGLEKVKKAV
                     QATKDAKGQVTADGHPMTVDISYKATVNSDAVVDQPDKNTVIFDYSNNPKEHKDPREK
                     STKPKDKQITVEKTWASQSAPTGIAVTYYLYQKGDESGKDKVVDSVTLTTDYKHIFTN
                     LDDSKDYYVKESAIGYTPEYTEAKDGKISIKNTKDDKNPDPLKPTSPAIVTHGKKFVK
                     TSQDDERLKGATFVVVDQKTNEKYLAIKADEKQSAEEKAYHDTEQKYQDEVKKATTEK
                     PNSQAIEKAKKARDDAFKKARTAYEWVSDKQKAVKFTSNSKGQFEVTGLAAGTYYLEE
                     VAAPTGFAKLQEKVEFTLGFNSYNGHKDQSGQSLEGHTQYEKGTPDFGYGQRVINKKI
                     TIPQTGGIGTVIFTVVGLAIMTVTGLMMIRRNKNDKSE"
     gene            9177..10022
                     /locus_tag="VHC05_001511"
     CDS             9177..10022
                     /locus_tag="VHC05_001511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prealbumin-like fold domain-containing protein"
                     /protein_id="HEQ5402803.1"
                     /translation="MGGTQLKIGRLIRLMLSICACLYFLTSPIFALQKTSSVTIHFEN
                     SDKDTQLALWQLPEGQTLPELETLFEKTDAELTRQYPQVSTVTVPKGETKLVLSNLPV
                     GAIYYVREAEERLGVRSLAPFILKVDTDDDQAVYTKKAKAQKRGSYPFVKVSAQGGSL
                     EGATFEVWKQTQKQLQPVIKGSSRYLLTSSKDGSFMARDLPFGSYVLKEITAPKGYLL
                     SKKTIPFEVTDYSEKQAPVKVVNQPKIPPRIEIPYTGNAIMILVVLLGFALFTLGVYL
                     VRRNG"
     gene            10104..10976
                     /locus_tag="VHC05_001512"
     CDS             10104..10976
                     /locus_tag="VHC05_001512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001832654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class C sortase"
                     /protein_id="HEQ5402804.1"
                     /translation="MKKQSKRHRLNQNIALIVVFLIGLTILLYPQISRIYYTIESNYQ
                     SKQFDREKSTLHQEDISQRIALAKAFNASLHDVDLKDPYSDDEKTKGRAEYARMLELH
                     EQIGHVEIPKIRVDLPIYAGTSDEIISKGSGHLEGTSLPVGGENTHTVLTSHSGLPSA
                     KLFSDLAKLKKGDIFYIHNIKEILAYQIDQIKIIEPDNFSDLLIVPGKDYATLLTCTP
                     VGINTHRLIVRGHRVPYVSNEHKNNKQKASSGYMCYLFVLLALLTLLFGYWFYRQKKK
                     KSQKVKREEFHAKE"
     gene            10963..11796
                     /locus_tag="VHC05_001513"
     CDS             10963..11796
                     /locus_tag="VHC05_001513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012027974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class C sortase"
                     /protein_id="HEQ5402805.1"
                     /translation="MLKNKQSLSLRERLIQVMFPLLFLMGCLIVLYPLMSNYYYRVKQ
                     NQAVTSFESAKVIVNKDDIKRRMALARAYNATLDPGRINDPYTDLEKKGVAEYARMLE
                     LNEQIGYVEVPRFDINLPIYAGTSDDVLQKAAGHLEGTSLPIGGDSTHTVITAHTGLP
                     QAKLFTNIHKMKKGDLFFIHNIDKTLAYKVDQILVVEPDNFTPVLVKNGFDYATLLTC
                     TPYGINSHRLLVRGYRVPYQKAFEKADAQRPWYTKVIFLVSFLLFVILVIILLIDWHR
                     K"
     gene            11816..12673
                     /locus_tag="VHC05_001514"
     CDS             11816..12673
                     /locus_tag="VHC05_001514"
                     /inference="COORDINATES: protein motif:HMM:NF033745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class C sortase"
                     /protein_id="HEQ5402806.1"
                     /translation="MSKQKCVGYVLMILGLGLPLFFLTLMSLNQFQEQVAYQKFQTEN
                     RSWKNSQKEWVNRHNQEQALADRATTDPFVDAQNQLKQSPFDDNIIGYIIIPKLRMAQ
                     PIRVGASERHLEKGVAQVTGTSLPIGGLGTRSVIAGHRSWYDNERFLRIAELSLGDQI
                     VIDLGVYQLEYRVKSVEIIDAKDWRQLTAKKSQDLITLLTCNPLYPPFNERLLVNAER
                     VLPSLSDLPTKTRNKMDQSQLESPLASHKTSLVKLPLVLPFGIWVCLGWLIESYFIYR
                     LFRQCKGDS"
     gene            complement(13015..13674)
                     /locus_tag="VHC05_001515"
     CDS             complement(13015..13674)
                     /locus_tag="VHC05_001515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402807.1"
                     /translation="MKRCNKYLFTSLLAASMLFSSYKSVHAHDNIDEEGKVHLYWQGN
                     YYVDNYVDYTKKLVNNSIEWTVTFNSAKEQWVYPDFSVFLPKGVKAPKEITYEHHYGN
                     GTVDSKKRSNTQWHYDWEKQKTNFNQEFDKFPGYTGWSRSLDKFYKLKNEGKFSHVLV
                     DTYGRQSHTYFSHKMVWKFKTELEDNYKDKWNKLPFIAGIKQNNPLAASFPSYKGEFG
                     E"
BASE COUNT         4709 a         2338 c         2816 g         3824 t
ORIGIN      
        1 atatctttct tgacaataac atggtaagct catatatgtt tgtgagagga gagaaaatga
       61 ataacaaaat gtttttgaac aaagaagccg gttttttggc acacacaaaa agaaaaaggc
      121 gatttgctgt cactttagtg ggagtctttt ttatgctttt ggcatacgcg ggtgctatcg
      181 gttttggtca agtagcctat gctgcggatg agaagactgt gccgaatttt aaaagcccag
      241 atccagatta tccctggtat ggttatgatg cttatggtaa ggggtatcct ggatatgata
      301 tcagtaagta ttatcatgat ttaagggtaa atctaaacgg aagtcaggtc taccaagttt
      361 attgctttaa tattcaaaaa atttttccgt acaatgtgaa aagcgttact caaaaatggt
      421 ttaaaaaagt tgaggggaat tctgatactt ttggacttta tgcaatgaat ccaagagtcc
      481 aaggagaaga acttagtcaa aaacttcgaa gtgtcatgta taatgcttat cctaagaatg
      541 ctaataatat tatggacgga ttggacactt tgaatgccat aaaagtaacc caaagtgcag
      601 tgtggtatta ttctgataag tcagagtttg aggtagataa acagtgggag tctgaattaa
      661 ataatcatga aattgatcaa gagcaagtaa ctttgatgcg tgaagctcta agaaaattaa
      721 tttcttctaa tctagaagaa acagtagaaa aaaaattgcc tgaaaactat aaactgaata
      781 tttttaatcc acaggatact tcaattcaac accttttaag tgctgagttt gtaccagaaa
      841 atccccctag acctggagaa acccccgaat acggacctaa aactcccgag ttggatggta
      901 gtcctattcc cgaagaccca aaacatccag atgataattt agaacctaca ttgccgccag
      961 tgatgctaga tggtcaagaa gtcccagaag ttccaagcga gagcttagaa cctgcgcttc
     1021 ccccattaat gccagaacta gatggtcaag aagtccctga aaaacctagt attgacttac
     1081 ctattgaagt tcctcgttat gagtttaaca ataaagacca atcgcctcta gcgggtgagt
     1141 ctggtgagac ggagtatatt accgaagtct atggaaatca acagaaccct gttgatattg
     1201 ataaaaaact tccgaatgaa acaggttttt caggaaatat ggttgagaca gaagatacga
     1261 aagagccaga agtgttgatg ggaggtcaaa gtgagtctgt tgaatttacg aaagacactc
     1321 aaacaggcat gagcggtttc agtgaaacag cgactgttgt tgaagatacg cgtccgaagt
     1381 tagtgttcca ttttgacaat aatgagcccg aagtggaaga gaatcgggaa aaacctacaa
     1441 aaaatataac acctatcctt cctgcaacag gagatattga gaatgttttg gcctttcttg
     1501 gaatccttat tttgtcagta ctttctattt ttagcctttt aaaaaacaaa caaaacaata
     1561 aagtctgacg taaaagtatc ccataagaaa tagtgcgcaa atatgctgaa tagtggataa
     1621 ctgctacagt caagacaagc gttaattcaa aaagtactac ctatacacct gataataata
     1681 aggtgacaga taattcagag caagtaggat ggctaaaaaa tggtgtattc tatgtataat
     1741 agacttacaa gaaatcaagt tattgttaaa cgtcgtaaag cttaacgctt tcaaaagtcg
     1801 aaatcaatcg agactgtctt tatgcagtct cgatttttaa gtacgacaga catgttgtac
     1861 gtctgaggtg aaaatcctcc gtggacaccc gctaaaggtg aatccaaaag cgatgcccaa
     1921 gtctgactat cgtgagtagt ggggagagga agggagagtg aaatcgtggc tctacaaaca
     1981 gaaacgtgat atcaaggcgt atatagcgga tgagtctaaa gtccaaaaaa gtagtagtaa
     2041 cctataggcg taaatatgag agtaaacgag aaaagatgta caccttatcc tttgaggtct
     2101 catgagcgtt ctagacgtag taacaacgaa tgatgagaag tcagccgatg ccatagtagc
     2161 gatgaaactt ctgtaatgga agtagagcga agggctaaac aattaaccga atatgcctac
     2221 ttcacttgtg tatgtaaaac tagcggtctg atagaactgg atgcggtcac gtattgacta
     2281 gaggaaagtt cactaatata agatgtccct cagacaccaa aataagaaag gaatacgcaa
     2341 agaggagtgg aaaagtcgtc cacaatcaag atggagcgac cattgtcaat tagtagctta
     2401 aaattcagtt ctaaaacaag ctatatcaaa aacagtcctc gcaaaacggg gactgttttc
     2461 ttgcttggat gactacttag aacgacatgc gttaaaagtt cattgaaccg ccgtgtgccg
     2521 aacggcacgc acggtggtgt gagaggggct agaaattagc ccctactcga tttctatcta
     2581 agctaaaaat agaaatcaaa ttaaaagact agaaaataaa tttcagagtg cttggaaata
     2641 tctccaaata aacatttttc tcaaaaatga ggttttcatg taagaaatat ggagaaaaaa
     2701 atgagcttac aataatctaa agtaaatgta gttatgataa attaaatatg ttagaaactg
     2761 tatttttgta aagtttaatg tacagtagat tgaagagaga gttagttata gtgataaaca
     2821 gaaaaaagaa atataaacta attagactga tggttacctt aggccttatt ttttcgcagt
     2881 tagcacctcc ttttgggact ttaatggctt tatcaggaca ttcgaggtca aaaagtcctg
     2941 tcacagaagt caaagctgat aatgtgagta ccctgaagac aggaagtttt aagctcaaaa
     3001 aatttgatga agatggaaaa acacccatta aggatgtaac gtttcagtta acatcggaga
     3061 ccaatccgtc aaactataag attgaacaaa taactagtgg tgcaggtgat gctagcttcg
     3121 ctaatatccc tccaggaact taccttttaa aggaagtggc accgccaagt ggctatcagg
     3181 tgatggctga ttactatagg ataaccgtca gtccagacgg gtacacacaa tatacttatg
     3241 tcaaagtagg gacaacgact agtagtccga caacctctct tccttcgaca agtggtggtg
     3301 gaacaggcgg gacagtcttt aggacgtcaa aaacctctgg cgtagtgaca gtaactgact
     3361 ataactttac aactaaaaat aaagcacaag gaaatacaga ttatacaaca ttatgggcga
     3421 catcgggaga gtttttcgat atgtccttta aattgaaggt caacgaagga acacaagcgg
     3481 gtgattcttt taccataaag ctaagcgact acttatctcc aaatggtatt cgtgaaaaat
     3541 tcatctcggc acctcctttg atgctcgata agaaagtggt tgccacaggg atttatgatg
     3601 agtccaccaa tagctacatc tataccttta atgatctcat taatcataaa caaaacgctg
     3661 aaataacagt caattacacc ttcagtccag aagccaaaaa agttgataga gactggtatg
     3721 taaataccta caatattaca aatatcattg acggtcagaa gcaagattct ggtaacttta
     3781 cgatcgacta tggtcaaggt cagtatatga cagggacatt aaatagtggc ttaaggttaa
     3841 ggaataacat tacttacctt aatcggacaa ctggcgaagt tgaatatacc atttacttaa
     3901 ataatggagc atcacctaga gataaagatt ttactgtaaa aaaccctgta acaggtcgtc
     3961 attttctaaa cttagaggat aaatcagcca gtgttgcatt tacccaaaaa aacataactg
     4021 tctatagggt tcctttaagt caaaaaacaa gcaagatgcc ctacagtatg tcgggggaga
     4081 cagatggact agaatcaata ccatttgact acagcagtaa gggcattacc tttactaaag
     4141 aatcgttcca tgataacgaa actaatagta ataccgcagg attattaata aaaataaaag
     4201 catatataac agctgacaat aaacgatcag cagatgtttc tcttagtgca ggatggactt
     4261 atactaattt aattaggtct aggtcagatg ccaaagccag tgcttttgag ttaggaaaca
     4321 catcatctgg ggtggccaat aatattgagc ctactgtgac cattcgtaac tataaaataa
     4381 aaaaaggttc aatcgtcttt acaaagcaag atgttgaaac caagatgact ttgagtggtg
     4441 ttgcctttag attagagaaa aaagaagaaa atgactggca aattgtcgag aaatacaagg
     4501 atgtccagac cggaacagaa ggcaagttaa tcctgtcaga cttagatcca ggagaatatc
     4561 aattaattga aacaaaacct ttagatgggt atttagtttc atcagggcct gttgtgactt
     4621 ttaccataac agatcaggga acagaaggca cagttaagcc atcggataaa atcatcccga
     4681 acacgaagcc agggaaacaa aagattaaag tcatcaaaaa ggatgagcaa agcagggtac
     4741 cattagccgg agccaagttt cagcttgagt ccaataaggg tgtggtacta actggtgaga
     4801 cagatggtaa gggagagtat acctttacaa acttaccatt tggtgactac attttgacag
     4861 agattgccgc gccaaaagga tacattttgg ataaaacacc tcgctctatt gcaataggag
     4921 atacagtgga taaagagcca gaacctacgg ttgtggaagc tgctacccca aggacagtcc
     4981 gatcagtgag tccttcagca acagtgtccg acaaagatgt gtccagaaat attctagtca
     5041 aaaaagttga atttactaca acaaatggcc aaactccctt acaagttaaa cctaatcaag
     5101 gtgaaaacct gattgctcga tcagaatttg aacttaagaa agagattgat attaagaagg
     5161 gagattattt tgcggttaaa ctctcagata atatagatcc ctttggggtt tcaacaggag
     5221 aaacaacaac ctttaacatc actggtcctt atggtacctt agctgttggt aagtatgata
     5281 gcaagagccg aagtattatt tataccttca cagactatgt tgaaaaatat gaggtttcaa
     5341 atttttcaac gatcttacca tactttatag atcgttatgc tgttactaga gatgctgata
     5401 ttaatatctc aacaagcgtt gggagtcaga caaatactgc aagggttaga gtactataca
     5461 cgccttacta tggagctaca gatagttact ctccagtaaa cattggatca atgataacaa
     5521 aattagatga aaaaaatgga acttttacaa attatattta cattaatcca atgcagcaat
     5581 ttatccgaaa tggtaaatta acattccagg gaggagggtc agctattatt gacaatgaaa
     5641 cgcaggtgac tctgttcaaa gttaataata gtacggatat gcctccaagt tgggggataa
     5701 ctgattcaac cttaagagta gaaaatgata tattggttaa taagaaacaa ggggaaatat
     5761 ctgtagattt tgaaaatatt ttagaggcac gtaattcatt tattatgaaa gtagttggaa
     5821 aaatcgcttc ctcaggcaca tccgtaagga caagcgcaac attatcacag aaatacgata
     5881 acacttacgg ctattattca acaaatggac gctggattcc caagggtccg tattcggaat
     5941 attatagata tgatactaca gctattttac actcagggga tagtaacgtc gacggagcca
     6001 ttaggatatc agtgactaat cgtaaaaata gtgtagcatt tactaaaaca aatggtctgg
     6061 aaaaaccatt ggaagctacc tttgagttac gccgattgaa ttctaataag acttttactt
     6121 ctgtgaaaac aacaaagtca actaaagata cgggtaaatt tagctttgaa ggcatggaat
     6181 ctggaagcta tgaggtttgg gaaacgcagt caccggaagg ttatctgaag ccagataaag
     6241 cagtagctac tttcaaagtt gataaggacg gtacaattaa agatttgaca cctgataacg
     6301 gtaagattat taattatcct aatactgcta agattatttt tacgaaaata ttggcttctg
     6361 aaaaagagga attgtctcct gccacgaaag agaagtctgc aacgttcagt ttatggcgac
     6421 ttaaagagga gagtttgaaa gaaactaata cagtaagtca agcttatgat gagcagtatt
     6481 atgagccagt tatggagaac aatagtgttc ggacagtaac ctcagatagt agtggaaatg
     6541 ttttatttga taagctttct ccgggttttt acgctattaa ggaagaaaag gcgcctgatg
     6601 gctacgttaa gcagcaagga attgtgcgta tcttccaagt agatagttct ggtaaggtaa
     6661 ttaagtatca gtattttaaa gataagtcaa tagctggtaa gctaacagaa attacagatt
     6721 tagaaaccga acagctaaaa caatttaatg agattattaa taaaaagttt gttttcccta
     6781 tgacaggtgg gcagggtatt gcactattaa tgataattgg tggtactatg atgggtattg
     6841 cttattttgg tcatcgtaga aaacaaagat taaatgattg atggttgcta tttgaatatt
     6901 gtggaaaccc tcctttgaga gagggagttg ccagtaattt aacaatcaaa agagtcaaaa
     6961 aaacatttag ataaatattt tttacaaata ggagagaaca gttgaaaacg aagatattta
     7021 gtagattggc agcagtatta ctggttttgg gaagcctttt accgacagtt gtagctgtgg
     7081 cagaagcaga atcatcacat aaaaccgatg ttgttattca taaaatcaaa atgacgagct
     7141 taaaaggctg gccaaaagaa aaaaatccgg atgggactta tacaggactt ggtgataaga
     7201 attataatgg tgaaaaaatt gatacaataa cgagttattt tggtgaaggt gctgaggaac
     7261 ttgatggtgt tagttttact tactggagtg tagacaaaga aaagtataag aagttaacta
     7321 aaaatcctca aaactacgat acggtaccaa aaatgaaagc attcttacaa ggtactgaga
     7381 aaaataaagc tctagagaac tcttcggaaa ctattgacgg gaagaccact ggtcatactg
     7441 ctgataaagg tggcgtcaaa gttaaggatc ttgcagatgg ttactattgg tttgtcgaaa
     7501 attcgggttc caatattgcg aatggagaga ccttgtcttc tagtgcggct gttccatttg
     7561 gattggagtt acctgtttat aaggctgatg gatcaactat aacagagtta catgtatatc
     7621 ctaagaatac cacaacgaag cctaaaattg ataagaattt tagtaaagat gaaaaagatg
     7681 cagcactagc aggtggagct aattatgatt attatcaaaa ggataagggt tatgtttcac
     7741 gtataattgg ttcagaagtt tcttatcaaa ttaaaacaga gattccagct ggtgcacagt
     7801 atcagaccct tcgatgggaa gacacgatga ctaaaggttt gacttataaa gctgggagtt
     7861 tagagctaac tatcacaaca aagggtgatg ggaaagctgc cctgaacttt gagtttcaaa
     7921 cagattataa actaacagaa aatcaaagtg gatttgtctt gaaattcact gaatcgggtc
     7981 tagaaaaagt taaaaaagct gttcaagcaa ctaaggacgc taagggtcaa gttacagctg
     8041 atggtcaccc aatgacagtg gatataagct ataaagcgac tgtcaatagc gatgccgtcg
     8101 ttgaccaacc agacaagaat acagttatct ttgattacag caacaatcct aaagaacata
     8161 aagacccaag agaaaagtct acaaaaccga aagataaaca aatcactgtt gaaaaaacat
     8221 gggctagtca atcagcacca acaggtattg cagtgaccta ctacctttac caaaaaggtg
     8281 atgagtctgg taaggataag gtggtggatt cagtcacatt gactacagat tataagcaca
     8341 tctttacaaa cttagatgac tccaaggact actatgtaaa agaaagtgcc attggttaca
     8401 caccagagta cactgaagct aaagatggaa aaatttccat caagaacacc aaagatgata
     8461 aaaatccaga tcctcttaaa ccaactagtc cagcaattgt aacacatggt aaaaaattcg
     8521 ttaaaactag tcaagacgac gaacgtctaa aaggagccac ctttgttgta gtagatcaaa
     8581 aaactaatga gaaatactta gccattaaag ccgatgaaaa gcagtctgct gaagaaaaag
     8641 cataccacga cacagagcaa aaatatcaag acgaagtcaa aaaagctact acagaaaaac
     8701 ctaattctca agcaattgaa aaagctaaaa aagcgcgtga cgatgccttc aaaaaagcaa
     8761 gaactgctta tgaatgggta agtgataaac aaaaagcagt caaattcacg tcaaatagta
     8821 aaggacagtt tgaggtaaca gggcttgcag ctggaaccta ttacttagaa gaggtagcag
     8881 ctcctactgg ctttgcaaaa cttcaagaaa aggttgagtt tacacttggt ttcaactctt
     8941 acaatgggca taaagatcaa tctggtcaaa gtttggaagg gcatactcaa tatgaaaaag
     9001 gaacacctga ttttggttac ggacaacggg tgattaacaa aaaaatcacc attcctcaaa
     9061 ctggtggtat tggtacagtt atctttactg tggttggttt ggcaatcatg accgttactg
     9121 gattgatgat gatccgtcgt aataaaaatg ataaatcgga atagtttgtt agaaaaatgg
     9181 gaggtacaca attgaaaata ggacgattga ttcgcttgat gctatcgatt tgcgcttgtt
     9241 tgtacttttt gacgtctcct atttttgctt tgcagaaaac gtcatccgtg acgattcatt
     9301 ttgagaattc tgataaggat acacaactag cgttgtggca attgcccgag ggacaaactt
     9361 tgcccgaact ggaaacacta tttgagaaga cagatgctga gttaacccgt cagtatcctc
     9421 aagtatcaac tgtcacagta ccaaaaggtg agactaagct tgtattatca aatctacctg
     9481 taggagcgat ttactacgtt agagaggcag aagaacgctt aggagttcgc tcgctagcgc
     9541 cctttatctt gaaggttgat acagatgatg atcaggccgt ttatacaaag aaagcaaagg
     9601 cccaaaaacg tggttcgtac ccttttgtta aagtttctgc tcaaggtggt agtctagaag
     9661 gagcaacttt tgaggtttgg aaacaaaccc aaaaacagct acaacctgtt attaaaggta
     9721 gcagtcggta tctcctaacg tcctcgaaag atggttcttt tatggcaaga gatttgccat
     9781 ttgggtctta tgttttaaaa gaaatcactg ctccaaaagg ttatcttttg tcaaaaaaaa
     9841 ctataccatt tgaagtaaca gattattcag aaaaacaagc ccctgtgaaa gtcgtcaacc
     9901 agcccaagat ccctcctaga attgaaattc cctatacagg taatgcgatt atgattttgg
     9961 tggttttact tggttttgca ctatttacac taggtgtcta tctggtacgt aggaacggtt
    10021 aacgaagaga caaggcacta agattactag aggtcccgta aggtgcctct agttttttaa
    10081 ataaaaggaa taaaggtgat agcatgaaaa agcaatccaa acggcatcgt ttaaatcaaa
    10141 atattgctct gatagtagtg tttttgatag gcttgactat tttattatac ccacaaattt
    10201 ctaggatata ctacactatt gaatcaaact accagtctaa gcaatttgac cgggagaaat
    10261 caacgttgca tcaagaagat attagtcaga ggatagctct tgcaaaggca tttaatgcca
    10321 gtttgcatga tgtagacctc aaagatccct attccgatga tgaaaaaaca aaaggtcgtg
    10381 cggagtatgc acggatgctt gaacttcatg aacaaatagg acatgtagaa atccctaaga
    10441 taagggtcga tttgccaatt tatgctggaa caagtgatga aattatttct aaagggagtg
    10501 gacatctaga gggaacatct ttgccagttg gtggggaaaa cacgcatacg gtactgacgt
    10561 cacattcagg tttgccctct gcgaaactct tttcagattt agcgaagctt aagaagggag
    10621 atatttttta tatccataac attaaagaaa ttcttgctta ccaaatagat cagattaaaa
    10681 taattgaacc agataatttt tcagatttac tgattgttcc cggtaaagat tacgctacgc
    10741 ttctaacatg taccccagtt gggattaata cgcatcggtt gattgttcgt gggcatcgtg
    10801 ttccatacgt ttctaatgag cacaagaata ataaacaaaa agcgtcatca ggctacatgt
    10861 gctacctgtt tgtacttctt gctttactta cactactttt cggttattgg ttttaccgtc
    10921 agaaaaaaaa gaagagccag aaagttaaga gagaggagtt tcatgctaaa gaataagcaa
    10981 tcattatcgt taagggaacg actaattcaa gtcatgttcc ccttgttatt ccttatggga
    11041 tgtcttatag tgttgtatcc cttgatgtca aactattatt atcgtgtgaa gcaaaaccaa
    11101 gcagtaacgt catttgaatc agctaaagtc atcgttaata aagatgatat caaacgacgt
    11161 atggctctag ctagagccta caatgccact ttagatccag gaaggattaa tgatccttat
    11221 acagatttgg aaaaaaaggg tgttgcggag tacgcgagaa tgctagagct taatgagcaa
    11281 attggttatg ttgaagtgcc gcgttttgat attaatctcc cgatttacgc tggaacaagt
    11341 gacgacgttc tccaaaaagc cgcagggcac ctagaaggaa cctctttacc aattgggggc
    11401 gatagcaccc ataccgttat tacagcgcat actggactac ctcaagctaa attgttcacg
    11461 aatattcaca agatgaaaaa gggagattta ttttttattc ataatattga caagactctt
    11521 gcttacaaag tagaccagat tttagttgta gaacccgata atttcacccc agttttagtg
    11581 aaaaatggtt ttgattatgc aacattacta acctgtacac catacggaat caatagtcat
    11641 cgattattag tacgcggcta ccgtgttcct tatcaaaaag cgtttgaaaa agctgatgct
    11701 caaagaccat ggtatacaaa agttattttt cttgtaagtt ttctactatt tgttatatta
    11761 gtgataattc ttttaatcga ttggcatcgc aagtaataca gaaaggaata gtttagtgtc
    11821 taaacaaaaa tgtgttggct atgttttaat gattttggga cttggtcttc ccttattttt
    11881 cttaacacta atgtccctta accaatttca agagcaggtt gcttatcaaa agtttcaaac
    11941 ggagaataga tcgtggaaaa attcacaaaa agaatgggtt aatcgtcaca atcaagagca
    12001 agcgttagcc gacagagcca caacagaccc gtttgtagat gcacaaaacc agttgaagca
    12061 gagccctttt gacgataata ttattggtta tattatcatt ccaaagcttc gcatggcaca
    12121 accgattcgt gtaggtgcaa gtgaacgtca tcttgaaaag ggagtagcgc aggttactgg
    12181 aactagccta cccatcggcg gattagggac gcgatcggtt attgcagggc accgtagctg
    12241 gtatgataat gaacgttttc ttaggatagc agaattatct cttggagatc agattgtgat
    12301 tgatttaggt gtttatcaat tagagtatcg tgttaagagt gttgagatta ttgatgccaa
    12361 agattggcgc caattaacgg ctaaaaaaag ccaagattta ataacgttac ttacctgtaa
    12421 tcctctttat ccccctttta atgaaaggct actagtaaat gcagagagag tgttgcctag
    12481 cctttctgat ttaccaacta aaacgcgaaa taagatggat caatctcaac tagaaagtcc
    12541 actggcgtct cacaagactt cacttgtcaa attaccgcta gtattacctt ttgggatttg
    12601 ggtctgtttg ggctggttga tagaaagtta tttcatatac cgtctatttc gccaatgcaa
    12661 aggtgatagc taatacttct gacgacgttc cctcccctct cattagttta ggtaatatta
    12721 gttactgcat cgtttacgtt gagccataac ctattacaag cagattaaag gggtgaaaat
    12781 gagtctatga caaaagctta gtagtttggt catatcatta actacaagag accagagctg
    12841 cttgttaagt agttcaaaaa ggcagagcct taaaagattt tctgcctttt taatcttgtt
    12901 gggcacttac gaaagtattt cggccacttc aagcataata aaaagagtct gagcaatcat
    12961 gttgtctcag actctgactg tattatgcaa aagatgatgg actggcagct tcatttactc
    13021 accgaactcc cctttataac ttgggaatga tgctgctaat gggttgtttt gtttaatacc
    13081 tgctataaac ggtaatttat tccatttatc tttgtaatta tcttcaagct cagttttaaa
    13141 cttccaaacc attttatgag aaaaataagt gtgtgattga cggccatagg tgtctactaa
    13201 aacgtgagaa aattttcctt cgttttttag tttgtaaaat ttatctagag aacgactcca
    13261 gccagtataa ccagggaatt tatcaaattc ttgattaaaa tttgtttttt gtttttccca
    13321 atcataatgc cattgtgtat tactgcgttt tttagaatca actgtaccgt tcccataatg
    13381 atgctcataa gttatctcct taggagcttt tacaccctta ggaagaaaaa ctgagaaatc
    13441 agggtaaacc cattgttctt tagctgaatt aaaggttaca gtccattcga tactgttatt
    13501 gaccaatttt ttagtatagt cgacatagtt atcaacatag taatttccct gccagtaaag
    13561 gtgcacttta ccttcctcat caatgttgtc atgggcatgt actgatttat acgaactaaa
    13621 cagcatcgaa gctgctagta gtgaggtgaa gagatattta ttacatcgtt tcatatcatg
    13681 aaaaacc
//
LOCUS       DAUDWO010000047        13280 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.048, whole genome shotgun sequence.
ACCESSION   DAUDWO010000047 DAUDWO010000000
VERSION     DAUDWO010000047.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13280)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13280)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13280
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.048"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(<1..1476)
                     /locus_tag="VHC05_001516"
     CDS             complement(<1..1476)
                     /locus_tag="VHC05_001516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011185060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2079 domain-containing protein"
                     /protein_id="HEQ5402808.1"
                     /translation="MIELNDEFIRKETIELANDGPRVHTTQYETKVPRLHKCYLLFFS
                     IIISSLTIAVPFLTDAANGLQSQNLYIGMMLTKGQLPYSDAFTTGGLFYFVIIALSYY
                     LGSTLWLVFVQVFCFYLSGLYLYKLINYMTGFQKVALTFSISYYLLSVSLGFGGLYPT
                     QLAMPFILISAWFLTKYFACLVKDEAFILFGFVGALAMLIDPSTLIFWSFACVTVFSY
                     NISQKHLARGFYQLLASIFGMILVFYTAGYFILNLQVLNPYLSQTMIYPFTFFKSGNL
                     SLLFGLAIQLFFALGLGLLTGMENVIRRFKNNSDRVVKWLFVMVILESILVAIFSQDY
                     RPYHLLPLLPFGLILTAIPVGYQYGIGLGQSSHRRRHGKNGVGRVMMIYLKRHFYLPI
                     LIVGTILICSTYCFISSIPLNQERDHIASYLEQKLNKTQSIYVWDDTSKIYLDSKAKS
                     VSQFSSPDINTQKESHRKILEDELLENKAAYIVVNRYKNLPK"
     gene            complement(1890..2195)
                     /locus_tag="VHC05_001517"
     CDS             complement(1890..2195)
                     /locus_tag="VHC05_001517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1292 domain-containing protein"
                     /protein_id="HEQ5402809.1"
                     /translation="MTHNHENDHQHEVITLVDEQGNETLFEILLTIDGREEFGKNYVL
                     LVPAGSEEDESGEIEIQAYSFTENEDGTEGDLQPIPEDSDAEWDMIEEVFNSFLDEN"
     gene            complement(2207..2626)
                     /gene="ruvX"
                     /locus_tag="VHC05_001518"
     CDS             complement(2207..2626)
                     /gene="ruvX"
                     /locus_tag="VHC05_001518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="HEQ5402810.1"
                     /translation="MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIKIDEEKAEFGFTR
                     LEELVKQYQVEQFVIGLPKNMNNTNGPRVDASITYGNHIEHLFGLPVHYQDERLTTVE
                     AERMLIEQADISRGKRKKVIDKLAAQLILQNYLNRNF"
     gene            complement(2623..2892)
                     /locus_tag="VHC05_001519"
     CDS             complement(2623..2892)
                     /locus_tag="VHC05_001519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IreB family regulatory phosphoprotein"
                     /protein_id="HEQ5402811.1"
                     /translation="MGFTDETVRFKLDDGDKRQISETLTAVYHSLDEKGYNPINQIVG
                     YVLSGDPAYVPRYNDARNQIRKYERDEIVEELVRYYLQGNGIDVK"
     gene            complement(3006..3404)
                     /gene="spx"
                     /locus_tag="VHC05_001520"
     CDS             complement(3006..3404)
                     /gene="spx"
                     /locus_tag="VHC05_001520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768833.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator Spx"
                     /protein_id="HEQ5402812.1"
                     /translation="MIKIYTISSCTSCKKAKTWLNAHKLAYKEQNLGKEPLTKEEILA
                     ILSKTENGVESIVSSKNRYAKALDCDIEELSVSEVIDLIQDNPRILKSPILIDDKRLQ
                     VGYKEDDIRAFLPRSIRNIENTEARLRAAL"
     gene            complement(3695..4831)
                     /gene="recA"
                     /locus_tag="VHC05_001521"
     CDS             complement(3695..4831)
                     /gene="recA"
                     /locus_tag="VHC05_001521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015912068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecA"
                     /protein_id="HEQ5402813.1"
                     /translation="MAKKLKKNEEITKKFGDERRKALDDALKNIEKDFGKGAVMRLGE
                     RAEQKVQVMSSGSLALDIALGAGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGI
                     AAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVA
                     ALVPRAEIDGDIGDSHVGLQARMMSQAMRKLSASINKTKTIAIFINQLREKVGVMFGN
                     PETTPGGRALKFYASVRLDVRGTTQIKGTGDQKDSSIGKETKIKVVKNKVAPPFKVAE
                     VEIMYGEGISRTGELVKIASDLDIIQKAGAWFSYNGEKIGQGSENAKRYLADHPQLFD
                     EIDRKVRVKFGLLEESEEESAMAVASEETDDLALDLDNGIEIED"
     gene            complement(4920..6191)
                     /locus_tag="VHC05_001522"
     CDS             complement(4920..6191)
                     /locus_tag="VHC05_001522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence/damage-inducible protein A"
                     /protein_id="HEQ5402814.1"
                     /translation="MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGD
                     NEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQTLAKYLRRDLVYDEQACQKLDDF
                     FAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPI
                     VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTL
                     RLSTKTENQALADKKLGQLEAQLLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKY
                     DKSITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKMLGLPLEELKSHGVV
                     SAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLI
                     SGRSRLDVCYIATLHAFNMVRKTLLKLENLL"
     gene            complement(6260..6820)
                     /locus_tag="VHC05_001523"
     CDS             complement(6260..6820)
                     /locus_tag="VHC05_001523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-3-methyladenine glycosylase I"
                     /protein_id="HEQ5402815.1"
                     /translation="MKRCSWVPKDNQLYCDYHDLEWGQPLHDDRDFFELLCLESYQSG
                     LSWLTVLKKRQAFRTVFHHYDIASVATFTSEELADALENPSIIRHKLKLAATVNNAIA
                     VQKIQEEFGSFSTYLWNFVGGKPINNLVNQENLVPAQTELSIRLAKDLKKRGFKFLGP
                     TTVYSFMQASGLVNDHEEACVFNRIF"
     gene            complement(6830..7426)
                     /gene="ruvA"
                     /locus_tag="VHC05_001524"
     CDS             complement(6830..7426)
                     /gene="ruvA"
                     /locus_tag="VHC05_001524"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015912071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="HEQ5402816.1"
                     /translation="MYDYIKGQLTKITAKYIVVEANGLGYMINVANPYSFTDSVNQLV
                     TIYLHQVIREDAHLLFGFHTEDEKDVFLKLISVSGIGPTTALAIVAVDDNEGLVNAID
                     NSDIKYLMKFPKIGKKTAQQMVLDLAGKFVEAPQETGHTKARSNKAGNTQLDEAIEAL
                     LALGYKAKELKKIRAFFEGTSETAEQYIKSALKLLMKG"
     gene            complement(7428..8648)
                     /locus_tag="VHC05_001525"
     CDS             complement(7428..8648)
                     /locus_tag="VHC05_001525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEQ5402817.1"
                     /translation="MQEFLNLPKQIQLRQLVRFVTITLGSSIFPFMAMYYTTYFGTFW
                     TGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFSTILANLPNAAIPW
                     LTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLF
                     YDHHFLALLVALLLVNVLCFGVAYYYFDETRPETHAFDHGKGLLDSFRNYRQVFHDRA
                     FVLFTLGAIFSGSIWMQMDNYVPVHLKLYFQPTAVLGFQVTSSKMLSLMVLTNTLLIV
                     LFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVP
                     ASQVLRADMMDHSQIGSYTGFVSMAQPLGAILASLLVSVSHFTGPLGVQCLFVVIALL
                     GIYFTVVSAKMKKV"
     gene            complement(8659..10641)
                     /gene="mutL"
                     /locus_tag="VHC05_001526"
     CDS             complement(8659..10641)
                     /gene="mutL"
                     /locus_tag="VHC05_001526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HEQ5402818.1"
                     /translation="MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQIT
                     VEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSKIKSQSDLFRIRTLGFRGEALPS
                     VASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
                     MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTT
                     KKMLAISNADLDFEVSGYVSLPELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKL
                     MVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALISTAISESLKEQDLIPD
                     ALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAV
                     DNSVKVEKAELLPHSEEVIGPSSVKHASRPQNIFTETDHPNLDLKNRQKLSQMLTRLE
                     NEEKSVFPELDYFGQMHGTYLFAQGKDGLFIIDQHAAQERVKYEYYRDKIGEVDSSLQ
                     QLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEEEIASGV
                     YEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYN
                     CPHGRPVLINFSKADMEKMFRRIQENHTSLRELGKY"
     gene            complement(10736..11881)
                     /locus_tag="VHC05_001527"
     CDS             complement(10736..11881)
                     /locus_tag="VHC05_001527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEQ5402819.1"
                     /translation="MKITEHKKKNGTIVYRASIYLGIDQMTGKRVKTSITGRTRKEVN
                     QKAKHAQLDFLSNGSTIKRKVVIKTFKELSHLWLETYKLTVKPQTYDATVTRLNRHIM
                     PTLGNMKVDKITASDIQMLINRLSKYYVNYTAVRSVIRKVLQQGVLLGLIDYNSARDI
                     ILPRKQPNAKKKVKFIDPSDLKSFLEHLETSQHKRYNLYFDAVLYQLLLSTGLRIGEA
                     CALEWGDIDLENGTIAINKTYNKNLKFLSTAKTQSGNRVISVDKKTLRSLKLYQMRQR
                     QLFNEVGARVSEVVFATPTRKYFNASVRQSALDTRCKEAGIERFTFHAFRHTHASLLL
                     NAGISYKELQYRLGHANISMTLDTYGHLSKDKEKEAVLYYEKAMNNL"
     gene            12084..12227
                     /locus_tag="VHC05_001528"
     CDS             12084..12227
                     /locus_tag="VHC05_001528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011185066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative holin-like toxin"
                     /protein_id="HEQ5402820.1"
                     /translation="MSGGGAYVCKSQKPKERRRQGLSVYETLTLMIAFGTLIVAIMNN
                     KNK"
BASE COUNT         4211 a         2712 c         2206 g         4151 t
ORIGIN      
        1 tttaggcagg tttttatagc gattaacaac gatataagca gccttatttt ctaatagttc
       61 atcttctaat atttttcgat gactctcttt ttgcgtattg atgtcaggag aactaaattg
      121 agaaacagat ttagctttac tgtccaaata aattttagaa gtatcatccc aaacataaat
      181 agattgagtt ttatttagtt tctgttctaa ataactagca atatgatcac gctcctgatt
      241 aagaggaata ctactaatga aacaataagt agaacagatt agtattgtcc ctacaattaa
      301 aattggcaaa taaaagtgtc tcttaagata aatcatcatt actcgaccaa caccattttt
      361 accatgacgt ctgcgatgac tactctgacc taatcctata ccatactgat agccaacagg
      421 aatagcagtc aaaattaatc caaaaggtaa aagaggtaaa agatgatagg ggcgatagtc
      481 ttgtgaaaat atagccacaa gtatagattc tagaatgacc atgacaaata gccacttgac
      541 gaccctatca gaattgtttt taaatcgcct aatgacattc tccattcccg tcaaaagacc
      601 aagccccaaa gcgaagaaca actgaatagc cagtccaaaa agcaacgata agtttcctga
      661 tttaaaaaaa gtaaaaggat aaatcatcgt ttgtgataaa taaggattta gcacttgtaa
      721 gttcaaaatg aaatatcctg ctgtgtaaaa aactaaaatc attccaaaaa tcgaagctag
      781 cagttgataa aaacctcttg caagatgctt ttggcttata ttataagaaa aaactgtcac
      841 acaagcaaaa gaccaaaaga taagggtact cgggtcaatt agcattgcaa gagcacctac
      901 aaagccaaaa agaataaatg cctcatcttt cactaaacag gcaaaatact tagttaaaaa
      961 ccaagccgat attaatataa atggcatagc cagttgagta ggatacaatc ccccaaaacc
     1021 aagactaaca gataacaaat agtagctaat tgaaaaagtt aaagccactt tttgaaagcc
     1081 tgtcatataa ttaatgagtt tataaagata taaaccagat aagtaaaaac aaaacacctg
     1141 aacaaagact agccaaagtg tcgatcccaa ataataactt aatgcaatga taacaaagta
     1201 aaagagccct cctgttgtaa aagcatcact atagggaagt tgccccttcg ttaacatcat
     1261 tcctatatat aagttttggg actgaagacc attggctgca tctgttaaaa aaggtactgc
     1321 aattgttaaa gaactgataa taatgctaaa gaaaagcaga tagcatttat gaagccgagg
     1381 tactttagtt tcatattgag tggtgtgtac tcgtgggcca tcgttggcca gttctatcgt
     1441 ctcttttcgg atgaattcat cgtttaactc gatcactatt tttctccttg aaatatcata
     1501 ttctctaacg attcaataaa agcaatattt cttcatatca ctagtctaac atagctatta
     1561 tccattattt tttagtatga gataaataac atgactttgt attgcacata gcaaagtgac
     1621 agtgcataaa caaagtaagt tgaaaaatga tattatcgtc aaagaatatt ataaaacaag
     1681 tataacagaa tcttttattt agtcaatttc tgatatattt tcacatactg taataattct
     1741 ctaaatctat gcaaaggttt agccttataa ttattaataa atttatcatt taattctttt
     1801 atcattatca cctcctgctt atttattcga aaataacatt aaaaaaaata gccctcacgg
     1861 ctacttttta acatagtgtc actaacaatt tagttctcat ctagaaaact attaaatacc
     1921 tcttcaatca tatcccattc agcatctgaa tcctcaggaa tcggttgtaa atccccttca
     1981 gtaccatctt cattttcagt aaatgaatag gcttggattt cgatttcacc agactcatct
     2041 tcttcagatc ccgctggaac caagagaaca taatttttac caaactcttc acgaccatca
     2101 attgttaata aaatttcaaa caaggtttca tttccttgtt catccacaag tgtgataact
     2161 tcgtgttggt ggtcattttc atgattatgt gtcatttttt atctccttaa aaattccgat
     2221 ttaaatagtt ctgtaaaatg agttgtgcag ctaatttatc aatgactttt tttcgcttac
     2281 cacgactaat gtcagcttgc tcaataagca tacgctctgc ctcaacagtc gtcaatcgtt
     2341 catcttgata atggactgga agtccaaaaa ggtgctctat gtggtttcca taagttatac
     2401 ttgcatcaac acgtggacca ttggtgttat tcatattttt tggcaatcca ataacaaact
     2461 gttcaacttg gtactgctta acaagctctt ctaaacgtgt aaagccaaat tctgcttttt
     2521 cctcatcaat cttgataatt tcaagtcctt gggctgtaaa gccaagagga tcactaatag
     2581 ctacgccaac cgttttcgag ccaacatcaa gtcccattat tctcatttaa catcaattcc
     2641 atttccttgt aaatagtagc gaacaagttc ttctacaatt tcatcacgtt catatttacg
     2701 aatctgattt cgagcatcat tataacgagg aacataagct gggtccccac tcaagacata
     2761 accaacaatt tgattaattg gattataacc tttttcatca agtgaatgat agactgctgt
     2821 taatgtttca ctaatttgtc gtttgtcacc atcatccaac ttaaagcgga ctgtttcatc
     2881 tgtaaatccc atacttacac cttctttcta aaattaagtg ctatgcttta ttatagctta
     2941 tttctattaa ataaacaaga atttcaagcg aagaaggtat ttaaaaaaaa gctctacaag
     3001 agcttttaga gtgcagcacg taatcgtgct tcagtatttt caatattacg aatagagcga
     3061 ggtaaaaaag cacgaatatc gtcttctttg tagcctactt gcagacgttt atcatcaatc
     3121 aaaatgggac ttttaaggat gcgcgggtta tcttgaatca aatcaataac ctcactaaca
     3181 cttaattctt caatatcgca atcgagagct ttggcataac gatttttaga tgaaacaatg
     3241 ctctccactc cattttcggt ttttgataaa attgctaaaa tttcttcttt agttagcggt
     3301 tcttttccta agttctgttc tttataagca agcttatggg catttagcca agttttggct
     3361 ttcttgcagc tcgtacaact tgaaatcgtg taaattttaa tcatgttgct gactcacttt
     3421 ctatttcgtg atagctttat tgtagcacag tttcttatct ataaatatag gtctttggac
     3481 ctattttttt aattttaaag atattatctt ggtaaaataa ggtttttcac ctgtattccc
     3541 ttgaattatt agttatttta attttatatc agttaaccta agttctgctc tctcacatct
     3601 ttttaaatga tagtttcttt tcacccacac acctatgaac agtagtccta ctaaccttta
     3661 aaaatacatt ttaaaaagcc ctgaagggct ctttttaatc ttcaatttca ataccattat
     3721 ctaaatctaa agcaagatca tcggtttctt ctgatgctac tgccatagca gattcttctt
     3781 cgctttcttc aagcaaacca aatttaacac gtactttacg gtcgatttca tcaaacaatt
     3841 gtggatgatc ggccaaataa cgcttagcat tttcagaacc ttggccaatc ttctcaccat
     3901 tataagagaa ccaagcacct gctttttgga taatgtccaa atcagaagca attttcacaa
     3961 gctcccctgt acgagaaata ccttccccat acatgatttc aacttctgct accttaaatg
     4021 gcggagcgac cttgttttta acaaccttga ttttggtctc cttaccaatg ctgctatcct
     4081 tttggtcacc agttccttta atttgagttg ttccacgcac atccagccga acagaagcat
     4141 agaatttcaa agctcgacca cctggtgttg tttcaggatt tccaaacatc acaccaactt
     4201 tttcacgcaa ttggttaata aaaatagcga tagtttttgt tttattaata gaagctgata
     4261 atttacgcat ggcctgactc atcatacgtg cttgcaatcc gacatggcta tcgccaatat
     4321 caccatcaat ttcagcacgt ggcactaaag ctgctactga atcgacaaca accagatcaa
     4381 ccgcaccaga atcaatcaat ttacctgcaa tttcaagtcc ttgttctcca gaatctggtt
     4441 gagacaagag gagttcatca atattaaccc caagcgcagc agcataagct ggatcaagcg
     4501 catgctcggc atcgataaag gctgcgattc caccttcttt ttgagcttgt gctacagcat
     4561 gtaaagccac agtcgtttta ccggaagact ctggaccata gatttcgatg atacgtcctt
     4621 taggataacc accagctcca agcgcaatat caagagctag acttcctgaa ctcataacct
     4681 gaactttttg ctctgcacgt tctcctaatc gcatcactgc gcccttaccg aaatcttttt
     4741 caatattttt caaagcatca tcaagagctt tgcgacgttc gtcaccaaac ttcttagtga
     4801 tttcttcatt cttttttaat ttttttgcca atactttctc ctctttttta acaaaccatc
     4861 gtcagcagga ttaatctaca taattgtaaa ccatatccta ctatagctac taaataacat
     4921 tatagcaaat tctcaagttt taataaagtt ttacggacca tattaaaggc atgtaaagta
     4981 gcgatatagc acacatccaa acgacttcgc ccgctaatca aaacctttat tgattctacc
     5041 ttattttgag tggcaagacc aatgaaaact gtacctgcag gctgttcctc caacatatct
     5101 ggtccggcaa cacctgttaa acttacccca atatcagcac cagtcaataa ccttgcttgc
     5161 tccgccatcc cctcggccgt ataagcacta acaacgccat gcgatttcaa ctcctctaaa
     5221 ggaaggccta gcattttcgc tttttcttcc atgctataag tcacaaagcc tccattgaat
     5281 acttgagaag ctcctggaaa actcgccaaa gttgactgaa ataatcccgc ggttagactt
     5341 tctgctgctg taattgactt atcatatttt actaagagct caaatgtctc acgcgctaag
     5401 gaattatcct ccccatagcc ataaaagaca tcagctaagg gttgaccttc aagagttttt
     5461 cgggatagta gctgcgcttc tagctgacct aactttttat ctgccagagc ttggttttca
     5521 gtttttgttg ataagcgaag agtcacttcg ccagtcttag catacggagc aatggttgga
     5581 tcagtttgat tctcaataaa atctgacaag actgttacca actgactttc cccaatacca
     5641 aaaaagcgta gtacctttga atacaatgta ctgtattgtt ttgacagaag tggtaccaat
     5701 tcttcattta ctatcggctt caattcactt ggaggacccg gtaagacaac ataactaata
     5761 ccatcgactg taatgaaccc accaaccgca agaccagttt tatttggcaa agggattgat
     5821 ccttcaatca cttgtgcctg tcgctcatta tttggtgtcc gtgatgaagg cttgcgctta
     5881 gcaaaaaagt catctagttt ctgacaagct tgctcatcat aaaccaagtc tctcctaagg
     5941 tactttgcta aagtttgttt ggttaaatca tctttcgttg gaccaaggcc accgcataaa
     6001 atgaccaaat cactccgctg actagcagtt gtaatcactg aaagtaaacg ctcctcgttg
     6061 tccccaacag ccgtttgaaa atagacatca atacctagct ctgccatttt ttccgacaga
     6121 aattgagcat tggtattcac aatttgacca gtcaaaattt cggtacctac tgcaatcagt
     6181 tcagctttca tttccccacc tacttatcta ttcgtaatct gatctcattt tatcaaaaaa
     6241 tcttccaatt cacgaagaat tagaagattc tattgaaaac acaagcctct tcatggtcat
     6301 ttaccagacc cgatgcttgc ataaaagaat aaaccgttgt aggccctaaa aatttaaatc
     6361 ctcttttctt taaatcctta gctaagcgaa tagataattc tgtttgagca ggaacaagat
     6421 tctcttgatt gacaaggttg ttaattggct ttcccccaac aaaattccag agataagttg
     6481 aaaaactacc aaactcttct tgaattttct gtactgcgat agcattgttg acagttgctg
     6541 ctagctttag cttgtggcga atgatggatg gattctctaa agcgtcagcc agttcctccg
     6601 aggtaaaggt tgcaaccgat gcaatgtcgt aatgatgaaa aacagttctg aaagcttggc
     6661 gttttttcaa aacagtcagc caggataagc ctgactggta actttcaagg cagagtaatt
     6721 caaaaaaatc tctatcatca tgtaggggtt gaccccattc taaatcgtgg taatcacagt
     6781 aaagctggtt atccttagga acccatgagc aacgtttcat gtgaaacacc taccctttca
     6841 ttaacagttt caatgctgat ttgatgtatt gctctgccgt ctcagaggtc ccctcaaaga
     6901 aggcacgaat ttttttcagc tcttttgctt tataaccgag ggcaaggagg gcttcaatcg
     6961 cttcgtccag ttgagtattg cctgctttat tgctgcgcgc tttggtatga ccagtctctt
     7021 gtggagcctc cacaaatttg ccagctaagt caagaaccat ttgctgcgct gtttttttac
     7081 caattttagg aaatttcatt aggtacttaa tgtcactgtt atcaatggca ttcacaagtc
     7141 cctcattatc atcaactgcc acaatagcaa gagctgttgt cggaccaata cctgatacag
     7201 aaattaattt cagaaaaaca tctttttcat cttccgtgtg aaaaccaaac aacaggtgag
     7261 catcctcacg aatcacttga tgcagataaa tggttaccaa ttggttgaca ctatctgtaa
     7321 agctataagg attggcaaca ttaatcatgt agcccaatcc attagcttca acgacaatgt
     7381 attttgccgt aattttggtc aattgacctt taatataatc gtacatatta cacctttttc
     7441 atttttgcag aaacaaccgt aaaataaatc cctagcaaag caatgactac aaataagcat
     7501 tgcacgccta aaggacctgt aaaatggctg acagatacta ggagactagc caaaatagca
     7561 cctaggggtt gtgccattga cacaaaacct gtataagatc ctatttggga atgatccatc
     7621 atatcagcac gtaggacttg actagcagga acatttatca tttccccaaa agttaacaaa
     7681 acaactgata accagatagc atagaactgc gtaaaggtaa atgccaagag catccctaga
     7741 gtaaatagta aagaaccaac cacaagctga ggtaatagtt tccatttttc cgttaattta
     7801 tttactactg tcatgaaaag gacaatcagc aatgtattag ttaaaaccat taatgataac
     7861 attttagaac tagttacttg gaaacctaac acagccgttg gctgaaaata cagtttcaaa
     7921 tggactggca catagttatc catctgcatc cagatactac cagaaaagat ggcacctaag
     7981 gtaaacaaga caaaggcacg atcatgaaac acctgacgat aatttcgaaa actatccagc
     8041 aagccttttc catgatcaaa agcatgtgtc tctggtctag tctcatcaaa atagtagtaa
     8101 gcaacgccaa aacaaagtac attgacgagt aataaagcta ctaacaaggc taaaaaatga
     8161 tgatcataaa aaagcccaga tagccctgca ccaaacatga cggcaatatt gataaaccaa
     8221 taattgatgg tgtaaacaaa tcgacgatta ctctcatcag tcaaatcaat caacatagct
     8281 tcataggcag gaccataaaa actagaagca atctctacca ataaaatacc cgcaaaggtt
     8341 aaccaaggaa tagccgcatt aggcaaatta gctaaaatag tcgaaaacca gcctagcgtt
     8401 gttcctactg acccaatcat aatgactttt ttgcgaccaa gagcatctga caaatgccca
     8461 ccgtataaag ttccaacaaa tcccatcaaa ctggtaatca tcattaagag gcctgtccaa
     8521 aacgtaccaa agtaagtcgt ataatacatg gccataaagg gaaagatact actgcctaag
     8581 gtaatggtca caaagcgtac cagttgcctc agctgaatct gcttaggaag gtttaaaaac
     8641 tcttgcatct catcctctct aatattttcc tagctctcgc aggctagtgt gattttcttg
     8701 aattcgacgg aacatttttt ccatatctgc cttactaaaa ttaatcaata cgggtctacc
     8761 atgagggcag ttataaggat tttgacattg ggccaattgc agtagcagat ttcttgctga
     8821 ataatcatcc aagctatgat ttgccttgat agatcgttta caactcatca taatagctaa
     8881 ctctgctcgg taagttttaa tagatacctc attggttaga agtaacatgt cacacatttc
     8941 atagacacca gatgcaatct cttcttcttt catccagata ggatgctccc tcaaaatgaa
     9001 agtattgtgc ccataaactt ctaagaagat accaacttca tttaagagtg ccattttctc
     9061 ctgtaagtta atgaaatcag aaccggaaaa ctcaaacaaa tagggcacca acaattgctg
     9121 taaactactg tcaacctcac ctatcttatc acgataatat tcgtatttaa cccgctcctg
     9181 ggcagcgtgt tggtcaatta taaataaacc atcttttccc tgagcaaaga gataagttcc
     9241 gtgcatctga ccaaaataat ccaattcagg aaatactgat ttttcttcat tttccaaacg
     9301 ggttagcatt tgagataact tttgtctgtt ttttaagtca agattaggat gatcagtctc
     9361 ggtaaagata ttctggggac gacttgcgtg tttaaccgaa gaaggtccta taacttcttc
     9421 tgagtggggt aacagctctg ctttttcaac ctttacactg ttgtcaacag cgccggaata
     9481 aaaatcagtt tcaggtattt tttccgagac agccgactct ttgacaaaaa agtcattctt
     9541 ttgaggatca taataaagtc ccctagactg taaaggaagt tgtgtttgct ctggtttaga
     9601 gaaatgtcgt gtgcttgatt tggctaagtt ttccagagca tctggaatca aatcttgttc
     9661 cttaagactt tcagaaatcg ccgtactaat taaagccatc aactcacgct cttttgaaat
     9721 acgaacctct tgttttgtgg gatgaacatt gacatcggcc aaatagggat caatctgaat
     9781 atcaatcaca acaattggga aacgtccaac catgagctta gaaccgtaac catcaagaat
     9841 tgctcgatta agcaagaaat tcttgatgta acgcccatta accaaaatcg tcatgtaatt
     9901 acggttggcg cgtgtcaact ctggcaagct aacatagccg gaaacttcaa aatccaaatc
     9961 agcattagag atagccagca tttttttggt agtatttaaa ccataaatcc ctgcaattgc
    10021 ttggcgtaaa tcgccagttc ctgatgtctg agttaattgg cgaccatcac taatcagtgt
    10081 gaaagcaact tctggatgtg ccaaactcaa ccggttgacc acatctacaa tgtgagctaa
    10141 ttctgcctgt aaacttttca tgtatttgag acgagcaggc gtgttgtaaa aaaggttttc
    10201 aaccttaatt ttggttccag taggagttga gatcgcttca agtgtctcaa tttccccacc
    10261 agtagctata agaagagaac cgtgagtgac ttcttttgtt gctgttttta tcgtgatttt
    10321 actgatagag gcaacagacg gtaaagcctc tccacggaag ccaagtgttc taattctaaa
    10381 caaatcactc tgactcttaa ttttactagt agcgtggcga cgcagactta aaggtaaatc
    10441 ttcatgagac attccctcac cgttgtctgt aacctgtatc atcttaaggc cagactcttc
    10501 aatttcaacg gtaatctggc tacttttagc atcaatagca ttctcaacca attccttgac
    10561 aacactcgct ggcctttcta caacttcacc agctgcaatt tggttggcga gaacttccgg
    10621 taattcaata atgtttgtca taattttgtt tttaacactt tctaaacgtt gatataacaa
    10681 ggtttcatta ggtttacacc tctcaaaata ttaatttgtg gacttttttg tggacttata
    10741 aattattcat agccttttca taatataaaa cagcttcttt ttctttgtcc ttagaaagat
    10801 ggccataggt atccaaagtc atgctgatat tcgcatgtcc tagacggtac tgaagttcct
    10861 tataactaat accagcgttc agcaataaac tagcgtgagt gtgtctaaaa gcgtgaaagg
    10921 taaagcgttc aatccctgct tccttacacc tagtatctaa agcgctttgt ctaaccgaag
    10981 cattaaaata ctttcgtgtt ggtgtggcaa acactacctc cgacacacgc gcaccaacct
    11041 cattaaataa ttgtcgctgt ctcatttgat agagctttag gcttctaagg gtctttttat
    11101 caacactaat cactctattg cctgactggg ttttagctgt actcaaaaac ttcaaatttt
    11161 tattgtaagt cttattaatg gctattgtac cattttctag gtcaatatct ccccactcta
    11221 atgcacaggc ttcgcctatc ctcaagccag tggataataa aagttggtag agaactgcat
    11281 caaagtaaag gttatagcgt ttgtgttgac tagtttctaa atgttctaaa aaagatttca
    11341 aatcagacgg atcaataaac ttaacttttt tcttagcgtt tggctgcttc cttggaagga
    11401 taatatctct tgctgagtta taatctatta accctagcaa tactccttgt tggagaactt
    11461 ttcggatgac tgaacgtacc gcagtataat tgacataata tttagataat ctattaatca
    11521 gcatttgaat atcactagcg gttatcttat caaccttcat attgcccaga gttggcataa
    11581 tatgtcgatt aagtctagta acagtagcat cataagtttg aggctttact gttaacttat
    11641 aggtttcaag ccataaatga ctaagttctt taaatgtttt aatcacaact tttcttttaa
    11701 ttgtagatcc attagatagg aagtcaagct gcgcgtgctt ggctttttga ttaacttctt
    11761 ttcttgttct tcctgtgatg cttgttttta ctctcttacc tgtcatttgg tcaatgccta
    11821 gataaatact agcacgataa acgattgtac catttttctt cttatgttct gttattttca
    11881 tgattataaa cctttccatc agcaggcaag ctattattaa aagggtttta gattagttca
    11941 taccatggta taatattagt ctttttaaga ccttgcgagc gtggaaaact tgcggggtct
    12001 tttttgtttg gttttgtaag gtatagagag tttcagaaga agttttgcat gtctaaaaac
    12061 taggtcaagg tagtcgtagc cttatgtctg gaggtggtgc ttatgtatgt aagtcacaga
    12121 aaccaaaaga aaggagacga caaggtttgt cagtttatga aacgcttact ttgatgattg
    12181 cctttggtac tctgatagta gctatcatga ataacaagaa caaatagaaa aaccgtccca
    12241 cactttagcc aatcgtggac ggtttataga aaatataaac aaatacggta aggctgccgt
    12301 cttaaacggt gctaccacag gagattgttt gcgcaatctc ctttttctat gtccattata
    12361 gctttgtttg ataaagaagt caaagggtat agttagaaag tatagtcttt agcgctctta
    12421 acattcctta gtgttaccaa aatgaataaa aataatttta tgcaagaatt tataatgctt
    12481 tatgcaacca ctgaccacgc gcagacagtt tttttaatta ccgccgacaa aaagttcaga
    12541 aaagttcaga ttatacctca atttttgtca agttttgagg gtcttgtaat taaagaaaat
    12601 taaaggcgta tcaaggtatt tgcgcgtagg taaagataat aaatttggca tttagacatg
    12661 aaaattgaac aggtcataaa atgagcggta acggtaaggt tacagtaagg tagctaattt
    12721 tattccacgc gcacaatgct gaacttcgag cgaacttaga gaatagaagg ttactactcc
    12781 caaacacgaa cacatggtcg catttcggaa tgctggaaaa tgttggcacg tactgacata
    12841 atacgtcaac ctatttcaat agccctaaaa cgctcgggaa attcacttaa agaacttgaa
    12901 aaaacttgat atatcggtcg tttattaatt tattttttcc gttgtgacag cttctaaaat
    12961 cagttggcat ttttagtata tagtattcgg cctccttaaa ggtcaaaatg caagaaatgc
    13021 gagtccttaa aggggaagtg aacaaatata aatacaattg gcgttgtgta ttggttgggg
    13081 catgttgcac gttgaggcta ataactcctg atgttttctt acaattagaa cggaagagaa
    13141 agcaagccag acatttcaaa atctttttga caaaattcaa gaaacacttc tttatctgtt
    13201 tcatctaaat tttcatcatc ataatttaga aattgtattt taaaatcctt taatatcaga
    13261 ctagatatac tgtcagtaat
//
LOCUS       DAUDWO010000048        13153 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.049, whole genome shotgun sequence.
ACCESSION   DAUDWO010000048 DAUDWO010000000
VERSION     DAUDWO010000048.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13153)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13153)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13153
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.049"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            1..71
                     /locus_tag="VHC05_001529"
     tRNA            1..71
                     /locus_tag="VHC05_001529"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:33..35,aa:Glu,seq:ttc)
     gene            105..178
                     /locus_tag="VHC05_001530"
     tRNA            105..178
                     /locus_tag="VHC05_001530"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:139..141,aa:Asn,seq:gtt)
     gene            complement(675..3251)
                     /locus_tag="VHC05_001531"
     CDS             complement(675..3251)
                     /locus_tag="VHC05_001531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfhO family protein"
                     /protein_id="HEQ5402821.1"
                     /translation="MKNNNKWIIAGLASFLFPLSIIFIILLSMGIYYNSDKTILASDA
                     FHQYVIFAQNFRNIMHGSDSFFYTFTSGLGINFYALMCYYLGSFFSPLLFFFNLTSMP
                     DAIYLFTLIKFGLIGLAACYSFHRLYPKISAFLMISISVFYSLMSFLTSQMELNSWLD
                     VFILLPLVVLGLNKLITENKTRTYYLSISLLFIQNYYFGYMIALFCILYALVCLLSLN
                     DFNKMFIAFVRFTAVSICAALTSALVILPTYLDLSTYGENLSPVKQLVTNNAWFLDIP
                     AKLSIGVYDTTKFNALPMIYVGLFPLMLSVIYFTLESIPLKIKLANACLLTFIIISFY
                     LQPLDLFWQGMHSPNMFLHRYAWSFSIVILLLACETLSRLTEVTQIKAGFAFIFLIIL
                     TSLPYSFSQQYNFLPLTLFLLSVFLLLGYTISLFSFRNSQIPSTFISAFILIFSLLES
                     GLNTYYQLQGINKEWGFPSRQIYNSQLKDINNLVNSVSKNSQPFFRMERLLPQTGNDS
                     MKFNYYGISQFSSVRNRLSSSLLDRLGFQSKGTNLNLRYQNNTIIMDSLLGIKYNLSE
                     GPLNKFGFTKLKTSGNTTLYQNHYSSPLAILTRNVYKDVNLNVNTLDNQTKLLNQLSG
                     KSLTYFNLQPAQLISGANQFNGQISAQASDYQNSVTLNYQINIPKHSQLYVSIPNIIF
                     SNPDAKEVRIQTDNHNFIYTTDNAYSFFDLGYFADAKVATFSFVFPKNKQISFKEPHF
                     YSLSIESYLEAMNSIKQKNVHTYAKSNTVITDYNSKTKGSLIFTLPYDKGWSAQKDGK
                     NLPVKKAQGGFLSVTIPKGKGRVILTFIPNGFKLGLSLSCVGIIAYMLLYKYIDIKSK
                     LL"
     gene            complement(3334..4953)
                     /locus_tag="VHC05_001532"
     CDS             complement(3334..4953)
                     /locus_tag="VHC05_001532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEQ5402822.1"
                     /translation="MLTVSDVSLRFSDRKLFDDVNIKFTAGNTYGLIGANGAGKSTFL
                     KILAGDIEPSTGHISLGPDERLSVLRQNHFDYEEERAIDVVIMGNEQLYNIMKEKDAI
                     YMKADFSEEDGVRAAELEGIFAELGGWEAESEASQLLQNLNIPEDLHYQNMSELANGD
                     KVKVLLAKALFGKPDVLLLDEPTNGLDIQSISWLEDFLIDFENTVIVVSHDRHFLNKV
                     CTHMADLDFGKIKLFVGNYDFWKQSSELAARLQADRNAKAEEKIKELQEFVARFSANA
                     SKSKQATSRKKMLDKIELEEIVPSSRKYPFINFKAEREMGNDFLTVENLSVTIDGEKI
                     IDNISFILRPGDKAAIIGQNDIQTTALMRALADDIDYEGTIKWGVTTSRSYLPKDNSK
                     DFATEESILEWLRQFASKGEDDDTFLRGFLGRMLFSGDEVKKSVNVLSGGEKVRVMLS
                     KLMLLKSNVLILDDPTNHLDLESISSLNDGIKDFKESVIFASHDHEFIQTIANHIVVI
                     SKNGVIDRIDETYDEFLDNPEVQARVAELWK"
     gene            complement(5032..5904)
                     /locus_tag="VHC05_001533"
     CDS             complement(5032..5904)
                     /locus_tag="VHC05_001533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEQ5402823.1"
                     /translation="MKKRGIDLLLVTIGSFITAIGFNTMFVDNHIASGGMVGIAVVIK
                     ALFGISPSLFLMASNIPLLLMCYFFLGKQNFIKTLYGSWIYPIAIRSTNSLPTLTHNQ
                     LLAAIFGGIICGIGLGMVFWGNSSTGGTGILTQILHKYSPLSLGVAMTIVDGISVLMG
                     FIALSADDVMYSTIGLFVIGYVISVMENGFDSSKNVMIISKDYQAIREYITTVMDRGV
                     TKLPIRGGYTTSDKIMLMAIVSSHELPTLQEKILEIDDTAFIVVMPAAQVMGRGFSLT
                     KQYKREDKDVLLPM"
     misc_binding    6027..6268
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            6323..7345
                     /gene="trpS"
                     /locus_tag="VHC05_001534"
     CDS             6323..7345
                     /gene="trpS"
                     /locus_tag="VHC05_001534"
                     /EC_number="6.1.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008087735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan--tRNA ligase"
                     /protein_id="HEQ5402824.1"
                     /translation="MTKPIILTGDRPTGKLHLGHYVGSLKNRVFLQNENKYKMFVFLA
                     DQQALTDHAKESELIQESIGNVALDYLSVGLDPRQSTIFIQSQIPELAELSMYYMNLV
                     SLARLERNPTVKTEIAQKGFGESIPSGFLVYPVSQAADITAFKANLVPVGNDQKPMIE
                     QTREIVRSFNHTYHTDCLVEPEGIYPENEKAGRLPGLDGNAKMSKSLGNGIYLSDDAD
                     TVRKKVMSMYTDPNHIKIEDPGQIEGNMVFHYLDIFARKEDQADIEAMKEHYQRGGLG
                     DVKTKRYLLDILERELAPIRERRLEYAKDMGEVFRMLQEGSQKARTVAAKTLSEVKSA
                     MGINYF"
     gene            7653..9134
                     /gene="guaB"
                     /locus_tag="VHC05_001535"
     CDS             7653..9134
                     /gene="guaB"
                     /locus_tag="VHC05_001535"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003085743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HEQ5402825.1"
                     /translation="MSNWDTKFLKKGYTFDDVLLIPAESHVLPNEVDLKTKLADNLTL
                     NIPIITAAMDTVTGSKMAIAIARAGGLGVIHKNMSITEQAEEVRKVKRSENGVIIDPF
                     FLTPEHKVSEAEELMQRYRISGVPIVETLANRKLVGIITNRDMRFISDYNAPISEHMT
                     SEHLVTAAVGTDLETAERILHEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKD
                     EFGRLLVAAAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNR
                     TLIAGNIATAEGARALYDAGVDVVKVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAR
                     KYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIYQGRKFKTYRG
                     MGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAASDIVFQMLGGIRSGMGY
                     VGAGDIQELHENAQFVEMSGAGLIESHPHDVQITNEAPNYSVH"
     gene            9337..10200
                     /locus_tag="VHC05_001536"
     CDS             9337..10200
                     /locus_tag="VHC05_001536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GRP family sugar transporter"
                     /protein_id="HEQ5402826.1"
                     /translation="MEGIFYALIPMFTWGSIGFVSNKIGGKPSQQTLGMTFGALLFSL
                     AVWLIVRPEMTLQLWLFGILGGFIWSIGQTGQFHAMQYMGVSVANPLSSGSQLVLGSL
                     IGVLVFHEWTRPMQFVVGSLALLLLIVGFYFSSKQDDANAQVNHLHNFSKGFRALTYS
                     TIGYVMYAVLFNNIMKFEVLSVILPMAVGMVLGAITFMSFKISIDQYVIKNSVVGLLW
                     GIGNIFMLLAASKAGLAIAFSFSQLGAIISIVGGILFLDETKTKKEMRWVVTGIICFI
                     IGAILLGVVKS"
     gene            complement(10256..11362)
                     /gene="recF"
                     /locus_tag="VHC05_001537"
     CDS             complement(10256..11362)
                     /gene="recF"
                     /locus_tag="VHC05_001537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="HEQ5402827.1"
                     /translation="MWIKELELKHYRNYDHLLASFSSGLNVFIGNNAQGKTNFLEAIY
                     FLSLTRSHRTRADKELIHFDHSTVSLTGKIQRISGTVDLEINLSDKGRVTKINALKQA
                     KLSDYIGTMMVVLFAPEDLQLVKGAPSLRRKFIDIDLGQIKPVYLFELSHYNHVLKQR
                     NSYLKSAQQIDAAFLAVLDEQLASYGARVMEHRIDFINALEKEANTHHQAISNGLESL
                     SLSYQSSVVFDKKTSIYQQFLHQLEKNHQKDFFRKNTSVGPHRDDLAFYINGMNANFA
                     SQGQHRSLILSLKMAEVSLMKALTGDNPILLLDDVMSELDNTRQTKLLETVIKENVQT
                     FITTTSLDHLSQLPEGIRIFHVTKGTVQVDSDIH"
     gene            complement(11364..11777)
                     /gene="yaaA"
                     /locus_tag="VHC05_001538"
     CDS             complement(11364..11777)
                     /gene="yaaA"
                     /locus_tag="VHC05_001538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S4 domain-containing protein YaaA"
                     /protein_id="HEQ5402828.1"
                     /translation="MIYKLFTEFITLQALLKELGIIQSGGAIKGFLAETTVLFNGEDE
                     KRRGKKIRIGDKISLPDQDLIIIIVEPNQEEKEQFAEEMAEKTRVAALVKQMNQANKK
                     TSSKHNNRQSTTKKSLRATKKTKGKPTAPVRFPGI"
     gene            12087..>13153
                     /locus_tag="VHC05_001539"
     CDS             12087..>13153
                     /locus_tag="VHC05_001539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HEQ5402829.1"
                     /translation="MKIVQGVQLHLIKTKQFKTNHITFRFSGDLNQKTVAKRVLVAQM
                     LATANECYPTVRQFREKLARLYGASLSTNVLTKGLVHIVDIDITFIQDRYACNGEKIL
                     DEMIQFLKDILFSPLLSIAQYQPKIFETEKNNLINYIESDREDSFYYSSLKVKELFYC
                     NKNLQMSEYGSPELIAKETAYTSYQEFHKMLNEDQIDIFILGDFDDYRVVQLIHQFPL
                     DNRNKNLNFFHLQTSVNIIKESIEKRAVHQSILQLAYHFPSVFGQRDYYALVLLNGLL
                     GSFAHSRLFVKIREEEGLAYSIGCRFDSYTGLFEIYTGIDSQHRTKTLQLIIQELNDI
                     KMGRLSEQLIKKTRSMLLNNA"
BASE COUNT         4308 a         2112 c         2455 g         4278 t
ORIGIN      
        1 gtccgttggt caaggggtta agacaccgcc ttttcacggc ggtaacacgg gttcgaatcc
       61 cgtacggact atcgcaattg tcattttggc aatttttttc tttttccggc atagctcagt
      121 tggtagtagc gcatgactgt taatcatgat gtcgtaggtt cgagtcctac tggcggagtg
      181 ataagatatt tcctaagata atcttaggat ttttttattt agtaaaacag atactcaggt
      241 caaatactca atttactaat tattaaacca ctaaatacag cattgtgaac taacagaatt
      301 gtattttgcg ttaaaataga agttctgttc tttaattgta tagatgataa cattaagttt
      361 aattacaaac attaactgaa gcttaatttt ttccattttg aaagcatgtc tcccatttaa
      421 tactgatgaa tataagatta ttgtaaggag tcaaaagatt gaaatcgtat cagcgatgat
      481 tattgtcatt tcaatctttg aaagagagta gtttaacatt aaccctcacg aaaaatctga
      541 cctttatatt atttgagttt attagtaaaa tcgataaaag catctcaagt attagaatat
      601 ttgtctagct cttgagatgc ttttagtata ttgactcatt tgccaaattg ataaaaaaat
      661 ctgatttttt tggactaaag taatttagac tttatatcta tgtacttata caaaagcata
      721 taagcgataa ttcctacaca agatagagat aaccctaatt taaaaccatt aggaataaag
      781 gtaaggataa cacgtccctt tcctttagga atagtaactg atagaaatcc tccttgtgct
      841 tttttgactg gaagattttt cccatctttt tgtgctgacc aacctttatc gtaaggaagt
      901 gtaaaaataa gagaaccttt cgtttttgaa ttataatcag tgattaccgt attactttta
      961 gcgtaagtat gaacattttt ttgtttaata ctattcattg cttcaaggta agattcaata
     1021 gacaaactat aaaaatgagg ttccttaaaa ctaatttgtt tattttttgg aaaaacaaac
     1081 gaaaatgtag caactttggc atcggcgaaa tatcctaaat caaaaaaaga gtaagcgtta
     1141 tctgtagtat atatgaaatt atgattatct gtctgaatac gcacctcttt agcatcagga
     1201 tttgaaaata taatattggg tatgctaaca tagagttgac tatgtttagg gatgttaatt
     1261 tgataattaa gggtaacgga gttttgataa tcagaagctt gtgcagatat ttgtccgtta
     1321 aattgattag caccagaaat aagttgagct ggctgtaagt taaaataggt taaagatttc
     1381 ccacttagtt ggttaagtaa tttggtttgg ttatcaaggg tattgacatt taggttgaca
     1441 tctttgtaaa cattacgtgt taatatagct aaagggctac tatagtgatt ttgataaaga
     1501 gtagtattcc cgctagtttt tagttttgta aatccaaatt tatttagagg tccttcgcta
     1561 agattatatt ttataccaag tagactgtcc ataataatag tattgttttg gtatctaagg
     1621 tttaaattcg tgcctttaga ctgaaatccc aatcgatcca ataaagaact agatagtcta
     1681 tttcttacag aggaaaattg tgaaatgccg taataattaa atttcatgct atcgttccct
     1741 gtttggggaa gtagtctttc cattctaaaa aaaggttgac tattttttga cacagagttg
     1801 acaaggttgt taatatcctt taattgacta ttatatatct gtcgtgatgg gaatccccac
     1861 tccttattaa ttccttgaag ttggtagtag gtgtttaacc ctgattcaag aaggctaaag
     1921 ataagtatga aagcagaaat aaaagtagat gggatttgag aatttctaaa cgaaaatagt
     1981 gaaatagtat aacctaataa taaaaaaaca ctaagtaaaa aaagagttaa aggtagaaaa
     2041 ttatattgtt gagaaaagct ataaggaaga gatgtcagta taatgaggaa aataaaagca
     2101 aaacctgctt ttatttgagt cacttctgtt agtcgagaga gagtctcaca tgcgagtaat
     2161 aggataacta tggaaaaaga ccaagcgtag cgatgcaaaa acatatttgg tgagtgcatt
     2221 ccctgccaaa aaagatcaag tggctgtagg taaaaactta ttataataaa agttaacaag
     2281 caggcattgg ctaattttat ttttaaaggg atactttcta aagtaaaata aataacacta
     2341 agcattaggg gaaataatcc tacgtaaatc ataggcagag cattaaactt ggtagtatcg
     2401 tacactccta ttgagagctt agcaggtata tccaaaaacc aagcattgtt cgtaactaac
     2461 tgttttaccg gggatagatt ctctccataa gttgacaaat ctagataggt aggaagtatt
     2521 actagagcac ttgttaaagc agcacatatt gacacagctg taaatctaac aaaagcgata
     2581 aacattttgt taaaatcatt gagacttaaa agacaaacta aggcgtaaag aatacaaaaa
     2641 agagcaatca tgtagccaaa gtagtaattt tgaatgaata ataatgatat cgaaagataa
     2701 taagttctgg ttttattttc tgtgataagt ttatttaatc caagtacaac aagtggaaga
     2761 agaatgaaaa catctaacca agaatttagt tccatttgac ttgtcaagaa gctcattaag
     2821 ctataaaaaa ctgagatgga aatcatcaag aaagcactga tttttggata taatctatga
     2881 aaagaatagc atgcagctaa tcctattaac ccaaatttta tcaaggtaaa caaatagata
     2941 gcatctggca tagaggttaa attaaaaaag aaaagtaatg gagaaaagaa actgccaaga
     3001 taataacaca ttaaagcata aaaatttatt cctagtccgc ttgtaaaggt ataaaaaaaa
     3061 ctatcagaac cgtgcatgat gttacgaaag ttctgcgcaa aaataacata ctgatgaaaa
     3121 gcatcactag ctagaattgt tttatcacta ttataataaa tgcccatcga tagaaggatg
     3181 ataaatataa tactaagagg gaacaaaaaa ctagcaagtc cagcaattat ccatttatta
     3241 ttatttttca taaattatat ggtctttcgt ttacaaattt taaaaaagag gctaggaaga
     3301 gatcttctta gccacctcat ttatcataag gttttatttc caaagttcag caactcgggc
     3361 ttggacttct ggattgtcaa ggaattcgtc ataagtttca tctatacggt cgataacacc
     3421 attttttgaa ataacaacga tgtggttagc aatcgtttga ataaattcat ggtcatgact
     3481 ggcaaagata acagattctt tgaagtcttt gatcccatca ttaagacttg aaatagattc
     3541 caaatccaag tgatttgttg gatcatcaag aataagaacg tttgatttca atagcatcaa
     3601 cttagaaagc atgacacgca ctttttcgcc accggaaaga acgttaacag attttttaac
     3661 ttcgtctcca gagaaaagca tccgtcctag gaaaccacgt aaaaaagtat catcatcttc
     3721 accttttgag gcaaattgac gtaaccattc aagaatagat tcttccgtgg caaaatcttt
     3781 tgaattgtct ttaggcaagt aagaacgact tgttgttact ccccatttaa tggttccttc
     3841 gtagtcaata tcatctgcta aagcacgcat aagagcagtt gtttgaatat cattttgacc
     3901 aataatagca gctttgtcac ctggacgtaa aatgaaactg atattatcaa tgattttctc
     3961 tccatcgatc gttacagaaa gattttcaac agtgaggaag tcattcccca tttcacgctc
     4021 tgctttaaaa ttaataaatg ggtatttacg gcttgaggga acaatttctt ctaattcaat
     4081 cttatcaagc atttttttac gagaggttgc ttgttttgat ttagatgcgt ttgctgagaa
     4141 acgggcaacg aattcttgta attctttgat tttttcttcg gctttagcat tgcggtcagc
     4201 ttgtaaacga gcggccagct cagaagattg tttccagaaa tcgtagttac ccacaaagag
     4261 tttgatttta ccaaagtcaa ggtcggccat gtgagtacat actttattca agaagtgacg
     4321 gtcatgggaa acaacgatga ctgtattttc aaaatcaatc aagaaatctt ccaaccatga
     4381 aatagattga atatcaagac cattggttgg ctcgtcaagt aataaaacgt caggcttacc
     4441 aaagagcgct ttagcaagaa ggactttcac tttatctcca ttagccagtt cactcatatt
     4501 ttggtagtga aggtcttctg gaatatttag attttggaga agttgagaag cttcactttc
     4561 tgcctcccag ccacctaatt cagcaaagat accttctagc tcagcggcac gaaccccatc
     4621 ttcttctgaa aaatctgctt tcatatagat agcgtctttt tctttcatga tattgtaaag
     4681 ttgctcatta cccatgatta caacatcaat cgcacgttct tcttcataat caaaatgatt
     4741 ttggcgaaga acagataagc gttcgtcagg tcctaaagag atatgaccag tacttggttc
     4801 aatatctcct gcaaggattt taagaaaagt tgattttccg gcaccattcg caccgattaa
     4861 gccgtaagta ttgccggctg tgaatttgat attaacatca tcaaatagtt ttcgatcact
     4921 aaagcgtagt gatacatcag aaactgtaag caatttgtca cctcatttta tttatctaag
     4981 cttcattgta cctaaaatag tccccttttt caatcagaaa agggctaatc actacatagg
     5041 caataaaacg tctttgtctt cacgtttgta ttgtttagtc aaactaaatc ctcttcccat
     5101 aacttgagct gctggcatga caacaataaa ggctgtatcg tcaatttcga ggattttttc
     5161 ttggagagta ggtaattcgt gacttgatac aatagccatt aacataattt tatcagaagt
     5221 agtataacca ccgcgaatag gaagtttagt cactccacga tccataacag ttgtgatata
     5281 ttctcgaata gcttgataat ctttggaaat aatcataaca tttttggatg agtcaaagcc
     5341 attttccata acactaatca cataaccaat tacgaaaagt ccaatcgtag aatacatcac
     5401 gtcatctgca gaaagtgcaa taaatcccat aaggacacta ataccatcta caattgtcat
     5461 tgcaactcca agagataaag gagagtattt atgaagtatt tgtgttagaa ttccagttcc
     5521 tcctgtcgaa gagtttcccc aaaaaaccat tcctaaacca atgccacaga taataccacc
     5581 aaaaatagct gctaacaact gattgtgtgt cagagtaggt aatgaattgg ttgaacggat
     5641 ggcaatagga tatatccaag aaccataaag tgttttaata aaattttgtt ttccaagaaa
     5701 gaagtaacac attaataata agggaatatt actagccatt aaaaaaagcg acggactaat
     5761 gccaaataga gcttttataa caactgcaat accaaccata ccccctgatg caatatgatt
     5821 gtcgacaaac attgtattga aaccaatagc tgttatgaat gagccaattg tgacaagtag
     5881 taaatcaatc cctcgttttt tcatgctttt aatctccttt ataactggtt aaaaatagta
     5941 gactcattat ctcttaaatg tactgagacc gtcaagtcat attttcaaaa aatctggtga
     6001 acttgacaag aagtttaaaa tttcatagaa taaatctaaa ttagaagagt attcttttca
     6061 tgtttttaga gagttagtgg tcggtgcaag ctaacaacag aaaaggtgaa atggactaat
     6121 gattatttga aaggaaacca taactttcag gttggcaccc cttaccgtgc agcttctttc
     6181 attgagaaga ttgagatagt atctcgtttt gataaagcag atgctaattg aggtggtacc
     6241 gcgtattact tgtaataacg ccctcacgtt ttaatagcgt ggggactttt tgctatatca
     6301 agagatagtt agggagaaaa tgatgacaaa acctattatt ttaactggag atagaccaac
     6361 tggaaaatta catttaggtc attatgtcgg aagtcttaaa aatcgtgtct ttttacaaaa
     6421 tgaaaacaag tataagatgt ttgttttctt ggccgatcaa caggcactga cggatcatgc
     6481 taaagaatcc gaattaattc aagaatctat tggaaatgtt gccttggatt acctctctgt
     6541 cggtttggat ccgaggcaat caacgatttt tattcaaagt cagattccag agctagctga
     6601 attgagcatg tattatatga atctggtatc attagcacgt ttggaaagaa atcccactgt
     6661 taaaaccgaa attgctcaga aaggttttgg cgaaagtatt ccatctggtt ttttggttta
     6721 tccagtatca caggccgctg atattacagc atttaaagcg aatttagtac ctgtaggtaa
     6781 cgaccagaaa ccgatgattg aacaaacacg tgaaattgtg agaagtttta atcatactta
     6841 ccatacagac tgtttagtag aacctgaagg tatttatcca gaaaatgaaa aagctggacg
     6901 cttacctggt cttgatggca atgccaaaat gtctaaatca ttgggaaatg gaatctatct
     6961 ttcagatgat gcagataccg ttcgcaaaaa agtgatgagc atgtatactg atccaaatca
     7021 tattaaaata gaagatcctg gtcaaattga agggaatatg gtctttcatt atttggatat
     7081 ttttgctaga aaagaagatc aagctgatat cgaagcaatg aaagagcatt atcaaagagg
     7141 tggtttagga gatgtgaaaa cgaaacgcta ccttctagat attttagaac gtgaattagc
     7201 acctattcgt gaaagacgtt tggagtacgc taaagatatg ggagaggtgt tccgtatgtt
     7261 acaagaaggt agtcaaaaag caagaactgt ggcagccaag actttatcag aagtgaagtc
     7321 agcaatgggt attaattatt tttaatgttt tagagaaaaa gctaagttag taatgataag
     7381 ataattacta ttatcaaagc aggacctaat ttgtcatttc tttacaggat agtagagatt
     7441 atgttttata tagtcttatt tttgattaaa aataagaccc aaatgaattt tttgattaat
     7501 aaaaaacgga taatactgat atattatgct gatagtgact tcagctgtag gaatatttta
     7561 ttgacaaatg attttagcgt gatatgatag taacaataaa aaatagacta gggtaatatt
     7621 ccctaaaaat aaaagaaaag aggattatct ggatgtcaaa ttgggacact aaatttttga
     7681 aaaaaggcta cacttttgac gatgtcttgc ttattccggc agagagtcat gttcttccaa
     7741 atgaagttga tttaaagaca aagctcgcag acaatttgac attaaatatt cctattatta
     7801 cagcagctat ggatacggtt actggtagta aaatggctat tgcaattgcg cgtgcgggtg
     7861 gtttaggtgt tattcataaa aacatgtcta ttactgagca agcagaagaa gttcgcaagg
     7921 taaaacgttc tgaaaatggt gtcatcattg atccattctt cttaacacct gaacacaagg
     7981 tttcagaagc tgaagaatta atgcagcgct accgtatcag tggtgtgcca attgttgaaa
     8041 ctttagcaaa ccgtaagttg gtcggtatca ttactaatcg tgatatgcgt tttatttctg
     8101 attacaatgc accaatctct gaacatatga ctagtgagca cctcgttacg gctgctgttg
     8161 gtacagatct tgaaactgca gaacgtattc ttcatgaaca ccgtattgaa aaacttcctt
     8221 tggttgataa tagcggtcgt ctgtctggtt taatcactat caaagatatt gaaaaagtaa
     8281 tcgaattccc acatgctgct aaagatgaat ttggtcgtct tctggtcgct gctgcggtag
     8341 gtgttacctc agatactttt gagcgtgccg aggccttgtt tgaagctggt gcagatgcga
     8401 ttgttattga cacagctcat ggtcattcgg ctggtgttct tcgtaaaatt gctgagattc
     8461 gtgctcattt cccaaatcgt actttgattg ctggaaatat tgccactgct gaaggtgcgc
     8521 gtgctcttta tgatgcaggt gtcgatgttg ttaaagtggg tattggtccc ggatctatct
     8581 gtaccactcg tgtggttgca ggtgtcggtg ttcctcaagt gactgctatt tacgatgctg
     8641 ctgctgttgc tcgtaaatat ggcaaaacga ttattgctga tggtggtatc aagtattctg
     8701 gcgatattgt taaggctctt gcagccggcg gtaatgctgt tatgcttgga tcaatgtttg
     8761 caggtactga tgaagctcca ggtgaaactg aaatctacca aggccgtaag ttcaaaactt
     8821 atcgtggaat gggttccatt gcagctatga agaaaggatc aagcgatcgt tacttccaag
     8881 gttccgtaaa tgaagctaat aaactagttc cagaaggtat tgaaggccgt gttgcttata
     8941 aaggagctgc ttcagatatt gtcttccaaa tgttaggtgg tatccgctca ggtatgggct
     9001 atgttggcgc aggtgacatt caagaattac atgaaaatgc tcaatttgtt gaaatgtcag
     9061 gtgcaggctt gattgaaagt catccacatg atgtccaaat cacaaatgaa gcaccaaact
     9121 attctgtgca ctgataattt aatttagtaa ctttaagggc tgacatattg tgccagctct
     9181 ttttttatat taaaaaatga taaaatataa taacaatttt cggataactt ttattgtttt
     9241 ttcttagtaa ataagctata attagtcttt acatgaaacc attttatgat agaattatta
     9301 taatctttaa aggtttacta taaaggagat aacattttgg aaggtatttt ttatgcactt
     9361 attcccatgt ttacatgggg aagcattgga tttgttagta acaaaattgg aggaaaacct
     9421 tcgcaacaaa ctctaggaat gacttttggg gctttattat tttcattagc tgtttggtta
     9481 attgttagac ctgagatgac actgcaactt tggctttttg gaatattggg tggttttatc
     9541 tggtcaattg gtcaaactgg tcaatttcat gccatgcaat acatgggagt ctccgttgcc
     9601 aatcctttgt caagtggctc tcaacttgtt ctgggaagtt tgattggtgt gctcgttttt
     9661 catgaatgga caagacctat gcaatttgta gtaggaagtc tagcactatt acttctgatt
     9721 gttggttttt acttttctag taaacaagat gatgctaatg cacaagtcaa tcaccttcat
     9781 aatttttcaa aaggatttag ggcgctcact tattcaacaa ttggttacgt gatgtatgct
     9841 gtattattta ataacatcat gaaatttgaa gttttgtcag tcattttacc catggcagta
     9901 ggtatggttt taggagctat aactttcatg tcatttaaaa tttccattga ccagtatgtg
     9961 attaaaaata gcgttgttgg attactttgg ggcattggga atatttttat gcttttagct
    10021 gcatcaaaag caggacttgc tattgccttt agtttctcac aattaggtgc tatcatttcg
    10081 attgtcggag gcattttatt cctagacgaa accaaaacca aaaaagaaat gcgttgggtt
    10141 gtcacaggta ttatctgttt tatcataggt gcgattttat taggtgtggt caaatcttaa
    10201 tcgccacata acatcaaaaa aaggctcagt ttaactgaac ccttttttga tgttattagt
    10261 gaatgtcaga atcaacttga acggttcctt ttgtcacgtg aaaaatacgg ataccttctg
    10321 gcaactgtga caggtgatcc aaacttgttg ttgtgataaa ggtttggaca ttttctttaa
    10381 ttactgtttc aagtaacttt gtttgtcgtg tattgtctag ctcgctcatg acatcgtcta
    10441 gtaaaagaat gggattatct ccagtcaagg ccttcattaa actaacttca gccattttta
    10501 aggaaagaat aaggctgcgg tgctgacctt gactagcaaa gttagcattc atcccgttaa
    10561 tgtaaaaggc taagtcatcg cgatgtggac caacactagt gtttttacgg aagaaatctt
    10621 tctgatgatt tttttcaagt tggtgtaaaa attgttggta aatactagtt tttttgtcaa
    10681 agacaactga cgactgatag gagagagaga gactttctaa accatttgag atggcttggt
    10741 gatgagtatt tgcttctttc tctaacgcat tgataaaatc aatacgatgt tccatgacac
    10801 gggctccata gctagctaat tgctcatcta gaacagctag aaaagcggca tcaatttgtt
    10861 gggcactttt taaatagcta ttacgctgtt taagcacgtg gttataatgg gataactcaa
    10921 ataagtaaac aggcttaatt tgaccaaggt caatgtcgat aaatttgcga cgaaggctag
    10981 gtgctccctt aactagttgc aaatcttctg gtgcgaaaag cacaaccatc atcgttccaa
    11041 tataatcaga taattttgct tgctttagcg cattaatctt tgtcacacgt cctttatctg
    11101 atagattgat ttctaaatca acagtaccac taatacgctg aatcttacca gtaagagaaa
    11161 cagttgagtg atcaaaatga atcaattctt tatcagccct cgtgcgatga cttctagtaa
    11221 gtgatagaaa atagattgcc tcgagaaaat tggtttttcc ttgagcatta ttaccgataa
    11281 agacatttaa acccgacgaa aatgaggcaa gcaggtggtc ataattgcga taatgtttta
    11341 actctaactc tttaatccac atactagata cctgggaagc ggacaggtgc agttggttta
    11401 cctttagttt tcttagttgc tcttagtgat tttttggtag tagattgacg attgttatgt
    11461 ttagaagaag tctttttgtt agcttggttc atttgtttca ctagagccgc tacacgtgtc
    11521 ttttcagcca tttcttcggc aaattgttct ttttcttctt gattaggctc aacaataatg
    11581 ataattaagt cttggtcagg tagagaaatc ttatccccta ttctgatttt tttgcctcga
    11641 cgtttctcat cttcaccatt aaatagaacg gttgtttcag cgagaaatcc cttgatagcg
    11701 ccaccacttt ggataattcc taattcttta agaagggctt gtagggtgat aaattctgta
    11761 aataatttgt atatcattgt catctccatt ttgtcattca agtcattata gcataaaaca
    11821 gaaataaata ataatagctg aataagagct atttgactat tccaaagtga gacgttattt
    11881 gatataatat aatctgtatt tttaagtata aagtgtggtt gaaacttttt agaggtatta
    11941 ctggctttat tttgcagtaa atcataggag caagtcaatt gcttcttttt ttgtttaacc
    12001 gtaaggaatt taaaaagtta tcactcacct aacctgaata aaaatggtat aatcgtaagg
    12061 atcacactat ttattaagga aacattatga aaattgttca gggagtacaa cttcatctga
    12121 ttaagaccaa acagtttaaa accaatcata ttacctttcg tttttcaggt gatttgaacc
    12181 aaaaaacagt agcaaaaaga gtcttagtgg cacagatgtt agcaacagct aatgagtgtt
    12241 atccaactgt taggcagttt agagaaaaat tagcacgact ttatggagct agcttgtcaa
    12301 ctaacgtgtt aacaaaaggg ttagttcata ttgtggatat cgatattact tttattcaag
    12361 atagatatgc ttgcaatggg gaaaaaatac tagatgaaat gattcagttt ttaaaagata
    12421 tcttgttctc acccctatta tccatcgccc agtatcagcc taaaattttt gagactgaaa
    12481 aaaataattt gattaactac atcgagtcag atagagagga ttctttttac tacagctctc
    12541 ttaaggtaaa agaattgttt tattgtaata agaatctaca aatgtcagaa tatggtagcc
    12601 cagaactaat tgcaaaagag actgcctata ctagctatca agaatttcat aaaatgctca
    12661 atgaagatca gattgatatt ttcattttag gagattttga tgattatcgc gttgttcagc
    12721 taattcatca atttccactt gataaccgaa ataaaaacct aaatttcttt catttacaaa
    12781 cttctgtcaa tattattaaa gaatctattg aaaaaagagc agttcatcaa tctattttac
    12841 aattagctta tcacttccct tcagtttttg gacaacgtga ctattatgct ttagttcttt
    12901 taaatgggtt gttaggctct tttgcacatt cccgtctctt tgtaaaaatt agagaagaag
    12961 aaggacttgc ttatagtata gggtgtcgtt ttgatagtta tacaggttta tttgaaattt
    13021 atactggaat tgacagtcaa catcgcacaa aaacgttaca actaatcatc caagaattaa
    13081 atgacattaa aatgggacga ttatcagaac aattgattaa aaagaccagg tcgatgttgt
    13141 tgaataatgc ctt
//
LOCUS       DAUDWO010000049        12375 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.050, whole genome shotgun sequence.
ACCESSION   DAUDWO010000049 DAUDWO010000000
VERSION     DAUDWO010000049.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12375)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12375)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12375
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.050"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(81..1340)
                     /locus_tag="VHC05_001540"
     CDS             complement(81..1340)
                     /locus_tag="VHC05_001540"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HEQ5402830.1"
                     /translation="MRKIIINGGKALSGEVAVSGAKNSVVALIPAIILADDIVILDGV
                     PAISDVDSLIEIMELMGATVNYHGDTLEIDPRGVQDIPMPYGKINSLRASYYFYGSLL
                     GRFGQAVVGLPGGCDLGPRPIDLHLKAFEAMGVEVSYEGENMNLLTNGQKIHGAHIYM
                     DTISVGATINTMVAATKAQGKTVIENAAREPEIIDVATLLNNMGAHIRGAGTDIITIQ
                     GVQKLHGTRHQVIPDRIEAGTYIALAAAIGKGVKITNVLYEHLESFIAKLEEMGVRMT
                     VEEDAIFVEKQESLKAITIKTSPYPGFATDLQQPLTPLLLKADGRGTIIDTIYEKRIN
                     HVPELMRMGADISVIGGQIVYQGPSRLTGAQVKATDLRAGAALVIAGLMAEGKTEITN
                     IEFILRGYASIIAKLTALGADIQLIED"
     gene            complement(1514..2710)
                     /locus_tag="VHC05_001541"
     CDS             complement(1514..2710)
                     /locus_tag="VHC05_001541"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HEQ5402831.1"
                     /translation="MSERKLFTSESVSEGHPDKIADQISDAILDAILAEDPEAHVAAE
                     TCVYTGSVHVFGEISTTAYIDINRVVRDTIAEIGYTEAEYGFSAESVGVHPSLVEQSG
                     DIAQGVNEALESREGDTDDLSHIGAGDQGLMFGFAINETPELMPLPISLSHQLVRRLA
                     ELRKSGEISYLRPDAKSQVTVEYDEHDKPVRVDTVVISTQHDPEATNDQIRQDVIEKV
                     IKDVIPADYLDDDTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSG
                     KDATKVDRSASYAARYIAKNLVAAGLATKAEVQLAYAIGVAQPVSVRVDTFGTSTVPE
                     AVLEAAVRQVFDLRPAGIIQMLDLKRPIYKQTAAYGHMGRTDIDLPWERLNKVDALVE
                     AVKTVL"
     gene            complement(3247..5559)
                     /locus_tag="VHC05_001542"
     CDS             complement(3247..5559)
                     /locus_tag="VHC05_001542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HEQ5402832.1"
                     /translation="MKTKKVIILVGLLLSSQLTLIACQSRGNGTYPIKTKQSRKGMTS
                     NKIKPIKKSKKTNKTHKGVAGVDFPTDDGFILTKDSKILSKTDQGIVVDHDGHSHFIF
                     YADLKGSLFEYLIPKGASLAKPAVAQQAASQGTSKVADPHHHYEFNPADIVAEDALDY
                     TIRHDDHFHYILKSSLSGQTQAQAKQVATRLAQTSSPVSTATANGIPGLHFPTSDGFQ
                     FNGQGIVGVTKDSILVDHDGHLHPISFADLRQGGWAHVADQYDPAKKAEKPAETHHTP
                     ELSEREKEYQEKLAYLAEKLGIDPSTIKRVETQDGKLGLEYPHHDHAHVLMLSDIEIG
                     KDIPDPHAIEHARELEKHKVGMDTLRALGFDEEVILDIVRTHDAPTPFPSNEKDPNKM
                     KDWLATVIKLDLGSRKDPLQCKGLSLLPNLETLGLGFTPIKDISPVLQFKKLKQLLMT
                     KTGVTDYRFLDNMPQLEGIDISQNNLKDISFLSKYKNLTLVAAADNGIEDIRPLGQLP
                     NLKFLVLSNNKISDLSPVSHKESLTVVDLSRNADVDLATLQAPKLETLMVNDTKVSHL
                     DFLKNNPNLSNLSINRAQLQSLEGIEASSVIVRVEAEGNQIKSLVLKDKQGSLTFLDV
                     TGNQLTSLEGVNNFTALDILSVSKNQLTNVNLSKPNKTVTNIDISHNNIPLADLKLNE
                     QHIPEAIAKNFPAVYEGSMVGNGTAEEKAAVATKAKESAQEASESHDYNHNHTYEDEE
                     GHAHEHRDKDDHDHEHEDENEAKDEQNHAD"
     gene            5762..6703
                     /locus_tag="VHC05_001543"
     CDS             5762..6703
                     /locus_tag="VHC05_001543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional biotin--[acetyl-CoA-carboxylase]
                     synthetase/biotin operon repressor"
                     /protein_id="HEQ5402833.1"
                     /translation="MKTSEKIYQLLSQTDDFVSGEYLADQLSISRTSVWKSIKSLENQ
                     GIQIDSLKHKGYRMVQGDILLPKTISQGLGMPVTYTPHSQSTQLDAKQGIEAHNSAPR
                     LYLAPSQEAAKGRLDRQFFSASTGGIYMSMYLKPNVPYTDMPPYTMMVASSIVKAISR
                     LTGIDTEIKWVNDIYLGNHKVAGILTEAITSVETGLITDVIIGVGLNFFVTDFPEAIA
                     QKAGSLFTEKPTITRNDLIIDIWKLFLSIPVKDHVKVYKEKSLVLNKQVTFIENSQEK
                     RAIAIDLTDQGHLIVQFENGDLQTLRSGEISLSSWEN"
     gene            complement(6678..6881)
                     /locus_tag="VHC05_001544"
     CDS             complement(6678..6881)
                     /locus_tag="VHC05_001544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3272 domain-containing protein"
                     /protein_id="HEQ5402834.1"
                     /translation="MTIRQFLFMAFVCAFETYFFNDLLLSGNYLFALFWGLLLFRDLR
                     RVHTINQLTKTILKTANSPKKKD"
     gene            complement(6976..8646)
                     /gene="dnaX"
                     /locus_tag="VHC05_001545"
     CDS             complement(6976..8646)
                     /gene="dnaX"
                     /locus_tag="VHC05_001545"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="HEQ5402835.1"
                     /translation="MYQALYRKYRSQTFDEMVGQSVISTTLKQAVESGKISHAYLFSG
                     PRGTGKTSAAKIFAKAMNCPNQVDGEPCNQCDICRDITNGSLEDVIEIDAASNNGVDE
                     IRDIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFILATTELHK
                     IPATILSRVQRFEFKAIKQKAIREHLAWVLDKEGIAYEVDALNLIARRAEGGMRDALS
                     ILDQALSLSPDNQVTIAIAEEITGSISILALGDYVRYVSQEQATQALAALETIYDSGK
                     SMSRFATDLLTYLRDLLVVKAGGDNQRQSAVFDTNLSLSIDRIFQMITVVTSHLPEIK
                     KGTHPRIYAEMMTIQLAQKEQILSQANLSGELISEIETLKNELAQLKQQLSQLQSRPD
                     SLARSDKTKSKTTSYRVDRVTILKIMEETVRNSQQSRQYLDALKNAWNEILDNISAQD
                     RALLMGSEPVLANSENAILAFEAAFNAEQVMSRNNLNDMFGNIMSKAAGFSPNILAVP
                     RTDFQHIRKEFAQQMKSQKDSVQEEQEVALDIPEGFDFLLDKINTIDD"
     gene            complement(8646..9143)
                     /locus_tag="VHC05_001546"
     CDS             complement(8646..9143)
                     /locus_tag="VHC05_001546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GAF domain-containing protein"
                     /protein_id="HEQ5402836.1"
                     /translation="MNKSKKIEQYQLMIAQAKELFANESNALANLSNASALLNMTLPN
                     SVFTGFYLFDGQELILGPFQGRVSCVHIKLGKGVCGESAQSRRTIIINDVKQHANYIS
                     CDAAAMSEIVVPMVKEGHLIGVLDLDSSLVADYDEVDQEYLETFVDLLLEKTTFTFNM
                     FGVKN"
     gene            9288..10097
                     /locus_tag="VHC05_001547"
     CDS             9288..10097
                     /locus_tag="VHC05_001547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrsW family intramembrane metalloprotease"
                     /protein_id="HEQ5402837.1"
                     /translation="MKQITQQKWLRYGLFIALVLNGIELELLGLTANNLSFKEAFALI
                     LTISLLGIYLIPFAAAIFYLSKKFHMNLNVIIVSCLSGLYISGFLASCGNHLVGQFWS
                     YIIPSKDALKLWGDALTAPIVEEPIKASSAILVITLFPRLTLKEKLVVALLSGMGFQL
                     TEDIRYLIQAKSIDSLVPTAIERISTAVTSHWVHTAIFTIGAYLLLKGSNLFSKQQQI
                     FWLLSPLVLHFIWNSPLTSIPGMTVLLGTLILLIFGDLFQKINTLDDDVLF"
     gene            complement(10150..10413)
                     /locus_tag="VHC05_001548"
     CDS             complement(10150..10413)
                     /locus_tag="VHC05_001548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1294 domain-containing protein"
                     /protein_id="HEQ5402838.1"
                     /translation="MLLIWLGLLFVWNELVFVIYAFDKRKAIKKKRRISERNLLVITV
                     LFGGFGALLAAKKYHHKTRKWYFVITWYTSILLTLLVTYIFMK"
     gene            complement(10493..11119)
                     /gene="udk"
                     /locus_tag="VHC05_001549"
     CDS             complement(10493..11119)
                     /gene="udk"
                     /locus_tag="VHC05_001549"
                     /EC_number="2.7.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012515313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uridine kinase"
                     /protein_id="HEQ5402839.1"
                     /translation="MLKKPIIIGVTGGSGGGKTSVSRAILDSFPNARIAMIQHDSYYK
                     DQSHMSFEERVKTNYDHPLAFDTDFMIQQLKELLAGRPVDIPIYDYKKHTRSNTTFRQ
                     DPQDVIIVEGILVLEDERLRDLMDIKLFVDTDDDIRIIRRIKRDMMERGRSLESIIDQ
                     YTSVVKPMYHQFIEPSKRYADIVIPEGVSNVVAIDVINSKIASILGEV"
     gene            11217..12302
                     /locus_tag="VHC05_001550"
     CDS             11217..12302
                     /locus_tag="VHC05_001550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEQ5402840.1"
                     /translation="MITKFPPQWQEKLDQVAFTHLTPIQEQAFQPIVDGKNFLGISPT
                     GTGKTLAYVFPSLLALTPKKSQQLLILAPNTELAGQIFEVTKDWAQPLGLTAQLFISG
                     TSQKRQIERLKKGPEILIGTPGRIFELIKLKKIKMMSVNTIVLDEYDELLGDSQYDFV
                     QKISHYVPRDHQMVYMSATNKVDQTSLAPNTFCIDLSEQTNDAIQHFYLMVDKRERTD
                     LLRKFANIPHFRALVFFNSLSDLGATEERLQYNGAAAVSLASDINVKFRKTILEKFKS
                     HQLSLLLATDLVARGIDIDNLDYVIHFDVARDKENYTHRAGRTGRMGKSGIVITFVSH
                     PEDLKKLKKFAKVSEISLKNQQLHFIN"
BASE COUNT         3730 a         2604 c         2147 g         3894 t
ORIGIN      
        1 ataaaatgca acaaagtatg cacctaagta tcattagcct aagcacatgt aatataaaaa
       61 agagaagcgt tagcttctct ttagtcttcg attaattgaa tatctgcccc tagtgctgtt
      121 aattttgcaa tgatactagc atagccacgt aagataaatt caatattagt aatttctgtc
      181 ttgccttcag ccattagacc agcaatcact agagccgctc cggcacgtaa atcagtggct
      241 ttgacctgag ctcctgtcaa gcgagacggc ccttgataaa caatctgacc accaataact
      301 gagatatctg ctcccatgcg catcaactct ggcacatggt taatgcgctt ttcatatata
      361 gtgtcaataa tcgttccacg accatctgct tttaacaaca agggcgttaa tggctgttgc
      421 aaatcagtgg caaagccagg gtaaggagag gttttaattg taatagcctt gagggattct
      481 tgcttttcaa caaagatagc atcctcttct accgtcatac ggacacccat ttcttctaac
      541 ttagcaatga aactctctaa atgctcataa agaacattag tgatcttaac accttttcca
      601 atagctgccg ccaaagcgat ataagtccct gcttcaatac gatcaggaat aacttggtgt
      661 ctagtaccat gcaatttctg aacaccttgt atcgtaataa tatctgtacc tgctccacga
      721 atatgcgcac ccatgttatt caaaagagta gccacatcaa taatctctgg ctcacgtgca
      781 gcgttttcaa taaccgtttt accttgagct tttgttgccg caaccatagt attaattgta
      841 gcaccgacac taatggtgtc catatagata tgagcgccat gaattttttg accatttgtc
      901 aataaattca tattttcacc ctcataagac acttcaactc ccatagcctc gaaggccttc
      961 aaatgcaagt caattggtct tggtcctaaa tcgcaaccac caggtaagcc aacaactgct
     1021 tgtccaaaac gacctaaaag actaccgtag aaataatagg aagctcgaag actattaatc
     1081 tttccgtaag gcatcgggat gtcttgcacc cctctagggt caatttctaa agtatcacca
     1141 tgatagttta ctgttgctcc cataagctcc atgatttcaa tcagactatc tacatcacta
     1201 atagcaggta caccatcaag aatcacaata tcatcggcta agatgattgc tggaataagc
     1261 gcaacaacac tgttttttgc ccctgaaact gccacttctc cagataaggc ttttccgcca
     1321 ttaataataa ttttacgcat acattcaaaa ctttcttata ctagaattca accttttcat
     1381 tttatcataa atcatgaagc ctgacaatta ttgacgtctt aatttttaat catccctttt
     1441 aaaggcttat ttaataacaa aaaagcagag taagattttt tcactcactc tactttttta
     1501 ataaagttgt catttataat actgttttta cagcttctac taaagcatca accttattta
     1561 aacgctccca tggcaaatca atatctgttc tccccatgtg accataggca gctgtttgtt
     1621 tgtaaatcgg gcgttttaaa tcaagcattt gaataatgcc tgctggccgt aaatcaaaga
     1681 cttgacgaac agcagcttct aaaacagctt caggaaccgt tgaggttcca aatgtatcca
     1741 cgcgaacaga cacaggctga gccaccccaa tcgcataagc tagttggact tcagctttgg
     1801 tcgcaaggcc tgctgccaca aggtttttag caatatagcg agcagcgtaa gaagccgaac
     1861 ggtcaacttt tgtcgcatct tttcctgaaa aagcaccgcc accatgacgt gaatagcctc
     1921 cataggtatc cacaataatc ttacgtccgg tcaatccaga gtctccttgc ggacctccaa
     1981 taacaaaacg tcctgttgga ttaatgaaga actttgtgtc atcatctaaa taatctgctg
     2041 gaattacatc cttgatcact ttttcaatca catcctgacg aatttggtca ttagtagctt
     2101 ctggatcgtg ctgagtagaa ataacgactg tatccacacg aacaggttta tcgtgttcat
     2161 cgtactcaac tgtcacttga gatttagcat ctggacgtag ataactaatc tcacctgact
     2221 tacgtaattc cgccaagcga cgcactaatt ggtgagataa ggaaattggt aaaggcatca
     2281 attctggtgt ttcattgatg gcaaaaccaa acatgagccc ttggtcaccc gctccaatat
     2341 ggctaaggtc atcagtatca ccttctctgc tttcgagagc ttcattaacc ccctgagcga
     2401 tatctccaga ttgttctaca agtgatggat gtactcccac tgattctgct gaaaagccat
     2461 attctgcttc tgtataacca atttctgcaa tggtgtcgcg gaccacacgg ttaatatcaa
     2521 tgtatgctgt tgttgagatt tctccaaaaa catgaacaga acctgtgtaa acacaagttt
     2581 ctgcagccac atgggcttct ggatcttctg ctaaaatggc atctaaaata gcatctgaaa
     2641 tttggtctgc aatcttatct ggatgccctt cagatacgga ctcagacgtg aaaagtttac
     2701 gttctgacat aaaaatgtcc cccctaatat gttgattctt cctttttcag tcacattgac
     2761 cacaaagcaa gaagttgcct acccctttct tcctagctga ttaagcaagt caagtggcca
     2821 aaaccaactt agctaatcag ttacggtttt actagtaagg caactagcta gtccacctag
     2881 tggctagcgt ccattaacca gacaaagaat gtctgacaat agcgttgagt tacaaagaat
     2941 ccggtctcct tgttgagagg atgtcaccac aaaataagcc ttagacgaag taatttagct
     3001 aaagggagaa cgactgttcc ccaaataaag tcaacaacgt ctcaaaaaca tttcgttcga
     3061 cagaccgtct tatcgggact caataacaat ctattataac atgttttagc catttaggtg
     3121 ccattctttt cactcattat cctatttatt tcaaaaaaac ctcaaggtta ttcttgaggt
     3181 tttcttgata gtcaacaatg gtgtcattag gacgattcag ttggataggg ttattcttag
     3241 attagtttag tcagcatggt tttgctcatc tttagcttca ttttcatcct catgttcatg
     3301 gtcgtgatca tctttgtctc tgtgctcgtg agcatgacct tcttcatctt cataggtatg
     3361 attatggttg tagtcatgtg attccgatgc ttcttgagca ctttctttcg ccttagtagc
     3421 cacagctgct ttttcttcag ctgttccatt acctaccata gaaccttcgt aaaccgctgg
     3481 gaagtttttc gcaatggctt ctggaatatg ttgctcgttc aatttaaggt ctgccaatgg
     3541 gatattgtta tgactaatat caatgttagt aactgtctta ttgggtttag ataggttgac
     3601 atttgttaat tggtttttag acacgcttaa aatgtcaagt gctgtaaaat tattaacacc
     3661 ttctagagaa gtcaactggt tgcctgtcac atccaagaaa gtaagtgacc cttgcttgtc
     3721 tttaagcaca agcgatttaa tttggttacc ttctgcttct actctgacaa tgacgctact
     3781 tgcttcaata ccttcaagag attgcaattg cgcacggtta atagataggt tagatagatt
     3841 aggattattt ttcaagaaat ccaaatgaga aaccttggta tcattgacca ttaacgtttc
     3901 taatttgggt gcttgaagtg ttgctaagtc aacatcagca tttcttgata aatcaacaac
     3961 cgtcaatgat tctttatgag aaacagggct taaatcagaa attttattat tactcaatac
     4021 gaggaatttg agatttggta attgaccaag cggcctaata tcttcaatac cattatcagc
     4081 agccgctact agggttaagt ttttatattt gctcaagaaa ctaatatctt tgagattgtt
     4141 ttgtgaaata tcaatgcctt ctaactgtgg catattatcc aaaaatctat aatcagtcac
     4201 ccctgttttt gtcattaaca actgtttcaa ttttttaaat tgcaaaacag gtgagatatc
     4261 tttgattggt gtaaagccaa gtcctaaagt ttctaagttg ggtaacagtg aaagtccttt
     4321 acattgcaaa ggatctttac ggctgcccaa gtcaagtttg ataaccgttg ctaaccagtc
     4381 tttcatctta ttcggatctt tttcatttga tgggaatggg gttggagcat catgagtgcg
     4441 aacgatatcc aaaatcactt cttcatcaaa ccctaaggca cgcaaggtat ccattccaac
     4501 cttatgtttt tccaattcac gggcatgctc aatagcatgt ggatctggaa tgtcttttcc
     4561 gatttcaata tcagataaca tcaatacgtg tgcgtggtca tggtgagggt attccaaacc
     4621 aagtttaccg tcttgtgttt ccacacgttt aatagttgat ggatcaatcc ccaatttttc
     4681 tgccaaataa gctaattttt cttggtattc cttttcacgt tcagatagct ctggtgtgtg
     4741 atgggtttct gctggctttt ctgctttttt agcgggatcg tattgatctg ccacatgtgc
     4801 ccagccaccc tgacgaaggt ccgcaaaaga aataggatgt aagtgaccat cgtggtccac
     4861 taaaatactg tcttttgtta ccccaacaat accttgaccg ttaaattgaa aaccatctga
     4921 ggttgggaaa tgcaagcctg gaataccatt agctgtagct gttgaaacag ggctactggt
     4981 ttgtgccaag cgagtagcaa cctgtttagc ttgtgcctgt gtctgacctg ataagcttga
     5041 cttcaaaata taatggaagt gatcatcgtg gcgaatcgtg tagtctaaag catcttcagc
     5101 cacaatatcc gctgggttaa attcataatg gtgatgagga tctgctactt tagaagtccc
     5161 ttgactagct gcttgctgag caacagctgg cttagctaaa cttgctcctt ttggaataag
     5221 gtattcaaat agacttccct ttaaatcggc ataaaaaata aaatgcgaat gaccatcatg
     5281 gtcaacaacg attccctgat ctgtttttga taagattttt gagtctttgg ttaaaataaa
     5341 cccatcatct gtaggaaaat cgacacccgc cacacctttg tgagtcttgt ttgtcttttt
     5401 gcttttttta atcggtttaa ttttgtttga cgtcattccc ttacgtgatt gtttcgtttt
     5461 aatgggatat gtaccattac ctcgtgattg acaagctatc aaagtcaact gagatgataa
     5521 caatagacca actaaaataa taactttttt cgttttcatt caaccctcct ttttatttaa
     5581 ccagttaagt atatcgcatc acttgttttt cctcaagctc tttttaggat aactattaat
     5641 tgttgacgag ttggagctct gaagcttcaa caaacaatag tttctgttgt tagtagcatt
     5701 acacaaaaaa ctaacttttc ttttcctttg aaaataagat cttttataat atactataca
     5761 tatgaaaaca tcagaaaaaa tttatcaatt actgtcacaa accgatgact tcgtcagtgg
     5821 ggaatatcta gcagatcaac tcagtatctc tcgtacatcc gtttggaaat ccatcaaaag
     5881 tctcgaaaat caggggattc aaattgattc tttaaaacac aagggctacc gcatggtaca
     5941 aggtgatatt ttattaccca aaaccattag ccaagggctt gggatgccag tcacctatac
     6001 ccctcatagc caatctaccc aattagatgc caaacaagga atcgaagctc ataacagcgc
     6061 tccaaggctt tacctagctc ctagccaaga agctgccaaa ggacgcctcg atcggcaatt
     6121 tttttcagct agcaccggtg gtatttacat gtccatgtac ctaaaaccca atgtccctta
     6181 tactgatatg cctccttata cgatgatggt tgcttccagt attgtcaaag ctatctcgcg
     6241 attaacaggc attgatacag aaatcaaatg ggtaaacgac atctatctag gtaaccataa
     6301 agttgcaggg attctgacag aagccattac ttctgttgaa actggtttaa tcaccgatgt
     6361 cattattggg gttggtctca acttttttgt caccgacttc ccagaagcga ttgctcaaaa
     6421 ggcaggttct ctctttaccg aaaaaccgac tatcacgcgc aatgacctta tcattgacat
     6481 ctggaaatta ttcttatcta ttcctgtcaa ggaccatgtc aaagtttaca aagaaaaatc
     6541 acttgttctt aataaacaag tgacctttat agaaaatagt caagaaaaac gtgctattgc
     6601 gattgatctc acagatcaag gacacctcat tgtacagttt gaaaatggtg accttcaaac
     6661 cttgcgaagc ggtgaaatca gtctttcttc ttgggagaat tagccgtttt taaaatggtt
     6721 ttagtcagtt ggttaatggt atgcactctt cttaaatccc taaagagcaa caagccccaa
     6781 aataaggcga agagataatt tccagagagc aacaggtcat taaaaaaata ggtttcaaag
     6841 gcacatacaa aggccataaa aagaaattgt cgaatagtca tagctttatt ataacaaaaa
     6901 aatactgtac tatgaagaaa agtaacgaga taaaacgtgg gtaagggcaa aaccttaccc
     6961 ttatgtattt cagttttagt cgtcaatagt atttatttta tcgagcaaaa aatcaaaccc
     7021 ttctggaata tcaagcgcta cttcttgttc ttcttgaaca ctgtcttttt gcgatttcat
     7081 ttgctgagca aattccttac gaatatgctg aaaatctgtc cttggtactg ccagaatatt
     7141 gggagaaaaa ccagcagctt tactcataat gttaccaaac atatcattaa gattatttcg
     7201 gctcatgact tgttctgcat taaaggcagc ctcgaaagcc aaaatcgcat tctcactatt
     7261 tgctaagaca ggctcagagc ccatcaataa ggctctgtct tgggcagaaa tgttatctag
     7321 aatttcattc caagcatttt ttagagcatc tagatattgt cgagattgtt ggctatttcg
     7381 aaccgtttct tccatgattt tcaaaatggt aacccgatca accctgtagc ttgtggtttt
     7441 agatttagtt ttatcagatc ttgccagtga atcaggacgc gattggagct gcgacaattg
     7501 ttgtttaagt tgtgccaact catttttgag cgtttcaatc tctgagatta actctcctga
     7561 caagtttgct tgggacaaaa tctgctcttt ctgagctaat tggatggtca tcatttcggc
     7621 ataaatccga ggatgggttc cctttttgat ttcagggaga tgactagtaa caactgttat
     7681 catttggaat atacgatcta tcgagagaga caaattagta tcaaaaacag ctgactgacg
     7741 ctgattgtcg ccgccagctt taaccaccaa taaatcacgc agataggtca ataaatctgt
     7801 cgcaaagcgg ctcatgctct tcccactatc ataaatggtc tctaaggctg ccagagcttg
     7861 cgtagcctgt tcttgggaga catatcgaac atagtcacct agagcaagta tggaaataga
     7921 acctgtaatt tcttcggcaa ttgcaatggt gacctgatta tctggtgaca agctcaaagc
     7981 ctgatctaaa atagataaag catcacgcat gcctccttct gctcgccttg caatgagatt
     8041 taaagcatcc acctcatagg caataccttc tttgtccaaa acccaggcta aatgctctcg
     8101 aatagctttt tgcttaatag ctttgaattc aaagcgttgc acacgagata aaatagtggc
     8161 tggaatttta tgcaattccg ttgttgccaa gataaagaca acattttctg tcggttcttc
     8221 caaagttttc aaaagcgcat taaaagcccc tgttgataac atgtgaacct catcaataat
     8281 ataaaccttg taagtcgcac gactcggcgc ataggttgat ttgtctcgaa tgtcacgaat
     8341 ttcatcaaca ccattattcg aggcagcatc aatttcaatc acatcttcca agcttccatt
     8401 cgtgatatct cggcaaatat cgcattgatt acagggttca ccatcgactt ggttaggaca
     8461 attcatggcc tttgcaaaaa tctttgccgc acttgttttc ccagtccctc taggacctga
     8521 aaaaagataa gcatggctaa tcttgccaga ttcaactgcc tgctttaaag ttgtggaaat
     8581 aaccgattgt cccaccattt cgtcaaacgt ttggctccgg tatttccgat aaagagcttg
     8641 atacatcagt ttttaactcc aaacatgtta aaggtaaacg tggtcttttc aagaagtagg
     8701 tccacaaagg tctctaagta ttcttgatca acctcatcat aatcagctac aagactagaa
     8761 tccaaatcca gcaccccaat caaatggcct tctttcacca taggcacaac aatttcactc
     8821 atggctgccg catcacagga aatatagttg gcatgctgct tcacatcatt tataataatg
     8881 gttcgacgag actgagctga ttcgccacaa acacctttac caagcttgat atggacgcaa
     8941 gaaaccctac cttgaaaagg gccaagaatt aattcctgcc catcaaaaag gtaaaatccc
     9001 gtaaaaacag aattgggtag tgtcatgttt aacagggcgc tggcatttga caaattagcc
     9061 aaagcatttg attcattcgc aaatagctct tttgcctgcg ctatcattag ttggtattgc
     9121 tcaatttttt tagacttatt catacctttt attatagcat atctgggtct attcgagtat
     9181 tttttacgac tatctttcgc ttcagtcagt ttttaaaatg gtttttgagg ttgtttatga
     9241 tataattttc aatattatta atatcatctt aatattagga ggttttcgtg aaacaaatca
     9301 ctcaacagaa atggttacga tacggtcttt ttattgcttt agttttaaat ggtattgaac
     9361 ttgaattgtt aggactgact gctaacaacc tttcctttaa agaagctttt gctctaatac
     9421 taaccattag tctattaggc atttacttaa ttccatttgc agcagctatt ttttatttaa
     9481 gtaaaaaatt tcatatgaac ctgaacgtta ttattgttag ctgtcttagc ggactttata
     9541 tttcaggttt tttagcttct tgtgggaacc atctcgtagg acaattttgg tcatacatca
     9601 tcccttctaa agacgcttta aagctttggg gagatgcttt aactgcccct attgtcgaag
     9661 agcccattaa ggcttcttcg gctattttag taattacttt atttcctaga cttactctta
     9721 aagaaaaatt agttgttgct ttactttctg gcatgggctt tcaactaaca gaagatatcc
     9781 gttatttgat tcaagcaaaa tctatagata gtctcgtacc gactgctatt gaacgtatta
     9841 gcactgctgt gacttcacat tgggtacata cagctatttt taccattgga gcatacttat
     9901 tattaaaggg ttctaacctt ttttcaaaac agcaacaaat attctggtta ttaagtcctc
     9961 tggttctaca tttcatctgg aactctcctc taacaagcat tcctggtatg acagttttac
    10021 taggaacatt aatcctttta atctttggtg atctttttca aaaaatcaac acccttgacg
    10081 atgatgtgct tttttaaact ataaaagagc cctgactaaa taatactgat taagggtctt
    10141 ttaagtgact cacttcataa agatataagt tactagtaat gtcaacaaaa tactagtata
    10201 ccaagtgatg acaaagtacc actttctggt tttatggtgg tactttttag ctgcaagtaa
    10261 tgctccaaaa cctccaaaca aaactgttat cactaataag tttctttcac taatacgccg
    10321 tttctttttt atggcttttc ttttatcaaa ggcatatatg acaaacacga gttcattcca
    10381 aacaaatagt aatccaagcc aaattaataa catttctatt ttatgatccc tttctctagg
    10441 aagagcacaa caataaaaga gcagatttaa ataatctact cagccacttc tactatactt
    10501 ctccaagaat actcgcaatt ttactattaa taacatcaat agcaacgaca ttactaactc
    10561 cctctggaat aacaatatca gcatagcgtt tacttggctc aataaactga tgatacatag
    10621 gctttaccac gcttgtgtac tgatcaataa tactttctaa gcttctgcca cgttccatca
    10681 tgtcacgctt aatacgacga ataatacgaa tatcgtcatc tgtgtctaca aagagcttga
    10741 tatccatcaa atctcgcaaa cgctcatctt ctaggacaag aataccttca acaataataa
    10801 catcctgagg atcctgacga aaggtcgtat tactgcgggt atgctttttg taatcataga
    10861 taggaatatc tacaggtcta ccagctaata attcttttag ttgctgaatc ataaaatctg
    10921 tatcaaaagc tagaggatgg tcataattgg ttttgaccct ttcttcaaaa ctcatgtgag
    10981 actgatcttt atagtaagaa tcgtgttgaa tcatcgcaat acgagcattt ggaaaactgt
    11041 ccaaaatagc gcgtgacaca cttgttttac cgccacctga accaccagtt acaccaataa
    11101 taatcggttt tttaagcatt ttaaactcca aatctaaaaa gtctttctca ctattttacc
    11161 aaaattgaga ctataatgct ataatgaata tagaaacaat agtaaaagga agacgcatga
    11221 tcactaaatt tccccctcaa tggcaagaaa aacttgacca agttgcattt acccatttaa
    11281 cgccaatcca agaacaggcc tttcaaccta ttgttgatgg taaaaatttc cttggtatta
    11341 gccctactgg gacgggcaag accttagctt atgtctttcc tagtctattg gcactgacgc
    11401 ctaaaaagtc ccaacaacta ctcattttag cccctaatac cgaattagct ggccaaattt
    11461 ttgaagtcac aaaggattgg gcacagccac taggcttaac ggcacaactc tttatttctg
    11521 gaaccagtca aaaacgtcaa atcgaacgcc tcaaaaaagg tcctgaaatc ctgattggaa
    11581 cccctggacg catttttgaa ctgattaaat tgaaaaaaat caagatgatg tctgtcaaca
    11641 ccattgtttt agatgaatat gacgaattat taggtgattc ccaatatgat tttgttcaaa
    11701 aaattagcca ctatgttcct cgagatcatc aaatggtata catgagtgct actaataagg
    11761 tggatcaaac ttccttagct ccaaatacat tctgcatcga tctttcagag caaaccaacg
    11821 atgctattca gcatttttac ctcatggttg acaagcgcga acgtacagat ttattacgaa
    11881 aatttgctaa tattcctcat tttagagctt tggtcttttt caacagttta tctgatttgg
    11941 gtgctacgga agaacgtctc cagtataatg gagctgctgc ggtttcctta gcgagtgaca
    12001 ttaatgtcaa attccgtaaa accattctcg aaaaattcaa atcccaccaa ctttccttat
    12061 tgttagctac ggatcttgtt gctcggggca ttgatattga taatcttgac tatgtcattc
    12121 attttgatgt tgctcgtgat aaggaaaatt acactcacag agctggacga accggccgta
    12181 tgggaaaatc tggtatcgtt attacctttg ttagccaccc tgaagacctc aaaaaattga
    12241 aaaaatttgc taaagtctct gaaatctccc tcaaaaatca acaacttcat ttcatcaact
    12301 agttgttaaa aaacaaaact taatcaaggg ctactaaaaa acaacaatcc aattacttca
    12361 aaagtaattg gattg
//
LOCUS       DAUDWO010000050        10834 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.051, whole genome shotgun sequence.
ACCESSION   DAUDWO010000050 DAUDWO010000000
VERSION     DAUDWO010000050.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10834)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10834)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10834
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.051"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            63..1877
                     /gene="dnaG"
                     /locus_tag="VHC05_001551"
     CDS             63..1877
                     /gene="dnaG"
                     /locus_tag="VHC05_001551"
                     /EC_number="2.7.7.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HEQ5402841.1"
                     /translation="MGLLWGGDDLAIDKEMISQVKNSVNIVDVIGEVVKLSRSGRHYL
                     GLCPFHKEKTPSFNVVEDRQFFHCFGCGKSGDVFKFIEEYRQVPFLESVQIIADKTGM
                     SLNIPPSQAVLASQHKHPNHALMTLHEDAAKFYHAVLMTTTIGQEARKYLYQRGLDDQ
                     LIEHFNIGLAPDESDYLYQALSKKYEEGQLVASGLFNLSDQSNTIYDAFRNRIMFPLS
                     DDRGHIIAFSGRIWTAADTEKRQAKYKNSRGTVLFNKSYELYHLDKARPVIAKTHEVF
                     LMEGFMDVIAAYRSGYENAVASMGTALTQEHVNHLKQVTKKVVLIYDGDDAGQHAIAK
                     SLELLKDFVVEIVRIPNKMDPDEFVQRHSPEAFADLLKQSRISSVEFFIDYLKPTNVD
                     NLQSQIVYVEKMAPLIAQSPSITAQHSYINKIADLLPNFDYFQVEQSVNALRIQDRQK
                     RQGQIAQAVSNLVTLPMPKSLTAIAKTESHLMHRLLHHDYLLNEFRHRDDFYFDTSTL
                     ELLYQRLKQQGHITSYDLSEMSEEVNRAYYNVLEENLPKEVALGEIDDILSKRAKLLA
                     ERDLHKQGKKVRESSNKGDHQAALEVLEHFIAQKRKME"
     gene            1886..2995
                     /gene="rpoD"
                     /locus_tag="VHC05_001552"
     CDS             1886..2995
                     /gene="rpoD"
                     /locus_tag="VHC05_001552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012515467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HEQ5402842.1"
                     /translation="MTKQKEITTFNVQVAEFIRHHKKEGTAIDDDVTEKLVIPFALDA
                     DQIDDLLERLTDGGISITDKEGNPSSKYIVEEPKPEELTDEELIGSNSAKVNDPVRMY
                     LKEIGVVPLLTSEEEKELAVAVAKGDLMAKQRLAEANLRLVVSIAKRYVGRGMQFLDL
                     IQEGNMGLMKAVDKFDYSKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINK
                     LVREQRNLLQELGQDPTPEQIAERMEMTPDKVREILKIAQEPVSLETPIGEEDDSHLG
                     DFIEDEVIENPVDYTTRVVLREQLDEVLDTLTDREENVLRLRFGLDDGKMRTLEDVGK
                     VFNVTRERIRQIEAKALRKLRHPSRSKQLRDFIED"
     gene            3231..3569
                     /locus_tag="VHC05_001553"
     CDS             3231..3569
                     /locus_tag="VHC05_001553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HEQ5402843.1"
                     /translation="MSDTPKYTQDQVIAIKNRILEALETVIDPELGIDVVNLGLIYEI
                     RFNDNGYTEIDMTLTTMGCPLADLLTDYIHDALQDVPEVTKTEVKLVWYPAWTVDKMS
                     RYARIALGIR"
     gene            3707..4561
                     /gene="rfbD"
                     /locus_tag="VHC05_001554"
     CDS             3707..4561
                     /gene="rfbD"
                     /locus_tag="VHC05_001554"
                     /EC_number="1.1.1.133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="HEQ5402844.1"
                     /translation="MILITGSNGQLGTELRYLLDERGVDYVAVDVAEMDITNEDKVEA
                     VFAQVKPTLVYHCAAYTAVDAAEDEGKALNEAINVTGSENIAKACGKYGATLVYISTD
                     YVFDGNKPVGQEWVETDCPDPKTEYGRTKRLGELAVERYAEHFYIIRTAWVFGNYGKN
                     FVFTMEQLAENHSRLTVVNDQHGRPTWTRTLAEFMCYLTENQKAFGYYHLSNDAKEDT
                     TWYDFAKEILKDKAVEVVPVDSSAFPAKAKRPLNSTMNLDKAKATGFVIPTWQEALKA
                     FYQQGLKK"
     gene            4680..5834
                     /locus_tag="VHC05_001555"
     CDS             4680..5834
                     /locus_tag="VHC05_001555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1972 domain-containing protein"
                     /protein_id="HEQ5402845.1"
                     /translation="MQDVFIIGSRGLPAKYGGFETFVEELISHQSSKNIRYHVACLSD
                     TKHKVHFDYKGADCFYLNPPKLGPARVIAYDMMAITYALSYSDQNQIQNPIFYVLGNT
                     VGAFIAPFVKQIHNRGGRFFINPDGLEWKRSKWSRPVQAYLKFSEKQMTRQADLVISD
                     NIGIDRYLKQVYPWSKTYFIAYGTQTQPSRLTTADSKVRAYFQTFDIREKDYYLILGR
                     FVPENNYETAIKEFMASSTKRDLVIICNHEGNAYFKQLLAETECDKDPRIKFVGTLYD
                     KELLAYIREQAYAYIHGHEVGGTNPGLLEALAHTNLNLVLGVDFNQSVAKSAALYWSK
                     QKGQLAELINQVDAGFDSDHLGKEAKAIIQEHYTWEKIVGEYEALFLNEH"
     gene            5824..6756
                     /locus_tag="VHC05_001556"
     CDS             5824..6756
                     /locus_tag="VHC05_001556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEQ5402846.1"
                     /translation="MNINILLSTYNGERFLAEQIQSIQRQTVNDWTLLIRDDGSTDGT
                     QDIIRTFVKEDKRIQWINEGQTENLGVIKNFYTLLKHQKADVYFFSDQDDIWLDNKLE
                     VTLLEAQKHEMTAPLLVYTDLKVVTQHLAICHDSMIKTQSGHANTSLLQELTENTVTG
                     GTMMITHALAEEWTTCDGLLMHDWYLALLASATGKLVYLDIPTELYRQHDANVLGART
                     WSKRMKNWLNPHHLVNKYWWLITSSQKQAQLLLDLPLKPNDHELVTAYVSLLDMPFTK
                     RLATLKRYGFRKNRIFHTFIFRSLVVTLFGYRRK"
     gene            6759..7562
                     /locus_tag="VHC05_001557"
     CDS             6759..7562
                     /locus_tag="VHC05_001557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402847.1"
                     /translation="MNFLTKKNRILLREMVKTDFKLRYQGSAIGYLWSILKPLMMFTI
                     MYLVFIRFLRLGGNIPHFPVALLLANVIWSFFSEATSMGMVSIVSRGDLLRKLNFSKH
                     IIVFSAVLGALINFLINLVVVLIFALINGVTISGYAYLSLFLFIELVVLVLGIALLLS
                     NVFVYYRDLAQVWEVLLQAGMYATPIIYPITFVLDSHPLAAKLLMLNPVAQMIQDFRY
                     LLIDRANVTIWQMSTNWFYIVIPYLVPFVILFIGIFVFKKNADRFAEII"
     gene            7562..8767
                     /locus_tag="VHC05_001558"
     CDS             7562..8767
                     /locus_tag="VHC05_001558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402848.1"
                     /translation="MINREIAVKVQHVSKTFKLPTEATKSFRTTLVNRLRGIKGFTEQ
                     HVLKDINFDVYKGDFFGIVGRNGSGKSTLLKIISQIYVPEKGQVTVDGKMVSFIELGV
                     GFNPELTGRENVYMNGAMLGFTKDEVDDMYNDIVDFAELHHFMNQKLKNYSSGMQVRL
                     AFSVAIKAQGDVLILDEVLAVGDEAFQRKCNDYFMERKDSGKTTILVTHDMGAVKKYC
                     NRAVLIEDGLVKAYGEPFDVANQYSVDNTETAEDAMNAEKISVSDIAKDLKVSLISNP
                     RITPNDTITFEVSYEVLKDDFTYIAFSLTDIDRNIWVYNDNSLDYPTQGIGRKCISYQ
                     CQLSQLNDIKLKLEVTVRDKNGQMLLFSTAEQSPQIVIQRNDIDQDDLSALDSASGLY
                     QRNGKWVFH"
     gene            8792..9799
                     /locus_tag="VHC05_001559"
     CDS             8792..9799
                     /locus_tag="VHC05_001559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HEQ5402849.1"
                     /translation="MYKVSIICTNYNKAPWISDALDSFLSQVTDFEVEIIVIDDASTD
                     DSREILKSYQKKSSGKIKLLFNETNIGITKTWIKACLYAKGKYIARCDGDDYWTDSFK
                     LQKQVDVLEASKRSRWCNTDFDFVNSQGDLLYANAFSSGHTPLTDTYEKVLALKGMTM
                     ASTWLVDADLMRQVNQKINVDTPDDTFDIQLELFQLTQLTYIKDSTTVYRMTTDSDSR
                     PTDTPKMIHRIQKLLDTQLNYLKKYNQVDTKEVSKLLLQQDAKQEIRIHELSCFIQEL
                     QQTIVDKTKQQETREVELQNVIEEQKNQLSELRQQYHAIINSRQWKYTSKLIAFIRRK
                     K"
     gene            9796..>10834
                     /locus_tag="VHC05_001560"
     CDS             9796..>10834
                     /locus_tag="VHC05_001560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-L-Rha alpha-1,3-L-rhamnosyltransferase"
                     /protein_id="HEQ5402850.1"
                     /translation="MNRILLYVHFNKYNKISAHVYYQLEQMRSLFSKIVFISNSKVSH
                     EDLKRLKNHCLIDEFLQRKNKGFDFSAWHDGLITMGFDKLEEFDSLTIMNDTCFGPIW
                     EMAPYFENFEEKETVDFWGITNNRGTKAFKEHVQSYFMTFKNQVIQNKVFQQFWQSII
                     EYENVQEVIQHYETQLTSILLNEGFSYQTVFDTRKAESSFMPHPDFSYYNPTAILKHH
                     VPFIKVKAIDANQHIAPYLLNLIRETTNYPIDLIVSHMSQISLPDAKYLLSQKYLNCQ
                     RLAKKTCQKVAVHLHVFYVDLLDEFLTAFEDWNFHYDLFITTDSDIKRKEIKEILQRK
                     GKTADIRVTGNR"
BASE COUNT         3570 a         1807 c         2155 g         3302 t
ORIGIN      
        1 tcacttcagt ttttaaattt acaaaaaaga gtttcggtgg tataataaaa cgtaaaacta
       61 aaatgggatt gttatgggga ggtgacgatt tggcaattga caaagaaatg atttcccaag
      121 taaaaaatag cgttaatatt gtcgatgtca ttggagaagt ggtcaaactt tcccgatcag
      181 ggcggcatta tctcgggctt tgcccatttc ataaggaaaa gacaccctct tttaatgttg
      241 ttgaagacag acaatttttt cactgctttg gctgtggaaa atcaggggat gtttttaaat
      301 ttattgagga ataccgccaa gtccccttct tagaaagtgt tcagattatt gccgataaga
      361 ctggtatgtc gcttaatatc ccgccaagtc aggcagtact tgctagccaa cacaagcacc
      421 ctaatcacgc tttgatgaca cttcatgagg atgctgctaa attttaccat gcagttttga
      481 tgaccactac cattggtcaa gaagctagga agtaccttta ccagagaggt ttggatgacc
      541 aattaattga gcatttcaat attggtttag ccccagatga gtcagattat ctttatcaag
      601 ctctttctaa aaaatacgag gaaggtcaat tggttgcttc aggattgttt aacttgtccg
      661 atcaatctaa taccatttac gacgcctttc gaaatcgtat catgtttccc ttatcagatg
      721 accgagggca tattattgcc ttttcaggac gtatctggac ggcagctgat acagaaaaga
      781 gacaggccaa gtataaaaat tcaagaggaa cagttctttt taacaaatct tatgaattgt
      841 atcatctgga caaggcaagg cctgttattg ccaaaaccca tgaagtattt ctaatggaag
      901 ggtttatgga cgtgattgcc gcttaccgtt ccggctatga aaatgctgtt gcttcaatgg
      961 ggacggcatt gactcaagaa catgtcaatc accttaagca agtcactaaa aaagttgttt
     1021 tgatttatga tggtgacgat gctggacaac atgctattgc aaaatcacta gaattgctta
     1081 aagattttgt tgtcgaaatt gtcagaatcc ccaataaaat ggatcctgac gaatttgtac
     1141 aacggcattc cccagaagca tttgcagatt tgcttaagca gtcacggatc agtagtgttg
     1201 aattttttat tgattaccta aaacctacta atgtagacaa tttgcaatca caaattgttt
     1261 atgtggagaa aatggcacca ttgattgctc aatcaccatc catcacagct caacattcgt
     1321 atattaacaa gattgctgat ttgttgccaa actttgacta ttttcaagta gaacaatcag
     1381 taaatgcatt aaggattcaa gataggcaaa agcgtcaagg tcaaatagct caagctgtca
     1441 gcaatcttgt gaccttacca atgccaaaaa gtttgacagc tattgctaag acagaaagtc
     1501 atctcatgca tcggctctta catcatgact atttattaaa tgaatttcga catcgtgatg
     1561 atttttattt tgatacctct accttagaat tactttatca acggctgaag caacaaggac
     1621 acattacatc ttatgatttg tcagagatgt cggaggaagt taaccgtgct tattataatg
     1681 ttttagaaga aaaccttccc aaagaagtag ctcttggtga gattgatgat attttatcca
     1741 aacgtgccaa acttttagca gagcgcgatc ttcacaaaca agggaaaaaa gttagagaat
     1801 ctagtaataa aggcgatcat caagcggctc tagaagtact agaacatttt attgcgcaga
     1861 aacgaaaaat ggaatagagg aaattatgac aaaacaaaaa gaaataacaa cttttaacgt
     1921 tcaagttgcg gagtttattc gccatcacaa aaaagaagga acagcgattg atgatgacgt
     1981 gaccgaaaaa cttgtcattc catttgcttt ggatgctgat cagattgatg acttacttga
     2041 gcggttaaca gatggtggta tctcgattac ggataaagaa ggtaacccat catcaaaata
     2101 cattgttgaa gaaccaaaac cagaagaatt aactgatgaa gaattaattg gtagtaattc
     2161 agctaaagta aacgaccctg tccgcatgta cctcaaagaa attggtgtgg taccgctttt
     2221 aacaagtgaa gaggaaaaag aattggctgt tgcggttgcc aagggagatt taatggctaa
     2281 acaacgttta gcggaagcaa accttcgtct tgttgtctca attgcaaaac gttatgttgg
     2341 acgtggaatg caatttcttg atttaattca agaaggtaac atgggactca tgaaagctgt
     2401 tgataaattt gattattcaa aaggattcaa attctcaact tatgcaacat ggtggattcg
     2461 tcaagctata acacgcgcaa ttgcagatca agcacgtacg attcgtatcc ctgttcatat
     2521 ggttgaaacg attaataaat tagtccgtga acaacgtaat cttcttcaag aacttggtca
     2581 agatccaacg ccagaacaaa tcgcagaacg tatggaaatg actccagaca aggttcgtga
     2641 aattctaaaa attgctcaag aacctgtttc tttagaaaca ccaattgggg aagaagatga
     2701 tagtcactta ggtgatttta tcgaagatga agttattgaa aatccagtag attatacgac
     2761 gcgtgttgtt cttcgtgagc aattggatga agttttagat acgcttactg accgtgaaga
     2821 gaacgttctt cgcctacgct ttggccttga cgatggtaaa atgcgtacgt tagaggacgt
     2881 aggtaaagtc tttaatgtta ctcgtgagcg cattcgacag attgaagcta aagcccttag
     2941 aaaacttcgc catcctagtc gtagtaaaca attaagagac tttatagagg actaaaatcg
     3001 tccagtggac gattttaggt cgttcctttg aaataagaaa ggagcgaaaa tcccaagtgg
     3061 cacttatcag cggtacacct acaaattaga aaacggaccg aatgtggtgg gtatttttaa
     3121 gggtagactt gatatcttaa acaagcccag agggcaattc ctctaaatag gcaaagcttt
     3181 agtggttttt ttacttatct acgatatatt caaaaaatga aaggaaagcc atgtctgata
     3241 caccaaaata tacacaagat caggtgatag ctatcaagaa tagaattctt gaagctttag
     3301 aaactgttat tgatcccgag ctaggtattg atgttgttaa tctaggcttg atttatgaaa
     3361 ttcggtttaa tgataacggt tatacagaga ttgatatgac actcacaaca atgggttgtc
     3421 ctttggcaga cttgttgaca gattacatcc atgatgccct gcaagatgtg ccagaagtca
     3481 ctaagactga ggtcaaatta gtctggtacc ctgcttggac ggttgataaa atgagccgct
     3541 atgctaggat tgcgctgggt attcgctaat cattgatagt aaagggatga aatattccct
     3601 tttttgatgt agaataaaag gaaatacagg tgaaagcctt tggttaatgt tagagaacac
     3661 taagatactg agaaaagtgt tctacctatg gcaaaaagga gaactgatga ttttaattac
     3721 aggaagcaat ggtcaattag ggacagaact tcgatactta ttagatgaac gaggtgttga
     3781 ttatgtagcc gttgatgtcg cagaaatgga catcacaaat gaagacaaag tcgaagctgt
     3841 ttttgcgcag gtcaagccaa cattggtcta tcattgtgct gcttatacgg cagttgatgc
     3901 agcagaagac gaaggaaaag ctttgaatga ggctattaat gtaacaggct cagaaaatat
     3961 tgccaaggct tgtggaaaat atggggctac ccttgtttac atttcaacag actacgtatt
     4021 tgatggcaat aaaccagtcg gtcaagaatg ggtagaaaca gattgtccag accctaagac
     4081 agaatatggc cgtacaaaac gtttaggaga actagctgtt gaacgatacg cagagcattt
     4141 ttatattatc cgtactgctt gggtatttgg aaattatggt aaaaactttg tctttaccat
     4201 ggagcagtta gcggaaaatc actcccgttt gactgttgtc aatgaccaac acggtcggcc
     4261 aacgtggaca agaaccttgg cagaattcat gtgttatttg acagagaatc aaaaagcctt
     4321 tggttactat cacttgtcaa atgatgctaa ggaagacacc acttggtatg attttgccaa
     4381 agaaatctta aaagacaagg ctgttgaagt ggtgccagtt gattcatcag ctttcccagc
     4441 aaaagccaaa cgtcctttaa attcaaccat gaatcttgat aaggcaaaag caacagggtt
     4501 tgttattcca acatggcaag aagccttgaa ggcattttac caacaaggac tgaaaaagta
     4561 agtattctaa aaagagttgg ctttctaagg ccaactcttt ttcatgggtt taaggtcgca
     4621 ttagccttct aattgtggta taatatcact gattatattt tagaatgggg tagtatgcaa
     4681 tgcaggatgt ttttatcatt ggtagcagag ggttaccagc gaaatacggt ggctttgaaa
     4741 cctttgtcga agagttgatt agtcatcaat catctaaaaa cattcgttat cacgttgctt
     4801 gtttaagcga tacgaagcat aaggttcatt ttgattataa gggggcagat tgcttttacc
     4861 ttaatccccc aaaacttggt cctgctagag ttattgctta tgatatgatg gcaattacct
     4921 atgccctgtc ttatagcgac caaaaccaga ttcagaaccc tattttttat gtgttgggca
     4981 atactgtagg cgcttttatt gcgccatttg tgaagcagat tcacaatcga ggtggacgct
     5041 tttttatcaa tccagacggg ttagagtgga aacggtctaa atggtcaaga ccagtgcagg
     5101 cctacctgaa gttttccgaa aagcaaatga ctagacaggc tgatttggtc atttcagata
     5161 atattggcat tgaccgctac cttaaacagg tttatccttg gtctaaaaca tattttattg
     5221 cttatggaac gcagacacaa ccttcacgtt tgacaacagc agatagcaag gtcagagctt
     5281 attttcaaac ctttgatatt agagaaaagg attactatct cattttagga cgctttgttc
     5341 ctgaaaataa ttacgaaact gctattaaag aatttatggc ttcctcaact aagcgtgatt
     5401 tagtgattat ttgtaatcat gaaggcaatg cttactttaa gcaattactt gctgagacag
     5461 agtgtgataa agacccacgc attaaatttg ttggtaccct ttatgataaa gaactattag
     5521 cctacattcg agaacaggct tatgcctata tccatggtca tgaggtagga gggactaatc
     5581 caggccttct agaagcacta gcccatacca atcttaattt ggttttagga gttgatttta
     5641 accagtcggt ggctaagtct gctgcgctgt attggtccaa gcaaaaaggg caattagcag
     5701 agctgattaa ccaagttgat gcaggttttg atagtgatca tctgggcaaa gaagccaaag
     5761 ctattattca agaacattac acttgggaaa aaattgtagg ggagtacgag gctttatttt
     5821 taaatgaaca ttaatatttt actatccacc tacaatggag aacgcttctt agcagaacaa
     5881 attcaaagta tccaaaggca aacagttaac gactggacct tattgattag agatgatgga
     5941 tcaactgatg gcacccagga tattattcgc acatttgtca aggaagacaa acgaattcag
     6001 tggatcaatg aggggcagac agaaaatctg ggagttatta agaattttta caccctctta
     6061 aagcaccaaa aagcagatgt ctattttttc agtgaccaag atgatatatg gttagacaat
     6121 aaactggaag tgaccttatt ggaggctcaa aaacatgaaa tgacagctcc tttattggtt
     6181 tatacagacc tcaaagtggt aacccaacat ttagctattt gccatgacag tatgattaag
     6241 acccaatctg gtcatgcaaa cacaagccta cttcaagaat taaccgaaaa taccgtaaca
     6301 ggcggcacaa tgatgattac tcatgctctg gctgaggaat ggaccacttg tgacggttta
     6361 ttgatgcatg actggtattt agctttacta gcttctgcta ctgggaaatt agtttacctt
     6421 gatattccaa cagaattata ccgtcagcac gatgctaacg tgttgggagc tagaacttgg
     6481 tctaaacgca tgaaaaattg gttaaacccc catcatttag tcaacaaata ttggtggttg
     6541 attacttcaa gccaaaaaca ggctcaatta ctattagatt taccattaaa accaaatgac
     6601 catgaattgg taacggccta tgtttcttta ttggatatgc cttttaccaa acgcttagct
     6661 accttgaaaa ggtacggttt tagaaaaaat cgcatctttc acacctttat ttttcgtagt
     6721 ttagttgtta ccttatttgg ttacaggaga aagtaagaat gaatttttta acaaagaaaa
     6781 accgtatttt actgagagaa atggtaaaaa cggattttaa attacgctat caagggagcg
     6841 caattggcta tctatggtct atcttaaaac cgcttatgat gtttacgatt atgtacttgg
     6901 tgtttattcg ttttcttcgc ctgggtggaa atatacctca ttttccagta gcgcttttat
     6961 tggcaaatgt catctggtct tttttttcag aagcaactag catgggaatg gtatctattg
     7021 tatctcgggg agacttgttg cgaaaattga acttttctaa gcacatcatt gttttttcgg
     7081 cagtgttagg agctttaatt aattttctta ttaatttggt tgttgtttta atttttgcgt
     7141 tgataaatgg tgtgactata tcagggtatg cttatctctc tctttttctt tttatagaat
     7201 tagttgtttt agtgcttgga attgcattgt tattgtcgaa tgtctttgtt tattatcgtg
     7261 acttagctca agtctgggaa gtactattac aagcaggtat gtatgccact ccaatcattt
     7321 atccgatcac ttttgtttta gatagccacc ctttggcggc aaagttgttg atgctaaatc
     7381 cagtagcaca aatgattcaa gattttcgtt atttattgat tgacagggcc aacgtaacga
     7441 tttggcagat gtcaaccaat tggttttaca ttgttattcc atatttagta ccatttgtta
     7501 tattatttat tggcatcttt gtctttaaga aaaatgccga tagatttgcg gagattattt
     7561 aatgattaat agagaaattg cagtaaaagt acagcatgtt agtaaaacat ttaaactgcc
     7621 tacagaagca actaaaagtt ttcgcacgac tctggttaat cgcctaagag ggattaaagg
     7681 atttactgaa caacatgtgc taaaagatat taactttgat gtttataaag gcgatttttt
     7741 tggaattgtt gggcgtaacg gctcaggaaa atcaacgctc cttaaaatta tttctcagat
     7801 ctatgttcca gaaaaagggc aggttacagt agatgggaag atggtttctt ttatagagct
     7861 tggagtggga ttcaatccag aattaacagg acgagaaaat gtctatatga acggcgccat
     7921 gctgggattt accaaagacg aagttgatga tatgtacaat gatattgttg attttgcaga
     7981 gttgcatcat tttatgaatc aaaaattaaa aaattattct tctggcatgc aggtacgttt
     8041 agcattttca gtggctatta aagcccaagg tgacgttctt attttagatg aggtgcttgc
     8101 tgtaggagat gaagcttttc agcgaaaatg taatgattat tttatggaaa gaaaagacag
     8161 tggtaagacg actattttag tgacacatga tatgggagct gttaagaagt attgtaaccg
     8221 tgcagttctt attgaagatg gtcttgttaa agcatatgga gaaccatttg atgttgctaa
     8281 tcagtatagt gtagataata cagagacagc tgaggatgca atgaatgctg aaaaaatatc
     8341 tgtatctgat attgccaaag atttgaaagt gtcattaatc tcaaatccaa gaataacacc
     8401 aaatgacaca atcacatttg aagtttctta tgaagtttta aaagatgatt ttacctacat
     8461 tgccttttct ttaacggata ttgatagaaa catttgggtt tacaacgaca attctttaga
     8521 ttatccaaca caaggtatag gtagaaaatg catttcttac caatgtcaac tatctcaact
     8581 taatgatata aaactaaaat tagaagtaac tgtccgagat aagaacggtc agatgctact
     8641 cttttcaaca gcagaacaat caccccagat agtgattcaa agaaacgata ttgatcaaga
     8701 tgatctgtca gctctagatt cagcaagtgg cttgtatcaa cgtaatggga agtgggtttt
     8761 tcattaatga gtaatagcta gaagggaatt tatgtataaa gtttcaatta tttgcaccaa
     8821 ttataacaaa gctccttgga tatctgatgc acttgacagt tttttaagcc aagtgacaga
     8881 ttttgaggtt gaaattattg ttattgatga tgcttctaca gatgactcac gagagatttt
     8941 aaagagttat caaaaaaagt cttcaggaaa aattaaatta ctctttaacg aaactaatat
     9001 tggaataaca aagacttgga taaaagcatg cctttatgca aaaggcaaat atattgctag
     9061 atgtgatggt gatgattact ggacggatag ttttaaactc caaaaacaag ttgatgtctt
     9121 agaagcttcc aaacggtcac gatggtgtaa tactgatttt gactttgtaa atagtcaagg
     9181 cgacttatta tatgctaatg ctttttcatc tggtcataca cctttgacag atacttacga
     9241 aaaagtttta gccttaaaag ggatgacgat ggcatcgaca tggctagttg atgctgattt
     9301 aatgagacaa gtaaaccaaa aaatcaatgt agatacacca gacgatactt ttgatattca
     9361 actagagtta tttcaactga ctcaactgac ctatattaaa gactccacga cggtttatcg
     9421 catgacaacc gattctgatt caagacctac tgatacacca aaaatgattc atcgtattca
     9481 aaaactactt gatactcagt taaattactt aaaaaagtat aatcaggtag atacaaaaga
     9541 agtgtctaaa ctattattac aacaagatgc taagcaagaa atacgaattc atgagttgag
     9601 ttgctttatt caagaattac aacaaactat cgtagataaa acaaagcagc aagaaacacg
     9661 tgaagtggag ttgcaaaatg tcatagaaga acaaaaaaat caactatctg aattaagaca
     9721 acaataccat gccattatta attcacgtca atggaaatac acgtctaagc tcattgcttt
     9781 tattaggaga aaaaaatgaa tcgtatttta ttatatgttc acttcaacaa atacaataaa
     9841 ataagtgcac atgtttacta tcaattggaa caaatgagat cactgttttc taagattgtt
     9901 tttatctcaa atagtaaagt gagtcacgaa gatttaaaac gtctcaaaaa ccactgtctt
     9961 attgatgagt ttttgcaacg caaaaataaa ggttttgatt tttctgcatg gcacgatggc
    10021 ttgattacta tgggatttga caagttggaa gagtttgact cattgacgat tatgaacgat
    10081 acttgttttg gtcctatttg ggagatggct ccttattttg aaaattttga agaaaaagag
    10141 acagttgact tttggggaat tactaataat agaggtacaa aagcttttaa agaacatgtc
    10201 caaagttatt ttatgacgtt taaaaatcaa gtcattcaaa acaaagtttt tcaacaattt
    10261 tggcaatcga taatagaata tgaaaacgtt caagaagtga ttcagcatta tgaaacgcaa
    10321 ttaacatcca ttctcttaaa tgaaggcttt agttatcaga cggtctttga tactagaaaa
    10381 gctgagtcgt cattcatgcc acatccggat ttttcatatt ataatccaac agcaattcta
    10441 aaacaccatg tgccttttat aaaagtaaaa gctattgatg ctaaccagca tatcgctcct
    10501 tacttactga atctgatacg agaaacaacc aattatccta tagatcttat tgtttcacat
    10561 atgtcgcaaa tctctttgcc agatgctaag taccttttat ctcaaaaata cctaaactgc
    10621 caacggttag caaaaaaaac ttgtcaaaag gtagctgttc atttacatgt tttttacgtt
    10681 gatttgctag atgaattttt aacagctttc gaagactgga acttccatta tgatcttttt
    10741 attacaacag atagtgatat caaaagaaaa gagatcaaag aaatacttca aagaaaaggt
    10801 aaaactgctg atatacgcgt tacgggaaat agag
//
LOCUS       DAUDWO010000051         9176 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.052, whole genome shotgun sequence.
ACCESSION   DAUDWO010000051 DAUDWO010000000
VERSION     DAUDWO010000051.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9176)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9176)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9176
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.052"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(264..1406)
                     /locus_tag="VHC05_001561"
     CDS             complement(264..1406)
                     /locus_tag="VHC05_001561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerate kinase"
                     /protein_id="HEQ5402851.1"
                     /translation="MTINRVLKDDNLLQYTEKEFIEDMKILVAIDSFKGSVTSPELNT
                     SVAQALLSVDKQLVIETRAIADGGEGSLAALSQTVAGRWHQVKTIDLLRRPIKVAYYR
                     HAKQAFIESASIIGIDKITPNSVSYAQATSYGLGLAVKDAIQKGATQIEIMLGGTGTS
                     DGGKGFLESLNYDFMTGRSYLDTLASPVTLLGPTDVTNPYHGPQGFAAVFGPQKGGSL
                     SQIEETDQIASNFAKKVFCQTTIDLQTIPGSGAAGGLGGAIVLLGGTLTSGFSRIAEL
                     LNLDNSLQSCDLVITGEGCLDTQSQSGKVPVAIARMAKKYQVPTIALCGSVKIETGLA
                     AEDFLAVFSIQQQPISLEAAIDKTTTLSNIKILAANLMLLIAQFNK"
     gene            1687..4665
                     /locus_tag="VHC05_001562"
     CDS             1687..4665
                     /locus_tag="VHC05_001562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I restriction endonuclease subunit R"
                     /protein_id="HEQ5402852.1"
                     /translation="MGNQTKTELELEKELIHLLETGESQWTYRKELKTEDALWDNFFK
                     ILAQNNTQYLNEEPLTASEKEQIKNQLNFVNYYEAAKWLAGENGIAKVQVQREDAKLG
                     TIRLEVVKADNVAGGTSVYEIANQVAFSGSRDRRGDVTLLINGLPMIQIELKSQNHQC
                     IEAFNQVKKYDKEGQFRGIFSTLQMFVVSNKTDTRYIAAAKENKLNPNFLTQWVDQNN
                     KPQKDLFAFAKEVLSIPRAHQMVMTYSVIDDDKKALILLRPYQIHAIEAVAEASRHRK
                     SGYIWHTTGSGKTLTSYKVARNILQIPAVEKSIFVIDRKDLDNQTTSAFQSYAQNDIF
                     DVDETEDTRQLIKNLESSDRRVVITTIQKLNAMISQMESYDTPKFKKLKERLAHLNVV
                     FVVDECHRAVTPERQRHLTNTFRNSRWYGFTGTPIFMENKRAQLGDLAQTTEQQYGKC
                     LHQYTVKEAIHDKAVLGFQVEYKTTIPDMPEDSIPEEAYDHEEHMLAVLNSIINQSRK
                     KLGFNNGIGQTFEGLLTVKSIARAQAYYDLIQKVKAGETDLVISKKVKEKLPDFPKVA
                     ITYSITENDNASISRQDKMTKNLEDYNHLFGTNFTIDNLQGYNRDLNDRLARKKDKFK
                     DRHEQLDLVIVVDRLLTGFDAPCLSTIFIDRQPMKPQHIIQAFSRTNRIFESRKHYGQ
                     VVTFQTPLRFKEAVDKALSLYSNGGENDVLAPSWEEEKARFFEKVTVLKNIVPDPDAF
                     PTIESAQTAFLKQYAKAFQAFDKLFASVQVYSDFNETLLSEVGLSDEVIDTYKGTYQN
                     VIAEIRKRREDDEAIPEINIDYELESVQMDDINYHYILTLIQAFVDQEQEALQERLND
                     NPMDQYIQDLAKSNPAMADSLAELWQDIQKESKAYEGKSIAYELDNLIGDKIQRAIKH
                     FADQWKADPDKLAFVATNYHSANSTKQVGMSTLKESLDYQAYKEKQGDSAMNKLKYKS
                     QFERELVQFIRDQIQPLKGH"
     gene            4678..5853
                     /locus_tag="VHC05_001563"
     CDS             4678..5853
                     /locus_tag="VHC05_001563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011527759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEQ5402853.1"
                     /translation="MTKSKQPQYRFDGFEGEWEEKELGDIVQITMGQSPSSQNYTTNP
                     SDYILVQGNADIKNGYVFPRVWTTQITKQADKGDIILSVRAPVGDVGKTNYHVIIGRG
                     VAAIKGNEFIFQILKYLKEIGYWKRISTGSTFDSISSSNIKYAKIQIPSLPEQEAIGE
                     LFQTVDQLIQLQDQKLATLKEQKQTFLRKMFPAQGQKVPEIRLQGFDGEWEEKKLGEI
                     SRMFSGGTPSVGISEYYNGNIPFIRSSEINSDQTELFITNKGLSNSSAKIVEKNTLLY
                     ALYGATSGEVGLSRISGAINQAILAIIPEKKYSSLFIKNWLYKQKSSIIEKYLQGGQG
                     NLSGSIVKGLELYLPSLPEQEAIGDFFQTLDQQMSQIEDKLTELKALKQTLLNRLFV"
     gene            5866..7446
                     /locus_tag="VHC05_001564"
     CDS             5866..7446
                     /locus_tag="VHC05_001564"
                     /EC_number="2.1.1.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I restriction-modification system subunit
                     M"
                     /protein_id="HEQ5402854.1"
                     /translation="MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDK
                     LLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDLISVVTGDLGYFIEPTLTFEKLI
                     QDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKT
                     LNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQK
                     GMTLYDPAMGSGSLLLNAKKYSNQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQH
                     LSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADF
                     AFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNT
                     SIPTTIIILKKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDAYKSRDNSDKFS
                     YLASFDEIIENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKTNAKLDQLMK
                     QLVGTTKEAQDELDTFRN"
     gene            complement(8003..8608)
                     /locus_tag="VHC05_001565"
     CDS             complement(8003..8608)
                     /locus_tag="VHC05_001565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5402855.1"
                     /translation="MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLS
                     KYDIILLDINLTNISKENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAYGF
                     VDKNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSKKGFSIKEIEE
                     TLQISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMDF"
     gene            complement(8589..>9176)
                     /locus_tag="VHC05_001566"
     CDS             complement(8589..>9176)
                     /locus_tag="VHC05_001566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402856.1"
                     /translation="VEFSNYLHDDVLQNIIAIKNLLSLENSNITHGFIVNELNDLVSG
                     IREEIDTYHPIVPANQTMKENIQSLFDDIVKSRKSNTLLYFNCSDNMVVPSPYGDIVY
                     RFIKELINNAIKYGDGKDIRLSLTIQSDIIIIEESNQVVEKVHSISYGRGLKSFQETL
                     AAFDGDLELQMDTKQFTIRILLPIDWKLCYEDFIN"
BASE COUNT         3062 a         1755 c         1557 g         2802 t
ORIGIN      
        1 acgtctccta agagacaact tctttattct atcaggtttc tcatagcctg tcaactactt
       61 tttcatcttt tttcaataag tgtgttacag gaacctctct gacagcttta ttagtatacg
      121 atatctttac tgtcattgtc aactcttttt tacaaaatgt ttctgttttt catactatgc
      181 taatgagtta gctcgtgcgt ctccttcttc ataggttact tttaaccgcc aaatgaatgc
      241 tacacaatcg aaaatagatg agtttactta ttaaactgag ctatcaatag cataaggtta
      301 gctgctaata ttttgatatt agaaagtgtt gttgttttat ctatcgctgc ttctaaggaa
      361 attggctgct gttgtattga aaaaacagcc aaaaagtctt ctgctgctag tcctgtctca
      421 atctttacag aaccacatag agcaatcgtt ggaacttgat attttttagc cattcttgca
      481 atcgcaacag gtaccttgcc agattgtgat tgtgtatcca ggcatccttc tccagtaata
      541 actaaatcac aagactgaag ggaattatcc agatttagta gctctgcaat cctgctaaaa
      601 ccactagtta aggtgcctcc taataggaca atggcacctc ctaatcctcc agctgctcca
      661 cttcctggta ttgtctgtaa atcaatggtt gtttggcaaa aaactttttt agcaaagtta
      721 cttgcaattt gatcagtttc ttcaatttga ctaagactcc cacctttttg agggccaaag
      781 accgcagcaa atccttgagg gccatgatat ggattggtca catcagtcgg ccctaatagc
      841 gtaacaggtg atgctaaagt atcaagataa gatcttcctg tcatgaaatc atagtttaaa
      901 ctttccaaaa accctttgcc accatcagaa gtgcctgttc ctcctagcat gatttcgatt
      961 tgagtagctc ctttttgaat ggcatcttta actgccaaac ccaaaccata ggaagtggct
     1021 tgtgcatagc ttactgaatt gggggtgatc ttatcaatac caataatact cgcagattca
     1081 ataaaagctt gctttgcgtg acgataataa gcgactttaa tcgggcgtct taatagatca
     1141 atggttttta cttgatgcca cctccccgcc acggtttgtg agagggctgc taaacttcct
     1201 tctcctccat cagcgatagc tcttgtttca ataactaact gcttatcgac agaaagaagg
     1261 gcttgagcta cactagtgtt aagttctgga gacgttaccg atcccttaaa agaatctatg
     1321 gctaccaaaa ttttcatatc ttcaataaat tccttttctg tatattgtag cagattatcg
     1381 tcctttaaaa ccctattaat agtcaagcta gatctgtctt aagtttttta tctattttga
     1441 gaactcgacc tttttactaa tgttgtctta ttactttctt caccttaaat tattgtcaag
     1501 caaactcaaa aatacaagaa ctttctcgat tgcatttaca tagtcatagc tttgtttagt
     1561 tgctaggatc ttaagcattc aactaatcaa aaaaagactg tttggaaggt ttcaatagct
     1621 ttgccattct aaaaaggatc cgccaatgat ataatattac tatatcatgt cgaatgggga
     1681 ttaaaaatgg gaaatcaaac taaaacggaa cttgaacttg aaaaagagtt gatccatctc
     1741 ttagaaacag gtgaaagtca atggacatat cgtaaagaat taaaaactga agatgcttta
     1801 tgggataatt tctttaagat cttagcgcaa aataacacgc aatatctgaa cgaggagcct
     1861 ttaacagcta gtgaaaaaga gcagattaag aatcaactta actttgtcaa ttactatgaa
     1921 gcggctaaat ggttagctgg tgaaaacggc attgctaaag tacaagtgca acgcgaagat
     1981 gcaaaactag gaacgattcg tttagaagtc gttaaagcag acaatgtggc tggtggaact
     2041 tctgtttatg agattgccaa tcaagttgct ttctctggtt ctcgtgatag acgaggtgat
     2101 gtgacacttc tcatcaatgg cttacctatg atccaaattg aattaaaatc tcagaatcat
     2161 caatgcattg aagcttttaa ccaagtcaaa aagtatgata aagaaggcca gtttagaggt
     2221 atcttttcaa ccttacaaat gtttgtggtc tcaaataaaa cagatacaag gtatatcgct
     2281 gcagctaaag aaaataaatt aaaccctaac ttcttgaccc aatgggtaga tcaaaacaac
     2341 aaaccacaaa aagatctctt tgcctttgcc aaagaagtcc tatctatccc tcgtgctcac
     2401 caaatggtca tgacttactc tgtcattgat gatgataaaa aagcactaat tctccttcgt
     2461 ccttatcaga ttcatgcaat cgaagccgtc gctgaagcga gtcgtcaccg caagtctggc
     2521 tatatctggc acacaacagg ttctggaaaa accttaactt cctataaagt ggctcgcaat
     2581 atccttcaaa taccggccgt tgaaaaatcc atctttgtca ttgaccgaaa ggatttagat
     2641 aatcagacca cttctgcttt tcaatcttat gcgcaaaatg atatctttga tgtcgatgag
     2701 acagaagata cgagacaact catcaaaaat ttagaatcca gtgatcgtcg tgttgtgatc
     2761 accaccattc aaaaactcaa tgctatgatc agtcagatgg aaagttatga cactccaaaa
     2821 ttcaagaaac taaaagagcg tcttgcacac ctaaatgtcg tctttgttgt agacgaatgc
     2881 caccgtgctg tcacgccaga acgtcaacgt catctcacga atacttttcg aaacagtcgc
     2941 tggtatggct ttacaggtac tcctatcttt atggaaaata agcgtgctca attaggtgat
     3001 ttagcccaaa caacggaaca gcaatacggc aaatgtctcc atcaatacac tgtcaaagaa
     3061 gccattcacg ataaagcggt tctaggcttc caagttgagt ataagacaac cattcctgat
     3121 atgcctgaag acagtattcc tgaagaagct tatgatcatg aagaacatat gttagctgtc
     3181 ttaaatagta tcattaatca atcacgtaag aagcttggct ttaataatgg gattggtcag
     3241 acattcgaag gcttattaac cgttaagagt attgctcgtg cccaagccta ttatgatctg
     3301 attcagaaag ttaaagctgg tgaaacggat ttagtcattt ctaagaaggt caaagaaaaa
     3361 ctaccagact ttccaaaggt agctattact tattctatca ctgaaaatga caatgcgtct
     3421 atcagccgac aagataaaat gaccaaaaat ctagaagact ataatcacct ctttggcact
     3481 aactttacca tcgataactt acaaggctat aacagagatt taaatgatcg cttagcccgt
     3541 aaaaaagata aattcaaaga ccgtcatgaa caattagacc tcgtgattgt ggttgaccgt
     3601 ctcttaacag gttttgatgc gccttgttta tcaacgatct ttattgatcg ccagcctatg
     3661 aaacctcagc acattattca agctttctca cgaaccaacc gtatctttga aagtagaaaa
     3721 cattacggtc aggttgtgac tttccaaaca ccacttcgtt ttaaagaagc tgttgacaaa
     3781 gcgcttagcc tctactctaa tgggggtgaa aacgacgttt tggccccttc ttgggaagaa
     3841 gaaaaagcaa gattctttga aaaagtaaca gtattaaaaa atatagttcc tgatccagac
     3901 gctttcccaa ctattgagag cgcacagaca gcttttctca aacaatacgc caaagccttt
     3961 caagcatttg ataaactctt tgcatctgta caagtctata gtgactttaa tgaaacactg
     4021 ttgagtgagg ttgggttatc agatgaagtg attgatactt ataaaggcac ttaccaaaat
     4081 gtcattgcag aaatacgaaa acgaagagaa gatgacgaag ccatcccaga gatcaatatc
     4141 gactatgagc tagaaagtgt tcagatggat gatatcaact atcactatat cttgacctta
     4201 attcaagcct ttgtcgatca agaacaagaa gctcttcaag aaaggctcaa tgacaatccc
     4261 atggatcaat acatccaaga tttggcaaaa tcaaaccctg ctatggctga ctcactagct
     4321 gagttatggc aagatatcca aaaagaatcc aaagcctatg aagggaaaag cattgcttat
     4381 gagttggata acctcattgg tgataagatc caaagggcca tcaaacactt tgcggaccaa
     4441 tggaaggcag atcctgacaa attagccttt gtggcgacta attatcatag tgctaactct
     4501 accaaacaag tgggcatgtc aaccttaaaa gaatccctag actaccaagc ctataaagaa
     4561 aaacaaggtg attctgccat gaataaactc aaatacaaga gccaatttga acgggagtta
     4621 gttcaattca ttagagatca aatccaaccc ttaaaagggc actaggaaag gaaagagatg
     4681 acaaaatcta aacagcctca atatcgcttt gacggttttg aaggggagtg ggaagaaaaa
     4741 gaactagggg atattgttca aattacaatg ggccaatctc catcaagtca aaattatact
     4801 acaaaccctt ctgattatat tctagtacaa ggaaatgccg atataaaaaa tggatatgtt
     4861 tttccgcgtg tctggacaac acaaattaca aaacaagctg acaaaggtga tattattctt
     4921 agtgttaggg ctccagttgg tgatgttgga aagacaaatt atcatgttat tattgggcgt
     4981 ggagttgctg ctataaaagg taatgaattt atctttcaaa tattaaaata cttgaaagaa
     5041 attggttatt ggaaaagaat tagtacaggt tcaacttttg atagcattag ctctagtaat
     5101 atcaaatatg ctaaaattca aattccctcc ctccccgaac aagaagctat tggcgaactt
     5161 ttccaaacgg ttgatcaatt gattcagttg caggatcaaa agctagcaac tctaaaagaa
     5221 caaaagcaaa ccttcctcag aaagatgttc ccagctcaag gacaaaaagt ccctgaaatc
     5281 cgtttacaag gttttgatgg tgagtgggaa gagaagaaat tgggagagat atctcggatg
     5341 ttttcaggtg gtactcctag cgtaggtatt tctgaatact ataacggtaa tattcctttc
     5401 attagatctt ctgagattaa tagtgatcaa acagagttat ttatcacaaa caaaggtcta
     5461 tcaaattcat cagcaaaaat agtggaaaaa aatacattat tatacgctct ctacggtgca
     5521 actagtggag aagttggact ttcaagaata agtggagcta ttaatcaagc aattttagcc
     5581 attattcctg agaaaaaata ttcttctctt tttataaaaa attggttata taaacaaaaa
     5641 tcttcaatta ttgagaaata tttacagggt ggtcaaggaa atttatctgg ttccattgtg
     5701 aaaggattag agctttatct accctccctc cccgaacaag aagccatcgg tgacttcttc
     5761 caaaccctag accaacaaat gagtcaaatc gaagataaat taacagaact taaagcactc
     5821 aaacaaacat tactcaatcg tttattcgta taagaaagga ctcacatggc agagaaaaca
     5881 acttcactcc gtcaagcact atggcattcg gccgaccaat tacgtggcca aatggatgcc
     5941 aatgactata aaaactatct tcttggactt attttttaca aacacttatc tgataaatta
     6001 ctcttggctg tttgtgataa tctagaaaaa cacttcaata cctttacaga ggctcaaaaa
     6061 atctttgaag atgcttatca agatgaaggc ctaaaagatg acctcatttc tgttgttact
     6121 ggtgatttag gttactttat cgaaccaaca ctgacctttg aaaaactcat ccaagatgtt
     6181 tatcacaata ctttccaatt agaatcatta gctcaaggtt ttcgcgatat tgaacaaagt
     6241 ggtgaagact ttgaaaactt atttgaagat attgacctct actctaaaaa attaggctct
     6301 actcctcaaa aacaaaatca aaccatttct aatgtcatga aaacattaaa tgaaattgac
     6361 tttgaggcag tagatgggga tactttaggc gatgcttatg agtacttgat tggtgaattt
     6421 gccagtgagt caggaaaaaa agcaggtgag ttctataccc cacaagctgt ctctcacttg
     6481 atgactcaga ttgtcttttt aggtcgtgaa gatcaaaaag gaatgaccct ctatgaccct
     6541 gctatgggat ctggatcact ccttttaaat gctaagaaat atagtaacca atccgatacc
     6601 gtttcttact atggtcaaga aatcaatact tctacttata acttggctcg tatgaacatg
     6661 atgcttcatg gcgttgccat cgaaaaccaa cacttaagta acgctgatac cttggatgca
     6721 gactggccaa cagatgagcc aaccaacttt gatggggtgt tgatgaaccc accttattct
     6781 ttgaaatggt cagcgactgc tggtttctta acggatccac gtttttcaag ttatggtgta
     6841 ttagcaccaa aatcaaaagc tgactttgcc tttttacttc atggtttcta tcatttaaaa
     6901 aatacaggaa ctatggcaat tgtcttacca catggtgttc ttttccgtgg agctgcagaa
     6961 ggcaagattc gccaaaaact actcgaacaa ggggctatcg ataccattat cggactccca
     7021 tcaaatatct tttataatac aagcatccct acgactatta tcatattaaa gaagaacaga
     7081 accaacaaag atgtcttctt tatcgatgct tcaaaagagt ttgataaagg caaaaatcaa
     7141 aacacaatga cagatagcca tatcaaaaag atccttgatg cttataagag tcgtgataat
     7201 tctgataagt tttcatattt agcctcattt gatgaaatca ttgaaaatga ctataactta
     7261 aatatcccac gctatgttga tacctttgag gaagtcccag ttaaaccact gccagaatta
     7321 gctaaacagc tcagtgacat tgatcaagaa attgccaaaa caaatgccaa actagatcaa
     7381 ctcatgaaac aactagtcgg aacaaccaaa gaagcacaag acgaattgga tacttttaga
     7441 aactaaaaga caaaaaaaca ccacagtaga tgattactac tgtggcgttt tatttaaaat
     7501 tgagtagtga acctttattg agtacttatc aaacaagatt ctccttcttc acctataaat
     7561 caaaatagaa tcatctcatc taactttact ttgtccgttt ctttgtttta tttaaaatag
     7621 ttatttgaag ttacaatgat ttctcaaacg tttagaaagc ttaaacacgg ttaagagaaa
     7681 ttttcaggac aacttttgat ccttccacaa aaaccatggt gcgaaccata aattagttcc
     7741 aatcgttgat atataagcat atattaacgt tctgggagtt gtgaagcttt acgagttttt
     7801 ttagacctgg tttaaacaac ttttgtttga ctaaatttaa aaagcttttc atatcaggca
     7861 ttgccctact ttttataaaa gcgttatctc aatcaatttc aatcaaaaag aactcaaaaa
     7921 caatgagttt aaatctgggt atttaacagg aaatccctag caacgacaca agtaaaactt
     7981 atgtcgtttg attatctgca actcagaaat ccataaaata ccctaattgt tcggctttgt
     8041 agatagcctc ttgcttatta tttaccaaaa gctttgagta gatgtgggtc aaatgattaa
     8101 atactgttct cctactaatt tgtaacgttt cctctatttc ttttatagag aatcctttct
     8161 tactcaaatt taagatagct atttcctggt cagttaaaga ttcaacataa tcctgagatt
     8221 cgatttgttc aaaatacttt tttccagaat ccactttttt taagatagaa atgagttgtt
     8281 tagggtctat atttttatct acaaaaccgt atgctcctac tttttttgcc ctctctctat
     8341 agattgattt aacatatcct gtcaacataa caactttcaa atgaggagta gactgtatga
     8401 gttcttttgc tatctccaat ccattttctt tagaaatatt tgttaaatta atatcaagca
     8461 atataatatc gtacttagac aaatcaatcg tcacatcgtt aaaatgagaa gtaatcgtat
     8521 ctatgacatc tacttcatca tactgttgga ataacagttg gatactcttt gcaaatagtc
     8581 tgtggtcatc aattaataaa atcttcataa cacaatttcc aatctatggg aagtaatatt
     8641 ctgatagtaa attgtttagt atccatttgt agttctagat ctccatcaaa agctgctagt
     8701 gtttcttgaa atgatttcaa tcctctgcca taacttatag agtgtacttt ttccactact
     8761 tgattgctct cctcaatgat aataatatca gattgaatcg ttaaagataa acgaatgtct
     8821 tttccatctc catattttat agcattgttt attagctctt ttataaacct ataaacaata
     8881 tctccatatg gggatggcac taccatatta tctgaacagt taaaatacaa taaggtatta
     8941 ctttttctac ttttaacaat atcatcaaaa agagactgta tgttttcttt cattgtttga
     9001 ttagcgggaa ctattgggtg gtaagtatca atttcttctc tgataccaga aactaaatca
     9061 ttcaactcat taacaataaa accatgtgtt atattactat tttctagaga aagcaagttt
     9121 tttatcgcta tgatattttg taaaacatca tcatgcaaat aatttgagaa ctccac
//
LOCUS       DAUDWO010000052         9086 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.053, whole genome shotgun sequence.
ACCESSION   DAUDWO010000052 DAUDWO010000000
VERSION     DAUDWO010000052.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9086)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9086)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9086
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.053"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            3..2276
                     /locus_tag="VHC05_001567"
     CDS             3..2276
                     /locus_tag="VHC05_001567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip domain-containing protein"
                     /protein_id="HEQ5402857.1"
                     /translation="MLEELKTLIKNPKLMITMIGVALVPALYNLSFLGSMWDPYGRVN
                     DLPIAVVNHDKPAKRADKSLTIGNDMVDKMSKSKDLEYHFVSAKQAQEGLKEGDYYMV
                     ITLPEDLSQRAATLLNPEPQKLTIRYQTSKGHGMVAAKMGETAMAKLKESVSQNITKT
                     YTSAVFSSMTDLQSGLKEASAGSQTLASGAKTAQAGSQTLSTNLAALTGASQQFQQGT
                     GRLTSGLTTYTDGVNQVKNGLGTLSTDIPNYLNGVSRLSQGASQLNQGLSQLTQATTL
                     SDEKAKGIQSLIVGLPVLNQGIQQLNTELSTLQPPNLNADELGNSLGAIAQAAKQVIA
                     EETAAQNEELSALQATSVYQSLTAEQQGELAAALSQSDKSQTVSAAQTILSSVQTLST
                     SLQSLSQEDQSKQLEQLKEAVAQIANQSNQALPGASSALTELSTGLAKVNGSLNQQVL
                     PGSNQLTTGLAQLNRYNTAIGSGVIKLSEGTNALSSKSGELLDGSHQLSEGATKLADS
                     SSQLSQGGHQLTSGLTELSTGLSTLNGSLAKASQQLSLVSVTDKNAKAVAKPLVLNEK
                     DKDGVKTNGIGMAPYMIAVSLMVVALSTNVIFANSLSGRPVKDKWDWAKQKFVINGFI
                     STMGSIVLYLAIQLLGFEARYGMETLGFIMLSGWTFMALVTALVGWDDRYGSFASLVM
                     LLLQVGSSGGSYPIELSGAFFQKLHPFLPMTYVVSGLRQTISLSGHIGVEVKVLTGFL
                     LAFMVLALLIYRPKKTV"
     gene            complement(2392..3471)
                     /locus_tag="VHC05_001568"
     CDS             complement(2392..3471)
                     /locus_tag="VHC05_001568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011055103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4097 domain-containing protein"
                     /protein_id="HEQ5402858.1"
                     /translation="MKNISRKCFITSVLCIILGGILLGAGYATGGLQDIKHQTAPKKV
                     IKTFDQITALDIDSSASTITVETGPVQRPTVTYYTHPKFIDPIVTTVTGKTLSLSQKP
                     KDVVITGGIEILGFTLNNSRQEKNYRSITITVPEKTSLNEVKGSNVPHTTLSNLTVQD
                     MQFDGNLTLLHTKVKKATITGMLEATKSQLTNLELKADYSFSNLTDSSVENGTISLGN
                     GQLTTKDTTLKAVNIQSLHSGGIEAERTTLENVTFTVSKSKEEEENDYYDNDAIFTAH
                     ALTLKGTNTITGGDIDVDITLTKAKAIAYRARTENGKVSLGSQLTPAKIGKESTSDVI
                     SYVAENKAATGNLTVNLNKGDITIK"
     gene            complement(3468..4055)
                     /locus_tag="VHC05_001569"
     CDS             complement(3468..4055)
                     /locus_tag="VHC05_001569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1700 domain-containing protein"
                     /protein_id="HEQ5402859.1"
                     /translation="MTRTEYLAELDKYLRKLPREDYHEAMEYYIEYFDEAGPDKESQV
                     IDDLGNPKEAASEIISNVLGKHLATPEKTPKNRATIIGLTILSLFAAPIALPVLLALI
                     LFIIACLMLGLTAIFAAYIFGLAGILVAGVTLFESLTLIGSSIPAQAMGIGSALLCFG
                     GGLLIWIIATAILRFSGRAFVAFIKWISNKKGAQA"
     gene            complement(4042..4368)
                     /locus_tag="VHC05_001570"
     CDS             complement(4042..4368)
                     /locus_tag="VHC05_001570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HEQ5402860.1"
                     /translation="MYFPVSATLIEFLILAIVEKNDSYGYDISQTIKLVANIKESTLY
                     PILKKLEKAGFLTTYSQEHQGRKRKYYAVTSSGRAQLIFLKKEWQSYKFALDGIIEGS
                     LRHDKD"
     gene            4575..5216
                     /locus_tag="VHC05_001571"
     CDS             4575..5216
                     /locus_tag="VHC05_001571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA pyrophosphatase"
                     /protein_id="HEQ5402861.1"
                     /translation="MKDLLKQYQAKPLGEEKRYAVFLPLILVNDDWHVLYEVRSQHIS
                     QPGEVSFPGGRVENQETLQEAAIRETVEELTVDASQIQLWGEIDYLVQSSRTIHCFVG
                     QLVVDDWESIQPNEEVDKVFTVPLRQLLVTDPVYYHLEATPIETTDFPFDRIRNGKYY
                     QFSQEYRSIPFYENLEETIWGMTAQFTKCLTDILNDESIAKKNPLDIEKSKGR"
     gene            complement(5263..6105)
                     /locus_tag="VHC05_001572"
     CDS             complement(5263..6105)
                     /locus_tag="VHC05_001572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF368 domain-containing protein"
                     /protein_id="HEQ5402862.1"
                     /translation="MVSFISRVFKGMIIALGFILPGVSGGVLAAILGIYERMISFLAH
                     MRDNFIENVLFFLPVGIGGILGIALFSFPVEFLLKHYQVIVLWGFAGAIVGTIPSLIK
                     ESTKQSQRDKVDWLWLVLTFVISGLGLYFLNDLIGTLPANFLTFILAGALIALGVLVP
                     GLSPSNLLLILGLYGPMLIGFKSLDLLGTFLPIAIGGVLAILAFSKSMDYALQHHHSK
                     VYHFIIGIVLSSTLLILIPNSSSPESISYSHAGILTWLMAVVLFALGIWLGLWMSQLE
                     EKYK"
     gene            6508..6552
                     /locus_tag="VHC05_001573"
                     /pseudo
     CDS             6508..6552
                     /locus_tag="VHC05_001573"
                     /inference="COORDINATES: protein motif:HMM:NF013540.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            6559..6840
                     /locus_tag="VHC05_001574"
     CDS             6559..6840
                     /locus_tag="VHC05_001574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEQ5402863.1"
                     /translation="MLSKSLQVPLEQLIAEDIPKMTLIIKDEEIKQCDRNTHIMLFGT
                     LLIAISIYPIMSWLGWWGYGPVAILWLIIMRSALRIERFKKTYDVQTYR"
     gene            complement(7316..7918)
                     /locus_tag="VHC05_001575"
     CDS             complement(7316..7918)
                     /locus_tag="VHC05_001575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003039416.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402864.1"
                     /translation="MTTKTYFMRSFNLILYLLLIAPICYVFGWLFNLVSVQLSTVTFV
                     NLDTVKNVTDTISSVCYGFALISLLLALLSGLKMIQRLNTDSLGNYCQSIYRTFLLRH
                     FLFQRERVQKVSNFEHQTVTTINPIHNGFNRAVRKCIVDIRKDAITVFLKVPRDQQGQ
                     KILKDTGVQLKEEIVIQHTDYYFSSPVRVRNQLWFIGQKR"
     gene            complement(7915..8667)
                     /locus_tag="VHC05_001576"
     CDS             complement(7915..8667)
                     /locus_tag="VHC05_001576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HEQ5402865.1"
                     /translation="MAIPDLDKFSSSLQQGKIPVIKHFELNLDKGSHWAIAGNSGSGK
                     PYALTYFLSVLKPMSGLIIIDPKFDTPSQWARENKIAVIHPVENHSKSDFVSQVNEQL
                     NQCATLIQKRQAILYDNPNHQFTHLTIVIDEVLALSEGVNKNIREAFFSLLSQIALLG
                     HATKIHLFLGSQRFDHNTIPISVREQLNVLLQIGNINQKTTQFLFPDLDPEGIVIPTG
                     HGTGIIQVVDNEHSYQVLPLLCPTYYTKRGIL"
     gene            complement(8733..>9086)
                     /locus_tag="VHC05_001577"
     CDS             complement(8733..>9086)
                     /locus_tag="VHC05_001577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011529130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402866.1"
                     /translation="KSFEVNVCGILFELDGNGIPSTFRQENIDPLVNKWWYDNVSTEI
                     IPNLIKKLKENPLFNIGFLVDDILERMYKENIPKSYLTSVPLVISKKARSTLSIKSNG
                     SQKINKSKFAQILSL"
BASE COUNT         2879 a         1608 c         1810 g         2789 t
ORIGIN      
        1 atatgttaga agaattgaaa acacttatta aaaatccaaa attaatgatt acaatgattg
       61 gtgtggccct agtgcctgcc ttatataatt tatcctttct aggctcaatg tgggatcctt
      121 atggtcgggt caatgacctt cccattgctg ttgttaatca tgataagcct gcaaagagag
      181 ctgataagtc attgacaatt gggaatgata tggtggacaa gatgtctaaa agtaaagatt
      241 tagagtatca ttttgtctca gctaagcaag ctcaagaggg acttaaagaa ggtgattatt
      301 atatggttat tactttaccc gaagatcttt ctcaacgggc agcaacctta ttaaatcccg
      361 aaccccaaaa attaactatc cgttaccaaa cgagtaaagg acatggaatg gtcgctgcta
      421 agatggggga aacagcgatg gctaagttga aagagtctgt ttcgcaaaac attacgaaga
      481 cttatacctc agcagttttt agcagtatga cagacctcca atcaggatta aaagaagcct
      541 cagctggaag tcaaacactt gcttcaggag cgaagaccgc tcaggcgggg agtcaaacac
      601 tttcgacgaa cttagcagcc ttaacgggtg ctagccaaca gtttcaacaa ggtactggtc
      661 gattgacatc aggtttgact acctatacag atggtgtcaa ccaagtcaag aatgggttag
      721 gaacattatc aacggacatc cccaattatc tgaacggggt ttctaggtta tcccagggag
      781 cttctcagct taatcagggt ctttcacagt tgacacaagc aacaacactt tctgacgaga
      841 aagctaaggg aattcaatcc ttaattgtag gactaccagt cctaaatcaa ggcattcagc
      901 aactaaatac agagctatca acattgcaac cccctaacct taatgctgat gagttaggta
      961 atagcttagg agctatcgct caagctgcca aacaagtcat tgctgaagag actgccgctc
     1021 agaatgaaga actatcggct ctccaagcta ctagcgttta ccaatcatta actgctgaac
     1081 aacaaggaga gttagctgcg gccctcagtc aatctgataa aagtcagacc gtatctgcag
     1141 cccaaactat tttaagttct gttcaaactt tgtcaacaag tttacagtct ctctctcaag
     1201 aagatcagtc aaaacagttg gagcaactta aggaagctgt tgcacagatt gctaatcaat
     1261 ccaatcaagc tttgccggga gcaagttctg ctttaactga attatcaacg ggattagcaa
     1321 aggtaaatgg tagcttaaat caacaagttc taccaggaag taatcaattg acaacaggat
     1381 tagcacaatt aaacaggtat aatactgcca ttggttctgg ggtaataaaa ctctcagaag
     1441 gtaccaatgc cttgtcatcc aagtccggag aattactaga tggtagccat caattatcag
     1501 agggtgctac taaactagct gatagtagtt ctcaattgag tcagggtggt catcaattaa
     1561 cgagcggatt gactgaatta tcaacaggat tatcaacctt aaatggttcc ttagccaaag
     1621 cctctcagca gttatcgctt gtttctgtga ctgataaaaa tgctaaagct gtcgcaaaac
     1681 ctcttgtgtt aaatgagaaa gacaaagatg gtgttaagac gaatgggatc gggatggcac
     1741 cttatatgat tgctgtttct ctaatggttg tggccctttc aaccaacgtc atttttgcta
     1801 attctttatc tggtcgtccg gtcaaagata aatgggattg ggctaaacaa aaatttgtta
     1861 ttaatggttt tatttcgact atgggatcca ttgttctcta cttagctatt caattattag
     1921 ggtttgaagc ccgttatggt atggaaacct taggatttat tatgctaagt ggttggacgt
     1981 ttatggctct tgtcacagct ttggtcggtt gggatgatcg atatggctct tttgcttctt
     2041 tggtcatgtt attgcttcag gttggctctt caggtggctc ttaccccatt gagttaagtg
     2101 gagcattctt ccaaaagtta catcctttct taccaatgac ttatgtggta tctggtttac
     2161 gacaaaccat ttcattatca ggtcatattg gagtagaagt gaaagtctta actggtttct
     2221 tactggcatt tatggtatta gcactactca tttatcgtcc taagaaaaca gtctaaataa
     2281 aataacctca aaaaaaacag catctaaggc agttacacta gatgctgttt tttgtcttat
     2341 tttgacaata acttgacaat ttctgtcaag ttttttattg tcttgttaag atcatttgat
     2401 agtaatgtct cccttattga gattaaccgt taaatttcca gtagctgctt tattctcagc
     2461 cacataagaa ataacatctg aagttgattc cttaccaatc ttagctggtg tcagctgtga
     2521 gccaagggag actttaccat tttcggttct tgctctgtag gcgatggcct ttgcttttgt
     2581 caaggttatg tcaacatcaa tatcaccacc agtaatagta ttagtccctt taagggtaag
     2641 ggcatgagcg gtgaagatag catcattgtc atagtagtcg ttctcctctt cttctttgct
     2701 tttagaaaca gtgaaggtca cattttcaag ggttgttctc tcggcttcta taccaccaga
     2761 gtgtaatgat tgaatattga cagcttttag agtggtatct ttagtagtta gttgtccatt
     2821 tcctaagctg atggtcccat tttccacact agaatcagtc aggtttgaaa aagaatagtc
     2881 agcttttaac tcgagatttg ttaactgact tttagtggct tccaacatac cagtgatagt
     2941 agctttcttg actttggtat gtaaaagagt aagattgcca tcgaattgca tatcttggac
     3001 agttagattt gacaaagtgg tatgtgggac attacttccc ttaacttcat tgaggctagt
     3061 tttttcagga acagtaatgg taatagaacg gtagttcttc tcttgacgac tattattgag
     3121 agtaaaacct aaaatttcaa ttccaccagt gatgacaacg tctttaggtt tttgcgaaag
     3181 agatagggtc ttacctgtta ctgttgtgac gatagggtca ataaatttag gatgtgtgta
     3241 ataggtcact gttggtcttt gaacgggtcc tgtctctact gtaatagttg aggcagaact
     3301 gtcaatatca agagcagtta tttggtcaaa tgttttgatg acctttttgg gagctgtttg
     3361 gtgtttaatg tcctgaagtc ctccagttgc atagccagcc cctagaagaa tgcctcctag
     3421 aataatacat aacacactgg ttataaagca tttgcgtgag atatttttca tgcttgagct
     3481 cctttcttat tactgatcca cttaataaag gcaacaaaag cccgtcctga aaaacgaagg
     3541 attgctgtgg caataatcca aataagaaga ccaccaccaa aacacaacaa ggcgctgccg
     3601 atgcccatag cttgtgcagg aatagatgag ccaatcaagg tcaagctttc aaacagagtc
     3661 actcctgcga caagaatacc tgcaagccca aaaatgtagg cggcaaagat agctgtgagc
     3721 ccgagcatta ggcaggcaat aataaagaga atcaacgcca gcaatacggg taaagcaatc
     3781 ggagcagcaa agagggacaa aatggttaat ccaataattg ttgcccgatt tttgggagtt
     3841 ttctcgggag ttgccaagtg ttttcctaga acatttgaaa tgatttcact ggcagcttcc
     3901 ttaggatttc ctaaatcgtc gataacctgg ctttctttgt caggaccagc ttcatcaaaa
     3961 tattcaatat aatattccat cgcttcatgg tagtcttctc taggtagttt gcgcaagtat
     4021 ttatctagtt ctgctagata ctcagtcctt gtcatgtctt aagctccctt caataatccc
     4081 gtctaaggca aatttatagc tctgccattc tttttttaga aaaatcagct gtgctctccc
     4141 cgaagaagtg acagcataat atttacgctt tcgtccctga tgttcttgac tataagttgt
     4201 caaaaaacct gctttctcca attttttaag aataggatag agagtggatt ctttgatatt
     4261 agccactagt ttaatggttt gactaatatc gtaaccgtaa gaatcatttt tttcgacaat
     4321 ggctaaaatc agaaattcaa tcaaggtagc cgatactgga aaatacattt taggctcctt
     4381 tcatatataa aaattttata tataattatt ttacatattt agtataagct tagttttttg
     4441 atatgtcaat attttatata taaaaaaata acatatatat caaaaatcac taactaggag
     4501 taataagttg accaaaaagc taggattggt tatgatgaag ataagattaa cggaaagaga
     4561 aattagggaa ggctatgaag gacttattaa aacagtatca ggcaaaacca ctaggagagg
     4621 agaagcggta cgccgtattt ttacctctta ttcttgtcaa tgatgactgg catgtcttat
     4681 atgaagtcag aagtcagcat atttcacaac cgggggaagt ttctttccca gggggacgag
     4741 tagaaaatca ggagacactt caagaagctg ctatccgaga aacagttgag gaattgactg
     4801 ttgatgcgtc ccagatccag ctatggggtg aaattgatta tttagtacag tcttctagaa
     4861 ctattcattg tttcgttggt caattagtcg ttgatgactg ggaaagcata cagcctaacg
     4921 aagaagttga caaggtcttt acagtacctt tacgtcagct acttgtcact gatcctgtct
     4981 attatcattt agaagccact cctattgaga caacggattt tccttttgac cgtattcgta
     5041 atgggaaata ctaccaattt agtcaagaat accgtagtat tccgttttat gaaaatctag
     5101 aagaaaccat atggggaatg actgcccagt ttactaagtg tttaaccgat attctaaatg
     5161 atgaatcaat tgcaaagaaa aaccccttag atattgaaaa atctaagggg agatagagca
     5221 ctagtttgtt ggcgtcaact ttttgtcaac aacctgtaaa ggttatttgt atttttcttc
     5281 taattgactc atccaaagtc cgagccaaat accaagagca aataacacaa cggccataag
     5341 ccaggttaag atacctgcat gactgtagga aatggattcg ggactactac tatttggaat
     5401 aagaattaat agcgtgctgg ataatacaat accaatgata aagtggtaaa cttttgaatg
     5461 atggtgctgt aaagcataat ccatactttt agaaaaagcc aagatggcta ggactcctcc
     5521 gatagcaata ggtaagaaag tccctaataa atccaaagat ttgaatccta ttaacatagg
     5581 accatagagt cctaagataa gtaagagatt tgacgggctt agtccaggga ccagtactcc
     5641 taaagcaatt aaggcacctg ctaaaataaa ggttaaaaag ttagctggta aggtaccgat
     5701 taagtcattt aagaagtaaa gacctagtcc tgaaataaca aaggtaagga ctagccatag
     5761 ccagtcaact ttgtctcttt gagactgctt ggttgactcc ttaatcagac taggaatagt
     5821 gccgacaata gcgccagcaa atccccataa gacgataact tgatagtgct taagcaaaaa
     5881 ctcaacgggg aaagaaaaga gagcaatacc taaaatacca ccaattccta ctggtaagaa
     5941 aaataagaca ttttcaataa agttatccct catatgagct aaaaaggaaa tcattcgctc
     6001 atagattcct aaaatggctg cgagaacacc accggataca ccaggtaaaa taaaacctag
     6061 tgcaataatc atgcctttaa aaactcttga aataaatgaa accattgttg cctcctgaaa
     6121 agaatgattt tattgtatca taaatttaaa gaattgctga cacaaagctg catatcccta
     6181 ctaaaataat tgttcctaat aaataataca ttcaattttg aagatatttt ccttaaacat
     6241 catgtctttg tgatcaagtc aagtttgatt gtcaaagttg taaataaaat ttacaaagac
     6301 tgtaaacttt acgataatta tcaaaaagat aaacgaaaaa aagcttaggt caaagacttt
     6361 tgatagtaaa cttattgaag aaggattata gtagctatta aaaaggagat ttattatggg
     6421 ctttaaaaac cagttacctt attattgaaa aaaattacag atgtcacaag aagagcttgc
     6481 tgaaatgatg tatgtttcaa gaagactatc tcaaactggg aaaacggtaa aagctatcca
     6541 gacctgcaaa atcttttgat gttaagtaag tccttacagg ttcctttaga gcaactaata
     6601 gcagaagata tcccaaaaat gactttaatt attaaggatg aggagattaa acaatgtgat
     6661 aggaatacgc atattatgtt atttgggaca ctcctaattg ctatcagtat ttatcctata
     6721 atgtcttggt taggttggtg gggatatggt ccggttgcta tcttatggtt gataatcatg
     6781 cgtagcgcct taagaattga gcgatttaaa aagacatatg atgttcagac ttaccgataa
     6841 cttgaagcta tagcaaaggg tgagagctta gatcagattg ataagattaa agaaaaagca
     6901 aaatatcctt atcaaaaagc atggattgtt attgcgtaca caggattgac agtgttaata
     6961 accctactct ctattttgtt ttttcatttg tttttttaaa cacgaaaaaa gcctttgaaa
     7021 cgttcatttc ataggctttt ctcatctcaa ttattttgct tctgtaaagg ttaagtattt
     7081 tctattttag ctgttataaa ccttattgta tcaatattta ttgatagttg cttaataaaa
     7141 ggtagagtga atggtagagt agttattgcg ttagttcagc aatcttttca agataaataa
     7201 atacccacag cttctaactt tcgttgtcgt agtaacccca ataggtcatg atagataaga
     7261 atataaaaaa ggggctgtct ggcttttgct taacgcaagc cacagcccca aggaattaac
     7321 gcttttgacc aataaaccac aattggttac gaactcgaac aggagaagag aaataatagt
     7381 ctgtgtgttg gatgacaatc tcttctttca gttgtactcc cgtatccttt aggatttttt
     7441 gcccctgttg gtctctagga acttttagaa atacagtaat ggcatctttt cgtatatcta
     7501 cgatacactt acgtacagct cggttaaacc cgttatggat tggattgata gtggtaacgg
     7561 tctggtgttc aaagttgctt accttctgta ctcgttcacg ctggaaaagg aagtgtctta
     7621 atagaaaggt gcgataaata gattggcagt agttcccaag gctatctgta ttcaagcgtt
     7681 gtatcatctt taatccagat aataaggcta gaagtaaaga aataagagcg aatccataac
     7741 atacagaact aatggtatca gtaacgtttt taaccgtatc cagattgaca aatgtgacgg
     7801 tagataattg aactgaaaca agattgaaca gccaaccgaa cacatagcag attggagcaa
     7861 taagcagtaa gtataatatg agattgaagc ttctcatgaa gtaggtttta gtggtcatag
     7921 gatacctcgc ttagtatagt aggttggaca gagtaagggt agaacttgat aggagtgttc
     7981 attatcgaca acttgaatga tacctgttcc gtgtcctgtt ggaatgacaa tcccctctgg
     8041 atctaggtct ggaaataaga attgagtggt tttctgattg atatttccaa tttgcaataa
     8101 tacgtttagc tgttccctca ctgaaatggg aatagtgtta tggtcaaaac gctggcttcc
     8161 caagaataga tggattttag tagcatgtcc caacaaggca atttgtgata gtagggagaa
     8221 aaaagcttct ctgatattct tattgactcc ctctgataga gcgaggactt catcaataac
     8281 aatagttaga tgggtaaatt gatgattggg attatcatac aagatagctt gtcgtttctg
     8341 aatgagagtt gcacactggt ttaattgttc attgacttgt gaaacgaaat cagattttga
     8401 atggttttct actgggtgga taacggcaat tttattttct cttgcccatt ggctaggggt
     8461 atcgaatttt gggtcaatga taattaggcc ggacataggt ttcaggacac tcaagaagta
     8521 agtgagagcg tacggtttcc cagaacctga atttccagca atagcccagt gactcccctt
     8581 atctaaattg agttcgaagt gctttatgac aggaattttc ccctgttgta agctagatga
     8641 aaatttatct aaatcaggaa tcgccaagcg ttctgaaatc ccctttctcc aagggaagaa
     8701 taatccacgt tgaatgtgta agtcatccgt ctctaaaggg acaaaatctg tgcaaatttt
     8761 gatttattta ttttttgact tccgtttgac ttaatcgata aagttgacct tgcttttttg
     8821 gaaataacta atgggacgga cgtaaggtaa gattttggga tattttcttt atacattcgt
     8881 tctagaatat catcaaccag gaatccgata ttaaatagtg gattttcttt gagttttttt
     8941 attaggttag ggataatttc tgtcgaaaca ttatcatacc accatttatt gacgagggga
     9001 tcaatgtttt cttgcctaaa tgttgagggt atgccatttc cgtctaattc aaataggata
     9061 ccacagacat taacttcaaa tgattt
//
LOCUS       DAUDWO010000053         9076 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.054, whole genome shotgun sequence.
ACCESSION   DAUDWO010000053 DAUDWO010000000
VERSION     DAUDWO010000053.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9076)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9076)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9076
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.054"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            192..2192
                     /gene="metG"
                     /locus_tag="VHC05_001578"
     CDS             192..2192
                     /gene="metG"
                     /locus_tag="VHC05_001578"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HEQ5402867.1"
                     /translation="MMKKPFYITTPIYYPSGKLHIGSAYTTIACDVLARYKRLMGHEV
                     FYLTGLDEHGQKIQTKAKEAGITPQTYVDNMAKDVKALWQLLDISYDTFIRTTDDYHE
                     EVVAAVFEKLLAQDDIYLGEYSGWYSVSDEEFFTESQLKEVFRDEDGQVIGGIAPSGH
                     EVEWVSEESYFLRLSKYADRLVAFFKERPDFIQPDGRMNEMVKNFIEPGLEDLAVSRT
                     TFTWGVPVPSDPKHVVYVWIDALLNYATALGYGQANHANFDKFWNGTVFHMVGKDILR
                     FHSIYWPILLMMLDLPMPDRLIAHGWFVMKDGKMSKSKGNVVYPEMLVERFGLDPLRY
                     YLMRSLPVGSDGTFTPEDYVGRINYELANDLGNLLNRTVAMINKYFDGTVPAYVDNGT
                     AFDADLSQLIDAQLADYHKHMEAVDYPRALEAIWTIIARTNKYIDETAPWVLAKEDGD
                     KAQLASVMAHLAASLRVVAHVIQPFMMETSAAIMAQLGLAPVSDLSTLALADFPANTK
                     VVAKGTPIFPRLDMEAEIDYIKAQMGDSSAISQEKEWVPEEVALKSEKDVITFETFDA
                     VEIRVAEVKEVSKVEGSEKLLRFRVDAGDGQDRQILSGIAKFYPNEQELVGKKLQIVA
                     NLKPRKMMKQYISQGMILSAEHGDQLTVLTVDPSVPNGSIIG"
     gene            2687..3700
                     /gene="nrdF"
                     /locus_tag="VHC05_001579"
     CDS             2687..3700
                     /gene="nrdF"
                     /locus_tag="VHC05_001579"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HEQ5402868.1"
                     /translation="MTQYYYERSQSPIEYALSETQKQLRSINWNYLNDDKDLEVWNRV
                     TQNFWLPEKVPVSNDLNSWRSLGEDWQQLITRTYTGLTLLDTVQATVGDVAQIQHSQT
                     DHEQVIYTNFAFMVGIHARSYGTIFSTLCSSEQIEEAHEWVVSTQSLQDRARVLIPYY
                     TGDDPLKSKVAAAMMPGFLLYGGFYLPFYLSARGKMPNTSDIIRLILRDKVIHNYYSG
                     YKYQQKVARLSPEKQAEMKAFVFDLLYELIDLEKAYLRELYAGFDLAEDAIRFSLYNA
                     GKFLQNLGYESPFTEEETRVSPEVFAQLSARADENHDFFSGNGSSYVMGITEETTDDD
                     WEF"
     gene            3704..4138
                     /gene="nrdI"
                     /locus_tag="VHC05_001580"
     CDS             3704..4138
                     /gene="nrdI"
                     /locus_tag="VHC05_001580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class Ib ribonucleoside-diphosphate reductase
                     assembly flavoprotein NrdI"
                     /protein_id="HEQ5402869.1"
                     /translation="MAELIIVYFSSKSNNTHRFVQKLGLPAQRIPVDNRPLEVSTHYL
                     LIVPTYAAGGSDAKGAVPKQVIRFLNNPNNRKHCKGVISSGNTNFGDTFALAGPIISQ
                     KLQVPLLHQFELLGTATDVKKVQAIFARLKHHTHDKQNKPTT"
     gene            4158..6338
                     /gene="nrdE"
                     /locus_tag="VHC05_001581"
     CDS             4158..6338
                     /gene="nrdE"
                     /locus_tag="VHC05_001581"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HEQ5402870.1"
                     /translation="MSQTNASYLSLNALTRFKKPDGSYHFDSDKEAVRRYLEEHVSPN
                     QMAFNSLEDKLAYLINEGYYEQAIFDAYPNDLIKEAFHYAYQQGYRFLNLMGAMKFYQ
                     SYALKTLDGKHYLETFEDRAVMNALFLADGDQTFVFDVIDAILHRRFQPATPTFLNAG
                     KKRRGEYISCYLLRVEDNMESISRAISTSLQLSKRGGGVALCLTNLREIGAPIKGIEN
                     QATGIVPVMKLLEDSFSYANQLGQRQGAGAVYLHAHHPEVLTFLDTKRENADEKIRIK
                     SLALGLVIPDITFQLAKENKDMALFSPYDIKRAYGKDMSDISITEEYDKLLANPAIKK
                     TYISARKFFQLIAELHFESGYPYLLFDDTVNKRNPHAKKGRIVMSNLCSEIAQVSTPS
                     TFKEDLSFETIGEDICCNLGSINIAQAMADAPHFEQLITTSIRALDRVSRLSDLNCAP
                     SVETGNAANHAVGLGAMNLHGFLATNHIYYDTKEAVDFTDLFFHAMAYYAFKASCQLA
                     KEKGAFAGFSLSTYADGTYFAKYLQEDAKPQTAKVATLLQDYGFTLPTVADWQALVAD
                     IKQFGLANAHLLAVAPTGSISYLSSCTPSLQPVVAPVEVRKEGSLGRIYVPAYQIDQA
                     NYAYYERGAYEVGPKAIIDVVAAAQKHVDQAISLTLFMTDQATTRDLNRSYIQAFKQN
                     CASIYYVRVRQDVLAGSEQYDEDSLVTAPGASDETTTECHSCMI"
     gene            complement(6544..7296)
                     /locus_tag="VHC05_001582"
     CDS             complement(6544..7296)
                     /locus_tag="VHC05_001582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ADP-ribosyltransferase"
                     /protein_id="HEQ5402871.1"
                     /translation="MLKKRYQLAMILLLSCFSLIWQTEGLVELFICEHYERAVCEGTP
                     AYFTFSDQKGAATLIKKRWGKGLVYPRTEQEAMAAYTCQQASLINTSLDKTKGELSQL
                     TPELKDQVAQLDAATHRLVIPWNIVVYRYVYETFLRDIGVSHADLTSYYRNHQFDPHI
                     LCKIKLGTRYTKHSFMSTTALKNGAMTHRPVEVRICVKKGAKAAFVEPYSAVPSEVEL
                     LFPRGCQLEVVGAYVSQDHKKLHIEACFKGSL"
     gene            7755..8249
                     /locus_tag="VHC05_001583"
     CDS             7755..8249
                     /locus_tag="VHC05_001583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402872.1"
                     /translation="MKTKKSKRFLNLATLCLALLGTTLLMGRPVKAEGSVVSDNSSGS
                     TSSLVDDSERDKIGRQYEAGDLTLPYNKGRYDGYIDGYEDGKKQGALHPDPTGDHLNK
                     LPKTIPYKFNDRSQKMNYEGGYSDSYPAGYYNGWADNNKIQATLEWLWGEISNWFSSI
                     FTTE"
     gene            complement(8854..9076)
                     /locus_tag="VHC05_001584"
                     /pseudo
     CDS             complement(8854..9076)
                     /locus_tag="VHC05_001584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429453.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3644 domain-containing protein"
BASE COUNT         2714 a         1975 c         1897 g         2490 t
ORIGIN      
        1 cctcctttga ttgactggtt ttgctgcccc ttaaaatatg atataataga ccattgatag
       61 ctgttactta acagaaggct gataaaaaag ttccattagc cttgagggtt gaatttaaac
      121 agggaaaaac gaaatcctac actatgcatc tcaatcgtac tttcatttga gtatggttct
      181 gaaaggaaac tatgatgaaa aaaccatttt acattacgac acccatttat tacccatctg
      241 ggaaattaca cattggttct gcttatacaa ctattgcttg tgatgtcttg gcacgctaca
      301 agcgcttgat gggccatgag gtcttttacc tcacagggct tgatgagcac ggacaaaaga
      361 ttcaaaccaa ggcaaaagaa gctggtatta cacctcaaac ctatgttgat aacatggcaa
      421 aggatgtcaa agccctttgg caattgctag atatttccta tgacacattt atccggacaa
      481 cggacgatta ccacgaagag gtcgttgctg ctgtctttga aaaattgctg gcgcaagacg
      541 acatttacct tggcgaatac tctggttggt attctgtctc tgatgaggaa tttttcactg
      601 aaagccaatt aaaagaagtc tttagagatg aagacggtca ggttattgga gggattgccc
      661 catcaggtca tgaggtcgag tgggtctctg aagaatccta cttcctacgc cttagcaaat
      721 acgctgatcg tcttgtggcc ttctttaaag agcgacctga ctttatccaa ccagatggtc
      781 gtatgaatga aatggtgaaa aactttatcg agccaggcct agaagatttg gctgttagcc
      841 gtactacctt tacatggggt gtacctgttc catcagaccc aaaacacgtg gtttatgtgt
      901 ggattgatgc cctcttaaat tacgcgacag ctcttggtta tggtcaagct aatcacgcta
      961 actttgataa attctggaat ggaacggttt tccacatggt tggaaaagat atcttacgtt
     1021 ttcatagcat ctactggcca atcttactca tgatgcttga tttaccaatg ccagaccgct
     1081 taattgctca tggttggttt gtcatgaaag acggtaaaat gtctaaatca aaaggcaatg
     1141 tggtctatcc agaaatgtta gtggagcgct ttggacttga tcctcttcgt tattacctca
     1201 tgcgttcttt gccagttggt tcagacggaa cctttacccc tgaagattat gtgggtcgta
     1261 tcaactatga gttagccaac gaccttggta atttattgaa ccgtaccgtt gccatgatca
     1321 acaagtattt tgatggcacg gtgccagctt atgttgacaa tggaactgcc tttgatgctg
     1381 acttaagtca actgattgat gctcagctag cagactacca taagcacatg gaagcggtgg
     1441 actacccacg cgccttagaa gccatttgga ccatcattgc tcgtaccaac aaatacattg
     1501 atgagacagc tccttgggtg ctcgctaaag aagatggtga caaggctcaa ctagccagtg
     1561 tcatggcaca cttggcagct agcttgcgcg tggtcgctca tgtgatccaa ccctttatga
     1621 tggaaacatc agctgctatc atggcccagc ttggcttagc gcctgtttct gacttgtcaa
     1681 cacttgctct agcagatttt cctgccaata caaaggtcgt tgccaaaggc acaccgattt
     1741 tcccacgtct tgatatggaa gctgagattg actacatcaa agcccaaatg ggtgacagct
     1801 cagctatttc ccaagaaaaa gaatgggtcc ctgaagaggt tgcgctcaaa tctgaaaaag
     1861 acgtcatcac atttgaaacc tttgatgctg tggaaatccg tgtggcagaa gtcaaggaag
     1921 tgtcaaaagt ggaaggttca gaaaaattgc tgcgctttag agtagatgca ggagacgggc
     1981 aagaccgtca aatcttgtca ggtattgcca aattttaccc caacgaacaa gaattagtgg
     2041 gcaaaaaact acaaattgtt gctaacctga aaccgcgtaa aatgatgaaa caatacatca
     2101 gccaaggcat gattttatca gcagagcatg gagatcagct aacggtctta accgttgatc
     2161 cctctgttcc aaatggaagt atcattggct gatgctgacc tattattcaa aaaacctaag
     2221 caagaacatg tgcttaggtt tttttgattg ccttcaagaa agacgaataa cgagatgggt
     2281 gatatgacat caaaagcata actatcctag gacctgtcct agtaagattg ctgtgctttt
     2341 gacaagtgaa cagagaggtc ttaaaactat atcttgtcat aaaaaagatt gcaaaacact
     2401 atatcttgtg ttattatggt ttttataaaa gttaagcatg cttaacttta gccaaacaaa
     2461 agaggacact agagcgtgtc ccacaagaca gttgagccct tcgctttttt agtagagtag
     2521 gagtgctcaa gtcaaaaaga gacatcccat caaaccattg ctgtttagca ggtctttttg
     2581 tgttgctcaa aaaaacagtt cctgtctgtt tggcgtctag tgatgactta ggcttagcgc
     2641 tactagactt ttgtttgaaa aatacctcaa gccttgaagg agacaaatga cccaatatta
     2701 ttatgaacgt tcgcaatccc caattgaata cgccctatct gaaacacaaa aacagttgcg
     2761 ctccatcaat tggaattacc ttaatgatga caaagatttg gaagtgtgga accgtgtcac
     2821 tcaaaatttt tggttgcctg aaaaggttcc tgtttctaat gatttaaatt cttggcgctc
     2881 cttgggtgag gattggcaac agctcatcac aaggacctac actgggttga ccttactaga
     2941 tacagtacaa gcaacggttg gtgatgtggc acaaattcag cattcacaaa ccgaccacga
     3001 acaagtcatc tatacgaact ttgcctttat ggtggggatt catgcccgct cttacgggac
     3061 gattttttcg accctttgca gcagtgagca aatcgaagaa gcacatgaat gggtggtctc
     3121 aacacagagc ttgcaagacc gtgcccgtgt cttgattcct tactatacgg gtgatgaccc
     3181 tttgaaatca aaagtagcag cagctatgat gccaggattt ttgctgtatg gcggctttta
     3241 ccttcctttt tacctatcag cacgtggtaa aatgccaaac acctctgata tcatccgtct
     3301 gattttacgc gacaaagtta ttcacaacta ttacagcggt tacaaatacc aacaaaaagt
     3361 agcacgtctt agcccagaaa aacaggctga aatgaaggcc tttgtctttg acttgctcta
     3421 tgaactcatc gaccttgaaa aagcttactt gagagaactg tatgcaggct ttgatttggc
     3481 agaagatgct atccgcttta gcctttataa cgctggaaaa ttccttcaaa atttgggata
     3541 tgagtcgcca tttacagaag aagaaacgcg cgtttcacca gaagtatttg ctcagctatc
     3601 agcgcgtgca gacgaaaacc atgacttttt ctcaggcaat ggctcatctt atgtgatggg
     3661 gatcaccgaa gaaaccacag atgacgattg ggagttttaa gaaatggcag agctgattat
     3721 tgtgtatttt tcatctaagt ccaataacac ccatcgcttc gtccaaaaat taggcctgcc
     3781 tgctcagcgc ataccagtag ataataggcc acttgaagtt tcaacccatt accttttgat
     3841 tgtgcctacc tatgcagctg gtggctcaga tgccaaagga gccgttccta aacaagtgat
     3901 tcgttttttg aataatccta acaatcgtaa acattgtaag ggagtgatct cttcaggaaa
     3961 taccaatttt ggcgatacct ttgccttagc aggccctatc atttctcaaa aattgcaggt
     4021 ccccttatta caccaatttg aactattagg cactgctaca gatgttaaaa aggtacaggc
     4081 gatttttgcc cgcttaaagc atcacacaca cgacaagcaa aacaaaccaa caacctgatt
     4141 acagaaagga cacacccatg tcacaaacca atgcgtcata cctctcatta aatgcactga
     4201 ctcgttttaa aaaaccagac ggcagctacc attttgatag cgataaagaa gctgttaggc
     4261 gctacctgga agaacatgtc tctcccaatc aaatggcttt taactcacta gaagataagc
     4321 tagcttacct catcaatgaa gggtattatg agcaggccat ttttgatgcc tatcctaacg
     4381 accttatcaa ggaggccttt cattatgcct atcaacaagg ctatcgcttt ttaaatctca
     4441 tgggcgctat gaaattttac cagtcctatg ccttaaaaac cttggacggt aagcattacc
     4501 tagaaacatt tgaagaccgt gctgtgatga atgcactctt tttagctgat ggagatcaaa
     4561 cctttgtctt tgacgtgatt gatgccatct tgcaccgacg ctttcaacca gctaccccaa
     4621 cctttttaaa tgccggaaaa aaacgccgtg gcgaatacat ttcgtgctat cttcttcgtg
     4681 tcgaagacaa tatggaatct atctctcgcg ccattagcac cagcttgcaa ctctcaaaaa
     4741 gaggaggcgg agtcgccttg tgcctcacca acctcagaga aatcggagca ccgataaaag
     4801 ggattgaaaa tcaggcaaca ggtatcgttc ctgtcatgaa actactagag gactcttttt
     4861 cctatgccaa tcaactaggt cagcgccaag gagcaggtgc ggtttacctt catgcccatc
     4921 accccgaggt cctgaccttt ttagacacca aacgtgaaaa tgccgatgag aaaattcgca
     4981 ttaagtccct agcattggga cttgtgatcc cagatattac cttccagtta gccaaagaaa
     5041 acaaagacat ggctctcttt tcaccctatg atattaagcg tgcctatggc aaggacatgt
     5101 cagacatctc catcacagag gaatacgata aactgctagc caatccggcc atcaaaaaga
     5161 cctacatcag tgctagaaag ttctttcagt taattgcaga gctacatttt gagtcaggct
     5221 acccttacct cttgtttgat gacacggtca ataagcgcaa ccctcatgcc aaaaaaggca
     5281 gaatcgtcat gtctaacctg tgttctgaaa tcgctcaagt cagcacccca agcactttca
     5341 aagaagattt gagttttgaa accattggag aggatatctg ctgtaattta gggtctatca
     5401 atattgccca ggctatggca gatgcgccac actttgaaca gctcatcaca acgagcatca
     5461 gagcacttga tcgtgtctct agactgtctg acctgaattg tgcgccttct gttgagacag
     5521 gcaatgcagc caaccatgca gtaggattag gcgccatgaa cctacatggg tttttggcaa
     5581 ccaaccacat ctactatgat acaaaagaag ccgttgactt tacagatctg tttttccatg
     5641 ccatggccta ttatgctttt aaagcctctt gccaactagc caaagaaaaa ggcgcttttg
     5701 caggattttc gttatcaacc tatgcagatg gcacttattt tgccaagtat ttgcaagaag
     5761 atgccaagcc acaaacagcc aaggttgcca cattgttgca agattacggc ttcacattgc
     5821 caacggtggc ggattggcaa gctctagtag cagatatcaa gcagtttggc ctagccaatg
     5881 cgcacttgct agcggttgct ccgacaggct ccatcagcta cttatcatca tgcactccga
     5941 gtctacaacc agtcgttgct cctgttgagg tccgaaaaga aggtagcctg ggcaggattt
     6001 acgtccctgc ctatcagatt gaccaggcta actatgctta ctatgaacgt ggtgcctatg
     6061 aggtcggccc aaaagccatc atcgacgttg tcgctgctgc ccaaaaacac gttgaccaag
     6121 ccatctcatt gaccctgttt atgaccgatc aagcgaccac acgtgacctt aaccgctcct
     6181 atatccaagc ttttaagcaa aactgtgcat cgatctatta tgtgcgagtg aggcaagacg
     6241 tcctagcagg cagcgaacag tatgacgagg atagtcttgt gacagctcct ggagctagtg
     6301 atgagaccac cacagagtgt catagctgta tgatctaaca gctactagaa agctctcgtg
     6361 tcccctacca catgcatagg atcagtgcgc tcgacctttc aagacaagca agcatcagct
     6421 cttgcttgtc tttttttggc ctcaaagccc gttagtctgc tgctatgcga ggcttttttt
     6481 gagcatcaga acctcaaaaa aaaggacatg gagtcctttt tggggtgatc ggtgttgagg
     6541 ccgtcacaaa ctgcccttga agcacgcttc tatgtggagc tttttgtggt cctgtgacac
     6601 gtaagctcca acgacctcca gctgacagcc tcttggaaac aagagctcaa cctctgaagg
     6661 cacagccgaa taaggctcga caaaggctgc tttggcccct tttttgacac agatgcgcac
     6721 ctccaccggt cgatgggtca tagcgccgtt tttcaaggct gtcgtgctca taaaactgtg
     6781 cttagtgtag cgtgtgccaa gcttgatctt acaaaggata tgagggtcaa actgatggtt
     6841 acgatagtaa gacgtgagat cagcgtgtga aacaccgata tcacgcaaaa acgtctcgta
     6901 tacatagcgg tataccacaa tgttccacgg gatgactagc cggtgagtcg cagcatcgag
     6961 ctgggccacc tgatccttta gctcaggcgt gagttggctg agctcacctt tggtcttgtc
     7021 taggctggta ttgataaggc ttgcctgctg acaggtataa gcagccatcg cctcttgctc
     7081 agtccttggg tagacaagac ccttgcccca tcgcttttta attagtgtcg cagcgccctt
     7141 ttgatccgaa aaggtaaaat aagcaggcgt cccctcacaa accgcccgct catagtgctc
     7201 acagataaaa agctcgacca agccctcagt ttgccagatc agactaaaac agctaagaag
     7261 aaggatcata gcgagttgat agcgcttttt tagcatagtt ccccctgaca ccagcccaaa
     7321 aggctgcccc ttcccctaga gcttttggct agctcttgac accaccagtt tctcagacag
     7381 gctaatcttt ttgtcatctc tttctcccta aacagactct cttatcatga tattatgcta
     7441 ttatgagcga tttgtcaatc catagcaacc gttttttagc cagataagca agcttttgac
     7501 ctataggcag acaagagtgg cagtacctac cgttcactgt ggtggctgat aagaactaac
     7561 ataaaatctc aaacgctttc aaaaacagct cctgagctta aaaaaggctg atgaacaatt
     7621 tttttgagtt taagagagat tgccataatt ttctaatcat ttgatgatta aaatgataaa
     7681 aacatgaact tgaaatgaag gagtgcgagt agtaaactat aatcgtatca aaaataatga
     7741 aatggggtaa ttttatgaaa acaaaaaaat caaaacgctt tttaaaccta gcaacccttt
     7801 gcttggccct actaggaacg actttgctaa tgggacgtcc cgtaaaggcg gagggaagtg
     7861 tagtttcaga caattcatcc ggatccactt cttcgctagt ggatgatagt gaaagagata
     7921 agattggtag acaatatgaa gcaggagatc taacattgcc ttataataaa gggagatatg
     7981 atggttatat agacggctac gaagatggta aaaaacaagg agccctgcat ccggatccta
     8041 ctggtgatca cttaaataag ttacctaaaa ctattcctta taagtttaat gatagaagtc
     8101 agaaaatgaa ttatgagggt ggctatagtg atagttatcc tgcaggatac tataatggtt
     8161 gggctgataa taacaaaatt caagcgactt tagaatggtt atggggtgaa ataagcaatt
     8221 ggttttctag tatatttaca actgaatagt ctatcatctt actaaagcga ttttcatttt
     8281 ttatactaac tatagtagtt agttcaaaaa agctgattaa cagcctaaaa caaactcttt
     8341 ctctgacaag aaaaagcgtt atgctttccg aaccattttg tcttttaaat aataaaaaat
     8401 gagcttgaaa tgaacttgaa atgaaacagt gagaggtaag agatataaaa taagatcgtc
     8461 gaaaataaag aaacggagta atttttatga gaacaaaatc caactacttt ttaaacttag
     8521 caactctttg cctagctctt tttggagcaa ttttactaat ggcacaacca gcaaatgctg
     8581 aggaagtatc tccaaacatt ggagttgagg gtacttctta gtattatggt gaaatgcagg
     8641 gagaatatga tgaggaagca gagctctctt caaaagatag agaattcggg agacaaaatg
     8701 gtcaaaaaga tggcaaagag ggtaaaaatg gatttggccc aacaataaat cgagatgata
     8761 tacaagttcc tgaaaaagta aaacatcaag atgaatatca ggatgggtat gaacaaggtt
     8821 atcgtgaggg atggcagcag gagcatccac ttctatcttt tttaaaacat attctaggct
     8881 caatgttctt tctggattat cactgtaata aatactaaac cctcggttaa gcatctcagc
     8941 ttttagcatt agttcccaag cattacatat aaaaaaacta aagccttcaa ttcgatattt
     9001 tattgtcggc ttattatata tttcaagccc cataataaaa gcttcgatac tttttaaaac
     9061 taatctttca cttaaa
//
LOCUS       DAUDWO010000054         7948 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.055, whole genome shotgun sequence.
ACCESSION   DAUDWO010000054 DAUDWO010000000
VERSION     DAUDWO010000054.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7948)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7948)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7948
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.055"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(14..793)
                     /locus_tag="VHC05_001585"
     CDS             complement(14..793)
                     /locus_tag="VHC05_001585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HEQ5402873.1"
                     /translation="MKTPEQILEATIHIGEHKVTKTFLAKSILGFIGGAMISLGYLLY
                     VRIAASGLETFGAFSSIVGACAFPIGLIIILMAGGELITGNMMAVSAALLAKKIKFSE
                     LAKNWLIITLFNVIGAVFVAFVFGHFLGLTSAGIFKEEVIEVAHAKIAASPLQALVSG
                     IGCNWFVGLALWLCYGANDAAGKFLGTWFPVMTFVALGFQHSVANAFVIPAAIFEGGA
                     TWLDFVTNFIFVYSGNIIGGAIFVSFLYFKVYYHPQKSKTQ"
     gene            complement(917..1459)
                     /locus_tag="VHC05_001586"
     CDS             complement(917..1459)
                     /locus_tag="VHC05_001586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402874.1"
                     /translation="MTKKPTQLIAYTSILVAFAILIPIIMPLKLIIGPASFTLASHVP
                     LFLAIFMSIPVAILVALGTTLGFLLAGLPLIIVLRALSHLLFAILAAWWLSRKPQLMT
                     SAVKCFSFAFFINVIHGLAEFLVVYILTATTATSMSYFWSMLGLIGLGSLIHGILDFY
                     LALVLWRFLAKNLKLPTINA"
     gene            complement(1620..2141)
                     /locus_tag="VHC05_001587"
     CDS             complement(1620..2141)
                     /locus_tag="VHC05_001587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription repressor NadR"
                     /protein_id="HEQ5402875.1"
                     /translation="MKAEDRRQKIIECLNSEQKAVSATRLGKLLGVSRQVIVGDIALL
                     RAQQIDIISTPKGYIMSTALYSHQFCARIVCQHNVEETKKELEIILAHQGIITTVEVE
                     HPIYGMITAPLNIKTHSDVTNFMSKLSQSKAELLSSLTEGLHSHLISCPSQEAFLAIK
                     HDLELAGILYKGI"
     gene            complement(2249..2944)
                     /locus_tag="VHC05_001588"
     CDS             complement(2249..2944)
                     /locus_tag="VHC05_001588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051611.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate mutase"
                     /protein_id="HEQ5402876.1"
                     /translation="MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIK
                     EAGIEFDLAFTSVLTRAIKTTNLALENAGQLWVPTEKSWRLNERHYGALTGKNKAEAA
                     EQFGDEQVHIWRRSYDVLPPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAM
                     PYWEEKIAPALLDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDE
                     KLNIVKEYYLGGE"
     gene            3183..4118
                     /locus_tag="VHC05_001589"
     CDS             3183..4118
                     /locus_tag="VHC05_001589"
                     /EC_number="1.3.98.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004228450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate oxidase"
                     /protein_id="HEQ5402877.1"
                     /translation="MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVT
                     KTGTLEVRPGNPEPRYADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKPHFLSVV
                     GLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTK
                     PLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGI
                     GGDYIKPTALANVHAFYKRLKPSIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQE
                     GPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD"
     gene            complement(4418..6280)
                     /gene="cadA"
                     /locus_tag="VHC05_001590"
     CDS             complement(4418..6280)
                     /gene="cadA"
                     /locus_tag="VHC05_001590"
                     /EC_number="7.2.2.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cadmium-translocating P-type ATPase"
                     /protein_id="HEQ5402878.1"
                     /translation="MTIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITA
                     FLIGGYASAKTGILDLVKNKHLSVDILMILAAIGAGIIGYWLEGALLIFIFSLSNTLE
                     EMAMEKSKDAISALMSLTPDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQ
                     LLSPFGQFDESMVTGEPITVDKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINL
                     VESAQEKKSKTATFIESLEDGYVKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTV
                     ASPCALIASSTPASLAAISRAARKGLIIKGGDIVDNMGDIKAVVMDKTGTLTQGKPSV
                     VNAHYLEDELLVNRLVKGAEAASTHPISKALLEYTEKLEPLTFDHLEEISGKGFQGFY
                     QGQEWRIGKKTFILEKVQDLSAFEETIQVEENQGKTLIFVSRDHQLIAYYALLDDIKI
                     ESKRAIKSLHAMGIKTVMLTGDQERTANYVAQKLGIDEVVANCMPQDKVAKLAELKTK
                     YGFVAMVGDGINDAPALAQADVSYAIGSGTDIAMESADSVIMDDLTRIPFSIQLSRKM
                     KTIIKQNIVFALSVITLLILANIFQVVNLPLGVVGHEGSTILVILNGLRLLSFK"
     gene            complement(6811..6993)
                     /locus_tag="VHC05_001591"
     CDS             complement(6811..6993)
                     /locus_tag="VHC05_001591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Paratox"
                     /protein_id="HEQ5402879.1"
                     /translation="MLTYNEFKQAIDNGYIAGDTVAIVRKDGQIFDYVLPHEKVKNGE
                     VVTKEKVEEVLVELSR"
     gene            complement(7106..7888)
                     /gene="entC3"
                     /locus_tag="VHC05_001592"
     CDS             complement(7106..7888)
                     /gene="entC3"
                     /locus_tag="VHC05_001592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enterotoxin type C3 EntC3"
                     /protein_id="HEQ5402880.1"
                     /translation="MNKRIRILVVACVVFCAQLLSISVFASSQPDPTPEQLNKSSQFT
                     GVMGNLRCLYDNHFVEGTNVRSTGQLLQHDLIFPIKDLKLKNYDSVKTEFNSKDLAAK
                     YKNKDVDIFGSNYYYNCYYSEGNSCKNAKKTCMYGGVTEHHRNQIEGKFPNITVKVYE
                     DNENILSFDITTNKKQVTVQELDCKTRKILVSRKNLYEFNNSPYETGYIKFIESSGDS
                     FWYDMMPAPGAIFDQSKYLMLYNDNKTVSSSAIAIEVHLTKK"
BASE COUNT         2578 a         1599 c         1281 g         2490 t
ORIGIN      
        1 aaaaaatatt ttctcattga gttttactct tttgcggatg atagtaaact ttaaaatata
       61 aaaaactaac aaaaatggct ccaccgataa tattaccact atagacaaaa ataaaattag
      121 tgacaaaatc caaccatgtt gctcctcctt caaaaatagc agcaggaatg acaaaagcat
      181 ttgctacact atgctgaaaa ccaagggcta caaaggtcat gacaggaaac caagtaccaa
      241 ggaatttacc agcagcatca tttgccccat agcatagcca caaggccaaa ccaacaaacc
      301 agttacaacc aattcctgat actagtgcct gcaaagggct cgctgctatt ttagcatggg
      361 ccacctcaat cacttcttct ttaaaaatac cagctgatgt caagcctaga aaatgaccaa
      421 acacaaaagc tacaaaaaca gctccaatca cattaaacaa ggtaatgata agccaattct
      481 tggcaagctc gctaaactta atttttttgg ccaacaaagc tgcagaaaca gccatcatgt
      541 tccctgtaat taattctcca cccgccatta aaataataat tagaccaatc ggaaaagcac
      601 aagctcctac gatactggaa aaagcaccaa aagtttctaa accactggcg gcaattctca
      661 cgtagagtaa ataaccaagg ctaatcatcg ctccaccaat aaagcctaag atagatttag
      721 ccaaaaaagt tttggtaacc ttatgttccc caatatgaat agttgcttct aaaatctgtt
      781 ctggtgtttt catgatatct ccttttgtta ctgtattcac aaacacacac tttagtatat
      841 caattttcct aaaaaatgca agccctttca acaagaaagg gctcgtcatt atcatataac
      901 tatctctatt ttagtcttag gcatttatgg tgggaagttt taagtttttt gctaaaaaac
      961 gccatagaac taaagcaaga tagaaatcca atatgccatg aataagcgaa cctaagccaa
     1021 tcaagcctag catagaccaa aaataagaca tagaagttgc tgtggttgct gttaaaatat
     1081 agacaactaa aaattcagcc aagccatgaa tgacattaat gaaaaacgca aaactaaaac
     1141 attttactgc cgatgtcatc agttgtggtt ttctacttaa ccaccacgct gccaaaatag
     1201 caaacaataa atgagagagt gctcttaaaa caataattaa aggaagtcca gctaataaaa
     1261 aacctaatgt ggtaccaaga gcgaccaaaa ttgctactgg aatcgacata aaaatagcca
     1321 aaaacaaagg aacatggctc gccagagtaa aggaagctgg cccaataata agcttaagag
     1381 gcatgattat cggaatcaaa atcgcaaatg cgaccaaaat agaggtataa gctattaatt
     1441 gtgttggttt tttagtcatt ttatctcctt ttcaaaaata gtatacctta aaaaccaata
     1501 actatcaaga cacctgtatc ttttggtatt tttaaacggt accttgttgc tgataaataa
     1561 tcaatagaat attttagcat ggtattcata acaaccatca atggcataat atactgtagt
     1621 tatattcctt tgtataagat acctgctaat tctaaatcat gcttgatagc taaaaaggct
     1681 tcttgactag gacacgaaat taagtgacta tgtagtcctt ctgtcaacga agacaataac
     1741 tctgctttag attgactgag tttggacatg aaattagtta catcagagtg tgtcttaata
     1801 tttaaagggg ctgttatcat accgtaaata ggatgttcta cctctaccgt cgtaataatc
     1861 ccttgatgag ctaaaataat ttctaattct tttttagttt cttctacatt atgttggcac
     1921 acaatacgtg cacaaaattg gtgactataa agcgctgttg acataatata accttttgga
     1981 gtcgaaataa tatcaatctg ctgagctcga agaagagcta tatctccaac aattacttgg
     2041 cgactcactc ctaataactt acctaaacga gtagcagata cagctttttg ttcactattt
     2101 aagcactcaa taattttttg acgacgatct tctgctttca taatctatct atcctttttt
     2161 atttctatca tatcatattt ttaagcaggg ttttctttct tcttaggata tagaacccaa
     2221 aaaaccagac caaagtctgg tttttaagtt attcaccacc aaggtagtat tctttaacaa
     2281 tgttaagttt ttcatctaat tcaaaaacaa gtggtgggaa gtttggaatt tccacatcca
     2341 tgatttcgtc atctgaaaga cctttaatgt gtttcacaag agcgcggatt gagttaccat
     2401 gtgcaccaac aaagacgttt ttaccgtcaa gaagagctgg agcaattttt tcttcccagt
     2461 aaggcattgc gcgttcaaga gttactttta agttttcagc atctggaata agggctgggt
     2521 caagatcagc ataacgacgg tctttgtgtg ctgaatactc atcatcttta gccatagctg
     2581 gcggcaacac gtcgtatgaa cgacgccaga tatgaacttg ttcatcacca aattgttctg
     2641 cagcttcagc tttgtttttg ccagtcaaag caccatagtg acgctcgttc aagcgccatg
     2701 atttttcagt tggaacccac aattgacctg cattttcaag ggcaaggtta gttgttttga
     2761 tagcacgtgt caatactgaa gtgaaagcaa ggtcaaattc aatacctgct tctttgatca
     2821 atttacctgc atcaatcgct tgttgtgtcc ctttttctga aagatcaaca tctgcccaac
     2881 cagtgaagag gttagctttg ttccattctg actcaccgtg gcgagcgaaa accaatttta
     2941 ccatgagtta atatctcctt ttaatttaaa ggttgctacc tttttacaat tcctatttta
     3001 caaaaaatat agcaaaaaag ctagtctatt ctgactttat tgaaaatcat aatgtgacta
     3061 tcatgaaaat ttcaaatgtt cgttaataac agtaatatat ttacattttt gtaaaaatag
     3121 cttgctatta ttcatgccta gtggtagaat agaaaaaatt tgtctaaaat atggaggaaa
     3181 taatggtttc tactgctaca caaattggtc atttctcttt tgataactgt ttgatgaatg
     3241 ctgctggtgt ttactgcatg acaaaagaag agcttatgga ggttgaaaag tctcaagccg
     3301 cttcctttgt caccaaaaca gggacgcttg aagttcgtcc aggtaatcca gaacctcgct
     3361 acgcagatac tcgtcttggt tctatcaatt caatgggact ccctaataat ggttttcgct
     3421 actacttaga ctttgtcagt gatcttgcca aaaccgggca acataaacct cactttctct
     3481 ccgttgtcgg gctatctcct actgaaaccg aaaccatttt aaaagccatc atggcttcag
     3541 attatgaggg tctagtggaa ctaaaccttt cttgccctaa cgttccagga aaaccacaga
     3601 ttgcttatga ttttgaaacc actgatcaac ttctagagaa catctttacc tattacacta
     3661 aacctcttgg tatcaaatta cctccttatt ttgacattgt gcattttgat caagcggctg
     3721 cgattttcaa taaatacccc ctttcctttg ttaactgtgt caattctatc ggaaatgggc
     3781 tggtcattga ggatgagcaa gtcctcatca agcctaaaaa tggctttggt ggtataggtg
     3841 gagattacat caaacctact gctctagcca atgtccatgc gttttacaaa cgcttaaaac
     3901 cttctatcca cattattggt acagggggag ttaaaacagg acgcgatgcc tttgaacata
     3961 ttctttgtgg cgccagcatg gtccaaattg ggacagccct tcatcaagaa gggccagcta
     4021 tctttgaacg ggtcactaag gaactaaaaa cgattatggt agaaaaaggc taccaaagct
     4081 tagacgattt tcgtgggaac ttacgttaca aagattaacc ttaatagtca aaaaagcttg
     4141 gaaatgtgca ctttgtacac tttccaagct ttttaaaatg ggaatttttt tgaagggaca
     4201 gcgtcacttt cttgggactg tctttgctgg ttgtttgatt caacttttct tttttgcttg
     4261 cgctcaaatt gctgataaaa atagaaaaat agaatgattt taattattga aaatacagct
     4321 aaaccaatga tcataatagt aaacatacgg cggttttctc tttcataagt cttactatta
     4381 ttataaacac tttcaagttt tcaagcaagt ttctaaatta tttaaaagaa agtaaacgca
     4441 agccatttaa aatcactaaa atcgttgagc cttcgtgtcc aacaacacca agcggcaagt
     4501 taactacctg aaaaatattg gctaaaatca ataaggtaat cacagataag gcaaaaacaa
     4561 tattttgttt gataatggtc ttcattttgc gggaaagttg aatcgaaaat ggaatacgag
     4621 tcaagtcatc cataatcaca ctgtctgcac tttccattgc aatatctgtt cctgatccaa
     4681 tagcataaga aacatctgct tgagcaaggg caggagcatc attaatacca tctcctacca
     4741 tagccacaaa accatattta gtctttaatt ctgctaactt agccacctta tcttgaggca
     4801 tacagttggc taccacttca tcaataccaa gtttttgtgc cacataattg gcggttcgtt
     4861 cttggtcacc tgttaacatg actgttttga ttcccatggc atgaagagac ttaatagcac
     4921 gttttgattc tattttgata tcatccaaga gggcatagta agctatcaat tgatggtcac
     4981 gtgaaacaaa gattagggtt ttcccttgat tttcttccac ttgaatagtt tcttcaaaag
     5041 ctgataggtc ttgaaccttt tccaaaatga aggttttctt gccaattcgc cattcttgcc
     5101 cttgatagaa gccctgaaaa cctttcccag aaatttcttc taagtggtca aaggtcagtg
     5161 gctccaactt ttcagtgtat tcaagaaggg ctttagaaat aggatgggta ctagcagcct
     5221 ctgctccttt taccagtcta ttcacgagca actcatcttc caaataatga gcattcacaa
     5281 cagaaggttt tccttgggtg agcgttcccg ttttatccat gacaacagcc ttaatatctc
     5341 ccatgttatc gacaatatcc cctcctttga taatcaatcc ctttctggct gcacgagaaa
     5401 tagcagccaa gctagcaggt gtggaactgg caattagggc acatggtgaa gctactgtta
     5461 agagaatcat ccctcggtaa aaagcagcca accaagtcca agaaagcaca aagtgactaa
     5521 agaggataaa ggcaggaata aggacgagca caaatttgac ataaccatct tctaagcttt
     5581 cgataaaggt ggcggttttg cttttctttt cttgggcaga ttccaccaga ttaataatct
     5641 tggcaaagag agtatcgtca ttttcaatag taaccaacat atctatggtt tgtccttggt
     5701 taatggttcc cccaatcaga tcctggcctt ctgccttatc aacagtgata ggctcaccag
     5761 tgaccataga ttcatcaaat tgaccaaaag gactaagcaa ctgcccgtca attggaacag
     5821 cttcgccttt acgaacttgt aaacggtcac caacactcaa ggatctggtc tcaacttcta
     5881 aaatatggcc atcttcttgg tattgacgag ctgtatctgg cgtcaaggac atcaaggctg
     5941 aaatagcatc cttacttttt tccatggcca tttcttcaag cgtattggac aacgaaaaga
     6001 taaaaataag cagagcaccc tccagccaat agccgataat tccagcaccg atagctgcca
     6061 aaatcatcaa aatatccact gacaagtgtt tgttcttcac caaatccaat atacccgttt
     6121 ttgcagacgc atatcctcca atcaagaagg ctgtaatgaa aatagcggaa gccacttgtg
     6181 gaaatgagtg taaaaaggct aggccaatta ttattaatac caaacacgct aaagtctcca
     6241 tcaaatgaag atggtctgcc atccattgtc tgattgtcat ttttagttcc ctcgcaatta
     6301 aaagttattc aatctttaag atatattaat tataataatt ctaaataaat aagtcaagta
     6361 atttagaaac attctaaata aactttttta aacttacctt ttgctttcaa aaatcctaac
     6421 ttcaactatt tgcaaatatg aaaaaaactc cccctacctg cggaaatgat atactaatag
     6481 aaggatgact gaccattata gagtgcatgc tttagaactt ggcttaactg aagagaaaac
     6541 tactaacttt atgccccaaa tataaaaaaa gaaccttgtc gctatcaata aacatcgata
     6601 gcaacaagat ttttctagac gaattattta acagcgtctt ttaaagatta cttaatattg
     6661 tgcacatata atataataaa ctttgatttt ataaagctac aaaataacga aactttatat
     6721 aattgcttcg aatcaactat gtaagtttta aacttatgcc ccctatttac ccctttaata
     6781 aaactacttc tcagggggca aagaaaatac ttatctcgaa agctccacca gcacctcttc
     6841 cactttttcc ttagtcacaa cttctccatt ctttactttc tcatgtggca acacataatc
     6901 aaaaatctgt ccgtctttac gcacgatcgc tactgtatcg cctgcgatat atccattgtc
     6961 aatcgcttgc ttaaactcgt tgtatgttag catttttact ctcctactta tttattcgta
     7021 ttctcatagc ttaaattaac tttttagtat caatcatttt gaatttaact agtatcatgg
     7081 atttgataca taaagttatt ttcttttatt ttttggtaag gtgaacctct atagctatag
     7141 ctgaagagct cactgtctta ttatcgttat atagcattaa gtatttagac tgatcaaata
     7201 ttgctccagg tgcgggcatc atatcgtacc aaaaactgtc tcctgagctc tctataaatt
     7261 taatatagcc tgtctcgtac ggagaattat tgaactcata caaatttttt cgagacacta
     7321 atatttttct ggttttacaa tctaattctt gaacagtgac ttgtttttta ttagttgtaa
     7381 tatcaaacga aagtatattt tcattatctt cataaacttt tactgtaata ttcgggaact
     7441 taccttcaat ttgatttcta tggtgctcag taacacctcc gtacatacaa gtttttttgg
     7501 catttttaca actatttcct tccgaataat agcagttata gtagtaattg gaaccaaaaa
     7561 tatctacatc tttattttta tattttgcag ctaaatcttt actattaaac tctgttttta
     7621 ctgaatcata gtttttaagt ttcaaatcct taatgggaaa aatcaaatca tgctgtaaaa
     7681 gctgacctgt ggatcttaca ttagtccctt ctacaaaatg gttatcatat aaacatctca
     7741 aattacccat aacaccagta aattggctag atttgtttaa ttgttctgga gtagggtcag
     7801 gctgactact tgcaaaaaca ctaatcgata ataattgtgc acaaaaaact acacatgcta
     7861 caacgagtat tcttattctt ttattcattt ggctacctct tatatattta aaacgttata
     7921 tagattataa cgttaacttt tcatctcc
//
LOCUS       DAUDWO010000055         7870 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.056, whole genome shotgun sequence.
ACCESSION   DAUDWO010000055 DAUDWO010000000
VERSION     DAUDWO010000055.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7870)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7870)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7870
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.056"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..672
                     /locus_tag="VHC05_001593"
     CDS             <1..672
                     /locus_tag="VHC05_001593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2142 domain-containing protein"
                     /protein_id="HEQ5402881.1"
                     /translation="TYFLLVCLPLFIPNEKFGKNTKLVILKKLGGLLLIFLFAAMWFR
                     LYGQVKTPYVADFLKEVNVSQQVKNMLESPIVYSSIIIRHMVINLINMNNIFQFGALS
                     YGITNLFPLYVCFFFFVYISNASKITINIVEKMGIIFVISAIIGATVLAMYLTWTPVG
                     SSTVLGVQSRYLIGIIPLVLLLFSSQQQKFKQIEDILSDKLAIHISLLFILAMLMSTI
                     FRYYH"
     gene            766..1989
                     /gene="pepT"
                     /locus_tag="VHC05_001594"
     CDS             766..1989
                     /gene="pepT"
                     /locus_tag="VHC05_001594"
                     /EC_number="3.4.11.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase T"
                     /protein_id="HEQ5402882.1"
                     /translation="MKYDNLLDRFIKYVKVNTRSDPDSETTPSTESQEAFALTILKPE
                     MEAIGLQDVHYNPVNGYLIGTLPANNPTLTRKIGFIAHMDTADFNAENVNPQIIDNYQ
                     GGDITLGSSNYKLDPKAFPNLNNYIGQTLITTDGTTLLGADDKSGIAEIMTAIEFLTS
                     QPQIEHCDIKVAFGPDEEIGVGADKFEVADFEVDFAYTMDGGPLGELQYETFSAAALE
                     VTFLGRNVHPGTAKDQMINALQLAIDFHEKLPAKERPEYTDGYQGFYHLTGLTGTVEE
                     ARASYIIRDFEEASFEARKVKVENIAQSMNAQLGTKRVLVELNDQYYNMKKVIEKDMT
                     AIELAKEVMEELTIKPVIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEFVSLQT
                     MERAVDVIIGLVCKA"
     gene            2030..2518
                     /locus_tag="VHC05_001595"
     CDS             2030..2518
                     /locus_tag="VHC05_001595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EbsA family protein"
                     /protein_id="HEQ5402883.1"
                     /translation="MIKLFGKIRYHWQPELSWSIIYWSIAFAPIFVGLSLLYERTEIP
                     SRVFILFAIFAVLVGIGLHRYFIIENNGILRIVSFKLFGPRKLLISTITKIEVTKSTL
                     CLHVEDKSYLFYMRKWPKKYFLDALAVNPYFQGEVILSDNFIKLDYFEVYQHDKKALT
                     RG"
     gene            complement(2505..2702)
                     /locus_tag="VHC05_001596"
     CDS             complement(2505..2702)
                     /locus_tag="VHC05_001596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HEQ5402884.1"
                     /translation="MKVSIIPEKCIACGLCQTYSSLFDYHDNGIVTFSSSSETSQSIC
                     PSDKDAILAVKSCPTKALTLE"
     gene            2751..3227
                     /locus_tag="VHC05_001597"
     CDS             2751..3227
                     /locus_tag="VHC05_001597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HEQ5402885.1"
                     /translation="MAKEPWEEKIVDDTIGTRTRKSRNAFISTPWLTALLSVFFVIIV
                     AILFIFFYTSNSGSNRQAETNGFYGASTHKKTRKASNAKKTSSSSTTTDTTPSSEEIL
                     ASSEGTGETLTVLAGEGAASIAARAGISVEQLQALNPEHMTQGYWYANPGDQVTIK"
     gene            3242..3922
                     /locus_tag="VHC05_001598"
     CDS             3242..3922
                     /locus_tag="VHC05_001598"
                     /EC_number="2.7.4.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(d)CMP kinase"
                     /protein_id="HEQ5402886.1"
                     /translation="MKAIKIAIDGPASSGKSTVAKIIAKNLGYTYLDTGAMYRSATYI
                     ALTHGYTGKEVALILEELEKNPISFKKAKDGSQLVFLGDEDVTLAIRQNDVTNNVSWV
                     SALPEIREELVHQQRRIAQAGGIIMDGRDIGTVVLPDAELKIFLVASVEERAERRYKE
                     NLEKGIESDFETLKEEIAARDYKDSHRKVSPLKSAEDALIFDTTGVSIDGVVQFIQEK
                     AEKIVDMS"
     misc_feature    3946..4069
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00558"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L20 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00558"
     gene            4084..4614
                     /gene="infC"
                     /locus_tag="VHC05_001599"
     CDS             4084..4614
                     /gene="infC"
                     /locus_tag="VHC05_001599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012515489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HEQ5402887.1"
                     /translation="MKIIAKKDLFINDEIRVREVRLVGLEGEQLGIKPLSEAQSLADA
                     SNVDLVLIQPQAVPPVAKLMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPVIDKGD
                     FETKLRNGRKFLEKGNKVKVSIRFKGRMITHKEIGAKVLADFAEATQDIAIIEQRAKM
                     DGRQMFMQLAPISDNK"
     gene            4656..4853
                     /gene="rpmI"
                     /locus_tag="VHC05_001600"
     CDS             4656..4853
                     /gene="rpmI"
                     /locus_tag="VHC05_001600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002895038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HEQ5402888.1"
                     /translation="MPKQKTHRASAKRFKRTGSGGLKRFRAFTSHRFHGKTKKQRRHL
                     RKAGLVSSGDFKRIKAMVTGL"
     gene            4912..5271
                     /gene="rplT"
                     /locus_tag="VHC05_001601"
     CDS             4912..5271
                     /gene="rplT"
                     /locus_tag="VHC05_001601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019786714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HEQ5402889.1"
                     /translation="MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYY
                     YAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVAD
                     AAAFTALADAAKAKLGK"
     gene            complement(5562..7772)
                     /locus_tag="VHC05_001602"
     CDS             complement(5562..7772)
                     /locus_tag="VHC05_001602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LTA synthase family protein"
                     /protein_id="HEQ5402890.1"
                     /translation="MTSLGKNDKEVATVKKFKTLITGFINTRLGFIITLLFCYWIKTL
                     WAYHTDFSLDLGNIYQVFLTIINPIPLAFLLLGVALYVKNTRAFYICSWVVYIILNIL
                     LISNSIYYREFSDFITVSAMLASSKVSAGLGDSALNLLRIWDIIYILDFIILISLSIT
                     KKIKNDQRPFNKRAAFAITALSSLLLSINLFLAEIDRPELLTRGFSNTYIVRALGLPA
                     FTLYSGNQTYQAQKERNGATAEELIDVKTYVKGHYAAPDPQYFGIGKGKNIIVLHLES
                     FQQFLIDYKLKEGDKEYEVTPFINSLYHSNATLAFPNFFHQVKAGKTSDAETMMENSL
                     FGLNSGSFMVNYGGENTQFATPSILAQKGGYTSAVFHGNVGTFWNRNNAYKQWGYNYF
                     FDSSYFSKQNSKNSFQYGLNDKYMFKDSIKYLEQMQQPFYTKFITVSNHYPYTSLKGE
                     SSEEGFPLAKTDDETINGYFATANYLDAALKSFFDYLKATGLYDNSIFVLYGDHYGIS
                     NSRNSSLAPLLGKDSETWSEYDNAMLQRVPYMIHIPGYTNGSIKETFGGEIDALPTLL
                     HILGIDTSQFVQLGQDLLSPQNSQIVAQRTSGTYMTPEYTNYSGRLYNTQTGLEITNP
                     DEMTIAKTKEIRSAVAQQLAASDAIQTGDLLRFDTQNGLKAIDPNQFIYTKQLKQLKD
                     ISAKLGSESTSLYSKNGHKSTQKLFKAPSYLELNPVEADAATSELKEDNTKNRE"
BASE COUNT         2568 a         1279 c         1540 g         2483 t
ORIGIN      
        1 acatactttt tattagtatg ccttccatta tttattccta atgaaaaatt cggaaaaaat
       61 accaagttag tcatcttgaa aaaattggga ggactattac tcatttttct ttttgctgca
      121 atgtggttta gactttatgg acaggttaaa accccatatg tcgcggattt tctaaaagaa
      181 gtaaacgtta gccagcaagt taaaaatatg ctagaatccc ctatagtcta tagcagtatt
      241 attattagac atatggtaat taatctgatt aatatgaata atatttttca gtttggcgca
      301 ttaagctatg gtataacgaa ccttttcccg ctttatgtgt gtttcttctt ttttgtttat
      361 attagtaatg ctagtaaaat aactattaat attgtagaaa aaatgggtat aatctttgtt
      421 atttcagcga ttataggtgc aactgtatta gctatgtacc tgacttggac accagtaggg
      481 tcctcaactg tcttaggtgt tcaaagtcgt tatctgatag gaattatccc attagtgttg
      541 cttcttttta gtagtcaaca gcaaaagttc aaacaaatag aggatatcct ttctgacaaa
      601 ctggctattc atatttcgct tttgtttatt ctcgcaatgt taatgagtac tatttttaga
      661 tattatcatt aaactcttaa ttagaggctt taaaaaactt agcttgaata agtattttaa
      721 agccttttat gctataatta aattgagaaa ttattgaggt ggcctatgaa gtacgataac
      781 ttgttagatc gatttataaa atatgtcaaa gtgaatacaa gaagcgatcc agacagtgag
      841 actactccta gtacggagag tcaagaagca tttgccttaa cgattttaaa gcctgaaatg
      901 gaggcaattg gtttgcaaga tgttcattat aatccagtta atggctatct tattggaact
      961 ctgcctgcca ataatccaac cttgacgcgt aaaattggtt ttatagccca tatggatacg
     1021 gctgatttca atgctgaaaa tgttaatccg cagattattg acaattatca aggaggggac
     1081 attacacttg gcagttctaa ttataagttg gatccaaaag catttccgaa tcttaataat
     1141 tatatcggtc aaacattgat taccactgat gggactacac ttttaggggc agatgataaa
     1201 tctggtattg ctgaaatcat gacagcaata gaattcttaa catcacaacc acaaatagag
     1261 cactgtgaca ttaaagtggc ttttggccct gatgaagaga ttggggtcgg agctgataag
     1321 tttgaggtgg ctgattttga ggtggatttt gcttatacta tggatggcgg tcctttaggc
     1381 gaattgcaat atgaaacttt cagcgctgca gctctagaag tgactttttt aggcagaaat
     1441 gttcatcctg gtacggctaa ggatcaaatg attaatgccc ttcagttagc aatagatttt
     1501 catgagaagc tacctgctaa agagcggcct gaatacacag atggttatca aggcttctat
     1561 cacttaacgg gactaactgg aacagttgaa gaggcacggg catcttacat tattcgtgat
     1621 tttgaagaag catcatttga agctagaaaa gtgaaagttg aaaatatagc tcaatcgatg
     1681 aatgctcagc taggaacaaa acgtgtcttg gtagagctta atgaccaata ctacaatatg
     1741 aaaaaagtta tcgaaaaaga tatgaccgct attgagttag ctaaagaagt aatggaagag
     1801 cttactatca agcctgtaat cgaacccata cgtggaggaa cagatggctc taaaatttca
     1861 tttatgggta ttcccactcc taatattttt gcagggggtg agaatatgca cgggcgtttt
     1921 gagtttgtta gcttacaaac gatggagaga gctgtcgatg tcattattgg acttgtttgc
     1981 aaagcctaat tatcatgtaa ttgatattta gtggaagggg cttataaaaa tgattaaact
     2041 atttggtaaa ataaggtatc actggcagcc agagttgtct tggtctatta tttattggtc
     2101 tattgcgttt gcacctattt ttgtaggttt atctttgttg tatgagcgca ctgaaatacc
     2161 tagtcgggtt tttattctat ttgctatttt tgctgtccta gttggcattg gattacatcg
     2221 ttatttcatt attgaaaata atggtatttt aagaatcgta tcttttaaat tgtttggtcc
     2281 acgtaagcta cttatttcca ctattactaa gattgaggtg accaaatcaa cactttgtct
     2341 gcacgttgaa gataaaagtt atctctttta tatgcgcaaa tggcctaaaa aatattttct
     2401 tgatgcctta gcggttaatc catacttcca aggagaagtt atattaagtg ataactttat
     2461 taaattagac tattttgaag tttatcagca tgataaaaaa gcccttactc gagggtaaga
     2521 gctttagttg ggcaagattt gacagctaaa atagcgtcct tatctgaagg acaaattgac
     2581 tgacttgttt cagatgagct tgaaaatgtg acgataccat tgtcatgata atcaaaaagt
     2641 gatgaatagg tttggcatag accacaagcg atgcattttt ctggaatgat agatactttc
     2701 ataactatta ttctaatatg attttgttaa attaacaagg ggggacgatc atggctaaag
     2761 aaccatggga agaaaaaatt gttgatgata ctatagggac acgaacacgt aaatcaagaa
     2821 atgctttcat tagcacgcct tggttgactg ctttattaag tgtattcttt gtcatcattg
     2881 ttgctatact ttttattttc ttctatacat caaatagcgg tagtaataga caagctgaaa
     2941 caaatggttt ttatggagca tccactcata aaaaaacaag gaaagcttct aacgctaaaa
     3001 aaacatcaag tagttcaaca actacagaca caacaccttc tagcgaagaa atacttgctt
     3061 ctagtgaagg aaccggcgaa acccttactg tattggcagg tgagggggca gcttctattg
     3121 cagctcgtgc aggtatttct gtggagcagt tacaagcact taatccagag cacatgactc
     3181 aaggatattg gtatgccaat ccaggagatc aagtcactat taaataattg aagaggaaaa
     3241 aatgaaagca attaaaattg cgattgatgg gccagcttca agtggaaaaa gtacagtagc
     3301 caagattatt gcaaaaaatc ttggctatac ttatctagat actggtgcta tgtatcgctc
     3361 agcaacttat atcgcactga cacatggcta tacgggtaaa gaagtagccc ttattttaga
     3421 ggaacttgag aaaaatccta tttcctttaa aaaagcaaaa gatggctccc aattagtttt
     3481 tcttggggat gaggacgtga ccttagccat taggcaaaat gatgtgacta acaatgtttc
     3541 ttgggtctca gctttgccag aaattagaga agagctggtt catcaacaaa gacgcattgc
     3601 acaagctggt ggcattatca tggatggtcg tgacattgga acggttgttc tcccagatgc
     3661 ggaactaaaa atctttttag tggcttctgt cgaagagcgg gcagagcgcc gctataaaga
     3721 aaacctagaa aaaggaattg aatcagattt tgagacgcta aaagaagaga ttgcagctcg
     3781 tgattacaag gatagtcatc gtaaggtttc acctctaaaa tcagctgaag atgcccttat
     3841 ttttgatacc acaggtgttt ctattgatgg cgtggtgcaa tttatccaag aaaaagcaga
     3901 aaaaatagtt gacatgtcct agagcctatg ttagaatagt aacaatgaga aaagcagaag
     3961 tgagagcttc tcgccttgcg acttaggttg tctggcccta acatgtcaaa ttcctatgga
     4021 atattatatg tgcgggcttg atttatcaag tccgctttcg tttttctcta aaaaaataaa
     4081 gaggtgaaga tcatagctaa aaaggatcta ttcattaatg atgaaattcg cgttcgcgaa
     4141 gttcgtctcg ttggtcttga aggtgaacaa ttaggtatta aaccattgtc tgaagcgcaa
     4201 tcattggctg atgcttcaaa tgttgatttg gttttaatcc agccacaagc tgttcctcct
     4261 gttgccaaac ttatggacta tggaaagttc aaatttgagt atcaaaagaa acagaaagaa
     4321 caacgtaaaa aacaaagcgt tgtgactgtg aaagaagttc gtctcagtcc agttatcgat
     4381 aaaggtgact ttgaaacaaa acttcgtaac ggtcgtaaat tccttgaaaa aggaaataaa
     4441 gttaaggttt ctattcgttt caaaggacgt atgattactc ataaagagat tggtgccaag
     4501 gtactagctg actttgctga agcgactcaa gatattgcta tcattgagca acgagcaaaa
     4561 atggatggac gccaaatgtt tatgcaactt gcaccaattt cagacaataa gtaattgtca
     4621 cagtttcatt atatctttaa gaggagaata ctaaaatgcc aaaacaaaaa acacaccgcg
     4681 catcagctaa acgttttaaa cgtacaggtt caggcggttt gaaacgcttc cgcgccttta
     4741 catcacaccg tttccacgga aaaactaaaa aacaacgtcg tcatcttcgt aaagctggtt
     4801 tggttagctc aggagatttc aaacgtatca aagcaatggt tactggtctt taattttaaa
     4861 ggcagtagac atttacgagt attataagaa ttatttgaag gagaactatt aatggcacgt
     4921 gttaaaggtg gcgttgtttc acgcaaacgt cgtaaacgta ttttaaaatt agctaaaggt
     4981 tactatggag caaaacacat cttgttccgt actgcaaaag agcaagtgat gaactcttac
     5041 tactatgcat accgtgatcg ccgtcagaaa aaacgtgatt tccgtaaact atggatcact
     5101 cgtatcaatg cggctgctcg tatgaacggt ttgtcatact cacaattgat gcacggtttg
     5161 aaacttgctg aaatcgaagt aaaccgtaaa atgcttgctg atttagcagt agctgatgca
     5221 gcagctttca cagctcttgc tgatgcagcc aaagcaaaac ttggcaaata agaaacgcta
     5281 tacctaaaaa ataactttct attacctata gaaagttata aagaaacaaa aatgaaggag
     5341 acgatggacg tcttcttttt attatactca atataataaa aagaagtttc ccatgtttta
     5401 ttaccagtaa tgtgggatat ttagatggta gcaagaagtt ttatagttga tttgttttct
     5461 ttaggtctaa ttagcatatt ttgattactg ataaacttga atatcgccaa taaaaaagaa
     5521 gcaaaattat tattttgctt ctagtcagat cattaaattg attattctct atttttggtg
     5581 ttatcctctt ttagttcaga agttgccgcg tcagcttcta cgggatttag ttctaagtaa
     5641 gatggtgctt taaaaagttt ctgagttgat ttatgaccat ttttactgta taaacttgtt
     5701 gactctgatc cgagttttgc tgaaatatct ttcagttgtt ttaactgctt agtgtagata
     5761 aactggttag gatcaatagc ttttagacca ttttgagtat caaagcgcag gagatcaccc
     5821 gtttgaatag cgtcgctagc tgctagttgt tgagcaacag cagagcgaat ttccttagtt
     5881 ttggctatag tcatttcatc gggattagtg atttctaaac ctgtttgcgt gttgtacaga
     5941 cgtccactat agttagtgta ttcaggagtc atataagtcc cagatgttcg ttgtgccaca
     6001 atctggctat tttgaggtga taataaatct tgtcctaatt gaacaaactg actagtgtca
     6061 ataccaagta tgtggagtaa agtaggaaga gcatcgattt caccgccaaa ggtttctttg
     6121 atactaccat tcgtataacc tggaatatgg atcatatacg ggactcgttg tagcatagca
     6181 ttatcatatt cagaccaagt ttcagaatct ttaccaagaa gtggagcaag actagaatta
     6241 cgagaatttg aaataccata atggtcacca tataaaacaa aaatagaatt gtcgtacaaa
     6301 ccagtggctt tcaagtaatc aaaaaaagat ttaagggcag cgtctaaata attggcagta
     6361 gcaaagtaac cattgatcgt ttcatcgtct gttttggcta aaggaaaacc ttcttcacta
     6421 ctttcgcctt ttagactagt ataaggatag tgattactca cagtgataaa cttggtataa
     6481 aaaggttgtt gcatctgttc aagatatttt atggaatcct taaacatgta cttatcattt
     6541 aacccatatt gaaaagagtt cttactattt tgtttagaga agtagctaga atcaaaaaaa
     6601 taattatagc cccattgttt ataagcatta ttgcgattcc agaaagttcc aacgttacca
     6661 tgaaagacag cgctggtata gccacctttt tgggctaaaa tacttggagt agcaaattgt
     6721 gtattttcac caccgtagtt caccataaaa gaaccactat ttaaaccaaa taaggaattc
     6781 tccatcatgg tttcagcatc agaagtttta cctgctttaa cctgatgaaa aaagttaggg
     6841 aatgctaagg tagcatttga gtgataaagc gagttgataa aaggcgttac ctcatattct
     6901 ttatctcctt cttttagttt ataatctatt aagaattgtt gaaagctttc taaatgaaga
     6961 acaataatat ttttgccttt tccaattcca aaatactggg gatcaggtgc tgcataatgt
     7021 cctttgacat aagttttaac atcaattaat tcttctgcag tagctccatt tcgttctttt
     7081 tgagcttgat aggtttgatt gccgctatag agggtaaacg ctggtaatcc taaagctctc
     7141 acaatataag tatttgaaaa gccacgtgtt aatagttccg gacgatcaat ttctgctaaa
     7201 aaaagattaa tagaaagcaa tagactagat aaagcggtga tggcaaatgc tgcgcgcttg
     7261 ttaaaaggac gttgatcatt tttgattttt ttagtgatag ataaactaat tagaataata
     7321 aaatcaagaa tatagataat atcccagatg cgtaaaaggt ttaaagcaga gtcccctaat
     7381 ccagcggaga ctttactgct agctagcatg gcactcactg taataaagtc tgaaaattct
     7441 cggtaatata tagaatttga tatcaagaga atgttaagga taatataaac cacccaagaa
     7501 cagatataaa aggctcgggt attcttaacg taaagagcga cccccaaaag taaaaaagct
     7561 agtgggattg gattgataat tgttagaaag acttggtata tatttcccaa atctagtgaa
     7621 aagtctgtat gatatgccca cagagtcttt atccagtaac aaaagagtag agtaattata
     7681 aaacccaatc ttgtgttgat aaaacctgtg ataagtgttt taaatttctt cacagtagca
     7741 acttccttat cgttttttcc taaagatgtc atctccaaat aaaatctcag attaaattat
     7801 accaaaaatg tgaagctaat gcttgttgta agttcaaatt tagtaggatt ttttatcaga
     7861 ttttgttata
//
LOCUS       DAUDWO010000056         7010 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.057, whole genome shotgun sequence.
ACCESSION   DAUDWO010000056 DAUDWO010000000
VERSION     DAUDWO010000056.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7010)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7010)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7010
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.057"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(46..318)
                     /locus_tag="VHC05_001603"
     CDS             complement(46..318)
                     /locus_tag="VHC05_001603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Veg family protein"
                     /protein_id="HEQ5402891.1"
                     /translation="MSDAFTDVAKMKKIKEDIRAHEGQLVELTLENGRKREKNKIGRL
                     IEVYSSLFIIEYSDSSDTPGAIDNSYVESYTYSDILTEKTLIRYLD"
     gene            complement(335..1702)
                     /gene="dnaB"
                     /locus_tag="VHC05_001604"
     CDS             complement(335..1702)
                     /gene="dnaB"
                     /locus_tag="VHC05_001604"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replicative DNA helicase"
                     /protein_id="HEQ5402892.1"
                     /translation="MRLPEVAELRVQPQDLLAEQSVLGSIFISPDKLIAVREFISPDD
                     FYKYAHKIIFRAMITLSDRNDAIDATTIRTILDDQDDLQSIGGLSYIVELVNSVPTSA
                     NAEYYAKIVAEKAMLRDIIARLTESVNLAYDEILKPEEVIAGVERALIELNEHSNRSG
                     FRKISDVLKVNYEALEARSKQTSNVTGLPTGFRDLDKITTGLHPDQLVILAARPAVGK
                     TAFVLNIAQNVGTKQKKTVAIFSLEMGAESLVDRMLAAEGMVDSHSLRTGQLTDQDWN
                     NVTIAQGALAEAPIYIDDTPGIKITEIRARSRKLSQEVDGGLGLIVIDYLQLITGTKP
                     ENRQQEVSDISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDA
                     DIVAFLYRDDYYRKEGDDAEEAVEDNTIEVILEKNRAGARGTVKLMFQKEYNKFSSIA
                     QFEER"
     gene            complement(1732..2184)
                     /gene="rplI"
                     /locus_tag="VHC05_001605"
     CDS             complement(1732..2184)
                     /gene="rplI"
                     /locus_tag="VHC05_001605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="HEQ5402893.1"
                     /translation="MKVIFLADVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEATSQSI
                     GELKGKQKAEEKAQAEILAEAQAVKAVLDEDKTRVQFQEKVGPDGRTFGSITAKKISE
                     ELQKQFGVKVDKRHIVLDHPIRAIGLIEVPVKLHKEVTAEIKLAITEA"
     gene            complement(2181..4157)
                     /locus_tag="VHC05_001606"
     CDS             complement(2181..4157)
                     /locus_tag="VHC05_001606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003045829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HEQ5402894.1"
                     /translation="MKKFRFETIHLIMMGLILFGLLALCVSIMQSKILILLAIFLVLL
                     FVVALLWYQKEAYQLSDLAHIELLNEQTEDNLKTLLDNMPVGVVQFDQETNAVEWYNP
                     YAELIFTTEEGFIQNSLIQQIITEKRREDISQTFEVSGNKYTSYIDVSSGIFYFFDSF
                     VGNRHLADASMLRPVVGIISVDNYDDITDDLSDADTSKINSFVANFIDEFMESKRIFY
                     RRVNMDRYYFFTDFKTLNDLMDNKFSVLEEFRKEAQDAQRPLTLSIGISFGEENHSQI
                     GQVALENLNIALVRGGDQIVIRENADHTNPIYFGGGSVSTVKRSRTRTRAMMTAISGR
                     IKMVDNVFIVGHRKLDMDALGSAVGMQFFAGNIIENSFAVYNPDEMSPDIERAIERLQ
                     ADGKTRLISVSQAMGLVTPRSLLVMVDHSKISLTLSKEFYEQFQNVIVVDHHRRDDDF
                     PDNAILTFIESGASSAAELVTELIQFQNAKKRLNKIQASVLMAGIMLDTKNFSTRVTS
                     RTFDVASYLRSKGSDSVEIQNISATDFEEYKQINEIILQGERLGDSIIVAAGEKNHLY
                     SNVIASKAADTILSMAHVEASFVLVETASHKIAISARSRSKINVQRVMEKLGGGGHFN
                     LAACQLTDISLPQAKHLLLKTINMTMKETGEVES"
     gene            complement(4247..6145)
                     /gene="mnmG"
                     /locus_tag="VHC05_001607"
     CDS             complement(4247..6145)
                     /gene="mnmG"
                     /locus_tag="VHC05_001607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HEQ5402895.1"
                     /translation="MTHEFTENYDVIVIGAGHAGVEASLATSRMGCKTLLATINLDML
                     AFMPCNPSIGGSAKGIVVREIDALGGEMGKNIDKTYIQMKMLNTGKGPAVRALRAQAD
                     KSLYAREMKHTVEKQANLTLRQTMIDDILVEDGRVVGVLTATGQKFAAKAVVVTTGTA
                     LRGEIILGELKYSSGPNNSLASVTLADNLKKLGLEIGRFKTGTPPRVKASSINYDQTE
                     IQPGDDKPNHFSFMSKDADYLKDQIPCWLTYTNQTSHDIINQNLYRAPMFSGIVKGVG
                     PRYCPSIEDKIVRFADKERHQLFLEPEGRDTEEVYVQGLSTSLPEDVQKDLIHSIKGL
                     EKAEMMRTGYAIEYDIVLPHQLRATLETKLISGLFTAGQTNGTSGYEEAAGQGLIAGI
                     NAALKVQGKPELILKRSDAYIGVMIDDLVTKGTLEPYRLLTSRAEYRLILRHDNADMR
                     LTEIGRDIGLVDDERWKAFEIKKNQFDNELKRLNSIKLKPVKATNDRVQELGFKPLTD
                     AMTAKEFMRRPEIDYATAVSFVGPAAEDLDAKIIELLETEIKYEGYIRKALDQVAKMK
                     RMEEKRIPANIDWDAIDSIATEARQKFKKINPETIGQASRISGVNPADISILMIYLEG
                     NGKAHRKY"
     gene            complement(6269..6586)
                     /locus_tag="VHC05_001608"
     CDS             complement(6269..6586)
                     /locus_tag="VHC05_001608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011529140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX domain-containing protein"
                     /protein_id="HEQ5402896.1"
                     /translation="MIVRNGKNFLTRDAADQYYTIGGTSLVGEKTHETVLRETLEEVG
                     IRAKVNQLAFVVENHFDIDDVFWHNIEFHYLASPLEDPKLEMIENASDRFVNGFQSIN
                     WIK"
BASE COUNT         2131 a         1474 c         1095 g         2310 t
ORIGIN      
        1 attatatcaa tttattgtaa agaaaaagcc tctatgaggc aaaaatcaat ctaaataacg
       61 aattaatgtt ttttctgtca aaatatctga ataggtgtat gattcgacat aagaattatc
      121 aattgctcct ggagtatcag agctatcact atactcaatg ataaagagtg aactgtaaac
      181 ttcaataagc ctaccaattt tatttttttc ccgtttccgt ccattctcaa gggttaattc
      241 tactaactgt ccttcatggg ctcttatgtc ctctttaatt tttttcattt ttgcaacatc
      301 tgtaaatgca tcgctcattt tttgtctctc tttcttatct ttcttcaaac tgggctatac
      361 ttgagaattt gttgtattct ttttggaaca tcagtttgac tgttccacgc gccccagctc
      421 tatttttctc gaggataact tcaattgtgt tatcttcaac agcttcttca gcatcatcac
      481 cttctttacg gtaataatcg tcccggtata agaaggctac aatatcggca tcctgctcaa
      541 tagatcctga ttcacgaata tctgataaaa ctggtcgttt atcctgcctt tgctcaacgc
      601 cacgagaaag ctggcttagg gcaataactg gtactttcaa ttctttagct aggattttaa
      661 gctgtcttga aatatctgaa acctcttgct gacgattttc gggtttagtt cctgtaatca
      721 actgtaagta gtcaattaca atgagaccta aaccaccatc cacttcttga gacaatttcc
      781 gtgatcttgc gcggatttca gtaattttaa tcccgggcgt atcgtcaata taaatcggtg
      841 cttctgccaa agctccctga gcaattgtta cattattcca gtcctgatct gtgagttgcc
      901 ctgttcttaa actgtgcgaa tcaaccattc cttctgctgc aagcatgcga tctactaaac
      961 tttcagcacc catttccaaa gaaaaaatag caacagtctt tttttgctta gtccccacat
     1021 tttgcgcaat attaagaaca aaggcagtct tccccactgc tggccgagca gctaaaataa
     1081 ctaattgatc tgggtgtaaa cctgttgtaa tcttgtcaag gtctctaaaa ccagttggta
     1141 aacctgtaac atttgaagtc tgcttagaac gtgcttctaa agcctcgtaa ttaactttta
     1201 acacatctga aattttgcga aacccactac gattactatg ttcattgagt tcaattaaag
     1261 ctctctcaac tccagcgata acctcttctg gttttaaaat ttcatcataa gctaggttga
     1321 cagattctgt caacctagca ataatatcac gcaacatagc tttctcagct acaattttag
     1381 cataatattc tgcattagcg ctagttggga cactattaac tagttcaaca atataggata
     1441 agccaccaat actttgcaga tcatcttgat catctaggat tgttcttata gtggttgcat
     1501 caatggcatc attacgatcg ctgagagtaa tcattgcccg aaagataatt ttatgagcgt
     1561 acttataaaa atcgtctgga ctgataaatt ctctcactgc aatcagctta tcaggtgaga
     1621 taaagattga cccaagaaca gattgctctg ctagtaaatc ttggggttga actcgtaatt
     1681 cagctacttc aggcaacctc ataacctcca aatcttgtga tgttttttat attatgcttc
     1741 tgtgatagcc aatttaatct cagctgttac ttccttatgt aatttcacag gaacttcaat
     1801 tagaccaatg gcgcggatag gatgatctaa aacaatatga cgtttatcaa cttttacacc
     1861 aaattgcttt tgcaattctt ctgaaatctt tttagctgtg atggaaccaa atgtacgtcc
     1921 atctggacca actttttctt gaaattgaac acgtgttttg tcctcatcca aaacagcctt
     1981 gacagcttga gcttctgcta atatttcagc ttgagctttt tcttcagctt tttgttttcc
     2041 ttttaattca ccgatgcttt gactagttgc ttctttagct aaatttttct taataaggaa
     2101 attttgagca tagcctgttg ggacctcttt gatttctcct tttttacctt ttccttttac
     2161 atctgctaaa aaaataactt tcatgattct acttctcctg tttctttcat tgtcatatta
     2221 atagttttca ataataagtg cttcgcttgg ggaagactga tatccgttaa ctgacaggca
     2281 gcaagattaa agtggcctcc tccacctaat ttttccatca cacgttgaac attgatttta
     2341 ctacgacttc tagctgaaat agcaatctta tgagaagctg tttcaactaa tacaaagcta
     2401 gcctcaacgt gagccattga cagtatcgta tctgcagctt tactagcaat aacattgcta
     2461 taaagatgat ttttttctcc tgcagctaca atgatactgt caccaagacg ttctccttgt
     2521 aaaataattt catttatttg cttatattct tcaaaatctg ttgcggatat attttgaatt
     2581 tcaacactat cacttccttt gcttcttagg taactagcga catcaaaggt acgacttgtc
     2641 actcgcgtag aaaaattttt agtatcaagc ataatacctg ccattaaaac actggcttgg
     2701 atcttattta aacgtttttt agcattttga aattgaatta actcagtgac gagctccgca
     2761 gcactacttg ctccactttc aataaaagtt aagatagcat tatcaggaaa atcatcatct
     2821 cttctgtgat gatcaactac aataacattt tgaaactgtt cataaaattc tttagaaagt
     2881 gttaaagata tcttagaatg atcaaccatt actaaaagtg atcttggagt cactaaaccc
     2941 attgcttgag aaacactgat tagacgagtc tttccgtcag cctgcaatcg ctcaatagcc
     3001 ctttcaatat ctggactcat ctcatctggg ttgtaaacgg caaaactatt ttcaataatg
     3061 ttacctgcga aaaattgcat accaacagct gaacctagtg catccatatc aagtttccta
     3121 tgtccgacaa taaaaacatt gtccaccatc ttgattcgac ctgaaatagc tgtcatcata
     3181 gcacgggtac gtgttcttga acgtttaact gtagaaacag accctccccc gaaataaatt
     3241 ggattcgtat gatccgcatt ttcacgaatg acaatctgat caccaccacg aacaagcgca
     3301 atattaagat tctcaagagc tacctgtcca atctggctat gattttcttc accaaaagaa
     3361 attcctatgc tgagtgttaa agggcgctga gcatcttgag cttctttacg aaactcttct
     3421 aagacagaaa atttattatc catcaaatca tttaatgttt taaagtctgt aaagaaatag
     3481 tagcgatcca tattaacacg acggtaaaaa atccgttttg actccataaa ctcatcaatg
     3541 aagttagcta caaatgaatt aatttttgag gtatctgcat ctgataaatc atcagtgata
     3601 tcatcataat tatcaaccga aataatgcca acaaccggtc ttaacatact agcatcagct
     3661 aagtgcctgt ttcccacaaa gctatcaaaa aaataaaaaa ttcctgatga gacatcaata
     3721 taagaagtgt atttattacc agaaacttca aatgtttgag aaatatcttc acgacgtttt
     3781 tccgtaataa tttgctgaat caaactgttt tgtataaaac cctcttcagt tgtaaaaatt
     3841 aattctgcat aaggattata ccattctaca gcgttggtct cttgatcaaa ttgaactact
     3901 ccaacaggca tattatcaag tagcgttttt agattatctt ctgtttgttc atttaagagc
     3961 tcaatatgag ctaagtctga taattgataa gcttcttttt gataccataa aagagcaaca
     4021 acaaatagca aaacgagaaa aatagctaat aatattaata tttttgattg cataatactg
     4081 acacaaagtg ccagtagtcc aaataaaatc aatcccatca taatcaaatg aatggtttca
     4141 aaacgaaatt ttttcatctt ataacctctt aagcacacat tataccataa aaaagccctg
     4201 aaatacagag cttccacttg ctttgagatt acaatttcat ttccatttaa tattttcgat
     4261 gagcttttcc gtttccttct aaataaatca tcaagatact gatgtccgca ggattgactc
     4321 ctgaaatacg actagcttgt ccaattgttt caggattaat tttcttaaat ttctgacgcg
     4381 cctcagttgc aatagaatca atagcatccc aatcaatatt tgcaggaata cgtttttctt
     4441 ccatgcgttt catcttagca acctgatcta aagctttgcg aatatagcct tcgtacttga
     4501 tttctgtttc taaaagttca atgattttag catctaaatc ttcagccgca ggaccaacaa
     4561 aagagactgc agtcgcataa tcaatttctg ggcgacgcat aaattcttta gctgtcatag
     4621 catccgtcaa tggtttaaaa ccaagttcct gcacacgatc gttggttgct tttactggtt
     4681 ttaatttgat actgttcaga cgttttaatt cgttatcaaa ttggtttttc ttaatttcga
     4741 aggccttcca acgctcatca tcaaccaacc caatgtcgcg accaatctct gtcaaacgca
     4801 tatcagcgtt gtcatgacgt aaaatcaaac gatactcagc tcgcgatgtc aacaatcgat
     4861 aaggttccaa ggttcctttg gtaaccaaat cgtcaatcat aacgccaata taagcatcgc
     4921 tccgtttcaa aataagttct ggcttacctt gaactttcaa agcagcattg attccagcaa
     4981 taagtccttg gccagcagcc tcttcatacc cagaagttcc attagtttgc ccagccgtaa
     5041 agagtcctga aattagcttg gtttcaagtg tggcacgtag ctggtgaggt aaaacaatat
     5101 catattcaat agcataacca gtgcgcatca tttcagcctt ttcaagtcct ttgatcgaat
     5161 gaatcaaatc tttttggaca tcttctggaa gactcgttga caacccttga acataaactt
     5221 cttctgtatc acgcccctct ggctctaaga aaagttgatg acgttcttta tcagcaaagc
     5281 gaacaatctt atcttcaata gatgggcagt aacgagggcc tacaccttta acaatgccgg
     5341 aaaacatcgg tgctctgtaa aggttctgat taatgatatc atgactagtt tgattcgtat
     5401 aagtcaacca gcagggaatt tgatctttga gataatcagc atcttttgac ataaatgaaa
     5461 aatgattagg tttgtcatca cctggctgaa tttccgtttg atcgtaatta atagaagatg
     5521 ctttgacacg aggaggcgtt cctgttttga atctgccaat ttctaagccg agttttttta
     5581 aattatctgc taaggttact gatgccaaac tattattagg cccagaagaa tatttgagtt
     5641 ctcctaaaat aatttcgcca cgcagagctg ttcctgttgt cactacaact gccttagctg
     5701 caaatttttg tcctgtggct gttaaaacac ctacaactcg tccatcttca actagaatat
     5761 catcaatcat cgtttggcga agagtcaaat tagcctgttt ttcaaccgta tgtttcattt
     5821 cacgcgcata cagagattta tctgcttgag ctcggagagc gcgtacagct ggtcccttac
     5881 ctgtattaag cattttcatc tggatatagg ttttatcaat atttttaccc atttcgccgc
     5941 caagagcatc gatttctcgt actactatcc ctttggcaga tcctccaata gaaggattac
     6001 acggcataaa agcaagcata tcaaggttga ttgttgccaa taaagtttta caacccatac
     6061 gactagtggc caaactggct tcaacaccag catgacctgc acctatgaca atgacgtcat
     6121 agttttctgt aaattcatgt gtcatttttt taaaatcctt tatttcagtc tattcattta
     6181 aaatcatacg ctttagttta gccttcaatg cggacaatat gtcctggcca tttagccaac
     6241 tcggtttgta aaaactcagg aacaagattc atttgatcca gttgattgat tggaatccat
     6301 tcacaaacct gtcgcttgca ttctctatca tttctagttt agggtcttct aaggggcttg
     6361 ccaaataatg aaattcaata ttatgccaga aaacatcatc gatatcaaaa tgattctcaa
     6421 ccacaaaagc cagttgatta accttagctc gaataccaac ttcctctaag gtttcacgta
     6481 aaacagtttc atgcgttttt tcacctacca aacttgtacc accaatggtg taatattggt
     6541 cagctgcatc tctagttaaa aaattcttac catttctaac aatcaagcac tagctcgtaa
     6601 actaaagtta tctgacctct agtgattcta aatcccagtc ctattagcca tctcatttct
     6661 agagctaaac cataaaaagg gccaaaaccc tagaagattg caggacaaaa aaacctacaa
     6721 ctttcatgag ctttgaccat cattccgatt gttactattt taaaaaaatg attagtgatt
     6781 gtcaacattg atttcatcac agacctttac agtaatgcca atgtttttac agctctgtca
     6841 atctattgta atgtttttaa aatgattgca aaagtatcac tatgtctaat ctagcgaggc
     6901 gagaaataaa aatgtcatca gtattatcat acgatttttt gatatcttct taaagtagta
     6961 aaatacagat accattgttt ctaagtctac aagtaagaac gccgataaca
//
LOCUS       DAUDWO010000057         6684 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.058, whole genome shotgun sequence.
ACCESSION   DAUDWO010000057 DAUDWO010000000
VERSION     DAUDWO010000057.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6684)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6684)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6684
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.058"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..831
                     /gene="dnaN"
                     /locus_tag="VHC05_001609"
     CDS             <1..831
                     /gene="dnaN"
                     /locus_tag="VHC05_001609"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HEQ5402897.1"
                     /translation="QVVLTSGKSEITLKGKDVDQYPRLQEVSTENPLILKTKLLKSII
                     AETAFAASLQESRPILTGVHIVLSNHKDFKAVATDSHRMSQRLITLDNTSADFDVVIP
                     SKSLREFSAVFTDDIETVEVFFSPSQILFRSEHISFYTRLLEGNYPDTDRLLMTEFET
                     EVVFNTQSLRHAMERAFLISNATQNGTVKLEITQNHISAHVNSPEVGKVNEDLDIVSQ
                     SGSDLTISFNPTYLIESLKAIKSETVKIHFLSPVRPFTLTPGDEEESFIQLITPVRTN
                     "
     gene            906..1103
                     /locus_tag="VHC05_001610"
     CDS             906..1103
                     /locus_tag="VHC05_001610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF951 family protein"
                     /protein_id="HEQ5402898.1"
                     /translation="MYQIGSFVEMKKPHACVIKETGKKANQWKVLRVGADIKIQCTNC
                     QHVIMMSRYDFERKLKKVLQP"
     gene            1433..2548
                     /gene="ychF"
                     /locus_tag="VHC05_001611"
     CDS             1433..2548
                     /gene="ychF"
                     /locus_tag="VHC05_001611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-regulated ATPase YchF"
                     /protein_id="HEQ5402899.1"
                     /translation="MALTAGIVGLPNVGKSTLFNAITKAGAEAANYPFATIDPNVGMV
                     EVPDERLQKLTELITPKKTVPTTFEFTDIAGIVKGASRGEGLGNKFLANIREVDAIVH
                     VVRAFDDENVMREQGREDAFVDPIADIDTINLELILADLESINKRYARVEKMARTQKD
                     KESVAEFNVLQKIKPVLEDGKSARTIEFTEEEAKVVKGLFLLTTKPVLYVANVDEDKV
                     ANPDGIDYVKQIRDFAATENAEVVVISARAEEEISELDDEDKEEFLEAIGLTESGVDK
                     LTRAAYHLLGLGTYFTAGEKEVRAWTFKRGIKAPQAAGIIHSDFERGFIRAVTMSYDD
                     LMIYGSEKAVKEAGRLREEGKEYVVQDGDIMEFRFNV"
     gene            2618..3187
                     /locus_tag="VHC05_001612"
     CDS             2618..3187
                     /locus_tag="VHC05_001612"
                     /EC_number="3.1.1.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012657576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="HEQ5402900.1"
                     /translation="MVKMIVGLGNPGSKYEKTKHNIGFMAIDNIVKNLDVTFTDDKNF
                     KAQIGSTFINHEKVYFVKPTTFMNNSGIAVKALLTYYNIDITDLIVIYDDLDMEVSKL
                     RLRSKGSAGGHNGIKSIIAHIGTQEFNRIKVGIGRPLKGMTVISHVMGQFNTEDNIAI
                     SLTLDRVVNAVKFYLQENDFEKTMQKFNG"
     gene            3190..>6684
                     /gene="mfd"
                     /locus_tag="VHC05_001613"
     CDS             3190..>6684
                     /gene="mfd"
                     /locus_tag="VHC05_001613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription-repair coupling factor"
                     /protein_id="HEQ5402901.1"
                     /translation="MDILELFSQNKKVQSWHSGLTTLGRQLVMGLSGSSKALAIASAY
                     LDDQKKIVVVTSTQNEVEKLASDLSSLLDEELVFQFFADDVAAAEFIFASMDKALSRI
                     ETLQFLRNPKSQGVLIVSLSGLRTLLPNPDVFTKSQIQLTVGEDYDSDTLTKQLMTIG
                     YQKVSQVISPGEFSRRGDILDIYEITQELPYRLEFFGDDIDSIRQFHPETQKSFEQLE
                     GIFINPASDLIFEASDFQRGIEQLEKALQTAQDDKKSYLEDVLAVSKNGFKHKDIRKF
                     QSLFYEKEWSLLDYIPKGTPIFFDDFQKLVDKNARFDLEIANLLTEDLQQGKALSNLN
                     YFADNYRELRHYKPATFFSNFHKGLGNIKFDQMHQLTQYAMQEFFNQFPLLIDEIKRY
                     QKNQTTVIVQVESQYAYERLEKSFQDYQFRLPLVSANQIVSRESQIVIGAISSGFYFA
                     DEKLALITEHEIYHKKIKRRARRSNISNAERLKDYNELAVGDYVVHNVHGIGRFLGIE
                     TIQIQGIHRDYVTIQYQNSDRISLPIDQIGSLSKYVSADGKEPKINKLNDGRFQKTKQ
                     KVARQVEDIADDLLKLYAERSQQKGFSFSPDDDLQRAFDDDFAFVETEDQLRSIKEIK
                     ADMESMQPMDRLLVGDVGFGKTEVAMRAAFKAVNDHKQVAVLVPTTVLAQQHYENFKA
                     RFENYPVEVDVLSRFRSKKEQAETLERVRKGQIDIIIGTHRLLSKDVVFSDLGLIVID
                     EEQRFGVKHKETLKELKTKVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPTNRYPVQ
                     TYVLENNPGLVREAIIREMDRGGQIFYVYNKVDTIEKKVAELQELVPEASIGFVHGQM
                     SEIQLENTLIDFINGDYDVLVATTIIETGVDISNVNTLFIENADHMGLSTLYQLRGRV
                     GRSNRIAYAYLMYRPDKILTEVSEKRLEAIKGFTELGSGFKIAMRDLSIRGAGNILGA
                     SQSGFIDSVGFEMYSQLLEQAIASKQGKTTIRQKGNTEINLQIDAYLPDDYIADERQK
                     IDIYKRIREIQSREDYLNLQDELIDRFGEYPDQVAYLLEMALLKHYMDNAFAELVERK
                     NNQVIVRFEVTSLTYFLTQDYFEALSKTHLKAKISEHQGKIDIVFDVRHQKDYKILEE
                     LMLFGERLSEIKIRKNNSV"
BASE COUNT         2266 a         1021 c         1305 g         2092 t
ORIGIN      
        1 caagttgttt taaccagtgg taaatcagag attaccttaa aaggaaaaga tgttgaccag
       61 tatcctcgtc tacaagaagt atcaacagaa aatcctttga ttttaaaaac aaaattattg
      121 aagtctatta ttgctgaaac agcttttgca gccagtttac aagaaagtcg tcctatttta
      181 acaggagttc atattgtatt aagtaatcat aaagatttta aagcagtagc gactgactct
      241 catcgtatga gccaacgttt aatcactttg gacaatactt cagcagattt tgatgtggtt
      301 attccaagta aatctttgag agaattttca gcagtattta cagatgatat tgagaccgtt
      361 gaggtatttt tctcaccaag ccaaatcttg ttcagaagtg aacatatttc tttctataca
      421 cgtctcttag aaggaaatta tcccgataca gaccgtttat taatgacaga atttgagacg
      481 gaggttgttt tcaataccca atcccttcgc cacgctatgg aacgtgcctt cttgatttct
      541 aatgctactc aaaatggtac tgttaagctt gagattactc aaaatcatat ttcagctcat
      601 gttaactcac ctgaggttgg taaggtaaac gaggatttag atattgttag tcagtctggt
      661 agtgatttaa ctatcagctt caatccaact taccttattg agtctttaaa agctattaaa
      721 agtgaaacag taaaaattca tttcttatca ccagttcgac cattcaccct aacaccaggt
      781 gatgaggaag aaagttttat ccaattaatt acaccagtac gaacaaacta agtaagaaaa
      841 agctcccttt taggagtttt tttgttatta taaatattaa cgataatata agtggagaaa
      901 agggaatgta tcaaattgga tcatttgttg aaatgaaaaa acctcatgct tgtgtaatta
      961 aagaaactgg taaaaaggct aatcaatgga aggtactgag agtaggagct gatattaaaa
     1021 ttcagtgtac taactgtcag catgtgatta tgatgagtcg ttatgatttt gagcgaaaat
     1081 taaaaaaagt actgcaacca tgaaagtcct tttaaataaa taattctagc tatatttgca
     1141 accaatactt tcctaaaaaa ttgttagtat gccgttggaa aattagctat tctaatgtta
     1201 tcgaaagaag aaaggtggct attgacaatg acgaaagttg tagcacagtt acttagtttc
     1261 tcggcaaact atatcaaaat gagaataata caccaaactt tgataattta aatgaaggtg
     1321 aaagagtggc ataatgataa gcaaatctga aattttcttc ttattcatac cgctttttct
     1381 tctatttttt ggtataataa tcttgattga aatttgaatg gagattcgct aaatggcttt
     1441 aacagcaggt attgtaggct taccaaatgt tggtaaatca accttattta acgcaattac
     1501 aaaagcagga gcagaagctg ctaattatcc ttttgcgact attgatccca atgttggtat
     1561 ggtagaggtt ccagatgagc gtctgcaaaa attgacagaa ttgattacac ctaaaaaaac
     1621 agttccgaca acctttgaat ttactgatat tgcaggtatc gttaaaggtg cttctagagg
     1681 ggaaggtcta ggaaataaat ttttagctaa tattcgtgaa gtcgatgcta ttgttcatgt
     1741 ggtacgtgct tttgatgatg aaaatgtcat gcgtgaacaa ggtcgtgagg atgctttcgt
     1801 tgatcctata gcagatattg acactattaa tcttgaatta atcttagctg atttagagtc
     1861 aatcaataaa cgttatgcgc gtgttgaaaa aatggcacga actcaaaaag ataaagaatc
     1921 agtagcagag ttcaatgttt tacaaaagat taaacctgtt ttggaagatg ggaaatcagc
     1981 taggacaatt gagtttacag aagaggaagc aaaagttgtt aaaggtctct ttttattaac
     2041 aactaaacct gttttatatg tagctaatgt cgatgaagat aaagttgcta atccagatgg
     2101 tattgattat gtcaaacaaa ttcgtgactt tgcagctact gaaaatgctg aagtagttgt
     2161 tatctcagcg cgtgcagaag aagaaatttc agagcttgac gatgaggata aagaagaatt
     2221 tttggaagct atcggtctta ctgaatcagg cgttgataaa ttaaccagag cagcttatca
     2281 tctcttaggc cttggaacct attttacagc aggtgaaaaa gaggttcgtg cttggacgtt
     2341 taagcgtggt ataaaagctc cacaagctgc tggtattatc cattcagatt ttgaaagagg
     2401 ttttattcgt gcagtaacca tgtcttatga tgatctaatg atctacggtt cagaaaaagc
     2461 cgtcaaagaa gctggacgct tgcgtgaaga aggaaaagaa tacgttgttc aagatgggga
     2521 catcatggaa ttcagattta atgtgtaatt atattaaaac aatatcagaa ggttggaaga
     2581 acattccagc ccttttggca ttttagaaag agaaaatatg gtaaaaatga ttgttggtct
     2641 gggaaatcca ggctctaaat atgaaaaaac aaagcacaat attggtttta tggctattga
     2701 caatattgtc aagaaccttg acgttacctt tacagatgat aaaaatttta aagcacagat
     2761 aggaagtact tttattaatc atgaaaaagt ttactttgtg aaacctacta cttttatgaa
     2821 taatagcggc atagcagtaa aagcattact aacctactat aatattgaca taacagattt
     2881 aattgttatc tatgatgatt tagacatgga agtcagtaaa ttacgtttac gtagtaaggg
     2941 ttcggcagga ggacataatg gcattaagtc aatcattgcc cacattggaa ctcaggaatt
     3001 taaccgaatc aaagttggta ttggacgacc tttaaaaggt atgactgtta ttagccatgt
     3061 gatgggccaa ttcaataccg aagataatat tgctatttcg ttaactcttg acagagttgt
     3121 caatgctgtc aagttttatt tacaagaaaa tgattttgaa aaaacaatgc agaaatttaa
     3181 tggataatca tggatatttt agaattattt agtcagaata agaaagtcca atcctggcac
     3241 tctggattaa ccaccttagg aagacaactg gtaatggggt tatcgggttc aagtaaagca
     3301 ttggctatag cttccgctta tttagatgat caaaaaaaaa tagttgtggt tacatcaact
     3361 caaaatgagg ttgaaaaatt agccagcgat ttatctagtt tacttgatga agaacttgtt
     3421 ttccaatttt ttgcagacga tgtggctgca gcggaattta tctttgcgtc aatggataaa
     3481 gctctatcaa gaatagaaac cctgcaattt ttaaggaatc ctaaatctca gggcgtttta
     3541 attgttagtt tatcaggctt aagaacttta ttgccaaacc cagatgtttt tacaaagagt
     3601 cagattcaac taacagttgg agaagattat gatagtgata ctcttactaa acaactgatg
     3661 acaattggct atcagaaggt ctcacaggtt attagtccgg gagaatttag ccgtcgaggg
     3721 gatattttag atatctatga gattacacaa gaattgcctt atcgattgga attttttggc
     3781 gatgatattg atagtattag gcaatttcat ccagaaactc aaaaatcttt tgaacaacta
     3841 gaaggtattt ttattaatcc agcaagtgat cttatttttg aggctagtga ttttcaacgt
     3901 ggcattgagc aattagaaaa ggctctacaa acagcacaag atgataaaaa atcttattta
     3961 gaagatgtat tagctgtttc aaaaaacggt tttaaacata aggatatccg taaatttcaa
     4021 tcattatttt atgaaaaaga gtggtcatta ttagattata ttcctaaggg aacgccaatc
     4081 ttttttgatg attttcaaaa actagttgat aaaaatgcaa gatttgattt agagattgct
     4141 aatctcttga cagaagattt acagcaagga aaggctcttt ccaatcttaa ctactttgca
     4201 gataattatc gagagcttag gcactataag ccagcgacct tcttttcaaa ttttcataag
     4261 ggacttggaa atatcaaatt tgatcagatg catcagctaa ctcagtatgc catgcaggaa
     4321 ttttttaatc aatttccttt gttgattgat gagattaaac ggtatcaaaa aaatcaaaca
     4381 acggttattg tacaggtaga gtctcagtat gcttacgaac gacttgaaaa atcttttcaa
     4441 gattaccaat ttcgccttcc tttagtgagt gctaatcaaa ttgtttcacg tgaatcacaa
     4501 attgtaattg gagctatctc cagtggtttt tattttgctg atgaaaagtt agcgttgatc
     4561 acagagcatg aaatttatca taaaaagatc aaacgacgcg ctagacgatc taatattagc
     4621 aatgctgagc gtttgaaaga ttacaatgag ttagcagtag gtgattacgt ggttcataat
     4681 gtccatggta tcggtcgctt tcttggaatt gaaacgattc agattcaggg aatccatcga
     4741 gattacgtta ctattcaata tcaaaattca gaccgtattt ctcttccaat tgaccaaatt
     4801 ggtagcttat caaagtacgt ttctgctgat ggaaaagaac ctaaaattaa taaactcaat
     4861 gatggtcgtt ttcaaaagac aaagcaaaag gtcgctagac aagtagagga tattgctgat
     4921 gaccttctaa aattatatgc tgaaagaagt cagcaaaaag gattttcatt ttcaccagat
     4981 gatgacttgc agcgcgcttt tgatgatgat tttgcttttg tagaaacaga agatcaactt
     5041 aggtctataa aggaaattaa agctgatatg gagagcatgc aacctatgga tcgtctttta
     5101 gtaggcgatg taggatttgg taagacagaa gtagctatga gggcagcctt taaagcggtg
     5161 aatgatcaca aacaagtagc tgtcttagtt ccaaccacag tcttggccca gcagcattat
     5221 gaaaacttca aagcacgctt tgaaaattac cctgttgagg ttgacgtctt aagtcgtttc
     5281 cgtagtaaaa aagagcaagc tgaaacacta gaacgtgtac gaaaaggtca aattgacatt
     5341 attatcggaa cccatcgact cctatcaaaa gatgtggtct tttctgattt aggattaatt
     5401 gtgattgatg aggaacaacg gtttggtgtt aagcataaag aaactttaaa ggaattaaaa
     5461 actaaggttg acgtcttaac cttaacagct actccgattc ctagaacctt acacatgtct
     5521 atgttaggta tccgagattt atcggttatt gagaccccac caaccaatcg ttatcctgtt
     5581 caaacctatg ttttggaaaa taatccaggt ctcgttagag aagctatcat tcgtgaaatg
     5641 gatcgtggag gacaaatttt ttacgtttac aataaagttg acactattga aaagaaagtt
     5701 gcagagctac aagaattagt cccagaagct tctatcggtt ttgttcatgg gcaaatgagt
     5761 gaaattcaac ttgaaaatac cttgattgac tttataaatg gtgattatga tgtccttgtg
     5821 gctacaacaa tcatcgaaac aggagttgac atttctaatg taaatacttt gtttattgag
     5881 aatgctgatc atatgggatt gtcaacttta tatcaactga gggggcgcgt cggaagaagt
     5941 aatcgtattg cctatgctta cctgatgtat cgtcctgata agatcctaac agaagtctct
     6001 gaaaaacgtt tagaggctat taaaggcttt actgaattag gttcaggctt caagattgct
     6061 atgcgagatt tgtctatacg aggagcaggt aatattttag gagcttctca aagtggcttt
     6121 attgattcgg tcggttttga aatgtattct caattattag aacaggctat tgctagcaag
     6181 caaggaaaaa cgactattcg ccaaaaaggt aatactgaaa tcaatcttca gattgatgct
     6241 tatttaccag atgattatat tgcagatgag cgccaaaaaa ttgacattta caagcgtatt
     6301 cgagaaattc aatcaagaga agattatctc aatttgcaag atgagctgat agatcgtttt
     6361 ggagagtatc ctgatcaagt tgcctatttg ttagagatgg ctctgctaaa acattatatg
     6421 gacaatgcct ttgcggaatt agttgaacgc aaaaataatc aggtcattgt tcgatttgaa
     6481 gtaacttctt taacttattt cttaactcag gattatttcg aagccttatc gaaaacccat
     6541 cttaaagcta aaattagtga acatcagggg aaaatcgata tcgtctttga cgttcgccat
     6601 caaaaagatt ataaaatttt agaagaattg atgttatttg gagaaaggct tagtgagata
     6661 aaaataagaa aaaacaattc agtt
//
LOCUS       DAUDWO010000058         6480 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.059, whole genome shotgun sequence.
ACCESSION   DAUDWO010000058 DAUDWO010000000
VERSION     DAUDWO010000058.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6480)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6480)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6480
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.059"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(240..548)
                     /locus_tag="VHC05_001614"
     CDS             complement(240..548)
                     /locus_tag="VHC05_001614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402902.1"
                     /translation="MTRLISQQILSEYVKSLEVEADKVVIPGQNTPVFSWDRDGNLSI
                     DTPLLKVRGESLATQADLTTISLTPGPKGELWQTSVERLDIKVDKHISLTFKNGVRID
                     "
     gene            complement(613..1063)
                     /locus_tag="VHC05_001615"
                     /pseudo
     CDS             complement(613..1063)
                     /locus_tag="VHC05_001615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407405.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
     gene            complement(1168..1388)
                     /locus_tag="VHC05_001616"
                     /pseudo
     CDS             complement(1168..1388)
                     /locus_tag="VHC05_001616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424370.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(1407..1712)
                     /locus_tag="VHC05_001617"
     CDS             complement(1407..1712)
                     /locus_tag="VHC05_001617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="HEQ5402903.1"
                     /translation="MKEYQVTMSDDAKADLLSIYHYVRDELCAPQAADNLLERLSQGM
                     LSLSIFPERCAIIEDLIGKGYTFRQLIVKKYRIVYHVLEDEVIIVAVVYGSRHMNNW"
     gene            complement(1712..2014)
                     /locus_tag="VHC05_001618"
     CDS             complement(1712..2014)
                     /locus_tag="VHC05_001618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB/DinJ family
                     antitoxin"
                     /protein_id="HEQ5402904.1"
                     /translation="MAKTGTLNLRVDDSVKSAADDILKRLGIPMSTAIDMFLNQIILT
                     GGIPFDVSLPEAPQRVNVDYMSQEKFYDKLITSFEDAKTGNRQDVREFLFQLKENA"
     gene            complement(2069..2356)
                     /locus_tag="VHC05_001619"
     CDS             complement(2069..2356)
                     /locus_tag="VHC05_001619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402905.1"
                     /translation="MVPFGQGYKDMSPPSKELYKLMMVGKIQHVGHPVLKWMGQNVVM
                     RQAPAGNIKPDKEKSVEKIDGIVGLILGLDRCIRRQGDEASVYDERGILSF"
     gene            2261..3154
                     /locus_tag="VHC05_001620"
     CDS             2261..3154
                     /locus_tag="VHC05_001620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402906.1"
                     /translation="MTNMLDFPYHHEFIEFLGRWTHILITLPKRHHGQVDTAIPRYLL
                     VTIREKTGIVKLTTVQNTAFTTQSNQLKKQYGQFLLTESNNCCVCPGCDRPLILTSGN
                     LAAENYEVSAIEKDKDAEALNLIVLCPDCFLTYQADSRKKIVTALKNVKKILVSAHNS
                     QQAISDMKLDSGIVSVLTSLNKLKCDEYDISYDSKQLTDKISPENNRTLYQLVKNPVI
                     DNYLTIQKIIVNLDKQGKIDYEEIQYQTRSMYKKLKAAKHNNLAIFNTISEKLHMATL
                     QDIYFCQMIVSYFIQKCEVLE"
     gene            3154..3378
                     /locus_tag="VHC05_001621"
     CDS             3154..3378
                     /locus_tag="VHC05_001621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001176804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402907.1"
                     /translation="MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHAISEELD
                     DPTDFLSIMDCLYALNAIEMSNEGEVKLCL"
     gene            3369..4097
                     /locus_tag="VHC05_001622"
     CDS             3369..4097
                     /locus_tag="VHC05_001622"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="ATPase"
                     /protein_id="HEQ5402908.1"
                     /translation="MLIEMWSPVFKKHGEIREPICFHHGLNVIMGMDLADNSIGKSSS
                     LLAIDFIFGGNSYLKSIAVKKLGDHPIYFCFQFEKKFYFSRDTANPDIILVCDKSYSP
                     TGETMDLGIFLNRLKKRYHLDSPELSFRLAMSGFFRIAGKSNQNTDFPLQVYSSQKSS
                     ESITTLIQLFNLYDNIARYKERLKDKSDQLTTFRNARKYIFISNLVGGKKQFEANVSE
                     IKRLEYDLAHLQDTQQDKIDSDDI"
     gene            4182..5027
                     /locus_tag="VHC05_001623"
     CDS             4182..5027
                     /locus_tag="VHC05_001623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2326 domain-containing protein"
                     /protein_id="HEQ5402909.1"
                     /translation="MDISIEFGLYPTESDLTELQQYFPDTNLKKLYEVEAYHKKLETI
                     LDSEFSTERESLIAEIDELESQLTTLNQELQELGNIPNLSSEYLESYSKLTATINALK
                     EQNEAYLKESGLPKEKSGADADLKRSTEDILLDLEVKINSKMREFNNILYPDIRKAPQ
                     INLNAHNSYSFYTPDDDGTGTKFKGMIVFDLVMLYLTNLPALAHDSLLLSNVSYQATE
                     ALLKLYDQSRSLNKQVFLAFDKASSYSPDANQLLSENTVLRLSSNGNELYGISWNKGE
                     NSDEI"
     gene            5017..5226
                     /locus_tag="VHC05_001624"
     CDS             5017..5226
                     /locus_tag="VHC05_001624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEQ5402910.1"
                     /translation="MRFSYNKLWKLLIDKGWTKTKLRQEAGISSSTIAKLGKGENITT
                     DILLEICIALDCKIEDIVEIVDNNI"
     gene            complement(5328..6467)
                     /locus_tag="VHC05_001625"
     CDS             complement(5328..6467)
                     /locus_tag="VHC05_001625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEQ5402911.1"
                     /translation="MFDFANNTFLAGLNPASLSLVAVYQSLESVIGVLFNLFGGVIAD
                     SFKRKKIIITTNILCGTACLVLSFLTKEQWLVYAIVLTNVILAFMSAFSSPSYKAFTK
                     EIVKKDSISQLNSLLETTSTVIKVTVPMVAIFLYKLLGIHGVLLLDGLSFLIAALLIS
                     FILPVNDEVVIKEKVTIREIFNDLKIGFKYVYSHKSIFIITVLSALVNFFLAAYNLLL
                     PYSNQMFGEISTGLYGTFLTAEAIGGFIGAILSGFVNKELSSMRLILFLSLSGLMLML
                     APPFYIMFHNAIILALSPALFSLFLSIFNIQFFSLVQKDVDNDFLGRVFGIIFTITIL
                     FMPIGTGFFSVALNPNNSFNLFIIGSCITILSLVFRILFKKYNIR"
BASE COUNT         2199 a         1301 c         1073 g         1907 t
ORIGIN      
        1 ccctagagta ttaaaactcc tagtcccttt gtttcaagct atttagaact tttattgtat
       61 tatccacttt attcctattt ctgttgctat tagtttaacc atgaaatcta acctttaccc
      121 tttttaggga gtgcaaaatc caaatgaatc gtgcatctca actcccaata taacttcttt
      181 cattatacca cagataaact aaaaaaggac gtgccgaatt gatacgccct tgccttttat
      241 caatcaatcc gtacgccatt tttgaaggtt aggctgatgt gcttgtctac ttttatatcc
      301 aacctttcaa cacttgtctg ccagagttct ccctttggac caggagttaa agagatggtt
      361 gtaaggtcag cttgtgtcgc tagactttcc cctctcacct ttaggagcgg tgtgtcaatg
      421 gaaagattcc catccctatc ccaactaaag actggagtat tctgtcctgg aataacgacc
      481 ttatcagctt caacttctag gctcttcaca tactctgata gaatctgttg ggagataagc
      541 cttgtcatcc atctgaacta gagacggtca actcatcaat cttagctttt tgaagtgctg
      601 caacttgtgc ttctaaggca tccgttgcca gataatcaag agcagctttc ttatcagaac
      661 gctcgccttc tgctttagca gtagcgatac cataccactt ttatctcgta taatctgcac
      721 ataggcattt ccccatatca aaagatggct catgattgcc tctcgaaaga taaaggagga
      781 catctctgga ttgggttcat catgaagaag aaagtacagt gggtggtcca gctttttctc
      841 cttcccattt tctgtccgtt catagatgtg aataggaaat gacgccaccg cttcagcaag
      901 aatacgcaca caggcataga ctgccgtcgt gtgcatagtc ttaaactcat ccacattctc
      961 gccactagtc gtgcgaccaa agaggtagga aaagtcctga ccttcataac tgttttgagg
     1021 cttatctcta gccctttttt ctaattaaat caagtagtcc cataagccct ccttattttg
     1081 gggtacaaaa aaagcacctc ctttgaagtg ctttcggtat atttctttca aagtaatcaa
     1141 cagtctttct tacaaaacct agtattctca ttctgtcaat tccttaaatg cgtcaagatg
     1201 tcgtgataat actgaagtcg caatctcatc taaccttgct tgttcaacaa ctgttgtcat
     1261 ctgctcatca ccaaagttcc atcagttgat ttataaaggt taaactcctg attctcttga
     1321 atgccaaata ggtcaggtat cggaggatag atgtcatcac caatttgtat cgtctttacg
     1381 agttccatac atcactctcc cttactttac caattattca tatgacgtga tccatagacg
     1441 accgcaacaa ttataacttc atcttccaga acatgatata caatgcgata ttttttgaca
     1501 atcagttgtc tgaaggtata gccttttcca atcagatcct caatgatggc acaacgttca
     1561 ggaaaaatgg atagtgataa cattccttgg gataacctct caagaagatt atccgctgcc
     1621 tgtggtgcac agagttcatc acgaacatag tgatagatgc tcagcaaatc tgctttagca
     1681 tcatccgaca tggtgacctg atattctttc attaagcatt ttccttcaat tgaaatagaa
     1741 attctctgac atcctgacgg ttgccagttt tcgcatcttc aaagctggtg ataagcttat
     1801 cataaaactt ctcctgactc atgtaatcaa cattaactcg ttgaggcgct tcaggtagag
     1861 aaacatcaaa tgggatgccc ccagtcaaaa taatctgatt caaaaacata tcaatcgcag
     1921 ttgacatagg aatacctaag cgtttcaaaa tatcatctgc cgcacttttt actgaatcat
     1981 caactcgtaa attcaaagtt cccgttttag ccatggttat tctccttatt tgtaacgaca
     2041 ttgtatcaca tttttggagt tgattcaact aaaaactcaa tatccctcgc tcatcataga
     2101 cgctagcttc atcaccttgg cggcgaatgc aacggtcaag ccccaggata agacctacaa
     2161 taccgtcaat cttctcaaca gatttttcct tatctggctt gatgttgcct gcaggggctt
     2221 gtcgcatcac cacgttttgt cccatccatt taaggactgg atgaccaaca tgttggattt
     2281 tccctaccat catgagttta tagagttcct tggacggtgg actcatatcc ttataaccct
     2341 gcccaaaagg caccatggtc aagtcgacac cgcaattcca aggtatcttc tggtaaccat
     2401 cagagagaag acagggattg taaaattaac cactgtgcaa aatacagcgt tcactaccca
     2461 gtcgaatcaa ctcaaaaaac aatacgggca gttcttgtta acagaatcta ataactgttg
     2521 tgtatgccca ggctgtgata gaccactcat tctaaccagt ggcaacttag cagcagaaaa
     2581 ttacgaggtt tcagccattg aaaaagataa ggacgctgaa gcactgaatc tgatagtcct
     2641 ctgcccagat tgttttttaa cctatcaagc agatagtcgc aaaaaaattg taacagctct
     2701 aaaaaatgtt aaaaagattc tagtctctgc acataacagc caacaagcga tttctgatat
     2761 gaagttagac agtggaattg tttcagtttt gactagtctc aataaactaa aatgtgatga
     2821 atatgatatc tcctatgact cgaagcaatt gactgataag atatcacctg agaacaatcg
     2881 tacgctttat caattggtta aaaacccagt tattgataac tacttaacca ttcaaaaaat
     2941 catcgtaaat ttggacaaac aaggaaaaat tgattacgag gaaatccaat atcaaacgcg
     3001 atcgatgtat aaaaagttaa aagcagccaa gcataataat ctggctattt tcaatactat
     3061 ttcggaaaaa ctccatatgg ctacactaca ggacatctac ttctgccaga tgattgtctc
     3121 ttactttatc caaaaatgcg aggtacttga ataatgcaat taccaaataa actttactcc
     3181 tatcaaaaaa gcactctggc ctatttacct agagtgctaa atgaaatcaa aagtggaaac
     3241 tcaaacgtca aagatatctt tcacgctatc tcagaagagt tggatgatcc tacagatttc
     3301 ctatccataa tggattgctt gtatgcattg aacgctattg aaatgtctaa tgaaggagaa
     3361 gtaaaattat gcttatagaa atgtggtctc cagtatttaa gaaacacgga gaaattcggg
     3421 aaccaatctg ctttcaccat gggctaaacg tgattatggg gatggattta gctgataact
     3481 ctatcggcaa atcctcctca ctattagcca ttgatttcat ctttggaggt aatagctatc
     3541 taaaatcaat tgcggttaaa aaattaggtg atcatcctat ctacttctgc tttcaatttg
     3601 agaaaaagtt ttatttttca agagatacgg ccaacccaga tatcattcta gtgtgtgaca
     3661 agagctactc tccaaccggt gaaacaatgg acctaggaat ttttcttaac agacttaaga
     3721 aacgatatca tttagattct ccagagctat cattccgatt agctatgagt ggcttcttta
     3781 ggattgcagg aaaaagtaat caaaataccg atttcccctt acaagtttat tcgagccaaa
     3841 aatcttctga atctattact actctcatcc aactgtttaa tttgtatgat aacattgcac
     3901 gatacaaaga acgtctgaaa gataagagcg accagttaac aacttttcgt aatgctcgaa
     3961 agtatatctt catctccaac ctggttggcg gtaaaaagca atttgaagca aatgtctcag
     4021 aaataaaaag attggaatat gatttagcac atctccaaga tactcagcaa gataaaattg
     4081 actctgatga tatttaaaaa aatcaacaaa aactccaact tagaaatact aagctggagt
     4141 tagaaagcag tcttcgggac aagcaaagac gtcttaagct attggacatc agtatcgaat
     4201 ttggcttata tcctactgaa tctgacttaa cagagcttca acaatacttc ccagatacta
     4261 atctcaaaaa attatatgaa gttgaagctt accacaaaaa attggaaact attttagatt
     4321 ccgaattctc aactgaacgt gaatccctaa tagctgagat cgacgaatta gagagtcaat
     4381 taacaactct aaaccaagaa cttcaagaac taggaaacat cccaaatctt tcaagtgagt
     4441 acttagaaag ctactctaaa ctaacagcta caatcaatgc actaaaagaa caaaacgagg
     4501 cctacttaaa ggagtctggt ctacccaaag aaaaatcagg agcggacgct gacttgaaac
     4561 gcagtacaga agatatcctt ctagatctag aagtaaaaat caacagtaag atgcgtgaat
     4621 tcaataacat tctatatcca gatattcgca aagctcctca aattaacctc aatgctcaca
     4681 atagctactc cttctataca ccagatgatg atggtacagg aactaagttc aaagggatga
     4741 ttgtattcga cttagtaatg ctctacctta ctaatctgcc agcactcgca cacgattcat
     4801 tactcttgag taatgttagc taccaagcga ctgaagcact tttgaagctg tatgaccagt
     4861 caaggtcatt gaacaaacaa gtctttttag ccttcgataa agccagctct tattctccag
     4921 atgctaatca actcttgtca gaaaatacgg tattgagact ctctagtaac ggaaatgaac
     4981 tctacggtat ttcatggaac aaaggagaaa actcagatga gatttagtta caataaatta
     5041 tggaaacttc ttattgataa aggttggacc aaaacaaagc tcaggcaaga agctgggatt
     5101 agttcttcca cgatcgcaaa attgggaaaa ggggaaaata tcactactga tattttattg
     5161 gaaatttgta ttgcacttga ttgtaagatt gaagatatag tagaaattgt agataataat
     5221 atctagaaat aaaaaaagca ctaagttgat aagatgtgta agtcagatca acttagtgcc
     5281 tttactttga aaaaaataat tttctcaata atacttagta ctaactgtta acgaatatta
     5341 tactttttaa ataatattct aaatactaat gacaatatag taatgcacga accaataata
     5401 aaaagattaa agctattgtt aggatttaat gctaccgaga aaaagccagt cccaataggc
     5461 ataaaaagaa tagttattgt aaagataata ccaaacactc tccctaaaaa atcgttatca
     5521 acatctttct ggacaagaga aaaaaattga atattaaaga tggaaagaaa taaactgaat
     5581 aaagctggtg acaaagctaa aataattgca ttatgaaaca taatataaaa tgggggagct
     5641 aacattaaca tcagtcctga taaagataga aacaatatca atctcatact tgataattct
     5701 ttattcacaa aaccacttaa tattgcccca ataaatccac caattgcttc tgctgttaaa
     5761 aaagtgccat aaagtccagt tgaaatttct ccaaacattt gattactata gggcaacaat
     5821 aaattataag cggctagaaa aaaattaaca agtgcagaaa gaacggtaat aataaagatg
     5881 gacttatggc tgtaaacata tttaaatcct atttttaaat cgttaaatat ttctctgatt
     5941 gtcaccttct cctttatcac cacttcgtca ttaacaggta aaataaagga aattagtaaa
     6001 gcagctatta gaaatgatag tccatccaat agtaatacac cgtgtatacc aagtagctta
     6061 tataagaaaa ttgctaccat aggaactgtt actttgatta cagtacttgt tgtctctagc
     6121 aatgaattaa gttgtgatat actatctttt ttaacaattt cttttgtaaa tgctttatag
     6181 gatggactag aaaaagcact cataaatgcc aagataacat tagttagtac aatggcataa
     6241 accaaccatt gctcttttgt taggaacgag agtactaagc aagctgtgcc acataagata
     6301 tttgtagtaa taataatttt tttccgcttg aaactgtctg caatgactcc accaaataaa
     6361 ttaaatagaa cacctatgac actttctaga gactgatata ctgcaactaa tgatagagac
     6421 gctggattaa gcccagcaag aaaagtattg ttagcaaaat caaacataac atcgccaatt
//
LOCUS       DAUDWO010000059         6462 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.060, whole genome shotgun sequence.
ACCESSION   DAUDWO010000059 DAUDWO010000000
VERSION     DAUDWO010000059.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6462)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6462)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6462
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.060"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(12..2171)
                     /gene="nrdE"
                     /locus_tag="VHC05_001626"
     CDS             complement(12..2171)
                     /gene="nrdE"
                     /locus_tag="VHC05_001626"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HEQ5402912.1"
                     /translation="MSLKDLGDISYFRLNNEINRPVNGKIPLHKDKEALKAFFAENVL
                     PNTMSFTSITEKIEYLISNDYIESAFIQKYHPEFITELASIIKSENFRFKSFMAAYKF
                     YQQYALKTNDGEHYLENLEDRVLFNALYFADGQEDLAKDLAVEMINQRYQPATPSFLN
                     AGRSRRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGY
                     AGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIIAFLSTKKENADEKVR
                     VKTLSLGITVPDKFYELARKNEDMYLFSPYNVEKEYGIPFNYLDITNMYDELVANPKI
                     TKTKIKARDLETEISKLQQESGYPYIINIDTANKTNPIDGKIIMSNLCSEILQVQTPS
                     LINDAQEFVEMGTDISCNLGSTNILNMMTSPDFGRSIKTMTRALTFVTDSSSIEAVPT
                     IKHGNSQAHTFGLGAMGLHSYLAQHHIEYGSPESIEFTDIYFMLLNYWTLVESNNIAR
                     ERQTTFVGFENSKYADGSYFDKYVTGHFVPKSDLVKSLFKDHFIPQASDWEALRDAVQ
                     KDGLYHQNRLAVAPNGSISYINDCSASIHPITQRIEERQEKKIGKIYYPANGLSTDTI
                     PYYTSAYDMDMRKVIDVYAAATEHVDQGLSLTLFLRSELPMELYEWKTQSKQTTRDLS
                     ILRNYAFNKGIKSIYYIRTFTDDGEEVGANQCESCVI"
     gene            complement(2191..2409)
                     /locus_tag="VHC05_001627"
     CDS             complement(2191..2409)
                     /locus_tag="VHC05_001627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redoxin NrdH"
                     /protein_id="HEQ5402913.1"
                     /translation="MITVYSKNNCMQCKMTKKFLEQHGANFQEINIDEHPEKVDYVKS
                     LGFTSAPVIETDNLVFSGFQPAKLKELI"
     gene            2802..3065
                     /locus_tag="VHC05_001628"
     CDS             2802..3065
                     /locus_tag="VHC05_001628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019775469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphocarrier protein HPr"
                     /protein_id="HEQ5402914.1"
                     /translation="MASKDFHIVAETGIHARPATLLVQTASKFASDITLDYKGKAVNL
                     KSIMGVMSLGVGQGADVTISAEGADAEDAIAAIEETMTKEGLA"
     gene            3070..4803
                     /gene="ptsP"
                     /locus_tag="VHC05_001629"
     CDS             3070..4803
                     /gene="ptsP"
                     /locus_tag="VHC05_001629"
                     /EC_number="2.7.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="HEQ5402915.1"
                     /translation="MTEMLKGIAASDGVAVAKAYLLVQPDLSFETVTVADTNAEEARL
                     DVALQAAQDELSVIRENAVESLGEEAAAVFDAHLMVLADPEMISQVKETIRAKQTNAE
                     TGLKEVTDMFITIFEGMEDNPYMQERAADIRDVAKRVLAHLLGVKLPNPATINEESIV
                     IAHDLTPSDTAQLNKQFVKAFVTNIGGRTSHSAIMARTLEIAAVLGTNDITKRVKDGD
                     VIAVNGITGEVIIDPSEDQVLAFKEAGAAYAKQKAEWSLLKDAHTETADGKHFELAAN
                     IGTPKDVEGVNGNGAEAVGLYRTEFLYMDSQDFPTEDEQYEAYKAVLEGMNGKPVVVR
                     TMDIGGDKELPYFDLPKEMNPFLGFRALRISISETGDAMFRTQMRALLRASVHGQLRI
                     MFPMVALLKEFRAAKAVFDEEKANLLAEGVAVADDIQVGIMIEIPAAAMLADQFAKEV
                     DFFSIGTNDLIQYTMAADRMNEQVSYLYQPYNPSILRLINNVIKAAHAEGKWAGMCGE
                     MAGDQQAVPLLVGMGLDEFSMSATSVLRTRSLMKKLDSAKMEEYANRALTECSTAEEV
                     LELSKEYVSED"
     gene            4988..6415
                     /locus_tag="VHC05_001630"
     CDS             4988..6415
                     /locus_tag="VHC05_001630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019322885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent glyceraldehyde-3-phosphate
                     dehydrogenase"
                     /protein_id="HEQ5402916.1"
                     /translation="MAKQYKNLVNGEWKLSENEITIYAPATGEELGSVPAMTQAEVDA
                     VYASAKKALSDWRALSYVERAAYLHKAADILVRDAEKIGAILSKEVAKGHKAAVSEVI
                     RTAEIINYAAEEGLRMEGEVLEGGSFEAASKKKIAIVRREPVGLVLAISPFNYPVNLA
                     GSKIAPALIAGNVVALKPPTQGSISGLLLAEAFAEAGIPAGVFNTITGRGSVIGDYIV
                     EHEAVNFINFTGSTPIGEGIGKLAGMRPIMLELGGKDSAIVLEDADLALAAKNIVAGA
                     FGYSGQRCTAVKRVLVMDKVADQLAAEIKTLVEKLSVGMPEDDADITPLIDTSAADFV
                     EGLIKDATDKGATALTAFNREGNLISPVLFDHVTTDMRLAWEEPFGPVLPIIRVTTVE
                     EAVKISNESEYGLQASIFTTNFPKAFGIAEQLEVGTVHLNNKTQRGTDNFPFLGAKKS
                     GAGVQGVKYSIEAMTTVKSVVFDIQ"
BASE COUNT         2014 a         1155 c         1360 g         1933 t
ORIGIN      
        1 ttcttaacca attaaatgac acaagattca cattggtttg cgcccacttc ttccccatca
       61 tccgtaaagg tacggatata gtagatagat ttaatgcctt tattgaaagc gtagtttcgt
      121 aagatggata aatcacgagt ggtttgtttg ctttgtgttt tccactcata aagctccata
      181 ggcaactcac tacgaaggaa tagagttaat gacaagcctt ggtccacatg ttcggtcgca
      241 gcggcataga catcaataac tttgcgcatg tccatatcgt aagcagatgt atagtaagga
      301 atggtatccg tagacaaacc atttgcagga tagtagattt taccaatttt cttttcttga
      361 cgctcttcga tgcgttgtgt gattgggtga atagaagcag agcagtcatt gatataagaa
      421 atagagccat ttggagcaac tgctagtcgg ttttgatgat aaagaccatc tttttgaacg
      481 gcgtcgcgaa gagcctccca atctgaagct tgcggaataa aatggtcttt aaagagactt
      541 ttgaccaaat cagattttgg aacaaagtgt cctgtaacgt atttatcaaa gtaactacca
      601 tcagcgtact tagagttctc aaagccaaca aaggtagttt ggcgctcacg agcgatgtta
      661 ttggattcga ccaaggtcca ataattcagg agcataaagt aaatatcagt aaactcgatg
      721 gattctggac tgccatattc aatatgatgt tgagcaaggt aagaatgtag tcccatagct
      781 ccaaggccaa aagtatgagc ttggctattg ccatgtttaa tggttggaac agcttcaatg
      841 cttgatgaat cagtaacaaa agttagggca cgtgtcatgg tcttaataga acggccaaag
      901 tctggtgagg tcatcatgtt caggatatta gtggaaccta agttacatga aatatcagtt
      961 cccatttcta caaactcttg cgcatcattg ataaggctag gtgtttgaac ttgtaaaatt
     1021 tcagaacaca agttgctcat gatgattttt ccatcgatag gattagtttt attagctgta
     1081 tcaatattga tgatataagg gtaaccagat tcttgttgta attttgaaat ctctgtttca
     1141 agatcacgag ctttaatttt agtcttagta attttagggt tcgccactaa ctcatcgtac
     1201 atattggtaa tgtcgagata gttaaaggga atgccatatt ctttttcaac attgtaagga
     1261 ctaaagagat acatgtcctc gtttttacga gctaattcgt agaatttatc aggaacggta
     1321 atccctagtg acaaggtttt aacacgcacc ttttcatcgg cattttcttt tttagtagat
     1381 aagaaagcaa tgatatcagg atgaaaaaca tttaggtaaa caacaccagc tccttgacgt
     1441 tgcccaagtt gatttgaata agaaaaacta tcttcaaata atttcataac aggaacaact
     1501 cctgaggctg caccagcata gcctttgatt ggtgcgccag cttcacggag gttagacaag
     1561 gtaatcccaa cacctccacc aatacgggat aattgcaagg cagagttaat ggaacgtccg
     1621 atagaattca tgtcatcagt tacttgaatc aagaaacaag agaccaattc accacgacgg
     1681 cttcgaccag catttaaaaa ggaaggagta gccggttggt aacgttggtt aatcatttca
     1741 acggctaaat cttttgctaa gtcttcttga ccatctgcaa aatacaaagc attaaacaag
     1801 acacggtctt caaggttttc taaataatgc tctccatcat ttgtttttaa ggcgtattgc
     1861 tggtagaact tgtaggctgc cataaatgat ttaaagcgaa aattttctga tttgattatg
     1921 ctagctaatt cagtaataaa ttcagggtgg tatttctgaa taaaagctga ttcaatgtaa
     1981 tcatttgaga ttaaatactc aattttttcc gtaatggaag taaaagacat ggtgtttggc
     2041 agcacatttt cagcgaaaaa agcttttaaa gcttctttgt ctttatgaag tggaatttta
     2101 ccattaacag gacggttaat ttcattattt aggcgaaaat atgaaatatc gccaagatct
     2161 ttgagactca tattattttt ccttgtctta ttaaatcaat tcttttaact ttgcaggttg
     2221 gaagccagaa aatacgaggt tatctgtttc gataacagga gcagatgtga agccaagact
     2281 tttcacataa tccacttttt caggatgttc atcgatatta atttcctgga agttggctcc
     2341 gtgttgttct aaaaatttct tagtcatttt gcactgcatg caattatttt tggaatatac
     2401 tgtaatcatg tcttgtcctt ctaaaattag taatggttcc atcttaaatg gaattactat
     2461 aatagcatat aaaaaataaa gctaaaaagc aagctataaa cttatctaaa acacaacata
     2521 ttgtgttgaa ataaaaaaca gaaacctaaa tattgtgtca atctggattc ttatggttag
     2581 agctctagcg ttttggtgat agaagctaag cagttttaat aaagtattaa agtttgaaaa
     2641 ataaattgtg aaaaacgtga aaataaaaga aaataatttc acattttttg tcgtttaaat
     2701 atttaatctt gaaaataaaa aagcattgtg ctataatcgg ttgttgtaag ggttatcatg
     2761 tgatggctca aaaatacaca acttaaaagg agaaccatac tatggcttca aaagactttc
     2821 acattgttgc agaaacaggt attcatgcgc gtccagcgac tttgcttgtt caaacagcta
     2881 gcaaatttgc ttcagacatc actcttgact acaaaggtaa agcagtaaat ctaaaatcaa
     2941 tcatgggtgt tatgagtctt ggtgttggtc aaggtgcaga tgttactatc tcagctgaag
     3001 gtgcagatgc tgaagatgcc attgcagcaa ttgaagaaac aatgactaaa gagggattgg
     3061 cataagacta tgacagaaat gcttaaagga attgcagcct cagacggcgt tgctgttgct
     3121 aaagcatatc tactagttca gccggatttg tcatttgaga ctgttacagt cgcagataca
     3181 aatgcagaag aagctcgcct tgatgttgca ctccaagctg cacaagacga gctttctgtt
     3241 atccgtgaaa atgcagtaga aagcttaggt gaagaagcag cagccgtttt tgatgcccat
     3301 ttgatggttc ttgctgatcc agaaatgatt agccaggtta aagaaacgat tcgcgcaaaa
     3361 caaacgaatg cagaaacagg tcttaaagaa gtgactgaca tgttcatcac catctttgaa
     3421 ggcatggaag ataacccata catgcaagaa cgtgcagcgg acattcgcga cgttgcaaaa
     3481 cgtgtgttgg ctcacctttt aggtgtaaaa cttccaaatc cagctacaat caatgaagaa
     3541 tccatcgtta tcgcacacga tttgacacct tcagatactg ctcaacttaa caaacaattt
     3601 gtaaaagcat ttgttacaaa tatcggtggt cgtacaagtc actcagctat catggcacgt
     3661 acacttgaga tcgctgcggt acttggaaca aatgatatta caaaacgtgt taaagatggt
     3721 gatgtgattg ccgttaatgg tatcactggt gaagtgatta tcgatccaag cgaagatcaa
     3781 gtacttgctt ttaaagaagc tggtgcggct tatgccaaac aaaaagcaga gtggtctctc
     3841 cttaaagatg cgcatactga aacagctgat ggcaaacact ttgaattggc tgctaatatc
     3901 ggtacaccta aagacgttga aggtgttaat ggcaatggcg ctgaagctgt tggcctttac
     3961 cgtactgagt tcttgtacat ggattctcaa gacttcccaa ctgaagacga acaatacgaa
     4021 gcttacaagg cagtgcttga aggcatgaat ggcaaacctg ttgtggttcg tacgatggat
     4081 attggtggcg acaaggaact tccttacttt gaccttccaa aagaaatgaa tccattcctt
     4141 ggtttccgtg ctcttcgtat ttccatctct gaaactgggg atgccatgtt ccgcacacaa
     4201 atgcgtgcgc ttcttcgtgc ctctgttcac ggacaacttc gtattatgtt cccaatggtt
     4261 gcccttctta aagaattccg tgctgcaaaa gcagtctttg atgaagaaaa agcaaacttg
     4321 cttgcagaag gcgttgcggt tgctgatgac atccaagttg gtatcatgat tgagattcct
     4381 gcagctgcta tgcttgcaga ccaatttgct aaggaagttg atttcttctc aattggaaca
     4441 aacgacctta tccaatacac tatggcagca gaccgtatga acgaacaagt atcatacctt
     4501 taccaaccat acaacccatc aatattacgt ttgatcaaca atgtgatcaa agcagcgcac
     4561 gctgaaggta aatgggcagg tatgtgtggt gagatggcag gtgaccaaca agctgttcca
     4621 cttcttgtcg gaatgggctt ggatgagttc tctatgtcag caacttcagt acttcgtacg
     4681 cgtagtttaa tgaagaaact tgactctgct aagatggaag aatatgcaaa tcgtgcgctt
     4741 acagaatgtt caacagcaga agaagttctt gaactttcta aagaatacgt ttctgaagat
     4801 taacgggtta aagagttggt ttaaaccagc tcttttttgc tagctaaaaa tacaattact
     4861 ttttggtgtg aaatcatttg agttatcaaa taattatcag aattttcaga tatttagtgt
     4921 agccaaatct tgaattatat cggaaaagtg atagaataag attactatca taaaaggaga
     4981 taaaacgttg gcaaaacaat ataaaaattt agtgaacggt gaatggaaac tatcagaaaa
     5041 cgagattacc atttacgcac cagcaacagg tgaagagtta ggatcagttc cagcgatgac
     5101 gcaggcagag gtagatgctg tttacgcttc agctaaaaag gctctatcag attggcgcgc
     5161 cttgtcttat gtggaacgtg cagcttacct tcataaagcg gctgatattt tagtacgtga
     5221 tgctgaaaag atcggcgcga ttctttcaaa agaagtagcc aaaggtcaca aggcagctgt
     5281 cagtgaagtt attcgtaccg ctgaaatcat taattatgca gcagaagaag ggcttcgtat
     5341 ggaaggtgaa gttcttgaag gtggtagctt cgaagccgca agtaagaaga agattgctat
     5401 tgttcgtcgt gaaccagttg gtttagttct tgccatctca ccttttaatt atcccgttaa
     5461 cttggcaggt tctaaaattg ctccagccct tattgcagga aatgttgttg ctcttaaacc
     5521 accaacacaa ggctctattt ctggtttgtt actagcagaa gcttttgcag aagctggtat
     5581 tccagcaggt gtctttaata ccattacagg gcgaggttct gttattgggg attatatcgt
     5641 tgagcacgaa gcggttaact ttatcaactt tacaggttct actccaattg gggaaggaat
     5701 tggtaaatta gcgggtatgc gaccaattat gcttgagctt ggtggtaagg attctgctat
     5761 cgttttggaa gatgcagatc ttgctttagc agcgaaaaat attgtagccg gtgcttttgg
     5821 ttactcagga caacgttgta cagcggttaa acgcgttctt gtgatggaca aggtggcgga
     5881 tcaattggcg gctgagatta aaacccttgt tgaaaaacta agtgtcggaa tgcctgaaga
     5941 cgatgctgat attacaccat taattgatac atcagctgct gattttgttg aagggttgat
     6001 taaagatgca actgataagg gagctactgc tttgacagcc tttaatcgtg aaggcaatct
     6061 tatttcaccc gttctctttg atcatgtgac aactgacatg cgtttggcat gggaagagcc
     6121 gttcggccca gtattaccaa ttattcgtgt aaccactgta gaagaagccg tcaagatttc
     6181 taatgagtct gaatatggtt tgcaagcttc tatttttaca actaatttcc caaaagcttt
     6241 tggcattgct gagcaattag aagttggaac tgttcacctt aacaataaaa cacaacgtgg
     6301 aacagataat ttcccattct taggcgctaa aaaatcaggt gcaggggtac aaggagttaa
     6361 atattctatc gaagctatga caactgttaa atctgttgta tttgatatcc agtaataaaa
     6421 aaataaacaa aaagttaggt taacttaact ttttgtttat tt
//
LOCUS       DAUDWO010000060         6428 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.061, whole genome shotgun sequence.
ACCESSION   DAUDWO010000060 DAUDWO010000000
VERSION     DAUDWO010000060.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6428)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6428)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6428
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.061"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..186
                     /gene="speC"
                     /locus_tag="VHC05_001631"
     CDS             <1..186
                     /gene="speC"
                     /locus_tag="VHC05_001631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021733756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="streptococcal pyrogenic exotoxin SpeC"
                     /protein_id="HEQ5402917.1"
                     /translation="DATSPYVSGRIEIGTKDGKHEQIDLFDSPNEGTRSDIFAKYKDN
                     RIINMKNFSHFDIYLEK"
     gene            complement(254..1459)
                     /locus_tag="VHC05_001632"
     CDS             complement(254..1459)
                     /locus_tag="VHC05_001632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HEQ5402918.1"
                     /translation="MTFLDKIKQGCLDGWAKYKILPSLTAAQAILESGWGKHAPHNAL
                     FGIKADASWTGKSFNTKTQEEYQAGVITDIVDRFRAYDSWDESIADHGQFLVDNPRYQ
                     SVIGEADYKKACHAIKDAGYATASGYAELLIQIIEENNLQKWDKEAIVRKEKQMINSQ
                     CREVIEFFINLANAGMGVDKDSFAGWQCADVPCYAAKHWFDVDLWGNAIDLLDSAAAV
                     GWEVHRMPTDANPLTGAFFVQSVPYHQFGHTGIVIEDSDGYTMRTVEQNIDGNPDALY
                     VGAPARFNTRDFTGVIGWFYPPYQGDTVTQPVSTEPQTSETIVETAKTGTFTLDVAEI
                     NIRRWPSLASEVVGSYKQGDTVSFDNEGYANGYYWISYVGGSGMRNYLGIGQTDKDGN
                     RISLWGKLN"
     gene            complement(1575..1802)
                     /locus_tag="VHC05_001633"
     CDS             complement(1575..1802)
                     /locus_tag="VHC05_001633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016480475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin"
                     /protein_id="HEQ5402919.1"
                     /translation="MINLKLRLQNKVTLMAILGAIFLLAQQLGIKLPSNIADIANTAV
                     TLLVLLGVVTDPTTKGLSDSEQALTYHEPKK"
     gene            complement(1799..2074)
                     /locus_tag="VHC05_001634"
     CDS             complement(1799..2074)
                     /locus_tag="VHC05_001634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402920.1"
                     /translation="MATELIFGVGGFILAIVTTYNIFNAKSIKHATDITLLQSEVEHL
                     KIVTRQNARRLEEHAEQNKTLITMTEQIKNLTDDVKDLKDMMRGEIK"
     gene            complement(2084..2491)
                     /locus_tag="VHC05_001635"
                     /pseudo
     CDS             complement(2084..2491)
                     /locus_tag="VHC05_001635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054861.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(2521..3777)
                     /locus_tag="VHC05_001636"
                     /pseudo
     CDS             complement(2521..3777)
                     /locus_tag="VHC05_001636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011527558.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tape measure protein"
     gene            complement(3779..3928)
                     /locus_tag="VHC05_001637"
                     /pseudo
     CDS             complement(3779..3928)
                     /locus_tag="VHC05_001637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003052415.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
     gene            complement(4200..4382)
                     /locus_tag="VHC05_001638"
     CDS             complement(4200..4382)
                     /locus_tag="VHC05_001638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008087492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402921.1"
                     /translation="MEKLTLKKEKENTATLPFFVGIDLHAQIKEISTETGIPMRRIIE
                     RMIRFSLDNLEIMEGD"
     gene            complement(4370..4582)
                     /locus_tag="VHC05_001639"
     CDS             complement(4370..4582)
                     /locus_tag="VHC05_001639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011527540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402922.1"
                     /translation="MDQYLINDNEFLRDENTRLNKEFSELNHAVAKANLLDVIIEDGY
                     ILQSTLDKCTAKLDEIDQKELKTWKN"
     gene            4667..5143
                     /locus_tag="VHC05_001640"
                     /pseudo
     CDS             4667..5143
                     /locus_tag="VHC05_001640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011527534.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PH domain-containing protein"
     gene            5309..>6428
                     /locus_tag="VHC05_001641"
     CDS             5309..>6428
                     /locus_tag="VHC05_001641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEQ5402923.1"
                     /translation="MYSRVSTINQAEEGYSIQGQIEALTKYCEAMEWKIYKNYSDAGF
                     SGGKLERPAITELIEDGKNNKFDTILVYKLDRLSRNVKDTLYLVKDVFTANNIHFVSL
                     KENIDTSSAMGNLFLTLLSAIAEFEREQIKERMQFGVMNRAKSGKTTAWKTPPYGYRY
                     NKDEKTLSVNELEAANVRQMFDMIISGCSIMSITNYARDNFVGNTWTHVKVKRILENE
                     TYKGLVKYREQTFSGDHQAIIDEKTYNKAQIALAHRTDTKTNTRPFQGKYMLSHIAKC
                     GYCGAPLKVCTGRAKNDGTRRQTYVCVNKTESLARRSVNNYNNQKICNTGRYEKKHIE
                     KYVIDVLYKLQHDKEYLKKIKKDDNIIDITPLKKEIEII"
BASE COUNT         1917 a         1333 c         1154 g         2024 t
ORIGIN      
        1 gacgctactt ctccttatgt aagcggcaga atcgaaattg gcacaaaaga tgggaaacat
       61 gagcaaatag acttatttga ctcaccaaat gaagggacta gatcagatat ttttgcaaaa
      121 tataaagata atagaattat caatatgaag aactttagtc atttcgatat ttatcttgaa
      181 aaataattca tcatacacaa aaaaccgccc agaataatct gagcggtttt gtcttatctc
      241 ggagctttac ctcctaattt aatttacccc aaaggctgat gcgattccca tctttatcag
      301 tctgtccaat acctaggtag ttacgcatac ctgagccgcc aacatagcta atccagtagt
      361 aaccgttggc ataaccctca ttgtcaaagc tgacagtatc accttgctta tagctaccta
      421 ctacttcact ggctaggctt ggccagcgtc tgatattgat ctctgcaaca tcaagggtaa
      481 aggtgcctgt ttttgctgtc tccacgatcg tttcagaagt ttgcggctcg gtgctgactg
      541 gttgcgtgac tgtatcccct tgatatggtg ggtaaaacca acctatcacg ccagtaaagt
      601 cacgagtgtt aaaacgagct ggtgcaccga catacaaagc atcaggattg ccatcaatgt
      661 tttgctcgac agtgcgcatg gtgtaaccgt cactatcctc gataacaatt cccgtatgtc
      721 caaattggtg atacggcact gattggacaa aaaatgctcc cgtcagtgga tttgcatctg
      781 tcggcatgcg atggacttcc caacctacgg cagcagcgct atctagtaag tcaatcgcat
      841 ttccccaaag gtcgacatcg aaccagtgct ttgctgcata acaaggcaca tctgcacatt
      901 gccagcccgc aaaactatct ttgtcaacac ccataccagc attggccaaa ttaataaaaa
      961 attcaatgac ttctcgacat tgagaattaa tcatttgctt ctcctttctg acaatagcct
     1021 ctttatccca tttctgcaag ttattctcct caataatttg gataagtagc tccgcatagc
     1081 cactcgcagt cgcatagcct gcatctttta tagcatgaca agctttttta taatcagcct
     1141 ccccaataac agactggtag cgtggattat ctactaaaaa ttgtccatgg tcagcgatag
     1201 attcatccca gctgtcatag gctctaaacc tgtcaacaat gtcagtaata acaccagctt
     1261 gatattcctc ttgggttttg gtgttaaacg acttaccggt ccagcttgcg tctgccttaa
     1321 taccaaacaa agcgttatgt ggtgcatgtt taccccaccc gctctctaag atagcttgtg
     1381 ctgcggtcaa ggatggcaag attttgtact tagcccagcc atctaaacag ccttgtttaa
     1441 ttttatctaa aaaggtcatc tgtcctcctt atctaaaaac ggataaaaga taagagcaac
     1501 cacagataat ggcacataca gtattgcgat tgctataact aatgctaatc gtgtgattgc
     1561 tcgcatggct cctcctattt tttgggctca tggtaagtca atgcttgttc gctgtcagat
     1621 aagccttttg tagtaggatc tgtgacaacg ccaagcaaca ccaaaagcgt tacagctgtg
     1681 ttggcaatat ccgcgatgtt tgatggtaat ttaataccta attgttgcgc taacaaaaag
     1741 atagctccca aaatagccat caaggttact ttgttttgta gtcgtaattt taaattgatc
     1801 atttgatttc tcctctcatc atatctttta aatctttaac atcatctgtt aaatttttaa
     1861 tttgctctgt cattgtgatg agcgttttgt tttgctcagc gtgctcttca agccgccgag
     1921 cattttggcg tgtaacaatt tttaaatgct ctacctcaga ttgcaacaaa gtaatatctg
     1981 tcgcatgctt gatggatttt gcattaaaaa tattgtaagt cgtgacgata gctaaaataa
     2041 agccaccaac gccaaatatc aactctgttg ccataaacca cctctaatct tgtttaacca
     2101 aatcagcgta cttgataact gttactttgg cttctgactc tagctcctct aaggtttgtt
     2161 tgtcatactc aaatgcttcg ttaacgtgta cgaagactag gttcccttcg cctgcttcac
     2221 cgtcttcctc tttagtactg tcgaccaccg taaagacatc atacgcttga tactcacctt
     2281 ttttggctgg ctcgattagc tcaagcatgc ctttataaat gtcagaatca atcttgccgc
     2341 cgctcattaa catgtggatc gtttgtaagt taatcatctt ttgcgtgcgc tctgcggaca
     2401 ccttagctag tccagcagct gtttgagcag ttttggcagt cttagcggtt tcctgtgaga
     2461 ttttttcaag gtcgtctagt tccgttaaac tcaatgtatc tcactaagct aacctccctt
     2521 agcggtatta cgtgataaaa ctttcaacgt ttcaccggat ttttcggtat agtaagccat
     2581 tttgcgataa gcgtcatcat agctaatgcc aagcttctga gccatatctg acgccatttg
     2641 acttatgccg cggtggattt cctcttgact tttaccagat tcttttaacc gttggactcg
     2701 ctccctctgg atagcaagat actgatcatt caaagctttg gtttttaggt tgtgctgcat
     2761 attaagttcg gtaagtctat tcaaaacttc ctgtctagca gccaactctt cagcactcaa
     2821 tttactagtg tcgctgccaa attgcttcaa aatctctttt aactctgctt tttttgtttt
     2881 atatgcagaa ttttctttat cgagcatctt aacagtgttt tcagatactt tttccaactg
     2941 ccttgcattt agcgcatcta actcgttatt caaagctgct gttaaagctt tcttttctga
     3001 tgcagaaaac ttcattaaat caagttgagc aataatcatt tctctctgat ttcgcaaaac
     3061 aagttctttt tcagcgcttg acaactggct catgtcacca ttgtgcttct ccatgattgc
     3121 tttaatctgg gtgttcatgc ttttaacatt gttaactact gattcagttt tggatttcaa
     3181 agcatttatg gtttcttctg acaatcctaa ttttttagct aagtttatat tcttatctaa
     3241 ttttgattga gctaactttt caatacttcc gaccaaatca tcaaaagctt cagtcacttt
     3301 cttaacgcta cctgcgcctg cctcgaacat ttgcaaagaa gtgttagttt cgtcaacttt
     3361 tttcttaaag ttacttagtg cagttgcttc tgtcgcggaa acagcggttc cccactcttc
     3421 cgtgcgtttt tgggctttat acatgctatc agcaattaaa ccaataccaa taacagctgc
     3481 gccacctagc aaaacacccc acgttaccgg gttgcttaat aaggcaaccg cgccagtcaa
     3541 actgcccata gaagctgtgg cagcttcagc tccaacactt gctgctactg caccggcttt
     3601 aaacgtgcgt agccaaccag ataaagcacc aatccctttg ctcatcttgc cgatagcttg
     3661 aatggttccg ccgataacac caataccctt acccaaaata gataaagccg gcccagcggc
     3721 ggctgcaata agtccccact tgataatttg ctgttgttgc tctttgtcga gcgagttatt
     3781 ttaagtgtgg tgggtcgaag acaacaaggt taaagctatt actttcaaaa ggcatatcac
     3841 gaaaatcacc aattacatca gggttgacat tgattttttt gccgtgcatc tcaaattttt
     3901 cttgtctgac gtccataaaa gttgtgtgag gttcgccgac ttcttgttct atggcttctg
     3961 ttaattttcc agttcttaat tggatagttg tatttgatat accaccgtat ctatcattgt
     4021 aatctggtgc gataatcatt tttttatgtt tgttaatgta gattctcaat cgtaagccct
     4081 cgcttcccat gtgatttgcg gatcgggttc tttacagcaa gggcattcca agtccttgta
     4141 tgctgatatg tttgaccatt ttttgccgca attttcgcaa taatattcaa agctatacat
     4201 taatcccctt ccatgatttc taggttatca agagaaaacc taatcattct ttcaataatt
     4261 cttctcattg ggatacctgt ttctgtcgag atttctttga tttgggcgtg taaatcaatc
     4321 cctacaaaaa acggtaatgt tgcagtattt tctttttctt tttttaaagt tagtttttcc
     4381 atgttttcaa ctccttctga tcaatctcat caagcttagc agtacatttg tccagcgtgc
     4441 tttgcaggat atatccatcc tcgatgatga catctaataa atttgcttta gcaaccgcat
     4501 gatttaactc gctaaactct ttgttgagtc gtgtgttttc gtctcttaaa aattcgttat
     4561 cattgattag gtattgatcc attctttcct cctaccaaat ttgtttagca ggcaaaccgt
     4621 gtttttggtt atatctacgt gtattggctt cccaaccgtt gttttcaaag aagtaaaagc
     4681 tttgccagaa attttgtcag atgacgaaat tatccaatac gcaacatctg ggtttgtaaa
     4741 cggcaatact gtccttgttg tattgaccca aaaacgaatt ttatttatcg ataagggaat
     4801 gttatatgga attagatcga cagaaattcc tcttgatatg gttaatagcg tctcatactc
     4861 taaaggttta attcttggcg caatagctgt tatgaacgga gccacaaaaa ttgaaatatc
     4921 taatattgcc aaggacactt gccctgtact taccgaaaaa ataaaagatt gtgtagaaca
     4981 atacaaatat aatctgtacc aacatcaatc gcctcagaaa acagcaactg taggctcgga
     5041 agatgccgtt gctgaaatcc gtaagtttaa aaaactttat gatgaaggca tccttacaga
     5101 ggaagagttt atagctaaga aaaaaataat tttagggatt taaggtgtaa agttaaccgt
     5161 taaaaaataa aaaagcccca cgctctcaaa ctttggcgag tctgagcgtg aggcgaattc
     5221 tagtatagta aaaacctgct ttaagtaggt ctctttacta tacctatttt aacagaaaat
     5281 gaggtaaaaa acaaagagaa aagtagctat ttactctaga gtatcaacaa taaatcaagc
     5341 cgaagaagga tattccattc aaggacagat tgaagcttta acaaagtatt gtgaggcaat
     5401 ggaatggaaa atttacaaaa actactctga tgcaggtttt tcaggcggta aacttgaacg
     5461 accggcaata acagaattga ttgaagacgg taaaaacaat aaatttgata ctattttagt
     5521 ctataaacta gacaggctat caagaaatgt aaaagacaca ctttacttag tcaaagatgt
     5581 atttactgct aacaatatcc attttgtcag cttaaaagaa aatatcgaca cttcttcagc
     5641 aatgggaaat ctctttctca ctctcttgtc agctattgca gagtttgaaa gagaacagat
     5701 taaagagcga atgcagtttg gtgttatgaa tagagcaaaa tctggaaaaa caacggcttg
     5761 gaaaacacca ccttatggat atagatacaa caaagacgaa aaaacattgt cggtcaacga
     5821 gttagaggct gctaatgtca ggcagatgtt tgacatgata atctctggct gctcaatcat
     5881 gtcaattaca aattacgcga gagacaattt cgtcgggaat acgtggacac atgtaaaagt
     5941 aaaaagaata ttagaaaacg aaacatataa aggattagtg aagtataggg aacaaacttt
     6001 ctcaggtgat catcaagcca ttatcgacga aaaaacatat aataaagcgc aaatagcttt
     6061 agcacatagg acagatacga aaacaaatac tagacctttt caagggaaat atatgctttc
     6121 tcacatagca aaatgcggtt attgtggtgc ccctttaaaa gtatgcacag gaagagctaa
     6181 gaacgatggt acgagaaggc aaacttacgt ttgtgttaat aaaacagaaa gtttggctag
     6241 acgaagtgtt aataattata ataaccaaaa gatttgtaac actggtcgat atgaaaaaaa
     6301 acacatcgaa aaatatgtta ttgatgttct ttataaactt caacacgata aagaatatct
     6361 taaaaaaata aaaaaagatg acaatataat tgatattaca cctttaaaaa aagaaataga
     6421 gataatcg
//
LOCUS       DAUDWO010000061         5971 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.062, whole genome shotgun sequence.
ACCESSION   DAUDWO010000061 DAUDWO010000000
VERSION     DAUDWO010000061.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5971)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5971)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5971
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.062"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            122..4237
                     /gene="cas9"
                     /locus_tag="VHC05_001642"
     CDS             122..4237
                     /gene="cas9"
                     /locus_tag="VHC05_001642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922251.1"
                     /note="Cas9, originally named Csn1, is the large,
                     multifunctional signature protein of type II CRISPR/Cas
                     systems. It is well known even to general audiences
                     because its RNA-guided endonuclease activity has made it a
                     popular tool for custom editing of eukaryotic genomes;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CRISPR RNA-guided endonuclease Cas9"
                     /protein_id="HEQ5402924.1"
                     /translation="MDKKYSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIK
                     KNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLE
                     ESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLADSTDKADLRLIYLALAH
                     MIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASRVDAKAILSARLSK
                     SRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLD
                     NLLAQIGDQYADLFLAAKNLSDATLLSDILRVNSEITKAPLSASMIKRYDEHHQDLTL
                     LKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLAK
                     LNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPY
                     YVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVL
                     PKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKE
                     DYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLT
                     LFEDKEMIEERLKTYAHLFDDKVMKQLKRRHYTGWGRLSRKLINGIRDKQSGKTILDF
                     LKSDGFANRNFIQLIHDDSLTFKEAIQKAQVSGQGHSLHEQIANLAGSPAIKKGILQS
                     VKVVDELVKVMGHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEH
                     PVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFIKDDSIDNKVL
                     TRSDKNRGKSDDVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAG
                     FIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFY
                     KVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGK
                     ATAKRFFYSNIMNFFKTEITLANGEIRKRPLIETNEETGEIVWDKGRDFATVRKVLSM
                     PQVNIVKKTEVQTGALTNESIYARGSFDKLISRKHRFESSKYGGFGSPTVTYSVLVVA
                     KSKVQDGKVKKIKTGKELIGITLLDKLVFEKNPLKFIEDKGYGNVQIDKCIKLPKYSL
                     FEFENGTRRMLASVMANNNSRGDLQKANEMFLPAKLVTLLYHAHKIESSKELEHEAYI
                     LDHYNDLYQLLSYIERFASLYVDVEKNISKVKELFSNIESYSISEICSSVINLLTLTA
                     SGAPADFKFLGTTIPRKRYGSPQSILSSTLIHQSITGLYETRIDLSQLGSD"
     gene            4237..5106
                     /gene="cas1"
                     /locus_tag="VHC05_001643"
     CDS             4237..5106
                     /gene="cas1"
                     /locus_tag="VHC05_001643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000929484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II CRISPR-associated endonuclease Cas1"
                     /protein_id="HEQ5402925.1"
                     /translation="MAGWRTVVVNTHSKLSYKNNHLIFKDAYKTELIHLSEIDILLLE
                     TTDIVLSTMLVKRLVDENVLVIFCDDKRLPTAMLMPFYGRHDSSLQLWKQMSWPEAVK
                     SEVWTTIIAQKILNQSCYLGACSYFEKSQSIMDLYHGLENFDPSNREGHAARIYFNTL
                     FGNDFSRDLEHPINAGLDYGYTLLLSMFAREVVVSGCMTQFELKHANQFNQFNFASDI
                     MEPFRPLVDKIVYENRNQPFPKIKRELFTFFSDTFSYNGKEMYLTNIISDYTKKVVKA
                     LNNEGKGVPEFRI"
     gene            5103..5444
                     /gene="cas2"
                     /locus_tag="VHC05_001644"
     CDS             5103..5444
                     /gene="cas2"
                     /locus_tag="VHC05_001644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endonuclease Cas2"
                     /protein_id="HEQ5402926.1"
                     /translation="MSYRYMRMILMFDMPTDTAEERKAYRKFRKFLLSEGFIMHQFSI
                     YSKLLLNNTANNAMIGRLREHNPNKGNITLLTVTEKQFARMIYLHGERNNCIANSDER
                     LVFLGEAFDES"
     gene            5434..>5971
                     /gene="csn2"
                     /locus_tag="VHC05_001645"
     CDS             5434..>5971
                     /gene="csn2"
                     /locus_tag="VHC05_001645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II-A CRISPR-associated protein Csn2"
                     /protein_id="HEQ5402927.1"
                     /translation="MNLNFPLLDEPIPLRGGTILVLEDVCVFSKIVQYCYQYEEDSEL
                     KFFDHKMKTIKESEIMLVTDILGFDVNSSTILKLIHADLESQFNEKPEVKSMIDKLVA
                     TITELIVFECLENELDLEYDEITILELIKCLGVKVETQSDTIFEKCLEILQIFKYLTK
                     KKLLIFVNSGAYLTKEEVA"
BASE COUNT         2071 a          887 c         1171 g         1842 t
ORIGIN      
        1 gatattttga aaaagaaaaa ttaaagcata ttaaactaat ttcggaggtc attaaaacta
       61 ttagtgaaat catcaaactc attatggatt taatttaaac tttttatttt aggaggcaaa
      121 aatggataag aaatactcaa taggcttaga tatcggcaca aatagcgtcg gatgggcggt
      181 gatcactgat gattataagg ttccgtctaa aaagttcaag gttctgggaa atacagaccg
      241 ccacagtatc aaaaaaaatc ttataggggc tcttttattt gacagtggag agacagcgga
      301 agcgactcgt ctcaaacgga cagctcgtag aaggtataca cgtcggaaga atcgtatttg
      361 ttatctacag gagatttttt caaatgagat ggcgaaagta gatgatagtt tctttcatcg
      421 acttgaagag tcttttttgg tggaagaaga caagaagcat gaacgtcatc ctatttttgg
      481 aaatatagta gatgaagttg cttatcatga gaaatatcca actatctatc atctgcgaaa
      541 aaaattggca gattctactg ataaagcgga tttgcgctta atctatttgg ccttagcgca
      601 tatgattaag tttcgtggtc attttttgat tgagggagat ttaaatcctg ataatagtga
      661 tgtggacaaa ctatttatcc agttggtaca aacctacaat caattatttg aagaaaaccc
      721 tattaacgca agtagagtag atgctaaagc gattctttct gcacgattga gtaaatcaag
      781 acgattagaa aatctcattg ctcagctccc cggtgagaag aaaaatggat tgtttgggaa
      841 tctcattgct ttgtcattgg gattgacccc taattttaaa tcaaattttg atttggcaga
      901 agatgctaaa ttacagcttt caaaagatac ttacgatgat gatttagata atttattggc
      961 gcaaattgga gatcaatatg ctgatttgtt tttggcagct aagaatttat cagatgctac
     1021 tttactttca gatatcctaa gagtaaatag tgaaataact aaggctcccc tatcagcttc
     1081 aatgattaag cgctacgatg aacatcatca agacttgact cttttaaaag ctttagttcg
     1141 acaacaactt ccagaaaagt ataaagaaat cttttttgat caatcaaaaa acggatatgc
     1201 aggttatatt gatgggggag ctagccaaga agaattttat aaatttatca aaccaatttt
     1261 agaaaaaatg gatggtactg aggaattatt ggcgaaacta aatcgtgaag acttgctgcg
     1321 caagcaacgg acctttgaca acggctctat tccccatcaa attcacttgg gtgagctgca
     1381 tgctattctg agaagacaag aagactttta tccattttta aaagacaatc gtgagaagat
     1441 tgaaaaaatc ttgacctttc gaattccata ttatgttggc ccattggcgc gtggaaatag
     1501 tcgctttgca tggatgactc ggaagtctga agaaacgatt actccatgga attttgaaga
     1561 agttgtcgat aaaggtgctt cagctcaatc atttattgaa cgcatgacaa actttgataa
     1621 aaatcttcca aatgaaaaag tactaccaaa acatagtttg ctttatgagt attttacggt
     1681 ttataacgaa ttgacaaagg tcaaatatgt tactgaggga atgcgaaaac cagcatttct
     1741 ttcaggtgaa cagaagaaag ccattgttga tttactcttc aaaacaaatc gaaaagtaac
     1801 cgttaagcaa ttaaaagaag attatttcaa aaaaatagaa tgttttgata gtgttgaaat
     1861 ttcaggcgtt gaagatcggt ttaatgcgtc attaggtacc taccatgatt tgctaaaaat
     1921 tattaaagat aaagattttt tggataatga agaaaatgaa gatatcttag aggatattgt
     1981 tttaacattg actttatttg aagataagga aatgattgag gaacgactta aaacatatgc
     2041 tcacctcttt gatgataagg tgatgaaaca acttaaacgt cgccattata ctggctgggg
     2101 gcgtttgtct cgaaaattga ttaatggtat tagggataag caatctggta aaacaatatt
     2161 agattttttg aaatcagatg gttttgccaa tcgcaatttt atacagctga ttcatgatga
     2221 tagtttaaca ttcaaggaag ctattcaaaa agcacaggtg tctggacaag gccatagttt
     2281 acatgaacag attgctaact tagctggcag tcctgctatt aaaaaaggta ttttacagtc
     2341 tgtaaaagtt gttgatgaac tggtcaaagt aatggggcat aagccagaaa atatcgttat
     2401 tgaaatggca cgtgaaaatc agacaactca aaagggccag aaaaattcgc gagagcgtat
     2461 gaaacgaatc gaagaaggta tcaaagaatt aggaagtcag attcttaaag agcatcctgt
     2521 tgaaaatact caattgcaaa atgaaaagct ctatctctat tatctacaaa atggaagaga
     2581 catgtatgtg gaccaagaat tagatattaa tcgtttaagt gattatgatg tcgatcacat
     2641 tgttccacaa agtttcatta aagacgattc aatagacaat aaggtcttaa cgcgttctga
     2701 taaaaatcgt ggtaaatctg atgacgttcc aagtgaagaa gtagtcaaaa agatgaaaaa
     2761 ctattggaga caacttctaa acgctaagtt aatcactcaa cgtaagtttg ataatttaac
     2821 gaaagctgaa cgtggaggtt tgagtgaact tgataaagct ggttttatca aacgccaatt
     2881 ggttgaaact cgccaaatca ctaagcatgt ggcacaaatt ttggatagtc gcatgaatac
     2941 taaatacgat gaaaatgata aacttattcg agaggttaaa gtgattacct taaaatctaa
     3001 attagtttct gacttccgaa aagatttcca attctataaa gtacgtgaga ttaacaatta
     3061 ccatcatgcc catgatgcgt atctgaatgc cgtcgttgga actgctttga ttaagaaata
     3121 tccaaaacta gaatcggagt ttgtctatgg tgattataaa gtttatgatg ttcgtaaaat
     3181 gattgctaag tctgagcagg aaataggcaa agcaaccgca aaacgtttct tttattctaa
     3241 tatcatgaac tttttcaaaa cagaaattac acttgcaaat ggagagattc gcaaacgccc
     3301 tctaatcgaa actaatgagg aaaccggaga aattgtctgg gataaagggc gagattttgc
     3361 cacagtgcgc aaagtattgt ccatgccaca agtcaatatt gtcaagaaaa cagaagtaca
     3421 gacaggtgca ctgactaatg aatcaattta tgctagagga agttttgata aattaatcag
     3481 tcgtaaacat cgttttgagt cctctaaata tggaggattt ggcagcccga ctgttactta
     3541 tagtgtgtta gtagttgcga aatccaaagt tcaagatgga aaagtaaaaa aaataaaaac
     3601 tggaaaagaa ttaattggga ttacattatt agataaacta gtttttgaaa aaaatccatt
     3661 aaaatttatt gaagataagg gatacggaaa tgttcaaatt gataagtgca ttaagttacc
     3721 taaatatagc ctctttgaat ttgaaaatgg cactcgaaga atgcttgcta gtgttatggc
     3781 gaataataat agcaggggag atttgcaaaa agcaaatgaa atgtttttac cggcgaagtt
     3841 ggtaacactg ctataccatg cacacaaaat tgagagttct aaagaattgg agcatgaagc
     3901 atacattttg gaccactata atgatttata tcaattgctg agctatatag aacgatttgc
     3961 ttcattatac gtggatgttg aaaagaacat ttctaaagta aaagaacttt tcagcaacat
     4021 tgaaagctat tctatttctg aaatttgttc ctccgttatt aatttattaa cacttacagc
     4081 atccggtgct cctgcagatt ttaaattctt aggcacaaca attccacgaa aacgttatgg
     4141 ttctccccag tctattctca gttctaccct tatccatcaa tccatcactg gtctctatga
     4201 gacccgtatt gatttgagtc agctaggaag tgactgatgg ctggttggcg tactgttgtg
     4261 gtaaataccc actcgaaatt atcctataag aataatcatc tgatttttaa ggatgcctat
     4321 aaaacggagc tgatccattt atcagaaatt gatattttgt tattagaaac gaccgatatt
     4381 gtcttgtcca ctatgctggt aaaacggcta gtggatgaga atgtccttgt catattctgt
     4441 gatgataaac gattaccaac agctatgctg atgccttttt atggtcgtca tgattcgagt
     4501 ctacagcttt ggaaacaaat gtcctggcca gaagcagtca aatcggaggt ttggacgacg
     4561 attattgctc aaaagatttt gaatcaatct tgctatctag gagcatgctc ctattttgaa
     4621 aaatcccaat ctattatgga tttatatcat ggtttggaaa attttgatcc gagtaatcga
     4681 gaagggcatg cagcgagaat ttattttaat acactttttg ggaacgattt ctcaagagat
     4741 ttggagcatc caatcaatgc aggtctggat tatggttata ctttattatt gagtatgttt
     4801 gcgcgtgaag tggttgtgtc tggatgtatg actcagtttg agcttaaaca cgctaatcag
     4861 tttaatcagt tcaattttgc tagcgatatt atggaaccat ttaggccttt agtggataag
     4921 attgtttatg aaaatcgaaa tcagcctttt cccaaaataa agagagagtt atttactttc
     4981 ttttcagata cattttcata taatggtaaa gagatgtatc tcacgaatat tattagcgat
     5041 tatactaaaa aagttgtcaa agctctgaat aatgaaggga aaggagttcc tgaatttagg
     5101 atatgagtta tagatatatg agaatgatac ttatgtttga tatgccgacg gacaccgctg
     5161 aggaacgaaa agcctatcga aaatttcgga aatttttact tagtgaaggg tttatcatgc
     5221 atcaattttc tatttatagt aagttgctat tgaataatac agctaacaat gccatgattg
     5281 gtcggctgag ggagcataat cctaataaag gaaatattac tttattaaca gtcacggaaa
     5341 aacagtttgc acgaatgatt tatttacatg gtgaaagaaa taattgtatt gcaaactccg
     5401 atgaaagact tgtatttctt ggggaggctt ttgatgaatc ttaattttcc cttactagat
     5461 gaaccgattc cattaagagg cggtacaatt cttgtgctcg aagatgtctg tgtattttca
     5521 aaaatagtgc aatattgtta ccaatatgag gaagattctg aacttaaatt ttttgatcac
     5581 aagatgaaaa ccatcaaaga atcagaaatc atgcttgtaa cagatatttt aggatttgat
     5641 gttaactcct caaccatttt aaaattgatt catgcagatt tagaatctca atttaatgag
     5701 aaacccgaag tgaaatcgat gattgacaaa ttggttgcta cgattacaga actgattgtc
     5761 tttgaatgct tagaaaatga attagattta gagtatgatg aaattacaat tctggaattg
     5821 attaaatgtt taggagtaaa agtagaaacg caaagtgata ctatttttga aaaatgtcta
     5881 gaaatacttc aaattttcaa atatctcact aagaaaaagt tgctcatttt tgtcaatagt
     5941 ggagcttatc taacaaaaga ggaagtggct a
//
LOCUS       DAUDWO010000062         5487 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.063, whole genome shotgun sequence.
ACCESSION   DAUDWO010000062 DAUDWO010000000
VERSION     DAUDWO010000062.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5487)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5487)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5487
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.063"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..1233
                     /locus_tag="VHC05_001646"
     CDS             <1..1233
                     /locus_tag="VHC05_001646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HEQ5402928.1"
                     /translation="KLENGLTVYFIKKIGFLEKTAMLTVDFGSLDNKLTVDDESRDAP
                     AGIAHFLEHKLFEDESGGDISLKFTQLGAETNAFTTFNQTSFFFSTASKFQENLELLQ
                     YFVLSANITDESVSREKKIIGQEIDMYQDDADYRAYSGILQNLFPKTSLANDIAGSKE
                     SIQKITKILLETHHTYFYQPTNMSLFIVGDIDIDETFLAIQRFQTTLSYPDRKRVTVD
                     PLHYYPVIKSSSVDMDVTTAKLVVGFRGYLTLTQHSLLTYRIALKLFLSMLIGWTSKI
                     YHTLYEDGKIDDSFDVDVEIHHNFQFVLISLDTPEPIAMSNYIRQKLATIKISKEFTN
                     EHLNLLKKEMYGDFIQSLDSIEHLTHQFSLYLSDSDKETYFDIPKIIERLTLKDVVTI
                     GKAFFEKADASDFTVFPK"
     gene            1283..2308
                     /locus_tag="VHC05_001647"
     CDS             1283..2308
                     /locus_tag="VHC05_001647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEQ5402929.1"
                     /translation="MSEKSLGEVLRESRVGKNITLDDIELKTGISSHYLLAMELDQFK
                     IIPEEKFDQFLKEYADIVELDFNTLKRRYRYQVNSKKDSDIKSVTEIVEEKLSKKRLQ
                     EKLLSHQSMGYGQPLEVSKNKETLVIPVKTVGLDSKSPLKTISPVSKFKSDNRLIPKK
                     NVSRMRRNSTDSRSKTSLFPIVILGTIAFAIISVIILGVWQQFEKSQRAKEAEVALLK
                     ASEQSTNGLKNNSNDRKTQVTTEGSGNYLIATVTKSKETVDISVSLTEAQSSWISLTN
                     SEIGEGGITLTQDSPTYTATLPAEITESLLTLGVTNGVSVTIDGQPVDLSPLTSTDLS
                     YITFKIQ"
     gene            2322..2864
                     /gene="pgsA"
                     /locus_tag="VHC05_001648"
     CDS             2322..2864
                     /gene="pgsA"
                     /locus_tag="VHC05_001648"
                     /EC_number="2.7.8.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HEQ5402930.1"
                     /translation="MIKKENIPNLLTLVRIAMIPFFLFITSSSNKVGWHIFAAVIFAI
                     ASFTDYLDGYLARKWHVVSNFGKFADPLADKMLVMSAFIMLVGLGLVPAWVSAVIICR
                     ELAVTGLRLLLVETGGKVLAAAMLGKIKTATQMLSIILLLCHWIFLGNVLLYIALFFT
                     IYSGYDYFKGASFLFKDTFK"
     gene            2866..3705
                     /locus_tag="VHC05_001649"
     CDS             2866..3705
                     /locus_tag="VHC05_001649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HEQ5402931.1"
                     /translation="MSAIIELKKVTFNYHKDQEKPTLDGVSFHVKQGEWLSIIGHNGS
                     GKSTTIRLIDGLLEPESGSIIVDGDLLTITNVWEIRHKIGMVFQNPDNQFVGATVEDD
                     VAFGLENKGIAHEDIKERVNHALELVGMQNFKEKEPARLSGGQKQRVAIAGAVAMKPK
                     IIILDEATSMLDPKGRLELIKTIKNIRDDYQLTVISITHDLDEVALSDRVLVMKDGQV
                     ESTSTPEQLFARGDELLQLGLDIPFTTSVVQMLQEEGYPIDYGYLTEKELENQLCQLI
                     SKM"
     gene            3681..4523
                     /locus_tag="VHC05_001650"
     CDS             3681..4523
                     /locus_tag="VHC05_001650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HEQ5402932.1"
                     /translation="MSINLQNVSYTYQAGTPFEGRALFNINLDILDGSYTAFIGHTGS
                     GKSTIMQLLNGLHVPTTGIVSVDKQDITNHSKNKEIKSIRKHVGLVFQFPESQLFEET
                     VLKDVAFGPQNFGVSPEEAEALAREKLALVGISENLFEKNPFELSGGQMRRVAIAGIL
                     AMQPKVLVLDEPTAGLDPKGRKELMTIFKKLHQSGMTIVLVTHLMDDVANYADFVYVL
                     DKGKIILSGKPKTIFQQVSLLEKKQLGVPKVTKLAQRLVDRGIPISSLPITLEELREV
                     LKHG"
     gene            4516..5316
                     /locus_tag="VHC05_001651"
     CDS             4516..5316
                     /locus_tag="VHC05_001651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEQ5402933.1"
                     /translation="MDKLILGRYIPGDSLIHRLDPRSKLLAMIIYIVIIFWANNVVTN
                     LLMLTFTLAVVFLSKIKLSFFLNGVKPMIGIILFTTLFQMFFSQGGKVIFSWWFISIT
                     DLGLSQAILIFMRFVLIIFFSTLLTLTTTPLSLSDAVESLLKPLTRFKVPAHEIGLML
                     SLSLRFVPTLMDDTTRIMNAQRARGVDFGEGNLIQKVKSIIPILIPLFASSFKRADAL
                     AIAMEARGYQGGEGRTKYRQLDWQLKDSLAIGIVSLLGLLLFFLKTSL"
BASE COUNT         1791 a          866 c         1021 g         1809 t
ORIGIN      
        1 aaattagaaa atggtttaac tgtttatttt ataaaaaaaa tagggttttt agaaaaaaca
       61 gctatgttga cagtagattt cggttctctt gacaataagt tgacagtcga tgacgaatca
      121 cgagatgctc cagcaggtat tgcacacttt ttagaacata aactctttga agatgaatca
      181 ggtggagata tttcattaaa gtttacacaa ctaggagcag agacaaatgc ctttacaact
      241 ttcaaccaaa cgagtttctt cttttcaaca gctagtaaat ttcaggaaaa tttggaactc
      301 cttcaatatt ttgttctttc tgctaatata acagatgaat ctgttagtag agaaaaaaaa
      361 ataatcgggc aagaaattga tatgtatcaa gatgatgctg actaccgtgc atatagtgga
      421 atccttcaga acttatttcc aaaaacaagt ttagctaatg atattgctgg ctcaaaagaa
      481 tccattcaga agatcacgaa aatattattg gaaacgcatc atacttattt ttaccaacct
      541 actaatatga gtctattcat tgtcggtgat attgatattg acgaaacttt tttagctatt
      601 caaaggtttc aaaccacatt atcctatcca gatagaaaaa gggtaactgt tgatccttta
      661 cactactatc ctgttattaa atcatcttct gttgacatgg atgttactac tgctaagctg
      721 gttgttggtt ttcgagggta tctgacctta actcagcatt cactattaac gtatcgtatt
      781 gccttgaagc tatttttatc aatgcttata ggttggactt ctaaaatcta tcatacgcta
      841 tatgaagatg gtaaaataga cgattcattt gatgtggatg ttgaaattca tcataatttt
      901 caatttgtat taatatcact tgatacacca gagcctatcg caatgtctaa ctatatccgt
      961 caaaaattag ccactataaa gatatcaaaa gagtttacaa atgagcactt aaatctatta
     1021 aaaaaagaaa tgtatggtga ctttattcag agtttagact ctatagaaca tttaacccat
     1081 cagttcagtc tatacctgtc tgattctgat aaagaaacat attttgatat tccaaaaatt
     1141 atagaaagac tcactctaaa agatgttgtt acaattggaa aagcattttt tgaaaaagct
     1201 gatgcttcag acttcacagt cttcccaaaa tagatgaaaa tctgttataa tagggttact
     1261 atattatttt tgaggtacct gtatgagtga aaaaagtctt ggtgaagtgt taagagaatc
     1321 gcgtgttgga aaaaatatca cactagatga tatagaattg aagacaggga tttcttccca
     1381 ttacttgctg gcaatggaat tggatcagtt taaaattatt ccggaagaaa aatttgatca
     1441 atttttaaaa gaatatgctg acattgttga gttagatttc aatactttaa aaagacgata
     1501 ccgttatcaa gttaattcca aaaaagacag tgatataaaa tctgtaactg agattgttga
     1561 agagaagtta agtaagaaac gattacaaga gaagttgtta tcacatcaga gcatggggta
     1621 tggtcaaccg ttagaagttt ctaaaaacaa agaaacctta gttatccctg taaagactgt
     1681 tggtttagat agcaaatcgc cactaaaaac gatatcgcct gttagcaaat ttaaatcaga
     1741 taacaggtta attcctaaaa aaaatgtgtc acgtatgagg cgaaatagca ctgacagtcg
     1801 ttctaaaacg tcactatttc ctatagttat attaggaacg attgcttttg caattatcag
     1861 tgttatcatt ttaggtgttt ggcaacaatt cgaaaagagt caaagagcta aagaagctga
     1921 agttgctttg cttaaagcct ctgagcagtc tactaacggt ttaaaaaata attcaaatga
     1981 tcgcaaaact caagtcacaa ctgaggggtc ggggaattat ttaatagcga ctgttactaa
     2041 atctaaagag accgttgata tcagtgtgtc tttaaccgag gcacaaagta gttggatttc
     2101 tctaacaaat tcagaaattg gtgaaggtgg tataacattg actcaagact cgccaactta
     2161 tacagcgact ttacctgcag aaataacaga atcattgttg acgcttggtg tgacaaatgg
     2221 tgtatctgta acaattgatg gacaacctgt tgatctatca cctttaacaa gtactgactt
     2281 aagttatatc acgtttaaga tccaataatt aaggtagact aatgataaaa aaagaaaata
     2341 ttcctaatct attaactctt gttcgaatcg caatgattcc tttctttctt tttattactt
     2401 cctcatctaa taaggtgggg tggcatattt ttgcagctgt gatttttgca attgccagtt
     2461 ttaccgatta tctagatggg tatcttgcgc gtaagtggca tgtagtcagt aattttggaa
     2521 agtttgccga tcctctagca gataagatgc ttgtcatgag tgcctttatc atgttagttg
     2581 gacttggctt agttcctgcg tgggtatcag ctgttattat ttgccgagaa ttggcagtaa
     2641 ctggtcttcg attactactt gttgaaaccg gaggaaaggt ccttgcagct gctatgctgg
     2701 gaaaaatcaa aacagcgaca caaatgttgt ctattatttt attactttgc cattggatat
     2761 tcctaggaaa cgtcttactc tatattgctc tttttttcac tatttattct ggatatgatt
     2821 attttaaagg agcaagcttt ctttttaagg atacgtttaa ataacatgtc agctattatt
     2881 gaacttaaaa aagttacatt taattaccat aaagaccaag aaaaaccaac attagatggc
     2941 gtatcgtttc atgtgaaaca aggtgagtgg ctgtctatca ttggccataa cggatctggt
     3001 aaatcaacga ctattcggtt aattgatgga ttattggaac cagaatcagg gtctattatt
     3061 gttgatggag atctactaac cataactaat gtttgggaaa ttcgtcataa aattggtatg
     3121 gtctttcaaa accctgataa tcagtttgtt ggagcaactg ttgaagatga tgttgctttt
     3181 gggcttgaaa ataaaggtat tgcacatgaa gatataaaag agagggttaa tcatgcttta
     3241 gagttagtcg gcatgcagaa ctttaaagaa aaagaaccag cccgtttatc tggtggccaa
     3301 aaacagcgcg tagctattgc aggtgcagtt gctatgaagc ctaaaattat tattttagat
     3361 gaagctacta gtatgcttga ccctaaagga cgattagagt taattaaaac tataaaaaac
     3421 atccgtgacg actaccagct gactgttatt tccattactc atgacttaga tgaagttgct
     3481 cttagtgata gagttttagt gatgaaagat ggtcaagtgg aatcaacatc aacaccagaa
     3541 caattatttg caagagggga tgaactactc caattaggtc ttgatatccc ttttacaaca
     3601 tctgttgtac agatgcttca agaagaaggt tatcctattg actatggata tctcacagaa
     3661 aaggaattag aaaatcagtt atgtcaatta atctccaaaa tgtaagttat acttatcaag
     3721 cagggactcc ttttgaaggg cgtgcccttt ttaacattaa tttagatatt ttagatggtt
     3781 cttatacggc ttttatcgga catactggat ccgggaaatc gactattatg caattgctaa
     3841 atggtttaca cgttccgaca acgggaattg tcagcgtaga taaacaagat ataacgaatc
     3901 actctaaaaa taaagagatt aaatctattc gaaaacatgt aggattagtt tttcaatttc
     3961 cagaaagtca actatttgaa gagacagttt tgaaagatgt tgcttttggc cctcaaaatt
     4021 ttggggtctc tccggaggaa gcagaagctt tagcgcgtga aaaactagct cttgttggga
     4081 tttcagaaaa tctttttgaa aagaatccat ttgaactctc agggggtcaa atgcgtcgtg
     4141 ttgctattgc gggtatcctt gctatgcagc caaaggtttt agttttagat gaaccgactg
     4201 ctggtcttga tcctaaaggg cgtaaagaat taatgactat ttttaaaaag ttacaccaat
     4261 ctggcatgac tattgtttta gtaacccatc tgatggatga tgtggccaat tacgcagatt
     4321 ttgtatatgt tcttgacaaa ggtaaaatta ttttatcagg aaaaccaaaa acaatttttc
     4381 aacaagtcag tttgcttgag aaaaaacagt taggagttcc taaggtgact aaacttgctc
     4441 aaaggcttgt tgatagagga atacctatct cttctttgcc tattacctta gaggagctaa
     4501 gagaggtact aaaacatgga taagctgatt cttggtcgtt atattcccgg agattctctc
     4561 attcatcgtc ttgacccaag aagtaaatta ttagcgatga ttatttatat tgtcattatc
     4621 ttttgggcta acaatgttgt gacaaatttg ttgatgttga cttttacttt agcagttgtt
     4681 tttttgtcaa aaatcaagtt gtctttcttt ttaaatgggg ttaaaccaat gattggtatt
     4741 atcctcttca cgactttatt tcagatgttt ttctcacaag gaggaaaagt aatttttagt
     4801 tggtggttca ttagcataac tgatttagga ttgagccaag ctattttaat ttttatgcgt
     4861 ttcgttctaa ttattttctt ttcaacgctg ttaacgttga cgacaacacc tttaagccta
     4921 tctgatgcag ttgaatcatt attaaaacct ttaacaagat ttaaagttcc agctcacgag
     4981 atcggactaa tgctttcttt aagtttacgt tttgtgccta ctttaatgga tgataccacg
     5041 cgtattatga atgcacaaag ggcccgtgga gttgattttg gagagggaaa tttaattcaa
     5101 aaagttaaat ccattattcc tattttaatc cctcttttcg cttcaagctt taaaagagcc
     5161 gacgcattag ctattgctat ggaagctaga ggttatcagg gaggagaagg gcgaactaaa
     5221 tatcgtcaat tagactggca gctaaaagat agtttagcta ttggaatagt ttctttattg
     5281 ggtttgctac tttttttctt gaaaacctct ttgtaatatt ttttagcaca aaacttttct
     5341 ttattataag aagtgaattg tacctcaaaa gttagataca acatctaatg attgaggtac
     5401 ttttcttcat ttgaggaatt gaaaaccgct atctcaacta tattaatcat cccaacaata
     5461 acaaatcgaa cgaaatctaa aaggact
//
LOCUS       DAUDWO010000063         5311 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.064, whole genome shotgun sequence.
ACCESSION   DAUDWO010000063 DAUDWO010000000
VERSION     DAUDWO010000063.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5311)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5311)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5311
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.064"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..1016
                     /locus_tag="VHC05_001652"
     CDS             <1..1016
                     /locus_tag="VHC05_001652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402934.1"
                     /translation="IAIQSIIMFLAVREAFLGILLVGNVTTFIRSLSTMQTSTQNIVN
                     NIYSFYNGSLYIELLYDFTHDELVHNPIIESTVDTIQSVEFERVSFSYNGKDNVINDI
                     SFSIKAGERLAIVGENGSGKSTIFKLACGLYDNYEGNIYINGINLRSIQKKSYYKRIS
                     ALFQDFLKYELTLRENVGLGELSKLYSDEDLISALKYTGVDSIFYFNQEKLNQIDLEQ
                     QLGNWFEDGRQLSGGQWQKIALSRVYLKEADCYLLDEPSSALDPESETKIFKTFFELS
                     QNKIGIFITHKPSITQSVNKILYLDNGCISETGSFADLNIKGMKFKNLLDKEIGATYD
                     TSN"
     gene            1000..2244
                     /locus_tag="VHC05_001653"
     CDS             1000..2244
                     /locus_tag="VHC05_001653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lanthionine synthetase C family protein"
                     /protein_id="HEQ5402935.1"
                     /translation="MTPQIKQIVDYIADSFINYEQIVAESENKVLINIESKYRNTFFD
                     KSLSHGVPSLILMYSSLYKVTKDERYLTFSNIYVEKLVDIISRDGIESPSLYAGTAGI
                     ALAIKEASISGKYYPKLLSSLNCLLKEQIKDKLVVSFSNIEKGIIEPYDYDMVNGFSG
                     ITNYLLLEQEFFSVELNQIGNYLLKYIETILNKVTNCSEDREAEFDLGIAHGITGPML
                     ILAKLKSEKILSVEVGDILNKAINLMFLFRRDDKLWPGKIYTSNILDLDLNYLPTRMA
                     WCYGTPGTAVALFKMCQLIDLNFIDDINESLIAQMRSSDKNVYSLTMCHGLAGVTFIY
                     DLIGKNYSSERLTRFAEELRQQIITSFSTTKVFGYTDREKFGEIEVELESIGILQGVS
                     GIVLFLLNPYSDEELLWQRIFI"
     gene            2263..4634
                     /locus_tag="VHC05_001654"
                     /pseudo
     CDS             2263..4634
                     /locus_tag="VHC05_001654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528611.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
     gene            4640..>5311
                     /locus_tag="VHC05_001655"
     CDS             4640..>5311
                     /locus_tag="VHC05_001655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="HEQ5402936.1"
                     /translation="MLKIQNLKKSYGKRTILNNVNMNIPKGKVYALIGPNGAGKSTIM
                     KILTGLVSKTSGSIIFEGREWSRRDLRKIGSIIEEPPLYKNLSAYDNMKVVTTMLGVS
                     ESTILPLLNKVGLGNIDKRPVKQFSLGMKQRLGIAISLINSPKLLILDEPTNGLDPIG
                     IQELREIIESFKSEGMTIMISSHILSEVEHLADFIGFIYEGKIILEKEYDGSENLEEL
                     FNNQIL"
BASE COUNT         1984 a          619 c          971 g         1737 t
ORIGIN      
        1 agattgctat acaatctatt attatgttcc ttgcagttag agaagcattt ctaggaatat
       61 tattagttgg aaatgtaact acttttataa ggtctttatc tacaatgcaa acaagtacac
      121 aaaatatagt aaataatatc tattctttct ataatggttc attgtacata gagttattgt
      181 atgattttac gcatgatgag ttagtacata accctataat cgaaagtacg gttgatacaa
      241 ttcagtcagt tgaatttgaa agagtttctt tttcatataa tggtaaggat aatgtaataa
      301 acgatataag tttttcaatt aaagcaggag agaggttagc aattgttggt gaaaatggtt
      361 ctggaaaaag tacgattttc aaattagcct gcggtcttta cgataattat gaaggcaata
      421 tatatataaa tggtattaat cttcgttcaa tacagaaaaa gtcatactac aagagaatat
      481 ccgcattgtt ccaagatttt ttaaagtatg aattgacact gcgtgaaaat gttggattgg
      541 gtgaattatc aaagttatat agtgatgagg atttaataag tgcactgaag tatacaggag
      601 ttgattcgat attttacttt aatcaggaaa aattaaatca gatagatctg gaacagcaat
      661 tagggaattg gtttgaggat gggagacagt tatctggtgg acagtggcaa aaaatcgcat
      721 tatcaagagt atatctcaaa gaagcggatt gctatttgct agatgagcct agttctgcgt
      781 tagatcctga gtctgaaaca aaaattttta aaacattttt tgaattatcg caaaataaaa
      841 ttggtatttt tattacgcat aagccaagca ttactcaatc tgtgaataaa attttgtatc
      901 tagataatgg atgtatatct gaaacaggaa gtttcgctga tttaaatatt aaaggaatga
      961 agtttaaaaa cttattagat aaagaaattg gagccacata tgacacctca aattaaacag
     1021 atagtagatt acattgcaga tagttttata aattatgaac agatagtagc tgaaagtgag
     1081 aataaagtac taattaatat tgaatctaaa tatagaaata ccttttttga taaatctctg
     1141 agtcatggtg tgccatcatt aatcttaatg tatagttcac tatataaagt gacaaaagat
     1201 gagagatatc taacattctc caacatatac gttgagaaat tagtagacat aatctctaga
     1261 gatggtatag aatctccgtc tctctatgct ggcactgcag gtattgcatt agctattaaa
     1321 gaagcgagta tatctggaaa gtattatccg aaattattat catccttaaa ttgtcttcta
     1381 aaagaacaaa ttaaagacaa attggtagta agtttttcta atattgagaa aggaattatt
     1441 gagccatatg attatgatat ggttaacgga tttagtggaa taactaatta cttactcctt
     1501 gaacaagaat ttttttctgt agagttaaat caaattggaa attatctttt gaaatatatt
     1561 gagacaattt taaataaggt aactaattgt tctgaagata gagaagctga atttgatcta
     1621 ggaattgcac atggaattac tggtcctatg ctaatcctag caaaattaaa atcagaaaaa
     1681 attttgagtg tagaagtagg agatatactg aataaagcta taaatttaat gtttttattt
     1741 agaagggatg acaaactatg gcctggaaaa atttatacta gtaatatttt ggatcttgat
     1801 ttaaattatc ttcctactag aatggcatgg tgttacggta cgcctggaac tgcagttgcc
     1861 ctttttaaaa tgtgtcaatt gatagattta aattttattg acgatattaa tgaaagttta
     1921 attgctcaga tgagaagttc agacaaaaat gtctattctc ttacaatgtg ccatggtttg
     1981 gcaggagtaa cttttatata tgacttgatt ggtaaaaatt attcaagtga gaggctaact
     2041 cgctttgcag aagagcttcg ccaacaaata attacatcgt tttcaactac aaaagtattt
     2101 gggtatactg acagagaaaa atttggagaa atagaagttg aactggagtc aatagggata
     2161 ttgcaagggg tatcagggat agtgttattc ttattaaatc cttacagtga cgaggagcta
     2221 ttgtggcaaa gaatatttat ttaatttgaa aaggagaaca aaatgtataa ggtatttcca
     2281 actggtatga ttcgtattcc attgcaaaaa caagaatttt ataataaaga ctatgaagat
     2341 ttaataaatg ataaagtttt tatggaacaa cttttagttg ctagtcccag tctttatgat
     2401 agtgtaatag attttgataa atgtaatgaa aagaaaaagc aaaatgtaaa agtctcatta
     2461 aatagttatt ctaaaagagc agcgtttaga actactccat ttggtatctt tactgctatt
     2521 aatacagttg atttgacaaa gggaaccact tctaatgtac aaaaggttag ttttattaaa
     2581 aaagcagtcc cagattattc atggatatat tctctagtaa aatcgtatga aataagtaac
     2641 cttgaaaaac tttcattaaa aataaataca gcggcgttta ctcaaggtga cagatatgta
     2701 ctaccattta cagtgaatga atcagaggaa gatagaaaca taagtttttc aaaaccaatt
     2761 aagttacttg tagaaaaatg taaaactcga tatataaaat atgaagagtt aatagatgta
     2821 tttaaaaata attatccaga tatagtgtca gacatgctag agtcatatat acacgactta
     2881 gttacaaatg attttttaat ttcagattta agaccaccaa tttgtaatat caattcctta
     2941 gattatctac tatctaaatt agaagaagga acactatgta ctgacttaac tactttaaag
     3001 aagatgattg aagattacaa cgatttaaat attggggaag gtagagactt acttttgcag
     3061 atttttgata aaatggaaag tatttataaa tatgataacg gtggaaatta cttaaaagtt
     3121 gattcattag cagagtatga aggcgatttt aatattctat ctgaaacggc tcgggaaagt
     3181 atagaacgac tcgcagagat gtttgtaaaa ttaaatacaa atgtaaagag aagagggggg
     3241 aggaaaaatt cacttgaaga gtatcagttg aaatttattg gcaaatatgg agaaaactgc
     3301 tcaattccct ttgttgaagt aataaataaa gatgcaggca taggttttcc tgaatattac
     3361 aaaggaggag aaggtgaagc aatagagtta agcgatccaa taatgcaaat gtttgaaaag
     3421 aaatatgagg aagctctatt aaatggaggg catatcgaat tttattcaaa agatttagat
     3481 gattttcaaa cagatcaaag caatagttta gattcgtttg aattaaattt taatataaaa
     3541 ataataaata atgatgtgaa gttatattta ggagctaata tcggttctgg acaagcaggt
     3601 agaagctttg gaagattcta tggattaagc gaaacagtaa gagaaacaat taagaattta
     3661 aaccatcaaa ataatacgaa tgtagagttg tcatttgttc ctaaacagat aagacttgcg
     3721 aatgtaattc aaaattatag tgatgagtct tataatactt cattttttac cacatcatgg
     3781 gattcagaga acgaactgcg attggaggat atttatataa gatatagtga tggtaagttt
     3841 cattttacaa ctatcgatgg gaaaaatgag ttgaaattta ccatgaataa tatgctaaat
     3901 tccgatagcc aaagcagggt tttgagattg ttggttgatt taacatgttt tatatgagat
     3961 ataatgatac caatgatcat ataagaattc ggataaattg tgattcgatt gaaaataact
     4021 tttctttgta tttgtcagta gttcaagatc tattacctca actgattgag agttgtatta
     4081 tctctgacat agaagtgagt agctataaac cagaagtaaa tagatataga ggacctcatt
     4141 taataagtta tgcagaggaa attttttgta aagaatctat cttatttctt aataatacaa
     4201 tagaattttc agatgatgaa agattagttt gtgctactta cttggttcta tattatctaa
     4261 atcacttttt caaagataaa gaaacaaggc gctctttctt atttgagaat tataccggaa
     4321 agtataagaa agatttcaaa aatttgccaa ttgatttacc tattgagtat atgaagattt
     4381 tgaatggagt cacctcagct cttgatagat atgatttttt ccaagaaatg gatagatatc
     4441 ccatgtctta tatgaaagag tataatcgat ttggtggtac aaatgatatc tataatacta
     4501 aattcaattt agtaggaagt tttttacatc tatcaatgaa tcgattaaac gggattgata
     4561 gagagtttga agagaaagtg tattgttttg cttactatac actaaacgct cagcaatata
     4621 tagaatggga gtaactaata tgttgaaaat acaaaatcta aaaaaatctt atggtaagag
     4681 aaccatattg aataatgtca atatgaatat tcctaaggga aaagtgtatg ctttaatcgg
     4741 tccaaatggt gctggaaaat caactattat gaaaattttg acaggcttag ttagtaagac
     4801 aagtggttct attatttttg aaggtagaga atggtcacgt cgggatctgc gaaaaatcgg
     4861 gagtattatt gaagaaccac cactttataa aaatttgagt gcttacgata atatgaaggt
     4921 agttacaaca atgcttggtg tttcagaaag cactatactt ccattattaa ataaagttgg
     4981 tctaggaaat attgacaaga gaccagtaaa acaattttct cttggaatga agcaacggtt
     5041 aggtatagct atctctttaa taaattcacc taaactactt atattagacg aacctactaa
     5101 tggcttggac ccaattggaa ttcaagaatt aagggaaatt atagagtcat ttaaatcaga
     5161 aggaatgaca attatgattt caagccatat actgtcagaa gttgaacatc tagctgattt
     5221 tattggattt atctatgaag gaaagattat tctggaaaaa gaatatgacg gctctgagaa
     5281 tcttgaagag ttattcaata atcaaatttt a
//
LOCUS       DAUDWO010000064         5025 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.065, whole genome shotgun sequence.
ACCESSION   DAUDWO010000064 DAUDWO010000000
VERSION     DAUDWO010000064.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5025)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5025)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5025
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.065"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..674
                     /locus_tag="VHC05_001656"
     CDS             <1..674
                     /locus_tag="VHC05_001656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="alpha-L-Rha alpha-1,3-L-rhamnosyltransferase"
                     /protein_id="HEQ5402937.1"
                     /translation="KLSQYDYIGHFHTKKSKEADFWAGESWRKELIDMLVKPADSILS
                     VFETDDIGIIIADIPSFFRFNKIVNAWNEHLIAQEMMSLWRKMDVKKQIDFQAMDTFV
                     MSYGTFVWFKYDALKSLFDLELTQNDIPSEPLPQNSILHAIERLFVYIAWGNSYDFRI
                     VKNPYELTPFIDNKLLNLREDEGAHTYVNFNQMGGIKGALKYIIVGPAKAMKYIFLRL
                     MEKLK"
     gene            671..3145
                     /locus_tag="VHC05_001657"
     CDS             671..3145
                     /locus_tag="VHC05_001657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfatase-like hydrolase/transferase"
                     /protein_id="HEQ5402938.1"
                     /translation="MIKDTFLKTNWLNISHHITLLVFGFYFSFYSLAKELVSSTAQPV
                     NYYTHLLNVSFVGYIISLIGLSYYLSRQVSRQLFLKTSFIVISYLIVSYWVQITQHLN
                     DKRFDIWSLTKNQFYQFQALPSLLIILVMATLIKILVAYFAIEKDRFGLLGYQGNTFS
                     VALILAVVPISDIHLLKLISSRFSELVRAGNSQIALLKISGLLIVLLVIFATIIYVVL
                     NALKHLKSNKPSFSVAATTSLFLALVFNYTFQYGVKGDEALLGYYVFPGATLFQIVAI
                     TLVALLAYVITNRYWPTTFFLLILGTIISVVNDLKESMRSEPLLVTDFVWLQELGLVT
                     SFVKKSVIVEMVVGLAICIVVAWYLHGRVLAGKLFMSPVKRASAVLGLVIVSCSMLIP
                     FSYEKEGKILSGLPIISALNNDNDINWLGFSTNARYKSLAYVWTRQVTKKIMEKPTNY
                     SQETIASIAQKYQKLAEDINKDRKNNIADQTVIYLLSESLSDPDRVSNVTVSHDVLPN
                     IKAIKNSTTAGLMQSDSYGGGTANMEFQTLTSLPFYNFSSSVSVLYSEVFPKMAKPHT
                     ISEFYQGKNRIAMHPASANNFNRKTVYSNLGFSKFLALSGSKDKFKNIENVGLLTSDK
                     TVYNNILSLINPSESQFFSVITMQNHIPWSSDYPEEIVAEGKNFTEEENHNLTSYARL
                     LSFTDKETRAFLEKLTQINKPITVVFYGDHLPGLYPDSAFNKHIENKYLTDYFIWSNG
                     TNERKNHPLINSSDFTAALFEHTDSKVSPYYALLTEVLNKASVDKSPDSPEVKAIQND
                     LKNIQYDVTIGKGYLLKHKTFFKISR"
     gene            3324..4019
                     /locus_tag="VHC05_001658"
     CDS             3324..4019
                     /locus_tag="VHC05_001658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEQ5402939.1"
                     /translation="MKKLIIIPAYNESSNIVNTIRTIESDAPDFDYIIIDDCSTDNTL
                     AICQKQGFNVISLPINLGIGGAVQTGYHYAQRCGYDVAVQVDGDGQHNPCYLEKMVEV
                     LVQSSVNMVIGSRFITKEGFQSSFARRIGIKYFTWLIALLTGKKITDATSGLRLIDRS
                     LIERFANHYPDDYPEPETVVDVLVSHFKVKEIPVVMNERQGGVSSISLTKSVYYMIKV
                     TLAILVVRLKGNR"
     gene            4021..4362
                     /locus_tag="VHC05_001659"
     CDS             4021..4362
                     /locus_tag="VHC05_001659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2304 domain-containing protein"
                     /protein_id="HEQ5402940.1"
                     /translation="MTVTASLFISFIVLTFVFFLINLIKKDKLAIKYSLLWFILALLI
                     LLFTWLPNILNKMSHFLGIHSPTNMLFFLGFCLSLAIIFSLTNNISLQNDKVKRLTQE
                     VALMKKEKTND"
     gene            4355..>5025
                     /locus_tag="VHC05_001660"
     CDS             4355..>5025
                     /locus_tag="VHC05_001660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligosaccharide flippase family protein"
                     /protein_id="HEQ5402941.1"
                     /translation="MINPSKQNQTIFLWNMLGSLSTAVISVILLMVVTRLLTSSDSDI
                     YAFAYSFANMMVVVGLFQVRNYQATDINEKYSFSQYLVARLMTCLLMLAITVIYLTLT
                     KTDSYKSTIVFLVCFYRSTDAFSDLYQGMFQQHERLDIAGKSLAYRNTLIFMVYTAII
                     LYSKNLTLALVAACIVSLVFIMYYDIGHSKKFQKLMFSELLSNISFQNSLKLLKESFP
                     LFLNG"
BASE COUNT         1658 a          725 c          877 g         1765 t
ORIGIN      
        1 ataaactttc tcaatatgat tatattggtc atttccatac gaaaaaatca aaagaagctg
       61 atttttgggc aggagaatct tggcgaaaag aattgattga tatgctcgtg aaaccagcag
      121 atagtattct tagcgttttt gagacagatg atattggtat tataatcgca gatattccaa
      181 gtttttttag atttaataag attgtcaatg cttggaatga gcatttaatc gctcaagaaa
      241 tgatgtcttt gtggagaaaa atggatgtta aaaaacaaat tgattttcaa gctatggata
      301 catttgttat gagttatgga acatttgtat ggtttaaata cgatgctcta aaatcacttt
      361 ttgatttaga attaactcaa aatgatattc caagtgaacc tttaccacaa aactctatat
      421 tacatgcgat tgagcggtta tttgtctata tagcgtgggg gaattcttat gattttagga
      481 ttgttaaaaa tccctatgag ttaacacctt ttattgacaa taaactgtta aatttacgtg
      541 aagatgaagg agctcatacc tacgttaact ttaatcaaat gggcggtatc aaaggagcat
      601 taaaatatat tatcgttggt cccgctaaag caatgaagta tatattcttg cgtttaatgg
      661 agaaacttaa atgattaaag acacattttt aaaaaccaat tggttaaata ttagtcacca
      721 tattaccctt cttgttttcg gtttttattt cagtttttat agtttggcga aagaactagt
      781 aagctccacg gcacaaccgg taaactatta tactcattta ctaaatgttt cttttgtggg
      841 atatattata tcactgattg gattatctta ttatttgagt cgccaagtta gtcgacagtt
      901 gtttttgaaa actagtttta ttgtgatatc ttatctaatt gtcagctatt gggtacaaat
      961 aacacagcac ctgaatgata aacggtttga tatctggtca ttaactaaaa atcaatttta
     1021 tcaatttcaa gctctacctt ctttactcat tattttagtg atggccactt taataaaaat
     1081 attggtagca tattttgcaa tagaaaaaga tagatttggg ctattaggct atcaaggtaa
     1141 tactttttct gtagctctga ttttagcagt tgtgccaatt agtgacatac atctgttaaa
     1201 actaataagt tctcgatttt ctgaattagt aagagcaggt aatagccaaa ttgcactgtt
     1261 aaaaataagt ggactgttga tagttttact tgtcatattt gcaacaatca tatacgtggt
     1321 tttaaatgct ctaaaacacc ttaagtcaaa taaaccttca ttttcagtag cagctactac
     1381 tagtttgttt ttagcattag tttttaacta tacgttccag tatggagtaa aaggtgatga
     1441 agcattgcta ggatattatg ttttccctgg agctactctt tttcagatag tagctattac
     1501 actagttgct cttttagcat acgtgataac gaatagatat tggccaacta ccttcttttt
     1561 gcttattctg ggaacaatta tttctgttgt taatgattta aaagaatcaa tgagaagcga
     1621 gccgttatta gtaactgatt ttgtttggtt acaagaatta ggtttagtga caagctttgt
     1681 taaaaaatcg gtgattgtag aaatggttgt aggacttgct atttgtattg tggtggcttg
     1741 gtatctacat ggccgagttt tagcagggaa attatttatg agccctgtca aacgggcaag
     1801 tgctgtatta ggtttagtta ttgtatcctg tagtatgtta ataccatttt cttatgaaaa
     1861 agaaggtaaa atattatctg gtcttccgat tatttcggct ttaaataatg ataatgatat
     1921 aaactggtta ggtttttcaa caaatgctag gtacaaatct ttagcatatg tttggacaag
     1981 acaggtgacc aagaaaataa tggaaaaacc gacaaattat agccaagaaa caatagcgag
     2041 tatcgctcag aagtaccaaa aattagcaga agatattaat aaagacagaa aaaataatat
     2101 tgctgaccaa acggttattt atcttttaag tgaaagtttg tcagatcctg atagagtatc
     2161 aaatgttact gttagccacg atgttttacc taatatcaag gcaatcaaaa atagcacaac
     2221 tgctggactc atgcagtcag actcctacgg gggtggaact gctaacatgg agtttcaaac
     2281 gttaacaagc ttaccttttt ataatttttc ttcttcagta tctgttcttt attcagaagt
     2341 ctttcctaaa atggccaaac ctcatacgat tagtgagttt taccaaggaa aaaatcgtat
     2401 tgcgatgcat cctgctagtg ctaacaattt taatagaaaa acagtttata gtaatttagg
     2461 tttttccaaa ttcttagctc tatcgggttc taaggataag tttaagaaca ttgaaaatgt
     2521 cggtttattg actagcgata aaactgtcta taataatatt ttatctttaa ttaatcctag
     2581 tgaaagccaa tttttctcag ttattacaat gcaaaatcat attccttggt catccgatta
     2641 tcctgaagaa attgttgctg aaggaaaaaa tttcacggaa gaagaaaatc acaacctaac
     2701 aagttatgct cggttattat cgtttactga taaggaaaca agagcatttt tagaaaaatt
     2761 aacacaaatt aacaagccta tcacagtggt gttttacgga gatcatttac ccggtttata
     2821 tcctgatagt gcttttaaca agcatattga aaataaatac cttactgatt attttatttg
     2881 gagtaatggt actaacgaga gaaaaaatca tccgcttatc aactcaagtg attttactgc
     2941 agctttattt gagcatactg attcaaaagt atcaccttac tatgctttgt taacagaggt
     3001 actgaataaa gctagtgtcg ataaatcacc agatagtcct gaagttaaag ctattcagaa
     3061 tgatttaaaa aatatccaat acgatgtgac tataggaaaa ggttaccttt tgaaacacaa
     3121 aacttttttt aagatatcac gttaagaaaa atgctaggct gtccgagtat agacgagcat
     3181 caaggtttgg taatttgctc aaatgattgt caacagagtg tctaggacca ggtttaaaag
     3241 attataattc ttaaggtctt attcgtttat aaaaaatgaa tactctttta aaatcttaat
     3301 tgaaatgaat aggagaagtt ttcgtgaaaa agttaatcat tattcctgct tacaatgaaa
     3361 gcagtaatat tgtcaatact atacgtacta ttgaatcaga tgccccggat tttgactata
     3421 tcattattga tgattgctca acggataata cgttagcaat atgtcaaaaa caggggttca
     3481 atgttatttc tttgcccatt aacctgggaa ttggcggtgc ggtgcaaact ggctatcatt
     3541 atgcacaaag atgtggatat gacgttgcag ttcaagtaga tggagatggt cagcacaatc
     3601 catgctattt ggaaaaaatg gttgaggtat tagttcaatc ttcagtaaat atggtaattg
     3661 gatcacgatt tatcacaaaa gaagggtttc agtcatcatt tgctcgacgt atcggtataa
     3721 agtattttac ttggcttatt gcgctactaa caggaaaaaa aataacagat gcaacgtcag
     3781 gtctaaggtt aattgaccgt tcattgattg aacgttttgc taatcattat ccagatgatt
     3841 atcctgaacc tgaaacagtt gttgatgtat tggttagtca ttttaaagtg aaagaaattc
     3901 ctgttgtaat gaatgagcga caaggcggtg tgtcatctat ctcgttgacg aaatcggtct
     3961 attatatgat taaagtgact ttagctattt tagttgttag attgaaagga aatcgttaaa
     4021 atgacggtaa cagccagttt atttataagt tttattgtat taacctttgt tttctttttg
     4081 attaacttaa tcaaaaaaga caaactagcg attaagtact ctttattgtg gtttatttta
     4141 gctttattaa ttttactatt tacgtggtta cctaacatat taaataaaat gtctcacttc
     4201 ctgggtattc attcaccaac caatatgtta ttctttttag gtttttgttt gagtttagct
     4261 attatttttt cactgactaa taatatttca cttcaaaatg ataaagtaaa acgtctgacc
     4321 caagaagtgg cccttatgaa aaaagagaaa accaatgatt aatccttcaa aacaaaacca
     4381 aacgattttt ttatggaata tgttaggaag tttatcaaca gctgtaatat cagttatatt
     4441 acttatggtg gttactaggt tactaacttc gtctgattca gatatttacg cctttgccta
     4501 ttcttttgct aatatgatgg tagttgttgg actttttcag gttcgtaatt atcaagcaac
     4561 agatattaat gaaaaatatt cctttagtca gtacttagtg gcaagactga tgacttgttt
     4621 attaatgtta gccataacag taatttattt aacgttaact aagacagata gctacaagag
     4681 tacaattgtc tttctagtct gtttctatag atcgacagat gctttttcgg atttatatca
     4741 gggaatgttc caacaacatg aacggctgga tattgcaggt aaatcgctag cctacagaaa
     4801 tactcttatt tttatggtgt acacagcaat aatattatat tccaaaaatc ttactttagc
     4861 attagtagct gcctgtatag tttcattagt ttttataatg tattatgaca ttggccattc
     4921 gaaaaaattt caaaagttga tgtttagtga attattaagt aatatttcat ttcaaaacag
     4981 tttaaagtta ttaaaagaaa gttttccact ttttctaaac ggttt
//
LOCUS       DAUDWO010000065         4859 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.066, whole genome shotgun sequence.
ACCESSION   DAUDWO010000065 DAUDWO010000000
VERSION     DAUDWO010000065.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4859)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4859)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4859
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.066"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            67..1615
                     /locus_tag="VHC05_001661"
     rRNA            67..1615
                     /locus_tag="VHC05_001661"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
     gene            1667..1739
                     /locus_tag="VHC05_001662"
     tRNA            1667..1739
                     /locus_tag="VHC05_001662"
                     /product="tRNA-Ala"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1700..1702,aa:Ala,seq:tgc)
     gene            2038..>4859
                     /locus_tag="VHC05_001663"
     rRNA            2038..>4859
                     /locus_tag="VHC05_001663"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT         1367 a         1011 c         1407 g         1074 t
ORIGIN      
        1 attacccgtc aagaaacgag aaataaatct gtcagcgaca gaaggaacga gtaagttcaa
       61 acgcaaatta aagagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac
      121 atgcaagtag aacgctgaga actggtgctt gcaccggttc aaggagttgc gaacgggtga
      181 gtaacgcgta ggtaacctac ctcatagcgg gggataacta ttggaaacga tagctaatac
      241 cgcataagag agactaacgc atgttagtaa tttaaaaggg gcaattgctc cactatgaga
      301 tggacctgcg ttgtattagc tagttggtga ggtaaaggct caccaaggcg acgatacata
      361 gccgacctga gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg
      421 aggcagcagt agggaatctt cggcaatggg ggcaaccctg accgagcaac gccgcgtgag
      481 tgaagaaggt tttcggatcg taaagctctg ttgttagaga agaatgatgg tgggagtgga
      541 aaatccacca agtgacggta actaaccaga aagggacggc taactacgtg ccagcagccg
      601 cggtaatacg taggtcccga gcgttgtccg gatttattgg gcgtaaagcg agcgcaggcg
      661 gttttttaag tctgaagtta aaggcattgg ctcaaccaat gtacgctttg gaaactggag
      721 aacttgagtg cagaagggga gagtggaatt ccatgtgtag cggtgaaatg cgtagatata
      781 tggaggaaca ccggtggcga aagcggctct ctggtctgta actgacgctg aggctcgaaa
      841 gcgtggggag caaacaggat tagataccct ggtagtccac gccgtaaacg atgagtgcta
      901 ggtgttaggc cctttccggg gcttagtgcc ggagctaacg cattaagcac tccgcctggg
      961 gagtacgacc gcaaggttga aactcaaagg aattgacggg ggcccgcaca agcggtggag
     1021 catgtggttt aattcgaagc aacgcgaaga accttaccag gtcttgacat cccgatgccc
     1081 gctctagaga tagagtttta cttcggtaca tcggtgacag gtggtgcatg gttgtcgtca
     1141 gctcgtgtcg tgagatgttg ggttaagtcc cgcaacgagc gcaaccccta ttgttagttg
     1201 ccatcattaa gttgggcact ctagcgagac tgccggtaat aaaccggagg aaggtgggga
     1261 tgacgtcaaa tcatcatgcc ccttatgacc tgggctacac acgtgctaca atggttggta
     1321 caacgagtcg caagccggtg acggcaagct aatctcttaa agccaatctc agttcggatt
     1381 gtaggctgca actcgcctac atgaagtcgg aatcgctagt aatcgcggat cagcacgccg
     1441 cggtgaatac gttcccgggc cttgtacaca ccgcccgtca caccacgaga gtttgtaaca
     1501 cccgaagtcg gtgaggtaac ctattaggag ccagccgcct aaggtgggat agatgattgg
     1561 ggtgaagtcg taacaaggta gccgtatcgg aaggtgcggc tggatcacct cctttctaag
     1621 gaaatggaac acgtttatcg tcttatttag ttttgagagg tcttgtgggg ccttagctca
     1681 gctgggagag cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccat
     1741 caggatacaa tcctactaaa cttaatacaa gtgaagttga acacgcaact cacttcctag
     1801 gaaaatagac aatcttcgca tgtgtgcaag gcacacatgg tcagattcct aattttctac
     1861 agaagtttcg ctaaagcgag cgttgcttag tatcctatat aatagtccat tgaaaattga
     1921 atatctatat caaattccac gatctagaaa tagattgtag aaaagtaaca agaaaataaa
     1981 ccgaaaacgc tgtgactatt taataagttt tctagtttaa aaaaactagg ttaataaggt
     2041 taagttaata agggcgcacg gtggatgcct tggcactaga agccgaagaa ggacgtgaca
     2101 aacgacgaaa tgctttgggg agctgtaagt aagcgctgat ccagagatgt ccgaatgggg
     2161 gaacccacta actaatggtt agtatccata actgttaagg ttatgagaag gaagacgcag
     2221 tgaactgaaa catctaagta gctgcaggaa gagaaagcaa acgcgattgc cttagtagcg
     2281 gcgagcgaaa cggcaggagg gcaaaccgga gtgtttacac ttcggggttg taggactgcg
     2341 acgtgggact ttaaaaggat agaagaatta cctgggaagg taagccaaag agagtaaaag
     2401 cctcgtattt aaaattcttt tgagccctag cagtatcctg agtacggcga gacacgtgaa
     2461 atctcgttgg aatctgggag gaccatctcc caaccctaaa tactctctag tgaccgatag
     2521 tgaaccagta ccgtgaggga aaggtgaaaa gcaccccggg aggggagtga aatagaacct
     2581 gaaaccgtgt gcctacaaca agttcgagcc cgttaatggg tgagagcgtg ccttttgtag
     2641 aatgaaccgg cgagttacga tatgatgcga ggttaagttg aagagacgga gccgtaggga
     2701 aaccgagtct taatagggcg atttagtatc atgttgtaga cccgaaacca tgtgacctac
     2761 ccatgagcag gttgaaggtg aggtaaaact cactggagga ccgaaccagg gcacgttgaa
     2821 aagtgcttgg atgacttgtg ggtagcggag aaattccaaa cgaacttgga gatagctggt
     2881 tctctccgaa atagctttag ggctagcgtc gatgttaagt ctcttggagg tagagcactg
     2941 tttgggtgag gggtccatct cggattacca atctcagata aactccgaat gccaacgaga
     3001 tatcatcggc agtcagactg cgagtgctaa gatccgtagt cgaaagggaa acagcccaga
     3061 ccaccagcta aggtcccaaa ataactgtta agtggaaaag gatgtggggt tgcacagaca
     3121 actaggatgt tagcttagaa gcagctattc attcaaagag tgcgtaatag ctcactagtc
     3181 gagtgaccct gcgccgaaaa tgtaccgggg ctaaaacagt ttaccgaagc tgtggatgac
     3241 acaaaagtgt catggtagga gagcgttcta tgtgtgaaga aggtgtaccg tgaggagcgc
     3301 tggaacgcat agaagtgaga atgccggtat gagtagcgca agacaggtga gaatcctgtc
     3361 caccgtaaga ctaaggtttc caggggaagg ctcgtccgcc ctgggttagt cgggacctaa
     3421 ggagagaccg aaaggtgtat ccgatggcca acaggttgat attcctgtac tagagtatat
     3481 agtgatggag ggacgcagta ggctaactaa accggacgat tggaagagtc cggctaagca
     3541 gtgaggtgta agatgagtca aatgcttatc tttataacat tgagctgtga tggggagcga
     3601 attttagtag cgaagttagt gatgtcacac tgccaagaaa agcttctagc gtttaatgat
     3661 actctacccg taccgcaaac cgacacaggt agtcgaggcg agtagcctca ggtgatcgag
     3721 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctga
     3781 cttaggtcag ccgcagtgaa taggcccaag caactgttta tcaaaaacac agctctctgc
     3841 taaatcgtaa gatgatgtat agggggtgac gcctgcccgg tgctggaagg ttaagaggag
     3901 ggtttagcgc aagcgaagat ctgaattgaa gccccagtaa acggcggccg taactataac
     3961 ggtcctaagg tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgtaatg
     4021 atttgggcac tgtctcaacg agagactcgg tgaaatttta gtacctgtga agatgcaggt
     4081 tacccgcgac aggacggaaa gaccccatgg agctttactg cagtttgata ttgagtatct
     4141 gtaccacatg tacaggatag gtaggagcca ttgacttcgg gacgccagtt tcgaatgagg
     4201 cgttgttggg atactaccct tgtgttatgg ctactctaac ccagataggt tatccctatc
     4261 ggagacagtg tctgacgggc agtttgactg gggcggtcgc ctcctaaaga gtaacggagg
     4321 cgcccaaagg ttccctcaga ttggttggaa atcaatcgca gagtgtaaag gtataaggga
     4381 gcttgactgc gagagctaca actcgagcag ggacgaaagt cgggcttagt gatccggtgg
     4441 taccgaatgg aagggccatc gctcaacgga taaaagctac cctggggata acaggcttat
     4501 ctcccccaag agttcacatc gacggggagg tttggcacct cgatgtcggc tcgtcgcatc
     4561 ctggggctgt agtcggtccc aagggttggg ctgttcgccc attaaagcgg cacgcgagct
     4621 gggttcagaa cgtcgtgaga cagttcggtc cctatccgtc gcgggcgtag gaaatttgag
     4681 aggatctgct cctagtacga gaggaccaga gtggacttac cgctggtgta ccagttgtct
     4741 tgccaaaggc atcgctgggt agctatgtag ggaagggata agcgctgaaa gcatctaagt
     4801 gcgaagcccc cctcaagatg agatttccca tgattttata tcagtaagag ccctgagag
//
LOCUS       DAUDWO010000066         4712 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.067, whole genome shotgun sequence.
ACCESSION   DAUDWO010000066 DAUDWO010000000
VERSION     DAUDWO010000066.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4712)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4712)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4712
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.067"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            20..1216
                     /locus_tag="VHC05_001664"
     CDS             20..1216
                     /locus_tag="VHC05_001664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002996017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEQ5402942.1"
                     /translation="MKKRILSAVLVSGVTLGAATTVGAEDLSTKIAKQDSIISNLTTE
                     QKAAQNQVSALQAQVSSLQSEQDKLTARNTELEALSKRFEQEIKALTSQIVARNEKLK
                     NQARSAYKNNETSGYINALLNSKSISDVVNRLVAINRAVSANAKLLEQQKADKVSLEE
                     KQAANQTAINTIAANMAMAEENQNTLRTQQANLEAATANLALQLASATEDKANLVAQK
                     EAAEKAAAEALAQEQAAKVKAQEQAAQQAASVEAAKSAITPAPQATPAAQSSNAIEPA
                     ALTAPAAPSARPQTSYDSSNTYPVGQCTWGAKSLAPWAGNNWGNGGQWAYSAQAAGYR
                     TGSTPMVGAIAVWNDGGYGHVAVVVEVQSASSIRVMESNYSGRQYIADHRGWFNPTGV
                     TFIYPH"
     gene            1469..2431
                     /locus_tag="VHC05_001665"
     CDS             1469..2431
                     /locus_tag="VHC05_001665"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HEQ5402943.1"
                     /translation="MSYSDLKLFALSSNKELAEKVASAMGIQLGKSTVRQFSDGEIQV
                     NIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASAEKISVVMPYYGYARQDRK
                     ARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRH
                     GLVGEDVVVVSPDHGGVTRARKLAQFLQTPIAIIDKRRSVDKMNTSEVMNIIGNVSGK
                     KCILIDDMIDTAGTICHAADALAEAGATAVYASCTHPVLSGPALDNIQRSAIEKLIVL
                     DTIYLPKERLIDKIEQISIADLVAEAIIRIHEKRPLSPLFEMGN"
     gene            2617..3372
                     /gene="recO"
                     /locus_tag="VHC05_001666"
     CDS             2617..3372
                     /gene="recO"
                     /locus_tag="VHC05_001666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecO"
                     /protein_id="HEQ5402944.1"
                     /translation="MQLTESLGIVLFNRNYREDDKLVKIFTEVAGKQMFFVKHISRSK
                     MSSIIQPLTIADFIFKLNDTGLSYVVDYSNVNTYRYINNDIFRLAYASYVLALADAAI
                     ADNESDSHLFTFLKKTLDLMEEGLDYEILTNIFEIQILDRFGISLNFHECAICHRTDL
                     PLDFSHRFSAVLCSEHYYKDNRRNHLDPNVIYLLSRFQKITFDDLRTISLNKDIKKKL
                     RQFIDELYHDYVGIKLKSKTFIDNLVKWGDIMK"
     gene            3475..4482
                     /gene="plsX"
                     /locus_tag="VHC05_001667"
     CDS             3475..4482
                     /gene="plsX"
                     /locus_tag="VHC05_001667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012514701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HEQ5402945.1"
                     /translation="MKRIAIDAMGGDNAPKAIVEGVNQAIEAFSDIEIQLYGDQTKIN
                     SYLIQSDRVAIIHTDEKIMSDDEPAKAVRRKKKASMVLAAKAVKEGKADAIISAGNTG
                     ALLAVGLFVVGRIKGVDRPGLLSTIPTVTGLGFDMLDLGANAENTAKHLHQYAILGSF
                     YAKNVRGIANPRVGLLNNGTEETKGDPLRKATYELLTADNTISFVGNVEARELMSGVA
                     DVIVSDGFTGNAVLKSIEGTAISIMGQLKQIINSGGIKTKIGASLLKSSLYEMKKTLD
                     YSSAGGAVLFGLKAPVVKSHGSSDVKAIFSTIKQVRTMLDTNVVGQLVEEFAKETQVN
                     D"
     gene            4475..>4712
                     /locus_tag="VHC05_001668"
     CDS             4475..>4712
                     /locus_tag="VHC05_001668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017228.1"
                     /note="carries the fatty acid chain in fatty acid
                     biosynthesis; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HEQ5402946.1"
                     /translation="MTRQEIFERLINLIQKQRSYLSVAITEQTHLKNDLAVDSIELVE
                     FIINVEDEFHIAIPDEDVEDMVFMEDVLDYLVQRL"
BASE COUNT         1525 a          729 c          982 g         1476 t
ORIGIN      
        1 aggagtagtt ttttttatta tgaaaaaaag aattttatca gcagttcttg taagtggtgt
       61 taccctcgga gcagctacaa ctgtaggagc ggaggatttg agtactaaga ttgctaagca
      121 ggattctatt atctcaaatc tgactacaga gcaaaaagct gcacagaatc aagtttcagc
      181 gttacaggct caagtaagtt cactacaatc tgaacaagat aaactgaccg caagaaatac
      241 agaacttgag gcactttcaa agcgatttga gcaagaaatt aaggctctaa caagtcaaat
      301 tgttgctcgt aatgaaaaat taaaaaatca agctcgtagt gcttataaaa acaatgaaac
      361 ttctggttac attaatgcac ttttgaattc taaatcaatt tctgatgttg taaaccgttt
      421 agtagcaatt aatagagctg tctctgctaa cgctaaattg ttagaacaac aaaaagctga
      481 taaagtttcc cttgaagaaa agcaagctgc taaccaaaca gctattaata ccattgccgc
      541 taatatggca atggctgaag aaaaccaaaa tacattacgt actcaacaag ctaatttgga
      601 agctgcaact gcaaatttag ctctccaatt agcatctgct actgaagata aagctaattt
      661 ggtagctcaa aaagaagctg cagaaaaagc tgctgctgaa gccttagcac aagaacaggc
      721 tgctaaagtt aaggcacaag aacaggctgc acaacaagca gcatctgttg aagcagcaaa
      781 atctgctatt actccagcac cacaagctac tccggcagcg caaagtagta atgctattga
      841 accagctgca ctcacggctc cggcagctcc ttctgcaaga ccacaaacat catatgattc
      901 ttctaatact tatccagttg gacaatgcac atggggagct aaatctttag ctccttgggc
      961 aggaaataat tggggaaatg gtggtcaatg ggcttatagt gctcaagcag ctggttatcg
     1021 tactggttca acgccgatgg taggtgcgat tgccgtttgg aacgatggtg gttatggaca
     1081 tgtcgccgtt gtagttgagg ttcaaagtgc ctcaagtatt cgtgtgatgg agtctaacta
     1141 cagtggtaga cagtacattg ctgatcaccg tggttggttt aatccaacag gtgttacatt
     1201 tatttatcca cactaacata ttatttaggt tagaacagtt gttctaacct ttttgattat
     1261 tcctattgtg gaatagttct gagagtattg acgatatagt taatttataa gagagttgtt
     1321 tggccaatcg cttatgtata atataagaga agtatataaa gtcgataaaa gatatattta
     1381 atacattctt taacggtttt tcaatttcat ttgataattc acttgaaaag cgttaaaatg
     1441 gtataggatt aaaactttgg aggaaaaaat gtcttattct gatttaaaat tgtttgcttt
     1501 atcgtcaaac aaggaattag cagaaaaagt tgcgtctgca atgggtattc aacttggaaa
     1561 gtctacggtt cgtcagtttt cagatggtga aatccaagta aatattgaag aatcaattcg
     1621 tggtcatcat gtctttattt tgcaatcaac tagctcacct gtcaatgaca atttaatgga
     1681 aattttgatt atggtcgatg ctttaaagcg tgctagtgct gaaaaaattt cagttgtgat
     1741 gccttactac ggctatgcac gccaagaccg taaagcgcgt tctcgtgaac ctattacttc
     1801 aaaattagtt gctaatatgt tagaagttgc tggtgtagat cgcttattaa cggttgattt
     1861 acatgctgct caaattcaag ggttctttga tattccagtt gatcacttga tgggtgcacc
     1921 tttaattgca gactattttg atcgtcatgg tttagtgggt gaagatgttg tcgttgttag
     1981 tcctgaccat ggtggtgtga ctcgtgcgcg taaattagca caattcctcc aaacaccaat
     2041 tgcaattatc gataagcgtc gtagtgtgga taagatgaac accagtgaag tgatgaatat
     2101 tatcggaaat gtttcgggca agaaatgtat cttgattgac gatatgattg ataccgcagg
     2161 gactatttgc catgcagcag atgcgcttgc tgaagcgggg gcaacagctg tgtatgcgtc
     2221 atgtacgcat cccgttcttt ctgggccagc acttgataat attcaacgtt cggctatcga
     2281 aaaactaatt gttcttgata ctatttatct gccaaaagaa cgtcttattg ataaaattga
     2341 acaaatttca attgctgatt tggttgcaga agcgattatt cgtattcatg aaaaacgtcc
     2401 gttgtcacct ttatttgaga tgggcaatta agcttaacga agcctgagat aatagatctc
     2461 gggctttttg acttgaataa aatgtaaggg taatgtggta ttaattattg tgggatgaac
     2521 tatgcaattc taaaggattt tgggtataat aagaaagata acaacagttt attgtaaact
     2581 aagataaaag gtaagagaaa aatacgacga ggtaatatgc aactaacaga atcactaggc
     2641 attgttcttt ttaataggaa ttatcgagaa gatgataaat tagtcaaaat atttactgaa
     2701 gtagcaggta agcagatgtt tttcgtgaaa catattagtc gttccaaaat gtcctcaatc
     2761 attcaaccac taacgattgc tgattttatt ttcaagttaa atgatacagg cttgtcttat
     2821 gttgttgact atagtaacgt taacacttat cggtatatta ataatgatat ttttcgatta
     2881 gcctatgcta gttatgtctt agcattagct gatgctgcga ttgcagataa tgaatcagat
     2941 tcgcatttgt ttacgttttt gaaaaaaaca cttgatttga tggaagaggg cctagattat
     3001 gaaattttga caaatatttt tgaaattcag atattagatc gttttggtat tagtctaaac
     3061 tttcatgagt gtgccatttg tcatcgcact gatttaccgc ttgatttttc ccatcgtttt
     3121 tcagctgtac tttgttctga acattattac aaagacaacc gacgtaatca tttagatcca
     3181 aatgttatct acttgttgag tcgatttcaa aaaatcacat ttgatgattt gagaactatt
     3241 tcattgaata aagacatcaa aaagaagctt cgtcagttca ttgatgagtt gtatcacgac
     3301 tatgtaggaa tcaaattaaa aagtaaaaca ttcattgata atttagttaa gtggggagat
     3361 attatgaaat gatagggcct ctttcgttta tgggaattgg tttcagaata tgctataata
     3421 aaaatactat taatagattg tgtaagaaca caagatataa ttaaaggagt ggaaatgaag
     3481 agaattgcaa tagatgctat gggtggagat aacgctccta aagctattgt tgagggtgtt
     3541 aatcaagcaa tagaagcatt ttcagatatc gaaattcaac tttacggtga tcagacaaag
     3601 attaactcct atcttattca atcagatcgt gttgctatta ttcatacaga tgaaaaaatt
     3661 atgtcagatg atgaacctgc aaaagctgtt cgccgtaaaa agaaggcttc aatggtttta
     3721 gcagctaagg cagtgaaaga aggaaaagca gatgccatta tttcagcagg gaatacaggt
     3781 gctcttttag ctgtaggttt gtttgttgtg gggcgtatca agggagttga tcgtccagga
     3841 ttattatcaa ctattcccac agtaaccgga ttaggatttg atatgttgga tcttggagct
     3901 aatgctgaaa atacggcaaa acatttacat caatatgcta ttttaggctc tttctatgct
     3961 aagaatgtac gtgggattgc taatccacgt gttggtctat taaacaatgg tacagaagaa
     4021 acaaaaggag atccccttcg taaggccact tatgaacttt taacagcaga taatacaata
     4081 tcttttgttg gtaatgtcga ggcgcgagaa cttatgtcag gtgttgcaga tgttattgta
     4141 tcagatggtt tcacgggaaa cgcagtgttg aaatcaatag aaggaacagc tattagcatt
     4201 atggggcaac tgaaacagat aattaatagc ggcggtatta agactaaaat tggagctagt
     4261 ctacttaaaa gtagtcttta cgagatgaag aagactcttg actactctag tgctggaggt
     4321 gcagttttat ttggtttaaa ggcacctgtt gtaaagtctc atggttctag tgatgtaaaa
     4381 gctatttttt caacgataaa acaagtacgt acgatgctag acactaacgt ggtcggacaa
     4441 ttagtagaag aatttgctaa ggagactcaa gtaaatgact agacaggaga tttttgaaag
     4501 gctgattaac ttaattcaga agcaaagaag ctatttgagt gtagctatta cagaacaaac
     4561 acatttaaaa aatgatttag cggttgactc tattgaacta gttgaattta ttattaatgt
     4621 tgaagatgaa tttcatattg ctattcctga tgaagatgtt gaggatatgg tatttatgga
     4681 agacgtttta gattatttag ttcagcgttt ga
//
LOCUS       DAUDWO010000067         4619 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.068, whole genome shotgun sequence.
ACCESSION   DAUDWO010000067 DAUDWO010000000
VERSION     DAUDWO010000067.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4619)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4619)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4619
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.068"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            90..632
                     /gene="hpt"
                     /locus_tag="VHC05_001669"
     CDS             90..632
                     /gene="hpt"
                     /locus_tag="VHC05_001669"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012961310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HEQ5402947.1"
                     /translation="MLEQDIQKILYSENDIIRKTKKLGEQLTKDYQEKNPLMIGVLKG
                     SVPFMAELMKHIDTHVEIDFMVVSSYHGGTSSSGEVKILKDVDTNIEGRDIIIVEDII
                     DTGRTLKYLRDMFKYRKANTIKIATLFDKPEGRVVKIEADYVCYNIPNEFIVGFGLDY
                     AENYRNLPYVGVLKEEVYSK"
     gene            654..2633
                     /gene="ftsH"
                     /locus_tag="VHC05_001670"
     CDS             654..2633
                     /gene="ftsH"
                     /locus_tag="VHC05_001670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HEQ5402948.1"
                     /translation="MKNNKNNGFVKNSFIYILMIIVVITGFQFYLKGTSTQSQQISYS
                     KLIKHLKAGDIKSLSYQPSGSIIEVKGKYEKPQKVTVNSGLSFLGGRASTQVTEFSSL
                     VLPSDTILKEMTAAADKNGTELTVKQESSSGTWITFLMSFLPIVIFAAFMMMMMNQGG
                     GGARGAMSFGKNKAKSQSKGDVKVRFTDVAGAEEEKQELVEVVDFLKNPKKYKSLGAR
                     IPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAK
                     KAERAIIFIDEIDAVGRRRGAGMGGGNDEREQTLNQLLIEMDGFEGNENIIVIAATNR
                     SDVLDPALLRPGRFDRKVLVGRPDVKGREAILRVHAKNKPLANDVNLKVVAQQTPGFV
                     GADLENVLNEAALVAARRNKIKIDASDIDEAEDRVIAGPSKKDRTISQKEREMVAYHE
                     AGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDLKEQLAGLMGGR
                     VAEEIVFNAQTSGASNDFEQATQIARAMVTEYGMSEKLGPVQYEGNHAMMPGQISPEK
                     AYSAQTAQMIDDEVRELLNQARNQAADIINENRDTHKLIAEALLKYETLDAAQIKSIY
                     ETGKMPVDLETDDNEAHALSYDEIKNKMTESESAE"
     gene            2960..4351
                     /locus_tag="VHC05_001671"
     CDS             2960..4351
                     /locus_tag="VHC05_001671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HEQ5402949.1"
                     /translation="MTIFRKKKKYSNKTEMQRHFKVIDLVFLGLGSMVGTGIFTVTGI
                     GAAKYAGPALTISIIISAITIGILALFYAEFASRMPSNGGAYSYVYATLGEFPAWLVG
                     WYIIMEFLTAISSVAVGWGSYLKGLLANYNIVLPNALNGTFNLKNGTYIDILPVLVMF
                     FVTGIVLMNSKLALRFNSFLVILKFSALALFIFVGIFFIDHNNWSHFAPYGVGQITGG
                     KTGIFAGASVMFFAFLGFESISMAVDEVKEPQKTIPKGIILSLIIVTALYIVVTTILT
                     GIVHYTKLNVPDAVAFALRNIRLYWAADYVSIVAILTLITVCISMTYALARTIYSISR
                     DGLLPKSLYTLTKKNKVPQNATLVTGLLAMICAGIFPLSSLAEFVNICTLAYLIILSG
                     AIIKLRRIEGEPKANEFKTPLVPFLPILAIIICLSFMSQYKAFTWIAFAIATIIGTLI
                     YLAYGYTHSIENK"
BASE COUNT         1554 a          661 c          882 g         1522 t
ORIGIN      
        1 aggtaataaa acttatttga gaaaagcttg taaacatgat ataatgttgg ctaaactgta
       61 tattgataaa ttagaaaaag ggtgacagca tgctcgagca agatattcaa aaaattcttt
      121 actctgaaaa tgatattatt cggaaaacca aaaaattagg agaacaatta acaaaagatt
      181 atcaagaaaa aaatccgctt atgattggtg tattaaaagg atcagttcct tttatggcag
      241 aactaatgaa acacatcgat actcatgttg aaattgattt tatggtagta tcaagttatc
      301 acggcggtac atctagcagt ggtgaagtta aaattttaaa agatgtagat accaatattg
      361 aaggaagaga tatcataatt gttgaagata ttattgacac cggtcgcacc ttaaaatatt
      421 tacgagatat gtttaagtac cgtaaagcta atactatcaa aattgcaaca ctgtttgata
      481 aacctgaagg tcgtgttgtt aaaattgaag cagattatgt ttgttacaat attccaaatg
      541 aatttatcgt aggttttggt ttagattacg cagaaaatta tcgcaatctt ccttacgtag
      601 gtgtattaaa agaagaagtc tattcaaaat agaaaaaggt caatgtttac tgtatgaaaa
      661 ataataaaaa taatggtttt gttaaaaatt cttttatata tatattgatg attattgttg
      721 tcatcacagg atttcaattt tatcttaagg gaaccagcac acaaagccaa cagattagtt
      781 attccaaatt aattaaacat cttaaggctg gagatataaa atctttaagt tatcagccta
      841 gcggtagtat tattgaagtt aaagggaaat atgagaaacc tcaaaaagtg acagttaatt
      901 caggactatc atttttaggt ggaagagctt caacacaggt aacagagttc tcatctttag
      961 tattacctag tgataccatc ttgaaagaaa tgacagcagc agctgataaa aatggaacag
     1021 agcttacagt taagcaggaa agttcaagtg gtacttggat taccttctta atgagctttt
     1081 tacctattgt tatttttgct gctttcatga tgatgatgat gaatcaaggt ggtggaggag
     1141 ctcgtggtgc tatgagtttc ggcaaaaata aggcaaaatc tcaatcaaaa ggtgatgtta
     1201 aagtgagatt tacagacgtt gctggtgccg aagaagaaaa acaagaatta gtagaagttg
     1261 ttgatttttt gaaaaatcct aaaaaatata aatcactagg agcacggatt ccagcgggag
     1321 ttcttctaga ggggcctcca ggtactggta aaacattact agctaaagct gtagcaggtg
     1381 aagctggagt gccatttttc agtatttcag gttcagattt tgtcgaaatg tttgtcggtg
     1441 taggtgctag tcgtgttcgt tctttatttg aggatgctaa aaaagctgag cgtgcgatca
     1501 tctttatcga tgaaattgac gctgtaggtc gtcgtcgtgg tgctggcatg ggaggcggta
     1561 acgatgaacg agaacaaacc cttaaccaat tactcattga aatggatggt tttgagggta
     1621 atgagaacat tatcgttatt gctgcaacta accgtagtga tgttttagat ccagctttac
     1681 taagaccagg tcgttttgat cgtaaggttt tagttggtcg ccctgatgtt aaaggacgtg
     1741 aagccatttt acgtgttcat gctaaaaata aaccacttgc aaatgacgtt aatttgaaag
     1801 tagtagccca acagactcca ggttttgtag gtgctgatct tgaaaatgtt ttaaatgaag
     1861 ctgcgttagt tgctgctcgc agaaataaaa ttaaaattga tgctagtgat attgatgaag
     1921 ctgaagatcg tgttattgct ggaccatcaa agaaagatcg cactatttcg caaaaagagc
     1981 gagaaatggt tgcttatcac gaagctggtc atactattgt tggtttagtt ttatctaatg
     2041 cgcgtgtagt tcacaaggta actattgtac ctcgtggacg agcaggtggt tatatgatcg
     2101 ctcttccaaa agaagatcaa atgcttcttt ctaaagaaga tctgaaagag caattagcag
     2161 gattgatggg tggtcgtgtt gctgaagaaa ttgtttttaa tgctcaaaca tcaggtgcgt
     2221 caaatgactt tgagcaagct actcagatag caagggccat ggttacagaa tatggtatga
     2281 gtgaaaagct tggaccagtt caatatgaag gtaaccatgc gatgatgcca ggacagatct
     2341 ctcctgaaaa agcttactct gcccaaacag ctcaaatgat tgatgatgag gttcgtgaac
     2401 tcttaaatca agctcgtaat caagcagctg atatcatcaa tgagaatcga gatactcata
     2461 aattgattgc tgaagctctt ctcaaatatg aaactctaga cgctgcacaa attaaatcaa
     2521 tttatgaaac tggtaaaatg ccagttgatt tagaaactga tgataatgaa gctcatgcgt
     2581 tatcttatga cgaaattaaa aataaaatga cagaatctga atctgcagaa tgatataaaa
     2641 aagctgaact tatagattaa gttcagcttt tttatcaaca caatatcctt gtaaacgtta
     2701 tgaattgtaa taggtgccta attgctagaa atgagaagat gacatacttt tttttcttta
     2761 ttacttaaag tgagaaagac tttgatattt aaaactagaa aattgttaaa gccatttgaa
     2821 aaaatctatt agtgttttct tagaataata gaagaacaga agatagcaaa agtttcagtc
     2881 aaccaataag atgaaattta caatcattac taactatgat acacttagta gaaaatcatt
     2941 tactatagaa ggtgataaca tgactatttt tcgtaaaaaa aagaaatatt ccaataaaac
     3001 agaaatgcaa aggcacttca aagttattga tttagttttt ttaggcctag gttcaatggt
     3061 tggaacaggt atctttacag ttactggcat aggcgctgct aagtatgcag gtcctgcttt
     3121 aacaatatcg attatcattt ccgcgattac tattggaatt ttagccttat tttatgcaga
     3181 atttgcgtct cgtatgcctt ctaacggtgg tgcttatagt tatgtttatg caaccttggg
     3241 agagtttcca gcatggcttg ttggctggta tattattatg gaatttttaa cagctatatc
     3301 tagtgttgct gttggctggg gaagttattt aaaaggatta cttgccaatt ataatatagt
     3361 attaccaaac gctttaaatg gcacgttcaa tcttaagaat ggaacttaca tagatattct
     3421 tcctgtttta gtgatgtttt tcgtgacagg gattgtccta atgaattcga aattagctct
     3481 gagattcaat agttttttag ttattttaaa attttcagca ctggctttat ttatctttgt
     3541 aggcattttt tttattgatc acaataattg gtctcatttt gctccatatg gtgtaggaca
     3601 aattactgga ggtaaaacag gtatctttgc tggtgcttct gttatgttct ttgcattttt
     3661 aggatttgaa tctatttcaa tggcagttga tgaagtgaaa gaaccacaaa aaacaattcc
     3721 taaaggtatc attttatctt tgattattgt aacagcactc tatatagttg tcaccactat
     3781 tttaacggga attgtacact acactaaatt aaatgttcca gacgcggtgg cttttgcttt
     3841 aagaaatatt agactttatt gggcagctga ctatgtgtcg atagttgcta ttttgactct
     3901 tattacggta tgtatttcta tgacttatgc attagctaga acaatttaca gtattagtag
     3961 agatggttta ttacctaaat cactttatac tctcactaaa aaaaataaag tgcctcaaaa
     4021 tgctactctt gtcactggac tacttgctat gatttgtgcg ggaatatttc ctttatcgag
     4081 tctagcagag tttgttaata tttgtacttt agcatattta attattctgt cgggtgcaat
     4141 tattaaactc agaagaatag aaggagaacc aaaagcaaat gaatttaaaa ctcctctagt
     4201 accattccta ccaatattgg caattatcat ttgtctatca tttatgagcc aatataaagc
     4261 ttttacttgg attgcttttg ctattgccac aattattgga acattaatct acttagctta
     4321 tggttatact cattcaatag aaaataaata atgttttgat aataagattt gacattacat
     4381 tatagactat aatgtttaga agtaaatgag tagtaaaatc aatacctact tacttatcaa
     4441 agttgtaata tttaaaatta cccaacccct agagaattga ttagtctcta ggggttgatt
     4501 ggcacaatga catagactct aaaacgattt taatactaaa tatatagata taaatttcaa
     4561 aaaagaaaat tagttcattt ttgttacaca ataaaatttg ttatttagca gtaatataa
//
LOCUS       DAUDWO010000068         4417 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.069, whole genome shotgun sequence.
ACCESSION   DAUDWO010000068 DAUDWO010000000
VERSION     DAUDWO010000068.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4417)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4417)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4417
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.069"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            21..821
                     /locus_tag="VHC05_001672"
     CDS             21..821
                     /locus_tag="VHC05_001672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012516307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="HEQ5402950.1"
                     /translation="MGLTIFKKLVSLIILLLFFAILKRVTNYLFEKTINKSFAYSRQS
                     EARKKTLSKLTHNILNYLLYFLLIYWILSLFGIPVSSLLAGAGIAGVAIGLGAQGFLS
                     DVVNGFFILFENQFEVGDNVTISDIEGSVFGVGIRTTQIRGFDGTLHFIPNRSITVVS
                     NKSRGNMRALIEIPLYSTVNLSQVTRIIDEVNQKELPNHPQIVGKPNILGPQNNSNGQ
                     FTFRIAIFTENGEQFKIYHTFYRLYQEALLKEGIQLPTAISYSITSKS"
     gene            complement(886..1446)
                     /locus_tag="VHC05_001673"
     CDS             complement(886..1446)
                     /locus_tag="VHC05_001673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01440 family protein"
                     /protein_id="HEQ5402951.1"
                     /translation="MLNNLEKQTREIVIDVVERSAIQPGNLFVLGLSSSEILGSRIGK
                     QSSLEVGQIVVEVVLDELNKRGVHLAVQGCEHVNRALVVERHVAESKQLEIVNVVPNL
                     HAGGSAQMAAFQLMSDPVEVEEVIAHAGLDIGDTAIGMHIKRVQIPLIPCQRELGGAH
                     VTALASRPKLIGGARADYNMDIIRKS"
     gene            complement(1460..1930)
                     /locus_tag="VHC05_001674"
     CDS             complement(1460..1930)
                     /locus_tag="VHC05_001674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEQ5402952.1"
                     /translation="MQNSKIRQMSLTGILTALVVVLGRFVMLPTPTGFLTLLDAGIYA
                     VSFSFGSAQGAIVGGLSGFLIDLVAGYPQWMFHSLIAHSVQGYFAGWRGRKRWFGVVI
                     GSFIMIFWYFLGSLMLGYGLSGSLAGIWGNVMQNTLGLFVGFIIFKAILRQKKR"
     gene            complement(1920..2684)
                     /locus_tag="VHC05_001675"
     CDS             complement(1920..2684)
                     /locus_tag="VHC05_001675"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HEQ5402953.1"
                     /translation="MKTDYIVTISGNDILSGGGLYADLATYIRYDLQAFVAVTCLTTR
                     SEEGFSLFPVAKEIFRDQLNSFTNAPISAIKIGLLPNAEMCEIVLDFIKGHVGIPVVL
                     DPVLACKEIDDVKIVPLRQEILQLLPYVTVVTPNLVEAQLLSQKEIVSLKDMQEAAKY
                     FYQLGAKQVVIKGGNRFSQKKAIDLFYDGKEIVTLECPVLEKNNIGAGCTFASSIASQ
                     LVKKKTPLEAVKNSKELVYQAILQSDRYGVKQSYAK"
     gene            complement(2674..3423)
                     /gene="truA"
                     /locus_tag="VHC05_001676"
     CDS             complement(2674..3423)
                     /gene="truA"
                     /locus_tag="VHC05_001676"
                     /EC_number="5.4.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HEQ5402954.1"
                     /translation="MVRYKATISYDGTLFSGFQRQRHLRTVQEEIEKTLYKLNNGTKI
                     IIHGAGRTDAGVHAYGQVIHFDLPQEQEVEKLRFALDTQTPEDIDVVNIEKVADDFHC
                     RYQKHLKTYEFLVDNGRPKNPMMRHYTTHYPYTLNIKLMQEAINGLVGTHDFTGFTAA
                     GTSVQNKVRTITKATVSRDEKTDFLVFTFSGNGFLYKQVRNMVGTLLKIGNGQMPVEQ
                     VKVILSSKNRQLAGPTISGNGLYLKEICYEN"
     gene            complement(3610..4191)
                     /locus_tag="VHC05_001677"
     CDS             complement(3610..4191)
                     /locus_tag="VHC05_001677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEQ5402955.1"
                     /translation="MHNEKNNRTLVSCCFFVVLFILGIVKKKRRLKMSIETRAAFEKV
                     KPIILKLKRHYYIQLWDRDDWLQEGHIILLQLLERYPELIEEEERLYRYFKTKFSSYL
                     KDLLRRQESQKRQFHKLAYEEIGEVAHAIPSRGLWLDDYVAYQEVIASLENQLNSQER
                     MQFQALIRGERFKGRRALLRKISPYFKEFAQQL"
     gene            complement(4187..4260)
                     /locus_tag="VHC05_001678"
     tRNA            complement(4187..4260)
                     /locus_tag="VHC05_001678"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(4224..4226),aa:Arg,seq:acg)
     gene            complement(4340..4413)
                     /locus_tag="VHC05_001679"
     tRNA            complement(4340..4413)
                     /locus_tag="VHC05_001679"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(4377..4379),aa:Asn,seq:gtt)
BASE COUNT         1397 a          980 c          652 g         1388 t
ORIGIN      
        1 agcagtctca tatcgaaaat attggcttaa cgatttttaa aaagctagtg tctctcatta
       61 ttctattact cttttttgct attttaaaac gtgttactaa ctatcttttt gaaaaaacca
      121 ttaacaaatc gtttgcttat tcaagacaaa gtgaagctcg caaaaaaaca ctctctaagc
      181 tcactcacaa cattttaaat tacttattgt attttcttct catttattgg atacttagct
      241 tatttggcat acctgtctct agtcttctag caggagctgg aattgctgga gtagcaatcg
      301 ggttaggtgc acagggattt ttatctgacg ttgtcaatgg cttttttatc ttatttgaga
      361 atcaatttga agtaggagat aacgttacta tctctgacat agaaggcagt gtctttggtg
      421 ttggaattag aactactcaa attcgtggat tcgatggaac actacatttc atcccaaacc
      481 gtagcatcac cgttgtcagc aacaaatctc gtggtaatat gcgtgcctta attgaaattc
      541 ctctttattc cactgttaat ttgagccaag tcactcgaat cattgatgaa gtgaatcaaa
      601 aggaattgcc aaaccatcct caaatcgttg gcaaaccaaa tattttaggg cctcaaaata
      661 actctaatgg acagttcact tttagaattg ctattttcac agaaaatgga gaacaattta
      721 agatttacca tactttttat agactttatc aagaagcttt actcaaagaa ggcattcaat
      781 taccgactgc aatcagctat tctatcacct caaaatctta atataatctt aaaaaatcct
      841 tttttctaga aaaaacacca attgttttat tccagaaaaa agggtttagg atttacggat
      901 aatatccata ttgtaatcag ccctagctcc accaattaat tttggtcgac tagccaaagc
      961 tgtcacatga gcacctccta gctctcgttg acaaggaatc agagggatct gaacacgctt
     1021 aatatgcatt cctatagcag tatcacctat atcaagtcca gcgtgtgcaa taacttcttc
     1081 tacttcgaca gggtctgaca taagttgaaa agcagccatc tgagcactgc caccagcatg
     1141 aagattcgga accacattga caatctctaa ctgcttagat tctgccacat gcctctctac
     1201 taccaaggca cgattgacgt gttcacaacc ttgtacagcc aaatgaacac cacgcttatt
     1261 taactcatct aacacaactt caacaactat ttgacctact tctagactag attgttttcc
     1321 aattctacta cccaaaattt cgctagatga aagacctaga acaaaaagat tacctggttg
     1381 aatagcagag cgttctacaa catcaataac gatttccctt gtttgtttct ctaaattatt
     1441 caacaacttc tcactctcct tatctctttt tttgccttaa tatggcctta aagataataa
     1501 aaccaacaaa aagtcctaat gtattttgca tgacgtttcc ccaaataccg gctaaagatc
     1561 ccgaaaggcc ataaccaagc ataagagagc ctaaaaaata ccaaaaaatc atgataaaag
     1621 aacctatcac aacaccaaac caacgcttgc gtcctctcca tcccgcaaaa tacccttgga
     1681 cactgtgagc aatcaaacta tgaaacatcc actgagggta tcctgccact aaatcgatta
     1741 aaaaacctga taaccctccc acaatagctc cttgagctga tccaaaggaa aagctgacag
     1801 cataaattcc tgcatccaac agcgttaaaa aacctgttgg agtaggtagc atgacaaatc
     1861 ttcctaaaac aacaaccaat gctgtcaata tccctgttaa actcatttgt cgtatcttac
     1921 tattttgcat aactttgttt tactccgtat ctatcagatt gtaaaatagc ttggtagact
     1981 aactcttttg agtttttcac agcttctagt ggcgtttttt tctttactaa ctgactagcg
     2041 atactagatg caaaagtaca gcctgcgcca atattatttt tctcaagtac aggacattcc
     2101 aaggtaacaa tctctttacc gtcataaaaa agatcaatag cctttttctg actaaatcga
     2161 ttaccaccct tgataaccac ctgttttgcc ccaagttgat aaaaatattt agcagcttct
     2221 tgcatatctt ttaaagaaac aatctctttt tgagataata gctgagcctc taccaaattt
     2281 ggagtaacaa cagttacata aggcaataat tgtaaaatct cctgtcttag aggaactatt
     2341 ttaacatcat ctatttcttt acatgctaga acaggatcta aaaccactgg gattcccaca
     2401 tgccccttta taaaatccaa aactatttca cacatttccg cattaggtaa caaaccaatt
     2461 ttaatagcag aaattggagc gttcgtaaag ctgttcaact gatcacggaa aatttcttta
     2521 gctaccggaa atagactaaa gccctcttca gatctagtag ttaaacaagt taccgctaca
     2581 aaggcctgta ggtcatacct tatgtaagtc gctaaatcag catagaggcc acctccactt
     2641 aaaatatcgt tcccagatat agtcacgata taatcagttt tcataacaaa tctccttcaa
     2701 gtaaagccca tttccagata tcgttggtcc agctagctga cgatttttgg agctcaaaat
     2761 cactttaact tgttcaactg gcatttgacc attaccaatt ttcagcaaag ttcccaccat
     2821 attcctcacc tgcttataga gaaaaccatt tcctgaaaaa gtaaacacca aaaaatcagt
     2881 tttttcatcc cgagataccg ttgctttggt aatcgttcgc accttatttt gtaccgaagt
     2941 tcctgctgct gtaaaaccag taaaatcgtg tgtgcctacc agaccgttaa tagcttcttg
     3001 cataagttta atattaagag tataagggta atgagtggta tagtgtcgca tcatcggatt
     3061 tttaggtcga ccattatcaa ctaaaaattc ataagttttt aaatgcttct gataacgaca
     3121 atgaaaatca tcagccactt tttctatatt aacaacatca atatcttcag gagtctgtgt
     3181 atcaagagca aatcgtaatt tttcaacttc ttgttcttga ggcaaatcaa aatggatcac
     3241 ctgtccataa gcatgtactc ctgcatccgt acgtcctgca ccatgaatta taatttttgt
     3301 accgttattt aatttataga gtgttttttc aatctcttct tgaaccgtac gtaaatgtct
     3361 ttgtctttga aaacccgaaa aaagagtccc atcataggaa atcgttgctt tgtatcttac
     3421 catgttacta ttttaacatt tcttaaacgt aagagaaact atttttaatc aaactgtacc
     3481 caaacaaatg aaagacgtat tgaagctaac tctaagctac taacgattta aaagctataa
     3541 gaaagctatt tcctccaaac tctctctcct ttttttatag atttaccccc aattccttat
     3601 aggtcttgct tacaactgct gtgcaaattc cttaaaatag ggactgatct tcctaagtag
     3661 agcacgtctt cccttgaaac gttcgcccct gataagtgct tgaaactgca tacgctcttg
     3721 cgaatttaat tggttctcta agctagctat tacctcttga taagccacat agtcgtctag
     3781 ccataaccct ctcgatggaa tggcatgtgc aacctcccct atctcttcat atgctaactt
     3841 atggaactga cgcttttgac tttcttgacg gcgtaataaa tctttcaaat aagatgaaaa
     3901 ttttgtttta aaatagcgat ataaacgctc ttcttcctca attaactctg ggtacctttc
     3961 tagtaactgt aataagataa tatgtccttc ttgtaaccag tcatctctat cccacaattg
     4021 aatataatag tgtcgcttta atttcaaaat aatgggctta actttttcaa acgctgctct
     4081 tgtctctatc gacattttga gtctcctttt ctttttaact atccctagta taaagagaac
     4141 cacaaaaaaa caacaggaca ctaatgtcct gttgtttttt tcattatgca ccctagagga
     4201 gtcgaacctc taaccgcctg attcgtagtc aggtactcta tccagttgag ctaagggtgc
     4261 caacgcatat cttgcctcta tcttaccaca ctcttctcta aaatgcaaaa aaagatagga
     4321 cgcttcctac ctatctctac tccgccagta ggactcgaac ctacgacatc atgattaaca
     4381 gtcatgcgct actaccaact gagctatggc ggataaa
//
LOCUS       DAUDWO010000069         4396 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.070, whole genome shotgun sequence.
ACCESSION   DAUDWO010000069 DAUDWO010000000
VERSION     DAUDWO010000069.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4396)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4396)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4396
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.070"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(283..1404)
                     /gene="mnmA"
                     /locus_tag="VHC05_001680"
     CDS             complement(283..1404)
                     /gene="mnmA"
                     /locus_tag="VHC05_001680"
                     /EC_number="2.8.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017769308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="HEQ5402956.1"
                     /translation="MTDNSKIRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDT
                     DEFGVCTATEDYKDVAAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVM
                     CNKEIKFKAFLDYAMTLGADYVATGHYAQVKRDENGTVHMLRGADNGKDQTYFLSQLS
                     QEQLQKTLFPLGHLQKSEVREIAERAGLATAKKKDSTGICFIGEKNFKQFLSQYLPAQ
                     KGRMMTIDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNQPWFVVGKDLSQNILYVGQ
                     GFYHEALMSNSLDASVIHFTREMPEEFTFECTAKFRYRQPDSQVTVHVRGDKAEVVFA
                     EPQRAITPGQAVVFYDGKECLGGGMIDMAYKNGQPCQYI"
     gene            1702..2373
                     /gene="sdaAB"
                     /locus_tag="VHC05_001681"
     CDS             1702..2373
                     /gene="sdaAB"
                     /locus_tag="VHC05_001681"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent
                     subunit beta"
                     /protein_id="HEQ5402957.1"
                     /translation="MNTQKFQSVFDIIGPVMIGPSSSHTAGAVRIGKVVHSIFGDIPD
                     EVTFHLYNSFAKTYRGHGTDKALVAGIMGMDTDNPDIKNSLEIAHQKGIKIYWDILKD
                     SNAPHPNTVKISVKKADKTLSVTGVSIGGGNIQVTELNGFSVSLSMNTPTIVTVHKDI
                     PGMIAKVTDILSSNNINIATMNVTRESAGEKATMIIEVDSRECQEAANQIAKIPHIYN
                     VNFFD"
     gene            2385..3257
                     /gene="sdaAA"
                     /locus_tag="VHC05_001682"
     CDS             2385..3257
                     /gene="sdaAA"
                     /locus_tag="VHC05_001682"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent,
                     subunit alpha"
                     /protein_id="HEQ5402958.1"
                     /translation="MFYTIEELVKQADQQFNGNIAELMIATEVEMSGRNREDIIKIMS
                     RNLQVMKAAVTEGLTSTKSISGLTGGDAVKMDNYIKKGNSLSDTTILNAVRNAIAVNE
                     LNAKMGLVCATPTAGSAGCLPAVLATAIEKLDLSEKKQLEFLFTAGAFGLVIGNNASI
                     SGAEGGCQAEVGSAAAMSAAALVKAAGGTSHQASQAIAFVIKNLLGLVCDPVAGLVEV
                     PCVKRNALGASFALVAADMALADIESQIPVDEVIDAMYQVGSAMPTAFRETAEGGLAA
                     TPTGRRYSVEIFGE"
     gene            complement(3671..4285)
                     /locus_tag="VHC05_001683"
     CDS             complement(3671..4285)
                     /locus_tag="VHC05_001683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011185103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase SLT domain-containing protein"
                     /protein_id="HEQ5402959.1"
                     /translation="MFKKENLKQRYFNFGLVALALTILAIIFAFSSKNDDTKSYAKKS
                     ESKMVTIDKAPKNNHAITKEESKEKAKSIASEPIPTVENSVAPTVTEEAPVVQQEETQ
                     TVQQVSSVAYNPNNVVLSNGNTAGIVGSQAAAQMAAATGVPQSTWEHIIAHESNGNPN
                     AANASGASGLFQTMPGWGSTATVEDQVNAALKAYSAQGLSAWGY"
BASE COUNT         1390 a          837 c          761 g         1408 t
ORIGIN      
        1 ctaataatca tgaaataatc tgttttacga aatacctaat catcaaaata tctgttgtaa
       61 tactagagaa agtgagtctc atgatcgtat gatttctaca gtaactaata aagtaatgac
      121 tcaactttta cgaactattt ttaaaaataa tgtgattata tttaaaatat acagatatca
      181 taaattaatc cattaacgca tgattggttt ttataaataa tatcatatga tgtcaaagga
      241 attgttgaat gtccctttct ttttatctta ataaaagatt cattagatgt actgacaagg
      301 ctgcccattt ttataagcca tgtcaatcat accaccacca aggcattctt ttccgtcata
      361 gaaaacaaca gcttgaccag gagtaatcgc gcgctgtggc tctgcaaaaa caacttctgc
      421 cttatctcct cgaacatgca ccgtcacctg tgaatcgggt tgacgatagc gaaatttagc
      481 agtacattca aatgtgaact cttctggcat ctcacgtgta aaatggatga ctgaggcgtc
      541 aagactattt gacattaggg cttcatggta gaaaccttga ccaacgtata aaatattttg
      601 cgacaaatct ttaccgacaa caaaccaagg ttgattatcc ccaccatgct gaccaccaat
      661 gcccagacca ccacgctgac caatagtata atacataaga ccggcatgtt ctcccatatc
      721 gcgaccatca atagtcatca tgcgaccttt ttgtgccggt aagtactggc tcaaaaactg
      781 tttgaaattc ttttcaccaa taaaacaaat acctgttgaa tctttctttt tagccgttgc
      841 aagccctgct cgctcagcaa tttctctaac ttctgacttt tgcaaatgac caagggggaa
      901 taaagtcttt tgtagttgtt cctgtgatag ttgacttaaa aagtaggttt ggtctttgcc
      961 attatcagct ccacgtaaca tgtgaaccgt accattttca tcacgcttga cttgagcata
     1021 gtgtcccgtt gctacataat ctgcacctaa agtcatggca tagtcaagga aagctttaaa
     1081 ttttatttcc ttattacaca tgacatcggg atttggagta cgacctgctc ggtattcggc
     1141 caagaaatat tcaaatactc tgtcccaata ttctttttca aaattgactg aatagtaagg
     1201 aataccgatt tgatcagcaa cggctgctac atctttgtaa tcttcagtag ctgtgcaaac
     1261 accaaattca tctgtatcgt cccagttttt catgaagaca ccaataacat cataaccttg
     1321 ctcctttaaa agtagagctg ttacagatga atcaacgcca ccactcatac caacgacaac
     1381 acgtatcttt gagttatctg tcataaaaaa ttctcccatc aataataaga tagaaaaaga
     1441 taatcatcat attatgaata ttatgattct ttttcttatc agttaacgta cgattgaagg
     1501 tcgtcgtttt caaaagtcga tttgaaggtc gattttgaag cgccatcagc gcaaacctta
     1561 ttataacaat tactgcgtag aatgccaatc attttattac tcaataattt tttattataa
     1621 aaataatttt ttataattat attgctgttt tttgatattt ttttgttata ataaacatag
     1681 aaataaaaaa cggagttgcc tatgaataca caaaaatttc aatcagtttt tgacatcatt
     1741 gggccagtaa tgattggtcc atcaagtagt cacacagctg gtgccgtcag aattggtaag
     1801 gtagtccatt ccatctttgg agatattcct gatgaagtga cgtttcacct ttataattca
     1861 tttgctaaaa cctacagagg acatggtact gataaggctc ttgttgcagg aattatgggt
     1921 atggatactg ataatcctga tattaaaaat tctctagaaa ttgctcatca aaaagggata
     1981 aaaatctatt gggatatctt aaaagatagt aatgctcccc atcccaatac tgttaaaatc
     2041 agtgtcaaaa aagctgacaa aacacttagt gttactggtg tttcaattgg aggaggaaac
     2101 attcaagtaa cagaactaaa tggtttttct gtctcgttat ccatgaatac tcctactata
     2161 gttactgtac acaaagatat tcctggaatg atcgcaaagg taactgatat cctatcttcc
     2221 aataatatta atatcgccac aatgaatgtt acacgtgaat ccgctggtga aaaagctact
     2281 atgattatag aagtcgattc tagagagtgc caagaagcag ccaaccaaat tgcaaaaatt
     2341 cctcatattt ataatgtcaa cttctttgac tagaaaggaa agctatgttt tatactattg
     2401 aagaacttgt caaacaagct gaccaacaat ttaatggaaa tattgctgaa ctcatgattg
     2461 ccacggaagt ggagatgtct ggaagaaatc gagaagatat tatcaaaatc atgtcacgca
     2521 atttacaagt tatgaaagca gctgtaacag aaggactaac ctcaaccaaa tctatcagtg
     2581 gtttgacagg gggcgatgcg gtcaaaatgg ataactacat taaaaaaggg aacagccttt
     2641 ctgatactac tattcttaat gctgttagaa atgctatagc tgtaaacgaa ttaaatgcta
     2701 aaatgggact tgtctgtgca acgcccactg caggaagtgc aggatgctta ccagcagtgc
     2761 tcgcaacagc tattgaaaaa cttgacttat cagaaaaaaa acaattagag tttttattta
     2821 ctgcaggagc ttttggtctt gttattggaa ataacgcctc tatttctggt gcagaaggtg
     2881 gatgccaagc agaagttggt tctgcagctg ctatgagtgc agctgctctt gttaaggcag
     2941 ctggtggaac atctcatcaa gctagtcaag ctattgcgtt tgttatcaaa aatttattag
     3001 gacttgtctg tgatcctgtt gccggcctag tagaagtgcc ttgtgtcaaa cgcaatgccc
     3061 taggagcaag tttcgccctt gtcgcagctg atatggcttt agctgatatt gaatctcaaa
     3121 ttcctgttga cgaagttatt gatgctatgt atcaagtcgg ctctgccatg ccaactgctt
     3181 tccgtgaaac agcagaaggt ggtttagccg ctactccaac tggacgacgt tacagcgtag
     3241 aaatatttgg cgaataaata gatagttaga aaaattctta gaaatatttg aaagcgtttt
     3301 atttttctgc tatatattca ctaaaatgac taatagatag ctatcaagct atgttgtttc
     3361 cccttagaaa caactcctag taaattgttg aaactcaaaa gtgtagtagt gtaaaatact
     3421 gaaaattgct aatgacctta taaacattta agagtttttt tcctgcttgt tatcagtata
     3481 actgccttaa atatcagagg cacttaagtg ctggtcagtt ttcctaaata atacgagcta
     3541 tattccctga taaggcaatg ttttgttttg agactaattc atcactacaa atcataaaga
     3601 caattaaata ccaaaaacct attgttagta aatactaaca ataggtttta tttcttccag
     3661 ctatgtttat ttagtaaccc caagctgata aaccttgtgc actataggct ttcaaggctg
     3721 cattgacttg atcttcaacc gttgctgtag aaccccaacc tggcattgtc tggaacaacc
     3781 ctgatgcccc agaagcatta gctgcgttag gatttccatt agattcatgc gcaattatat
     3841 gttcccaagt tgattgtgga acacctgttg ctgctgccat ctgtgccgcc gcttgacttc
     3901 ctacaatacc agcagtattt ccattagaaa gtaccacatt gtttggatta taggctactg
     3961 aagatacctg ctgaacagtt tgagtctctt cttgctgaac aaccggtgct tcctctgtta
     4021 ctgtcggagc tacagagttt tctactgtgg gaataggctc cgaagcaatg ctctttgctt
     4081 tttctttgct ttcttcttta gtaatagcat gattattttt tggagccttg tcgattgtta
     4141 ccattttact ttctgacttc ttagcataag acttagtatc atcattttta cttgagaagg
     4201 caaaaatgat ggctaatatt gttagagcta acgctactaa tccaaaatta aaataacgtt
     4261 gttttaaatt ttctttctta aacattcaat aatacctcac ttttctccgt tatccataat
     4321 atcttttaat tattacctcg ttattgaaga tatattaaaa atattacaac tacattgata
     4381 ttataagaag ttgtaa
//
LOCUS       DAUDWO010000070         4276 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.071, whole genome shotgun sequence.
ACCESSION   DAUDWO010000070 DAUDWO010000000
VERSION     DAUDWO010000070.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4276)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4276)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4276
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.071"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            189..1412
                     /locus_tag="VHC05_001684"
     CDS             189..1412
                     /locus_tag="VHC05_001684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HEQ5402960.1"
                     /translation="MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKA
                     TTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSSSLSNPYTKLFGEGRSKENKDAE
                     LSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
                     VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKN
                     ENGETVSTNAIQTDAAINPGNSGGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGI
                     GFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQINIPTSVTGGIVVA
                     EVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKA
                     DIKLTKTTQDLTKTQ"
     gene            1471..2277
                     /locus_tag="VHC05_001685"
     CDS             1471..2277
                     /locus_tag="VHC05_001685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HEQ5402961.1"
                     /translation="MFLIISRNSLMTKELLIDLPIEDIVTNPYQPRIQFNQRELQDLA
                     TSIKSNGLIQPIIVRKSDIFGYELVAGERRLKASKMAGLKKVPAIIKKISTLESMQQA
                     IVENLQRSNLNAIEEAKAYQLLVEKKHMTHDEIAKYMGKSRPYISNTLRLLQLPAPII
                     KAIEEGKISAGHARALLTLSDDKQQLYLTHKIQNEGLSVRQIEQLVTSTPSSKLSKKT
                     KNIFATYLEKQLAKSLGLSVNMKLTANHSGYLQISFSNDDELNRIINKLK"
     gene            2510..3865
                     /gene="dnaA"
                     /locus_tag="VHC05_001686"
     CDS             2510..3865
                     /gene="dnaA"
                     /locus_tag="VHC05_001686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012657571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="HEQ5402962.1"
                     /translation="MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLLKVDKHIATI
                     YLDQMKELFWEKNLKDVILTAGFEVYNAQISVDYVFEEDLMIEQNQTKINQKPKQQAL
                     NSLPTVTSDLNPKYSFENFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTH
                     LLNAIGNSVLLENPNARIKYITAENFINEFVIHIRLDTMDELKEKFRNLDLLLIDDIQ
                     SLAKKTLSGTQEEFFNTFNALHNNNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNI
                     TPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEGALKDISLVANFKQI
                     DTITVDIAAEAIRARKQDGPKMTVIPIEEIQTQVGKFYGVTVKEIKATKRTQNIVLAR
                     QVAMFLAREMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMISQDESLRIEIETIKNKI
                     K"
     gene            4020..>4276
                     /locus_tag="VHC05_001687"
     CDS             4020..>4276
                     /locus_tag="VHC05_001687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002981935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HEQ5402963.1"
                     /translation="MIQFSINRTLFIQALNATKRAISTKNAIPILSSIKIEVTPTGVT
                     LTGSNGQISIENTIPVSNENAGLLITSPGAILLEASFFINI"
BASE COUNT         1519 a          728 c          691 g         1338 t
ORIGIN      
        1 ttacttttta cacaatttat ccacaagtta tttttcttca actactaata aaaacctttg
       61 tacaaaggtc tttattagta aaaagaaaag taatccacag cctgtggatt acttttcttt
      121 tttttatttt taaggtataa ttaagcaaag ttctataagc tatggacaaa taattcggag
      181 gacaaaacat gccaagtatg aaacatatct taaaatcctt aagtatttta ctaattggat
      241 ttttaggagg attaatagca attattacat tcaataatct ctacccacat tctccttcaa
      301 aaataaattc aggtaaggca acaactagta atatggtttt taacaacaca accaatacta
      361 ctaaagctgt caaagctgtt caaaatgcag ttgtatcagt tattaattat caagataacc
      421 cttcttcatc cctttctaac ccttatacaa aactctttgg agaagggcgt tcaaaagaga
      481 ataaggatgc tgaattatct atttttagtg aaggatctgg ggtcatttat cgaaaagatg
      541 gcaactccgc ttacgttgtt actaataacc atgttatcga cggagctaaa cgaattgaaa
      601 ttcttatggc agacggatct aaagttgttg gtgaattagt tggagctgat acttattcgg
      661 atttagctgt tgttaagatc tcttcagata agataaaaac agtagctgaa tttgcagatt
      721 ctacaaaact aaatgttgga gaagttgcta ttgctatcgg cagcccacta ggaacacaat
      781 acgctaattc tgttactcaa ggaatcgtct ctagtttaag tcgtactgta actttaaaaa
      841 acgagaatgg tgagactgtc tcaacaaatg ctattcagac agatgctgct attaaccctg
      901 gaaactctgg tggaccacta attaatattg aggggcaagt aatcggaatt aattcaagta
      961 aaatttcttc taccccaact ggtagcaacg gtaatagtgg tgctgttgaa ggaattggtt
     1021 ttgctatccc atctactgat gttattaaaa ttattaaaca actagaaact aatggtgaag
     1081 ttatcagacc tgctcttgga atatccatgg tcaatttaaa tgacttatcc acaaatgctc
     1141 ttagccaaat taatattcca actagtgtaa ctggtggtat tgtagtagca gaagttaagg
     1201 aaggaatgcc ggcatctggc aaacttgctc agtacgatgt gattacagaa attgatggca
     1261 aaacagttaa ttcaattagt gatttacaaa gtagtctata cggacatgat attaatgata
     1321 ctattaaagt aactttttat agaggaacta caaagaaaaa agcagatatc aaattaacaa
     1381 aaactactca agatttgact aaaacgcagt aaacaagcta cctaaatact attacatttt
     1441 atcacataaa acagtccaaa ggactgtttt atgtttctta ttatatccag gaactccctt
     1501 atgacaaaag aattattgat agacctacca attgaagata ttgttacaaa tccctatcag
     1561 ccaaggatac aatttaatca aagagaactc caagacctag caacttctat taaatcaaac
     1621 ggcctcattc aacctattat tgttcgaaaa tctgacattt ttggctatga gttagttgct
     1681 ggagaacgac gacttaaagc ttcaaaaatg gctggtctaa aaaaagttcc agctatcatc
     1741 aagaagatct ctacactcga gagcatgcaa caagctatag ttgaaaattt acaacgttct
     1801 aaccttaacg ctatcgaaga agctaaagcc tatcagttat tggttgaaaa aaaacacatg
     1861 actcacgatg agattgctaa atatatggga aaatcaagac cttatattag caatacctta
     1921 cgtctgttac aactcccagc acctatcatt aaagcaattg aagaaggaaa aattagtgcg
     1981 ggacacgcgc gtgctctttt aactttgagt gatgataagc aacaactgta cctcactcat
     2041 aaaatacaaa atgaaggcct aagtgttagg caaattgagc aactggttac ttctactcca
     2101 agttcgaagc tatctaaaaa aactaaaaat atatttgcca cttatttaga gaaacaattg
     2161 gctaaatcat tgggactctc tgtcaatatg aagctgacag caaaccatag tgggtacctt
     2221 cagatatctt tttccaatga tgatgaatta aacagaatta tcaacaagct aaagtagctt
     2281 gttgatattc ttttttttct tttttagttt tccacatgaa aaatagttga aaacaatagc
     2341 ggtgtcacct taaaatgtct tttccacagg ttgtggagaa ctcaagttaa cagtgttaat
     2401 ttattttcca cagattgtgg aaaaactaac tattatccat tgttctgtgg aaaactagaa
     2461 tagtttatgg tagaatagtt ctagaattat ccacaagaag gaacctagta tgactgaaaa
     2521 tgaacaaatt ttttggaaca gggtcttgga attagctcag agtcaattaa aacaggcaac
     2581 ttatgaattt tttgttcatg atgcccgtct attaaaggtc gataagcata ttgcaactat
     2641 ttacttagat caaatgaaag aactcttttg ggaaaaaaat cttaaagatg ttattcttac
     2701 tgctggtttt gaagtttata acgctcaaat ttctgttgac tatgttttcg aagaagacct
     2761 aatgattgag caaaatcaga ccaaaatcaa tcaaaaacct aagcagcaag ccttaaattc
     2821 tttgcctact gttacttcag atttaaaccc gaaatatagt tttgaaaact ttattcaagg
     2881 agatgaaaat cgttgggctg ttgctgcttc aatagcagta gctaatactc ctggaactac
     2941 ctataatcct ttgtttattt ggggtggccc tgggcttgga aaaacccatt tattaaatgc
     3001 tattggtaat tctgtactat tagaaaatcc aaatgctcga attaaatata tcacagctga
     3061 aaactttatt aatgagtttg ttatccatat tcgccttgat accatggatg aattgaaaga
     3121 aaaatttcgt aatttagatt tactccttat tgatgatatc caatctttag ctaaaaaaac
     3181 gctctctgga acacaagaag agttctttaa tacttttaat gcacttcata ataataacaa
     3241 acaaattgtc ctaacaagcg accgtacacc agatcatctc aatgatttag aagatcgatt
     3301 agttactcgt tttaaatggg gattaacagt caatatcaca cctcctgatt ttgaaacacg
     3361 agtggctatt ttgacaaata aaattcaaga atataacttt atttttcctc aagataccat
     3421 tgagtatttg gctggtcaat ttgattctaa tgtcagagat ttagaaggtg ccttaaaaga
     3481 tattagtctg gttgctaatt tcaaacaaat tgacacgatt actgttgaca ttgctgccga
     3541 agctattcgc gccagaaagc aagatggacc taaaatgaca gttattccca tcgaagaaat
     3601 tcaaacgcaa gttggaaaat tttacggtgt taccgtcaaa gaaattaaag ctactaaacg
     3661 aacacaaaat attgttttag caagacaagt agctatgttt ttagcacgtg aaatgacaga
     3721 taacagtctt cctaaaattg gaaaagaatt tggtggcaga gaccattcaa cagtactcca
     3781 tgcctataat aaaatcaaaa acatgatcag ccaggacgaa agccttagga tcgaaattga
     3841 aaccataaaa aacaaaatta aataacatgt ggaaaagaat atcttttatg aaatagttat
     3901 ccacatgttg tgaacaacca tttagtcttg cattctctcg tttatttaga gttatccact
     3961 atatacacaa gacctactac tactacttat tattatactt attaaataaa ggagttctca
     4021 tgattcaatt ttcaattaat cgcacattat ttattcaggc tttaaatgca actaaacgtg
     4081 ctattagcac taaaaatgcc attcctattc tttcatcaat aaaaattgaa gtcactccta
     4141 ctggagtaac tttaacaggg tctaacggtc aaatatcaat tgaaaacact attcctgtaa
     4201 gtaatgaaaa tgctggtttg ctaattacct ctccaggagc tattttatta gaagctagtt
     4261 tttttattaa tattat
//
LOCUS       DAUDWO010000071         4180 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.072, whole genome shotgun sequence.
ACCESSION   DAUDWO010000071 DAUDWO010000000
VERSION     DAUDWO010000071.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4180)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4180)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4180
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.072"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            518..1867
                     /locus_tag="VHC05_001688"
     CDS             518..1867
                     /locus_tag="VHC05_001688"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="HEQ5402964.1"
                     /translation="MSHITFDYSKVLESFAGQHEIDFLQGQVTEADKLLREGTGPGSD
                     FLGWLDLPENYDKDEFARILTAAEKIKSDSEVLVVIGIGGSYLGAKAAIDFLNHHFAN
                     LQTAKERKAPQILYAGNSISSTYLADLVEYVQDKEFSVNVISKSGTTTEPAIAFRVFK
                     ELLVKKYGQEEANKRIYATTDKVKGAVKVEADANNWETFVVPDNVGGRFSVLTAVGLL
                     PIAASGADITALMEGANAARKDLSSDKISENIAYQYAAVRNVLYRKGYITEILANYEP
                     SLQYFGEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGYRNLFETVIRVDK
                     PRKNVIIPELAEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGGVPNMFVTLPAQDEF
                     TLGYTIYFFELAIAVSGYMNAVNPFDQPGVEAYKRNMFALLGKPGFEELSAELNARL"
     gene            complement(2216..3723)
                     /locus_tag="VHC05_001689"
                     /pseudo
     CDS             complement(2216..3723)
                     /locus_tag="VHC05_001689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986134.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
BASE COUNT         1388 a          724 c          824 g         1244 t
ORIGIN      
        1 aaaataatag ctctgccgta tgtaaaataa tgttcaatac atggcacaaa gcatcttttg
       61 gcgagctttt aaaagggctt gctttttaag tattcaaatg attgccattt ttagataatg
      121 agaataagta atgttaagaa gatagcatga gaaagtattt acaggtgatt ggggcttcaa
      181 ttgcctttgc gggtgtggct ttatgcattg atcatatgta tgatggggtt attacccgta
      241 ttgaaatgat aaaatcctta aaataagcta ttaaggtaaa gcggcctcag ggcctttttt
      301 catgatattt ttagggaata tgaaatccta ttttctctta aaaaaccact atgatgagaa
      361 tatgcttgca ttgacacatt ttttatgtct gaaaaaacga aaaccttttc aaaaaaccta
      421 gctttttcac aggtgaaaac cactaaaaac cattgaaata ttagatagaa aaggttatca
      481 tactaatgaa acttaaaatt ttaagggagt gaaactcatg tcacatatta catttgatta
      541 ttcaaaagtc ctcgagtcat ttgcgggaca acatgaaatt gattttttac aaggccaagt
      601 cacagaggcc gacaagttat tgcgtgaagg aactggacca ggttcagatt tcttgggctg
      661 gcttgatctt ccagaaaact atgataaaga tgaatttgca cgtatcttga ctgctgctga
      721 aaaaattaag tcagacagcg aagttcttgt ggtgatcggt attggtgggt cataccttgg
      781 tgccaaagct gctatcgatt tcttaaacca tcactttgct aacttgcaaa ctgccaaaga
      841 gcgcaaagcg ccacaaattc tttacgctgg aaactctatt tcatcaactt acttagcaga
      901 ccttgtagag tacgttcaag acaaagagtt ctcagtaaac gtgatttcta aatcaggaac
      961 aactactgag ccagcgattg ctttccgtgt cttcaaagaa cttttggtta aaaaatatgg
     1021 ccaagaagaa gctaacaagc gtatttacgc tacaacagac aaagtgaaag gtgctgttaa
     1081 ggtagaagct gacgctaaca actgggaaac atttgtggtg ccagacaacg ttggtggtcg
     1141 tttctcagtc ttgactgctg ttggtttgct tccaattgct gcatcaggtg cagatatcac
     1201 agctcttatg gaaggtgcaa atgcagcgcg taaagacctt tcttcagaca aaatctctga
     1261 aaacattgct taccaatacg ctgctgttcg taatgtgctt taccgtaaag gctacatcac
     1321 tgaaatcttg gctaactacg agccatctct tcaatacttt ggcgaatggt ggaaacaatt
     1381 agccggtgaa tcagaaggaa aagaccaaaa agggatttac ccaacttcag ctaacttctc
     1441 aacagactta cactcacttg gtcaatttat ccaagaaggt taccgtaacc tctttgaaac
     1501 agttattcgt gttgataaac ctcgtaaaaa tgttatcatt cctgaattag cagaagacct
     1561 agatggactt ggttaccttc aaggtaaaga cgttgatttc gttaacaaga aagctacaga
     1621 tggtgtgctt cttgcccaca cagatggcgg cgtgccaaac atgtttgtca ctcttccagc
     1681 tcaagacgaa tttactcttg gttacactat ttacttcttt gagcttgcta tcgctgtttc
     1741 aggctacatg aatgctgtta acccatttga tcagccaggt gttgaagctt acaaacgtaa
     1801 catgtttgcg cttcttggaa aaccaggttt tgaagaatta tcagcagagc ttaacgctcg
     1861 cctctaataa acagatagtc aaaaagactt cttccttgta caagagctta aaagttagcc
     1921 aagcaatcta agaattgggg tggcacttcc atcatcaagt ggatacaagg ttaagtaaaa
     1981 gcgataataa agtgcgcttc cagaacatgg gagcgcactt tattatgcca aatttcagat
     2041 aaaaccttca aaaaagggaa gaagatccta caagaggagt tgaaccgcta aaacagttcc
     2101 agtgctgttt ctaggcgaat agcaatggtt aaaaagagag cttatcaagg ttgcaagtga
     2161 caaccttaaa gaccccccta gactgtgaaa gtatctagga gggactgtca aaaaattaag
     2221 aaggaactct ccaaagttct tctaaacgtt tttggtagtg gttctggtgc aaggctaaga
     2281 tggttttgat taaatcttcg cgctgctgtt ggatacagtc caaactcaaa ccaaacaagc
     2341 gggtctcttt gggaaaaaca ccgagttctt ttaagaaagg caagagcttc tgactggtca
     2401 caaccagatc tacaggttta tcatagggat aaatattatc agataagata ttgacccgtg
     2461 acagttcaac tttgtaagaa gggatagttg aggtgatgaa attagctata acgttaccaa
     2521 cagtttcttg gctctcaata acagtaatat tgattggagc aatagagctt tccaagatct
     2581 gctcaaggta taaacacatc aagtgtaagt gaccagaact aatactgcct tgacggcctg
     2641 tgtcataaag ccaatctttg ataacggttt caagcttatc tagtagtagc atgttgcctt
     2701 gatattgatc aaaataataa ccatcaaagg taattaaagt ttgtagattg tagagagttc
     2761 ttttgaaaaa aggaattaag ttagggatat gctcatgaat atcggaatac tttccaacta
     2821 gtgcctgaag acgatggatt agtaaatgat aatcgggatc tttggtgatt aaatggtaaa
     2881 gttgttgtcg ctgatgactt gtccagtacc cactcaagaa ggagttatca gtcgttaaat
     2941 aaattaaaaa gagatagtca aaatcatcag acgaaaatgt gacacgagtt cgaggtgcta
     3001 gctcatccac ggcaatggtt ttgatattgt caaaaatagg caaggatttg agatgttcaa
     3061 aaagagctaa atgaggcaaa tgaacaggat agcgatggcg cttccaagtc aacatcaaca
     3121 gcacatcaaa aaacaagaag cgtctatcta aaaaggcaga aggttgtaag ttttttgtgc
     3181 tgcaaagata aaagcatgaa tcgtttcaat gtctgcaggt tgtatatcat ataatataat
     3241 gccgtactct ttatgtaaaa gagcaatcaa ataccgtatt ttaagttcat ctccgataac
     3301 agtattgtct acaatattta aaccaatgtc ttgtaaataa tgttttaatt tatgaataag
     3361 acgataagct tttgactggg atatcccttg ttttcgtgta taaacagcga ttgacttgtg
     3421 tttgggatta tctagtaata agaatgtcaa catttttaga gtatctgata aggcaaaaat
     3481 atcataaaaa aatgcttctc gcttatcatt taatacctca caataaatac gagatttaat
     3541 aagctcaata cgtaagtacc ctttaaataa ggcgttaaat tgtcgaagat actgctttat
     3601 ttttaaagca gtcaaagttg tttgagaaca agctgctgcc atcgtcagtt ctttttctgt
     3661 caacaaaata gccagtagga ttttctggtc aataatatcg gattccaaat aataatctaa
     3721 caatgtaatt tttctctcct taaattaaat tgtataatcc tatatattgt agcgaatcta
     3781 ccgtaaaagt caactaaaat caataggatt actaatatag tcacaataaa gatcatcaaa
     3841 aagcagcaaa cttcatcaat agattgattg atgcgtgttt ttagcccata attgagagag
     3901 ctaagaacac gcgggtgata tcatattttt gctgttgact ttttaaattt aaaaacctaa
     3961 ccagccggtt aactggtcag gtttaaacaa gggagggcac ctaagaagat aggtgcccag
     4021 gagatttatg aaaagggaaa acaaggggaa aacctattct cccaacggtt taggtaaacc
     4081 gctttttagg atgttttcat tctacgatag taaccttaaa gttttcttaa atgattcttt
     4141 agaatgcctt tatttttaat cttttttgag agagctagtt
//
LOCUS       DAUDWO010000072         4085 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.073, whole genome shotgun sequence.
ACCESSION   DAUDWO010000072 DAUDWO010000000
VERSION     DAUDWO010000072.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4085)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4085)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4085
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.073"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            21..116
                     /locus_tag="VHC05_001690"
     CDS             21..116
                     /locus_tag="VHC05_001690"
                     /inference="COORDINATES: protein motif:HMM:NF038244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system DWW-type pheromone"
                     /protein_id="HEQ5402965.1"
                     /translation="MLKKYKYYFIFAALLSFKVVQELSAVDWWRL"
     gene            163..1161
                     /gene="ruvB"
                     /locus_tag="VHC05_001691"
     CDS             163..1161
                     /gene="ruvB"
                     /locus_tag="VHC05_001691"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_023079556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HEQ5402966.1"
                     /translation="MARILDNNVMGNEEFSDRTLRPQYLHEYIGQDKVKEQFAIFIEA
                     AKRRDESLDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPAVEKAGDLVAILNELE
                     PGDILFIDEIHRMPMSVEEVLYSAMEDFYIDIMIGAGDTSRSIHLDLPPFTLIGATTR
                     AGMLSNPLRARFGITGHMEYYQEKDLTEIVERTATIFEIKIDHEAARKLACRSRGTPR
                     IANRLLKRVRDYAQIIGDGIITAQITDRALTMLDVDREGLDYIDQKILRTMIEMYQGG
                     PVGLGTLSVNIAEERNTVEEMYEPYLIQKGFLMRTRTGRVATQKAYRHLGYPYQNT"
     gene            1299..1736
                     /locus_tag="VHC05_001692"
     CDS             1299..1736
                     /locus_tag="VHC05_001692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight phosphotyrosine protein
                     phosphatase"
                     /protein_id="HEQ5402967.1"
                     /translation="MKKVCFVCLGNICRSPMAEFVMKSIVSSDVMMIESRATSDWEHG
                     KPIHSGTQSILKTYQINYDITKCSKQITITDFNTFDYIIGMDSDNVKNLKEMSQHQWD
                     SKIYLFREGGVPDPWYTNDFEETYQLVRKGCQDWLSRLMNKEY"
     gene            1760..2161
                     /locus_tag="VHC05_001693"
     CDS             1760..2161
                     /locus_tag="VHC05_001693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402968.1"
                     /translation="MIDMQDIVKKWSITRAKLEIVSVIVILVCAISVFSVRISNKTSL
                     TYDKGRMHYTGYVINHKMNGEGKLVYPNGDIYEGTFKNGLFEGKGTFTAKTGWLYNGE
                     FHKGQANGKGVLKAKNNKVYKGIFKQGIFQK"
     gene            2158..3933
                     /locus_tag="VHC05_001694"
     CDS             2158..3933
                     /locus_tag="VHC05_001694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyltransferase"
                     /protein_id="HEQ5402969.1"
                     /translation="MRIKWFSFVRVTGLLLVLLYHFFKNVFPGGFIGVDIFFTFSGYL
                     ITALLIDEYTKKESIDIIGFLKRRFYRIVPPLVLMILLTIPFTFLIKKDFIANIGSQI
                     TAVLGFTTNIYEILTGSSYESQFIPHLFVHTWSLAIEVHFYLLWGVFVWLLARRKETQ
                     KQLRGLLFLISLGIFAISFLSMFIRSFMTSNFSLIYFSSLSHSFPFFLGAMFATITGI
                     NETTVRFQKNVRLWPRQYVLAAMVGAFTLLLVLTVTLDFNHITTYLFGFALASLFASI
                     MIYAARVLHEQTPDVQEPKAITYIADISYGIYLFHWPFYIIFSQLMSHILAVILTVFF
                     SILFATVSYYIVEPLVQGRKPNLLGLEIDCSPYYKWIVGGALALALLTLGTCMIAPKV
                     GKFEKQLLVSSLQQAQSNMERTHTLAAGDANALSDVGIIGDSVALRSSAAFSKIMPQA
                     QLDAAVSRNFKEAFDLFNNQIKSKSLSKTVVLAVGVNSLDNYSQAVQSFIEALPKGHR
                     LVLVSPYNAKNASQVAEARDYGLKLSKKYKYVTIADWYKVAVEHPDIWYGSDGVHYSE
                     DSQGAELYVSTIQTAVEKSAKKPAK"
BASE COUNT         1250 a          634 c          844 g         1357 t
ORIGIN      
        1 ttattaagga gtttttatcc atgttaaaaa agtataagta ctattttata ttcgcagctc
       61 tactatcttt taaagtagtt caagagctta gtgctgttga ctggtggcga ttataataaa
      121 agtaggacac tgctctcttt tactttatgt tataatagtc ctatggctag aattttagac
      181 aataatgtaa tgggaaatga ggagttttcg gatcggactc ttcgccctca atatctacac
      241 gaatatattg gacaagataa agttaaggaa caattcgcaa tttttataga agcagctaaa
      301 agacgtgacg aatctttaga ccatgtttta ttatttggac ctccaggact gggaaaaaca
      361 acaatggcat ttgtgattgc caatgaattg ggagttaatt taaagcaaac ttcaggtcct
      421 gccgttgaga aagctggaga tttggtagct attttaaatg aattagaacc aggggatatt
      481 ttgtttattg atgaaattca ccgcatgcca atgtctgtcg aggaagtact atatagtgct
      541 atggaagact tctatattga tattatgatt ggcgctggag atactagtcg tagtattcat
      601 ttggatctgc ctccatttac attgattggt gctactacac gtgcaggcat gttatctaat
      661 cccctcagag ctcgttttgg tatcactggt cacatggaat actatcaaga aaaggatttg
      721 acagagattg tggagcgtac agctactatt tttgaaataa aaatagacca tgaagctgca
      781 cggaaattag cttgtcgcag tagaggaacg ccccgcattg ctaatcgatt actaaaacga
      841 gtgcgtgact atgctcaaat tattggtgat ggcatcataa cggctcaaat aactgataga
      901 gctttgacta tgttagatgt tgaccgcgaa ggtctcgatt acattgatca gaaaatttta
      961 cgaacgatga ttgagatgta tcagggagga ccagttggtt tggggacatt atctgtgaat
     1021 attgccgagg agcgtaatac agttgaagag atgtatgaac cctacttaat tcaaaaaggc
     1081 tttctcatgc gaacacgaac aggtcgtgta gcgacgcaaa aggcttatcg tcatcttggc
     1141 tatccctatc aaaacactta atgatttttc aaatctaaga aaattaatct gaacctgctt
     1201 tttgtgttcg gattttttga taagttgaca gaaaattatt agattgattt ctccgatatc
     1261 agttagaaat ttgatataat aattcaaagg agtatttaat gaaaaaagta tgttttgtct
     1321 gtctgggtaa tatttgtcga agccccatgg ctgagtttgt aatgaagtca atagtatcaa
     1381 gtgatgttat gatgatagaa agtcgtgcta cttctgattg ggagcatgga aaacctattc
     1441 actcaggtac acagtccata ttaaaaactt accaaattaa ttatgatata actaaatgct
     1501 ccaagcagat aactataact gattttaaca cctttgacta tattattggt atggatagcg
     1561 ataatgtgaa aaatctcaaa gagatgtcgc aacatcaatg ggactctaaa atctatctgt
     1621 ttagagaagg gggtgttcct gatccttggt acactaacga ttttgaagaa acctaccaat
     1681 tagttagaaa aggatgccag gattggcttt ctcgtttaat gaataaagag tattgataat
     1741 tagaagttga gtaaaagaaa tgatagatat gcaagatata gtaaaaaaat ggagtattac
     1801 acgggcgaag ttggaaattg tctcggtgat tgtcatattg gtttgtgcaa tttctgtttt
     1861 tagcgtaaga atttcgaata agacaagttt gacctatgat aaagggcgta tgcactatac
     1921 tggttacgtg attaaccata aaatgaatgg agaagggaag cttgtctacc ccaacggtga
     1981 tatctatgag ggtactttta agaatggcct atttgaagga aaaggaactt ttactgctaa
     2041 gacgggctgg ttatataacg gggagtttca taaaggacaa gcaaatggca aaggtgtgtt
     2101 aaaagcaaag aataataaag tctataaagg gatttttaaa caggggatat ttcaaaaatg
     2161 agaataaaat ggttttcgtt tgttagggta acaggacttt tactggtttt actctaccac
     2221 ttttttaaaa atgtatttcc aggaggtttt attggtgttg acattttctt caccttttca
     2281 ggatatctaa tcacagccct cttgattgat gaatacacaa aaaaagagtc tatcgatatt
     2341 atcggttttt taaaaagacg cttttatcga attgttcctc ctttggtgtt aatgatttta
     2401 ttgaccattc cttttacgtt tttaattaag aaggatttca ttgctaatat aggaagtcag
     2461 attacagctg ttttaggatt taccactaat atttatgaaa tattgacggg aagtagttat
     2521 gaaagccaat ttattccaca tctctttgtt catacgtgga gcttagctat tgaagttcat
     2581 ttttacttgt tgtggggtgt atttgtttgg ttattagcta gacgcaagga gactcagaaa
     2641 caactgagag gactactgtt tttgatttct ttgggaatat ttgctattag tttcttgagc
     2701 atgtttataa gatcttttat gacctcaaat ttttccctga tttatttttc gagtctttct
     2761 cacagttttc ccttcttttt aggggcgatg tttgccacga taacaggtat taacgagact
     2821 actgttcgat ttcaaaaaaa tgtacgttta tggccgcgcc agtatgtcct tgctgctatg
     2881 gttggagcat ttacactttt gcttgtgcta acggtcacat tggattttaa ccatattacg
     2941 acctatctat ttggctttgc tttggctagc ttattcgcat caattatgat ttatgcagcg
     3001 cgtgttcttc atgagcaaac accagatgta caagagccta aagctatcac ttatatagct
     3061 gatattagct atgggattta cctcttccat tggccatttt acattatttt tagccaatta
     3121 atgtctcata ttttggcagt tattctaaca gttttctttt caatcttgtt tgccactgtg
     3181 tcttactata ttgtggaacc tttggtccaa gggagaaaac caaacctgct tggtttagaa
     3241 attgactgtt ctccttacta taagtggatt gtaggagggg ctctcgcctt agcattatta
     3301 actttaggaa cttgtatgat agcgcctaaa gttggtaagt ttgagaaaca attgttggtc
     3361 agttccctac aacaggctca aagtaatatg gagcggacac atacactagc tgcaggagac
     3421 gctaatgctt tgagtgacgt aggtattatt ggtgattctg tagcattacg ctctagtgcg
     3481 gcattctcaa aaattatgcc acaagcgcaa ctggatgcag cggtcagtcg gaattttaaa
     3541 gaagctttcg atttatttaa taaccaaatt aagtctaaga gtctatctaa gactgttgtc
     3601 ttagcagtag gtgttaactc gcttgacaac tattctcaag cagttcagtc ttttattgag
     3661 gcattgccaa aaggtcatcg tttagttttg gtttctccat ataatgccaa aaatgccagt
     3721 caggttgcag aagctagaga ctatggtctt aaattgtcca aaaaatacaa gtatgtcact
     3781 attgcagact ggtataaagt tgctgttgaa catccagata tttggtatgg cagtgacggt
     3841 gttcattata gtgaagatag tcaaggagca gaactatatg tctccacaat ccagactgct
     3901 gttgagaagt cagctaaaaa accagctaaa taaagttaag aaatgtctaa gagataagtc
     3961 agatccattg tgctctggct ttttcttgtg aacaaatgat gatggtaaaa tagtagtact
     4021 ttgaggtttt taaaagaaag cggtttcaga aataaaacgg ctttttttag atatatttct
     4081 gaaaa
//
LOCUS       DAUDWO010000073         3242 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.074, whole genome shotgun sequence.
ACCESSION   DAUDWO010000073 DAUDWO010000000
VERSION     DAUDWO010000073.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3242)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3242)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3242
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.074"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            91..1509
                     /locus_tag="VHC05_001695"
     CDS             91..1509
                     /locus_tag="VHC05_001695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C69 family dipeptidase"
                     /protein_id="HEQ5402970.1"
                     /translation="MDKKIQRFSCTTILVGKKASYDGSTMVARTEDSQNGDFTPKKMI
                     VVKPEDQPRHYRSVQSSFEMDLPDNPMTYTSVPDALGEDGIWAEAGVNEANVAMSATE
                     TITTNSRVLGADPLVASGIGEEDMVTLVLPYIRSAREGVLRLGAILEDYGTYESNGVA
                     FSDKHDIWWLETIGGHHWIARRVPDDAYVTNPNQFGIDHFEFNNPEDYLCSADLKDFI
                     DTYHLDLTYSHEHFNPRYAFGSQRDKDRHYNTPRAWIMQKFLNPEIVQDPRSFALAWC
                     QKPYRKITVEDVKYVLSSHYQDTVYDPYGSEGTPVSKKIFRPIGINRTSQTAILHIRP
                     NKPQEIAAIQWMAYGSMPFNTMVPFFTQVKTIPDYFANTYENVSTDNFYWTNRLIAAL
                     ADPHYNHHETDLDNYLEETMAKGHAMLHAVEAQLLAGETVDLEEENQKMSDYVQGETQ
                     TLLNKILFDASNLMTNRFSLSD"
     gene            1661..3208
                     /locus_tag="VHC05_001696"
     CDS             1661..3208
                     /locus_tag="VHC05_001696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ABC transporter substrate-binding protein
                     AdcA"
                     /protein_id="HEQ5402971.1"
                     /translation="MKKKILLMMSLISVFFAWQLTQAKQVLAEGKVKVVTTFYPVYEF
                     TKGIVGNDGDVSMLMKAGTEPHDFEPSTKDIKKIQDADAFVYMDDNMETWVSDVKKSL
                     TSKKVTIVKGTGNMLLVAGAGHDHHHEEADKKHEHNKHSEEGHNHAFDPHVWLSPYRS
                     ITVVENIRDSLSKAYPEKAESFKANAATYIEKLKELDKDYTAALSDAKQKSFVTQHAA
                     FGYMALDYGLNQISINGVTPDAEPSAKRIATLSKYVKKYGIKYIYFEENASSKVAKTL
                     AKEAGVKAAVLSPLEGLTEKEMKAGQDYFTVMRKNLETLRLTTDVAGKEILPEKDTTK
                     TVYNGYFKDKEVKDRQLSDWSGSWQSVYPYLQDGTLDQVWDYKAKKSKGKMTAAEYKD
                     YYTTGYKTDVEQIKINGKKKTMTFVRNGEKKTFTYTYAGKEILTYPKGNRGVRFMFEA
                     KEPNAGEFKYVQFSDHAIAPEKAEHFHLYWGGDSQEKLHKELEHWPTYYGSDLSGREI
                     AQEINAH"
BASE COUNT         1072 a          610 c          679 g          881 t
ORIGIN      
        1 aagataagga ggtgctgctg gaattatgaa aatttttgta tccagttcaa tggatatttg
       61 atataatcgt cttaaaaagg aggtcgtgaa atggataaaa aaatacagcg tttttcatgt
      121 acaactatac tcgtcggtaa aaaggcatct tatgatggct caaccatggt tgctcgaaca
      181 gaagattctc aaaatggaga tttcacgcct aaaaaaatga ttgtggtgaa accagaagat
      241 caaccgagac attaccgttc ggtgcaatct tcctttgaaa tggacttacc ggacaatccc
      301 atgacttaca cgtctgttcc cgatgcgctt ggtgaagatg gtatctgggc agaagcaggc
      361 gtgaacgagg ctaatgtggc catgtcagca actgaaacca tcactaccaa ttctcgtgtt
      421 ttaggggcag atcctctagt agcttctggt attggtgagg aggacatggt aaccttagtg
      481 cttccttata tccgttctgc gcgtgaaggg gttttgcgcc ttggtgccat tttagaagac
      541 tatggcactt acgagtcaaa tggtgtggct ttttcagata aacatgacat ttggtggctg
      601 gaaacgattg gtggtcatca ttggattgca agacgggtgc cagatgatgc ttatgtcacc
      661 aatcccaatc aatttggcat tgatcatttt gaatttaaca atcctgaaga ttacctttgc
      721 tcagctgatt taaaggactt tattgacacg tatcacttag atttaaccta tagccatgag
      781 cattttaatc cgcgttatgc ctttggtagt caacgtgaca aagaccgtca ctataatacg
      841 ccacgtgctt ggatcatgca aaaattctta aacccagaaa ttgtgcaaga cccgcgcagc
      901 tttgcccttg cttggtgtca aaaaccttac cgtaaaataa cagtagaaga tgtcaaatat
      961 gtattgagta gtcactatca ggacacggtt tatgaccctt acggttcaga aggaactcct
     1021 gttagtaaga aaatctttcg ccctattggc attaaccgta ccagccaaac cgctatctta
     1081 catattcgtc ctaataaacc tcaagaaatt gcggctatcc agtggatggc ttatgggtca
     1141 atgcctttta ataccatggt gccttttttc acacaggtga agactattcc agattatttt
     1201 gccaacactt acgaaaatgt gtctaccgac aatttctatt ggaccaaccg tctgattgcg
     1261 gctttggcag atcctcacta caatcatcat gaaactgatt tggacaatta cttggaagaa
     1321 accatggcaa aaggtcatgc catgttacat gctgtggaag cacagttatt ggctggtgaa
     1381 acagtcgatt tggaagagga aaatcaaaag atgagtgact atgtgcaagg agaaacgcag
     1441 acgctgttga acaagattct ctttgacgct agcaatctaa tgaccaatcg tttcagtttg
     1501 agcgattaat agtgaagcta aggctgagca actgcttagc cttttttacg ataacttttt
     1561 aggaaaagta atcgcaaaaa gacaaaaact tggaaaaaaa atcaaagtat gctatactta
     1621 actggtcaat ttttaaccag ttaataacaa aggaggaatc atgaaaaaga aaattctttt
     1681 aatgatgagt ttaatcagtg tcttttttgc ttggcaactt actcaggcaa aacaagtctt
     1741 agcagagggt aaagtgaagg tggtgacaac tttctatcct gtttatgaat ttacaaaagg
     1801 gattgttggt aatgatggcg atgtttccat gcttatgaaa gcaggaacgg aacctcatga
     1861 ttttgagcct tctacaaaag acattaaaaa aatccaagat gcagatgcat ttgtttatat
     1921 ggatgacaat atggaaactt gggtttctga tgtgaaaaaa tcattgacat ctaaaaaagt
     1981 gaccatcgtt aagggaactg gtaacatgct cttggtagca ggagctggac atgaccatca
     2041 ccatgaggaa gctgacaaaa agcatgagca taataaacat agcgaagaag gacacaacca
     2101 tgcttttgac ccacacgtgt ggttgtcacc ataccgtagc attacggtcg ttgaaaatat
     2161 tcgcgacagt ctttcaaaag cttacccaga aaaagcagag agcttcaaag ccaatgccgc
     2221 tacttatatt gaaaaattaa aagagcttga caaagactat acggcagcac tttcagatgc
     2281 taagcaaaag agctttgtga cacaacacgc agcttttggt tatatggcac ttgactatgg
     2341 cttgaaccaa atttctatta atggtgtcac accagatgca gaaccatcag caaaacgtat
     2401 tgctactttg tcaaaatatg ttaaaaaata tggtatcaaa tacatttatt ttgaggaaaa
     2461 tgcgtcaagt aaagtcgcaa aaaccctagc taaagaagca ggagttaaag cggctgtgct
     2521 tagtccgctt gaaggtttga ctgaaaaaga gatgaaagct ggccaagatt actttacggt
     2581 catgcgtaaa aaccttgaaa ccttacgctt aaccactgat gtggctggta aagaaattct
     2641 tccagaaaaa gacacgacta agacagttta caatggttat ttcaaagaca aagaagtcaa
     2701 agatcgtcaa ttatctgact ggtcaggtag ctggcaatct gtttacccct atctacaaga
     2761 tggtacttta gaccaagttt gggactacaa ggctaaaaaa tctaaaggta aaatgacagc
     2821 agccgagtac aaagattact acactactgg ttataaaact gacgtggaac aaatcaaaat
     2881 caatggtaag aaaaagacca tgacctttgt tcgtaatggt gaaaagaaaa ccttcactta
     2941 cacatacgcc ggcaaagaaa tcttgaccta tccaaaagga aatcgtggag ttcgtttcat
     3001 gtttgaagct aaagaaccaa atgctggcga attcaaatac gttcaattta gtgaccatgc
     3061 cattgctcct gaaaaagcag agcatttcca cctgtactgg ggtggtgaca gccaagaaaa
     3121 attacataaa gagttagaac attggccgac ttactacggt tcagacttat ctggtcgtga
     3181 aatcgcccaa gaaatcaatg ctcattaatg ctaaaaaagc aaacctaaga aagattaggt
     3241 tt
//
LOCUS       DAUDWO010000074         3237 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.075, whole genome shotgun sequence.
ACCESSION   DAUDWO010000074 DAUDWO010000000
VERSION     DAUDWO010000074.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3237)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3237)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3237
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.075"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(154..336)
                     /locus_tag="VHC05_001697"
     CDS             complement(154..336)
                     /locus_tag="VHC05_001697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class IIb bacteriocin, lactobin A/cerein 7B
                     family"
                     /protein_id="HEQ5402972.1"
                     /translation="MDNFLELQFEELVNISGGKGNIGSAIGGCLGGMLIAAAGGPITG
                     GAAAFVCVASGIAAYQ"
     gene            complement(351..596)
                     /locus_tag="VHC05_001698"
     CDS             complement(351..596)
                     /locus_tag="VHC05_001698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Blp family class II bacteriocin"
                     /protein_id="HEQ5402973.1"
                     /translation="MIKFAEEIQKEELFHIIGGYSATDCKNHLIDGITSGAIAGGVGA
                     GMATLGVGGVAGAFAGAHVGAIAGGLTCVGGMLFNGK"
     gene            complement(784..1470)
                     /locus_tag="VHC05_001699"
                     /pseudo
     CDS             complement(784..1470)
                     /locus_tag="VHC05_001699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191693.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            1924..>3237
                     /locus_tag="VHC05_001700"
     CDS             1924..>3237
                     /locus_tag="VHC05_001700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_125458604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="HEQ5402974.1"
                     /translation="MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKT
                     NKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDVPYPFIVHVNKEGKFQHYYVVYQ
                     NKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLINFLPL
                     IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYIL
                     QQMMSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTGEIISRFTDANAII
                     DALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIVIIFIFMHPFEKMNN
                     DVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQS
                     SLKQGAQLILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPL"
BASE COUNT         1028 a          629 c          480 g         1100 t
ORIGIN      
        1 taatattatt aatttgtaat agtacttagt aagacataaa caaatatcac aattaaaatt
       61 actttacttg cattttctct tacctcttta tccttcaaaa aaatttggga aagtattaga
      121 caaattaaac cgagtattat aactataatc atatcattga taagctgcaa ttccagatgc
      181 tacacataca aatgctgccg cacctccagt tattggacct cctgctgcag ctataagcat
      241 cccacctaag caccctccga tagcagatcc aatatttcct tttccaccag aaatatttac
      301 taattcttca aactgtaatt ctaaaaaatt atccattttt cacctcaaaa ttattttcca
      361 ttaaataaca taccaccaac gcaagttaat ccacccgcaa tagcacctac atgtgcacct
      421 gcaaacgcac ctgcaactcc tccaacacct aaagtagcca tacctgctcc aacaccacct
      481 gcaatagcac ctgaagtaat accatcaatt aaatgatttt tacaatctgt agcactataa
      541 cctccaataa tatggaacaa ctcttctttt tgtatttctt ctgcaaattt tatcataact
      601 ttaaaaacct ttctaaaatg ttatattcat cttgttgcaa ctttgacaaa ctaaatatag
      661 catattatta taaaaatttt tttctatgtc gtgaatggtt gtataaacat ctcaaataaa
      721 ctttttaaca tattagagac tgtcaataat gttgtgtaaa cacaagagta gagtttttga
      781 atattagtca aataagctat caagtgtgtc aaaacatact ccgaatcctt tatgaatacg
      841 agctccgaac ttaatattat aatcttcgaa aatacttaca agacatcgtt ctaaggcttc
      901 ttcatttgga aaaaccaccc tccttcttgc tttgtcgctt aatttcttta ttgagtgatt
      961 caatcaagtt tgtagagtaa atactagacc aaatgtaatg tggaaattga tagaaagtta
     1021 ggagattttc cgttgtttca agtgatgtca taaccttttt gtaacgaggc ttccactcag
     1081 aaacaagtgg tgaccataca tgcgctcaat aatgtcactg atttcgcgtg tcgtaacgcc
     1141 agtctgatag agtttgatca ccatctcttc caagtggtca tctcgtctag cataagatgg
     1201 taataaaact ggtgaaaact cgccgtttcg atctcttggg atgattaaat tgactaagcc
     1261 atactttgtt tcaaactgac gagaataagt cccattacgg ctattacctg tgttgtaacc
     1321 ttctttttca taaggttcat aaccaagaaa agctgatagt tcaacttgca agaggtcatt
     1381 catagctatt tctaaagagg agcgaaaaaa ttcatcaata tcttgttttt gtgctaggaa
     1441 gttaagtaat tctgtggtaa actgagtcat gggaataaat ctctttctag tgaagtgtcg
     1501 caactctact atacaggatt tattcctttt tgtgtgttta cacaagatat tttacactac
     1561 ccaattacca ccctcaacct tggcaagctt ttctatagtc atttggtgaa atgtttccag
     1621 tttctttatc tccatatcga ataacttctt ttcataattc ttaaatttgt ctcgttgcaa
     1681 cctcgagcta gtacagaata tcataaagaa cagtatcatg gcttcaaaat cttaaaaggc
     1741 cgttttttca tcatgaaatg tctttttatc ctctctacac ttacgctgtg acaatagtta
     1801 attaattaag aagtttaaat gataccattc atgcttttat aaataccttt taagattttt
     1861 gataaaaact ccctatatat atgtcataat agcttagtat ttagatagaa aggtctttta
     1921 caaatgatat cctatcgaaa aacatttgtt gctcagattg atgctagaga ctgtggtgtg
     1981 gctgctcttg cttccatcgc taaatattac ggttcagact actctttagc tcatttaaga
     2041 gagttagcta aaacaaataa agagggaaca acagcgcttg gcatcgtcaa agctgccaaa
     2101 ttaatggggt ttgaaacaag agctattcaa gcagacatga ccctctttga tatagaagat
     2161 gtcccttatc cttttattgt tcatgttaat aaagaaggta aattccaaca ctactatgtc
     2221 gtctatcaaa acaaaaaaaa ttatctgata atcggcgacc ctgacccgac agtaaaagtc
     2281 actaagatga caaaggagcg atttacttct gaatggacgg gtgtcgctat ttttctagca
     2341 cccgagccca gctacaagcc tcataaggac aaaaagaacg gtctaataaa ctttttacct
     2401 cttattttta aacagcgatc tctgattttc tatatcatat tagctagcct actcgttact
     2461 ctgattaata ttgtaggttc ttattaccta caaggtatat tagatgacta tattccaaat
     2521 caactgaaat caacactcgg cattatttca attggtctta tcattaccta tatcctccaa
     2581 cagatgatga gtttttcgcg agattatctc ctgactgtac tgagtcagcg attaagcatt
     2641 gacgtcattt tatcttacat tcgccatatt tttgaattac ccatgtcttt ttttgcaact
     2701 cgcagaacag gagaaatcat ttcacggttt acagatgcta atgctattat tgatgcactc
     2761 gcttctacta ttttgtctct ttttcttgat gtcagtattt taactatcgt agggacagtc
     2821 ctgttagtgc aaaataccaa tctttttctt ctatctctgg tttcagtccc tctatatatt
     2881 gttattatct ttatatttat gcacccattt gaaaagatga ataatgatgt catgcagagt
     2941 aactctatgg ttagctcagc cattatcgaa gatatcaatg gcattgaaac tattaaatca
     3001 ctgaccagtg aagaaaatcg ttatcagaaa attgatagtg aatttgtgga ctatctggat
     3061 aaatctttca agttaagtaa gtactctatt ttacaaagca gtctcaaaca aggggcgcaa
     3121 ctaatcctta acgtgatagt cttatggttt ggggccaaat tagttatggg aggaaaaatt
     3181 tctgttggtc agttgattac gtttaatact ctcttatctt attttaccaa tccttta
//
LOCUS       DAUDWO010000075         2895 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.076, whole genome shotgun sequence.
ACCESSION   DAUDWO010000075 DAUDWO010000000
VERSION     DAUDWO010000075.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2895)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2895)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2895
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.076"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            384..1379
                     /locus_tag="VHC05_001701"
                     /pseudo
     CDS             384..1379
                     /locus_tag="VHC05_001701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057759.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
     gene            1360..2640
                     /locus_tag="VHC05_001702"
     CDS             1360..2640
                     /locus_tag="VHC05_001702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LlaJI family restriction endonuclease"
                     /protein_id="HEQ5402975.1"
                     /translation="MLTVPNKSLLDMCRVATNMEGDTFVGIKAEIIEGVQEVTVNFPL
                     GFEIAKDVETARRDIIALVSVLQAHNDEESRLRTVNVNQALKTLNFPMEAYTFVIHDF
                     INRGTYYKETEEYYIQTLGGRINWARTIKRVQPVVQGNGFKFLKMESKKQSDTDITLL
                     TEINKFCVYEAFLNMGWLYQLPQPEKARINYNRSQFESIIKKKMATTFNDMERRLFQS
                     MIDILNYKDRQEEPDKFYFGTNNFQYIWENLIDYTYGIANKTSYFPRTKWDLVFETKT
                     SKGYALEPDTIMVHNDNVFVLDAKYYKFGQTNLMKDLPPSTSINKQITYGEYVANQDL
                     LKKLHGQNSKVYNAFLMPFSKSHEIFQTDGMYQYIGEALGEWKGQDKTYERVQGILVD
                     VKTLVHNSARNRTQYIQELSDLISEKVDEKLANM"
     gene            complement(2662..>2895)
                     /locus_tag="VHC05_001703"
     CDS             complement(2662..>2895)
                     /locus_tag="VHC05_001703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="HEQ5402976.1"
                     /translation="NLDTLLPDWNLPDLISAFYFTLFYSNPKIAMYKICENIGCNTPF
                     YVQRSNTIKKYCSESCKNASSQRRYRNKQKDFQ"
BASE COUNT         1020 a          394 c          548 g          933 t
ORIGIN      
        1 ataaatcaat cctgttggac acactatcgg gcgatgattt taaagaattt tgccaaacag
       61 ctagaaatgg tgaattagat gaaaatttat ttgatactat ctcagtagat cttactgaaa
      121 ctgatacgtt atttctaaag aaatttgtta ccgattatca ttggtggcat ggcgggaagg
      181 aaatccacag gggggatagt tttatatcac caattttagc tttattaaag ttaattaatg
      241 cttcttctga acatgtagca ataattgtaa agtatctcgt tgatgcagat tttgatttaa
      301 gtgatgtaaa taagtacttt gaacttgttg aaatggacag ccgaagtgta gttactacca
      361 attatgacaa tacgaacctt gtgggtgata atattcttct ctatggggtt cctgggtctg
      421 gaaaaagttt taaaattgct accgaatatt gcaatgatga aaatagaatg gagcgattag
      481 tctttcatcc ggactatatg aatactgact ttgtcggaca aataatgcct actgtaaaag
      541 aaaatggaga tattacctat cttttttcac ctggaccttt tacaagaatt gtgaaaaagg
      601 caattgataa ccctagtgaa cactattatc ttgtaattga ggagttaaat cgaggcaatg
      661 ctcccggaat atttggagaa atctttcaat tattggatag aagtgctagc ggtgaaagcg
      721 tctacggtat taacaattca atacttgcta cggaaattta tggtgataag tctcatcaaa
      781 ttaaaatccc ttctaactta tcgttacttg caacaatgaa taccgcagac caaaatgtat
      841 tcactcttga tacagcattt caacgtcgat ggacaatgga aatgattgaa aatgatgttg
      901 atttatcgga atatgggaat tattttattg ctgatacaca atattcttgg aaagtattca
      961 acaaagttat caataaaaaa attcttgaga ctagtagcca gactctaact tcagaagata
     1021 agcgaatggg agcatatttt atttctggta atgtattgaa tattgaacgg atacatcaag
     1081 taccagcagg tgattccggt aatgaattca ataaaaaaaa taaacgcttt gcagaaaaag
     1141 ttttgaaata tctttgggat gatgccttca agtttaatcg tgaagatatc tttgatgttg
     1201 ctttgtatcc aagtttagag gcaattatta agcgattcac ggataatgat aatcctgaaa
     1261 atgggcgttt tgatgttttc gccaaagata tcaaagagga gttagaaaat cttaaggaag
     1321 caactttaat agataataac aacgacacag gagaagaaga tgttgacagt accgaataaa
     1381 tccttactgg atatgtgtcg tgttgcaaca aatatggaag gtgatacgtt tgttggtatt
     1441 aaagctgaga taatagaagg tgtacaagaa gttactgtaa attttccatt agggtttgag
     1501 attgcaaaag atgtagaaac agcaagaaga gacataattg cccttgtttc cgtcttacaa
     1561 gctcataatg atgaagagtc tcgcctaaga actgtaaacg tgaatcaagc tctaaaaacg
     1621 ttaaactttc ctatggaggc ttatacattt gttatacatg attttattaa tcgtggtaca
     1681 tattacaagg agactgaaga gtactatatt caaactttgg gtggccgaat taattgggcg
     1741 agaactataa aacgtgttca accagttgtt caaggaaatg gatttaaatt tttgaaaatg
     1801 gaatctaaga agcaaagtga tactgatatt actcttttaa cggaaataaa caaattctgt
     1861 gtatatgaag cttttctaaa tatgggatgg ctgtatcagc ttcctcaacc tgaaaaagct
     1921 cgtattaatt ataatagatc tcagtttgag tctataatca aaaaaaagat ggctacaact
     1981 tttaatgata tggagagaag acttttccaa agtatgattg acatacttaa ttataaggat
     2041 aggcaagagg aacctgataa gttttatttt ggaactaata atttccaata tatctgggaa
     2101 aatcttatag attatacata tggaattgcc aataaaactt catattttcc tagaacaaaa
     2161 tgggatttag tttttgagac aaaaacttca aaagggtatg cattagaacc ggatactatt
     2221 atggttcata atgacaatgt ttttgtatta gatgcaaaat attacaagtt tggtcaaact
     2281 aacttaatga aagatttgcc tccttctaca agtattaata agcaaattac atatggtgag
     2341 tatgtggcaa atcaagattt gcttaaaaaa ttacatggac agaattcaaa agtttataat
     2401 gcattcttaa tgccattttc aaagagtcac gaaatttttc aaacagatgg aatgtatcag
     2461 tatatcggag aagctcttgg tgagtggaag ggtcaggata aaacttatga gcgagttcaa
     2521 ggtattttag tcgatgtaaa aactttggta cataattctg ctagaaatcg gactcagtat
     2581 atccaagaat tatccgattt aatctccgag aaggttgatg aaaaattagc aaatatgtaa
     2641 taagactttc agtgataatt ttcactgaaa gtctttttgt ttatttctat atcttctctg
     2701 agaagaagcg ttcttacaac tttcagagca atattttttt attgtatttg acctttggac
     2761 ataaaatggg gtgttacatc ctatattctc gcaaatttta tacatggcaa ttttaggatt
     2821 tgagtaaaat aaagtgaagt aaaatgctga aattaaatct ggtaaattcc aatcaggtag
     2881 taaagtatct aaatt
//
LOCUS       DAUDWO010000076         2885 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.077, whole genome shotgun sequence.
ACCESSION   DAUDWO010000076 DAUDWO010000000
VERSION     DAUDWO010000076.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2885)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2885)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2885
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.077"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..361
                     /locus_tag="VHC05_001704"
     CDS             <1..361
                     /locus_tag="VHC05_001704"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402977.1"
                     /translation="TQELWLKCTIEQKNNTLIPEFRIDFSQTSYQQELQIKISNIYTM
                     GNTSILDRINTWGVNKFTNKLQFWIDIESVAGTQQLVQMLNSQIELDVTHSQNFYELS
                     LYRGVINYLNTGHRLRL"
     gene            870..2162
                     /gene="purB"
                     /locus_tag="VHC05_001705"
     CDS             870..2162
                     /gene="purB"
                     /locus_tag="VHC05_001705"
                     /EC_number="4.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate lyase"
                     /protein_id="HEQ5402978.1"
                     /translation="MIERYSRPEMAAIWTEENKYRAWLEVEILADEAWAELGEIPKED
                     VAKIRKKADFDIDRILEIEQDTRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTAY
                     GYLYKQANDIIRRDLENFTNIVADKAREHKMTIMMGRTHGVHAEPTTFGLKLATWYSE
                     MKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEQYVCDKLGIRPQEISTQVLPRDL
                     HAEYFAVLASIATSIERMATEIRGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSEN
                     MTGLARVIRGHMVTAYENVSLWHERDISHSSAERIITPDTTILIDYMLNRFGNIVKNL
                     TVFPENMMRNMESTFGLIYSQRVMLKLIEKGMTREEAYDLVQPKTAYSWDNQVDFKPL
                     LEEDTKVTSCLTQEEIGELFNPIYYTKRVDDIFKRLGI"
     gene            2294..>2885
                     /gene="rgg4"
                     /locus_tag="VHC05_001706"
     CDS             2294..>2885
                     /gene="rgg4"
                     /locus_tag="VHC05_001706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator Rgg4/ComR"
                     /protein_id="HEQ5402979.1"
                     /translation="MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSI
                     PSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELKYLILRTPTYMDDGKLQVREEQF
                     DEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
                     LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQF"
BASE COUNT          953 a          462 c          609 g          861 t
ORIGIN      
        1 tactcaagag ttgtggttaa aatgtactat cgaacaaaaa aataatacac ttattccaga
       61 atttcgaata gatttttcac agacatctta ccagcaagag ttgcaaataa aaatttcaaa
      121 tatatataca atgggtaata ccagtatatt agacagaatt aatacatggg gggttaataa
      181 atttacaaat aaattacaat tttggataga tatagaaagt gtggctggaa cacagcaact
      241 tgttcagatg ttgaatagtc aaatagaatt ggatgtaaca catagtcaaa atttttacga
      301 gctttcttta tataggggag taataaatta tttaaatacg ggccaccgac ttcgtttgta
      361 agattattgg aaattttatc tttttacaat atttagcaaa accttgtaac agaaataatt
      421 atgaattggg ttaataatta ggtgtatatt taactggaaa taaatagatt tgtttgaatt
      481 tagttgttta tgcaaattta aaaatgtatc tttcggaaag ttcggaagaa attagcatac
      541 tcattactaa gtgctaaagc aattgaaata ataaatagag agaggaatag ggatatcgta
      601 ttctcttaat tgaatacgga ctactaactt ccttaattca caaaatttta agaaatataa
      661 gaaaggagtg aggatgttac cgagtatttg aactcgggct aacttatctc ctcaatacac
      721 atcaaacaac agaaaggaaa tgggcactag tttcactaaa ctgaacccga gcggaaagct
      781 cggaatttag ataaaccgcc taggacgcaa gcgtccattg tcggttttct aaaattcagt
      841 cgctttctgg tcgcccttgg tatcttaaaa tgatcgaacg ttattcacgc cctgagatgg
      901 cggcaatttg gacagaggaa aataaatacc gtgcttggtt ggaggttgag attctggctg
      961 acgaggcatg ggcagagttg ggtgagattc ctaaggagga tgtggctaag attcgtaaga
     1021 aggcggattt tgacattgac cgtattcttg agattgagca ggacacgcgt cacgatgtgg
     1081 tggctttcac gcgtgcggtt tctgagacgc ttggtgagga gcgcaagtgg gtgcactacg
     1141 gtttgacgtc aactgacgtg gtggacactg cctacggtta cctctacaag caagctaacg
     1201 acattattcg tcgcgatctt gagaatttca ccaatatcgt ggcagacaag gcgcgtgagc
     1261 acaaaatgac catcatgatg ggtcgtaccc acggtgttca tgccgagcca acgactttcg
     1321 gtctcaagtt ggcgacttgg tacagcgaga tgaaacgtaa tattgagcgt tttgaacatg
     1381 ctgccgcagg tgtggaagct ggtaagattt caggtgccgt tggtaacttt gctaatatcc
     1441 ctccatttgt ggaacaatat gtctgtgaca aattaggcat tcgtccacaa gagatttcaa
     1501 cacaagttct tccacgtgac ctccacgcag aatattttgc agtgcttgca agtattgcaa
     1561 cttctatcga acgtatggcg acagagattc gaggtctgca aaagtcagaa caacgtgaag
     1621 ttgaagaatt ctttgccaaa ggtcagaaag gtagctctgc tatgcctcac aaacgcaacc
     1681 caatcggttc agagaacatg acagggctag cgcgcgtgat tcgtggtcac atggtgacag
     1741 cttatgagaa cgtgtcactt tggcatgagc gtgatatttc acactcatca gctgagcgta
     1801 tcatcacacc tgacacaact atcttgattg actacatgct caaccgcttt ggcaatatcg
     1861 ttaagaactt gactgtcttc ccggaaaata tgatgcgcaa tatggaatca acttttggtt
     1921 tgatttatag tcaacgtgtt atgctcaaat tgattgaaaa aggaatgaca cgagaagaag
     1981 cttatgactt agttcaacct aagacagctt attcctggga caatcaagtg gatttcaaac
     2041 cacttttaga agaagacacc aaagttacct cttgtcttac acaagaagaa attggtgaac
     2101 tatttaatcc gatttattac acaaaacgtg ttgatgatat ttttaagcgt ttagggattt
     2161 aatataaaaa aaaagaaggt gactcccttc ttttttattt aaaaaacgaa tattttcttt
     2221 aaaaatatta aaaaggttag tttttaatta gacgctgtga tataataaag aaaactgttg
     2281 ttggagagaa accatgttag aacattttgg tggaaaagta aaagtgttaa gacttgaaaa
     2341 gaggattagt cgcgaggact tgtgtgggga tgagtctgaa ctttctgttc gtcaattagc
     2401 acgaatagaa ctaggtcaat ccataccaag tttaagtaag gttattttta ttgcaaaagc
     2461 cttaaacgtt agtgtcggtt acttaactga tggtgctgat ttagaactac ctaagcgtta
     2521 caaagaatta aaatacctta tcttaaggac accaacttac atggatgatg gaaaattaca
     2581 agtacgagaa gagcagtttg atgaaatttt tgaggattat tatgataaat taccagagga
     2641 agagaaaata atcattgatt gtttacaggc aactttagat actttattga gtgagaatac
     2701 taactttggc attgacttac ttcaagaata ttttaatcaa ataaagacta aggtacgctt
     2761 taggcaaaat gatttaatac ttctagaatt atatttagct tatcttgata ttgagggaat
     2821 ggatggacaa tattcagata agatttttta tgattcttta ttagataatc tgtcagaaca
     2881 atttg
//
LOCUS       DAUDWO010000077         2743 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.078, whole genome shotgun sequence.
ACCESSION   DAUDWO010000077 DAUDWO010000000
VERSION     DAUDWO010000077.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2743)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2743)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2743
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.078"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            70..1812
                     /locus_tag="VHC05_001707"
     CDS             70..1812
                     /locus_tag="VHC05_001707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEQ5402980.1"
                     /translation="MANGSLIFLIVFLVVFLIYFNNFFVKKRSQELGVLAILGFSKRE
                     LTKLLTLENLVILVLSYLVSLLLGPTLYFLAVLAITHLLELTLEVQWFITANEIIESL
                     GILVVVFLINVITNGLIISKQSLIEFVNFSRKAEKKIKIRKVRAITAITALLLSYILC
                     LATVFSPTRNMLLSIGMVPVSLLIIVLVVLGTVFTIRYGLAFVVSLLKGNKKRLYRPL
                     SNIIYPKFNYRIATKNKLLTVLGGLLTVTVSVAGMMVMLYAYSLNGIERLTPSAIEYN
                     VESENGQVNVTTILENDQVSLVDVDLLRLNTNPEVTITESGQTIPYFDIINYSDYKEL
                     MKAQGRINSIEGSKSLPLLINYYPTEISLGKTFNLGNAYDVTVKQVSTHNVFSFSTSV
                     TTLVVSDKLYAKLSSCFPEKEMTIRTFNGTSIRSSEAFYNQFSMVPDVISSYSKEYTV
                     KTANIATYIFITFLSILFIICTGSILYFTSLIEIMENKEEYGYLSKLGYSKKMIHRIL
                     RYETGILFLIPVFIGIVNGGMLLIYYKYLFMDTLVAGNIIMLSLLLCLLFFLIIYGTF
                     YVLTLRSVTSIIKN"
     gene            1852..>2743
                     /locus_tag="VHC05_001708"
     CDS             1852..>2743
                     /locus_tag="VHC05_001708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5402981.1"
                     /translation="MIRIKNITKSKFFGTAIILLQQLIALLILVYNRENLSLLFSEKV
                     ALVMTLIDTAFIWLATILRQKQGDIFKRIISIISLTIWQYLVSVLTRGTPLFLSSGLQ
                     IILLYCYTVEITNLILYGHKQFKDKLDKGLLIIIFVSITSLFVNRILFNFLFLMVFTI
                     LHLYPLLVIVLYYRSFRQQISVVRRSLILFSLLLLVILGSELYGEMLDVNQAFNNLGW
                     YLFPLIMSVIYYFKTIHDKLSFVIQRWLGDYKARIELLFLLLILCWVVLIKVLVKEFL
                     LFFIIVDASTLFCLVVISCIF"
BASE COUNT          874 a          375 c          458 g         1036 t
ORIGIN      
        1 gcttttctaa attttatctc agataaaatc attacagaaa aaattgggga tagtggtcaa
       61 gctctagtta tcgctaatgg gtcattaatt tttttgattg tatttttggt ggtattctta
      121 atttacttca ataatttctt tgtaaaaaaa cgtagtcaag agcttggagt cttagcaata
      181 ctagggtttt caaaaagaga attaacaaaa ttactaactt tagaaaatct tgttattcta
      241 gttctgagtt acttggtaag tttattgctg ggaccgactt tatatttttt agctgtactg
      301 gcaattactc atctattgga attaacattg gaagttcagt ggtttattac agctaatgag
      361 attatagagt ctttaggaat attagttgta gtttttctga ttaatgtcat cacaaatgga
      421 cttatcatta gtaaacagtc tttgattgaa tttgttaatt tctcaagaaa ggctgagaaa
      481 aaaattaaga taagaaaagt cagagctatt actgctatta ctgcattgct attatcatat
      541 attttatgtt tggcgacagt attttcaccc acacgaaata tgctattaag catagggatg
      601 gtaccggttt ctctattgat aattgtttta gttgttttgg gaacagtgtt taccatcaga
      661 tatggattgg cttttgtagt ttcgttatta aaaggaaata aaaaaaggtt ataccgtcct
      721 ctgtctaata tcatctatcc caaatttaac tatcgtattg caacaaaaaa taaattatta
      781 acagtcttgg gaggtctttt aacagtaacc gtttcagttg ccggaatgat ggtaatgctc
      841 tatgcttatt ctcttaatgg gatagagagg ttgactccat ctgccataga atataatgtt
      901 gaatcagaaa acggtcaagt caatgttaca actattttag agaacgacca agtgagcttg
      961 gttgatgttg acctattgag attgaacact aacccagaag taactatcac agaatctggg
     1021 caaacaattc cttattttga tataattaat tacagtgatt ataaagagtt aatgaaagct
     1081 caagggagaa taaattctat tgaaggtagt aagtcactcc cattgttaat aaattattat
     1141 ccaacagaaa ttagccttgg aaaaaccttt aacttaggaa atgcatatga tgttactgta
     1201 aaacaagtat caacgcataa tgtttttagt ttttctacaa gtgtcacgac cttggttgtt
     1261 tctgataaat tatatgctaa acttagttct tgttttccag agaaagaaat gacaattagg
     1321 acttttaatg gaacttcgat taggtcaagt gaagcatttt acaatcagtt tagtatggtt
     1381 cctgatgtta tcagtagtta tagtaaggaa tacacagtaa agactgctaa tattgcgact
     1441 tatatcttta taactttcct atccatactc tttattattt gtacaggtag tattctgtac
     1501 tttacaagcc tcatcgaaat catggaaaat aaagaagaat atggctatct aagtaagcta
     1561 ggttatagta aaaaaatgat tcatcggatt cttcgatatg aaacaggtat acttttcctt
     1621 attcctgtat tcattgggat tgtaaatggt ggtatgttgc ttatttacta taaatattta
     1681 ttcatggata cattggtagc aggcaatatc ataatgttat ctttattgct ttgtctgctt
     1741 ttcttcttga taatatatgg cacattttat gtattgacat tgcggtcagt gacatccata
     1801 atcaaaaatt aattttaaaa atcttttaac tttaacgatt aagtaaataa tatgataaga
     1861 ataaaaaaca taacaaagag taagttcttt gggactgcaa taatcttgtt gcaacaatta
     1921 atagccttgt taattttggt ctataatcga gagaacctgt ctcttctttt ctctgaaaaa
     1981 gtagctcttg taatgaccct tattgataca gcttttattt ggctggcaac aatattacgc
     2041 caaaaacaag gtgatatttt taaaagaatt atttctatca tctccttaac aatttggcaa
     2101 tacttagtat ctgtgctgac aagaggaact cctctctttt taagcagtgg actacagatt
     2161 atattgctct attgttatac cgttgagatt actaatttaa tattatatgg gcacaaacaa
     2221 tttaaagata agttagataa gggcttgtta ataattattt ttgtttctat aactagcctt
     2281 tttgttaata gaattttatt taatttttta ttcctgatgg tttttactat tttacacctg
     2341 tatccgttac tagttatagt gctatattat aggtccttta ggcaacaaat atcagttgtt
     2401 agacgttcat tgatactatt ttctttactt ttgctggtaa tacttggtag tgaactttat
     2461 ggagaaatgc tagatgttaa tcaagccttt aataatttgg gatggtatct gtttcccctt
     2521 ataatgagtg taatatacta ttttaagacc atacatgata aattgagttt tgttatccaa
     2581 agatggttag gtgattacaa agctcgtata gaactattat ttctacttct tatcctttgt
     2641 tgggttgtac tcataaaggt actagttaaa gaatttttat tattttttat aattgttgac
     2701 gcaagcacgt tattttgtct agtggtaatt tcttgcatct ttt
//
LOCUS       DAUDWO010000078         2228 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.079, whole genome shotgun sequence.
ACCESSION   DAUDWO010000078 DAUDWO010000000
VERSION     DAUDWO010000078.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2228)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2228)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2228
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.079"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(51..788)
                     /locus_tag="VHC05_001709"
     CDS             complement(51..788)
                     /locus_tag="VHC05_001709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000812013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEQ5402982.1"
                     /translation="MKQLVLKDVCKKYPNQLNYALDHINLTVRKGEFVAVMGRSGSGK
                     TTLLNVTSIIDKIDSGNIYCADKEISVFSDNEATSFRKNDIGFVFQDYMLLDSLTIRE
                     NISVALSLKNIDSSKIDDLINSYAKRFNLYEQLKKYPYQLSGGQRQRVSIIRAIIKEP
                     EIIFADEPTGALDLKSSEETMMILSEINKTEKVTILMVTHDVLSASYADRVVLLKDGK
                     LHMEIDKKDCGESFYDVISQALSDRGE"
     gene            complement(785..1462)
                     /locus_tag="VHC05_001710"
     CDS             complement(785..1462)
                     /locus_tag="VHC05_001710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEQ5402983.1"
                     /translation="MNLKVHSGEFVAIIGKSGSGKTTLAKMLLGYVSPSSGDITYNNI
                     SYSKIDKTDFRNISAFVSQDSPIFDGDVMYNISLGRESVSGEQVIETCKRVSLYEDIR
                     SMPMKFHTPLFRDNPSLSGGQKQRISLARELVTTPRILVLDEPTSALDVKTERIIQKN
                     VEALHCTRVLVTHRLNTVEKADKILIMDNGKIIDYGNHHYLYKNNKDYCDLYDSYMNK
                     YQEEEAK"
BASE COUNT          741 a          421 c          273 g          793 t
ORIGIN      
        1 ataacgaaaa atttttttta atgttagatt ttgtaatgga ccaaatcata ttactctcct
       61 ctatcggata aagcttgact aattacatcg taaaacgact ctccacaatc ttttttatca
      121 atctccatgt gaagtttccc atctttgaga agtacaactc tgtcggcata agaagctgat
      181 aaaacgtcat gagtaaccat taaaatagtt accttttctg ttttattgat ttcactcaaa
      241 atcatcattg tttcctcaga agatttcaag tcaagtgctc cagttggttc gtcagcaaaa
      301 ataatctctg gttctttaat gattgctctg ataatactga ccctctgtct ttgacctcca
      361 gaaagttgat acggatattt cttcaactgt tcatataaat taaatctttt tgcatagcta
      421 tttatcaaat catcaatctt tgaagaatca atatttttta gagacaaagc aacagaaata
      481 ttctccctaa tggttagact gtctaacagc atataatctt gaaaaacaaa accaatatca
      541 ttttttctaa aactagttgc ctcgttatca gaaaatacac taatctcttt atccgcacaa
      601 taaatattcc cactatcaat tttatcaata attgaagtaa catttaaaag cgtcgttttc
      661 ccactaccgc tacgccccat gacagctaca aattctcctt ttctaacagt caaattgata
      721 tggtctagag cataattcag ttgattggga tattttttgc aaacatcttt taatactaat
      781 tgtttcattt tgcctcttcc tcctgatatt tattcatata cgagtcatat aagtcacaat
      841 aatccttatt atttttgtac aaataatgat ggtttccata gtcaataatt ttgccattat
      901 ccattattaa aatcttatca gctttttcaa ctgtattaag tctatgggta accaaaaccc
      961 tcgtacaatg taaagcctca acattttttt ggattattct ttcagttttt acatctaaag
     1021 ctgatgtagg ttcatcaaga actaagattc taggggtagt tactaactct cttgctaaag
     1081 aaattcgttg tttttgcccc ccagatagtg atggattatc tcgaaaaagt ggagtatgaa
     1141 acttcattgg catactcctg atatcctcat atagtgatac ccttttacaa gtttcaataa
     1201 cctgttctcc tgaaacagat tctctcccta gcgaaatgtt atacatcaca tccccatcaa
     1261 atatgggaga atcttgagat acaaaagccg atatattcct aaaatcagtt ttatcaattt
     1321 tagagtagga tatattgttg tatgtgatgt ctccactact agggcttaca tagcctaaca
     1381 acatcttagc tagagttgtc tttccacttc cacttttccc tataattgca acaaattctc
     1441 ctgaatggac ttttaggttt attccattta acacctctgc cccatttaac tcatagtgat
     1501 agtttatatt ttctaaattt atctctatat ctgtatcctc tgatagctta taagtgccat
     1561 tcgcctcatc atcaagagtt gatatctcta ataccctttc gtaatgctta acaccatata
     1621 gaatctcatc aatcgaattc aaaatattat taatgggatt aataaaattt aaaaccatca
     1681 tataaagaag aataagctca ccactgctac tatttggtga ataatataga aataacagaa
     1741 ttaacaaaat aggtatggaa aaagttatca cataatttac tgctcctaaa agattgaaat
     1801 atctatttct atcatatgtt gaattgatat agtccttaaa acttttatcc cattttgaca
     1861 aaagttcttt ttcagaattt ttagctttaa aaagaaatag cccgtccatc agtgaaaaaa
     1921 atgtttgtaa agagttcttt tgtcttaaaa cttctttacc taacttttct tgtttaatgc
     1981 ttagtgatag gaaaaaaatc atcatttcta caataaaaac tatacccaat ataactccca
     2041 aaggtgtaga aacatatgtg atataactaa tactcgcaaa cattaagata atatccaacc
     2101 agatagaaat aattctttct gatagtaact ccctcacaat catcaaacca ttatatctat
     2161 gaatgatgtc tgttttatct atttttccaa tatattctat gggaagtttc aataacttag
     2221 tcacaaac
//
LOCUS       DAUDWO010000079         2126 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.080, whole genome shotgun sequence.
ACCESSION   DAUDWO010000079 DAUDWO010000000
VERSION     DAUDWO010000079.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2126)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2126)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.080"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(1..1351)
                     /locus_tag="VHC05_001711"
                     /pseudo
     CDS             complement(1..1351)
                     /locus_tag="VHC05_001711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /note="internal stop; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin secretion accessory protein"
     gene            complement(1362..>2126)
                     /locus_tag="VHC05_001712"
     CDS             complement(1362..>2126)
                     /locus_tag="VHC05_001712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEQ5402984.1"
                     /translation="VDSEFQEAGTLVNQELLHGNIQFEELSYKYGFGRDTLSNINLTI
                     KQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHINYLPQ
                     QAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSG
                     GQKQRIALARALLTKAPVLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSIS
                     ARTNQVIVLDEGKIIETGSHQELMTKQGFYHHLFSG"
BASE COUNT          614 a          342 c          391 g          779 t
ORIGIN      
        1 tgagtatctt atctttatag taattgaaat agcttttccg tgtaatgaca cttgttacac
       61 gtccttgcaa tccatactgt acgacgtcac tgtccttatt agaaagtttg gagagtgcag
      121 taaccttgaa gagattacct tgatcagtct ttgtggcaga tttatcaata gtctgaatcg
      181 ttccgttaat tgttagagtt tggtttccaa ctttttcaag actaagacga acaccttgct
      241 tttcttttaa caatgagaca tgctctgaag tgacgtagta ggtaatgaat acttccttta
      301 ttttttggat atctgggtag atttgagcca cctcacttcc attaggaatg agagatttcc
      361 cttcaaattc actgtttaga tgtatcgttc ctgtttcagg agctataatt atattgttct
      421 ttagctgaat attggcttgc tcaatttgat ctttaagttc agtaatttga ttttcaactg
      481 tggtaagttg ttgggaagca ttttgcagaa attgtgtttt taaaatatct attttgatcc
      541 tatgactagt gtctggaaga gataaatttc ctgtactagc acgttggata ctaaggtttg
      601 ccattgaaga ttcaagttct gagatatttt gtgagatttg agaaaggtat tcttctttta
      661 aagctgagtt atcttcttgt gcttgaaatt gagtttgata tttttttagg gcagtttgat
      721 gtggattctc aggtgaaagc ttatattctt gattattaat agctcgcttt agctcttcat
      781 aatctgtaat tttttgatga agttcgtcaa gctgactagt aataactgaa atggcatgat
      841 tagcaagact tgcttgatta ttgacttcag catttttttt agcaaaccca atgattatat
      901 cttgggtttg ctaaaaaaaa tgattaaacg tatcgctata gccgaattca tcttctccct
      961 taaataagtt agtttcttgt tctagactgg ttttgagtat ttggagtcca tttttttgtt
     1021 tgttaagagt ggctaattgt ttttctaaag cttttttttg agaattttcc attgtttttg
     1081 agtattggat aataacatca cctttcttaa taaatttatt gttttttaaa ttgttgacga
     1141 caatagtatg gtcactagtt gattggactg aagcaataac ttttgttggc gtcatttctc
     1201 cttgtgaagt aatggtaatt tcttttttag caaagagaga aaaaagaact aagaagctca
     1261 ctaacaaaac ggatggcaaa atcaagaaag ttgcaaagtt atgatgacgt cgatgataaa
     1321 attccgcact tttaaagagg tttggattca tgttattctc cttaaccact aaataaatga
     1381 tgatagaaac cttgtttagt cattaattct tgatgagatc ctgtttcaat aattttgccc
     1441 tcatcaagca caatgacttg attggtccgc gctgaaatgc tgagacgatg agctacgaaa
     1501 ataatagttt tatccgtcat agccaaaaga ttatcaataa ccctcttttc agttagtacg
     1561 tcaagaccgc ttgtagcctc atctagaata agcacaggcg ccttggttag gagagctctg
     1621 gcaagcgcaa ttcgttgctt ttggcctcct gagagtccgg caccatcaga aagctctgtt
     1681 tgatagccca taggcatttg ttcaatatct tgtcgaattt ctgcaacctc acaagctctt
     1741 agaatatctt catgactagt acagtcatta gcacctaagg ttaaattttc taaaatagaa
     1801 ccattaaaaa tataggcttg ttgggggaga taattaatat gttggcgaag acttttttta
     1861 tcaatcattt ttaagtcatt atgattaatg gtaattcggc cgttataagg ctcaaaaaaa
     1921 ttaacaatca ttttagctag agtcgtttta ccagatccac taataccaac aaggctaact
     1981 ttgtcccctt gcttaatagt gagattaata tttgatagag tatcgcgtcc aaagccatat
     2041 ttataggata actcttcaaa ttgaatgttt ccgtgtaata attcttgatt gactaatgtc
     2101 ccagcctctt gaaattcaga atcgac
//
LOCUS       DAUDWO010000080         2090 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.081, whole genome shotgun sequence.
ACCESSION   DAUDWO010000080 DAUDWO010000000
VERSION     DAUDWO010000080.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2090)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.081"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(<1..2055)
                     /gene="lanM"
                     /locus_tag="VHC05_001713"
     CDS             complement(<1..2055)
                     /gene="lanM"
                     /locus_tag="VHC05_001713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000480042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 lantipeptide synthetase LanM"
                     /protein_id="HEQ5402985.1"
                     /translation="MFLSMKTLVLDINHFSKEIENKSKAYEQYIQQIREENGISNFFD
                     RYPYLLKQINREVGLVVESYSLLFDRFLKDLSEIRSCFNITESLSNVEFSLGDSHSQK
                     QTVVKIEFKGKSVYYKPKSYDSYNILLELISLLKSNNIPSFSLPESLIKADYCWQLGV
                     AYTSSNKDEVAKIYFKYGVLAAFSEIFSITDLHMENVIVSGGDLYLIDVETFFQRKLN
                     VQNQNFEGITVDTYQRIYKTSLSNGLFPVQFEKNSAPNVSGISGKGGKRKKGKYELIN
                     KNRGDMKLVKTDYFQEDGYNILTLNGKVVEPLDYANEVIAGFRECYTFLMSQRAKVKK
                     ILEDFPKLKTRAIFRNTSDYGKFLQASTNPKYLFSEKKRENLFSILHESKHIEQFIVV
                     SEIKDLMNGDIPYFSMDTSGNVYNSLGTVIGNLGETTSLFDNIVTLNDERMKFTCELL
                     GIVLKKPIKHWEREKGKSYQFLSISSEHNFSEEILDSIRRIFIDADKNSFSSEEEITW
                     LNIDITETEQWVISPQNITLYNGLIGNALGYLYAYQILGEEQYLVSLNKILKTLETTK
                     NLIETSDMSVFLGKGGLIYLYFSLWKRLKLPQYQKLYLDIIKEFSSQSLEEQNIDYIS
                     GVSGLLVVLCNIYNVEQNKTVYHLINRISEFIIDNVKKEDDKVYWVSDFSDSEILNGL
                     SHG"
BASE COUNT          681 a          387 c          258 g          764 t
ORIGIN      
        1 tccgtgagat agtccattta gaatttctga atctgaaaaa tccgataccc aataaacctt
       61 atcatcttct tttttcacat tatcaataat aaattcagat atcctattaa ttaaatgata
      121 tactgtttta ttttgctcta cattatatat gttgcacaga acaactaata aaccagacac
      181 tccagaaata taatctatat tttgctcctc tagtgactgg ctggaaaatt ctttgattat
      241 gtctaaatat aatttttggt attgaggtaa tttaagtctt ttccacaaac taaagtatag
      301 ataaatcaaa cctccttttc ccaaaaaaac tgacatatca ctagtttcta taagattctt
      361 tgtggtttcc aatgttttca atatcttatt taatgatact agatattgct cttcaccaag
      421 aatttgataa gcatataaat aacctaaggc attcccaatc aatccattat acaaggtaat
      481 gttctgagga gatattaccc attgctcagt ctctgtaata tcaatattga gccatgttat
      541 ctcctcctct gaagaaaagc tattcttatc tgcatcaata aatattcgtc taatgctgtc
      601 taagatttcc tcactaaaat tgtgttctga ggagattgat aaaaactgat aagatttgcc
      661 cttttccctc tcccaatgct taatcggttt tttcaagact attccaagca attcgcaagt
      721 gaacttcatt ctttcatcat tcagggtaac tatattatca aataatgagg ttgtctctcc
      781 tagatttcca attactgttc ctaaagaatt atatacattt ccactggtat ccattgaaaa
      841 gtaaggaata tcaccattca tcaaatcttt aatttcacta acaacaataa attgttcaat
      901 atgttttgac tcatgtagta tcgaaaataa attctccctc tttttttctg agaaaagata
      961 ttttggattc gtagaggctt gtaaaaattt tccatagtcg gaagtatttc tgaatatggc
     1021 tctagttttc aattttggga aatcttctaa aattttttta acctttgcac gttgcgacat
     1081 aagaaatgta tagcattctc taaaacctgc aattacctca ttagcatagt cgagaggttc
     1141 caccactttc ccatttaatg tcagaatatt ataaccatct tcctgaaaat agtcagtttt
     1201 cactaacttc atatctccac gatttttatt tatcagttca tactttccct tttttctttt
     1261 cccacctttt ccacttatcc cagaaacgtt aggagcgctg tttttctcaa attgtacagg
     1321 aaataaacca tttgaaagtg atgtcttata aattctctga taggtgtcta cagtaatccc
     1381 ttcaaaattc tgattttgta cattcaactt tctttgaaaa aaggtttcaa cgtcaattaa
     1441 atataaatct ccgcctgaaa caatcacatt ttccatatgt aagtccgtaa tagaaaatat
     1501 ttcagaaaat gctgctaaaa caccatactt aaagtaaatt ttcgctactt catctttatt
     1561 ggaacttgta taagctacac caagttgcca acaataatcc gctttaatta agctttcagg
     1621 aagactgaac gaaggtatat tattagattt caatagacta ataagttcca acaagatgtt
     1681 gtatgaatca tagcttttag gcttgtagta aacggatttc cctttaaatt caatcttaac
     1741 gactgtttgt ttttgagaat gactgtctcc aagtgaaaat tcaacattac ttaaggactc
     1801 agtaatatta aagcatgacc ttatttcaga caaatctttt aaaaacctat caaatagcaa
     1861 agagtatgat tccactacca atccaacttc tctattgatt tgttttagca aatatggata
     1921 tctgtcaaaa aaattactta tcccattttc ttcccttatc tgctgtatat attgttcata
     1981 tgcctttgac ttgttttcaa tttccttgga aaaatgattt atatctagaa ctagtgtttt
     2041 cattgaaaga aacattatag tttcaaataa ctgattttca aactcactat
//
LOCUS       DAUDWO010000081         2087 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.082, whole genome shotgun sequence.
ACCESSION   DAUDWO010000081 DAUDWO010000000
VERSION     DAUDWO010000081.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2087)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.082"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..478
                     /gene="rlmH"
                     /locus_tag="VHC05_001714"
     CDS             <1..478
                     /gene="rlmH"
                     /locus_tag="VHC05_001714"
                     /EC_number="2.1.1.177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002991465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="HEQ5402986.1"
                     /translation="KVKLICVGKLKERYLKDGISEYQKRLSRFCQFEMIELTDERTPD
                     KASFADNQLIMSKEAQRIHKKIGERDFVIALAIEGKQFPSETFSELISGVTVKGYSTI
                     TFIIGGSLGLDSIIKKRANMLMSFGLLTLPHQLMRLVLTEQIYRAFMITQGSPYHK"
     gene            complement(635..708)
                     /locus_tag="VHC05_001715"
     tRNA            complement(635..708)
                     /locus_tag="VHC05_001715"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(672..674),aa:Arg,seq:tct)
     gene            914..1894
                     /locus_tag="VHC05_001716"
     CDS             914..1894
                     /locus_tag="VHC05_001716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001871253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HEQ5402987.1"
                     /translation="MSNINSTRKSSYSHLSATERGEIAAYLKMGKKPVEIARLLGSHR
                     STICREIKRGSVDQVKDKNGKQTFFNAYFADSGQRVYETNRQKSSYLKLNGCSARFIA
                     QLESALTANIRLHSVDSFVQTYKVNHPEEVVPSTKTIYRYIKEGVLAIKPIDLPKMVS
                     IRKRSKKVMKTNKKTLGKSIEERPEYINDRSEFGHWEIDLVLGKKTKGEAVMLTLVER
                     QTRHALGVKLEDKQSQTINRAVTHLISQYPIASITADNGSEFSLLSTLEAVDVYFAHP
                     YSSHERRTNENFNGLLREYVPKGVSLNPLTSEELDNDITAINERLRRLLQ"
BASE COUNT          727 a          381 c          376 g          603 t
ORIGIN      
        1 gaaagtaaaa ctaatttgtg ttggaaaact aaaagaaaga tacctcaaag atggtatttc
       61 agaatatcaa aaaagacttt cccgtttttg tcaattcgaa atgattgagt taactgatga
      121 aagaacacca gataaagcaa gttttgctga taatcaattg attatgagta aagaagctca
      181 gcgaatccat aaaaaaattg gggaacgtga ttttgtaatt gcattagcta ttgaaggaaa
      241 acagtttcct tcagagacat ttagtgaatt aatatcaggg gttactgtta agggatattc
      301 aactatcacg tttattattg gtggaagtct tggattagat tcaattatta aaaaaagagc
      361 taatatgcta atgagttttg gattgttaac cttacctcat cagttaatgc gtctagtcct
      421 tactgagcaa atttatcgtg cttttatgat tacacaaggc agtccttatc ataagtaaga
      481 gagtgtgaac tggaataact aactcttacc actttattag ataatagttt ggtataatta
      541 aaagcaaata ttaaaaaaag acagactaaa tcctatcttt tcaatacact aaggtaaata
      601 caaaaaaagc actaaaacag tgctttttta tctttgatcc cagcaggatt cgaacctgcg
      661 accgttcgct tagaaggcga atgctctatc cagctgagct atgagacctt aaccacatca
      721 ttttaacaaa aattatctaa aactgtcaat atttatttta aaaaaactgg aaaataacat
      781 gatatcccgc gttgtaaaat gaagtgcaac aaaaaagaca tgatatcccg cgttgtaaaa
      841 tgaagtgcaa caaaaaagac atgttcgtct gatatactag aattccccaa ttcagtatgg
      901 aaagcagatg aacatgtcta atattaattc taccagaaaa tcatcctatt ctcatctttc
      961 agccacagaa cggggtgaaa ttgctgctta tcttaaaatg ggaaagaaac ccgttgagat
     1021 tgctcgactt ctaggtagtc accgttctac aatctgccga gaaataaaac gtggttcagt
     1081 agatcaggta aaggataaga atggaaaaca aaccttcttc aacgcctatt tcgctgatag
     1141 tggacaacgt gtctatgaaa ccaatcgtca aaagagttct tacctcaaat tgaatggctg
     1201 ctccgctagg ttcattgcac aattagaatc tgccttgacg gctaacattc gtctccatag
     1261 tgtggatagt tttgttcaga cttacaaagt gaaccatcct gaagaagtcg tcccctctac
     1321 caaaacgatt tatcgttata tcaaagaggg ggtgttagct attaaaccaa tcgatttgcc
     1381 taagatggtt agtattagaa aacgttctaa gaaagtcatg aagacgaata agaagacttt
     1441 aggtaaatct atcgaagaac gtccagaata tattaatgat cgttctgaat ttgggcattg
     1501 ggagattgat ttggttctcg gcaagaaaac caaaggtgaa gctgttatgt tgactttggt
     1561 agagcgccag acacgccatg cactaggagt taagctagaa gacaagcagt cccaaaccat
     1621 taaccgtgct gtcacgcatc tcatcagtca gtatcctatt gcatccatca cagcggataa
     1681 tggttctgag tttagtttac tctcaacctt agaagctgtt gacgtttact ttgcacatcc
     1741 ctattcttca catgagagaa gaacaaacga gaacttcaat ggcctcctca gagaatatgt
     1801 ccctaaagga gtctcactta atccactaac ctctgaagaa cttgacaatg atattactgc
     1861 catcaatgag cgcctaagac gacttcttca atagcaatcc tcaaaattcc tgtttgagct
     1921 atcccgaaca gcttaacctc tggaactcta gttatctatg aactcgttgc acttgacttg
     1981 acaacttgcg gtttaaaaaa aatcaaattt tttttaaaaa aagtatagac aaaaaaaatc
     2041 aatctgctat aatagtaaga gtgttaagga gatatcctcc aaaactt
//
LOCUS       DAUDWO010000082         1964 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.083, whole genome shotgun sequence.
ACCESSION   DAUDWO010000082 DAUDWO010000000
VERSION     DAUDWO010000082.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1964)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1964)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.083"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            635..1246
                     /gene="rpsD"
                     /locus_tag="VHC05_001717"
     CDS             635..1246
                     /gene="rpsD"
                     /locus_tag="VHC05_001717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S4"
                     /protein_id="HEQ5402988.1"
                     /translation="MSRYTGPSWKQSRRLGLSLTGTGKELARRNYVPGQHGPNNRSKL
                     SEYGLQLAEKQKLRFSYGLGEKQFRNLFVQATKIKEGTLGFNFMVLLERRLDNVVYRL
                     GLATTRRQARQFVNHGHILVDGKRVDIPSYRVDPGQVISVREKSMKVPAILEAVEATL
                     GRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML"
     gene            complement(1401..1934)
                     /locus_tag="VHC05_001718"
     CDS             complement(1401..1934)
                     /locus_tag="VHC05_001718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEQ5402989.1"
                     /translation="MVNRKENTKQAILKAMVMLLKTESFDDITTVKLSKRAGISRSSF
                     YTHYKDKYEMIDYYQQTFFHKLEYIFEKKYQNKEQAFLEVFEFLQREQLLSSLLSANG
                     TKEIQAFIINKVRLLITTDLQDKFRTEELSQTEKEYRSIYLAHAFFGVCQSWIAKGKK
                     ESPQEMTQFVLKMLTST"
BASE COUNT          625 a          343 c          344 g          652 t
ORIGIN      
        1 aattcctata aaagataata tttttaggtt agattgaggt aaaaaagagg tcttcaccat
       61 ggttaagcaa atgatcttag tactaaggtt aaaagattat cgtgaaataa agttttgaca
      121 caagtgtaat taatagagga acttgaagta tccgataaaa ctatcttgaa gtgaaaaaac
      181 gagtaaaact cccctgataa atacaatata ctagccattt cagagcaatt aagagtttcc
      241 agtgaagtgc ttttggtaga gagctaagaa aaaacagtca aggtttaaga actgcaaatt
      301 agcatttaaa ttattttttg ttaatgacag ttgtctttat taccataact ataacttctt
      361 ataatatagt cttcttattc atcagtggtg gttcgtctca tatctgacct taaaatatta
      421 aactgatcat cagatgatag atagactgac tttacaaaac aactttctta tggtaaaatg
      481 ttctttgtgc gaaataacag cagaaaaata tgaagctcgt caacaggtgg ttatctattc
      541 aagtaacctt tgctgtttag gcgaaaaccc cctgcacgaa tcaggatttt ttaaaccgtt
      601 atttcctcaa aaaatttaga ggaggacatg taatatgtca cgttatactg gtccatcatg
      661 gaaacaatca cgtcgccttg gtttatcact tacaggcaca ggtaaagaat tggcacgtcg
      721 taactacgtt cctggtcaac acggtccaaa caaccgtagc aaactctcag aatatggttt
      781 gcagttagct gagaaacaaa aacttcgttt ctcatacggt ttaggtgaaa aacaattccg
      841 taacttgttc gttcaagcta caaaaatcaa agaaggaact cttggtttca actttatggt
      901 tcttttagaa cgtcgtcttg acaacgttgt ttaccgtcta ggtttagcaa ctactcgtcg
      961 tcaagcacgt caattcgtta accacggtca catccttgtt gacggtaaac gcgttgatat
     1021 cccttcatac cgcgttgatc caggtcaagt gatttcagtt cgcgaaaaat caatgaaagt
     1081 acctgcaatc cttgaagctg ttgaagctac tcttggacgt ccagctttcg tatcatttga
     1141 tgctgaaaaa cttgaaggtt cattgactcg ccttccagaa cgcgatgaaa ttaacccaga
     1201 aatcaatgaa gcacttgtcg ttgaattcta taacaaaatg ctttaatttt aagattaaac
     1261 ttacaaaaag cctatttaac aggctttttt tgtatctcat aacaaattta tcctgatccc
     1321 ttcattttac tatggcttct aaaaaaagtt atcactaagg ctgatgactt gtaaaatgat
     1381 cctttcgtaa gggttactat ttaggtactc gtaagcattt tgagaacgaa ttgtgtcatt
     1441 tcttgaggtg attctttttt acctttagca atccaacttt gacagacacc aaaaaaagca
     1501 tgggctaagt agatacttcg gtattctttt tccgtttgag ataactcttc ggtgcggaac
     1561 ttgtcctgta aatcagtagt gatgagtagg cgaactttat tgatgataaa ggcctgtatt
     1621 tctttggtac cgttagcaga caaaagggaa gagagaagct gttctctttg gagaaattca
     1681 aatacttcaa ggaaggcttg ttctttattt tgatattttt tctcaaaaat atattctaat
     1741 ttgtgaaaaa aggtttgctg ataatagtca atcatttcat atttatcttt atagtgtgtg
     1801 taaaaactag agcgactaat tccagctctt ttagataatt taactgtggt aatatcgtca
     1861 aaactttcgg tttttagtaa cataaccatt gcttttaaaa ttgcttgctt cgtattttct
     1921 ttacggttga ccatctacca tctctccttt tgaacacttt taga
//
LOCUS       DAUDWO010000083         1962 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.084, whole genome shotgun sequence.
ACCESSION   DAUDWO010000083 DAUDWO010000000
VERSION     DAUDWO010000083.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1962)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.084"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(15..941)
                     /locus_tag="VHC05_001719"
     CDS             complement(15..941)
                     /locus_tag="VHC05_001719"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011106857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HEQ5402990.1"
                     /translation="MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNI
                     GVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNITLPYKREVMRYIDNLDRVAEIT
                     GSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFTLQKLQ
                     ISPTVVYREPISENTRSLIKSFPDLKYITYKELADQQILNDIEIIINTTPVGMINYEE
                     SLPINFDHLDNVNYKDKYFMDVVFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFS
                     LWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK"
     gene            complement(1010..1081)
                     /gene="shp3"
                     /locus_tag="VHC05_001720"
     CDS             complement(1010..1081)
                     /gene="shp3"
                     /locus_tag="VHC05_001720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_128650800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide pheromone SHP3"
                     /protein_id="HEQ5402991.1"
                     /translation="MKKISKFLPILILAMDIIIIVGG"
     gene            1161..>1962
                     /gene="rgg3"
                     /locus_tag="VHC05_001721"
     CDS             1161..>1962
                     /gene="rgg3"
                     /locus_tag="VHC05_001721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985634.1"
                     /note="Regulator gene of glucosyltransferase 3; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system transcriptional regulator
                     Rgg3"
                     /protein_id="HEQ5402992.1"
                     /translation="MKSKLGATLRKVRKGKQISLCFVADEHLSKSQISRFERGESEIS
                     CIRLINILDKLHITLDEFLILHDEDYTNSETFANLVQYIRKQYSSQNINNIACLLSDT
                     SDYTLNSFEKTMVKSILHTMDSSIIPSDDELLQLTDYLFKVEKWGYYEILLLGNCVRT
                     INYNSYFLLTKEMLNNYIYSSRNKTNKRIVTQLAINCFILSINKEEFSNCSYLIDEIK
                     TLLDNELNFYEQTVFLYATGYFEFKRQLETGVEKMKQAIQVLDILNEDK"
BASE COUNT          690 a          331 c          255 g          686 t
ORIGIN      
        1 tgtaatatga aaagtcattt tccttttatc ttcccttcta gaaatgtatg aattaggaca
       61 acatcatctt ttgaaaaaaa atatttacca tcattaattt tatcactcca caatgaaaat
      121 gcttcaattc cctgaaaaat caaaacccat aaaccatcaa ttatttttgc tcctttttta
      181 ccaaaatatt catgaagttt cgtatgtaaa ggattgaaaa ctacatccat aaagtattta
      241 tctttataat taacattgtc caaatgatca aaatttatag gtaaactttc ttcataattt
      301 atcataccaa ctggtgtagt atttattatg atttctatat catttaaaat ttgttgatca
      361 gccaattcct tatatgtaat atactttaaa tcagggaaac tctttatcaa acttcttgta
      421 ttctcactaa ttggctccct gtatacaact gttggtgaga tttgtagttt ttgtaaagtg
      481 aaaatagcag ctctagcagt accgccagtg cctaaaacac aacattttgt tatatggcta
      541 atattaaaga aaactaatgt attataaata cctttccaat cagtattagt tcctgtaatt
      601 atatttccag atttataaat attgttaaca gatccagtta tctctgctac tctgtctaaa
      661 ttgtcaatat acctcattac ctctctttta taaggtaaag ttatatttaa tccaatacat
      721 tttggatcat ttatcagatg tttgatttta tcttctaaac acactgagtc taccaaaatt
      781 tttttatgtt tatattcatc cagaactcct atgttgtgat ttagatattc aaataattca
      841 tctgatatag aatgttcaac tggattacca agcaatgcag aatacataaa tttcatcctc
      901 ctacgtttaa ttagtttact actaacataa agtacaagca ttacacagag ctaaccatta
      961 cctataagtc tttagagtat ctaaagactt aggtatacac ctaagtaact tacccaccaa
     1021 caataatgat aatatccatt gctaaaatta aaatcggcaa aaattttgaa attttcttca
     1081 taagtggact tcctttcagt ttttatttat tgtacaataa aaaaaaactg aattgatttt
     1141 tgttgggaaa gtgggaaaat atgaaatcaa aacttggtgc cacacttaga aaagttcgaa
     1201 aaggaaagca aattagtctg tgcttcgtgg cagatgaaca cctttcaaaa tcacaaatct
     1261 ctcgttttga gcgcggggag tcagagatat cgtgtatccg actgatcaat attctagaca
     1321 aattacacat tactttggat gagtttctta ttttacatga tgaagactat accaattccg
     1381 aaacatttgc taacctggta cagtatattc gtaagcaata ttcatcacaa aatatcaata
     1441 atatagcatg tttactttcc gacacttctg attacactct gaattctttt gagaaaacaa
     1501 tggtaaagtc cattttacac acaatggatt caagcatcat tccatcagat gatgaattac
     1561 ttcaactaac agattatctc tttaaagttg aaaaatgggg ctactatgaa atccttttgt
     1621 tgggtaactg tgtacgaaca attaactaca actcctactt cctattgaca aaggagatgt
     1681 taaataatta catttactct tcacggaaca aaactaataa acgaattgtc actcagcttg
     1741 ctataaattg tttcattctt agcatcaata aggaggaatt ttctaattgc tcctatttaa
     1801 ttgatgagat aaaaaccttg ttagataatg aattaaactt ctatgaacag acagtttttc
     1861 tctatgcaac aggttacttt gaatttaagc gccaattaga aactggagtt gaaaagatga
     1921 aacaagccat acaagttctt gatattttaa atgaagacaa gt
//
LOCUS       DAUDWO010000084         1813 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.085, whole genome shotgun sequence.
ACCESSION   DAUDWO010000084 DAUDWO010000000
VERSION     DAUDWO010000084.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1813)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1813)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1813
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.085"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            35..373
                     /locus_tag="VHC05_001722"
     CDS             35..373
                     /locus_tag="VHC05_001722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HEQ5402993.1"
                     /translation="MKSPFTVTNTMLNKVVEISKIIGNLELQVQKDLKLRKENRIQSI
                     HSSLAIEQNSLTVEQITAIIDGKRVLGNPREIREVKNAYEAYEEILTLTPYDESHFLK
                     MKEFQQYIYR"
     gene            397..1221
                     /locus_tag="VHC05_001723"
     CDS             397..1221
                     /locus_tag="VHC05_001723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine ligase"
                     /protein_id="HEQ5402994.1"
                     /translation="MGLGSDSLPVKISLFDVDTYLADSMQFHLEYILRLFPKSGVHYL
                     MPTFRGEAVDHRHLSQFYHSECEIEGDLHDVMNLVDRYIKFLVSEILRECRDSIFAIT
                     KDVSHLESFIDRKIPIITFEEACTILENEIDSLEYNDEHHFYVLTDVGEKKLMEHFEG
                     VVWVKNYPCKSVPFYQRFSTDHLFAYNADLLLGIGETVGCGERCETYEEVVENMNYLQ
                     VDASEYSWYLEMKKTRPMKSSGFGLGVERLIAWILKCDDVRKVQLISRENGIDYLP"
     gene            1241..1813
                     /locus_tag="VHC05_001724"
                     /pseudo
     CDS             1241..1813
                     /locus_tag="VHC05_001724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528392.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="LD-carboxypeptidase"
BASE COUNT          668 a          218 c          355 g          572 t
ORIGIN      
        1 tataaataag aaaaaagatt gtaaggagaa aatgatgaaa tcacctttta cagttacgaa
       61 taccatgtta aataaggtag tagagatttc taaaattatt ggtaatttag aattacaagt
      121 acagaaagat ttaaaattaa gaaaagaaaa tcgtattcag tctattcact catcactcgc
      181 tattgaacaa aattctttaa cagtagaaca aataacagcc attattgatg ggaaaagagt
      241 gttaggaaac ccccgtgaga taagagaagt aaaaaacgct tatgaagctt atgaagaaat
      301 tttaacgcta actccctatg atgaatcaca ttttttaaaa atgaaggaat ttcaacagta
      361 catttaccgg taacaacatc gtcaatcaca agtcctatgg ggttggggag tgattcgcta
      421 cctgtaaaaa tttccttatt tgatgttgat acctatcttg cagattcgat gcagtttcac
      481 ttagagtata tacttagact ttttccaaag tcaggagttc attacttaat gcctactttt
      541 agaggagaag cagtagatca tcgacattta tcgcaatttt atcatagtga gtgtgagata
      601 gagggagatt tacacgatgt gatgaattta gtggatagat atattaagtt tctggttagt
      661 gaaattctta gagagtgtcg agatagtatt tttgctataa caaaagatgt aagtcatttg
      721 gaaagtttta ttgatcgaaa gataccaatt attacgtttg aagaggcttg tactatattg
      781 gaaaatgaaa tagattcatt ggaatataat gatgaacatc atttttatgt gttaacagat
      841 gttggggaaa agaaattaat ggaacatttt gagggagtag tttgggtaaa aaattatccc
      901 tgtaaaagtg tcccttttta tcaaaggttc tcaacagatc atctatttgc ctataatgca
      961 gatttgttgt taggaatagg cgaaactgta ggttgtggag aaagatgcga aacatatgaa
     1021 gaagttgtag aaaatatgaa ttatttacaa gtagatgctt ctgaatatag ttggtattta
     1081 gaaatgaaaa aaacaagacc tatgaaatcc tcaggatttg gtttaggagt agagcgttta
     1141 atagcgtgga tattgaagtg cgatgatgtt cgaaaagttc aattaatcag tagagaaaat
     1201 gggattgatt atttaccata aaggaggaag aaaaatgaaa aattctatat taaagtatat
     1261 agactacgat ctatttaaac agaaatctcc tatctttatt ggatattctg acacaacagc
     1321 tcttgcttta gccttatata ataagactgg atgtataact tacctgtctc agagcgttat
     1381 ctctaatttt ggagagtttg aaccgtttaa tgaattaaat tatttctatt ttgacttcat
     1441 gcttcagagt aagtgcgaaa ccttaatggt acaaatacca gatgtttgga cggatgagtg
     1501 gataaattgg gaaacctatg aaaaaaccaa aaaaacaaat aaaaatgagt ggattatttt
     1561 taacaaaggt gaatttaacg gtactttgat cggaggaaat ctcgatacca ttgtaggaat
     1621 aataggaact gagtatatgc caaaaataac agaggatacc atactcttgt tagaagatgt
     1681 atatacggat ctaggaagat tatataggaa tttcacaacg cttgccttac atggtatttt
     1741 tgataaaata ggaggactta ttatttcaaa atttgaaaca ataggggaaa atagcgatgt
     1801 tattaatgat atc
//
LOCUS       DAUDWO010000085         1602 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.086, whole genome shotgun sequence.
ACCESSION   DAUDWO010000085 DAUDWO010000000
VERSION     DAUDWO010000085.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1602)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.086"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            24..944
                     /locus_tag="VHC05_001725"
     CDS             24..944
                     /locus_tag="VHC05_001725"
                     /EC_number="2.7.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003058858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I pantothenate kinase"
                     /protein_id="HEQ5402995.1"
                     /translation="MSNEFINFEKISRESWKTLHQKAKALLTQEELKSITSLNDNISI
                     NDVIDIYLPLINLIQVYKIAQENLSFSKSLFLKKDIQLRPFIIGISGSVAVGKSTTSR
                     LLQLLLSRTHPNSQVELVTTDGFLYPNQFLIEQGLLNRKGFPESYNMELLLDFLDSIK
                     NGQTAFAPVYSHDIYDIIPNQKQSFNNPDFLIVEGINVFQNQQNNRLYMSDYFDFSIY
                     IDADSSHIETWYIERFLSILKLAKRDPHNYYAQYAQLPRSEAIAFARNVWKTVNLENL
                     EKFIEPTRNRAELILHKSADHKIDEIYLKK"
     gene            998..1246
                     /locus_tag="VHC05_001726"
     CDS             998..1246
                     /locus_tag="VHC05_001726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S20"
                     /protein_id="HEQ5402996.1"
                     /translation="MEVKTLANIKSAIKRAELNVKANEKNSAQKSAMRTAIKAFEANP
                     SEELFRAASSSIDKAESKGLIHKNKASRDKARLAAKLG"
     gene            complement(1371..>1602)
                     /locus_tag="VHC05_001727"
     CDS             complement(1371..>1602)
                     /locus_tag="VHC05_001727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000491790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEQ5402997.1"
                     /translation="TDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTGGFGL
                     GLALAQQIVMSLKGNITVKDNDPKGSIFEVKL"
BASE COUNT          560 a          303 c          230 g          509 t
ORIGIN      
        1 ctgtcaaatg attaggagct accatgtcaa atgaatttat caactttgaa aaaatttcta
       61 gagagtcttg gaaaacatta catcaaaaag caaaagctct cctcacacaa gaggaactta
      121 aaagtattac tagcttaaat gataacatca gtattaacga tgtcattgat atctaccttc
      181 cattaattaa tctgatccag gtttacaaaa ttgcgcaaga aaatctttct ttttctaaaa
      241 gcctttttct aaaaaaagac attcaattaa ggccttttat tattggaatt tctggttcag
      301 tagctgttgg taaatcaaca actagtcgtc ttttacaact tttattatca cgaacgcacc
      361 ccaatagtca agtcgaactg gtaacgactg atggtttttt atatcctaat cagtttctta
      421 ttgaacaagg actgttaaat cgtaaaggat ttccagaatc ttataacatg gaacttctct
      481 tagattttct agattccatc aaaaatggtc aaacggcttt tgcacccgtc tattctcatg
      541 atatttacga tattatccca aatcaaaaac aatcatttaa taaccctgac ttccttatcg
      601 tcgaaggtat taatgttttt caaaatcaac aaaacaatcg tttatatatg agtgattact
      661 ttgatttttc tatttatatt gatgcagaca gcagtcacat cgaaacctgg tacattgaac
      721 ggtttctaag cattttaaaa ttagcaaaac gtgaccctca taattattat gcccaatatg
      781 cacaattacc tcgatctgag gctatagcat ttgcgcgcaa cgtttggaaa accgttaatt
      841 tagaaaatct tgaaaaattc attgaaccta cacgtaaccg tgctgaatta attttacata
      901 aaagtgctga tcataaaatt gatgaaattt acctcaaaaa gtgataaagg gttgccaaac
      961 gcatatattt tctatataat aatgtagtta gattaatttg gaggtgaaaa cattggcaaa
     1021 tattaaatca gctattaaac gcgctgaact taacgttaaa gcaaacgaaa aaaactcagc
     1081 acaaaaatca gctatgcgta ctgctatcaa agcatttgaa gctaacccat ctgaagagct
     1141 tttccgcgct gcttcttcaa gcatcgataa agctgaatca aaaggtttga ttcacaaaaa
     1201 caaagcaagc cgcgataaag cacgccttgc tgcaaaactt ggctaataaa tatccaatga
     1261 aaactccagc tggagttttt ttatacggta aaaactcaaa aaatacaata aagcgttgac
     1321 agttaaaaat aactttaaaa gggctgacct tattggtcgc cctttttagc ttatagtttg
     1381 acttcaaaaa tactaccttt aggatcatta tcctttactg taatatttcc ttttaaagac
     1441 atcacgattt gctgagctaa agccaacccc aagccaaatc cacctgtttg ccgtgttcta
     1501 gctttgtcaa ctcgataaaa acgatcaaaa atctttttct tttcttcatc tgttatccct
     1561 ggaccattat caataacaga aattaataaa tttttgtccg tt
//
LOCUS       DAUDWO010000086         1580 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.087, whole genome shotgun sequence.
ACCESSION   DAUDWO010000086 DAUDWO010000000
VERSION     DAUDWO010000086.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1580)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1580)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1580
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.087"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            124..351
                     /locus_tag="VHC05_001728"
     CDS             124..351
                     /locus_tag="VHC05_001728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Blp family class II bacteriocin"
                     /protein_id="HEQ5402998.1"
                     /translation="MEIKKLETFHQMTIEKLAKVEGGKNNWQANVSGVIAAGSAGAAI
                     GFPVCGVACGYIGAKTAITLWAGVTGATGGF"
     gene            364..561
                     /locus_tag="VHC05_001729"
     CDS             364..561
                     /locus_tag="VHC05_001729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class IIb bacteriocin, lactobin A/cerein 7B
                     family"
                     /protein_id="HEQ5402999.1"
                     /translation="MTMKELTINDMASISGGNAPGDAVIGGLGGLASGLKFCKLPHPV
                     LAGGCVVGFTVGGAYLGYTAN"
     gene            1100..1381
                     /locus_tag="VHC05_001730"
     CDS             1100..1381
                     /locus_tag="VHC05_001730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5403000.1"
                     /translation="MKILDIIFNLYDRKMIFLENVEKLGGYIVPFTLIILSVAYNFRH
                     PYPIWAAVLGGISLIVIFIYFILIVYLYLRYRYLVWKKIPEIKINSTEL"
BASE COUNT          515 a          201 c          343 g          521 t
ORIGIN      
        1 atttcatgat gaaaaaacgg ccttttaaga ttttgaagcc atgatactgt tctttatgat
       61 attctgtact agtcgaggtt gcaacgagac aaatttaaga attatgaaaa ggagttattc
      121 gatatggaga taaagaaact ggaaacattt catcaaatga ctatagaaaa gcttgccaag
      181 gttgagggtg gtaagaataa ttggcaggca aatgtcagtg gggttatcgc tgcaggtagt
      241 gctggagctg ctataggttt tccagtttgc ggtgtagcct gtggttatat tggagctaaa
      301 acagctatta ctctttgggc tggtgtaaca ggagctacag gcggcttcta gaggaaagaa
      361 aggatgacaa tgaaggaatt aacaattaat gacatggcta gtataagtgg aggaaacgct
      421 ccaggagatg ctgtaattgg tggtcttgga ggcttagctt ctggattgaa attttgtaaa
      481 ctgccacatc cagtattggc aggtggatgt gttgtaggat ttacagttgg tggagcatat
      541 ttgggatata cagcaaatta aatgatctat acgattttta ttattatgaa tgcgtctata
      601 atgtttttaa tcattgttga tgccattcat aaaaaaatgt tgataaatct ataccatatt
      661 tagtgttttt aattttcaat caattatccc tttcggaaaa atcggtaaac atgttatcta
      721 tcgtagcttt ggtagcgtca ttatttgttt ttatcgataa aagaaaatag tgattatgcc
      781 aatgaattta gatatcactc ttagcttttt aaaatacaaa agagtgaaat tagaatgaaa
      841 aagacttcaa aaatatggaa gtgctaaaaa aatggtctga ctatcataaa tggaggcgga
      901 aaagacggag caaatatctt tttgacaggg atggcaggtg ctgcgcaggg agtgacagtt
      961 tgtgctcaga caggcgtatt tatcccttgg caaggttata ttttgtgtgg agcagctggt
     1021 gctgctacaa atattatctg gcctcactaa atatataaat gactatctat cactgatata
     1081 taagtagtag aggagtggta tgaaaatttt agatattatt tttaacctat atgatagaaa
     1141 gatgatattt ctagaaaatg ttgaaaagct gggaggttac attgtccctt ttacccttat
     1201 catcttgagt gtagcctaca actttaggca cccttatcct atttgggctg ctgtactagg
     1261 aggtatatcc cttattgtga tctttattta ttttatactt attgtttatc tatatttgcg
     1321 ttatagatac ttggtgtgga aaaaaatacc agaaattaag attaattcta ctgagttata
     1381 atacaatcac atttaagggg aaaatggatg acttatacaa tatcagtact tatgatattt
     1441 aactttagag actaaagagt taaaagcaaa atgcgtattg aaaattggtt aaaaaagtta
     1501 taactgtctc tgataacagg aataataatt tgttcggtta tatttgctac cgatagagta
     1561 gaggaggtga agatatgcgt
//
LOCUS       DAUDWO010000087         1552 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.088, whole genome shotgun sequence.
ACCESSION   DAUDWO010000087 DAUDWO010000000
VERSION     DAUDWO010000087.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1552)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1552)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.088"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            216..1412
                     /gene="tuf"
                     /locus_tag="VHC05_001731"
     CDS             216..1412
                     /gene="tuf"
                     /locus_tag="VHC05_001731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014335040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HEQ5403001.1"
                     /translation="MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSSV
                     NQPKDYASIDAAPEERERGITINTAHVEYETATRHYAHIDAPGHADYVKNMITGAAQM
                     DGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDL
                     LSEYDFPGDDLPVIQGSALKALEGDTKFEDIIMELMDTVDSYIPEPERDTDKPLLLPV
                     EDVFSITGRGTVASGRIDRGTVRVNDEIEIVGIKEETKKAVVTGVEMFRKQLDEGLAG
                     DNVGILLRGVQRDEIERGQVIAKPGSINPHTKFKGEVYILSKDEGGRHTPFFNNYRPQ
                     FYFRTTDVTGSIELPAGTEMVMPGDNVTINVELIHPIAVEQGTTFSIREGGRTVGSGI
                     VSEIEA"
BASE COUNT          500 a          326 c          304 g          422 t
ORIGIN      
        1 taaggcatgg aattccaaag gaagtcgctg ccgtaagcac cacctaagga aagtatcaaa
       61 aaagactttt tcatctattt aaaaaaataa agaaatggca aaaaacataa aatacttgca
      121 ttttcattgt aatttgctac aatagtaagg taaagttaga ctgtatggcc taccgtctat
      181 ctataaaata tattttattg gaggcttttc ctaaaatggc aaaagaaaaa tacgatcgta
      241 gtaaacccca cgttaacatt ggtacaatcg gacacgttga ccatggtaaa actactttaa
      301 cagctgcaat cacaactgta ttggcacgtc gcttgccttc atcagttaac caaccaaaag
      361 attacgcttc tatcgatgct gctccagaag aacgcgaacg cggaatcact atcaacactg
      421 cacacgttga gtacgaaact gcaactcgtc actatgcgca catcgacgct ccaggacacg
      481 cggactacgt taaaaacatg atcactggtg ccgctcaaat ggacggagct atccttgtag
      541 ttgcttcaac agatggacca atgccacaaa ctcgtgagca catccttctt tcacgtcagg
      601 ttggtgttaa acaccttatc gtgttcatga acaaagttga ccttgttgat gacgaagagt
      661 tgcttgaatt agttgagatg gaaattcgtg accttctttc agaatacgat ttcccaggtg
      721 atgaccttcc agttattcaa ggttcagctc ttaaagctct tgaaggcgac actaaatttg
      781 aagacatcat catggaattg atggatactg ttgattcata cattccagaa ccagaacgcg
      841 acactgacaa accattgctt cttccagtcg aagatgtatt ctcaatcaca ggtcgtggta
      901 cagttgcttc aggacgtatc gaccgtggta ctgttcgtgt taacgacgaa atcgaaatcg
      961 ttggtatcaa agaagaaact aaaaaagctg ttgttactgg tgttgaaatg ttccgtaaac
     1021 aacttgacga aggtcttgca ggagacaacg taggtatcct tcttcgtggt gttcaacgtg
     1081 acgaaatcga acgtggtcaa gttattgcta aaccaggttc aatcaaccca cacactaaat
     1141 ttaaaggtga agtatatatc ctttctaaag acgaaggtgg acgtcacact ccattcttca
     1201 acaactaccg tccacaattc tacttccgta caactgacgt aacaggttca atcgaacttc
     1261 cagcaggtac agaaatggtt atgcctggtg ataacgtaac aatcaacgtt gagttgatcc
     1321 acccaatcgc cgtagaacaa ggtactactt tctcaattcg tgaaggtgga cgtactgttg
     1381 gttcaggtat cgtttcagaa atcgaagctt aattttaatt aagttcccag aatagcaatt
     1441 taagtcagac aacttaagtt tgaagaagcc cccaattcgg gggctttttg ctatcttaaa
     1501 ctccataaaa tgctgataaa taagaatgaa aagctttcag aaaaagagtt tt
//
LOCUS       DAUDWO010000088         1536 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.089, whole genome shotgun sequence.
ACCESSION   DAUDWO010000088 DAUDWO010000000
VERSION     DAUDWO010000088.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1536)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1536)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1536
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.089"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(9..443)
                     /locus_tag="VHC05_001732"
     CDS             complement(9..443)
                     /locus_tag="VHC05_001732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5403002.1"
                     /translation="MKRSKKASLLSVIVGMALAVIPIYIVNYDNELIVLLMSIFFNGI
                     IVSAFELIKTYDGLQEEYKKLTVDRWKNTILLAFNSLYFASILTNSLSNNLSTILSTN
                     RSDKVSAIFLTGCSILALLPFLLHRLIKREIEIENERKKLKK"
     gene            complement(715..1515)
                     /gene="sda3"
                     /locus_tag="VHC05_001733"
                     /gene_synonym="mf3"
     CDS             complement(715..1515)
                     /gene="sda3"
                     /locus_tag="VHC05_001733"
                     /gene_synonym="mf3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285611.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="streptodornase Sda3"
                     /protein_id="HEQ5403003.1"
                     /translation="MSKSNRRTWQGLVVILIAILTTFTTSTVTAARKIRNFPDTTEIL
                     LGTKATETPGILPFTGSYQLVLGDLDNLQRPTFAHIQLKDQDEPNIKRKGLKFNPPGW
                     HNYKLTDANGKTTWLMDRGHLVGYQFSGLNDEPKNLVTMTKYLNTGFSDKNPLGMLYY
                     ENRLDSWLALHPNFWLDYKVTPVYHKNELVPRQVVLQYVGIDENGDLLQIKLGSEKES
                     VDNFGVTSVTLDNVSPLAELDYQTGMMLDSTQNEEDSNLETEEFEEAA"
BASE COUNT          499 a          266 c          224 g          547 t
ORIGIN      
        1 ataagtaatt atttttttaa tttttttctt tcattttcaa tttctatttc tcgttttatt
       61 aacctatgaa ggaggaatgg aagtagtgct aaaatagaac aacctgtaag aaatattgca
      121 cttactttgt cagaacgatt agttgataaa atggtcgata aattatttga tagactattt
      181 gtcaaaatag aagcaaaata taatgaattg aaagccagta aaatagtatt cttccatcta
      241 tctacagtta gctttttata ttcttcctgc aaaccatcat atgttttaat aagttcaaaa
      301 gcggaaacaa ttatcccatt aaaaaaaata ctcattaaaa gaacgataag ttcattgtca
      361 taattaacaa tataaattgg tatcacagct aaagccattc caacaataac actaagtaac
      421 gatgcttttt tggacctttt cataaaatca ccctttttct ttcaatctac tatacatatt
      481 actcgattca atcatcctca acaaaggccg ttaaaacaga ctaatttctc aaagtcctat
      541 ttaagggact ttctaaatag acgttgtttt tttaaaaaat agcacagata gtagcctata
      601 ctaatttttc ttcaaaattt aactttatac aaattacccc aaatattaaa taaataatct
      661 aacatttggg ataatgttca caatctagat atttttatta agtataagtt tatgttaagc
      721 cgcttcttca aactcttcgg tttctaaatt actatcttct tcgttttgag ttgaatctag
      781 catcattcct gtttggtaat ccaattcagc taaaggagat acgttatcta atgtaactga
      841 tgttactcca aagttgtcta cactttcttt ttcactacct aacttaattt gaagtagatc
      901 tccattttca tcaattccaa catactgtag aactacttgg cgaggaacta actcattttt
      961 atgataaaca ggagtaactt tatagtctag ccagaagtta gggtgtagag ctaaccagct
     1021 atctaatcta ttttcataat agagcattcc taaaggattt ttgtcactaa agccagtatt
     1081 aagatatttt gtcattgtaa ctaggttttt aggctcgtca tttaagccgc taaattggta
     1141 accaactaaa tggccacggt ccattaacca agttgttttt ccattagcgt cagtcaattt
     1201 gtaattatgc cagccaggag gattgaattt aagtcctttt cgtttaatat taggctcatc
     1261 ttgatctttt agctggatgt gtgcgaaggt tggcctttgc agattgtcaa gatcgcccaa
     1321 aactaattgg tagctaccag tgaatggtaa gattcctggt gtctcagtcg ccttcgttcc
     1381 taacaaaatt tccgtggtat cagggaaatt tctaattttt ctggctgccg taacagtact
     1441 tgtggtaaaa gtggtgagaa tagctattaa aataacaact aaaccttgcc aagtacgacg
     1501 atttgattta gacatatcca tgtcctcctt ttatta
//
LOCUS       DAUDWO010000089         1495 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.090, whole genome shotgun sequence.
ACCESSION   DAUDWO010000089 DAUDWO010000000
VERSION     DAUDWO010000089.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1495)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1495)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1495
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.090"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..123
                     /locus_tag="VHC05_001734"
     CDS             <1..123
                     /locus_tag="VHC05_001734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation initiator family protein"
                     /protein_id="HEQ5403004.1"
                     /translation="EKQLAERLKDDNFVKKYARAKYYLSREGEMIYPIPGLLPK"
     gene            258..>1495
                     /locus_tag="VHC05_001735"
     CDS             258..>1495
                     /locus_tag="VHC05_001735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class A beta-lactamase-related serine hydrolase"
                     /protein_id="HEQ5403005.1"
                     /translation="MRKLLVAMLMTFFLTPLPVISTEKKLIFSKNAVYQLKQDVVQST
                     QFYNQLPSNPNLYQETCAYKDSDLTLPAGRLGVNQPLPIKSLVLNKESLPVFELADGT
                     YVEANRQLIYDDIVLNQVDIDNYFWTQKKLRLYSAPYVLGTQTIPSSFSFAQKVHATQ
                     MAQTNHGTYYLIDDKGWASQEDLVQFDNRMLKVQEMLLQKYNNPNYSIFVKQLNTQTS
                     AGINADKKMYAASISKLAPLYIVQKQLQKKKLAENKTLTYTKDVNHFYGDYDPLGSGK
                     ISKIADNKDYRVEDLLKAVAQQSDNVATNILGYYLCHQYDKAFRSEIKALSGIDWDME
                     QRLLTSRSAANMMEAIYHQKGQIISYLSNTEFDQQRITKNITVPVAHKIGDAYDYKHD
                     VAIVYGNTPFILSIFTNKST"
BASE COUNT          562 a          233 c          233 g          467 t
ORIGIN      
        1 gaaaaacaat tagcagaacg actaaaagat gataattttg tcaaaaaata tgctagggca
       61 aaatactatt tatcgcgtga aggagaaatg atttatccta ttccaggact attaccaaaa
      121 tgatgatgga caatattgta aaaaaaatag aagcatttct tgctttttct gataaaaaat
      181 tagcagagct gcaacaggaa aatcaaaaag ttaaagaaga aagtcagtat attcaaaaaa
      241 actagaaagg agtcaatatg agaaaattat tagtggctat gttaatgact ttttttctga
      301 ctcctttacc agtgattagt acagaaaaaa aacttatatt ttcaaaaaat gctgtttatc
      361 aattgaaaca agatgtcgtt caatcaacac aattctataa tcaactaccc tctaatccaa
      421 atctttatca agaaacgtgt gcttataaag acagtgattt aactctacca gcaggaagat
      481 taggtgtaaa tcaaccatta cctattaaat cgcttgtgct taacaaagaa tctttaccgg
      541 tttttgagtt agctgatggt acctatgttg aggctaatcg acaattgatt tatgacgata
      601 ttgtacttaa tcaagtagat atagataact atttttggac acaaaagaaa cttaggcttt
      661 attcagcccc ttatgtttta ggtacgcaaa caattccttc ttctttttca tttgctcaaa
      721 aagttcatgc cactcaaatg gcacaaacaa accatggaac ttattatctt attgatgata
      781 agggctgggc atcacaagaa gatctagttc aatttgataa ccgcatgtta aaagtccagg
      841 aaatgctctt acaaaaatat aataacccaa attattcaat ttttgtaaag caactcaaca
      901 cacaaacaag tgctggtatt aatgctgata aaaaaatgta tgctgcaagt atctcgaagt
      961 tagcaccact ttatattgtt caaaaacaat tacaaaagaa gaaattagca gagaataaaa
     1021 ctttgactta tactaaagat gttaatcatt tttatggaga ctatgatcca ttgggaagtg
     1081 gtaaaattag taaaatagct gataataaag attatcgtgt tgaagaccta ctgaaagctg
     1141 tagcacaaca atcggataat gtagcaacta atattttagg ttattatcta tgtcatcagt
     1201 atgataaagc tttccgctca gagataaaag ctttatcagg tatcgattgg gatatggagc
     1261 agcgattatt aacttctcgt tcagctgcaa atatgatgga agctatttat catcaaaaag
     1321 gccaaattat ttcttacctt tcaaataccg aatttgatca acaacgtatc acaaaaaata
     1381 ttactgttcc agttgcacat aaaattggtg atgcttatga ttataaacat gacgttgcta
     1441 ttgtttacgg taatactcca tttattttgt ctatttttac aaataaatca accta
//
LOCUS       DAUDWO010000090         1468 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.091, whole genome shotgun sequence.
ACCESSION   DAUDWO010000090 DAUDWO010000000
VERSION     DAUDWO010000090.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1468)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1468)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1468
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.091"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            237..971
                     /locus_tag="VHC05_001736"
     CDS             237..971
                     /locus_tag="VHC05_001736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="coenzyme F420-0:L-glutamate ligase"
                     /protein_id="HEQ5403006.1"
                     /translation="MNLSIFGLKNIPYLKEGDSIEKLIEESIKTSEFFIEDNDVLCIA
                     SKVVSVAEGQVMSLNEIQVSDVAKEIHRNIPRKDPRIIEIMLNLVNRDLSRLDIKKNY
                     IGCRLENGLKLTSGGIDRKSVDEVFLLPNNPDASAKRISEYLKKSLGKNVAVVITDSD
                     GREDKRGATQVAIGIYGIHPLRKTEVIDSQGETIKFQEETLCDMIAACAGLVMGQRGT
                     GIPAVLIKGLDYKWFENTSIKEALNE"
     gene            964..>1468
                     /locus_tag="VHC05_001737"
     CDS             964..>1468
                     /locus_tag="VHC05_001737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dehydrogenase"
                     /protein_id="HEQ5403007.1"
                     /translation="MSRNQDCKNILIIGFGKIGKIKAYKWLSRGYEVYVKDLKFSSMK
                     YLNTNSDVLDDLSRQYFTIEICTPTNHHLMLLKTVITRYVYSYISIEKPLCNRLEDLE
                     EMKSLVGSHPHLAKKMFASEQYFFSKILEKLLQVDCFSLDKIKEITVNFSKDRIEDNE
                     NGRFLDKE"
BASE COUNT          557 a          173 c          293 g          445 t
ORIGIN      
        1 gaaaaaatat atttactata ttcactgtaa gaactatgtt aacaatgatt taggaataca
       61 ttatgtagaa ctaggtaaag gaattatcga ttataaaaca atcattcatg aaatccatga
      121 acattttata gacttaattt ttagtttaga agtacatgaa aaagaaatag acaaaaaggc
      181 agaagtagtg aggaagtctt atctgacact aaatgagtat attaatggag gctaaaatga
      241 atttgagtat atttggttta aagaatattc cttatttgaa agaaggggat agtatagaaa
      301 agcttattga agaaagcatt aaaacttcag aattttttat cgaagacaat gatgtgcttt
      361 gcatagcttc taaagttgta tctgtcgcag aaggccaggt gatgtcttta aacgagatac
      421 aagtgagtga tgtagcaaaa gaaatccaca ggaatattcc tcgtaaagat cctagaataa
      481 ttgaaattat gctaaattta gtcaatagag atctgtcacg tttagatatc aaaaaaaatt
      541 atattggttg tcgcttggaa aatggtttaa agttgacaag tggtggaatc gatagaaaat
      601 cagtagatga agtatttctt ttacctaata atccggatgc ttctgcaaaa agaatttcgg
      661 aatatcttaa aaaatcactt ggaaaaaatg ttgcagttgt tataacagat agtgatggta
      721 gagaggataa aagaggtgct actcaagtag caattggtat ttatggtatt catcctttga
      781 gaaaaacaga agtaatagat tcacaaggag agacaataaa attccaagaa gagactttgt
      841 gtgatatgat tgcagcttgt gctggcttag taatggggca acgtggaact ggaattccag
      901 ctgtcctcat taagggcttg gattataaat ggtttgaaaa tactagtatt aaggaagcgt
      961 taaatgagta gaaatcagga ctgtaagaat attctaatca ttggttttgg aaaaattggg
     1021 aaaattaaag cgtacaagtg gctatcacgc ggatatgagg tatatgtcaa agatttaaaa
     1081 ttctccagca tgaaatacct taatacaaat agtgatgtgt tggatgattt atcacgacaa
     1141 tattttacta ttgagatttg tactccgaca aatcaccacc ttatgctatt gaaaaccgtt
     1201 ataacaaggt atgtctattc ttatattagc attgaaaaac cactgtgtaa caggttagaa
     1261 gatttagaag aaatgaagtc gctagtagga agtcacccac atctagcaaa aaaaatgttt
     1321 gccagtgaac aatacttctt ttcgaaaatt ttggaaaaac tgttacaagt agattgtttc
     1381 tctctagata aaatcaagga aataacagtt aatttttcta aagataggat tgaggataac
     1441 gagaatggga gatttttaga taaagaga
//
LOCUS       DAUDWO010000091         1399 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.092, whole genome shotgun sequence.
ACCESSION   DAUDWO010000091 DAUDWO010000000
VERSION     DAUDWO010000091.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1399)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1399)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.092"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            573..854
                     /locus_tag="VHC05_001738"
     CDS             573..854
                     /locus_tag="VHC05_001738"
                     /inference="COORDINATES: protein motif:HMM:NF013753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEQ5403008.1"
                     /translation="MTVLNYVNAGDAKSIHNHLFHYTRQVRRHVKVITIGILSAHYYE
                     ITMLFLQAKIILDCFHIPQRLRQAITRFRIRIINTSAIKPIAYRTLKLY"
     gene            complement(1305..1392)
                     /locus_tag="VHC05_001739"
     tRNA            complement(1305..1392)
                     /locus_tag="VHC05_001739"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1356..1358),aa:Ser,seq:gct)
BASE COUNT          502 a          281 c          150 g          466 t
ORIGIN      
        1 aatagaatac agtaaaatca atttaaatac ataaaattac acaaaaagtt tgaaaattat
       61 atcttaagaa cgctataagt aatacaaaat tgtttatctt cactcagaca ccttatcctt
      121 cttagaatga atttttagtt acttatccac aggttaataa cttcttttcg cctaaaacat
      181 tatccacaat agtgacattt tctattatca gtttatgcct ttccattttc caattagaat
      241 attagacatc ttttttgacc ttatcattat tagtataagt atagtcaaac cttctttttt
      301 tataagctaa ctatcgaaaa ctggtcatct ataaatctta gtattccatc actcaatcac
      361 aattcataaa gactcgcaaa ctttcacaac ttttaattct atactttctg tagtaggtaa
      421 atccacctca aagattatag agtcttttaa acatatgtaa aaagttccat atgacgatct
      481 ataatgaaaa gcgaccaaac tatcatttca gaaagactca tataaaatca tccgattata
      541 gtataatttc actaggaaac taaaacctta gcatcacggt tttaaattat gtaaatgctg
      601 gggacgcaaa aagcattcat aaccatctct ttcattatac cagacaggtt agaaggcatg
      661 tcaaagttat taccataggc atactcagtg cccactacta tgagattact atgctttttc
      721 tacaggctaa aattatcctc gattgttttc atatccccca acgtcttaga caagctataa
      781 ctcgctttcg tatccgaatc ataaatactt ctgctataaa acctatcgcg tatagaactc
      841 tcaaacttta ctgaaaactc atacagcatg attcacggaa gctcatcaat aatagcttta
      901 ttgcccaatt tttcgtacgc ccataactaa tatctagaaa agaaaagctc ttactcacaa
      961 gatctctgaa tttcaataat tattcctaac tctatcaact cttactcttc ccatttttca
     1021 gacaattttt aaaatttttc taaaagaaaa gaacaagatt agcaatatac ttaaactcaa
     1081 ctactctaag gccaaattag aaacagtcaa caaccttatc aaagccatca agttaaacgt
     1141 tttactcctc ttagttatcg aaataatgaa cgatttaaat attctattta gttggttttg
     1201 aagattacaa aaaaaaagac gataaccgtc ttctttcccc tttatttata attcatctat
     1261 taatatgttt catttaacat attaaccaaa atatgtttac aaaacggaga ataagggatt
     1321 cgaacccttg cgccagttac ccgacctaac gatttagcaa accgtcctct tcagcctctt
     1381 gagtaattct ccaaatata
//
LOCUS       DAUDWO010000092         1360 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.093, whole genome shotgun sequence.
ACCESSION   DAUDWO010000092 DAUDWO010000000
VERSION     DAUDWO010000092.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1360)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1360)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1360
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.093"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(<1..792)
                     /locus_tag="VHC05_001740"
     CDS             complement(<1..792)
                     /locus_tag="VHC05_001740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2142 domain-containing protein"
                     /protein_id="HEQ5403009.1"
                     /translation="MQQSMTKVKYLWKENNNYIYSTFLTLLLTVILYANSLNLPLKFI
                     SLLFVVSTLLIVFLPKKLEVATIIFILVFGTISAIISPINDIPDEYVHYSRTVYISEG
                     DINLTNNNKKLRISKDVDKLIKQSGKTFITSNLKATKHSTREYSYPYIKGTNAYYSFS
                     YIPQALGILVGNALDLPILLTYYFGRLCNLISYAMLAFIAIKLSGSFKQVIAVVTLLP
                     MNIYLAASFNQDGFAIGLVLVTIGLFINLLSSKDKSNYNTKFFLYL"
     gene            complement(773..>1360)
                     /locus_tag="VHC05_001741"
     CDS             complement(773..>1360)
                     /locus_tag="VHC05_001741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="HEQ5403010.1"
                     /translation="KYAIELMTTLGEVALGSQTIFNILFMPAFVMNLLILFFRPHITQ
                     MAIALIRGQIKEFNKIQVQLFAYLGVFSLIALVGSGLFGIPFLSILYGTNLTDYWVDF
                     MLIMLGGSIGSFATVIDNILTAMRKQQLLLIPYTGGFLISLLITNLFVMKYHILGAAL
                     SFLITMLVWLGLSIMIYLFIMNRFKKGRVNATIYD"
BASE COUNT          530 a          213 c          189 g          428 t
ORIGIN      
        1 taaataaagg aagaatttgg tattatagtt agatttatct tttgatgaga gcaagttaat
       61 aaacaatcca attgttacta aaactaaacc gatagcaaag ccgtcttgat taaaagatgc
      121 tgctaaataa atgttcatag gtagtaaagt aacaacagct atcacttgtt taaaagaacc
      181 agacaacttg atagctataa aagcaagcat agcgtagcta ataaggttgc acaatcttcc
      241 gaaataatat gttaaaagta taggtaaatc cagcgcattt cctactaaaa tacccaaagc
      301 ttgtggtata taagaaaaac tataatatgc attagttcct ttgatgtaag gatagctata
      361 ctctcttgtg ctgtgtttag ttgctttcaa gtttgatgtt ataaatgttt ttcctgactg
      421 tttaataagc ttatcaacat ctttggatat tcttaacttt ttgttattgt tggtaagatt
      481 aatatcacct tctgagatat aaactgtcct tgaataatga acatattcat caggaatatc
      541 atttataggt gatatgatag cagatatcgt tccaaatact aaaataaaaa tgatcgtagc
      601 aacctctaac ttttttggta aaaacactat cagtaaagtg ctcaccacaa aaagaagact
      661 aataaatttt aaaggtagat ttaaactatt ggcatataaa ataactgtca gaagtaatgt
      721 caaaaaagtc gaataaatat agttattatt ttctttccaa agatatttaa ctttagtcat
      781 agattgttgc attaactctt cccttcttaa atctattcat aataaataga taaatcataa
      841 tggataatcc caaccaaacc aacattgtta ttaaaaagct caaagcagct cctaaaatat
      901 gatatttcat aacaaaaaga ttggtaatta ataacgaaat caaaaatcct cctgtatatg
      961 gaataagaag aagttgctgt tttctcatag cggttaagat attatcgata actgtcgcaa
     1021 aactaccaat cgagcctcct agcataatca acataaaatc tacccaataa tccgtaaggt
     1081 tagtaccata tagtattgat aaaaagggaa taccaaacaa accacttcca actaacgcta
     1141 tcagtgaaaa aactcctaaa taagcaaaca attgaacttg tatcttatta aactctttta
     1201 tttgacctct gattaaagca atagccatct gtgtaatatg aggtctaaaa aataaaatta
     1261 gcaaattcat aacaaaggct ggcataaata aaatattaaa aattgtttga gagcccaaag
     1321 caacttcacc taaagtcgtc attagttcaa tagcgtattt
//
LOCUS       DAUDWO010000093         1322 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.094, whole genome shotgun sequence.
ACCESSION   DAUDWO010000093 DAUDWO010000000
VERSION     DAUDWO010000093.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1322)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.094"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(23..1084)
                     /locus_tag="VHC05_001742"
     CDS             complement(23..1084)
                     /locus_tag="VHC05_001742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HEQ5403011.1"
                     /translation="MFPIAFWDVIHSFIVYFIVFYISFLKNNYHSNIIIMIFSIVAGT
                     MVLLLIQAFNYDFSHLRKKKLNQRTRKIISIANFSMILYFITIPMIDFIEEVENINFT
                     HYQEMITAIYFLLFICFVNLLDRNLRQELQKQVVLQKELQLQNMARYSKQIEGLYQNI
                     RSFRHDYANILTSLKIGIDCKDIEMISSIYHKVLKDSGKVLRGEKFNLARLRNINDLP
                     LKSLLFVKLSEAQRLSIPVSIEIGEPISIKNIELIDFLTLVSILIDNAIEGAAESGIV
                     LCFFEQFGKQILIVQNDTFEKQINLSTIFERGVSSKGNNRGVGLSNVREILESYPTVT
                     LKTVSNHFVFKQILEIEIL"
BASE COUNT          503 a          210 c          176 g          433 t
ORIGIN      
        1 gataaaaaag aaaagtatta cattatagga tttctatttc tagaatctgt ttaaaaacaa
       61 aatgattact tactgttttg agggtaacag tgggatatga ttctaatatc tccctgacat
      121 ttgataaacc aactccccta ttatttcctt ttgaagaaac acctcgctca aaaatcgtgg
      181 aaagattaat ctgtttttca aaagtatcat tttgaacaat taatatctgt ttaccaaatt
      241 gttcaaaaaa acaaagaact atccccgact ctgctgcacc ttcgattgca ttatctatca
      301 agatagaaac aagggttaaa aaatcgatta actcaatgtt ttttatagaa atcggttccc
      361 caatttctat agatacaggt atggataagc gttgagcttc tgataatttt acaaacagta
      421 aacttttcag aggaaggtcg tttatatttc tcagccttgc tagattgaat ttttctcccc
      481 ttaaaacctt ccctgaatct ttcaacacct tatgataaat gcttgaaatc atttcaatat
      541 ctttgcaatc aatgcctatt ttcaagcttg ttaaaatatt tgcataatca tgtctaaaac
      601 ttctgatatt ttgatacagt ccttcgattt gcttactata gcgagccata ttctgtaatt
      661 gtaactcttt ttgtagaaca acttgctttt gtaattcttg gcgtaagttc cgatccaata
      721 aatttacaaa acaaataaat aaaagaaaat aaattgctgt tatcatctct tgatagtgcg
      781 taaaattaat attttcaact tcttcgataa aatctatcat tggaatggta ataaagtaca
      841 atatcatgct aaagttggca atagatataa tctttctagt acgttgattt agtttctttt
      901 ttcttaaatg actaaagtca taattaaaag cttgaatcag cagcaaaacc atagtaccag
      961 caacaataga aaaaatcata ataatgatat ttgaatgata gttatttttt agaaaagaaa
     1021 tataaaaaac aataaagtaa acaataaaac tatgaattac atcccaaaaa gcaataggaa
     1081 acaaactata aaataaaaga agtgaaccat tgacctttcg tcttgcaata tagcgagtgt
     1141 ataacaaaaa aaataatgga taaagtaata gtcctcctaa aaaacccact gatagtaggt
     1201 tggataaaga agtagataaa agagaacaga tataaaatgt taaaattcct aataggctct
     1261 tttttgtgtc catacgatag ccaaatattc tcgcatgaat taacaatagc acaaccacat
     1321 ta
//
LOCUS       DAUDWO010000094         1321 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.095, whole genome shotgun sequence.
ACCESSION   DAUDWO010000094 DAUDWO010000000
VERSION     DAUDWO010000094.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1321)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1321)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1321
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.095"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(650..>1321)
                     /locus_tag="VHC05_001743"
     CDS             complement(650..>1321)
                     /locus_tag="VHC05_001743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1542 domain-containing protein"
                     /protein_id="HEQ5403012.1"
                     /translation="KAYRPGEGVKARKEAAKANLEKVAKETKALISGDRYLSETEKAV
                     QKQAVEQALAKALGQVEAAKTVEAVKLAENLGTVAIRSAYVAGLAKDTDQATAALNEA
                     KQAAIEALKQAAAETLAKITTDAKLTEAQKAEQSENVSLALKTAIATVRSAQSIASVK
                     EAIDKGITAIRAAYVPNKAVAKSSSANHLPKSGDANSIVLVGLGVMSLLLGMVLYSKK
                     KESKD"
BASE COUNT          411 a          260 c          219 g          431 t
ORIGIN      
        1 aataataatt gattaatata gaaacaatta tgatctaata tactgaattt tataatagat
       61 tctatcgata actatgtgta aacaatcaag tagaaatgtc tttattaagc gaatcaatca
      121 agtttgtaga gtaaatacta gactagattt catgtagaaa ttagtaaaag ttaggagatt
      181 ttttggtggt ttcaaacgat aacatcatct tcttataaca agaacttcac tcagagataa
      241 actattctaa tactttagta gcctcttttg agcttgtagc acgaaaattc gctcgaactg
      301 atttaaaata ggcattttat ctgctcgctt gatccctact gcgcgaccaa gaaacctttt
      361 attcactaga acaattaacc cttaaaacca aggaggaagt ccactggtag aactaccatc
      421 accttcacag taatcttaat tatcaaacac ccataactaa atgagtcatc gtttgaacaa
      481 aaaacgcctt ataaattctg tacagaaaac tgttgccttt tcaattgaac tttgaaatgt
      541 tttcaataca atccgttctt gggcccttac gatccaaaaa accaaggtga tttcaaaatc
      601 accttggttt gaaaatatag tagaaagcaa tttggataaa gccaggttct tagtctttac
      661 tttctttttt cttgctataa agcaccatac ctaaaagaag agacataact cctaagccaa
      721 caagaacaat tgagtttgca tcacctgatt ttggaagatg gttcgctgac gatgattttg
      781 cgactgcctt attaggcaca taggctgcac ggatagcagt aataccttta tctattgctt
      841 ctttcacaga cgcaatagat tgtgctgaac gaacagtcgc aatagccgtc ttaagcgcta
      901 atgatacatt ttctgattgt tcagcttttt gagcttcagt caatttagca tcagttgtaa
      961 tcttagcaag tgtttctgcc gcagcttgtt taagagcttc aatagcagct tgtttcgctt
     1021 cgttaagagc agctgttgct tgatcagtat ctttagctaa accagcaaca tatgctgaac
     1081 ggatagctac agtaccaaga ttttctgcca acttaacagc ttcaactgtc ttagcagcct
     1141 caacttgacc aagtgctttc gcaagagctt gctcaacagc ttgtttttgg actgcttttt
     1201 cagtttcgct caagtaacgg tctcctgaaa taagagcttt agtttcttta gctacttttt
     1261 caagattagc tttagcagct tctttacgtg ctttaacacc ttcacctgga cggtaagctt
     1321 t
//
LOCUS       DAUDWO010000095         1315 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.096, whole genome shotgun sequence.
ACCESSION   DAUDWO010000095 DAUDWO010000000
VERSION     DAUDWO010000095.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1315)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1315)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1315
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.096"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(38..1264)
                     /locus_tag="VHC05_001744"
     CDS             complement(38..1264)
                     /locus_tag="VHC05_001744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015055967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HEQ5403013.1"
                     /translation="MKRHFLLLTFYLFLTGLTAGLVAFILTKAIHLIQSLSFGFSQGS
                     FSTMIASVPPQRRALSLLFAGLLAGLGWHLLAKKGKDIQSIQQIIQDDISFSPWTQFW
                     HGWLQLTTVSMGAPVGREGASREVAIALTSLWSQRCNLSKADQKLLLACASGAALGAV
                     YNAPLATILFILEAILNRWSLKNIYAACLTSYVAVETVALLQGRHEIQYLMPQQHWTL
                     GTLIWSVLAGLILSLFAHAYKHLLEHLPKADAKSQWFIPKVLIAFSLIAGLSSFFPEI
                     LGNGKAGLLFFLHEEPHLSYISWLLVAKAVAISLVFASGAKGGKIAPSMMLGGASGLL
                     LAILSQYLIPLSLSNTLAIMVGATIFLGVINKIPLAAPVFLVEITGQSLLMIIPLALA
                     NLIFYFSYQFYRFILK"
BASE COUNT          454 a          247 c          294 g          320 t
ORIGIN      
        1 tcatccgaac ctttttatta aaaaagtaat taactaatca tttaaggatg aaacgataaa
       61 actgatagct aaaataaaaa atgaggttag ctaatgctaa agggataatc attagtaacg
      121 attggcctgt aatttcaact agaaaaactg gtgccgccaa gggtatctta ttgatcacac
      181 ctaaaaagat tgttgcacca accataatgg ctaacgtatt tgatagagac aaaggaataa
      241 ggtactgact aaggatagct agtagtaagc cactagcacc tccaagcatc atagaaggag
      301 caattttacc cccttttgct ccagaagcaa aaactaaaga gatagcgaca gctttggcaa
      361 caagtagcca gctaatatag ctcagatgtg gttcttcatg gagaaaaaag agtaatccag
      421 ctttgccatt tcctaaaatc tctgggaaga aactgctgag tcctgcgata aggctaaaag
      481 cgatgagaac tttcggaata aaccactgac ttttggcatc agccttagga aggtgttcca
      541 gaagatgttt gtaagcgtga gcaaagaggg aaaggataag accagccagg acggaccaaa
      601 taagggttcc tagcgtccaa tgttgctgag gcattaggta ttgaatctca tgtcggcctt
      661 gtaataaagc aactgtttcc acagccacat agctcgttag gcaggcagcg tatatatttt
      721 taagggacca acggttaaga atagcttcca agataaataa aatagtggct aagggagcat
      781 tgtagacagc accaagggca gcgccagaag cgcaagctaa taaaagtttt tgatcggctt
      841 ttgacaagtt acatctttgg ctccaaagag acgtcaaggc aatagcgact tcccgcgaag
      901 ctccttctcg gccgacagga gctcccatag atacggtcgt taattggagc caaccatgcc
      961 aaaactgtgt ccagggacta aatgagatgt catcttgaat gatttgctga atagattgaa
     1021 tgtcctttcc ttttttagcc aataggtgcc acccaagacc tgcaagaagt ccagcaaaga
     1081 ggagtgaaag agctcgtctt tgtggtggaa cactagcaat catggtgcta aaagaacctt
     1141 gactgaatcc aaaactgagg gactgaatca ggtgaatggc ttttgttaag ataaaagcaa
     1201 caaggccagc tgttaaacct gttaaaaaga ggtaaaaggt caagagtaaa aagtgtcgtt
     1261 tcataagact attataacaa aagttaagaa aagagactga tagattatca gtctc
//
LOCUS       DAUDWO010000096         1168 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.097, whole genome shotgun sequence.
ACCESSION   DAUDWO010000096 DAUDWO010000000
VERSION     DAUDWO010000096.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1168)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1168)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.097"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            96..>1168
                     /gene="tilS"
                     /locus_tag="VHC05_001745"
     CDS             96..>1168
                     /gene="tilS"
                     /locus_tag="VHC05_001745"
                     /EC_number="6.3.4.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="HEQ5403014.1"
                     /translation="MNLLHFLYLFQDKLKIRIGIAHVNHKQRSESDSEEAYLKCWAKK
                     HDIPIYVSNFEGIFSEKAARDWRYAFFKSIMLKNNYSALVTAHHSDDQAETILMRLIR
                     GSRLRHLSGIKSVQPFANGQLIRPFLTFSKKDLPEIFHFEDSSNRELSFLRNRVRNNY
                     LPLLKQENPRFIQGLNQLALENSLLFQAFKELTNHITTTDLTEFNEQSKSIQYFLLQD
                     YLEGFPDLDLKKSQFTQLLQIIQTAKQGYYYLKKDYYIFIDKFSFKITKIVPKTELVK
                     EEKMLEYDSNLCYRDYYFSFMPKSNEDQGQVSIPLFSLSSIKLRSRQSGDYISFGHFS
                     KKIRRLFIDEKFTIAERQNAIIG"
BASE COUNT          439 a          160 c          172 g          397 t
ORIGIN      
        1 tgacctatca agaaattttt aatgaaataa aaaataaagc ctactttaaa aatcatagac
       61 atgttttaat agccgtatct ggtggagtag attcaatgaa tttattgcac tttttatacc
      121 tgtttcaaga caaattgaaa attcgtattg gtattgctca tgttaatcac aaacaaagat
      181 cagaatcaga ttcagaagaa gcttatttaa agtgttgggc taaaaaacat gacataccta
      241 tttatgtttc taattttgaa ggaatatttt cagaaaaagc agcacgtgat tggcgctatg
      301 ctttttttaa aagtattatg ttaaaaaata actattcagc tttagtaaca gctcaccatt
      361 cagatgatca agcagaaact attttgatga ggctaattag aggaagccga ttgaggcact
      421 tgtcgggtat aaaaagcgtg caaccatttg ccaatggtca acttataaga ccttttttaa
      481 ctttctcaaa aaaggacttg ccagaaattt ttcattttga agattcttca aatagggaat
      541 tatcattttt aagaaataga gttagaaata attatttacc attgttaaag caggaaaatc
      601 ctaggttcat tcagggatta aatcaattag cacttgaaaa tagcttactt tttcaagctt
      661 ttaaggagct aacaaatcat attactacca ctgatttaac agaatttaat gagcaatcta
      721 agtctattca atactttttg ttacaagatt atttagaagg ttttccagat ttagatttaa
      781 aaaaatctca atttactcaa ttattgcaaa ttatccaaac tgctaaacaa ggctattatt
      841 atctcaaaaa agactattat atattcattg ataaattctc ttttaaaatt acaaaaatcg
      901 ttcctaagac tgagttagtt aaagaagaaa aaatgttaga atacgatagt aacttatgct
      961 acagagatta ttatttttca tttatgccaa aaagtaacga agatcaagga caggtaagta
     1021 tacctttatt tagtttatcg tctattaaat taagaagtcg ccaatctgga gattatattt
     1081 cttttggtca cttttcaaaa aaaataagac gtttatttat agatgaaaaa ttcacaatag
     1141 ctgaacgtca aaatgctatt attggaga
//
LOCUS       DAUDWO010000097         1153 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.098, whole genome shotgun sequence.
ACCESSION   DAUDWO010000097 DAUDWO010000000
VERSION     DAUDWO010000097.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1153)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1153)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1153
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.098"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            163..1122
                     /gene="nrdF"
                     /locus_tag="VHC05_001746"
     CDS             163..1122
                     /gene="nrdF"
                     /locus_tag="VHC05_001746"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HEQ5403015.1"
                     /translation="MTTYYEAINWNEIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDW
                     RKLSLQEKDLVGKVFGGLTLLDTMQSETGVEAIRADVRTPHEEAVLNNIQFMESVHAK
                     SYSSIFSTLNTKKEIEEIFEWTNNNEFLQEKARIINNIYANGDALQKKVASTYLETFL
                     FYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLGFNELPEDEQENFR
                     DWMYDLLYQLYENEEKYTKTLYDGVGWTEEVMTFLRYNANKALMNLGQDPLFPDTAND
                     VNPIVMNGISTGTSNHDFFSQVGNGYLLGSVEAMSDDDYNYGL"
BASE COUNT          361 a          220 c          201 g          371 t
ORIGIN      
        1 ggacaatcgc tttaggcgtt ccgcctaaac cactcactga ctcattcgtt acccttttga
       61 atctatttaa acttattatt accggtagaa ctttggtcgg ttctactggt ttatctcgat
      121 atccttaacg cactttacta ctctttagga gatcattttt ctatgactac atattatgaa
      181 gcaattaact ggaatgaaat cgaagacgtc attgacaagt caacttggga aaagttgacc
      241 gaacaatttt ggcttgatac ccgtatccct ttatcaaatg acttagacga ttggcgcaaa
      301 ctttctcttc aagaaaaaga tcttgttggc aaggtttttg gaggattaac cctacttgat
      361 accatgcaat cagaaactgg tgtcgaagct attcgtgctg atgttcgcac tcctcacgaa
      421 gaagctgtct taaacaatat tcaattcatg gaatctgttc acgctaaatc ttattcgtct
      481 atcttttcaa ccttaaacac caaaaaagaa attgaagaga tctttgagtg gactaataat
      541 aatgagtttc ttcaagaaaa agcacgtatt atcaataaca tttacgctaa tggagatgcc
      601 ttacaaaaga aagttgcctc aacatatctc gaaactttcc ttttttattc tggctttttc
      661 acccctcttt actatttggg aaataataag ctagcaaatg ttgctgaaat cataaaacta
      721 attattcgtg atgaatctgt acatggtact tatatcggtt acaaattcca gcttggtttt
      781 aacgaactac cagaagatga gcaagagaat tttcgtgatt ggatgtatga cctcctttat
      841 cagctgtatg aaaatgaaga aaaatacacc aaaacgcttt atgatggcgt agggtggact
      901 gaagaagtta tgaccttttt acgctacaat gctaacaaag ctcttatgaa tttaggacaa
      961 gatcctttat tcccagatac tgcaaacgat gttaacccaa ttgttatgaa tggtatttca
     1021 acaggaacat caaaccatga ctttttctca caggtaggga atggctatct tcttggttct
     1081 gtagaagcta tgtctgatga cgattataat tatggactct aatagtgctc acgagactga
     1141 taatctatca gtc
//
LOCUS       DAUDWO010000098         1132 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.099, whole genome shotgun sequence.
ACCESSION   DAUDWO010000098 DAUDWO010000000
VERSION     DAUDWO010000098.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1132)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.099"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..570
                     /locus_tag="VHC05_001747"
     CDS             <1..570
                     /locus_tag="VHC05_001747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 lantipeptide synthetase LanM"
                     /protein_id="HEQ5403016.1"
                     /translation="SWKINKNYNYFKIAKSAIDFENTRISDGNWIDFRNKGKRSELGM
                     PEPIYWCHGATGIGLTRYRESKWLNDKELKNNYEMAKQTVLNNGYLNSDCLCHGKMGN
                     MELFMNLDDSLKNEVDIEGIILNIVRNSQKFGWESGLPQHTRVFNMMVGEIGIAYQLL
                     RYISNYEVPSLLLLDVPKGSIENEKDYTD"
     gene            548..>1132
                     /locus_tag="VHC05_001748"
     CDS             548..>1132
                     /locus_tag="VHC05_001748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="HEQ5403017.1"
                     /translation="MKKITPIEQTTPTECGLCCLYMMLDYFDISETYFKLKQQVNLGR
                     NGLSIKNISDIASIYGVTCKTYRFSKYPENLPVMVFVSDSHFVILEDIRDDAFTIVDP
                     AVGKYVLAKNEFFELSPKFYTEFFYDKATNSSKKIAKRGLVGRNVKEMIFVNRKDTFL
                     TILYTLIFQIITVSIPFFIRGIIDGNWVFLKKFGY"
BASE COUNT          400 a          134 c          210 g          388 t
ORIGIN      
        1 tcatggaaaa tcaataaaaa ttataattat tttaaaatag cgaagtcagc tattgatttt
       61 gaaaataccc gtatttctga tggaaattgg attgatttta gaaataaagg aaaacgttca
      121 gagttaggaa tgccagaacc tatttattgg tgtcatggtg caacaggtat cggattaacg
      181 agatatagag aatcaaaatg gttaaacgat aaagagttga aaaataatta tgaaatggct
      241 aaacaaacgg tattaaataa tggttatttg aattcggatt gcctttgtca cgggaaaatg
      301 ggcaacatgg aattatttat gaatttagat gactccttga aaaatgaagt agatatagaa
      361 ggtatcatac ttaatattgt tcgtaattct caaaaatttg gttgggaatc tggcttgcca
      421 caacacacaa gagtgtttaa tatgatggtt ggtgaaatag ggatagcata ccagttactt
      481 agatatatat ccaattatga agtaccatca ttattgttat tagatgttcc aaaagggagt
      541 attgaaaatg aaaaagatta caccgattga acaaacaact cctactgaat gtggattatg
      601 ttgtttatat atgatgttag attattttga tatttcagaa acatatttta aattgaaaca
      661 acaagtcaat ttagggagaa atggactgag tataaagaat atctcagata ttgcttctat
      721 ctacggagtt acttgtaaga cttatcgttt ttccaaatat cccgaaaact tacctgtcat
      781 ggtatttgtt tcagattcgc attttgtaat tttagaggat attcgtgatg atgcctttac
      841 tattgttgac cctgctgttg ggaaatatgt cttagcaaag aatgaatttt ttgaattatc
      901 tcctaaattt tataccgaat ttttttatga taaggcgact aattcttcaa aaaaaatagc
      961 caaacgagga ttagttggca gaaacgtaaa ggaaatgata tttgtaaata ggaaggatac
     1021 ttttttaacc attctatata ctctgatttt tcagattatc acagtgtcaa ttccattttt
     1081 tataagggga attattgatg gaaattgggt tttccttaaa aagtttggct at
//
LOCUS       DAUDWO010000099         1117 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.100, whole genome shotgun sequence.
ACCESSION   DAUDWO010000099 DAUDWO010000000
VERSION     DAUDWO010000099.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1117)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1117)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1117
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.100"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..525
                     /locus_tag="VHC05_001749"
     CDS             <1..525
                     /locus_tag="VHC05_001749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HEQ5403018.1"
                     /translation="SVFEGYFNSLISYTRMLSEDRSVKLILVEELLSELHFEVDDLLN
                     INNIEFSICNRLIITSFYGDEENLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIH
                     FEIWNNGERFSDSTLKKGDKLFYTEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPV
                     RGGASAIISIKKKI"
     gene            682..822
                     /locus_tag="VHC05_001750"
     CDS             682..822
                     /locus_tag="VHC05_001750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic streptin"
                     /protein_id="HEQ5403019.1"
                     /translation="MTNTIKDFDLDLKTNKKDTATPYVGSRYLCTPGSCWKLVCFTTT
                     VK"
BASE COUNT          394 a          146 c          195 g          382 t
ORIGIN      
        1 tctgtttttg aaggctattt caattcttta atatcttata cacgcatgct ttcagaggat
       61 agatcagtga aactaatttt agttgaggag ctattaagtg agttacattt tgaagtcgat
      121 gacttattga atatcaataa tattgaattt tctatttgta atagacttat tatcacttct
      181 ttttatggag atgaggaaaa tctgataaga gctctttcta accttttagt taatgcaata
      241 agatttatgc ccgtattaga taaaaaaatc gaagttatac tgtctgagtc aggagagcaa
      301 attcattttg aaatatggaa taatggtgag cgtttcagtg atagtacact gaaaaaggga
      361 gataaattat tttacacgga agattatagc agaggtaaca aacattatgg aatcggtttg
      421 gcatttgtta aaggcgttgc tatcaaacac ggtgggaatc ttcaattgaa taatccagtt
      481 agaggaggtg ctagcgccat aatctcgata aaaaagaaaa tttaatagat ttgattgaaa
      541 ctggagtatt tcaggcaaaa aatcgtaaat tttggtgatt tttggctaaa atactttttt
      601 tctgaacaaa ttctgaactt ggggtgtcat aataatcatg taaatatatc ggatgcaaaa
      661 acgtaagaga ggaactagaa aatgactaac acaattaaag actttgatct cgatttgaaa
      721 acaaataaaa aagacactgc tacaccttat gttggtagcc gttacctatg tacccctggt
      781 tcttgttgga aattagtttg ctttacaaca actgttaaat aataaagtta tcattatcat
      841 caacattata atttcaaata atttgatata tttataaatt taggggagta gactgatttt
      901 agtttgctcc tttattagta gataaggaag ttatacatga ttaaagctca gctaaagaat
      961 ctaataaaaa caattcatct cgtaaaagag gctggtttct ccctactggt gttctcaatt
     1021 gctattagct tatttcaagg gattttaccc atttttagta tgctactagt tcaaaaaatg
     1081 ttaaacatta taacgactga tataaaaaat tttcaca
//
LOCUS       DAUDWO010000100         1103 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.101, whole genome shotgun sequence.
ACCESSION   DAUDWO010000100 DAUDWO010000000
VERSION     DAUDWO010000100.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1103)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1103)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1103
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.101"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            399..>1103
                     /locus_tag="VHC05_001751"
     CDS             399..>1103
                     /locus_tag="VHC05_001751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="HEQ5403020.1"
                     /translation="MKSYLCSNFLKIKNTSYLLIHILAALLFPLLLFFYWSQRGGLQS
                     RTVLFSYFQIVGVLLPFVASIVCIQLKNLEESSGKYKYLLGYSQSNYKPFIVELVFLW
                     LCYCIVLIISITIFILLLKTIGINVSLRLLILNSLIYIIFAYVTYLINHIISYIFSTG
                     VALGISMVGVIAAAFCETSLGDKVWFLIPWAWLLRISDTLYNQQKMAIVPLIVIFFVS
                     CTVALLHIRIFKSWNQD"
BASE COUNT          332 a          157 c          165 g          449 t
ORIGIN      
        1 gtaattagtt ttgtcctacc tactccaagt cttattagta taggtaggat actattaact
       61 atcttgttaa tttggttgac tacactatgg caaatcccgt ttattttatg gctatcaaga
      121 aaaattaatg tgtattttgc tatgattatt aatattatat ctccactaat tattggtaca
      181 agtttttctc tcttaaataa atggtatttg ttcccttatg attggtcgtt gaagttgctt
      241 gagccaatga caagaatgag aataaatagt ataccttttg gagcggagtt tgttccagac
      301 tactcacaga tttttatatc attgttccta ggaattgctt ttttcatctt actgaccaat
      361 ctatttgcta tctctttcaa aaaacaggtg aaatagtcat gaaatcatat ttatgttcta
      421 attttttaaa aatcaaaaat acttcatatt tactaataca tattttagct gcactattat
      481 ttcccttact tctatttttc tattggagtc aacgtggagg tttacaaagc aggactgtat
      541 tattctccta ctttcaaata gtaggtgtac ttcttccttt tgttgcaagt attgtgtgca
      601 ttcaactaaa aaatttagaa gaatcatctg gaaaatataa atatttattg ggttactcac
      661 agtcgaatta taagccattt attgtagaat tagtatttct atggttatgc tattgtatag
      721 tattaattat ttcaattact atatttattc ttttattgaa aactattggt ataaatgtat
      781 ctctcagact acttattttg aatagtttaa tttatatcat ttttgcctat gtaacctatc
      841 tgatcaatca tattattagc tatatattta gtacaggtgt ggcattaggt atttcaatgg
      901 taggtgttat tgctgcagca ttttgtgaaa cgagccttgg tgataaggta tggtttctta
      961 ttccatgggc atggctttta agaatatcag atactctata taaccaacag aaaatggcaa
     1021 ttgttccact tattgttata ttttttgttt catgcacagt agctttactt catatacgaa
     1081 tatttaaaag ttggaatcaa gac
//
LOCUS       DAUDWO010000101         1097 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.102, whole genome shotgun sequence.
ACCESSION   DAUDWO010000101 DAUDWO010000000
VERSION     DAUDWO010000101.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1097)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.102"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..452
                     /locus_tag="VHC05_001752"
     CDS             <1..452
                     /locus_tag="VHC05_001752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="dehydrogenase"
                     /protein_id="HEQ5403021.1"
                     /translation="IAVISYLGISLEEFKKGIFVNAIYIKDLEKHDYSIEILSCINQT
                     VIKIISNLGSFAIREGKIEGGDAKTVRRVTIDDKTILFDPHPKLERYKSELVTGTNTF
                     QIHDDMMDTYISLLEGNAIPEDCYINNAIEITKLLINLYSECEKIYL"
     gene            462..>1097
                     /locus_tag="VHC05_001753"
     CDS             462..>1097
                     /locus_tag="VHC05_001753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-adenosylmethionine synthetase"
                     /protein_id="HEQ5403022.1"
                     /translation="MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYS
                     LYCLDKFGVIPHHNFDKIIIRGGHSVQDFGGSDFIEPIKIIFLGRASKKCFNSPIPLF
                     KIQKKAATKYLNRILPNLDVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKAN
                     DTATMISYWPLTISEELALMIEGYFYKLDKNELPTPRFTKMGGDIKVMVVRN"
BASE COUNT          408 a          135 c          202 g          352 t
ORIGIN      
        1 tcattgctgt catttcttat ttaggaattt cattagaaga attcaaaaaa ggaatctttg
       61 tgaatgctat ttatataaaa gacttagaga aacacgatta ttcaatagaa atattatctt
      121 gtattaatca aacagtgatt aaaattatta gtaatttggg aagttttgca ataagagagg
      181 gcaagattga aggaggtgat gctaaaacag taagaagagt taccattgat gacaaaacaa
      241 tactatttga tccacatcct aaactcgaga ggtataagag tgaattggtg actgggacaa
      301 atacgtttca aatacacgat gatatgatgg acacgtatat cagtttgtta gaaggaaatg
      361 ctattcctga agattgctat atcaataatg caattgagat aacaaaatta ttaattaact
      421 tatattcaga atgtgaaaaa atttatttat gaggtgtaac tatggattta aaaattacaa
      481 acggctttta tgacccaagt catttatcat acgaagtagt agaacgcaaa ggcttaggtc
      541 accctgatac cttagcagat ggaattgctg agcaaattga aattgattac tcactttatt
      601 gtttggacaa gtttggtgtt attccacatc ataattttga taagattatt atccgagggg
      661 gacattcagt tcaggatttt ggtggaagtg actttattga accaattaaa attatttttc
      721 taggtagggc gagcaaaaaa tgttttaata gtccaattcc actttttaaa attcagaaaa
      781 aggctgcaac taaatattta aatagaattt tacctaattt agatgttgaa aattatgtag
      841 aatttgagac attgacctca gattttacta caaaaactaa ttggttctcg cctgaagcaa
      901 tagaagattt accggagtat ctagatgtac caaaggcaaa tgatacagct acaatgataa
      961 gttattggcc attaacaatt tctgaagaat tagcattaat gattgaaggg tatttttata
     1021 aattagataa gaatgaatta ccaacgccaa gatttactaa aatgggtggt gatattaaag
     1081 taatggtcgt aaggaac
//
LOCUS       DAUDWO010000102         1006 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.103, whole genome shotgun sequence.
ACCESSION   DAUDWO010000102 DAUDWO010000000
VERSION     DAUDWO010000102.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1006)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1006)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.103"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..>1006
                     /locus_tag="VHC05_001754"
     CDS             <1..>1006
                     /locus_tag="VHC05_001754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="UDP-glucose/GDP-mannose dehydrogenase family
                     protein"
                     /protein_id="HEQ5403023.1"
                     /translation="VGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSSLKEAA
                     INKLLCKAKNINATSSEELAYKDATFIILSLPTNLKVNKLDTSIIEISVSNILKINKK
                     ATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNESRNSQ
                     LFLDILTDISVEKDSPSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSK
                     KIIEAMGYDQRIGNSHNNPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRK
                     IHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAKLLKSSGKDVIIFEPLINQK
                     K"
BASE COUNT          371 a          146 c          164 g          325 t
ORIGIN      
        1 tgtaggcatt ggatacgttg gattatcgat agggctccta cttgcaaagg aacacgacgt
       61 tacctttttt gatattgata ataaaaaaat tgatttaata aataaaaggc aatcctctct
      121 taaagaagca gctataaaca aacttttatg taaggcaaaa aatattaatg caacttcttc
      181 tgaagaatta gcatataagg atgcgacttt cataatcttg tctttgccaa ccaacctaaa
      241 agttaataag cttgatactt ccattatcga aatttctgta agtaatattt taaagataaa
      301 caaaaaggct acaattgtaa taaagtcgac agttccaatt ggttttacag aatatttaag
      361 gaatcgattt cactacaacg atatcatttt ttcacctgag ttccttaggg aaggatcaac
      421 tattcatgat caattgtatc cttcgagaac tatagttgga aatgaatcta gaaattctca
      481 attattctta gacatactaa cagatatatc ggttgaaaaa gactcgccat ctttattagt
      541 tggctcttct gaagcagaag cgataaagtt attttcgaat gcatacttag cacaaaaaat
      601 tgcttttttt aatgagttgg atacgtttgc tgaaatgcaa aatttggact caaaaaaaat
      661 tattgaggct atgggatatg accagagaat aggaaattcg cacaataatc cttctttcgg
      721 ttttggtggg tactgtcttc ctaaggatat taagcaatta gagtatcatt ttaaagaaat
      781 tccagcacca attattacca gtataagtga gtctaattta ttaagaaaaa ttcatatagc
      841 aaaaatgatt ttgaacagct cagctaaaac aataggaatt tatagaatta attccaaaaa
      901 agattcggat aattgtaggg aatcttctac aattgatgtt gctaaacttt taaaaagcag
      961 tggtaaggat gttatcatct ttgagccatt aattaatcaa aaaaag
//
LOCUS       DAUDWO010000103         1004 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.104, whole genome shotgun sequence.
ACCESSION   DAUDWO010000103 DAUDWO010000000
VERSION     DAUDWO010000103.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1004)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1004)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.104"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..381
                     /locus_tag="VHC05_001755"
     CDS             <1..381
                     /locus_tag="VHC05_001755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine protein kinase"
                     /protein_id="HEQ5403024.1"
                     /translation="WDDKISIFPKELGIRTCNFSTEISKIYYIKTDKKEKQIYHSIWS
                     DSLASLYLNELLGRHISGQVACFQSDNGKYFSTMPLINYEKNNRVREQIVKGIFAKQK
                     LFKITAATPAKIAEAIIENVKKNS"
     gene            436..>1004
                     /locus_tag="VHC05_001756"
     CDS             436..>1004
                     /locus_tag="VHC05_001756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HEQ5403025.1"
                     /translation="MFVIGIPTLNEADNISRLVKQIDEYAVNLGKEIIIINSDSKSTD
                     GTPQIFLETKTYNTKVSIVSEAKGKGYNVRNIFEYAINHVPNFSGLILIDGDVVSMKK
                     MWLEKMFIAIESGNDLIIPNYARKSFEGNATNHFIYPMLVKFFKRDMPYQCISGDFGF
                     SRGLIKDLTLKCNWHKYTLGYGIDIFLTLT"
BASE COUNT          378 a          112 c          189 g          325 t
ORIGIN      
        1 tgggatgata aaatttcaat tttcccaaag gagttgggaa tacgaacttg taatttttct
       61 actgaaatct caaaaattta ttatataaag acagacaaga aagaaaagca aatttatcat
      121 tcaatttgga gtgatagttt agcaagttta tatctaaatg agctattggg aaggcatatt
      181 tctggacagg ttgcatgttt tcaatcagat aatggaaaat atttttctac aatgcctttg
      241 ataaattatg aaaaaaataa tcgggtacga gaacagatag tgaagggtat tttcgctaaa
      301 caaaaattat ttaaaattac agcagctacg ccagctaaga ttgcagaagc gattatagaa
      361 aatgttaaga aaaactcata gtgtgtgtga atttggggat taatatgaag tattgaaaaa
      421 ggagtaagag taattatgtt tgtgataggc attccaactt taaatgaggc agataatatc
      481 agtagattag ttaaacaaat tgatgagtat gctgtaaatt tagggaaaga aattattatt
      541 attaattcgg atagtaaaag tacagatgga actccgcaga tttttttaga aaccaaaact
      601 tataacacca aagtttcgat agtatcagaa gctaaaggaa aaggttataa tgtgagaaat
      661 attttcgaat atgcaataaa tcatgtgccg aatttctccg gtttaatttt gattgatgga
      721 gacgttgtct caatgaaaaa aatgtggtta gaaaagatgt ttatagcaat tgaatctgga
      781 aatgatctta taatcccaaa ttatgctaga aaatcttttg aaggaaatgc gacaaaccat
      841 tttatttatc ccatgttagt gaaatttttc aaacgtgata tgccttatca atgcatctct
      901 ggtgattttg gattttcaag aggattgata aaagatttaa ctttgaagtg taactggcac
      961 aaatatacat taggttacgg gatagatatt tttttaacct taac
//
LOCUS       DAUDWO010000104         1002 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.105, whole genome shotgun sequence.
ACCESSION   DAUDWO010000104 DAUDWO010000000
VERSION     DAUDWO010000104.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1002)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1002)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1002
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.105"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..934
                     /locus_tag="VHC05_001757"
     CDS             <1..934
                     /locus_tag="VHC05_001757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HEQ5403026.1"
                     /translation="SKIVYQKKFFHLAKKSEKVISTYHVTDDLKPFQVKDLVSGHLER
                     IQEEVEKKYPDAGFNSDKYNGLKESNFLLSDGFEVKSGNLIFDKKLTIPLTTLFDVIN
                     PDFLANSDRAAYDNYRTYKEQHPKKLVALTFDDGPDPTTTPQVLDILAKYQAKGTFFM
                     IGSKVVNNENLTKRVSDAGHEIANHTWDHPNLTNLSVSEIQHQVNMTNQAIEKACGKK
                     PRYLRPPYGATNATVQQSSGLTQMLWTVDTRDWENHSTDGIMTNVKNQLQPGGVVLMH
                     DIHQTTINALPTVMEYLKAEGYECVTVSELYAHQ"
BASE COUNT          360 a          161 c          185 g          296 t
ORIGIN      
        1 ttctaaaata gtttatcaga aaaaattttt tcatttggct aaaaaatcag aaaaagttat
       61 aagtacatat cacgttacag acgacttgaa accgtttcag gtaaaggatc tagtatcagg
      121 acatttagaa agaatacaag aagaagttga aaaaaaatat ccagatgctg gttttaatag
      181 cgataagtat aatggcttaa aagaatctaa ttttttatta agcgatggct ttgaggtaaa
      241 atcgggaaac cttatttttg ataaaaagct aacgatacct ttgacgacat tatttgatgt
      301 tattaatcca gattttttag caaatagcga tagagctgcg tatgataatt ataggaccta
      361 caaagaacag catcccaaaa aactagttgc attaacgttt gatgatggtc cagatccgac
      421 gacgactcct caagttttag atattttggc aaaataccag gctaagggaa ctttctttat
      481 gataggttca aaagttgtga ataatgaaaa tcttactaaa cgtgttagcg acgctggcca
      541 tgaaattgct aatcatactt gggatcatcc caatctgact aatctttcag tcagcgagat
      601 tcaacatcaa gttaatatga cgaaccaggc tattgaaaaa gcttgtggca agaaacctcg
      661 ctatttacgc cctccatacg gagctacaaa tgcaactgtt cagcaatcat caggattaac
      721 acaaatgctt tggacggttg atacaagaga ttgggaaaat catagcactg atggcattat
      781 gactaatgtc aaaaaccaat tgcaaccggg aggagttgtt ttaatgcatg atattcatca
      841 aacaactatc aatgctttgc cgacagttat ggaatatcta aaagcagaag gatacgaatg
      901 tgtgactgta tcagaactct atgcgcatca gtaagtaata tcgttatgtt tctttagaat
      961 tgatatacta aacaatccaa ttacttttga agtaattgga tt
//
LOCUS       DAUDWO010000105          966 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.106, whole genome shotgun sequence.
ACCESSION   DAUDWO010000105 DAUDWO010000000
VERSION     DAUDWO010000105.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 966)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 966)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.106"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(68..826)
                     /gene="mf2"
                     /locus_tag="VHC05_001758"
     CDS             complement(68..826)
                     /gene="mf2"
                     /locus_tag="VHC05_001758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNase Mf2"
                     /protein_id="HEQ5403027.1"
                     /translation="MKLSKQKASLLTAVLLLLSLSITTITVDAARVRTYPNVSHANTH
                     YKNTVSSKLLPFTANYQLQLGELDNLNRATFSHIQLQDRHETKDVRTKINYDPVGWHN
                     YQFPYGDGSKSSWVMNRGHLVGYQFCGLNDEPRNLVAMTAWLNTGAYSGANDSNPEGM
                     LYYENRLDSWLALHPDFWLDYKVTPIYSGNEVVPRQIELQYVGIDSSGELLTIRLNSN
                     KESIDENGVTTVILENSAPNINLDYLNGTATPKN"
BASE COUNT          310 a          158 c          160 g          338 t
ORIGIN      
        1 aaatagcagt aagtagttaa aaatcagatt tctgtttatt tagaaatttt ataaatgtat
       61 ttatatttta gtttttagga gtggcagttc catttaaata gtcaaggttg atatttggag
      121 cagagttttc taagattact gtagtaacac cattttcatc aatactttct ttattactat
      181 ttagccttat agtaagcaac tcaccagatg aatcaattcc aacatactgt aattcaattt
      241 gtcgaggcac tacttcattg ccactatata taggagtgac tttataatct agccaaaagt
      301 cagggtgaag tgcaagccaa gaatctaaac ggttttcata gtataacatc ccttcaggat
      361 tgctgtcatt tgctcctgaa taagcacctg tgtttagcca ggctgtcatt gccactaaat
      421 ttcttggttc atcgtttaat ccacaaaatt gatatccgac tagatgccca cgattcatta
      481 cccatgaaga ttttgagcca tctccgtatg gaaattgata gttgtgccat cccacagggt
      541 cataatttat tttagtgcgt acatctttag tttcgtgtct atcttgcagt tggatatgtg
      601 aaaaggtagc gcggttaagg ttatccaact caccaagttg taactgataa ttagcagtaa
      661 aaggtaagag cttactagaa acagtatttt tataatgtgt gtttgcatgg gatacattcg
      721 gataagttcg taccctagct gcgtcaacag ttattgtcgt tatagaaaga gaaagtaaca
      781 gtaaaacagc ggtaagcaaa cttgcctttt gtttagataa tttcatgata acacctaaac
      841 ctttccattt ttagctttta gagtggatca aatattgcac ttttctagtt aattatatca
      901 ctttaaatta aaaaaactta aaattaataa aattaattta tcaataatat tacgctaaaa
      961 tttctt
//
LOCUS       DAUDWO010000106          900 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.107, whole genome shotgun sequence.
ACCESSION   DAUDWO010000106 DAUDWO010000000
VERSION     DAUDWO010000106.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 900)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 900)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.107"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(19..92)
                     /locus_tag="VHC05_001759"
     tRNA            complement(19..92)
                     /locus_tag="VHC05_001759"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(56..58),aa:Ile,seq:cat)
     gene            complement(113..186)
                     /locus_tag="VHC05_001760"
     tRNA            complement(113..186)
                     /locus_tag="VHC05_001760"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(150..152),aa:Met,seq:cat)
     gene            complement(192..265)
                     /locus_tag="VHC05_001761"
     tRNA            complement(192..265)
                     /locus_tag="VHC05_001761"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(229..231),aa:Pro,seq:tgg)
     gene            complement(272..345)
                     /locus_tag="VHC05_001762"
     tRNA            complement(272..345)
                     /locus_tag="VHC05_001762"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(309..311),aa:Arg,seq:acg)
     gene            complement(362..446)
                     /locus_tag="VHC05_001763"
     tRNA            complement(362..446)
                     /locus_tag="VHC05_001763"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(410..412),aa:Leu,seq:taa)
     gene            complement(455..526)
                     /locus_tag="VHC05_001764"
     tRNA            complement(455..526)
                     /locus_tag="VHC05_001764"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(492..494),aa:Gly,seq:gcc)
     gene            complement(539..611)
                     /locus_tag="VHC05_001765"
     tRNA            complement(539..611)
                     /locus_tag="VHC05_001765"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(576..578),aa:Thr,seq:tgt)
     gene            complement(622..703)
                     /locus_tag="VHC05_001766"
     tRNA            complement(622..703)
                     /locus_tag="VHC05_001766"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(667..669),aa:Leu,seq:tag)
     gene            complement(709..781)
                     /locus_tag="VHC05_001767"
     tRNA            complement(709..781)
                     /locus_tag="VHC05_001767"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(746..748),aa:Lys,seq:ttt)
     gene            complement(813..885)
                     /locus_tag="VHC05_001768"
     tRNA            complement(813..885)
                     /locus_tag="VHC05_001768"
                     /product="tRNA-Asp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(850..852),aa:Asp,seq:gtc)
BASE COUNT          241 a          261 c          197 g          201 t
ORIGIN      
        1 taatgattat ctatgatatg gaccttgtag gactcgaacc tacgaccgct cggttatgag
       61 ccgagtgctc taaccagttg agctaaaggt cccaagtcat ccataaaaat aatagcggcg
      121 aaggggatcg aacccccgac ctcccgggta tgaaccggac gctctagcca gctgagctac
      181 accgccatta atcgggaaga caggattcga acctgcgaca ccttggtccc aaaccaagta
      241 ctctaccaag ctgagctact tcccgaactg atgcacccta gaggagtcga acctctaacc
      301 gcctgattcg tagtcaggta ctctatccag ttgagctaag ggtgctattt caaaaaatta
      361 atgccgagga ccggaatcga accggtacga tgtaaaccat cgcaggattt taagtcctgt
      421 gcgtctgcca gttccgccac cccggctcct caaaagcgaa cgacgggatt cgaacccgcg
      481 acccccacct tggcaaggtg atgttctacc actgaactac gttcgcaact aatctcaatg
      541 ccggctacat gacttgaaca cgcgaccctc tgattacaaa tcagatgctc taccaactga
      601 gctaagccgg ctaatctttt atgcgggtta agggacttga acccccacgc cgttaagcgc
      661 cagatcctaa atctggtgcg tctgccaatt ccgccaaacc cgcttttatg acccgtactg
      721 ggctcgaacc agtgacccat tgattaaaag tcaattgctc taccaactga gctaacgagt
      781 ctttccttca aaaaatatga ctactctttg aacggtcccg acgggaatcg aacccgcgat
      841 cttcgccgtg acagggcgac gtgataaccg ctacactacg ggacctgtat tttccaatac
//
LOCUS       DAUDWO010000107          887 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.108, whole genome shotgun sequence.
ACCESSION   DAUDWO010000107 DAUDWO010000000
VERSION     DAUDWO010000107.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 887)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 887)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.108"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(<1..853)
                     /locus_tag="VHC05_001769"
     CDS             complement(<1..853)
                     /locus_tag="VHC05_001769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEQ5403028.1"
                     /translation="MTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYF
                     DTENNIIKALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLG
                     SIETTSLMNFYGQEEKYHTITVRVHIKNYPAVAYMMAVVNVEQLDRANERYERIIIIV
                     MSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNRLESLFRK
                     PNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENY
                     ELVAKEYG"
BASE COUNT          312 a          168 c          127 g          280 t
ORIGIN      
        1 ttccatattc tttagcaact agttcataat tctcaaaaat agcattaaaa aaatctgtat
       61 ctaaatgagt ccactgtgga ttaatgccat catctcgtct tgctaaattt aataaattag
      121 ttgttaagat gcgcatgttg cgaacctcgt ctaaactaga agcgagatgc tcactatttt
      181 ctaatatcgt ttcgttgggc ttacgaaaaa gcgattccag acgattctgt aagaccgcca
      241 aaggggtcct taattcatga ctagcatttt caacaaacat tttttgtttt tcatagcttt
      301 ctaaaatagg ttttctgctc cacttggcta aataaatact tgctaaaata gaaattagcc
      361 aaaaaacact cataactata ataataatgc gctcataacg ttcattagcg cggtctaatt
      421 gttccacatt tactactgcc atcatatagg caactgcagg ataatttttg atatgaaccc
      481 ttacagttat cgtatggtat ttttcttctt gtccataaaa attcattaaa ctggtggttt
      541 caatactccc caaccggcgt ttatctaaat gaaaattttg atagttagaa aacgcatcaa
      601 aagcatttaa aattgttcca ttagcactaa acaaaatgat atctgtatta gctgcaggcg
      661 ttcctaataa cttagaacta tctgaatcag gcagcgcctt aataatgtta ttttcagtat
      721 caaagtaaaa agaagatatt ctagccatcg tacgattagc atagctactt gcattattac
      781 taacagaaac taaactactg tcaactgacg aataaacgcc aaaccgcata atctgtaaga
      841 taataatagt cataatgaca aaaatacctg taaaaaccgc aaaaaaa
//
LOCUS       DAUDWO010000108          718 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.109, whole genome shotgun sequence.
ACCESSION   DAUDWO010000108 DAUDWO010000000
VERSION     DAUDWO010000108.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 718)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 718)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.109"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(3..533)
                     /locus_tag="VHC05_001770"
     CDS             complement(3..533)
                     /locus_tag="VHC05_001770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEQ5403029.1"
                     /translation="MEIRNRDPHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEEL
                     FSHRIEKAITYVQDNQGKTLAEDSFVFINVKSQIQVPFSDLLYIETSLIPHKLILYST
                     KQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLK
                     IRSLIKVVEELHTKEK"
BASE COUNT          229 a          135 c          105 g          249 t
ORIGIN      
        1 aactatttct ccttagtgtg caactcttct actactttta ttaatgatcg tattttcaat
       61 ctcgaaacaa tacaagataa tcctcccttt aaataaacta accgttcgga tctatctatt
      121 gatgatatat tatagggatt aacaacaaag gaacgatgac attgaaataa tcgatcatct
      181 tgctcaacaa tttctgataa ttggccataa aattctactc tttgtttagt agaatagaga
      241 atgagtttat ggggaattag tgaggtttca atatacagca aatctgaaaa ggggacttgt
      301 atctgggact ttacattaat aaaaacaaat gaatcctccg ctaacgtttt tccttggtta
      361 tcttgtacat aagttatagc tttttcaatg cgatgactaa ataactcctc tggcaactct
      421 ttgtcaataa agtctaaagc tgaaacctgg tattgaaaag ataccggcat aaattctgaa
      481 tgtgtggtca caaaaactat cactgcgtgc ggatctctat ttctaatctc cacagcaatt
      541 tccattcctt ttttatcttc tcccttaatg tcaatgtcaa gaaaaaaagc tgatgtcttc
      601 ctctctctga tatatcttca agcagctgat tgggtttacc ataaacttcc aagtggttaa
      661 cctccaactt attatcagtc aaaatcttat aaataatttt tccaattctg gtttgatg
//
LOCUS       DAUDWO010000109          523 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.110, whole genome shotgun sequence.
ACCESSION   DAUDWO010000109 DAUDWO010000000
VERSION     DAUDWO010000109.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 523)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.110"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(82..165)
                     /locus_tag="VHC05_001771"
     tRNA            complement(82..165)
                     /locus_tag="VHC05_001771"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(129..131),aa:Leu,seq:caa)
     gene            complement(185..256)
                     /locus_tag="VHC05_001772"
     tRNA            complement(185..256)
                     /locus_tag="VHC05_001772"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(222..224),aa:Gln,seq:ttg)
     gene            complement(265..337)
                     /locus_tag="VHC05_001773"
     tRNA            complement(265..337)
                     /locus_tag="VHC05_001773"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(302..304),aa:His,seq:gtg)
     gene            complement(349..419)
                     /locus_tag="VHC05_001774"
     tRNA            complement(349..419)
                     /locus_tag="VHC05_001774"
                     /product="tRNA-Trp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(385..387),aa:Trp,seq:cca)
     gene            complement(426..506)
                     /locus_tag="VHC05_001775"
     tRNA            complement(426..506)
                     /locus_tag="VHC05_001775"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(470..472),aa:Tyr,seq:gta)
BASE COUNT          151 a          130 c          115 g          127 t
ORIGIN      
        1 gtaatataag agattgtact acgtagctac agcctaagat caaaacaaaa aacaaggttt
       61 acaaaccttg tttttcaagt ataccggcgg ccggggtcga accggcacgt ccttgcggac
      121 actggatttt gagtccagcg cgtctgccaa ttccgccacg ccggctttaa atataaaatt
      181 taaactgggg tagctggatt cgaaccaacg catgagggag tcaaagtccc ttgccttacc
      241 gcttggctat accccaataa aataggcgag tgatgggaat cgaacccacg aatgtcagag
      301 ccacaatctg atgtgttaac cacttcacca cacccgccat atttctaaca cgggcagtag
      361 gaatcgaacc cacactgaag gttttggaga ccttagttct acctttaaac tatgcccgtt
      421 taggatggaa agagagggat tcgaaccccc gaacccgaag gagcggattt acagtccgcc
      481 gcgtttagcc tcttcgctat ctttccgtaa aatattaaat ttt
//
LOCUS       DAUDWO010000110          489 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.111, whole genome shotgun sequence.
ACCESSION   DAUDWO010000110 DAUDWO010000000
VERSION     DAUDWO010000110.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 489)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.111"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..>489
                     /locus_tag="VHC05_001776"
     CDS             <1..>489
                     /locus_tag="VHC05_001776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="serine/threonine protein kinase"
                     /protein_id="HEQ5403030.1"
                     /translation="GLVEISFDVPDFIFQKIKEQNNKIRYYSKSINILGSVKFINSNQ
                     QFIEYDGNGNILVYGRLKYFKEGISLYYIGEYLAECLLIEYSDTLLIHAAAVYNPLSG
                     HSILLLGDKGAGKTTVAMRLCIEHGYHLIGNDQVIFGSNSGILLTYAGTSFFKIRRTA
                     VLS"
BASE COUNT          172 a           58 c           90 g          169 t
ORIGIN      
        1 tgggttggtt gaaatttctt ttgatgtgcc tgactttata tttcaaaaaa taaaagagca
       61 gaataataaa attagatatt atagcaaatc aataaatata ttaggtagtg taaaatttat
      121 taacagcaat cagcaattta tagaatatga tggcaatgga aatattttag tttatggaag
      181 attaaagtat tttaaagaag gaatttcatt atactacatt ggagagtact tagctgaatg
      241 tctcttgatt gaatatagtg acaccttatt aattcatgca gcagcagttt ataatccttt
      301 atctggccat tcaattttac tattaggaga taaaggtgct ggaaaaacta cggttgcaat
      361 gaggctttgt atagaacatg ggtatcacct tattggtaat gaccaagtaa tatttggttc
      421 gaactctgga atactactaa cttatgcagg gacatctttc tttaaaataa gaaggacagc
      481 tgttttgtc
//
LOCUS       DAUDWO010000111          441 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.112, whole genome shotgun sequence.
ACCESSION   DAUDWO010000111 DAUDWO010000000
VERSION     DAUDWO010000111.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 441)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.112"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
BASE COUNT          166 a           69 c           58 g          148 t
ORIGIN      
        1 aacaatatcg ccaaatcgat tgaatacaaa gaattattat taagtacatt cttattaatt
       61 ggtaagccac agttagagct aaatcttgga aaaagtaaat tcatattccc ctctttgttt
      121 ccatttcatg tgcttcgcaa ttcaatacca gaaaaaaact taagtgatat gacaaccagg
      181 catacctctt caactggtaa aataacgacg tacataaagg tagagaataa attttccgaa
      241 aacggataca catgtgattt agatttttta tattatcaag acataattga aaatttacaa
      301 tacgatgatt ttataaaaga tattttttat ctgtatgtaa acaagcctgc aaatcttgaa
      361 cctataacag cacacattat tgacttcata tatttgtttt tcagtaaagt tggtatttgc
      421 gacatttcaa atacgaattt a
//
LOCUS       DAUDWO010000112          424 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.113, whole genome shotgun sequence.
ACCESSION   DAUDWO010000112 DAUDWO010000000
VERSION     DAUDWO010000112.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 424)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 424)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.113"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            <1..>424
                     /locus_tag="VHC05_001777"
     CDS             <1..>424
                     /locus_tag="VHC05_001777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="S-adenosylmethionine synthetase"
                     /protein_id="HEQ5403031.1"
                     /translation="EKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNK
                     THGIISSFRPNTMEAPAGKNCTYFVGKVWGFLSDTIAKEIYEAFNTPCQIIMQLNIGS
                     KLYRPTHLFIQTEESVDQERVLEIVNRHLNNGKQNTNLI"
BASE COUNT          165 a           52 c           71 g          136 t
ORIGIN      
        1 agaaaaaatt aagaaatata ttgaacaaaa gtataaaaac ataagctttt ctattgatta
       61 ccattattat ttaactacta caggttcttg tattgatttc ggagaagaag gtgcagttgg
      121 tcgaggtaat aaaactcatg gtatcatatc aagttttagg ccaaatacta tggaagcacc
      181 agctggaaaa aattgtactt attttgtagg aaaggtttgg ggatttttgt ctgatactat
      241 tgccaaagaa atttatgaag cattcaatac tccctgtcaa atcattatgc aattaaatat
      301 tggatcaaaa ttgtatagac caacccattt atttattcag acagaagaaa gtgttgatca
      361 agaaagagta ttagaaattg ttaacaggca tttaaataat ggtaaacaaa atactaattt
      421 aatc
//
LOCUS       DAUDWO010000113          385 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.115, whole genome shotgun sequence.
ACCESSION   DAUDWO010000113 DAUDWO010000000
VERSION     DAUDWO010000113.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 385)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 385)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.115"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
BASE COUNT          130 a           42 c           78 g          135 t
ORIGIN      
        1 gatggattac tttaattgac tttagtgtgt tagatgccag tttggatttt tgatatttgt
       61 gttgagttta aaagataaaa acacttgatg aaaatctgtt ttttcttaga aaggggacca
      121 gtatgattga gacgctaatg agtacgttgg aaatggttag aaaaaaaatc ctagtaggac
      181 tgcaatcgaa gatgactttg aggaatataa aaagagaaat ctaccaatct ttgtcagtga
      241 agatgatagt atgatctatt atagaccagg gttcattttt aatgaattct atcccaatat
      301 ttcaggttgg agacaagaac taaagactaa gcttactagt atttctttaa tttctttaaa
      361 ttttattggt gttgttgacg aacaa
//
LOCUS       DAUDWO010000114          377 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.116, whole genome shotgun sequence.
ACCESSION   DAUDWO010000114 DAUDWO010000000
VERSION     DAUDWO010000114.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 377)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 377)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.116"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            118..>377
                     /locus_tag="VHC05_001778"
     CDS             118..>377
                     /locus_tag="VHC05_001778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HEQ5403032.1"
                     /translation="MRLDKYLKVSRLIKRRSVAKEVADKGRIKVNGILAKSSTNVKLN
                     DHIEISFGNKLLTVRVIEIKDSTKKEDALKMYEIISETRITL"
BASE COUNT          161 a           42 c           69 g          105 t
ORIGIN      
        1 aacgaactag ctctttatac ttttgtcaaa aatctaagat ctttgctgcg aaattaggat
       61 cttttctacc atttaaaaaa taaaaatgat aaaatgaaga ggattgtagg agaaattatg
      121 agactagata aatatctaaa ggtatcgcgc cttattaaac gtcgttcagt agcaaaagaa
      181 gttgcggata agggacgaat taaagttaat gggatacttg ctaaaagttc aacgaatgta
      241 aaactaaatg atcacattga aattagtttt ggaaataaat tactgacagt aagagtcatt
      301 gaaataaaag atagtacaaa aaaagaagat gctcttaaga tgtatgagat aatcagtgaa
      361 acaaggataa cattaaa
//
LOCUS       DAUDWO010000115          351 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.117, whole genome shotgun sequence.
ACCESSION   DAUDWO010000115 DAUDWO010000000
VERSION     DAUDWO010000115.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 351)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 351)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.117"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(97..>351)
                     /locus_tag="VHC05_001779"
     CDS             complement(97..>351)
                     /locus_tag="VHC05_001779"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5403033.1"
                     /translation="ALASGLIFSSSQAYAAEIQQETFKTKIEAIYQALLTIENAPFNQ
                     YYTIKEIPGSDGQPSKFVYEVSILEKVGSIGPKDSSEINE"
BASE COUNT          121 a           52 c           56 g          122 t
ORIGIN      
        1 tatagaaaat aggagtagat tttgcaaatg ctagaagcat ttctataaaa aatcatgcaa
       61 aatatagatt tgcatgattt taaaaatttc aaaagtttat tcattaattt cagaactatc
      121 ctttggaccg atacttccaa ctttctctaa aatgctaact tcataaacaa acttagaagg
      181 ctggccatca gatcctggaa tttcctttat tgtgtagtat tggttaaaag gagcattctc
      241 tatagttagt aaagcttgat aaatagcttc tatttttgtc ttgaaagttt cttgttgtat
      301 ttcagctgca taagcttgag aactgctaaa gataagacct gaagctaaag c
//
LOCUS       DAUDWO010000116          345 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.119, whole genome shotgun sequence.
ACCESSION   DAUDWO010000116 DAUDWO010000000
VERSION     DAUDWO010000116.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 345)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 345)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.119"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
BASE COUNT          123 a           59 c           37 g          126 t
ORIGIN      
        1 taaatttact tacatactgt atttattatt tagataagct aaacatattg aaatatattc
       61 caccaatcac acttcttctc aagattaata aaaattgaaa acttagttgt actttagata
      121 attgtatact ctcaataaat aaagtggtaa taaatataac gaatgttcct cactactata
      181 tctataaata ttgttaattg tattagacaa aattccgtcc cattctacct ctgacagccc
      241 atgtggatac tgtttttctt cctgtaataa aaacaacgct cttaacttta aattctcgat
      301 atcattgctg gataggatat cactggactt aataaactgt cttga
//
LOCUS       DAUDWO010000117          343 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.120, whole genome shotgun sequence.
ACCESSION   DAUDWO010000117 DAUDWO010000000
VERSION     DAUDWO010000117.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 343)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.120"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
BASE COUNT          140 a           46 c           49 g          108 t
ORIGIN      
        1 aaaatagaat tttttctaac taaaaataat agcacaatct ttggcagcaa tctgaattgt
       61 ttttccataa aagatttaag cacttacgtt tgcttaaaat ataggttatg tgacgtgcgt
      121 gcaagatcag attataacaa aatagttcca aataagccta tcactgagaa agcatcacag
      181 aagagttaaa cttttttgta ttagcgtttt atcagtacaa cctaacactt atttttataa
      241 aaaaataaaa aagctattga caatcttata caagatatcg tatactaata aagctgttgt
      301 aaatatggta aagcaataga tgctatcagg aaaaaaatgt gaa
//
LOCUS       DAUDWO010000118          332 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.denovo.121, whole genome shotgun sequence.
ACCESSION   DAUDWO010000118 DAUDWO010000000
VERSION     DAUDWO010000118.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 332)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.denovo.121"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            complement(<1..326)
                     /locus_tag="VHC05_001780"
     CDS             complement(<1..326)
                     /locus_tag="VHC05_001780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017647425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5403034.1"
                     /translation="MINLIKNRLAELLAQRQLKITKVAKDTGISRNTITATAQNDGTM
                     IKLETIDILCNYLGVTPAEFFEFIPVLFDLEVMTTLFEVDYHKNGVYEFAGFDSILYK
                     SDIFLDL"
BASE COUNT          113 a           56 c           47 g          116 t
ORIGIN      
        1 agatctaaaa aaatatcaga tttgtaaagt atagaatcaa aaccagcgaa ttcgtaaacg
       61 ccgtttttat gataatcaac ttcaaacaaa gttgtcatta cttctagatc gaataacacc
      121 ggaatgaatt caaagaattc agcaggagtg actcctaaat agttacataa aatatctatg
      181 gtttcaagtt ttatcattgt cccatcattt tgggcagtcg ctgttatagt attcctagaa
      241 atacctgtat cttttgcaac tttagtaatt tttaattgtc tttgtgccaa caattcagct
      301 aagcgatttt ttatcaaatt aatcatgcct tt
//
LOCUS       DAUDWO010000119        16920 bp    DNA     linear   BCT 01-JAN-2024
DEFINITION  TPA_asm: Streptococcus pyogenes strain MGAS31773
            SAMN14440685-rid18344913.guided.040, whole genome shotgun sequence.
ACCESSION   DAUDWO010000119 DAUDWO010000000
VERSION     DAUDWO010000119.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN14440685
            Sequence Read Archive: SRR11403690
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 16920)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16920)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 09-JUN-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001731856.2
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001731856.2
            Genome Coverage       :: 204x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/09/2023 18:42:44
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,761
            Genes (coding)                    :: 1,693
            CDSs (with protein)               :: 1,693
            Genes (RNA)                       :: 37
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1 (16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 37 of 68
            Pseudo Genes (incomplete)         :: 30 of 68
            Pseudo Genes (internal stop)      :: 17 of 68
            Pseudo Genes (multiple problems)  :: 15 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16920
                     /organism="Streptococcus pyogenes"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN14440685-rid18344913.guided.040"
                     /strain="MGAS31773"
                     /serotype="emm4"
                     /isolation_source="patient clinical specimen"
                     /host="Homo sapiens"
                     /db_xref="taxon:1314"
                     /country="Iceland: Reykjavik"
                     /collection_date="2000-02"
                     /collected_by="Department of Clinical Microbiology,
                     Lanspitali University Hospital"
                     /note="genotype: emm4"
     gene            14..2015
                     /locus_tag="VHC05_001781"
                     /pseudo
     CDS             14..2015
                     /locus_tag="VHC05_001781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612436.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="potassium transporter Kup"
     gene            complement(2039..2317)
                     /locus_tag="VHC05_001782"
     CDS             complement(2039..2317)
                     /locus_tag="VHC05_001782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HEQ5403035.1"
                     /translation="MTTKKAYMYVLECVDKTLYTGYTTDLKKRLATHNAGKGAKYTRY
                     RLPVSLLYYEVFDSKEAAMSAEALFKKRKTRSQKLAYIATHQKEKKNH"
     gene            complement(2307..3161)
                     /locus_tag="VHC05_001783"
     CDS             complement(2307..3161)
                     /locus_tag="VHC05_001783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HEQ5403036.1"
                     /translation="MKADFSKVKITLQTFTSSLFYVKITGMIKAILKEGERIDQLFSS
                     DVGIIQNKDVFSYSIDSVLLSRFPKMPSKGLIVDLCSGNGAVGLFASTRTKAAIVEVE
                     LQERLADMGQRSIQLNQLEDQVTMICDDLKNLLNHVPRSGVDLMLCNPPYFKSHESSK
                     KNVSEHYLLARHEVTTNLEEICQVARHALKSNGRLAMVHRPDRFLEIIDSLRANGLAP
                     KRVQFVYPKLGKSANMLLIEAIKDGSIEGMTILPPLVVHKENGEYTDHIFEIYFGAAS
                     KGKPNHDH"
     gene            3201..3941
                     /locus_tag="VHC05_001784"
     CDS             3201..3941
                     /locus_tag="VHC05_001784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HEQ5403037.1"
                     /translation="MFYAYLRGLVVFLLWVVNGNAHYHHEEKMLDASENYILVAPHRT
                     FWDPVYMAFAARPKQFIFMAKKELFANRLFAWWIKMCGAFPIDRDKPSPDAIRYPVNM
                     LKKSNRSLLMFPSGSRHSQEVKGGVAVIAKLAKVKIMPAAYQGPMSVKRLLAGERVDM
                     TFGNPIDVSDIKRMNDEGIAEVANRIQAEFDRMDDELAPFQPGKARNPLTYLYRLPLG
                     LVLVVVLLLTMLFSYIASFVWNPDKHRH"
     gene            4141..4803
                     /locus_tag="VHC05_001785"
     CDS             4141..4803
                     /locus_tag="VHC05_001785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEA family DNA-binding protein"
                     /protein_id="HEQ5403038.1"
                     /translation="MLDELLIKGKSFLRERYFLPYLISLLLGLFLILSFSFLFWGNRQ
                     SKAAVPALREISPVKQQVSEEKKEIQEDNSILVDLKGAVQKEGVYKLTASSRVRDVIE
                     LAGGLTSEADKHAINFAEKLTDEQVVYVPKQGEEISVLPRSLVSGKKETASKDQSKVH
                     INKASLEELQHIPGIGAKRAQDIIDMRDKLGGFKALEDLRQVSGIGEKTLEKLKDDIF
                     LD"
     gene            4784..6469
                     /locus_tag="VHC05_001786"
     CDS             4784..6469
                     /locus_tag="VHC05_001786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003057995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEC/Rec2 family competence protein"
                     /protein_id="HEQ5403039.1"
                     /translation="MTFSWTKLVPLSKIQFAFLILVLFYQIHSPSWLTFLLSLSLICL
                     LVKRLSKKEFLGVFAILSFCALFLLYQKQQLVQKLEIQPVQITSVALVPDSIRINGDQ
                     LAVLGRHGKHSYQLFYRLKSQAEAQLFKKEHRWLVMHAKVTLEKAEEVRNFKGFNYQT
                     FLAYQGIYRIGKVEQIEQLEVISPESICDYLSSLRRRAIVHCQQHFPRPMSHYLTGLL
                     FGYLDTSFGEMTDYYSQLGIIHLFALSGMQVGFFLTCFRRVLLLLAVPLEWIKWIELP
                     FACFYAALTGYSISVIRSLVQSQLRHLGIKGLDNLACTFLLVFLWDAHFLMTVGGVLT
                     FSYAFLLTVVTVEELSGAKRQLVQVLTISLGILPFLLFYFSSFNPMSMVLTALLSYLF
                     DLFILPLLCLVFCLSPLVTVSICNHLFILLEKVIQFLGNTFNSSLVFGSPTSWHLLIL
                     VISFAIFYDYRQVRQRVITCGLVIALTLLSVKYPLTNEVTFIDIGQGDSILVREWTGK
                     NLLIDVGGRPFFSSKEHWRRGHHVANAQKTLIPYLKSRGIHTIDQLLVTHAEV"
     gene            6574..7230
                     /locus_tag="VHC05_001787"
     CDS             6574..7230
                     /locus_tag="VHC05_001787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CpXC domain-containing protein"
                     /protein_id="HEQ5403040.1"
                     /translation="MMKRKIRMTTIFLTRTSCSNCGKQSTFERFDRVYAAKTPEIISA
                     ILDWDFFKFTCHNCNHKVLIDYPTVVVDEEQKTIIQYCADGNVDVLSMQICSLISEGV
                     NLSEYRIRVVSDIESFVEKVQIVSVGYDDRAIELMKYMNSPLEDGDIQFNYEHMVFTK
                     VGHENYQFMFINNQIAVASLDFSQEQYEYYLADVEDLETNTYYIDSRWAESFFRTSLA
                     "
     gene            7359..8471
                     /locus_tag="VHC05_001788"
     CDS             7359..8471
                     /locus_tag="VHC05_001788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEQ5403041.1"
                     /translation="MVRRNSKITRQQKKIRDAFVSERTVEIIPAKREFTDVKTKKLRV
                     AAYCRVSTFDESQSGSFELQKQTYTERINSNPDWIMAGIYADQGASGTSIKRREQFQQ
                     MLHDCRCGKIDLIIVKSVSRFARNQLDFISIYRELKALSPPVGIYIEDINLNTLDTNS
                     EFILGIMAIVAQGESEQKSASITWSVIERFKRGIPMIPTHNLLGYTKDQYGRVVIDET
                     EAKIVRLIYDSYIEGMTASEIASTLMTNHIPTVTGLERWTSLAVYNILRNEKYKGEII
                     MQKTYTVDCFSHKTRKNNGEKPKYRLKNGIPSIIPESRWDLVQELLKQPRRKSKSTSE
                     IFVPKLYIKKLKSGKLRDFVVLDPSWKSEDIHEVFK"
     gene            8486..8902
                     /locus_tag="VHC05_001789"
     CDS             8486..8902
                     /locus_tag="VHC05_001789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5403042.1"
                     /translation="MRFKDFNLEVVNVERYSSDYSMTVNKNFVTFSKGIVQALEYPAH
                     VLVAFNKDTKVMGIQVCRAKTRGAFSFSKPVGEQKGIVQVGHKTLKETLLTIMSEWKS
                     DKRYRVEGIHIPEDKAFVFELKDFDELSDFRKNDNR"
     gene            9012..9223
                     /locus_tag="VHC05_001790"
                     /pseudo
     CDS             9012..9223
                     /locus_tag="VHC05_001790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368983.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1643 domain-containing protein"
     gene            9732..10949
                     /gene="mef(A)"
                     /locus_tag="VHC05_001791"
     CDS             9732..10949
                     /gene="mef(A)"
                     /locus_tag="VHC05_001791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012102963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide efflux MFS transporter Mef(A)"
                     /protein_id="HEQ5403043.1"
                     /translation="MEKYNNWKLKFYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAM
                     VLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYMELPV
                     WMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAAL
                     LYSVWELNAIIAIDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQN
                     KGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLG
                     LFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQTAL
                     FQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIV
                     CPMINEIRKLDLK"
     gene            11069..12532
                     /gene="msr(D)"
                     /locus_tag="VHC05_001792"
     CDS             11069..12532
                     /gene="msr(D)"
                     /locus_tag="VHC05_001792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000420317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F type ribosomal protection protein Msr(D)"
                     /protein_id="HEQ5403044.1"
                     /translation="MELILKAKDISVEFKGHDVLDINELEVYDYDRIGLVGANGAGKS
                     TLFKVLLGELIPPGCKMNHLGELAYIPQLDEVTLQEEKDFALVGKLGVEQLNIQTMSG
                     GEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
                     EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKRQAAEYEQFIAERARLERAAEEKRK
                     QARKIEQKAKGSSKKKSTEGGGRLAHQKSIGSKEKKMHNAAKSLENRIAALGKVEAPE
                     GIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIPLGAKVALTGGNGTG
                     KTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVL
                     ASMGFKQNDIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEIL
                     MKEYTGTIVFITHDKRLLENVADVVYEIRDKKIKLKH"
     gene            complement(12650..12949)
                     /locus_tag="VHC05_001793"
     CDS             complement(12650..12949)
                     /locus_tag="VHC05_001793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5403045.1"
                     /translation="MNQLEFQRNHLQMDYYSESYQDFERDFYRYSNMNIPLTFLTDDI
                     LKTMATSRKNYFVLNKEKSRDNRDHFFIFEVRTLEENPLIYHYTYKKTTTYLAEK"
     gene            complement(12936..13303)
                     /locus_tag="VHC05_001794"
                     /pseudo
     CDS             complement(12936..13303)
                     /locus_tag="VHC05_001794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254363.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(13300..14715)
                     /locus_tag="VHC05_001795"
     CDS             complement(13300..14715)
                     /locus_tag="VHC05_001795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="HEQ5403046.1"
                     /translation="MGYIDYSIEPQSDIAFLDMKSFYASVECVDRGLHPLYTSLCVMS
                     RADNSAGLILASSPMFKKVFGKANVGRSYDLPFDINTRKFSYQNAWKQGLEVTPKYKS
                     FIEHWAKRTLIVPPRMDRYIEKNLEIQHIFQDYAAPDDILPYSIDEGFIDLTSSLSYF
                     ISDKSMSRKDKLDNVSAMIQRDIYSKTGIISTVGMSNSNPLLAKLALDNEAKKTATMR
                     ANWSYEDVETKVWAIPKLTDFWGIGSKTEIHLQKLGIHSIKELANFNPDILKKEFGKV
                     GVQLWFHANGVDESNVHEPYKPKSRGLGNSQVLPRDYRTQREIEIVLAEMADQVANRL
                     RSAHKKATVVSIHIGYSRTEMKKSINAQKKIDPANLPKTMVGHVLELFRKKYTSGAVR
                     QIGVSYGGFVDENFTLLSLFDDVEQIEKENRLQTAIDVVREQFGFLAIQKGTVLTEGS
                     RNIERSKLIGGHSAGGLEGLK"
     gene            complement(14838..15065)
                     /locus_tag="VHC05_001796"
     CDS             complement(14838..15065)
                     /locus_tag="VHC05_001796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEQ5403047.1"
                     /translation="MKLKDILELGTYGFNPNCKVEIFCMDNFEERLENEGFDEILIPQ
                     NDDAKIYPYAFLIEDSILIAMTEVDDDINEC"
     gene            complement(15068..15757)
                     /locus_tag="VHC05_001797"
     CDS             complement(15068..15757)
                     /locus_tag="VHC05_001797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEQ5403048.1"
                     /translation="MFSHGRLKQRRLEIKLSQTAIANQLNVHRSAYHNWENGRNTPNQ
                     KNLTALAAILDVPVTYFESEYNIVNNYLQLSPDNQLKAEEYVEELLLSQQTSNVIPLF
                     SVQVLSDIQLSAGLGEGFFDEFETETIYSDEEQYGYDIAAWIEGDSMEPVYKSGEVAL
                     IRSNGFDYDGAVYALSWNDSVYIKKLYRDEDGFRMVSLNKDYPEKFIPYEDEPRIVGL
                     VVGHFMPVEGV"
     gene            complement(15871..16791)
                     /locus_tag="VHC05_001798"
     CDS             complement(15871..16791)
                     /locus_tag="VHC05_001798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016621134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="HEQ5403049.1"
                     /translation="MIDLFAGIGGTRLGFQLTNEVETVFTSEWDKFAQKTYITNFGDT
                     PEGDITQIDENTIPDHDILVAGFPCQAFSQAGKRLGFEDTRGTLFFDVARIIKAKRPK
                     AFLLENVKNLKTHDKGKTYKIIISTLENLGYSTSTVLFKARDFGVPQNRERIYIVGFD
                     KTCVNNFSEFRFPEPFHLETKLGNILQTDVDEKYTISDKLWEGHQRRKAEHKTKGNGF
                     GYSLFNADSPYTNTLSARYYKDGSEILIEQKGKNPRKITPREAARLQGFPEEFIIPVS
                     DTQAYKQFGNSVCVPTIHEIAKQILAVLKK"
BASE COUNT         5093 a         2879 c         3402 g         5546 t
ORIGIN      
        1 ggaggagtat aagatatctg atagccatct tactgccttt gacaaagctt caaaagcagg
       61 ttttattatt gctttaggta ttgtttatgg agatattgga acaagccccc tttatacgat
      121 gcagtctcta gttgaaaatc aaggaggggt taatcaggtt tctgaatcct ttattttagg
      181 atcaatctct ttaattattt ggacactgac cttaatcaca acaatcaagt acgttttgat
      241 tgctctaaaa gcggataacc accatgaagg tgggattttt tctttattca ccttggtacg
      301 taaaatgtca ccgtggctca ttattccggc gatgattgga ggtgcaacac ttttgtctga
      361 tggggcttct tacacctgcg gtaacagtta cttcagctat tgagggcttg aaagccgttc
      421 ctggtctgag tcacatctac caaaatcaaa ccaatatcat tatcacaact ctagtgattt
      481 taatagtctt gtttggtatt cagcggtttg gaacaggttt tattggtaaa atttttggac
      541 cagttatgtt tatctggttt agttttctag gtgttagtgg tttttttaat acgttggggc
      601 atctggaaat tttcaaggct atcaatcctt actatgctct gcatttgctg tttagtcctg
      661 aaaaccatcg tgggattttt atcttggggt ccatttttct tgcgacaaca ggagctgaag
      721 ccctttattc ggatttagga catgttggtc gaggaaatat ttatgtgagc tggccctttg
      781 ttaagatgtg tattgtgtgg tcttactgtg gccaggctgc gtggatttta gcgaataaac
      841 actcaggtat tgaactaaac cctttctttg ctagtgtgcc atcacaatta agagtttacc
      901 ttgttagttt ggcaaccttg gcagctatta ttgcctcaca ggctcttatt tcaggctcct
      961 ttaccttggt ttcagaggcc atgcgtttga aaattttccc tttgtttcgt gtgacttacc
     1021 caggggcaaa tttggggcaa ttgtatattc ctgtcattaa ctggatttta tttgcagtga
     1081 cctcttgtac tgttttggct tttagaacat cagcccacat ggaggcagct tatggtcttg
     1141 ctattaccat caccatgttg atgacaacaa tcctcttaaa gtattactta atcaagaaag
     1201 gaacgagacc catcttggct catttagcga tggctttctt tgcccttgta gaattcattt
     1261 tcttcttggc ttcagctatc aaatttatgc acggtggcta tgcggttgtt atcttggcac
     1321 ttgcaattgt ctttgtcatg tttatctggc atgcgggcac acggattgtt ttcaagtatg
     1381 tgaaatctct taatttgaat gattacaagg agcagattaa acaacttcgt gacgacgttt
     1441 gttttgacct ctaccaaaca aatgttgtct acctatccaa tcgtatgcag gatcatatga
     1501 ttgaccggtc tattttatac tccattttag acaagcggcc aaaacgcgct caagtttatt
     1561 ggtttgtaaa tgtccaggta actgatgaac cttatacagc taagtacaag gtagatatga
     1621 tgggaacgga ttatatggtt cgagtcaacc tttatcttgg ttttagaatg ccacagactg
     1681 tgccacgcta tttgcgcacg attgttcagg atttgatgga aagtggccgt ttacccaaac
     1741 aagaacagga atataccatc acacctggtc gtgatgttgg tgattttcgc tttgttttaa
     1801 tagaagaacg ggtctccaat gcacgtcaat tgagtaactt tgaacgcttt atcatgcaga
     1861 ctaaggcaag cattaaacat gttaccgcta gtccaatgcg ttggtttggg cttcaatatt
     1921 cagaagtaac ccttgaagtg gttcccttga ttctatcaga tgtcttgaag ttaccaatca
     1981 aagaattggt gcctgtggaa gacagtgaag cataaaaaaa tcattgagat gataagtctc
     2041 aatgattttt cttttctttt tgatgagtag caatataggc caatttctgg cttcttgttt
     2101 ttcgtttttt aaagagtgct tcagcgctca tcgcagcctc tttgctatca aacacttcgt
     2161 aataaagtaa agaaacaggt aaccggtagc gagtatattt agcccccttt cctgcgttat
     2221 gtgtagctaa acgctttttc aaatcagttg tataaccagt gtagagggtt ttatcaacac
     2281 attctaacac atacatataa gcttttttag tggtcatgat taggttttcc tttggaagca
     2341 gcaccaaaat aaatctcaaa aatatgatca gtgtattctc cgttttcctt gtggacaact
     2401 aaaggaggta aaatagtcat cccttcaata gaaccgtctt tgattgcttc aataagtaac
     2461 atattagctg atttacctaa tttaggatag acaaattgta cccttttagg ggcaagacca
     2521 ttagctctaa ggctatctat aatttccaag aatcgatctg gtcgatgaac cattgccaga
     2581 cgaccatttg atttaagggc atgacgggct acctgacaaa tttcttctaa attagtggtc
     2641 acttcatgac gagccagtaa ataatgttca gagacgttct tcttagaact ttcgtgactt
     2701 ttaaagtaag ggggattgca gagcatcaaa tcaactcctg aacgtggcac atggtttagg
     2761 aggtttttta aatcatcaca aatcatggtt acttggtctt ccagttgatt gagctggata
     2821 gagcgttgtc ccatatcagc aagccgttct tgtaattcga cctcaacgat ggctgccttg
     2881 gttctagtgc tagcaaataa gccaaccgcc ccatttcctg agcacaaatc cacaattaac
     2941 cctttggaag gcatcttggg gaagcgggat aagaggacgc tatcaataga gtaactaaag
     3001 acatccttgt tttgaataat gccaacatca cttgaaaaga gttgatcaat acgttcgcct
     3061 tcttttaaga ttgcttttat catacctgtt attttaacat aaaataggct tgaggtgaat
     3121 gtttgaagag tgattttgac tttcgaaaag tcagctttca tgatacaata agtaagatta
     3181 ttctattaaa ggagaagcct gtgttttacg cttacttacg cggtttagta gtctttttat
     3241 tatgggttgt caatggcaat gcccactacc atcatgaaga aaagatgtta gatgcttctg
     3301 agaattatat tctggtagca ccccatcgaa ccttttggga tccagtttac atggcatttg
     3361 cagcacgtcc taagcagttt atttttatgg ctaaaaaaga gttgtttgca aatcgtctct
     3421 ttgcttggtg gattaaaatg tgtggtgctt ttcctattga tcgtgacaaa ccgagtccag
     3481 atgctattcg ttaccctgtt aatatgctca aaaagagcaa tcgttctctt cttatgtttc
     3541 caagtggaag taggcattcg caagaggtca aaggaggggt cgctgtgatt gctaaattgg
     3601 ctaaggtcaa gattatgcca gcagcctatc aggggcctat gtcggtcaag agattactag
     3661 cgggagaacg ggttgacatg acttttggga atcccattga cgtctcagat attaaacgca
     3721 tgaatgatga agggattgct gaggtggcaa accgtattca ggcagagttt gatcggatgg
     3781 atgacgagtt ggcacctttc caaccaggca aagcaaggaa ccctttaact tatctctacc
     3841 gtttaccatt aggattggtt ttggtggtgg tattattatt aaccatgtta ttttcctata
     3901 ttgctagttt tgtttggaat ccagataaac atcgccatta agaacatgag ggctaacatg
     3961 tgcctgaaat aagaagtgat tgagattagt cttctattga aagaagccgc taatgcttaa
     4021 tcactttttt catttctaaa aaagatattc gatgataccc ttaactcttt taagcacaaa
     4081 aaatgacaat actactatac ttttggatat catttacgaa taaaaagatg aggtaaaaaa
     4141 atgttagacg aattattaat taaaggaaaa tcgtttttga gagagcggta ttttctgcca
     4201 tacctaatta gtcttttatt aggacttttt ctaatactaa gcttcagttt tttgttctgg
     4261 ggaaataggc agagcaaggc agccgttcct gctttgagag aaatatcgcc tgtgaaacag
     4321 caggttagtg aagaaaaaaa ggaaattcaa gaagataaca gtattttagt ggatttaaaa
     4381 ggcgccgtac aaaaagaggg agtttataag ctaactgcta gcagtcgtgt gcgagatgtc
     4441 attgaactag ctggaggcct aacttcagaa gctgataaac atgctattaa ttttgcagaa
     4501 aaactaactg atgagcaagt tgtttatgta cctaaacaag gagaagagat ttctgtgcta
     4561 ccaagatcat tagtttctgg taaaaaagaa actgccagca aggatcagtc aaaggttcat
     4621 attaataagg ccagcttaga agaactacaa catatcccag gtattggtgc taaaagagct
     4681 caggatatta ttgatatgag agataagtta ggtggtttta aagcgttaga agatctccgt
     4741 caggtttcgg ggattggcga aaaaacgctc gagaaattaa aagatgacat tttcttggac
     4801 taagctagtg cccctgtcaa agattcaatt tgctttttta atcttggttc tcttttatca
     4861 aatccatagc cctagctggt taacgtttct ccttagcctt agtttgattt gcttacttgt
     4921 caagcgtttg tctaaaaaag aatttctcgg tgtctttgcc atccttagtt tctgtgcttt
     4981 gtttttgctg tatcagaaac agcagttggt tcaaaaactg gaaattcagc cagtacaaat
     5041 aacctctgta gcattagttc ctgatagtat tcggattaat ggtgatcaat tagctgttct
     5101 tggacgtcat gggaaacatt cttatcagtt attttaccgt ttgaaaagcc aagcagaagc
     5161 ccaattgttc aagaaagagc accgttggtt agtgatgcac gcaaaagtga cattggaaaa
     5221 agctgaggaa gttcgaaatt ttaaaggctt taattatcag acttttttgg cttatcaagg
     5281 aatttacagg atagggaagg tagagcaaat agaacagctt gaagtgattt cacccgagtc
     5341 aatatgtgac tatttgtcct ctttaagacg acgagccatt gttcattgcc agcagcattt
     5401 tccaagacct atgtctcact acctgacggg cctccttttt ggttatttag atacgtcgtt
     5461 tggtgagatg acagattatt atagtcagtt gggtatcatt catctctttg ctttatcagg
     5521 gatgcaggtt ggcttctttc ttacttgttt tagaagggtg ttgctattac tcgcagttcc
     5581 tttggaatgg ataaaatgga tagagcttcc ttttgcttgc ttttatgccg cgttgacagg
     5641 ttatagtatt tctgttattc gaagcctcgt gcagtcgcag ttgcgtcatt taggaataaa
     5701 aggattagac aatctcgctt gtactttttt acttgtcttt ttatgggatg cccatttctt
     5761 aatgactgtt ggtggcgtat taacgtttag ctatgctttt ttgttaacag tggttactgt
     5821 tgaagaatta tcaggagcta aaagacagtt ggtacaagtc ttgaccattt ccctaggaat
     5881 attaccattt ttgctctttt atttttccag ttttaaccca atgtcaatgg tcttaacagc
     5941 tctcttgtct tatctctttg acctttttat tttacctctt ctttgtctgg ttttttgtct
     6001 atcccctttg gtgactgtct caatatgcaa ccatcttttt attttattag aaaaagtcat
     6061 tcaatttctc ggaaatactt tcaatagttc ccttgttttt ggaagcccga ccagttggca
     6121 cttgcttatc ttggtgatta gcttcgctat tttttatgat tatcggcagg tgcgacaacg
     6181 agttatcact tgcggtttgg ttatagcgtt gacgcttttg tctgtcaaat atcctttgac
     6241 caatgaagtg acctttatcg acattggcca gggagatagt attttggtga gggagtggac
     6301 agggaaaaat ctcttaatag atgtaggtgg gcgccctttc ttttcttcaa aagagcactg
     6361 gcgacgagga catcacgtag ctaatgctca gaaaacctta attccttact taaaaagtag
     6421 aggtattcac acaattgacc aactattagt aactcacgca gaagtgtgag ttctaaaatt
     6481 gatacaatac aatttaactt ttttttgaaa aaaattctaa aatttatttt gcattgcgaa
     6541 tataataagt gagagcaagt tgcttactta ataatgatga agaggaaaat tagaatgaca
     6601 acaatttttt taacaagaac aagctgcagc aattgtggaa aacaaagtac atttgaaaga
     6661 tttgataggg tttatgcggc gaagactcct gagattattt ctgctatttt agactgggat
     6721 ttctttaagt ttacttgcca taactgtaac cacaaggtgc taattgatta cccaacagtc
     6781 gtagtagatg aagaacaaaa aacaattatt cagtattgtg cagatggtaa tgttgatgta
     6841 ctttcaatgc aaatatgctc tttgatttca gagggtgtca atctcagtga gtatagaatt
     6901 cgagtagttt cggatataga gtctttcgtt gagaaggtac agattgtttc agtagggtat
     6961 gatgatagag caattgagct tatgaagtat atgaatagtc ctcttgagga tggtgatatt
     7021 cagtttaact atgaacatat ggttttcacc aaggttggac atgaaaacta tcaatttatg
     7081 tttattaata accagattgc agtagcatct ctcgactttt ctcaagaaca atatgagtac
     7141 taccttgctg atgttgaaga cctagaaact aacacatatt acatagactc tagatgggcg
     7201 gaatcattct ttcgtaccag tttggcataa aattcaaaat ctatttataa gtataaatgg
     7261 cctgattttt ggttaggtca ttttttatct tctaatttag aaaaacgtag ttaatatata
     7321 taattattat gtagatttct agaaaggagg taaaaccaat ggtaagacgg aattctaaaa
     7381 ttacccgtca acagaagaaa attcgagatg catttgtatc tgagagaact gttgaaatta
     7441 ttcctgcaaa gcgagagttc actgatgtta aaactaagaa gttacgtgtt gctgcatatt
     7501 gtcgagtaag tacttttgac gaatctcagt caggtagttt tgaacttcaa aaacaaacct
     7561 atactgaaag aatcaatagt aatcctgatt ggataatggc tggaatctat gctgaccaag
     7621 gtgcatcagg aacatcaatc aaacgacgtg aacaattcca acagatgctt catgattgta
     7681 gatgtgggaa gattgacttg ataatcgtta agagtgttag caggtttgct cgtaatcagc
     7741 tagatttcat tagtatttac cgagagttga aggcactatc ccctccagtt ggaatatata
     7801 tcgaagatat aaatttgaat acacttgata cgaatagtga attcattctt ggtattatgg
     7861 ccatagtagc tcaaggtgag agtgaacaaa aaagtgcgtc aattacatgg tctgtcattg
     7921 aacgctttaa aagagggata ccaatgattc ctacccataa ccttcttggg tatacgaaag
     7981 accagtatgg tcgagtagtg atagatgaga cagaagcaaa aattgttcgc ctaatatatg
     8041 attcgtacat cgaaggtatg actgcaagtg agattgcctc tactttaatg accaatcata
     8101 taccaacagt tactggtttg gagcgttgga caagtttagc tgtttataat attctcagaa
     8161 acgagaaata taaaggcgaa atcatcatgc agaagacata tactgttgat tgttttagtc
     8221 ataaaacacg gaaaaataat ggtgaaaagc caaaatatcg attaaaaaat ggaattccct
     8281 ctatcatacc agaatcaaga tgggatttag tacaagaatt actcaagcaa cctagaagaa
     8341 aatcgaaatc tacttctgag atatttgtac ctaaactcta catcaagaaa ctcaaatctg
     8401 gtaagttgag ggattttgtt gtacttgatc ctagttggaa atcggaagac attcacgaag
     8461 tttttaaata agaaagaggt aaattatgcg ttttaaagat tttaatcttg aagttgttaa
     8521 tgttgaacgt tactcatcag attatagcat gacggtgaac aagaactttg ttacatttag
     8581 taaaggaatt gtccaagctt tagaataccc agcacatgta ctggttgcct ttaataagga
     8641 tacaaaggta atgggtatac aagtttgtcg tgcaaaaact aggggagcat tttctttttc
     8701 aaaacctgtt ggggagcaaa aaggtattgt tcaggtaggt cataaaactt taaaagaaac
     8761 actcttaaca atcatgagtg aatggaaatc tgataagcgt tatagagtag aggggattca
     8821 cattcctgaa gataaagctt ttgtttttga attgaaggac tttgatgaac tatctgattt
     8881 tcgtaaaaac gacaatagat agtaaggaac gaagataaaa attattggta ggagtacaac
     8941 tattgtattc ctgccatttt catatccttg caagggggtt catgttaaaa tatactgtag
     9001 gaggtaactc tatgaacgat aaagttacaa aagtcagact agcctatcct ttgggagaag
     9061 acctaatcta tgtattcctg aaaaatataa tgcctaccgt agattcctac tgggatgctt
     9121 aggaacgaat ccactcgtgg ctatatgtat gaatccctca gcagctaatg aggactatag
     9181 cgatcgtaca atcaaccgaa ttctaaatgc tagtaaaaaa attatatgaa gataagctca
     9241 ccgttgaatt caagtcaggg attgagattg acgaagagat atagaatatt aaccgcaatt
     9301 taagggctaa ccccctttgg cggtttttaa tggatttttt taatttataa gttgcttaaa
     9361 atgacttatt atgttaaaat atatgataat ccaaataaga atttaggagg aaccgaaact
     9421 atgacagcct caatgcgttt aagataagct ggcaataaga aaagcagaat ctatacccga
     9481 tgataggctt ttttgttgtg cttatttata cgatattgag cattcattag ttacggtgag
     9541 gatattggtt atttaactat acctttattt aactatacct ttatttaact atgtctttaa
     9601 tatgaatgtt tccaaattgt atgtatgcag accaaaagcc acattgtgga tttaggcctg
     9661 cattttttta ttgcctataa tgctattcaa aatagaaatt taagcaaaat aatatgcagg
     9721 agataatata aatggaaaaa tacaacaatt ggaaacttaa gttttataca atatgggcag
     9781 ggcaagcagt atcattaatc actagtgcca tcttgcaaat ggcgattatt ttttacctta
     9841 cagaaaaaac tggatccgcg atggtcttgt ctatggcttc actattaggt tttttaccct
     9901 atgcggtctt tggacctgca attggtgtgc tagtggatcg tcatgatagg aagaagataa
     9961 tgattggtgc tgatttaatt atcgcagcag ctggttcggt gcttactatt gttgcattct
    10021 atatggagct acctgtctgg atggttatga tagtattgtt tatccgtagc attggaacag
    10081 cttttcacac cccggctctc aatgcggtta cgccactttt agtaccagaa gaacagctta
    10141 cgaaatgtgc aggctatagt cagtctttgc agtctataag ctatattgtt agtccggcgg
    10201 ttgcagcact cttatactcc gtttgggaac taaatgctat tattgccatc gatgtattgg
    10261 gtgctgtgat tgcatctatt acggtagcaa ttgtacgtat tcctaagctg ggtgatcgcg
    10321 tgcaaagttt ggacccaaat ttcataagag aaatgcaaga aggaatggct gtactacggc
    10381 aaaataaagg attatttgct ttattactcg ttggaacatt atatatgttt gtttatatgc
    10441 caattaatgc actattccct ttaattagca tggattactt taatggaaca cctgtgcata
    10501 tttctattac ggaaatttcc tttgcatctg gaatgttgat agggggtcta ttattagggt
    10561 tatttgggaa ttaccaaaag cgaatcttat taataacggc atccattttt atgatgggga
    10621 taagcttaac catttcagga ttacttcccc aaagtggatt tttcattttt gtagtctgct
    10681 gtgcaataat ggggctttct gttccgtttt acagcggtgt gcaaacagct ctttttcagg
    10741 agaaaattaa gcctgaatat ttaggacgtg tattttcttt aactggaagt atcatgtctc
    10801 ttgctatgcc aattggatta attctttctg cactctttgc tgatagaatc ggtgtaaatc
    10861 attggttttt actatcaggt actttaatta tttgcattgc aatagtttgc ccaatgataa
    10921 atgagattag aaaattagat ttaaaataaa caatattgga gggatattta tgtatcttat
    10981 tttcatgtaa ttcttcctgc taaaatcgca gggtttttcc tgcgtacaag caaatgaaag
    11041 catgcgatta tagacaggag gaaatgttat ggaattaata ttaaaagcaa aagacattag
    11101 tgtggaattc aaaggacacg atgttttaga tataaatgaa ttagaagtat atgattatga
    11161 ccgtattggt ttagtaggag caaatggtgc aggaaaaagc actttattca aggtactttt
    11221 aggagaatta attcccccag gatgtaaaat gaatcatctg ggtgaacttg cctatattcc
    11281 ccagttggac gaagtaactc tgcaggagga aaaagatttt gcgcttgtag gcaagctagg
    11341 tgttgagcaa ttaaatatac agaccatgag cggtggtgaa gaaacaaggc ttaaaatagc
    11401 acaggcctta tcggcacagg ttcatggtat tttagcggat gaacctacga gccatttaga
    11461 ccgtgaagga attgattttc taataggaca gctaaaatat tttacaggtg cactgttagt
    11521 tattagccat gaccgctatt ttcttgatga aatagtagat aaaatatggg aactgaaaga
    11581 tggcaaaatc actgagtatt ggggaaacta ttctgattat cttcgtcaga aagaggaaga
    11641 acgtaagaga caagctgcag aatacgaaca atttattgcg gaacgtgctc gattggaaag
    11701 ggctgcggag gaaaagcgaa aacaggctcg taaaatagaa cagaaggcaa aaggttcttc
    11761 aaagaaaaaa agtactgaag gcggagggcg tttagctcat caaaaatcaa taggaagtaa
    11821 ggaaaaaaag atgcataatg ccgctaaatc cctagagaac aggattgcgg cattaggaaa
    11881 agtagaagct ccggaaggca ttcgcagaat tcgtttcagg caaagtaaag cattggagct
    11941 ccataatcca taccctatag tcggtgcgga aattaataaa gtatttgggg ataaggcact
    12001 gtttgaaaat gcatcttttc aaattccgct aggagcaaaa gtggcattaa cgggtggtaa
    12061 tggaaccgga aaaacaactt taatccaaat gatcttaaac catgaagaag gaatttctat
    12121 ttcacctaag gcaaaaatag gttactttgc acagaatggt tacaagtaca acagtaatca
    12181 gaatgttatg gagtttatgc agaaggattg tgattacaat atatcagaaa ttcgttctgt
    12241 gctagcatct atggggttca aacagaacga tattggaaaa agcttatctg ttttaagcgg
    12301 tggagaaatt ataaaattgt tgcttgctaa aatgctcatg ggtagatata acatcctaat
    12361 aatggatgaa cccagtaact tccttgacat accaagttta gaggctttgg aaatactaat
    12421 gaaggagtac accggaacta tcgtgtttat cacccacgat aaacgattac tcgaaaatgt
    12481 agctgatgta gtttatgaaa ttagagataa gaaaattaag ctgaaacatt aaattttagg
    12541 tagtcgctgg tcagtatagt ctgttctggc tggcgactcc attgttaaag agtataaaga
    12601 cttgagattt tatgaagatt aaaaatagga acagtaaatc gaactgctcc tatttttctg
    12661 ctaaatatgt tgtagttttc ttatatgtat aatgatagat tagtggattc tcttctaagg
    12721 ttcttacttc aaatatgaag aagtgatcgc ggttatctct ggacttttcc ttattgagga
    12781 caaagtaatt cttacgtgaa gtcgccattg ttttgaggat atcatcggtc aggaaggtca
    12841 atggaatatt catgttggag tagcggtaga agtcacgttc aaaatcttgg tagctctcgc
    12901 tgtaatagtc catttgcagg tgattacgct gaaattcaag ctgattcata gagcacctcc
    12961 tctacaagtt caatactaac aatgtctttc aatttcaaat taatgtgacc tgttgtagtt
    13021 tttatcaaaa tgaaatcttt ggtcagactt ggtattgttc cagtatagga aacttgattg
    13081 tttttttaac aacatgaatg cgcgtgttca gttgcccagc atacacctga ctgaggagta
    13141 ataatttctt ctccagtgac aaatctgaca tatacgttac tttgtttgca tcgtcagtga
    13201 gtgctgatgt atgctcagat aggaaaaagc ccatccattt ttgcatctta gtatcctggt
    13261 actctcttgc tgactgaaat ggcaagtatg aacgatcaat cattttaatc cctccaatcc
    13321 accagcggaa tgaccgccga taagtttact acgttcaata tttctggaac cttcggttag
    13381 gacggttcct ttttgaatag ctaaaaagcc aaactgttct ctgacaacat caattgctgt
    13441 ctgaagtcta ttttcttttt caatttgttc tacatcatca aaaagtgaca gtagagtaaa
    13501 gttttcatct acaaagccac cataagacac accgatttgc ctcactgcac cagaggtgta
    13561 tttctttcgg aataattcaa gtacatgacc aaccattgtt tttggaagat ttgctgggtc
    13621 aatttttttc tgagcattaa ttgatttttt catctcagtt ctagaatagc caatatgaat
    13681 agaaacgaca gtagcttttt tatgtgccga gcgaagacgg ttagcaacct ggtcagccat
    13741 ttcagctaat acgatttcaa tttctctttg ggttctgtaa tctctaggaa gtacttgtga
    13801 gttacccaat cctcgtgatt ttggtttata gggttcatgg acgttgctct catcaacacc
    13861 gtttgcgtga aaccatagct gaacaccaac tttgccgaat tcttttttga gaatatcagg
    13921 attgaagttg gctagttctt tgattgaatg aataccaagt ttttgtaaat gaatctcggt
    13981 tttactacca atcccccaaa agtctgttag ttttggaatg gcccatacct tggtttctac
    14041 atcttcgtat gaccagttcg ctctcattgt agcagttttt ttagcttcat tatctagagc
    14101 tagtttagct agaagaggat tggaattact cattccaaca gttgagataa tacctgtttt
    14161 actgtaaata tctctctgaa tcatagccga aacattatct aacttatctt tccttgacat
    14221 tgacttatca gaaataaagt aagaaagtga gctagtaagg tcaataaagc cttcatcgat
    14281 tgaatagggg agaatgtcat ctggagcagc atagtcttga aatatatgct gaatctctag
    14341 attcttctca atatatctgt ccattcgcgg aggaacgatg agtgtacgct ttgcccagtg
    14401 ttcgatgaaa gatttatact tcggtgttac ctcaagacct tgtttccacg cattctgata
    14461 gctgaatttt cgagtgttta tatcaaatgg caagtcgtag gaacgaccta catttgcttt
    14521 accgaatact tttttaaaca ttggagaaga agcgagaatc aatcctgccg agttgtctgc
    14581 acggctcatg acgcacagtg atgtgtagag tggatgtaaa cctctatcca cacattctac
    14641 agaagcgtag aaggacttca tatcgaggaa ggctatgtca ctttgaggtt caatagaata
    14701 gtcgatatag cccataggat tatctccttt ttagtttctc tagctcttcg ataagttctc
    14761 cgatgtagtc agtgatgtcg tattcaaatt tgtcaggggt gaagataata cgttcgtctt
    14821 tgatgtaaat catttcttta acattcattg atatcgtcat ccacctcggt catagcaatc
    14881 aaaatagaat cctctatcaa aaaagcgtaa ggatagattt ttgcatcatc attttgagga
    14941 ataagaattt catcgaatcc ttcattctct agccgctctt caaagttgtc catacagaat
    15001 atttcaactt tacagttcgg attgaaacca tacgtcccaa gttctaaaat atcctttagc
    15061 ttcatgacta tactccctcg acaggcataa agtgacctac aactagacca acaattctag
    15121 gttcatcctc gtaagggatg aacttctctg gatagtcctt attcaaggat accattctaa
    15181 atccatcctc atcacggtag agttttttga tatagactga gtcattccat gataatgcat
    15241 agactgcacc atcatagtcg aaaccgtttg aacgaattag tgcgacttct ccactcttat
    15301 atacaggctc catagaatct ccctcaatcc aagcagcaat gtcgtaaccg tattgttcct
    15361 catcagagta gattgtttca gtttcaaact cgtcaaagaa tccttctcca agaccagctg
    15421 agagttggat atctgatagc acttggactg agaagagagg aatgacgttt gaagtttgtt
    15481 gggaaagaag aagttcctca acatactcct ctgcctttag ctggttatcg ggagataact
    15541 gaagatagtt atttacgata ttgtattcag attcaaaata agtgactggt acatcaagaa
    15601 tagcagcgag agcggtgagg tttttttgat taggtgtgtt tcttccgttt tcccaattat
    15661 ggtaagcgga acgatgaaca tttaattgat tagcgattgc agtctgtgat aactttattt
    15721 caagtcttcg ttgttttaat cttccgtgag aaaacatgtt cccctccttt ttgtctagtt
    15781 ataactcaac aaaattatat cagaatattt atattttgca actagaatta aaaaagtcta
    15841 tcaattcaat tgatagactt tatatattaa ctattttttt aggacggcta gtatttgttt
    15901 agcaatttca tgaattgttg gtacacagac agaatttcca aattgtttgt aggcttgtgt
    15961 atcagaaacc ggaattataa actcttcagg gaaaccttgg agtctagcag cttctcgtgg
    16021 agtaatttta cgtgggtttt tacctttttg ttctattaat atttcacttc catctttgta
    16081 gtatcgagca gaaagtgtat ttgtatatgg actatcagca ttaaatagtg agtagccgaa
    16141 tccatttcct tttgttttat gttcagcttt ccttctttgg tgtccttccc agagtttatc
    16201 ggagatagta tacttttcat caacatcagt ttgtagaata tttcctagtt tagtttctaa
    16261 atgaaacggt tcagggaaac ggaattcact aaaattattt acacaagtct tatcaaatcc
    16321 aactatataa atcctttctc tattttgtgg tacaccaaaa tctctggcct taaaaagtac
    16381 agttgatgta ctatatccta aattctcaag agttgaaatg attatcttgt atgtcttacc
    16441 tttatcatgt gtctttaggt ttttgacatt ttcaagtaaa aaagcttttg gacgtttagc
    16501 ttttattatt ctagcaacgt caaaaaataa agttccacga gtatcttcaa atcctagacg
    16561 tttacctgct tgggagaaag cttgacaagg aaaaccagca acgagtatat catgatctgg
    16621 tatagtattt tcatcaatct gagtgatgtc accttctgga gtgtctccaa aattagtaat
    16681 gtatgttttt tgagcaaatt tatcccattc acttgtaaat acagtttcta cttcatttgt
    16741 taattggaaa cctaatctag ttccacctat tccagcaaaa agatcgatca ttttgaacgg
    16801 aagattttca ctaataataa aaggcggatt ctttagagaa ttaaaaaaag actgaatact
    16861 ggactgttca agttttgaag gatgcgtttc ttctgcttcc caacgtctaa tggttctatc
//
